-- dump date   	20120504_162857
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
370569000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
370569000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370569000003	Walker A motif; other site
370569000004	ATP binding site [chemical binding]; other site
370569000005	Walker B motif; other site
370569000006	arginine finger; other site
370569000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
370569000008	DnaA box-binding interface [nucleotide binding]; other site
370569000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
370569000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
370569000011	putative DNA binding surface [nucleotide binding]; other site
370569000012	dimer interface [polypeptide binding]; other site
370569000013	beta-clamp/clamp loader binding surface; other site
370569000014	beta-clamp/translesion DNA polymerase binding surface; other site
370569000015	Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864
370569000016	GTP-binding protein YchF; Reviewed; Region: PRK09601
370569000017	YchF GTPase; Region: YchF; cd01900
370569000018	G1 box; other site
370569000019	GTP/Mg2+ binding site [chemical binding]; other site
370569000020	Switch I region; other site
370569000021	G2 box; other site
370569000022	Switch II region; other site
370569000023	G3 box; other site
370569000024	G4 box; other site
370569000025	G5 box; other site
370569000026	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
370569000027	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
370569000028	putative active site [active]
370569000029	catalytic residue [active]
370569000030	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
370569000031	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
370569000032	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
370569000033	ATP binding site [chemical binding]; other site
370569000034	putative Mg++ binding site [ion binding]; other site
370569000035	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
370569000036	nucleotide binding region [chemical binding]; other site
370569000037	ATP-binding site [chemical binding]; other site
370569000038	TRCF domain; Region: TRCF; cl04088
370569000039	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
370569000040	Septum formation initiator; Region: DivIC; cl11433
370569000041	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
370569000042	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
370569000043	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
370569000044	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
370569000045	Ligand Binding Site [chemical binding]; other site
370569000046	B3/4 domain; Region: B3_4; cl11458
370569000047	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
370569000048	active site
370569000049	FtsH Extracellular; Region: FtsH_ext; pfam06480
370569000050	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
370569000051	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370569000052	Walker A motif; other site
370569000053	ATP binding site [chemical binding]; other site
370569000054	Walker B motif; other site
370569000055	arginine finger; other site
370569000056	Peptidase family M41; Region: Peptidase_M41; pfam01434
370569000057	amino acid transporter; Region: 2A0306; TIGR00909
370569000058	Spore germination protein; Region: Spore_permease; cl15802
370569000059	Spore germination protein; Region: Spore_permease; cl15802
370569000060	Transposase; Region: DDE_Tnp_ISL3; pfam01610
370569000061	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
370569000062	NlpC/P60 family; Region: NLPC_P60; cl11438
370569000063	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269
370569000064	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
370569000065	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
370569000066	active site
370569000067	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
370569000068	Recombination protein O N terminal; Region: RecO_N; cl15812
370569000069	Recombination protein O C terminal; Region: RecO_C; pfam02565
370569000070	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
370569000071	Phosphopantetheine attachment site; Region: PP-binding; cl09936
370569000072	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
370569000073	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
370569000074	ATP binding site [chemical binding]; other site
370569000075	active site
370569000076	substrate binding site [chemical binding]; other site
370569000077	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
370569000078	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
370569000079	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
370569000080	dimerization interface [polypeptide binding]; other site
370569000081	ATP binding site [chemical binding]; other site
370569000082	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
370569000083	dimerization interface [polypeptide binding]; other site
370569000084	ATP binding site [chemical binding]; other site
370569000085	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
370569000086	putative active site [active]
370569000087	catalytic triad [active]
370569000088	amidophosphoribosyltransferase; Provisional; Region: PRK07272
370569000089	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
370569000090	active site
370569000091	tetramer interface [polypeptide binding]; other site
370569000092	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
370569000093	active site
370569000094	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
370569000095	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
370569000096	dimerization interface [polypeptide binding]; other site
370569000097	putative ATP binding site [chemical binding]; other site
370569000098	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
370569000099	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
370569000100	active site
370569000101	substrate binding site [chemical binding]; other site
370569000102	cosubstrate binding site; other site
370569000103	catalytic site [active]
370569000104	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
370569000105	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
370569000106	purine monophosphate binding site [chemical binding]; other site
370569000107	dimer interface [polypeptide binding]; other site
370569000108	putative catalytic residues [active]
370569000109	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
370569000110	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
370569000111	Bacterial SH3 domain; Region: SH3_3; cl02551
370569000112	NlpC/P60 family; Region: NLPC_P60; cl11438
370569000113	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
370569000114	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
370569000115	ATP-grasp domain; Region: ATP-grasp_4; cl03087
370569000116	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
370569000117	AIR carboxylase; Region: AIRC; cl00310
370569000118	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
370569000119	ATP-grasp domain; Region: ATP-grasp_4; cl03087
370569000120	AAA domain; Region: AAA_21; pfam13304
370569000121	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
370569000122	adenylosuccinate lyase; Provisional; Region: PRK07492
370569000123	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
370569000124	tetramer interface [polypeptide binding]; other site
370569000125	active site
370569000126	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370569000127	non-specific DNA binding site [nucleotide binding]; other site
370569000128	salt bridge; other site
370569000129	sequence-specific DNA binding site [nucleotide binding]; other site
370569000130	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
370569000131	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370569000132	Walker A motif; other site
370569000133	ATP binding site [chemical binding]; other site
370569000134	Walker B motif; other site
370569000135	arginine finger; other site
370569000136	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
370569000137	Low molecular weight phosphatase family; Region: LMWPc; cd00115
370569000138	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
370569000139	active site
370569000140	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
370569000141	MORN repeat; Region: MORN; cl14787
370569000142	OpgC protein; Region: OpgC_C; cl00792
370569000143	Acyltransferase family; Region: Acyl_transf_3; pfam01757
370569000144	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
370569000145	catalytic triad [active]
370569000146	catalytic triad [active]
370569000147	oxyanion hole [active]
370569000148	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
370569000149	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
370569000150	putative catalytic cysteine [active]
370569000151	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
370569000152	putative active site [active]
370569000153	metal binding site [ion binding]; metal-binding site
370569000154	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
370569000155	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
370569000156	NAD binding site [chemical binding]; other site
370569000157	substrate binding site [chemical binding]; other site
370569000158	catalytic Zn binding site [ion binding]; other site
370569000159	tetramer interface [polypeptide binding]; other site
370569000160	structural Zn binding site [ion binding]; other site
370569000161	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
370569000162	MatE; Region: MatE; cl10513
370569000163	MatE; Region: MatE; cl10513
370569000164	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
370569000165	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
370569000166	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
370569000167	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
370569000168	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
370569000169	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
370569000170	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
370569000171	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
370569000172	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
370569000173	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
370569000174	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
370569000175	putative translocon binding site; other site
370569000176	protein-rRNA interface [nucleotide binding]; other site
370569000177	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
370569000178	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
370569000179	G-X-X-G motif; other site
370569000180	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
370569000181	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
370569000182	23S rRNA interface [nucleotide binding]; other site
370569000183	5S rRNA interface [nucleotide binding]; other site
370569000184	putative antibiotic binding site [chemical binding]; other site
370569000185	L25 interface [polypeptide binding]; other site
370569000186	L27 interface [polypeptide binding]; other site
370569000187	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
370569000188	23S rRNA interface [nucleotide binding]; other site
370569000189	putative translocon interaction site; other site
370569000190	signal recognition particle (SRP54) interaction site; other site
370569000191	L23 interface [polypeptide binding]; other site
370569000192	trigger factor interaction site; other site
370569000193	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
370569000194	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
370569000195	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
370569000196	KOW motif; Region: KOW; cl00354
370569000197	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
370569000198	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
370569000199	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
370569000200	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
370569000201	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
370569000202	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
370569000203	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
370569000204	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
370569000205	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
370569000206	5S rRNA interface [nucleotide binding]; other site
370569000207	L27 interface [polypeptide binding]; other site
370569000208	23S rRNA interface [nucleotide binding]; other site
370569000209	L5 interface [polypeptide binding]; other site
370569000210	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
370569000211	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
370569000212	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
370569000213	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
370569000214	23S rRNA binding site [nucleotide binding]; other site
370569000215	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
370569000216	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
370569000217	SecY translocase; Region: SecY; pfam00344
370569000218	adenylate kinase; Reviewed; Region: adk; PRK00279
370569000219	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
370569000220	AMP-binding site [chemical binding]; other site
370569000221	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
370569000222	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
370569000223	rRNA binding site [nucleotide binding]; other site
370569000224	predicted 30S ribosome binding site; other site
370569000225	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
370569000226	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
370569000227	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
370569000228	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
370569000229	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
370569000230	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
370569000231	alphaNTD homodimer interface [polypeptide binding]; other site
370569000232	alphaNTD - beta interaction site [polypeptide binding]; other site
370569000233	alphaNTD - beta' interaction site [polypeptide binding]; other site
370569000234	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
370569000235	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
370569000236	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
370569000237	Helix-turn-helix domains; Region: HTH; cl00088
370569000238	Integrase core domain; Region: rve; cl01316
370569000239	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
370569000240	Transposase [DNA replication, recombination, and repair]; Region: COG5433
370569000241	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
370569000242	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
370569000243	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
370569000244	Helix-turn-helix domains; Region: HTH; cl00088
370569000245	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
370569000246	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235
370569000247	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
370569000248	ABC-ATPase subunit  interface; other site
370569000249	dimer interface [polypeptide binding]; other site
370569000250	putative PBP binding regions; other site
370569000251	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
370569000252	nucleotide binding site/active site [active]
370569000253	HIT family signature motif; other site
370569000254	catalytic residue [active]
370569000255	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
370569000256	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
370569000257	active site
370569000258	HIGH motif; other site
370569000259	dimer interface [polypeptide binding]; other site
370569000260	KMSKS motif; other site
370569000261	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
370569000262	RNA binding surface [nucleotide binding]; other site
370569000263	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
370569000264	Transglycosylase; Region: Transgly; cl07896
370569000265	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
370569000266	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
370569000267	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
370569000268	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
370569000269	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
370569000270	RPB1 interaction site [polypeptide binding]; other site
370569000271	RPB10 interaction site [polypeptide binding]; other site
370569000272	RPB11 interaction site [polypeptide binding]; other site
370569000273	RPB3 interaction site [polypeptide binding]; other site
370569000274	RPB12 interaction site [polypeptide binding]; other site
370569000275	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
370569000276	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
370569000277	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
370569000278	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
370569000279	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
370569000280	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
370569000281	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
370569000282	G-loop; other site
370569000283	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
370569000284	DNA binding site [nucleotide binding]
370569000285	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
370569000286	Protein of unknown function (DUF1033); Region: DUF1033; cl11549
370569000287	Type II/IV secretion system protein; Region: T2SE; pfam00437
370569000288	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569000289	Walker A motif; other site
370569000290	ATP binding site [chemical binding]; other site
370569000291	Walker B motif; other site
370569000292	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
370569000293	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
370569000294	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
370569000295	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
370569000296	Type II secretory pathway pseudopilin; Region: PulG; pfam11773
370569000297	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
370569000298	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
370569000299	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569000300	Acetokinase family; Region: Acetate_kinase; cl01029
370569000301	propionate/acetate kinase; Provisional; Region: PRK12379
370569000302	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
370569000303	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569000304	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
370569000305	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
370569000306	metal binding site [ion binding]; metal-binding site
370569000307	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
370569000308	catalytic residues [active]
370569000309	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
370569000310	putative tRNA-binding site [nucleotide binding]; other site
370569000311	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
370569000312	dimer interface [polypeptide binding]; other site
370569000313	ssDNA binding site [nucleotide binding]; other site
370569000314	tetramer (dimer of dimers) interface [polypeptide binding]; other site
370569000315	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
370569000316	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
370569000317	Substrate-binding site [chemical binding]; other site
370569000318	Substrate specificity [chemical binding]; other site
370569000319	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
370569000320	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
370569000321	FMN binding site [chemical binding]; other site
370569000322	active site
370569000323	catalytic residues [active]
370569000324	substrate binding site [chemical binding]; other site
370569000325	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
370569000326	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
370569000327	dimerization interface [polypeptide binding]; other site
370569000328	domain crossover interface; other site
370569000329	redox-dependent activation switch; other site
370569000330	Helix-turn-helix domains; Region: HTH; cl00088
370569000331	Helix-turn-helix domains; Region: HTH; cl00088
370569000332	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
370569000333	Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341
370569000334	TQXA domain; Region: TQXA_dom; TIGR03934
370569000335	Fibronectin binding repeat; Region: Fn_bind; pfam02986
370569000336	Fibronectin binding repeat; Region: Fn_bind; pfam02986
370569000337	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
370569000338	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
370569000339	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
370569000340	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
370569000341	C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425
370569000342	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
370569000343	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
370569000344	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
370569000345	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
370569000346	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
370569000347	active site
370569000348	catalytic site [active]
370569000349	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
370569000350	active site
370569000351	catalytic site [active]
370569000352	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
370569000353	active site
370569000354	catalytic site [active]
370569000355	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
370569000356	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
370569000357	Helix-turn-helix domains; Region: HTH; cl00088
370569000358	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
370569000359	dimerization interface [polypeptide binding]; other site
370569000360	putative acyltransferase; Provisional; Region: PRK05790
370569000361	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
370569000362	dimer interface [polypeptide binding]; other site
370569000363	active site
370569000364	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
370569000365	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
370569000366	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
370569000367	YheO-like PAS domain; Region: PAS_6; pfam08348
370569000368	Helix-turn-helix domains; Region: HTH; cl00088
370569000369	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
370569000370	homotrimer interaction site [polypeptide binding]; other site
370569000371	putative active site [active]
370569000372	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
370569000373	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
370569000374	V-type ATP synthase subunit I; Validated; Region: PRK05771
370569000375	V-type ATP synthase subunit K; Validated; Region: PRK06558
370569000376	ATP synthase subunit C; Region: ATP-synt_C; cl00466
370569000377	ATP synthase subunit C; Region: ATP-synt_C; cl00466
370569000378	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
370569000379	V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660
370569000380	ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632
370569000381	V-type ATP synthase subunit A; Provisional; Region: PRK04192
370569000382	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
370569000383	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
370569000384	Walker A motif/ATP binding site; other site
370569000385	Walker B motif; other site
370569000386	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
370569000387	V-type ATP synthase subunit B; Provisional; Region: PRK04196
370569000388	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
370569000389	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
370569000390	Walker A motif homologous position; other site
370569000391	Walker B motif; other site
370569000392	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
370569000393	ATP synthase subunit D; Region: ATP-synt_D; cl00613
370569000394	Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853
370569000395	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
370569000396	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
370569000397	GDP-binding site [chemical binding]; other site
370569000398	ACT binding site; other site
370569000399	IMP binding site; other site
370569000400	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
370569000401	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
370569000402	ligand binding site [chemical binding]; other site
370569000403	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
370569000404	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
370569000405	putative homodimer interface [polypeptide binding]; other site
370569000406	KOW motif; Region: KOW; cl00354
370569000407	Nicotine adenine dinucleotide glycohydrolase (NADase); Region: NADase_NGA; pfam07461
370569000408	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
370569000409	flagellar assembly protein H; Validated; Region: fliH; PRK06669
370569000410	cystathionine beta-lyase; Provisional; Region: PRK08064
370569000411	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
370569000412	homodimer interface [polypeptide binding]; other site
370569000413	substrate-cofactor binding pocket; other site
370569000414	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370569000415	catalytic residue [active]
370569000416	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
370569000417	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
370569000418	HIGH motif; other site
370569000419	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
370569000420	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
370569000421	active site
370569000422	KMSKS motif; other site
370569000423	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
370569000424	tRNA binding surface [nucleotide binding]; other site
370569000425	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
370569000426	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
370569000427	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
370569000428	active site
370569000429	P-loop; other site
370569000430	phosphorylation site [posttranslational modification]
370569000431	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
370569000432	active site
370569000433	phosphorylation site [posttranslational modification]
370569000434	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
370569000435	active site
370569000436	dimer interface [polypeptide binding]; other site
370569000437	magnesium binding site [ion binding]; other site
370569000438	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
370569000439	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
370569000440	AP (apurinic/apyrimidinic) site pocket; other site
370569000441	DNA interaction; other site
370569000442	Metal-binding active site; metal-binding site
370569000443	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
370569000444	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
370569000445	intersubunit interface [polypeptide binding]; other site
370569000446	active site
370569000447	Zn2+ binding site [ion binding]; other site
370569000448	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
370569000449	Helix-turn-helix domains; Region: HTH; cl00088
370569000450	PRD domain; Region: PRD; cl15445
370569000451	PRD domain; Region: PRD; cl15445
370569000452	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
370569000453	active site
370569000454	P-loop; other site
370569000455	phosphorylation site [posttranslational modification]
370569000456	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
370569000457	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
370569000458	This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea.  This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily.  The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294
370569000459	Walker A/P-loop; other site
370569000460	ATP binding site [chemical binding]; other site
370569000461	Q-loop/lid; other site
370569000462	ABC transporter signature motif; other site
370569000463	Walker B; other site
370569000464	D-loop; other site
370569000465	H-loop/switch region; other site
370569000466	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
370569000467	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
370569000468	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569000469	dimer interface [polypeptide binding]; other site
370569000470	conserved gate region; other site
370569000471	putative PBP binding loops; other site
370569000472	ABC-ATPase subunit interface; other site
370569000473	NMT1-like family; Region: NMT1_2; cl15260
370569000474	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
370569000475	DNA polymerase I; Provisional; Region: PRK05755
370569000476	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
370569000477	active site
370569000478	metal binding site 1 [ion binding]; metal-binding site
370569000479	putative 5' ssDNA interaction site; other site
370569000480	metal binding site 3; metal-binding site
370569000481	metal binding site 2 [ion binding]; metal-binding site
370569000482	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
370569000483	putative DNA binding site [nucleotide binding]; other site
370569000484	putative metal binding site [ion binding]; other site
370569000485	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
370569000486	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
370569000487	active site
370569000488	DNA binding site [nucleotide binding]
370569000489	catalytic site [active]
370569000490	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569000491	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
370569000492	metal binding site 2 [ion binding]; metal-binding site
370569000493	putative DNA binding helix; other site
370569000494	metal binding site 1 [ion binding]; metal-binding site
370569000495	dimer interface [polypeptide binding]; other site
370569000496	structural Zn2+ binding site [ion binding]; other site
370569000497	Protein of unknown function (DUF975); Region: DUF975; cl10504
370569000498	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
370569000499	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
370569000500	Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357
370569000501	CHY zinc finger; Region: zf-CHY; pfam05495
370569000502	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
370569000503	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
370569000504	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
370569000505	nucleoside/Zn binding site; other site
370569000506	dimer interface [polypeptide binding]; other site
370569000507	catalytic motif [active]
370569000508	Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279
370569000509	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
370569000510	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
370569000511	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
370569000512	active site
370569000513	dimer interface [polypeptide binding]; other site
370569000514	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
370569000515	dimer interface [polypeptide binding]; other site
370569000516	active site
370569000517	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
370569000518	Helix-turn-helix domains; Region: HTH; cl00088
370569000519	Helix-turn-helix domains; Region: HTH; cl00088
370569000520	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
370569000521	Transposase [DNA replication, recombination, and repair]; Region: COG5433
370569000522	Rhomboid family; Region: Rhomboid; cl11446
370569000523	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
370569000524	active site
370569000525	tetramer interface; other site
370569000526	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
370569000527	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569000528	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
370569000529	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
370569000530	Helix-turn-helix domains; Region: HTH; cl00088
370569000531	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
370569000532	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
370569000533	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569000534	Walker A/P-loop; other site
370569000535	ATP binding site [chemical binding]; other site
370569000536	Q-loop/lid; other site
370569000537	ABC transporter signature motif; other site
370569000538	Walker B; other site
370569000539	D-loop; other site
370569000540	H-loop/switch region; other site
370569000541	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
370569000542	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
370569000543	Glucan exporter ATP-binding protein.  In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor.  This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254
370569000544	Walker A/P-loop; other site
370569000545	ATP binding site [chemical binding]; other site
370569000546	Q-loop/lid; other site
370569000547	ABC transporter signature motif; other site
370569000548	Walker B; other site
370569000549	D-loop; other site
370569000550	H-loop/switch region; other site
370569000551	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
370569000552	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
370569000553	trimer interface [polypeptide binding]; other site
370569000554	active site
370569000555	DNA repair protein RadA; Provisional; Region: PRK11823
370569000556	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
370569000557	Walker A motif/ATP binding site; other site
370569000558	ATP binding site [chemical binding]; other site
370569000559	Walker B motif; other site
370569000560	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
370569000561	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
370569000562	active site clefts [active]
370569000563	zinc binding site [ion binding]; other site
370569000564	dimer interface [polypeptide binding]; other site
370569000565	Mitochondrial biogenesis AIM24; Region: AIM24; cl00884
370569000566	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
370569000567	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
370569000568	active site
370569000569	HIGH motif; other site
370569000570	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
370569000571	active site
370569000572	KMSKS motif; other site
370569000573	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
370569000574	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
370569000575	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
370569000576	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370569000577	active site
370569000578	phosphorylation site [posttranslational modification]
370569000579	intermolecular recognition site; other site
370569000580	dimerization interface [polypeptide binding]; other site
370569000581	LytTr DNA-binding domain; Region: LytTR; cl04498
370569000582	Ribonuclease P; Region: Ribonuclease_P; cl00457
370569000583	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
370569000584	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
370569000585	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
370569000586	G-X-X-G motif; other site
370569000587	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
370569000588	RxxxH motif; other site
370569000589	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
370569000590	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
370569000591	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
370569000592	putative active site cavity [active]
370569000593	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
370569000594	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
370569000595	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
370569000596	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569000597	dimer interface [polypeptide binding]; other site
370569000598	ABC-ATPase subunit interface; other site
370569000599	putative PBP binding loops; other site
370569000600	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
370569000601	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569000602	dimer interface [polypeptide binding]; other site
370569000603	conserved gate region; other site
370569000604	putative PBP binding loops; other site
370569000605	ABC-ATPase subunit interface; other site
370569000606	Domain of unknown function (DUF386); Region: DUF386; cl01047
370569000607	Protein of unknown function, DUF624; Region: DUF624; cl02369
370569000608	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
370569000609	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
370569000610	catalytic residue [active]
370569000611	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
370569000612	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
370569000613	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
370569000614	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
370569000615	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
370569000616	putative active site [active]
370569000617	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
370569000618	active site
370569000619	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
370569000620	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
370569000621	putative active site [active]
370569000622	putative metal binding site [ion binding]; other site
370569000623	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
370569000624	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569000625	GTPase RsgA; Reviewed; Region: PRK00098
370569000626	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
370569000627	RNA binding site [nucleotide binding]; other site
370569000628	homodimer interface [polypeptide binding]; other site
370569000629	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
370569000630	GTPase/Zn-binding domain interface [polypeptide binding]; other site
370569000631	GTP/Mg2+ binding site [chemical binding]; other site
370569000632	G4 box; other site
370569000633	G1 box; other site
370569000634	Switch I region; other site
370569000635	G2 box; other site
370569000636	G3 box; other site
370569000637	Switch II region; other site
370569000638	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
370569000639	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
370569000640	substrate binding site [chemical binding]; other site
370569000641	hexamer interface [polypeptide binding]; other site
370569000642	metal binding site [ion binding]; metal-binding site
370569000643	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
370569000644	Thiamine pyrophosphokinase; Region: TPK; cd07995
370569000645	active site
370569000646	dimerization interface [polypeptide binding]; other site
370569000647	thiamine binding site [chemical binding]; other site
370569000648	RmuC family; Region: RmuC; pfam02646
370569000649	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
370569000650	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492
370569000651	generic binding surface II; other site
370569000652	generic binding surface I; other site
370569000653	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
370569000654	pur operon repressor; Provisional; Region: PRK09213
370569000655	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
370569000656	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
370569000657	active site
370569000658	Septation ring formation regulator, EzrA; Region: EzrA; pfam06160
370569000659	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
370569000660	S17 interaction site [polypeptide binding]; other site
370569000661	S8 interaction site; other site
370569000662	16S rRNA interaction site [nucleotide binding]; other site
370569000663	streptomycin interaction site [chemical binding]; other site
370569000664	23S rRNA interaction site [nucleotide binding]; other site
370569000665	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
370569000666	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
370569000667	elongation factor G; Reviewed; Region: PRK00007
370569000668	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
370569000669	G1 box; other site
370569000670	putative GEF interaction site [polypeptide binding]; other site
370569000671	GTP/Mg2+ binding site [chemical binding]; other site
370569000672	Switch I region; other site
370569000673	G2 box; other site
370569000674	G3 box; other site
370569000675	Switch II region; other site
370569000676	G4 box; other site
370569000677	G5 box; other site
370569000678	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
370569000679	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
370569000680	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
370569000681	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569000682	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
370569000683	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
370569000684	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
370569000685	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569000686	Walker A/P-loop; other site
370569000687	ATP binding site [chemical binding]; other site
370569000688	Q-loop/lid; other site
370569000689	ABC transporter signature motif; other site
370569000690	Walker B; other site
370569000691	D-loop; other site
370569000692	H-loop/switch region; other site
370569000693	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
370569000694	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
370569000695	substrate binding pocket [chemical binding]; other site
370569000696	membrane-bound complex binding site; other site
370569000697	hinge residues; other site
370569000698	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
370569000699	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569000700	dimer interface [polypeptide binding]; other site
370569000701	conserved gate region; other site
370569000702	putative PBP binding loops; other site
370569000703	ABC-ATPase subunit interface; other site
370569000704	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
370569000705	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
370569000706	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
370569000707	Bacitracin resistance protein BacA; Region: BacA; cl00858
370569000708	Negative regulator of genetic competence (MecA); Region: MecA; cl02022
370569000709	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
370569000710	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
370569000711	Mg++ binding site [ion binding]; other site
370569000712	putative catalytic motif [active]
370569000713	substrate binding site [chemical binding]; other site
370569000714	FeS assembly ATPase SufC; Region: sufC; TIGR01978
370569000715	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
370569000716	Walker A/P-loop; other site
370569000717	ATP binding site [chemical binding]; other site
370569000718	Q-loop/lid; other site
370569000719	ABC transporter signature motif; other site
370569000720	Walker B; other site
370569000721	D-loop; other site
370569000722	H-loop/switch region; other site
370569000723	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
370569000724	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
370569000725	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
370569000726	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
370569000727	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
370569000728	catalytic residue [active]
370569000729	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
370569000730	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
370569000731	trimerization site [polypeptide binding]; other site
370569000732	active site
370569000733	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
370569000734	FeS assembly protein SufB; Region: sufB; TIGR01980
370569000735	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
370569000736	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
370569000737	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
370569000738	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
370569000739	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
370569000740	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
370569000741	peptide binding site [polypeptide binding]; other site
370569000742	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
370569000743	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569000744	dimer interface [polypeptide binding]; other site
370569000745	conserved gate region; other site
370569000746	putative PBP binding loops; other site
370569000747	ABC-ATPase subunit interface; other site
370569000748	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
370569000749	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
370569000750	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569000751	dimer interface [polypeptide binding]; other site
370569000752	conserved gate region; other site
370569000753	putative PBP binding loops; other site
370569000754	ABC-ATPase subunit interface; other site
370569000755	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
370569000756	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
370569000757	Walker A/P-loop; other site
370569000758	ATP binding site [chemical binding]; other site
370569000759	Q-loop/lid; other site
370569000760	ABC transporter signature motif; other site
370569000761	Walker B; other site
370569000762	D-loop; other site
370569000763	H-loop/switch region; other site
370569000764	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
370569000765	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
370569000766	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
370569000767	Walker A/P-loop; other site
370569000768	ATP binding site [chemical binding]; other site
370569000769	Q-loop/lid; other site
370569000770	ABC transporter signature motif; other site
370569000771	Walker B; other site
370569000772	D-loop; other site
370569000773	H-loop/switch region; other site
370569000774	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
370569000775	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
370569000776	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
370569000777	active site
370569000778	motif I; other site
370569000779	motif II; other site
370569000780	GTPase YqeH; Provisional; Region: PRK13796
370569000781	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
370569000782	GTP/Mg2+ binding site [chemical binding]; other site
370569000783	G4 box; other site
370569000784	G5 box; other site
370569000785	G1 box; other site
370569000786	Switch I region; other site
370569000787	G2 box; other site
370569000788	G3 box; other site
370569000789	Switch II region; other site
370569000790	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
370569000791	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
370569000792	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
370569000793	active site
370569000794	(T/H)XGH motif; other site
370569000795	Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713
370569000796	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
370569000797	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
370569000798	conserved cis-peptide bond; other site
370569000799	Oligomerisation domain; Region: Oligomerisation; cl00519
370569000800	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
370569000801	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370569000802	S-adenosylmethionine binding site [chemical binding]; other site
370569000803	hypothetical protein; Provisional; Region: PRK13670
370569000804	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
370569000805	Transcriptional regulator; Region: Transcrip_reg; cl00361
370569000806	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
370569000807	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
370569000808	substrate binding pocket [chemical binding]; other site
370569000809	membrane-bound complex binding site; other site
370569000810	hinge residues; other site
370569000811	NMT1-like family; Region: NMT1_2; cl15260
370569000812	MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport.  Other members of this system include the MetP permease and  the MetQ substrate binding protein.  ABC...; Region: ABC_MetN_methionine_transporter; cd03258
370569000813	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
370569000814	Walker A/P-loop; other site
370569000815	ATP binding site [chemical binding]; other site
370569000816	Q-loop/lid; other site
370569000817	ABC transporter signature motif; other site
370569000818	Walker B; other site
370569000819	D-loop; other site
370569000820	H-loop/switch region; other site
370569000821	NIL domain; Region: NIL; cl09633
370569000822	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
370569000823	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
370569000824	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
370569000825	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
370569000826	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569000827	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
370569000828	Cation transport protein; Region: TrkH; cl10514
370569000829	Methyltransferase domain; Region: Methyltransf_31; pfam13847
370569000830	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370569000831	S-adenosylmethionine binding site [chemical binding]; other site
370569000832	LemA family; Region: LemA; cl00742
370569000833	Peptidase family M48; Region: Peptidase_M48; cl12018
370569000834	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
370569000835	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
370569000836	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370569000837	active site
370569000838	phosphorylation site [posttranslational modification]
370569000839	intermolecular recognition site; other site
370569000840	dimerization interface [polypeptide binding]; other site
370569000841	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
370569000842	DNA binding site [nucleotide binding]
370569000843	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
370569000844	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
370569000845	dimerization interface [polypeptide binding]; other site
370569000846	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
370569000847	dimer interface [polypeptide binding]; other site
370569000848	phosphorylation site [posttranslational modification]
370569000849	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370569000850	ATP binding site [chemical binding]; other site
370569000851	Mg2+ binding site [ion binding]; other site
370569000852	G-X-G motif; other site
370569000853	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
370569000854	ATP cone domain; Region: ATP-cone; pfam03477
370569000855	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
370569000856	primosomal protein DnaI; Reviewed; Region: PRK08939
370569000857	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
370569000858	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370569000859	Walker A motif; other site
370569000860	ATP binding site [chemical binding]; other site
370569000861	Walker B motif; other site
370569000862	GTP-binding protein Der; Reviewed; Region: PRK00093
370569000863	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
370569000864	G1 box; other site
370569000865	GTP/Mg2+ binding site [chemical binding]; other site
370569000866	Switch I region; other site
370569000867	G2 box; other site
370569000868	Switch II region; other site
370569000869	G3 box; other site
370569000870	G4 box; other site
370569000871	G5 box; other site
370569000872	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
370569000873	G1 box; other site
370569000874	GTP/Mg2+ binding site [chemical binding]; other site
370569000875	Switch I region; other site
370569000876	G2 box; other site
370569000877	G3 box; other site
370569000878	Switch II region; other site
370569000879	G4 box; other site
370569000880	G5 box; other site
370569000881	SWIM zinc finger; Region: SWIM; cl15408
370569000882	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
370569000883	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
370569000884	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
370569000885	ATP binding site [chemical binding]; other site
370569000886	putative Mg++ binding site [ion binding]; other site
370569000887	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
370569000888	nucleotide binding region [chemical binding]; other site
370569000889	ATP-binding site [chemical binding]; other site
370569000890	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
370569000891	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
370569000892	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
370569000893	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
370569000894	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
370569000895	YceG-like family; Region: YceG; pfam02618
370569000896	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
370569000897	dimerization interface [polypeptide binding]; other site
370569000898	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
370569000899	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
370569000900	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
370569000901	OxaA-like protein precursor; Provisional; Region: PRK02463
370569000902	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
370569000903	Acylphosphatase; Region: Acylphosphatase; cl00551
370569000904	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
370569000905	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
370569000906	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
370569000907	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
370569000908	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
370569000909	Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536
370569000910	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
370569000911	putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491
370569000912	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
370569000913	active site
370569000914	dimerization interface [polypeptide binding]; other site
370569000915	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
370569000916	active site
370569000917	metal binding site [ion binding]; metal-binding site
370569000918	homotetramer interface [polypeptide binding]; other site
370569000919	FOG: CBS domain [General function prediction only]; Region: COG0517
370569000920	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
370569000921	site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436
370569000922	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
370569000923	DNA binding site [nucleotide binding]
370569000924	Int/Topo IB signature motif; other site
370569000925	active site
370569000926	catalytic residues [active]
370569000927	ScpA/B protein; Region: ScpA_ScpB; cl00598
370569000928	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
370569000929	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
370569000930	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
370569000931	RNA binding surface [nucleotide binding]; other site
370569000932	Pseudouridine synthases  are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870
370569000933	active site
370569000934	Haemolytic domain; Region: Haemolytic; cl00506
370569000935	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
370569000936	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
370569000937	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
370569000938	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
370569000939	active site
370569000940	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
370569000941	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569000942	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569000943	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
370569000944	Domain of unknown function DUF21; Region: DUF21; pfam01595
370569000945	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
370569000946	Transporter associated domain; Region: CorC_HlyC; cl08393
370569000947	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
370569000948	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370569000949	FeS/SAM binding site; other site
370569000950	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
370569000951	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
370569000952	DHHA2 domain; Region: DHHA2; pfam02833
370569000953	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
370569000954	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
370569000955	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
370569000956	ABC-ATPase subunit  interface; other site
370569000957	dimer interface [polypeptide binding]; other site
370569000958	putative PBP binding regions; other site
370569000959	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
370569000960	ABC-ATPase subunit  interface; other site
370569000961	dimer interface [polypeptide binding]; other site
370569000962	putative PBP binding regions; other site
370569000963	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
370569000964	Periplasmic binding protein FeuA.  These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138
370569000965	putative ligand binding residues [chemical binding]; other site
370569000966	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
370569000967	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
370569000968	Walker A/P-loop; other site
370569000969	ATP binding site [chemical binding]; other site
370569000970	Q-loop/lid; other site
370569000971	ABC transporter signature motif; other site
370569000972	Walker B; other site
370569000973	D-loop; other site
370569000974	H-loop/switch region; other site
370569000975	Transposase domain (DUF772); Region: DUF772; cl15789
370569000976	Transposase domain (DUF772); Region: DUF772; cl15789
370569000977	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
370569000978	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
370569000979	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
370569000980	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
370569000981	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
370569000982	MatE; Region: MatE; cl10513
370569000983	MviN-like protein; Region: MVIN; pfam03023
370569000984	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
370569000985	active site
370569000986	Clp protease; Region: CLP_protease; pfam00574
370569000987	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
370569000988	oligomer interface [polypeptide binding]; other site
370569000989	active site residues [active]
370569000990	Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453
370569000991	thymidylate kinase; Validated; Region: tmk; PRK00698
370569000992	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
370569000993	TMP-binding site; other site
370569000994	ATP-binding site [chemical binding]; other site
370569000995	DNA polymerase III subunit delta'; Validated; Region: PRK07276
370569000996	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569000997	PSP1 C-terminal conserved region; Region: PSP1; cl00770
370569000998	PSP1 C-terminal conserved region; Region: PSP1; cl00770
370569000999	TSC-22/dip/bun family; Region: TSC22; cl01853
370569001000	Predicted methyltransferases [General function prediction only]; Region: COG0313
370569001001	Predicted methyltransferases [General function prediction only]; Region: COG0313
370569001002	CutC family; Region: CutC; cl01218
370569001003	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
370569001004	ArsC family; Region: ArsC; pfam03960
370569001005	putative ArsC-like catalytic residues; other site
370569001006	putative TRX-like catalytic residues [active]
370569001007	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
370569001008	active site
370569001009	putative catalytic site [active]
370569001010	DNA binding site [nucleotide binding]
370569001011	putative phosphate binding site [ion binding]; other site
370569001012	metal binding site A [ion binding]; metal-binding site
370569001013	AP binding site [nucleotide binding]; other site
370569001014	metal binding site B [ion binding]; metal-binding site
370569001015	L-lactate oxidase; Region: L_lactate_ox; TIGR02708
370569001016	L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2.  This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737
370569001017	teramer interface [polypeptide binding]; other site
370569001018	active site
370569001019	FMN binding site [chemical binding]; other site
370569001020	catalytic residues [active]
370569001021	YSIRK type signal peptide; Region: YSIRK_signal; cl04650
370569001022	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
370569001023	putative active site [active]
370569001024	catalytic triad [active]
370569001025	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
370569001026	putative integrin binding motif; other site
370569001027	PA/protease domain interface [polypeptide binding]; other site
370569001028	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
370569001029	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
370569001030	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
370569001031	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
370569001032	Transposase [DNA replication, recombination, and repair]; Region: COG5433
370569001033	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
370569001034	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
370569001035	active site
370569001036	HIGH motif; other site
370569001037	KMSKS motif; other site
370569001038	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
370569001039	tRNA binding surface [nucleotide binding]; other site
370569001040	anticodon binding site; other site
370569001041	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
370569001042	dimer interface [polypeptide binding]; other site
370569001043	putative tRNA-binding site [nucleotide binding]; other site
370569001044	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
370569001045	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
370569001046	dimer interface [polypeptide binding]; other site
370569001047	putative radical transfer pathway; other site
370569001048	diiron center [ion binding]; other site
370569001049	tyrosyl radical; other site
370569001050	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
370569001051	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187
370569001052	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
370569001053	Class I ribonucleotide reductase; Region: RNR_I; cd01679
370569001054	active site
370569001055	dimer interface [polypeptide binding]; other site
370569001056	catalytic residues [active]
370569001057	effector binding site; other site
370569001058	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
370569001059	VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cd00233
370569001060	active site
370569001061	conformational flexibility of ligand binding pocket; other site
370569001062	ADP-ribosylating toxin turn-turn motif; other site
370569001063	Protein of unknown function (DUF3644); Region: DUF3644; pfam12358
370569001064	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
370569001065	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
370569001066	classical (c) SDRs; Region: SDR_c; cd05233
370569001067	NAD(P) binding site [chemical binding]; other site
370569001068	active site
370569001069	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
370569001070	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569001071	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
370569001072	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370569001073	putative substrate translocation pore; other site
370569001074	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
370569001075	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
370569001076	Substrate binding site; other site
370569001077	Mg++ binding site; other site
370569001078	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
370569001079	active site
370569001080	substrate binding site [chemical binding]; other site
370569001081	CoA binding site [chemical binding]; other site
370569001082	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
370569001083	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
370569001084	dimer interface [polypeptide binding]; other site
370569001085	ADP-ribose binding site [chemical binding]; other site
370569001086	active site
370569001087	nudix motif; other site
370569001088	metal binding site [ion binding]; metal-binding site
370569001089	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
370569001090	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
370569001091	Helix-turn-helix domains; Region: HTH; cl00088
370569001092	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
370569001093	FeoA domain; Region: FeoA; cl00838
370569001094	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
370569001095	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
370569001096	metal binding site [ion binding]; metal-binding site
370569001097	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
370569001098	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235
370569001099	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
370569001100	ABC-ATPase subunit  interface; other site
370569001101	dimer interface [polypeptide binding]; other site
370569001102	putative PBP binding regions; other site
370569001103	peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791
370569001104	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
370569001105	active site
370569001106	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569001107	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
370569001108	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
370569001109	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
370569001110	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
370569001111	23S rRNA interface [nucleotide binding]; other site
370569001112	L7/L12 interface [polypeptide binding]; other site
370569001113	putative thiostrepton binding site; other site
370569001114	L25 interface [polypeptide binding]; other site
370569001115	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
370569001116	mRNA/rRNA interface [nucleotide binding]; other site
370569001117	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
370569001118	putative nucleotide binding site [chemical binding]; other site
370569001119	uridine monophosphate binding site [chemical binding]; other site
370569001120	homohexameric interface [polypeptide binding]; other site
370569001121	ribosome recycling factor; Reviewed; Region: frr; PRK00083
370569001122	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
370569001123	hinge region; other site
370569001124	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
370569001125	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
370569001126	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
370569001127	Protein of unknown function (DUF1250); Region: DUF1250; cl11485
370569001128	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
370569001129	putative peptidoglycan binding site; other site
370569001130	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569001131	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
370569001132	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569001133	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
370569001134	putative uracil binding site [chemical binding]; other site
370569001135	putative active site [active]
370569001136	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
370569001137	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526
370569001138	GTPase Era; Reviewed; Region: era; PRK00089
370569001139	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
370569001140	G1 box; other site
370569001141	GTP/Mg2+ binding site [chemical binding]; other site
370569001142	Switch I region; other site
370569001143	G2 box; other site
370569001144	Switch II region; other site
370569001145	G3 box; other site
370569001146	G4 box; other site
370569001147	G5 box; other site
370569001148	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
370569001149	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677
370569001150	nudix motif; other site
370569001151	LytTr DNA-binding domain; Region: LytTR; cl04498
370569001152	The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export.  They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins.  The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228
370569001153	Walker A/P-loop; other site
370569001154	ATP binding site [chemical binding]; other site
370569001155	Q-loop/lid; other site
370569001156	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
370569001157	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296
370569001158	putative active site [active]
370569001159	Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439
370569001160	HTH-like domain; Region: HTH_21; pfam13276
370569001161	Integrase core domain; Region: rve; cl01316
370569001162	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
370569001163	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370569001164	active site
370569001165	phosphorylation site [posttranslational modification]
370569001166	intermolecular recognition site; other site
370569001167	dimerization interface [polypeptide binding]; other site
370569001168	LytTr DNA-binding domain; Region: LytTR; cl04498
370569001169	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
370569001170	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
370569001171	COMC family; Region: ComC; pfam03047
370569001172	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
370569001173	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
370569001174	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
370569001175	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39B; cd02418
370569001176	ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193
370569001177	putative active site [active]
370569001178	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
370569001179	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569001180	Walker A/P-loop; other site
370569001181	ATP binding site [chemical binding]; other site
370569001182	Q-loop/lid; other site
370569001183	ABC transporter signature motif; other site
370569001184	Walker B; other site
370569001185	D-loop; other site
370569001186	H-loop/switch region; other site
370569001187	Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439
370569001188	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370569001189	non-specific DNA binding site [nucleotide binding]; other site
370569001190	salt bridge; other site
370569001191	sequence-specific DNA binding site [nucleotide binding]; other site
370569001192	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
370569001193	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
370569001194	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
370569001195	DNA binding site [nucleotide binding]
370569001196	catalytic residue [active]
370569001197	H2TH interface [polypeptide binding]; other site
370569001198	putative catalytic residues [active]
370569001199	turnover-facilitating residue; other site
370569001200	intercalation triad [nucleotide binding]; other site
370569001201	8OG recognition residue [nucleotide binding]; other site
370569001202	putative reading head residues; other site
370569001203	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
370569001204	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
370569001205	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
370569001206	CoA-binding site [chemical binding]; other site
370569001207	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
370569001208	Domain of unknown function DUF87; Region: DUF87; pfam01935
370569001209	drug efflux system protein MdtG; Provisional; Region: PRK09874
370569001210	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370569001211	putative substrate translocation pore; other site
370569001212	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
370569001213	Preprotein translocase SecG subunit; Region: SecG; cl09123
370569001214	ribonuclease R; Region: RNase_R; TIGR02063
370569001215	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
370569001216	RNB domain; Region: RNB; pfam00773
370569001217	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471
370569001218	RNA binding site [nucleotide binding]; other site
370569001219	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
370569001220	SmpB-tmRNA interface; other site
370569001221	Glutamine cyclotransferase; Region: Glu_cyclase_2; pfam05096
370569001222	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
370569001223	putative substrate binding pocket [chemical binding]; other site
370569001224	AC domain interface; other site
370569001225	catalytic triad [active]
370569001226	AB domain interface; other site
370569001227	interchain disulfide; other site
370569001228	Protein of unknown function (DUF979); Region: DUF979; cl01572
370569001229	Protein of unknown function (DUF969); Region: DUF969; cl01573
370569001230	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
370569001231	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
370569001232	Ligand binding site; other site
370569001233	Putative Catalytic site; other site
370569001234	DXD motif; other site
370569001235	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
370569001236	dimer interface [polypeptide binding]; other site
370569001237	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
370569001238	active site
370569001239	metal binding site [ion binding]; metal-binding site
370569001240	glutathione binding site [chemical binding]; other site
370569001241	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
370569001242	dimer interface [polypeptide binding]; other site
370569001243	FMN binding site [chemical binding]; other site
370569001244	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
370569001245	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
370569001246	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
370569001247	active site
370569001248	catabolite control protein A; Region: ccpA; TIGR01481
370569001249	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
370569001250	DNA binding site [nucleotide binding]
370569001251	domain linker motif; other site
370569001252	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
370569001253	dimerization interface [polypeptide binding]; other site
370569001254	effector binding site; other site
370569001255	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
370569001256	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
370569001257	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
370569001258	putative ADP-binding pocket [chemical binding]; other site
370569001259	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
370569001260	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
370569001261	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
370569001262	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
370569001263	active site
370569001264	dimer interface [polypeptide binding]; other site
370569001265	motif 1; other site
370569001266	motif 2; other site
370569001267	motif 3; other site
370569001268	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
370569001269	anticodon binding site; other site
370569001270	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
370569001271	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569001272	Walker A/P-loop; other site
370569001273	ATP binding site [chemical binding]; other site
370569001274	Q-loop/lid; other site
370569001275	ABC transporter signature motif; other site
370569001276	Walker B; other site
370569001277	D-loop; other site
370569001278	H-loop/switch region; other site
370569001279	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
370569001280	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
370569001281	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
370569001282	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
370569001283	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
370569001284	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
370569001285	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
370569001286	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
370569001287	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
370569001288	DAK2 domain; Region: Dak2; cl03685
370569001289	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
370569001290	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
370569001291	amphipathic channel; other site
370569001292	Asn-Pro-Ala signature motifs; other site
370569001293	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
370569001294	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
370569001295	dimer interface [polypeptide binding]; other site
370569001296	active site
370569001297	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
370569001298	AMP-binding enzyme; Region: AMP-binding; cl15778
370569001299	peptide synthase; Validated; Region: PRK05691
370569001300	Protein of unknown function (DUF3114); Region: DUF3114; pfam11311
370569001301	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
370569001302	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370569001303	active site
370569001304	phosphorylation site [posttranslational modification]
370569001305	intermolecular recognition site; other site
370569001306	dimerization interface [polypeptide binding]; other site
370569001307	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
370569001308	DNA binding site [nucleotide binding]
370569001309	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
370569001310	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
370569001311	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
370569001312	dimer interface [polypeptide binding]; other site
370569001313	phosphorylation site [posttranslational modification]
370569001314	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370569001315	ATP binding site [chemical binding]; other site
370569001316	Mg2+ binding site [ion binding]; other site
370569001317	G-X-G motif; other site
370569001318	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
370569001319	ribonuclease III; Reviewed; Region: rnc; PRK00102
370569001320	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
370569001321	dimerization interface [polypeptide binding]; other site
370569001322	active site
370569001323	metal binding site [ion binding]; metal-binding site
370569001324	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
370569001325	dsRNA binding site [nucleotide binding]; other site
370569001326	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
370569001327	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
370569001328	Walker A/P-loop; other site
370569001329	ATP binding site [chemical binding]; other site
370569001330	Q-loop/lid; other site
370569001331	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
370569001332	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
370569001333	ABC transporter signature motif; other site
370569001334	Walker B; other site
370569001335	D-loop; other site
370569001336	H-loop/switch region; other site
370569001337	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370569001338	non-specific DNA binding site [nucleotide binding]; other site
370569001339	salt bridge; other site
370569001340	sequence-specific DNA binding site [nucleotide binding]; other site
370569001341	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
370569001342	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
370569001343	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
370569001344	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
370569001345	shikimate binding site; other site
370569001346	NAD(P) binding site [chemical binding]; other site
370569001347	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
370569001348	GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478
370569001349	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644
370569001350	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
370569001351	Archaeal S-adenosylmethionine synthetase [Amino acid transport and metabolism]; Region: MetK; COG1812
370569001352	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
370569001353	active site
370569001354	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
370569001355	active site
370569001356	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
370569001357	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569001358	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
370569001359	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569001360	Ferroportin1 (FPN1); Region: FPN1; pfam06963
370569001361	H+ Antiporter protein; Region: 2A0121; TIGR00900
370569001362	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
370569001363	RelB antitoxin; Region: RelB; cl01171
370569001364	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
370569001365	Phage-related protein [Function unknown]; Region: COG4695; cl01923
370569001366	Fic family protein [Function unknown]; Region: COG3177
370569001367	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
370569001368	active site
370569001369	dimer interface [polypeptide binding]; other site
370569001370	motif 2; other site
370569001371	motif 3; other site
370569001372	Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439
370569001373	ATP-grasp domain; Region: ATP-grasp_4; cl03087
370569001374	ATP-grasp domain; Region: ATP-grasp_4; cl03087
370569001375	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
370569001376	putative dimer interface [polypeptide binding]; other site
370569001377	catalytic triad [active]
370569001378	histidyl-tRNA synthetase; Region: hisS; TIGR00442
370569001379	Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124
370569001380	Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124
370569001381	Integrase core domain; Region: rve; cl01316
370569001382	Integrase core domain; Region: rve_3; cl15866
370569001383	Helix-turn-helix domains; Region: HTH; cl00088
370569001384	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
370569001385	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
370569001386	active site
370569001387	motif I; other site
370569001388	motif II; other site
370569001389	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
370569001390	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
370569001391	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
370569001392	active site
370569001393	motif I; other site
370569001394	motif II; other site
370569001395	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
370569001396	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
370569001397	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
370569001398	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
370569001399	P loop; other site
370569001400	GTP binding site [chemical binding]; other site
370569001401	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370569001402	Major Facilitator Superfamily; Region: MFS_1; pfam07690
370569001403	putative substrate translocation pore; other site
370569001404	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370569001405	transcriptional antiterminator BglG; Provisional; Region: PRK09772
370569001406	CAT RNA binding domain; Region: CAT_RBD; cl03904
370569001407	PRD domain; Region: PRD; cl15445
370569001408	PRD domain; Region: PRD; cl15445
370569001409	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
370569001410	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
370569001411	active site turn [active]
370569001412	phosphorylation site [posttranslational modification]
370569001413	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
370569001414	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
370569001415	HPr interaction site; other site
370569001416	glycerol kinase (GK) interaction site [polypeptide binding]; other site
370569001417	active site
370569001418	phosphorylation site [posttranslational modification]
370569001419	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
370569001420	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
370569001421	Predicted permeases [General function prediction only]; Region: COG0701
370569001422	Predicted permease; Region: DUF318; pfam03773
370569001423	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
370569001424	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
370569001425	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
370569001426	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
370569001427	RNA binding site [nucleotide binding]; other site
370569001428	hypothetical protein; Provisional; Region: PRK04351
370569001429	SprT homologues; Region: SprT; cl01182
370569001430	PspC domain; Region: PspC; cl00864
370569001431	HPr kinase/phosphorylase; Provisional; Region: PRK05428
370569001432	DRTGG domain; Region: DRTGG; cl12147
370569001433	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
370569001434	Hpr binding site; other site
370569001435	active site
370569001436	homohexamer subunit interaction site [polypeptide binding]; other site
370569001437	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
370569001438	Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972
370569001439	YtxH-like protein; Region: YtxH; cl02079
370569001440	Protein of unknown function (DUF3270); Region: DUF3270; pfam11674
370569001441	Peptidase family U32; Region: Peptidase_U32; cl03113
370569001442	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
370569001443	Peptidase family U32; Region: Peptidase_U32; cl03113
370569001444	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; cl01839
370569001445	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
370569001446	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
370569001447	dimer interface [polypeptide binding]; other site
370569001448	putative anticodon binding site; other site
370569001449	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
370569001450	motif 1; other site
370569001451	active site
370569001452	motif 2; other site
370569001453	motif 3; other site
370569001454	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
370569001455	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
370569001456	motif II; other site
370569001457	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
370569001458	catalytic core [active]
370569001459	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
370569001460	putative deacylase active site [active]
370569001461	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
370569001462	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
370569001463	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
370569001464	active site
370569001465	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
370569001466	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
370569001467	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
370569001468	catalytic residues [active]
370569001469	dimer interface [polypeptide binding]; other site
370569001470	oligoendopeptidase F; Region: pepF; TIGR00181
370569001471	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
370569001472	Zn binding site [ion binding]; other site
370569001473	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656
370569001474	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
370569001475	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
370569001476	elongation factor Tu; Reviewed; Region: PRK00049
370569001477	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
370569001478	G1 box; other site
370569001479	GEF interaction site [polypeptide binding]; other site
370569001480	GTP/Mg2+ binding site [chemical binding]; other site
370569001481	Switch I region; other site
370569001482	G2 box; other site
370569001483	G3 box; other site
370569001484	Switch II region; other site
370569001485	G4 box; other site
370569001486	G5 box; other site
370569001487	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
370569001488	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
370569001489	Antibiotic Binding Site [chemical binding]; other site
370569001490	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
370569001491	substrate binding site [chemical binding]; other site
370569001492	dimer interface [polypeptide binding]; other site
370569001493	catalytic triad [active]
370569001494	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
370569001495	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
370569001496	sugar phosphate phosphatase; Provisional; Region: PRK10513
370569001497	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
370569001498	motif II; other site
370569001499	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
370569001500	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
370569001501	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370569001502	Zn2+ binding site [ion binding]; other site
370569001503	Mg2+ binding site [ion binding]; other site
370569001504	Domain of unknown function (DUF1934); Region: DUF1934; cl01870
370569001505	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
370569001506	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
370569001507	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
370569001508	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
370569001509	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
370569001510	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
370569001511	Transcriptional regulators [Transcription]; Region: PurR; COG1609
370569001512	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
370569001513	DNA binding site [nucleotide binding]
370569001514	domain linker motif; other site
370569001515	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
370569001516	putative dimerization interface [polypeptide binding]; other site
370569001517	putative ligand binding site [chemical binding]; other site
370569001518	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
370569001519	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
370569001520	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
370569001521	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
370569001522	active site
370569001523	phosphorylation site [posttranslational modification]
370569001524	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
370569001525	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
370569001526	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
370569001527	NADP binding site [chemical binding]; other site
370569001528	homodimer interface [polypeptide binding]; other site
370569001529	active site
370569001530	hypothetical protein; Provisional; Region: PRK09273
370569001531	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
370569001532	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
370569001533	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
370569001534	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
370569001535	substrate binding site [chemical binding]; other site
370569001536	ATP binding site [chemical binding]; other site
370569001537	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
370569001538	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
370569001539	active site
370569001540	intersubunit interface [polypeptide binding]; other site
370569001541	catalytic residue [active]
370569001542	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
370569001543	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
370569001544	motif II; other site
370569001545	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
370569001546	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
370569001547	peptide chain release factor 2; Validated; Region: prfB; PRK00578
370569001548	RF-1 domain; Region: RF-1; cl02875
370569001549	RF-1 domain; Region: RF-1; cl02875
370569001550	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
370569001551	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569001552	Walker A/P-loop; other site
370569001553	ATP binding site [chemical binding]; other site
370569001554	Q-loop/lid; other site
370569001555	ABC transporter signature motif; other site
370569001556	Walker B; other site
370569001557	D-loop; other site
370569001558	H-loop/switch region; other site
370569001559	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
370569001560	FtsX-like permease family; Region: FtsX; cl15850
370569001561	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
370569001562	acetoin reductase; Validated; Region: PRK08643
370569001563	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
370569001564	NAD binding site [chemical binding]; other site
370569001565	homotetramer interface [polypeptide binding]; other site
370569001566	homodimer interface [polypeptide binding]; other site
370569001567	active site
370569001568	substrate binding site [chemical binding]; other site
370569001569	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246
370569001570	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
370569001571	active site
370569001572	catalytic site [active]
370569001573	substrate binding site [chemical binding]; other site
370569001574	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569001575	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569001576	aspartate aminotransferase; Provisional; Region: PRK05764
370569001577	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
370569001578	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370569001579	homodimer interface [polypeptide binding]; other site
370569001580	catalytic residue [active]
370569001581	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
370569001582	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
370569001583	putative dimer interface [polypeptide binding]; other site
370569001584	putative anticodon binding site; other site
370569001585	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
370569001586	homodimer interface [polypeptide binding]; other site
370569001587	motif 1; other site
370569001588	motif 2; other site
370569001589	active site
370569001590	motif 3; other site
370569001591	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
370569001592	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
370569001593	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
370569001594	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
370569001595	dimer interface [polypeptide binding]; other site
370569001596	phosphate binding site [ion binding]; other site
370569001597	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
370569001598	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
370569001599	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
370569001600	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
370569001601	catalytic residues [active]
370569001602	catalytic nucleophile [active]
370569001603	Presynaptic Site I dimer interface [polypeptide binding]; other site
370569001604	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
370569001605	Synaptic Flat tetramer interface [polypeptide binding]; other site
370569001606	Synaptic Site I dimer interface [polypeptide binding]; other site
370569001607	DNA binding site [nucleotide binding]
370569001608	Recombinase; Region: Recombinase; pfam07508
370569001609	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
370569001610	Short C-terminal domain; Region: SHOCT; cl01373
370569001611	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
370569001612	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370569001613	non-specific DNA binding site [nucleotide binding]; other site
370569001614	salt bridge; other site
370569001615	sequence-specific DNA binding site [nucleotide binding]; other site
370569001616	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
370569001617	Catalytic site [active]
370569001618	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
370569001619	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370569001620	non-specific DNA binding site [nucleotide binding]; other site
370569001621	salt bridge; other site
370569001622	sequence-specific DNA binding site [nucleotide binding]; other site
370569001623	phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618
370569001624	AAA domain; Region: AAA_24; pfam13479
370569001625	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569001626	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
370569001627	nucleotide binding region [chemical binding]; other site
370569001628	ATP-binding site [chemical binding]; other site
370569001629	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
370569001630	Protein of unknown function (DUF669); Region: DUF669; pfam05037
370569001631	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
370569001632	polymerase nucleotide-binding site; other site
370569001633	DNA-binding residues [nucleotide binding]; DNA binding site
370569001634	nucleotide binding site [chemical binding]; other site
370569001635	primase nucleotide-binding site [nucleotide binding]; other site
370569001636	Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362
370569001637	D5 N terminal like; Region: D5_N; cl07360
370569001638	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
370569001639	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
370569001640	Domain of Unknown Function (DUF1599); Region: DUF1599; pfam07659
370569001641	YopX protein; Region: YopX; cl09859
370569001642	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569001643	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569001644	Protein of unknown function (DUF1642); Region: DUF1642; pfam07852
370569001645	Protein of unknown function (DUF1492); Region: DUF1492; pfam07374
370569001646	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569001647	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
370569001648	YcfA-like protein; Region: YcfA; cl00752
370569001649	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
370569001650	Phage terminase, small subunit; Region: Terminase_4; cl01525
370569001651	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
370569001652	Phage Terminase; Region: Terminase_1; pfam03354
370569001653	Phage portal protein; Region: Phage_portal; pfam04860
370569001654	Phage-related protein [Function unknown]; Region: COG4695; cl01923
370569001655	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
370569001656	oligomer interface [polypeptide binding]; other site
370569001657	active site residues [active]
370569001658	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
370569001659	Phage capsid family; Region: Phage_capsid; pfam05065
370569001660	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
370569001661	oligomerization interface [polypeptide binding]; other site
370569001662	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
370569001663	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
370569001664	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
370569001665	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
370569001666	Phage-related protein [Function unknown]; Region: COG4722; cl15832
370569001667	Phage tail protein; Region: Sipho_tail; pfam05709
370569001668	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
370569001669	Hyaluronidase protein (HylP); Region: Hyaluronidase_1; pfam07212
370569001670	gp58-like protein; Region: Gp58; pfam07902
370569001671	Protein of unknown function (DUF1617); Region: DUF1617; pfam07761
370569001672	Bacteriophage holin; Region: Phage_holin_1; cl02344
370569001673	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
370569001674	NlpC/P60 family; Region: NLPC_P60; cl11438
370569001675	Bacterial SH3 domain; Region: SH3_3; cl02551
370569001676	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
370569001677	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
370569001678	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
370569001679	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
370569001680	Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690
370569001681	Peptidase family C69; Region: Peptidase_C69; pfam03577
370569001682	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
370569001683	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
370569001684	metal binding site [ion binding]; metal-binding site
370569001685	YodA lipocalin-like domain; Region: YodA; cl01365
370569001686	Transposase domain (DUF772); Region: DUF772; cl15789
370569001687	Transposase domain (DUF772); Region: DUF772; cl15789
370569001688	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
370569001689	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
370569001690	DNA-binding site [nucleotide binding]; DNA binding site
370569001691	UTRA domain; Region: UTRA; cl01230
370569001692	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
370569001693	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
370569001694	dimer interface [polypeptide binding]; other site
370569001695	active site
370569001696	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
370569001697	putative active site [active]
370569001698	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
370569001699	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
370569001700	DHH family; Region: DHH; pfam01368
370569001701	DHHA1 domain; Region: DHHA1; pfam02272
370569001702	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
370569001703	Chorismate mutase type II; Region: CM_2; cl00693
370569001704	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
370569001705	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
370569001706	Cl- selectivity filter; other site
370569001707	Cl- binding residues [ion binding]; other site
370569001708	pore gating glutamate residue; other site
370569001709	dimer interface [polypeptide binding]; other site
370569001710	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
370569001711	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
370569001712	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
370569001713	motif II; other site
370569001714	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
370569001715	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370569001716	Mg2+ binding site [ion binding]; other site
370569001717	G-X-G motif; other site
370569001718	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
370569001719	anchoring element; other site
370569001720	dimer interface [polypeptide binding]; other site
370569001721	ATP binding site [chemical binding]; other site
370569001722	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
370569001723	active site
370569001724	putative metal-binding site [ion binding]; other site
370569001725	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
370569001726	septation ring formation regulator EzrA; Provisional; Region: PRK04778
370569001727	Protein of unknown function (DUF1694); Region: DUF1694; cl02318
370569001728	enolase; Provisional; Region: eno; PRK00077
370569001729	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
370569001730	dimer interface [polypeptide binding]; other site
370569001731	metal binding site [ion binding]; metal-binding site
370569001732	substrate binding pocket [chemical binding]; other site
370569001733	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
370569001734	Transposase; Region: DEDD_Tnp_IS110; pfam01548
370569001735	Helix-turn-helix domains; Region: HTH; cl00088
370569001736	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
370569001737	MAEBL; Provisional; Region: PTZ00121
370569001738	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
370569001739	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
370569001740	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
370569001741	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
370569001742	bacteriocin protoxin, streptolysin S family; Region: streptolysinS; TIGR03602
370569001743	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
370569001744	putative FMN binding site [chemical binding]; other site
370569001745	NADPH bind site [chemical binding]; other site
370569001746	bacteriocin biosynthesis cyclodehydratase, SagC family; Region: cyclo_dehy_ocin; TIGR03603
370569001747	Uncharacterized conserved protein [Function unknown]; Region: COG1944; cl09146
370569001748	YcaO-like family; Region: YcaO; pfam02624
370569001749	CAAX protease self-immunity; Region: Abi; cl00558
370569001750	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
370569001751	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569001752	Walker A/P-loop; other site
370569001753	ATP binding site [chemical binding]; other site
370569001754	Q-loop/lid; other site
370569001755	ABC transporter signature motif; other site
370569001756	Walker B; other site
370569001757	D-loop; other site
370569001758	H-loop/switch region; other site
370569001759	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
370569001760	ABC-2 type transporter; Region: ABC2_membrane; cl11417
370569001761	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
370569001762	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
370569001763	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
370569001764	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
370569001765	generic binding surface II; other site
370569001766	generic binding surface I; other site
370569001767	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
370569001768	generic binding surface II; other site
370569001769	generic binding surface I; other site
370569001770	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
370569001771	putative catalytic site [active]
370569001772	putative metal binding site [ion binding]; other site
370569001773	putative phosphate binding site [ion binding]; other site
370569001774	QueT transporter; Region: QueT; cl01932
370569001775	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
370569001776	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
370569001777	nucleotide binding pocket [chemical binding]; other site
370569001778	K-X-D-G motif; other site
370569001779	catalytic site [active]
370569001780	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
370569001781	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
370569001782	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
370569001783	Dimer interface [polypeptide binding]; other site
370569001784	BRCT sequence motif; other site
370569001785	putative lipid kinase; Reviewed; Region: PRK13055
370569001786	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
370569001787	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
370569001788	ATP synthase subunit C; Region: ATP-synt_C; cl00466
370569001789	ATP synthase A chain; Region: ATP-synt_A; cl00413
370569001790	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
370569001791	Plant ATP synthase F0; Region: YMF19; cl07975
370569001792	Plant ATP synthase F0; Region: YMF19; cl07975
370569001793	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
370569001794	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
370569001795	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
370569001796	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
370569001797	beta subunit interaction interface [polypeptide binding]; other site
370569001798	Walker A motif; other site
370569001799	ATP binding site [chemical binding]; other site
370569001800	Walker B motif; other site
370569001801	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
370569001802	ATP synthase; Region: ATP-synt; cl00365
370569001803	F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422
370569001804	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
370569001805	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
370569001806	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
370569001807	alpha subunit interaction interface [polypeptide binding]; other site
370569001808	Walker A motif; other site
370569001809	ATP binding site [chemical binding]; other site
370569001810	Walker B motif; other site
370569001811	inhibitor binding site; inhibition site
370569001812	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
370569001813	ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063
370569001814	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
370569001815	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
370569001816	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
370569001817	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
370569001818	hinge; other site
370569001819	active site
370569001820	DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772
370569001821	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
370569001822	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
370569001823	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
370569001824	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
370569001825	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
370569001826	dimer interface [polypeptide binding]; other site
370569001827	motif 1; other site
370569001828	active site
370569001829	motif 2; other site
370569001830	motif 3; other site
370569001831	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
370569001832	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
370569001833	putative tRNA-binding site [nucleotide binding]; other site
370569001834	B3/4 domain; Region: B3_4; cl11458
370569001835	tRNA synthetase B5 domain; Region: B5; cl08394
370569001836	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
370569001837	dimer interface [polypeptide binding]; other site
370569001838	motif 1; other site
370569001839	motif 3; other site
370569001840	motif 2; other site
370569001841	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
370569001842	OsmC-like protein; Region: OsmC; cl00767
370569001843	Protein of unknown function (DUF1722); Region: DUF1722; cl01284
370569001844	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
370569001845	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
370569001846	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
370569001847	Walker A/P-loop; other site
370569001848	ATP binding site [chemical binding]; other site
370569001849	Q-loop/lid; other site
370569001850	ABC transporter signature motif; other site
370569001851	Walker B; other site
370569001852	D-loop; other site
370569001853	H-loop/switch region; other site
370569001854	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988
370569001855	ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774
370569001856	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
370569001857	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
370569001858	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569001859	Family description; Region: UvrD_C_2; cl15862
370569001860	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
370569001861	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
370569001862	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
370569001863	substrate binding pocket [chemical binding]; other site
370569001864	membrane-bound complex binding site; other site
370569001865	hinge residues; other site
370569001866	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
370569001867	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
370569001868	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
370569001869	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
370569001870	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
370569001871	Transposase [DNA replication, recombination, and repair]; Region: COG5433
370569001872	DNA primase; Validated; Region: dnaG; PRK05667
370569001873	CHC2 zinc finger; Region: zf-CHC2; cl15369
370569001874	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
370569001875	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
370569001876	active site
370569001877	metal binding site [ion binding]; metal-binding site
370569001878	interdomain interaction site; other site
370569001879	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
370569001880	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
370569001881	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
370569001882	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
370569001883	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
370569001884	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
370569001885	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
370569001886	DNA binding residues [nucleotide binding]
370569001887	Domain of unknown function DUF59; Region: DUF59; cl00941
370569001888	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
370569001889	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
370569001890	NADP binding site [chemical binding]; other site
370569001891	active site
370569001892	putative substrate binding site [chemical binding]; other site
370569001893	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
370569001894	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
370569001895	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
370569001896	Probable Catalytic site; other site
370569001897	ABC-2 type transporter; Region: ABC2_membrane; cl11417
370569001898	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
370569001899	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220
370569001900	Walker A/P-loop; other site
370569001901	ATP binding site [chemical binding]; other site
370569001902	Q-loop/lid; other site
370569001903	ABC transporter signature motif; other site
370569001904	Walker B; other site
370569001905	D-loop; other site
370569001906	H-loop/switch region; other site
370569001907	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
370569001908	active site
370569001909	Rhamnan synthesis protein F; Region: RgpF; cl01529
370569001910	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
370569001911	Sulfatase; Region: Sulfatase; cl10460
370569001912	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
370569001913	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
370569001914	Ligand binding site; other site
370569001915	Putative Catalytic site; other site
370569001916	DXD motif; other site
370569001917	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
370569001918	MatE; Region: MatE; cl10513
370569001919	Predicted membrane protein [Function unknown]; Region: COG4713
370569001920	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
370569001921	peptidase T; Region: peptidase-T; TIGR01882
370569001922	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
370569001923	metal binding site [ion binding]; metal-binding site
370569001924	dimer interface [polypeptide binding]; other site
370569001925	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
370569001926	cytidylate kinase; Provisional; Region: cmk; PRK00023
370569001927	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
370569001928	CMP-binding site; other site
370569001929	The sites determining sugar specificity; other site
370569001930	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
370569001931	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
370569001932	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
370569001933	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
370569001934	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
370569001935	23S rRNA binding site [nucleotide binding]; other site
370569001936	L21 binding site [polypeptide binding]; other site
370569001937	L13 binding site [polypeptide binding]; other site
370569001938	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
370569001939	Sulfatase; Region: Sulfatase; cl10460
370569001940	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
370569001941	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
370569001942	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
370569001943	3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093
370569001944	active site
370569001945	catalytic residue [active]
370569001946	dimer interface [polypeptide binding]; other site
370569001947	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
370569001948	Tetramer interface [polypeptide binding]; other site
370569001949	active site
370569001950	FMN-binding site [chemical binding]; other site
370569001951	Protein of unknown function (DUF964); Region: DUF964; cl01483
370569001952	glutathione reductase; Validated; Region: PRK06116
370569001953	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
370569001954	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
370569001955	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
370569001956	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
370569001957	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
370569001958	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
370569001959	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
370569001960	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
370569001961	catalytic residue [active]
370569001962	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
370569001963	THUMP domain; Region: THUMP; cl12076
370569001964	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
370569001965	Ligand Binding Site [chemical binding]; other site
370569001966	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
370569001967	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
370569001968	putative active site [active]
370569001969	putative metal binding site [ion binding]; other site
370569001970	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
370569001971	Helix-turn-helix domains; Region: HTH; cl00088
370569001972	Integrase core domain; Region: rve; cl01316
370569001973	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
370569001974	Protein of unknown function (DUF464); Region: DUF464; cl01080
370569001975	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
370569001976	Transcriptional regulator [Transcription]; Region: LysR; COG0583
370569001977	Helix-turn-helix domains; Region: HTH; cl00088
370569001978	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
370569001979	dimerization interface [polypeptide binding]; other site
370569001980	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
370569001981	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
370569001982	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
370569001983	RNA binding surface [nucleotide binding]; other site
370569001984	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
370569001985	active site
370569001986	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
370569001987	active site
370569001988	uracil transporter; Provisional; Region: PRK10720
370569001989	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
370569001990	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
370569001991	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
370569001992	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569001993	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
370569001994	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
370569001995	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
370569001996	catalytic site [active]
370569001997	subunit interface [polypeptide binding]; other site
370569001998	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
370569001999	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
370569002000	ATP-grasp domain; Region: ATP-grasp_4; cl03087
370569002001	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
370569002002	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
370569002003	ATP-grasp domain; Region: ATP-grasp_4; cl03087
370569002004	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
370569002005	IMP binding site; other site
370569002006	dimer interface [polypeptide binding]; other site
370569002007	interdomain contacts; other site
370569002008	partial ornithine binding site; other site
370569002009	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
370569002010	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
370569002011	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
370569002012	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
370569002013	Walker A/P-loop; other site
370569002014	ATP binding site [chemical binding]; other site
370569002015	Q-loop/lid; other site
370569002016	ABC transporter signature motif; other site
370569002017	Walker B; other site
370569002018	D-loop; other site
370569002019	H-loop/switch region; other site
370569002020	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
370569002021	FtsX-like permease family; Region: FtsX; cl15850
370569002022	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
370569002023	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
370569002024	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
370569002025	putative active site [active]
370569002026	catalytic site [active]
370569002027	putative metal binding site [ion binding]; other site
370569002028	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
370569002029	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
370569002030	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
370569002031	Transposase domain (DUF772); Region: DUF772; cl15789
370569002032	Transposase domain (DUF772); Region: DUF772; cl15789
370569002033	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
370569002034	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
370569002035	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
370569002036	Cation efflux family; Region: Cation_efflux; cl00316
370569002037	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
370569002038	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
370569002039	RimM N-terminal domain; Region: RimM; pfam01782
370569002040	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
370569002041	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
370569002042	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
370569002043	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569002044	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
370569002045	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
370569002046	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
370569002047	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
370569002048	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569002049	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
370569002050	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
370569002051	Helix-turn-helix domains; Region: HTH; cl00088
370569002052	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
370569002053	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
370569002054	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
370569002055	putative substrate binding site [chemical binding]; other site
370569002056	putative ATP binding site [chemical binding]; other site
370569002057	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
370569002058	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
370569002059	active site
370569002060	phosphorylation site [posttranslational modification]
370569002061	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
370569002062	active site
370569002063	P-loop; other site
370569002064	phosphorylation site [posttranslational modification]
370569002065	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
370569002066	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
370569002067	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
370569002068	Integrase core domain; Region: rve; cl01316
370569002069	Integrase core domain; Region: rve_3; cl15866
370569002070	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
370569002071	Mac 1; Region: Mac-1; pfam09028
370569002072	Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335
370569002073	multimer interface [polypeptide binding]; other site
370569002074	Protein of unknown function (DUF1149); Region: DUF1149; cl11551
370569002075	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
370569002076	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
370569002077	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
370569002078	active site
370569002079	NTP binding site [chemical binding]; other site
370569002080	metal binding triad [ion binding]; metal-binding site
370569002081	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
370569002082	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
370569002083	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
370569002084	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569002085	Walker A/P-loop; other site
370569002086	ATP binding site [chemical binding]; other site
370569002087	Q-loop/lid; other site
370569002088	ABC transporter signature motif; other site
370569002089	Walker B; other site
370569002090	D-loop; other site
370569002091	H-loop/switch region; other site
370569002092	ABC transporter; Region: ABC_tran_2; pfam12848
370569002093	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
370569002094	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569002095	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
370569002096	active site
370569002097	catalytic residues [active]
370569002098	metal binding site [ion binding]; metal-binding site
370569002099	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
370569002100	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
370569002101	putative active site [active]
370569002102	putative metal binding site [ion binding]; other site
370569002103	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
370569002104	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
370569002105	synthetase active site [active]
370569002106	NTP binding site [chemical binding]; other site
370569002107	metal binding site [ion binding]; metal-binding site
370569002108	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
370569002109	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370569002110	active site
370569002111	phosphorylation site [posttranslational modification]
370569002112	intermolecular recognition site; other site
370569002113	dimerization interface [polypeptide binding]; other site
370569002114	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
370569002115	DNA binding site [nucleotide binding]
370569002116	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
370569002117	dimer interface [polypeptide binding]; other site
370569002118	phosphorylation site [posttranslational modification]
370569002119	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370569002120	ATP binding site [chemical binding]; other site
370569002121	Mg2+ binding site [ion binding]; other site
370569002122	G-X-G motif; other site
370569002123	mevalonate kinase; Region: mevalon_kin; TIGR00549
370569002124	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
370569002125	diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240
370569002126	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
370569002127	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
370569002128	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
370569002129	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
370569002130	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
370569002131	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
370569002132	homotetramer interface [polypeptide binding]; other site
370569002133	FMN binding site [chemical binding]; other site
370569002134	homodimer contacts [polypeptide binding]; other site
370569002135	putative active site [active]
370569002136	putative substrate binding site [chemical binding]; other site
370569002137	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
370569002138	homodimer interface [polypeptide binding]; other site
370569002139	catalytic residues [active]
370569002140	NAD binding site [chemical binding]; other site
370569002141	substrate binding pocket [chemical binding]; other site
370569002142	flexible flap; other site
370569002143	'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827
370569002144	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
370569002145	dimer interface [polypeptide binding]; other site
370569002146	active site
370569002147	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
370569002148	dimerization interface [polypeptide binding]; other site
370569002149	active site
370569002150	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
370569002151	folate binding site [chemical binding]; other site
370569002152	NADP+ binding site [chemical binding]; other site
370569002153	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
370569002154	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
370569002155	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370569002156	Walker A motif; other site
370569002157	ATP binding site [chemical binding]; other site
370569002158	Walker B motif; other site
370569002159	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
370569002160	Predicted GTPase [General function prediction only]; Region: COG0218
370569002161	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
370569002162	G1 box; other site
370569002163	GTP/Mg2+ binding site [chemical binding]; other site
370569002164	Switch I region; other site
370569002165	G2 box; other site
370569002166	G3 box; other site
370569002167	Switch II region; other site
370569002168	G4 box; other site
370569002169	G5 box; other site
370569002170	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370569002171	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
370569002172	Walker A motif; other site
370569002173	ATP binding site [chemical binding]; other site
370569002174	Walker B motif; other site
370569002175	arginine finger; other site
370569002176	UvrB/uvrC motif; Region: UVR; pfam02151
370569002177	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370569002178	Walker A motif; other site
370569002179	ATP binding site [chemical binding]; other site
370569002180	Walker B motif; other site
370569002181	arginine finger; other site
370569002182	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
370569002183	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
370569002184	tetramer (dimer of dimers) interface [polypeptide binding]; other site
370569002185	active site
370569002186	dimer interface [polypeptide binding]; other site
370569002187	Sulfatase; Region: Sulfatase; cl10460
370569002188	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
370569002189	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
370569002190	ArsC family; Region: ArsC; pfam03960
370569002191	catalytic residues [active]
370569002192	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
370569002193	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
370569002194	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
370569002195	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873
370569002196	Transcriptional regulator [Transcription]; Region: LysR; COG0583
370569002197	Helix-turn-helix domains; Region: HTH; cl00088
370569002198	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
370569002199	dimerization interface [polypeptide binding]; other site
370569002200	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
370569002201	active site
370569002202	dimer interface [polypeptide binding]; other site
370569002203	orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455
370569002204	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
370569002205	active site
370569002206	amidase; Provisional; Region: PRK06529
370569002207	Amidase; Region: Amidase; cl11426
370569002208	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
370569002209	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
370569002210	substrate binding pocket [chemical binding]; other site
370569002211	membrane-bound complex binding site; other site
370569002212	hinge residues; other site
370569002213	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569002214	dimer interface [polypeptide binding]; other site
370569002215	conserved gate region; other site
370569002216	putative PBP binding loops; other site
370569002217	ABC-ATPase subunit interface; other site
370569002218	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
370569002219	ligand binding site [chemical binding]; other site
370569002220	active site
370569002221	UGI interface [polypeptide binding]; other site
370569002222	catalytic site [active]
370569002223	dihydroorotase; Validated; Region: pyrC; PRK09357
370569002224	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
370569002225	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
370569002226	active site
370569002227	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
370569002228	DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058
370569002229	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
370569002230	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
370569002231	anchoring element; other site
370569002232	dimer interface [polypeptide binding]; other site
370569002233	ATP binding site [chemical binding]; other site
370569002234	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
370569002235	active site
370569002236	putative metal-binding site [ion binding]; other site
370569002237	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
370569002238	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
370569002239	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
370569002240	CAP-like domain; other site
370569002241	active site
370569002242	primary dimer interface [polypeptide binding]; other site
370569002243	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
370569002244	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
370569002245	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
370569002246	homodimer interface [polypeptide binding]; other site
370569002247	substrate-cofactor binding pocket; other site
370569002248	catalytic residue [active]
370569002249	Transposase domain (DUF772); Region: DUF772; cl15789
370569002250	Transposase domain (DUF772); Region: DUF772; cl15789
370569002251	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
370569002252	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
370569002253	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
370569002254	RNA binding site [nucleotide binding]; other site
370569002255	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
370569002256	RNA binding site [nucleotide binding]; other site
370569002257	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
370569002258	RNA binding site [nucleotide binding]; other site
370569002259	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692
370569002260	RNA binding site [nucleotide binding]; other site
370569002261	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
370569002262	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
370569002263	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
370569002264	active site residue [active]
370569002265	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
370569002266	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
370569002267	dimer interface [polypeptide binding]; other site
370569002268	N-terminal domain interface [polypeptide binding]; other site
370569002269	substrate binding pocket (H-site) [chemical binding]; other site
370569002270	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
370569002271	gating phenylalanine in ion channel; other site
370569002272	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569002273	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
370569002274	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
370569002275	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
370569002276	HflX GTPase family; Region: HflX; cd01878
370569002277	G1 box; other site
370569002278	GTP/Mg2+ binding site [chemical binding]; other site
370569002279	Switch I region; other site
370569002280	G2 box; other site
370569002281	G3 box; other site
370569002282	Switch II region; other site
370569002283	G4 box; other site
370569002284	G5 box; other site
370569002285	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
370569002286	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
370569002287	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
370569002288	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569002289	NAD(P) binding site [chemical binding]; other site
370569002290	active site
370569002291	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
370569002292	DHH family; Region: DHH; pfam01368
370569002293	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538
370569002294	Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503
370569002295	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
370569002296	active site
370569002297	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
370569002298	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
370569002299	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
370569002300	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
370569002301	minor groove reading motif; other site
370569002302	helix-hairpin-helix signature motif; other site
370569002303	substrate binding pocket [chemical binding]; other site
370569002304	active site
370569002305	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
370569002306	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569002307	Uncharacterized conserved protein [Function unknown]; Region: COG0327
370569002308	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
370569002309	FAD dependent oxidoreductase; Region: DAO; pfam01266
370569002310	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569002311	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
370569002312	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
370569002313	substrate binding site; other site
370569002314	tetramer interface; other site
370569002315	Cupin domain; Region: Cupin_2; cl09118
370569002316	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
370569002317	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
370569002318	NAD binding site [chemical binding]; other site
370569002319	substrate binding site [chemical binding]; other site
370569002320	homodimer interface [polypeptide binding]; other site
370569002321	active site
370569002322	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
370569002323	Int/Topo IB signature motif; other site
370569002324	Domain of unknown function (DUF955); Region: DUF955; cl01076
370569002325	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370569002326	salt bridge; other site
370569002327	non-specific DNA binding site [nucleotide binding]; other site
370569002328	sequence-specific DNA binding site [nucleotide binding]; other site
370569002329	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370569002330	non-specific DNA binding site [nucleotide binding]; other site
370569002331	salt bridge; other site
370569002332	sequence-specific DNA binding site [nucleotide binding]; other site
370569002333	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
370569002334	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370569002335	non-specific DNA binding site [nucleotide binding]; other site
370569002336	salt bridge; other site
370569002337	sequence-specific DNA binding site [nucleotide binding]; other site
370569002338	Siphovirus Gp157; Region: Sipho_Gp157; pfam05565
370569002339	phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618
370569002340	AAA domain; Region: AAA_24; pfam13479
370569002341	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569002342	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
370569002343	nucleotide binding region [chemical binding]; other site
370569002344	ATP-binding site [chemical binding]; other site
370569002345	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
370569002346	Protein of unknown function (DUF669); Region: DUF669; pfam05037
370569002347	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
370569002348	polymerase nucleotide-binding site; other site
370569002349	DNA-binding residues [nucleotide binding]; DNA binding site
370569002350	nucleotide binding site [chemical binding]; other site
370569002351	primase nucleotide-binding site [nucleotide binding]; other site
370569002352	Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362
370569002353	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
370569002354	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
370569002355	Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753
370569002356	YopX protein; Region: YopX; cl09859
370569002357	Protein of unknown function (DUF1642); Region: DUF1642; pfam07852
370569002358	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
370569002359	Bacteriophage CII protein; Region: Phage_CII; pfam05269
370569002360	Phage terminase large subunit; Region: Terminase_3; cl12054
370569002361	Terminase-like family; Region: Terminase_6; pfam03237
370569002362	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
370569002363	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
370569002364	NAD+--asparagine ADP-ribosyltransferase [Signal transduction mechanisms]; Region: COG5585
370569002365	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
370569002366	Domain of unknown function (DUF4355); Region: DUF4355; pfam14265
370569002367	HeH/LEM domain; Region: HeH; pfam12949
370569002368	Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049
370569002369	Phage major tail protein 2; Region: Phage_tail_2; cl11463
370569002370	IMV membrane protein; Provisional; Region: PHA03048
370569002371	phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760
370569002372	Phage-related protein [Function unknown]; Region: COG5412
370569002373	Phage-related protein [Function unknown]; Region: COG4722; cl15832
370569002374	Phage tail protein; Region: Sipho_tail; pfam05709
370569002375	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
370569002376	NlpC/P60 family; Region: NLPC_P60; cl11438
370569002377	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
370569002378	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
370569002379	Siphovirus protein of unknown function (DUF859); Region: DUF859; pfam05895
370569002380	baseplate wedge subunit and tail pin; Provisional; Region: 10; PHA02582
370569002381	Protein of unknown function (DUF1366); Region: DUF1366; pfam07104
370569002382	Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890
370569002383	NlpC/P60 family; Region: NLPC_P60; cl11438
370569002384	Bacterial SH3 domain; Region: SH3_3; cl02551
370569002385	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
370569002386	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
370569002387	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
370569002388	putative active site [active]
370569002389	nucleotide binding site [chemical binding]; other site
370569002390	nudix motif; other site
370569002391	putative metal binding site [ion binding]; other site
370569002392	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
370569002393	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
370569002394	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
370569002395	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
370569002396	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
370569002397	Domain of unknown function (DUF814); Region: DUF814; pfam05670
370569002398	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
370569002399	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
370569002400	zinc binding site [ion binding]; other site
370569002401	putative ligand binding site [chemical binding]; other site
370569002402	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
370569002403	TM-ABC transporter signature motif; other site
370569002404	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
370569002405	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569002406	Walker A/P-loop; other site
370569002407	ATP binding site [chemical binding]; other site
370569002408	Q-loop/lid; other site
370569002409	ABC transporter signature motif; other site
370569002410	Walker B; other site
370569002411	D-loop; other site
370569002412	H-loop/switch region; other site
370569002413	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
370569002414	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
370569002415	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
370569002416	Predicted esterase [General function prediction only]; Region: COG0627
370569002417	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
370569002418	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
370569002419	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
370569002420	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
370569002421	ABC transporter; Region: ABC_tran_2; pfam12848
370569002422	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
370569002423	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
370569002424	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
370569002425	tetramer interface [polypeptide binding]; other site
370569002426	TPP-binding site [chemical binding]; other site
370569002427	heterodimer interface [polypeptide binding]; other site
370569002428	phosphorylation loop region [posttranslational modification]
370569002429	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
370569002430	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
370569002431	alpha subunit interface [polypeptide binding]; other site
370569002432	TPP binding site [chemical binding]; other site
370569002433	heterodimer interface [polypeptide binding]; other site
370569002434	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
370569002435	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
370569002436	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
370569002437	E3 interaction surface; other site
370569002438	lipoyl attachment site [posttranslational modification]; other site
370569002439	e3 binding domain; Region: E3_binding; pfam02817
370569002440	e3 binding domain; Region: E3_binding; pfam02817
370569002441	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
370569002442	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
370569002443	E3 interaction surface; other site
370569002444	lipoyl attachment site [posttranslational modification]; other site
370569002445	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
370569002446	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
370569002447	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
370569002448	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
370569002449	substrate binding site [chemical binding]; other site
370569002450	catalytic residues [active]
370569002451	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
370569002452	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
370569002453	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
370569002454	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
370569002455	catalytic triad [active]
370569002456	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
370569002457	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
370569002458	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
370569002459	Uncharacterized conserved protein [Function unknown]; Region: COG1624
370569002460	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
370569002461	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
370569002462	YbbR-like protein; Region: YbbR; pfam07949
370569002463	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
370569002464	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
370569002465	active site
370569002466	substrate binding site [chemical binding]; other site
370569002467	metal binding site [ion binding]; metal-binding site
370569002468	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
370569002469	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370569002470	FeS/SAM binding site; other site
370569002471	HemN C-terminal domain; Region: HemN_C; pfam06969
370569002472	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
370569002473	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
370569002474	active site
370569002475	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
370569002476	active site 2 [active]
370569002477	active site 1 [active]
370569002478	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
370569002479	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
370569002480	active site
370569002481	motif I; other site
370569002482	motif II; other site
370569002483	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
370569002484	Protein of unknown function (DUF1461); Region: DUF1461; cl01862
370569002485	Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms]; Region: COG3513
370569002486	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
370569002487	CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643
370569002488	CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720
370569002489	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
370569002490	CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866
370569002491	CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd09758
370569002492	Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335
370569002493	active site
370569002494	GTP-binding protein LepA; Provisional; Region: PRK05433
370569002495	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
370569002496	G1 box; other site
370569002497	putative GEF interaction site [polypeptide binding]; other site
370569002498	GTP/Mg2+ binding site [chemical binding]; other site
370569002499	Switch I region; other site
370569002500	G2 box; other site
370569002501	G3 box; other site
370569002502	Switch II region; other site
370569002503	G4 box; other site
370569002504	G5 box; other site
370569002505	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
370569002506	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
370569002507	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
370569002508	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
370569002509	Gram positive anchor; Region: Gram_pos_anchor; cl15427
370569002510	methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841
370569002511	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
370569002512	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
370569002513	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
370569002514	active pocket/dimerization site; other site
370569002515	active site
370569002516	phosphorylation site [posttranslational modification]
370569002517	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
370569002518	active site
370569002519	phosphorylation site [posttranslational modification]
370569002520	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
370569002521	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
370569002522	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
370569002523	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
370569002524	Histidine kinase; Region: His_kinase; pfam06580
370569002525	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370569002526	ATP binding site [chemical binding]; other site
370569002527	Mg2+ binding site [ion binding]; other site
370569002528	G-X-G motif; other site
370569002529	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370569002530	Response regulator receiver domain; Region: Response_reg; pfam00072
370569002531	active site
370569002532	phosphorylation site [posttranslational modification]
370569002533	intermolecular recognition site; other site
370569002534	dimerization interface [polypeptide binding]; other site
370569002535	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
370569002536	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
370569002537	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
370569002538	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
370569002539	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
370569002540	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
370569002541	NAD(P) binding site [chemical binding]; other site
370569002542	catalytic residues [active]
370569002543	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
370569002544	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
370569002545	GIY-YIG motif/motif A; other site
370569002546	active site
370569002547	catalytic site [active]
370569002548	putative DNA binding site [nucleotide binding]; other site
370569002549	metal binding site [ion binding]; metal-binding site
370569002550	UvrB/uvrC motif; Region: UVR; pfam02151
370569002551	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
370569002552	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
370569002553	dimer interface [polypeptide binding]; other site
370569002554	FMN binding site [chemical binding]; other site
370569002555	dipeptidase PepV; Reviewed; Region: PRK07318
370569002556	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
370569002557	active site
370569002558	metal binding site [ion binding]; metal-binding site
370569002559	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
370569002560	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
370569002561	trmE is a tRNA modification GTPase; Region: trmE; cd04164
370569002562	G1 box; other site
370569002563	GTP/Mg2+ binding site [chemical binding]; other site
370569002564	Switch I region; other site
370569002565	G2 box; other site
370569002566	Switch II region; other site
370569002567	G3 box; other site
370569002568	G4 box; other site
370569002569	G5 box; other site
370569002570	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
370569002571	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
370569002572	23S rRNA interface [nucleotide binding]; other site
370569002573	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
370569002574	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
370569002575	core dimer interface [polypeptide binding]; other site
370569002576	L10 interface [polypeptide binding]; other site
370569002577	L11 interface [polypeptide binding]; other site
370569002578	putative EF-Tu interaction site [polypeptide binding]; other site
370569002579	putative EF-G interaction site [polypeptide binding]; other site
370569002580	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
370569002581	cofactor binding site; other site
370569002582	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
370569002583	Lantibiotic streptin immunity protein; Region: Streptin-Immun; pfam11083
370569002584	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
370569002585	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370569002586	active site
370569002587	phosphorylation site [posttranslational modification]
370569002588	intermolecular recognition site; other site
370569002589	dimerization interface [polypeptide binding]; other site
370569002590	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
370569002591	DNA binding site [nucleotide binding]
370569002592	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
370569002593	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370569002594	ATP binding site [chemical binding]; other site
370569002595	Mg2+ binding site [ion binding]; other site
370569002596	G-X-G motif; other site
370569002597	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
370569002598	The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export.  They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins.  The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228
370569002599	Walker A/P-loop; other site
370569002600	ATP binding site [chemical binding]; other site
370569002601	Q-loop/lid; other site
370569002602	ABC transporter signature motif; other site
370569002603	Walker B; other site
370569002604	D-loop; other site
370569002605	H-loop/switch region; other site
370569002606	Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147
370569002607	LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793
370569002608	active site
370569002609	zinc binding site [ion binding]; other site
370569002610	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
370569002611	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
370569002612	SpaB C-terminal domain; Region: SpaB_C; cl14828
370569002613	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
370569002614	The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance.  Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis.  The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268
370569002615	Walker A/P-loop; other site
370569002616	ATP binding site [chemical binding]; other site
370569002617	Q-loop/lid; other site
370569002618	ABC transporter signature motif; other site
370569002619	Walker B; other site
370569002620	D-loop; other site
370569002621	H-loop/switch region; other site
370569002622	ABC-2 type transporter; Region: ABC2_membrane; cl11417
370569002623	ABC-2 type transporter; Region: ABC2_membrane; cl11417
370569002624	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370569002625	non-specific DNA binding site [nucleotide binding]; other site
370569002626	salt bridge; other site
370569002627	sequence-specific DNA binding site [nucleotide binding]; other site
370569002628	Domain of unknown function (DUF3173); Region: DUF3173; pfam11372
370569002629	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
370569002630	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
370569002631	DNA binding site [nucleotide binding]
370569002632	Int/Topo IB signature motif; other site
370569002633	active site
370569002634	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
370569002635	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
370569002636	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
370569002637	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
370569002638	putative active site [active]
370569002639	putative metal binding site [ion binding]; other site
370569002640	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
370569002641	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
370569002642	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
370569002643	homodecamer interface [polypeptide binding]; other site
370569002644	GTP cyclohydrolase I; Provisional; Region: PLN03044
370569002645	active site
370569002646	putative catalytic site residues [active]
370569002647	zinc binding site [ion binding]; other site
370569002648	GTP-CH-I/GFRP interaction surface; other site
370569002649	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
370569002650	dihydropteroate synthase; Region: DHPS; TIGR01496
370569002651	substrate binding pocket [chemical binding]; other site
370569002652	dimer interface [polypeptide binding]; other site
370569002653	inhibitor binding site; inhibition site
370569002654	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
370569002655	homooctamer interface [polypeptide binding]; other site
370569002656	active site
370569002657	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
370569002658	catalytic center binding site [active]
370569002659	ATP binding site [chemical binding]; other site
370569002660	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
370569002661	FAD binding domain; Region: FAD_binding_4; pfam01565
370569002662	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
370569002663	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
370569002664	PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D.  PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300
370569002665	Walker A/P-loop; other site
370569002666	ATP binding site [chemical binding]; other site
370569002667	Q-loop/lid; other site
370569002668	ABC transporter signature motif; other site
370569002669	Walker B; other site
370569002670	D-loop; other site
370569002671	H-loop/switch region; other site
370569002672	TOBE domain; Region: TOBE_2; cl01440
370569002673	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
370569002674	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569002675	dimer interface [polypeptide binding]; other site
370569002676	conserved gate region; other site
370569002677	putative PBP binding loops; other site
370569002678	ABC-ATPase subunit interface; other site
370569002679	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
370569002680	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569002681	dimer interface [polypeptide binding]; other site
370569002682	conserved gate region; other site
370569002683	putative PBP binding loops; other site
370569002684	ABC-ATPase subunit interface; other site
370569002685	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
370569002686	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
370569002687	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
370569002688	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370569002689	active site
370569002690	phosphorylation site [posttranslational modification]
370569002691	intermolecular recognition site; other site
370569002692	dimerization interface [polypeptide binding]; other site
370569002693	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
370569002694	2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386
370569002695	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
370569002696	Malic enzyme, N-terminal domain; Region: malic; pfam00390
370569002697	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
370569002698	putative NAD(P) binding site [chemical binding]; other site
370569002699	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
370569002700	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
370569002701	catalytic Zn binding site [ion binding]; other site
370569002702	structural Zn binding site [ion binding]; other site
370569002703	NAD(P) binding site [chemical binding]; other site
370569002704	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
370569002705	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
370569002706	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
370569002707	dimer interface [polypeptide binding]; other site
370569002708	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
370569002709	NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841
370569002710	active site
370569002711	catalytic triad [active]
370569002712	oxyanion hole [active]
370569002713	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
370569002714	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
370569002715	hypothetical protein; Reviewed; Region: PRK00024
370569002716	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
370569002717	MPN+ (JAMM) motif; other site
370569002718	Zinc-binding site [ion binding]; other site
370569002719	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
370569002720	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
370569002721	catalytic triad [active]
370569002722	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
370569002723	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
370569002724	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569002725	Putative amino acid metabolism; Region: DUF1831; pfam08866
370569002726	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
370569002727	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
370569002728	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
370569002729	catalytic residue [active]
370569002730	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458
370569002731	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
370569002732	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
370569002733	active site
370569002734	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
370569002735	putative active site [active]
370569002736	putative metal binding residues [ion binding]; other site
370569002737	signature motif; other site
370569002738	putative triphosphate binding site [ion binding]; other site
370569002739	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
370569002740	synthetase active site [active]
370569002741	NTP binding site [chemical binding]; other site
370569002742	metal binding site [ion binding]; metal-binding site
370569002743	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
370569002744	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
370569002745	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
370569002746	active site
370569002747	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
370569002748	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
370569002749	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
370569002750	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569002751	NAD(P) binding site [chemical binding]; other site
370569002752	active site
370569002753	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
370569002754	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569002755	Walker A/P-loop; other site
370569002756	ATP binding site [chemical binding]; other site
370569002757	Q-loop/lid; other site
370569002758	ABC transporter signature motif; other site
370569002759	Walker B; other site
370569002760	D-loop; other site
370569002761	H-loop/switch region; other site
370569002762	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569002763	dimer interface [polypeptide binding]; other site
370569002764	conserved gate region; other site
370569002765	ABC-ATPase subunit interface; other site
370569002766	NMT1-like family; Region: NMT1_2; cl15260
370569002767	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
370569002768	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
370569002769	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
370569002770	active site
370569002771	Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503
370569002772	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
370569002773	active site
370569002774	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
370569002775	xanthine permease; Region: pbuX; TIGR03173
370569002776	ApbE family; Region: ApbE; cl00643
370569002777	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
370569002778	active site 1 [active]
370569002779	dimer interface [polypeptide binding]; other site
370569002780	hexamer interface [polypeptide binding]; other site
370569002781	active site 2 [active]
370569002782	thymidine kinase; Provisional; Region: PRK04296
370569002783	peptide chain release factor 1; Validated; Region: prfA; PRK00591
370569002784	RF-1 domain; Region: RF-1; cl02875
370569002785	RF-1 domain; Region: RF-1; cl02875
370569002786	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
370569002787	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370569002788	S-adenosylmethionine binding site [chemical binding]; other site
370569002789	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
370569002790	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
370569002791	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
370569002792	Coenzyme A binding pocket [chemical binding]; other site
370569002793	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
370569002794	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
370569002795	dimer interface [polypeptide binding]; other site
370569002796	active site
370569002797	glycine-pyridoxal phosphate binding site [chemical binding]; other site
370569002798	folate binding site [chemical binding]; other site
370569002799	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
370569002800	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
370569002801	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
370569002802	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
370569002803	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569002804	Walker A/P-loop; other site
370569002805	ATP binding site [chemical binding]; other site
370569002806	Q-loop/lid; other site
370569002807	ABC transporter signature motif; other site
370569002808	Walker B; other site
370569002809	D-loop; other site
370569002810	H-loop/switch region; other site
370569002811	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
370569002812	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
370569002813	Glucan exporter ATP-binding protein.  In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor.  This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254
370569002814	Walker A/P-loop; other site
370569002815	ATP binding site [chemical binding]; other site
370569002816	Q-loop/lid; other site
370569002817	ABC transporter signature motif; other site
370569002818	Walker B; other site
370569002819	D-loop; other site
370569002820	H-loop/switch region; other site
370569002821	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
370569002822	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
370569002823	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
370569002824	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
370569002825	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
370569002826	tetramer (dimer of dimers) interface [polypeptide binding]; other site
370569002827	NAD binding site [chemical binding]; other site
370569002828	dimer interface [polypeptide binding]; other site
370569002829	substrate binding site [chemical binding]; other site
370569002830	DNA gyrase subunit A; Validated; Region: PRK05560
370569002831	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
370569002832	CAP-like domain; other site
370569002833	active site
370569002834	primary dimer interface [polypeptide binding]; other site
370569002835	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
370569002836	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
370569002837	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
370569002838	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
370569002839	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
370569002840	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
370569002841	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
370569002842	active site
370569002843	catalytic site [active]
370569002844	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
370569002845	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
370569002846	putative metal binding site [ion binding]; other site
370569002847	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
370569002848	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
370569002849	Haemolysin-III related; Region: HlyIII; cl03831
370569002850	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
370569002851	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
370569002852	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
370569002853	GTP/Mg2+ binding site [chemical binding]; other site
370569002854	G4 box; other site
370569002855	G5 box; other site
370569002856	G1 box; other site
370569002857	Switch I region; other site
370569002858	G2 box; other site
370569002859	G3 box; other site
370569002860	Switch II region; other site
370569002861	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
370569002862	RNA/DNA hybrid binding site [nucleotide binding]; other site
370569002863	active site
370569002864	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
370569002865	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
370569002866	DNA topoisomerase I; Validated; Region: PRK05582
370569002867	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
370569002868	active site
370569002869	interdomain interaction site; other site
370569002870	putative metal-binding site [ion binding]; other site
370569002871	nucleotide binding site [chemical binding]; other site
370569002872	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
370569002873	domain I; other site
370569002874	DNA binding groove [nucleotide binding]
370569002875	phosphate binding site [ion binding]; other site
370569002876	domain II; other site
370569002877	domain III; other site
370569002878	nucleotide binding site [chemical binding]; other site
370569002879	catalytic site [active]
370569002880	domain IV; other site
370569002881	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
370569002882	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
370569002883	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
370569002884	Helix-turn-helix domains; Region: HTH; cl00088
370569002885	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
370569002886	D-lactate dehydrogenase; Validated; Region: PRK08605
370569002887	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569002888	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
370569002889	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
370569002890	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569002891	oxaloacetate decarboxylase; Provisional; Region: PRK12581
370569002892	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
370569002893	active site
370569002894	catalytic residues [active]
370569002895	metal binding site [ion binding]; metal-binding site
370569002896	homodimer binding site [polypeptide binding]; other site
370569002897	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549
370569002898	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
370569002899	carboxyltransferase (CT) interaction site; other site
370569002900	biotinylation site [posttranslational modification]; other site
370569002901	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
370569002902	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
370569002903	Transcriptional regulators [Transcription]; Region: GntR; COG1802
370569002904	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
370569002905	DNA-binding site [nucleotide binding]; DNA binding site
370569002906	FCD domain; Region: FCD; cl11656
370569002907	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
370569002908	Citrate transporter; Region: CitMHS; pfam03600
370569002909	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549
370569002910	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
370569002911	carboxyltransferase (CT) interaction site; other site
370569002912	biotinylation site [posttranslational modification]; other site
370569002913	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
370569002914	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
370569002915	Malonate decarboxylase delta subunit (MdcD); Region: ACP; cl06082
370569002916	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
370569002917	Citrate lyase, alpha subunit (CitF); Region: CitF; pfam04223
370569002918	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
370569002919	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; cl01498
370569002920	oxaloacetate decarboxylase; Provisional; Region: PRK12331
370569002921	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
370569002922	active site
370569002923	catalytic residues [active]
370569002924	metal binding site [ion binding]; metal-binding site
370569002925	homodimer binding site [polypeptide binding]; other site
370569002926	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
370569002927	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
370569002928	putative active site [active]
370569002929	(T/H)XGH motif; other site
370569002930	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
370569002931	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
370569002932	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
370569002933	active site
370569002934	DNA binding site [nucleotide binding]
370569002935	Int/Topo IB signature motif; other site
370569002936	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
370569002937	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370569002938	non-specific DNA binding site [nucleotide binding]; other site
370569002939	salt bridge; other site
370569002940	sequence-specific DNA binding site [nucleotide binding]; other site
370569002941	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
370569002942	Catalytic site [active]
370569002943	signal recognition particle protein; Provisional; Region: PRK10867
370569002944	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
370569002945	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
370569002946	P loop; other site
370569002947	GTP binding site [chemical binding]; other site
370569002948	Signal peptide binding domain; Region: SRP_SPB; pfam02978
370569002949	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
370569002950	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
370569002951	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
370569002952	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
370569002953	DNA-binding site [nucleotide binding]; DNA binding site
370569002954	UTRA domain; Region: UTRA; cl01230
370569002955	GMP synthase; Reviewed; Region: guaA; PRK00074
370569002956	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
370569002957	AMP/PPi binding site [chemical binding]; other site
370569002958	candidate oxyanion hole; other site
370569002959	catalytic triad [active]
370569002960	potential glutamine specificity residues [chemical binding]; other site
370569002961	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
370569002962	ATP Binding subdomain [chemical binding]; other site
370569002963	Dimerization subdomain; other site
370569002964	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
370569002965	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
370569002966	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
370569002967	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
370569002968	ABC transporter; Region: ABC_tran_2; pfam12848
370569002969	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
370569002970	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
370569002971	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
370569002972	dimer interface [polypeptide binding]; other site
370569002973	pyridoxal binding site [chemical binding]; other site
370569002974	ATP binding site [chemical binding]; other site
370569002975	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
370569002976	DNA-binding site [nucleotide binding]; DNA binding site
370569002977	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
370569002978	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370569002979	homodimer interface [polypeptide binding]; other site
370569002980	ATP cone domain; Region: ATP-cone; pfam03477
370569002981	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
370569002982	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
370569002983	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
370569002984	putative active site [active]
370569002985	catalytic site [active]
370569002986	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
370569002987	putative active site [active]
370569002988	catalytic site [active]
370569002989	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
370569002990	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
370569002991	Potassium binding sites [ion binding]; other site
370569002992	Cesium cation binding sites [ion binding]; other site
370569002993	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
370569002994	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
370569002995	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
370569002996	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296
370569002997	Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906
370569002998	putative ADP-ribose binding site [chemical binding]; other site
370569002999	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
370569003000	lipoyl attachment site [posttranslational modification]; other site
370569003001	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
370569003002	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
370569003003	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
370569003004	putative active site [active]
370569003005	putative FMN binding site [chemical binding]; other site
370569003006	putative substrate binding site [chemical binding]; other site
370569003007	putative catalytic residue [active]
370569003008	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
370569003009	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
370569003010	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
370569003011	phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313
370569003012	Flavoprotein; Region: Flavoprotein; cl08021
370569003013	Predicted membrane protein [Function unknown]; Region: COG4684
370569003014	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
370569003015	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
370569003016	active site
370569003017	substrate binding site [chemical binding]; other site
370569003018	metal binding site [ion binding]; metal-binding site
370569003019	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
370569003020	TM-ABC transporter signature motif; other site
370569003021	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
370569003022	TM-ABC transporter signature motif; other site
370569003023	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
370569003024	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
370569003025	Walker A/P-loop; other site
370569003026	ATP binding site [chemical binding]; other site
370569003027	Q-loop/lid; other site
370569003028	ABC transporter signature motif; other site
370569003029	Walker B; other site
370569003030	D-loop; other site
370569003031	H-loop/switch region; other site
370569003032	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
370569003033	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
370569003034	ligand binding site [chemical binding]; other site
370569003035	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
370569003036	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
370569003037	active site
370569003038	catalytic motif [active]
370569003039	Zn binding site [ion binding]; other site
370569003040	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569003041	Methyltransferase domain; Region: Methyltransf_31; pfam13847
370569003042	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370569003043	S-adenosylmethionine binding site [chemical binding]; other site
370569003044	pantothenate kinase; Provisional; Region: PRK05439
370569003045	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025
370569003046	ATP-binding site [chemical binding]; other site
370569003047	CoA-binding site [chemical binding]; other site
370569003048	Mg2+-binding site [ion binding]; other site
370569003049	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
370569003050	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
370569003051	dimer interface [polypeptide binding]; other site
370569003052	phosphorylation site [posttranslational modification]
370569003053	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370569003054	ATP binding site [chemical binding]; other site
370569003055	Mg2+ binding site [ion binding]; other site
370569003056	G-X-G motif; other site
370569003057	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
370569003058	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370569003059	active site
370569003060	phosphorylation site [posttranslational modification]
370569003061	intermolecular recognition site; other site
370569003062	dimerization interface [polypeptide binding]; other site
370569003063	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
370569003064	DNA binding site [nucleotide binding]
370569003065	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
370569003066	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
370569003067	Zn binding site [ion binding]; other site
370569003068	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
370569003069	PhoU domain; Region: PhoU; pfam01895
370569003070	PhoU domain; Region: PhoU; pfam01895
370569003071	phosphate transporter ATP-binding protein; Provisional; Region: PRK14239
370569003072	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
370569003073	Walker A/P-loop; other site
370569003074	ATP binding site [chemical binding]; other site
370569003075	Q-loop/lid; other site
370569003076	ABC transporter signature motif; other site
370569003077	Walker B; other site
370569003078	D-loop; other site
370569003079	H-loop/switch region; other site
370569003080	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
370569003081	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
370569003082	Walker A/P-loop; other site
370569003083	ATP binding site [chemical binding]; other site
370569003084	Q-loop/lid; other site
370569003085	ABC transporter signature motif; other site
370569003086	Walker B; other site
370569003087	D-loop; other site
370569003088	H-loop/switch region; other site
370569003089	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
370569003090	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569003091	dimer interface [polypeptide binding]; other site
370569003092	conserved gate region; other site
370569003093	putative PBP binding loops; other site
370569003094	ABC-ATPase subunit interface; other site
370569003095	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569003096	dimer interface [polypeptide binding]; other site
370569003097	conserved gate region; other site
370569003098	putative PBP binding loops; other site
370569003099	ABC-ATPase subunit interface; other site
370569003100	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
370569003101	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
370569003102	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370569003103	S-adenosylmethionine binding site [chemical binding]; other site
370569003104	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283
370569003105	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
370569003106	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
370569003107	active site
370569003108	Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484
370569003109	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
370569003110	ArsC family; Region: ArsC; pfam03960
370569003111	putative catalytic residues [active]
370569003112	thiol/disulfide switch; other site
370569003113	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
370569003114	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
370569003115	active site
370569003116	Riboflavin kinase; Region: Flavokinase; cl03312
370569003117	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484
370569003118	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573
370569003119	RNA binding site [nucleotide binding]; other site
370569003120	active site
370569003121	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
370569003122	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
370569003123	Predicted membrane protein [Function unknown]; Region: COG4129
370569003124	Fusaric acid resistance protein-like; Region: FUSC_2; cl15844
370569003125	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
370569003126	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
370569003127	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
370569003128	FtsX-like permease family; Region: FtsX; cl15850
370569003129	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
370569003130	FtsX-like permease family; Region: FtsX; cl15850
370569003131	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
370569003132	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
370569003133	Walker A/P-loop; other site
370569003134	ATP binding site [chemical binding]; other site
370569003135	Q-loop/lid; other site
370569003136	ABC transporter signature motif; other site
370569003137	Walker B; other site
370569003138	D-loop; other site
370569003139	H-loop/switch region; other site
370569003140	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
370569003141	Helix-turn-helix domains; Region: HTH; cl00088
370569003142	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
370569003143	DNA-binding site [nucleotide binding]; DNA binding site
370569003144	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
370569003145	Asp23 family; Region: Asp23; cl00574
370569003146	CsbD-like; Region: CsbD; cl15799
370569003147	Asp23 family; Region: Asp23; cl00574
370569003148	Small integral membrane protein (DUF2273); Region: DUF2273; cl11575
370569003149	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
370569003150	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
370569003151	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569003152	Family description; Region: UvrD_C_2; cl15862
370569003153	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
370569003154	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
370569003155	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
370569003156	Cation efflux family; Region: Cation_efflux; cl00316
370569003157	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
370569003158	CAMP factor (Cfa); Region: CAMP_factor; pfam07373
370569003159	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
370569003160	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
370569003161	substrate binding pocket [chemical binding]; other site
370569003162	membrane-bound complex binding site; other site
370569003163	hinge residues; other site
370569003164	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
370569003165	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569003166	Walker A/P-loop; other site
370569003167	ATP binding site [chemical binding]; other site
370569003168	Q-loop/lid; other site
370569003169	ABC transporter signature motif; other site
370569003170	Walker B; other site
370569003171	D-loop; other site
370569003172	H-loop/switch region; other site
370569003173	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569003174	dimer interface [polypeptide binding]; other site
370569003175	conserved gate region; other site
370569003176	ABC-ATPase subunit interface; other site
370569003177	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
370569003178	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
370569003179	PhnA protein; Region: PhnA; pfam03831
370569003180	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
370569003181	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
370569003182	glutaminase active site [active]
370569003183	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
370569003184	dimer interface [polypeptide binding]; other site
370569003185	active site
370569003186	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
370569003187	dimer interface [polypeptide binding]; other site
370569003188	active site
370569003189	Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681
370569003190	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
370569003191	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
370569003192	pyruvate kinase; Provisional; Region: PRK05826
370569003193	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
370569003194	domain interfaces; other site
370569003195	active site
370569003196	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
370569003197	active site
370569003198	ADP/pyrophosphate binding site [chemical binding]; other site
370569003199	dimerization interface [polypeptide binding]; other site
370569003200	allosteric effector site; other site
370569003201	fructose-1,6-bisphosphate binding site; other site
370569003202	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279
370569003203	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
370569003204	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
370569003205	generic binding surface II; other site
370569003206	generic binding surface I; other site
370569003207	Predicted transcriptional regulators [Transcription]; Region: COG1725
370569003208	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
370569003209	DNA-binding site [nucleotide binding]; DNA binding site
370569003210	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
370569003211	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
370569003212	Walker A/P-loop; other site
370569003213	ATP binding site [chemical binding]; other site
370569003214	Q-loop/lid; other site
370569003215	ABC transporter signature motif; other site
370569003216	Walker B; other site
370569003217	D-loop; other site
370569003218	H-loop/switch region; other site
370569003219	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
370569003220	Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978
370569003221	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
370569003222	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
370569003223	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
370569003224	Transcriptional regulators [Transcription]; Region: PurR; COG1609
370569003225	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
370569003226	DNA binding site [nucleotide binding]
370569003227	domain linker motif; other site
370569003228	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
370569003229	putative dimerization interface [polypeptide binding]; other site
370569003230	putative ligand binding site [chemical binding]; other site
370569003231	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
370569003232	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
370569003233	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569003234	dimer interface [polypeptide binding]; other site
370569003235	conserved gate region; other site
370569003236	ABC-ATPase subunit interface; other site
370569003237	ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833
370569003238	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569003239	dimer interface [polypeptide binding]; other site
370569003240	conserved gate region; other site
370569003241	putative PBP binding loops; other site
370569003242	ABC-ATPase subunit interface; other site
370569003243	Transcriptional regulators [Transcription]; Region: PurR; COG1609
370569003244	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
370569003245	DNA binding site [nucleotide binding]
370569003246	domain linker motif; other site
370569003247	Predicted integral membrane protein [Function unknown]; Region: COG5521
370569003248	ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833
370569003249	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569003250	dimer interface [polypeptide binding]; other site
370569003251	conserved gate region; other site
370569003252	putative PBP binding loops; other site
370569003253	ABC-ATPase subunit interface; other site
370569003254	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569003255	dimer interface [polypeptide binding]; other site
370569003256	conserved gate region; other site
370569003257	putative PBP binding loops; other site
370569003258	ABC-ATPase subunit interface; other site
370569003259	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
370569003260	IPT domain (domain D) of cyclodextrin glycosyltransferase (CGTase) and similar enzymes. These enzymes are involved in the enzymatic hydrolysis of alpha-1,4 linkages of starch polymers and belong to the glycosyl hydrolase family 13. Most consist of three...; Region: IPT_CGTD; cd00604
370569003261	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347
370569003262	starch-binding site 2 [chemical binding]; other site
370569003263	starch-binding site 1 [chemical binding]; other site
370569003264	Alpha amylase catalytic domain found in maltogenic amylases, cyclodextrin glycosyltransferase, and related proteins; Region: AmyAc_AmyMalt_CGTase_like; cd11320
370569003265	Ca binding site [ion binding]; other site
370569003266	active site
370569003267	catalytic site [active]
370569003268	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
370569003269	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
370569003270	maltodextrin glucosidase; Provisional; Region: PRK10785
370569003271	homodimer interface [polypeptide binding]; other site
370569003272	Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893
370569003273	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
370569003274	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
370569003275	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
370569003276	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
370569003277	DltD N-terminal region; Region: DltD_N; pfam04915
370569003278	DltD central region; Region: DltD_M; pfam04918
370569003279	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
370569003280	Phosphopantetheine attachment site; Region: PP-binding; cl09936
370569003281	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
370569003282	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
370569003283	AMP-binding enzyme; Region: AMP-binding; cl15778
370569003284	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
370569003285	excinuclease ABC subunit B; Provisional; Region: PRK05298
370569003286	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
370569003287	ATP binding site [chemical binding]; other site
370569003288	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
370569003289	nucleotide binding region [chemical binding]; other site
370569003290	ATP-binding site [chemical binding]; other site
370569003291	Ultra-violet resistance protein B; Region: UvrB; pfam12344
370569003292	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
370569003293	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
370569003294	substrate binding pocket [chemical binding]; other site
370569003295	membrane-bound complex binding site; other site
370569003296	hinge residues; other site
370569003297	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
370569003298	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
370569003299	substrate binding pocket [chemical binding]; other site
370569003300	membrane-bound complex binding site; other site
370569003301	hinge residues; other site
370569003302	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569003303	dimer interface [polypeptide binding]; other site
370569003304	conserved gate region; other site
370569003305	putative PBP binding loops; other site
370569003306	ABC-ATPase subunit interface; other site
370569003307	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
370569003308	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
370569003309	Walker A/P-loop; other site
370569003310	ATP binding site [chemical binding]; other site
370569003311	Q-loop/lid; other site
370569003312	ABC transporter signature motif; other site
370569003313	Walker B; other site
370569003314	D-loop; other site
370569003315	H-loop/switch region; other site
370569003316	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
370569003317	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
370569003318	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
370569003319	hydrophobic ligand binding site; other site
370569003320	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
370569003321	active site
370569003322	methionine cluster; other site
370569003323	phosphorylation site [posttranslational modification]
370569003324	metal binding site [ion binding]; metal-binding site
370569003325	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
370569003326	active site
370569003327	P-loop; other site
370569003328	phosphorylation site [posttranslational modification]
370569003329	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
370569003330	Helix-turn-helix domains; Region: HTH; cl00088
370569003331	Helix-turn-helix domains; Region: HTH; cl00088
370569003332	PRD domain; Region: PRD; cl15445
370569003333	PRD domain; Region: PRD; cl15445
370569003334	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
370569003335	active site
370569003336	P-loop; other site
370569003337	phosphorylation site [posttranslational modification]
370569003338	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
370569003339	active site
370569003340	phosphorylation site [posttranslational modification]
370569003341	Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404
370569003342	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
370569003343	Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256
370569003344	GTPase CgtA; Reviewed; Region: obgE; PRK12297
370569003345	GTP1/OBG; Region: GTP1_OBG; pfam01018
370569003346	Obg GTPase; Region: Obg; cd01898
370569003347	G1 box; other site
370569003348	GTP/Mg2+ binding site [chemical binding]; other site
370569003349	Switch I region; other site
370569003350	G2 box; other site
370569003351	G3 box; other site
370569003352	Switch II region; other site
370569003353	G4 box; other site
370569003354	G5 box; other site
370569003355	Domain of unknown function (DUF1967); Region: DUF1967; cl07779
370569003356	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
370569003357	Helix-turn-helix domains; Region: HTH; cl00088
370569003358	HTH-like domain; Region: HTH_21; pfam13276
370569003359	Integrase core domain; Region: rve; cl01316
370569003360	Integrase core domain; Region: rve_3; cl15866
370569003361	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06559
370569003362	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
370569003363	dimerization interface [polypeptide binding]; other site
370569003364	active site
370569003365	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
370569003366	transmembrane helices; other site
370569003367	Helix-turn-helix domains; Region: HTH; cl00088
370569003368	putative transposase OrfB; Reviewed; Region: PHA02517
370569003369	HTH-like domain; Region: HTH_21; pfam13276
370569003370	Integrase core domain; Region: rve; cl01316
370569003371	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
370569003372	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
370569003373	RNA binding surface [nucleotide binding]; other site
370569003374	PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553
370569003375	active site
370569003376	uracil binding [chemical binding]; other site
370569003377	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
370569003378	benzoate transport; Region: 2A0115; TIGR00895
370569003379	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370569003380	putative substrate translocation pore; other site
370569003381	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
370569003382	hypothetical protein; Provisional; Region: PRK13663
370569003383	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
370569003384	CoenzymeA binding site [chemical binding]; other site
370569003385	subunit interaction site [polypeptide binding]; other site
370569003386	PHB binding site; other site
370569003387	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
370569003388	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
370569003389	TRAM domain; Region: TRAM; cl01282
370569003390	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
370569003391	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
370569003392	shikimate kinase; Reviewed; Region: aroK; PRK00131
370569003393	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
370569003394	ADP binding site [chemical binding]; other site
370569003395	magnesium binding site [ion binding]; other site
370569003396	putative shikimate binding site; other site
370569003397	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
370569003398	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
370569003399	hinge; other site
370569003400	active site
370569003401	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
370569003402	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
370569003403	active site
370569003404	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
370569003405	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
370569003406	DNA-binding site [nucleotide binding]; DNA binding site
370569003407	DRTGG domain; Region: DRTGG; cl12147
370569003408	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
370569003409	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
370569003410	active site 2 [active]
370569003411	active site 1 [active]
370569003412	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
370569003413	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
370569003414	Gram positive anchor; Region: Gram_pos_anchor; cl15427
370569003415	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
370569003416	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
370569003417	hinge; other site
370569003418	active site
370569003419	S-adenosylmethionine synthetase; Validated; Region: PRK05250
370569003420	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
370569003421	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
370569003422	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
370569003423	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
370569003424	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
370569003425	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
370569003426	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
370569003427	Substrate binding site [chemical binding]; other site
370569003428	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
370569003429	Helix-turn-helix domains; Region: HTH; cl00088
370569003430	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
370569003431	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
370569003432	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
370569003433	Protein of unknown function (DUF3272); Region: DUF3272; pfam11676
370569003434	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
370569003435	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569003436	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267
370569003437	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370569003438	Walker A motif; other site
370569003439	ATP binding site [chemical binding]; other site
370569003440	Walker B motif; other site
370569003441	GAF domain; Region: GAF; cl15785
370569003442	Protease prsW family; Region: PrsW-protease; cl15823
370569003443	Protein of unknown function (DUF1294); Region: DUF1294; cl01311
370569003444	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
370569003445	Sugar specificity; other site
370569003446	Pyrimidine base specificity; other site
370569003447	ATP-binding site [chemical binding]; other site
370569003448	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569003449	ATP binding site [chemical binding]; other site
370569003450	putative Mg++ binding site [ion binding]; other site
370569003451	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
370569003452	nucleotide binding region [chemical binding]; other site
370569003453	ATP-binding site [chemical binding]; other site
370569003454	Transposase domain (DUF772); Region: DUF772; cl15789
370569003455	Transposase domain (DUF772); Region: DUF772; cl15789
370569003456	Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947
370569003457	NodB motif; other site
370569003458	active site
370569003459	catalytic site [active]
370569003460	Zn binding site [ion binding]; other site
370569003461	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
370569003462	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
370569003463	tetrameric interface [polypeptide binding]; other site
370569003464	activator binding site; other site
370569003465	NADP binding site [chemical binding]; other site
370569003466	substrate binding site [chemical binding]; other site
370569003467	catalytic residues [active]
370569003468	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
370569003469	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
370569003470	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
370569003471	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
370569003472	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
370569003473	dimerization domain swap beta strand [polypeptide binding]; other site
370569003474	regulatory protein interface [polypeptide binding]; other site
370569003475	active site
370569003476	regulatory phosphorylation site [posttranslational modification]; other site
370569003477	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
370569003478	catalytic residues [active]
370569003479	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
370569003480	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
370569003481	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
370569003482	Class I ribonucleotide reductase; Region: RNR_I; cd01679
370569003483	active site
370569003484	dimer interface [polypeptide binding]; other site
370569003485	catalytic residues [active]
370569003486	effector binding site; other site
370569003487	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
370569003488	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
370569003489	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
370569003490	dimer interface [polypeptide binding]; other site
370569003491	putative radical transfer pathway; other site
370569003492	diiron center [ion binding]; other site
370569003493	tyrosyl radical; other site
370569003494	Transposase domain (DUF772); Region: DUF772; cl15789
370569003495	Transposase domain (DUF772); Region: DUF772; cl15789
370569003496	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
370569003497	putative ion selectivity filter; other site
370569003498	putative pore gating glutamate residue; other site
370569003499	Helix-turn-helix domains; Region: HTH; cl00088
370569003500	HTH-like domain; Region: HTH_21; pfam13276
370569003501	Integrase core domain; Region: rve; cl01316
370569003502	Integrase core domain; Region: rve_3; cl15866
370569003503	CAAX protease self-immunity; Region: Abi; cl00558
370569003504	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
370569003505	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370569003506	non-specific DNA binding site [nucleotide binding]; other site
370569003507	salt bridge; other site
370569003508	sequence-specific DNA binding site [nucleotide binding]; other site
370569003509	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
370569003510	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
370569003511	motif 1; other site
370569003512	active site
370569003513	motif 2; other site
370569003514	motif 3; other site
370569003515	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
370569003516	DHHA1 domain; Region: DHHA1; pfam02272
370569003517	foldase protein PrsA; Reviewed; Region: prsA; PRK01326
370569003518	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
370569003519	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
370569003520	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370569003521	S-adenosylmethionine binding site [chemical binding]; other site
370569003522	Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890
370569003523	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370569003524	putative substrate translocation pore; other site
370569003525	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
370569003526	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
370569003527	active site
370569003528	Zn binding site [ion binding]; other site
370569003529	Competence protein CoiA-like family; Region: CoiA; cl11541
370569003530	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
370569003531	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
370569003532	RNA binding surface [nucleotide binding]; other site
370569003533	PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553
370569003534	active site
370569003535	uracil binding [chemical binding]; other site
370569003536	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
370569003537	active site
370569003538	trimer interface [polypeptide binding]; other site
370569003539	allosteric site; other site
370569003540	active site lid [active]
370569003541	hexamer (dimer of trimers) interface [polypeptide binding]; other site
370569003542	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
370569003543	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
370569003544	Protein of unknown function (DUF3114); Region: DUF3114; pfam11311
370569003545	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
370569003546	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
370569003547	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
370569003548	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
370569003549	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
370569003550	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
370569003551	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
370569003552	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
370569003553	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
370569003554	Competence protein; Region: Competence; cl00471
370569003555	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
370569003556	SLBB domain; Region: SLBB; pfam10531
370569003557	comEA protein; Region: comE; TIGR01259
370569003558	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
370569003559	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
370569003560	putative acyl-acceptor binding pocket; other site
370569003561	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
370569003562	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569003563	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
370569003564	GIY-YIG motif/motif A; other site
370569003565	putative active site [active]
370569003566	putative metal binding site [ion binding]; other site
370569003567	K+ potassium transporter; Region: K_trans; cl15781
370569003568	K+ potassium transporter; Region: K_trans; cl15781
370569003569	helicase 45; Provisional; Region: PTZ00424
370569003570	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
370569003571	ATP binding site [chemical binding]; other site
370569003572	Mg++ binding site [ion binding]; other site
370569003573	motif III; other site
370569003574	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
370569003575	nucleotide binding region [chemical binding]; other site
370569003576	ATP-binding site [chemical binding]; other site
370569003577	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
370569003578	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
370569003579	G1 box; other site
370569003580	putative GEF interaction site [polypeptide binding]; other site
370569003581	GTP/Mg2+ binding site [chemical binding]; other site
370569003582	Switch I region; other site
370569003583	G2 box; other site
370569003584	G3 box; other site
370569003585	Switch II region; other site
370569003586	G4 box; other site
370569003587	G5 box; other site
370569003588	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
370569003589	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331
370569003590	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
370569003591	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
370569003592	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
370569003593	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
370569003594	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
370569003595	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
370569003596	ATP-grasp domain; Region: ATP-grasp_4; cl03087
370569003597	recombination protein RecR; Reviewed; Region: recR; PRK00076
370569003598	RecR protein; Region: RecR; pfam02132
370569003599	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
370569003600	putative active site [active]
370569003601	putative metal-binding site [ion binding]; other site
370569003602	tetramer interface [polypeptide binding]; other site
370569003603	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
370569003604	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
370569003605	Helix-turn-helix domains; Region: HTH; cl00088
370569003606	3H domain; Region: 3H; pfam02829
370569003607	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
370569003608	catalytic core [active]
370569003609	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
370569003610	Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167
370569003611	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
370569003612	active site
370569003613	FMN binding site [chemical binding]; other site
370569003614	substrate binding site [chemical binding]; other site
370569003615	catalytic residues [active]
370569003616	homodimer interface [polypeptide binding]; other site
370569003617	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
370569003618	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
370569003619	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
370569003620	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
370569003621	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
370569003622	Fic/DOC family N-terminal; Region: Fic_N; pfam13784
370569003623	Fic/DOC family; Region: Fic; cl00960
370569003624	NlpC/P60 family; Region: NLPC_P60; cl11438
370569003625	Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; cl07020
370569003626	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
370569003627	Bacteriophage holin; Region: Phage_holin_1; cl02344
370569003628	Protein of unknown function (DUF1617); Region: DUF1617; pfam07761
370569003629	gp58-like protein; Region: Gp58; pfam07902
370569003630	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
370569003631	Hyaluronidase protein (HylP); Region: Hyaluronidase_1; pfam07212
370569003632	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
370569003633	Phage-related protein [Function unknown]; Region: COG4722; cl15832
370569003634	Phage-related protein [Function unknown]; Region: COG5412
370569003635	Herpesvirus Glycoprotein B; Region: Glycoprotein_B; pfam00606
370569003636	Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355
370569003637	HeH/LEM domain; Region: HeH; pfam12949
370569003638	Phage capsid family; Region: Phage_capsid; pfam05065
370569003639	Domain of unknown function (DUF4355); Region: DUF4355; pfam14265
370569003640	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
370569003641	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
370569003642	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980
370569003643	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
370569003644	active site
370569003645	Protein of unknown function (DUF1492); Region: DUF1492; pfam07374
370569003646	Protein of unknown function (DUF1372); Region: DUF1372; pfam07116
370569003647	PcfJ-like protein; Region: PcfJ; pfam14284
370569003648	PcfK-like protein; Region: PcfK; pfam14058
370569003649	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
370569003650	RecT family; Region: RecT; cl04285
370569003651	RecT family; Region: RecT; cl04285
370569003652	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
370569003653	Helix-turn-helix domains; Region: HTH; cl00088
370569003654	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370569003655	non-specific DNA binding site [nucleotide binding]; other site
370569003656	salt bridge; other site
370569003657	sequence-specific DNA binding site [nucleotide binding]; other site
370569003658	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
370569003659	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370569003660	non-specific DNA binding site [nucleotide binding]; other site
370569003661	salt bridge; other site
370569003662	sequence-specific DNA binding site [nucleotide binding]; other site
370569003663	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
370569003664	Catalytic site [active]
370569003665	HIRAN domain; Region: HIRAN; cl07418
370569003666	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
370569003667	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
370569003668	Int/Topo IB signature motif; other site
370569003669	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
370569003670	IHF dimer interface [polypeptide binding]; other site
370569003671	IHF - DNA interface [nucleotide binding]; other site
370569003672	Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548
370569003673	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
370569003674	active site
370569003675	catalytic triad [active]
370569003676	oxyanion hole [active]
370569003677	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
370569003678	Gram positive anchor; Region: Gram_pos_anchor; cl15427
370569003679	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
370569003680	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
370569003681	ABC transporter signature motif; other site
370569003682	Walker B; other site
370569003683	D-loop; other site
370569003684	H-loop/switch region; other site
370569003685	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
370569003686	AAA domain; Region: AAA_23; pfam13476
370569003687	Walker A/P-loop; other site
370569003688	ATP binding site [chemical binding]; other site
370569003689	Q-loop/lid; other site
370569003690	Arginine repressor [Transcription]; Region: ArgR; COG1438
370569003691	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
370569003692	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
370569003693	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
370569003694	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
370569003695	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
370569003696	substrate binding pocket [chemical binding]; other site
370569003697	chain length determination region; other site
370569003698	substrate-Mg2+ binding site; other site
370569003699	catalytic residues [active]
370569003700	aspartate-rich region 1; other site
370569003701	active site lid residues [active]
370569003702	aspartate-rich region 2; other site
370569003703	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
370569003704	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
370569003705	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
370569003706	generic binding surface II; other site
370569003707	generic binding surface I; other site
370569003708	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179
370569003709	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
370569003710	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
370569003711	homodimer interface [polypeptide binding]; other site
370569003712	NADP binding site [chemical binding]; other site
370569003713	substrate binding site [chemical binding]; other site
370569003714	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
370569003715	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
370569003716	active site
370569003717	substrate binding site [chemical binding]; other site
370569003718	metal binding site [ion binding]; metal-binding site
370569003719	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
370569003720	DNA photolyase; Region: DNA_photolyase; pfam00875
370569003721	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
370569003722	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
370569003723	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
370569003724	Walker A/P-loop; other site
370569003725	ATP binding site [chemical binding]; other site
370569003726	Q-loop/lid; other site
370569003727	ABC transporter signature motif; other site
370569003728	Walker B; other site
370569003729	D-loop; other site
370569003730	H-loop/switch region; other site
370569003731	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
370569003732	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569003733	dimer interface [polypeptide binding]; other site
370569003734	conserved gate region; other site
370569003735	putative PBP binding loops; other site
370569003736	ABC-ATPase subunit interface; other site
370569003737	Protein of unknown function (DUF1797); Region: DUF1797; cl11550
370569003738	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
370569003739	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370569003740	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
370569003741	Walker A motif; other site
370569003742	ATP binding site [chemical binding]; other site
370569003743	Walker B motif; other site
370569003744	arginine finger; other site
370569003745	Helicase subunit of the DNA excision repair complex [DNA replication, recombination, and repair]; Region: UvrB; COG0556
370569003746	UvrB/uvrC motif; Region: UVR; pfam02151
370569003747	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370569003748	Walker A motif; other site
370569003749	ATP binding site [chemical binding]; other site
370569003750	Walker B motif; other site
370569003751	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
370569003752	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
370569003753	nudix motif; other site
370569003754	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
370569003755	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
370569003756	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
370569003757	active site
370569003758	HIGH motif; other site
370569003759	nucleotide binding site [chemical binding]; other site
370569003760	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
370569003761	active site
370569003762	KMSKS motif; other site
370569003763	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
370569003764	tRNA binding surface [nucleotide binding]; other site
370569003765	anticodon binding site; other site
370569003766	DivIVA protein; Region: DivIVA; pfam05103
370569003767	DivIVA domain; Region: DivI1A_domain; TIGR03544
370569003768	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
370569003769	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
370569003770	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
370569003771	YGGT family; Region: YGGT; cl00508
370569003772	Protein of unknown function (DUF552); Region: DUF552; cl00775
370569003773	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
370569003774	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
370569003775	catalytic residue [active]
370569003776	cell division protein FtsZ; Validated; Region: PRK09330
370569003777	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
370569003778	nucleotide binding site [chemical binding]; other site
370569003779	SulA interaction site; other site
370569003780	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
370569003781	Cell division protein FtsA; Region: FtsA; cl11496
370569003782	Cell division protein FtsA; Region: FtsA; cl11496
370569003783	Domain of unknown function (DUF3484); Region: DUF3484; pfam11983
370569003784	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
370569003785	Cell division protein FtsQ; Region: FtsQ; pfam03799
370569003786	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
370569003787	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
370569003788	active site
370569003789	homodimer interface [polypeptide binding]; other site
370569003790	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
370569003791	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
370569003792	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
370569003793	Protein of unknown function (DUF3165); Region: DUF3165; pfam11364
370569003794	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
370569003795	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
370569003796	G1 box; other site
370569003797	putative GEF interaction site [polypeptide binding]; other site
370569003798	GTP/Mg2+ binding site [chemical binding]; other site
370569003799	Switch I region; other site
370569003800	G2 box; other site
370569003801	G3 box; other site
370569003802	Switch II region; other site
370569003803	G4 box; other site
370569003804	G5 box; other site
370569003805	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
370569003806	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
370569003807	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
370569003808	active site residue [active]
370569003809	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
370569003810	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
370569003811	Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543
370569003812	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
370569003813	Ferritin-like domain; Region: Ferritin; pfam00210
370569003814	dimerization interface [polypeptide binding]; other site
370569003815	DPS ferroxidase diiron center [ion binding]; other site
370569003816	ion pore; other site
370569003817	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
370569003818	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370569003819	FeS/SAM binding site; other site
370569003820	Protein of unknown function (DUF1027); Region: DUF1027; cl09961
370569003821	Transcriptional regulators [Transcription]; Region: PurR; COG1609
370569003822	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
370569003823	DNA binding site [nucleotide binding]
370569003824	domain linker motif; other site
370569003825	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
370569003826	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
370569003827	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
370569003828	protein binding site [polypeptide binding]; other site
370569003829	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
370569003830	pantetheine-phosphate adenylyltransferase, bacterial; Region: coaD_prev_kdtB; TIGR01510
370569003831	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
370569003832	active site
370569003833	(T/H)XGH motif; other site
370569003834	Predicted archaeal methyltransferase [General function prediction only]; Region: COG2521
370569003835	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370569003836	S-adenosylmethionine binding site [chemical binding]; other site
370569003837	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
370569003838	dimer interface [polypeptide binding]; other site
370569003839	active site
370569003840	carbamate kinase; Reviewed; Region: PRK12686
370569003841	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
370569003842	putative substrate binding site [chemical binding]; other site
370569003843	nucleotide binding site [chemical binding]; other site
370569003844	nucleotide binding site [chemical binding]; other site
370569003845	homodimer interface [polypeptide binding]; other site
370569003846	hypothetical protein; Provisional; Region: PRK07205
370569003847	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
370569003848	active site
370569003849	metal binding site [ion binding]; metal-binding site
370569003850	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
370569003851	ornithine carbamoyltransferase; Validated; Region: PRK02102
370569003852	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
370569003853	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569003854	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
370569003855	Amidinotransferase; Region: Amidinotransf; cl12043
370569003856	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
370569003857	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
370569003858	ligand binding site [chemical binding]; other site
370569003859	flexible hinge region; other site
370569003860	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
370569003861	putative switch regulator; other site
370569003862	non-specific DNA interactions [nucleotide binding]; other site
370569003863	DNA binding site [nucleotide binding]
370569003864	sequence specific DNA binding site [nucleotide binding]; other site
370569003865	putative cAMP binding site [chemical binding]; other site
370569003866	Arginine repressor [Transcription]; Region: ArgR; COG1438
370569003867	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
370569003868	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
370569003869	B3/4 domain; Region: B3_4; cl11458
370569003870	Protein of unknown function (DUF419); Region: DUF419; cl15265
370569003871	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
370569003872	Cache domain; Region: Cache_1; pfam02743
370569003873	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
370569003874	Histidine kinase; Region: His_kinase; pfam06580
370569003875	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370569003876	ATP binding site [chemical binding]; other site
370569003877	Mg2+ binding site [ion binding]; other site
370569003878	G-X-G motif; other site
370569003879	Response regulator receiver domain; Region: Response_reg; pfam00072
370569003880	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370569003881	active site
370569003882	phosphorylation site [posttranslational modification]
370569003883	intermolecular recognition site; other site
370569003884	dimerization interface [polypeptide binding]; other site
370569003885	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
370569003886	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
370569003887	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
370569003888	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
370569003889	methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841
370569003890	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
370569003891	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
370569003892	catalytic residues [active]
370569003893	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
370569003894	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
370569003895	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
370569003896	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
370569003897	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689
370569003898	CRISPR-associated protein Cas8c/Csd1, subtype I-C/DVULG; Region: cas_Csd1; TIGR01863
370569003899	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004
370569003900	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651
370569003901	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
370569003902	CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641
370569003903	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569003904	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
370569003905	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
370569003906	active site
370569003907	HIGH motif; other site
370569003908	nucleotide binding site [chemical binding]; other site
370569003909	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
370569003910	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
370569003911	active site
370569003912	KMSKS motif; other site
370569003913	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
370569003914	tRNA binding surface [nucleotide binding]; other site
370569003915	anticodon binding site; other site
370569003916	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
370569003917	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569003918	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
370569003919	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
370569003920	Domain of unknown function (DUF1912); Region: DUF1912; pfam08930
370569003921	NeuB family; Region: NeuB; cl00496
370569003922	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
370569003923	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
370569003924	active site
370569003925	dimer interface [polypeptide binding]; other site
370569003926	metal binding site [ion binding]; metal-binding site
370569003927	Cupin domain; Region: Cupin_2; cl09118
370569003928	Cupin domain; Region: Cupin_2; cl09118
370569003929	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
370569003930	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370569003931	S-adenosylmethionine binding site [chemical binding]; other site
370569003932	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
370569003933	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
370569003934	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
370569003935	shikimate binding site; other site
370569003936	NAD(P) binding site [chemical binding]; other site
370569003937	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
370569003938	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
370569003939	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
370569003940	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
370569003941	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
370569003942	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370569003943	active site
370569003944	phosphorylation site [posttranslational modification]
370569003945	intermolecular recognition site; other site
370569003946	dimerization interface [polypeptide binding]; other site
370569003947	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
370569003948	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
370569003949	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
370569003950	Histidine kinase; Region: His_kinase; pfam06580
370569003951	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
370569003952	Protein of unknown function, DUF624; Region: DUF624; cl02369
370569003953	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
370569003954	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
370569003955	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
370569003956	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569003957	dimer interface [polypeptide binding]; other site
370569003958	conserved gate region; other site
370569003959	putative PBP binding loops; other site
370569003960	ABC-ATPase subunit interface; other site
370569003961	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
370569003962	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569003963	putative PBP binding loops; other site
370569003964	dimer interface [polypeptide binding]; other site
370569003965	ABC-ATPase subunit interface; other site
370569003966	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
370569003967	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
370569003968	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
370569003969	beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555
370569003970	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
370569003971	DNA-binding site [nucleotide binding]; DNA binding site
370569003972	Transcriptional regulators [Transcription]; Region: PurR; COG1609
370569003973	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
370569003974	ligand binding site [chemical binding]; other site
370569003975	dimerization interface [polypeptide binding]; other site
370569003976	Protein of unknown function (DUF1237); Region: DUF1237; cl15402
370569003977	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
370569003978	Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074
370569003979	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
370569003980	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
370569003981	TRAM domain; Region: TRAM; cl01282
370569003982	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
370569003983	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
370569003984	RecX family; Region: RecX; cl00936
370569003985	Protein of unknown function (DUF402); Region: DUF402; cl00979
370569003986	Transposase; Region: DEDD_Tnp_IS110; pfam01548
370569003987	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
370569003988	30S subunit binding site; other site
370569003989	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
370569003990	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
370569003991	active site
370569003992	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
370569003993	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
370569003994	ATP binding site [chemical binding]; other site
370569003995	putative Mg++ binding site [ion binding]; other site
370569003996	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
370569003997	nucleotide binding region [chemical binding]; other site
370569003998	ATP-binding site [chemical binding]; other site
370569003999	Uncharacterized conserved protein [Function unknown]; Region: COG1739
370569004000	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
370569004001	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
370569004002	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
370569004003	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
370569004004	dimer interface [polypeptide binding]; other site
370569004005	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370569004006	catalytic residue [active]
370569004007	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
370569004008	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
370569004009	RNA binding site [nucleotide binding]; other site
370569004010	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
370569004011	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
370569004012	active site
370569004013	motif I; other site
370569004014	motif II; other site
370569004015	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
370569004016	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
370569004017	peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791
370569004018	active site
370569004019	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
370569004020	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370569004021	active site
370569004022	phosphorylation site [posttranslational modification]
370569004023	intermolecular recognition site; other site
370569004024	dimerization interface [polypeptide binding]; other site
370569004025	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
370569004026	DNA binding residues [nucleotide binding]
370569004027	dimerization interface [polypeptide binding]; other site
370569004028	Histidine kinase; Region: HisKA_3; pfam07730
370569004029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370569004030	ATP binding site [chemical binding]; other site
370569004031	Mg2+ binding site [ion binding]; other site
370569004032	G-X-G motif; other site
370569004033	Predicted membrane protein [Function unknown]; Region: COG4758
370569004034	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
370569004035	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
370569004036	Catalytic domain of Protein Kinases; Region: PKc; cd00180
370569004037	active site
370569004038	ATP binding site [chemical binding]; other site
370569004039	substrate binding site [chemical binding]; other site
370569004040	activation loop (A-loop); other site
370569004041	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
370569004042	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
370569004043	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
370569004044	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
370569004045	active site
370569004046	16S rRNA methyltransferase B; Provisional; Region: PRK14902
370569004047	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
370569004048	putative RNA binding site [nucleotide binding]; other site
370569004049	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370569004050	S-adenosylmethionine binding site [chemical binding]; other site
370569004051	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
370569004052	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
370569004053	putative active site [active]
370569004054	substrate binding site [chemical binding]; other site
370569004055	putative cosubstrate binding site; other site
370569004056	catalytic site [active]
370569004057	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
370569004058	substrate binding site [chemical binding]; other site
370569004059	primosome assembly protein PriA; Validated; Region: PRK05580
370569004060	primosome assembly protein PriA; Validated; Region: PRK05580
370569004061	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
370569004062	ATP binding site [chemical binding]; other site
370569004063	putative Mg++ binding site [ion binding]; other site
370569004064	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
370569004065	nucleotide binding region [chemical binding]; other site
370569004066	ATP-binding site [chemical binding]; other site
370569004067	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
370569004068	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
370569004069	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
370569004070	catalytic site [active]
370569004071	G-X2-G-X-G-K; other site
370569004072	hypothetical protein; Provisional; Region: PRK00106
370569004073	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
370569004074	Transcriptional regulator [Transcription]; Region: LysR; COG0583
370569004075	Helix-turn-helix domains; Region: HTH; cl00088
370569004076	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
370569004077	dimerization interface [polypeptide binding]; other site
370569004078	putative acyltransferase; Provisional; Region: PRK05790
370569004079	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
370569004080	dimer interface [polypeptide binding]; other site
370569004081	active site
370569004082	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
370569004083	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
370569004084	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569004085	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
370569004086	NAD(P) binding site [chemical binding]; other site
370569004087	active site
370569004088	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
370569004089	Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264
370569004090	S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802
370569004091	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
370569004092	THUMP domain; Region: THUMP; cl12076
370569004093	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569004094	cell division protein GpsB; Provisional; Region: PRK14127
370569004095	DivIVA domain; Region: DivI1A_domain; TIGR03544
370569004096	Protein of unknown function (DUF1273); Region: DUF1273; cl01859
370569004097	Recombination protein U; Region: RecU; cl01314
370569004098	Transglycosylase; Region: Transgly; cl07896
370569004099	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
370569004100	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
370569004101	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
370569004102	trimer interface [polypeptide binding]; other site
370569004103	active site
370569004104	G bulge; other site
370569004105	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
370569004106	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
370569004107	homodimer interface [polypeptide binding]; other site
370569004108	NAD binding pocket [chemical binding]; other site
370569004109	ATP binding pocket [chemical binding]; other site
370569004110	Mg binding site [ion binding]; other site
370569004111	active-site loop [active]
370569004112	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
370569004113	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
370569004114	active site
370569004115	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
370569004116	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
370569004117	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569004118	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
370569004119	Protein of unknown function (DUF4059); Region: DUF4059; pfam13268
370569004120	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
370569004121	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
370569004122	Walker A/P-loop; other site
370569004123	ATP binding site [chemical binding]; other site
370569004124	Q-loop/lid; other site
370569004125	ABC transporter signature motif; other site
370569004126	Walker B; other site
370569004127	D-loop; other site
370569004128	H-loop/switch region; other site
370569004129	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569004130	dimer interface [polypeptide binding]; other site
370569004131	conserved gate region; other site
370569004132	putative PBP binding loops; other site
370569004133	ABC-ATPase subunit interface; other site
370569004134	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
370569004135	DEAD-like helicases superfamily; Region: DEXDc; smart00487
370569004136	ATP binding site [chemical binding]; other site
370569004137	Mg++ binding site [ion binding]; other site
370569004138	motif III; other site
370569004139	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
370569004140	nucleotide binding region [chemical binding]; other site
370569004141	ATP-binding site [chemical binding]; other site
370569004142	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
370569004143	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
370569004144	Mg++ binding site [ion binding]; other site
370569004145	putative catalytic motif [active]
370569004146	putative substrate binding site [chemical binding]; other site
370569004147	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
370569004148	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
370569004149	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
370569004150	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
370569004151	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
370569004152	Septum formation initiator; Region: DivIC; cl11433
370569004153	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
370569004154	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569004155	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
370569004156	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
370569004157	putative catalytic cysteine [active]
370569004158	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
370569004159	nucleotide binding site [chemical binding]; other site
370569004160	homotetrameric interface [polypeptide binding]; other site
370569004161	putative phosphate binding site [ion binding]; other site
370569004162	putative allosteric binding site; other site
370569004163	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
370569004164	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
370569004165	Walker A/P-loop; other site
370569004166	ATP binding site [chemical binding]; other site
370569004167	Q-loop/lid; other site
370569004168	ABC transporter signature motif; other site
370569004169	Walker B; other site
370569004170	D-loop; other site
370569004171	H-loop/switch region; other site
370569004172	Enterocin A Immunity; Region: EntA_Immun; pfam08951
370569004173	transketolase; Region: PLN02790
370569004174	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
370569004175	dimer interface [polypeptide binding]; other site
370569004176	TPP-binding site [chemical binding]; other site
370569004177	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
370569004178	PYR/PP interface [polypeptide binding]; other site
370569004179	dimer interface [polypeptide binding]; other site
370569004180	TPP binding site [chemical binding]; other site
370569004181	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
370569004182	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
370569004183	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
370569004184	active site
370569004185	intersubunit interactions; other site
370569004186	catalytic residue [active]
370569004187	Helix-turn-helix domains; Region: HTH; cl00088
370569004188	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
370569004189	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
370569004190	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
370569004191	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
370569004192	amphipathic channel; other site
370569004193	Asn-Pro-Ala signature motifs; other site
370569004194	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
370569004195	glycerol kinase; Provisional; Region: glpK; PRK00047
370569004196	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
370569004197	N- and C-terminal domain interface [polypeptide binding]; other site
370569004198	active site
370569004199	MgATP binding site [chemical binding]; other site
370569004200	catalytic site [active]
370569004201	metal binding site [ion binding]; metal-binding site
370569004202	glycerol binding site [chemical binding]; other site
370569004203	homotetramer interface [polypeptide binding]; other site
370569004204	homodimer interface [polypeptide binding]; other site
370569004205	FBP binding site [chemical binding]; other site
370569004206	protein IIAGlc interface [polypeptide binding]; other site
370569004207	Predicted membrane protein [Function unknown]; Region: COG3212
370569004208	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
370569004209	Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722
370569004210	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
370569004211	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
370569004212	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
370569004213	dimer interface [polypeptide binding]; other site
370569004214	motif 1; other site
370569004215	active site
370569004216	motif 2; other site
370569004217	motif 3; other site
370569004218	Phospholipid methyltransferase; Region: PEMT; cl00763
370569004219	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
370569004220	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
370569004221	active site
370569004222	catalytic tetrad [active]
370569004223	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
370569004224	active site
370569004225	dimer interface [polypeptide binding]; other site
370569004226	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
370569004227	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
370569004228	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
370569004229	PhoU domain; Region: PhoU; pfam01895
370569004230	PhoU domain; Region: PhoU; pfam01895
370569004231	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
370569004232	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
370569004233	Helix-turn-helix domains; Region: HTH; cl00088
370569004234	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
370569004235	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
370569004236	active site
370569004237	motif I; other site
370569004238	motif II; other site
370569004239	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
370569004240	Predicted membrane protein [Function unknown]; Region: COG2860
370569004241	UPF0126 domain; Region: UPF0126; pfam03458
370569004242	UPF0126 domain; Region: UPF0126; pfam03458
370569004243	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
370569004244	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
370569004245	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
370569004246	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
370569004247	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
370569004248	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
370569004249	active site
370569004250	P-loop; other site
370569004251	phosphorylation site [posttranslational modification]
370569004252	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
370569004253	active site
370569004254	phosphorylation site [posttranslational modification]
370569004255	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
370569004256	Helix-turn-helix domains; Region: HTH; cl00088
370569004257	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
370569004258	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
370569004259	metal-binding site [ion binding]
370569004260	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
370569004261	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
370569004262	metal-binding site [ion binding]
370569004263	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
370569004264	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
370569004265	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
370569004266	Helix-turn-helix domains; Region: HTH; cl00088
370569004267	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
370569004268	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
370569004269	Ribosome-binding factor A; Region: RBFA; cl00542
370569004270	translation initiation factor IF-2; Validated; Region: infB; PRK05306
370569004271	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
370569004272	translation initiation factor IF-2; Region: IF-2; TIGR00487
370569004273	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
370569004274	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
370569004275	G1 box; other site
370569004276	putative GEF interaction site [polypeptide binding]; other site
370569004277	GTP/Mg2+ binding site [chemical binding]; other site
370569004278	Switch I region; other site
370569004279	G2 box; other site
370569004280	G3 box; other site
370569004281	Switch II region; other site
370569004282	G4 box; other site
370569004283	G5 box; other site
370569004284	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
370569004285	Translation-initiation factor 2; Region: IF-2; pfam11987
370569004286	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
370569004287	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
370569004288	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
370569004289	putative RNA binding cleft [nucleotide binding]; other site
370569004290	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
370569004291	NusA N-terminal domain; Region: NusA_N; pfam08529
370569004292	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
370569004293	RNA binding site [nucleotide binding]; other site
370569004294	homodimer interface [polypeptide binding]; other site
370569004295	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
370569004296	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
370569004297	G-X-X-G motif; other site
370569004298	ribosome maturation protein RimP; Reviewed; Region: PRK00092
370569004299	YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold.  The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734
370569004300	Sm1 motif; other site
370569004301	predicted subunit interaction site [polypeptide binding]; other site
370569004302	RNA binding pocket [nucleotide binding]; other site
370569004303	Sm2 motif; other site
370569004304	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370569004305	S-adenosylmethionine binding site [chemical binding]; other site
370569004306	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
370569004307	Phosphotransferase enzyme family; Region: APH; pfam01636
370569004308	Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542
370569004309	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
370569004310	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
370569004311	Walker A/P-loop; other site
370569004312	ATP binding site [chemical binding]; other site
370569004313	Q-loop/lid; other site
370569004314	ABC transporter signature motif; other site
370569004315	Walker B; other site
370569004316	D-loop; other site
370569004317	H-loop/switch region; other site
370569004318	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
370569004319	HIT family signature motif; other site
370569004320	catalytic residue [active]
370569004321	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
370569004322	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
370569004323	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
370569004324	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
370569004325	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
370569004326	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
370569004327	active site
370569004328	motif I; other site
370569004329	motif II; other site
370569004330	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
370569004331	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
370569004332	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
370569004333	active pocket/dimerization site; other site
370569004334	active site
370569004335	phosphorylation site [posttranslational modification]
370569004336	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
370569004337	active site
370569004338	phosphorylation site [posttranslational modification]
370569004339	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
370569004340	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
370569004341	Domain of unknown function (DUF956); Region: DUF956; cl01917
370569004342	seryl-tRNA synthetase; Provisional; Region: PRK05431
370569004343	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
370569004344	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
370569004345	dimer interface [polypeptide binding]; other site
370569004346	active site
370569004347	motif 1; other site
370569004348	motif 2; other site
370569004349	motif 3; other site
370569004350	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
370569004351	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
370569004352	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
370569004353	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
370569004354	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
370569004355	ATP-grasp domain; Region: ATP-grasp_4; cl03087
370569004356	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
370569004357	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
370569004358	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
370569004359	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
370569004360	carboxyltransferase (CT) interaction site; other site
370569004361	biotinylation site [posttranslational modification]; other site
370569004362	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
370569004363	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
370569004364	dimer interface [polypeptide binding]; other site
370569004365	active site
370569004366	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
370569004367	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
370569004368	NAD(P) binding site [chemical binding]; other site
370569004369	homotetramer interface [polypeptide binding]; other site
370569004370	homodimer interface [polypeptide binding]; other site
370569004371	active site
370569004372	Acyl transferase domain; Region: Acyl_transf_1; cl08282
370569004373	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
370569004374	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
370569004375	FMN binding site [chemical binding]; other site
370569004376	substrate binding site [chemical binding]; other site
370569004377	putative catalytic residue [active]
370569004378	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
370569004379	Phosphopantetheine attachment site; Region: PP-binding; cl09936
370569004380	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
370569004381	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
370569004382	dimer interface [polypeptide binding]; other site
370569004383	active site
370569004384	CoA binding pocket [chemical binding]; other site
370569004385	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
370569004386	Helix-turn-helix domains; Region: HTH; cl00088
370569004387	enoyl-CoA hydratase; Provisional; Region: PRK07260
370569004388	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
370569004389	substrate binding site [chemical binding]; other site
370569004390	oxyanion hole (OAH) forming residues; other site
370569004391	trimer interface [polypeptide binding]; other site
370569004392	chaperone protein DnaJ; Provisional; Region: PRK14276
370569004393	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
370569004394	HSP70 interaction site [polypeptide binding]; other site
370569004395	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
370569004396	substrate binding site [polypeptide binding]; other site
370569004397	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
370569004398	Zn binding sites [ion binding]; other site
370569004399	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
370569004400	dimer interface [polypeptide binding]; other site
370569004401	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
370569004402	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
370569004403	dimer interface [polypeptide binding]; other site
370569004404	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
370569004405	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
370569004406	HrcA protein C terminal domain; Region: HrcA; pfam01628
370569004407	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
370569004408	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
370569004409	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
370569004410	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
370569004411	catalytic core [active]
370569004412	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
370569004413	Transglycosylase associated protein; Region: Transgly_assoc; cl00978
370569004414	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
370569004415	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
370569004416	GatB domain; Region: GatB_Yqey; cl11497
370569004417	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
370569004418	Amidase; Region: Amidase; cl11426
370569004419	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
370569004420	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
370569004421	pyruvate phosphate dikinase; Provisional; Region: PRK09279
370569004422	Isochorismatase family; Region: Isochorismatase; pfam00857
370569004423	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
370569004424	catalytic triad [active]
370569004425	conserved cis-peptide bond; other site
370569004426	transcriptional repressor CodY; Validated; Region: PRK04158
370569004427	CodY GAF-like domain; Region: CodY; pfam06018
370569004428	Helix-turn-helix domains; Region: HTH; cl00088
370569004429	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
370569004430	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
370569004431	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370569004432	homodimer interface [polypeptide binding]; other site
370569004433	catalytic residue [active]
370569004434	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
370569004435	Ligand Binding Site [chemical binding]; other site
370569004436	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
370569004437	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
370569004438	active site
370569004439	motif I; other site
370569004440	motif II; other site
370569004441	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
370569004442	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
370569004443	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
370569004444	active site
370569004445	homotetramer interface [polypeptide binding]; other site
370569004446	homodimer interface [polypeptide binding]; other site
370569004447	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
370569004448	The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance.  Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis.  The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268
370569004449	Walker A/P-loop; other site
370569004450	ATP binding site [chemical binding]; other site
370569004451	Q-loop/lid; other site
370569004452	ABC transporter signature motif; other site
370569004453	Walker B; other site
370569004454	D-loop; other site
370569004455	H-loop/switch region; other site
370569004456	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
370569004457	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
370569004458	generic binding surface II; other site
370569004459	ssDNA binding site; other site
370569004460	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
370569004461	ATP binding site [chemical binding]; other site
370569004462	putative Mg++ binding site [ion binding]; other site
370569004463	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
370569004464	nucleotide binding region [chemical binding]; other site
370569004465	ATP-binding site [chemical binding]; other site
370569004466	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
370569004467	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
370569004468	Walker A/P-loop; other site
370569004469	ATP binding site [chemical binding]; other site
370569004470	Q-loop/lid; other site
370569004471	ABC transporter signature motif; other site
370569004472	Walker B; other site
370569004473	D-loop; other site
370569004474	H-loop/switch region; other site
370569004475	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569004476	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
370569004477	Walker A/P-loop; other site
370569004478	ATP binding site [chemical binding]; other site
370569004479	Q-loop/lid; other site
370569004480	ABC transporter signature motif; other site
370569004481	Walker B; other site
370569004482	D-loop; other site
370569004483	H-loop/switch region; other site
370569004484	Cobalt transport protein; Region: CbiQ; cl00463
370569004485	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
370569004486	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
370569004487	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
370569004488	The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export.  They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins.  The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228
370569004489	Walker A/P-loop; other site
370569004490	ATP binding site [chemical binding]; other site
370569004491	Q-loop/lid; other site
370569004492	ABC transporter signature motif; other site
370569004493	Walker B; other site
370569004494	D-loop; other site
370569004495	H-loop/switch region; other site
370569004496	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
370569004497	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
370569004498	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569004499	Walker A/P-loop; other site
370569004500	ATP binding site [chemical binding]; other site
370569004501	Q-loop/lid; other site
370569004502	ABC transporter signature motif; other site
370569004503	Walker B; other site
370569004504	D-loop; other site
370569004505	H-loop/switch region; other site
370569004506	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
370569004507	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
370569004508	Walker A/P-loop; other site
370569004509	ATP binding site [chemical binding]; other site
370569004510	Q-loop/lid; other site
370569004511	ABC transporter signature motif; other site
370569004512	Walker B; other site
370569004513	D-loop; other site
370569004514	H-loop/switch region; other site
370569004515	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
370569004516	ABC-ATPase subunit  interface; other site
370569004517	dimer interface [polypeptide binding]; other site
370569004518	putative PBP binding regions; other site
370569004519	heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659
370569004520	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
370569004521	putative ligand binding residues [chemical binding]; other site
370569004522	Cell surface heme-binding protein Shp; Region: HemeBinding_Shp; pfam11545
370569004523	Protein of unknown function (DUF1533); Region: DUF1533; pfam07550
370569004524	Protein of unknown function (DUF1533); Region: DUF1533; pfam07550
370569004525	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
370569004526	heme-binding site [chemical binding]; other site
370569004527	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
370569004528	Leucine-rich repeats; other site
370569004529	Leucine rich repeat; Region: LRR_8; pfam13855
370569004530	Substrate binding site [chemical binding]; other site
370569004531	Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886
370569004532	NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920
370569004533	heme-binding site [chemical binding]; other site
370569004534	Surface antigen [General function prediction only]; Region: COG3942
370569004535	NlpC/P60 family; Region: NLPC_P60; cl11438
370569004536	alanine racemase; Reviewed; Region: alr; PRK00053
370569004537	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
370569004538	active site
370569004539	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
370569004540	dimer interface [polypeptide binding]; other site
370569004541	substrate binding site [chemical binding]; other site
370569004542	catalytic residues [active]
370569004543	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
370569004544	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
370569004545	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
370569004546	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
370569004547	nucleotide binding region [chemical binding]; other site
370569004548	ATP-binding site [chemical binding]; other site
370569004549	SEC-C motif; Region: SEC-C; pfam02810
370569004550	Transposase [DNA replication, recombination, and repair]; Region: COG5433
370569004551	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
370569004552	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
370569004553	Phosphomannose isomerase type I; Region: PMI_typeI; cl15429
370569004554	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
370569004555	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
370569004556	Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542
370569004557	active site
370569004558	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
370569004559	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
370569004560	active site turn [active]
370569004561	phosphorylation site [posttranslational modification]
370569004562	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
370569004563	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
370569004564	HPr interaction site; other site
370569004565	glycerol kinase (GK) interaction site [polypeptide binding]; other site
370569004566	active site
370569004567	phosphorylation site [posttranslational modification]
370569004568	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
370569004569	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
370569004570	substrate binding [chemical binding]; other site
370569004571	active site
370569004572	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
370569004573	lac repressor; Reviewed; Region: lacI; PRK09526
370569004574	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
370569004575	DNA binding site [nucleotide binding]
370569004576	domain linker motif; other site
370569004577	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
370569004578	dimerization interface [polypeptide binding]; other site
370569004579	ligand binding site [chemical binding]; other site
370569004580	sodium binding site [ion binding]; other site
370569004581	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
370569004582	putative RNA binding site [nucleotide binding]; other site
370569004583	Asp23 family; Region: Asp23; cl00574
370569004584	elongation factor P; Validated; Region: PRK00529
370569004585	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
370569004586	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
370569004587	RNA binding site [nucleotide binding]; other site
370569004588	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
370569004589	RNA binding site [nucleotide binding]; other site
370569004590	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
370569004591	catalytic motif [active]
370569004592	Zn binding site [ion binding]; other site
370569004593	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
370569004594	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
370569004595	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
370569004596	active site
370569004597	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
370569004598	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
370569004599	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
370569004600	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
370569004601	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
370569004602	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
370569004603	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
370569004604	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
370569004605	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
370569004606	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
370569004607	dimer interface [polypeptide binding]; other site
370569004608	ssDNA binding site [nucleotide binding]; other site
370569004609	tetramer (dimer of dimers) interface [polypeptide binding]; other site
370569004610	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
370569004611	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
370569004612	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
370569004613	minor groove reading motif; other site
370569004614	helix-hairpin-helix signature motif; other site
370569004615	substrate binding pocket [chemical binding]; other site
370569004616	active site
370569004617	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
370569004618	DNA binding and oxoG recognition site [nucleotide binding]
370569004619	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370569004620	non-specific DNA binding site [nucleotide binding]; other site
370569004621	salt bridge; other site
370569004622	sequence-specific DNA binding site [nucleotide binding]; other site
370569004623	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
370569004624	catalytic residues [active]
370569004625	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
370569004626	active site
370569004627	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
370569004628	MutS2 homologs in bacteria and eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280
370569004629	Walker A/P-loop; other site
370569004630	ATP binding site [chemical binding]; other site
370569004631	Q-loop/lid; other site
370569004632	ABC transporter signature motif; other site
370569004633	Walker B; other site
370569004634	D-loop; other site
370569004635	H-loop/switch region; other site
370569004636	Smr domain; Region: Smr; cl02619
370569004637	Colicin V production protein; Region: Colicin_V; cl00567
370569004638	ribonuclease HIII; Provisional; Region: PRK00996
370569004639	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
370569004640	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
370569004641	RNA/DNA hybrid binding site [nucleotide binding]; other site
370569004642	active site
370569004643	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
370569004644	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
370569004645	Catalytic site [active]
370569004646	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
370569004647	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
370569004648	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
370569004649	DNA binding site [nucleotide binding]
370569004650	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569004651	Family description; Region: UvrD_C_2; cl15862
370569004652	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
370569004653	active site
370569004654	DNA polymerase IV; Validated; Region: PRK02406
370569004655	DNA binding site [nucleotide binding]
370569004656	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
370569004657	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
370569004658	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
370569004659	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
370569004660	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
370569004661	amphipathic channel; other site
370569004662	Asn-Pro-Ala signature motifs; other site
370569004663	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370569004664	putative substrate translocation pore; other site
370569004665	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
370569004666	Helix-turn-helix domains; Region: HTH; cl00088
370569004667	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
370569004668	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696
370569004669	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
370569004670	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370569004671	non-specific DNA binding site [nucleotide binding]; other site
370569004672	salt bridge; other site
370569004673	sequence-specific DNA binding site [nucleotide binding]; other site
370569004674	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370569004675	non-specific DNA binding site [nucleotide binding]; other site
370569004676	salt bridge; other site
370569004677	sequence-specific DNA binding site [nucleotide binding]; other site
370569004678	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
370569004679	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
370569004680	DNA binding residues [nucleotide binding]
370569004681	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
370569004682	active site
370569004683	catalytic site [active]
370569004684	substrate binding site [chemical binding]; other site
370569004685	Helix-turn-helix domains; Region: HTH; cl00088
370569004686	HI0933-like protein; Region: HI0933_like; pfam03486
370569004687	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569004688	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
370569004689	intersubunit interface [polypeptide binding]; other site
370569004690	active site
370569004691	catalytic residue [active]
370569004692	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
370569004693	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
370569004694	Nucleoside recognition; Region: Gate; cl00486
370569004695	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
370569004696	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
370569004697	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
370569004698	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
370569004699	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
370569004700	DNA-binding site [nucleotide binding]; DNA binding site
370569004701	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
370569004702	UGMP family protein; Validated; Region: PRK09604
370569004703	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
370569004704	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
370569004705	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
370569004706	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
370569004707	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
370569004708	Coenzyme A binding pocket [chemical binding]; other site
370569004709	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
370569004710	Glycoprotease family; Region: Peptidase_M22; pfam00814
370569004711	Protein of unknown function (DUF1447); Region: DUF1447; cl11492
370569004712	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
370569004713	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
370569004714	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
370569004715	glutamine synthetase, type I; Region: GlnA; TIGR00653
370569004716	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
370569004717	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
370569004718	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
370569004719	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
370569004720	DNA binding residues [nucleotide binding]
370569004721	putative dimer interface [polypeptide binding]; other site
370569004722	Fusaric acid resistance protein-like; Region: FUSC_2; cl15844
370569004723	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
370569004724	Phosphoglycerate kinase; Region: PGK; pfam00162
370569004725	substrate binding site [chemical binding]; other site
370569004726	hinge regions; other site
370569004727	ADP binding site [chemical binding]; other site
370569004728	catalytic site [active]
370569004729	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
370569004730	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
370569004731	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
370569004732	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
370569004733	DAK2 domain; Region: Dak2; cl03685
370569004734	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
370569004735	Asp23 family; Region: Asp23; cl00574
370569004736	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
370569004737	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
370569004738	hypothetical protein; Provisional; Region: PRK08185
370569004739	intersubunit interface [polypeptide binding]; other site
370569004740	active site
370569004741	zinc binding site [ion binding]; other site
370569004742	Na+ binding site [ion binding]; other site
370569004743	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
370569004744	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
370569004745	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
370569004746	CTP synthetase; Validated; Region: pyrG; PRK05380
370569004747	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
370569004748	Catalytic site [active]
370569004749	active site
370569004750	UTP binding site [chemical binding]; other site
370569004751	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
370569004752	active site
370569004753	putative oxyanion hole; other site
370569004754	catalytic triad [active]
370569004755	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319
370569004756	trigger factor; Provisional; Region: tig; PRK01490
370569004757	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
370569004758	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
370569004759	Mechanosensitive ion channel; Region: MS_channel; pfam00924
370569004760	Protein of unknown function (DUF436); Region: DUF436; cl01860
370569004761	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
370569004762	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
370569004763	substrate binding site [chemical binding]; other site
370569004764	dimer interface [polypeptide binding]; other site
370569004765	ATP binding site [chemical binding]; other site
370569004766	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
370569004767	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570
370569004768	dimerization interface 3.5A [polypeptide binding]; other site
370569004769	active site
370569004770	Glycerate kinase family; Region: Gly_kinase; cl00841
370569004771	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
370569004772	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
370569004773	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
370569004774	ATP binding site [chemical binding]; other site
370569004775	putative Mg++ binding site [ion binding]; other site
370569004776	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
370569004777	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
370569004778	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
370569004779	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
370569004780	HsdM N-terminal domain; Region: HsdM_N; pfam12161
370569004781	Helix-turn-helix domains; Region: HTH; cl00088
370569004782	hypothetical protein; Validated; Region: PRK08116
370569004783	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370569004784	Walker A motif; other site
370569004785	ATP binding site [chemical binding]; other site
370569004786	Walker B motif; other site
370569004787	arginine finger; other site
370569004788	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
370569004789	BRO family, N-terminal domain; Region: Bro-N; cl10591
370569004790	Phage antirepressor protein KilAC domain; Region: ANT; cl01462
370569004791	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
370569004792	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569004793	Walker A motif; other site
370569004794	ATP binding site [chemical binding]; other site
370569004795	Walker B motif; other site
370569004796	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
370569004797	generic binding surface II; other site
370569004798	generic binding surface I; other site
370569004799	Maff2 family; Region: Maff2; pfam12750
370569004800	PrgI family protein; Region: PrgI; pfam12666
370569004801	Type IV secretory pathway, VirB4 components [Intracellular trafficking and secretion]; Region: VirB4; COG3451
370569004802	Domain of unknown function DUF87; Region: DUF87; pfam01935
370569004803	AAA-like domain; Region: AAA_10; pfam12846
370569004804	NlpC/P60 family; Region: NLPC_P60; cl11438
370569004805	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
370569004806	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
370569004807	TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325
370569004808	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
370569004809	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
370569004810	DNA topoisomerase III; Provisional; Region: PRK07726
370569004811	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
370569004812	active site
370569004813	putative interdomain interaction site [polypeptide binding]; other site
370569004814	putative metal-binding site [ion binding]; other site
370569004815	putative nucleotide binding site [chemical binding]; other site
370569004816	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
370569004817	domain I; other site
370569004818	DNA binding groove [nucleotide binding]
370569004819	phosphate binding site [ion binding]; other site
370569004820	domain II; other site
370569004821	domain III; other site
370569004822	nucleotide binding site [chemical binding]; other site
370569004823	catalytic site [active]
370569004824	domain IV; other site
370569004825	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
370569004826	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
370569004827	cofactor binding site; other site
370569004828	DNA binding site [nucleotide binding]
370569004829	substrate interaction site [chemical binding]; other site
370569004830	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569004831	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569004832	DEAD-like helicases superfamily; Region: DEXDc; smart00487
370569004833	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569004834	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569004835	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
370569004836	Helix-turn-helix domains; Region: HTH; cl00088
370569004837	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
370569004838	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
370569004839	Walker A/P-loop; other site
370569004840	ATP binding site [chemical binding]; other site
370569004841	Q-loop/lid; other site
370569004842	ABC transporter signature motif; other site
370569004843	Walker B; other site
370569004844	D-loop; other site
370569004845	H-loop/switch region; other site
370569004846	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
370569004847	ABC-2 type transporter; Region: ABC2_membrane; cl11417
370569004848	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370569004849	S-adenosylmethionine binding site [chemical binding]; other site
370569004850	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
370569004851	substrate binding site [chemical binding]; other site
370569004852	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
370569004853	active site
370569004854	catalytic motif [active]
370569004855	Zn binding site [ion binding]; other site
370569004856	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
370569004857	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
370569004858	Myosin heavy chain [Cytoskeleton]; Region: COG5022
370569004859	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
370569004860	putative active site [active]
370569004861	putative NTP binding site [chemical binding]; other site
370569004862	putative nucleic acid binding site [nucleotide binding]; other site
370569004863	Type II intron maturase; Region: Intron_maturas2; pfam01348
370569004864	Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584
370569004865	Virulence protein [General function prediction only]; Region: COG3943
370569004866	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
370569004867	Domain of unknown function (DUF955); Region: DUF955; cl01076
370569004868	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
370569004869	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370569004870	non-specific DNA binding site [nucleotide binding]; other site
370569004871	salt bridge; other site
370569004872	sequence-specific DNA binding site [nucleotide binding]; other site
370569004873	DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191
370569004874	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
370569004875	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
370569004876	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
370569004877	catalytic residues [active]
370569004878	catalytic nucleophile [active]
370569004879	Recombinase; Region: Recombinase; pfam07508
370569004880	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
370569004881	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
370569004882	catalytic residues [active]
370569004883	catalytic nucleophile [active]
370569004884	Recombinase; Region: Recombinase; pfam07508
370569004885	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
370569004886	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
370569004887	catalytic residues [active]
370569004888	catalytic nucleophile [active]
370569004889	Recombinase; Region: Recombinase; pfam07508
370569004890	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
370569004891	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
370569004892	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569004893	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
370569004894	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370569004895	active site
370569004896	phosphorylation site [posttranslational modification]
370569004897	intermolecular recognition site; other site
370569004898	dimerization interface [polypeptide binding]; other site
370569004899	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
370569004900	DNA binding residues [nucleotide binding]
370569004901	dimerization interface [polypeptide binding]; other site
370569004902	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
370569004903	FtsX-like permease family; Region: FtsX; cl15850
370569004904	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
370569004905	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
370569004906	Walker A/P-loop; other site
370569004907	ATP binding site [chemical binding]; other site
370569004908	Q-loop/lid; other site
370569004909	ABC transporter signature motif; other site
370569004910	Walker B; other site
370569004911	D-loop; other site
370569004912	H-loop/switch region; other site
370569004913	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39F; cd02425
370569004914	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
370569004915	putative active site [active]
370569004916	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
370569004917	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569004918	Walker A/P-loop; other site
370569004919	ATP binding site [chemical binding]; other site
370569004920	Q-loop/lid; other site
370569004921	ABC transporter signature motif; other site
370569004922	Walker B; other site
370569004923	D-loop; other site
370569004924	H-loop/switch region; other site
370569004925	Lantibiotic modifying enzyme [Defense mechanisms]; Region: LcnDR2; COG4403
370569004926	LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792
370569004927	active site
370569004928	zinc binding site [ion binding]; other site
370569004929	Type-A lantibiotic; Region: L_biotic_typeA; pfam04604
370569004930	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
370569004931	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
370569004932	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
370569004933	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
370569004934	active site
370569004935	P-loop; other site
370569004936	phosphorylation site [posttranslational modification]
370569004937	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
370569004938	methionine cluster; other site
370569004939	active site
370569004940	phosphorylation site [posttranslational modification]
370569004941	metal binding site [ion binding]; metal-binding site
370569004942	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
370569004943	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
370569004944	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
370569004945	putative substrate binding site [chemical binding]; other site
370569004946	putative ATP binding site [chemical binding]; other site
370569004947	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
370569004948	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
370569004949	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
370569004950	Helix-turn-helix domains; Region: HTH; cl00088
370569004951	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
370569004952	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
370569004953	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
370569004954	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
370569004955	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
370569004956	23S rRNA interface [nucleotide binding]; other site
370569004957	L3 interface [polypeptide binding]; other site
370569004958	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370569004959	non-specific DNA binding site [nucleotide binding]; other site
370569004960	salt bridge; other site
370569004961	sequence-specific DNA binding site [nucleotide binding]; other site
370569004962	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
370569004963	YacP-like NYN domain; Region: NYN_YacP; cl01491
370569004964	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
370569004965	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
370569004966	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
370569004967	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
370569004968	active site
370569004969	metal binding site [ion binding]; metal-binding site
370569004970	dimerization interface [polypeptide binding]; other site
370569004971	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
370569004972	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
370569004973	active site
370569004974	HIGH motif; other site
370569004975	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
370569004976	KMSKS motif; other site
370569004977	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
370569004978	tRNA binding surface [nucleotide binding]; other site
370569004979	anticodon binding site; other site
370569004980	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
370569004981	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
370569004982	trimer interface [polypeptide binding]; other site
370569004983	active site
370569004984	substrate binding site [chemical binding]; other site
370569004985	CoA binding site [chemical binding]; other site
370569004986	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
370569004987	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
370569004988	RNase E interface [polypeptide binding]; other site
370569004989	trimer interface [polypeptide binding]; other site
370569004990	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
370569004991	RNase E interface [polypeptide binding]; other site
370569004992	trimer interface [polypeptide binding]; other site
370569004993	active site
370569004994	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
370569004995	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
370569004996	RNA binding site [nucleotide binding]; other site
370569004997	domain interface; other site
370569004998	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
370569004999	active site
370569005000	intersubunit interactions; other site
370569005001	catalytic residue [active]
370569005002	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
370569005003	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
370569005004	active site
370569005005	P-loop; other site
370569005006	phosphorylation site [posttranslational modification]
370569005007	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
370569005008	PRD domain; Region: PRD; cl15445
370569005009	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
370569005010	active site
370569005011	P-loop; other site
370569005012	phosphorylation site [posttranslational modification]
370569005013	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
370569005014	active site
370569005015	phosphorylation site [posttranslational modification]
370569005016	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
370569005017	16S/18S rRNA binding site [nucleotide binding]; other site
370569005018	S13e-L30e interaction site [polypeptide binding]; other site
370569005019	25S rRNA binding site [nucleotide binding]; other site
370569005020	Helix-turn-helix domains; Region: HTH; cl00088
370569005021	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
370569005022	active site
370569005023	catalytic residues [active]
370569005024	metal binding site [ion binding]; metal-binding site
370569005025	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
370569005026	Helix-turn-helix domains; Region: HTH; cl00088
370569005027	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
370569005028	DNA polymerase III PolC; Validated; Region: polC; PRK00448
370569005029	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
370569005030	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
370569005031	generic binding surface II; other site
370569005032	generic binding surface I; other site
370569005033	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
370569005034	active site
370569005035	catalytic site [active]
370569005036	substrate binding site [chemical binding]; other site
370569005037	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
370569005038	prolyl-tRNA synthetase; Provisional; Region: PRK09194
370569005039	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779
370569005040	dimer interface [polypeptide binding]; other site
370569005041	motif 1; other site
370569005042	active site
370569005043	motif 2; other site
370569005044	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
370569005045	putative deacylase active site [active]
370569005046	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
370569005047	active site
370569005048	motif 3; other site
370569005049	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
370569005050	anticodon binding site; other site
370569005051	RIP metalloprotease RseP; Region: TIGR00054
370569005052	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
370569005053	active site
370569005054	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
370569005055	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
370569005056	putative substrate binding region [chemical binding]; other site
370569005057	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
370569005058	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
370569005059	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
370569005060	catalytic residue [active]
370569005061	putative FPP diphosphate  binding site; other site
370569005062	putative FPP binding hydrophobic cleft; other site
370569005063	dimer interface [polypeptide binding]; other site
370569005064	putative IPP diphosphate binding site; other site
370569005065	Preprotein translocase subunit; Region: YajC; cl00806
370569005066	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
370569005067	catalytic residues [active]
370569005068	pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102
370569005069	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
370569005070	carbohydrate binding site [chemical binding]; other site
370569005071	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
370569005072	carbohydrate binding site [chemical binding]; other site
370569005073	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
370569005074	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
370569005075	Ca binding site [ion binding]; other site
370569005076	active site
370569005077	catalytic site [active]
370569005078	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
370569005079	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
370569005080	Ca binding site [ion binding]; other site
370569005081	active site
370569005082	catalytic site [active]
370569005083	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
370569005084	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
370569005085	Walker A/P-loop; other site
370569005086	ATP binding site [chemical binding]; other site
370569005087	Q-loop/lid; other site
370569005088	ABC transporter signature motif; other site
370569005089	Walker B; other site
370569005090	D-loop; other site
370569005091	H-loop/switch region; other site
370569005092	TOBE domain; Region: TOBE_2; cl01440
370569005093	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
370569005094	Helix-turn-helix domains; Region: HTH; cl00088
370569005095	Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821
370569005096	Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821
370569005097	Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821
370569005098	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cl00253
370569005099	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
370569005100	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
370569005101	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
370569005102	synthetase active site [active]
370569005103	NTP binding site [chemical binding]; other site
370569005104	metal binding site [ion binding]; metal-binding site
370569005105	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
370569005106	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
370569005107	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
370569005108	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
370569005109	putative catalytic site [active]
370569005110	putative metal binding site [ion binding]; other site
370569005111	putative phosphate binding site [ion binding]; other site
370569005112	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
370569005113	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
370569005114	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
370569005115	active site turn [active]
370569005116	phosphorylation site [posttranslational modification]
370569005117	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
370569005118	HPr interaction site; other site
370569005119	glycerol kinase (GK) interaction site [polypeptide binding]; other site
370569005120	active site
370569005121	phosphorylation site [posttranslational modification]
370569005122	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611
370569005123	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
370569005124	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
370569005125	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370569005126	S-adenosylmethionine binding site [chemical binding]; other site
370569005127	Protein of unknown function (DUF3013); Region: DUF3013; pfam11217
370569005128	amidase; Provisional; Region: PRK06529
370569005129	Amidase; Region: Amidase; cl11426
370569005130	aminodeoxychorismate synthase; Provisional; Region: PRK07508
370569005131	chorismate binding enzyme; Region: Chorismate_bind; cl10555
370569005132	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
370569005133	substrate-cofactor binding pocket; other site
370569005134	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370569005135	catalytic residue [active]
370569005136	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
370569005137	Glutamine amidotransferase class-I; Region: GATase; pfam00117
370569005138	glutamine binding [chemical binding]; other site
370569005139	catalytic triad [active]
370569005140	recombination factor protein RarA; Reviewed; Region: PRK13342
370569005141	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370569005142	Walker A motif; other site
370569005143	ATP binding site [chemical binding]; other site
370569005144	Walker B motif; other site
370569005145	arginine finger; other site
370569005146	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
370569005147	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
370569005148	Coenzyme A binding pocket [chemical binding]; other site
370569005149	topology modulation protein; Provisional; Region: PRK07261
370569005150	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569005151	Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123
370569005152	Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876
370569005153	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
370569005154	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
370569005155	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
370569005156	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569005157	dimer interface [polypeptide binding]; other site
370569005158	conserved gate region; other site
370569005159	putative PBP binding loops; other site
370569005160	ABC-ATPase subunit interface; other site
370569005161	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370569005162	dimer interface [polypeptide binding]; other site
370569005163	conserved gate region; other site
370569005164	putative PBP binding loops; other site
370569005165	ABC-ATPase subunit interface; other site
370569005166	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
370569005167	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
370569005168	Walker A/P-loop; other site
370569005169	ATP binding site [chemical binding]; other site
370569005170	Q-loop/lid; other site
370569005171	ABC transporter signature motif; other site
370569005172	Walker B; other site
370569005173	D-loop; other site
370569005174	H-loop/switch region; other site
370569005175	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
370569005176	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
370569005177	Walker A/P-loop; other site
370569005178	ATP binding site [chemical binding]; other site
370569005179	Q-loop/lid; other site
370569005180	ABC transporter signature motif; other site
370569005181	Walker B; other site
370569005182	D-loop; other site
370569005183	H-loop/switch region; other site
370569005184	CsbD-like; Region: CsbD; cl15799
370569005185	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
370569005186	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
370569005187	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
370569005188	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
370569005189	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
370569005190	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
370569005191	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
370569005192	metal binding site [ion binding]; metal-binding site
370569005193	YSIRK type signal peptide; Region: YSIRK_signal; cl04650
370569005194	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
370569005195	putative active site [active]
370569005196	catalytic triad [active]
370569005197	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
370569005198	PA/protease domain interface [polypeptide binding]; other site
370569005199	putative integrin binding motif; other site
370569005200	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
370569005201	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
370569005202	FlgD Ig-like domain; Region: FlgD_ig; cl15790
370569005203	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
370569005204	Gram positive anchor; Region: Gram_pos_anchor; cl15427
370569005205	YSIRK type signal peptide; Region: YSIRK_signal; cl04650
370569005206	UV radiation resistance protein and autophagy-related subunit 14; Region: Atg14; pfam10186
370569005207	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
370569005208	Gram positive anchor; Region: Gram_pos_anchor; cl15427
370569005209	Helix-turn-helix domains; Region: HTH; cl00088
370569005210	Helix-turn-helix domains; Region: HTH; cl00088
370569005211	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
370569005212	N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581
370569005213	Surface antigen [General function prediction only]; Region: COG3942
370569005214	NlpC/P60 family; Region: NLPC_P60; cl11438
370569005215	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
370569005216	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
370569005217	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
370569005218	dimer interface [polypeptide binding]; other site
370569005219	phosphorylation site [posttranslational modification]
370569005220	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370569005221	ATP binding site [chemical binding]; other site
370569005222	Mg2+ binding site [ion binding]; other site
370569005223	G-X-G motif; other site
370569005224	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
370569005225	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370569005226	active site
370569005227	phosphorylation site [posttranslational modification]
370569005228	intermolecular recognition site; other site
370569005229	dimerization interface [polypeptide binding]; other site
370569005230	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
370569005231	DNA binding site [nucleotide binding]
370569005232	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
370569005233	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
370569005234	FtsX-like permease family; Region: FtsX; cl15850
370569005235	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
370569005236	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
370569005237	Walker A/P-loop; other site
370569005238	ATP binding site [chemical binding]; other site
370569005239	Q-loop/lid; other site
370569005240	ABC transporter signature motif; other site
370569005241	Walker B; other site
370569005242	D-loop; other site
370569005243	H-loop/switch region; other site
370569005244	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
370569005245	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
370569005246	Domain of unknown function (DUF4298); Region: DUF4298; pfam14131
370569005247	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
370569005248	Fibronectin binding repeat; Region: Fn_bind; pfam02986
370569005249	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
370569005250	metal ion-dependent adhesion site (MIDAS); other site
370569005251	Fibronectin binding repeat; Region: Fn_bind; pfam02986
370569005252	Fibronectin binding repeat; Region: Fn_bind; pfam02986
370569005253	foldase protein PrsA; Reviewed; Region: PRK12450
370569005254	Spi protease inhibitor; Region: Inhibitor_I69; pfam13734
370569005255	Spi protease inhibitor; Region: Inhibitor_I69; pfam13734
370569005256	Peptidase C10 family; Region: Peptidase_C10; pfam01640
370569005257	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
370569005258	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
370569005259	DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases.  They exists as monomers and homodimers; Region: NUC; cl00089
370569005260	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
370569005261	tetramer interfaces [polypeptide binding]; other site
370569005262	binuclear metal-binding site [ion binding]; other site
370569005263	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
370569005264	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
370569005265	dimer interface [polypeptide binding]; other site
370569005266	active site
370569005267	metal binding site [ion binding]; metal-binding site
370569005268	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
370569005269	active site
370569005270	intersubunit interactions; other site
370569005271	catalytic residue [active]
370569005272	pyruvate formate-lyase; Region: PFL2-3; TIGR01774
370569005273	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
370569005274	dimer interface [polypeptide binding]; other site
370569005275	active site
370569005276	glycine loop; other site
370569005277	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
370569005278	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
370569005279	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
370569005280	active site
370569005281	P-loop; other site
370569005282	phosphorylation site [posttranslational modification]
370569005283	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
370569005284	active site
370569005285	methionine cluster; other site
370569005286	phosphorylation site [posttranslational modification]
370569005287	metal binding site [ion binding]; metal-binding site
370569005288	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
370569005289	Helix-turn-helix domains; Region: HTH; cl00088
370569005290	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
370569005291	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
370569005292	Helix-turn-helix domains; Region: HTH; cl00088
370569005293	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
370569005294	active site
370569005295	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
370569005296	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370569005297	FeS/SAM binding site; other site
370569005298	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
370569005299	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
370569005300	Transglycosylase; Region: Transgly; cl07896
370569005301	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
370569005302	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
370569005303	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
370569005304	homotrimer interaction site [polypeptide binding]; other site
370569005305	putative active site [active]
370569005306	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
370569005307	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
370569005308	active site
370569005309	Predicted membrane protein [Function unknown]; Region: COG4640
370569005310	Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690
370569005311	Peptidase family C69; Region: Peptidase_C69; pfam03577
370569005312	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370569005313	non-specific DNA binding site [nucleotide binding]; other site
370569005314	salt bridge; other site
370569005315	sequence-specific DNA binding site [nucleotide binding]; other site
370569005316	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
370569005317	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
370569005318	ring oligomerisation interface [polypeptide binding]; other site
370569005319	ATP/Mg binding site [chemical binding]; other site
370569005320	stacking interactions; other site
370569005321	hinge regions; other site
370569005322	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
370569005323	oligomerisation interface [polypeptide binding]; other site
370569005324	mobile loop; other site
370569005325	roof hairpin; other site
370569005326	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
370569005327	Clp amino terminal domain; Region: Clp_N; pfam02861
370569005328	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370569005329	Walker A motif; other site
370569005330	ATP binding site [chemical binding]; other site
370569005331	Walker B motif; other site
370569005332	arginine finger; other site
370569005333	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370569005334	Walker A motif; other site
370569005335	ATP binding site [chemical binding]; other site
370569005336	Walker B motif; other site
370569005337	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
370569005338	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850
370569005339	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
370569005340	DNA-binding site [nucleotide binding]; DNA binding site
370569005341	RNA-binding motif; other site
370569005342	peroxiredoxin; Region: AhpC; TIGR03137
370569005343	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
370569005344	dimer interface [polypeptide binding]; other site
370569005345	decamer (pentamer of dimers) interface [polypeptide binding]; other site
370569005346	catalytic triad [active]
370569005347	peroxidatic and resolving cysteines [active]
370569005348	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
370569005349	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
370569005350	catalytic residue [active]
370569005351	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
370569005352	catalytic residues [active]
370569005353	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569005354	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
370569005355	imidazolonepropionase; Validated; Region: PRK09356
370569005356	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
370569005357	active site
370569005358	urocanate hydratase; Provisional; Region: PRK05414
370569005359	Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643
370569005360	Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837
370569005361	Formiminotransferase domain; Region: FTCD; pfam02971
370569005362	Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350
370569005363	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
370569005364	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
370569005365	Potassium binding sites [ion binding]; other site
370569005366	Cesium cation binding sites [ion binding]; other site
370569005367	HutD; Region: HutD; cl01532
370569005368	amino acid transporter; Region: 2A0306; TIGR00909
370569005369	Spore germination protein; Region: Spore_permease; cl15802
370569005370	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
370569005371	active sites [active]
370569005372	tetramer interface [polypeptide binding]; other site
370569005373	Arginase family; Region: Arginase; cl00306
370569005374	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
370569005375	Predicted ATPase [General function prediction only]; Region: COG3899
370569005376	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569005377	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
370569005378	rRNA interaction site [nucleotide binding]; other site
370569005379	S8 interaction site; other site
370569005380	putative laminin-1 binding site; other site
370569005381	elongation factor Ts; Provisional; Region: tsf; PRK09377
370569005382	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
370569005383	Elongation factor TS; Region: EF_TS; pfam00889
370569005384	Elongation factor TS; Region: EF_TS; pfam00889
370569005385	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
370569005386	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
370569005387	active site
370569005388	Zn binding site [ion binding]; other site
370569005389	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
370569005390	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
370569005391	Ca binding site [ion binding]; other site
370569005392	active site
370569005393	catalytic site [active]
370569005394	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
370569005395	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
370569005396	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
370569005397	active site turn [active]
370569005398	phosphorylation site [posttranslational modification]
370569005399	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
370569005400	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
370569005401	HPr interaction site; other site
370569005402	glycerol kinase (GK) interaction site [polypeptide binding]; other site
370569005403	active site
370569005404	phosphorylation site [posttranslational modification]
370569005405	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
370569005406	DNA-binding site [nucleotide binding]; DNA binding site
370569005407	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
370569005408	UTRA domain; Region: UTRA; cl01230
370569005409	Helix-turn-helix domains; Region: HTH; cl00088
370569005410	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
370569005411	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
370569005412	putative metal binding site [ion binding]; other site
370569005413	Protein of unknown function (DUF328); Region: DUF328; cl01143
370569005414	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
370569005415	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
370569005416	Predicted acetyltransferase [General function prediction only]; Region: COG3981
370569005417	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
370569005418	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
370569005419	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569005420	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
370569005421	ATP cone domain; Region: ATP-cone; pfam03477
370569005422	Class III ribonucleotide reductase; Region: RNR_III; cd01675
370569005423	effector binding site; other site
370569005424	active site
370569005425	Zn binding site [ion binding]; other site
370569005426	glycine loop; other site
370569005427	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
370569005428	Protein of unknown function (DUF1292); Region: DUF1292; cl01608
370569005429	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
370569005430	Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857
370569005431	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
370569005432	ArsC family; Region: ArsC; pfam03960
370569005433	putative catalytic residues [active]
370569005434	thiol/disulfide switch; other site
370569005435	recombinase A; Provisional; Region: recA; PRK09354
370569005436	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
370569005437	hexamer interface [polypeptide binding]; other site
370569005438	Walker A motif; other site
370569005439	ATP binding site [chemical binding]; other site
370569005440	Walker B motif; other site
370569005441	competence damage-inducible protein A; Provisional; Region: PRK00549
370569005442	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
370569005443	putative MPT binding site; other site
370569005444	Competence-damaged protein; Region: CinA; cl00666
370569005445	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
370569005446	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
370569005447	RuvA N terminal domain; Region: RuvA_N; pfam01330
370569005448	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
370569005449	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370569005450	putative substrate translocation pore; other site
370569005451	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
370569005452	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370569005453	ATP binding site [chemical binding]; other site
370569005454	Mg2+ binding site [ion binding]; other site
370569005455	G-X-G motif; other site
370569005456	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
370569005457	ATP binding site [chemical binding]; other site
370569005458	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
370569005459	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
370569005460	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
370569005461	Int/Topo IB signature motif; other site
370569005462	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370569005463	non-specific DNA binding site [nucleotide binding]; other site
370569005464	salt bridge; other site
370569005465	sequence-specific DNA binding site [nucleotide binding]; other site
370569005466	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
370569005467	Prophage antirepressor [Transcription]; Region: COG3617
370569005468	BRO family, N-terminal domain; Region: Bro-N; cl10591
370569005469	Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362
370569005470	D5 N terminal like; Region: D5_N; cl07360
370569005471	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
370569005472	Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371
370569005473	Protein of unknown function (DUF1492); Region: DUF1492; pfam07374
370569005474	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
370569005475	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
370569005476	MutS domain I; Region: MutS_I; pfam01624
370569005477	MutS domain II; Region: MutS_II; pfam05188
370569005478	MutS family domain IV; Region: MutS_IV; pfam05190
370569005479	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
370569005480	Walker A/P-loop; other site
370569005481	ATP binding site [chemical binding]; other site
370569005482	Q-loop/lid; other site
370569005483	ABC transporter signature motif; other site
370569005484	Walker B; other site
370569005485	D-loop; other site
370569005486	H-loop/switch region; other site
370569005487	Protein of unknown function (DUF964); Region: DUF964; cl01483
370569005488	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
370569005489	arginine repressor; Region: argR_whole; TIGR01529
370569005490	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
370569005491	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
370569005492	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
370569005493	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
370569005494	active site
370569005495	HIGH motif; other site
370569005496	KMSK motif region; other site
370569005497	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
370569005498	tRNA binding surface [nucleotide binding]; other site
370569005499	anticodon binding site; other site
370569005500	Enterocin A Immunity; Region: EntA_Immun; pfam08951
370569005501	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
370569005502	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
370569005503	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
370569005504	Uncharacterized conserved protein [Function unknown]; Region: COG1284
370569005505	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
370569005506	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
370569005507	Uncharacterized conserved protein [Function unknown]; Region: COG1284
370569005508	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
370569005509	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
370569005510	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
370569005511	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
370569005512	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
370569005513	dimer interface [polypeptide binding]; other site
370569005514	anticodon binding site; other site
370569005515	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
370569005516	homodimer interface [polypeptide binding]; other site
370569005517	motif 1; other site
370569005518	active site
370569005519	motif 2; other site
370569005520	GAD domain; Region: GAD; pfam02938
370569005521	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
370569005522	motif 3; other site
370569005523	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
370569005524	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
370569005525	dimer interface [polypeptide binding]; other site
370569005526	motif 1; other site
370569005527	active site
370569005528	motif 2; other site
370569005529	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
370569005530	anticodon binding site; other site
370569005531	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
370569005532	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
370569005533	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
370569005534	Cadmium resistance transporter; Region: Cad; cl04177
370569005535	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
370569005536	putative DNA binding site [nucleotide binding]; other site
370569005537	putative Zn2+ binding site [ion binding]; other site
370569005538	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569005539	AAA domain; Region: AAA_22; pfam13401
370569005540	Domain of unknown function (DUF368); Region: DUF368; cl00893
370569005541	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
370569005542	putative active site [active]
370569005543	putative CoA binding site [chemical binding]; other site
370569005544	nudix motif; other site
370569005545	metal binding site [ion binding]; metal-binding site
370569005546	Helix-turn-helix domains; Region: HTH; cl00088
370569005547	Protein of unknown function (DUF1700); Region: DUF1700; cl01933
370569005548	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
370569005549	Predicted membrane protein [Function unknown]; Region: COG1511
370569005550	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
370569005551	ABC-2 type transporter; Region: ABC2_membrane; cl11417
370569005552	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
370569005553	Helix-turn-helix domains; Region: HTH; cl00088
370569005554	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
370569005555	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
370569005556	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
370569005557	RNA binding surface [nucleotide binding]; other site
370569005558	Protein of unknown function (DUF1021); Region: DUF1021; cl01852
370569005559	replicative DNA helicase; Provisional; Region: PRK05748
370569005560	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
370569005561	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
370569005562	Walker A motif; other site
370569005563	ATP binding site [chemical binding]; other site
370569005564	Walker B motif; other site
370569005565	DNA binding loops [nucleotide binding]
370569005566	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
370569005567	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
370569005568	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
370569005569	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
370569005570	DHH family; Region: DHH; pfam01368
370569005571	DHHA1 domain; Region: DHHA1; pfam02272
370569005572	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
370569005573	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370569005574	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
370569005575	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
370569005576	nudix motif; other site
370569005577	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
370569005578	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
370569005579	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
370569005580	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
370569005581	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
370569005582	putative L-serine binding site [chemical binding]; other site
370569005583	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
370569005584	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
370569005585	Cobalt transport protein; Region: CbiQ; cl00463
370569005586	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649
370569005587	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
370569005588	Walker A/P-loop; other site
370569005589	ATP binding site [chemical binding]; other site
370569005590	Q-loop/lid; other site
370569005591	ABC transporter signature motif; other site
370569005592	Walker B; other site
370569005593	D-loop; other site
370569005594	H-loop/switch region; other site
370569005595	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650
370569005596	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
370569005597	Walker A/P-loop; other site
370569005598	ATP binding site [chemical binding]; other site
370569005599	Q-loop/lid; other site
370569005600	ABC transporter signature motif; other site
370569005601	Walker B; other site
370569005602	D-loop; other site
370569005603	H-loop/switch region; other site
370569005604	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
370569005605	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
370569005606	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
370569005607	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
370569005608	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
370569005609	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
370569005610	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
370569005611	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
370569005612	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
370569005613	recombination protein F; Reviewed; Region: recF; PRK00064
370569005614	RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage.  When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242
370569005615	Walker A/P-loop; other site
370569005616	ATP binding site [chemical binding]; other site
370569005617	Q-loop/lid; other site
370569005618	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569005619	ABC transporter signature motif; other site
370569005620	Walker B; other site
370569005621	D-loop; other site
370569005622	H-loop/switch region; other site
370569005623	Sugar transport protein; Region: Sugar_transport; pfam06800
370569005624	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
370569005625	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
370569005626	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
370569005627	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
370569005628	active site
370569005629	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
370569005630	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
370569005631	active site
370569005632	HIGH motif; other site
370569005633	dimer interface [polypeptide binding]; other site
370569005634	KMSKS motif; other site
370569005635	Uncharacterized conserved protein [Function unknown]; Region: COG1284
370569005636	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
370569005637	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
370569005638	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
370569005639	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
370569005640	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
370569005641	Walker A/P-loop; other site
370569005642	ATP binding site [chemical binding]; other site
370569005643	Q-loop/lid; other site
370569005644	ABC transporter signature motif; other site
370569005645	Walker B; other site
370569005646	D-loop; other site
370569005647	H-loop/switch region; other site
370569005648	ABC transporter; Region: ABC_tran_2; pfam12848
370569005649	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
370569005650	Predicted membrane protein [Function unknown]; Region: COG4485
370569005651	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
370569005652	Helix-turn-helix domains; Region: HTH; cl00088
370569005653	Integrase core domain; Region: rve; cl01316
370569005654	Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679
370569005655	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590
370569005656	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
370569005657	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
370569005658	protein binding site [polypeptide binding]; other site
370569005659	ParB-like partition proteins; Region: parB_part; TIGR00180
370569005660	ParB-like nuclease domain; Region: ParBc; cl02129
370569005661	Helix-turn-helix domains; Region: HTH; cl00088