-- dump date 20120504_162855 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 370569000001 SEQ_END SEQ_END NC_008024.1 1937111 1937111 DR NC_008024.1; contig end 1937111..1937111 Streptococcus pyogenes MGAS10750 YP_601495.1 CDS dnaA NC_008024.1 202 1557 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 202..1557 Streptococcus pyogenes MGAS10750 4068215 YP_601496.1 CDS dnaN NC_008024.1 1712 2848 D binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 1712..2848 Streptococcus pyogenes MGAS10750 4068216 YP_601497.1 CDS MGAS10750_Spy0003 NC_008024.1 2923 3120 D hypothetical protein 2923..3120 Streptococcus pyogenes MGAS10750 4068217 YP_601498.1 CDS ychF NC_008024.1 3450 4565 D translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 3450..4565 Streptococcus pyogenes MGAS10750 4068218 YP_601499.1 CDS pth NC_008024.1 4590 5204 D Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 4590..5204 Streptococcus pyogenes MGAS10750 4068219 YP_601500.1 CDS trcF NC_008024.1 5207 8710 D transcription-repair coupling factor 5207..8710 Streptococcus pyogenes MGAS10750 4068220 YP_601501.1 CDS MGAS10750_Spy0007 NC_008024.1 8848 9144 D Heat shock protein 15 8848..9144 Streptococcus pyogenes MGAS10750 4068221 YP_601502.1 CDS divIC NC_008024.1 9131 9502 D cell division protein DivIC 9131..9502 Streptococcus pyogenes MGAS10750 4068222 YP_601503.1 CDS MGAS10750_Spy0009 NC_008024.1 9499 9624 D hypothetical protein 9499..9624 Streptococcus pyogenes MGAS10750 4068223 YP_601504.1 CDS MGAS10750_Spy0010 NC_008024.1 9637 10923 D beta-lactamase 9637..10923 Streptococcus pyogenes MGAS10750 4068224 YP_601505.1 CDS tilS NC_008024.1 10920 12206 D tRNA(Ile)-lysidine synthetase TilS 10920..12206 Streptococcus pyogenes MGAS10750 4068225 YP_601506.1 CDS MGAS10750_Spy0012 NC_008024.1 12211 12753 D Hypoxanthine-guanine phosphoribosyltransferase 12211..12753 Streptococcus pyogenes MGAS10750 4068226 YP_601507.1 CDS ftsH NC_008024.1 12775 14754 D cell division protein ftsH 12775..14754 Streptococcus pyogenes MGAS10750 4068227 YP_601508.1 CDS MGAS10750_Spy0014 NC_008024.1 15012 16472 D amino acid permease 15012..16472 Streptococcus pyogenes MGAS10750 4068228 YP_601509.1 CDS MGAS10750_Spy0015 NC_008024.1 16812 16946 R hypothetical protein complement(16812..16946) Streptococcus pyogenes MGAS10750 4068229 YP_601510.1 CDS MGAS10750_Spy0016 NC_008024.1 30112 30255 R transposase complement(30112..30255) Streptococcus pyogenes MGAS10750 4067223 YP_601511.1 CDS sibA NC_008024.1 31082 32326 D Secreted protein 31082..32326 Streptococcus pyogenes MGAS10750 4067224 YP_601512.1 CDS prsA2 NC_008024.1 32567 33541 D catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 32567..33541 Streptococcus pyogenes MGAS10750 4067225 YP_601513.1 CDS recO NC_008024.1 33727 34482 D involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 33727..34482 Streptococcus pyogenes MGAS10750 4067226 YP_601514.1 CDS plsX NC_008024.1 34507 35592 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 34507..35592 Streptococcus pyogenes MGAS10750 4067227 YP_601515.1 CDS acpP2 NC_008024.1 35585 35827 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 35585..35827 Streptococcus pyogenes MGAS10750 4067228 YP_601516.1 CDS MGAS10750_Spy0022 NC_008024.1 35948 36682 D catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 35948..36682 Streptococcus pyogenes MGAS10750 4067229 YP_601517.1 CDS MGAS10750_Spy0023 NC_008024.1 36758 40531 D phosphoribosylformylglycinamidine synthase 36758..40531 Streptococcus pyogenes MGAS10750 4067230 YP_601518.1 CDS purF NC_008024.1 40635 42146 D Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 40635..42146 Streptococcus pyogenes MGAS10750 4067231 YP_601519.1 CDS purM NC_008024.1 42174 43196 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 42174..43196 Streptococcus pyogenes MGAS10750 4067232 YP_601520.1 CDS purN NC_008024.1 43364 43918 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 43364..43918 Streptococcus pyogenes MGAS10750 4067233 YP_601521.1 CDS purH NC_008024.1 44102 45649 D involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 44102..45649 Streptococcus pyogenes MGAS10750 4067234 YP_601522.1 CDS MGAS10750_Spy0028 NC_008024.1 45708 46133 R Autolysin complement(45708..46133) Streptococcus pyogenes MGAS10750 4067235 YP_601523.1 CDS MGAS10750_Spy0029 NC_008024.1 46439 46831 R Autolysin complement(46439..46831) Streptococcus pyogenes MGAS10750 4067236 YP_601524.1 CDS purD NC_008024.1 46937 48349 D catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 46937..48349 Streptococcus pyogenes MGAS10750 4067237 YP_601525.1 CDS purE NC_008024.1 48627 49118 D phosphoribosylaminoimidazole carboxylase carboxyltransferase subunit 48627..49118 Streptococcus pyogenes MGAS10750 4067238 YP_601526.1 CDS purK NC_008024.1 49069 50202 D With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 49069..50202 Streptococcus pyogenes MGAS10750 4067336 YP_601527.1 CDS MGAS10750_Spy0033 NC_008024.1 50181 51740 D phage resistance endonuclease 50181..51740 Streptococcus pyogenes MGAS10750 4067337 YP_601528.1 CDS MGAS10750_Spy0034 NC_008024.1 51733 52617 D hypothetical protein 51733..52617 Streptococcus pyogenes MGAS10750 4067338 YP_601529.1 CDS purB NC_008024.1 53126 54418 D Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 53126..54418 Streptococcus pyogenes MGAS10750 4067339 YP_601530.1 CDS MGAS10750_Spy0036 NC_008024.1 54550 55461 D transcriptional regulator 54550..55461 Streptococcus pyogenes MGAS10750 4067340 YP_601531.1 CDS ruvB NC_008024.1 55615 56685 D promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 55615..56685 Streptococcus pyogenes MGAS10750 4067341 YP_601532.1 CDS MGAS10750_Spy0038 NC_008024.1 56823 57260 D protein tyrosine phosphatase 56823..57260 Streptococcus pyogenes MGAS10750 4067342 YP_601533.1 CDS MGAS10750_Spy0039 NC_008024.1 57284 57685 D hypothetical protein 57284..57685 Streptococcus pyogenes MGAS10750 4067343 YP_601534.1 CDS MGAS10750_Spy0040 NC_008024.1 57682 59457 D acyltransferase family 57682..59457 Streptococcus pyogenes MGAS10750 4067344 YP_601535.1 CDS MGAS10750_Spy0041 NC_008024.1 59765 62407 D bifunctional; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 59765..62407 Streptococcus pyogenes MGAS10750 4067345 YP_601536.1 CDS adhA NC_008024.1 62659 63675 D similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 62659..63675 Streptococcus pyogenes MGAS10750 4067346 YP_601537.1 CDS MGAS10750_Spy0043 NC_008024.1 64063 65352 D Na+ driven multidrug efflux pump 64063..65352 Streptococcus pyogenes MGAS10750 4067347 YP_601538.1 CDS rpsJ NC_008024.1 65552 65860 D NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 65552..65860 Streptococcus pyogenes MGAS10750 4067348 YP_601539.1 CDS rplC NC_008024.1 66108 66374 D LSU ribosomal protein L3P 66108..66374 Streptococcus pyogenes MGAS10750 4067349 YP_601540.1 CDS MGAS10750_Spy0046 NC_008024.1 66497 66733 D LSU ribosomal protein L3P 66497..66733 Streptococcus pyogenes MGAS10750 4067350 YP_601541.1 CDS MGAS10750_Spy0047 NC_008024.1 66757 67086 D LSU ribosomal protein L1E (L4P) 66757..67086 Streptococcus pyogenes MGAS10750 4067351 YP_601542.1 CDS rplD NC_008024.1 67083 67379 D LSU ribosomal protein L1E (L4P) 67083..67379 Streptococcus pyogenes MGAS10750 4067352 YP_601543.1 CDS rplW NC_008024.1 67379 67675 D binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 67379..67675 Streptococcus pyogenes MGAS10750 4067353 YP_601544.1 CDS rplB NC_008024.1 67693 68526 D one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 67693..68526 Streptococcus pyogenes MGAS10750 4067354 YP_601545.2 CDS rpsS NC_008024.1 68665 68943 D protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 68665..68943 Streptococcus pyogenes MGAS10750 4067355 YP_601546.1 CDS rplV NC_008024.1 68959 69303 D binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 68959..69303 Streptococcus pyogenes MGAS10750 4068270 YP_601547.1 CDS rpsC NC_008024.1 69316 69969 D forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 69316..69969 Streptococcus pyogenes MGAS10750 4068271 YP_601548.1 CDS rplP NC_008024.1 69973 70386 D located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 69973..70386 Streptococcus pyogenes MGAS10750 4068272 YP_601549.1 CDS rpmC NC_008024.1 70396 70602 D one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 70396..70602 Streptococcus pyogenes MGAS10750 4068273 YP_601550.1 CDS rpsQ NC_008024.1 70628 70888 D primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 70628..70888 Streptococcus pyogenes MGAS10750 4068274 YP_601551.1 CDS rplN NC_008024.1 70913 71281 D binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 70913..71281 Streptococcus pyogenes MGAS10750 4068275 YP_601553.1 CDS rplX NC_008024.1 71360 71665 D assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 71360..71665 Streptococcus pyogenes MGAS10750 4068277 YP_601554.1 CDS rplE NC_008024.1 71689 72231 D part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 71689..72231 Streptococcus pyogenes MGAS10750 4068278 YP_601555.1 CDS rpsN NC_008024.1 72247 72432 D located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif; 30S ribosomal protein S14 72247..72432 Streptococcus pyogenes MGAS10750 4068279 YP_601556.1 CDS rpsH NC_008024.1 72583 72981 D binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 72583..72981 Streptococcus pyogenes MGAS10750 4068280 YP_601557.1 CDS rplF NC_008024.1 73184 73720 D ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 73184..73720 Streptococcus pyogenes MGAS10750 4068281 YP_601558.1 CDS rplR NC_008024.1 73816 74181 D binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 73816..74181 Streptococcus pyogenes MGAS10750 4068282 YP_601559.1 CDS rpsE NC_008024.1 74200 74694 D located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 74200..74694 Streptococcus pyogenes MGAS10750 4068283 YP_601560.1 CDS rpmD NC_008024.1 74709 74891 D L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 74709..74891 Streptococcus pyogenes MGAS10750 4068284 YP_601561.1 CDS rplO NC_008024.1 75107 75547 D late assembly protein; 50S ribosomal protein L15 75107..75547 Streptococcus pyogenes MGAS10750 4068285 YP_601562.2 CDS secY NC_008024.1 75564 76868 D forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 75564..76868 Streptococcus pyogenes MGAS10750 4068286 YP_601563.1 CDS adk NC_008024.1 77018 77656 D essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 77018..77656 Streptococcus pyogenes MGAS10750 4068287 YP_601564.1 CDS infA NC_008024.1 77720 77992 D stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 77720..77992 Streptococcus pyogenes MGAS10750 4068288 YP_601565.1 CDS rpmJ NC_008024.1 78018 78134 D smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 78018..78134 Streptococcus pyogenes MGAS10750 4068448 YP_601566.1 CDS rpsM NC_008024.1 78152 78517 D located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 78152..78517 Streptococcus pyogenes MGAS10750 4068449 YP_601567.1 CDS rpsK NC_008024.1 78535 78918 D located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 78535..78918 Streptococcus pyogenes MGAS10750 4068450 YP_601568.1 CDS rpoA NC_008024.1 78964 79902 D catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 78964..79902 Streptococcus pyogenes MGAS10750 4068451 YP_601569.1 CDS rplQ NC_008024.1 79917 80303 D is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 79917..80303 Streptococcus pyogenes MGAS10750 4068452 YP_601570.1 CDS MGAS10750_Spy0076 NC_008024.1 80809 81801 R transposase complement(80809..81801) Streptococcus pyogenes MGAS10750 4068453 YP_601571.1 CDS MGAS10750_Spy0077 NC_008024.1 81989 82123 R hypothetical protein complement(81989..82123) Streptococcus pyogenes MGAS10750 4068454 YP_601572.1 CDS MGAS10750_Spy0078 NC_008024.1 88544 88744 D transposase 88544..88744 Streptococcus pyogenes MGAS10750 4068447 YP_601573.1 CDS MGAS10750_Spy0079 NC_008024.1 88829 89617 D transposase 88829..89617 Streptococcus pyogenes MGAS10750 4067125 YP_601574.1 CDS MGAS10750_Spy0080 NC_008024.1 89601 89771 D hypothetical protein 89601..89771 Streptococcus pyogenes MGAS10750 4067126 YP_601575.1 CDS MGAS10750_Spy0081 NC_008024.1 89892 90077 D hypothetical protein 89892..90077 Streptococcus pyogenes MGAS10750 4067127 YP_601576.1 CDS MGAS10750_Spy0082 NC_008024.1 90715 91023 D 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 90715..91023 Streptococcus pyogenes MGAS10750 4067128 YP_601577.1 CDS MGAS10750_Spy0083 NC_008024.1 91063 91290 D 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 91063..91290 Streptococcus pyogenes MGAS10750 4067129 YP_601578.1 CDS adcR NC_008024.1 91400 91843 D MarR family transcriptional regulator 91400..91843 Streptococcus pyogenes MGAS10750 4067130 YP_601579.1 CDS adcC NC_008024.1 91847 92566 D High-affinity zinc uptake system ATP-binding protein znuC 91847..92566 Streptococcus pyogenes MGAS10750 4067131 YP_601580.1 CDS adcB NC_008024.1 92520 93374 D High-affinity zinc uptake system membrane protein znuB 92520..93374 Streptococcus pyogenes MGAS10750 4067132 YP_601581.1 CDS MGAS10750_Spy0087 NC_008024.1 93414 93797 R Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) complement(93414..93797) Streptococcus pyogenes MGAS10750 4067133 YP_601582.1 CDS tyrS NC_008024.1 93848 95104 R catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase complement(93848..95104) Streptococcus pyogenes MGAS10750 4067134 YP_601583.1 CDS pbp1b NC_008024.1 95196 97508 D Multimodular transpeptidase-transglycosylase PBP 1B 95196..97508 Streptococcus pyogenes MGAS10750 4067135 YP_601584.1 CDS rpoB NC_008024.1 97772 101338 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 97772..101338 Streptococcus pyogenes MGAS10750 4067136 YP_601585.1 CDS rpoC NC_008024.1 101429 105070 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 101429..105070 Streptococcus pyogenes MGAS10750 4067137 YP_601586.1 CDS MGAS10750_Spy0092 NC_008024.1 105222 105587 D DNA binding protein 105222..105587 Streptococcus pyogenes MGAS10750 4067138 YP_601587.1 CDS comYA NC_008024.1 105680 106618 D ComG operon protein 1 105680..106618 Streptococcus pyogenes MGAS10750 4067139 YP_601588.1 CDS comYB NC_008024.1 106497 107588 D ComG operon protein 2 106497..107588 Streptococcus pyogenes MGAS10750 4067140 YP_601589.1 CDS comYC NC_008024.1 107590 107916 D ComG operon protein 3 107590..107916 Streptococcus pyogenes MGAS10750 4067141 YP_601590.1 CDS MGAS10750_Spy0096 NC_008024.1 107891 108319 D ComG operon protein 4 107891..108319 Streptococcus pyogenes MGAS10750 4067142 YP_601591.1 CDS MGAS10750_Spy0097 NC_008024.1 108276 108560 D ComG operon protein 5 108276..108560 Streptococcus pyogenes MGAS10750 4067143 YP_601592.1 CDS comYD NC_008024.1 108553 108987 D ComG operon protein 6 108553..108987 Streptococcus pyogenes MGAS10750 4067144 YP_601593.1 CDS MGAS10750_Spy0099 NC_008024.1 108971 109297 D ComG operon protein 6 108971..109297 Streptococcus pyogenes MGAS10750 4067239 YP_601594.1 CDS MGAS10750_Spy0100 NC_008024.1 109350 110348 D Adenine-specific methyltransferase 109350..110348 Streptococcus pyogenes MGAS10750 4067240 YP_601595.1 CDS ackA NC_008024.1 110407 111603 D AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 110407..111603 Streptococcus pyogenes MGAS10750 4067241 YP_601596.1 CDS MGAS10750_Spy0102 NC_008024.1 111790 112098 D hypothetical protein 111790..112098 Streptococcus pyogenes MGAS10750 4067242 YP_601597.1 CDS proC NC_008024.1 112181 112951 R catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase complement(112181..112951) Streptococcus pyogenes MGAS10750 4067243 YP_601598.1 CDS pepA NC_008024.1 112999 114066 R glutamyl aminopeptidase complement(112999..114066) Streptococcus pyogenes MGAS10750 4067244 YP_601599.1 CDS MGAS10750_Spy0105 NC_008024.1 114176 114340 R hypothetical protein complement(114176..114340) Streptococcus pyogenes MGAS10750 4067245 YP_601600.1 CDS MGAS10750_Spy0106 NC_008024.1 114522 114815 D hypothetical protein 114522..114815 Streptococcus pyogenes MGAS10750 4067246 YP_601601.1 CDS MGAS10750_Spy0107 NC_008024.1 114812 115129 D Thioredoxin 114812..115129 Streptococcus pyogenes MGAS10750 4067247 YP_601602.1 CDS MGAS10750_Spy0108 NC_008024.1 115147 115773 D tRNA binding domain protein 115147..115773 Streptococcus pyogenes MGAS10750 4067248 YP_601603.1 CDS MGAS10750_Spy0109 NC_008024.1 115925 116320 D binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 115925..116320 Streptococcus pyogenes MGAS10750 4067249 YP_601604.1 CDS MGAS10750_Spy0110 NC_008024.1 116580 117269 R bifunctional; deoxyadenosine kinase / deoxyguanosine kinase complement(116580..117269) Streptococcus pyogenes MGAS10750 4067250 YP_601605.1 CDS MGAS10750_Spy0111 NC_008024.1 117241 118290 R tRNA-dihydrouridine synthase complement(117241..118290) Streptococcus pyogenes MGAS10750 4067251 YP_601606.1 CDS hslO NC_008024.1 118205 119077 R becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin complement(118205..119077) Streptococcus pyogenes MGAS10750 4067252 YP_601607.1 CDS rofA NC_008024.1 119224 120816 R RofA family transcriptional regulator complement(119224..120816) Streptococcus pyogenes MGAS10750 4067253 YP_601608.1 CDS MGAS10750_Spy0114 NC_008024.1 120949 122568 D Fibronectin-binding protein 120949..122568 Streptococcus pyogenes MGAS10750 4067254 YP_601609.1 CDS MGAS10750_Spy0115 NC_008024.1 123778 127881 D Fibronectin-binding protein 123778..127881 Streptococcus pyogenes MGAS10750 4067255 YP_601610.1 CDS MGAS10750_Spy0116 NC_008024.1 128002 130164 D cell wall surface anchor family protein 128002..130164 Streptococcus pyogenes MGAS10750 4067256 YP_601611.1 CDS MGAS10750_Spy0117 NC_008024.1 130177 131022 D cell wall surface anchor family protein 130177..131022 Streptococcus pyogenes MGAS10750 4067257 YP_601612.1 CDS MGAS10750_Spy0118 NC_008024.1 131104 131976 D Sortase 131104..131976 Streptococcus pyogenes MGAS10750 4066578 YP_601613.1 CDS MGAS10750_Spy0119 NC_008024.1 131963 132796 D Sortase 131963..132796 Streptococcus pyogenes MGAS10750 4066579 YP_601614.1 CDS MGAS10750_Spy0120 NC_008024.1 132816 133532 D Sortase 132816..133532 Streptococcus pyogenes MGAS10750 4066580 YP_601615.1 CDS MGAS10750_Spy0121 NC_008024.1 134014 134673 R hypothetical protein complement(134014..134673) Streptococcus pyogenes MGAS10750 4066581 YP_601616.1 CDS atoE NC_008024.1 134993 136432 D Short-chain fatty acids transporter 134993..136432 Streptococcus pyogenes MGAS10750 4066582 YP_601617.1 CDS MGAS10750_Spy0123 NC_008024.1 136500 137411 R LysR family transcriptional regulator complement(136500..137411) Streptococcus pyogenes MGAS10750 4066583 YP_601618.1 CDS MGAS10750_Spy0124 NC_008024.1 137532 138716 D acetyl-CoA acetyltransferase 137532..138716 Streptococcus pyogenes MGAS10750 4066584 YP_601619.1 CDS atoD2 NC_008024.1 138671 139387 D acetate CoA-transferase alpha subunit 138671..139387 Streptococcus pyogenes MGAS10750 4066585 YP_601620.1 CDS MGAS10750_Spy0126 NC_008024.1 139390 140037 D acetate CoA-transferase beta subunit 139390..140037 Streptococcus pyogenes MGAS10750 4066586 YP_601621.1 CDS MGAS10750_Spy0127 NC_008024.1 140159 140839 R DNA-binding protein complement(140159..140839) Streptococcus pyogenes MGAS10750 4066587 YP_601622.1 CDS MGAS10750_Spy0128 NC_008024.1 141013 141378 D translation initiation inhibitor 141013..141378 Streptococcus pyogenes MGAS10750 4066588 YP_601623.1 CDS sloR NC_008024.1 141415 142434 D PfoR family transcriptional regulator 141415..142434 Streptococcus pyogenes MGAS10750 4066589 YP_601624.1 CDS MGAS10750_Spy0130 NC_008024.1 142885 143208 D hypothetical protein 142885..143208 Streptococcus pyogenes MGAS10750 4066590 YP_601625.1 CDS ntpI NC_008024.1 143198 145198 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I is part of the membrane proton channel.; V-type ATP synthase subunit I 143198..145198 Streptococcus pyogenes MGAS10750 4066591 YP_601626.2 CDS ntpK NC_008024.1 145200 145679 D produces ATP from ADP in the presence of a proton gradient across the membrane; the K subunit is a nonenzymatic component which binds the dimeric form by interacting with the G and E subunits; V-type ATP synthase subunit K 145200..145679 Streptococcus pyogenes MGAS10750 4066592 YP_601627.1 CDS ntpE NC_008024.1 145748 146332 D V-type sodium ATP synthase subunit E 145748..146332 Streptococcus pyogenes MGAS10750 4066593 YP_601628.1 CDS ntpC NC_008024.1 146348 147346 D V-type sodium ATP synthase subunit C 146348..147346 Streptococcus pyogenes MGAS10750 4066594 YP_601629.1 CDS ntpF NC_008024.1 147343 147663 D produces ATP from ADP in the presence of a proton gradient across the membrane; the F subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit F 147343..147663 Streptococcus pyogenes MGAS10750 4066595 YP_601630.1 CDS ntpA NC_008024.1 147864 149639 D produces ATP from ADP in the presence of a proton gradient across the membrane; the A subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit A 147864..149639 Streptococcus pyogenes MGAS10750 4066596 YP_601631.1 CDS ntpB NC_008024.1 149640 151055 D produces ATP from ADP in the presence of a proton gradient across the membrane; the B subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit B 149640..151055 Streptococcus pyogenes MGAS10750 4066597 YP_601632.1 CDS ntpD NC_008024.1 151079 151726 D produces ATP from ADP in the presence of a proton gradient across the membrane; the D subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit D 151079..151726 Streptococcus pyogenes MGAS10750 4066866 YP_601633.1 CDS MGAS10750_Spy0139 NC_008024.1 151846 153108 R Tellurite resistance protein complement(151846..153108) Streptococcus pyogenes MGAS10750 4066867 YP_601634.1 CDS MGAS10750_Spy0140 NC_008024.1 153121 153999 R hypothetical protein complement(153121..153999) Streptococcus pyogenes MGAS10750 4066868 YP_601635.1 CDS purA NC_008024.1 154437 155729 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 154437..155729 Streptococcus pyogenes MGAS10750 4066869 YP_601636.1 CDS MGAS10750_Spy0142 NC_008024.1 156056 157099 D nucleoside-binding protein 156056..157099 Streptococcus pyogenes MGAS10750 4066870 YP_601637.1 CDS MGAS10750_Spy0143 NC_008024.1 157125 157238 R hypothetical protein complement(157125..157238) Streptococcus pyogenes MGAS10750 4066871 YP_601638.1 CDS nusG NC_008024.1 157256 157810 D Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 157256..157810 Streptococcus pyogenes MGAS10750 4066872 YP_601639.1 CDS nga NC_008024.1 158172 159536 D NAD glycohydrolase 158172..159536 Streptococcus pyogenes MGAS10750 4066873 YP_601640.1 CDS ifs NC_008024.1 159541 160026 D streptococcal NAD glycohydrolase inhibitor 159541..160026 Streptococcus pyogenes MGAS10750 4066874 YP_601641.1 CDS slo NC_008024.1 160041 161765 D streptolysin O 160041..161765 Streptococcus pyogenes MGAS10750 4066875 YP_601642.1 CDS MGAS10750_Spy0148 NC_008024.1 162020 162373 D hypothetical protein 162020..162373 Streptococcus pyogenes MGAS10750 4066876 YP_601643.1 CDS MGAS10750_Spy0149 NC_008024.1 162657 162887 R hypothetical protein complement(162657..162887) Streptococcus pyogenes MGAS10750 4066877 YP_601644.1 CDS MGAS10750_Spy0150 NC_008024.1 163299 163466 R hypothetical protein complement(163299..163466) Streptococcus pyogenes MGAS10750 4066878 YP_601645.1 CDS MGAS10750_Spy0151 NC_008024.1 163638 163886 R hypothetical protein complement(163638..163886) Streptococcus pyogenes MGAS10750 4066879 YP_601646.1 CDS metB NC_008024.1 164118 165509 D cystathionine beta-lyase 164118..165509 Streptococcus pyogenes MGAS10750 4066880 YP_601647.1 CDS leuS NC_008024.1 165721 168222 D leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 165721..168222 Streptococcus pyogenes MGAS10750 4066881 YP_601648.1 CDS MGAS10750_Spy0154 NC_008024.1 168529 169962 D membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 168529..169962 Streptococcus pyogenes MGAS10750 4066882 YP_601649.1 CDS MGAS10750_Spy0155 NC_008024.1 170033 170311 D PTS system, 3-keto-L-gulonate specific IIB component 170033..170311 Streptococcus pyogenes MGAS10750 4066883 YP_601650.1 CDS MGAS10750_Spy0156 NC_008024.1 170434 170919 D PTS system, 3-keto-L-gulonate specific IIA component 170434..170919 Streptococcus pyogenes MGAS10750 4066884 YP_601651.1 CDS ulaD NC_008024.1 171026 171688 D catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 171026..171688 Streptococcus pyogenes MGAS10750 4066957 YP_601652.1 CDS MGAS10750_Spy0158 NC_008024.1 171651 172556 D L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; L-xylulose 5-phosphate 3-epimerase 171651..172556 Streptococcus pyogenes MGAS10750 4066958 YP_601653.1 CDS araD NC_008024.1 172534 173262 D catalyzes the formation of D-xylulose 5-phosphate from L-ribulose 5-phosphate in the L-arabinose and L-ascorbate degradation pathways; L-ribulose-5-phosphate 4-epimerase 172534..173262 Streptococcus pyogenes MGAS10750 4066959 YP_601654.1 CDS MGAS10750_Spy0160 NC_008024.1 173320 173466 D hypothetical protein 173320..173466 Streptococcus pyogenes MGAS10750 4066960 YP_601655.1 CDS MGAS10750_Spy0161 NC_008024.1 173587 175233 D transcription antiterminator, BglG family 173587..175233 Streptococcus pyogenes MGAS10750 4066961 YP_601656.1 CDS MGAS10750_Spy0162 NC_008024.1 175486 176577 D L-ascorbate 6-phosphate lactonase 175486..176577 Streptococcus pyogenes MGAS10750 4066962 YP_601657.1 CDS opuAA NC_008024.1 177065 178261 D glycine betaine transport ATP-binding protein 177065..178261 Streptococcus pyogenes MGAS10750 4066963 YP_601658.1 CDS opuABC NC_008024.1 178277 180004 D glycine betaine-binding protein / glycine betaine transport system permease 178277..180004 Streptococcus pyogenes MGAS10750 4066964 YP_601659.1 CDS polA NC_008024.1 180135 182777 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 180135..182777 Streptococcus pyogenes MGAS10750 4066965 YP_601660.1 CDS MGAS10750_Spy0166 NC_008024.1 182963 183418 D CoA binding protein 182963..183418 Streptococcus pyogenes MGAS10750 4066966 YP_601661.1 CDS perR NC_008024.1 183470 183937 D Ferric uptake regulation protein 183470..183937 Streptococcus pyogenes MGAS10750 4066967 YP_601662.1 CDS MGAS10750_Spy0168 NC_008024.1 184039 184902 R membrane protein complement(184039..184902) Streptococcus pyogenes MGAS10750 4066968 YP_601663.1 CDS MGAS10750_Spy0169 NC_008024.1 184939 185124 D hypothetical protein 184939..185124 Streptococcus pyogenes MGAS10750 4066969 YP_601664.1 CDS tgt NC_008024.1 185121 186263 D Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 185121..186263 Streptococcus pyogenes MGAS10750 4066970 YP_601665.1 CDS MGAS10750_Spy0171 NC_008024.1 186480 186791 D Zinc finger protein 186480..186791 Streptococcus pyogenes MGAS10750 4066971 YP_601666.1 CDS MGAS10750_Spy0172 NC_008024.1 186795 187334 D BioY protein 186795..187334 Streptococcus pyogenes MGAS10750 4066972 YP_601667.1 CDS MGAS10750_Spy0173 NC_008024.1 187474 188253 D Metal-dependent hydrolase 187474..188253 Streptococcus pyogenes MGAS10750 4066973 YP_601668.1 CDS MGAS10750_Spy0174 NC_008024.1 188229 188768 D tRNA-specific adenosine deaminase 188229..188768 Streptococcus pyogenes MGAS10750 4066974 YP_601669.1 CDS MGAS10750_Spy0175 NC_008024.1 189382 190614 R S-layer protein / Peptidoglycan endo-beta-N-acetylglucosaminidase complement(189382..190614) Streptococcus pyogenes MGAS10750 4066975 YP_601670.1 CDS MGAS10750_Spy0176 NC_008024.1 190656 190763 D hypothetical protein 190656..190763 Streptococcus pyogenes MGAS10750 4066976 YP_601671.1 CDS MGAS10750_Spy0177 NC_008024.1 191215 191532 D hypothetical protein 191215..191532 Streptococcus pyogenes MGAS10750 4068251 YP_601672.1 CDS MGAS10750_Spy0178 NC_008024.1 191810 191929 D hypothetical protein 191810..191929 Streptococcus pyogenes MGAS10750 4068252 YP_601673.1 CDS pgi NC_008024.1 192172 193530 D functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 192172..193530 Streptococcus pyogenes MGAS10750 4068253 YP_601674.1 CDS MGAS10750_Spy0180 NC_008024.1 193879 194799 R transcriptional regulator complement(193879..194799) Streptococcus pyogenes MGAS10750 4068254 YP_601675.1 CDS MGAS10750_Spy0181 NC_008024.1 194811 195386 R transcriptional regulator complement(194811..195386) Streptococcus pyogenes MGAS10750 4068255 YP_601676.1 CDS MGAS10750_Spy0182 NC_008024.1 195932 196132 D transposase 195932..196132 Streptococcus pyogenes MGAS10750 4068256 YP_601677.1 CDS MGAS10750_Spy0183 NC_008024.1 196217 197005 D transposase 196217..197005 Streptococcus pyogenes MGAS10750 4068257 YP_601678.1 CDS MGAS10750_Spy0184 NC_008024.1 196989 197114 D hypothetical protein 196989..197114 Streptococcus pyogenes MGAS10750 4068258 YP_601679.1 CDS MGAS10750_Spy0185 NC_008024.1 197090 197182 D hypothetical protein 197090..197182 Streptococcus pyogenes MGAS10750 4068259 YP_601680.1 CDS MGAS10750_Spy0186 NC_008024.1 197195 197302 D hypothetical protein 197195..197302 Streptococcus pyogenes MGAS10750 4068260 YP_601681.1 CDS MGAS10750_Spy0187 NC_008024.1 197330 198001 D Rhomboid family; membrane protein 197330..198001 Streptococcus pyogenes MGAS10750 4068261 YP_601682.1 CDS hasC NC_008024.1 198101 199006 R UTP--glucose-1-phosphate uridylyltransferase complement(198101..199006) Streptococcus pyogenes MGAS10750 4068262 YP_601683.1 CDS gpsA NC_008024.1 199033 200049 R catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase complement(199033..200049) Streptococcus pyogenes MGAS10750 4068263 YP_601684.1 CDS MGAS10750_Spy0190 NC_008024.1 200347 200796 D MarR family transcriptional regulator 200347..200796 Streptococcus pyogenes MGAS10750 4068264 YP_601685.1 CDS MGAS10750_Spy0191 NC_008024.1 200789 202495 D multidrug resistance ABC transporter ATP-binding and permease 200789..202495 Streptococcus pyogenes MGAS10750 4068265 YP_601686.1 CDS MGAS10750_Spy0192 NC_008024.1 202495 204282 D multidrug/protein/lipid ABC transporter family, ATP-binding and permease 202495..204282 Streptococcus pyogenes MGAS10750 4068266 YP_601687.1 CDS MGAS10750_Spy0193 NC_008024.1 204400 205167 D hypothetical protein 204400..205167 Streptococcus pyogenes MGAS10750 4068267 YP_601688.1 CDS dut NC_008024.1 205277 205723 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 205277..205723 Streptococcus pyogenes MGAS10750 4068268 YP_601689.1 CDS radA NC_008024.1 205804 207165 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 205804..207165 Streptococcus pyogenes MGAS10750 4068269 YP_601690.1 CDS MGAS10750_Spy0196 NC_008024.1 207351 207851 D Carbonic anhydrase 207351..207851 Streptococcus pyogenes MGAS10750 4066538 YP_601691.1 CDS MGAS10750_Spy0197 NC_008024.1 207946 208692 D hypothetical protein 207946..208692 Streptococcus pyogenes MGAS10750 4066539 YP_601692.1 CDS gltX NC_008024.1 208874 210319 D Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 208874..210319 Streptococcus pyogenes MGAS10750 4066540 YP_601693.1 CDS fasB NC_008024.1 210714 211883 D Sensory transduction protein kinase FasB 210714..211883 Streptococcus pyogenes MGAS10750 4066541 YP_601694.1 CDS fasC NC_008024.1 212056 213339 D Sensory transduction protein kinase FasC 212056..213339 Streptococcus pyogenes MGAS10750 4066542 YP_601695.1 CDS fasA NC_008024.1 213343 214083 D Response regulator FasA 213343..214083 Streptococcus pyogenes MGAS10750 4066543 YP_601696.1 CDS rnpA NC_008024.1 214623 214982 D protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 214623..214982 Streptococcus pyogenes MGAS10750 4066544 YP_601697.1 CDS MGAS10750_Spy0203 NC_008024.1 214948 215775 D 60 kDa inner membrane protein YIDC 214948..215775 Streptococcus pyogenes MGAS10750 4066545 YP_601698.1 CDS MGAS10750_Spy0204 NC_008024.1 215787 216701 D Jag protein 215787..216701 Streptococcus pyogenes MGAS10750 4066546 YP_601699.1 CDS rpmH NC_008024.1 217015 217149 D in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 217015..217149 Streptococcus pyogenes MGAS10750 4066547 YP_601700.1 CDS MGAS10750_Spy0206 NC_008024.1 217425 218129 D Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 217425..218129 Streptococcus pyogenes MGAS10750 4066548 YP_601701.1 CDS MGAS10750_Spy0207 NC_008024.1 218178 219497 D N-acetylneuraminate-binding protein 218178..219497 Streptococcus pyogenes MGAS10750 4066549 YP_601702.1 CDS MGAS10750_Spy0208 NC_008024.1 219498 220487 D N-acetylneuraminate transport system permease 219498..220487 Streptococcus pyogenes MGAS10750 4066550 YP_601703.1 CDS MGAS10750_Spy0209 NC_008024.1 220500 221330 D N-acetylneuraminate transport system permease 220500..221330 Streptococcus pyogenes MGAS10750 4066551 YP_601704.1 CDS MGAS10750_Spy0210 NC_008024.1 221350 221805 D hypothetical protein 221350..221805 Streptococcus pyogenes MGAS10750 4066552 YP_601705.1 CDS MGAS10750_Spy0211 NC_008024.1 221849 222511 D hypothetical protein 221849..222511 Streptococcus pyogenes MGAS10750 4066553 YP_601706.1 CDS nanH NC_008024.1 222523 223437 D N-acetylneuraminate lyase 222523..223437 Streptococcus pyogenes MGAS10750 4066554 YP_601707.1 CDS MGAS10750_Spy0213 NC_008024.1 223459 224397 D N-acetylmannosamine kinase / transcriptional regulator 223459..224397 Streptococcus pyogenes MGAS10750 4066555 YP_601708.1 CDS MGAS10750_Spy0214 NC_008024.1 224508 225350 R RpiR family transcriptional regulator complement(224508..225350) Streptococcus pyogenes MGAS10750 4066556 YP_601709.1 CDS tatD NC_008024.1 225527 226414 D DNase, TatD family 225527..226414 Streptococcus pyogenes MGAS10750 4066557 YP_601710.1 CDS MGAS10750_Spy0216 NC_008024.1 226365 226976 D ribonuclease M5 226365..226976 Streptococcus pyogenes MGAS10750 4068196 YP_601711.1 CDS ksgA NC_008024.1 227066 227962 D catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 227066..227962 Streptococcus pyogenes MGAS10750 4068197 YP_601712.1 CDS MGAS10750_Spy0218 NC_008024.1 228388 229260 D EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 228388..229260 Streptococcus pyogenes MGAS10750 4068198 YP_601713.1 CDS rpe NC_008024.1 229270 229932 D catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 229270..229932 Streptococcus pyogenes MGAS10750 4068199 YP_601714.1 CDS MGAS10750_Spy0220 NC_008024.1 229925 230557 D Thiamin pyrophosphokinase 229925..230557 Streptococcus pyogenes MGAS10750 4068200 YP_601715.1 CDS MGAS10750_Spy0221 NC_008024.1 230559 231830 D RmuC family protein 230559..231830 Streptococcus pyogenes MGAS10750 4068201 YP_601716.1 CDS cbf NC_008024.1 231820 232758 D CMP-binding factor 231820..232758 Streptococcus pyogenes MGAS10750 4068202 YP_601717.1 CDS purR NC_008024.1 233025 233864 D pur operon repressor 233025..233864 Streptococcus pyogenes MGAS10750 4068203 YP_601718.1 CDS prgA NC_008024.1 233837 236476 D Surface exclusion protein 233837..236476 Streptococcus pyogenes MGAS10750 4068204 YP_601719.1 CDS rpsL NC_008024.1 236684 237097 D interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 236684..237097 Streptococcus pyogenes MGAS10750 4068205 YP_601720.1 CDS rpsG NC_008024.1 237118 237588 D binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 237118..237588 Streptococcus pyogenes MGAS10750 4068206 YP_601721.1 CDS fus NC_008024.1 238072 240150 D EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 238072..240150 Streptococcus pyogenes MGAS10750 4068207 YP_601722.1 CDS plr NC_008024.1 240464 241501 D glyceraldehyde 3-phosphate dehydrogenase 240464..241501 Streptococcus pyogenes MGAS10750 4068208 YP_601723.1 CDS MGAS10750_Spy0229 NC_008024.1 241727 241843 R hypothetical protein complement(241727..241843) Streptococcus pyogenes MGAS10750 4068209 YP_601724.1 CDS MGAS10750_Spy0230 NC_008024.1 241985 242794 R amino acid transport ATP-binding protein complement(241985..242794) Streptococcus pyogenes MGAS10750 4068210 YP_601725.1 CDS MGAS10750_Spy0231 NC_008024.1 242718 244304 R amino acid ABC transporter permease/substrate-binding protein complement(242718..244304) Streptococcus pyogenes MGAS10750 4068211 YP_601726.1 CDS MGAS10750_Spy0232 NC_008024.1 244484 244801 D hypothetical protein 244484..244801 Streptococcus pyogenes MGAS10750 4068212 YP_601727.1 CDS MGAS10750_Spy0233 NC_008024.1 244888 246066 D hypothetical protein 244888..246066 Streptococcus pyogenes MGAS10750 4068213 YP_601728.1 CDS MGAS10750_Spy0234 NC_008024.1 246082 246408 D hypothetical protein 246082..246408 Streptococcus pyogenes MGAS10750 4068214 YP_601729.1 CDS bacA NC_008024.1 246474 247313 D BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 246474..247313 Streptococcus pyogenes MGAS10750 4068232 YP_601730.1 CDS mecA NC_008024.1 247453 248220 D enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence; adaptor protein 247453..248220 Streptococcus pyogenes MGAS10750 4068233 YP_601731.1 CDS MGAS10750_Spy0237 NC_008024.1 248227 249396 D Undecaprenyl-phosphate alpha-N-acetylglucosaminephosphotransferase 248227..249396 Streptococcus pyogenes MGAS10750 4068234 YP_601732.1 CDS rgpG NC_008024.1 249366 249491 D hypothetical protein 249366..249491 Streptococcus pyogenes MGAS10750 4068235 YP_601733.1 CDS MGAS10750_Spy0239 NC_008024.1 249518 250288 D ATP-dependent transporter sufC 249518..250288 Streptococcus pyogenes MGAS10750 4068236 YP_601734.1 CDS MGAS10750_Spy0240 NC_008024.1 250383 251645 D SufD protein 250383..251645 Streptococcus pyogenes MGAS10750 4068237 YP_601735.1 CDS nifS3 NC_008024.1 251676 252902 D bifunctional; cysteine desulfurase / Selenocysteine lyase 251676..252902 Streptococcus pyogenes MGAS10750 4068238 YP_601736.1 CDS nifU NC_008024.1 252889 253368 D IscU protein 252889..253368 Streptococcus pyogenes MGAS10750 4068239 YP_601737.1 CDS MGAS10750_Spy0243 NC_008024.1 253361 254779 D ABC transporter 253361..254779 Streptococcus pyogenes MGAS10750 4068240 YP_601738.1 CDS MGAS10750_Spy0244 NC_008024.1 254931 256112 R D-alanyl-D-alanine carboxypeptidase complement(254931..256112) Streptococcus pyogenes MGAS10750 4068241 YP_601739.1 CDS dacA2 NC_008024.1 256280 257512 R D-alanyl-D-alanine serine-type carboxypeptidase complement(256280..257512) Streptococcus pyogenes MGAS10750 4068242 YP_601740.1 CDS oppA NC_008024.1 257834 259822 D Oligopeptide-binding protein oppA 257834..259822 Streptococcus pyogenes MGAS10750 4068243 YP_601741.1 CDS oppB NC_008024.1 259875 261389 D Oligopeptide transport system permease oppB 259875..261389 Streptococcus pyogenes MGAS10750 4068244 YP_601742.1 CDS oppC NC_008024.1 261389 262315 D Oligopeptide transport system permease oppC 261389..262315 Streptococcus pyogenes MGAS10750 4068245 YP_601743.1 CDS oppD NC_008024.1 262324 263394 D peptide ABC transporter ATP-binding protein 262324..263394 Streptococcus pyogenes MGAS10750 4068246 YP_601744.1 CDS oppF NC_008024.1 263387 264310 D peptide ABC transporter ATP-binding protein 263387..264310 Streptococcus pyogenes MGAS10750 4068247 YP_601745.1 CDS MGAS10750_Spy0251 NC_008024.1 264551 264697 R transposase complement(264551..264697) Streptococcus pyogenes MGAS10750 4068248 YP_601746.1 CDS MGAS10750_Spy0252 NC_008024.1 265072 265206 R hypothetical protein complement(265072..265206) Streptococcus pyogenes MGAS10750 4068249 YP_601747.1 CDS MGAS10750_Spy0253 NC_008024.1 270694 271179 D Competence-specific sigma factor ComX 270694..271179 Streptococcus pyogenes MGAS10750 4068293 YP_601748.1 CDS MGAS10750_Spy0254 NC_008024.1 271681 272265 D lipase 271681..272265 Streptococcus pyogenes MGAS10750 4068294 YP_601749.1 CDS MGAS10750_Spy0255 NC_008024.1 272265 273383 D in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis; GTP-binding protein YqeH 272265..273383 Streptococcus pyogenes MGAS10750 4068295 YP_601750.1 CDS MGAS10750_Spy0256 NC_008024.1 273408 273716 D RNA-binding protein 273408..273716 Streptococcus pyogenes MGAS10750 4068296 YP_601751.1 CDS nadD NC_008024.1 273785 274417 D transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 273785..274417 Streptococcus pyogenes MGAS10750 4068297 YP_601752.1 CDS MGAS10750_Spy0258 NC_008024.1 274414 275007 D HAD superfamily; hydrolase 274414..275007 Streptococcus pyogenes MGAS10750 4068298 YP_601753.1 CDS MGAS10750_Spy0259 NC_008024.1 274983 275243 D Isochorismatase 274983..275243 Streptococcus pyogenes MGAS10750 4068299 YP_601754.1 CDS MGAS10750_Spy0260 NC_008024.1 275233 275598 D iojap protein family 275233..275598 Streptococcus pyogenes MGAS10750 4068300 YP_601755.1 CDS MGAS10750_Spy0261 NC_008024.1 275634 276389 D Methyltransferase 275634..276389 Streptococcus pyogenes MGAS10750 4068301 YP_601756.1 CDS MGAS10750_Spy0262 NC_008024.1 276643 277749 D hypothetical protein 276643..277749 Streptococcus pyogenes MGAS10750 4068302 YP_601757.1 CDS MGAS10750_Spy0263 NC_008024.1 278101 278241 D hypothetical protein 278101..278241 Streptococcus pyogenes MGAS10750 4068303 YP_601758.1 CDS MGAS10750_Spy0264 NC_008024.1 278231 278947 D hypothetical protein 278231..278947 Streptococcus pyogenes MGAS10750 4066977 YP_601759.1 CDS MGAS10750_Spy0265 NC_008024.1 279150 279992 D ABC transporter substrate-binding protein 279150..279992 Streptococcus pyogenes MGAS10750 4066978 YP_601760.1 CDS MGAS10750_Spy0266 NC_008024.1 280319 281164 D ABC transporter substrate-binding protein 280319..281164 Streptococcus pyogenes MGAS10750 4066979 YP_601761.1 CDS MGAS10750_Spy0267 NC_008024.1 281414 282478 D ABC transporter ATP-binding protein 281414..282478 Streptococcus pyogenes MGAS10750 4066980 YP_601762.1 CDS MGAS10750_Spy0268 NC_008024.1 282479 283171 D ABC transporter permease 282479..283171 Streptococcus pyogenes MGAS10750 4066981 YP_601763.1 CDS braB NC_008024.1 283416 284594 R Branched-chain amino acid transport system carrier protein complement(283416..284594) Streptococcus pyogenes MGAS10750 4066982 YP_601764.1 CDS MGAS10750_Spy0270 NC_008024.1 284828 286042 D involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 284828..286042 Streptococcus pyogenes MGAS10750 4066983 YP_601765.1 CDS MGAS10750_Spy0271 NC_008024.1 286097 286771 R Potassium uptake protein ktrA complement(286097..286771) Streptococcus pyogenes MGAS10750 4066984 YP_601766.1 CDS MGAS10750_Spy0272 NC_008024.1 286781 288172 R Potassium uptake protein ktrB complement(286781..288172) Streptococcus pyogenes MGAS10750 4066985 YP_601767.1 CDS gidB NC_008024.1 288241 288954 R glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB complement(288241..288954) Streptococcus pyogenes MGAS10750 4066986 YP_601768.1 CDS lemA NC_008024.1 289104 289661 D LemA protein 289104..289661 Streptococcus pyogenes MGAS10750 4066987 YP_601769.1 CDS MGAS10750_Spy0275 NC_008024.1 289708 290604 D metalloprotease; heat shock protein HtpX 289708..290604 Streptococcus pyogenes MGAS10750 4066988 YP_601770.1 CDS MGAS10750_Spy0276 NC_008024.1 290835 291371 D hypothetical protein 290835..291371 Streptococcus pyogenes MGAS10750 4066989 YP_601771.1 CDS covR NC_008024.1 291638 292324 D Response regulator CsrR 291638..292324 Streptococcus pyogenes MGAS10750 4066990 YP_601772.1 CDS covS NC_008024.1 292330 293832 D transmembrane histidine kinase CsrS 292330..293832 Streptococcus pyogenes MGAS10750 4066991 YP_601773.1 CDS nrdR NC_008024.1 294047 294541 D NrdR family transcriptional regulator 294047..294541 Streptococcus pyogenes MGAS10750 4066992 YP_601774.1 CDS dnaB NC_008024.1 294525 295700 D Replicative DNA helicase 294525..295700 Streptococcus pyogenes MGAS10750 4066993 YP_601775.1 CDS dnaI NC_008024.1 295701 296603 D Primosomal protein that may act to load helicase DnaC during DNA replication; primosomal protein DnaI 295701..296603 Streptococcus pyogenes MGAS10750 4066994 YP_601776.1 CDS engA NC_008024.1 296666 297976 D EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 296666..297976 Streptococcus pyogenes MGAS10750 4066995 YP_601777.1 CDS snf NC_008024.1 298183 301281 D SWF/SNF family helicase 298183..301281 Streptococcus pyogenes MGAS10750 4066996 YP_601778.1 CDS MGAS10750_Spy0284 NC_008024.1 301523 302125 D hypothetical protein 301523..302125 Streptococcus pyogenes MGAS10750 4068401 YP_601779.1 CDS murC NC_008024.1 302165 303493 D Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 302165..303493 Streptococcus pyogenes MGAS10750 4068402 YP_601780.1 CDS MGAS10750_Spy0286 NC_008024.1 303539 304021 D acetyltransferase, GNAT family 303539..304021 Streptococcus pyogenes MGAS10750 4068403 YP_601781.1 CDS MGAS10750_Spy0287 NC_008024.1 304133 305707 D hypothetical protein 304133..305707 Streptococcus pyogenes MGAS10750 4068404 YP_601782.1 CDS greA NC_008024.1 305732 306262 D necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 305732..306262 Streptococcus pyogenes MGAS10750 4068405 YP_601783.1 CDS MGAS10750_Spy0289 NC_008024.1 306477 306620 R transposase complement(306477..306620) Streptococcus pyogenes MGAS10750 4068406 YP_601784.1 CDS MGAS10750_Spy0290 NC_008024.1 306886 307809 R involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site; OxaA-like protein precursor complement(306886..307809) Streptococcus pyogenes MGAS10750 4068407 YP_601785.1 CDS MGAS10750_Spy0291 NC_008024.1 307891 308202 R catalyzes the hydrolysis of acylphosphate; acylphosphatase complement(307891..308202) Streptococcus pyogenes MGAS10750 4068408 YP_601786.1 CDS MGAS10750_Spy0292 NC_008024.1 308430 309167 D 23S rRNA methyltransferase 308430..309167 Streptococcus pyogenes MGAS10750 4068409 YP_601787.1 CDS MGAS10750_Spy0293 NC_008024.1 309206 309706 D HAD superfamily; hydrolase 309206..309706 Streptococcus pyogenes MGAS10750 4068410 YP_601788.1 CDS MGAS10750_Spy0294 NC_008024.1 309721 310410 D membrane protein 309721..310410 Streptococcus pyogenes MGAS10750 4068411 YP_601789.1 CDS MGAS10750_Spy0295 NC_008024.1 310588 310830 D hypothetical protein 310588..310830 Streptococcus pyogenes MGAS10750 4068412 YP_601790.1 CDS MGAS10750_Spy0296 NC_008024.1 310888 310983 R hypothetical protein complement(310888..310983) Streptococcus pyogenes MGAS10750 4068413 YP_601791.1 CDS glr NC_008024.1 311008 311802 D converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 311008..311802 Streptococcus pyogenes MGAS10750 4068414 YP_601792.1 CDS MGAS10750_Spy0298 NC_008024.1 311760 312785 D HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein 311760..312785 Streptococcus pyogenes MGAS10750 4068415 YP_601793.1 CDS MGAS10750_Spy0299 NC_008024.1 312764 313285 D phosphoesterase 312764..313285 Streptococcus pyogenes MGAS10750 4068416 YP_601794.1 CDS MGAS10750_Spy0300 NC_008024.1 313282 313743 D hypothetical protein 313282..313743 Streptococcus pyogenes MGAS10750 4068417 YP_601795.1 CDS xerD NC_008024.1 313740 314486 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD-like protein 313740..314486 Streptococcus pyogenes MGAS10750 4068418 YP_601796.1 CDS scpA NC_008024.1 314486 315190 D functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB; segregation and condensation protein A 314486..315190 Streptococcus pyogenes MGAS10750 4068419 YP_601797.1 CDS scpB NC_008024.1 315187 315738 D functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer; segregation and condensation protein B 315187..315738 Streptococcus pyogenes MGAS10750 4068381 YP_601798.1 CDS MGAS10750_Spy0304 NC_008024.1 315835 316581 D ribosomal large subunit pseudouridine synthase B 315835..316581 Streptococcus pyogenes MGAS10750 4068382 YP_601799.1 CDS MGAS10750_Spy0305 NC_008024.1 316578 316841 D hypothetical protein 316578..316841 Streptococcus pyogenes MGAS10750 4068383 YP_601800.1 CDS MGAS10750_Spy0306 NC_008024.1 316983 317567 D 23S rRNA methyltransferase 316983..317567 Streptococcus pyogenes MGAS10750 4068384 YP_601801.1 CDS MGAS10750_Spy0307 NC_008024.1 317878 318441 D riboflavin transporter 317878..318441 Streptococcus pyogenes MGAS10750 4068385 YP_601802.1 CDS MGAS10750_Spy0308 NC_008024.1 318443 319096 D Membrane-associated phospholipid phosphatase 318443..319096 Streptococcus pyogenes MGAS10750 4068386 YP_601803.1 CDS MGAS10750_Spy0309 NC_008024.1 319371 320309 D Radical SAM superfamily protein 319371..320309 Streptococcus pyogenes MGAS10750 4068387 YP_601804.1 CDS MGAS10750_Spy0310 NC_008024.1 320321 320902 D SAM-dependent methyltransferase 320321..320902 Streptococcus pyogenes MGAS10750 4068388 YP_601805.1 CDS hlyX NC_008024.1 320996 322369 D Magnesium and cobalt efflux protein corC 320996..322369 Streptococcus pyogenes MGAS10750 4068389 YP_601806.1 CDS pflC NC_008024.1 322375 323238 D Pyruvate formate-lyase activating enzyme 322375..323238 Streptococcus pyogenes MGAS10750 4068390 YP_601807.1 CDS ppaC NC_008024.1 323363 324304 D catalyzes the hydrolysis of pyrophosphate to phosphate; manganese-dependent inorganic pyrophosphatase 323363..324304 Streptococcus pyogenes MGAS10750 4068391 YP_601808.1 CDS MGAS10750_Spy0314 NC_008024.1 324380 325033 D hypothetical protein 324380..325033 Streptococcus pyogenes MGAS10750 4068392 YP_601809.1 CDS fhuG NC_008024.1 325078 326115 R ferrichrome transport system permease fhuG complement(325078..326115) Streptococcus pyogenes MGAS10750 4068393 YP_601810.1 CDS fhuB NC_008024.1 326076 327128 R ferrichrome transport system permease fhuB complement(326076..327128) Streptococcus pyogenes MGAS10750 4068394 YP_601811.1 CDS fhuD NC_008024.1 327118 328050 R ferrichrome-binding protein complement(327118..328050) Streptococcus pyogenes MGAS10750 4068395 YP_601812.1 CDS fhuA NC_008024.1 328076 328858 R ferrichrome transport ATP-binding protein fhuC complement(328076..328858) Streptococcus pyogenes MGAS10750 4068396 YP_601813.1 CDS MGAS10750_Spy0319 NC_008024.1 328951 329286 R transposase complement(328951..329286) Streptococcus pyogenes MGAS10750 4068397 YP_601814.1 CDS MGAS10750_Spy0320 NC_008024.1 329332 330447 R transposase complement(329332..330447) Streptococcus pyogenes MGAS10750 4068398 YP_601815.1 CDS murE NC_008024.1 330649 332094 R involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine; UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase complement(330649..332094) Streptococcus pyogenes MGAS10750 4068399 YP_601816.1 CDS MGAS10750_Spy0322 NC_008024.1 332182 333816 D Export protein for polysaccharides and teichoic acids 332182..333816 Streptococcus pyogenes MGAS10750 4068400 YP_601817.1 CDS upp NC_008024.1 333984 334613 D Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 333984..334613 Streptococcus pyogenes MGAS10750 4066731 YP_601818.1 CDS clpP NC_008024.1 334837 335427 D hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 334837..335427 Streptococcus pyogenes MGAS10750 4066732 YP_601819.1 CDS MGAS10750_Spy0325 NC_008024.1 335922 336215 D hypothetical protein 335922..336215 Streptococcus pyogenes MGAS10750 4066733 YP_601820.1 CDS tmk NC_008024.1 336320 337081 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 336320..337081 Streptococcus pyogenes MGAS10750 4066734 YP_601821.1 CDS dnaX NC_008024.1 337099 337974 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA.; DNA polymerase III subunit delta' 337099..337974 Streptococcus pyogenes MGAS10750 4066735 YP_601822.1 CDS MGAS10750_Spy0328 NC_008024.1 337975 338232 D Tpl protein 337975..338232 Streptococcus pyogenes MGAS10750 4066736 YP_601823.1 CDS MGAS10750_Spy0329 NC_008024.1 338321 338482 D Signal peptidase-like protein 338321..338482 Streptococcus pyogenes MGAS10750 4066737 YP_601824.1 CDS MGAS10750_Spy0330 NC_008024.1 338636 338959 D in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA; DNA replication intiation control protein YabA 338636..338959 Streptococcus pyogenes MGAS10750 4066738 YP_601825.1 CDS MGAS10750_Spy0331 NC_008024.1 338964 339245 D Tetrapyrrole (Corrin/Porphyrin) methylase family protein 338964..339245 Streptococcus pyogenes MGAS10750 4066739 YP_601826.1 CDS MGAS10750_Spy0332 NC_008024.1 339253 339828 D Tetrapyrrole (Corrin/Porphyrin) methylase family protein 339253..339828 Streptococcus pyogenes MGAS10750 4066740 YP_601827.1 CDS MGAS10750_Spy0333 NC_008024.1 339855 340247 D hypothetical protein 339855..340247 Streptococcus pyogenes MGAS10750 4066741 YP_601828.1 CDS cutC NC_008024.1 340294 340923 R Copper homeostasis protein cutC complement(340294..340923) Streptococcus pyogenes MGAS10750 4066742 YP_601829.1 CDS MGAS10750_Spy0336 NC_008024.1 341093 341263 R hypothetical protein complement(341093..341263) Streptococcus pyogenes MGAS10750 4066743 YP_601830.1 CDS MGAS10750_Spy0335 NC_008024.1 341222 341578 D arsenate reductase 341222..341578 Streptococcus pyogenes MGAS10750 4066744 YP_601831.1 CDS exoA NC_008024.1 341652 342563 R exodeoxyribonuclease III complement(341652..342563) Streptococcus pyogenes MGAS10750 4066745 YP_601832.1 CDS lctO NC_008024.1 342707 343894 D L-lactate oxidase 342707..343894 Streptococcus pyogenes MGAS10750 4066746 YP_601833.1 CDS MGAS10750_Spy0339 NC_008024.1 344160 346895 D endopeptidase lactocepin 344160..346895 Streptococcus pyogenes MGAS10750 4066747 YP_601834.1 CDS spyCEP NC_008024.1 346933 349104 D interleukin-8 protease 346933..349104 Streptococcus pyogenes MGAS10750 4066748 YP_601835.1 CDS MGAS10750_Spy0341 NC_008024.1 349426 349554 R hypothetical protein complement(349426..349554) Streptococcus pyogenes MGAS10750 4066749 YP_601836.1 CDS MGAS10750_Spy0342 NC_008024.1 349594 349773 D hypothetical protein 349594..349773 Streptococcus pyogenes MGAS10750 4068481 YP_601837.1 CDS MGAS10750_Spy0343 NC_008024.1 349876 350583 D hypothetical protein 349876..350583 Streptococcus pyogenes MGAS10750 4068482 YP_601838.1 CDS MGAS10750_Spy0344 NC_008024.1 350726 350926 D transposase 350726..350926 Streptococcus pyogenes MGAS10750 4068483 YP_601839.1 CDS MGAS10750_Spy0345 NC_008024.1 351011 351799 D transposase 351011..351799 Streptococcus pyogenes MGAS10750 4068484 YP_601840.1 CDS MGAS10750_Spy0346 NC_008024.1 351804 351944 D hypothetical protein 351804..351944 Streptococcus pyogenes MGAS10750 4068485 YP_601841.1 CDS metS NC_008024.1 352079 354079 D methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 352079..354079 Streptococcus pyogenes MGAS10750 4068486 YP_601842.1 CDS MGAS10750_Spy0348 NC_008024.1 354410 354577 D hypothetical protein 354410..354577 Streptococcus pyogenes MGAS10750 4068487 YP_601843.1 CDS nrdF NC_008024.1 354574 355587 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 354574..355587 Streptococcus pyogenes MGAS10750 4068488 YP_601844.1 CDS nrdI NC_008024.1 355591 356025 D in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 355591..356025 Streptococcus pyogenes MGAS10750 4068489 YP_601845.1 CDS nrdE1 NC_008024.1 356045 358225 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 356045..358225 Streptococcus pyogenes MGAS10750 4068490 YP_601846.1 CDS MGAS10750_Spy0352 NC_008024.1 358245 358415 D hypothetical protein 358245..358415 Streptococcus pyogenes MGAS10750 4068491 YP_601847.1 CDS spyA NC_008024.1 358431 359198 R C3 family ADP-ribosyltransferase complement(358431..359198) Streptococcus pyogenes MGAS10750 4068492 YP_601848.1 CDS MGAS10750_Spy0354 NC_008024.1 359624 360136 D hypothetical protein 359624..360136 Streptococcus pyogenes MGAS10750 4068493 YP_601849.1 CDS MGAS10750_Spy0355 NC_008024.1 360374 360811 D hypothetical protein 360374..360811 Streptococcus pyogenes MGAS10750 4068494 YP_601850.1 CDS MGAS10750_Spy0356 NC_008024.1 361044 361295 D hypothetical protein 361044..361295 Streptococcus pyogenes MGAS10750 4068495 YP_601851.1 CDS MGAS10750_Spy0357 NC_008024.1 361389 362096 R hypothetical protein complement(361389..362096) Streptococcus pyogenes MGAS10750 4068496 YP_601852.1 CDS MGAS10750_Spy0358 NC_008024.1 362610 362777 R hypothetical protein complement(362610..362777) Streptococcus pyogenes MGAS10750 4068497 YP_601853.1 CDS MGAS10750_Spy0359 NC_008024.1 363107 363577 R hypothetical protein complement(363107..363577) Streptococcus pyogenes MGAS10750 4068498 YP_601854.1 CDS MGAS10750_Spy0360 NC_008024.1 364151 364513 D hypothetical protein 364151..364513 Streptococcus pyogenes MGAS10750 4068499 YP_601855.1 CDS fabG NC_008024.1 364506 365204 D Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase 364506..365204 Streptococcus pyogenes MGAS10750 4068500 YP_601856.1 CDS MGAS10750_Spy0362 NC_008024.1 365247 366239 D NAD-dependent oxidoreductase 365247..366239 Streptococcus pyogenes MGAS10750 4068462 YP_601857.1 CDS MGAS10750_Spy0363 NC_008024.1 366566 367909 D phosphoglycerate transporter protein 366566..367909 Streptococcus pyogenes MGAS10750 4068463 YP_601858.1 CDS glmU NC_008024.1 368082 369464 D forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 368082..369464 Streptococcus pyogenes MGAS10750 4068464 YP_601859.1 CDS MGAS10750_Spy0365 NC_008024.1 369495 370049 D ADP-ribose pyrophosphatase 369495..370049 Streptococcus pyogenes MGAS10750 4068465 YP_601860.1 CDS MGAS10750_Spy0366 NC_008024.1 370046 370300 D hypothetical protein 370046..370300 Streptococcus pyogenes MGAS10750 4068466 YP_601861.1 CDS pfs NC_008024.1 370320 371015 D enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 370320..371015 Streptococcus pyogenes MGAS10750 4068467 YP_601862.1 CDS MGAS10750_Spy0368 NC_008024.1 371166 371507 D hypothetical protein 371166..371507 Streptococcus pyogenes MGAS10750 4068468 YP_601863.1 CDS scaR NC_008024.1 371604 372251 R Iron-dependent repressor complement(371604..372251) Streptococcus pyogenes MGAS10750 4068469 YP_601864.1 CDS mtsA NC_008024.1 372394 373329 D Manganese-binding protein 372394..373329 Streptococcus pyogenes MGAS10750 4068470 YP_601865.1 CDS mtsB NC_008024.1 373366 374118 D Manganese transport system ATP-binding protein 373366..374118 Streptococcus pyogenes MGAS10750 4068471 YP_601866.1 CDS mtsC NC_008024.1 374119 374973 D Manganese transport system membrane protein 374119..374973 Streptococcus pyogenes MGAS10750 4068472 YP_601867.1 CDS MGAS10750_Spy0373 NC_008024.1 375121 375927 R Peptidyl-prolyl cis-trans isomerase complement(375121..375927) Streptococcus pyogenes MGAS10750 4068473 YP_601868.1 CDS ftsK NC_008024.1 376144 378549 D cell division protein ftsK 376144..378549 Streptococcus pyogenes MGAS10750 4068474 YP_601869.1 CDS MGAS10750_Spy0375 NC_008024.1 378619 378972 R membrane protein complement(378619..378972) Streptococcus pyogenes MGAS10750 4068475 YP_601870.2 CDS rplK NC_008024.1 379216 379641 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 379216..379641 Streptococcus pyogenes MGAS10750 4068476 YP_601871.1 CDS rplA NC_008024.1 379747 380436 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 379747..380436 Streptococcus pyogenes MGAS10750 4068477 YP_601872.1 CDS pyrH NC_008024.1 380758 381486 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 380758..381486 Streptococcus pyogenes MGAS10750 4068478 YP_601873.1 CDS frr NC_008024.1 381515 382072 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 381515..382072 Streptococcus pyogenes MGAS10750 4068479 YP_601874.1 CDS MGAS10750_Spy0380 NC_008024.1 382181 383038 D S1 RNA binding domain 382181..383038 Streptococcus pyogenes MGAS10750 4068480 YP_601875.1 CDS msrA2 NC_008024.1 383149 383619 D this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 383149..383619 Streptococcus pyogenes MGAS10750 4068361 YP_601876.1 CDS MGAS10750_Spy0382 NC_008024.1 383616 383831 D hypothetical protein 383616..383831 Streptococcus pyogenes MGAS10750 4068362 YP_601877.1 CDS MGAS10750_Spy0383 NC_008024.1 383987 385168 D Surface antigen 383987..385168 Streptococcus pyogenes MGAS10750 4068363 YP_601878.1 CDS MGAS10750_Spy0384 NC_008024.1 385409 387256 D in group A Streptococci this protein was found to cross react with anti myosin antibodies and may play a role in rheumatic fever; myosin-cross-reactive antigen 385409..387256 Streptococcus pyogenes MGAS10750 4068364 YP_601879.1 CDS phoH NC_008024.1 387415 388467 D PhoH protein 387415..388467 Streptococcus pyogenes MGAS10750 4068365 YP_601880.1 CDS MGAS10750_Spy0386 NC_008024.1 388513 389088 D uracil DNA glycosylase 388513..389088 Streptococcus pyogenes MGAS10750 4068366 YP_601881.1 CDS MGAS10750_Spy0387 NC_008024.1 389196 389744 D metalloprotease 389196..389744 Streptococcus pyogenes MGAS10750 4068367 YP_601882.1 CDS dgk NC_008024.1 389725 390132 D Diacylglycerol kinase 389725..390132 Streptococcus pyogenes MGAS10750 4068368 YP_601883.1 CDS era NC_008024.1 390252 391148 D Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 390252..391148 Streptococcus pyogenes MGAS10750 4068369 YP_601884.1 CDS MGAS10750_Spy0390 NC_008024.1 391123 391644 D MutT/nudix family protein; phosphohydrolase 391123..391644 Streptococcus pyogenes MGAS10750 4068370 YP_601885.1 CDS MGAS10750_Spy0391 NC_008024.1 391949 392203 R hypothetical protein complement(391949..392203) Streptococcus pyogenes MGAS10750 4068371 YP_601886.1 CDS MGAS10750_Spy0392 NC_008024.1 392504 392722 D Response regulator FasA 392504..392722 Streptococcus pyogenes MGAS10750 4068372 YP_601887.1 CDS MGAS10750_Spy0393 NC_008024.1 392805 393251 R bacteriocin ABC transporter complement(392805..393251) Streptococcus pyogenes MGAS10750 4068373 YP_601888.1 CDS MGAS10750_Spy0394 NC_008024.1 393474 394184 R bacteriocin ABC transporter complement(393474..394184) Streptococcus pyogenes MGAS10750 4068374 YP_601889.1 CDS MGAS10750_Spy0395 NC_008024.1 394289 394525 R Bacteriocin processing peptidase complement(394289..394525) Streptococcus pyogenes MGAS10750 4068375 YP_601890.1 CDS MGAS10750_Spy0396 NC_008024.1 394706 395047 D hypothetical protein 394706..395047 Streptococcus pyogenes MGAS10750 4068376 YP_601891.1 CDS MGAS10750_Spy0397 NC_008024.1 395025 395201 D hypothetical protein 395025..395201 Streptococcus pyogenes MGAS10750 4068377 YP_601892.1 CDS MGAS10750_Spy0398 NC_008024.1 396414 396644 D hypothetical protein 396414..396644 Streptococcus pyogenes MGAS10750 4068378 YP_601893.1 CDS MGAS10750_Spy0399 NC_008024.1 396681 397010 D hypothetical protein 396681..397010 Streptococcus pyogenes MGAS10750 4068379 YP_601894.1 CDS MGAS10750_Spy0400 NC_008024.1 397076 397357 D transposase 397076..397357 Streptococcus pyogenes MGAS10750 4068380 YP_601895.1 CDS MGAS10750_Spy0401 NC_008024.1 397390 397686 D transposase 397390..397686 Streptococcus pyogenes MGAS10750 4068157 YP_601896.1 CDS MGAS10750_Spy0402 NC_008024.1 397789 398103 D transposase 397789..398103 Streptococcus pyogenes MGAS10750 4068158 YP_601897.1 CDS MGAS10750_Spy0403 NC_008024.1 398592 399341 D Response regulator FasA 398592..399341 Streptococcus pyogenes MGAS10750 4068159 YP_601898.1 CDS MGAS10750_Spy0404 NC_008024.1 399342 400676 D Sensory transduction protein kinase 399342..400676 Streptococcus pyogenes MGAS10750 4068160 YP_601899.1 CDS MGAS10750_Spy0405 NC_008024.1 400824 400949 R hypothetical protein complement(400824..400949) Streptococcus pyogenes MGAS10750 4068161 YP_601900.1 CDS MGAS10750_Spy0406 NC_008024.1 401026 401643 R Bacteriocin export accessory protein complement(401026..401643) Streptococcus pyogenes MGAS10750 4068162 YP_601901.1 CDS MGAS10750_Spy0407 NC_008024.1 401950 402408 R Bacteriocin export accessory protein complement(401950..402408) Streptococcus pyogenes MGAS10750 4068163 YP_601902.1 CDS MGAS10750_Spy0408 NC_008024.1 402401 404554 R bacteriocin ABC transporter complement(402401..404554) Streptococcus pyogenes MGAS10750 4068164 YP_601903.1 CDS MGAS10750_Spy0409 NC_008024.1 404793 405065 D Bacteriocin 404793..405065 Streptococcus pyogenes MGAS10750 4068165 YP_601904.1 CDS MGAS10750_Spy0410 NC_008024.1 405078 405275 D hypothetical protein 405078..405275 Streptococcus pyogenes MGAS10750 4068166 YP_601905.1 CDS silD NC_008024.1 405636 405764 D hypothetical protein 405636..405764 Streptococcus pyogenes MGAS10750 4068167 YP_601906.1 CDS MGAS10750_Spy0412 NC_008024.1 405814 406095 D hypothetical protein 405814..406095 Streptococcus pyogenes MGAS10750 4068168 YP_601907.1 CDS MGAS10750_Spy0413 NC_008024.1 406289 406699 D hypothetical protein 406289..406699 Streptococcus pyogenes MGAS10750 4068169 YP_601908.1 CDS MGAS10750_Spy0414 NC_008024.1 406729 406845 R hypothetical protein complement(406729..406845) Streptococcus pyogenes MGAS10750 4068170 YP_601909.1 CDS MGAS10750_Spy0415 NC_008024.1 406941 408011 D hypothetical protein 406941..408011 Streptococcus pyogenes MGAS10750 4068171 YP_601910.1 CDS MGAS10750_Spy0416 NC_008024.1 408104 408502 D hypothetical protein 408104..408502 Streptococcus pyogenes MGAS10750 4068172 YP_601911.1 CDS MGAS10750_Spy0417 NC_008024.1 408850 409119 R hypothetical protein complement(408850..409119) Streptococcus pyogenes MGAS10750 4068173 YP_601912.1 CDS MGAS10750_Spy0418 NC_008024.1 409320 409427 D hypothetical protein 409320..409427 Streptococcus pyogenes MGAS10750 4068174 YP_601913.1 CDS MGAS10750_Spy0419 NC_008024.1 409543 409692 R hypothetical protein complement(409543..409692) Streptococcus pyogenes MGAS10750 4068175 YP_601914.1 CDS mutR NC_008024.1 410175 411056 D transcriptional regulator 410175..411056 Streptococcus pyogenes MGAS10750 4068137 YP_601915.1 CDS fpg NC_008024.1 411228 412055 D Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 411228..412055 Streptococcus pyogenes MGAS10750 4068138 YP_601916.1 CDS coaE NC_008024.1 412025 412645 D catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 412025..412645 Streptococcus pyogenes MGAS10750 4068139 YP_601917.1 CDS MGAS10750_Spy0423 NC_008024.1 412835 414337 D ATPase 412835..414337 Streptococcus pyogenes MGAS10750 4068140 YP_601918.1 CDS MGAS10750_Spy0424 NC_008024.1 414459 415652 D multidrug resistance efflux pump 414459..415652 Streptococcus pyogenes MGAS10750 4068141 YP_601919.1 CDS rpmG NC_008024.1 415649 415795 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 415649..415795 Streptococcus pyogenes MGAS10750 4068142 YP_601920.1 CDS secG NC_008024.1 415841 416077 D preprotein translocase subunit SecG 415841..416077 Streptococcus pyogenes MGAS10750 4068143 YP_601921.1 CDS MGAS10750_Spy0427 NC_008024.1 416171 418504 D exoribonuclease II 416171..418504 Streptococcus pyogenes MGAS10750 4068144 YP_601922.1 CDS smpB NC_008024.1 418507 418974 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 418507..418974 Streptococcus pyogenes MGAS10750 4068145 YP_601923.1 CDS MGAS10750_Spy0429 NC_008024.1 418989 419699 D glutaminyl-peptide cyclotransferase 418989..419699 Streptococcus pyogenes MGAS10750 4068146 YP_601924.1 CDS pcp NC_008024.1 419814 420461 R catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase complement(419814..420461) Streptococcus pyogenes MGAS10750 4068147 YP_601925.1 CDS MGAS10750_Spy0431 NC_008024.1 420511 421437 R Permease complement(420511..421437) Streptococcus pyogenes MGAS10750 4068148 YP_601926.1 CDS MGAS10750_Spy0432 NC_008024.1 421437 422177 R Permease complement(421437..422177) Streptococcus pyogenes MGAS10750 4068149 YP_601927.1 CDS MGAS10750_Spy0433 NC_008024.1 422331 423317 R Bactoprenol glucosyl transferase complement(422331..423317) Streptococcus pyogenes MGAS10750 4068150 YP_601928.1 CDS gloA NC_008024.1 423402 423779 R Lactoylglutathione lyase complement(423402..423779) Streptococcus pyogenes MGAS10750 4068151 YP_601929.1 CDS MGAS10750_Spy0435 NC_008024.1 423790 424455 R NAD(P)H-dependent quinone reductase complement(423790..424455) Streptococcus pyogenes MGAS10750 4068152 YP_601930.1 CDS pepQ NC_008024.1 424504 425589 R Xaa-Pro aminopeptidase complement(424504..425589) Streptococcus pyogenes MGAS10750 4068153 YP_601931.1 CDS ccpA NC_008024.1 425763 426764 D Catabolite control protein A 425763..426764 Streptococcus pyogenes MGAS10750 4068154 YP_601932.1 CDS MGAS10750_Spy0438 NC_008024.1 426895 427893 D glycosyltransferase 426895..427893 Streptococcus pyogenes MGAS10750 4068155 YP_601933.1 CDS MGAS10750_Spy0439 NC_008024.1 427895 429229 D 1,2-diacylglycerol 3-glucosyltransferase 427895..429229 Streptococcus pyogenes MGAS10750 4068156 YP_601934.1 CDS thrS NC_008024.1 429651 431594 D catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 429651..431594 Streptococcus pyogenes MGAS10750 4068118 YP_601935.1 CDS drrA NC_008024.1 431735 432448 D Daunorubicin resistance ATP-binding protein drrA 431735..432448 Streptococcus pyogenes MGAS10750 4068119 YP_601936.1 CDS MGAS10750_Spy0442 NC_008024.1 432423 432728 D Daunorubicin resistance ATP-binding protein drrA 432423..432728 Streptococcus pyogenes MGAS10750 4068120 YP_601937.1 CDS MGAS10750_Spy0443 NC_008024.1 432730 433548 D Daunorubicin resistance transmembrane protein 432730..433548 Streptococcus pyogenes MGAS10750 4068121 YP_601938.1 CDS MGAS10750_Spy0444 NC_008024.1 433550 434335 D ABC transporter permease 433550..434335 Streptococcus pyogenes MGAS10750 4068122 YP_601939.1 CDS MGAS10750_Spy0445 NC_008024.1 434439 435488 R similar to DhaK; in Lactococcus lactis this protein froms a stable complex with DhaS and activates transcription of the dha operon in the presence of dihydroxyacetone; DhaKLM operon coactivator DhaQ complement(434439..435488) Streptococcus pyogenes MGAS10750 4068123 YP_601940.1 CDS MGAS10750_Spy0446 NC_008024.1 435443 435979 R TetR family transcriptional regulator complement(435443..435979) Streptococcus pyogenes MGAS10750 4068124 YP_601941.1 CDS MGAS10750_Spy0447 NC_008024.1 436131 437120 D with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK 436131..437120 Streptococcus pyogenes MGAS10750 4068125 YP_601942.1 CDS MGAS10750_Spy0448 NC_008024.1 437062 437706 D dihydroxyacetone kinase 437062..437706 Streptococcus pyogenes MGAS10750 4068126 YP_601943.1 CDS MGAS10750_Spy0449 NC_008024.1 437706 438080 D phosphotransferase mannnose-specific family component IIA 437706..438080 Streptococcus pyogenes MGAS10750 4068127 YP_601944.1 CDS MGAS10750_Spy0450 NC_008024.1 438098 438808 D glycerol uptake facilitator protein 438098..438808 Streptococcus pyogenes MGAS10750 4068128 YP_601945.1 CDS MGAS10750_Spy0451 NC_008024.1 438931 439512 D hypothetical protein 438931..439512 Streptococcus pyogenes MGAS10750 4068129 YP_601946.1 CDS MGAS10750_Spy0452 NC_008024.1 439475 440569 D acetyl-CoA acetyltransferase 439475..440569 Streptococcus pyogenes MGAS10750 4068130 YP_601947.1 CDS MGAS10750_Spy0453 NC_008024.1 440587 441834 D Long-chain-fatty-acid--CoA ligase 440587..441834 Streptococcus pyogenes MGAS10750 4068131 YP_601948.1 CDS MGAS10750_Spy0454 NC_008024.1 441890 442924 D hypothetical protein 441890..442924 Streptococcus pyogenes MGAS10750 4068132 YP_601949.1 CDS vicR NC_008024.1 443086 443796 D two-component response regulator VicR 443086..443796 Streptococcus pyogenes MGAS10750 4068133 YP_601950.1 CDS vicK NC_008024.1 443789 445141 D two-component sensor histidine kinase VicK 443789..445141 Streptococcus pyogenes MGAS10750 4068134 YP_601951.1 CDS vicX NC_008024.1 445145 445954 D beta-lactamase superfamily; Zn-dependent hydrolase 445145..445954 Streptococcus pyogenes MGAS10750 4068135 YP_601952.1 CDS rnc NC_008024.1 446397 447089 D cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 446397..447089 Streptococcus pyogenes MGAS10750 4068136 YP_601953.1 CDS smc NC_008024.1 447090 450629 D chromosome partition protein smc 447090..450629 Streptococcus pyogenes MGAS10750 4068098 YP_601954.1 CDS MGAS10750_Spy0460 NC_008024.1 450882 451754 R transcriptional regulator complement(450882..451754) Streptococcus pyogenes MGAS10750 4068099 YP_601955.1 CDS aroE NC_008024.1 451953 452879 D AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 451953..452879 Streptococcus pyogenes MGAS10750 4068100 YP_601956.1 CDS MGAS10750_Spy0462 NC_008024.1 452876 453712 D hypothetical protein 452876..453712 Streptococcus pyogenes MGAS10750 4068101 YP_601957.1 CDS MGAS10750_Spy0463 NC_008024.1 453690 454448 D hypothetical protein 453690..454448 Streptococcus pyogenes MGAS10750 4068102 YP_601958.1 CDS MGAS10750_Spy0464 NC_008024.1 454441 455427 D hypothetical protein 454441..455427 Streptococcus pyogenes MGAS10750 4068103 YP_601959.1 CDS metK1 NC_008024.1 455437 456636 D catalyzes the formation of S-adenosylmethionine from methionine and ATP; S-adenosylmethionine synthetase 455437..456636 Streptococcus pyogenes MGAS10750 4068104 YP_601960.1 CDS MGAS10750_Spy0466 NC_008024.1 456620 457588 D hypothetical protein 456620..457588 Streptococcus pyogenes MGAS10750 4068105 YP_601961.1 CDS MGAS10750_Spy0467 NC_008024.1 457643 458632 D cell wall biogenesis glycosyltransferase 457643..458632 Streptococcus pyogenes MGAS10750 4068106 YP_601962.1 CDS MGAS10750_Spy0468 NC_008024.1 459035 459301 D hypothetical protein 459035..459301 Streptococcus pyogenes MGAS10750 4068107 YP_601963.1 CDS hasB NC_008024.1 459325 460482 D UDP-glucose 6-dehydrogenase 459325..460482 Streptococcus pyogenes MGAS10750 4068108 YP_601964.1 CDS mefE NC_008024.1 460567 461775 D Macrolide-efflux protein 460567..461775 Streptococcus pyogenes MGAS10750 4068109 YP_601965.1 CDS MGAS10750_Spy0471 NC_008024.1 461877 462086 R transcriptional regulator complement(461877..462086) Streptococcus pyogenes MGAS10750 4068110 YP_601966.1 CDS MGAS10750_Spy0472 NC_008024.1 462076 462921 R chromosome segregation ATPase complement(462076..462921) Streptococcus pyogenes MGAS10750 4068111 YP_601967.1 CDS MGAS10750_Spy0473 NC_008024.1 463006 463734 R chromosome segregation ATPase complement(463006..463734) Streptococcus pyogenes MGAS10750 4068112 YP_601968.1 CDS MGAS10750_Spy0474 NC_008024.1 463725 463949 R hypothetical protein complement(463725..463949) Streptococcus pyogenes MGAS10750 4068113 YP_601969.1 CDS MGAS10750_Spy0476 NC_008024.1 463949 465049 R hypothetical protein complement(463949..465049) Streptococcus pyogenes MGAS10750 4068114 YP_601970.1 CDS MGAS10750_Spy0475 NC_008024.1 465035 465391 D plasmid stabilization system antitoxin protein 465035..465391 Streptococcus pyogenes MGAS10750 4068115 YP_601971.1 CDS MGAS10750_Spy0477 NC_008024.1 465391 465696 D plasmid stabilization system toxin protein 465391..465696 Streptococcus pyogenes MGAS10750 4068116 YP_601972.1 CDS MGAS10750_Spy0478 NC_008024.1 465715 465846 D hypothetical protein 465715..465846 Streptococcus pyogenes MGAS10750 4068117 YP_601973.1 CDS MGAS10750_Spy0479 NC_008024.1 466149 466490 D Portal protein 466149..466490 Streptococcus pyogenes MGAS10750 4068079 YP_601974.1 CDS MGAS10750_Spy0480 NC_008024.1 466555 466863 D hypothetical protein 466555..466863 Streptococcus pyogenes MGAS10750 4068080 YP_601975.1 CDS MGAS10750_Spy0481 NC_008024.1 467265 467606 D hypothetical protein 467265..467606 Streptococcus pyogenes MGAS10750 4068081 YP_601976.1 CDS MGAS10750_Spy0482 NC_008024.1 467630 468454 D AS-AR; AsnRS2; similar to asparaginyl-tRNA synthetase but lacking the N-terminal anticodon-binding site; the enzyme from Pyrococcus converts aspartic acid into asparagine; asparagine synthetase A 467630..468454 Streptococcus pyogenes MGAS10750 4068082 YP_601977.1 CDS MGAS10750_Spy0483 NC_008024.1 468432 469043 D hypothetical protein 468432..469043 Streptococcus pyogenes MGAS10750 4068083 YP_601978.1 CDS MGAS10750_Spy0484 NC_008024.1 469147 469365 D hypothetical protein 469147..469365 Streptococcus pyogenes MGAS10750 4068084 YP_601979.1 CDS mccF NC_008024.1 469637 470656 D Microcin C7 self-immunity protein mccF 469637..470656 Streptococcus pyogenes MGAS10750 4068085 YP_601980.1 CDS MGAS10750_Spy0486 NC_008024.1 470669 470869 D hypothetical protein 470669..470869 Streptococcus pyogenes MGAS10750 4068086 YP_601981.1 CDS MGAS10750_Spy0487 NC_008024.1 470989 471474 D hypothetical protein 470989..471474 Streptococcus pyogenes MGAS10750 4068087 YP_601982.1 CDS MGAS10750_Spy0488 NC_008024.1 471471 471887 D hypothetical protein 471471..471887 Streptococcus pyogenes MGAS10750 4068088 YP_601983.1 CDS MGAS10750_Spy0489 NC_008024.1 472261 472830 R transposase complement(472261..472830) Streptococcus pyogenes MGAS10750 4068089 YP_601984.1 CDS MGAS10750_Spy0490 NC_008024.1 473111 473431 R transposase complement(473111..473431) Streptococcus pyogenes MGAS10750 4068090 YP_601985.1 CDS MGAS10750_Spy0491 NC_008024.1 473514 473687 R hypothetical protein complement(473514..473687) Streptococcus pyogenes MGAS10750 4068091 YP_601986.1 CDS MGAS10750_Spy0492 NC_008024.1 473691 474488 D HAD superfamily; hydrolase 473691..474488 Streptococcus pyogenes MGAS10750 4068092 YP_601987.1 CDS MGAS10750_Spy0493 NC_008024.1 474492 475316 D HAD superfamily; hydrolase 474492..475316 Streptococcus pyogenes MGAS10750 4068093 YP_601988.1 CDS ftsY NC_008024.1 475316 476866 D cell division protein ftsY 475316..476866 Streptococcus pyogenes MGAS10750 4068094 YP_601989.1 CDS MGAS10750_Spy0495 NC_008024.1 476920 478287 R multidrug resistance protein B complement(476920..478287) Streptococcus pyogenes MGAS10750 4068095 YP_601990.1 CDS licT NC_008024.1 478615 479457 D transcription antiterminator, BglG family 478615..479457 Streptococcus pyogenes MGAS10750 4068096 YP_601991.1 CDS MGAS10750_Spy0497 NC_008024.1 479459 481321 D PTS system, beta-glucoside-specific IIABC component 479459..481321 Streptococcus pyogenes MGAS10750 4068097 YP_601992.1 CDS bglA NC_008024.1 481340 482764 D 6-phospho-beta-glucosidase 481340..482764 Streptococcus pyogenes MGAS10750 4068059 YP_601993.1 CDS MGAS10750_Spy0499 NC_008024.1 482863 483702 R hypothetical protein complement(482863..483702) Streptococcus pyogenes MGAS10750 4068060 YP_601994.1 CDS MGAS10750_Spy0500 NC_008024.1 483678 484580 R hypothetical protein complement(483678..484580) Streptococcus pyogenes MGAS10750 4068061 YP_601995.1 CDS MGAS10750_Spy0501 NC_008024.1 484714 484911 D hypothetical protein 484714..484911 Streptococcus pyogenes MGAS10750 4068062 YP_601996.1 CDS MGAS10750_Spy0502 NC_008024.1 485096 487249 D S1 RNA binding domain; transcription accessory protein 485096..487249 Streptococcus pyogenes MGAS10750 4068063 YP_601997.1 CDS MGAS10750_Spy0503 NC_008024.1 487236 487673 D hypothetical protein 487236..487673 Streptococcus pyogenes MGAS10750 4068064 YP_601998.1 CDS MGAS10750_Spy0504 NC_008024.1 487737 488009 D Stress-responsive transcriptional regulator PspC 487737..488009 Streptococcus pyogenes MGAS10750 4068065 YP_601999.2 CDS ptsK NC_008024.1 488314 489306 D catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase 488314..489306 Streptococcus pyogenes MGAS10750 4068066 YP_602000.1 CDS lgt NC_008024.1 489303 490082 D transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 489303..490082 Streptococcus pyogenes MGAS10750 4068067 YP_602001.1 CDS MGAS10750_Spy0507 NC_008024.1 490104 490511 D hypothetical protein 490104..490511 Streptococcus pyogenes MGAS10750 4068068 YP_602002.1 CDS MGAS10750_Spy0508 NC_008024.1 490483 490932 D hypothetical protein 490483..490932 Streptococcus pyogenes MGAS10750 4068069 YP_602003.1 CDS MGAS10750_Spy0509 NC_008024.1 491093 491377 R hypothetical protein complement(491093..491377) Streptococcus pyogenes MGAS10750 4068070 YP_602004.1 CDS MGAS10750_Spy0510 NC_008024.1 491576 492502 D Peptidase family U32 491576..492502 Streptococcus pyogenes MGAS10750 4068071 YP_602005.1 CDS MGAS10750_Spy0511 NC_008024.1 492604 493890 D Peptidase family U32 492604..493890 Streptococcus pyogenes MGAS10750 4068072 YP_602006.1 CDS MGAS10750_Spy0512 NC_008024.1 494095 494307 D hypothetical protein 494095..494307 Streptococcus pyogenes MGAS10750 4068073 YP_602007.1 CDS MGAS10750_Spy0513 NC_008024.1 494404 494544 R hypothetical protein complement(494404..494544) Streptococcus pyogenes MGAS10750 4068074 YP_602008.1 CDS lysS NC_008024.1 494680 496185 R class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(494680..496185) Streptococcus pyogenes MGAS10750 4068075 YP_602009.1 CDS MGAS10750_Spy0515 NC_008024.1 496347 497249 D Haloacid dehalogenase-like hydrolase 496347..497249 Streptococcus pyogenes MGAS10750 4068076 YP_602010.1 CDS MGAS10750_Spy0516 NC_008024.1 497357 497980 R phosphoglycerate mutase family protein complement(497357..497980) Streptococcus pyogenes MGAS10750 4068077 YP_602011.1 CDS MGAS10750_Spy0517 NC_008024.1 498056 498535 R transcriptional regulator complement(498056..498535) Streptococcus pyogenes MGAS10750 4068078 YP_602012.1 CDS MGAS10750_Spy0518 NC_008024.1 498628 499236 R Thiamine transporter complement(498628..499236) Streptococcus pyogenes MGAS10750 4068040 YP_602013.1 CDS MGAS10750_Spy0519 NC_008024.1 499459 500307 R N-acetylmuramoyl-L-alanine amidase complement(499459..500307) Streptococcus pyogenes MGAS10750 4068041 YP_602014.1 CDS MGAS10750_Spy0520 NC_008024.1 500632 501135 D membrane protein 500632..501135 Streptococcus pyogenes MGAS10750 4068042 YP_602015.1 CDS MGAS10750_Spy0521 NC_008024.1 501119 501502 D hypothetical protein 501119..501502 Streptococcus pyogenes MGAS10750 4068043 YP_602016.1 CDS MGAS10750_Spy0522 NC_008024.1 501548 502072 R glutathione peroxidase complement(501548..502072) Streptococcus pyogenes MGAS10750 4068044 YP_602017.1 CDS pepF NC_008024.1 502020 503894 R Oligoendopeptidase F complement(502020..503894) Streptococcus pyogenes MGAS10750 4068045 YP_602018.1 CDS ppc NC_008024.1 503963 506776 D catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 503963..506776 Streptococcus pyogenes MGAS10750 4068046 YP_602019.1 CDS ftsW NC_008024.1 506916 508220 D cell division protein ftsW 506916..508220 Streptococcus pyogenes MGAS10750 4068047 YP_602020.1 CDS MGAS10750_Spy0526 NC_008024.1 508237 508377 R hypothetical protein complement(508237..508377) Streptococcus pyogenes MGAS10750 4068048 YP_602021.2 CDS tuf NC_008024.1 508575 509771 D EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 508575..509771 Streptococcus pyogenes MGAS10750 4068049 YP_602022.1 CDS tpiA NC_008024.1 510012 510770 D Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 510012..510770 Streptococcus pyogenes MGAS10750 4068050 YP_602023.1 CDS MGAS10750_Spy0529 NC_008024.1 510869 512104 R Factor essential for expression of methicillin resistance complement(510869..512104) Streptococcus pyogenes MGAS10750 4068051 YP_602024.1 CDS murM NC_008024.1 512091 513332 R bifunctional; UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase / UDP-N-acetylmuramoylpentapeptide-lysine N(6)-seryltransferase complement(512091..513332) Streptococcus pyogenes MGAS10750 4068052 YP_602025.1 CDS MGAS10750_Spy0531 NC_008024.1 513317 514126 R HAD superfamily; hydrolase complement(513317..514126) Streptococcus pyogenes MGAS10750 4068053 YP_602026.1 CDS MGAS10750_Spy0532 NC_008024.1 514276 514509 R hypothetical protein complement(514276..514509) Streptococcus pyogenes MGAS10750 4068054 YP_602027.1 CDS MGAS10750_Spy0533 NC_008024.1 514581 515882 R dGTP triphosphohydrolase complement(514581..515882) Streptococcus pyogenes MGAS10750 4068055 YP_602028.1 CDS MGAS10750_Spy0534 NC_008024.1 515973 516359 D hypothetical protein 515973..516359 Streptococcus pyogenes MGAS10750 4068056 YP_602029.1 CDS pacL NC_008024.1 516590 519271 D Calcium-transporting ATPase 516590..519271 Streptococcus pyogenes MGAS10750 4068057 YP_602030.1 CDS regR NC_008024.1 519355 520359 R LacI family transcriptional regulator complement(519355..520359) Streptococcus pyogenes MGAS10750 4068058 YP_602031.1 CDS MGAS10750_Spy0537 NC_008024.1 520414 522339 R Oligohyaluronate lyase complement(520414..522339) Streptococcus pyogenes MGAS10750 4068020 YP_602032.1 CDS agaD NC_008024.1 522408 523289 R PTS system, N-acetylgalactosamine-specific IID component complement(522408..523289) Streptococcus pyogenes MGAS10750 4068021 YP_602033.1 CDS MGAS10750_Spy0539 NC_008024.1 523216 523998 R PTS system, N-acetylgalactosamine-specific IIC component complement(523216..523998) Streptococcus pyogenes MGAS10750 4068022 YP_602034.1 CDS agaV NC_008024.1 524017 524505 R PTS system, N-acetylgalactosamine-specific IIB component complement(524017..524505) Streptococcus pyogenes MGAS10750 4068023 YP_602035.1 CDS MGAS10750_Spy0541 NC_008024.1 524541 525740 R Unsaturated glucuronyl hydrolase complement(524541..525740) Streptococcus pyogenes MGAS10750 4068024 YP_602036.1 CDS MGAS10750_Spy0542 NC_008024.1 525807 526331 D hypothetical protein 525807..526331 Streptococcus pyogenes MGAS10750 4068025 YP_602037.1 CDS idnO NC_008024.1 526511 527305 D Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase 526511..527305 Streptococcus pyogenes MGAS10750 4068026 YP_602038.1 CDS MGAS10750_Spy0544 NC_008024.1 527330 527971 D hypothetical protein 527330..527971 Streptococcus pyogenes MGAS10750 4068027 YP_602039.1 CDS MGAS10750_Spy0545 NC_008024.1 527961 529001 D 2-dehydro-3-deoxygluconokinase 527961..529001 Streptococcus pyogenes MGAS10750 4068028 YP_602040.1 CDS kgdA NC_008024.1 528988 529641 D catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 528988..529641 Streptococcus pyogenes MGAS10750 4068029 YP_602041.1 CDS MGAS10750_Spy0547 NC_008024.1 529931 530587 D bifunctional; beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase 529931..530587 Streptococcus pyogenes MGAS10750 4068030 YP_602042.1 CDS MGAS10750_Spy0548 NC_008024.1 531227 532402 D iron-sulfur cluster-binding protein 531227..532402 Streptococcus pyogenes MGAS10750 4068031 YP_602043.1 CDS prfB NC_008024.1 532556 533569 D recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 532556..533569 Streptococcus pyogenes MGAS10750 4068032 YP_602044.1 CDS ftsE NC_008024.1 533588 534280 D cell division ATP-binding protein ftsE 533588..534280 Streptococcus pyogenes MGAS10750 4068033 YP_602045.1 CDS ftsX NC_008024.1 534243 535202 D cell division protein ftsX 534243..535202 Streptococcus pyogenes MGAS10750 4068034 YP_602046.1 CDS MGAS10750_Spy0552 NC_008024.1 535512 536171 R hydroxyacylglutathione hydrolase complement(535512..536171) Streptococcus pyogenes MGAS10750 4068035 YP_602047.1 CDS MGAS10750_Spy0553 NC_008024.1 536352 537143 D bifunctional; acetoin reductase 536352..537143 Streptococcus pyogenes MGAS10750 4068036 YP_602048.1 CDS dinG NC_008024.1 537251 539752 D unwinds DNA; bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon 537251..539752 Streptococcus pyogenes MGAS10750 4068037 YP_602049.1 CDS aspC NC_008024.1 540088 541281 D catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 540088..541281 Streptococcus pyogenes MGAS10750 4068038 YP_602050.1 CDS asnC NC_008024.1 541302 542648 D catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 541302..542648 Streptococcus pyogenes MGAS10750 4068039 YP_602051.1 CDS MGAS10750_Spy0557 NC_008024.1 543062 543952 D contains P-loop; hypothetical protein 543062..543952 Streptococcus pyogenes MGAS10750 4068001 YP_602052.1 CDS MGAS10750_Spy0558 NC_008024.1 543949 544926 D hypothetical protein 543949..544926 Streptococcus pyogenes MGAS10750 4068002 YP_602053.1 CDS MGAS10750_Spy0559 NC_008024.1 544923 545834 D hypothetical protein 544923..545834 Streptococcus pyogenes MGAS10750 4068003 YP_602054.1 CDS MGAS10750_Spy0560 NC_008024.1 546031 547446 R Site-specific recombinase complement(546031..547446) Streptococcus pyogenes MGAS10750 4068004 YP_602055.1 CDS MGAS10750_Spy0561 NC_008024.1 547597 548199 R phage protein complement(547597..548199) Streptococcus pyogenes MGAS10750 4068005 YP_602056.1 CDS MGAS10750_Spy0562 NC_008024.1 548165 548914 R phage transcriptional repressor complement(548165..548914) Streptococcus pyogenes MGAS10750 4068006 YP_602057.1 CDS MGAS10750_Spy0563 NC_008024.1 549301 549459 D phage protein 549301..549459 Streptococcus pyogenes MGAS10750 4068007 YP_602058.1 CDS MGAS10750_Spy0564 NC_008024.1 549558 550199 R phage protein complement(549558..550199) Streptococcus pyogenes MGAS10750 4068008 YP_602059.1 CDS MGAS10750_Spy0565 NC_008024.1 550292 550498 D phage protein 550292..550498 Streptococcus pyogenes MGAS10750 4068009 YP_602060.1 CDS MGAS10750_Spy0566 NC_008024.1 550504 550785 D phage protein 550504..550785 Streptococcus pyogenes MGAS10750 4068010 YP_602061.1 CDS MGAS10750_Spy0567 NC_008024.1 551116 551346 R hypothetical protein complement(551116..551346) Streptococcus pyogenes MGAS10750 4068011 YP_602062.1 CDS MGAS10750_Spy0568 NC_008024.1 551470 551676 D phage protein 551470..551676 Streptococcus pyogenes MGAS10750 4068012 YP_602063.1 CDS MGAS10750_Spy0569 NC_008024.1 551749 551994 D hypothetical protein 551749..551994 Streptococcus pyogenes MGAS10750 4068013 YP_602064.1 CDS MGAS10750_Spy0570 NC_008024.1 551991 552131 D phage protein 551991..552131 Streptococcus pyogenes MGAS10750 4068014 YP_602065.1 CDS MGAS10750_Spy0571 NC_008024.1 552141 552353 D phage protein 552141..552353 Streptococcus pyogenes MGAS10750 4068015 YP_602066.1 CDS MGAS10750_Spy0572 NC_008024.1 552341 552523 D hypothetical protein 552341..552523 Streptococcus pyogenes MGAS10750 4068016 YP_602067.1 CDS MGAS10750_Spy0573 NC_008024.1 552633 552944 D phage protein 552633..552944 Streptococcus pyogenes MGAS10750 4068017 YP_602068.1 CDS MGAS10750_Spy0574 NC_008024.1 552931 553623 D phage protein 552931..553623 Streptococcus pyogenes MGAS10750 4068018 YP_602069.1 CDS MGAS10750_Spy0575 NC_008024.1 553719 554954 D DEAD/DEAH box family; phage DNA/RNA helicase 553719..554954 Streptococcus pyogenes MGAS10750 4068019 YP_602070.1 CDS MGAS10750_Spy0576 NC_008024.1 554970 555428 D phage protein 554970..555428 Streptococcus pyogenes MGAS10750 4067981 YP_602071.1 CDS MGAS10750_Spy0577 NC_008024.1 555431 556243 D phage protein 555431..556243 Streptococcus pyogenes MGAS10750 4067982 YP_602072.1 CDS MGAS10750_Spy0578 NC_008024.1 556233 557708 D DNA primase 556233..557708 Streptococcus pyogenes MGAS10750 4067983 YP_602073.1 CDS MGAS10750_Spy0579 NC_008024.1 557970 558383 D phage protein 557970..558383 Streptococcus pyogenes MGAS10750 4067984 YP_602074.1 CDS MGAS10750_Spy0580 NC_008024.1 558380 558700 D phage protein 558380..558700 Streptococcus pyogenes MGAS10750 4067985 YP_602075.1 CDS MGAS10750_Spy0581 NC_008024.1 558684 559040 D phage protein 558684..559040 Streptococcus pyogenes MGAS10750 4067986 YP_602076.1 CDS MGAS10750_Spy0582 NC_008024.1 559165 559446 D phage protein 559165..559446 Streptococcus pyogenes MGAS10750 4067987 YP_602077.1 CDS MGAS10750_Spy0583 NC_008024.1 559439 559624 D phage protein 559439..559624 Streptococcus pyogenes MGAS10750 4067988 YP_602078.1 CDS MGAS10750_Spy0584 NC_008024.1 559621 559890 D phage protein 559621..559890 Streptococcus pyogenes MGAS10750 4067989 YP_602079.1 CDS MGAS10750_Spy0585 NC_008024.1 559900 560313 D phage protein 559900..560313 Streptococcus pyogenes MGAS10750 4067990 YP_602080.1 CDS MGAS10750_Spy0586 NC_008024.1 560310 560594 D phage protein 560310..560594 Streptococcus pyogenes MGAS10750 4067991 YP_602081.1 CDS MGAS10750_Spy0587 NC_008024.1 560598 561080 D Methyltransferase 560598..561080 Streptococcus pyogenes MGAS10750 4067992 YP_602082.1 CDS MGAS10750_Spy0588 NC_008024.1 561046 561834 D Adenine-specific methyltransferase 561046..561834 Streptococcus pyogenes MGAS10750 4067993 YP_602083.1 CDS MGAS10750_Spy0589 NC_008024.1 561882 562607 D phage protein 561882..562607 Streptococcus pyogenes MGAS10750 4067994 YP_602084.1 CDS MGAS10750_Spy0590 NC_008024.1 563050 563487 D phage protein 563050..563487 Streptococcus pyogenes MGAS10750 4067995 YP_602085.1 CDS MGAS10750_Spy0591 NC_008024.1 563827 564003 R phage protein complement(563827..564003) Streptococcus pyogenes MGAS10750 4067996 YP_602086.1 CDS MGAS10750_Spy0592 NC_008024.1 564043 565035 D phage protein 564043..565035 Streptococcus pyogenes MGAS10750 4067997 YP_602087.1 CDS MGAS10750_Spy0593 NC_008024.1 565162 565578 R phage protein complement(565162..565578) Streptococcus pyogenes MGAS10750 4067998 YP_602088.1 CDS MGAS10750_Spy0594 NC_008024.1 565591 565857 R phage protein complement(565591..565857) Streptococcus pyogenes MGAS10750 4067999 YP_602089.1 CDS MGAS10750_Spy0595 NC_008024.1 566012 566350 D phage endonuclease 566012..566350 Streptococcus pyogenes MGAS10750 4068000 YP_602090.1 CDS MGAS10750_Spy0596 NC_008024.1 566521 566988 D phage terminase small subunit 566521..566988 Streptococcus pyogenes MGAS10750 4067962 YP_602091.1 CDS MGAS10750_Spy0597 NC_008024.1 566991 567221 D hypothetical protein 566991..567221 Streptococcus pyogenes MGAS10750 4067963 YP_602092.1 CDS MGAS10750_Spy0598 NC_008024.1 567222 568979 D Terminase large subunit 567222..568979 Streptococcus pyogenes MGAS10750 4067964 YP_602093.1 CDS MGAS10750_Spy0599 NC_008024.1 568976 569146 D phage protein 568976..569146 Streptococcus pyogenes MGAS10750 4067965 YP_602094.1 CDS MGAS10750_Spy0600 NC_008024.1 569139 569363 D phage protein 569139..569363 Streptococcus pyogenes MGAS10750 4067966 YP_602095.1 CDS MGAS10750_Spy0601 NC_008024.1 569397 570617 D Portal protein 569397..570617 Streptococcus pyogenes MGAS10750 4067967 YP_602096.1 CDS MGAS10750_Spy0602 NC_008024.1 570595 571260 D ATP-dependent endopeptidase clp proteolytic subunit clpP 570595..571260 Streptococcus pyogenes MGAS10750 4067968 YP_602097.1 CDS MGAS10750_Spy0603 NC_008024.1 571273 572472 D phage protein 571273..572472 Streptococcus pyogenes MGAS10750 4067969 YP_602098.1 CDS MGAS10750_Spy0604 NC_008024.1 572486 572614 D phage protein 572486..572614 Streptococcus pyogenes MGAS10750 4067970 YP_602099.1 CDS MGAS10750_Spy0605 NC_008024.1 572617 572919 D phage protein 572617..572919 Streptococcus pyogenes MGAS10750 4067971 YP_602100.1 CDS MGAS10750_Spy0606 NC_008024.1 572916 573263 D phage protein 572916..573263 Streptococcus pyogenes MGAS10750 4067972 YP_602101.1 CDS MGAS10750_Spy0607 NC_008024.1 573260 573637 D phage protein 573260..573637 Streptococcus pyogenes MGAS10750 4067973 YP_602102.1 CDS MGAS10750_Spy0608 NC_008024.1 573634 574059 D phage protein 573634..574059 Streptococcus pyogenes MGAS10750 4067974 YP_602103.1 CDS MGAS10750_Spy0609 NC_008024.1 574075 574683 D Major tail protein 574075..574683 Streptococcus pyogenes MGAS10750 4067975 YP_602104.1 CDS MGAS10750_Spy0610 NC_008024.1 574736 575062 D phage protein 574736..575062 Streptococcus pyogenes MGAS10750 4067976 YP_602105.1 CDS MGAS10750_Spy0611 NC_008024.1 575092 575259 D phage protein 575092..575259 Streptococcus pyogenes MGAS10750 4067977 YP_602106.1 CDS MGAS10750_Spy0612 NC_008024.1 575272 579195 D phage protein 575272..579195 Streptococcus pyogenes MGAS10750 4067978 YP_602107.1 CDS MGAS10750_Spy0613 NC_008024.1 579195 579902 D phage protein 579195..579902 Streptococcus pyogenes MGAS10750 4067979 YP_602108.1 CDS MGAS10750_Spy0614 NC_008024.1 579899 582043 D phage endopeptidase 579899..582043 Streptococcus pyogenes MGAS10750 4067980 YP_602109.1 CDS MGAS10750_Spy0615 NC_008024.1 582040 583050 D Hyaluronoglucosaminidase 582040..583050 Streptococcus pyogenes MGAS10750 4067942 YP_602110.1 CDS MGAS10750_Spy0616 NC_008024.1 583063 584949 D phage infection protein 583063..584949 Streptococcus pyogenes MGAS10750 4067943 YP_602111.1 CDS MGAS10750_Spy0617 NC_008024.1 584961 585392 D phage protein 584961..585392 Streptococcus pyogenes MGAS10750 4067944 YP_602112.1 CDS MGAS10750_Spy0618 NC_008024.1 585395 586012 D phage protein 585395..586012 Streptococcus pyogenes MGAS10750 4067945 YP_602113.1 CDS MGAS10750_Spy0619 NC_008024.1 586022 586522 D phage protein 586022..586522 Streptococcus pyogenes MGAS10750 4067946 YP_602114.1 CDS MGAS10750_Spy0620 NC_008024.1 586638 587843 D phage-associated cell wall hydrolase 586638..587843 Streptococcus pyogenes MGAS10750 4067947 YP_602115.1 CDS speJ NC_008024.1 587911 588618 R Enterotoxin complement(587911..588618) Streptococcus pyogenes MGAS10750 4067948 YP_602116.1 CDS MGAS10750_Spy0622 NC_008024.1 588729 589487 R Streptodornase complement(588729..589487) Streptococcus pyogenes MGAS10750 4067949 YP_602117.1 CDS pepD NC_008024.1 589799 591217 D Dipeptidase A 589799..591217 Streptococcus pyogenes MGAS10750 4067950 YP_602118.1 CDS MGAS10750_Spy0624 NC_008024.1 591369 592916 D High-affinity zinc uptake system protein znuA precursor / hypothetical exported protein 591369..592916 Streptococcus pyogenes MGAS10750 4067951 YP_602119.1 CDS MGAS10750_Spy0625 NC_008024.1 592933 593754 R transposase complement(592933..593754) Streptococcus pyogenes MGAS10750 4067952 YP_602120.1 CDS MGAS10750_Spy0626 NC_008024.1 593732 594391 R transposase complement(593732..594391) Streptococcus pyogenes MGAS10750 4067953 YP_602121.1 CDS MGAS10750_Spy0627 NC_008024.1 594625 595356 D GntR family transcriptional regulator 594625..595356 Streptococcus pyogenes MGAS10750 4067954 YP_602122.1 CDS agaS NC_008024.1 595376 596575 D Galactosamine-6-phosphate deaminase (isomerizing) 595376..596575 Streptococcus pyogenes MGAS10750 4067955 YP_602123.1 CDS rpmE2 NC_008024.1 596673 596933 R RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 type B complement(596673..596933) Streptococcus pyogenes MGAS10750 4067956 YP_602124.1 CDS MGAS10750_Spy0630 NC_008024.1 597048 597989 R phosphoesterase, DHH family protein complement(597048..597989) Streptococcus pyogenes MGAS10750 4067957 YP_602125.1 CDS MGAS10750_Spy0631 NC_008024.1 598383 598832 D An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 598383..598832 Streptococcus pyogenes MGAS10750 4067958 YP_602126.1 CDS MGAS10750_Spy0632 NC_008024.1 599008 599292 D hypothetical protein 599008..599292 Streptococcus pyogenes MGAS10750 4067959 YP_602127.1 CDS MGAS10750_Spy0633 NC_008024.1 599273 600547 D chloride channel protein 599273..600547 Streptococcus pyogenes MGAS10750 4067960 YP_602128.1 CDS rplS NC_008024.1 600662 601009 D this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 600662..601009 Streptococcus pyogenes MGAS10750 4067961 YP_602129.1 CDS MGAS10750_Spy0635 NC_008024.1 602037 602606 D DNA gyrase subunit B 602037..602606 Streptococcus pyogenes MGAS10750 4067925 YP_602130.1 CDS gyrB NC_008024.1 602607 604559 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 602607..604559 Streptococcus pyogenes MGAS10750 4067926 YP_602131.1 CDS MGAS10750_Spy0637 NC_008024.1 604927 606651 D acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation; septation ring formation regulator EzrA 604927..606651 Streptococcus pyogenes MGAS10750 4067927 YP_602132.1 CDS MGAS10750_Spy0638 NC_008024.1 606783 607241 R hypothetical protein complement(606783..607241) Streptococcus pyogenes MGAS10750 4067928 YP_602133.1 CDS eno NC_008024.1 607468 608775 D enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 607468..608775 Streptococcus pyogenes MGAS10750 4067929 YP_602134.1 CDS MGAS10750_Spy0640 NC_008024.1 609364 609885 R transposase complement(609364..609885) Streptococcus pyogenes MGAS10750 4067930 YP_602135.1 CDS MGAS10750_Spy0641 NC_008024.1 609934 610185 R transposase complement(609934..610185) Streptococcus pyogenes MGAS10750 4067931 YP_602136.1 CDS MGAS10750_Spy0642 NC_008024.1 610547 612031 R transcriptional regulator complement(610547..612031) Streptococcus pyogenes MGAS10750 4067932 YP_602137.1 CDS epf NC_008024.1 612561 616682 D Extracellular matrix binding protein 612561..616682 Streptococcus pyogenes MGAS10750 4067933 YP_602138.1 CDS sagA NC_008024.1 617547 617708 D streptolysin S precursor 617547..617708 Streptococcus pyogenes MGAS10750 4067934 YP_602139.1 CDS sagB NC_008024.1 617930 618880 D streptolysin S biosynthesis protein SagB 617930..618880 Streptococcus pyogenes MGAS10750 4067935 YP_602140.1 CDS sagC NC_008024.1 618877 619935 D streptolysin S biosynthesis protein SagC 618877..619935 Streptococcus pyogenes MGAS10750 4067936 YP_602141.1 CDS sagD NC_008024.1 619955 621313 D streptolysin S biosynthesis protein SagD 619955..621313 Streptococcus pyogenes MGAS10750 4067937 YP_602142.1 CDS sagE NC_008024.1 621288 621959 D streptolysin S self-immunity protein SagE 621288..621959 Streptococcus pyogenes MGAS10750 4067938 YP_602143.1 CDS sagF NC_008024.1 621956 622639 D streptolysin S biosynthesis protein SagF 621956..622639 Streptococcus pyogenes MGAS10750 4067939 YP_602144.1 CDS sagG NC_008024.1 622662 623585 D streptolysin S export ATP-binding protein SagG 622662..623585 Streptococcus pyogenes MGAS10750 4067940 YP_602145.1 CDS sagH NC_008024.1 623594 624721 D streptolysin S export transmembrane protein SagH 623594..624721 Streptococcus pyogenes MGAS10750 4067941 YP_602146.1 CDS sagI NC_008024.1 624718 625836 D streptolysin S export transmembrane protein SagI 624718..625836 Streptococcus pyogenes MGAS10750 4067904 YP_602147.1 CDS MGAS10750_Spy0653 NC_008024.1 626409 629141 D endonuclease/exonuclease/phosphatase family protein 626409..629141 Streptococcus pyogenes MGAS10750 4067905 YP_602148.1 CDS MGAS10750_Spy0654 NC_008024.1 629419 629919 D hypothetical protein 629419..629919 Streptococcus pyogenes MGAS10750 4067906 YP_602149.1 CDS ligA NC_008024.1 630112 632070 D this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 630112..632070 Streptococcus pyogenes MGAS10750 4067907 YP_602150.1 CDS MGAS10750_Spy0656 NC_008024.1 632084 633106 D similar to YegS from E. coli; lipid kinase 632084..633106 Streptococcus pyogenes MGAS10750 4067908 YP_602151.1 CDS MGAS10750_Spy0657 NC_008024.1 633498 633710 D transposase 633498..633710 Streptococcus pyogenes MGAS10750 4067909 YP_602152.1 CDS MGAS10750_Spy0658 NC_008024.1 633721 634224 D transposase 633721..634224 Streptococcus pyogenes MGAS10750 4067910 YP_602153.1 CDS atpE NC_008024.1 634291 634488 D produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 634291..634488 Streptococcus pyogenes MGAS10750 4067911 YP_602154.1 CDS atpB NC_008024.1 634523 635239 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 634523..635239 Streptococcus pyogenes MGAS10750 4067912 YP_602155.1 CDS atpF NC_008024.1 635257 635751 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 635257..635751 Streptococcus pyogenes MGAS10750 4067913 YP_602156.1 CDS atpH NC_008024.1 635751 636287 D Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 635751..636287 Streptococcus pyogenes MGAS10750 4067914 YP_602157.1 CDS atpA NC_008024.1 636303 637811 D produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 636303..637811 Streptococcus pyogenes MGAS10750 4067915 YP_602158.1 CDS atpG NC_008024.1 637827 638702 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 637827..638702 Streptococcus pyogenes MGAS10750 4067916 YP_602159.1 CDS atpD NC_008024.1 638864 640270 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 638864..640270 Streptococcus pyogenes MGAS10750 4067917 YP_602160.1 CDS atpC NC_008024.1 640283 640699 D part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 640283..640699 Streptococcus pyogenes MGAS10750 4067918 YP_602161.1 CDS MGAS10750_Spy0667 NC_008024.1 640965 641222 D hypothetical protein 640965..641222 Streptococcus pyogenes MGAS10750 4067919 YP_602162.1 CDS murA NC_008024.1 641287 642558 D adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 641287..642558 Streptococcus pyogenes MGAS10750 4067920 YP_602163.1 CDS epuA NC_008024.1 642562 642750 D EpuA protein 642562..642750 Streptococcus pyogenes MGAS10750 4067921 YP_602164.1 CDS MGAS10750_Spy0670 NC_008024.1 642774 643364 D DNA-entry nuclease 642774..643364 Streptococcus pyogenes MGAS10750 4067922 YP_602165.1 CDS endA NC_008024.1 643348 643650 D DNA-entry nuclease 643348..643650 Streptococcus pyogenes MGAS10750 4067923 YP_602166.2 CDS pheS NC_008024.1 643933 644976 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 643933..644976 Streptococcus pyogenes MGAS10750 4067885 YP_602167.1 CDS pheT NC_008024.1 645171 647591 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 645171..647591 Streptococcus pyogenes MGAS10750 4067886 YP_602168.1 CDS MGAS10750_Spy0674 NC_008024.1 647665 648078 D Salt-stress induced protein 647665..648078 Streptococcus pyogenes MGAS10750 4067887 YP_602169.1 CDS MGAS10750_Spy0675 NC_008024.1 648071 648457 D hypothetical protein 648071..648457 Streptococcus pyogenes MGAS10750 4067888 YP_602170.1 CDS MGAS10750_Spy0676 NC_008024.1 648530 649606 D ABC transporter permease 648530..649606 Streptococcus pyogenes MGAS10750 4067889 YP_602171.1 CDS MGAS10750_Spy0677 NC_008024.1 649613 650284 D ABC transporter ATP-binding protein 649613..650284 Streptococcus pyogenes MGAS10750 4067890 YP_602172.1 CDS MGAS10750_Spy0678 NC_008024.1 650386 651303 R Neutral zinc metallopeptidase family complement(650386..651303) Streptococcus pyogenes MGAS10750 4067891 YP_602173.1 CDS rexB NC_008024.1 651454 654669 D ATP-dependent nuclease subunit B 651454..654669 Streptococcus pyogenes MGAS10750 4067892 YP_602174.1 CDS rexA NC_008024.1 654630 658298 D ATP-dependent nuclease subunit A 654630..658298 Streptococcus pyogenes MGAS10750 4067893 YP_602175.1 CDS MGAS10750_Spy0681 NC_008024.1 658438 659250 D arginine-binding protein 658438..659250 Streptococcus pyogenes MGAS10750 4067894 YP_602176.2 CDS rpsU NC_008024.1 659391 659567 D a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 659391..659567 Streptococcus pyogenes MGAS10750 4067895 YP_602177.1 CDS mscL NC_008024.1 659695 660057 R Large-conductance mechanosensitive channel complement(659695..660057) Streptococcus pyogenes MGAS10750 4067896 YP_602178.1 CDS MGAS10750_Spy0684 NC_008024.1 660220 661362 D transposase 660220..661362 Streptococcus pyogenes MGAS10750 4067897 YP_602179.1 CDS MGAS10750_Spy0685 NC_008024.1 661346 661450 D hypothetical protein 661346..661450 Streptococcus pyogenes MGAS10750 4067898 YP_602180.1 CDS dnaG NC_008024.1 661447 663327 D synthesizes RNA primers at the replication forks; DNA primase 661447..663327 Streptococcus pyogenes MGAS10750 4067899 YP_602181.1 CDS rpoD NC_008024.1 663336 664445 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium; RNA polymerase sigma factor RpoD 663336..664445 Streptococcus pyogenes MGAS10750 4067900 YP_602182.1 CDS MGAS10750_Spy0688 NC_008024.1 664681 665019 D hypothetical protein 664681..665019 Streptococcus pyogenes MGAS10750 4067901 YP_602183.1 CDS rmlD NC_008024.1 665097 666011 D dTDP-4-dehydrorhamnose reductase 665097..666011 Streptococcus pyogenes MGAS10750 4067902 YP_602184.1 CDS rgpAc NC_008024.1 666130 667284 D alpha-D-GlcNAc alpha-1,2-L-rhamnosyltransferase 666130..667284 Streptococcus pyogenes MGAS10750 4067903 YP_602185.1 CDS rgpBc NC_008024.1 667274 668206 D alpha-L-Rha alpha-1,3-L-rhamnosyltransferase 667274..668206 Streptococcus pyogenes MGAS10750 4067865 YP_602186.1 CDS rgpCc NC_008024.1 668209 669012 D Polysaccharide export ABC transporter permease 668209..669012 Streptococcus pyogenes MGAS10750 4067866 YP_602187.1 CDS rgpDc NC_008024.1 669012 670217 D Polysaccharide export ATP-binding protein 669012..670217 Streptococcus pyogenes MGAS10750 4067867 YP_602188.1 CDS rgpEc NC_008024.1 670242 671249 D glycosyltransferase 670242..671249 Streptococcus pyogenes MGAS10750 4067868 YP_602189.1 CDS rgpFc NC_008024.1 671246 672991 D bifunctional; alpha-L-Rha alpha-1,2-L-rhamnosyltransferase / alpha-L-Rha alpha-1,3-L-rhamnosyltransferase 671246..672991 Streptococcus pyogenes MGAS10750 4067869 YP_602190.1 CDS MGAS10750_Spy0696 NC_008024.1 672988 675462 D phosphoglycerol transferase 672988..675462 Streptococcus pyogenes MGAS10750 4067870 YP_602191.1 CDS MGAS10750_Spy0697 NC_008024.1 675641 676336 D cell wall biogenesis glycosyltransferase 675641..676336 Streptococcus pyogenes MGAS10750 4067871 YP_602192.1 CDS MGAS10750_Spy0698 NC_008024.1 676338 676679 D hypothetical protein 676338..676679 Streptococcus pyogenes MGAS10750 4067872 YP_602193.1 CDS amrA NC_008024.1 676672 677958 D transcriptional activator amrA 676672..677958 Streptococcus pyogenes MGAS10750 4067873 YP_602194.1 CDS MGAS10750_Spy0700 NC_008024.1 677939 679435 D hypothetical protein 677939..679435 Streptococcus pyogenes MGAS10750 4067874 YP_602195.1 CDS pepT NC_008024.1 679517 680752 D catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 679517..680752 Streptococcus pyogenes MGAS10750 4067875 YP_602196.1 CDS ebsA NC_008024.1 680793 681281 D Pore forming protein ebsA 680793..681281 Streptococcus pyogenes MGAS10750 4067876 YP_602197.1 CDS MGAS10750_Spy0703 NC_008024.1 681268 681465 R Ferredoxin complement(681268..681465) Streptococcus pyogenes MGAS10750 4067877 YP_602198.1 CDS MGAS10750_Spy0704 NC_008024.1 681513 681989 D hypothetical protein 681513..681989 Streptococcus pyogenes MGAS10750 4067878 YP_602199.1 CDS cmk NC_008024.1 682004 682684 D Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 682004..682684 Streptococcus pyogenes MGAS10750 4067879 YP_602200.1 CDS infC NC_008024.1 682846 683376 D IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 682846..683376 Streptococcus pyogenes MGAS10750 4067880 YP_602201.1 CDS rpmI NC_008024.1 683418 683615 D 50S ribosomal protein L35 683418..683615 Streptococcus pyogenes MGAS10750 4067881 YP_602202.1 CDS rplT NC_008024.1 683674 684033 D binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 683674..684033 Streptococcus pyogenes MGAS10750 4067882 YP_602203.1 CDS MGAS10750_Spy0709 NC_008024.1 684324 686540 R sulfatase complement(684324..686540) Streptococcus pyogenes MGAS10750 4067883 YP_602204.1 CDS MGAS10750_Spy0710 NC_008024.1 686642 687805 D Methyltransferase 686642..687805 Streptococcus pyogenes MGAS10750 4067884 YP_602205.1 CDS aroD NC_008024.1 687802 688488 D catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 687802..688488 Streptococcus pyogenes MGAS10750 4067846 YP_602206.1 CDS aroF NC_008024.1 688582 689748 D catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 688582..689748 Streptococcus pyogenes MGAS10750 4067847 YP_602207.1 CDS MGAS10750_Spy0713 NC_008024.1 689809 690150 D hypothetical protein 689809..690150 Streptococcus pyogenes MGAS10750 4067848 YP_602208.1 CDS MGAS10750_Spy0714 NC_008024.1 690139 690279 R hypothetical protein complement(690139..690279) Streptococcus pyogenes MGAS10750 4067849 YP_602209.1 CDS gor NC_008024.1 690372 691724 D catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 690372..691724 Streptococcus pyogenes MGAS10750 4067850 YP_602210.1 CDS folC2 NC_008024.1 691812 693104 R bifunctional; Folylpolyglutamate synthase / dihydrofolate synthase complement(691812..693104) Streptococcus pyogenes MGAS10750 4067851 YP_602211.1 CDS MGAS10750_Spy0717 NC_008024.1 693110 693571 R hypothetical protein complement(693110..693571) Streptococcus pyogenes MGAS10750 4067852 YP_602212.1 CDS nifS1 NC_008024.1 693785 694906 D bifunctional; cysteine desulfurase / Selenocysteine lyase 693785..694906 Streptococcus pyogenes MGAS10750 4067853 YP_602213.1 CDS thiI NC_008024.1 694940 696154 D Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 694940..696154 Streptococcus pyogenes MGAS10750 4067854 YP_602214.1 CDS capA NC_008024.1 696192 697484 D Capsule biosynthesis protein capA 696192..697484 Streptococcus pyogenes MGAS10750 4067855 YP_602215.1 CDS MGAS10750_Spy0721 NC_008024.1 697503 698456 R transposase complement(697503..698456) Streptococcus pyogenes MGAS10750 4067856 YP_602216.1 CDS rplU NC_008024.1 698731 699045 D 50S ribosomal protein L21 698731..699045 Streptococcus pyogenes MGAS10750 4067857 YP_602217.1 CDS MGAS10750_Spy0723 NC_008024.1 699057 699383 D hypothetical protein 699057..699383 Streptococcus pyogenes MGAS10750 4067858 YP_602218.1 CDS rpmA NC_008024.1 699411 699704 D involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 699411..699704 Streptococcus pyogenes MGAS10750 4067859 YP_602219.1 CDS MGAS10750_Spy0725 NC_008024.1 700062 700976 D LysR family transcriptional regulator 700062..700976 Streptococcus pyogenes MGAS10750 4067860 YP_602220.1 CDS lsp NC_008024.1 700973 701431 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 700973..701431 Streptococcus pyogenes MGAS10750 4067861 YP_602221.1 CDS MGAS10750_Spy0727 NC_008024.1 701421 702311 D ribosomal large subunit pseudouridine synthase D 701421..702311 Streptococcus pyogenes MGAS10750 4067862 YP_602222.1 CDS pyrR NC_008024.1 702706 703227 D regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase 702706..703227 Streptococcus pyogenes MGAS10750 4067863 YP_602223.1 CDS pyrP NC_008024.1 703243 704502 D uracil permease 703243..704502 Streptococcus pyogenes MGAS10750 4067864 YP_602224.1 CDS pyrB NC_008024.1 704509 705498 D catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit 704509..705498 Streptococcus pyogenes MGAS10750 4067826 YP_602225.1 CDS carA NC_008024.1 705542 706624 D catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 705542..706624 Streptococcus pyogenes MGAS10750 4067827 YP_602226.1 CDS MGAS10750_Spy0732 NC_008024.1 706596 706793 D hypothetical protein 706596..706793 Streptococcus pyogenes MGAS10750 4067828 YP_602227.2 CDS carB NC_008024.1 706870 710046 D four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 706870..710046 Streptococcus pyogenes MGAS10750 4067829 YP_602228.1 CDS MGAS10750_Spy0734 NC_008024.1 710251 711522 D periplasmic component of efflux system 710251..711522 Streptococcus pyogenes MGAS10750 4067830 YP_602229.1 CDS MGAS10750_Spy0735 NC_008024.1 711522 712232 D ABC transporter ATP-binding protein 711522..712232 Streptococcus pyogenes MGAS10750 4067831 YP_602230.1 CDS MGAS10750_Spy0736 NC_008024.1 712244 713464 D ABC transporter permease 712244..713464 Streptococcus pyogenes MGAS10750 4067832 YP_602231.1 CDS MGAS10750_Spy0737 NC_008024.1 713676 715451 D glycerophosphodiester phosphodiesterase 713676..715451 Streptococcus pyogenes MGAS10750 4067833 YP_602232.1 CDS rpsP NC_008024.1 715578 715850 D binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 715578..715850 Streptococcus pyogenes MGAS10750 4067834 YP_602233.1 CDS MGAS10750_Spy0739 NC_008024.1 715860 716099 D RNA binding protein 715860..716099 Streptococcus pyogenes MGAS10750 4067835 YP_602234.1 CDS MGAS10750_Spy0740 NC_008024.1 716248 716907 D transposase 716248..716907 Streptococcus pyogenes MGAS10750 4067836 YP_602235.1 CDS MGAS10750_Spy0741 NC_008024.1 716885 717697 D transposase 716885..717697 Streptococcus pyogenes MGAS10750 4067837 YP_602236.1 CDS MGAS10750_Spy0742 NC_008024.1 718596 721637 D cell surface protein 718596..721637 Streptococcus pyogenes MGAS10750 4067838 YP_602237.1 CDS MGAS10750_Spy0743 NC_008024.1 721657 722058 D hypothetical protein 721657..722058 Streptococcus pyogenes MGAS10750 4067839 YP_602238.1 CDS czcD NC_008024.1 722238 723113 R Cobalt-zinc-cadmium resistance protein czcD complement(722238..723113) Streptococcus pyogenes MGAS10750 4067840 YP_602239.1 CDS MGAS10750_Spy0745 NC_008024.1 723240 723770 D TetR family transcriptional regulator 723240..723770 Streptococcus pyogenes MGAS10750 4067841 YP_602240.1 CDS rimM NC_008024.1 723985 724503 D Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 723985..724503 Streptococcus pyogenes MGAS10750 4067842 YP_602241.1 CDS trmD NC_008024.1 724493 725212 D methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 724493..725212 Streptococcus pyogenes MGAS10750 4067843 YP_602242.1 CDS trxB NC_008024.1 725224 726216 D Thioredoxin reductase 725224..726216 Streptococcus pyogenes MGAS10750 4067844 YP_602243.1 CDS MGAS10750_Spy0749 NC_008024.1 726394 727452 D hypothetical protein 726394..727452 Streptococcus pyogenes MGAS10750 4067845 YP_602244.1 CDS apbA NC_008024.1 727465 728388 D ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 727465..728388 Streptococcus pyogenes MGAS10750 4067807 YP_602245.1 CDS fruR NC_008024.1 728644 729357 D Fructose repressor 728644..729357 Streptococcus pyogenes MGAS10750 4067808 YP_602246.1 CDS fruB NC_008024.1 729354 730265 D 1-phosphofructokinase 729354..730265 Streptococcus pyogenes MGAS10750 4067809 YP_602247.1 CDS fruA NC_008024.1 730262 732208 D PTS system, fructose-specific IIABC component 730262..732208 Streptococcus pyogenes MGAS10750 4067810 YP_602248.1 CDS mur1-1 NC_008024.1 732307 732900 D N-acetylmuramidase 732307..732900 Streptococcus pyogenes MGAS10750 4067811 YP_602249.1 CDS mur1-2 NC_008024.1 733052 733759 D N-acetylmuramidase 733052..733759 Streptococcus pyogenes MGAS10750 4067812 YP_602250.1 CDS MGAS10750_Spy0756 NC_008024.1 733816 734034 R transposase complement(733816..734034) Streptococcus pyogenes MGAS10750 4067813 YP_602251.1 CDS MGAS10750_Spy0757 NC_008024.1 734237 734356 R hypothetical protein complement(734237..734356) Streptococcus pyogenes MGAS10750 4067814 YP_602252.1 CDS MGAS10750_Spy0758 NC_008024.1 734331 734540 R exotoxin type C precursor complement(734331..734540) Streptococcus pyogenes MGAS10750 4067815 YP_602253.1 CDS mac NC_008024.1 734791 735735 R hypothetical protein complement(734791..735735) Streptococcus pyogenes MGAS10750 4067816 YP_602254.1 CDS MGAS10750_Spy0760 NC_008024.1 735890 736009 D phage protein 735890..736009 Streptococcus pyogenes MGAS10750 4067817 YP_602255.1 CDS MGAS10750_Spy0761 NC_008024.1 736234 736410 D nucleoside diphosphate kinase 736234..736410 Streptococcus pyogenes MGAS10750 4067818 YP_602256.1 CDS MGAS10750_Spy0762 NC_008024.1 736638 737018 D hypothetical protein 736638..737018 Streptococcus pyogenes MGAS10750 4067819 YP_602257.1 CDS MGAS10750_Spy0763 NC_008024.1 737018 737866 D DegV family protein 737018..737866 Streptococcus pyogenes MGAS10750 4067820 YP_602258.1 CDS papS NC_008024.1 737991 739199 D catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase 737991..739199 Streptococcus pyogenes MGAS10750 4067821 YP_602259.1 CDS MGAS10750_Spy0765 NC_008024.1 739196 741073 D ABC transporter ATP-binding protein 739196..741073 Streptococcus pyogenes MGAS10750 4067822 YP_602260.1 CDS MGAS10750_Spy0766 NC_008024.1 741330 741482 D hypothetical protein 741330..741482 Streptococcus pyogenes MGAS10750 4067823 YP_602261.1 CDS MGAS10750_Spy0767 NC_008024.1 741472 741597 D hypothetical protein 741472..741597 Streptococcus pyogenes MGAS10750 4067824 YP_602262.1 CDS MGAS10750_Spy0768 NC_008024.1 741491 741709 D hypothetical protein 741491..741709 Streptococcus pyogenes MGAS10750 4067825 YP_602263.1 CDS fms NC_008024.1 741963 742373 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 741963..742373 Streptococcus pyogenes MGAS10750 4067787 YP_602264.1 CDS MGAS10750_Spy0770 NC_008024.1 742455 744440 R 5'-nucleotidase complement(742455..744440) Streptococcus pyogenes MGAS10750 4067788 YP_602265.1 CDS MGAS10750_Spy0771 NC_008024.1 744692 745342 D GTP pyrophosphokinase 744692..745342 Streptococcus pyogenes MGAS10750 4067789 YP_602266.1 CDS sptR NC_008024.1 745345 746013 D two-component response regulator 745345..746013 Streptococcus pyogenes MGAS10750 4067790 YP_602267.1 CDS sptS NC_008024.1 745995 747254 D two-component system histidine kinase 745995..747254 Streptococcus pyogenes MGAS10750 4067791 YP_602268.1 CDS mvaK1 NC_008024.1 747548 748426 D Mevalonate kinase 747548..748426 Streptococcus pyogenes MGAS10750 4067792 YP_602269.1 CDS mvaD NC_008024.1 748408 749352 D Diphosphomevalonate decarboxylase 748408..749352 Streptococcus pyogenes MGAS10750 4067793 YP_602270.1 CDS mvaK2 NC_008024.1 749297 750352 D phosphomevalonate kinase 749297..750352 Streptococcus pyogenes MGAS10750 4067794 YP_602271.1 CDS MGAS10750_Spy0777 NC_008024.1 750255 751334 D catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase 750255..751334 Streptococcus pyogenes MGAS10750 4067795 YP_602272.1 CDS MGAS10750_Spy0778 NC_008024.1 751564 752841 R bifunctional; 3-hydroxy-3-methylglutaryl-coenzyme A reductase / 3-hydroxy-3-methylglutaryl-coenzyme A reductase complement(751564..752841) Streptococcus pyogenes MGAS10750 4067796 YP_602273.1 CDS mvaS1 NC_008024.1 752828 754042 R hydroxymethylglutaryl-CoA synthase complement(752828..754042) Streptococcus pyogenes MGAS10750 4067797 YP_602274.1 CDS thyA NC_008024.1 754188 755051 D ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 754188..755051 Streptococcus pyogenes MGAS10750 4067798 YP_602275.1 CDS dyr NC_008024.1 755131 755628 D dihydrofolate reductase 755131..755628 Streptococcus pyogenes MGAS10750 4067799 YP_602276.1 CDS MGAS10750_Spy0782 NC_008024.1 755648 755818 D hypothetical protein 755648..755818 Streptococcus pyogenes MGAS10750 4067800 YP_602277.1 CDS clpX NC_008024.1 755948 757177 D binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 755948..757177 Streptococcus pyogenes MGAS10750 4067801 YP_602278.1 CDS engB NC_008024.1 757187 757786 D binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 757187..757786 Streptococcus pyogenes MGAS10750 4067802 YP_602279.1 CDS MGAS10750_Spy0785 NC_008024.1 757934 758677 D hypothetical protein 757934..758677 Streptococcus pyogenes MGAS10750 4067803 YP_602280.1 CDS clpL NC_008024.1 758735 760834 R ATP-dependent endopeptidase clp ATP-binding subunit clpL complement(758735..760834) Streptococcus pyogenes MGAS10750 4067804 YP_602281.1 CDS rpiA NC_008024.1 761211 761894 D Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 761211..761894 Streptococcus pyogenes MGAS10750 4067805 YP_602282.1 CDS deoB NC_008024.1 761971 763182 D catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 761971..763182 Streptococcus pyogenes MGAS10750 4067806 YP_602283.1 CDS arsC NC_008024.1 763195 763641 D arsenate reductase 763195..763641 Streptococcus pyogenes MGAS10750 4067768 YP_602284.1 CDS punA NC_008024.1 763625 764434 D catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 763625..764434 Streptococcus pyogenes MGAS10750 4067769 YP_602285.1 CDS deoD NC_008024.1 765097 765810 D catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 765097..765810 Streptococcus pyogenes MGAS10750 4067770 YP_602286.1 CDS cpsX NC_008024.1 765797 766591 D histidine protein kinase 765797..766591 Streptococcus pyogenes MGAS10750 4067771 YP_602287.1 CDS cpsY NC_008024.1 766671 767576 R LysR family transcriptional regulator complement(766671..767576) Streptococcus pyogenes MGAS10750 4067772 YP_602288.1 CDS MGAS10750_Spy0794 NC_008024.1 767798 768334 D hypothetical protein 767798..768334 Streptococcus pyogenes MGAS10750 4067773 YP_602289.1 CDS pyrF NC_008024.1 768611 769303 D type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 768611..769303 Streptococcus pyogenes MGAS10750 4067774 YP_602290.1 CDS pyrE NC_008024.1 769361 769990 D involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 769361..769990 Streptococcus pyogenes MGAS10750 4067775 YP_602291.1 CDS amiC NC_008024.1 770187 771641 D catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 770187..771641 Streptococcus pyogenes MGAS10750 4067776 YP_602292.1 CDS MGAS10750_Spy0798 NC_008024.1 771723 772622 D cystine-binding protein 771723..772622 Streptococcus pyogenes MGAS10750 4067777 YP_602293.1 CDS MGAS10750_Spy0799 NC_008024.1 772651 773301 D cystine transport system permease 772651..773301 Streptococcus pyogenes MGAS10750 4067778 YP_602294.1 CDS ung NC_008024.1 773434 774087 D Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 773434..774087 Streptococcus pyogenes MGAS10750 4067779 YP_602295.1 CDS pyrC NC_008024.1 774219 775487 D catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 774219..775487 Streptococcus pyogenes MGAS10750 4067780 YP_602296.1 CDS MGAS10750_Spy0802 NC_008024.1 775545 776267 R involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY complement(775545..776267) Streptococcus pyogenes MGAS10750 4067781 YP_602297.1 CDS parE NC_008024.1 776318 778270 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 776318..778270 Streptococcus pyogenes MGAS10750 4067782 YP_602298.1 CDS parC NC_008024.1 778355 780820 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 778355..780820 Streptococcus pyogenes MGAS10750 4067783 YP_602299.1 CDS bcaT NC_008024.1 780898 781965 D catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 780898..781965 Streptococcus pyogenes MGAS10750 4067784 YP_602300.1 CDS MGAS10750_Spy0806 NC_008024.1 782086 782745 D transposase 782086..782745 Streptococcus pyogenes MGAS10750 4067785 YP_602301.1 CDS MGAS10750_Spy0807 NC_008024.1 782723 783550 D transposase 782723..783550 Streptococcus pyogenes MGAS10750 4067786 YP_602302.1 CDS MGAS10750_Spy0808 NC_008024.1 783584 783814 D hypothetical protein 783584..783814 Streptococcus pyogenes MGAS10750 4067752 YP_602303.1 CDS rpsA NC_008024.1 784203 785408 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 784203..785408 Streptococcus pyogenes MGAS10750 4067755 YP_602304.1 CDS MGAS10750_Spy0810 NC_008024.1 785956 786258 R hypothetical protein complement(785956..786258) Streptococcus pyogenes MGAS10750 4067757 YP_602305.1 CDS MGAS10750_Spy0811 NC_008024.1 786460 787446 D hypothetical protein 786460..787446 Streptococcus pyogenes MGAS10750 4067758 YP_602306.1 CDS MGAS10750_Spy0812 NC_008024.1 787517 787708 D hypothetical protein 787517..787708 Streptococcus pyogenes MGAS10750 4067759 YP_602307.1 CDS MGAS10750_Spy0813 NC_008024.1 787757 788176 D glutathione S-transferase 787757..788176 Streptococcus pyogenes MGAS10750 4067760 YP_602308.1 CDS MGAS10750_Spy0814 NC_008024.1 788371 789321 D transporter 788371..789321 Streptococcus pyogenes MGAS10750 4067761 YP_602309.1 CDS MGAS10750_Spy0815 NC_008024.1 789439 789621 R hypothetical protein complement(789439..789621) Streptococcus pyogenes MGAS10750 4067762 YP_602310.1 CDS miaA NC_008024.1 789749 790648 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 789749..790648 Streptococcus pyogenes MGAS10750 4067763 YP_602311.1 CDS hflX NC_008024.1 790709 791959 D GTP-binding protein hflX 790709..791959 Streptococcus pyogenes MGAS10750 4067764 YP_602312.1 CDS MGAS10750_Spy0818 NC_008024.1 791940 792587 D hypothetical protein 791940..792587 Streptococcus pyogenes MGAS10750 4067765 YP_602313.1 CDS elaC NC_008024.1 792602 793531 D member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 792602..793531 Streptococcus pyogenes MGAS10750 4067766 YP_602314.1 CDS MGAS10750_Spy0820 NC_008024.1 793531 794295 D Short chain dehydrogenase 793531..794295 Streptococcus pyogenes MGAS10750 4067767 YP_602315.1 CDS recJ NC_008024.1 794292 796502 D Single-stranded-DNA-specific exonuclease recJ 794292..796502 Streptococcus pyogenes MGAS10750 4067732 YP_602316.1 CDS apt NC_008024.1 796653 797171 D catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 796653..797171 Streptococcus pyogenes MGAS10750 4067733 YP_602317.1 CDS dnaD NC_008024.1 797252 797935 D DNA replication protein dnaD 797252..797935 Streptococcus pyogenes MGAS10750 4067734 YP_602318.1 CDS nth NC_008024.1 797932 798588 D endonuclease III 797932..798588 Streptococcus pyogenes MGAS10750 4067735 YP_602319.1 CDS MGAS10750_Spy0825 NC_008024.1 798660 799346 D hypothetical protein 798660..799346 Streptococcus pyogenes MGAS10750 4067736 YP_602320.1 CDS MGAS10750_Spy0826 NC_008024.1 799330 800124 D NIF3-related protein 799330..800124 Streptococcus pyogenes MGAS10750 4067737 YP_602321.1 CDS MGAS10750_Spy0827 NC_008024.1 800164 801270 D glycine/D-amino acid oxidases family 800164..801270 Streptococcus pyogenes MGAS10750 4067738 YP_602322.1 CDS cpsFO NC_008024.1 801328 802197 D glucose-1-phosphate thymidylyltransferase 801328..802197 Streptococcus pyogenes MGAS10750 4067739 YP_602323.1 CDS cpsFP NC_008024.1 802197 802790 D dTDP-4-dehydrorhamnose 3,5-epimerase 802197..802790 Streptococcus pyogenes MGAS10750 4067740 YP_602324.1 CDS cpsFQ NC_008024.1 803034 804074 D dTDP-glucose 4,6-dehydratase 803034..804074 Streptococcus pyogenes MGAS10750 4067741 YP_602325.1 CDS MGAS10750_Spy0831 NC_008024.1 804157 805296 R DNA integration/recombination/inversion protein complement(804157..805296) Streptococcus pyogenes MGAS10750 4067742 YP_602326.1 CDS MGAS10750_Spy0832 NC_008024.1 805418 806104 R phage protein complement(805418..806104) Streptococcus pyogenes MGAS10750 4067743 YP_602327.1 CDS MGAS10750_Spy0833 NC_008024.1 806134 806268 R phage protein complement(806134..806268) Streptococcus pyogenes MGAS10750 4067744 YP_602328.1 CDS MGAS10750_Spy0834 NC_008024.1 806275 806427 R phage protein complement(806275..806427) Streptococcus pyogenes MGAS10750 4067745 YP_602329.1 CDS MGAS10750_Spy0835 NC_008024.1 806438 806815 R phage protein complement(806438..806815) Streptococcus pyogenes MGAS10750 4067746 YP_602330.1 CDS MGAS10750_Spy0836 NC_008024.1 806799 807158 R MerR family transcriptional regulator complement(806799..807158) Streptococcus pyogenes MGAS10750 4067747 YP_602331.1 CDS MGAS10750_Spy0837 NC_008024.1 807260 807565 D Cro family transcriptional regulator 807260..807565 Streptococcus pyogenes MGAS10750 4067748 YP_602332.1 CDS MGAS10750_Spy0838 NC_008024.1 807660 807911 D phage protein 807660..807911 Streptococcus pyogenes MGAS10750 4067749 YP_602333.1 CDS MGAS10750_Spy0839 NC_008024.1 807942 808076 D phage protein 807942..808076 Streptococcus pyogenes MGAS10750 4067750 YP_602334.1 CDS MGAS10750_Spy0840 NC_008024.1 808092 808406 D Cro/CI family transcriptional regulator 808092..808406 Streptococcus pyogenes MGAS10750 4067751 YP_602335.1 CDS MGAS10750_Spy0841 NC_008024.1 808633 809115 D phage protein 808633..809115 Streptococcus pyogenes MGAS10750 4067713 YP_602336.1 CDS MGAS10750_Spy0842 NC_008024.1 809116 809796 D phage protein 809116..809796 Streptococcus pyogenes MGAS10750 4067714 YP_602337.1 CDS MGAS10750_Spy0843 NC_008024.1 809898 811127 D DEAD/DEAH box family; phage DNA/RNA helicase 809898..811127 Streptococcus pyogenes MGAS10750 4067715 YP_602338.1 CDS MGAS10750_Spy0844 NC_008024.1 811143 811601 D phage protein 811143..811601 Streptococcus pyogenes MGAS10750 4067716 YP_602339.1 CDS MGAS10750_Spy0845 NC_008024.1 811604 812416 D phage protein 811604..812416 Streptococcus pyogenes MGAS10750 4067717 YP_602340.1 CDS MGAS10750_Spy0846 NC_008024.1 812406 812960 D DNA primase 812406..812960 Streptococcus pyogenes MGAS10750 4067718 YP_602341.1 CDS MGAS10750_Spy0847 NC_008024.1 812966 813886 D DNA primase 812966..813886 Streptococcus pyogenes MGAS10750 4067719 YP_602342.1 CDS MGAS10750_Spy0848 NC_008024.1 814131 814451 D phage protein 814131..814451 Streptococcus pyogenes MGAS10750 4067720 YP_602343.1 CDS MGAS10750_Spy0849 NC_008024.1 814435 814791 D phage protein 814435..814791 Streptococcus pyogenes MGAS10750 4067721 YP_602344.1 CDS MGAS10750_Spy0850 NC_008024.1 814788 815039 D phage protein 814788..815039 Streptococcus pyogenes MGAS10750 4067722 YP_602345.1 CDS MGAS10750_Spy0851 NC_008024.1 815033 815317 D phage protein 815033..815317 Streptococcus pyogenes MGAS10750 4067723 YP_602346.1 CDS MGAS10750_Spy0852 NC_008024.1 815314 815583 D phage protein 815314..815583 Streptococcus pyogenes MGAS10750 4067724 YP_602347.1 CDS MGAS10750_Spy0853 NC_008024.1 815593 815997 D phage protein 815593..815997 Streptococcus pyogenes MGAS10750 4067725 YP_602348.1 CDS MGAS10750_Spy0854 NC_008024.1 815994 816164 D phage protein 815994..816164 Streptococcus pyogenes MGAS10750 4067726 YP_602349.1 CDS MGAS10750_Spy0855 NC_008024.1 816161 816667 D phage protein 816161..816667 Streptococcus pyogenes MGAS10750 4067727 YP_602350.1 CDS MGAS10750_Spy0856 NC_008024.1 817096 817548 D phage encoded transcriptional regulator, ArpU family 817096..817548 Streptococcus pyogenes MGAS10750 4067728 YP_602351.1 CDS MGAS10750_Spy0857 NC_008024.1 817694 817915 D phage protein 817694..817915 Streptococcus pyogenes MGAS10750 4067729 YP_602352.1 CDS MGAS10750_Spy0858 NC_008024.1 817912 818130 R phage protein complement(817912..818130) Streptococcus pyogenes MGAS10750 4067730 YP_602353.1 CDS MGAS10750_Spy0859 NC_008024.1 818217 818597 D phage protein 818217..818597 Streptococcus pyogenes MGAS10750 4067731 YP_602354.1 CDS MGAS10750_Spy0860 NC_008024.1 818563 819861 D Terminase large subunit 818563..819861 Streptococcus pyogenes MGAS10750 4066846 YP_602355.1 CDS MGAS10750_Spy0861 NC_008024.1 819861 821186 D Portal protein 819861..821186 Streptococcus pyogenes MGAS10750 4066847 YP_602356.1 CDS MGAS10750_Spy0862 NC_008024.1 821155 822063 D phage protein 821155..822063 Streptococcus pyogenes MGAS10750 4066848 YP_602357.1 CDS MGAS10750_Spy0863 NC_008024.1 822070 822300 D phage protein 822070..822300 Streptococcus pyogenes MGAS10750 4066849 YP_602358.1 CDS MGAS10750_Spy0864 NC_008024.1 822382 822981 D phage scaffold protein 822382..822981 Streptococcus pyogenes MGAS10750 4066850 YP_602359.1 CDS MGAS10750_Spy0865 NC_008024.1 823000 823890 D phage protein 823000..823890 Streptococcus pyogenes MGAS10750 4066851 YP_602360.1 CDS MGAS10750_Spy0866 NC_008024.1 823902 824195 D phage protein 823902..824195 Streptococcus pyogenes MGAS10750 4066852 YP_602361.1 CDS MGAS10750_Spy0867 NC_008024.1 824209 824553 D phage protein 824209..824553 Streptococcus pyogenes MGAS10750 4066853 YP_602362.1 CDS MGAS10750_Spy0868 NC_008024.1 824550 824861 D phage protein 824550..824861 Streptococcus pyogenes MGAS10750 4066854 YP_602363.1 CDS MGAS10750_Spy0869 NC_008024.1 824858 825253 D antigen C 824858..825253 Streptococcus pyogenes MGAS10750 4066855 YP_602364.1 CDS MGAS10750_Spy0870 NC_008024.1 825255 825665 D antigen B 825255..825665 Streptococcus pyogenes MGAS10750 4066856 YP_602365.1 CDS MGAS10750_Spy0871 NC_008024.1 825680 826183 D antigen A 825680..826183 Streptococcus pyogenes MGAS10750 4066857 YP_602366.1 CDS MGAS10750_Spy0872 NC_008024.1 826196 826513 D phage protein 826196..826513 Streptococcus pyogenes MGAS10750 4066858 YP_602367.1 CDS MGAS10750_Spy0873 NC_008024.1 826486 826944 D phage protein 826486..826944 Streptococcus pyogenes MGAS10750 4066859 YP_602368.1 CDS MGAS10750_Spy0874 NC_008024.1 826937 828742 D phage protein 826937..828742 Streptococcus pyogenes MGAS10750 4066860 YP_602369.1 CDS MGAS10750_Spy0875 NC_008024.1 828743 830227 D phage tail protein 828743..830227 Streptococcus pyogenes MGAS10750 4066861 YP_602370.1 CDS MGAS10750_Spy0876 NC_008024.1 830228 833677 D phage protein 830228..833677 Streptococcus pyogenes MGAS10750 4066862 YP_602371.1 CDS MGAS10750_Spy0877 NC_008024.1 833682 835544 D phage structural protein 833682..835544 Streptococcus pyogenes MGAS10750 4066863 YP_602372.1 CDS MGAS10750_Spy0878 NC_008024.1 835555 835902 D phage protein 835555..835902 Streptococcus pyogenes MGAS10750 4066864 YP_602373.1 CDS MGAS10750_Spy0879 NC_008024.1 835874 836038 D phage protein 835874..836038 Streptococcus pyogenes MGAS10750 4066865 YP_602374.1 CDS MGAS10750_Spy0880 NC_008024.1 836007 836375 D phage protein 836007..836375 Streptococcus pyogenes MGAS10750 4066899 YP_602375.1 CDS MGAS10750_Spy0881 NC_008024.1 836375 836707 D N-acetylmuramoyl-L-alanine amidase 836375..836707 Streptococcus pyogenes MGAS10750 4066900 YP_602376.1 CDS MGAS10750_Spy0882 NC_008024.1 836709 837473 D phage-associated cell wall hydrolase 836709..837473 Streptococcus pyogenes MGAS10750 4066901 YP_602377.1 CDS MGAS10750_Spy0883 NC_008024.1 837485 838087 D phage protein 837485..838087 Streptococcus pyogenes MGAS10750 4066902 YP_602378.1 CDS MGAS10750_Spy0884 NC_008024.1 838098 838871 D phage protein 838098..838871 Streptococcus pyogenes MGAS10750 4066903 YP_602379.1 CDS MGAS10750_Spy0885 NC_008024.1 838881 839102 D phage protein 838881..839102 Streptococcus pyogenes MGAS10750 4066904 YP_602380.1 CDS MGAS10750_Spy0886 NC_008024.1 839102 839761 D phage protein 839102..839761 Streptococcus pyogenes MGAS10750 4066905 YP_602381.1 CDS MGAS10750_Spy0887 NC_008024.1 839830 840264 R hypothetical protein complement(839830..840264) Streptococcus pyogenes MGAS10750 4066906 YP_602382.1 CDS spd3 NC_008024.1 840536 841342 R Streptodornase complement(840536..841342) Streptococcus pyogenes MGAS10750 4066907 YP_602383.1 CDS MGAS10750_Spy0889 NC_008024.1 841574 841762 D phage protein 841574..841762 Streptococcus pyogenes MGAS10750 4066908 YP_602384.1 CDS MGAS10750_Spy0890 NC_008024.1 842170 842646 D 7,8-dihydro-8-oxoguanine-triphosphatase 842170..842646 Streptococcus pyogenes MGAS10750 4066909 YP_602385.1 CDS MGAS10750_Spy0891 NC_008024.1 842704 843885 D hypothetical protein 842704..843885 Streptococcus pyogenes MGAS10750 4066910 YP_602386.1 CDS MGAS10750_Spy0892 NC_008024.1 843857 845122 D hypothetical protein 843857..845122 Streptococcus pyogenes MGAS10750 4066911 YP_602387.1 CDS fbp NC_008024.1 845181 846875 R Fibronectin-binding protein / Fibrinogen-binding protein complement(845181..846875) Streptococcus pyogenes MGAS10750 4066912 YP_602388.1 CDS MGAS10750_Spy0894 NC_008024.1 846880 847005 D hypothetical protein 846880..847005 Streptococcus pyogenes MGAS10750 4066913 YP_602389.1 CDS MGAS10750_Spy0895 NC_008024.1 847187 848185 D ABC transporter substrate-binding protein 847187..848185 Streptococcus pyogenes MGAS10750 4066914 YP_602390.1 CDS MGAS10750_Spy0896 NC_008024.1 848136 848354 D hypothetical protein 848136..848354 Streptococcus pyogenes MGAS10750 4066915 YP_602391.1 CDS MGAS10750_Spy0897 NC_008024.1 848519 849400 D ABC transporter permease 848519..849400 Streptococcus pyogenes MGAS10750 4066916 YP_602392.1 CDS MGAS10750_Spy0898 NC_008024.1 849397 850155 D ABC transporter ATP-binding protein 849397..850155 Streptococcus pyogenes MGAS10750 4066917 YP_602393.1 CDS MGAS10750_Spy0899 NC_008024.1 850359 852020 D Zn-dependent hydrolase 850359..852020 Streptococcus pyogenes MGAS10750 4066918 YP_602394.1 CDS estA NC_008024.1 852153 852938 D acetyl esterase 852153..852938 Streptococcus pyogenes MGAS10750 4066919 YP_602395.1 CDS MGAS10750_Spy0901 NC_008024.1 852968 853294 D hypothetical protein 852968..853294 Streptococcus pyogenes MGAS10750 4066920 YP_602396.1 CDS MGAS10750_Spy0902 NC_008024.1 853340 855247 D ABC transporter ATP-binding protein 853340..855247 Streptococcus pyogenes MGAS10750 4066921 YP_602397.1 CDS acoA NC_008024.1 855521 856501 D Pyruvate dehydrogenase E1 component alpha subunit 855521..856501 Streptococcus pyogenes MGAS10750 4066922 YP_602398.1 CDS acoB NC_008024.1 856557 857558 D Pyruvate dehydrogenase E1 component beta subunit 856557..857558 Streptococcus pyogenes MGAS10750 4066923 YP_602399.1 CDS acoC NC_008024.1 857743 859152 D branched-chain alpha-keto acid dehydrogenase subunit E2 857743..859152 Streptococcus pyogenes MGAS10750 4066924 YP_602400.1 CDS MGAS10750_Spy0906 NC_008024.1 859163 859450 R hypothetical protein complement(859163..859450) Streptococcus pyogenes MGAS10750 4066925 YP_602401.1 CDS acoL NC_008024.1 859483 861246 D dihydrolipoamide dehydrogenase 859483..861246 Streptococcus pyogenes MGAS10750 4066926 YP_602402.1 CDS MGAS10750_Spy0908 NC_008024.1 861262 861474 R hypothetical protein complement(861262..861474) Streptococcus pyogenes MGAS10750 4066927 YP_602403.1 CDS hylA NC_008024.1 861733 864339 R Hyaluronate lyase precursor complement(861733..864339) Streptococcus pyogenes MGAS10750 4066928 YP_602404.1 CDS lplB NC_008024.1 864572 865561 D Lipoate-protein ligase A 864572..865561 Streptococcus pyogenes MGAS10750 4066929 YP_602405.1 CDS MGAS10750_Spy0911 NC_008024.1 865670 866461 R CobB/CobQ-like glutamine amidotransferase domain complement(865670..866461) Streptococcus pyogenes MGAS10750 4066930 YP_602406.1 CDS MGAS10750_Spy0912 NC_008024.1 866461 867804 R UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase complement(866461..867804) Streptococcus pyogenes MGAS10750 4066931 YP_602407.1 CDS MGAS10750_Spy0913 NC_008024.1 867911 868762 D hypothetical protein 867911..868762 Streptococcus pyogenes MGAS10750 4066932 YP_602408.1 CDS MGAS10750_Spy0914 NC_008024.1 868759 869715 D hypothetical protein 868759..869715 Streptococcus pyogenes MGAS10750 4066933 YP_602409.1 CDS glmM NC_008024.1 869769 871124 D catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 869769..871124 Streptococcus pyogenes MGAS10750 4066934 YP_602410.1 CDS MGAS10750_Spy0916 NC_008024.1 871248 871889 D hypothetical protein 871248..871889 Streptococcus pyogenes MGAS10750 4066935 YP_602411.1 CDS hemN NC_008024.1 871952 873082 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 871952..873082 Streptococcus pyogenes MGAS10750 4066936 YP_602412.1 CDS MGAS10750_Spy0918 NC_008024.1 873092 873844 D acyl-acyl-carrier protein thioesterase 873092..873844 Streptococcus pyogenes MGAS10750 4066937 YP_602413.1 CDS MGAS10750_Spy0919 NC_008024.1 873844 874608 D Haloacid dehalogenase-like hydrolase 873844..874608 Streptococcus pyogenes MGAS10750 4066654 YP_602414.1 CDS MGAS10750_Spy0920 NC_008024.1 874596 875240 D hypothetical protein 874596..875240 Streptococcus pyogenes MGAS10750 4066655 YP_602415.1 CDS MGAS10750_Spy0921 NC_008024.1 875719 879834 D hypothetical protein 875719..879834 Streptococcus pyogenes MGAS10750 4066656 YP_602416.1 CDS MGAS10750_Spy0922 NC_008024.1 879834 880703 D hypothetical protein 879834..880703 Streptococcus pyogenes MGAS10750 4066657 YP_602417.1 CDS MGAS10750_Spy0923 NC_008024.1 880700 881041 D hypothetical protein 880700..881041 Streptococcus pyogenes MGAS10750 4066658 YP_602418.1 CDS MGAS10750_Spy0924 NC_008024.1 880965 881693 D hypothetical protein 880965..881693 Streptococcus pyogenes MGAS10750 4066659 YP_602419.1 CDS MGAS10750_Spy0925 NC_008024.1 882010 882141 D nucleoside diphosphate kinase 882010..882141 Streptococcus pyogenes MGAS10750 4066660 YP_602420.1 CDS MGAS10750_Spy0926 NC_008024.1 882209 882409 D nucleoside diphosphate kinase 882209..882409 Streptococcus pyogenes MGAS10750 4066661 YP_602421.1 CDS lepA NC_008024.1 882479 884296 D binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 882479..884296 Streptococcus pyogenes MGAS10750 4066662 YP_602422.1 CDS MGAS10750_Spy0928 NC_008024.1 884501 885787 D Collagen-like surface protein 884501..885787 Streptococcus pyogenes MGAS10750 4066663 YP_602423.1 CDS msrB NC_008024.1 885973 886410 D this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 885973..886410 Streptococcus pyogenes MGAS10750 4066664 YP_602424.1 CDS MGAS10750_Spy0930 NC_008024.1 886540 887559 D hypothetical protein 886540..887559 Streptococcus pyogenes MGAS10750 4066665 YP_602425.1 CDS MGAS10750_Spy0931 NC_008024.1 887766 888191 D PTS system, mannose/fructose family IIA component 887766..888191 Streptococcus pyogenes MGAS10750 4066666 YP_602426.1 CDS ptsB NC_008024.1 888218 888709 D PTS system, mannose/fructose family IIB component 888218..888709 Streptococcus pyogenes MGAS10750 4066667 YP_602427.1 CDS ptsC NC_008024.1 888726 889535 D PTS system, mannose/fructose family IIC component 888726..889535 Streptococcus pyogenes MGAS10750 4066668 YP_602428.1 CDS ptsD NC_008024.1 889532 890359 D PTS system, mannose/fructose family IID component 889532..890359 Streptococcus pyogenes MGAS10750 4066669 YP_602429.1 CDS MGAS10750_Spy0935 NC_008024.1 890495 892144 D two-component sensor kinase yesM 890495..892144 Streptococcus pyogenes MGAS10750 4066670 YP_602430.1 CDS MGAS10750_Spy0936 NC_008024.1 892148 892936 D two-component response regulator yesN 892148..892936 Streptococcus pyogenes MGAS10750 4066671 YP_602431.1 CDS MGAS10750_Spy0937 NC_008024.1 892930 893976 D Iron(III)-binding protein 892930..893976 Streptococcus pyogenes MGAS10750 4066672 YP_602432.1 CDS gabD NC_008024.1 894088 895488 D Succinate-semialdehyde dehydrogenase (NADP+) 894088..895488 Streptococcus pyogenes MGAS10750 4066479 YP_602433.1 CDS uvrC NC_008024.1 895590 897386 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 895590..897386 Streptococcus pyogenes MGAS10750 4066480 YP_602434.1 CDS MGAS10750_Spy0940 NC_008024.1 897570 898172 D NAD(P)H-dependent quinone reductase 897570..898172 Streptococcus pyogenes MGAS10750 4066481 YP_602435.2 CDS MGAS10750_Spy0941 NC_008024.1 898297 899706 D divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases; dipeptidase PepV 898297..899706 Streptococcus pyogenes MGAS10750 4066482 YP_602436.1 CDS trmE NC_008024.1 899774 901150 R in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE complement(899774..901150) Streptococcus pyogenes MGAS10750 4066483 YP_602437.2 CDS rplJ NC_008024.1 901486 901986 D binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 901486..901986 Streptococcus pyogenes MGAS10750 4066484 YP_602438.1 CDS rplL NC_008024.1 902036 902416 D present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 902036..902416 Streptococcus pyogenes MGAS10750 4066485 YP_602439.1 CDS MGAS10750_Spy0945 NC_008024.1 902811 902972 D hypothetical protein 902811..902972 Streptococcus pyogenes MGAS10750 4066486 YP_602440.1 CDS MGAS10750_Spy0946 NC_008024.1 902966 903334 D hypothetical protein 902966..903334 Streptococcus pyogenes MGAS10750 4066487 YP_602441.1 CDS MGAS10750_Spy0947 NC_008024.1 903351 903455 D hypothetical protein 903351..903455 Streptococcus pyogenes MGAS10750 4066488 YP_602442.1 CDS MGAS10750_Spy0948 NC_008024.1 903505 903864 D DNA-cytosine methyltransferase 903505..903864 Streptococcus pyogenes MGAS10750 4066489 YP_602443.1 CDS MGAS10750_Spy0949 NC_008024.1 903897 904109 D Relaxase 903897..904109 Streptococcus pyogenes MGAS10750 4066490 YP_602444.1 CDS MGAS10750_Spy0950 NC_008024.1 904152 904364 D Relaxase 904152..904364 Streptococcus pyogenes MGAS10750 4066491 YP_602445.1 CDS MGAS10750_Spy0951 NC_008024.1 904629 904940 D Relaxase 904629..904940 Streptococcus pyogenes MGAS10750 4066492 YP_602446.1 CDS srtI NC_008024.1 905009 905326 D Relaxase 905009..905326 Streptococcus pyogenes MGAS10750 4066493 YP_602447.1 CDS srtR NC_008024.1 905477 906163 D lantibiotic biosynthesis two-component response regulator 905477..906163 Streptococcus pyogenes MGAS10750 4066494 YP_602448.1 CDS srtK NC_008024.1 906141 907502 D lantibiotic biosynthesis sensor protein 906141..907502 Streptococcus pyogenes MGAS10750 4066495 YP_602449.1 CDS srtA NC_008024.1 907659 907799 D lantibiotic srtA precursor 907659..907799 Streptococcus pyogenes MGAS10750 4066496 YP_602450.1 CDS srtT NC_008024.1 907914 909704 D lantibiotic transport permease / lantibiotic transport ATP-binding protein 907914..909704 Streptococcus pyogenes MGAS10750 4066497 YP_602451.1 CDS MGAS10750_Spy0957 NC_008024.1 909676 910932 D lantibiotic biosynthesis; Lanthionine synthetase 909676..910932 Streptococcus pyogenes MGAS10750 4066498 YP_602452.1 CDS MGAS10750_Spy0958 NC_008024.1 910951 913917 D lantibiotic biosynthesis; serine/threoninedehydratase 910951..913917 Streptococcus pyogenes MGAS10750 4067056 YP_602453.1 CDS srtF NC_008024.1 913866 914612 D lantibiotic transport ATP-binding protein 913866..914612 Streptococcus pyogenes MGAS10750 4067057 YP_602454.1 CDS srtE NC_008024.1 914618 915367 D lantibiotic transport permease 914618..915367 Streptococcus pyogenes MGAS10750 4067058 YP_602455.1 CDS srtG NC_008024.1 915370 916092 D lantibiotic transport permease 915370..916092 Streptococcus pyogenes MGAS10750 4067059 YP_602456.1 CDS MGAS10750_Spy0962 NC_008024.1 916284 916502 D Cro/CI family transcriptional regulator 916284..916502 Streptococcus pyogenes MGAS10750 4067060 YP_602457.1 CDS MGAS10750_Spy0964 NC_008024.1 916611 916913 R hypothetical protein complement(916611..916913) Streptococcus pyogenes MGAS10750 4067061 YP_602458.1 CDS MGAS10750_Spy0963 NC_008024.1 916800 917024 D hypothetical protein 916800..917024 Streptococcus pyogenes MGAS10750 4067062 YP_602459.1 CDS MGAS10750_Spy0965 NC_008024.1 917027 917158 D DNA integration/recombination/inversion protein 917027..917158 Streptococcus pyogenes MGAS10750 4067063 YP_602460.1 CDS MGAS10750_Spy0966 NC_008024.1 917485 917706 D DNA integration/recombination/inversion protein 917485..917706 Streptococcus pyogenes MGAS10750 4067064 YP_602461.1 CDS MGAS10750_Spy0967 NC_008024.1 917737 918225 D DNA integration/recombination/inversion protein 917737..918225 Streptococcus pyogenes MGAS10750 4067065 YP_602462.1 CDS dacA1 NC_008024.1 918263 919618 D D-alanyl-D-alanine serine-type carboxypeptidase 918263..919618 Streptococcus pyogenes MGAS10750 4067066 YP_602463.1 CDS MGAS10750_Spy0969 NC_008024.1 919735 920697 R Polysaccharide deacetylase complement(919735..920697) Streptococcus pyogenes MGAS10750 4067067 YP_602464.1 CDS MGAS10750_Spy0970 NC_008024.1 920785 920940 D hypothetical protein 920785..920940 Streptococcus pyogenes MGAS10750 4067068 YP_602465.1 CDS folC1 NC_008024.1 920930 922306 D bifunctional; Folylpolyglutamate synthase / dihydrofolate synthase 920930..922306 Streptococcus pyogenes MGAS10750 4067069 YP_602466.1 CDS folE NC_008024.1 922317 922919 D involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 922317..922919 Streptococcus pyogenes MGAS10750 4067070 YP_602467.1 CDS folP NC_008024.1 922928 923719 D dihydropteroate synthase 922928..923719 Streptococcus pyogenes MGAS10750 4067071 YP_602468.1 CDS folQ NC_008024.1 923735 924094 D dihydroneopterin aldolase 923735..924094 Streptococcus pyogenes MGAS10750 4067072 YP_602469.1 CDS folK NC_008024.1 924091 924591 D 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 924091..924591 Streptococcus pyogenes MGAS10750 4067073 YP_602470.1 CDS murB NC_008024.1 924741 925628 D catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 924741..925628 Streptococcus pyogenes MGAS10750 4067074 YP_602471.1 CDS potA NC_008024.1 925674 926828 D Spermidine/putrescine transport ATP-binding protein potA 925674..926828 Streptococcus pyogenes MGAS10750 4067095 YP_602472.1 CDS potB NC_008024.1 926791 927606 D Spermidine/putrescine transport system permease potB 926791..927606 Streptococcus pyogenes MGAS10750 4067096 YP_602473.1 CDS potC NC_008024.1 927603 928379 D Spermidine/putrescine transport system permease potC 927603..928379 Streptococcus pyogenes MGAS10750 4067097 YP_602474.1 CDS MGAS10750_Spy0980 NC_008024.1 928372 929445 D Spermidine/putrescine-binding protein 928372..929445 Streptococcus pyogenes MGAS10750 4067098 YP_602475.1 CDS dpiA NC_008024.1 929500 930165 R DpiA family transcriptional regulator complement(929500..930165) Streptococcus pyogenes MGAS10750 4067099 YP_602476.1 CDS dpiB NC_008024.1 930146 931687 R Sensor kinase dpiB complement(930146..931687) Streptococcus pyogenes MGAS10750 4067100 YP_602477.1 CDS malP NC_008024.1 931848 933179 D Malate-sodium symport 931848..933179 Streptococcus pyogenes MGAS10750 4067101 YP_602478.1 CDS MGAS10750_Spy0984 NC_008024.1 933210 934376 D NAD-dependent malic enzyme 933210..934376 Streptococcus pyogenes MGAS10750 4067102 YP_602479.1 CDS MGAS10750_Spy0985 NC_008024.1 934458 935549 R Zn-dependent alcohol dehydrogenase complement(934458..935549) Streptococcus pyogenes MGAS10750 4067103 YP_602480.1 CDS aphA NC_008024.1 935743 936474 D Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 935743..936474 Streptococcus pyogenes MGAS10750 4067104 YP_602481.1 CDS MGAS10750_Spy0987 NC_008024.1 937613 938185 D chloride channel protein 937613..938185 Streptococcus pyogenes MGAS10750 4067105 YP_602482.1 CDS MGAS10750_Spy0988 NC_008024.1 938348 938962 D Lipase/acylhydrolase family protein 938348..938962 Streptococcus pyogenes MGAS10750 4067106 YP_602483.1 CDS MGAS10750_Spy0989 NC_008024.1 939008 939121 D hypothetical protein 939008..939121 Streptococcus pyogenes MGAS10750 4067107 YP_602484.1 CDS MGAS10750_Spy0990 NC_008024.1 939121 940269 D hypothetical protein 939121..940269 Streptococcus pyogenes MGAS10750 4067108 YP_602485.1 CDS radC NC_008024.1 940318 940998 D Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 940318..940998 Streptococcus pyogenes MGAS10750 4067109 YP_602486.1 CDS MGAS10750_Spy0992 NC_008024.1 941000 941695 R glutamine amidotransferase, class I complement(941000..941695) Streptococcus pyogenes MGAS10750 4067110 YP_602487.1 CDS MGAS10750_Spy0993 NC_008024.1 941705 942349 R modulates transcription in response to the NADH/NAD(+) redox state; redox-sensing transcriptional repressor Rex complement(941705..942349) Streptococcus pyogenes MGAS10750 4067111 YP_602488.1 CDS MGAS10750_Spy0994 NC_008024.1 942600 942947 R hypothetical protein complement(942600..942947) Streptococcus pyogenes MGAS10750 4067112 YP_602489.1 CDS nifS2 NC_008024.1 942937 944064 R bifunctional; cysteine desulfurase / Selenocysteine lyase complement(942937..944064) Streptococcus pyogenes MGAS10750 4067113 YP_602490.1 CDS MGAS10750_Spy0996 NC_008024.1 944061 945041 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(944061..945041) Streptococcus pyogenes MGAS10750 4067114 YP_602491.1 CDS MGAS10750_Spy0997 NC_008024.1 945181 945759 R Organic phosphate binding CYTH family protein complement(945181..945759) Streptococcus pyogenes MGAS10750 4067203 YP_602492.1 CDS MGAS10750_Spy0998 NC_008024.1 945847 946518 D GTP pyrophosphokinase-like protein 945847..946518 Streptococcus pyogenes MGAS10750 4067204 YP_602493.1 CDS ppnK NC_008024.1 946490 947329 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 946490..947329 Streptococcus pyogenes MGAS10750 4067205 YP_602494.1 CDS MGAS10750_Spy1000 NC_008024.1 947326 948231 D ribosomal large subunit pseudouridine synthase D 947326..948231 Streptococcus pyogenes MGAS10750 4067206 YP_602495.1 CDS eutD NC_008024.1 948235 949230 D in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 948235..949230 Streptococcus pyogenes MGAS10750 4067207 YP_602496.1 CDS MGAS10750_Spy1002 NC_008024.1 949339 950112 D Short chain dehydrogenase 949339..950112 Streptococcus pyogenes MGAS10750 4067208 YP_602497.1 CDS MGAS10750_Spy1003 NC_008024.1 950305 950994 R Na+ driven multidrug efflux pump complement(950305..950994) Streptococcus pyogenes MGAS10750 4067209 YP_602498.1 CDS proV NC_008024.1 951417 952145 D glycine betaine transport ATP-binding protein 951417..952145 Streptococcus pyogenes MGAS10750 4067210 YP_602499.1 CDS MGAS10750_Spy1005 NC_008024.1 952102 953664 D glycine betaine transport system permease / glycine betaine-binding protein 952102..953664 Streptococcus pyogenes MGAS10750 4067211 YP_602500.1 CDS guaC NC_008024.1 953921 954925 D guanosine 5'-monophosphate oxidoreductase 953921..954925 Streptococcus pyogenes MGAS10750 4067212 YP_602501.1 CDS xpt NC_008024.1 955230 955811 D Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine; xanthine phosphoribosyltransferase 955230..955811 Streptococcus pyogenes MGAS10750 4067213 YP_602502.1 CDS MGAS10750_Spy1008 NC_008024.1 955811 957094 D Xanthine permease 955811..957094 Streptococcus pyogenes MGAS10750 4067214 YP_602503.1 CDS apbE NC_008024.1 957158 958096 R Iron-sulfur cluster assembly/repair protein ApbE complement(957158..958096) Streptococcus pyogenes MGAS10750 4067215 YP_602504.1 CDS MGAS10750_Spy1010 NC_008024.1 958149 958334 R 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase complement(958149..958334) Streptococcus pyogenes MGAS10750 4067216 YP_602505.1 CDS tdk2 NC_008024.1 958472 959041 D catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 958472..959041 Streptococcus pyogenes MGAS10750 4067217 YP_602506.1 CDS prfA NC_008024.1 959076 960155 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 959076..960155 Streptococcus pyogenes MGAS10750 4067218 YP_602507.1 CDS hemK NC_008024.1 960155 960994 D Peptide release factor-glutamine N5-methyltransferase 960155..960994 Streptococcus pyogenes MGAS10750 4067219 YP_602508.1 CDS MGAS10750_Spy1014 NC_008024.1 960948 961568 D Sua5/YciO/YrdC/YwlC family protein 960948..961568 Streptococcus pyogenes MGAS10750 4067220 YP_602509.1 CDS MGAS10750_Spy1015 NC_008024.1 961586 962038 D phosphinothricin N-acetyltransferase 961586..962038 Streptococcus pyogenes MGAS10750 4067221 YP_602510.1 CDS glyA NC_008024.1 962022 963284 D catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 962022..963284 Streptococcus pyogenes MGAS10750 4067316 YP_602511.1 CDS MGAS10750_Spy1017 NC_008024.1 963291 964268 D hypothetical protein 963291..964268 Streptococcus pyogenes MGAS10750 4067317 YP_602512.1 CDS MGAS10750_Spy1018 NC_008024.1 964269 964880 D antigen-like protein 964269..964880 Streptococcus pyogenes MGAS10750 4067318 YP_602513.1 CDS MGAS10750_Spy1019 NC_008024.1 964877 966601 D multidrug resistance ABC transporter ATP-binding and permease 964877..966601 Streptococcus pyogenes MGAS10750 4067319 YP_602514.1 CDS MGAS10750_Spy1020 NC_008024.1 966598 968325 D multidrug/protein/lipid ABC transporter family, ATP-binding and permease 966598..968325 Streptococcus pyogenes MGAS10750 4067320 YP_602515.1 CDS nox NC_008024.1 968567 969937 D NADH oxidase H2O-forming 968567..969937 Streptococcus pyogenes MGAS10750 4067321 YP_602516.1 CDS ldh NC_008024.1 970096 971079 R Converts (S)-lactate and NAD(+) to pyruvate and NADH; L-lactate dehydrogenase complement(970096..971079) Streptococcus pyogenes MGAS10750 4067322 YP_602517.1 CDS gyrA NC_008024.1 971270 973756 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 971270..973756 Streptococcus pyogenes MGAS10750 4067323 YP_602518.1 CDS MGAS10750_Spy1024 NC_008024.1 973776 974525 D Sortase 973776..974525 Streptococcus pyogenes MGAS10750 4067324 YP_602519.1 CDS MGAS10750_Spy1025 NC_008024.1 974608 975021 D Glyoxalase family protein 974608..975021 Streptococcus pyogenes MGAS10750 4067325 YP_602520.1 CDS MGAS10750_Spy1026 NC_008024.1 975496 975627 D hypothetical protein 975496..975627 Streptococcus pyogenes MGAS10750 4067326 YP_602521.1 CDS MGAS10750_Spy1027 NC_008024.1 975578 976069 D hypothetical protein 975578..976069 Streptococcus pyogenes MGAS10750 4067327 YP_602522.1 CDS MGAS10750_Spy1028 NC_008024.1 976119 977030 R Diacylglycerol kinase family protein complement(976119..977030) Streptococcus pyogenes MGAS10750 4067328 YP_602523.1 CDS MGAS10750_Spy1029 NC_008024.1 977147 977797 R hemolysin III homolog; hypothetical protein complement(977147..977797) Streptococcus pyogenes MGAS10750 4067329 YP_602524.1 CDS MGAS10750_Spy1030 NC_008024.1 977794 978234 R hypothetical protein complement(977794..978234) Streptococcus pyogenes MGAS10750 4067330 YP_602525.1 CDS rbgA NC_008024.1 978453 979301 D essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc); ribosomal biogenesis GTPase 978453..979301 Streptococcus pyogenes MGAS10750 4067331 YP_602526.1 CDS rnhB NC_008024.1 979291 980082 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 979291..980082 Streptococcus pyogenes MGAS10750 4067332 YP_602527.1 CDS smf NC_008024.1 980147 980983 D DNA processing protein 980147..980983 Streptococcus pyogenes MGAS10750 4067333 YP_602528.1 CDS MGAS10750_Spy1034 NC_008024.1 981090 983219 D catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 981090..983219 Streptococcus pyogenes MGAS10750 4067334 YP_602529.1 CDS MGAS10750_Spy1035 NC_008024.1 983295 983777 R LysR family transcriptional regulator complement(983295..983777) Streptococcus pyogenes MGAS10750 4067335 YP_602530.1 CDS MGAS10750_Spy1036 NC_008024.1 983784 983906 R LysR family transcriptional regulator complement(983784..983906) Streptococcus pyogenes MGAS10750 4068501 YP_602531.1 CDS MGAS10750_Spy1038 NC_008024.1 984054 984203 R LysR family transcriptional regulator complement(984054..984203) Streptococcus pyogenes MGAS10750 4068502 YP_602532.1 CDS MGAS10750_Spy1037 NC_008024.1 984192 984758 D hypothetical protein 984192..984758 Streptococcus pyogenes MGAS10750 4068503 YP_602533.1 CDS ddh NC_008024.1 984770 985765 D catalyzes the formation of pyruvate from lactate; D-lactate dehydrogenase 984770..985765 Streptococcus pyogenes MGAS10750 4068504 YP_602534.1 CDS satD NC_008024.1 985870 986535 D hypothetical protein 985870..986535 Streptococcus pyogenes MGAS10750 4068505 YP_602535.1 CDS satE NC_008024.1 986528 987244 D hypothetical protein 986528..987244 Streptococcus pyogenes MGAS10750 4068506 YP_602536.1 CDS gid NC_008024.1 987347 988741 D TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine; tRNA (uracil-5-)-methyltransferase Gid 987347..988741 Streptococcus pyogenes MGAS10750 4068507 YP_602537.1 CDS oadA2 NC_008024.1 988894 990300 D Converts oxaloacetate to phosphoenolpyruvate using ATP as an energy source; oxaloacetate decarboxylase 988894..990300 Streptococcus pyogenes MGAS10750 4068508 YP_602538.1 CDS MGAS10750_Spy1044 NC_008024.1 990343 990657 D hypothetical protein 990343..990657 Streptococcus pyogenes MGAS10750 4068509 YP_602539.1 CDS MGAS10750_Spy1045 NC_008024.1 990657 991007 D Biotin carboxyl carrier protein of oxaloacetate decarboxylase 990657..991007 Streptococcus pyogenes MGAS10750 4068510 YP_602540.1 CDS MGAS10750_Spy1046 NC_008024.1 991017 992147 D Na+ transporting oxaloacetate decarboxylase beta chain 991017..992147 Streptococcus pyogenes MGAS10750 4068511 YP_602541.1 CDS MGAS10750_Spy1047 NC_008024.1 992348 993232 R 2'-(5''-triphosphoribosyl)-3-dephospho-CoA synthase complement(992348..993232) Streptococcus pyogenes MGAS10750 4068512 YP_602542.1 CDS citG NC_008024.1 993225 993920 R GntR family transcriptional regulator complement(993225..993920) Streptococcus pyogenes MGAS10750 4068513 YP_602543.1 CDS MGAS10750_Spy1049 NC_008024.1 994078 995502 R hypothetical protein complement(994078..995502) Streptococcus pyogenes MGAS10750 4068514 YP_602544.1 CDS MGAS10750_Spy1050 NC_008024.1 995861 996184 D hypothetical protein 995861..996184 Streptococcus pyogenes MGAS10750 4068515 YP_602545.2 CDS MGAS10750_Spy1051 NC_008024.1 996238 996636 D composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 996238..996636 Streptococcus pyogenes MGAS10750 4068516 YP_602546.1 CDS oadB NC_008024.1 996681 997388 D Na+ transporting oxaloacetate decarboxylase beta chain 996681..997388 Streptococcus pyogenes MGAS10750 4068517 YP_602547.1 CDS MGAS10750_Spy1053 NC_008024.1 997375 997803 D Na+ transporting oxaloacetate decarboxylase beta chain 997375..997803 Streptococcus pyogenes MGAS10750 4068518 YP_602548.1 CDS MGAS10750_Spy1054 NC_008024.1 997821 997955 D hypothetical protein 997821..997955 Streptococcus pyogenes MGAS10750 4068519 YP_602549.1 CDS citD NC_008024.1 997991 998299 D acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma 997991..998299 Streptococcus pyogenes MGAS10750 4066558 YP_602550.1 CDS citE NC_008024.1 998287 999174 D bifunctional; citrate lyase subunit beta 998287..999174 Streptococcus pyogenes MGAS10750 4066559 YP_602551.1 CDS citF NC_008024.1 999177 1000709 D bifunctional; citrate lyase subunit alpha 999177..1000709 Streptococcus pyogenes MGAS10750 4066560 YP_602552.1 CDS citX NC_008024.1 1000651 1001280 D 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate; 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA:apo- citrate lyase 1000651..1001280 Streptococcus pyogenes MGAS10750 4066561 YP_602553.1 CDS oadA1 NC_008024.1 1001277 1002689 D Converts oxaloacetate to phosphoenolpyruvate using ATP as an energy source; oxaloacetate decarboxylase 1001277..1002689 Streptococcus pyogenes MGAS10750 4066562 YP_602554.1 CDS citC NC_008024.1 1002799 1003851 R (Citrate (pro-3S)-lyase) ligase complement(1002799..1003851) Streptococcus pyogenes MGAS10750 4066563 YP_602555.1 CDS MGAS10750_Spy1061 NC_008024.1 1003940 1004422 R hypothetical protein complement(1003940..1004422) Streptococcus pyogenes MGAS10750 4066564 YP_602556.1 CDS xerS NC_008024.1 1005122 1006243 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS; site-specific tyrosine recombinase XerS complement(1005122..1006243) Streptococcus pyogenes MGAS10750 4066565 YP_602557.1 CDS MGAS10750_Spy1063 NC_008024.1 1006666 1007364 D phage transcriptional repressor 1006666..1007364 Streptococcus pyogenes MGAS10750 4066566 YP_602558.1 CDS ffh NC_008024.1 1007481 1009049 R signal recognition particle subunit FFH/SRP54 complement(1007481..1009049) Streptococcus pyogenes MGAS10750 4066567 YP_602559.1 CDS ylxM NC_008024.1 1009058 1009399 R DNA-binding protein complement(1009058..1009399) Streptococcus pyogenes MGAS10750 4066568 YP_602560.1 CDS MGAS10750_Spy1066 NC_008024.1 1009488 1010213 R GntR family transcriptional regulator complement(1009488..1010213) Streptococcus pyogenes MGAS10750 4066569 YP_602561.1 CDS MGAS10750_Spy1067 NC_008024.1 1010269 1011702 R hypothetical protein complement(1010269..1011702) Streptococcus pyogenes MGAS10750 4066570 YP_602562.1 CDS guaA NC_008024.1 1011869 1013431 D contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 1011869..1013431 Streptococcus pyogenes MGAS10750 4066571 YP_602563.1 CDS MGAS10750_Spy1069 NC_008024.1 1013473 1014696 R bifunctional; UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase / UDP-N-acetylmuramoylpentapeptide-lysine N(6)-seryltransferase complement(1013473..1014696) Streptococcus pyogenes MGAS10750 4066572 YP_602564.1 CDS MGAS10750_Spy1070 NC_008024.1 1015061 1016641 R ABC transporter ATP-binding protein complement(1015061..1016641) Streptococcus pyogenes MGAS10750 4066573 YP_602565.1 CDS pdxK NC_008024.1 1016739 1017296 R hypothetical protein complement(1016739..1017296) Streptococcus pyogenes MGAS10750 4066574 YP_602566.1 CDS MGAS10750_Spy1072 NC_008024.1 1017274 1018140 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase complement(1017274..1018140) Streptococcus pyogenes MGAS10750 4066575 YP_602567.1 CDS MGAS10750_Spy1073 NC_008024.1 1018230 1019498 D GntR family transcriptional regulator 1018230..1019498 Streptococcus pyogenes MGAS10750 4066576 YP_602568.1 CDS rnhB NC_008024.1 1019969 1020325 R Anaerobic ribonucleoside-triphosphate reductase complement(1019969..1020325) Streptococcus pyogenes MGAS10750 4066577 YP_602569.1 CDS MGAS10750_Spy1075 NC_008024.1 1020647 1022224 R cardiolipin synthetase complement(1020647..1022224) Streptococcus pyogenes MGAS10750 4066938 YP_602570.1 CDS fhs1 NC_008024.1 1022309 1023979 R catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase complement(1022309..1023979) Streptococcus pyogenes MGAS10750 4066939 YP_602571.1 CDS lplA NC_008024.1 1024107 1025126 R Lipoate-protein ligase A complement(1024107..1025126) Streptococcus pyogenes MGAS10750 4066940 YP_602572.1 CDS MGAS10750_Spy1078 NC_008024.1 1025173 1026054 R SIR2 family protein complement(1025173..1026054) Streptococcus pyogenes MGAS10750 4066941 YP_602573.1 CDS MGAS10750_Spy1079 NC_008024.1 1026047 1026859 R hypothetical protein complement(1026047..1026859) Streptococcus pyogenes MGAS10750 4066942 YP_602574.1 CDS MGAS10750_Spy1080 NC_008024.1 1026852 1027184 R glycine cleavage system H protein complement(1026852..1027184) Streptococcus pyogenes MGAS10750 4066943 YP_602575.1 CDS MGAS10750_Spy1081 NC_008024.1 1027226 1028224 R Luciferase-like monooxygenase complement(1027226..1028224) Streptococcus pyogenes MGAS10750 4066944 YP_602576.1 CDS MGAS10750_Spy1082 NC_008024.1 1028221 1029420 R Probable NADH-dependent flavin oxidoreductase yqiG complement(1028221..1029420) Streptococcus pyogenes MGAS10750 4066945 YP_602577.1 CDS MGAS10750_Spy1083 NC_008024.1 1029417 1030268 R Lipoate-protein ligase A complement(1029417..1030268) Streptococcus pyogenes MGAS10750 4066946 YP_602578.1 CDS dpfB NC_008024.1 1030449 1031141 D phosphopantothenate--cysteine ligase 1030449..1031141 Streptococcus pyogenes MGAS10750 4066947 YP_602579.1 CDS dfp NC_008024.1 1031134 1031679 D decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.; phosphopantothenoylcysteine decarboxylase 1031134..1031679 Streptococcus pyogenes MGAS10750 4066948 YP_602580.1 CDS MGAS10750_Spy1086 NC_008024.1 1031725 1032306 D membrane protein 1031725..1032306 Streptococcus pyogenes MGAS10750 4066949 YP_602581.1 CDS pgmA NC_008024.1 1032482 1034200 D bifunctional; phosphoglucomutase / phosphomannomutase 1032482..1034200 Streptococcus pyogenes MGAS10750 4066950 YP_602582.1 CDS MGAS10750_Spy1088 NC_008024.1 1034413 1035381 R nucleoside transport system permease complement(1034413..1035381) Streptococcus pyogenes MGAS10750 4066951 YP_602583.1 CDS MGAS10750_Spy1089 NC_008024.1 1035371 1036462 R nucleoside transport system permease complement(1035371..1036462) Streptococcus pyogenes MGAS10750 4066952 YP_602584.1 CDS MGAS10750_Spy1090 NC_008024.1 1036428 1037978 R nucleoside transport ATP-binding protein complement(1036428..1037978) Streptococcus pyogenes MGAS10750 4066953 YP_602585.1 CDS MGAS10750_Spy1091 NC_008024.1 1038099 1039151 R nucleoside-binding protein complement(1038099..1039151) Streptococcus pyogenes MGAS10750 4066954 YP_602586.1 CDS cdd NC_008024.1 1039245 1039634 R Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase complement(1039245..1039634) Streptococcus pyogenes MGAS10750 4066955 YP_602587.1 CDS MGAS10750_Spy1093 NC_008024.1 1040287 1040913 R 16S rRNA m(2)G 1207 methyltransferase complement(1040287..1040913) Streptococcus pyogenes MGAS10750 4066956 YP_602588.1 CDS coaA NC_008024.1 1041148 1042068 D catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 1041148..1042068 Streptococcus pyogenes MGAS10750 4068176 YP_602589.2 CDS rpsT NC_008024.1 1042137 1042370 D binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 1042137..1042370 Streptococcus pyogenes MGAS10750 4068177 YP_602590.1 CDS ciaH NC_008024.1 1042495 1043805 R Sensor protein ciaH complement(1042495..1043805) Streptococcus pyogenes MGAS10750 4068178 YP_602591.1 CDS ciaR NC_008024.1 1043798 1044472 R CiaR family transcriptional regulator complement(1043798..1044472) Streptococcus pyogenes MGAS10750 4068179 YP_602592.1 CDS pepN NC_008024.1 1044819 1047416 R bifunctional; Lysyl aminopeptidase / alanine aminopeptidase complement(1044819..1047416) Streptococcus pyogenes MGAS10750 4068180 YP_602593.1 CDS MGAS10750_Spy1099 NC_008024.1 1047413 1047607 R hypothetical protein complement(1047413..1047607) Streptococcus pyogenes MGAS10750 4068181 YP_602594.1 CDS phoU NC_008024.1 1047561 1048214 R phosphate transport system protein phoU complement(1047561..1048214) Streptococcus pyogenes MGAS10750 4068182 YP_602595.1 CDS pstB NC_008024.1 1048282 1049043 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(1048282..1049043) Streptococcus pyogenes MGAS10750 4068183 YP_602596.1 CDS pstB2 NC_008024.1 1049053 1049856 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(1049053..1049856) Streptococcus pyogenes MGAS10750 4068184 YP_602597.1 CDS pstA NC_008024.1 1049872 1050759 R phosphate transport system permease pstA complement(1049872..1050759) Streptococcus pyogenes MGAS10750 4068185 YP_602598.1 CDS pstC NC_008024.1 1050749 1051684 R phosphate transport system permease pstC complement(1050749..1051684) Streptococcus pyogenes MGAS10750 4068186 YP_602599.1 CDS pstS NC_008024.1 1051695 1052561 R phosphate-binding protein complement(1051695..1052561) Streptococcus pyogenes MGAS10750 4068187 YP_602600.1 CDS MGAS10750_Spy1106 NC_008024.1 1052700 1054010 R 23S rRNA m(5)C methyltransferase complement(1052700..1054010) Streptococcus pyogenes MGAS10750 4068188 YP_602601.1 CDS MGAS10750_Spy1107 NC_008024.1 1054013 1054450 R Myo-inositol-1(or 4)-monophosphatase complement(1054013..1054450) Streptococcus pyogenes MGAS10750 4068189 YP_602602.1 CDS MGAS10750_Spy1108 NC_008024.1 1054447 1054821 R Myo-inositol-1(or 4)-monophosphatase complement(1054447..1054821) Streptococcus pyogenes MGAS10750 4068190 YP_602603.1 CDS MGAS10750_Spy1109 NC_008024.1 1054790 1055080 R hypothetical protein complement(1054790..1055080) Streptococcus pyogenes MGAS10750 4068191 YP_602604.1 CDS spxA NC_008024.1 1055070 1055474 R the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; Spx family transcriptional regulator complement(1055070..1055474) Streptococcus pyogenes MGAS10750 4068192 YP_602605.1 CDS mreA NC_008024.1 1055517 1056449 R catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase complement(1055517..1056449) Streptococcus pyogenes MGAS10750 4068193 YP_602606.1 CDS truB NC_008024.1 1056478 1057362 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(1056478..1057362) Streptococcus pyogenes MGAS10750 4068194 YP_602607.1 CDS MGAS10750_Spy1113 NC_008024.1 1057478 1058818 R hypothetical protein complement(1057478..1058818) Streptococcus pyogenes MGAS10750 4068195 YP_602608.1 CDS MGAS10750_Spy1114 NC_008024.1 1058915 1059871 R membrane protein complement(1058915..1059871) Streptococcus pyogenes MGAS10750 4067258 YP_602609.1 CDS MGAS10750_Spy1115 NC_008024.1 1059882 1060478 R Type I restriction-modification system specificity subunit complement(1059882..1060478) Streptococcus pyogenes MGAS10750 4067259 YP_602610.1 CDS MGAS10750_Spy1116 NC_008024.1 1060570 1063206 R ABC transporter permease complement(1060570..1063206) Streptococcus pyogenes MGAS10750 4067260 YP_602611.1 CDS MGAS10750_Spy1117 NC_008024.1 1063221 1063934 R ABC transporter ATP-binding protein complement(1063221..1063934) Streptococcus pyogenes MGAS10750 4067261 YP_602612.1 CDS MGAS10750_Spy1118 NC_008024.1 1064040 1064582 D TetR family transcriptional regulator 1064040..1064582 Streptococcus pyogenes MGAS10750 4067262 YP_602613.1 CDS MGAS10750_Spy1119 NC_008024.1 1064579 1064722 R hypothetical protein complement(1064579..1064722) Streptococcus pyogenes MGAS10750 4067263 YP_602614.1 CDS MGAS10750_Spy1120 NC_008024.1 1064725 1065366 R GntR family transcriptional regulator complement(1064725..1065366) Streptococcus pyogenes MGAS10750 4067264 YP_602615.1 CDS MGAS10750_Spy1121 NC_008024.1 1065529 1066020 R General stress protein, Gls24 family complement(1065529..1066020) Streptococcus pyogenes MGAS10750 4067265 YP_602616.1 CDS MGAS10750_Spy1122 NC_008024.1 1066028 1066228 R hypothetical protein complement(1066028..1066228) Streptococcus pyogenes MGAS10750 4067266 YP_602617.1 CDS MGAS10750_Spy1123 NC_008024.1 1066269 1066808 R General stress protein, Gls24 family complement(1066269..1066808) Streptococcus pyogenes MGAS10750 4067267 YP_602618.1 CDS MGAS10750_Spy1124 NC_008024.1 1066821 1067009 R Small integral membrane protein complement(1066821..1067009) Streptococcus pyogenes MGAS10750 4067268 YP_602619.1 CDS MGAS10750_Spy1125 NC_008024.1 1067020 1067631 R hypothetical protein complement(1067020..1067631) Streptococcus pyogenes MGAS10750 4067269 YP_602620.1 CDS MGAS10750_Spy1126 NC_008024.1 1067668 1067916 R membrane protein complement(1067668..1067916) Streptococcus pyogenes MGAS10750 4067270 YP_602621.1 CDS pcrA NC_008024.1 1068280 1070598 R DNA helicase II complement(1068280..1070598) Streptococcus pyogenes MGAS10750 4067271 YP_602622.1 CDS MGAS10750_Spy1129 NC_008024.1 1070967 1071137 R hypothetical protein complement(1070967..1071137) Streptococcus pyogenes MGAS10750 4067272 YP_602623.1 CDS MGAS10750_Spy1128 NC_008024.1 1071128 1072450 D Na(+)-linked D-alanine glycine permease 1071128..1072450 Streptococcus pyogenes MGAS10750 4067273 YP_602624.1 CDS MGAS10750_Spy1130 NC_008024.1 1072570 1073805 D Cobalt-zinc-cadmium resistance protein czcD 1072570..1073805 Streptococcus pyogenes MGAS10750 4067274 YP_602625.1 CDS cfa NC_008024.1 1074175 1074948 R cAMP factor complement(1074175..1074948) Streptococcus pyogenes MGAS10750 4067275 YP_602626.1 CDS MGAS10750_Spy1132 NC_008024.1 1075316 1076152 R histidine-binding protein complement(1075316..1076152) Streptococcus pyogenes MGAS10750 4067276 YP_602627.1 CDS MGAS10750_Spy1133 NC_008024.1 1076168 1076797 R histidine transport ATP-binding protein hisP complement(1076168..1076797) Streptococcus pyogenes MGAS10750 4067145 YP_602628.1 CDS MGAS10750_Spy1134 NC_008024.1 1076807 1077448 R histidine transport system permease hisM complement(1076807..1077448) Streptococcus pyogenes MGAS10750 4067146 YP_602629.1 CDS MGAS10750_Spy1135 NC_008024.1 1077555 1077890 R PhnA protein complement(1077555..1077890) Streptococcus pyogenes MGAS10750 4067147 YP_602630.1 CDS glmS NC_008024.1 1078086 1079900 R Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase complement(1078086..1079900) Streptococcus pyogenes MGAS10750 4067148 YP_602631.1 CDS sipC NC_008024.1 1080076 1080633 R Signal peptidase I complement(1080076..1080633) Streptococcus pyogenes MGAS10750 4067149 YP_602632.1 CDS pyk NC_008024.1 1080851 1082353 R catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase complement(1080851..1082353) Streptococcus pyogenes MGAS10750 4067150 YP_602633.1 CDS pfk NC_008024.1 1082416 1083429 R catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase complement(1082416..1083429) Streptococcus pyogenes MGAS10750 4067151 YP_602634.1 CDS dnaE NC_008024.1 1083509 1086619 R Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria.; DNA polymerase III DnaE complement(1083509..1086619) Streptococcus pyogenes MGAS10750 4067152 YP_602635.1 CDS MGAS10750_Spy1141 NC_008024.1 1086714 1087175 D GntR family transcriptional regulator 1086714..1087175 Streptococcus pyogenes MGAS10750 4067153 YP_602636.1 CDS MGAS10750_Spy1142 NC_008024.1 1087175 1087873 D ABC transporter ATP-binding protein 1087175..1087873 Streptococcus pyogenes MGAS10750 4067154 YP_602637.1 CDS MGAS10750_Spy1143 NC_008024.1 1087883 1088668 D ABC transporter permease 1087883..1088668 Streptococcus pyogenes MGAS10750 4067155 YP_602638.1 CDS MGAS10750_Spy1144 NC_008024.1 1088795 1089409 R membrane-associated alkaline phosphatase complement(1088795..1089409) Streptococcus pyogenes MGAS10750 4067156 YP_602639.1 CDS MGAS10750_Spy1145 NC_008024.1 1089919 1090032 D phage protein 1089919..1090032 Streptococcus pyogenes MGAS10750 4067157 YP_602640.1 CDS MGAS10750_Spy1146 NC_008024.1 1090150 1090770 D phage protein 1090150..1090770 Streptococcus pyogenes MGAS10750 4067158 YP_602641.1 CDS glgP NC_008024.1 1091027 1093291 R maltodextrin phosphorylase complement(1091027..1093291) Streptococcus pyogenes MGAS10750 4067159 YP_602642.1 CDS malM NC_008024.1 1093326 1094819 R amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase complement(1093326..1094819) Streptococcus pyogenes MGAS10750 4067160 YP_602643.1 CDS malR NC_008024.1 1094934 1096028 R LacI family transcriptional regulator complement(1094934..1096028) Streptococcus pyogenes MGAS10750 4067161 YP_602644.1 CDS malE NC_008024.1 1096197 1097444 D maltose/maltodextrin-binding protein 1096197..1097444 Streptococcus pyogenes MGAS10750 4067162 YP_602645.1 CDS malF NC_008024.1 1097718 1099079 D sugar ABC transporter permease 1097718..1099079 Streptococcus pyogenes MGAS10750 4067163 YP_602646.1 CDS malG NC_008024.1 1099079 1099915 D sugar ABC transporter permease 1099079..1099915 Streptococcus pyogenes MGAS10750 4067164 YP_602647.1 CDS MGAS10750_Spy1153 NC_008024.1 1100070 1100870 D LacI family transcriptional regulator 1100070..1100870 Streptococcus pyogenes MGAS10750 4066692 YP_602648.1 CDS malA NC_008024.1 1100986 1101801 R maltodextrose utilization protein malA complement(1100986..1101801) Streptococcus pyogenes MGAS10750 4066693 YP_602649.1 CDS malD NC_008024.1 1101823 1102683 R maltodextrin transport system permease malD complement(1101823..1102683) Streptococcus pyogenes MGAS10750 4066694 YP_602650.1 CDS malC NC_008024.1 1102680 1103987 R maltodextrin transport system permease malC complement(1102680..1103987) Streptococcus pyogenes MGAS10750 4066695 YP_602651.1 CDS MGAS10750_Spy1157 NC_008024.1 1104062 1104796 R Cyclodextrin glucanotransferase complement(1104062..1104796) Streptococcus pyogenes MGAS10750 4066696 YP_602652.1 CDS amyA NC_008024.1 1104750 1106198 R Cyclodextrin glucanotransferase complement(1104750..1106198) Streptococcus pyogenes MGAS10750 4066697 YP_602653.1 CDS amyB NC_008024.1 1106224 1107939 R multifunctional; Neopullulanase / Cyclomaltodextrinase / maltogenic alpha-amylase complement(1106224..1107939) Streptococcus pyogenes MGAS10750 4066698 YP_602654.1 CDS malX NC_008024.1 1108093 1109388 R maltose/maltodextrin-binding protein complement(1108093..1109388) Streptococcus pyogenes MGAS10750 4066699 YP_602655.1 CDS MGAS10750_Spy1161 NC_008024.1 1109683 1109907 D transposase 1109683..1109907 Streptococcus pyogenes MGAS10750 4066700 YP_602656.1 CDS MGAS10750_Spy1162 NC_008024.1 1109972 1110955 R Esterase complement(1109972..1110955) Streptococcus pyogenes MGAS10750 4066701 YP_602657.1 CDS dltD NC_008024.1 1110986 1112236 R protein dltD precursor complement(1110986..1112236) Streptococcus pyogenes MGAS10750 4066702 YP_602658.1 CDS MGAS10750_Spy1164 NC_008024.1 1112229 1112468 R D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 2 complement(1112229..1112468) Streptococcus pyogenes MGAS10750 4066703 YP_602659.1 CDS MGAS10750_Spy1165 NC_008024.1 1112486 1113742 R protein dltB complement(1112486..1113742) Streptococcus pyogenes MGAS10750 4066704 YP_602660.1 CDS dltA NC_008024.1 1113739 1115277 R transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 1 complement(1113739..1115277) Streptococcus pyogenes MGAS10750 4066705 YP_602661.1 CDS MGAS10750_Spy1167 NC_008024.1 1115289 1115432 R hypothetical protein complement(1115289..1115432) Streptococcus pyogenes MGAS10750 4066706 YP_602662.1 CDS uvrB NC_008024.1 1115697 1117688 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B complement(1115697..1117688) Streptococcus pyogenes MGAS10750 4066707 YP_602663.1 CDS glnH NC_008024.1 1117880 1120054 D glutamine-binding protein / glutamine transport system permease glnP 1117880..1120054 Streptococcus pyogenes MGAS10750 4066708 YP_602664.1 CDS glnQ2 NC_008024.1 1120054 1120794 D glutamine transport ATP-binding protein glnQ 1120054..1120794 Streptococcus pyogenes MGAS10750 4066709 YP_602665.1 CDS MGAS10750_Spy1171 NC_008024.1 1120942 1121094 R hypothetical protein complement(1120942..1121094) Streptococcus pyogenes MGAS10750 4066710 YP_602666.1 CDS MGAS10750_Spy1172 NC_008024.1 1121091 1122470 R PTS system, cellobiose-specific IIC component complement(1121091..1122470) Streptococcus pyogenes MGAS10750 4066634 YP_602667.1 CDS MGAS10750_Spy1173 NC_008024.1 1122648 1123097 R hypothetical protein complement(1122648..1123097) Streptococcus pyogenes MGAS10750 4066635 YP_602668.1 CDS MGAS10750_Spy1174 NC_008024.1 1123094 1123429 R PTS system, cellobiose-specific IIA component complement(1123094..1123429) Streptococcus pyogenes MGAS10750 4066636 YP_602669.1 CDS MGAS10750_Spy1175 NC_008024.1 1123432 1123773 R PTS system, cellobiose-specific IIB component complement(1123432..1123773) Streptococcus pyogenes MGAS10750 4066637 YP_602670.1 CDS MGAS10750_Spy1176 NC_008024.1 1123766 1125760 R transcription antiterminator, BglG family / PTS system, mannitol (Cryptic)-specific IIA component complement(1123766..1125760) Streptococcus pyogenes MGAS10750 4066638 YP_602671.1 CDS MGAS10750_Spy1177 NC_008024.1 1126085 1126960 R outer surface protein complement(1126085..1126960) Streptococcus pyogenes MGAS10750 4066639 YP_602672.1 CDS bglA2 NC_008024.1 1126969 1128393 R beta-glucosidase complement(1126969..1128393) Streptococcus pyogenes MGAS10750 4066640 YP_602673.1 CDS MGAS10750_Spy1179 NC_008024.1 1128582 1129289 D Nicotinamide mononucleotide transporter 1128582..1129289 Streptococcus pyogenes MGAS10750 4066641 YP_602674.1 CDS MGAS10750_Spy1180 NC_008024.1 1129294 1129452 R hypothetical protein complement(1129294..1129452) Streptococcus pyogenes MGAS10750 4066642 YP_602675.2 CDS obgE NC_008024.1 1129521 1130828 R essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE complement(1129521..1130828) Streptococcus pyogenes MGAS10750 4066643 YP_602676.1 CDS MGAS10750_Spy1182 NC_008024.1 1130891 1131019 R hypothetical protein complement(1130891..1131019) Streptococcus pyogenes MGAS10750 4066644 YP_602677.1 CDS MGAS10750_Spy1183 NC_008024.1 1131245 1131778 D transposase 1131245..1131778 Streptococcus pyogenes MGAS10750 4066645 YP_602678.1 CDS MGAS10750_Spy1184 NC_008024.1 1131799 1132344 D transposase 1131799..1132344 Streptococcus pyogenes MGAS10750 4066646 YP_602679.1 CDS MGAS10750_Spy1185 NC_008024.1 1132387 1132605 D transposase 1132387..1132605 Streptococcus pyogenes MGAS10750 4066647 YP_602680.1 CDS nadC NC_008024.1 1132905 1133804 R catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase complement(1132905..1133804) Streptococcus pyogenes MGAS10750 4066648 YP_602681.1 CDS MGAS10750_Spy1187 NC_008024.1 1134001 1135311 D transporter 1134001..1135311 Streptococcus pyogenes MGAS10750 4066649 YP_602682.1 CDS MGAS10750_Spy1188 NC_008024.1 1135389 1135682 D transposase 1135389..1135682 Streptococcus pyogenes MGAS10750 4066650 YP_602683.1 CDS MGAS10750_Spy1189 NC_008024.1 1135715 1136068 D transposase 1135715..1136068 Streptococcus pyogenes MGAS10750 4066651 YP_602684.1 CDS MGAS10750_Spy1190 NC_008024.1 1136114 1136437 D transposase 1136114..1136437 Streptococcus pyogenes MGAS10750 4066652 YP_602685.1 CDS rsuA NC_008024.1 1136454 1137188 R ribosomal small subunit pseudouridine synthase A complement(1136454..1137188) Streptococcus pyogenes MGAS10750 4066653 YP_602686.1 CDS MGAS10750_Spy1192 NC_008024.1 1137300 1137665 D hypothetical protein 1137300..1137665 Streptococcus pyogenes MGAS10750 4066997 YP_602687.1 CDS MGAS10750_Spy1193 NC_008024.1 1137785 1139005 R transporter MFS superfamily complement(1137785..1139005) Streptococcus pyogenes MGAS10750 4066998 YP_602688.1 CDS MGAS10750_Spy1194 NC_008024.1 1139307 1140863 D hypothetical protein 1139307..1140863 Streptococcus pyogenes MGAS10750 4066999 YP_602689.1 CDS MGAS10750_Spy1195 NC_008024.1 1140968 1141369 R Thioesterase superfamily protein complement(1140968..1141369) Streptococcus pyogenes MGAS10750 4067000 YP_602690.1 CDS MGAS10750_Spy1196 NC_008024.1 1141454 1141966 R phosphorylase, Pnp/Udp family complement(1141454..1141966) Streptococcus pyogenes MGAS10750 4067001 YP_602691.1 CDS MGAS10750_Spy1197 NC_008024.1 1142384 1143775 R 23S rRNA m(5)U 1939 methyltransferase complement(1142384..1143775) Streptococcus pyogenes MGAS10750 4067002 YP_602692.1 CDS MGAS10750_Spy1198 NC_008024.1 1143824 1145275 R LytR family transcriptional regulator complement(1143824..1145275) Streptococcus pyogenes MGAS10750 4067003 YP_602693.1 CDS aroK NC_008024.1 1145483 1145974 R catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase complement(1145483..1145974) Streptococcus pyogenes MGAS10750 4067004 YP_602694.1 CDS MGAS10750_Spy1200 NC_008024.1 1145967 1147250 R catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase complement(1145967..1147250) Streptococcus pyogenes MGAS10750 4067005 YP_602695.1 CDS MGAS10750_Spy1201 NC_008024.1 1147361 1148326 R ribonuclease BN complement(1147361..1148326) Streptococcus pyogenes MGAS10750 4067006 YP_602696.1 CDS map NC_008024.1 1148328 1149188 R catalyzes the removal of N-terminal amino acids from peptides and arylamides; methionine aminopeptidase complement(1148328..1149188) Streptococcus pyogenes MGAS10750 4067007 YP_602697.1 CDS MGAS10750_Spy1203 NC_008024.1 1149204 1150499 R Cytosolic protein containing multiple CBS domains complement(1149204..1150499) Streptococcus pyogenes MGAS10750 4067008 YP_602698.1 CDS MGAS10750_Spy1204 NC_008024.1 1150496 1151038 R ribosomal-protein-S5-alanine acetyltransferase complement(1150496..1151038) Streptococcus pyogenes MGAS10750 4067009 YP_602699.1 CDS grab NC_008024.1 1151276 1151929 R protein G-related alpha 2M-binding protein complement(1151276..1151929) Streptococcus pyogenes MGAS10750 4067010 YP_602700.1 CDS murZ NC_008024.1 1152287 1153546 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(1152287..1153546) Streptococcus pyogenes MGAS10750 4067011 YP_602701.1 CDS metK2 NC_008024.1 1153720 1154916 R catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase complement(1153720..1154916) Streptococcus pyogenes MGAS10750 4067012 YP_602702.1 CDS inlA NC_008024.1 1155453 1157765 R Internalin protein complement(1155453..1157765) Streptococcus pyogenes MGAS10750 4067013 YP_602703.1 CDS birA NC_008024.1 1157968 1158909 D catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 1157968..1158909 Streptococcus pyogenes MGAS10750 4067014 YP_602704.1 CDS MGAS10750_Spy1210 NC_008024.1 1158884 1159192 R hypothetical protein complement(1158884..1159192) Streptococcus pyogenes MGAS10750 4067015 YP_602705.1 CDS MGAS10750_Spy1211 NC_008024.1 1159182 1160483 R DNA polymerase III subunit gamma/tau complement(1159182..1160483) Streptococcus pyogenes MGAS10750 4067016 YP_602706.1 CDS MGAS10750_Spy1212 NC_008024.1 1160446 1160853 R DNA polymerase III subunit gamma/tau complement(1160446..1160853) Streptococcus pyogenes MGAS10750 4067017 YP_602707.1 CDS MGAS10750_Spy1213 NC_008024.1 1160853 1161350 R GAF domain-containing protein complement(1160853..1161350) Streptococcus pyogenes MGAS10750 4067018 YP_602708.1 CDS MGAS10750_Spy1214 NC_008024.1 1161495 1162304 D hypothetical protein 1161495..1162304 Streptococcus pyogenes MGAS10750 4067019 YP_602709.1 CDS MGAS10750_Spy1215 NC_008024.1 1162357 1162620 R hypothetical protein complement(1162357..1162620) Streptococcus pyogenes MGAS10750 4067020 YP_602710.1 CDS udk NC_008024.1 1162700 1163338 R functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase complement(1162700..1163338) Streptococcus pyogenes MGAS10750 4067021 YP_602711.1 CDS deaD2 NC_008024.1 1163391 1164509 D ATP-dependent RNA helicase 1163391..1164509 Streptococcus pyogenes MGAS10750 4067022 YP_602712.1 CDS MGAS10750_Spy1218 NC_008024.1 1164531 1165385 R transposase complement(1164531..1165385) Streptococcus pyogenes MGAS10750 4067023 YP_602713.1 CDS MGAS10750_Spy1219 NC_008024.1 1165363 1166022 R transposase complement(1165363..1166022) Streptococcus pyogenes MGAS10750 4067024 YP_602714.1 CDS MGAS10750_Spy1220 NC_008024.1 1166189 1167463 R Peptidoglycan N-acetylglucosamine deacetylase complement(1166189..1167463) Streptococcus pyogenes MGAS10750 4067025 YP_602715.1 CDS gapN NC_008024.1 1167557 1168984 R NADP-dependent glyceraldehyde-3-phosphate dehydrogenase complement(1167557..1168984) Streptococcus pyogenes MGAS10750 4067026 YP_602716.1 CDS pstI NC_008024.1 1169169 1170902 R phosphoenolpyruvate-protein phosphotransferase complement(1169169..1170902) Streptococcus pyogenes MGAS10750 4067027 YP_602717.1 CDS ptsH NC_008024.1 1170907 1171170 R phosphocarrier protein HPr complement(1170907..1171170) Streptococcus pyogenes MGAS10750 4067028 YP_602718.1 CDS MGAS10750_Spy1224 NC_008024.1 1171530 1171655 D glutaredoxin 1171530..1171655 Streptococcus pyogenes MGAS10750 4067029 YP_602719.1 CDS nrdH NC_008024.1 1171678 1171782 D glutaredoxin 1171678..1171782 Streptococcus pyogenes MGAS10750 4067030 YP_602720.1 CDS nrdE2 NC_008024.1 1171802 1173961 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1171802..1173961 Streptococcus pyogenes MGAS10750 4067031 YP_602721.1 CDS MGAS10750_Spy1227 NC_008024.1 1174172 1174297 R hypothetical protein complement(1174172..1174297) Streptococcus pyogenes MGAS10750 4067032 YP_602722.1 CDS nrdF NC_008024.1 1174423 1175382 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 1174423..1175382 Streptococcus pyogenes MGAS10750 4067033 YP_602723.1 CDS MGAS10750_Spy1229 NC_008024.1 1175408 1176217 R transposase complement(1175408..1176217) Streptococcus pyogenes MGAS10750 4067034 YP_602724.1 CDS MGAS10750_Spy1230 NC_008024.1 1176195 1176671 R transposase complement(1176195..1176671) Streptococcus pyogenes MGAS10750 4067035 YP_602725.1 CDS MGAS10750_Spy1231 NC_008024.1 1176650 1176853 R transposase complement(1176650..1176853) Streptococcus pyogenes MGAS10750 4068323 YP_602726.1 CDS MGAS10750_Spy1232 NC_008024.1 1176935 1178227 D chloride channel protein 1176935..1178227 Streptococcus pyogenes MGAS10750 4068324 YP_602727.1 CDS MGAS10750_Spy1233 NC_008024.1 1178323 1178616 D transposase 1178323..1178616 Streptococcus pyogenes MGAS10750 4068325 YP_602728.1 CDS MGAS10750_Spy1234 NC_008024.1 1178649 1178945 D transposase 1178649..1178945 Streptococcus pyogenes MGAS10750 4068326 YP_602729.1 CDS MGAS10750_Spy1235 NC_008024.1 1179048 1179473 D transposase 1179048..1179473 Streptococcus pyogenes MGAS10750 4068327 YP_602730.1 CDS MGAS10750_Spy1236 NC_008024.1 1179570 1180265 R CAAX amino terminal protease family complement(1179570..1180265) Streptococcus pyogenes MGAS10750 4068328 YP_602731.1 CDS MGAS10750_Spy1237 NC_008024.1 1180284 1181045 R hypothetical protein complement(1180284..1181045) Streptococcus pyogenes MGAS10750 4068329 YP_602732.1 CDS MGAS10750_Spy1238 NC_008024.1 1181042 1181272 R Cro/CI family transcriptional regulator complement(1181042..1181272) Streptococcus pyogenes MGAS10750 4068330 YP_602733.1 CDS alaS NC_008024.1 1181617 1184235 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(1181617..1184235) Streptococcus pyogenes MGAS10750 4068331 YP_602734.1 CDS prsA NC_008024.1 1184622 1185677 R cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein; foldase PrsA complement(1184622..1185677) Streptococcus pyogenes MGAS10750 4068332 YP_602735.1 CDS MGAS10750_Spy1241 NC_008024.1 1185740 1186447 R O-methyltransferase complement(1185740..1186447) Streptococcus pyogenes MGAS10750 4068333 YP_602736.1 CDS MGAS10750_Spy1242 NC_008024.1 1186513 1187709 R Permease MFS superfamily complement(1186513..1187709) Streptococcus pyogenes MGAS10750 4068334 YP_602737.1 CDS pepB NC_008024.1 1188085 1189890 R Oligoendopeptidase F complement(1188085..1189890) Streptococcus pyogenes MGAS10750 4068335 YP_602738.1 CDS MGAS10750_Spy1244 NC_008024.1 1189903 1190865 R competence protein/transcription factor complement(1189903..1190865) Streptococcus pyogenes MGAS10750 4068336 YP_602739.1 CDS MGAS10750_Spy1245 NC_008024.1 1191160 1191876 R ribosomal small subunit pseudouridine synthase A complement(1191160..1191876) Streptococcus pyogenes MGAS10750 4068337 YP_602740.1 CDS nagB NC_008024.1 1191995 1192822 R glucosamine-6-phosphate isomerase complement(1191995..1192822) Streptococcus pyogenes MGAS10750 4068338 YP_602741.1 CDS queA NC_008024.1 1192901 1193929 D Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 1192901..1193929 Streptococcus pyogenes MGAS10750 4068339 YP_602742.1 CDS MGAS10750_Spy1248 NC_008024.1 1193936 1195156 D hypothetical protein 1193936..1195156 Streptococcus pyogenes MGAS10750 4068340 YP_602743.1 CDS MGAS10750_Spy1249 NC_008024.1 1195270 1195860 R hypothetical protein complement(1195270..1195860) Streptococcus pyogenes MGAS10750 4068341 YP_602744.1 CDS MGAS10750_Spy1250 NC_008024.1 1195857 1196105 R hypothetical protein complement(1195857..1196105) Streptococcus pyogenes MGAS10750 4066518 YP_602745.1 CDS MGAS10750_Spy1251 NC_008024.1 1196161 1196307 R hypothetical protein complement(1196161..1196307) Streptococcus pyogenes MGAS10750 4066519 YP_602746.1 CDS sodA NC_008024.1 1196474 1197079 R Superoxide dismutase complement(1196474..1197079) Streptococcus pyogenes MGAS10750 4066520 YP_602747.1 CDS holA NC_008024.1 1197176 1198216 R required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta complement(1197176..1198216) Streptococcus pyogenes MGAS10750 4066521 YP_602748.1 CDS comEC NC_008024.1 1198287 1200530 R COME operon protein 3 complement(1198287..1200530) Streptococcus pyogenes MGAS10750 4066522 YP_602749.1 CDS MGAS10750_Spy1255 NC_008024.1 1200511 1201173 R COME operon protein 1 complement(1200511..1201173) Streptococcus pyogenes MGAS10750 4066523 YP_602750.1 CDS MGAS10750_Spy1257 NC_008024.1 1201373 1202191 R 1-acyl-sn-glycerol-3-phosphate acyltransferase complement(1201373..1202191) Streptococcus pyogenes MGAS10750 4066524 YP_602751.1 CDS MGAS10750_Spy1256 NC_008024.1 1202153 1203007 D Methyltransferase 1202153..1203007 Streptococcus pyogenes MGAS10750 4066525 YP_602752.1 CDS MGAS10750_Spy1258 NC_008024.1 1202997 1203275 D hypothetical protein 1202997..1203275 Streptococcus pyogenes MGAS10750 4066526 YP_602753.1 CDS MGAS10750_Spy1259 NC_008024.1 1203299 1204906 R Kup system potassium uptake protein complement(1203299..1204906) Streptococcus pyogenes MGAS10750 4066527 YP_602754.1 CDS MGAS10750_Spy1260 NC_008024.1 1204911 1205195 R Kup system potassium uptake protein complement(1204911..1205195) Streptococcus pyogenes MGAS10750 4066528 YP_602755.1 CDS deaD NC_008024.1 1205428 1207047 R ATP-dependent RNA helicase complement(1205428..1207047) Streptococcus pyogenes MGAS10750 4066529 YP_602756.1 CDS prfC NC_008024.1 1207354 1208898 R stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 complement(1207354..1208898) Streptococcus pyogenes MGAS10750 4066530 YP_602757.1 CDS MGAS10750_Spy1262 NC_008024.1 1208852 1209076 D hypothetical protein 1208852..1209076 Streptococcus pyogenes MGAS10750 4066531 YP_602758.1 CDS MGAS10750_Spy1264 NC_008024.1 1209146 1209841 R hypothetical protein complement(1209146..1209841) Streptococcus pyogenes MGAS10750 4066532 YP_602759.1 CDS murF NC_008024.1 1209921 1211312 R UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase complement(1209921..1211312) Streptococcus pyogenes MGAS10750 4066533 YP_602760.1 CDS ddl NC_008024.1 1211510 1212556 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(1211510..1212556) Streptococcus pyogenes MGAS10750 4066534 YP_602761.1 CDS recR NC_008024.1 1212657 1213352 R involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR complement(1212657..1213352) Streptococcus pyogenes MGAS10750 4066535 YP_602762.1 CDS MGAS10750_Spy1268 NC_008024.1 1213300 1213491 R Penicillin-binding protein complement(1213300..1213491) Streptococcus pyogenes MGAS10750 4066536 YP_602763.1 CDS MGAS10750_Spy1269 NC_008024.1 1214051 1214932 R Formate transporter complement(1214051..1214932) Streptococcus pyogenes MGAS10750 4066537 YP_602764.1 CDS MGAS10750_Spy1270 NC_008024.1 1214954 1215496 R hypothetical protein complement(1214954..1215496) Streptococcus pyogenes MGAS10750 4067694 YP_602765.1 CDS MGAS10750_Spy1271 NC_008024.1 1215657 1216178 R transcriptional regulator, biotin repressor family complement(1215657..1216178) Streptococcus pyogenes MGAS10750 4067695 YP_602766.1 CDS gpmA NC_008024.1 1216286 1216981 R 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase complement(1216286..1216981) Streptococcus pyogenes MGAS10750 4067696 YP_602767.1 CDS pyrD NC_008024.1 1217208 1218155 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; subclass 1A is a dimer formed by two identical PyrD subunits each containing an FMN group; dihydroorotate dehydrogenase 1A 1217208..1218155 Streptococcus pyogenes MGAS10750 4067697 YP_602768.1 CDS MGAS10750_Spy1274 NC_008024.1 1218210 1218383 R hypothetical protein complement(1218210..1218383) Streptococcus pyogenes MGAS10750 4067698 YP_602769.1 CDS MGAS10750_Spy1275 NC_008024.1 1218455 1220317 R Lead, cadmium, zinc and mercury transporting ATPase complement(1218455..1220317) Streptococcus pyogenes MGAS10750 4067699 YP_602770.1 CDS MGAS10750_Spy1276 NC_008024.1 1220848 1221030 R phage protein complement(1220848..1221030) Streptococcus pyogenes MGAS10750 4067700 YP_602771.1 CDS speA2 NC_008024.1 1221143 1221925 R Enterotoxin complement(1221143..1221925) Streptococcus pyogenes MGAS10750 4067701 YP_602772.1 CDS MGAS10750_Spy1278 NC_008024.1 1222173 1223363 R phage protein, Fic family complement(1222173..1223363) Streptococcus pyogenes MGAS10750 4067702 YP_602773.1 CDS MGAS10750_Spy1279 NC_008024.1 1223433 1224650 R phage protein complement(1223433..1224650) Streptococcus pyogenes MGAS10750 4067703 YP_602774.1 CDS MGAS10750_Spy1280 NC_008024.1 1224769 1224996 R Holin complement(1224769..1224996) Streptococcus pyogenes MGAS10750 4067704 YP_602775.1 CDS MGAS10750_Spy1281 NC_008024.1 1224993 1225265 R phage protein complement(1224993..1225265) Streptococcus pyogenes MGAS10750 4067705 YP_602776.1 CDS MGAS10750_Spy1282 NC_008024.1 1225277 1225909 R phage protein complement(1225277..1225909) Streptococcus pyogenes MGAS10750 4067706 YP_602777.1 CDS MGAS10750_Spy1283 NC_008024.1 1225912 1226340 R phage protein complement(1225912..1226340) Streptococcus pyogenes MGAS10750 4067707 YP_602778.1 CDS MGAS10750_Spy1284 NC_008024.1 1226349 1228130 R phage infection protein complement(1226349..1228130) Streptococcus pyogenes MGAS10750 4067708 YP_602779.1 CDS MGAS10750_Spy1285 NC_008024.1 1228145 1229260 R Hyaluronoglucosaminidase complement(1228145..1229260) Streptococcus pyogenes MGAS10750 4067709 YP_602780.1 CDS MGAS10750_Spy1286 NC_008024.1 1229257 1231233 R phage endopeptidase complement(1229257..1231233) Streptococcus pyogenes MGAS10750 4067710 YP_602781.1 CDS MGAS10750_Spy1287 NC_008024.1 1231215 1231910 R phage protein complement(1231215..1231910) Streptococcus pyogenes MGAS10750 4067711 YP_602782.1 CDS MGAS10750_Spy1288 NC_008024.1 1231907 1234264 R phage protein complement(1231907..1234264) Streptococcus pyogenes MGAS10750 4067712 YP_602783.1 CDS MGAS10750_Spy1289 NC_008024.1 1234264 1234635 R phage protein complement(1234264..1234635) Streptococcus pyogenes MGAS10750 4067674 YP_602784.1 CDS MGAS10750_Spy1290 NC_008024.1 1234650 1234913 R phage protein complement(1234650..1234913) Streptococcus pyogenes MGAS10750 4067675 YP_602785.1 CDS MGAS10750_Spy1291 NC_008024.1 1234924 1235505 R Major tail protein complement(1234924..1235505) Streptococcus pyogenes MGAS10750 4067676 YP_602786.1 CDS MGAS10750_Spy1292 NC_008024.1 1235514 1235849 R phage protein complement(1235514..1235849) Streptococcus pyogenes MGAS10750 4067677 YP_602787.1 CDS MGAS10750_Spy1293 NC_008024.1 1235850 1236086 R phage protein complement(1235850..1236086) Streptococcus pyogenes MGAS10750 4067678 YP_602788.1 CDS MGAS10750_Spy1294 NC_008024.1 1236079 1236417 R phage protein complement(1236079..1236417) Streptococcus pyogenes MGAS10750 4067679 YP_602789.1 CDS MGAS10750_Spy1295 NC_008024.1 1236377 1236799 R phage protein complement(1236377..1236799) Streptococcus pyogenes MGAS10750 4067680 YP_602790.1 CDS MGAS10750_Spy1296 NC_008024.1 1236809 1237009 R phage protein complement(1236809..1237009) Streptococcus pyogenes MGAS10750 4067681 YP_602791.1 CDS MGAS10750_Spy1297 NC_008024.1 1237009 1237920 R phage structural protein complement(1237009..1237920) Streptococcus pyogenes MGAS10750 4067682 YP_602792.1 CDS MGAS10750_Spy1298 NC_008024.1 1237945 1238544 R phage protein complement(1237945..1238544) Streptococcus pyogenes MGAS10750 4067683 YP_602793.1 CDS MGAS10750_Spy1299 NC_008024.1 1238486 1239916 R phage terminase complement(1238486..1239916) Streptococcus pyogenes MGAS10750 4067684 YP_602794.1 CDS MGAS10750_Spy1300 NC_008024.1 1240221 1240487 R phage protein complement(1240221..1240487) Streptococcus pyogenes MGAS10750 4067685 YP_602795.1 CDS MGAS10750_Spy1301 NC_008024.1 1240539 1240772 R phage protein complement(1240539..1240772) Streptococcus pyogenes MGAS10750 4067686 YP_602796.1 CDS MGAS10750_Spy1302 NC_008024.1 1240769 1242262 R phage protein complement(1240769..1242262) Streptococcus pyogenes MGAS10750 4067687 YP_602797.1 CDS MGAS10750_Spy1303 NC_008024.1 1242255 1243523 R phage protein complement(1242255..1243523) Streptococcus pyogenes MGAS10750 4067688 YP_602798.1 CDS MGAS10750_Spy1304 NC_008024.1 1243520 1243876 R phage protein complement(1243520..1243876) Streptococcus pyogenes MGAS10750 4067689 YP_602799.1 CDS MGAS10750_Spy1305 NC_008024.1 1244024 1244368 R HNH endonuclease family protein complement(1244024..1244368) Streptococcus pyogenes MGAS10750 4067690 YP_602800.1 CDS MGAS10750_Spy1306 NC_008024.1 1244476 1244895 R phage protein complement(1244476..1244895) Streptococcus pyogenes MGAS10750 4067691 YP_602801.1 CDS MGAS10750_Spy1307 NC_008024.1 1244971 1245222 R phage protein complement(1244971..1245222) Streptococcus pyogenes MGAS10750 4067692 YP_602802.1 CDS MGAS10750_Spy1308 NC_008024.1 1245219 1245374 R phage protein complement(1245219..1245374) Streptococcus pyogenes MGAS10750 4067693 YP_602803.1 CDS MGAS10750_Spy1309 NC_008024.1 1245371 1245688 R phage protein complement(1245371..1245688) Streptococcus pyogenes MGAS10750 4067655 YP_602804.1 CDS MGAS10750_Spy1310 NC_008024.1 1245724 1246236 R phage protein complement(1245724..1246236) Streptococcus pyogenes MGAS10750 4067656 YP_602805.1 CDS MGAS10750_Spy1311 NC_008024.1 1246233 1246565 R phage protein complement(1246233..1246565) Streptococcus pyogenes MGAS10750 4067657 YP_602806.1 CDS MGAS10750_Spy1312 NC_008024.1 1246576 1247922 R phage protein complement(1246576..1247922) Streptococcus pyogenes MGAS10750 4067658 YP_602807.1 CDS MGAS10750_Spy1313 NC_008024.1 1247919 1248314 R phage protein complement(1247919..1248314) Streptococcus pyogenes MGAS10750 4067659 YP_602808.1 CDS MGAS10750_Spy1314 NC_008024.1 1248679 1249476 R phage protein complement(1248679..1249476) Streptococcus pyogenes MGAS10750 4067660 YP_602809.1 CDS MGAS10750_Spy1315 NC_008024.1 1249469 1249669 R phage protein complement(1249469..1249669) Streptococcus pyogenes MGAS10750 4067661 YP_602810.1 CDS MGAS10750_Spy1316 NC_008024.1 1249666 1250223 R RecT protein complement(1249666..1250223) Streptococcus pyogenes MGAS10750 4067662 YP_602811.1 CDS MGAS10750_Spy1317 NC_008024.1 1250267 1250587 R RecT protein complement(1250267..1250587) Streptococcus pyogenes MGAS10750 4067663 YP_602812.1 CDS MGAS10750_Spy1318 NC_008024.1 1250590 1250919 R phage protein complement(1250590..1250919) Streptococcus pyogenes MGAS10750 4067664 YP_602813.1 CDS MGAS10750_Spy1319 NC_008024.1 1250975 1251181 R phage protein complement(1250975..1251181) Streptococcus pyogenes MGAS10750 4067665 YP_602814.1 CDS MGAS10750_Spy1320 NC_008024.1 1251190 1251330 R phage protein complement(1251190..1251330) Streptococcus pyogenes MGAS10750 4067666 YP_602815.1 CDS MGAS10750_Spy1321 NC_008024.1 1251542 1251928 R DNA replication protein dnaD complement(1251542..1251928) Streptococcus pyogenes MGAS10750 4067667 YP_602816.1 CDS MGAS10750_Spy1322 NC_008024.1 1252054 1252308 R phage replication protein complement(1252054..1252308) Streptococcus pyogenes MGAS10750 4067668 YP_602817.1 CDS MGAS10750_Spy1323 NC_008024.1 1252417 1252602 R phage protein complement(1252417..1252602) Streptococcus pyogenes MGAS10750 4067669 YP_602818.1 CDS xis NC_008024.1 1252604 1252915 R Excisionase complement(1252604..1252915) Streptococcus pyogenes MGAS10750 4067670 YP_602819.1 CDS MGAS10750_Spy1325 NC_008024.1 1253185 1253397 R Cro/CI family transcriptional regulator complement(1253185..1253397) Streptococcus pyogenes MGAS10750 4067671 YP_602820.1 CDS MGAS10750_Spy1326 NC_008024.1 1253538 1254353 D Cro/CI family transcriptional regulator 1253538..1254353 Streptococcus pyogenes MGAS10750 4067672 YP_602821.1 CDS MGAS10750_Spy1327 NC_008024.1 1254365 1254883 D phage protein 1254365..1254883 Streptococcus pyogenes MGAS10750 4067673 YP_602822.1 CDS int2 NC_008024.1 1255007 1256149 D DNA integration/recombination/inversion protein 1255007..1256149 Streptococcus pyogenes MGAS10750 4067635 YP_602823.1 CDS MGAS10750_Spy1329 NC_008024.1 1256238 1256513 R DNA-binding protein HU complement(1256238..1256513) Streptococcus pyogenes MGAS10750 4067636 YP_602824.1 CDS MGAS10750_Spy1330 NC_008024.1 1256612 1257199 R hypothetical protein complement(1256612..1257199) Streptococcus pyogenes MGAS10750 4067637 YP_602825.1 CDS MGAS10750_Spy1331 NC_008024.1 1257177 1258037 R Lipase/acylhydrolase with GDSL-like motif complement(1257177..1258037) Streptococcus pyogenes MGAS10750 4067638 YP_602826.1 CDS MGAS10750_Spy1332 NC_008024.1 1258012 1258863 R Fatty acid-binding protein, DegV family complement(1258012..1258863) Streptococcus pyogenes MGAS10750 4067639 YP_602827.1 CDS MGAS10750_Spy1333 NC_008024.1 1259079 1260011 R hypothetical protein complement(1259079..1260011) Streptococcus pyogenes MGAS10750 4067640 YP_602828.1 CDS recN NC_008024.1 1260183 1261142 R DNA repair protein recN complement(1260183..1261142) Streptococcus pyogenes MGAS10750 4067641 YP_602829.1 CDS MGAS10750_Spy1335 NC_008024.1 1261157 1261885 R DNA repair protein recN complement(1261157..1261885) Streptococcus pyogenes MGAS10750 4067642 YP_602830.1 CDS argR1 NC_008024.1 1261864 1262367 R arginine repressor, argR complement(1261864..1262367) Streptococcus pyogenes MGAS10750 4067643 YP_602831.1 CDS MGAS10750_Spy1337 NC_008024.1 1262321 1263148 R Lantibotic precursor complement(1262321..1263148) Streptococcus pyogenes MGAS10750 4067644 YP_602832.1 CDS fps NC_008024.1 1263141 1264013 R bifunctional; Dimethylallyltransferase / Geranyltranstransferase complement(1263141..1264013) Streptococcus pyogenes MGAS10750 4067645 YP_602833.1 CDS xseB NC_008024.1 1264013 1264228 R catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit complement(1264013..1264228) Streptococcus pyogenes MGAS10750 4067646 YP_602834.1 CDS xseA NC_008024.1 1264206 1265561 R bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit complement(1264206..1265561) Streptococcus pyogenes MGAS10750 4067647 YP_602835.1 CDS folD NC_008024.1 1265699 1266559 R catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase complement(1265699..1266559) Streptococcus pyogenes MGAS10750 4067648 YP_602836.1 CDS MGAS10750_Spy1342 NC_008024.1 1266761 1268464 R bifunctional; phosphoglucomutase / phosphomannomutase complement(1266761..1268464) Streptococcus pyogenes MGAS10750 4067649 YP_602837.1 CDS phr NC_008024.1 1268633 1270066 R deoxyribodipyrimidine photolyase complement(1268633..1270066) Streptococcus pyogenes MGAS10750 4067650 YP_602838.1 CDS artP NC_008024.1 1270190 1270927 R arginine transport ATP-binding protein artP complement(1270190..1270927) Streptococcus pyogenes MGAS10750 4067651 YP_602839.1 CDS artQ NC_008024.1 1270924 1271610 R arginine transport system permease artQ complement(1270924..1271610) Streptococcus pyogenes MGAS10750 4067652 YP_602840.1 CDS MGAS10750_Spy1346 NC_008024.1 1271737 1271967 R hypothetical protein complement(1271737..1271967) Streptococcus pyogenes MGAS10750 4067653 YP_602841.1 CDS clpE NC_008024.1 1272264 1274546 D ATP-dependent endopeptidase clp ATP-binding subunit clpE 1272264..1274546 Streptococcus pyogenes MGAS10750 4067654 YP_602842.1 CDS mutT NC_008024.1 1274674 1275129 D Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) 1274674..1275129 Streptococcus pyogenes MGAS10750 4067616 YP_602843.1 CDS MGAS10750_Spy1349 NC_008024.1 1275180 1275482 D hypothetical protein 1275180..1275482 Streptococcus pyogenes MGAS10750 4067617 YP_602844.1 CDS ileS NC_008024.1 1275747 1278548 R IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase complement(1275747..1278548) Streptococcus pyogenes MGAS10750 4067618 YP_602845.1 CDS divIVAS NC_008024.1 1278821 1279579 R cell division initiation protein DivIVA complement(1278821..1279579) Streptococcus pyogenes MGAS10750 4067619 YP_602846.1 CDS MGAS10750_Spy1352 NC_008024.1 1279589 1280380 R RNA binding protein complement(1279589..1280380) Streptococcus pyogenes MGAS10750 4067620 YP_602847.1 CDS MGAS10750_Spy1353 NC_008024.1 1280380 1280634 R membrane protein complement(1280380..1280634) Streptococcus pyogenes MGAS10750 4067621 YP_602848.1 CDS MGAS10750_Spy1354 NC_008024.1 1280639 1281307 R hypothetical protein complement(1280639..1281307) Streptococcus pyogenes MGAS10750 4067622 YP_602849.1 CDS MGAS10750_Spy1355 NC_008024.1 1281307 1281978 R Pyridoxal-5'-phosphate family protein complement(1281307..1281978) Streptococcus pyogenes MGAS10750 4067623 YP_602850.1 CDS ftsZ NC_008024.1 1281981 1283300 R GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ complement(1281981..1283300) Streptococcus pyogenes MGAS10750 4067624 YP_602851.1 CDS ftsA NC_008024.1 1283324 1284688 R cell division protein ftsA complement(1283324..1284688) Streptococcus pyogenes MGAS10750 4067625 YP_602852.1 CDS MGAS10750_Spy1357 NC_008024.1 1284654 1284773 D hypothetical protein 1284654..1284773 Streptococcus pyogenes MGAS10750 4067626 YP_602853.1 CDS divIB NC_008024.1 1284899 1286047 R cell-division initiation protein DivIB complement(1284899..1286047) Streptococcus pyogenes MGAS10750 4067627 YP_602854.1 CDS murG NC_008024.1 1286048 1287151 R UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase complement(1286048..1287151) Streptococcus pyogenes MGAS10750 4067628 YP_602855.1 CDS murD NC_008024.1 1287130 1288488 R UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase complement(1287130..1288488) Streptococcus pyogenes MGAS10750 4067629 YP_602856.1 CDS MGAS10750_Spy1362 NC_008024.1 1288844 1289095 R hypothetical protein complement(1288844..1289095) Streptococcus pyogenes MGAS10750 4067630 YP_602857.1 CDS typA NC_008024.1 1289217 1291058 R GTP-binding protein TypA/BipA complement(1289217..1291058) Streptococcus pyogenes MGAS10750 4067631 YP_602858.1 CDS MGAS10750_Spy1364 NC_008024.1 1291241 1291630 R Rhodanese-related sulfurtransferases complement(1291241..1291630) Streptococcus pyogenes MGAS10750 4067632 YP_602859.1 CDS glcK NC_008024.1 1291640 1292611 R glucokinase complement(1291640..1292611) Streptococcus pyogenes MGAS10750 4067633 YP_602860.1 CDS MGAS10750_Spy1366 NC_008024.1 1292616 1292837 R hypothetical protein complement(1292616..1292837) Streptococcus pyogenes MGAS10750 4067634 YP_602861.1 CDS dpr NC_008024.1 1292960 1293487 R Non-specific DNA-binding protein Dps / Iron-binding ferritin-like antioxidant protein / Ferroxidase complement(1292960..1293487) Streptococcus pyogenes MGAS10750 4067596 YP_602862.1 CDS MGAS10750_Spy1368 NC_008024.1 1293950 1294342 D Type 4 prepilin peptidase pilD 1293950..1294342 Streptococcus pyogenes MGAS10750 4067597 YP_602863.1 CDS MGAS10750_Spy1369 NC_008024.1 1294424 1295503 R 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N complement(1294424..1295503) Streptococcus pyogenes MGAS10750 4067598 YP_602864.1 CDS MGAS10750_Spy1370 NC_008024.1 1295507 1296151 R hypothetical protein complement(1295507..1296151) Streptococcus pyogenes MGAS10750 4067599 YP_602865.1 CDS MGAS10750_Spy1371 NC_008024.1 1296422 1296544 R hypothetical protein complement(1296422..1296544) Streptococcus pyogenes MGAS10750 4067600 YP_602866.1 CDS MGAS10750_Spy1372 NC_008024.1 1296575 1297600 R ribose operon repressor complement(1296575..1297600) Streptococcus pyogenes MGAS10750 4067601 YP_602867.1 CDS MGAS10750_Spy1373 NC_008024.1 1297966 1299003 R ATP-dependent endopeptidase Lon complement(1297966..1299003) Streptococcus pyogenes MGAS10750 4067602 YP_602868.1 CDS coaD NC_008024.1 1298990 1299481 R Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase complement(1298990..1299481) Streptococcus pyogenes MGAS10750 4067603 YP_602869.1 CDS MGAS10750_Spy1375 NC_008024.1 1299471 1300010 R Methyltransferase complement(1299471..1300010) Streptococcus pyogenes MGAS10750 4067604 YP_602870.1 CDS asnA NC_008024.1 1300133 1301125 R catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA complement(1300133..1301125) Streptococcus pyogenes MGAS10750 4067605 YP_602871.1 CDS arcC NC_008024.1 1301438 1302388 R catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase complement(1301438..1302388) Streptococcus pyogenes MGAS10750 4067606 YP_602872.1 CDS MGAS10750_Spy1378 NC_008024.1 1302408 1303739 R hypothetical protein complement(1302408..1303739) Streptococcus pyogenes MGAS10750 4067607 YP_602873.1 CDS MGAS10750_Spy1379 NC_008024.1 1303756 1305249 R arginine/ornithine antiporter complement(1303756..1305249) Streptococcus pyogenes MGAS10750 4067608 YP_602874.1 CDS arcB NC_008024.1 1305419 1306432 R catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase complement(1305419..1306432) Streptococcus pyogenes MGAS10750 4067609 YP_602875.1 CDS MGAS10750_Spy1381 NC_008024.1 1306556 1306897 R acetyltransferase complement(1306556..1306897) Streptococcus pyogenes MGAS10750 4067610 YP_602876.1 CDS arcA NC_008024.1 1306997 1308232 R catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase complement(1306997..1308232) Streptococcus pyogenes MGAS10750 4067611 YP_602877.1 CDS MGAS10750_Spy1383 NC_008024.1 1308506 1309186 R transcription regulator, crp family complement(1308506..1309186) Streptococcus pyogenes MGAS10750 4067612 YP_602878.1 CDS ahrC2 NC_008024.1 1309328 1309801 D arginine repressor, argR 1309328..1309801 Streptococcus pyogenes MGAS10750 4067613 YP_602879.1 CDS MGAS10750_Spy1385 NC_008024.1 1309968 1310684 R hypothetical protein complement(1309968..1310684) Streptococcus pyogenes MGAS10750 4067614 YP_602880.1 CDS MGAS10750_Spy1386 NC_008024.1 1310698 1311777 R hypothetical protein complement(1310698..1311777) Streptococcus pyogenes MGAS10750 4067615 YP_602881.1 CDS MGAS10750_Spy1387 NC_008024.1 1311850 1313583 R two-component sensor kinase yesM complement(1311850..1313583) Streptococcus pyogenes MGAS10750 4067577 YP_602882.1 CDS MGAS10750_Spy1388 NC_008024.1 1313580 1314320 R two-component response regulator yesN complement(1313580..1314320) Streptococcus pyogenes MGAS10750 4067578 YP_602883.1 CDS msrA NC_008024.1 1314408 1315514 R Peptide methionine sulfoxide reductase msrA/msrB complement(1314408..1315514) Streptococcus pyogenes MGAS10750 4067579 YP_602884.1 CDS tlpA NC_008024.1 1315557 1316180 R Thiol:disulfide interchange protein tlpA complement(1315557..1316180) Streptococcus pyogenes MGAS10750 4067580 YP_602885.1 CDS ccdA NC_008024.1 1316193 1316903 R Cytochrome c-type biogenesis protein ccdA complement(1316193..1316903) Streptococcus pyogenes MGAS10750 4067581 YP_602886.1 CDS MGAS10750_Spy1392 NC_008024.1 1317572 1317865 R hypothetical protein complement(1317572..1317865) Streptococcus pyogenes MGAS10750 4067582 YP_602887.1 CDS MGAS10750_Spy1393 NC_008024.1 1317876 1318901 R hypothetical protein complement(1317876..1318901) Streptococcus pyogenes MGAS10750 4067583 YP_602888.1 CDS MGAS10750_Spy1394 NC_008024.1 1318898 1319572 R hypothetical protein complement(1318898..1319572) Streptococcus pyogenes MGAS10750 4067584 YP_602889.1 CDS MGAS10750_Spy1395 NC_008024.1 1319574 1320437 R hypothetical protein complement(1319574..1320437) Streptococcus pyogenes MGAS10750 4067585 YP_602890.1 CDS MGAS10750_Spy1396 NC_008024.1 1320427 1322322 R hypothetical protein complement(1320427..1322322) Streptococcus pyogenes MGAS10750 4067586 YP_602891.1 CDS MGAS10750_Spy1397 NC_008024.1 1322322 1323050 R hypothetical protein complement(1322322..1323050) Streptococcus pyogenes MGAS10750 4067587 YP_602892.1 CDS MGAS10750_Spy1398 NC_008024.1 1323183 1323476 R ATP-dependent RNA helicase complement(1323183..1323476) Streptococcus pyogenes MGAS10750 4067588 YP_602893.1 CDS MGAS10750_Spy1399 NC_008024.1 1323554 1325182 R ATP-dependent RNA helicase complement(1323554..1325182) Streptococcus pyogenes MGAS10750 4067589 YP_602894.1 CDS valS NC_008024.1 1325336 1327984 R valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase complement(1325336..1327984) Streptococcus pyogenes MGAS10750 4067590 YP_602895.1 CDS MGAS10750_Spy1401 NC_008024.1 1327986 1328570 R hypothetical protein complement(1327986..1328570) Streptococcus pyogenes MGAS10750 4067591 YP_602896.1 CDS MGAS10750_Spy1402 NC_008024.1 1328546 1328725 R ribosomal-protein-serineacetyltransferase complement(1328546..1328725) Streptococcus pyogenes MGAS10750 4067592 YP_602897.1 CDS MGAS10750_Spy1403 NC_008024.1 1328895 1329128 D hypothetical protein 1328895..1329128 Streptococcus pyogenes MGAS10750 4067593 YP_602898.1 CDS MGAS10750_Spy1404 NC_008024.1 1329151 1329546 R hypothetical protein complement(1329151..1329546) Streptococcus pyogenes MGAS10750 4067594 YP_602899.1 CDS MGAS10750_Spy1405 NC_008024.1 1329567 1329821 R hypothetical protein complement(1329567..1329821) Streptococcus pyogenes MGAS10750 4067595 YP_602900.1 CDS MGAS10750_Spy1406 NC_008024.1 1330299 1331051 D catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; 3-deoxy-7-phosphoheptulonate synthase 1330299..1331051 Streptococcus pyogenes MGAS10750 4067559 YP_602901.1 CDS aroB NC_008024.1 1331092 1332180 D catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 1331092..1332180 Streptococcus pyogenes MGAS10750 4067560 YP_602902.1 CDS MGAS10750_Spy1408 NC_008024.1 1332450 1332608 R hypothetical protein complement(1332450..1332608) Streptococcus pyogenes MGAS10750 4067561 YP_602903.1 CDS MGAS10750_Spy1409 NC_008024.1 1332616 1332921 R acetate kinase complement(1332616..1332921) Streptococcus pyogenes MGAS10750 4067562 YP_602904.1 CDS MGAS10750_Spy1410 NC_008024.1 1332923 1333261 R hypothetical protein complement(1332923..1333261) Streptococcus pyogenes MGAS10750 4067563 YP_602905.1 CDS MGAS10750_Spy1411 NC_008024.1 1333314 1334069 R SAM-dependent methyltransferase complement(1333314..1334069) Streptococcus pyogenes MGAS10750 4067564 YP_602906.1 CDS aroE NC_008024.1 1334321 1335199 R Shikimate 5-dehydrogenase complement(1334321..1335199) Streptococcus pyogenes MGAS10750 4067565 YP_602907.1 CDS lacZ NC_008024.1 1335337 1338843 R beta-galactosidase complement(1335337..1338843) Streptococcus pyogenes MGAS10750 4067566 YP_602908.1 CDS MGAS10750_Spy1414 NC_008024.1 1338773 1340260 R two-component response regulator yesN complement(1338773..1340260) Streptococcus pyogenes MGAS10750 4067567 YP_602909.1 CDS MGAS10750_Spy1415 NC_008024.1 1340257 1341984 R two-component sensor kinase yesM complement(1340257..1341984) Streptococcus pyogenes MGAS10750 4067568 YP_602910.1 CDS MGAS10750_Spy1416 NC_008024.1 1341971 1342576 R hypothetical protein complement(1341971..1342576) Streptococcus pyogenes MGAS10750 4067569 YP_602911.1 CDS MGAS10750_Spy1417 NC_008024.1 1342882 1344327 R Sugar-binding protein complement(1342882..1344327) Streptococcus pyogenes MGAS10750 4067570 YP_602912.1 CDS MGAS10750_Spy1418 NC_008024.1 1344408 1345334 R sugar ABC transporter permease complement(1344408..1345334) Streptococcus pyogenes MGAS10750 4067571 YP_602913.1 CDS MGAS10750_Spy1419 NC_008024.1 1345344 1346342 R sugar ABC transporter permease complement(1345344..1346342) Streptococcus pyogenes MGAS10750 4067572 YP_602914.1 CDS MGAS10750_Spy1420 NC_008024.1 1346466 1347389 D glucokinase / transcription regulator 1346466..1347389 Streptococcus pyogenes MGAS10750 4067573 YP_602915.1 CDS MGAS10750_Spy1421 NC_008024.1 1347532 1347654 D hypothetical protein 1347532..1347654 Streptococcus pyogenes MGAS10750 4067574 YP_602916.1 CDS MGAS10750_Spy1422 NC_008024.1 1348000 1349442 R beta-glucosidase complement(1348000..1349442) Streptococcus pyogenes MGAS10750 4067575 YP_602917.1 CDS hyl NC_008024.1 1349467 1351161 R Hyaluronoglucosaminidase complement(1349467..1351161) Streptococcus pyogenes MGAS10750 4067576 YP_602918.1 CDS MGAS10750_Spy1424 NC_008024.1 1351212 1352252 R GntR family transcriptional regulator complement(1351212..1352252) Streptococcus pyogenes MGAS10750 4067544 YP_602919.1 CDS MGAS10750_Spy1425 NC_008024.1 1352422 1353672 D hypothetical protein 1352422..1353672 Streptococcus pyogenes MGAS10750 4067545 YP_602920.1 CDS MGAS10750_Spy1426 NC_008024.1 1353687 1356392 D alpha-mannosidase 1353687..1356392 Streptococcus pyogenes MGAS10750 4067546 YP_602921.1 CDS rocA NC_008024.1 1356493 1357848 R Sensory transduction protein kinase complement(1356493..1357848) Streptococcus pyogenes MGAS10750 4067547 YP_602922.1 CDS MGAS10750_Spy1428 NC_008024.1 1358513 1359868 R tRNA (uracil-5-) -methyltransferase complement(1358513..1359868) Streptococcus pyogenes MGAS10750 4067548 YP_602923.1 CDS recX NC_008024.1 1359983 1360759 D binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1359983..1360759 Streptococcus pyogenes MGAS10750 4067549 YP_602924.1 CDS MGAS10750_Spy1430 NC_008024.1 1360839 1361372 D hypothetical protein 1360839..1361372 Streptococcus pyogenes MGAS10750 4067550 YP_602925.1 CDS MGAS10750_Spy1431 NC_008024.1 1361504 1361629 D hypothetical protein 1361504..1361629 Streptococcus pyogenes MGAS10750 4067551 YP_602926.1 CDS MGAS10750_Spy1432 NC_008024.1 1361744 1362130 D transposase 1361744..1362130 Streptococcus pyogenes MGAS10750 4067552 YP_602927.1 CDS MGAS10750_Spy1433 NC_008024.1 1368313 1368537 D hypothetical protein 1368313..1368537 Streptococcus pyogenes MGAS10750 4067537 YP_602928.1 CDS MGAS10750_Spy1434 NC_008024.1 1369131 1369679 R ribosome-associated factor Y complement(1369131..1369679) Streptococcus pyogenes MGAS10750 4067538 YP_602929.1 CDS comFC NC_008024.1 1369759 1370424 R COMF operon protein 3 complement(1369759..1370424) Streptococcus pyogenes MGAS10750 4067539 YP_602930.1 CDS comFA NC_008024.1 1370396 1371721 R COMF operon protein 1 complement(1370396..1371721) Streptococcus pyogenes MGAS10750 4067540 YP_602931.1 CDS MGAS10750_Spy1437 NC_008024.1 1371762 1372409 D Xaa-Pro dipeptidase 1371762..1372409 Streptococcus pyogenes MGAS10750 4067541 YP_602932.1 CDS cysM NC_008024.1 1372537 1373478 D cysteine synthase 1372537..1373478 Streptococcus pyogenes MGAS10750 4067542 YP_602933.1 CDS MGAS10750_Spy1439 NC_008024.1 1373496 1373873 R hypothetical protein complement(1373496..1373873) Streptococcus pyogenes MGAS10750 4067543 YP_602934.1 CDS MGAS10750_Spy1440 NC_008024.1 1373873 1375285 R Peptidyl-prolyl cis-trans isomerase complement(1373873..1375285) Streptococcus pyogenes MGAS10750 4067511 YP_602935.1 CDS yvqC NC_008024.1 1375310 1375957 R two-component response regulator yvqC complement(1375310..1375957) Streptococcus pyogenes MGAS10750 4067512 YP_602936.1 CDS yvqE NC_008024.1 1375944 1376948 R two-component sensor protein yvqE complement(1375944..1376948) Streptococcus pyogenes MGAS10750 4067513 YP_602937.1 CDS yvqF NC_008024.1 1376945 1377688 R transporter yvqF complement(1376945..1377688) Streptococcus pyogenes MGAS10750 4067514 YP_602938.1 CDS MGAS10750_Spy1444 NC_008024.1 1377760 1379658 R Serine/threonine protein kinase complement(1377760..1379658) Streptococcus pyogenes MGAS10750 4067515 YP_602939.1 CDS pppL NC_008024.1 1379655 1380395 R protein phosphatase 2C complement(1379655..1380395) Streptococcus pyogenes MGAS10750 4067516 YP_602940.1 CDS sunL NC_008024.1 1380433 1381755 R 16S rRNA m(5)C 967 methyltransferase complement(1380433..1381755) Streptococcus pyogenes MGAS10750 4067517 YP_602941.1 CDS fmt NC_008024.1 1381745 1382680 R modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase complement(1381745..1382680) Streptococcus pyogenes MGAS10750 4067518 YP_602942.1 CDS priA NC_008024.1 1382742 1385153 R binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA complement(1382742..1385153) Streptococcus pyogenes MGAS10750 4067519 YP_602943.1 CDS MGAS10750_Spy1449 NC_008024.1 1385191 1385508 R Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega complement(1385191..1385508) Streptococcus pyogenes MGAS10750 4067520 YP_602944.1 CDS gmk NC_008024.1 1385524 1386159 R Essential for recycling GMP and indirectly, cGMP; guanylate kinase complement(1385524..1386159) Streptococcus pyogenes MGAS10750 4067521 YP_602945.1 CDS MGAS10750_Spy1451 NC_008024.1 1386269 1387876 R HAD superfamily; hypothetical protein complement(1386269..1387876) Streptococcus pyogenes MGAS10750 4067522 YP_602946.1 CDS MGAS10750_Spy1452 NC_008024.1 1388006 1388995 R LysR family transcriptional regulator complement(1388006..1388995) Streptococcus pyogenes MGAS10750 4067523 YP_602947.1 CDS atoB NC_008024.1 1389101 1390288 D acetyl-CoA acetyltransferase 1389101..1390288 Streptococcus pyogenes MGAS10750 4067524 YP_602948.1 CDS atoD1 NC_008024.1 1390300 1390962 D acetate CoA-transferase alpha subunit 1390300..1390962 Streptococcus pyogenes MGAS10750 4067525 YP_602949.1 CDS atoA NC_008024.1 1390964 1391623 D acetate CoA-transferase beta subunit 1390964..1391623 Streptococcus pyogenes MGAS10750 4067526 YP_602950.1 CDS MGAS10750_Spy1456 NC_008024.1 1391656 1392435 D catalyzes the formation of acetoacetate from 3-hydroxybutyrate; 3-hydroxybutyrate dehydrogenase 1391656..1392435 Streptococcus pyogenes MGAS10750 4067527 YP_602951.1 CDS MGAS10750_Spy1457 NC_008024.1 1392506 1393837 D D-beta-hydroxybutyrate permease 1392506..1393837 Streptococcus pyogenes MGAS10750 4067528 YP_602952.1 CDS luxS NC_008024.1 1393821 1394393 D catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 1393821..1394393 Streptococcus pyogenes MGAS10750 4067529 YP_602953.1 CDS MGAS10750_Spy1459 NC_008024.1 1394538 1396007 R hypothetical protein complement(1394538..1396007) Streptococcus pyogenes MGAS10750 4067530 YP_602954.1 CDS MGAS10750_Spy1460 NC_008024.1 1396021 1397175 R Methyltransferase complement(1396021..1397175) Streptococcus pyogenes MGAS10750 4067492 YP_602955.1 CDS MGAS10750_Spy1461 NC_008024.1 1397620 1397946 R cell division initiation protein DivIVA complement(1397620..1397946) Streptococcus pyogenes MGAS10750 4067493 YP_602956.1 CDS MGAS10750_Spy1462 NC_008024.1 1398068 1398583 R hypothetical protein complement(1398068..1398583) Streptococcus pyogenes MGAS10750 4067494 YP_602957.1 CDS recU NC_008024.1 1398664 1399272 D functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC; Holliday junction-specific endonuclease 1398664..1399272 Streptococcus pyogenes MGAS10750 4067495 YP_602958.1 CDS pbp1A NC_008024.1 1399259 1401424 D Multimodular transpeptidase-transglycosylase PBP 1A 1399259..1401424 Streptococcus pyogenes MGAS10750 4067496 YP_602959.1 CDS pepC NC_008024.1 1401891 1403228 R aminopeptidase C complement(1401891..1403228) Streptococcus pyogenes MGAS10750 4067497 YP_602960.1 CDS nadE NC_008024.1 1403413 1404279 R catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase complement(1403413..1404279) Streptococcus pyogenes MGAS10750 4067498 YP_602961.1 CDS nadE NC_008024.1 1404239 1405693 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase complement(1404239..1405693) Streptococcus pyogenes MGAS10750 4067499 YP_602962.1 CDS MGAS10750_Spy1468 NC_008024.1 1405863 1407254 R amino acid permease complement(1405863..1407254) Streptococcus pyogenes MGAS10750 4067500 YP_602963.1 CDS MGAS10750_Spy1469 NC_008024.1 1407411 1408328 R Thioredoxin reductase complement(1407411..1408328) Streptococcus pyogenes MGAS10750 4067501 YP_602964.1 CDS aapA NC_008024.1 1408392 1408616 R hypothetical protein complement(1408392..1408616) Streptococcus pyogenes MGAS10750 4067502 YP_602965.1 CDS MGAS10750_Spy1471 NC_008024.1 1408720 1409466 R amino acid transport ATP-binding protein complement(1408720..1409466) Streptococcus pyogenes MGAS10750 4067503 YP_602966.1 CDS MGAS10750_Spy1472 NC_008024.1 1409463 1410356 R amino acid ABC transporter permease complement(1409463..1410356) Streptococcus pyogenes MGAS10750 4067504 YP_602967.1 CDS MGAS10750_Spy1474 NC_008024.1 1410460 1411803 R ATP-dependent RNA helicase complement(1410460..1411803) Streptococcus pyogenes MGAS10750 4067505 YP_602968.1 CDS MGAS10750_Spy1473 NC_008024.1 1411802 1411951 D hypothetical protein 1411802..1411951 Streptococcus pyogenes MGAS10750 4067506 YP_602969.1 CDS mraY NC_008024.1 1411961 1412971 R First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase complement(1411961..1412971) Streptococcus pyogenes MGAS10750 4067507 YP_602970.1 CDS MGAS10750_Spy1476 NC_008024.1 1412973 1415228 R Division specific D,D-transpeptidase / cell division protein ftsI complement(1412973..1415228) Streptococcus pyogenes MGAS10750 4067508 YP_602971.1 CDS ftsL NC_008024.1 1415232 1415585 R cell division protein ftsL complement(1415232..1415585) Streptococcus pyogenes MGAS10750 4067509 YP_602972.1 CDS mraW NC_008024.1 1415560 1416573 R S-adenosyl-methyltransferase MraW complement(1415560..1416573) Streptococcus pyogenes MGAS10750 4067510 YP_602973.1 CDS MGAS10750_Spy1479 NC_008024.1 1416809 1417081 R hypothetical protein complement(1416809..1417081) Streptococcus pyogenes MGAS10750 4067472 YP_602974.1 CDS proA NC_008024.1 1417056 1418306 R Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase complement(1417056..1418306) Streptococcus pyogenes MGAS10750 4067473 YP_602975.1 CDS MGAS10750_Spy1481 NC_008024.1 1418299 1419126 R catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase complement(1418299..1419126) Streptococcus pyogenes MGAS10750 4067474 YP_602976.1 CDS proB NC_008024.1 1419184 1420854 R ABC transporter permease complement(1419184..1420854) Streptococcus pyogenes MGAS10750 4067475 YP_602977.1 CDS MGAS10750_Spy1483 NC_008024.1 1420817 1421551 R ABC transporter ATP-binding protein complement(1420817..1421551) Streptococcus pyogenes MGAS10750 4067476 YP_602978.1 CDS MGAS10750_Spy1484 NC_008024.1 1421585 1421851 R hypothetical protein complement(1421585..1421851) Streptococcus pyogenes MGAS10750 4067477 YP_602979.1 CDS tkt NC_008024.1 1422043 1423809 R transketolase complement(1422043..1423809) Streptococcus pyogenes MGAS10750 4067478 YP_602980.1 CDS MGAS10750_Spy1486 NC_008024.1 1423785 1424027 R transketolase complement(1423785..1424027) Streptococcus pyogenes MGAS10750 4067479 YP_602981.1 CDS MGAS10750_Spy1487 NC_008024.1 1424245 1424889 R similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity; translaldolase complement(1424245..1424889) Streptococcus pyogenes MGAS10750 4067480 YP_602982.1 CDS MGAS10750_Spy1488 NC_008024.1 1425011 1426570 R trans-acting positive regulator complement(1425011..1426570) Streptococcus pyogenes MGAS10750 4067481 YP_602983.1 CDS MGAS10750_Spy1489 NC_008024.1 1426500 1427939 R NADH peroxidase complement(1426500..1427939) Streptococcus pyogenes MGAS10750 4067482 YP_602984.1 CDS glpF NC_008024.1 1427955 1428656 R glycerol uptake facilitator protein complement(1427955..1428656) Streptococcus pyogenes MGAS10750 4067483 YP_602985.1 CDS glpO NC_008024.1 1428658 1430496 R alpha-glycerophosphate oxidase complement(1428658..1430496) Streptococcus pyogenes MGAS10750 4067484 YP_602986.1 CDS glpK NC_008024.1 1430512 1432038 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(1430512..1432038) Streptococcus pyogenes MGAS10750 4067485 YP_602987.1 CDS MGAS10750_Spy1493 NC_008024.1 1432399 1432851 R hypothetical protein complement(1432399..1432851) Streptococcus pyogenes MGAS10750 4067486 YP_602988.1 CDS MGAS10750_Spy1494 NC_008024.1 1432918 1433175 R hypothetical protein complement(1432918..1433175) Streptococcus pyogenes MGAS10750 4067487 YP_602989.1 CDS glyS NC_008024.1 1433329 1435368 R glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta complement(1433329..1435368) Streptococcus pyogenes MGAS10750 4067488 YP_602990.1 CDS glyQ NC_008024.1 1435746 1436663 R glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha complement(1435746..1436663) Streptococcus pyogenes MGAS10750 4067489 YP_602991.1 CDS MGAS10750_Spy1497 NC_008024.1 1436627 1436833 R hypothetical protein complement(1436627..1436833) Streptococcus pyogenes MGAS10750 4067490 YP_602992.1 CDS MGAS10750_Spy1498 NC_008024.1 1437035 1437589 R hypothetical protein complement(1437035..1437589) Streptococcus pyogenes MGAS10750 4067491 YP_602993.1 CDS MGAS10750_Spy1499 NC_008024.1 1437700 1438542 R aldo/keto reductase complement(1437700..1438542) Streptococcus pyogenes MGAS10750 4067453 YP_602994.1 CDS nagA NC_008024.1 1438773 1439810 R N-acetylglucosamine-6-phosphate deacetylase complement(1438773..1439810) Streptococcus pyogenes MGAS10750 4067454 YP_602995.1 CDS MGAS10750_Spy1501 NC_008024.1 1439928 1441577 R Sodium-dependent phosphate transporter complement(1439928..1441577) Streptococcus pyogenes MGAS10750 4067455 YP_602996.1 CDS MGAS10750_Spy1503 NC_008024.1 1441617 1441784 R hypothetical protein complement(1441617..1441784) Streptococcus pyogenes MGAS10750 4067456 YP_602997.1 CDS MGAS10750_Spy1502 NC_008024.1 1441761 1442483 D hypothetical protein 1441761..1442483 Streptococcus pyogenes MGAS10750 4067457 YP_602998.1 CDS MGAS10750_Spy1504 NC_008024.1 1442612 1443307 R DegV family protein complement(1442612..1443307) Streptococcus pyogenes MGAS10750 4067458 YP_602999.1 CDS MGAS10750_Spy1505 NC_008024.1 1443742 1444302 D TetR family transcriptional regulator 1443742..1444302 Streptococcus pyogenes MGAS10750 4067459 YP_603000.1 CDS MGAS10750_Spy1506 NC_008024.1 1444338 1445219 R HAD superfamily; hydrolase complement(1444338..1445219) Streptococcus pyogenes MGAS10750 4067460 YP_603001.1 CDS MGAS10750_Spy1507 NC_008024.1 1445164 1445781 R hypothetical protein complement(1445164..1445781) Streptococcus pyogenes MGAS10750 4067461 YP_603002.1 CDS lacD1 NC_008024.1 1445978 1446955 R catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; tagatose 1,6-diphosphate aldolase complement(1445978..1446955) Streptococcus pyogenes MGAS10750 4067462 YP_603003.1 CDS MGAS10750_Spy1509 NC_008024.1 1447105 1447455 R Tagatose-6-phosphate kinase complement(1447105..1447455) Streptococcus pyogenes MGAS10750 4067463 YP_603004.1 CDS lacB1 NC_008024.1 1447465 1447983 R catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; galactose-6-phosphate isomerase subunit LacB complement(1447465..1447983) Streptococcus pyogenes MGAS10750 4067464 YP_603005.1 CDS lacA1 NC_008024.1 1447995 1448420 R catalyzes the interconversion of galactose 6-phosphate to tagatose; galactose-6-phosphate isomerase subunit LacA complement(1447995..1448420) Streptococcus pyogenes MGAS10750 4067465 YP_603006.1 CDS MGAS10750_Spy1512 NC_008024.1 1448677 1450128 R PTS system, galactose-specific IIC component complement(1448677..1450128) Streptococcus pyogenes MGAS10750 4067466 YP_603007.1 CDS MGAS10750_Spy1513 NC_008024.1 1450154 1450459 R PTS system, galactose-specific IIB component complement(1450154..1450459) Streptococcus pyogenes MGAS10750 4067467 YP_603008.1 CDS MGAS10750_Spy1514 NC_008024.1 1450452 1450925 R PTS system, galactose-specific IIA component complement(1450452..1450925) Streptococcus pyogenes MGAS10750 4067468 YP_603009.1 CDS lacR1 NC_008024.1 1451162 1451932 D Lactose phosphotransferase system repressor 1451162..1451932 Streptococcus pyogenes MGAS10750 4067469 YP_603010.1 CDS MGAS10750_Spy1516 NC_008024.1 1451959 1452129 R Copper chaperone complement(1451959..1452129) Streptococcus pyogenes MGAS10750 4067470 YP_603011.1 CDS copZ NC_008024.1 1452136 1452339 R Copper chaperone copZ complement(1452136..1452339) Streptococcus pyogenes MGAS10750 4067471 YP_603012.1 CDS copA NC_008024.1 1452353 1454584 R Copper-exporting ATPase complement(1452353..1454584) Streptococcus pyogenes MGAS10750 4067434 YP_603013.1 CDS copY NC_008024.1 1454584 1455024 R CopAB ATPase metal-fist type repressor complement(1454584..1455024) Streptococcus pyogenes MGAS10750 4067435 YP_603014.1 CDS MGAS10750_Spy1520 NC_008024.1 1455184 1456185 D Esterase 1455184..1456185 Streptococcus pyogenes MGAS10750 4067436 YP_603015.1 CDS rbfA NC_008024.1 1456238 1456594 R associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A complement(1456238..1456594) Streptococcus pyogenes MGAS10750 4067437 YP_603016.1 CDS infB NC_008024.1 1456794 1459655 R Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 complement(1456794..1459655) Streptococcus pyogenes MGAS10750 4067438 YP_603017.1 CDS MGAS10750_Spy1523 NC_008024.1 1459675 1459977 R hypothetical protein complement(1459675..1459977) Streptococcus pyogenes MGAS10750 4067439 YP_603018.1 CDS MGAS10750_Spy1524 NC_008024.1 1459970 1460269 R hypothetical protein complement(1459970..1460269) Streptococcus pyogenes MGAS10750 4067440 YP_603019.2 CDS nusA NC_008024.1 1460282 1461439 R modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA complement(1460282..1461439) Streptococcus pyogenes MGAS10750 4067441 YP_603020.1 CDS MGAS10750_Spy1526 NC_008024.1 1461614 1462150 R in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein complement(1461614..1462150) Streptococcus pyogenes MGAS10750 4067442 YP_603021.1 CDS trmB NC_008024.1 1462409 1463044 R tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase complement(1462409..1463044) Streptococcus pyogenes MGAS10750 4067444 YP_603022.1 CDS MGAS10750_Spy1528 NC_008024.1 1463044 1463835 R phosphotransferase enzyme family complement(1463044..1463835) Streptococcus pyogenes MGAS10750 4067445 YP_603023.1 CDS MGAS10750_Spy1529 NC_008024.1 1463899 1464933 R protein ecsB complement(1463899..1464933) Streptococcus pyogenes MGAS10750 4067446 YP_603024.1 CDS MGAS10750_Spy1530 NC_008024.1 1464936 1465661 R ABC-type transporter ATP-binding protein ecsA complement(1464936..1465661) Streptococcus pyogenes MGAS10750 4067447 YP_603025.1 CDS hit NC_008024.1 1465733 1466152 D Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) 1465733..1466152 Streptococcus pyogenes MGAS10750 4067448 YP_603026.1 CDS MGAS10750_Spy1532 NC_008024.1 1466149 1466505 D hypothetical protein 1466149..1466505 Streptococcus pyogenes MGAS10750 4067449 YP_603027.1 CDS lytR NC_008024.1 1466616 1467899 R LytR family transcriptional regulator complement(1466616..1467899) Streptococcus pyogenes MGAS10750 4067450 YP_603028.1 CDS MGAS10750_Spy1534 NC_008024.1 1467908 1468432 R acetyltransferase complement(1467908..1468432) Streptococcus pyogenes MGAS10750 4067451 YP_603029.1 CDS MGAS10750_Spy1535 NC_008024.1 1468407 1468868 R ATP/GTP hydrolase complement(1468407..1468868) Streptococcus pyogenes MGAS10750 4067452 YP_603030.1 CDS MGAS10750_Spy1536 NC_008024.1 1469022 1470482 R Guanine-hypoxanthine permease complement(1469022..1470482) Streptococcus pyogenes MGAS10750 4067415 YP_603031.1 CDS MGAS10750_Spy1537 NC_008024.1 1470746 1471558 D HAD superfamily; hydrolase 1470746..1471558 Streptococcus pyogenes MGAS10750 4067416 YP_603032.1 CDS manL NC_008024.1 1471910 1472902 D PTS system, mannose-specific IIAB component 1471910..1472902 Streptococcus pyogenes MGAS10750 4067417 YP_603033.1 CDS manM NC_008024.1 1472991 1473800 D PTS system, mannose-specific IIC component 1472991..1473800 Streptococcus pyogenes MGAS10750 4067418 YP_603034.1 CDS manN NC_008024.1 1473817 1474728 D PTS system, mannose-specific IID component 1473817..1474728 Streptococcus pyogenes MGAS10750 4067419 YP_603035.1 CDS manO NC_008024.1 1474842 1475201 D hypothetical protein 1474842..1475201 Streptococcus pyogenes MGAS10750 4067420 YP_603036.1 CDS serS NC_008024.1 1475593 1476870 D catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1475593..1476870 Streptococcus pyogenes MGAS10750 4067421 YP_603037.1 CDS accD NC_008024.1 1477103 1477873 R catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; these proteins present a shorter N-terminus; acetyl-CoA carboxylase subunit alpha complement(1477103..1477873) Streptococcus pyogenes MGAS10750 4067422 YP_603038.1 CDS accA NC_008024.1 1477870 1478736 R catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta complement(1477870..1478736) Streptococcus pyogenes MGAS10750 4067423 YP_603039.2 CDS accC NC_008024.1 1478745 1480109 R an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit complement(1478745..1480109) Streptococcus pyogenes MGAS10750 4067424 YP_603040.1 CDS fabZ NC_008024.1 1480141 1480563 R in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase complement(1480141..1480563) Streptococcus pyogenes MGAS10750 4067425 YP_603041.1 CDS accB NC_008024.1 1480560 1481075 R composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit complement(1480560..1481075) Streptococcus pyogenes MGAS10750 4067426 YP_603042.1 CDS fabF NC_008024.1 1481077 1482309 R FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II complement(1481077..1482309) Streptococcus pyogenes MGAS10750 4067427 YP_603043.1 CDS fabG NC_008024.1 1482324 1483058 R catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-(acyl-carrier-protein) reductase complement(1482324..1483058) Streptococcus pyogenes MGAS10750 4067428 YP_603044.1 CDS fabD NC_008024.1 1483048 1483992 R Malonyl-CoA-(acyl-carrier-protein) transacylase complement(1483048..1483992) Streptococcus pyogenes MGAS10750 4067429 YP_603045.1 CDS fabK NC_008024.1 1484011 1484637 R acyl-carrier protein; Enoyl- reductase (NADH) complement(1484011..1484637) Streptococcus pyogenes MGAS10750 4067430 YP_603046.1 CDS MGAS10750_Spy1552 NC_008024.1 1484573 1484983 R acyl-carrier protein; Enoyl- reductase (NADH) complement(1484573..1484983) Streptococcus pyogenes MGAS10750 4067431 YP_603047.1 CDS acpP NC_008024.1 1485184 1485408 R carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein complement(1485184..1485408) Streptococcus pyogenes MGAS10750 4067432 YP_603048.1 CDS fabH NC_008024.1 1485469 1486443 R FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-(acyl carrier protein) synthase III complement(1485469..1486443) Streptococcus pyogenes MGAS10750 4067433 YP_603049.1 CDS MGAS10750_Spy1555 NC_008024.1 1486444 1486914 R MarR family transcriptional regulator complement(1486444..1486914) Streptococcus pyogenes MGAS10750 4067395 YP_603050.1 CDS phaB NC_008024.1 1486952 1487743 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(1486952..1487743) Streptococcus pyogenes MGAS10750 4067396 YP_603051.1 CDS dnaJ NC_008024.1 1487963 1489153 R chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ complement(1487963..1489153) Streptococcus pyogenes MGAS10750 4067397 YP_603052.1 CDS dnaK NC_008024.1 1489380 1491206 R heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK complement(1489380..1491206) Streptococcus pyogenes MGAS10750 4067398 YP_603053.1 CDS grpE NC_008024.1 1491387 1491959 R with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE complement(1491387..1491959) Streptococcus pyogenes MGAS10750 4067399 YP_603054.1 CDS hrcA NC_008024.1 1491962 1492996 R Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor complement(1491962..1492996) Streptococcus pyogenes MGAS10750 4067400 YP_603055.1 CDS MGAS10750_Spy1561 NC_008024.1 1493131 1493700 R N-acetylmuramoyl-L-alanine amidase complement(1493131..1493700) Streptococcus pyogenes MGAS10750 4067401 YP_603056.1 CDS MGAS10750_Spy1562 NC_008024.1 1493697 1494440 R D-alanyl-D-alanine metallocarboxypeptidase complement(1493697..1494440) Streptococcus pyogenes MGAS10750 4067402 YP_603057.1 CDS MGAS10750_Spy1563 NC_008024.1 1494430 1495137 R phosphoglycerate mutase family protein complement(1494430..1495137) Streptococcus pyogenes MGAS10750 4067403 YP_603058.1 CDS MGAS10750_Spy1564 NC_008024.1 1495529 1495777 R hypothetical protein complement(1495529..1495777) Streptococcus pyogenes MGAS10750 4067404 YP_603059.1 CDS MGAS10750_Spy1565 NC_008024.1 1495987 1496202 R hypothetical protein complement(1495987..1496202) Streptococcus pyogenes MGAS10750 4067405 YP_603060.1 CDS gatB NC_008024.1 1496199 1497638 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B complement(1496199..1497638) Streptococcus pyogenes MGAS10750 4067406 YP_603061.1 CDS gatA NC_008024.1 1497638 1499104 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A complement(1497638..1499104) Streptococcus pyogenes MGAS10750 4067407 YP_603062.2 CDS gatC NC_008024.1 1499104 1499406 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C complement(1499104..1499406) Streptococcus pyogenes MGAS10750 4067408 YP_603063.1 CDS MGAS10750_Spy1569 NC_008024.1 1499638 1499811 R Pyruvate,phosphate dikinase complement(1499638..1499811) Streptococcus pyogenes MGAS10750 4067409 YP_603064.1 CDS MGAS10750_Spy1570 NC_008024.1 1499819 1499977 R Pyruvate,phosphate dikinase complement(1499819..1499977) Streptococcus pyogenes MGAS10750 4067410 YP_603065.1 CDS MGAS10750_Spy1571 NC_008024.1 1500421 1500978 R bifunctional; Pyrazinamidase / Nicotinamidase complement(1500421..1500978) Streptococcus pyogenes MGAS10750 4067411 YP_603066.1 CDS codY NC_008024.1 1501122 1501904 R CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; transcriptional repressor CodY complement(1501122..1501904) Streptococcus pyogenes MGAS10750 4067412 YP_603067.2 CDS MGAS10750_Spy1573 NC_008024.1 1502121 1503335 R broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT complement(1502121..1503335) Streptococcus pyogenes MGAS10750 4067413 YP_603068.1 CDS MGAS10750_Spy1574 NC_008024.1 1503476 1504018 D Universal stress protein family 1503476..1504018 Streptococcus pyogenes MGAS10750 4067414 YP_603069.1 CDS MGAS10750_Spy1575 NC_008024.1 1504140 1505528 R HAD superfamily; hydrolase complement(1504140..1505528) Streptococcus pyogenes MGAS10750 4067376 YP_603070.1 CDS asnB NC_008024.1 1505600 1506565 D L-asparaginase 1505600..1506565 Streptococcus pyogenes MGAS10750 4067377 YP_603071.1 CDS MGAS10750_Spy1577 NC_008024.1 1506914 1507618 R ABC transporter permease complement(1506914..1507618) Streptococcus pyogenes MGAS10750 4067378 YP_603072.1 CDS MGAS10750_Spy1578 NC_008024.1 1507631 1508533 R ABC transporter ATP-binding protein complement(1507631..1508533) Streptococcus pyogenes MGAS10750 4067379 YP_603073.1 CDS recG NC_008024.1 1508826 1510841 R catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG complement(1508826..1510841) Streptococcus pyogenes MGAS10750 4067380 YP_603074.1 CDS MGAS10750_Spy1580 NC_008024.1 1511216 1512670 R cobalt ABC transporter ATP-binding protein complement(1511216..1512670) Streptococcus pyogenes MGAS10750 4067381 YP_603075.1 CDS MGAS10750_Spy1581 NC_008024.1 1512607 1513287 R Cobalt transport protein cbiQ complement(1512607..1513287) Streptococcus pyogenes MGAS10750 4067382 YP_603076.1 CDS MGAS10750_Spy1582 NC_008024.1 1513284 1513877 R membrane-bound protein complement(1513284..1513877) Streptococcus pyogenes MGAS10750 4067383 YP_603077.1 CDS MGAS10750_Spy1583 NC_008024.1 1513874 1515577 R ABC transporter ATP-binding protein complement(1513874..1515577) Streptococcus pyogenes MGAS10750 4067384 YP_603078.1 CDS MGAS10750_Spy1584 NC_008024.1 1515537 1517300 R ABC transporter ATP-binding protein complement(1515537..1517300) Streptococcus pyogenes MGAS10750 4067385 YP_603079.1 CDS fhuC NC_008024.1 1517297 1518133 R ferrichrome transport ATP-binding protein fhuC complement(1517297..1518133) Streptococcus pyogenes MGAS10750 4067386 YP_603080.1 CDS MGAS10750_Spy1586 NC_008024.1 1518130 1519179 R ferrichrome transport system permease fhuB complement(1518130..1519179) Streptococcus pyogenes MGAS10750 4067387 YP_603081.1 CDS MGAS10750_Spy1587 NC_008024.1 1519154 1520071 R ferrichrome-binding protein complement(1519154..1520071) Streptococcus pyogenes MGAS10750 4067388 YP_603082.1 CDS shp NC_008024.1 1520022 1520897 R hypothetical protein complement(1520022..1520897) Streptococcus pyogenes MGAS10750 4067389 YP_603083.1 CDS MGAS10750_Spy1589 NC_008024.1 1521094 1524927 R Fe3+-siderophore transport protein complement(1521094..1524927) Streptococcus pyogenes MGAS10750 4067390 YP_603084.1 CDS isp2 NC_008024.1 1525413 1526942 R Immunogenic secreted protein complement(1525413..1526942) Streptococcus pyogenes MGAS10750 4067391 YP_603085.1 CDS alr NC_008024.1 1527029 1528129 R converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase complement(1527029..1528129) Streptococcus pyogenes MGAS10750 4067392 YP_603086.1 CDS acpS NC_008024.1 1528126 1528482 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(1528126..1528482) Streptococcus pyogenes MGAS10750 4067393 YP_603087.1 CDS secA NC_008024.1 1528598 1531117 R functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA complement(1528598..1531117) Streptococcus pyogenes MGAS10750 4067394 YP_603088.1 CDS MGAS10750_Spy1594 NC_008024.1 1531195 1531299 R hypothetical protein complement(1531195..1531299) Streptococcus pyogenes MGAS10750 4067356 YP_603089.1 CDS MGAS10750_Spy1595 NC_008024.1 1531283 1532071 R transposase complement(1531283..1532071) Streptococcus pyogenes MGAS10750 4067357 YP_603090.1 CDS MGAS10750_Spy1596 NC_008024.1 1532156 1532356 R transposase complement(1532156..1532356) Streptococcus pyogenes MGAS10750 4067358 YP_603091.1 CDS pmi NC_008024.1 1532508 1533461 R Mannose-6-phosphate isomerase complement(1532508..1533461) Streptococcus pyogenes MGAS10750 4067359 YP_603092.1 CDS scrK NC_008024.1 1533556 1534440 R Fructokinase complement(1533556..1534440) Streptococcus pyogenes MGAS10750 4067360 YP_603093.1 CDS endoS NC_008024.1 1534704 1537772 R endo-beta-N-acetylglucosaminidase F2 precursor complement(1534704..1537772) Streptococcus pyogenes MGAS10750 4067361 YP_603094.1 CDS MGAS10750_Spy1600 NC_008024.1 1537742 1537906 R hypothetical protein complement(1537742..1537906) Streptococcus pyogenes MGAS10750 4067362 YP_603095.1 CDS scrA NC_008024.1 1537949 1539832 R PTS system, sucrose-specific IIABC component complement(1537949..1539832) Streptococcus pyogenes MGAS10750 4067363 YP_603096.1 CDS scrB NC_008024.1 1540071 1541513 D Sucrose-6-phosphate hydrolase 1540071..1541513 Streptococcus pyogenes MGAS10750 4067364 YP_603097.1 CDS scrR NC_008024.1 1541518 1542483 D Sucrose operon repressor 1541518..1542483 Streptococcus pyogenes MGAS10750 4067365 YP_603098.1 CDS nusB NC_008024.1 1542624 1543094 R Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB complement(1542624..1543094) Streptococcus pyogenes MGAS10750 4067366 YP_603099.1 CDS MGAS10750_Spy1605 NC_008024.1 1543069 1543458 R General stress protein, Gls24 family complement(1543069..1543458) Streptococcus pyogenes MGAS10750 4067367 YP_603100.1 CDS efp NC_008024.1 1543504 1544061 R Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P complement(1543504..1544061) Streptococcus pyogenes MGAS10750 4067368 YP_603101.1 CDS comEB NC_008024.1 1544157 1544663 R ComE operon protein 2 complement(1544157..1544663) Streptococcus pyogenes MGAS10750 4067369 YP_603102.1 CDS MGAS10750_Spy1608 NC_008024.1 1544653 1545765 R Xaa-Pro dipeptidase complement(1544653..1545765) Streptococcus pyogenes MGAS10750 4067370 YP_603103.1 CDS uvrA NC_008024.1 1545842 1548700 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A complement(1545842..1548700) Streptococcus pyogenes MGAS10750 4067371 YP_603104.1 CDS corA NC_008024.1 1548873 1549817 D Magnesium and cobalt transport protein corA 1548873..1549817 Streptococcus pyogenes MGAS10750 4067372 YP_603105.1 CDS MGAS10750_Spy1611 NC_008024.1 1549949 1550605 D hypothetical protein 1549949..1550605 Streptococcus pyogenes MGAS10750 4067373 YP_603106.1 CDS rpsR NC_008024.1 1550736 1550975 R binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 complement(1550736..1550975) Streptococcus pyogenes MGAS10750 4067374 YP_603107.1 CDS ssb2 NC_008024.1 1551139 1551630 R binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein complement(1551139..1551630) Streptococcus pyogenes MGAS10750 4067375 YP_603108.1 CDS rpsF NC_008024.1 1551689 1551943 R SSU ribosomal protein S6P complement(1551689..1551943) Streptococcus pyogenes MGAS10750 4068420 YP_603109.1 CDS MGAS10750_Spy1615 NC_008024.1 1552116 1552409 R hypothetical protein complement(1552116..1552409) Streptococcus pyogenes MGAS10750 4068421 YP_603110.1 CDS mutY NC_008024.1 1552577 1553731 D A/G-specific adenine DNA glycosylase 1552577..1553731 Streptococcus pyogenes MGAS10750 4068422 YP_603111.1 CDS MGAS10750_Spy1617 NC_008024.1 1553908 1554495 D transcriptional regulator 1553908..1554495 Streptococcus pyogenes MGAS10750 4068423 YP_603112.1 CDS trx NC_008024.1 1554547 1554903 R Thioredoxin complement(1554547..1554903) Streptococcus pyogenes MGAS10750 4068424 YP_603113.1 CDS MGAS10750_Spy1619 NC_008024.1 1554942 1555445 R phosphatidylglycerophosphatase B complement(1554942..1555445) Streptococcus pyogenes MGAS10750 4068425 YP_603114.1 CDS mutS2 NC_008024.1 1555446 1557902 R DNA mismatch repair protein mutS complement(1555446..1557902) Streptococcus pyogenes MGAS10750 4068426 YP_603115.1 CDS MGAS10750_Spy1621 NC_008024.1 1557934 1558479 R CvpA family membrane protein complement(1557934..1558479) Streptococcus pyogenes MGAS10750 4068427 YP_603116.1 CDS MGAS10750_Spy1622 NC_008024.1 1558482 1558790 R hypothetical protein complement(1558482..1558790) Streptococcus pyogenes MGAS10750 4068428 YP_603117.1 CDS MGAS10750_Spy1623 NC_008024.1 1558947 1559849 D An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease HIII 1558947..1559849 Streptococcus pyogenes MGAS10750 4068429 YP_603118.1 CDS spi NC_008024.1 1559794 1560453 D Signal peptidase I 1559794..1560453 Streptococcus pyogenes MGAS10750 4068430 YP_603119.1 CDS recD NC_008024.1 1560511 1562964 D exodeoxyribonuclease V alpha chain 1560511..1562964 Streptococcus pyogenes MGAS10750 4068431 YP_603120.1 CDS MGAS10750_Spy1626 NC_008024.1 1563055 1563537 D hypothetical protein 1563055..1563537 Streptococcus pyogenes MGAS10750 4068432 YP_603121.1 CDS dinP NC_008024.1 1563630 1564724 R involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV complement(1563630..1564724) Streptococcus pyogenes MGAS10750 4068433 YP_603122.1 CDS pfl NC_008024.1 1564906 1567260 D Formate acetyltransferase 1564906..1567260 Streptococcus pyogenes MGAS10750 4068434 YP_603123.1 CDS MGAS10750_Spy1629 NC_008024.1 1567440 1568390 R beta-lactamase family protein complement(1567440..1568390) Streptococcus pyogenes MGAS10750 4068435 YP_603124.1 CDS MGAS10750_Spy1630 NC_008024.1 1568375 1569127 R hypothetical protein complement(1568375..1569127) Streptococcus pyogenes MGAS10750 4068436 YP_603125.1 CDS MGAS10750_Spy1631 NC_008024.1 1569389 1570321 D hypothetical protein 1569389..1570321 Streptococcus pyogenes MGAS10750 4068437 YP_603126.1 CDS glpF2 NC_008024.1 1570657 1571604 R Aquaporin / glycerol uptake facilitator protein complement(1570657..1571604) Streptococcus pyogenes MGAS10750 4068438 YP_603127.1 CDS norA NC_008024.1 1571977 1573278 R transporter MFS superfamily complement(1571977..1573278) Streptococcus pyogenes MGAS10750 4066769 YP_603128.1 CDS srv NC_008024.1 1573279 1573998 D transcription regulator, crp family 1573279..1573998 Streptococcus pyogenes MGAS10750 4066770 YP_603129.1 CDS pepXP NC_008024.1 1574020 1576302 D catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue; x-prolyl-dipeptidyl aminopeptidase 1574020..1576302 Streptococcus pyogenes MGAS10750 4066771 YP_603130.1 CDS MGAS10750_Spy1636 NC_008024.1 1576382 1576603 R Cro/CI family transcriptional regulator complement(1576382..1576603) Streptococcus pyogenes MGAS10750 4066772 YP_603131.1 CDS MGAS10750_Spy1637 NC_008024.1 1576773 1577147 D transcriptional regulator 1576773..1577147 Streptococcus pyogenes MGAS10750 4066773 YP_603132.1 CDS MGAS10750_Spy1638 NC_008024.1 1577340 1577639 D hypothetical protein 1577340..1577639 Streptococcus pyogenes MGAS10750 4066774 YP_603133.1 CDS MGAS10750_Spy1639 NC_008024.1 1577696 1577989 R MerR family transcriptional regulator complement(1577696..1577989) Streptococcus pyogenes MGAS10750 4066775 YP_603134.1 CDS dnaQ NC_008024.1 1578142 1578768 R 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon complement(1578142..1578768) Streptococcus pyogenes MGAS10750 4066776 YP_603135.1 CDS MGAS10750_Spy1641 NC_008024.1 1578778 1579359 R hypothetical protein complement(1578778..1579359) Streptococcus pyogenes MGAS10750 4066777 YP_603136.1 CDS MGAS10750_Spy1642 NC_008024.1 1579513 1580682 D NAD(FAD)-utilizing dehydrogenases 1579513..1580682 Streptococcus pyogenes MGAS10750 4066778 YP_603137.1 CDS deoC NC_008024.1 1580777 1581448 R catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase complement(1580777..1581448) Streptococcus pyogenes MGAS10750 4066779 YP_603138.1 CDS nupC NC_008024.1 1581478 1582692 R nucleoside permease nupC complement(1581478..1582692) Streptococcus pyogenes MGAS10750 4066780 YP_603139.1 CDS udp NC_008024.1 1582701 1583480 R uridine phosphorylase complement(1582701..1583480) Streptococcus pyogenes MGAS10750 4066781 YP_603140.1 CDS MGAS10750_Spy1646 NC_008024.1 1583545 1583646 R hypothetical protein complement(1583545..1583646) Streptococcus pyogenes MGAS10750 4066782 YP_603141.1 CDS crgR NC_008024.1 1583721 1584479 D GntR family transcriptional regulator 1583721..1584479 Streptococcus pyogenes MGAS10750 4066783 YP_603142.1 CDS rpsN NC_008024.1 1584699 1584968 D located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 1584699..1584968 Streptococcus pyogenes MGAS10750 4066784 YP_603143.1 CDS gcp NC_008024.1 1585139 1586167 R in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease complement(1585139..1586167) Streptococcus pyogenes MGAS10750 4066785 YP_603144.1 CDS MGAS10750_Spy1650 NC_008024.1 1586157 1586612 R ribosomal-protein-S18-alanine acetyltransferase complement(1586157..1586612) Streptococcus pyogenes MGAS10750 4066786 YP_603145.1 CDS MGAS10750_Spy1651 NC_008024.1 1586584 1587315 R Non-proteolytic protein, peptidase family M22 complement(1586584..1587315) Streptococcus pyogenes MGAS10750 4066787 YP_603146.2 CDS MGAS10750_Spy1652 NC_008024.1 1587566 1587796 D hypothetical protein 1587566..1587796 Streptococcus pyogenes MGAS10750 4066788 YP_603147.1 CDS MGAS10750_Spy1653 NC_008024.1 1587798 1589480 D Zn-dependent hydrolase 1587798..1589480 Streptococcus pyogenes MGAS10750 4066750 YP_603148.1 CDS glnA NC_008024.1 1589708 1591054 R glutamine synthetase complement(1589708..1591054) Streptococcus pyogenes MGAS10750 4066751 YP_603149.1 CDS MGAS10750_Spy1655 NC_008024.1 1591092 1591463 R MerR family transcriptional regulator complement(1591092..1591463) Streptococcus pyogenes MGAS10750 4066752 YP_603150.1 CDS MGAS10750_Spy1656 NC_008024.1 1591530 1592081 R hypothetical protein complement(1591530..1592081) Streptococcus pyogenes MGAS10750 4066753 YP_603151.1 CDS pgk NC_008024.1 1592344 1593540 R Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase complement(1592344..1593540) Streptococcus pyogenes MGAS10750 4066754 YP_603152.1 CDS lppC NC_008024.1 1593733 1594587 R Acid phosphatase complement(1593733..1594587) Streptococcus pyogenes MGAS10750 4066755 YP_603153.1 CDS MGAS10750_Spy1659 NC_008024.1 1594817 1595707 R Membrane protease family complement(1594817..1595707) Streptococcus pyogenes MGAS10750 4066756 YP_603154.1 CDS MGAS10750_Spy1660 NC_008024.1 1595944 1597608 R dihydroxyacetone kinase family protein complement(1595944..1597608) Streptococcus pyogenes MGAS10750 4066757 YP_603155.1 CDS asp NC_008024.1 1597608 1597973 R General stress protein, Gls24 family complement(1597608..1597973) Streptococcus pyogenes MGAS10750 4066758 YP_603156.1 CDS rpmB NC_008024.1 1598125 1598313 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(1598125..1598313) Streptococcus pyogenes MGAS10750 4066759 YP_603157.1 CDS fba NC_008024.1 1598695 1599576 R catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase complement(1598695..1599576) Streptococcus pyogenes MGAS10750 4066760 YP_603158.1 CDS MGAS10750_Spy1664 NC_008024.1 1599921 1600847 R alpha/beta hydrolase complement(1599921..1600847) Streptococcus pyogenes MGAS10750 4066762 YP_603159.1 CDS pyrG NC_008024.1 1601015 1602619 R CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase complement(1601015..1602619) Streptococcus pyogenes MGAS10750 4066763 YP_603160.1 CDS rpoE NC_008024.1 1602876 1603484 R participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; DNA-directed RNA polymerase subunit delta complement(1602876..1603484) Streptococcus pyogenes MGAS10750 4066764 YP_603161.1 CDS tig NC_008024.1 1603668 1605038 R Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor complement(1603668..1605038) Streptococcus pyogenes MGAS10750 4066765 YP_603162.1 CDS MGAS10750_Spy1668 NC_008024.1 1605272 1606117 D Mechanosensitive ion channel 1605272..1606117 Streptococcus pyogenes MGAS10750 4066766 YP_603163.1 CDS MGAS10750_Spy1669 NC_008024.1 1606182 1606742 R hypothetical protein complement(1606182..1606742) Streptococcus pyogenes MGAS10750 4066767 YP_603164.1 CDS MGAS10750_Spy1670 NC_008024.1 1606756 1607226 R hypothetical protein complement(1606756..1607226) Streptococcus pyogenes MGAS10750 4066885 YP_603165.1 CDS thiD NC_008024.1 1607216 1607980 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(1607216..1607980) Streptococcus pyogenes MGAS10750 4066886 YP_603166.1 CDS truA NC_008024.1 1607970 1608719 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(1607970..1608719) Streptococcus pyogenes MGAS10750 4066887 YP_603167.1 CDS comX2 NC_008024.1 1608906 1609391 R Competence-specific sigma factor ComX complement(1608906..1609391) Streptococcus pyogenes MGAS10750 4066888 YP_603168.1 CDS MGAS10750_Spy1674 NC_008024.1 1614879 1615013 D hypothetical protein 1614879..1615013 Streptococcus pyogenes MGAS10750 4066895 YP_603169.1 CDS MGAS10750_Spy1675 NC_008024.1 1615175 1616317 R glycerate kinase complement(1615175..1616317) Streptococcus pyogenes MGAS10750 4066896 YP_603170.1 CDS hsdR NC_008024.1 1616598 1619576 D Type I restriction-modification system restriction subunit 1616598..1619576 Streptococcus pyogenes MGAS10750 4066897 YP_603171.1 CDS hsdS NC_008024.1 1619589 1620764 D Type I restriction-modification system specificity subunit 1619589..1620764 Streptococcus pyogenes MGAS10750 4066898 YP_603172.1 CDS MGAS10750_Spy1678 NC_008024.1 1620777 1621568 D Type I restriction-modification system methylation subunit 1620777..1621568 Streptococcus pyogenes MGAS10750 4066789 YP_603173.1 CDS MGAS10750_Spy1679 NC_008024.1 1621728 1622501 D phage protein 1621728..1622501 Streptococcus pyogenes MGAS10750 4066790 YP_603174.1 CDS MGAS10750_Spy1680 NC_008024.1 1622498 1623325 D hypothetical protein 1622498..1623325 Streptococcus pyogenes MGAS10750 4066791 YP_603175.1 CDS MGAS10750_Spy1681 NC_008024.1 1623318 1623803 D hypothetical protein 1623318..1623803 Streptococcus pyogenes MGAS10750 4066792 YP_603176.1 CDS MGAS10750_Spy1682 NC_008024.1 1623800 1624534 D phage antirepressor protein 1623800..1624534 Streptococcus pyogenes MGAS10750 4066793 YP_603177.1 CDS MGAS10750_Spy1683 NC_008024.1 1624512 1626323 D TraG/TraD family 1624512..1626323 Streptococcus pyogenes MGAS10750 4066794 YP_603178.1 CDS MGAS10750_Spy1684 NC_008024.1 1626342 1626617 D hypothetical protein 1626342..1626617 Streptococcus pyogenes MGAS10750 4066795 YP_603179.1 CDS MGAS10750_Spy1685 NC_008024.1 1626808 1627119 D hypothetical protein 1626808..1627119 Streptococcus pyogenes MGAS10750 4066796 YP_603180.1 CDS MGAS10750_Spy1686 NC_008024.1 1627121 1627336 D hypothetical protein 1627121..1627336 Streptococcus pyogenes MGAS10750 4066797 YP_603181.1 CDS MGAS10750_Spy1687 NC_008024.1 1627347 1628210 D hypothetical protein 1627347..1628210 Streptococcus pyogenes MGAS10750 4066798 YP_603182.1 CDS MGAS10750_Spy1688 NC_008024.1 1628220 1628510 D hypothetical protein 1628220..1628510 Streptococcus pyogenes MGAS10750 4066799 YP_603183.1 CDS MGAS10750_Spy1689 NC_008024.1 1628512 1628922 D hypothetical protein 1628512..1628922 Streptococcus pyogenes MGAS10750 4066800 YP_603184.1 CDS MGAS10750_Spy1690 NC_008024.1 1628813 1630831 D TrsE 1628813..1630831 Streptococcus pyogenes MGAS10750 4066801 YP_603185.1 CDS MGAS10750_Spy1691 NC_008024.1 1630788 1631237 D TrsE 1630788..1631237 Streptococcus pyogenes MGAS10750 4066802 YP_603186.1 CDS MGAS10750_Spy1692 NC_008024.1 1631245 1633824 D NlpC/P60 family protein 1631245..1633824 Streptococcus pyogenes MGAS10750 4066803 YP_603187.1 CDS MGAS10750_Spy1693 NC_008024.1 1633839 1634078 D hypothetical protein 1633839..1634078 Streptococcus pyogenes MGAS10750 4066804 YP_603188.1 CDS MGAS10750_Spy1694 NC_008024.1 1634065 1636416 D surface protein 1634065..1636416 Streptococcus pyogenes MGAS10750 4066805 YP_603189.1 CDS MGAS10750_Spy1695 NC_008024.1 1636431 1637300 D hypothetical protein 1636431..1637300 Streptococcus pyogenes MGAS10750 4066806 YP_603190.1 CDS MGAS10750_Spy1696 NC_008024.1 1637352 1639085 D DNA topoisomerase III 1637352..1639085 Streptococcus pyogenes MGAS10750 4066807 YP_603191.1 CDS MGAS10750_Spy1697 NC_008024.1 1639078 1640043 D Type II restriction-modification system methylation subunit 1639078..1640043 Streptococcus pyogenes MGAS10750 4067075 YP_603192.1 CDS MGAS10750_Spy1698 NC_008024.1 1640030 1647673 D SNF2 family; Superfamily II DNA and RNA helicase 1640030..1647673 Streptococcus pyogenes MGAS10750 4067076 YP_603193.1 CDS MGAS10750_Spy1699 NC_008024.1 1647717 1648373 D hypothetical protein 1647717..1648373 Streptococcus pyogenes MGAS10750 4067077 YP_603194.1 CDS MGAS10750_Spy1700 NC_008024.1 1648925 1649557 D TetR family transcriptional regulator 1648925..1649557 Streptococcus pyogenes MGAS10750 4067078 YP_603195.1 CDS MGAS10750_Spy1701 NC_008024.1 1649642 1650523 D Tetronasin resistance ATP-binding protein 1649642..1650523 Streptococcus pyogenes MGAS10750 4067079 YP_603196.1 CDS MGAS10750_Spy1702 NC_008024.1 1650456 1652162 D Tetronasin resistance transmembrane protein 1650456..1652162 Streptococcus pyogenes MGAS10750 4067080 YP_603197.1 CDS MGAS10750_Spy1704 NC_008024.1 1652743 1652949 R hypothetical protein complement(1652743..1652949) Streptococcus pyogenes MGAS10750 4067081 YP_603198.1 CDS MGAS10750_Spy1703 NC_008024.1 1652896 1653627 D rRNA adenine N-6-methyltransferase 1652896..1653627 Streptococcus pyogenes MGAS10750 4067082 YP_603199.1 CDS MGAS10750_Spy1705 NC_008024.1 1653844 1654368 D spectinomycin phosphotransferase 1653844..1654368 Streptococcus pyogenes MGAS10750 4067083 YP_603200.1 CDS MGAS10750_Spy1706 NC_008024.1 1654414 1654803 D Cytidine deaminase 1654414..1654803 Streptococcus pyogenes MGAS10750 4067084 YP_603201.1 CDS MGAS10750_Spy1707 NC_008024.1 1654782 1655486 D Zn-dependent hydrolase 1654782..1655486 Streptococcus pyogenes MGAS10750 4067085 YP_603202.1 CDS MGAS10750_Spy1708 NC_008024.1 1656371 1657465 R Relaxase complement(1656371..1657465) Streptococcus pyogenes MGAS10750 4067086 YP_603203.1 CDS MGAS10750_Spy1709 NC_008024.1 1657466 1659343 R bifunctional; Reverse transcriptase / RNA maturase / endonuclease complement(1657466..1659343) Streptococcus pyogenes MGAS10750 4067087 YP_603204.1 CDS MGAS10750_Spy1710 NC_008024.1 1659807 1660178 R Relaxase complement(1659807..1660178) Streptococcus pyogenes MGAS10750 4067088 YP_603205.1 CDS MGAS10750_Spy1711 NC_008024.1 1660180 1660638 R hypothetical protein complement(1660180..1660638) Streptococcus pyogenes MGAS10750 4067089 YP_603206.1 CDS MGAS10750_Spy1712 NC_008024.1 1660707 1661801 R RhuM complement(1660707..1661801) Streptococcus pyogenes MGAS10750 4067090 YP_603207.1 CDS MGAS10750_Spy1713 NC_008024.1 1662273 1662824 R hypothetical protein complement(1662273..1662824) Streptococcus pyogenes MGAS10750 4067091 YP_603208.1 CDS MGAS10750_Spy1714 NC_008024.1 1662833 1663234 R Cro/CI family transcriptional regulator complement(1662833..1663234) Streptococcus pyogenes MGAS10750 4067092 YP_603209.1 CDS MGAS10750_Spy1715 NC_008024.1 1663384 1663944 D hypothetical protein 1663384..1663944 Streptococcus pyogenes MGAS10750 4067093 YP_603210.1 CDS MGAS10750_Spy1716 NC_008024.1 1664213 1664623 D hypothetical protein 1664213..1664623 Streptococcus pyogenes MGAS10750 4067094 YP_603211.1 CDS MGAS10750_Spy1717 NC_008024.1 1665419 1667092 D Site-specific recombinase 1665419..1667092 Streptococcus pyogenes MGAS10750 4067184 YP_603212.1 CDS MGAS10750_Spy1718 NC_008024.1 1667092 1668762 D Site-specific recombinase 1667092..1668762 Streptococcus pyogenes MGAS10750 4067185 YP_603213.1 CDS MGAS10750_Spy1719 NC_008024.1 1668755 1670248 D Site-specific recombinase 1668755..1670248 Streptococcus pyogenes MGAS10750 4067186 YP_603214.1 CDS hsdM NC_008024.1 1670421 1671224 D Type I restriction-modification system methylation subunit 1670421..1671224 Streptococcus pyogenes MGAS10750 4067187 YP_603215.1 CDS MGAS10750_Spy1721 NC_008024.1 1671605 1671724 D hypothetical protein 1671605..1671724 Streptococcus pyogenes MGAS10750 4067188 YP_603216.1 CDS salR NC_008024.1 1671781 1672386 R transcriptional regulatory protein degU complement(1671781..1672386) Streptococcus pyogenes MGAS10750 4067189 YP_603217.1 CDS MGAS10750_Spy1723 NC_008024.1 1672367 1673929 R Sensory transduction protein kinase complement(1672367..1673929) Streptococcus pyogenes MGAS10750 4067190 YP_603218.1 CDS salY NC_008024.1 1673969 1675876 R ABC transporter permease complement(1673969..1675876) Streptococcus pyogenes MGAS10750 4067191 YP_603219.1 CDS MGAS10750_Spy1725 NC_008024.1 1675878 1676615 R ABC transporter ATP-binding protein complement(1675878..1676615) Streptococcus pyogenes MGAS10750 4067192 YP_603220.1 CDS salX NC_008024.1 1676612 1678780 R lantibiotic processing peptidase / lantibiotic transport permease / lantibiotic transport ATP-binding protein complement(1676612..1678780) Streptococcus pyogenes MGAS10750 4067193 YP_603221.1 CDS salB NC_008024.1 1678734 1681568 R lantibiotic biosynthesis; serine/threoninedehydratase / Lanthionine synthetase complement(1678734..1681568) Streptococcus pyogenes MGAS10750 4067194 YP_603222.1 CDS salA NC_008024.1 1681650 1681805 R lantibiotic salivaricin A complement(1681650..1681805) Streptococcus pyogenes MGAS10750 4067195 YP_603223.2 CDS lacG NC_008024.1 1682308 1683714 R catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase complement(1682308..1683714) Streptococcus pyogenes MGAS10750 4067196 YP_603224.1 CDS lacE NC_008024.1 1683802 1685499 R PTS system, lactose-specific IIBC component complement(1683802..1685499) Streptococcus pyogenes MGAS10750 4067197 YP_603225.1 CDS lacF NC_008024.1 1685499 1685816 R PTS system, lactose-specific IIA component complement(1685499..1685816) Streptococcus pyogenes MGAS10750 4067198 YP_603226.1 CDS lacD2 NC_008024.1 1685840 1686823 R catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; tagatose 1,6-diphosphate aldolase complement(1685840..1686823) Streptococcus pyogenes MGAS10750 4067199 YP_603227.1 CDS lacC2 NC_008024.1 1686827 1687756 R catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP; tagatose-6-phosphate kinase complement(1686827..1687756) Streptococcus pyogenes MGAS10750 4067200 YP_603228.1 CDS lacB2 NC_008024.1 1687804 1688319 R catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; galactose-6-phosphate isomerase subunit LacB complement(1687804..1688319) Streptococcus pyogenes MGAS10750 4067201 YP_603229.1 CDS lacA2 NC_008024.1 1688354 1688782 R catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization; galactose-6-phosphate isomerase subunit LacA complement(1688354..1688782) Streptococcus pyogenes MGAS10750 4067202 YP_603230.1 CDS lacR2 NC_008024.1 1689228 1690001 D Lactose phosphotransferase system repressor 1689228..1690001 Streptococcus pyogenes MGAS10750 4067296 YP_603231.1 CDS MGAS10750_Spy1737 NC_008024.1 1690651 1690938 D DNA-damage-inducible protein J 1690651..1690938 Streptococcus pyogenes MGAS10750 4067297 YP_603232.1 CDS MGAS10750_Spy1738 NC_008024.1 1690928 1691263 D hypothetical protein 1690928..1691263 Streptococcus pyogenes MGAS10750 4067298 YP_603233.1 CDS MGAS10750_Spy1739 NC_008024.1 1691429 1691578 D DNA integration/recombination/inversion protein 1691429..1691578 Streptococcus pyogenes MGAS10750 4067299 YP_603234.1 CDS rpsI NC_008024.1 1691709 1692101 R forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 complement(1691709..1692101) Streptococcus pyogenes MGAS10750 4067300 YP_603235.2 CDS rplM NC_008024.1 1692122 1692568 R in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 complement(1692122..1692568) Streptococcus pyogenes MGAS10750 4067301 YP_603236.1 CDS MGAS10750_Spy1742 NC_008024.1 1692786 1692992 R Cro/CI family transcriptional regulator complement(1692786..1692992) Streptococcus pyogenes MGAS10750 4067302 YP_603237.1 CDS MGAS10750_Spy1743 NC_008024.1 1692989 1693720 R hypothetical protein complement(1692989..1693720) Streptococcus pyogenes MGAS10750 4067303 YP_603238.1 CDS MGAS10750_Spy1744 NC_008024.1 1693823 1694683 R Fatty acid-binding protein, DegV family complement(1693823..1694683) Streptococcus pyogenes MGAS10750 4067304 YP_603239.1 CDS MGAS10750_Spy1745 NC_008024.1 1694780 1695298 R hypothetical protein complement(1694780..1695298) Streptococcus pyogenes MGAS10750 4067305 YP_603240.1 CDS MGAS10750_Spy1746 NC_008024.1 1695302 1696075 R 23S rRNA Gm2251 methyltransferase complement(1695302..1696075) Streptococcus pyogenes MGAS10750 4067306 YP_603241.1 CDS MGAS10750_Spy1747 NC_008024.1 1696095 1696892 R hypothetical protein complement(1696095..1696892) Streptococcus pyogenes MGAS10750 4067307 YP_603242.1 CDS MGAS10750_Spy1748 NC_008024.1 1697088 1697501 R hypothetical protein complement(1697088..1697501) Streptococcus pyogenes MGAS10750 4067308 YP_603243.1 CDS cysS NC_008024.1 1697494 1698837 R catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase complement(1697494..1698837) Streptococcus pyogenes MGAS10750 4067309 YP_603244.1 CDS MGAS10750_Spy1750 NC_008024.1 1698865 1699095 R hypothetical protein complement(1698865..1699095) Streptococcus pyogenes MGAS10750 4067310 YP_603245.1 CDS MGAS10750_Spy1751 NC_008024.1 1699211 1699411 R hypothetical protein complement(1699211..1699411) Streptococcus pyogenes MGAS10750 4067311 YP_603246.1 CDS cysE NC_008024.1 1699438 1700019 R serineacetyltransferase complement(1699438..1700019) Streptococcus pyogenes MGAS10750 4067312 YP_603247.1 CDS MGAS10750_Spy1753 NC_008024.1 1700028 1700780 R hypothetical protein complement(1700028..1700780) Streptococcus pyogenes MGAS10750 4067313 YP_603248.1 CDS MGAS10750_Spy1754 NC_008024.1 1700773 1702905 R polynucleotide phosphorylase/polyadenylase complement(1700773..1702905) Streptococcus pyogenes MGAS10750 4067314 YP_603249.1 CDS MGAS10750_Spy1755 NC_008024.1 1703185 1703916 R similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity; translaldolase complement(1703185..1703916) Streptococcus pyogenes MGAS10750 4067315 YP_603250.1 CDS ulaA NC_008024.1 1703926 1705305 R membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC complement(1703926..1705305) Streptococcus pyogenes MGAS10750 4066827 YP_603251.1 CDS MGAS10750_Spy1757 NC_008024.1 1705332 1705637 R PTS system, IIB component complement(1705332..1705637) Streptococcus pyogenes MGAS10750 4066828 YP_603252.1 CDS MGAS10750_Spy1758 NC_008024.1 1705609 1707771 R transcription antiterminator, BglG family / PTS system, mannitol (Cryptic)-specific IIA component complement(1705609..1707771) Streptococcus pyogenes MGAS10750 4066829 YP_603253.1 CDS MGAS10750_Spy1759 NC_008024.1 1707894 1708037 R hypothetical protein complement(1707894..1708037) Streptococcus pyogenes MGAS10750 4066830 YP_603254.1 CDS rpsO NC_008024.1 1708021 1708290 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(1708021..1708290) Streptococcus pyogenes MGAS10750 4066831 YP_603255.1 CDS MGAS10750_Spy1761 NC_008024.1 1708449 1708604 R hypothetical protein complement(1708449..1708604) Streptococcus pyogenes MGAS10750 4066832 YP_603256.1 CDS MGAS10750_Spy1762 NC_008024.1 1708730 1708987 D transcriptional regulator 1708730..1708987 Streptococcus pyogenes MGAS10750 4066833 YP_603257.1 CDS def NC_008024.1 1709114 1709728 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1709114..1709728 Streptococcus pyogenes MGAS10750 4066834 YP_603258.1 CDS MGAS10750_Spy1764 NC_008024.1 1709762 1710304 R NADPH-dependent FMN reductase family protein complement(1709762..1710304) Streptococcus pyogenes MGAS10750 4066835 YP_603259.1 CDS MGAS10750_Spy1765 NC_008024.1 1710434 1710892 R MarR family transcriptional regulator complement(1710434..1710892) Streptococcus pyogenes MGAS10750 4066836 YP_603260.1 CDS polC NC_008024.1 1710972 1715369 R catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity; DNA polymerase III PolC complement(1710972..1715369) Streptococcus pyogenes MGAS10750 4066837 YP_603261.1 CDS proS NC_008024.1 1715623 1717479 R catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase complement(1715623..1717479) Streptococcus pyogenes MGAS10750 4066838 YP_603262.1 CDS MGAS10750_Spy1768 NC_008024.1 1717677 1718936 R Membrane endopeptidase, M50 family complement(1717677..1718936) Streptococcus pyogenes MGAS10750 4066839 YP_603263.1 CDS cdsA NC_008024.1 1719009 1719785 R phosphatidate cytidylyltransferase complement(1719009..1719785) Streptococcus pyogenes MGAS10750 4066840 YP_603264.1 CDS uppS NC_008024.1 1719815 1720564 R catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase complement(1719815..1720564) Streptococcus pyogenes MGAS10750 4066841 YP_603265.1 CDS yajC NC_008024.1 1720783 1721142 R member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC complement(1720783..1721142) Streptococcus pyogenes MGAS10750 4066842 YP_603266.1 CDS MGAS10750_Spy1772 NC_008024.1 1721258 1721605 R Thioredoxin complement(1721258..1721605) Streptococcus pyogenes MGAS10750 4066843 YP_603267.1 CDS pulA NC_008024.1 1721747 1725271 R Pullulanase complement(1721747..1725271) Streptococcus pyogenes MGAS10750 4066844 YP_603268.1 CDS MGAS10750_Spy1773 NC_008024.1 1725228 1725458 D hypothetical protein 1725228..1725458 Streptococcus pyogenes MGAS10750 4066845 YP_603269.1 CDS dexB NC_008024.1 1725442 1727076 R glucan 1,6-alpha-glucosidase complement(1725442..1727076) Streptococcus pyogenes MGAS10750 4068520 YP_603270.1 CDS msmK NC_008024.1 1727185 1728318 R Multiple sugar transport ATP-binding protein msmK complement(1727185..1728318) Streptococcus pyogenes MGAS10750 4068521 YP_603271.1 CDS lrp NC_008024.1 1728616 1729506 R hypothetical protein complement(1728616..1729506) Streptococcus pyogenes MGAS10750 4068522 YP_603272.1 CDS ska NC_008024.1 1729804 1731126 D Streptokinase 1729804..1731126 Streptococcus pyogenes MGAS10750 4068523 YP_603273.1 CDS MGAS10750_Spy1779 NC_008024.1 1731224 1731667 R hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase complement(1731224..1731667) Streptococcus pyogenes MGAS10750 4068524 YP_603274.1 CDS relA NC_008024.1 1731682 1733913 R bifunctional; GTP pyrophosphokinase / Guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase complement(1731682..1733913) Streptococcus pyogenes MGAS10750 4068525 YP_603275.1 CDS sclA NC_008024.1 1734153 1735331 R Collagen-like surface protein complement(1734153..1735331) Streptococcus pyogenes MGAS10750 4068526 YP_603276.1 CDS MGAS10750_Spy1782 NC_008024.1 1735712 1736194 D has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; flavoprotein NrdI 1735712..1736194 Streptococcus pyogenes MGAS10750 4068527 YP_603277.1 CDS MGAS10750_Spy1783 NC_008024.1 1736589 1737428 R endonuclease/exonuclease/phosphatase family protein complement(1736589..1737428) Streptococcus pyogenes MGAS10750 4068528 YP_603278.1 CDS MGAS10750_Spy1784 NC_008024.1 1737490 1739676 R PTS system, glucose-specific IIABC component complement(1737490..1739676) Streptococcus pyogenes MGAS10750 4068529 YP_603279.1 CDS MGAS10750_Spy1785 NC_008024.1 1740034 1740783 R in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE complement(1740034..1740783) Streptococcus pyogenes MGAS10750 4068530 YP_603280.1 CDS prmA NC_008024.1 1740783 1741736 R methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase complement(1740783..1741736) Streptococcus pyogenes MGAS10750 4068531 YP_603281.1 CDS MGAS10750_Spy1787 NC_008024.1 1741807 1742277 R hypothetical protein complement(1741807..1742277) Streptococcus pyogenes MGAS10750 4068532 YP_603282.1 CDS MGAS10750_Spy1788 NC_008024.1 1742450 1744423 D Amidase family protein 1742450..1744423 Streptococcus pyogenes MGAS10750 4068533 YP_603283.1 CDS MGAS10750_Spy1789 NC_008024.1 1744602 1746365 D bifunctional; Para-aminobenzoate synthetase component I / 4-amino-4-deoxychorismate lyase 1744602..1746365 Streptococcus pyogenes MGAS10750 4068534 YP_603284.1 CDS trpG NC_008024.1 1746398 1746964 D TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 1746398..1746964 Streptococcus pyogenes MGAS10750 4068535 YP_603285.1 CDS MGAS10750_Spy1791 NC_008024.1 1746997 1748265 D recombination factor protein RarA 1746997..1748265 Streptococcus pyogenes MGAS10750 4068536 YP_603286.1 CDS MGAS10750_Spy1792 NC_008024.1 1748722 1749204 D acetyltransferase 1748722..1749204 Streptococcus pyogenes MGAS10750 4068538 YP_603287.1 CDS flaR NC_008024.1 1749259 1749765 D topology modulation protein 1749259..1749765 Streptococcus pyogenes MGAS10750 4066808 YP_603288.1 CDS MGAS10750_Spy1795 NC_008024.1 1749893 1750057 R hypothetical protein complement(1749893..1750057) Streptococcus pyogenes MGAS10750 4066809 YP_603289.1 CDS smeZ NC_008024.1 1750014 1750715 D Enterotoxin 1750014..1750715 Streptococcus pyogenes MGAS10750 4066810 YP_603290.1 CDS MGAS10750_Spy1796 NC_008024.1 1751042 1751266 R hypothetical protein complement(1751042..1751266) Streptococcus pyogenes MGAS10750 4066811 YP_603291.1 CDS dppA NC_008024.1 1751437 1753071 D Dipeptide-binding protein 1751437..1753071 Streptococcus pyogenes MGAS10750 4066812 YP_603292.1 CDS dppB NC_008024.1 1753184 1754161 D peptide ABC transporter permease 1753184..1754161 Streptococcus pyogenes MGAS10750 4066813 YP_603293.1 CDS dppC NC_008024.1 1754158 1754979 D peptide ABC transporter permease 1754158..1754979 Streptococcus pyogenes MGAS10750 4066814 YP_603294.1 CDS dppD NC_008024.1 1754991 1755794 D peptide ABC transporter ATP-binding protein 1754991..1755794 Streptococcus pyogenes MGAS10750 4066815 YP_603295.1 CDS dppE NC_008024.1 1755778 1756404 D peptide ABC transporter ATP-binding protein 1755778..1756404 Streptococcus pyogenes MGAS10750 4066816 YP_603296.1 CDS MGAS10750_Spy1802 NC_008024.1 1756475 1756753 R hypothetical protein complement(1756475..1756753) Streptococcus pyogenes MGAS10750 4066817 YP_603297.1 CDS MGAS10750_Spy1803 NC_008024.1 1756845 1758767 R Streptococcal histidine triad protein complement(1756845..1758767) Streptococcus pyogenes MGAS10750 4066818 YP_603298.1 CDS MGAS10750_Spy1804 NC_008024.1 1758715 1759323 R Streptococcal histidine triad protein complement(1758715..1759323) Streptococcus pyogenes MGAS10750 4066819 YP_603299.1 CDS lmb NC_008024.1 1759336 1760256 R Laminin-binding surface protein complement(1759336..1760256) Streptococcus pyogenes MGAS10750 4066820 YP_603300.1 CDS MGAS10750_Spy1806 NC_008024.1 1760844 1761689 R Fibronectin-binding protein complement(1760844..1761689) Streptococcus pyogenes MGAS10750 4066821 YP_603301.1 CDS scpA NC_008024.1 1761786 1765283 R C5A peptidase precursor complement(1761786..1765283) Streptococcus pyogenes MGAS10750 4066822 YP_603302.1 CDS MGAS10750_Spy1808 NC_008024.1 1765619 1766608 R M protein complement(1765619..1766608) Streptococcus pyogenes MGAS10750 4066823 YP_603303.1 CDS emm1-0 NC_008024.1 1766893 1767948 R M protein complement(1766893..1767948) Streptococcus pyogenes MGAS10750 4066824 YP_603304.1 CDS MGAS10750_Spy1810 NC_008024.1 1768175 1769341 R M protein complement(1768175..1769341) Streptococcus pyogenes MGAS10750 4066825 YP_603305.1 CDS mga NC_008024.1 1769529 1771139 R trans-acting positive regulator Mry complement(1769529..1771139) Streptococcus pyogenes MGAS10750 4066826 YP_603306.1 CDS MGAS10750_Spy1812 NC_008024.1 1771506 1771700 D hypothetical protein 1771506..1771700 Streptococcus pyogenes MGAS10750 4067036 YP_603307.1 CDS MGAS10750_Spy1813 NC_008024.1 1771806 1772057 R Immunogenic protein complement(1771806..1772057) Streptococcus pyogenes MGAS10750 4067037 YP_603308.1 CDS isp NC_008024.1 1772135 1773763 R Immunogenic secreted protein complement(1772135..1773763) Streptococcus pyogenes MGAS10750 4067038 YP_603309.1 CDS ihk NC_008024.1 1773865 1775253 R two-component system histidine kinase complement(1773865..1775253) Streptococcus pyogenes MGAS10750 4067039 YP_603310.1 CDS irr NC_008024.1 1775250 1775903 R two-component response regulator complement(1775250..1775903) Streptococcus pyogenes MGAS10750 4067040 YP_603311.1 CDS MGAS10750_Spy1817 NC_008024.1 1775997 1777214 R ABC transporter permease complement(1775997..1777214) Streptococcus pyogenes MGAS10750 4067041 YP_603312.1 CDS MGAS10750_Spy1818 NC_008024.1 1777227 1777901 R ABC transporter ATP-binding protein complement(1777227..1777901) Streptococcus pyogenes MGAS10750 4067042 YP_603313.1 CDS MGAS10750_Spy1819 NC_008024.1 1777888 1779156 R periplasmic component of efflux system complement(1777888..1779156) Streptococcus pyogenes MGAS10750 4067043 YP_603314.1 CDS MGAS10750_Spy1820 NC_008024.1 1779580 1779864 R hypothetical protein complement(1779580..1779864) Streptococcus pyogenes MGAS10750 4067044 YP_603315.1 CDS MGAS10750_Spy1821 NC_008024.1 1780013 1780309 R hypothetical protein complement(1780013..1780309) Streptococcus pyogenes MGAS10750 4067045 YP_603316.1 CDS MGAS10750_Spy1822 NC_008024.1 1780451 1782382 R Fibronectin-binding protein complement(1780451..1782382) Streptococcus pyogenes MGAS10750 4067046 YP_603317.1 CDS MGAS10750_Spy1823 NC_008024.1 1782562 1785534 R Fibronectin-binding protein complement(1782562..1785534) Streptococcus pyogenes MGAS10750 4067047 YP_603318.1 CDS MGAS10750_Spy1824 NC_008024.1 1785959 1786195 D hypothetical protein 1785959..1786195 Streptococcus pyogenes MGAS10750 4067048 YP_603319.1 CDS MGAS10750_Spy1825 NC_008024.1 1786466 1787419 R cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein; foldase PrsA complement(1786466..1787419) Streptococcus pyogenes MGAS10750 4067049 YP_603320.1 CDS MGAS10750_Spy1826 NC_008024.1 1787451 1787768 R hypothetical protein complement(1787451..1787768) Streptococcus pyogenes MGAS10750 4067050 YP_603321.1 CDS MGAS10750_Spy1827 NC_008024.1 1787875 1788180 R Streptopain precursor complement(1787875..1788180) Streptococcus pyogenes MGAS10750 4067051 YP_603322.1 CDS speB NC_008024.1 1788182 1789378 R Streptopain precursor complement(1788182..1789378) Streptococcus pyogenes MGAS10750 4067052 YP_603323.1 CDS MGAS10750_Spy1829 NC_008024.1 1789650 1789820 R hypothetical protein complement(1789650..1789820) Streptococcus pyogenes MGAS10750 4067053 YP_603324.1 CDS MGAS10750_Spy1830 NC_008024.1 1789904 1790035 D hypothetical protein 1789904..1790035 Streptococcus pyogenes MGAS10750 4067054 YP_603325.1 CDS rgg NC_008024.1 1790319 1791161 D transcriptional regulator 1790319..1791161 Streptococcus pyogenes MGAS10750 4067055 YP_603326.1 CDS spd NC_008024.1 1791402 1792247 R deoxyribonuclease precursor complement(1791402..1792247) Streptococcus pyogenes MGAS10750 4066673 YP_603327.1 CDS MGAS10750_Spy1833 NC_008024.1 1792301 1792429 D hypothetical protein 1792301..1792429 Streptococcus pyogenes MGAS10750 4066674 YP_603328.1 CDS MGAS10750_Spy1834 NC_008024.1 1792581 1793090 D Low temperature requirement C protein 1792581..1793090 Streptococcus pyogenes MGAS10750 4066675 YP_603329.1 CDS gldA NC_008024.1 1793172 1794260 R forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase complement(1793172..1794260) Streptococcus pyogenes MGAS10750 4066676 YP_603330.1 CDS mipB NC_008024.1 1794317 1794985 R similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase complement(1794317..1794985) Streptococcus pyogenes MGAS10750 4066677 YP_603331.1 CDS pflD NC_008024.1 1794998 1797415 R Formate acetyltransferase complement(1794998..1797415) Streptococcus pyogenes MGAS10750 4066678 YP_603332.1 CDS MGAS10750_Spy1838 NC_008024.1 1797626 1798930 R PTS system, cellobiose-specific IIC component complement(1797626..1798930) Streptococcus pyogenes MGAS10750 4066679 YP_603333.1 CDS MGAS10750_Spy1839 NC_008024.1 1798940 1799248 R PTS system, cellobiose-specific IIB component complement(1798940..1799248) Streptococcus pyogenes MGAS10750 4066680 YP_603334.1 CDS MGAS10750_Spy1840 NC_008024.1 1799276 1799596 R PTS system, cellobiose-specific IIA component complement(1799276..1799596) Streptococcus pyogenes MGAS10750 4066681 YP_603335.1 CDS MGAS10750_Spy1841 NC_008024.1 1799883 1800863 R Sorbitol operon regulator complement(1799883..1800863) Streptococcus pyogenes MGAS10750 4066682 YP_603336.1 CDS MGAS10750_Spy1842 NC_008024.1 1800879 1801628 R DeoR family transcriptional regulator complement(1800879..1801628) Streptococcus pyogenes MGAS10750 4066683 YP_603337.1 CDS MGAS10750_Spy1843 NC_008024.1 1801694 1802524 D Pyruvate formate-lyase activating enzyme 1801694..1802524 Streptococcus pyogenes MGAS10750 4066684 YP_603338.1 CDS MGAS10750_Spy1844 NC_008024.1 1802559 1802759 D hypothetical protein 1802559..1802759 Streptococcus pyogenes MGAS10750 4066685 YP_603339.1 CDS secE NC_008024.1 1802761 1802937 R forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE complement(1802761..1802937) Streptococcus pyogenes MGAS10750 4066686 YP_603340.1 CDS rpmG NC_008024.1 1802951 1803103 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 complement(1802951..1803103) Streptococcus pyogenes MGAS10750 4066687 YP_603341.1 CDS pbp2A NC_008024.1 1803152 1805488 R Multimodular transpeptidase-transglycosylase PBP 2A complement(1803152..1805488) Streptococcus pyogenes MGAS10750 4066688 YP_603342.1 CDS MGAS10750_Spy1848 NC_008024.1 1805527 1805907 R translation initiation inhibitor complement(1805527..1805907) Streptococcus pyogenes MGAS10750 4066689 YP_603343.1 CDS MGAS10750_Spy1849 NC_008024.1 1806398 1806589 D hypothetical protein 1806398..1806589 Streptococcus pyogenes MGAS10750 4066690 YP_603344.1 CDS MGAS10750_Spy1850 NC_008024.1 1806483 1807484 D ribosomal large subunit pseudouridine synthase D 1806483..1807484 Streptococcus pyogenes MGAS10750 4066691 YP_603345.1 CDS MGAS10750_Spy1851 NC_008024.1 1807573 1809297 R hypothetical protein complement(1807573..1809297) Streptococcus pyogenes MGAS10750 4067165 YP_603346.1 CDS MGAS10750_Spy1852 NC_008024.1 1809421 1810959 D Dipeptidase 1809421..1810959 Streptococcus pyogenes MGAS10750 4067166 YP_603347.1 CDS MGAS10750_Spy1853 NC_008024.1 1811289 1811591 R MutR family transcriptional regulator complement(1811289..1811591) Streptococcus pyogenes MGAS10750 4067167 YP_603348.1 CDS MGAS10750_Spy1854 NC_008024.1 1811545 1811814 R MutR family transcriptional regulator complement(1811545..1811814) Streptococcus pyogenes MGAS10750 4067168 YP_603349.2 CDS groEL NC_008024.1 1812062 1813693 R 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL complement(1812062..1813693) Streptococcus pyogenes MGAS10750 4067169 YP_603350.2 CDS groES NC_008024.1 1813729 1814019 R 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES complement(1813729..1814019) Streptococcus pyogenes MGAS10750 4067170 YP_603351.1 CDS clpC NC_008024.1 1814197 1816641 R Negative regulator of genetic competence clpC/mecB complement(1814197..1816641) Streptococcus pyogenes MGAS10750 4067171 YP_603352.1 CDS ctsR NC_008024.1 1816641 1817102 R CtsR family transcriptional regulator complement(1816641..1817102) Streptococcus pyogenes MGAS10750 4067172 YP_603353.1 CDS csp NC_008024.1 1817298 1817507 R Cold shock protein complement(1817298..1817507) Streptococcus pyogenes MGAS10750 4067173 YP_603354.1 CDS ahpC NC_008024.1 1818485 1819045 D Peroxiredoxin 1818485..1819045 Streptococcus pyogenes MGAS10750 4067175 YP_603355.1 CDS ahpF NC_008024.1 1819066 1820598 D bifunctional; Peroxiredoxin reductase (NAD(P)H) / NADH oxidase H2O2-forming 1819066..1820598 Streptococcus pyogenes MGAS10750 4067176 YP_603356.1 CDS hutI NC_008024.1 1820656 1821942 R catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway; imidazolonepropionase complement(1820656..1821942) Streptococcus pyogenes MGAS10750 4067177 YP_603357.1 CDS hutU NC_008024.1 1822213 1824243 D catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism; urocanate hydratase 1822213..1824243 Streptococcus pyogenes MGAS10750 4067178 YP_603358.1 CDS MGAS10750_Spy1864 NC_008024.1 1824331 1825230 D glutamate formiminotransferase 1824331..1825230 Streptococcus pyogenes MGAS10750 4067179 YP_603359.1 CDS MGAS10750_Spy1865 NC_008024.1 1825241 1825867 D formiminotetrahydrofolate cyclodeaminase 1825241..1825867 Streptococcus pyogenes MGAS10750 4067180 YP_603360.1 CDS fhs2 NC_008024.1 1825885 1827558 D catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase 1825885..1827558 Streptococcus pyogenes MGAS10750 4067181 YP_603361.1 CDS MGAS10750_Spy1867 NC_008024.1 1827559 1828176 D hypothetical protein 1827559..1828176 Streptococcus pyogenes MGAS10750 4067182 YP_603362.1 CDS MGAS10750_Spy1868 NC_008024.1 1828396 1829739 D amino acid permease 1828396..1829739 Streptococcus pyogenes MGAS10750 4067183 YP_603363.2 CDS hutH NC_008024.1 1829750 1831291 D catalyzes the degradation of histidine to urocanate and ammmonia; histidine ammonia-lyase 1829750..1831291 Streptococcus pyogenes MGAS10750 4067277 YP_603364.1 CDS hutG NC_008024.1 1831469 1832464 D catalyzes the formation of glutamate and formamide from N-formimidoyl-L-glutamate; formimidoylglutamase 1831469..1832464 Streptococcus pyogenes MGAS10750 4067278 YP_603365.1 CDS MGAS10750_Spy1871 NC_008024.1 1832495 1835569 R LuxR family transcriptional regulator complement(1832495..1835569) Streptococcus pyogenes MGAS10750 4067279 YP_603366.1 CDS rpsB NC_008024.1 1835873 1836640 D one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 1835873..1836640 Streptococcus pyogenes MGAS10750 4067280 YP_603367.2 CDS tsf NC_008024.1 1836774 1837814 D EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 1836774..1837814 Streptococcus pyogenes MGAS10750 4067281 YP_603368.1 CDS pepO NC_008024.1 1837980 1839875 R Oligoendopeptidase O complement(1837980..1839875) Streptococcus pyogenes MGAS10750 4067282 YP_603369.1 CDS dexS NC_008024.1 1840083 1841711 R Trehalose-6-phosphate hydrolase complement(1840083..1841711) Streptococcus pyogenes MGAS10750 4067283 YP_603370.1 CDS MGAS10750_Spy1876 NC_008024.1 1841779 1843803 R bifunctional; PTS system, trehalose-specific IIBC component / PTS system, trehalose-specific IIA component complement(1841779..1843803) Streptococcus pyogenes MGAS10750 4067284 YP_603371.1 CDS MGAS10750_Spy1877 NC_008024.1 1844014 1844727 D Trehalose operon transcriptional repressor 1844014..1844727 Streptococcus pyogenes MGAS10750 4067285 YP_603372.1 CDS MGAS10750_Spy1878 NC_008024.1 1845006 1845344 R MarR family transcriptional regulator complement(1845006..1845344) Streptococcus pyogenes MGAS10750 4067286 YP_603373.1 CDS MGAS10750_Spy1879 NC_008024.1 1845530 1846285 D Glyoxalase family protein 1845530..1846285 Streptococcus pyogenes MGAS10750 4067287 YP_603374.1 CDS yaaA NC_008024.1 1846420 1847151 D hypothetical protein 1846420..1847151 Streptococcus pyogenes MGAS10750 4067288 YP_603375.1 CDS nrdG NC_008024.1 1847325 1847942 R Anaerobic ribonucleoside-triphosphate reductase activating protein complement(1847325..1847942) Streptococcus pyogenes MGAS10750 4067289 YP_603376.1 CDS MGAS10750_Spy1882 NC_008024.1 1847954 1848448 R acetyltransferase complement(1847954..1848448) Streptococcus pyogenes MGAS10750 4067290 YP_603377.1 CDS MGAS10750_Spy1883 NC_008024.1 1848457 1849398 R NAD-dependent oxidoreductase complement(1848457..1849398) Streptococcus pyogenes MGAS10750 4067291 YP_603378.1 CDS MGAS10750_Spy1884 NC_008024.1 1849421 1849567 R hypothetical protein complement(1849421..1849567) Streptococcus pyogenes MGAS10750 4067292 YP_603379.1 CDS nrdD NC_008024.1 1849751 1851949 R Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase complement(1849751..1851949) Streptococcus pyogenes MGAS10750 4067293 YP_603380.1 CDS MGAS10750_Spy1886 NC_008024.1 1852046 1853605 R hypothetical protein complement(1852046..1853605) Streptococcus pyogenes MGAS10750 4067294 YP_603381.1 CDS MGAS10750_Spy1887 NC_008024.1 1854019 1854324 R hypothetical protein complement(1854019..1854324) Streptococcus pyogenes MGAS10750 4067295 YP_603382.1 CDS MGAS10750_Spy1888 NC_008024.1 1854336 1854755 R similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein complement(1854336..1854755) Streptococcus pyogenes MGAS10750 4066614 YP_603383.1 CDS MGAS10750_Spy1889 NC_008024.1 1854752 1855021 R hypothetical protein complement(1854752..1855021) Streptococcus pyogenes MGAS10750 4066615 YP_603384.1 CDS spxA NC_008024.1 1855135 1855533 R the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; Spx family transcriptional regulator complement(1855135..1855533) Streptococcus pyogenes MGAS10750 4066616 YP_603385.1 CDS recA NC_008024.1 1855824 1856960 R catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A complement(1855824..1856960) Streptococcus pyogenes MGAS10750 4066617 YP_603386.1 CDS cinA NC_008024.1 1857049 1858320 R competence damage-inducible protein A complement(1857049..1858320) Streptococcus pyogenes MGAS10750 4066618 YP_603387.1 CDS tag NC_008024.1 1858379 1858960 R DNA-3-methyladenine glycosylase complement(1858379..1858960) Streptococcus pyogenes MGAS10750 4066619 YP_603388.1 CDS ruvA NC_008024.1 1858961 1859557 R plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA complement(1858961..1859557) Streptococcus pyogenes MGAS10750 4066620 YP_603389.1 CDS lmrP NC_008024.1 1859559 1860779 R multidrug resistance protein imrP complement(1859559..1860779) Streptococcus pyogenes MGAS10750 4066621 YP_603390.1 CDS mutL NC_008024.1 1860790 1862811 R This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein complement(1860790..1862811) Streptococcus pyogenes MGAS10750 4066622 YP_603391.1 CDS int3 NC_008024.1 1862867 1864030 R DNA integration/recombination/inversion protein complement(1862867..1864030) Streptococcus pyogenes MGAS10750 4066623 YP_603392.1 CDS MGAS10750_Spy1898 NC_008024.1 1864215 1864358 D hypothetical protein 1864215..1864358 Streptococcus pyogenes MGAS10750 4066624 YP_603393.1 CDS MGAS10750_Spy1899 NC_008024.1 1865256 1865903 R Cro/CI family transcriptional regulator complement(1865256..1865903) Streptococcus pyogenes MGAS10750 4066625 YP_603394.1 CDS MGAS10750_Spy1900 NC_008024.1 1866069 1866266 D Cro/CI family transcriptional regulator 1866069..1866266 Streptococcus pyogenes MGAS10750 4066626 YP_603395.1 CDS MGAS10750_Spy1901 NC_008024.1 1866256 1866894 D phage antirepressor protein 1866256..1866894 Streptococcus pyogenes MGAS10750 4066627 YP_603396.1 CDS MGAS10750_Spy1902 NC_008024.1 1866891 1867163 D Prophage antirepressor 1866891..1867163 Streptococcus pyogenes MGAS10750 4066628 YP_603397.1 CDS MGAS10750_Spy1903 NC_008024.1 1867419 1867751 D phage protein 1867419..1867751 Streptococcus pyogenes MGAS10750 4066629 YP_603398.1 CDS MGAS10750_Spy1904 NC_008024.1 1867748 1867969 D hypothetical protein 1867748..1867969 Streptococcus pyogenes MGAS10750 4066630 YP_603399.1 CDS MGAS10750_Spy1905 NC_008024.1 1867972 1868163 D phage protein 1867972..1868163 Streptococcus pyogenes MGAS10750 4066631 YP_603400.1 CDS MGAS10750_Spy1906 NC_008024.1 1868175 1868537 D phage protein 1868175..1868537 Streptococcus pyogenes MGAS10750 4066632 YP_603401.1 CDS MGAS10750_Spy1907 NC_008024.1 1868534 1868863 D phage protein 1868534..1868863 Streptococcus pyogenes MGAS10750 4066633 YP_603402.1 CDS MGAS10750_Spy1908 NC_008024.1 1868866 1869138 D phage protein 1868866..1869138 Streptococcus pyogenes MGAS10750 4068304 YP_603403.1 CDS MGAS10750_Spy1909 NC_008024.1 1869139 1869999 D phage protein 1869139..1869999 Streptococcus pyogenes MGAS10750 4068305 YP_603404.1 CDS MGAS10750_Spy1910 NC_008024.1 1870017 1871513 D DNA primase 1870017..1871513 Streptococcus pyogenes MGAS10750 4068306 YP_603405.1 CDS MGAS10750_Spy1911 NC_008024.1 1871805 1871963 D phage protein 1871805..1871963 Streptococcus pyogenes MGAS10750 4068307 YP_603406.1 CDS MGAS10750_Spy1912 NC_008024.1 1871969 1872142 D phage protein 1871969..1872142 Streptococcus pyogenes MGAS10750 4068308 YP_603407.1 CDS MGAS10750_Spy1913 NC_008024.1 1872144 1872410 D phage protein 1872144..1872410 Streptococcus pyogenes MGAS10750 4068309 YP_603408.1 CDS MGAS10750_Spy1914 NC_008024.1 1872417 1872575 D phage protein 1872417..1872575 Streptococcus pyogenes MGAS10750 4068310 YP_603409.1 CDS MGAS10750_Spy1915 NC_008024.1 1872676 1873278 D hypothetical protein 1872676..1873278 Streptococcus pyogenes MGAS10750 4068311 YP_603410.1 CDS MGAS10750_Spy1916 NC_008024.1 1873262 1873597 D hypothetical protein 1873262..1873597 Streptococcus pyogenes MGAS10750 4068312 YP_603411.1 CDS MGAS10750_Spy1917 NC_008024.1 1873732 1874139 D phage protein 1873732..1874139 Streptococcus pyogenes MGAS10750 4068313 YP_603412.1 CDS MGAS10750_Spy1918 NC_008024.1 1874212 1874658 D phage protein 1874212..1874658 Streptococcus pyogenes MGAS10750 4068314 YP_603413.1 CDS MGAS10750_Spy1919 NC_008024.1 1874733 1874933 D hypothetical protein 1874733..1874933 Streptococcus pyogenes MGAS10750 4068315 YP_603414.1 CDS MGAS10750_Spy1920 NC_008024.1 1875169 1875552 D phage encoded transcriptional regulator, ArpU family 1875169..1875552 Streptococcus pyogenes MGAS10750 4068316 YP_603415.1 CDS MGAS10750_Spy1921 NC_008024.1 1875717 1876370 D phage protein 1875717..1876370 Streptococcus pyogenes MGAS10750 4068317 YP_603416.1 CDS mutS NC_008024.1 1876766 1879321 R This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS complement(1876766..1879321) Streptococcus pyogenes MGAS10750 4068318 YP_603417.1 CDS MGAS10750_Spy1923 NC_008024.1 1879308 1879514 R hypothetical protein complement(1879308..1879514) Streptococcus pyogenes MGAS10750 4068319 YP_603418.1 CDS argR2 NC_008024.1 1879657 1880094 R arginine repressor, argR complement(1879657..1880094) Streptococcus pyogenes MGAS10750 4068320 YP_603419.1 CDS argS NC_008024.1 1880385 1882076 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1880385..1882076 Streptococcus pyogenes MGAS10750 4068321 YP_603420.1 CDS uviB NC_008024.1 1882146 1882472 D Bacteriocin uviB 1882146..1882472 Streptococcus pyogenes MGAS10750 4068322 YP_603421.1 CDS MGAS10750_Spy1927 NC_008024.1 1882499 1883371 R hypothetical protein complement(1882499..1883371) Streptococcus pyogenes MGAS10750 4066711 YP_603422.1 CDS MGAS10750_Spy1928 NC_008024.1 1883414 1884367 R hypothetical protein complement(1883414..1884367) Streptococcus pyogenes MGAS10750 4066712 YP_603423.1 CDS MGAS10750_Spy1929 NC_008024.1 1884312 1885253 R hypothetical protein complement(1884312..1885253) Streptococcus pyogenes MGAS10750 4066713 YP_603424.1 CDS aspS NC_008024.1 1885246 1887045 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(1885246..1887045) Streptococcus pyogenes MGAS10750 4066714 YP_603425.2 CDS hisS NC_008024.1 1887332 1888612 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(1887332..1888612) Streptococcus pyogenes MGAS10750 4066715 YP_603426.1 CDS rpmF NC_008024.1 1888832 1889014 D some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1888832..1889014 Streptococcus pyogenes MGAS10750 4066716 YP_603427.1 CDS rpmG NC_008024.1 1889030 1889179 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 1889030..1889179 Streptococcus pyogenes MGAS10750 4066717 YP_603428.1 CDS cadD NC_008024.1 1889461 1890087 D Cadmium resistance protein 1889461..1890087 Streptococcus pyogenes MGAS10750 4066718 YP_603429.1 CDS cadC NC_008024.1 1890069 1890437 D Cadmium efflux system accessory protein 1890069..1890437 Streptococcus pyogenes MGAS10750 4066719 YP_603430.1 CDS MGAS10750_Spy1936 NC_008024.1 1890631 1891404 D hypothetical protein 1890631..1891404 Streptococcus pyogenes MGAS10750 4066720 YP_603431.1 CDS MGAS10750_Spy1937 NC_008024.1 1891470 1892222 D FtsK/SpoIIIE family 1891470..1892222 Streptococcus pyogenes MGAS10750 4066721 YP_603432.1 CDS MGAS10750_Spy1938 NC_008024.1 1892219 1892821 D hypothetical protein 1892219..1892821 Streptococcus pyogenes MGAS10750 4066722 YP_603433.1 CDS MGAS10750_Spy1939 NC_008024.1 1893297 1893518 R transcriptional regulator complement(1893297..1893518) Streptococcus pyogenes MGAS10750 4066723 YP_603434.1 CDS MGAS10750_Spy1940 NC_008024.1 1893789 1893947 R hypothetical protein complement(1893789..1893947) Streptococcus pyogenes MGAS10750 4066724 YP_603435.1 CDS MGAS10750_Spy1941 NC_008024.1 1894032 1894874 D membrane protein 1894032..1894874 Streptococcus pyogenes MGAS10750 4066725 YP_603436.1 CDS MGAS10750_Spy1942 NC_008024.1 1894921 1895562 R MutT/nudix family protein; phosphohydrolase complement(1894921..1895562) Streptococcus pyogenes MGAS10750 4066726 YP_603437.1 CDS MGAS10750_Spy1943 NC_008024.1 1895474 1895629 R hypothetical protein complement(1895474..1895629) Streptococcus pyogenes MGAS10750 4066727 YP_603438.1 CDS MGAS10750_Spy1944 NC_008024.1 1895769 1896095 D PadR family transcriptional regulator 1895769..1896095 Streptococcus pyogenes MGAS10750 4066728 YP_603439.1 CDS MGAS10750_Spy1945 NC_008024.1 1896082 1896669 D hypothetical protein 1896082..1896669 Streptococcus pyogenes MGAS10750 4066729 YP_603440.1 CDS MGAS10750_Spy1946 NC_008024.1 1896666 1897745 D hypothetical protein 1896666..1897745 Streptococcus pyogenes MGAS10750 4066730 YP_603441.1 CDS MGAS10750_Spy1947 NC_008024.1 1897861 1900164 R phage infection protein complement(1897861..1900164) Streptococcus pyogenes MGAS10750 4066499 YP_603442.1 CDS MGAS10750_Spy1948 NC_008024.1 1900269 1900802 D TetR family transcriptional regulator 1900269..1900802 Streptococcus pyogenes MGAS10750 4066500 YP_603443.1 CDS rpsD NC_008024.1 1900957 1901568 R primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 complement(1900957..1901568) Streptococcus pyogenes MGAS10750 4066501 YP_603444.1 CDS MGAS10750_Spy1950 NC_008024.1 1902296 1902598 R hypothetical protein complement(1902296..1902598) Streptococcus pyogenes MGAS10750 4066502 YP_603445.1 CDS holB NC_008024.1 1902585 1903961 R unwinds double stranded DNA; replicative DNA helicase complement(1902585..1903961) Streptococcus pyogenes MGAS10750 4066503 YP_603446.1 CDS rplI NC_008024.1 1903982 1904434 R in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 complement(1903982..1904434) Streptococcus pyogenes MGAS10750 4066504 YP_603447.1 CDS MGAS10750_Spy1953 NC_008024.1 1904431 1906467 R phosphoesterase, DHH family protein complement(1904431..1906467) Streptococcus pyogenes MGAS10750 4066505 YP_603448.1 CDS gidA NC_008024.1 1906497 1908395 R GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA complement(1906497..1908395) Streptococcus pyogenes MGAS10750 4066506 YP_603449.1 CDS MGAS10750_Spy1955 NC_008024.1 1908519 1908836 R MutT/nudix family protein; phosphohydrolase complement(1908519..1908836) Streptococcus pyogenes MGAS10750 4066507 YP_603450.1 CDS mnmA NC_008024.1 1909609 1910748 R catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA complement(1909609..1910748) Streptococcus pyogenes MGAS10750 4066508 YP_603451.1 CDS sdhB NC_008024.1 1911022 1911699 D L-serinedehydratase beta subunit 1911022..1911699 Streptococcus pyogenes MGAS10750 4066509 YP_603452.1 CDS sdhA NC_008024.1 1911711 1912583 D L-serinedehydratase alpha subunit 1911711..1912583 Streptococcus pyogenes MGAS10750 4066510 YP_603453.1 CDS MGAS10750_Spy1959 NC_008024.1 1912997 1913611 R transglycosylase complement(1912997..1913611) Streptococcus pyogenes MGAS10750 4066511 YP_603454.1 CDS cbiQ NC_008024.1 1913982 1914782 R Hyaluronan ABC exporter permease complement(1913982..1914782) Streptococcus pyogenes MGAS10750 4066512 YP_603455.1 CDS cbiO NC_008024.1 1914775 1915617 R with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit complement(1914775..1915617) Streptococcus pyogenes MGAS10750 4066513 YP_603456.1 CDS cbiO NC_008024.1 1915593 1916483 R with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit complement(1915593..1916483) Streptococcus pyogenes MGAS10750 4066514 YP_603457.1 CDS MGAS10750_Spy1963 NC_008024.1 1916434 1916976 R CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase complement(1916434..1916976) Streptococcus pyogenes MGAS10750 4066515 YP_603458.1 CDS MGAS10750_Spy1964 NC_008024.1 1916990 1918015 R hypothetical protein complement(1916990..1918015) Streptococcus pyogenes MGAS10750 4066516 YP_603459.1 CDS MGAS10750_Spy1965 NC_008024.1 1918065 1919354 R Zinc protease complement(1918065..1919354) Streptococcus pyogenes MGAS10750 4066517 YP_603460.1 CDS MGAS10750_Spy1966 NC_008024.1 1919356 1920600 R Peptidase, M16 family complement(1919356..1920600) Streptococcus pyogenes MGAS10750 4066598 YP_603461.1 CDS MGAS10750_Spy1967 NC_008024.1 1920709 1921323 D hypothetical protein 1920709..1921323 Streptococcus pyogenes MGAS10750 4066599 YP_603462.1 CDS recF NC_008024.1 1921325 1922431 D Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 1921325..1922431 Streptococcus pyogenes MGAS10750 4066600 YP_603463.1 CDS MGAS10750_Spy1969 NC_008024.1 1922487 1923335 R glucose uptake family protein complement(1922487..1923335) Streptococcus pyogenes MGAS10750 4066601 YP_603464.1 CDS guaB NC_008024.1 1923554 1925035 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(1923554..1925035) Streptococcus pyogenes MGAS10750 4066602 YP_603465.2 CDS trsA NC_008024.1 1925343 1926365 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase II complement(1925343..1926365) Streptococcus pyogenes MGAS10750 4066603 YP_603466.1 CDS MGAS10750_Spy1972 NC_008024.1 1926457 1926582 R hypothetical protein complement(1926457..1926582) Streptococcus pyogenes MGAS10750 4066604 YP_603467.1 CDS MGAS10750_Spy1973 NC_008024.1 1926784 1927656 D hypothetical protein 1926784..1927656 Streptococcus pyogenes MGAS10750 4066605 YP_603468.1 CDS MGAS10750_Spy1974 NC_008024.1 1927736 1929355 D ABC transporter ATP-binding protein 1927736..1929355 Streptococcus pyogenes MGAS10750 4066606 YP_603469.1 CDS MGAS10750_Spy1975 NC_008024.1 1929438 1932014 D ABC transporter permease 1929438..1932014 Streptococcus pyogenes MGAS10750 4066607 YP_603470.1 CDS MGAS10750_Spy1976 NC_008024.1 1932885 1933871 R transposase complement(1932885..1933871) Streptococcus pyogenes MGAS10750 4066610 YP_603471.1 CDS MGAS10750_Spy1977 NC_008024.1 1934301 1934780 R SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase complement(1934301..1934780) Streptococcus pyogenes MGAS10750 4066612 YP_603472.1 CDS htrA NC_008024.1 1934992 1936215 D endopeptidase degP 1934992..1936215 Streptococcus pyogenes MGAS10750 4066613 YP_603473.1 CDS parB NC_008024.1 1936274 1937080 D chromosome partitioning protein parB 1936274..1937080 Streptococcus pyogenes MGAS10750 4066768 MGAS10750_SpyR02228 tRNA MGAS10750_SpyR02228 NC_008024.1 22128 22200 D tRNA-Val 22128..22200 Streptococcus pyogenes MGAS10750 4068352 MGAS10750_SpyR02229 tRNA MGAS10750_SpyR02229 NC_008024.1 22218 22290 D tRNA-Asp 22218..22290 Streptococcus pyogenes MGAS10750 4068353 MGAS10750_SpyR02230 tRNA MGAS10750_SpyR02230 NC_008024.1 22322 22394 D tRNA-Lys 22322..22394 Streptococcus pyogenes MGAS10750 4068354 MGAS10750_SpyR02231 tRNA MGAS10750_SpyR02231 NC_008024.1 22400 22481 D tRNA-Leu 22400..22481 Streptococcus pyogenes MGAS10750 4068355 MGAS10750_SpyR02232 tRNA MGAS10750_SpyR02232 NC_008024.1 22492 22564 D tRNA-Thr 22492..22564 Streptococcus pyogenes MGAS10750 4068356 MGAS10750_SpyR02233 tRNA MGAS10750_SpyR02233 NC_008024.1 22577 22648 D tRNA-Gly 22577..22648 Streptococcus pyogenes MGAS10750 4068357 MGAS10750_SpyR02234 tRNA MGAS10750_SpyR02234 NC_008024.1 22657 22741 D tRNA-Leu 22657..22741 Streptococcus pyogenes MGAS10750 4068358 MGAS10750_SpyR02235 tRNA MGAS10750_SpyR02235 NC_008024.1 22758 22834 D tRNA-Arg 22758..22834 Streptococcus pyogenes MGAS10750 4068359 MGAS10750_SpyR02236 tRNA MGAS10750_SpyR02236 NC_008024.1 22838 22911 D tRNA-Pro 22838..22911 Streptococcus pyogenes MGAS10750 4068360 MGAS10750_SpyR02240 tRNA MGAS10750_SpyR02240 NC_008024.1 28129 28201 D tRNA-Val 28129..28201 Streptococcus pyogenes MGAS10750 4068345 MGAS10750_SpyR02241 tRNA MGAS10750_SpyR02241 NC_008024.1 28219 28291 D tRNA-Asp 28219..28291 Streptococcus pyogenes MGAS10750 4068346 MGAS10750_SpyR02242 tRNA MGAS10750_SpyR02242 NC_008024.1 28323 28395 D tRNA-Lys 28323..28395 Streptococcus pyogenes MGAS10750 4068347 MGAS10750_SpyR02243 tRNA MGAS10750_SpyR02243 NC_008024.1 28401 28482 D tRNA-Leu 28401..28482 Streptococcus pyogenes MGAS10750 4068348 MGAS10750_SpyR02244 tRNA MGAS10750_SpyR02244 NC_008024.1 28493 28565 D tRNA-Thr 28493..28565 Streptococcus pyogenes MGAS10750 4068349 MGAS10750_SpyR02245 tRNA MGAS10750_SpyR02245 NC_008024.1 28578 28649 D tRNA-Gly 28578..28649 Streptococcus pyogenes MGAS10750 4068350 MGAS10750_SpyR02246 tRNA MGAS10750_SpyR02246 NC_008024.1 28658 28742 D tRNA-Leu 28658..28742 Streptococcus pyogenes MGAS10750 4067115 MGAS10750_SpyR02247 tRNA MGAS10750_SpyR02247 NC_008024.1 28759 28835 D tRNA-Arg 28759..28835 Streptococcus pyogenes MGAS10750 4067116 MGAS10750_SpyR02248 tRNA MGAS10750_SpyR02248 NC_008024.1 28839 28912 D tRNA-Pro 28839..28912 Streptococcus pyogenes MGAS10750 4067117 MGAS10750_SpyR02249 tRNA MGAS10750_SpyR02249 NC_008024.1 28918 28991 D tRNA-Met 28918..28991 Streptococcus pyogenes MGAS10750 4067118 MGAS10750_SpyR02250 tRNA MGAS10750_SpyR02250 NC_008024.1 29012 29085 D tRNA-Met 29012..29085 Streptococcus pyogenes MGAS10750 4067119 MGAS10750_SpyR02251 tRNA MGAS10750_SpyR02251 NC_008024.1 29111 29193 D tRNA-OTHER 29111..29193 Streptococcus pyogenes MGAS10750 4067120 MGAS10750_SpyR02252 tRNA MGAS10750_SpyR02252 NC_008024.1 29207 29280 D tRNA-Met 29207..29280 Streptococcus pyogenes MGAS10750 4067121 MGAS10750_SpyR02253 tRNA MGAS10750_SpyR02253 NC_008024.1 29301 29373 D tRNA-Phe 29301..29373 Streptococcus pyogenes MGAS10750 4067122 MGAS10750_SpyR02254 tRNA MGAS10750_SpyR02254 NC_008024.1 29386 29456 D tRNA-Gly 29386..29456 Streptococcus pyogenes MGAS10750 4067123 MGAS10750_SpyR02255 tRNA MGAS10750_SpyR02255 NC_008024.1 29491 29564 D tRNA-Ile 29491..29564 Streptococcus pyogenes MGAS10750 4067124 MGAS10750_SpyR02256 tRNA MGAS10750_SpyR02256 NC_008024.1 29574 29661 D tRNA-Ser 29574..29661 Streptococcus pyogenes MGAS10750 4067222 MGAS10750_SpyR02260 tRNA MGAS10750_SpyR02260 NC_008024.1 87305 87377 D tRNA-Val 87305..87377 Streptococcus pyogenes MGAS10750 4068458 MGAS10750_SpyR02261 tRNA MGAS10750_SpyR02261 NC_008024.1 87383 87453 D tRNA-Gly 87383..87453 Streptococcus pyogenes MGAS10750 4068459 MGAS10750_SpyR02262 tRNA MGAS10750_SpyR02262 NC_008024.1 87488 87561 D tRNA-Ile 87488..87561 Streptococcus pyogenes MGAS10750 4068460 MGAS10750_SpyR02263 tRNA MGAS10750_SpyR02263 NC_008024.1 87584 87655 D tRNA-Glu 87584..87655 Streptococcus pyogenes MGAS10750 4068461 MGAS10750_SpyR02264 tRNA MGAS10750_SpyR02264 NC_008024.1 87669 87751 D tRNA-OTHER 87669..87751 Streptococcus pyogenes MGAS10750 4068439 MGAS10750_SpyR02265 tRNA MGAS10750_SpyR02265 NC_008024.1 87765 87838 D tRNA-Met 87765..87838 Streptococcus pyogenes MGAS10750 4068440 MGAS10750_SpyR02266 tRNA MGAS10750_SpyR02266 NC_008024.1 87859 87931 D tRNA-Phe 87859..87931 Streptococcus pyogenes MGAS10750 4068441 MGAS10750_SpyR02267 tRNA MGAS10750_SpyR02267 NC_008024.1 87951 88031 D tRNA-Tyr 87951..88031 Streptococcus pyogenes MGAS10750 4068442 MGAS10750_SpyR02268 tRNA MGAS10750_SpyR02268 NC_008024.1 88038 88108 D tRNA-Trp 88038..88108 Streptococcus pyogenes MGAS10750 4068443 MGAS10750_SpyR02269 tRNA MGAS10750_SpyR02269 NC_008024.1 88120 88192 D tRNA-His 88120..88192 Streptococcus pyogenes MGAS10750 4068444 MGAS10750_SpyR02270 tRNA MGAS10750_SpyR02270 NC_008024.1 88201 88272 D tRNA-Gln 88201..88272 Streptococcus pyogenes MGAS10750 4068445 MGAS10750_SpyR02271 tRNA MGAS10750_SpyR02271 NC_008024.1 88292 88375 D tRNA-Leu 88292..88375 Streptococcus pyogenes MGAS10750 4068446 MGAS10750_SpyR02275 tRNA MGAS10750_SpyR02275 NC_008024.1 270376 270449 D tRNA-Asn 270376..270449 Streptococcus pyogenes MGAS10750 4068291 MGAS10750_SpyR02276 tRNA MGAS10750_SpyR02276 NC_008024.1 270529 270602 D tRNA-Arg 270529..270602 Streptococcus pyogenes MGAS10750 4068292 MGAS10750_SpyR02277 tRNA MGAS10750_SpyR02277 NC_008024.1 601256 601327 D tRNA-Arg 601256..601327 Streptococcus pyogenes MGAS10750 4067924 MGAS10750_SpyR02278 tRNA MGAS10750_SpyR02278 NC_008024.1 783875 783955 D tRNA-Tyr 783875..783955 Streptococcus pyogenes MGAS10750 4067753 MGAS10750_SpyR02279 tRNA MGAS10750_SpyR02279 NC_008024.1 784005 784079 D tRNA-Gln 784005..784079 Streptococcus pyogenes MGAS10750 4067754 MGAS10750_SpyR02280 tRNA MGAS10750_SpyR02280 NC_008024.1 785521 785592 D tRNA-Arg 785521..785592 Streptococcus pyogenes MGAS10750 4067756 MGAS10750_SpyR02281 tRNA MGAS10750_SpyR02281 NC_008024.1 1329987 1330057 D tRNA-Thr 1329987..1330057 Streptococcus pyogenes MGAS10750 4067558 MGAS10750_SpyR02282 tRNA MGAS10750_SpyR02282 NC_008024.1 1362492 1362563 R tRNA-Glu complement(1362492..1362563) Streptococcus pyogenes MGAS10750 4067553 MGAS10750_SpyR02283 tRNA MGAS10750_SpyR02283 NC_008024.1 1362586 1362659 R tRNA-Ile complement(1362586..1362659) Streptococcus pyogenes MGAS10750 4067554 MGAS10750_SpyR02284 tRNA MGAS10750_SpyR02284 NC_008024.1 1362695 1362767 R tRNA-Thr complement(1362695..1362767) Streptococcus pyogenes MGAS10750 4067555 MGAS10750_SpyR02285 tRNA MGAS10750_SpyR02285 NC_008024.1 1362778 1362859 R tRNA-Leu complement(1362778..1362859) Streptococcus pyogenes MGAS10750 4067556 MGAS10750_SpyR02286 tRNA MGAS10750_SpyR02286 NC_008024.1 1362865 1362937 R tRNA-Lys complement(1362865..1362937) Streptococcus pyogenes MGAS10750 4067557 MGAS10750_SpyR02287 tRNA MGAS10750_SpyR02287 NC_008024.1 1362969 1363041 R tRNA-Asp complement(1362969..1363041) Streptococcus pyogenes MGAS10750 4067531 MGAS10750_SpyR02288 tRNA MGAS10750_SpyR02288 NC_008024.1 1363059 1363131 R tRNA-Val complement(1363059..1363131) Streptococcus pyogenes MGAS10750 4067532 MGAS10750_SpyR02291 tRNA MGAS10750_SpyR02291 NC_008024.1 1366548 1366623 R tRNA-Ala complement(1366548..1366623) Streptococcus pyogenes MGAS10750 4067535 MGAS10750_SpyR02293 tRNA MGAS10750_SpyR02293 NC_008024.1 1462258 1462344 R tRNA-Ser complement(1462258..1462344) Streptococcus pyogenes MGAS10750 4067443 MGAS10750_SpyR02294 tRNA MGAS10750_SpyR02294 NC_008024.1 1599782 1599867 R tRNA-Leu complement(1599782..1599867) Streptococcus pyogenes MGAS10750 4066761 MGAS10750_SpyR02295 tRNA MGAS10750_SpyR02295 NC_008024.1 1609483 1609556 R tRNA-Arg complement(1609483..1609556) Streptococcus pyogenes MGAS10750 4066889 MGAS10750_SpyR02296 tRNA MGAS10750_SpyR02296 NC_008024.1 1609636 1609709 R tRNA-Asn complement(1609636..1609709) Streptococcus pyogenes MGAS10750 4066890 MGAS10750_SpyR02299 tRNA MGAS10750_SpyR02299 NC_008024.1 1613114 1613189 R tRNA-Ala complement(1613114..1613189) Streptococcus pyogenes MGAS10750 4066893 MGAS10750_SpyR02301 tRNA MGAS10750_SpyR02301 NC_008024.1 1748551 1748623 D tRNA-Lys 1748551..1748623 Streptococcus pyogenes MGAS10750 4068537 MGAS10750_SpyR02302 tRNA MGAS10750_SpyR02302 NC_008024.1 1818009 1818079 R tRNA-Cys complement(1818009..1818079) Streptococcus pyogenes MGAS10750 4067174 MGAS10750_SpyR02303 tRNA MGAS10750_SpyR02303 NC_008024.1 1932511 1932584 R tRNA-Asn complement(1932511..1932584) Streptococcus pyogenes MGAS10750 4066608 MGAS10750_SpyR02304 tRNA MGAS10750_SpyR02304 NC_008024.1 1932618 1932689 R tRNA-Glu complement(1932618..1932689) Streptococcus pyogenes MGAS10750 4066609 MGAS10750_SpyR02305 tRNA MGAS10750_SpyR02305 NC_008024.1 1934071 1934144 D tRNA-Arg 1934071..1934144 Streptococcus pyogenes MGAS10750 4066611 MGAS10750_SpyR02225 rRNA MGAS10750_SpyR02225 NC_008024.1 17054 18882 D 16S small subunit ribosomal RNA 17054..18882 Streptococcus pyogenes MGAS10750 4068230 MGAS10750_SpyR02226 rRNA MGAS10750_SpyR02226 NC_008024.1 19007 21909 D 23S large subunit ribosomal RNA 19007..21909 Streptococcus pyogenes MGAS10750 4068231 MGAS10750_SpyR02227 rRNA MGAS10750_SpyR02227 NC_008024.1 21994 22110 D 5S RNA 21994..22110 Streptococcus pyogenes MGAS10750 4068351 MGAS10750_SpyR02237 rRNA MGAS10750_SpyR02237 NC_008024.1 23055 24883 D 16S small subunit ribosomal RNA 23055..24883 Streptococcus pyogenes MGAS10750 4068342 MGAS10750_SpyR02238 rRNA MGAS10750_SpyR02238 NC_008024.1 25008 27910 D 23S large subunit ribosomal RNA 25008..27910 Streptococcus pyogenes MGAS10750 4068343 MGAS10750_SpyR02239 rRNA MGAS10750_SpyR02239 NC_008024.1 27995 28111 D 5S RNA 27995..28111 Streptococcus pyogenes MGAS10750 4068344 MGAS10750_SpyR02257 rRNA MGAS10750_SpyR02257 NC_008024.1 82231 84059 D 16S small subunit ribosomal RNA 82231..84059 Streptococcus pyogenes MGAS10750 4068455 MGAS10750_SpyR02258 rRNA MGAS10750_SpyR02258 NC_008024.1 84184 87086 D 23S large subunit ribosomal RNA 84184..87086 Streptococcus pyogenes MGAS10750 4068456 MGAS10750_SpyR02259 rRNA MGAS10750_SpyR02259 NC_008024.1 87171 87287 D 5S RNA 87171..87287 Streptococcus pyogenes MGAS10750 4068457 MGAS10750_SpyR02272 rRNA MGAS10750_SpyR02272 NC_008024.1 265314 267142 D 16S small subunit ribosomal RNA 265314..267142 Streptococcus pyogenes MGAS10750 4068250 MGAS10750_SpyR02273 rRNA MGAS10750_SpyR02273 NC_008024.1 267267 270169 D 23S large subunit ribosomal RNA 267267..270169 Streptococcus pyogenes MGAS10750 4068289 MGAS10750_SpyR02274 rRNA MGAS10750_SpyR02274 NC_008024.1 270254 270370 D 5S RNA 270254..270370 Streptococcus pyogenes MGAS10750 4068290 MGAS10750_SpyR02289 rRNA MGAS10750_SpyR02289 NC_008024.1 1363154 1363260 R 5S RNA complement(1363154..1363260) Streptococcus pyogenes MGAS10750 4067533 MGAS10750_SpyR02290 rRNA MGAS10750_SpyR02290 NC_008024.1 1363352 1366250 R 23S large subunit ribosomal RNA complement(1363352..1366250) Streptococcus pyogenes MGAS10750 4067534 MGAS10750_SpyR02292 rRNA MGAS10750_SpyR02292 NC_008024.1 1366676 1367906 R 16S small subunit ribosomal RNA complement(1366676..1367906) Streptococcus pyogenes MGAS10750 4067536 MGAS10750_SpyR02297 rRNA MGAS10750_SpyR02297 NC_008024.1 1609720 1609826 R 5S RNA complement(1609720..1609826) Streptococcus pyogenes MGAS10750 4066891 MGAS10750_SpyR02298 rRNA MGAS10750_SpyR02298 NC_008024.1 1609918 1612816 R 23S large subunit ribosomal RNA complement(1609918..1612816) Streptococcus pyogenes MGAS10750 4066892 MGAS10750_SpyR02300 rRNA MGAS10750_SpyR02300 NC_008024.1 1613242 1614472 R 16S small subunit ribosomal RNA complement(1613242..1614472) Streptococcus pyogenes MGAS10750 4066894