-- dump date 20120504_162934 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_599597.1 94991498 4064499 202..1557 1 NC_008023.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1557 dnaA 4064499 dnaA Streptococcus pyogenes MGAS2096 chromosomal replication initiation protein YP_599597.1 202 D 370565 CDS YP_599598.1 94991499 4064500 1712..2848 1 NC_008023.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 2848 dnaN 4064500 dnaN Streptococcus pyogenes MGAS2096 DNA polymerase III subunit beta YP_599598.1 1712 D 370565 CDS YP_599599.1 94991500 4064501 2923..3120 1 NC_008023.1 putative cytoplasmic protein 3120 4064501 MGAS2096_Spy0003 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_599599.1 2923 D 370565 CDS YP_599600.1 94991501 4066442 3450..4565 1 NC_008023.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 4565 4066442 MGAS2096_Spy0004 Streptococcus pyogenes MGAS2096 GTP-dependent nucleic acid-binding protein EngD YP_599600.1 3450 D 370565 CDS YP_599601.1 94991502 4066443 4590..5204 1 NC_008023.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 5204 pth 4066443 pth Streptococcus pyogenes MGAS2096 peptidyl-tRNA hydrolase YP_599601.1 4590 D 370565 CDS YP_599602.1 94991503 4066444 5207..8710 1 NC_008023.1 transcription-repair coupling factor 8710 trcF 4066444 trcF Streptococcus pyogenes MGAS2096 transcription-repair coupling factor YP_599602.1 5207 D 370565 CDS YP_599603.1 94991504 4066445 8872..9144 1 NC_008023.1 heat shock protein 15 9144 4066445 MGAS2096_Spy0007 Streptococcus pyogenes MGAS2096 heat shock protein 15 YP_599603.1 8872 D 370565 CDS YP_599604.1 94991505 4066446 9131..9502 1 NC_008023.1 cell division protein DIVIC 9502 divIC 4066446 divIC Streptococcus pyogenes MGAS2096 cell division protein DIVIC YP_599604.1 9131 D 370565 CDS YP_599605.1 94991506 4066447 9499..9624 1 NC_008023.1 hypothetical protein 9624 4066447 MGAS2096_Spy0009 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599605.1 9499 D 370565 CDS YP_599606.1 94991507 4066448 9637..10923 1 NC_008023.1 Beta-lactamase 10923 4066448 MGAS2096_Spy0010 Streptococcus pyogenes MGAS2096 Beta-lactamase YP_599606.1 9637 D 370565 CDS YP_599607.1 94991508 4066449 10920..12206 1 NC_008023.1 tRNA(Ile)-lysidine synthetase TilS 12206 tilS 4066449 tilS Streptococcus pyogenes MGAS2096 tRNA(Ile)-lysidine synthetase TilS YP_599607.1 10920 D 370565 CDS YP_599608.1 94991509 4066450 12211..12753 1 NC_008023.1 hypoxanthine-guanine phosphoribosyltransferase 12753 4066450 MGAS2096_Spy0012 Streptococcus pyogenes MGAS2096 hypoxanthine-guanine phosphoribosyltransferase YP_599608.1 12211 D 370565 CDS YP_599609.1 94991510 4066451 12775..13155 1 NC_008023.1 cell division protein ftsH 13155 4066451 MGAS2096_Spy0013 Streptococcus pyogenes MGAS2096 cell division protein ftsH YP_599609.1 12775 D 370565 CDS YP_599610.1 94991511 4066452 13133..14755 1 NC_008023.1 cell division protein ftsH 14755 ftsH 4066452 ftsH Streptococcus pyogenes MGAS2096 cell division protein ftsH YP_599610.1 13133 D 370565 CDS YP_599611.1 94991512 4066453 15013..16473 1 NC_008023.1 amino acid permease 16473 4066453 MGAS2096_Spy0015 Streptococcus pyogenes MGAS2096 amino acid permease YP_599611.1 15013 D 370565 CDS YP_599612.1 94991513 4066454 complement(16815..16949) 1 NC_008023.1 hypothetical protein 16949 4066454 MGAS2096_Spy0016 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599612.1 16815 R 370565 CDS YP_599613.1 94991514 4065245 complement(30142..30348) 1 NC_008023.1 transposase 30348 4065245 MGAS2096_Spy0017 Streptococcus pyogenes MGAS2096 transposase YP_599613.1 30142 R 370565 CDS YP_599614.1 94991515 4065246 30845..32041 1 NC_008023.1 hypothetical protein 32041 sibA 4065246 sibA Streptococcus pyogenes MGAS2096 hypothetical protein YP_599614.1 30845 D 370565 CDS YP_599615.1 94991516 4065247 32282..33256 1 NC_008023.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 33256 prsA2 4065247 prsA2 Streptococcus pyogenes MGAS2096 ribose-phosphate pyrophosphokinase YP_599615.1 32282 D 370565 CDS YP_599616.1 94991517 4065248 33442..34197 1 NC_008023.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 34197 recO 4065248 recO Streptococcus pyogenes MGAS2096 DNA repair protein RecO YP_599616.1 33442 D 370565 CDS YP_599617.1 94991518 4065249 34222..35307 1 NC_008023.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; putative glycerol-3-phosphate acyltransferase PlsX 35307 plsX 4065249 plsX Streptococcus pyogenes MGAS2096 putative glycerol-3-phosphate acyltransferase PlsX YP_599617.1 34222 D 370565 CDS YP_599618.1 94991519 4065250 35300..35542 1 NC_008023.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 35542 acpP2 4065250 acpP2 Streptococcus pyogenes MGAS2096 acyl carrier protein YP_599618.1 35300 D 370565 CDS YP_599619.1 94991520 4065251 35663..36397 1 NC_008023.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 36397 4065251 MGAS2096_Spy0023 Streptococcus pyogenes MGAS2096 phosphoribosylaminoimidazole-succinocarboxamide synthase YP_599619.1 35663 D 370565 CDS YP_599620.1 94991521 4065252 36473..40246 1 NC_008023.1 phosphoribosylformylglycinamidine synthase 40246 4065252 MGAS2096_Spy0024 Streptococcus pyogenes MGAS2096 phosphoribosylformylglycinamidine synthase YP_599620.1 36473 D 370565 CDS YP_599621.1 94991522 4065253 40350..41861 1 NC_008023.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 41861 purF 4065253 purF Streptococcus pyogenes MGAS2096 amidophosphoribosyltransferase YP_599621.1 40350 D 370565 CDS YP_599622.1 94991523 4065254 41889..42911 1 NC_008023.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 42911 purM 4065254 purM Streptococcus pyogenes MGAS2096 phosphoribosylaminoimidazole synthetase YP_599622.1 41889 D 370565 CDS YP_599623.1 94991524 4065255 43079..43633 1 NC_008023.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 43633 purN 4065255 purN Streptococcus pyogenes MGAS2096 phosphoribosylglycinamide formyltransferase YP_599623.1 43079 D 370565 CDS YP_599624.1 94991525 4065256 43817..45364 1 NC_008023.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 45364 purH 4065256 purH Streptococcus pyogenes MGAS2096 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_599624.1 43817 D 370565 CDS YP_599625.1 94991526 4065257 complement(45422..46546) 1 NC_008023.1 autolysin 46546 4065257 MGAS2096_Spy0029 Streptococcus pyogenes MGAS2096 autolysin YP_599625.1 45422 R 370565 CDS YP_599626.1 94991527 4065258 46652..48064 1 NC_008023.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 48064 purD 4065258 purD Streptococcus pyogenes MGAS2096 phosphoribosylamine--glycine ligase YP_599626.1 46652 D 370565 CDS YP_599627.1 94991528 4065259 48342..48833 1 NC_008023.1 phosphoribosylaminoimidazole carboxylase catalytic subunit 48833 purE 4065259 purE Streptococcus pyogenes MGAS2096 phosphoribosylaminoimidazole carboxylase catalytic subunit YP_599627.1 48342 D 370565 CDS YP_599628.1 94991529 4065260 48784..49893 1 NC_008023.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 49893 purK 4065260 purK Streptococcus pyogenes MGAS2096 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_599628.1 48784 D 370565 CDS YP_599629.1 94991530 4065261 49914..51254 1 NC_008023.1 putative cytoplasmic protein 51254 4065261 MGAS2096_Spy0033 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_599629.1 49914 D 370565 CDS YP_599630.1 94991531 4065262 complement(51255..51413) 1 NC_008023.1 hypothetical protein 51413 4065262 MGAS2096_Spy0034 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599630.1 51255 R 370565 CDS YP_599631.1 94991532 4065263 51623..52915 1 NC_008023.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 52915 purB 4065263 purB Streptococcus pyogenes MGAS2096 adenylosuccinate lyase YP_599631.1 51623 D 370565 CDS YP_599632.1 94991533 4066203 53048..53959 1 NC_008023.1 transcriptional regulator 53959 4066203 MGAS2096_Spy0036 Streptococcus pyogenes MGAS2096 transcriptional regulator YP_599632.1 53048 D 370565 CDS YP_599633.1 94991534 4066204 54113..55183 1 NC_008023.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 55183 ruvB 4066204 ruvB Streptococcus pyogenes MGAS2096 Holliday junction DNA helicase RuvB YP_599633.1 54113 D 370565 CDS YP_599634.1 94991535 4066205 55321..55758 1 NC_008023.1 protein tyrosine phosphatase 55758 4066205 MGAS2096_Spy0038 Streptococcus pyogenes MGAS2096 protein tyrosine phosphatase YP_599634.1 55321 D 370565 CDS YP_599635.1 94991536 4066206 55782..56183 1 NC_008023.1 hypothetical protein 56183 4066206 MGAS2096_Spy0039 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599635.1 55782 D 370565 CDS YP_599636.1 94991537 4066207 56180..57955 1 NC_008023.1 acyltransferase 57955 4066207 MGAS2096_Spy0040 Streptococcus pyogenes MGAS2096 acyltransferase YP_599636.1 56180 D 370565 CDS YP_599637.1 94991538 4066208 58265..60907 1 NC_008023.1 bifunctional; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 60907 4066208 MGAS2096_Spy0041 Streptococcus pyogenes MGAS2096 bifunctional acetaldehyde-CoA/alcohol dehydrogenase YP_599637.1 58265 D 370565 CDS YP_599638.1 94991539 4066209 61102..61566 1 NC_008023.1 alcohol dehydrogenase 61566 adhA 4066209 adhA Streptococcus pyogenes MGAS2096 alcohol dehydrogenase YP_599638.1 61102 D 370565 CDS YP_599639.1 94991540 4066210 61735..62028 1 NC_008023.1 alcohol dehydrogenase 62028 4066210 MGAS2096_Spy0043 Streptococcus pyogenes MGAS2096 alcohol dehydrogenase YP_599639.1 61735 D 370565 CDS YP_599640.1 94991541 4066211 61958..62176 1 NC_008023.1 alcohol dehydrogenase 62176 4066211 MGAS2096_Spy0044 Streptococcus pyogenes MGAS2096 alcohol dehydrogenase YP_599640.1 61958 D 370565 CDS YP_599641.1 94991542 4066212 62564..63853 1 NC_008023.1 Na+ driven multidrug efflux pump 63853 4066212 MGAS2096_Spy0045 Streptococcus pyogenes MGAS2096 Na+ driven multidrug efflux pump YP_599641.1 62564 D 370565 CDS YP_599642.1 94991543 4066213 64052..64360 1 NC_008023.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 64360 rpsJ 4066213 rpsJ Streptococcus pyogenes MGAS2096 30S ribosomal protein S10 YP_599642.1 64052 D 370565 CDS YP_599643.1 94991544 4066214 64608..65234 1 NC_008023.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 65234 rplC 4066214 rplC Streptococcus pyogenes MGAS2096 50S ribosomal protein L3 YP_599643.1 64608 D 370565 CDS YP_599644.1 94991545 4066215 65258..65587 1 NC_008023.1 50S ribosomal protein L1E (L4P) 65587 4066215 MGAS2096_Spy0048 Streptococcus pyogenes MGAS2096 50S ribosomal protein L1E (L4P) YP_599644.1 65258 D 370565 CDS YP_599645.1 94991546 4066216 65584..65880 1 NC_008023.1 50S ribosomal protein L1E (L4P) 65880 rplD 4066216 rplD Streptococcus pyogenes MGAS2096 50S ribosomal protein L1E (L4P) YP_599645.1 65584 D 370565 CDS YP_599646.1 94991547 4066217 65880..66176 1 NC_008023.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 66176 rplW 4066217 rplW Streptococcus pyogenes MGAS2096 50S ribosomal protein L23 YP_599646.1 65880 D 370565 CDS YP_599647.1 94991548 4066218 66194..67027 1 NC_008023.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 67027 rplB 4066218 rplB Streptococcus pyogenes MGAS2096 50S ribosomal protein L2 YP_599647.1 66194 D 370565 CDS YP_599648.2 162139140 4066219 67167..67445 1 NC_008023.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 67445 rpsS 4066219 rpsS Streptococcus pyogenes MGAS2096 30S ribosomal protein S19 YP_599648.2 67167 D 370565 CDS YP_599649.1 94991550 4066220 67461..67805 1 NC_008023.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 67805 rplV 4066220 rplV Streptococcus pyogenes MGAS2096 50S ribosomal protein L22 YP_599649.1 67461 D 370565 CDS YP_599650.1 94991551 4066221 67818..68471 1 NC_008023.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 68471 rpsC 4066221 rpsC Streptococcus pyogenes MGAS2096 30S ribosomal protein S3 YP_599650.1 67818 D 370565 CDS YP_599651.1 94991552 4064883 68475..68888 1 NC_008023.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 68888 rplP 4064883 rplP Streptococcus pyogenes MGAS2096 50S ribosomal protein L16 YP_599651.1 68475 D 370565 CDS YP_599652.1 94991553 4064884 68898..69104 1 NC_008023.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 69104 rpmC 4064884 rpmC Streptococcus pyogenes MGAS2096 50S ribosomal protein L29 YP_599652.1 68898 D 370565 CDS YP_599653.1 94991554 4064885 69130..69390 1 NC_008023.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 69390 rpsQ 4064885 rpsQ Streptococcus pyogenes MGAS2096 30S ribosomal protein S17 YP_599653.1 69130 D 370565 CDS YP_599654.1 94991555 4064886 69415..69783 1 NC_008023.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 69783 rplN 4064886 rplN Streptococcus pyogenes MGAS2096 50S ribosomal protein L14 YP_599654.1 69415 D 370565 CDS YP_599655.1 94991556 4064887 69865..70170 1 NC_008023.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 70170 rplX 4064887 rplX Streptococcus pyogenes MGAS2096 50S ribosomal protein L24 YP_599655.1 69865 D 370565 CDS YP_599656.1 94991557 4064888 70194..70736 1 NC_008023.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 70736 rplE 4064888 rplE Streptococcus pyogenes MGAS2096 50S ribosomal protein L5 YP_599656.1 70194 D 370565 CDS YP_599657.1 94991558 4064889 71087..71485 1 NC_008023.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 71485 rpsH 4064889 rpsH Streptococcus pyogenes MGAS2096 30S ribosomal protein S8 YP_599657.1 71087 D 370565 CDS YP_599658.1 94991559 4064890 71688..72224 1 NC_008023.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 72224 rplF 4064890 rplF Streptococcus pyogenes MGAS2096 50S ribosomal protein L6 YP_599658.1 71688 D 370565 CDS YP_599659.1 94991560 4064891 72320..72685 1 NC_008023.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 72685 rplR 4064891 rplR Streptococcus pyogenes MGAS2096 50S ribosomal protein L18 YP_599659.1 72320 D 370565 CDS YP_599660.1 94991561 4064892 72704..73198 1 NC_008023.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 73198 rpsE 4064892 rpsE Streptococcus pyogenes MGAS2096 30S ribosomal protein S5 YP_599660.1 72704 D 370565 CDS YP_599661.1 94991562 4064893 73213..73395 1 NC_008023.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 73395 rpmD 4064893 rpmD Streptococcus pyogenes MGAS2096 50S ribosomal protein L30 YP_599661.1 73213 D 370565 CDS YP_599662.1 94991563 4064894 73610..74050 1 NC_008023.1 late assembly protein; 50S ribosomal protein L15 74050 rplO 4064894 rplO Streptococcus pyogenes MGAS2096 50S ribosomal protein L15 YP_599662.1 73610 D 370565 CDS YP_599663.2 162139139 4064895 74067..75371 1 NC_008023.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 75371 secY 4064895 secY Streptococcus pyogenes MGAS2096 preprotein translocase subunit SecY YP_599663.2 74067 D 370565 CDS YP_599664.1 94991565 4064896 75521..76159 1 NC_008023.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 76159 adk 4064896 adk Streptococcus pyogenes MGAS2096 adenylate kinase YP_599664.1 75521 D 370565 CDS YP_599665.1 94991566 4064897 76223..76495 1 NC_008023.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 76495 infA 4064897 infA Streptococcus pyogenes MGAS2096 translation initiation factor IF-1 YP_599665.1 76223 D 370565 CDS YP_599666.1 94991567 4064898 76521..76637 1 NC_008023.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 76637 rpmJ 4064898 rpmJ Streptococcus pyogenes MGAS2096 50S ribosomal protein L36 YP_599666.1 76521 D 370565 CDS YP_599667.1 94991568 4064899 76655..77020 1 NC_008023.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 77020 rpsM 4064899 rpsM Streptococcus pyogenes MGAS2096 30S ribosomal protein S13 YP_599667.1 76655 D 370565 CDS YP_599668.1 94991569 4064900 77038..77421 1 NC_008023.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 77421 rpsK 4064900 rpsK Streptococcus pyogenes MGAS2096 30S ribosomal protein S11 YP_599668.1 77038 D 370565 CDS YP_599669.1 94991570 4064901 77467..78405 1 NC_008023.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 78405 rpoA 4064901 rpoA Streptococcus pyogenes MGAS2096 DNA-directed RNA polymerase subunit alpha YP_599669.1 77467 D 370565 CDS YP_599670.1 94991571 4064902 78420..78806 1 NC_008023.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 78806 rplQ 4064902 rplQ Streptococcus pyogenes MGAS2096 50S ribosomal protein L17 YP_599670.1 78420 D 370565 CDS YP_599671.1 94991572 4065332 complement(79402..79536) 1 NC_008023.1 hypothetical protein 79536 4065332 MGAS2096_Spy0075 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599671.1 79402 R 370565 CDS YP_599672.1 94991573 4066371 86048..86233 1 NC_008023.1 hypothetical protein 86233 4066371 MGAS2096_Spy0076 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599672.1 86048 D 370565 CDS YP_599673.1 94991574 4066372 86737..86841 1 NC_008023.1 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 86841 4066372 MGAS2096_Spy0077 Streptococcus pyogenes MGAS2096 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_599673.1 86737 D 370565 CDS YP_599674.1 94991575 4066373 86872..87180 1 NC_008023.1 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 87180 4066373 MGAS2096_Spy0078 Streptococcus pyogenes MGAS2096 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_599674.1 86872 D 370565 CDS YP_599675.1 94991576 4066374 87220..87447 1 NC_008023.1 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 87447 4066374 MGAS2096_Spy0079 Streptococcus pyogenes MGAS2096 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_599675.1 87220 D 370565 CDS YP_599676.1 94991577 4066375 87557..88000 1 NC_008023.1 MarR family transcriptional regulator 88000 adcR 4066375 adcR Streptococcus pyogenes MGAS2096 MarR family transcriptional regulator YP_599676.1 87557 D 370565 CDS YP_599677.1 94991578 4066376 88004..88723 1 NC_008023.1 high-affinity zinc uptake system ATP-binding protein znuC 88723 adcC 4066376 adcC Streptococcus pyogenes MGAS2096 high-affinity zinc uptake system ATP-binding protein znuC YP_599677.1 88004 D 370565 CDS YP_599678.1 94991579 4066377 88677..89531 1 NC_008023.1 high-affinity zinc uptake system membrane protein znuB 89531 adcB 4066377 adcB Streptococcus pyogenes MGAS2096 high-affinity zinc uptake system membrane protein znuB YP_599678.1 88677 D 370565 CDS YP_599679.1 94991580 4065479 complement(89571..89954) 1 NC_008023.1 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) 89954 4065479 MGAS2096_Spy0083 Streptococcus pyogenes MGAS2096 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) YP_599679.1 89571 R 370565 CDS YP_599680.1 94991581 4065480 complement(90006..91262) 1 NC_008023.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 91262 tyrS 4065480 tyrS Streptococcus pyogenes MGAS2096 tyrosyl-tRNA synthetase YP_599680.1 90006 R 370565 CDS YP_599681.1 94991582 4065481 91354..93666 1 NC_008023.1 multimodular transpeptidase-transglycosylase PBP 1B 93666 pbp1b 4065481 pbp1b Streptococcus pyogenes MGAS2096 multimodular transpeptidase-transglycosylase PBP 1B YP_599681.1 91354 D 370565 CDS YP_599682.1 94991583 4065482 93930..97496 1 NC_008023.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 97496 rpoB 4065482 rpoB Streptococcus pyogenes MGAS2096 DNA-directed RNA polymerase subunit beta YP_599682.1 93930 D 370565 CDS YP_599683.1 94991584 4065483 97587..101210 1 NC_008023.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 101210 rpoC 4065483 rpoC Streptococcus pyogenes MGAS2096 DNA-directed RNA polymerase subunit beta' YP_599683.1 97587 D 370565 CDS YP_599684.1 94991585 4065484 101362..101727 1 NC_008023.1 putative DNA binding protein 101727 4065484 MGAS2096_Spy0088 Streptococcus pyogenes MGAS2096 putative DNA binding protein YP_599684.1 101362 D 370565 CDS YP_599685.1 94991586 4065485 101820..102758 1 NC_008023.1 ComG operon protein 1 102758 comYA 4065485 comYA Streptococcus pyogenes MGAS2096 ComG operon protein 1 YP_599685.1 101820 D 370565 CDS YP_599686.1 94991587 4065486 102637..103728 1 NC_008023.1 ComG operon protein 2 103728 comYB 4065486 comYB Streptococcus pyogenes MGAS2096 ComG operon protein 2 YP_599686.1 102637 D 370565 CDS YP_599687.1 94991588 4065487 103730..104056 1 NC_008023.1 ComG operon protein 3 104056 comYC 4065487 comYC Streptococcus pyogenes MGAS2096 ComG operon protein 3 YP_599687.1 103730 D 370565 CDS YP_599688.1 94991589 4065488 104031..104459 1 NC_008023.1 ComG operon protein 4 104459 4065488 MGAS2096_Spy0092 Streptococcus pyogenes MGAS2096 ComG operon protein 4 YP_599688.1 104031 D 370565 CDS YP_599689.1 94991590 4065489 104416..104700 1 NC_008023.1 hypothetical protein 104700 4065489 MGAS2096_Spy0093 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599689.1 104416 D 370565 CDS YP_599690.1 94991591 4065490 104693..105127 1 NC_008023.1 ComG operon protein 6 105127 comYD 4065490 comYD Streptococcus pyogenes MGAS2096 ComG operon protein 6 YP_599690.1 104693 D 370565 CDS YP_599691.1 94991592 4065491 105111..105437 1 NC_008023.1 ComG operon protein 6 105437 4065491 MGAS2096_Spy0095 Streptococcus pyogenes MGAS2096 ComG operon protein 6 YP_599691.1 105111 D 370565 CDS YP_599692.1 94991593 4065492 105490..106488 1 NC_008023.1 adenine-specific methyltransferase 106488 4065492 MGAS2096_Spy0096 Streptococcus pyogenes MGAS2096 adenine-specific methyltransferase YP_599692.1 105490 D 370565 CDS YP_599693.1 94991594 4065493 106547..107743 1 NC_008023.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 107743 ackA 4065493 ackA Streptococcus pyogenes MGAS2096 acetate kinase YP_599693.1 106547 D 370565 CDS YP_599694.1 94991595 4065494 107930..108238 1 NC_008023.1 hypothetical protein 108238 4065494 MGAS2096_Spy0098 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599694.1 107930 D 370565 CDS YP_599695.1 94991596 4065495 complement(108321..109091) 1 NC_008023.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 109091 proC 4065495 proC Streptococcus pyogenes MGAS2096 pyrroline-5-carboxylate reductase YP_599695.1 108321 R 370565 CDS YP_599696.1 94991597 4065496 complement(109139..110206) 1 NC_008023.1 glutamyl aminopeptidase 110206 pepA 4065496 pepA Streptococcus pyogenes MGAS2096 glutamyl aminopeptidase YP_599696.1 109139 R 370565 CDS YP_599697.1 94991598 4065497 complement(110316..110480) 1 NC_008023.1 hypothetical protein 110480 4065497 MGAS2096_Spy0101 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599697.1 110316 R 370565 CDS YP_599698.1 94991599 4065498 110662..110952 1 NC_008023.1 hypothetical protein 110952 4065498 MGAS2096_Spy0102 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599698.1 110662 D 370565 CDS YP_599699.1 94991600 4065499 110949..111269 1 NC_008023.1 thioredoxin 111269 4065499 MGAS2096_Spy0103 Streptococcus pyogenes MGAS2096 thioredoxin YP_599699.1 110949 D 370565 CDS YP_599700.1 94991601 4065500 111287..111913 1 NC_008023.1 tRNA-binding domain-containing protein 111913 4065500 MGAS2096_Spy0104 Streptococcus pyogenes MGAS2096 tRNA-binding domain-containing protein YP_599700.1 111287 D 370565 CDS YP_599701.1 94991602 4065501 112065..112460 1 NC_008023.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 112460 4065501 MGAS2096_Spy0105 Streptococcus pyogenes MGAS2096 single-stranded DNA-binding protein YP_599701.1 112065 D 370565 CDS YP_599702.1 94991603 4065502 complement(112720..113409) 1 NC_008023.1 bifunctional; deoxyadenosine kinase / deoxyguanosine kinase 113409 4065502 MGAS2096_Spy0106 Streptococcus pyogenes MGAS2096 deoxyadenosine kinase / deoxyguanosine kinase YP_599702.1 112720 R 370565 CDS YP_599703.1 94991604 4065503 complement(113381..114430) 1 NC_008023.1 tRNA-dihydrouridine synthase 114430 4065503 MGAS2096_Spy0107 Streptococcus pyogenes MGAS2096 tRNA-dihydrouridine synthase YP_599703.1 113381 R 370565 CDS YP_599704.1 94991605 4065504 complement(114345..115217) 1 NC_008023.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 115217 hslO 4065504 hslO Streptococcus pyogenes MGAS2096 Hsp33-like chaperonin YP_599704.1 114345 R 370565 CDS YP_599705.1 94991606 4065505 complement(115364..116956) 1 NC_008023.1 transcriptional regulator RofA 116956 rofA 4065505 rofA Streptococcus pyogenes MGAS2096 transcriptional regulator RofA YP_599705.1 115364 R 370565 CDS YP_599706.1 94991607 4065506 117089..119185 1 NC_008023.1 fibronectin-binding protein 119185 4065506 MGAS2096_Spy0110 Streptococcus pyogenes MGAS2096 fibronectin-binding protein YP_599706.1 117089 D 370565 CDS YP_599707.1 94991608 4065507 119409..119714 1 NC_008023.1 sortase 119714 4065507 MGAS2096_Spy0111 Streptococcus pyogenes MGAS2096 sortase YP_599707.1 119409 D 370565 CDS YP_599708.1 94991609 4065508 119721..120257 1 NC_008023.1 sortase 120257 4065508 MGAS2096_Spy0112 Streptococcus pyogenes MGAS2096 sortase YP_599708.1 119721 D 370565 CDS YP_599709.1 94991610 4065509 120543..122813 1 NC_008023.1 fibronectin-binding protein 122813 4065509 MGAS2096_Spy0113 Streptococcus pyogenes MGAS2096 fibronectin-binding protein YP_599709.1 120543 D 370565 CDS YP_599710.1 94991611 4065510 122806..123327 1 NC_008023.1 Signal peptidase I 123327 4065510 MGAS2096_Spy0114 Streptococcus pyogenes MGAS2096 Signal peptidase I YP_599710.1 122806 D 370565 CDS YP_599711.1 94991612 4065511 123334..124377 1 NC_008023.1 fibronectin-binding protein 124377 4065511 MGAS2096_Spy0115 Streptococcus pyogenes MGAS2096 fibronectin-binding protein YP_599711.1 123334 D 370565 CDS YP_599712.1 94991613 4065512 124378..125118 1 NC_008023.1 sortase 125118 eftLSL-B 4065512 eftLSL-B Streptococcus pyogenes MGAS2096 sortase YP_599712.1 124378 D 370565 CDS YP_599713.1 94991614 4065513 125063..125722 1 NC_008023.1 hypothetical protein 125722 4065513 MGAS2096_Spy0117 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599713.1 125063 D 370565 CDS YP_599714.1 94991615 4065514 complement(125881..127086) 1 NC_008023.1 AraC family transcriptional regulator 127086 4065514 MGAS2096_Spy0118 Streptococcus pyogenes MGAS2096 AraC family transcriptional regulator YP_599714.1 125881 R 370565 CDS YP_599715.1 94991616 4065515 127471..130956 1 NC_008023.1 collagen adhesion protein 130956 4065515 MGAS2096_Spy0119 Streptococcus pyogenes MGAS2096 collagen adhesion protein YP_599715.1 127471 D 370565 CDS YP_599716.1 94991617 4065516 complement(131223..131888) 1 NC_008023.1 hypothetical protein 131888 4065516 MGAS2096_Spy0120 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599716.1 131223 R 370565 CDS YP_599717.1 94991618 4065517 132208..133647 1 NC_008023.1 Short-chain fatty acids transporter 133647 atoE 4065517 atoE Streptococcus pyogenes MGAS2096 Short-chain fatty acids transporter YP_599717.1 132208 D 370565 CDS YP_599718.1 94991619 4065634 complement(133715..134626) 1 NC_008023.1 LysR family transcriptional regulator 134626 4065634 MGAS2096_Spy0122 Streptococcus pyogenes MGAS2096 LysR family transcriptional regulator YP_599718.1 133715 R 370565 CDS YP_599719.1 94991620 4065635 134747..135931 1 NC_008023.1 Acetyl-CoA acetyltransferase 135931 4065635 MGAS2096_Spy0123 Streptococcus pyogenes MGAS2096 Acetyl-CoA acetyltransferase YP_599719.1 134747 D 370565 CDS YP_599720.1 94991621 4065636 135886..136602 1 NC_008023.1 acetate CoA-transferase subunit alpha 136602 atoD2 4065636 atoD2 Streptococcus pyogenes MGAS2096 acetate CoA-transferase subunit alpha YP_599720.1 135886 D 370565 CDS YP_599721.1 94991622 4065637 136605..137252 1 NC_008023.1 acetate CoA-transferase subunit beta 137252 4065637 MGAS2096_Spy0125 Streptococcus pyogenes MGAS2096 acetate CoA-transferase subunit beta YP_599721.1 136605 D 370565 CDS YP_599722.1 94991623 4065638 complement(137232..137390) 1 NC_008023.1 hypothetical protein 137390 4065638 MGAS2096_Spy0126 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599722.1 137232 R 370565 CDS YP_599723.1 94991624 4065639 complement(137374..138054) 1 NC_008023.1 putative DNA-binding protein 138054 4065639 MGAS2096_Spy0127 Streptococcus pyogenes MGAS2096 putative DNA-binding protein YP_599723.1 137374 R 370565 CDS YP_599724.1 94991625 4065640 138228..138593 1 NC_008023.1 translation initiation inhibitor 138593 4065640 MGAS2096_Spy0128 Streptococcus pyogenes MGAS2096 translation initiation inhibitor YP_599724.1 138228 D 370565 CDS YP_599725.1 94991626 4065641 138630..139649 1 NC_008023.1 transcriptional regulator pfoR 139649 sloR 4065641 sloR Streptococcus pyogenes MGAS2096 transcriptional regulator pfoR YP_599725.1 138630 D 370565 CDS YP_599726.1 94991627 4065642 140100..140423 1 NC_008023.1 hypothetical protein 140423 4065642 MGAS2096_Spy0130 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599726.1 140100 D 370565 CDS YP_599727.1 94991628 4065643 140413..142413 1 NC_008023.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I is part of the membrane proton channel.; V-type ATP synthase subunit I 142413 ntpI 4065643 ntpI Streptococcus pyogenes MGAS2096 V-type ATP synthase subunit I YP_599727.1 140413 D 370565 CDS YP_599728.2 162139138 4065644 142415..142894 1 NC_008023.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the K subunit is a nonenzymatic component which binds the dimeric form by interacting with the G and E subunits; V-type ATP synthase subunit K 142894 ntpK 4065644 ntpK Streptococcus pyogenes MGAS2096 V-type ATP synthase subunit K YP_599728.2 142415 D 370565 CDS YP_599729.1 94991630 4065645 142963..143547 1 NC_008023.1 V-type sodium ATP synthase subunit E 143547 ntpE 4065645 ntpE Streptococcus pyogenes MGAS2096 V-type sodium ATP synthase subunit E YP_599729.1 142963 D 370565 CDS YP_599730.1 94991631 4065646 143563..144561 1 NC_008023.1 V-type sodium ATP synthase subunit C 144561 ntpC 4065646 ntpC Streptococcus pyogenes MGAS2096 V-type sodium ATP synthase subunit C YP_599730.1 143563 D 370565 CDS YP_599731.1 94991632 4065647 144558..144878 1 NC_008023.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the F subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit F 144878 ntpF 4065647 ntpF Streptococcus pyogenes MGAS2096 V-type ATP synthase subunit F YP_599731.1 144558 D 370565 CDS YP_599732.1 94991633 4065648 145079..146854 1 NC_008023.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the A subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit A 146854 ntpA 4065648 ntpA Streptococcus pyogenes MGAS2096 V-type ATP synthase subunit A YP_599732.1 145079 D 370565 CDS YP_599733.1 94991634 4065649 146855..148270 1 NC_008023.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the B subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit B 148270 ntpB 4065649 ntpB Streptococcus pyogenes MGAS2096 V-type ATP synthase subunit B YP_599733.1 146855 D 370565 CDS YP_599734.1 94991635 4065650 148294..148941 1 NC_008023.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the D subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit D 148941 ntpD 4065650 ntpD Streptococcus pyogenes MGAS2096 V-type ATP synthase subunit D YP_599734.1 148294 D 370565 CDS YP_599735.1 94991636 4065651 complement(149061..150323) 1 NC_008023.1 tellurite resistance protein 150323 4065651 MGAS2096_Spy0139 Streptococcus pyogenes MGAS2096 tellurite resistance protein YP_599735.1 149061 R 370565 CDS YP_599736.1 94991637 4065652 complement(150336..151214) 1 NC_008023.1 hypothetical protein 151214 4065652 MGAS2096_Spy0140 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599736.1 150336 R 370565 CDS YP_599737.1 94991638 4065653 151652..151936 1 NC_008023.1 adenylosuccinate synthetase 151936 4065653 MGAS2096_Spy0141 Streptococcus pyogenes MGAS2096 adenylosuccinate synthetase YP_599737.1 151652 D 370565 CDS YP_599738.1 94991639 4065654 152061..152945 1 NC_008023.1 adenylosuccinate synthetase 152945 purA 4065654 purA Streptococcus pyogenes MGAS2096 adenylosuccinate synthetase YP_599738.1 152061 D 370565 CDS YP_599739.1 94991640 4065655 153272..154315 1 NC_008023.1 nucleoside-binding protein 154315 4065655 MGAS2096_Spy0143 Streptococcus pyogenes MGAS2096 nucleoside-binding protein YP_599739.1 153272 D 370565 CDS YP_599740.1 94991641 4065656 complement(154341..154454) 1 NC_008023.1 hypothetical protein 154454 4065656 MGAS2096_Spy0144 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599740.1 154341 R 370565 CDS YP_599741.1 94991642 4065657 154473..155027 1 NC_008023.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 155027 nusG 4065657 nusG Streptococcus pyogenes MGAS2096 transcription antitermination protein NusG YP_599741.1 154473 D 370565 CDS YP_599742.1 94991643 4065658 155389..156753 1 NC_008023.1 NAD glycohydrolase 156753 nga 4065658 nga Streptococcus pyogenes MGAS2096 NAD glycohydrolase YP_599742.1 155389 D 370565 CDS YP_599743.1 94991644 4065659 156758..157243 1 NC_008023.1 hypothetical protein 157243 ifs 4065659 ifs Streptococcus pyogenes MGAS2096 hypothetical protein YP_599743.1 156758 D 370565 CDS YP_599744.1 94991645 4065660 157258..158982 1 NC_008023.1 streptolysin O 158982 slo 4065660 slo Streptococcus pyogenes MGAS2096 streptolysin O YP_599744.1 157258 D 370565 CDS YP_599745.1 94991646 4065661 159237..159668 1 NC_008023.1 hypothetical protein 159668 4065661 MGAS2096_Spy0149 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599745.1 159237 D 370565 CDS YP_599746.1 94991647 4065662 complement(160500..160667) 1 NC_008023.1 hypothetical protein 160667 4065662 MGAS2096_Spy0150 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599746.1 160500 R 370565 CDS YP_599747.1 94991648 4065663 complement(160842..161048) 1 NC_008023.1 hypothetical protein 161048 4065663 MGAS2096_Spy0151 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599747.1 160842 R 370565 CDS YP_599748.1 94991649 4065664 161480..162448 1 NC_008023.1 cystathionine beta-lyase 162448 metB 4065664 metB Streptococcus pyogenes MGAS2096 cystathionine beta-lyase YP_599748.1 161480 D 370565 CDS YP_599749.1 94991650 4065665 162527..162763 1 NC_008023.1 cystathionine beta-lyase 162763 4065665 MGAS2096_Spy0153 Streptococcus pyogenes MGAS2096 cystathionine beta-lyase YP_599749.1 162527 D 370565 CDS YP_599750.1 94991651 4065666 162974..165475 1 NC_008023.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 165475 leuS 4065666 leuS Streptococcus pyogenes MGAS2096 leucyl-tRNA synthetase YP_599750.1 162974 D 370565 CDS YP_599751.1 94991652 4065667 165838..166701 1 NC_008023.1 transposase 166701 4065667 MGAS2096_Spy0155 Streptococcus pyogenes MGAS2096 transposase YP_599751.1 165838 D 370565 CDS YP_599752.1 94991653 4065668 166750..168183 1 NC_008023.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 168183 ulaA 4065668 ulaA Streptococcus pyogenes MGAS2096 PTS system ascorbate-specific transporter subunit IIC YP_599752.1 166750 D 370565 CDS YP_599753.1 94991654 4065669 168254..168532 1 NC_008023.1 PTS system 3-keto-L-gulonate specific transporter subunit IIB 168532 4065669 MGAS2096_Spy0157 Streptococcus pyogenes MGAS2096 PTS system 3-keto-L-gulonate specific transporter subunit IIB YP_599753.1 168254 D 370565 CDS YP_599754.1 94991655 4065670 168655..169140 1 NC_008023.1 PTS system 3-keto-L-gulonate specific transporter subunit IIA 169140 4065670 MGAS2096_Spy0158 Streptococcus pyogenes MGAS2096 PTS system 3-keto-L-gulonate specific transporter subunit IIA YP_599754.1 168655 D 370565 CDS YP_599755.1 94991656 4065671 169231..169893 1 NC_008023.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 169893 ulaD 4065671 ulaD Streptococcus pyogenes MGAS2096 3-keto-L-gulonate-6-phosphate decarboxylase YP_599755.1 169231 D 370565 CDS YP_599756.1 94991657 4065672 169856..170761 1 NC_008023.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; putative L-xylulose 5-phosphate 3-epimerase 170761 4065672 MGAS2096_Spy0160 Streptococcus pyogenes MGAS2096 putative L-xylulose 5-phosphate 3-epimerase YP_599756.1 169856 D 370565 CDS YP_599757.1 94991658 4065790 170739..171467 1 NC_008023.1 catalyzes the formation of D-xylulose 5-phosphate from L-ribulose 5-phosphate in the L-arabinose and L-ascorbate degradation pathways; L-ribulose-5-phosphate 4-epimerase 171467 araD 4065790 araD Streptococcus pyogenes MGAS2096 L-ribulose-5-phosphate 4-epimerase YP_599757.1 170739 D 370565 CDS YP_599758.1 94991659 4065791 171525..171671 1 NC_008023.1 hypothetical protein 171671 4065791 MGAS2096_Spy0162 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599758.1 171525 D 370565 CDS YP_599759.1 94991660 4065792 171792..173438 1 NC_008023.1 BigG family transcription antiterminator 173438 4065792 MGAS2096_Spy0163 Streptococcus pyogenes MGAS2096 BigG family transcription antiterminator YP_599759.1 171792 D 370565 CDS YP_599760.1 94991661 4065793 173691..174782 1 NC_008023.1 putative L-ascorbate 6-phosphate lactonase 174782 4065793 MGAS2096_Spy0164 Streptococcus pyogenes MGAS2096 putative L-ascorbate 6-phosphate lactonase YP_599760.1 173691 D 370565 CDS YP_599761.1 94991662 4065794 175270..175491 1 NC_008023.1 glycine betaine transport ATP-binding protein 175491 4065794 MGAS2096_Spy0165 Streptococcus pyogenes MGAS2096 glycine betaine transport ATP-binding protein YP_599761.1 175270 D 370565 CDS YP_599762.1 94991663 4065795 175485..175733 1 NC_008023.1 glycine betaine transport ATP-binding protein 175733 4065795 MGAS2096_Spy0166 Streptococcus pyogenes MGAS2096 glycine betaine transport ATP-binding protein YP_599762.1 175485 D 370565 CDS YP_599763.1 94991664 4065796 175637..176464 1 NC_008023.1 glycine betaine transport ATP-binding protein 176464 opuAA 4065796 opuAA Streptococcus pyogenes MGAS2096 glycine betaine transport ATP-binding protein YP_599763.1 175637 D 370565 CDS YP_599764.1 94991665 4065797 176480..177499 1 NC_008023.1 glycine betaine-binding protein / glycine betaine transport system permease 177499 opuABC 4065797 opuABC Streptococcus pyogenes MGAS2096 glycine betaine-binding protein / glycine betaine transport system permease YP_599764.1 176480 D 370565 CDS YP_599765.1 94991666 4065798 177463..178206 1 NC_008023.1 glycine betaine-binding protein / glycine betaine transport system permease 178206 4065798 MGAS2096_Spy0169 Streptococcus pyogenes MGAS2096 glycine betaine-binding protein / glycine betaine transport system permease YP_599765.1 177463 D 370565 CDS YP_599766.1 94991667 4065799 178558..180978 1 NC_008023.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 180978 polA 4065799 polA Streptococcus pyogenes MGAS2096 DNA polymerase I YP_599766.1 178558 D 370565 CDS YP_599767.1 94991668 4065800 181165..181620 1 NC_008023.1 CoA binding protein 181620 4065800 MGAS2096_Spy0171 Streptococcus pyogenes MGAS2096 CoA binding protein YP_599767.1 181165 D 370565 CDS YP_599768.1 94991669 4065801 181672..182139 1 NC_008023.1 ferric uptake regulation protein 182139 perR 4065801 perR Streptococcus pyogenes MGAS2096 ferric uptake regulation protein YP_599768.1 181672 D 370565 CDS YP_599769.1 94991670 4065802 182296..182595 1 NC_008023.1 transcriptional regulatory protein 182595 vlg 4065802 vlg Streptococcus pyogenes MGAS2096 transcriptional regulatory protein YP_599769.1 182296 D 370565 CDS YP_599770.1 94991671 4065803 182817..184151 1 NC_008023.1 Co-activator of prophage gene expression IbrA 184151 4065803 MGAS2096_Spy0174 Streptococcus pyogenes MGAS2096 Co-activator of prophage gene expression IbrA YP_599770.1 182817 D 370565 CDS YP_599771.1 94991672 4065804 184144..184674 1 NC_008023.1 Co-activator of prophage gene expression IbrB 184674 4065804 MGAS2096_Spy0175 Streptococcus pyogenes MGAS2096 Co-activator of prophage gene expression IbrB YP_599771.1 184144 D 370565 CDS YP_599772.1 94991673 4065805 complement(184721..184963) 1 NC_008023.1 transposase 184963 4065805 MGAS2096_Spy0176 Streptococcus pyogenes MGAS2096 transposase YP_599772.1 184721 R 370565 CDS YP_599773.1 94991674 4065806 complement(185003..185218) 1 NC_008023.1 transposase 185218 4065806 MGAS2096_Spy0177 Streptococcus pyogenes MGAS2096 transposase YP_599773.1 185003 R 370565 CDS YP_599774.1 94991675 4065807 complement(185215..185826) 1 NC_008023.1 transposase 185826 4065807 MGAS2096_Spy0178 Streptococcus pyogenes MGAS2096 transposase YP_599774.1 185215 R 370565 CDS YP_599775.1 94991676 4065808 complement(185859..186074) 1 NC_008023.1 transposase 186074 4065808 MGAS2096_Spy0179 Streptococcus pyogenes MGAS2096 transposase YP_599775.1 185859 R 370565 CDS YP_599776.1 94991677 4066422 complement(186230..187540) 1 NC_008023.1 transporter 187540 4066422 MGAS2096_Spy0180 Streptococcus pyogenes MGAS2096 transporter YP_599776.1 186230 R 370565 CDS YP_599777.1 94991678 4066423 187737..188636 1 NC_008023.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase 188636 nadC 4066423 nadC Streptococcus pyogenes MGAS2096 nicotinate-nucleotide pyrophosphorylase YP_599777.1 187737 D 370565 CDS YP_599778.1 94991679 4066424 complement(188936..189742) 1 NC_008023.1 transposase 189742 4066424 MGAS2096_Spy0182 Streptococcus pyogenes MGAS2096 transposase YP_599778.1 188936 R 370565 CDS YP_599779.1 94991680 4066425 complement(189763..190296) 1 NC_008023.1 transposase 190296 4066425 MGAS2096_Spy0183 Streptococcus pyogenes MGAS2096 transposase YP_599779.1 189763 R 370565 CDS YP_599780.1 94991681 4066426 complement(190364..191227) 1 NC_008023.1 integral membrane protein 191227 4066426 MGAS2096_Spy0184 Streptococcus pyogenes MGAS2096 integral membrane protein YP_599780.1 190364 R 370565 CDS YP_599781.1 94991682 4066427 191264..191449 1 NC_008023.1 hypothetical protein 191449 4066427 MGAS2096_Spy0185 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599781.1 191264 D 370565 CDS YP_599782.1 94991683 4066428 191446..192588 1 NC_008023.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 192588 tgt 4066428 tgt Streptococcus pyogenes MGAS2096 queuine tRNA-ribosyltransferase YP_599782.1 191446 D 370565 CDS YP_599783.1 94991684 4066429 192806..193117 1 NC_008023.1 Zinc finger protein 193117 4066429 MGAS2096_Spy0187 Streptococcus pyogenes MGAS2096 Zinc finger protein YP_599783.1 192806 D 370565 CDS YP_599784.1 94991685 4066430 193121..193660 1 NC_008023.1 BioY protein 193660 4066430 MGAS2096_Spy0188 Streptococcus pyogenes MGAS2096 BioY protein YP_599784.1 193121 D 370565 CDS YP_599785.1 94991686 4066431 193819..194961 1 NC_008023.1 transposase 194961 4066431 MGAS2096_Spy0189 Streptococcus pyogenes MGAS2096 transposase YP_599785.1 193819 D 370565 CDS YP_599786.1 94991687 4066432 194945..195076 1 NC_008023.1 hypothetical protein 195076 4066432 MGAS2096_Spy0190 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599786.1 194945 D 370565 CDS YP_599787.1 94991688 4066433 195126..195905 1 NC_008023.1 metal-dependent hydrolase 195905 4066433 MGAS2096_Spy0191 Streptococcus pyogenes MGAS2096 metal-dependent hydrolase YP_599787.1 195126 D 370565 CDS YP_599788.1 94991689 4066434 195881..196420 1 NC_008023.1 tRNA-specific adenosine deaminase 196420 4066434 MGAS2096_Spy0192 Streptococcus pyogenes MGAS2096 tRNA-specific adenosine deaminase YP_599788.1 195881 D 370565 CDS YP_599789.1 94991690 4066435 complement(197034..198266) 1 NC_008023.1 S-layer protein / peptidoglycan endo-beta-N-acetylglucosaminidase 198266 4066435 MGAS2096_Spy0193 Streptococcus pyogenes MGAS2096 S-layer protein / peptidoglycan endo-beta-N-acetylglucosaminidase YP_599789.1 197034 R 370565 CDS YP_599790.1 94991691 4066436 198308..198415 1 NC_008023.1 putative cytoplasmic protein 198415 4066436 MGAS2096_Spy0194 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_599790.1 198308 D 370565 CDS YP_599791.1 94991692 4066437 198666..199370 1 NC_008023.1 enterotoxin 199370 speG 4066437 speG Streptococcus pyogenes MGAS2096 enterotoxin YP_599791.1 198666 D 370565 CDS YP_599792.1 94991693 4066438 199458..199577 1 NC_008023.1 hypothetical protein 199577 4066438 MGAS2096_Spy0196 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599792.1 199458 D 370565 CDS YP_599793.1 94991694 4066439 199613..199732 1 NC_008023.1 putative cytoplasmic protein 199732 4066439 MGAS2096_Spy0197 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_599793.1 199613 D 370565 CDS YP_599794.1 94991695 4066440 199829..201178 1 NC_008023.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 201178 pgi 4066440 pgi Streptococcus pyogenes MGAS2096 glucose-6-phosphate isomerase YP_599794.1 199829 D 370565 CDS YP_599795.1 94991696 4066441 complement(201527..203035) 1 NC_008023.1 transcriptional regulator 203035 4066441 MGAS2096_Spy0199 Streptococcus pyogenes MGAS2096 transcriptional regulator YP_599795.1 201527 R 370565 CDS YP_599796.1 94991697 4064943 203581..204384 1 NC_008023.1 transposase 204384 4064943 MGAS2096_Spy0200 Streptococcus pyogenes MGAS2096 transposase YP_599796.1 203581 D 370565 CDS YP_599797.1 94991698 4064944 204381..204722 1 NC_008023.1 transposase 204722 4064944 MGAS2096_Spy0201 Streptococcus pyogenes MGAS2096 transposase YP_599797.1 204381 D 370565 CDS YP_599798.1 94991699 4064945 204706..204831 1 NC_008023.1 hypothetical protein 204831 4064945 MGAS2096_Spy0202 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599798.1 204706 D 370565 CDS YP_599799.1 94991700 4064946 204912..205019 1 NC_008023.1 putative cytoplasmic protein 205019 4064946 MGAS2096_Spy0203 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_599799.1 204912 D 370565 CDS YP_599800.1 94991701 4064947 205047..205718 1 NC_008023.1 Rhomboid family; integral membrane protein 205718 4064947 MGAS2096_Spy0204 Streptococcus pyogenes MGAS2096 integral membrane protein YP_599800.1 205047 D 370565 CDS YP_599801.1 94991702 4064948 complement(205817..206722) 1 NC_008023.1 UTP--glucose-1-phosphate uridylyltransferase 206722 hasC2 4064948 hasC2 Streptococcus pyogenes MGAS2096 UTP--glucose-1-phosphate uridylyltransferase YP_599801.1 205817 R 370565 CDS YP_599802.1 94991703 4064949 complement(206749..207765) 1 NC_008023.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 207765 gpsA 4064949 gpsA Streptococcus pyogenes MGAS2096 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_599802.1 206749 R 370565 CDS YP_599803.1 94991704 4064950 208063..208512 1 NC_008023.1 MarR family transcriptional regulator 208512 4064950 MGAS2096_Spy0207 Streptococcus pyogenes MGAS2096 MarR family transcriptional regulator YP_599803.1 208063 D 370565 CDS YP_599804.1 94991705 4064951 208505..210211 1 NC_008023.1 multidrug ABC transporter permease/ATP-binding protein 210211 4064951 MGAS2096_Spy0208 Streptococcus pyogenes MGAS2096 multidrug ABC transporter permease/ATP-binding protein YP_599804.1 208505 D 370565 CDS YP_599805.1 94991706 4064952 210211..211998 1 NC_008023.1 multidrug/protein/lipid ABC transporter family ATP-binding and permease 211998 4064952 MGAS2096_Spy0209 Streptococcus pyogenes MGAS2096 multidrug/protein/lipid ABC transporter family ATP-binding and permease YP_599805.1 210211 D 370565 CDS YP_599806.1 94991707 4064953 212116..212883 1 NC_008023.1 putative cytoplasmic protein 212883 4064953 MGAS2096_Spy0210 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_599806.1 212116 D 370565 CDS YP_599807.1 94991708 4064954 212993..213283 1 NC_008023.1 deoxyuridine 5'-triphosphate nucleotidohydrolase 213283 4064954 MGAS2096_Spy0211 Streptococcus pyogenes MGAS2096 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_599807.1 212993 D 370565 CDS YP_599808.1 94991709 4064955 213299..213439 1 NC_008023.1 deoxyuridine 5'-triphosphate nucleotidohydrolase 213439 4064955 MGAS2096_Spy0212 Streptococcus pyogenes MGAS2096 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_599808.1 213299 D 370565 CDS YP_599809.1 94991710 4064956 213520..214881 1 NC_008023.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 214881 radA 4064956 radA Streptococcus pyogenes MGAS2096 DNA repair protein RadA YP_599809.1 213520 D 370565 CDS YP_599810.1 94991711 4064957 215067..215474 1 NC_008023.1 carbonic anhydrase 215474 4064957 MGAS2096_Spy0214 Streptococcus pyogenes MGAS2096 carbonic anhydrase YP_599810.1 215067 D 370565 CDS YP_599811.1 94991712 4064958 215407..215568 1 NC_008023.1 carbonic anhydrase 215568 4064958 MGAS2096_Spy0215 Streptococcus pyogenes MGAS2096 carbonic anhydrase YP_599811.1 215407 D 370565 CDS YP_599812.1 94991713 4064959 215663..216409 1 NC_008023.1 hypothetical protein 216409 4064959 MGAS2096_Spy0216 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599812.1 215663 D 370565 CDS YP_599813.1 94991714 4064960 216607..217290 1 NC_008023.1 glutamyl-tRNA synthetase 217290 4064960 MGAS2096_Spy0217 Streptococcus pyogenes MGAS2096 glutamyl-tRNA synthetase YP_599813.1 216607 D 370565 CDS YP_599814.1 94991715 4064961 217287..218051 1 NC_008023.1 glutamyl-tRNA synthetase 218051 gltX 4064961 gltX Streptococcus pyogenes MGAS2096 glutamyl-tRNA synthetase YP_599814.1 217287 D 370565 CDS YP_599815.1 94991716 4066402 218447..219793 1 NC_008023.1 sensory transduction protein kinase FasB 219793 fasB 4066402 fasB Streptococcus pyogenes MGAS2096 sensory transduction protein kinase FasB YP_599815.1 218447 D 370565 CDS YP_599816.1 94991717 4066403 219790..221073 1 NC_008023.1 sensory transduction protein kinase FasC 221073 fasC 4066403 fasC Streptococcus pyogenes MGAS2096 sensory transduction protein kinase FasC YP_599816.1 219790 D 370565 CDS YP_599817.1 94991718 4066404 221077..221817 1 NC_008023.1 response regulator FasA 221817 fasA 4066404 fasA Streptococcus pyogenes MGAS2096 response regulator FasA YP_599817.1 221077 D 370565 CDS YP_599818.1 94991719 4066405 222357..222716 1 NC_008023.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 222716 rnpA 4066405 rnpA Streptococcus pyogenes MGAS2096 ribonuclease P YP_599818.1 222357 D 370565 CDS YP_599819.1 94991720 4066406 222682..223509 1 NC_008023.1 60 kDa inner membrane protein YIDC 223509 4066406 MGAS2096_Spy0223 Streptococcus pyogenes MGAS2096 60 kDa inner membrane protein YIDC YP_599819.1 222682 D 370565 CDS YP_599820.1 94991721 4066407 223521..223790 1 NC_008023.1 Jag protein 223790 4066407 MGAS2096_Spy0224 Streptococcus pyogenes MGAS2096 Jag protein YP_599820.1 223521 D 370565 CDS YP_599821.1 94991722 4066408 223834..224259 1 NC_008023.1 Jag protein 224259 4066408 MGAS2096_Spy0225 Streptococcus pyogenes MGAS2096 Jag protein YP_599821.1 223834 D 370565 CDS YP_599822.1 94991723 4066409 224228..224437 1 NC_008023.1 Jag protein 224437 4066409 MGAS2096_Spy0226 Streptococcus pyogenes MGAS2096 Jag protein YP_599822.1 224228 D 370565 CDS YP_599823.1 94991724 4066410 224520..224642 1 NC_008023.1 hypothetical protein 224642 4066410 MGAS2096_Spy0227 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599823.1 224520 D 370565 CDS YP_599824.1 94991725 4066411 224750..224884 1 NC_008023.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 224884 rpmH 4066411 rpmH Streptococcus pyogenes MGAS2096 50S ribosomal protein L34 YP_599824.1 224750 D 370565 CDS YP_599825.1 94991726 4066412 225158..225862 1 NC_008023.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 225862 4066412 MGAS2096_Spy0229 Streptococcus pyogenes MGAS2096 N-acetylmannosamine-6-phosphate 2-epimerase YP_599825.1 225158 D 370565 CDS YP_599826.1 94991727 4066413 225911..226147 1 NC_008023.1 N-acetylneuraminate-binding protein 226147 4066413 MGAS2096_Spy0230 Streptococcus pyogenes MGAS2096 N-acetylneuraminate-binding protein YP_599826.1 225911 D 370565 CDS YP_599827.1 94991728 4066414 226150..227229 1 NC_008023.1 N-acetylneuraminate-binding protein 227229 4066414 MGAS2096_Spy0231 Streptococcus pyogenes MGAS2096 N-acetylneuraminate-binding protein YP_599827.1 226150 D 370565 CDS YP_599828.1 94991729 4066415 227333..228220 1 NC_008023.1 N-acetylneuraminate transport system permease 228220 4066415 MGAS2096_Spy0232 Streptococcus pyogenes MGAS2096 N-acetylneuraminate transport system permease YP_599828.1 227333 D 370565 CDS YP_599829.1 94991730 4066416 228233..229063 1 NC_008023.1 N-acetylneuraminate transport system permease 229063 4066416 MGAS2096_Spy0233 Streptococcus pyogenes MGAS2096 N-acetylneuraminate transport system permease YP_599829.1 228233 D 370565 CDS YP_599830.1 94991731 4066417 229220..229882 1 NC_008023.1 hypothetical protein 229882 4066417 MGAS2096_Spy0234 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599830.1 229220 D 370565 CDS YP_599831.1 94991732 4066418 229894..230808 1 NC_008023.1 N-acetylneuraminate lyase 230808 nanH 4066418 nanH Streptococcus pyogenes MGAS2096 N-acetylneuraminate lyase YP_599831.1 229894 D 370565 CDS YP_599832.1 94991733 4066419 230830..231768 1 NC_008023.1 N-acetylmannosamine kinase / transcriptional regulator 231768 4066419 MGAS2096_Spy0236 Streptococcus pyogenes MGAS2096 N-acetylmannosamine kinase / transcriptional regulator YP_599832.1 230830 D 370565 CDS YP_599833.1 94991734 4066420 complement(231879..232721) 1 NC_008023.1 RpiR family transcriptional regulator 232721 4066420 MGAS2096_Spy0237 Streptococcus pyogenes MGAS2096 RpiR family transcriptional regulator YP_599833.1 231879 R 370565 CDS YP_599834.1 94991735 4066421 232898..233785 1 NC_008023.1 TatD family deoxyribonuclease 233785 tatD 4066421 tatD Streptococcus pyogenes MGAS2096 TatD family deoxyribonuclease YP_599834.1 232898 D 370565 CDS YP_599835.1 94991736 4064864 233736..234347 1 NC_008023.1 ribonuclease M5 234347 4064864 MGAS2096_Spy0239 Streptococcus pyogenes MGAS2096 ribonuclease M5 YP_599835.1 233736 D 370565 CDS YP_599836.1 94991737 4064865 234437..235333 1 NC_008023.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 235333 ksgA 4064865 ksgA Streptococcus pyogenes MGAS2096 dimethyladenosine transferase YP_599836.1 234437 D 370565 CDS YP_599837.1 94991738 4064866 235757..236629 1 NC_008023.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 236629 4064866 MGAS2096_Spy0241 Streptococcus pyogenes MGAS2096 ribosome-associated GTPase YP_599837.1 235757 D 370565 CDS YP_599838.1 94991739 4064867 236639..237301 1 NC_008023.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 237301 rpe 4064867 rpe Streptococcus pyogenes MGAS2096 ribulose-phosphate 3-epimerase YP_599838.1 236639 D 370565 CDS YP_599839.1 94991740 4064868 237294..237926 1 NC_008023.1 thiamin pyrophosphokinase 237926 4064868 MGAS2096_Spy0243 Streptococcus pyogenes MGAS2096 thiamin pyrophosphokinase YP_599839.1 237294 D 370565 CDS YP_599840.1 94991741 4064869 237928..239199 1 NC_008023.1 RmuC family protein 239199 4064869 MGAS2096_Spy0244 Streptococcus pyogenes MGAS2096 RmuC family protein YP_599840.1 237928 D 370565 CDS YP_599841.1 94991742 4064870 239189..240127 1 NC_008023.1 CMP-binding factor 240127 cbf 4064870 cbf Streptococcus pyogenes MGAS2096 CMP-binding factor YP_599841.1 239189 D 370565 CDS YP_599842.1 94991743 4064871 240394..241233 1 NC_008023.1 pur operon repressor 241233 purR 4064871 purR Streptococcus pyogenes MGAS2096 pur operon repressor YP_599842.1 240394 D 370565 CDS YP_599843.1 94991744 4064872 241206..243845 1 NC_008023.1 surface exclusion protein 243845 prgA 4064872 prgA Streptococcus pyogenes MGAS2096 surface exclusion protein YP_599843.1 241206 D 370565 CDS YP_599844.1 94991745 4064873 244053..244496 1 NC_008023.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 244496 rpsL 4064873 rpsL Streptococcus pyogenes MGAS2096 30S ribosomal protein S12 YP_599844.1 244053 D 370565 CDS YP_599845.1 94991746 4064874 244486..244956 1 NC_008023.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 244956 rpsG 4064874 rpsG Streptococcus pyogenes MGAS2096 30S ribosomal protein S7 YP_599845.1 244486 D 370565 CDS YP_599846.1 94991747 4064875 245323..245631 1 NC_008023.1 protein translation elongation factor G (EF-G) 245631 4064875 MGAS2096_Spy0250 Streptococcus pyogenes MGAS2096 protein translation elongation factor G (EF-G) YP_599846.1 245323 D 370565 CDS YP_599847.1 94991748 4064876 245577..247400 1 NC_008023.1 protein translation elongation factor G (EF-G) 247400 fus 4064876 fus Streptococcus pyogenes MGAS2096 protein translation elongation factor G (EF-G) YP_599847.1 245577 D 370565 CDS YP_599848.1 94991749 4064877 247721..248758 1 NC_008023.1 glyceraldehyde-3-phosphate dehydrogenase 248758 plr 4064877 plr Streptococcus pyogenes MGAS2096 glyceraldehyde-3-phosphate dehydrogenase YP_599848.1 247721 D 370565 CDS YP_599849.1 94991750 4064878 complement(249244..250053) 1 NC_008023.1 amino acid ABC transporter ATP-binding protein 250053 4064878 MGAS2096_Spy0253 Streptococcus pyogenes MGAS2096 amino acid ABC transporter ATP-binding protein YP_599849.1 249244 R 370565 CDS YP_599850.1 94991751 4064879 complement(249977..251140) 1 NC_008023.1 amino acid ABC transporter permease 251140 4064879 MGAS2096_Spy0254 Streptococcus pyogenes MGAS2096 amino acid ABC transporter permease YP_599850.1 249977 R 370565 CDS YP_599851.1 94991752 4064880 complement(251100..251564) 1 NC_008023.1 amino acid ABC transporter permease 251564 4064880 MGAS2096_Spy0255 Streptococcus pyogenes MGAS2096 amino acid ABC transporter permease YP_599851.1 251100 R 370565 CDS YP_599852.1 94991753 4064881 251744..253669 1 NC_008023.1 hypothetical protein 253669 4064881 MGAS2096_Spy0256 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599852.1 251744 D 370565 CDS YP_599853.1 94991754 4064882 253735..254574 1 NC_008023.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 254574 bacA 4064882 bacA Streptococcus pyogenes MGAS2096 undecaprenyl pyrophosphate phosphatase YP_599853.1 253735 D 370565 CDS YP_599854.1 94991755 4064634 254714..255481 1 NC_008023.1 enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence; adaptor protein 255481 mecA 4064634 mecA Streptococcus pyogenes MGAS2096 adaptor protein YP_599854.1 254714 D 370565 CDS YP_599855.1 94991756 4064635 255488..256657 1 NC_008023.1 undecaprenyl-phosphate alpha-N-acetylglucosaminephosphotransferase 256657 4064635 MGAS2096_Spy0259 Streptococcus pyogenes MGAS2096 undecaprenyl-phosphate alpha-N-acetylglucosaminephosphotransferase YP_599855.1 255488 D 370565 CDS YP_599856.1 94991757 4064636 256627..256752 1 NC_008023.1 putative cytoplasmic protein 256752 rgpG 4064636 rgpG Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_599856.1 256627 D 370565 CDS YP_599857.1 94991758 4064637 256779..257549 1 NC_008023.1 ATP-dependent transporter sufC 257549 4064637 MGAS2096_Spy0261 Streptococcus pyogenes MGAS2096 ATP-dependent transporter sufC YP_599857.1 256779 D 370565 CDS YP_599858.1 94991759 4064638 257644..258906 1 NC_008023.1 SufD protein 258906 4064638 MGAS2096_Spy0262 Streptococcus pyogenes MGAS2096 SufD protein YP_599858.1 257644 D 370565 CDS YP_599859.1 94991760 4064639 258937..260163 1 NC_008023.1 bifunctional; cysteine desulfurase / selenocysteine lyase 260163 nifS3 4064639 nifS3 Streptococcus pyogenes MGAS2096 cysteine desulfurase / selenocysteine lyase YP_599859.1 258937 D 370565 CDS YP_599860.1 94991761 4064640 260150..260629 1 NC_008023.1 IscU protein 260629 nifU 4064640 nifU Streptococcus pyogenes MGAS2096 IscU protein YP_599860.1 260150 D 370565 CDS YP_599861.1 94991762 4064641 260622..262040 1 NC_008023.1 ABC transporter-associated protein sufB 262040 4064641 MGAS2096_Spy0265 Streptococcus pyogenes MGAS2096 ABC transporter-associated protein sufB YP_599861.1 260622 D 370565 CDS YP_599862.1 94991763 4064642 complement(262192..262692) 1 NC_008023.1 D-alanyl-D-alanine carboxypeptidase 262692 4064642 MGAS2096_Spy0266 Streptococcus pyogenes MGAS2096 D-alanyl-D-alanine carboxypeptidase YP_599862.1 262192 R 370565 CDS YP_599863.1 94991764 4064643 complement(262677..263372) 1 NC_008023.1 D-alanyl-D-alanine carboxypeptidase 263372 4064643 MGAS2096_Spy0267 Streptococcus pyogenes MGAS2096 D-alanyl-D-alanine carboxypeptidase YP_599863.1 262677 R 370565 CDS YP_599864.1 94991765 4064644 complement(263541..263921) 1 NC_008023.1 D-alanyl-D-alanine carboxypeptidase 263921 4064644 MGAS2096_Spy0268 Streptococcus pyogenes MGAS2096 D-alanyl-D-alanine carboxypeptidase YP_599864.1 263541 R 370565 CDS YP_599865.1 94991766 4064645 complement(263945..264772) 1 NC_008023.1 D-alanyl-D-alanine carboxypeptidase 264772 dacA2 4064645 dacA2 Streptococcus pyogenes MGAS2096 D-alanyl-D-alanine carboxypeptidase YP_599865.1 263945 R 370565 CDS YP_599866.1 94991767 4064646 265094..267073 1 NC_008023.1 oligopeptide-binding protein oppA 267073 oppA 4064646 oppA Streptococcus pyogenes MGAS2096 oligopeptide-binding protein oppA YP_599866.1 265094 D 370565 CDS YP_599867.1 94991768 4064647 267126..268640 1 NC_008023.1 oligopeptide transport system permease oppB 268640 oppB 4064647 oppB Streptococcus pyogenes MGAS2096 oligopeptide transport system permease oppB YP_599867.1 267126 D 370565 CDS YP_599868.1 94991769 4064648 268640..269566 1 NC_008023.1 oligopeptide transport system permease oppC 269566 oppC 4064648 oppC Streptococcus pyogenes MGAS2096 oligopeptide transport system permease oppC YP_599868.1 268640 D 370565 CDS YP_599869.1 94991770 4064649 269575..270645 1 NC_008023.1 oligopeptide transport ATP-binding protein oppD 270645 oppD 4064649 oppD Streptococcus pyogenes MGAS2096 oligopeptide transport ATP-binding protein oppD YP_599869.1 269575 D 370565 CDS YP_599870.1 94991771 4064650 270638..271561 1 NC_008023.1 oligopeptide transport ATP-binding protein oppF 271561 oppF 4064650 oppF Streptococcus pyogenes MGAS2096 oligopeptide transport ATP-binding protein oppF YP_599870.1 270638 D 370565 CDS YP_599871.1 94991772 4064651 complement(271710..271949) 1 NC_008023.1 transposase 271949 4064651 MGAS2096_Spy0275 Streptococcus pyogenes MGAS2096 transposase YP_599871.1 271710 R 370565 CDS YP_599872.1 94991773 4064652 complement(272324..272458) 1 NC_008023.1 hypothetical protein 272458 4064652 MGAS2096_Spy0276 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599872.1 272324 R 370565 CDS YP_599873.1 94991774 4066382 277946..278431 1 NC_008023.1 competence-specific sigma factor ComX 278431 comX2 4066382 comX2 Streptococcus pyogenes MGAS2096 competence-specific sigma factor ComX YP_599873.1 277946 D 370565 CDS YP_599874.1 94991775 4066383 278933..279517 1 NC_008023.1 putative lipase 279517 4066383 MGAS2096_Spy0278 Streptococcus pyogenes MGAS2096 putative lipase YP_599874.1 278933 D 370565 CDS YP_599875.1 94991776 4066384 279517..280635 1 NC_008023.1 in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis; GTP-binding protein YqeH 280635 4066384 MGAS2096_Spy0279 Streptococcus pyogenes MGAS2096 GTP-binding protein YqeH YP_599875.1 279517 D 370565 CDS YP_599876.1 94991777 4066385 280660..280968 1 NC_008023.1 RNA-binding protein 280968 4066385 MGAS2096_Spy0280 Streptococcus pyogenes MGAS2096 RNA-binding protein YP_599876.1 280660 D 370565 CDS YP_599877.1 94991778 4066386 281037..281669 1 NC_008023.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 281669 nadD 4066386 nadD Streptococcus pyogenes MGAS2096 nicotinic acid mononucleotide adenylyltransferase YP_599877.1 281037 D 370565 CDS YP_599878.1 94991779 4066387 281666..282259 1 NC_008023.1 HAD superfamily; hydrolase 282259 4066387 MGAS2096_Spy0282 Streptococcus pyogenes MGAS2096 hydrolase YP_599878.1 281666 D 370565 CDS YP_599879.1 94991780 4066388 282235..282636 1 NC_008023.1 iojap superfamily protein 282636 4066388 MGAS2096_Spy0283 Streptococcus pyogenes MGAS2096 iojap superfamily protein YP_599879.1 282235 D 370565 CDS YP_599880.1 94991781 4066389 282636..283427 1 NC_008023.1 methyltransferase 283427 4066389 MGAS2096_Spy0284 Streptococcus pyogenes MGAS2096 methyltransferase YP_599880.1 282636 D 370565 CDS YP_599881.1 94991782 4066390 283649..284755 1 NC_008023.1 hypothetical protein 284755 4066390 MGAS2096_Spy0285 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599881.1 283649 D 370565 CDS YP_599882.1 94991783 4066391 285107..285247 1 NC_008023.1 hypothetical protein 285247 4066391 MGAS2096_Spy0286 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599882.1 285107 D 370565 CDS YP_599883.1 94991784 4064732 285237..285953 1 NC_008023.1 hypothetical protein 285953 4064732 MGAS2096_Spy0287 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599883.1 285237 D 370565 CDS YP_599884.1 94991785 4064733 286156..286938 1 NC_008023.1 ABC transporter substrate-binding protein 286938 4064733 MGAS2096_Spy0288 Streptococcus pyogenes MGAS2096 ABC transporter substrate-binding protein YP_599884.1 286156 D 370565 CDS YP_599885.1 94991786 4064734 287327..288172 1 NC_008023.1 ABC transporter substrate-binding protein 288172 4064734 MGAS2096_Spy0289 Streptococcus pyogenes MGAS2096 ABC transporter substrate-binding protein YP_599885.1 287327 D 370565 CDS YP_599886.1 94991787 4064735 288427..289491 1 NC_008023.1 ABC transporter ATP-binding protein 289491 4064735 MGAS2096_Spy0290 Streptococcus pyogenes MGAS2096 ABC transporter ATP-binding protein YP_599886.1 288427 D 370565 CDS YP_599887.1 94991788 4064736 289492..290184 1 NC_008023.1 ABC transporter permease 290184 4064736 MGAS2096_Spy0291 Streptococcus pyogenes MGAS2096 ABC transporter permease YP_599887.1 289492 D 370565 CDS YP_599888.1 94991789 4064737 291845..293059 1 NC_008023.1 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 293059 4064737 MGAS2096_Spy0292 Streptococcus pyogenes MGAS2096 serine/threonine transporter SstT YP_599888.1 291845 D 370565 CDS YP_599889.1 94991790 4064738 complement(293114..293788) 1 NC_008023.1 potassium uptake protein ktrA 293788 4064738 MGAS2096_Spy0293 Streptococcus pyogenes MGAS2096 potassium uptake protein ktrA YP_599889.1 293114 R 370565 CDS YP_599890.1 94991791 4064739 complement(293798..295189) 1 NC_008023.1 potassium uptake protein ktrB 295189 4064739 MGAS2096_Spy0294 Streptococcus pyogenes MGAS2096 potassium uptake protein ktrB YP_599890.1 293798 R 370565 CDS YP_599891.1 94991792 4064740 complement(295259..295972) 1 NC_008023.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 295972 gidB 4064740 gidB Streptococcus pyogenes MGAS2096 16S rRNA methyltransferase GidB YP_599891.1 295259 R 370565 CDS YP_599892.1 94991793 4064741 296122..296679 1 NC_008023.1 LemA protein 296679 lemA 4064741 lemA Streptococcus pyogenes MGAS2096 LemA protein YP_599892.1 296122 D 370565 CDS YP_599893.1 94991794 4064742 296726..297157 1 NC_008023.1 heat shock protein HtpX 297157 4064742 MGAS2096_Spy0297 Streptococcus pyogenes MGAS2096 heat shock protein HtpX YP_599893.1 296726 D 370565 CDS YP_599894.1 94991795 4064743 297209..297622 1 NC_008023.1 heat shock protein HtpX 297622 4064743 MGAS2096_Spy0298 Streptococcus pyogenes MGAS2096 heat shock protein HtpX YP_599894.1 297209 D 370565 CDS YP_599895.1 94991796 4064744 297853..298389 1 NC_008023.1 putative cytoplasmic protein 298389 4064744 MGAS2096_Spy0299 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_599895.1 297853 D 370565 CDS YP_599896.1 94991797 4064745 298655..299341 1 NC_008023.1 response regulator CsrR 299341 covR 4064745 covR Streptococcus pyogenes MGAS2096 response regulator CsrR YP_599896.1 298655 D 370565 CDS YP_599897.1 94991798 4064746 299347..300849 1 NC_008023.1 transmembrane histidine kinase CsrS 300849 covS 4064746 covS Streptococcus pyogenes MGAS2096 transmembrane histidine kinase CsrS YP_599897.1 299347 D 370565 CDS YP_599898.1 94991799 4064747 301064..301558 1 NC_008023.1 transcriptional regulator NrdR 301558 nrdR 4064747 nrdR Streptococcus pyogenes MGAS2096 transcriptional regulator NrdR YP_599898.1 301064 D 370565 CDS YP_599899.1 94991800 4064748 301542..302717 1 NC_008023.1 replicative DNA helicase 302717 dnaB 4064748 dnaB Streptococcus pyogenes MGAS2096 replicative DNA helicase YP_599899.1 301542 D 370565 CDS YP_599900.1 94991801 4064749 302718..303620 1 NC_008023.1 Primosomal protein that may act to load helicase DnaC during DNA replication; primosomal protein DnaI 303620 dnaI 4064749 dnaI Streptococcus pyogenes MGAS2096 primosomal protein DnaI YP_599900.1 302718 D 370565 CDS YP_599901.1 94991802 4064750 303683..304993 1 NC_008023.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 304993 engA 4064750 engA Streptococcus pyogenes MGAS2096 GTP-binding protein EngA YP_599901.1 303683 D 370565 CDS YP_599902.1 94991803 4064751 305200..308298 1 NC_008023.1 SWF/SNF family helicase 308298 snf 4064751 snf Streptococcus pyogenes MGAS2096 SWF/SNF family helicase YP_599902.1 305200 D 370565 CDS YP_599903.1 94991804 4066288 308541..309143 1 NC_008023.1 putative cytoplasmic protein 309143 4066288 MGAS2096_Spy0307 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_599903.1 308541 D 370565 CDS YP_599904.1 94991805 4066289 309183..310511 1 NC_008023.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 310511 murC 4066289 murC Streptococcus pyogenes MGAS2096 UDP-N-acetylmuramate--L-alanine ligase YP_599904.1 309183 D 370565 CDS YP_599905.1 94991806 4066290 310557..311039 1 NC_008023.1 acetyltransferase 311039 4066290 MGAS2096_Spy0309 Streptococcus pyogenes MGAS2096 acetyltransferase YP_599905.1 310557 D 370565 CDS YP_599906.1 94991807 4066291 311151..312725 1 NC_008023.1 hypothetical protein 312725 4066291 MGAS2096_Spy0310 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599906.1 311151 D 370565 CDS YP_599907.1 94991808 4066292 312750..313280 1 NC_008023.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 313280 greA 4066292 greA Streptococcus pyogenes MGAS2096 transcription elongation factor GreA YP_599907.1 312750 D 370565 CDS YP_599908.1 94991809 4066293 complement(313495..313638) 1 NC_008023.1 transposase 313638 4066293 MGAS2096_Spy0312 Streptococcus pyogenes MGAS2096 transposase YP_599908.1 313495 R 370565 CDS YP_599909.1 94991810 4066294 complement(313904..314827) 1 NC_008023.1 involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site; OxaA-like protein precursor 314827 4066294 MGAS2096_Spy0313 Streptococcus pyogenes MGAS2096 OxaA-like protein precursor YP_599909.1 313904 R 370565 CDS YP_599910.1 94991811 4066295 complement(314909..315220) 1 NC_008023.1 catalyzes the hydrolysis of acylphosphate; acylphosphatase 315220 4066295 MGAS2096_Spy0314 Streptococcus pyogenes MGAS2096 acylphosphatase YP_599910.1 314909 R 370565 CDS YP_599911.1 94991812 4066296 315448..316185 1 NC_008023.1 23S rRNA methyltransferase 316185 4066296 MGAS2096_Spy0315 Streptococcus pyogenes MGAS2096 23S rRNA methyltransferase YP_599911.1 315448 D 370565 CDS YP_599912.1 94991813 4066297 316224..316724 1 NC_008023.1 HAD superfamily; hydrolase 316724 4066297 MGAS2096_Spy0316 Streptococcus pyogenes MGAS2096 hydrolase YP_599912.1 316224 D 370565 CDS YP_599913.1 94991814 4066298 316739..317428 1 NC_008023.1 integral membrane protein 317428 4066298 MGAS2096_Spy0317 Streptococcus pyogenes MGAS2096 integral membrane protein YP_599913.1 316739 D 370565 CDS YP_599914.1 94991815 4066299 317606..317848 1 NC_008023.1 hypothetical protein 317848 4066299 MGAS2096_Spy0318 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599914.1 317606 D 370565 CDS YP_599915.1 94991816 4066300 complement(317906..318001) 1 NC_008023.1 putative cytoplasmic protein 318001 4066300 MGAS2096_Spy0319 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_599915.1 317906 R 370565 CDS YP_599916.1 94991817 4066301 318026..318820 1 NC_008023.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 318820 glr 4066301 glr Streptococcus pyogenes MGAS2096 glutamate racemase YP_599916.1 318026 D 370565 CDS YP_599917.1 94991818 4066302 318778..319803 1 NC_008023.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein 319803 4066302 MGAS2096_Spy0321 Streptococcus pyogenes MGAS2096 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein YP_599917.1 318778 D 370565 CDS YP_599918.1 94991819 4066303 319782..320303 1 NC_008023.1 putative phosphoesterase 320303 4066303 MGAS2096_Spy0322 Streptococcus pyogenes MGAS2096 putative phosphoesterase YP_599918.1 319782 D 370565 CDS YP_599919.1 94991820 4066304 320300..320761 1 NC_008023.1 hypothetical protein 320761 4066304 MGAS2096_Spy0323 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599919.1 320300 D 370565 CDS YP_599920.1 94991821 4066305 320758..321504 1 NC_008023.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 321504 xerD 4066305 xerD Streptococcus pyogenes MGAS2096 site-specific tyrosine recombinase XerD YP_599920.1 320758 D 370565 CDS YP_599921.1 94991822 4066306 321504..322208 1 NC_008023.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB; segregation and condensation protein A 322208 scpA 4066306 scpA Streptococcus pyogenes MGAS2096 segregation and condensation protein A YP_599921.1 321504 D 370565 CDS YP_599922.1 94991823 4065156 322205..322756 1 NC_008023.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer; segregation and condensation protein B 322756 scpB 4065156 scpB Streptococcus pyogenes MGAS2096 segregation and condensation protein B YP_599922.1 322205 D 370565 CDS YP_599923.1 94991824 4065157 322937..323599 1 NC_008023.1 ribosomal large subunit pseudouridine synthase B 323599 4065157 MGAS2096_Spy0327 Streptococcus pyogenes MGAS2096 ribosomal large subunit pseudouridine synthase B YP_599923.1 322937 D 370565 CDS YP_599924.1 94991825 4065158 323596..323859 1 NC_008023.1 hypothetical protein 323859 4065158 MGAS2096_Spy0328 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599924.1 323596 D 370565 CDS YP_599925.1 94991826 4065159 324001..324585 1 NC_008023.1 23S rRNA methyltransferase 324585 4065159 MGAS2096_Spy0329 Streptococcus pyogenes MGAS2096 23S rRNA methyltransferase YP_599925.1 324001 D 370565 CDS YP_599926.1 94991827 4065160 324897..325460 1 NC_008023.1 riboflavin transporter 325460 4065160 MGAS2096_Spy0330 Streptococcus pyogenes MGAS2096 riboflavin transporter YP_599926.1 324897 D 370565 CDS YP_599927.1 94991828 4065161 325462..326115 1 NC_008023.1 membrane-associated phospholipid phosphatase 326115 4065161 MGAS2096_Spy0331 Streptococcus pyogenes MGAS2096 membrane-associated phospholipid phosphatase YP_599927.1 325462 D 370565 CDS YP_599928.1 94991829 4065162 326390..327328 1 NC_008023.1 radical SAM superfamily protein 327328 4065162 MGAS2096_Spy0332 Streptococcus pyogenes MGAS2096 radical SAM superfamily protein YP_599928.1 326390 D 370565 CDS YP_599929.1 94991830 4065163 327340..327921 1 NC_008023.1 SAM-dependent methyltransferase 327921 4065163 MGAS2096_Spy0333 Streptococcus pyogenes MGAS2096 SAM-dependent methyltransferase YP_599929.1 327340 D 370565 CDS YP_599930.1 94991831 4065164 328015..329388 1 NC_008023.1 magnesium and cobalt efflux protein corC 329388 hlyX 4065164 hlyX Streptococcus pyogenes MGAS2096 magnesium and cobalt efflux protein corC YP_599930.1 328015 D 370565 CDS YP_599931.1 94991832 4065165 329394..330257 1 NC_008023.1 pyruvate formate-lyase activating enzyme 330257 pflC 4065165 pflC Streptococcus pyogenes MGAS2096 pyruvate formate-lyase activating enzyme YP_599931.1 329394 D 370565 CDS YP_599932.1 94991833 4065166 330382..331323 1 NC_008023.1 catalyzes the hydrolysis of pyrophosphate to phosphate; putative manganese-dependent inorganic pyrophosphatase 331323 ppaC 4065166 ppaC Streptococcus pyogenes MGAS2096 putative manganese-dependent inorganic pyrophosphatase YP_599932.1 330382 D 370565 CDS YP_599933.1 94991834 4065167 331399..332052 1 NC_008023.1 putative cytoplasmic protein 332052 4065167 MGAS2096_Spy0337 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_599933.1 331399 D 370565 CDS YP_599934.1 94991835 4065168 complement(332097..333134) 1 NC_008023.1 ferrichrome transport system permease fhuG 333134 fhuG 4065168 fhuG Streptococcus pyogenes MGAS2096 ferrichrome transport system permease fhuG YP_599934.1 332097 R 370565 CDS YP_599935.1 94991836 4065169 complement(333095..334147) 1 NC_008023.1 ferrichrome transport system permease fhuB 334147 fhuB 4065169 fhuB Streptococcus pyogenes MGAS2096 ferrichrome transport system permease fhuB YP_599935.1 333095 R 370565 CDS YP_599936.1 94991837 4065170 complement(334137..335069) 1 NC_008023.1 ferrichrome-binding protein 335069 fhuD 4065170 fhuD Streptococcus pyogenes MGAS2096 ferrichrome-binding protein YP_599936.1 334137 R 370565 CDS YP_599937.1 94991838 4065171 complement(335095..335877) 1 NC_008023.1 ferrichrome ABC transporter ATP-binding protein 335877 fhuA 4065171 fhuA Streptococcus pyogenes MGAS2096 ferrichrome ABC transporter ATP-binding protein YP_599937.1 335095 R 370565 CDS YP_599938.1 94991839 4065172 complement(336123..336488) 1 NC_008023.1 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-- lysine ligase 336488 4065172 MGAS2096_Spy0342 Streptococcus pyogenes MGAS2096 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-- lysine ligase YP_599938.1 336123 R 370565 CDS YP_599939.1 94991840 4065173 complement(336506..337567) 1 NC_008023.1 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-- lysine ligase 337567 murE 4065173 murE Streptococcus pyogenes MGAS2096 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-- lysine ligase YP_599939.1 336506 R 370565 CDS YP_599940.1 94991841 4065174 337655..339289 1 NC_008023.1 export protein for polysaccharides and teichoic acids 339289 4065174 MGAS2096_Spy0344 Streptococcus pyogenes MGAS2096 export protein for polysaccharides and teichoic acids YP_599940.1 337655 D 370565 CDS YP_599941.1 94991842 4065175 339457..339606 1 NC_008023.1 uracil phosphoribosyltransferase 339606 4065175 MGAS2096_Spy0345 Streptococcus pyogenes MGAS2096 uracil phosphoribosyltransferase YP_599941.1 339457 D 370565 CDS YP_599942.1 94991843 4065058 339706..340086 1 NC_008023.1 uracil phosphoribosyltransferase 340086 upp 4065058 upp Streptococcus pyogenes MGAS2096 uracil phosphoribosyltransferase YP_599942.1 339706 D 370565 CDS YP_599943.1 94991844 4065059 340310..340900 1 NC_008023.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 340900 clpP 4065059 clpP Streptococcus pyogenes MGAS2096 ATP-dependent Clp protease proteolytic subunit YP_599943.1 340310 D 370565 CDS YP_599944.1 94991845 4065060 341941..343083 1 NC_008023.1 transposase 343083 4065060 MGAS2096_Spy0348 Streptococcus pyogenes MGAS2096 transposase YP_599944.1 341941 D 370565 CDS YP_599945.1 94991846 4065061 343088..343219 1 NC_008023.1 hypothetical protein 343219 4065061 MGAS2096_Spy0349 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599945.1 343088 D 370565 CDS YP_599946.1 94991847 4065062 343168..343881 1 NC_008023.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 343881 tmk 4065062 tmk Streptococcus pyogenes MGAS2096 thymidylate kinase YP_599946.1 343168 D 370565 CDS YP_599947.1 94991848 4065063 343899..344774 1 NC_008023.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA.; DNA polymerase III subunit delta' 344774 dnaX 4065063 dnaX Streptococcus pyogenes MGAS2096 DNA polymerase III subunit delta' YP_599947.1 343899 D 370565 CDS YP_599948.1 94991849 4065064 344896..345033 1 NC_008023.1 tpl protein 345033 4065064 MGAS2096_Spy0352 Streptococcus pyogenes MGAS2096 tpl protein YP_599948.1 344896 D 370565 CDS YP_599949.1 94991850 4065065 complement(345177..345341) 1 NC_008023.1 putative cytoplasmic protein 345341 4065065 MGAS2096_Spy0353 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_599949.1 345177 R 370565 CDS YP_599950.1 94991851 4065066 345438..345761 1 NC_008023.1 in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA; DNA replication intiation control protein YabA 345761 4065066 MGAS2096_Spy0354 Streptococcus pyogenes MGAS2096 DNA replication intiation control protein YabA YP_599950.1 345438 D 370565 CDS YP_599951.1 94991852 4065067 345766..346629 1 NC_008023.1 tetrapyrrole (Corrin/Porphyrin) methylase family protein 346629 4065067 MGAS2096_Spy0355 Streptococcus pyogenes MGAS2096 tetrapyrrole (Corrin/Porphyrin) methylase family protein YP_599951.1 345766 D 370565 CDS YP_599952.1 94991853 4065068 346710..347051 1 NC_008023.1 hypothetical protein 347051 4065068 MGAS2096_Spy0356 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599952.1 346710 D 370565 CDS YP_599953.1 94991854 4065069 complement(347098..347727) 1 NC_008023.1 copper homeostasis protein cutC 347727 cutC 4065069 cutC Streptococcus pyogenes MGAS2096 copper homeostasis protein cutC YP_599953.1 347098 R 370565 CDS YP_599954.1 94991855 4065070 348026..348382 1 NC_008023.1 arsenate reductase family protein 348382 4065070 MGAS2096_Spy0358 Streptococcus pyogenes MGAS2096 arsenate reductase family protein YP_599954.1 348026 D 370565 CDS YP_599955.1 94991856 4065071 complement(348456..349367) 1 NC_008023.1 exodeoxyribonuclease III 349367 exoA 4065071 exoA Streptococcus pyogenes MGAS2096 exodeoxyribonuclease III YP_599955.1 348456 R 370565 CDS YP_599956.1 94991857 4065072 349511..350698 1 NC_008023.1 L-lactate oxidase 350698 lctO 4065072 lctO Streptococcus pyogenes MGAS2096 L-lactate oxidase YP_599956.1 349511 D 370565 CDS YP_599957.1 94991858 4065073 350963..355906 1 NC_008023.1 interleukin-8 protease 355906 spyCEP 4065073 spyCEP Streptococcus pyogenes MGAS2096 interleukin-8 protease YP_599957.1 350963 D 370565 CDS YP_599958.1 94991859 4065074 356397..356576 1 NC_008023.1 hypothetical protein 356576 4065074 MGAS2096_Spy0362 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599958.1 356397 D 370565 CDS YP_599959.1 94991860 4065075 356654..357385 1 NC_008023.1 hypothetical protein 357385 4065075 MGAS2096_Spy0363 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599959.1 356654 D 370565 CDS YP_599960.1 94991861 4065076 357626..359626 1 NC_008023.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 359626 metS 4065076 metS Streptococcus pyogenes MGAS2096 methionyl-tRNA synthetase YP_599960.1 357626 D 370565 CDS YP_599961.1 94991862 4064923 359954..360124 1 NC_008023.1 hypothetical protein 360124 4064923 MGAS2096_Spy0365 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599961.1 359954 D 370565 CDS YP_599962.1 94991863 4064924 360121..361134 1 NC_008023.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 361134 nrdF 4064924 nrdF Streptococcus pyogenes MGAS2096 ribonucleotide-diphosphate reductase subunit beta YP_599962.1 360121 D 370565 CDS YP_599963.1 94991864 4064925 361138..361626 1 NC_008023.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 361626 nrdI 4064925 nrdI Streptococcus pyogenes MGAS2096 ribonucleotide reductase stimulatory protein YP_599963.1 361138 D 370565 CDS YP_599964.1 94991865 4064926 361593..363773 1 NC_008023.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 363773 nrdE1 4064926 nrdE1 Streptococcus pyogenes MGAS2096 ribonucleotide-diphosphate reductase subunit alpha YP_599964.1 361593 D 370565 CDS YP_599965.1 94991866 4064927 363793..363972 1 NC_008023.1 hypothetical protein 363972 4064927 MGAS2096_Spy0369 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599965.1 363793 D 370565 CDS YP_599966.1 94991867 4064928 complement(363978..364730) 1 NC_008023.1 C3 family ADP-ribosyltransferase 364730 spyA 4064928 spyA Streptococcus pyogenes MGAS2096 C3 family ADP-ribosyltransferase YP_599966.1 363978 R 370565 CDS YP_599967.1 94991868 4064929 365164..365676 1 NC_008023.1 hypothetical protein 365676 4064929 MGAS2096_Spy0371 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599967.1 365164 D 370565 CDS YP_599968.1 94991869 4064930 366154..366606 1 NC_008023.1 hypothetical protein 366606 4064930 MGAS2096_Spy0372 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599968.1 366154 D 370565 CDS YP_599969.1 94991870 4064931 367050..367463 1 NC_008023.1 hypothetical protein 367463 4064931 MGAS2096_Spy0373 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599969.1 367050 D 370565 CDS YP_599970.1 94991871 4064932 367656..367955 1 NC_008023.1 hypothetical protein 367955 4064932 MGAS2096_Spy0374 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599970.1 367656 D 370565 CDS YP_599971.1 94991872 4064933 complement(368048..368680) 1 NC_008023.1 hypothetical protein 368680 4064933 MGAS2096_Spy0375 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599971.1 368048 R 370565 CDS YP_599972.1 94991873 4064934 complement(369192..370160) 1 NC_008023.1 hypothetical protein 370160 4064934 MGAS2096_Spy0376 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599972.1 369192 R 370565 CDS YP_599973.1 94991874 4064935 370613..371008 1 NC_008023.1 hypothetical protein 371008 4064935 MGAS2096_Spy0377 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599973.1 370613 D 370565 CDS YP_599974.1 94991875 4064936 371001..371699 1 NC_008023.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 371699 fabG 4064936 fabG Streptococcus pyogenes MGAS2096 3-ketoacyl-ACP reductase YP_599974.1 371001 D 370565 CDS YP_599975.1 94991876 4064937 371742..372734 1 NC_008023.1 NAD-dependent oxidoreductase 372734 4064937 MGAS2096_Spy0379 Streptococcus pyogenes MGAS2096 NAD-dependent oxidoreductase YP_599975.1 371742 D 370565 CDS YP_599976.1 94991877 4064938 373061..374404 1 NC_008023.1 phosphoglycerate transporter 374404 4064938 MGAS2096_Spy0380 Streptococcus pyogenes MGAS2096 phosphoglycerate transporter YP_599976.1 373061 D 370565 CDS YP_599977.1 94991878 4064939 374577..375827 1 NC_008023.1 bifunctional; glucosamine-1-phosphate acetyltransferase / UDP-N-acetylglucosamine pyrophosphorylase 375827 gcaD 4064939 gcaD Streptococcus pyogenes MGAS2096 glucosamine-1-phosphate acetyltransferase / UDP-N-acetylglucosamine pyrophosphorylase YP_599977.1 374577 D 370565 CDS YP_599978.1 94991879 4064940 375994..376548 1 NC_008023.1 ADP-ribose pyrophosphatase 376548 4064940 MGAS2096_Spy0382 Streptococcus pyogenes MGAS2096 ADP-ribose pyrophosphatase YP_599978.1 375994 D 370565 CDS YP_599979.1 94991880 4064941 376545..376799 1 NC_008023.1 hypothetical protein 376799 4064941 MGAS2096_Spy0383 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599979.1 376545 D 370565 CDS YP_599980.1 94991881 4064942 376819..377514 1 NC_008023.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 377514 pfs 4064942 pfs Streptococcus pyogenes MGAS2096 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_599980.1 376819 D 370565 CDS YP_599981.1 94991882 4065342 377627..377845 1 NC_008023.1 hypothetical protein 377845 4065342 MGAS2096_Spy0385 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599981.1 377627 D 370565 CDS YP_599982.1 94991883 4065343 complement(377942..378343) 1 NC_008023.1 Iron-dependent repressor 378343 scaR 4065343 scaR Streptococcus pyogenes MGAS2096 Iron-dependent repressor YP_599982.1 377942 R 370565 CDS YP_599983.1 94991884 4065344 complement(378340..378588) 1 NC_008023.1 Iron-dependent repressor 378588 4065344 MGAS2096_Spy0387 Streptococcus pyogenes MGAS2096 Iron-dependent repressor YP_599983.1 378340 R 370565 CDS YP_599984.1 94991885 4065345 378731..379666 1 NC_008023.1 manganese-binding protein 379666 mtsA 4065345 mtsA Streptococcus pyogenes MGAS2096 manganese-binding protein YP_599984.1 378731 D 370565 CDS YP_599985.1 94991886 4065346 379703..380455 1 NC_008023.1 manganese transport system ATP-binding protein 380455 mtsB 4065346 mtsB Streptococcus pyogenes MGAS2096 manganese transport system ATP-binding protein YP_599985.1 379703 D 370565 CDS YP_599986.1 94991887 4065347 380456..381310 1 NC_008023.1 manganese transport system membrane protein 381310 mtsC 4065347 mtsC Streptococcus pyogenes MGAS2096 manganese transport system membrane protein YP_599986.1 380456 D 370565 CDS YP_599987.1 94991888 4065348 complement(381458..382264) 1 NC_008023.1 peptidyl-prolyl cis-trans isomerase 382264 4065348 MGAS2096_Spy0391 Streptococcus pyogenes MGAS2096 peptidyl-prolyl cis-trans isomerase YP_599987.1 381458 R 370565 CDS YP_599988.1 94991889 4065349 382481..384736 1 NC_008023.1 cell division protein ftsK 384736 ftsK 4065349 ftsK Streptococcus pyogenes MGAS2096 cell division protein ftsK YP_599988.1 382481 D 370565 CDS YP_599989.1 94991890 4065350 384727..384885 1 NC_008023.1 cell division protein ftsK 384885 4065350 MGAS2096_Spy0393 Streptococcus pyogenes MGAS2096 cell division protein ftsK YP_599989.1 384727 D 370565 CDS YP_599990.1 94991891 4065351 complement(384955..385308) 1 NC_008023.1 integral membrane protein 385308 4065351 MGAS2096_Spy0394 Streptococcus pyogenes MGAS2096 integral membrane protein YP_599990.1 384955 R 370565 CDS YP_599991.2 162139137 4065352 385552..385977 1 NC_008023.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 385977 rplK 4065352 rplK Streptococcus pyogenes MGAS2096 50S ribosomal protein L11 YP_599991.2 385552 D 370565 CDS YP_599992.1 94991893 4065353 386083..386772 1 NC_008023.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 386772 rplA 4065353 rplA Streptococcus pyogenes MGAS2096 50S ribosomal protein L1 YP_599992.1 386083 D 370565 CDS YP_599993.1 94991894 4065354 387094..387822 1 NC_008023.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 387822 pyrH 4065354 pyrH Streptococcus pyogenes MGAS2096 uridylate kinase YP_599993.1 387094 D 370565 CDS YP_599994.1 94991895 4065355 387851..388408 1 NC_008023.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 388408 frr 4065355 frr Streptococcus pyogenes MGAS2096 ribosome recycling factor YP_599994.1 387851 D 370565 CDS YP_599995.1 94991896 4065356 388517..389374 1 NC_008023.1 S1 RNA-binding domain-containing protein 389374 4065356 MGAS2096_Spy0399 Streptococcus pyogenes MGAS2096 S1 RNA-binding domain-containing protein YP_599995.1 388517 D 370565 CDS YP_599996.1 94991897 4065357 389447..389956 1 NC_008023.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 389956 msrA2 4065357 msrA2 Streptococcus pyogenes MGAS2096 methionine sulfoxide reductase A YP_599996.1 389447 D 370565 CDS YP_599997.1 94991898 4065358 389953..390168 1 NC_008023.1 hypothetical protein 390168 4065358 MGAS2096_Spy0401 Streptococcus pyogenes MGAS2096 hypothetical protein YP_599997.1 389953 D 370565 CDS YP_599998.1 94991899 4065359 390349..391491 1 NC_008023.1 surface antigen 391491 4065359 MGAS2096_Spy0402 Streptococcus pyogenes MGAS2096 surface antigen YP_599998.1 390349 D 370565 CDS YP_599999.1 94991900 4065360 391764..392183 1 NC_008023.1 myosin-crossreactive antigen 392183 4065360 MGAS2096_Spy0403 Streptococcus pyogenes MGAS2096 myosin-crossreactive antigen YP_599999.1 391764 D 370565 CDS YP_600000.1 94991901 4065673 392144..393577 1 NC_008023.1 myosin-crossreactive antigen 393577 4065673 MGAS2096_Spy0404 Streptococcus pyogenes MGAS2096 myosin-crossreactive antigen YP_600000.1 392144 D 370565 CDS YP_600001.1 94991902 4065674 393736..394254 1 NC_008023.1 PhoH protein 394254 4065674 MGAS2096_Spy0405 Streptococcus pyogenes MGAS2096 PhoH protein YP_600001.1 393736 D 370565 CDS YP_600002.1 94991903 4065675 394226..394789 1 NC_008023.1 PhoH protein 394789 phoH 4065675 phoH Streptococcus pyogenes MGAS2096 PhoH protein YP_600002.1 394226 D 370565 CDS YP_600003.1 94991904 4065676 394835..395410 1 NC_008023.1 Uracil DNA glycosylase superfamily protein 395410 4065676 MGAS2096_Spy0407 Streptococcus pyogenes MGAS2096 Uracil DNA glycosylase superfamily protein YP_600003.1 394835 D 370565 CDS YP_600004.1 94991905 4065677 395518..396066 1 NC_008023.1 putative metalloprotease 396066 4065677 MGAS2096_Spy0408 Streptococcus pyogenes MGAS2096 putative metalloprotease YP_600004.1 395518 D 370565 CDS YP_600005.1 94991906 4065678 396047..396454 1 NC_008023.1 diacylglycerol kinase 396454 dgk 4065678 dgk Streptococcus pyogenes MGAS2096 diacylglycerol kinase YP_600005.1 396047 D 370565 CDS YP_600006.1 94991907 4065679 396574..397470 1 NC_008023.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 397470 era 4065679 era Streptococcus pyogenes MGAS2096 GTP-binding protein Era YP_600006.1 396574 D 370565 CDS YP_600007.1 94991908 4065680 397445..397966 1 NC_008023.1 MutT/nudix family protein; phosphohydrolase 397966 4065680 MGAS2096_Spy0411 Streptococcus pyogenes MGAS2096 phosphohydrolase YP_600007.1 397445 D 370565 CDS YP_600008.1 94991909 4065681 complement(398272..398526) 1 NC_008023.1 hypothetical protein 398526 4065681 MGAS2096_Spy0412 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600008.1 398272 R 370565 CDS YP_600009.1 94991910 4065682 complement(398754..399335) 1 NC_008023.1 transposase 399335 4065682 MGAS2096_Spy0413 Streptococcus pyogenes MGAS2096 transposase YP_600009.1 398754 R 370565 CDS YP_600010.1 94991911 4065683 399495..399806 1 NC_008023.1 bacteriocin 399806 4065683 MGAS2096_Spy0414 Streptococcus pyogenes MGAS2096 bacteriocin YP_600010.1 399495 D 370565 CDS YP_600011.1 94991912 4065684 399819..400019 1 NC_008023.1 hypothetical protein 400019 4065684 MGAS2096_Spy0415 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600011.1 399819 D 370565 CDS YP_600012.1 94991913 4065685 400313..400507 1 NC_008023.1 hypothetical protein 400507 silD 4065685 silD Streptococcus pyogenes MGAS2096 hypothetical protein YP_600012.1 400313 D 370565 CDS YP_600013.1 94991914 4065686 400557..400853 1 NC_008023.1 hypothetical protein 400853 4065686 MGAS2096_Spy0417 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600013.1 400557 D 370565 CDS YP_600014.1 94991915 4065687 401032..401433 1 NC_008023.1 hypothetical protein 401433 4065687 MGAS2096_Spy0418 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600014.1 401032 D 370565 CDS YP_600015.1 94991916 4065688 complement(401472..401588) 1 NC_008023.1 hypothetical protein 401588 4065688 MGAS2096_Spy0419 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600015.1 401472 R 370565 CDS YP_600016.1 94991917 4065689 401684..402754 1 NC_008023.1 hypothetical protein 402754 4065689 MGAS2096_Spy0420 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600016.1 401684 D 370565 CDS YP_600017.1 94991918 4065690 402847..403245 1 NC_008023.1 hypothetical protein 403245 4065690 MGAS2096_Spy0421 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600017.1 402847 D 370565 CDS YP_600018.1 94991919 4065691 complement(403593..403862) 1 NC_008023.1 hypothetical protein 403862 4065691 MGAS2096_Spy0422 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600018.1 403593 R 370565 CDS YP_600019.1 94991920 4065692 404063..404170 1 NC_008023.1 hypothetical protein 404170 4065692 MGAS2096_Spy0423 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600019.1 404063 D 370565 CDS YP_600020.1 94991921 4064962 complement(404257..404436) 1 NC_008023.1 hypothetical protein 404436 4064962 MGAS2096_Spy0424 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600020.1 404257 R 370565 CDS YP_600021.1 94991922 4064963 complement(404385..404627) 1 NC_008023.1 hypothetical protein 404627 4064963 MGAS2096_Spy0425 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600021.1 404385 R 370565 CDS YP_600022.1 94991923 4064964 404919..405800 1 NC_008023.1 transcriptional regulator 405800 mutR 4064964 mutR Streptococcus pyogenes MGAS2096 transcriptional regulator YP_600022.1 404919 D 370565 CDS YP_600023.1 94991924 4064965 405972..406799 1 NC_008023.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 406799 fpg 4064965 fpg Streptococcus pyogenes MGAS2096 formamidopyrimidine-DNA glycosylase YP_600023.1 405972 D 370565 CDS YP_600024.1 94991925 4064966 406769..407389 1 NC_008023.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 407389 coaE 4064966 coaE Streptococcus pyogenes MGAS2096 dephospho-CoA kinase YP_600024.1 406769 D 370565 CDS YP_600025.1 94991926 4064967 407579..409081 1 NC_008023.1 ATPase 409081 4064967 MGAS2096_Spy0429 Streptococcus pyogenes MGAS2096 ATPase YP_600025.1 407579 D 370565 CDS YP_600026.1 94991927 4064968 409203..410396 1 NC_008023.1 multidrug resistance efflux pump 410396 4064968 MGAS2096_Spy0430 Streptococcus pyogenes MGAS2096 multidrug resistance efflux pump YP_600026.1 409203 D 370565 CDS YP_600027.1 94991928 4064969 410393..410539 1 NC_008023.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 410539 rpmG 4064969 rpmG Streptococcus pyogenes MGAS2096 50S ribosomal protein L33 YP_600027.1 410393 D 370565 CDS YP_600028.1 94991929 4064970 410585..410821 1 NC_008023.1 preprotein translocase subunit SecG 410821 secG 4064970 secG Streptococcus pyogenes MGAS2096 preprotein translocase subunit SecG YP_600028.1 410585 D 370565 CDS YP_600029.1 94991930 4064971 410915..413248 1 NC_008023.1 exoribonuclease II 413248 4064971 MGAS2096_Spy0433 Streptococcus pyogenes MGAS2096 exoribonuclease II YP_600029.1 410915 D 370565 CDS YP_600030.1 94991931 4064972 413251..413718 1 NC_008023.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 413718 smpB 4064972 smpB Streptococcus pyogenes MGAS2096 SsrA-binding protein YP_600030.1 413251 D 370565 CDS YP_600031.1 94991932 4064973 413724..414443 1 NC_008023.1 glutaminyl-peptide cyclotransferase 414443 4064973 MGAS2096_Spy0435 Streptococcus pyogenes MGAS2096 glutaminyl-peptide cyclotransferase YP_600031.1 413724 D 370565 CDS YP_600032.1 94991933 4064974 complement(414558..415205) 1 NC_008023.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 415205 pcp 4064974 pcp Streptococcus pyogenes MGAS2096 pyrrolidone-carboxylate peptidase YP_600032.1 414558 R 370565 CDS YP_600033.1 94991934 4064975 complement(415255..416181) 1 NC_008023.1 permease 416181 4064975 MGAS2096_Spy0437 Streptococcus pyogenes MGAS2096 permease YP_600033.1 415255 R 370565 CDS YP_600034.1 94991935 4064976 complement(416181..416921) 1 NC_008023.1 permease 416921 4064976 MGAS2096_Spy0438 Streptococcus pyogenes MGAS2096 permease YP_600034.1 416181 R 370565 CDS YP_600035.1 94991936 4064977 complement(417075..418061) 1 NC_008023.1 bactoprenol glucosyl transferase 418061 4064977 MGAS2096_Spy0439 Streptococcus pyogenes MGAS2096 bactoprenol glucosyl transferase YP_600035.1 417075 R 370565 CDS YP_600036.1 94991937 4064978 complement(418146..418523) 1 NC_008023.1 lactoylglutathione lyase 418523 gloA 4064978 gloA Streptococcus pyogenes MGAS2096 lactoylglutathione lyase YP_600036.1 418146 R 370565 CDS YP_600037.1 94991938 4064979 complement(418534..419199) 1 NC_008023.1 NAD(P)H-dependent quinone reductase 419199 4064979 MGAS2096_Spy0441 Streptococcus pyogenes MGAS2096 NAD(P)H-dependent quinone reductase YP_600037.1 418534 R 370565 CDS YP_600038.1 94991939 4064980 complement(419248..420333) 1 NC_008023.1 Xaa-Pro aminopeptidase 420333 pepQ 4064980 pepQ Streptococcus pyogenes MGAS2096 Xaa-Pro aminopeptidase YP_600038.1 419248 R 370565 CDS YP_600039.1 94991940 4065459 420517..421509 1 NC_008023.1 catabolite control protein A 421509 ccpA 4065459 ccpA Streptococcus pyogenes MGAS2096 catabolite control protein A YP_600039.1 420517 D 370565 CDS YP_600040.1 94991941 4065460 421640..422638 1 NC_008023.1 glycosyltransferase 422638 4065460 MGAS2096_Spy0444 Streptococcus pyogenes MGAS2096 glycosyltransferase YP_600040.1 421640 D 370565 CDS YP_600041.1 94991942 4065461 422640..423974 1 NC_008023.1 1,2-diacylglycerol 3-glucosyltransferase 423974 4065461 MGAS2096_Spy0445 Streptococcus pyogenes MGAS2096 1,2-diacylglycerol 3-glucosyltransferase YP_600041.1 422640 D 370565 CDS YP_600042.1 94991943 4065462 424396..426339 1 NC_008023.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 426339 thrS 4065462 thrS Streptococcus pyogenes MGAS2096 threonyl-tRNA synthetase YP_600042.1 424396 D 370565 CDS YP_600043.1 94991944 4065463 426480..427472 1 NC_008023.1 daunorubicin resistance ATP-binding protein drrA 427472 drrA 4065463 drrA Streptococcus pyogenes MGAS2096 daunorubicin resistance ATP-binding protein drrA YP_600043.1 426480 D 370565 CDS YP_600044.1 94991945 4065464 427423..428292 1 NC_008023.1 daunorubicin resistance transmembrane protein 428292 4065464 MGAS2096_Spy0448 Streptococcus pyogenes MGAS2096 daunorubicin resistance transmembrane protein YP_600044.1 427423 D 370565 CDS YP_600045.1 94991946 4065465 428294..429079 1 NC_008023.1 ABC transporter permease 429079 4065465 MGAS2096_Spy0449 Streptococcus pyogenes MGAS2096 ABC transporter permease YP_600045.1 428294 D 370565 CDS YP_600046.1 94991947 4065466 429165..429314 1 NC_008023.1 dihydroxyacetone kinase 429314 4065466 MGAS2096_Spy0450 Streptococcus pyogenes MGAS2096 dihydroxyacetone kinase YP_600046.1 429165 D 370565 CDS YP_600047.1 94991948 4065467 429709..430857 1 NC_008023.1 Acetyl-CoA acetyltransferase 430857 4065467 MGAS2096_Spy0451 Streptococcus pyogenes MGAS2096 Acetyl-CoA acetyltransferase YP_600047.1 429709 D 370565 CDS YP_600048.1 94991949 4065468 430814..432061 1 NC_008023.1 long-chain-fatty-acid--CoA ligase 432061 4065468 MGAS2096_Spy0452 Streptococcus pyogenes MGAS2096 long-chain-fatty-acid--CoA ligase YP_600048.1 430814 D 370565 CDS YP_600049.1 94991950 4065469 432117..433151 1 NC_008023.1 putative cytoplasmic protein 433151 4065469 MGAS2096_Spy0453 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600049.1 432117 D 370565 CDS YP_600050.1 94991951 4065470 433313..434023 1 NC_008023.1 two-component response regulator VicR 434023 vicR 4065470 vicR Streptococcus pyogenes MGAS2096 two-component response regulator VicR YP_600050.1 433313 D 370565 CDS YP_600051.1 94991952 4065471 434016..435368 1 NC_008023.1 two-component sensor histidine kinase VicK 435368 vicK 4065471 vicK Streptococcus pyogenes MGAS2096 two-component sensor histidine kinase VicK YP_600051.1 434016 D 370565 CDS YP_600052.1 94991953 4065472 435372..436181 1 NC_008023.1 beta-lactamase superfamily; Zn-dependent hydrolase 436181 vicX 4065472 vicX Streptococcus pyogenes MGAS2096 Zn-dependent hydrolase YP_600052.1 435372 D 370565 CDS YP_600053.1 94991954 4065473 436613..437305 1 NC_008023.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 437305 rnc 4065473 rnc Streptococcus pyogenes MGAS2096 ribonuclease III YP_600053.1 436613 D 370565 CDS YP_600054.1 94991955 4065474 437306..440845 1 NC_008023.1 chromosome partition protein smc 440845 smc 4065474 smc Streptococcus pyogenes MGAS2096 chromosome partition protein smc YP_600054.1 437306 D 370565 CDS YP_600055.1 94991956 4065475 complement(441098..441970) 1 NC_008023.1 transcriptional regulator 441970 4065475 MGAS2096_Spy0459 Streptococcus pyogenes MGAS2096 transcriptional regulator YP_600055.1 441098 R 370565 CDS YP_600056.1 94991957 4065476 442169..443095 1 NC_008023.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 443095 aroE 4065476 aroE Streptococcus pyogenes MGAS2096 shikimate 5-dehydrogenase YP_600056.1 442169 D 370565 CDS YP_600057.1 94991958 4065477 443092..443928 1 NC_008023.1 putative cytoplasmic protein 443928 4065477 MGAS2096_Spy0461 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600057.1 443092 D 370565 CDS YP_600058.1 94991959 4065478 443906..444664 1 NC_008023.1 hypothetical protein 444664 4065478 MGAS2096_Spy0462 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600058.1 443906 D 370565 CDS YP_600059.1 94991960 4065615 444657..445643 1 NC_008023.1 hypothetical protein 445643 4065615 MGAS2096_Spy0463 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600059.1 444657 D 370565 CDS YP_600060.1 94991961 4065616 445653..446852 1 NC_008023.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; S-adenosylmethionine synthetase 446852 metK1 4065616 metK1 Streptococcus pyogenes MGAS2096 S-adenosylmethionine synthetase YP_600060.1 445653 D 370565 CDS YP_600061.1 94991962 4065617 446836..447804 1 NC_008023.1 hypothetical protein 447804 4065617 MGAS2096_Spy0465 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600061.1 446836 D 370565 CDS YP_600062.1 94991963 4065618 447859..448848 1 NC_008023.1 cell wall biosynthesis glycosyltransferase 448848 4065618 MGAS2096_Spy0466 Streptococcus pyogenes MGAS2096 cell wall biosynthesis glycosyltransferase YP_600062.1 447859 D 370565 CDS YP_600063.1 94991964 4065619 449357..449494 1 NC_008023.1 hypothetical protein 449494 4065619 MGAS2096_Spy0467 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600063.1 449357 D 370565 CDS YP_600064.1 94991965 4065620 449518..450675 1 NC_008023.1 UDP-glucose 6-dehydrogenase 450675 4065620 MGAS2096_Spy0468 Streptococcus pyogenes MGAS2096 UDP-glucose 6-dehydrogenase YP_600064.1 449518 D 370565 CDS YP_600065.1 94991966 4065621 450760..451968 1 NC_008023.1 macrolide-efflux protein 451968 mefE 4065621 mefE Streptococcus pyogenes MGAS2096 macrolide-efflux protein YP_600065.1 450760 D 370565 CDS YP_600066.1 94991967 4065622 complement(452071..452280) 1 NC_008023.1 transcriptional regulator 452280 4065622 MGAS2096_Spy0470 Streptococcus pyogenes MGAS2096 transcriptional regulator YP_600066.1 452071 R 370565 CDS YP_600067.1 94991968 4065623 complement(452270..452743) 1 NC_008023.1 chromosome segregation ATPases 452743 4065623 MGAS2096_Spy0471 Streptococcus pyogenes MGAS2096 chromosome segregation ATPases YP_600067.1 452270 R 370565 CDS YP_600068.1 94991969 4065624 complement(452756..453928) 1 NC_008023.1 chromosome segregation ATPases 453928 4065624 MGAS2096_Spy0472 Streptococcus pyogenes MGAS2096 chromosome segregation ATPases YP_600068.1 452756 R 370565 CDS YP_600069.1 94991970 4065625 complement(453919..454101) 1 NC_008023.1 hypothetical protein 454101 4065625 MGAS2096_Spy0473 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600069.1 453919 R 370565 CDS YP_600070.1 94991971 4065626 complement(454144..455238) 1 NC_008023.1 hypothetical protein 455238 4065626 MGAS2096_Spy0474 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600070.1 454144 R 370565 CDS YP_600071.1 94991972 4065627 455257..455586 1 NC_008023.1 plasmid stabilization system antitoxin protein 455586 4065627 MGAS2096_Spy0475 Streptococcus pyogenes MGAS2096 plasmid stabilization system antitoxin protein YP_600071.1 455257 D 370565 CDS YP_600072.1 94991973 4065628 455586..455891 1 NC_008023.1 plasmid stabilization system toxin protein 455891 4065628 MGAS2096_Spy0476 Streptococcus pyogenes MGAS2096 plasmid stabilization system toxin protein YP_600072.1 455586 D 370565 CDS YP_600073.1 94991974 4065629 456024..456182 1 NC_008023.1 putative cytoplasmic protein 456182 4065629 MGAS2096_Spy0477 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600073.1 456024 D 370565 CDS YP_600074.1 94991975 4065630 456287..457060 1 NC_008023.1 hypothetical protein 457060 4065630 MGAS2096_Spy0478 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600074.1 456287 D 370565 CDS YP_600075.1 94991976 4065631 complement(457503..458234) 1 NC_008023.1 transposase 458234 4065631 MGAS2096_Spy0479 Streptococcus pyogenes MGAS2096 transposase YP_600075.1 457503 R 370565 CDS YP_600076.1 94991977 4065632 complement(458354..458674) 1 NC_008023.1 transposase 458674 4065632 MGAS2096_Spy0481 Streptococcus pyogenes MGAS2096 transposase YP_600076.1 458354 R 370565 CDS YP_600077.1 94991978 4065633 458649..458774 1 NC_008023.1 hypothetical protein 458774 4065633 MGAS2096_Spy0480 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600077.1 458649 D 370565 CDS YP_600078.1 94991979 4065518 complement(458756..458929) 1 NC_008023.1 hypothetical protein 458929 4065518 MGAS2096_Spy0482 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600078.1 458756 R 370565 CDS YP_600079.1 94991980 4065519 458933..459730 1 NC_008023.1 HAD superfamily; hydrolase 459730 4065519 MGAS2096_Spy0483 Streptococcus pyogenes MGAS2096 hydrolase YP_600079.1 458933 D 370565 CDS YP_600080.1 94991981 4065520 459734..460558 1 NC_008023.1 HAD superfamily; hydrolase 460558 4065520 MGAS2096_Spy0484 Streptococcus pyogenes MGAS2096 hydrolase YP_600080.1 459734 D 370565 CDS YP_600081.1 94991982 4065521 460558..462108 1 NC_008023.1 cell division protein ftsY 462108 ftsY 4065521 ftsY Streptococcus pyogenes MGAS2096 cell division protein ftsY YP_600081.1 460558 D 370565 CDS YP_600082.1 94991983 4065522 complement(462163..463530) 1 NC_008023.1 multidrug resistance protein B 463530 4065522 MGAS2096_Spy0486 Streptococcus pyogenes MGAS2096 multidrug resistance protein B YP_600082.1 462163 R 370565 CDS YP_600083.1 94991984 4065523 463857..464699 1 NC_008023.1 BigG family transcription antiterminator 464699 licT 4065523 licT Streptococcus pyogenes MGAS2096 BigG family transcription antiterminator YP_600083.1 463857 D 370565 CDS YP_600084.1 94991985 4065524 464701..466563 1 NC_008023.1 PTS system beta-glucoside-specific transporter subunit IIABC 466563 4065524 MGAS2096_Spy0488 Streptococcus pyogenes MGAS2096 PTS system beta-glucoside-specific transporter subunit IIABC YP_600084.1 464701 D 370565 CDS YP_600085.1 94991986 4065525 466582..468006 1 NC_008023.1 6-phospho-beta-glucosidase 468006 bglA 4065525 bglA Streptococcus pyogenes MGAS2096 6-phospho-beta-glucosidase YP_600085.1 466582 D 370565 CDS YP_600086.1 94991987 4065526 complement(468105..468944) 1 NC_008023.1 hypothetical protein 468944 4065526 MGAS2096_Spy0490 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600086.1 468105 R 370565 CDS YP_600087.1 94991988 4065527 complement(468920..469822) 1 NC_008023.1 hypothetical protein 469822 4065527 MGAS2096_Spy0491 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600087.1 468920 R 370565 CDS YP_600088.1 94991989 4065528 469956..470153 1 NC_008023.1 hypothetical protein 470153 4065528 MGAS2096_Spy0492 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600088.1 469956 D 370565 CDS YP_600089.1 94991990 4065529 470338..472491 1 NC_008023.1 S1 RNA binding domain; transcription accessory protein 472491 4065529 MGAS2096_Spy0493 Streptococcus pyogenes MGAS2096 transcription accessory protein YP_600089.1 470338 D 370565 CDS YP_600090.1 94991991 4065530 472433..472915 1 NC_008023.1 hypothetical protein 472915 4065530 MGAS2096_Spy0494 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600090.1 472433 D 370565 CDS YP_600091.1 94991992 4065531 472979..473251 1 NC_008023.1 stress-responsive transcriptional regulator PspC 473251 4065531 MGAS2096_Spy0495 Streptococcus pyogenes MGAS2096 stress-responsive transcriptional regulator PspC YP_600091.1 472979 D 370565 CDS YP_600092.2 162139136 4065532 473556..474548 1 NC_008023.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase 474548 ptsK 4065532 ptsK Streptococcus pyogenes MGAS2096 HPr kinase/phosphorylase YP_600092.2 473556 D 370565 CDS YP_600093.1 94991994 4065533 474545..475324 1 NC_008023.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 475324 lgt 4065533 lgt Streptococcus pyogenes MGAS2096 prolipoprotein diacylglyceryl transferase YP_600093.1 474545 D 370565 CDS YP_600094.1 94991995 4065534 475346..475753 1 NC_008023.1 hypothetical protein 475753 4065534 MGAS2096_Spy0498 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600094.1 475346 D 370565 CDS YP_600095.1 94991996 4065535 475725..476174 1 NC_008023.1 hypothetical protein 476174 4065535 MGAS2096_Spy0499 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600095.1 475725 D 370565 CDS YP_600096.1 94991997 4065536 complement(476334..476618) 1 NC_008023.1 hypothetical protein 476618 4065536 MGAS2096_Spy0500 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600096.1 476334 R 370565 CDS YP_600097.1 94991998 4065537 476817..477743 1 NC_008023.1 U32 family peptidase 477743 4065537 MGAS2096_Spy0501 Streptococcus pyogenes MGAS2096 U32 family peptidase YP_600097.1 476817 D 370565 CDS YP_600098.1 94991999 4065771 477845..479131 1 NC_008023.1 U32 family peptidase 479131 4065771 MGAS2096_Spy0502 Streptococcus pyogenes MGAS2096 U32 family peptidase YP_600098.1 477845 D 370565 CDS YP_600099.1 94992000 4065772 complement(479144..479272) 1 NC_008023.1 hypothetical protein 479272 4065772 MGAS2096_Spy0503 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600099.1 479144 R 370565 CDS YP_600100.1 94992001 4065773 479341..479553 1 NC_008023.1 putative cytoplasmic protein 479553 4065773 MGAS2096_Spy0504 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600100.1 479341 D 370565 CDS YP_600101.1 94992002 4065774 complement(479650..479790) 1 NC_008023.1 hypothetical protein 479790 4065774 MGAS2096_Spy0505 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600101.1 479650 R 370565 CDS YP_600102.1 94992003 4065775 complement(479926..481431) 1 NC_008023.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 481431 lysS 4065775 lysS Streptococcus pyogenes MGAS2096 lysyl-tRNA synthetase YP_600102.1 479926 R 370565 CDS YP_600103.1 94992004 4065776 481593..482495 1 NC_008023.1 haloacid dehalogenase-like hydrolase 482495 4065776 MGAS2096_Spy0507 Streptococcus pyogenes MGAS2096 haloacid dehalogenase-like hydrolase YP_600103.1 481593 D 370565 CDS YP_600104.1 94992005 4065777 complement(482603..483226) 1 NC_008023.1 phosphoglycerate mutase family protein 483226 4065777 MGAS2096_Spy0508 Streptococcus pyogenes MGAS2096 phosphoglycerate mutase family protein YP_600104.1 482603 R 370565 CDS YP_600105.1 94992006 4065778 complement(483567..484046) 1 NC_008023.1 transcriptional regulator 484046 4065778 MGAS2096_Spy0509 Streptococcus pyogenes MGAS2096 transcriptional regulator YP_600105.1 483567 R 370565 CDS YP_600106.1 94992007 4065779 complement(484137..484745) 1 NC_008023.1 thiamine transporter 484745 4065779 MGAS2096_Spy0510 Streptococcus pyogenes MGAS2096 thiamine transporter YP_600106.1 484137 R 370565 CDS YP_600107.1 94992008 4065780 complement(484969..485817) 1 NC_008023.1 N-acetylmuramoyl-L-alanine amidase 485817 4065780 MGAS2096_Spy0511 Streptococcus pyogenes MGAS2096 N-acetylmuramoyl-L-alanine amidase YP_600107.1 484969 R 370565 CDS YP_600108.1 94992009 4065781 486142..486645 1 NC_008023.1 integral membrane protein 486645 4065781 MGAS2096_Spy0512 Streptococcus pyogenes MGAS2096 integral membrane protein YP_600108.1 486142 D 370565 CDS YP_600109.1 94992010 4065782 486629..487012 1 NC_008023.1 hypothetical protein 487012 4065782 MGAS2096_Spy0513 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600109.1 486629 D 370565 CDS YP_600110.1 94992011 4065783 complement(487058..487582) 1 NC_008023.1 glutathione peroxidase 487582 4065783 MGAS2096_Spy0514 Streptococcus pyogenes MGAS2096 glutathione peroxidase YP_600110.1 487058 R 370565 CDS YP_600111.1 94992012 4065784 complement(487530..489404) 1 NC_008023.1 oligoendopeptidase F 489404 pepF 4065784 pepF Streptococcus pyogenes MGAS2096 oligoendopeptidase F YP_600111.1 487530 R 370565 CDS YP_600112.1 94992013 4065785 489473..492286 1 NC_008023.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 492286 ppc 4065785 ppc Streptococcus pyogenes MGAS2096 phosphoenolpyruvate carboxylase YP_600112.1 489473 D 370565 CDS YP_600113.1 94992014 4065786 492426..493730 1 NC_008023.1 cell division protein ftsW 493730 ftsW 4065786 ftsW Streptococcus pyogenes MGAS2096 cell division protein ftsW YP_600113.1 492426 D 370565 CDS YP_600114.1 94992015 4065787 complement(493747..493887) 1 NC_008023.1 putative cytoplasmic protein 493887 4065787 MGAS2096_Spy0518 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600114.1 493747 R 370565 CDS YP_600115.1 94992016 4065788 494033..494299 1 NC_008023.1 protein translation elongation factor Tu (EF-Tu) 494299 4065788 MGAS2096_Spy0519 Streptococcus pyogenes MGAS2096 protein translation elongation factor Tu (EF-Tu) YP_600115.1 494033 D 370565 CDS YP_600116.1 94992017 4065789 494244..495281 1 NC_008023.1 elongation factor Tu 495281 4065789 MGAS2096_Spy0520 Streptococcus pyogenes MGAS2096 elongation factor Tu YP_600116.1 494244 D 370565 CDS YP_600117.1 94992018 4065400 495522..496280 1 NC_008023.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 496280 tpiA 4065400 tpiA Streptococcus pyogenes MGAS2096 triosephosphate isomerase YP_600117.1 495522 D 370565 CDS YP_600118.1 94992019 4065401 complement(496379..497614) 1 NC_008023.1 factor essential for expression of methicillin resistance 497614 4065401 MGAS2096_Spy0522 Streptococcus pyogenes MGAS2096 factor essential for expression of methicillin resistance YP_600118.1 496379 R 370565 CDS YP_600119.1 94992020 4065402 complement(497601..498842) 1 NC_008023.1 bifunctional; UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase / UDP-N-acetylmuramoylpentapeptide-lysine N(6)-seryltransferase 498842 murM 4065402 murM Streptococcus pyogenes MGAS2096 UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase / UDP-N-acetylmuramoylpentapeptide-lysine N(6)-seryltransferase YP_600119.1 497601 R 370565 CDS YP_600120.1 94992021 4065403 complement(498827..499636) 1 NC_008023.1 HAD superfamily; hydrolase 499636 4065403 MGAS2096_Spy0524 Streptococcus pyogenes MGAS2096 hydrolase YP_600120.1 498827 R 370565 CDS YP_600121.1 94992022 4065404 complement(499787..500020) 1 NC_008023.1 putative cytoplasmic protein 500020 4065404 MGAS2096_Spy0525 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600121.1 499787 R 370565 CDS YP_600122.1 94992023 4065405 complement(500092..501495) 1 NC_008023.1 dGTP triphosphohydrolase 501495 4065405 MGAS2096_Spy0527 Streptococcus pyogenes MGAS2096 dGTP triphosphohydrolase YP_600122.1 500092 R 370565 CDS YP_600123.1 94992024 4065406 501476..501862 1 NC_008023.1 putative cytoplasmic protein 501862 4065406 MGAS2096_Spy0526 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600123.1 501476 D 370565 CDS YP_600124.1 94992025 4065407 502092..504773 1 NC_008023.1 calcium-transporting ATPase 504773 pacL 4065407 pacL Streptococcus pyogenes MGAS2096 calcium-transporting ATPase YP_600124.1 502092 D 370565 CDS YP_600125.1 94992026 4065408 complement(504857..505861) 1 NC_008023.1 LacI family transcriptional regulator 505861 regR 4065408 regR Streptococcus pyogenes MGAS2096 LacI family transcriptional regulator YP_600125.1 504857 R 370565 CDS YP_600126.1 94992027 4065409 complement(505916..507841) 1 NC_008023.1 oligohyaluronate lyase 507841 4065409 MGAS2096_Spy0530 Streptococcus pyogenes MGAS2096 oligohyaluronate lyase YP_600126.1 505916 R 370565 CDS YP_600127.1 94992028 4065410 complement(507910..508791) 1 NC_008023.1 PTS system N-acetylgalactosamine-specific transporter subunit IID 508791 agaD 4065410 agaD Streptococcus pyogenes MGAS2096 PTS system N-acetylgalactosamine-specific transporter subunit IID YP_600127.1 507910 R 370565 CDS YP_600128.1 94992029 4065411 complement(508718..509500) 1 NC_008023.1 PTS system N-acetylgalactosamine-specific transporter subunit IIC 509500 4065411 MGAS2096_Spy0532 Streptococcus pyogenes MGAS2096 PTS system N-acetylgalactosamine-specific transporter subunit IIC YP_600128.1 508718 R 370565 CDS YP_600129.1 94992030 4065412 complement(509519..510007) 1 NC_008023.1 PTS system N-acetylgalactosamine-specific transporter subunit IIB 510007 agaV 4065412 agaV Streptococcus pyogenes MGAS2096 PTS system N-acetylgalactosamine-specific transporter subunit IIB YP_600129.1 509519 R 370565 CDS YP_600130.1 94992031 4065413 complement(510043..511242) 1 NC_008023.1 unsaturated glucuronyl hydrolase 511242 4065413 MGAS2096_Spy0534 Streptococcus pyogenes MGAS2096 unsaturated glucuronyl hydrolase YP_600130.1 510043 R 370565 CDS YP_600131.1 94992032 4065414 complement(511242..511679) 1 NC_008023.1 PTS system N-acetylgalactosamine-specific transporter subunit IIA 511679 4065414 MGAS2096_Spy0535 Streptococcus pyogenes MGAS2096 PTS system N-acetylgalactosamine-specific transporter subunit IIA YP_600131.1 511242 R 370565 CDS YP_600132.1 94992033 4065415 512004..512798 1 NC_008023.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase 512798 idnO 4065415 idnO Streptococcus pyogenes MGAS2096 gluconate 5-dehydrogenase YP_600132.1 512004 D 370565 CDS YP_600133.1 94992034 4065416 512823..513464 1 NC_008023.1 hypothetical protein 513464 4065416 MGAS2096_Spy0537 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600133.1 512823 D 370565 CDS YP_600134.1 94992035 4065417 513454..514494 1 NC_008023.1 2-dehydro-3-deoxygluconokinase 514494 4065417 MGAS2096_Spy0538 Streptococcus pyogenes MGAS2096 2-dehydro-3-deoxygluconokinase YP_600134.1 513454 D 370565 CDS YP_600135.1 94992036 4065418 514481..515134 1 NC_008023.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 515134 kgdA 4065418 kgdA Streptococcus pyogenes MGAS2096 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase YP_600135.1 514481 D 370565 CDS YP_600136.1 94992037 4065419 515425..516081 1 NC_008023.1 bifunctional; Beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase 516081 4065419 MGAS2096_Spy0540 Streptococcus pyogenes MGAS2096 Beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase YP_600136.1 515425 D 370565 CDS YP_600137.1 94992038 4066241 516727..517902 1 NC_008023.1 iron-sulfur cluster-binding protein 517902 4066241 MGAS2096_Spy0541 Streptococcus pyogenes MGAS2096 iron-sulfur cluster-binding protein YP_600137.1 516727 D 370565 CDS YP_600138.1 94992039 4066242 518054..519067 1 NC_008023.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 519067 prfB 4066242 prfB Streptococcus pyogenes MGAS2096 peptide chain release factor 2 YP_600138.1 518054 D 370565 CDS YP_600139.1 94992040 4066243 519086..519778 1 NC_008023.1 cell division ATP-binding protein ftsE 519778 ftsE 4066243 ftsE Streptococcus pyogenes MGAS2096 cell division ATP-binding protein ftsE YP_600139.1 519086 D 370565 CDS YP_600140.1 94992041 4066244 519741..520700 1 NC_008023.1 cell division protein ftsX 520700 ftsX 4066244 ftsX Streptococcus pyogenes MGAS2096 cell division protein ftsX YP_600140.1 519741 D 370565 CDS YP_600141.1 94992042 4066245 complement(521009..521707) 1 NC_008023.1 hydroxyacylglutathione hydrolase 521707 4066245 MGAS2096_Spy0545 Streptococcus pyogenes MGAS2096 hydroxyacylglutathione hydrolase YP_600141.1 521009 R 370565 CDS YP_600142.1 94992043 4066246 521848..522639 1 NC_008023.1 bifunctional; acetoin reductase 522639 4066246 MGAS2096_Spy0546 Streptococcus pyogenes MGAS2096 acetoin reductase YP_600142.1 521848 D 370565 CDS YP_600143.1 94992044 4066247 522747..525248 1 NC_008023.1 unwinds DNA; bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon 525248 dinG 4066247 dinG Streptococcus pyogenes MGAS2096 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon YP_600143.1 522747 D 370565 CDS YP_600144.1 94992045 4066248 525583..526776 1 NC_008023.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 526776 aspC 4066248 aspC Streptococcus pyogenes MGAS2096 aspartate aminotransferase YP_600144.1 525583 D 370565 CDS YP_600145.1 94992046 4066249 526797..528143 1 NC_008023.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 528143 asnC 4066249 asnC Streptococcus pyogenes MGAS2096 asparaginyl-tRNA synthetase YP_600145.1 526797 D 370565 CDS YP_600146.1 94992047 4066250 528558..529448 1 NC_008023.1 contains P-loop; hypothetical protein 529448 4066250 MGAS2096_Spy0550 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600146.1 528558 D 370565 CDS YP_600147.1 94992048 4066251 529445..530422 1 NC_008023.1 hypothetical protein 530422 4066251 MGAS2096_Spy0551 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600147.1 529445 D 370565 CDS YP_600148.1 94992049 4066252 530419..531330 1 NC_008023.1 putative cytoplasmic protein 531330 4066252 MGAS2096_Spy0552 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600148.1 530419 D 370565 CDS YP_600149.1 94992050 4066253 complement(531507..532922) 1 NC_008023.1 site-specific recombinase 532922 4066253 MGAS2096_Spy0553 Streptococcus pyogenes MGAS2096 site-specific recombinase YP_600149.1 531507 R 370565 CDS YP_600150.1 94992051 4066254 complement(533043..533408) 1 NC_008023.1 phage protein 533408 4066254 MGAS2096_Spy0554 Streptococcus pyogenes MGAS2096 phage protein YP_600150.1 533043 R 370565 CDS YP_600151.1 94992052 4066255 complement(533435..534196) 1 NC_008023.1 phage transcriptional repressor 534196 4066255 MGAS2096_Spy0555 Streptococcus pyogenes MGAS2096 phage transcriptional repressor YP_600151.1 533435 R 370565 CDS YP_600152.1 94992053 4066256 534380..534610 1 NC_008023.1 Cro family transcriptional regulator 534610 4066256 MGAS2096_Spy0556 Streptococcus pyogenes MGAS2096 Cro family transcriptional regulator YP_600152.1 534380 D 370565 CDS YP_600153.1 94992054 4066257 534679..534816 1 NC_008023.1 phage protein 534816 4066257 MGAS2096_Spy0557 Streptococcus pyogenes MGAS2096 phage protein YP_600153.1 534679 D 370565 CDS YP_600154.1 94992055 4066258 534818..534943 1 NC_008023.1 phage protein 534943 4066258 MGAS2096_Spy0558 Streptococcus pyogenes MGAS2096 phage protein YP_600154.1 534818 D 370565 CDS YP_600155.1 94992056 4066259 534940..535167 1 NC_008023.1 phage protein 535167 4066259 MGAS2096_Spy0559 Streptococcus pyogenes MGAS2096 phage protein YP_600155.1 534940 D 370565 CDS YP_600156.1 94992057 4064654 535146..536486 1 NC_008023.1 chromosome segregation ATPases 536486 4064654 MGAS2096_Spy0560 Streptococcus pyogenes MGAS2096 chromosome segregation ATPases YP_600156.1 535146 D 370565 CDS YP_600157.1 94992058 4064655 536501..537592 1 NC_008023.1 phage protein 537592 4064655 MGAS2096_Spy0561 Streptococcus pyogenes MGAS2096 phage protein YP_600157.1 536501 D 370565 CDS YP_600158.1 94992059 4064656 537632..538054 1 NC_008023.1 phage protein 538054 4064656 MGAS2096_Spy0562 Streptococcus pyogenes MGAS2096 phage protein YP_600158.1 537632 D 370565 CDS YP_600159.1 94992060 4064657 538056..538790 1 NC_008023.1 phage protein 538790 4064657 MGAS2096_Spy0563 Streptococcus pyogenes MGAS2096 phage protein YP_600159.1 538056 D 370565 CDS YP_600160.1 94992061 4064658 538812..539447 1 NC_008023.1 phage protein 539447 4064658 MGAS2096_Spy0564 Streptococcus pyogenes MGAS2096 phage protein YP_600160.1 538812 D 370565 CDS YP_600161.1 94992062 4064659 539432..541030 1 NC_008023.1 DEAD/DEAH box family; DNA/RNA helicase 541030 4064659 MGAS2096_Spy0565 Streptococcus pyogenes MGAS2096 DNA/RNA helicase YP_600161.1 539432 D 370565 CDS YP_600162.1 94992063 4064660 541040..541669 1 NC_008023.1 hypothetical protein 541669 4064660 MGAS2096_Spy0566 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600162.1 541040 D 370565 CDS YP_600163.1 94992064 4064661 541659..543932 1 NC_008023.1 ATPase 543932 4064661 MGAS2096_Spy0567 Streptococcus pyogenes MGAS2096 ATPase YP_600163.1 541659 D 370565 CDS YP_600164.1 94992065 4064662 544210..544428 1 NC_008023.1 phage protein 544428 4064662 MGAS2096_Spy0568 Streptococcus pyogenes MGAS2096 phage protein YP_600164.1 544210 D 370565 CDS YP_600165.1 94992066 4064663 544403..544816 1 NC_008023.1 phage protein 544816 4064663 MGAS2096_Spy0569 Streptococcus pyogenes MGAS2096 phage protein YP_600165.1 544403 D 370565 CDS YP_600166.1 94992067 4064664 544813..545034 1 NC_008023.1 hypothetical protein 545034 4064664 MGAS2096_Spy0570 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600166.1 544813 D 370565 CDS YP_600167.1 94992068 4064665 545037..545309 1 NC_008023.1 phage protein 545309 4064665 MGAS2096_Spy0571 Streptococcus pyogenes MGAS2096 phage protein YP_600167.1 545037 D 370565 CDS YP_600168.1 94992069 4064666 545245..545946 1 NC_008023.1 phage protein 545946 4064666 MGAS2096_Spy0572 Streptococcus pyogenes MGAS2096 phage protein YP_600168.1 545245 D 370565 CDS YP_600169.1 94992070 4064667 546219..546653 1 NC_008023.1 ArpU family phage encoded transcriptional regulator 546653 4064667 MGAS2096_Spy0573 Streptococcus pyogenes MGAS2096 ArpU family phage encoded transcriptional regulator YP_600169.1 546219 D 370565 CDS YP_600170.1 94992071 4064668 546963..548129 1 NC_008023.1 chromosome partitioning protein parB / adenine-specific methyltransferase 548129 4064668 MGAS2096_Spy0574 Streptococcus pyogenes MGAS2096 chromosome partitioning protein parB / adenine-specific methyltransferase YP_600170.1 546963 D 370565 CDS YP_600171.1 94992072 4064669 548472..548948 1 NC_008023.1 phage protein 548948 4064669 MGAS2096_Spy0575 Streptococcus pyogenes MGAS2096 phage protein YP_600171.1 548472 D 370565 CDS YP_600172.1 94992073 4064670 549031..550242 1 NC_008023.1 terminase large subunit 550242 4064670 MGAS2096_Spy0576 Streptococcus pyogenes MGAS2096 terminase large subunit YP_600172.1 549031 D 370565 CDS YP_600173.1 94992074 4064671 550256..551758 1 NC_008023.1 minor capsid protein 551758 4064671 MGAS2096_Spy0577 Streptococcus pyogenes MGAS2096 minor capsid protein YP_600173.1 550256 D 370565 CDS YP_600174.1 94992075 4064672 551763..553256 1 NC_008023.1 minor capsid protein 553256 4064672 MGAS2096_Spy0578 Streptococcus pyogenes MGAS2096 minor capsid protein YP_600174.1 551763 D 370565 CDS YP_600175.1 94992076 4064673 553253..553483 1 NC_008023.1 phage protein 553483 4064673 MGAS2096_Spy0579 Streptococcus pyogenes MGAS2096 phage protein YP_600175.1 553253 D 370565 CDS YP_600176.1 94992077 4065176 553570..553836 1 NC_008023.1 phage protein 553836 4065176 MGAS2096_Spy0580 Streptococcus pyogenes MGAS2096 phage protein YP_600176.1 553570 D 370565 CDS YP_600177.1 94992078 4065177 553962..554576 1 NC_008023.1 phage protein 554576 4065177 MGAS2096_Spy0581 Streptococcus pyogenes MGAS2096 phage protein YP_600177.1 553962 D 370565 CDS YP_600178.1 94992079 4065178 554580..555398 1 NC_008023.1 major head protein 555398 4065178 MGAS2096_Spy0582 Streptococcus pyogenes MGAS2096 major head protein YP_600178.1 554580 D 370565 CDS YP_600179.1 94992080 4065179 555452..555868 1 NC_008023.1 phage protein 555868 4065179 MGAS2096_Spy0583 Streptococcus pyogenes MGAS2096 phage protein YP_600179.1 555452 D 370565 CDS YP_600180.1 94992081 4065180 555831..556190 1 NC_008023.1 minor capsid protein 556190 4065180 MGAS2096_Spy0584 Streptococcus pyogenes MGAS2096 minor capsid protein YP_600180.1 555831 D 370565 CDS YP_600181.1 94992082 4065181 556190..556546 1 NC_008023.1 minor capsid protein 556546 4065181 MGAS2096_Spy0585 Streptococcus pyogenes MGAS2096 minor capsid protein YP_600181.1 556190 D 370565 CDS YP_600182.1 94992083 4065182 556543..556941 1 NC_008023.1 minor capsid protein 556941 4065182 MGAS2096_Spy0586 Streptococcus pyogenes MGAS2096 minor capsid protein YP_600182.1 556543 D 370565 CDS YP_600183.1 94992084 4065183 556941..557411 1 NC_008023.1 major tail shaft protein 557411 4065183 MGAS2096_Spy0587 Streptococcus pyogenes MGAS2096 major tail shaft protein YP_600183.1 556941 D 370565 CDS YP_600184.1 94992085 4065184 557464..557898 1 NC_008023.1 phage protein 557898 4065184 MGAS2096_Spy0588 Streptococcus pyogenes MGAS2096 phage protein YP_600184.1 557464 D 370565 CDS YP_600185.1 94992086 4065185 557902..558483 1 NC_008023.1 phage protein 558483 4065185 MGAS2096_Spy0589 Streptococcus pyogenes MGAS2096 phage protein YP_600185.1 557902 D 370565 CDS YP_600186.1 94992087 4065186 558452..561733 1 NC_008023.1 phage protein 561733 4065186 MGAS2096_Spy0590 Streptococcus pyogenes MGAS2096 phage protein YP_600186.1 558452 D 370565 CDS YP_600187.1 94992088 4065187 561730..562446 1 NC_008023.1 phage protein 562446 4065187 MGAS2096_Spy0591 Streptococcus pyogenes MGAS2096 phage protein YP_600187.1 561730 D 370565 CDS YP_600188.1 94992089 4065188 562443..564590 1 NC_008023.1 phage endopeptidase 564590 4065188 MGAS2096_Spy0592 Streptococcus pyogenes MGAS2096 phage endopeptidase YP_600188.1 562443 D 370565 CDS YP_600189.1 94992090 4065189 564587..565642 1 NC_008023.1 hyaluronoglucosaminidase 565642 4065189 MGAS2096_Spy0593 Streptococcus pyogenes MGAS2096 hyaluronoglucosaminidase YP_600189.1 564587 D 370565 CDS YP_600190.1 94992091 4065190 565642..566277 1 NC_008023.1 phage protein 566277 4065190 MGAS2096_Spy0594 Streptococcus pyogenes MGAS2096 phage protein YP_600190.1 565642 D 370565 CDS YP_600191.1 94992092 4065191 566288..568195 1 NC_008023.1 phage infection protein 568195 4065191 MGAS2096_Spy0595 Streptococcus pyogenes MGAS2096 phage infection protein YP_600191.1 566288 D 370565 CDS YP_600192.1 94992093 4065192 568204..568365 1 NC_008023.1 phage protein 568365 4065192 MGAS2096_Spy0596 Streptococcus pyogenes MGAS2096 phage protein YP_600192.1 568204 D 370565 CDS YP_600193.1 94992094 4065193 568368..568988 1 NC_008023.1 phage protein 568988 4065193 MGAS2096_Spy0597 Streptococcus pyogenes MGAS2096 phage protein YP_600193.1 568368 D 370565 CDS YP_600194.1 94992095 4065194 568999..569298 1 NC_008023.1 phage protein 569298 4065194 MGAS2096_Spy0598 Streptococcus pyogenes MGAS2096 phage protein YP_600194.1 568999 D 370565 CDS YP_600195.1 94992096 4064825 569295..569480 1 NC_008023.1 phage protein 569480 4064825 MGAS2096_Spy0599 Streptococcus pyogenes MGAS2096 phage protein YP_600195.1 569295 D 370565 CDS YP_600196.1 94992097 4064826 569591..570787 1 NC_008023.1 phage-associated cell wall hydrolase 570787 4064826 MGAS2096_Spy0600 Streptococcus pyogenes MGAS2096 phage-associated cell wall hydrolase YP_600196.1 569591 D 370565 CDS YP_600197.1 94992098 4064827 complement(570855..571562) 1 NC_008023.1 enterotoxin 571562 speA2 4064827 speA2 Streptococcus pyogenes MGAS2096 enterotoxin YP_600197.1 570855 R 370565 CDS YP_600198.1 94992099 4064828 complement(571673..572431) 1 NC_008023.1 streptodornase 572431 spd3 4064828 spd3 Streptococcus pyogenes MGAS2096 streptodornase YP_600198.1 571673 R 370565 CDS YP_600199.1 94992100 4064829 572743..574161 1 NC_008023.1 dipeptidase A 574161 pepD 4064829 pepD Streptococcus pyogenes MGAS2096 dipeptidase A YP_600199.1 572743 D 370565 CDS YP_600200.1 94992101 4064830 574313..575860 1 NC_008023.1 high-affinity zinc uptake system protein ZnuA 575860 4064830 MGAS2096_Spy0604 Streptococcus pyogenes MGAS2096 high-affinity zinc uptake system protein ZnuA YP_600200.1 574313 D 370565 CDS YP_600201.1 94992102 4064831 575999..576730 1 NC_008023.1 GntR family transcriptional regulator 576730 4064831 MGAS2096_Spy0605 Streptococcus pyogenes MGAS2096 GntR family transcriptional regulator YP_600201.1 575999 D 370565 CDS YP_600202.1 94992103 4064832 576750..577949 1 NC_008023.1 galactosamine-6-phosphate deaminase 577949 agaS 4064832 agaS Streptococcus pyogenes MGAS2096 galactosamine-6-phosphate deaminase YP_600202.1 576750 D 370565 CDS YP_600203.1 94992104 4064833 complement(578046..578306) 1 NC_008023.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 578306 rpmE2 4064833 rpmE2 Streptococcus pyogenes MGAS2096 50S ribosomal protein L31 YP_600203.1 578046 R 370565 CDS YP_600204.1 94992105 4064834 complement(578421..579254) 1 NC_008023.1 phosphoesterase, DHH family protein 579254 4064834 MGAS2096_Spy0608 Streptococcus pyogenes MGAS2096 phosphoesterase, DHH family protein YP_600204.1 578421 R 370565 CDS YP_600205.1 94992106 4064835 579741..580202 1 NC_008023.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 580202 4064835 MGAS2096_Spy0609 Streptococcus pyogenes MGAS2096 flavodoxin YP_600205.1 579741 D 370565 CDS YP_600206.1 94992107 4064836 580377..580661 1 NC_008023.1 hypothetical protein 580661 4064836 MGAS2096_Spy0610 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600206.1 580377 D 370565 CDS YP_600207.1 94992108 4064837 580642..581916 1 NC_008023.1 chloride channel protein 581916 4064837 MGAS2096_Spy0611 Streptococcus pyogenes MGAS2096 chloride channel protein YP_600207.1 580642 D 370565 CDS YP_600208.1 94992109 4064838 582031..582378 1 NC_008023.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 582378 rplS 4064838 rplS Streptococcus pyogenes MGAS2096 50S ribosomal protein L19 YP_600208.1 582031 D 370565 CDS YP_600209.1 94992110 4064840 complement(582739..582954) 1 NC_008023.1 DNA integration/recombination/inversion protein 582954 int2 4064840 int2 Streptococcus pyogenes MGAS2096 DNA integration/recombination/inversion protein YP_600209.1 582739 R 370565 CDS YP_600210.1 94992111 4064841 583392..583961 1 NC_008023.1 phosphatase 583961 4064841 MGAS2096_Spy0614 Streptococcus pyogenes MGAS2096 phosphatase YP_600210.1 583392 D 370565 CDS YP_600211.1 94992112 4064842 583962..585917 1 NC_008023.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 585917 gyrB 4064842 gyrB Streptococcus pyogenes MGAS2096 DNA gyrase subunit B YP_600211.1 583962 D 370565 CDS YP_600212.1 94992113 4064843 586309..588033 1 NC_008023.1 acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation; septation ring formation regulator EzrA 588033 4064843 MGAS2096_Spy0616 Streptococcus pyogenes MGAS2096 septation ring formation regulator EzrA YP_600212.1 586309 D 370565 CDS YP_600213.1 94992114 4066157 complement(588165..588623) 1 NC_008023.1 putative cytoplasmic protein 588623 4066157 MGAS2096_Spy0617 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600213.1 588165 R 370565 CDS YP_600214.1 94992115 4066158 588856..590163 1 NC_008023.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 590163 eno 4066158 eno Streptococcus pyogenes MGAS2096 phosphopyruvate hydratase YP_600214.1 588856 D 370565 CDS YP_600215.1 94992116 4066159 complement(590752..591327) 1 NC_008023.1 transposase 591327 4066159 MGAS2096_Spy0619 Streptococcus pyogenes MGAS2096 transposase YP_600215.1 590752 R 370565 CDS YP_600216.1 94992117 4066160 complement(591413..591574) 1 NC_008023.1 transposase 591574 4066160 MGAS2096_Spy0620 Streptococcus pyogenes MGAS2096 transposase YP_600216.1 591413 R 370565 CDS YP_600217.1 94992118 4066161 complement(591936..592484) 1 NC_008023.1 transcriptional regulator 592484 4066161 MGAS2096_Spy0621 Streptococcus pyogenes MGAS2096 transcriptional regulator YP_600217.1 591936 R 370565 CDS YP_600218.1 94992119 4066162 592529..597796 1 NC_008023.1 extracellular matrix binding protein 597796 epf 4066162 epf Streptococcus pyogenes MGAS2096 extracellular matrix binding protein YP_600218.1 592529 D 370565 CDS YP_600219.1 94992120 4066163 598660..598821 1 NC_008023.1 streptolysin S 598821 sagA 4066163 sagA Streptococcus pyogenes MGAS2096 streptolysin S YP_600219.1 598660 D 370565 CDS YP_600220.1 94992121 4066164 599043..599993 1 NC_008023.1 streptolysin S biosynthesis protein SagB 599993 sagB 4066164 sagB Streptococcus pyogenes MGAS2096 streptolysin S biosynthesis protein SagB YP_600220.1 599043 D 370565 CDS YP_600221.1 94992122 4066165 599990..601048 1 NC_008023.1 streptolysin S biosynthesis protein SagC 601048 sagC 4066165 sagC Streptococcus pyogenes MGAS2096 streptolysin S biosynthesis protein SagC YP_600221.1 599990 D 370565 CDS YP_600222.1 94992123 4066166 601068..602426 1 NC_008023.1 streptolysin S biosynthesis protein SagD 602426 sagD 4066166 sagD Streptococcus pyogenes MGAS2096 streptolysin S biosynthesis protein SagD YP_600222.1 601068 D 370565 CDS YP_600223.1 94992124 4066167 602401..603072 1 NC_008023.1 streptolysin S putative self-immunity protein SagE 603072 sagE 4066167 sagE Streptococcus pyogenes MGAS2096 streptolysin S putative self-immunity protein SagE YP_600223.1 602401 D 370565 CDS YP_600224.1 94992125 4066168 603069..603752 1 NC_008023.1 streptolysin S biosynthesis protein SagF 603752 sagF 4066168 sagF Streptococcus pyogenes MGAS2096 streptolysin S biosynthesis protein SagF YP_600224.1 603069 D 370565 CDS YP_600225.1 94992126 4066169 603775..604698 1 NC_008023.1 streptolysin S export ATP-binding protein SagG 604698 sagG 4066169 sagG Streptococcus pyogenes MGAS2096 streptolysin S export ATP-binding protein SagG YP_600225.1 603775 D 370565 CDS YP_600226.1 94992127 4066170 604707..605834 1 NC_008023.1 streptolysin S export transmembrane protein SagH 605834 sagH 4066170 sagH Streptococcus pyogenes MGAS2096 streptolysin S export transmembrane protein SagH YP_600226.1 604707 D 370565 CDS YP_600227.1 94992128 4066171 605831..606949 1 NC_008023.1 streptolysin S export transmembrane protein SagI 606949 sagI 4066171 sagI Streptococcus pyogenes MGAS2096 streptolysin S export transmembrane protein SagI YP_600227.1 605831 D 370565 CDS YP_600228.1 94992129 4066172 complement(607060..607287) 1 NC_008023.1 hypothetical protein 607287 4066172 MGAS2096_Spy0632 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600228.1 607060 R 370565 CDS YP_600229.1 94992130 4066173 607529..610261 1 NC_008023.1 endonuclease/exonuclease/phosphatase family protein 610261 4066173 MGAS2096_Spy0633 Streptococcus pyogenes MGAS2096 endonuclease/exonuclease/phosphatase family protein YP_600229.1 607529 D 370565 CDS YP_600230.1 94992131 4066174 610539..611039 1 NC_008023.1 hypothetical protein 611039 4066174 MGAS2096_Spy0634 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600230.1 610539 D 370565 CDS YP_600231.1 94992132 4066175 611233..613191 1 NC_008023.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 613191 ligA 4066175 ligA Streptococcus pyogenes MGAS2096 NAD-dependent DNA ligase LigA YP_600231.1 611233 D 370565 CDS YP_600232.1 94992133 4064771 613205..614227 1 NC_008023.1 similar to YegS from E. coli; putative lipid kinase 614227 4064771 MGAS2096_Spy0636 Streptococcus pyogenes MGAS2096 putative lipid kinase YP_600232.1 613205 D 370565 CDS YP_600233.1 94992134 4064772 614619..614816 1 NC_008023.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 614816 atpE 4064772 atpE Streptococcus pyogenes MGAS2096 F0F1 ATP synthase subunit C YP_600233.1 614619 D 370565 CDS YP_600234.1 94992135 4064773 614851..615567 1 NC_008023.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 615567 atpB 4064773 atpB Streptococcus pyogenes MGAS2096 F0F1 ATP synthase subunit A YP_600234.1 614851 D 370565 CDS YP_600235.1 94992136 4064774 615585..616079 1 NC_008023.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 616079 atpF 4064774 atpF Streptococcus pyogenes MGAS2096 F0F1 ATP synthase subunit B YP_600235.1 615585 D 370565 CDS YP_600236.1 94992137 4064775 616079..616615 1 NC_008023.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 616615 atpH 4064775 atpH Streptococcus pyogenes MGAS2096 F0F1 ATP synthase subunit delta YP_600236.1 616079 D 370565 CDS YP_600237.1 94992138 4064776 616631..618139 1 NC_008023.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 618139 atpA 4064776 atpA Streptococcus pyogenes MGAS2096 F0F1 ATP synthase subunit alpha YP_600237.1 616631 D 370565 CDS YP_600238.1 94992139 4064777 618155..619030 1 NC_008023.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 619030 atpG 4064777 atpG Streptococcus pyogenes MGAS2096 F0F1 ATP synthase subunit gamma YP_600238.1 618155 D 370565 CDS YP_600239.1 94992140 4064778 619192..620598 1 NC_008023.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 620598 atpD 4064778 atpD Streptococcus pyogenes MGAS2096 F0F1 ATP synthase subunit beta YP_600239.1 619192 D 370565 CDS YP_600240.1 94992141 4064779 620611..621027 1 NC_008023.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 621027 atpC 4064779 atpC Streptococcus pyogenes MGAS2096 F0F1 ATP synthase subunit epsilon YP_600240.1 620611 D 370565 CDS YP_600241.1 94992142 4064780 621293..621550 1 NC_008023.1 hypothetical protein 621550 4064780 MGAS2096_Spy0645 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600241.1 621293 D 370565 CDS YP_600242.1 94992143 4064781 621615..622886 1 NC_008023.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 622886 murA 4064781 murA Streptococcus pyogenes MGAS2096 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_600242.1 621615 D 370565 CDS YP_600243.1 94992144 4064782 622890..623078 1 NC_008023.1 EpuA protein 623078 epuA 4064782 epuA Streptococcus pyogenes MGAS2096 EpuA protein YP_600243.1 622890 D 370565 CDS YP_600244.1 94992145 4064783 623114..623653 1 NC_008023.1 DNA-entry nuclease 623653 endA 4064783 endA Streptococcus pyogenes MGAS2096 DNA-entry nuclease YP_600244.1 623114 D 370565 CDS YP_600245.2 162139135 4064784 623936..624979 1 NC_008023.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 624979 pheS 4064784 pheS Streptococcus pyogenes MGAS2096 phenylalanyl-tRNA synthetase subunit alpha YP_600245.2 623936 D 370565 CDS YP_600246.1 94992147 4064785 625174..627594 1 NC_008023.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 627594 pheT 4064785 pheT Streptococcus pyogenes MGAS2096 phenylalanyl-tRNA synthetase subunit beta YP_600246.1 625174 D 370565 CDS YP_600247.1 94992148 4064786 627668..628081 1 NC_008023.1 Salt-stress induced protein 628081 4064786 MGAS2096_Spy0651 Streptococcus pyogenes MGAS2096 Salt-stress induced protein YP_600247.1 627668 D 370565 CDS YP_600248.1 94992149 4064787 628074..628460 1 NC_008023.1 hypothetical protein 628460 4064787 MGAS2096_Spy0652 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600248.1 628074 D 370565 CDS YP_600249.1 94992150 4064788 628533..629195 1 NC_008023.1 ABC transporter permease 629195 4064788 MGAS2096_Spy0653 Streptococcus pyogenes MGAS2096 ABC transporter permease YP_600249.1 628533 D 370565 CDS YP_600250.1 94992151 4064789 629305..629607 1 NC_008023.1 ABC transporter permease 629607 4064789 MGAS2096_Spy0654 Streptococcus pyogenes MGAS2096 ABC transporter permease YP_600250.1 629305 D 370565 CDS YP_600251.1 94992152 4064790 629614..630285 1 NC_008023.1 ABC transporter ATP-binding protein 630285 4064790 MGAS2096_Spy0655 Streptococcus pyogenes MGAS2096 ABC transporter ATP-binding protein YP_600251.1 629614 D 370565 CDS YP_600252.1 94992153 4064538 complement(630389..631306) 1 NC_008023.1 neutral zinc metallopeptidase family protein 631306 4064538 MGAS2096_Spy0656 Streptococcus pyogenes MGAS2096 neutral zinc metallopeptidase family protein YP_600252.1 630389 R 370565 CDS YP_600253.1 94992154 4064539 631457..634672 1 NC_008023.1 ATP-dependent nuclease subunit B 634672 rexB 4064539 rexB Streptococcus pyogenes MGAS2096 ATP-dependent nuclease subunit B YP_600253.1 631457 D 370565 CDS YP_600254.1 94992155 4064540 634633..637224 1 NC_008023.1 ATP-dependent nuclease subunit A 637224 rexA 4064540 rexA Streptococcus pyogenes MGAS2096 ATP-dependent nuclease subunit A YP_600254.1 634633 D 370565 CDS YP_600255.1 94992156 4064541 637227..638300 1 NC_008023.1 ATP-dependent nuclease subunit A 638300 4064541 MGAS2096_Spy0659 Streptococcus pyogenes MGAS2096 ATP-dependent nuclease subunit A YP_600255.1 637227 D 370565 CDS YP_600256.1 94992157 4064542 638416..639252 1 NC_008023.1 arginine-binding protein 639252 4064542 MGAS2096_Spy0660 Streptococcus pyogenes MGAS2096 arginine-binding protein YP_600256.1 638416 D 370565 CDS YP_600257.2 162139134 4064543 639393..639569 1 NC_008023.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 639569 rpsU 4064543 rpsU Streptococcus pyogenes MGAS2096 30S ribosomal protein S21 YP_600257.2 639393 D 370565 CDS YP_600258.1 94992159 4064544 complement(639697..640059) 1 NC_008023.1 large-conductance mechanosensitive channel 640059 mscL 4064544 mscL Streptococcus pyogenes MGAS2096 large-conductance mechanosensitive channel YP_600258.1 639697 R 370565 CDS YP_600259.1 94992160 4064545 640189..642003 1 NC_008023.1 synthesizes RNA primers at the replication forks; DNA primase 642003 dnaG 4064545 dnaG Streptococcus pyogenes MGAS2096 DNA primase YP_600259.1 640189 D 370565 CDS YP_600260.1 94992161 4064546 642012..643121 1 NC_008023.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium; RNA polymerase sigma factor RpoD 643121 rpoD 4064546 rpoD Streptococcus pyogenes MGAS2096 RNA polymerase sigma factor RpoD YP_600260.1 642012 D 370565 CDS YP_600261.1 94992162 4064547 643357..643695 1 NC_008023.1 putative cytoplasmic protein 643695 4064547 MGAS2096_Spy0665 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600261.1 643357 D 370565 CDS YP_600262.1 94992163 4064548 643773..644687 1 NC_008023.1 dTDP-4-dehydrorhamnose reductase 644687 rmlD 4064548 rmlD Streptococcus pyogenes MGAS2096 dTDP-4-dehydrorhamnose reductase YP_600262.1 643773 D 370565 CDS YP_600263.1 94992164 4064549 644639..644758 1 NC_008023.1 hypothetical protein 644758 4064549 MGAS2096_Spy0667 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600263.1 644639 D 370565 CDS YP_600264.1 94992165 4064550 644806..645960 1 NC_008023.1 alpha-D-GlcNAc alpha-1,2-L-rhamnosyltransferase 645960 rgpAc 4064550 rgpAc Streptococcus pyogenes MGAS2096 alpha-D-GlcNAc alpha-1,2-L-rhamnosyltransferase YP_600264.1 644806 D 370565 CDS YP_600265.1 94992166 4064551 645950..646882 1 NC_008023.1 alpha-L-Rha alpha-1,3-L-rhamnosyltransferase 646882 rgpBc 4064551 rgpBc Streptococcus pyogenes MGAS2096 alpha-L-Rha alpha-1,3-L-rhamnosyltransferase YP_600265.1 645950 D 370565 CDS YP_600266.1 94992167 4064552 646885..647688 1 NC_008023.1 polysaccharide ABC transporter permease 647688 rgpCc 4064552 rgpCc Streptococcus pyogenes MGAS2096 polysaccharide ABC transporter permease YP_600266.1 646885 D 370565 CDS YP_600267.1 94992168 4064553 647688..648893 1 NC_008023.1 polysaccharide export ATP-binding protein 648893 rgpDc 4064553 rgpDc Streptococcus pyogenes MGAS2096 polysaccharide export ATP-binding protein YP_600267.1 647688 D 370565 CDS YP_600268.1 94992169 4064554 648918..649925 1 NC_008023.1 glycosyltransferase 649925 rgpEc 4064554 rgpEc Streptococcus pyogenes MGAS2096 glycosyltransferase YP_600268.1 648918 D 370565 CDS YP_600269.1 94992170 4064555 649922..651667 1 NC_008023.1 bifunctional; alpha-L-Rha alpha-1,2-L-rhamnosyltransferase / alpha-L-Rha alpha-1,3-L-rhamnosyltransferase 651667 rgpFc 4064555 rgpFc Streptococcus pyogenes MGAS2096 alpha-L-Rha alpha-1,2-L-rhamnosyltransferase / alpha-L-Rha alpha-1,3-L-rhamnosyltransferase YP_600269.1 649922 D 370565 CDS YP_600270.1 94992171 4064556 651664..654138 1 NC_008023.1 phosphoglycerol transferase 654138 4064556 MGAS2096_Spy0674 Streptococcus pyogenes MGAS2096 phosphoglycerol transferase YP_600270.1 651664 D 370565 CDS YP_600271.1 94992172 4064903 654317..655012 1 NC_008023.1 cell wall biosynthesis glycosyltransferase 655012 4064903 MGAS2096_Spy0675 Streptococcus pyogenes MGAS2096 cell wall biosynthesis glycosyltransferase YP_600271.1 654317 D 370565 CDS YP_600272.1 94992173 4064904 655014..655355 1 NC_008023.1 hypothetical protein 655355 4064904 MGAS2096_Spy0676 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600272.1 655014 D 370565 CDS YP_600273.1 94992174 4064905 655348..656634 1 NC_008023.1 transcriptional activator amrA 656634 amrA 4064905 amrA Streptococcus pyogenes MGAS2096 transcriptional activator amrA YP_600273.1 655348 D 370565 CDS YP_600274.1 94992175 4064906 656615..658111 1 NC_008023.1 hypothetical protein 658111 4064906 MGAS2096_Spy0678 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600274.1 656615 D 370565 CDS YP_600275.1 94992176 4064907 658193..659428 1 NC_008023.1 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 659428 pepT 4064907 pepT Streptococcus pyogenes MGAS2096 peptidase T YP_600275.1 658193 D 370565 CDS YP_600276.1 94992177 4064908 659469..659957 1 NC_008023.1 pore forming protein ebsA 659957 ebsA 4064908 ebsA Streptococcus pyogenes MGAS2096 pore forming protein ebsA YP_600276.1 659469 D 370565 CDS YP_600277.1 94992178 4064909 complement(659944..660141) 1 NC_008023.1 ferredoxin 660141 4064909 MGAS2096_Spy0681 Streptococcus pyogenes MGAS2096 ferredoxin YP_600277.1 659944 R 370565 CDS YP_600278.1 94992179 4064910 660190..660666 1 NC_008023.1 hypothetical protein 660666 4064910 MGAS2096_Spy0682 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600278.1 660190 D 370565 CDS YP_600279.1 94992180 4064911 660681..661361 1 NC_008023.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 661361 cmk 4064911 cmk Streptococcus pyogenes MGAS2096 cytidylate kinase YP_600279.1 660681 D 370565 CDS YP_600280.1 94992181 4064912 661523..662053 1 NC_008023.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 662053 infC 4064912 infC Streptococcus pyogenes MGAS2096 translation initiation factor IF-3 YP_600280.1 661523 D 370565 CDS YP_600281.1 94992182 4064913 662095..662292 1 NC_008023.1 50S ribosomal protein L35 662292 rpmI 4064913 rpmI Streptococcus pyogenes MGAS2096 50S ribosomal protein L35 YP_600281.1 662095 D 370565 CDS YP_600282.1 94992183 4064914 662351..662710 1 NC_008023.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 662710 rplT 4064914 rplT Streptococcus pyogenes MGAS2096 50S ribosomal protein L20 YP_600282.1 662351 D 370565 CDS YP_600283.1 94992184 4064915 complement(663001..665217) 1 NC_008023.1 sulfatase family protein 665217 4064915 MGAS2096_Spy0687 Streptococcus pyogenes MGAS2096 sulfatase family protein YP_600283.1 663001 R 370565 CDS YP_600284.1 94992185 4064916 665319..666482 1 NC_008023.1 methyltransferase 666482 4064916 MGAS2096_Spy0688 Streptococcus pyogenes MGAS2096 methyltransferase YP_600284.1 665319 D 370565 CDS YP_600285.1 94992186 4064917 666479..667165 1 NC_008023.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 667165 aroD 4064917 aroD Streptococcus pyogenes MGAS2096 3-dehydroquinate dehydratase YP_600285.1 666479 D 370565 CDS YP_600286.1 94992187 4064918 667259..668425 1 NC_008023.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 668425 aroF 4064918 aroF Streptococcus pyogenes MGAS2096 chorismate synthase YP_600286.1 667259 D 370565 CDS YP_600287.1 94992188 4064919 668486..668827 1 NC_008023.1 hypothetical protein 668827 4064919 MGAS2096_Spy0691 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600287.1 668486 D 370565 CDS YP_600288.1 94992189 4064920 669039..670400 1 NC_008023.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 670400 gor 4064920 gor Streptococcus pyogenes MGAS2096 glutathione reductase YP_600288.1 669039 D 370565 CDS YP_600289.1 94992190 4064921 complement(670488..671780) 1 NC_008023.1 bifunctional; folylpolyglutamate synthase / dihydrofolate synthase 671780 folC2 4064921 folC2 Streptococcus pyogenes MGAS2096 folylpolyglutamate synthase / dihydrofolate synthase YP_600289.1 670488 R 370565 CDS YP_600290.1 94992191 4064922 complement(671786..672247) 1 NC_008023.1 hypothetical protein 672247 4064922 MGAS2096_Spy0694 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600290.1 671786 R 370565 CDS YP_600291.1 94992192 4065303 672461..673603 1 NC_008023.1 bifunctional; cysteine desulfurase / selenocysteine lyase 673603 nifS1 4065303 nifS1 Streptococcus pyogenes MGAS2096 cysteine desulfurase / selenocysteine lyase YP_600291.1 672461 D 370565 CDS YP_600292.1 94992193 4065304 673615..674829 1 NC_008023.1 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 674829 thiI 4065304 thiI Streptococcus pyogenes MGAS2096 thiamine biosynthesis protein ThiI YP_600292.1 673615 D 370565 CDS YP_600293.1 94992194 4065305 674867..675739 1 NC_008023.1 capsule biosynthesis protein capA 675739 capA 4065305 capA Streptococcus pyogenes MGAS2096 capsule biosynthesis protein capA YP_600293.1 674867 D 370565 CDS YP_600294.1 94992195 4065306 675736..676161 1 NC_008023.1 capsule biosynthesis protein capA 676161 4065306 MGAS2096_Spy0698 Streptococcus pyogenes MGAS2096 capsule biosynthesis protein capA YP_600294.1 675736 D 370565 CDS YP_600295.1 94992196 4065307 676375..676689 1 NC_008023.1 50S ribosomal protein L21 676689 rplU 4065307 rplU Streptococcus pyogenes MGAS2096 50S ribosomal protein L21 YP_600295.1 676375 D 370565 CDS YP_600296.1 94992197 4065308 676701..677027 1 NC_008023.1 hypothetical protein 677027 4065308 MGAS2096_Spy0700 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600296.1 676701 D 370565 CDS YP_600297.1 94992198 4065309 677055..677348 1 NC_008023.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 677348 rpmA 4065309 rpmA Streptococcus pyogenes MGAS2096 50S ribosomal protein L27 YP_600297.1 677055 D 370565 CDS YP_600298.1 94992199 4065310 677696..678613 1 NC_008023.1 LysR family transcriptional regulator 678613 4065310 MGAS2096_Spy0702 Streptococcus pyogenes MGAS2096 LysR family transcriptional regulator YP_600298.1 677696 D 370565 CDS YP_600299.1 94992200 4065311 678610..679068 1 NC_008023.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 679068 lsp 4065311 lsp Streptococcus pyogenes MGAS2096 lipoprotein signal peptidase YP_600299.1 678610 D 370565 CDS YP_600300.1 94992201 4065312 679058..679252 1 NC_008023.1 ribosomal large subunit pseudouridine synthase D 679252 4065312 MGAS2096_Spy0704 Streptococcus pyogenes MGAS2096 ribosomal large subunit pseudouridine synthase D YP_600300.1 679058 D 370565 CDS YP_600301.1 94992202 4065313 679276..679947 1 NC_008023.1 ribosomal large subunit pseudouridine synthase D 679947 4065313 MGAS2096_Spy0705 Streptococcus pyogenes MGAS2096 ribosomal large subunit pseudouridine synthase D YP_600301.1 679276 D 370565 CDS YP_600302.1 94992203 4065314 680343..680864 1 NC_008023.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 680864 pyrR 4065314 pyrR Streptococcus pyogenes MGAS2096 bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase YP_600302.1 680343 D 370565 CDS YP_600303.1 94992204 4065315 680880..682139 1 NC_008023.1 Uracil permease 682139 pyrP 4065315 pyrP Streptococcus pyogenes MGAS2096 Uracil permease YP_600303.1 680880 D 370565 CDS YP_600304.1 94992205 4065316 682146..683135 1 NC_008023.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit 683135 pyrB 4065316 pyrB Streptococcus pyogenes MGAS2096 aspartate carbamoyltransferase catalytic subunit YP_600304.1 682146 D 370565 CDS YP_600305.1 94992206 4065317 683179..684261 1 NC_008023.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 684261 carA 4065317 carA Streptococcus pyogenes MGAS2096 carbamoyl phosphate synthase small subunit YP_600305.1 683179 D 370565 CDS YP_600306.1 94992207 4065318 684233..684430 1 NC_008023.1 hypothetical protein 684430 4065318 MGAS2096_Spy0710 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600306.1 684233 D 370565 CDS YP_600307.2 162139133 4065319 684507..687683 1 NC_008023.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 687683 carB 4065319 carB Streptococcus pyogenes MGAS2096 carbamoyl phosphate synthase large subunit YP_600307.2 684507 D 370565 CDS YP_600308.1 94992209 4065320 687889..689160 1 NC_008023.1 periplasmic protein of efflux system 689160 4065320 MGAS2096_Spy0712 Streptococcus pyogenes MGAS2096 periplasmic protein of efflux system YP_600308.1 687889 D 370565 CDS YP_600309.1 94992210 4065321 689160..689870 1 NC_008023.1 ABC transporter ATP-binding protein 689870 4065321 MGAS2096_Spy0713 Streptococcus pyogenes MGAS2096 ABC transporter ATP-binding protein YP_600309.1 689160 D 370565 CDS YP_600310.1 94992211 4066137 689882..691102 1 NC_008023.1 ABC transporter permease 691102 4066137 MGAS2096_Spy0714 Streptococcus pyogenes MGAS2096 ABC transporter permease YP_600310.1 689882 D 370565 CDS YP_600311.1 94992212 4066138 691314..693089 1 NC_008023.1 hypothetical protein 693089 4066138 MGAS2096_Spy0715 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600311.1 691314 D 370565 CDS YP_600312.1 94992213 4066139 693216..693488 1 NC_008023.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 693488 rpsP 4066139 rpsP Streptococcus pyogenes MGAS2096 30S ribosomal protein S16 YP_600312.1 693216 D 370565 CDS YP_600313.1 94992214 4066140 693498..693737 1 NC_008023.1 RNA binding protein 693737 4066140 MGAS2096_Spy0717 Streptococcus pyogenes MGAS2096 RNA binding protein YP_600313.1 693498 D 370565 CDS YP_600314.1 94992215 4066141 693746..693853 1 NC_008023.1 hypothetical protein 693853 4066141 MGAS2096_Spy0718 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600314.1 693746 D 370565 CDS YP_600315.1 94992216 4066142 694669..697695 1 NC_008023.1 cell surface protein 697695 4066142 MGAS2096_Spy0719 Streptococcus pyogenes MGAS2096 cell surface protein YP_600315.1 694669 D 370565 CDS YP_600316.1 94992217 4066143 697715..698116 1 NC_008023.1 putative cytoplasmic protein 698116 4066143 MGAS2096_Spy0720 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600316.1 697715 D 370565 CDS YP_600317.1 94992218 4066144 complement(698310..699185) 1 NC_008023.1 cobalt-zinc-cadmium resistance protein czcD 699185 czcD 4066144 czcD Streptococcus pyogenes MGAS2096 cobalt-zinc-cadmium resistance protein czcD YP_600317.1 698310 R 370565 CDS YP_600318.1 94992219 4066145 699312..699842 1 NC_008023.1 TetR family transcriptional regulator 699842 4066145 MGAS2096_Spy0722 Streptococcus pyogenes MGAS2096 TetR family transcriptional regulator YP_600318.1 699312 D 370565 CDS YP_600319.1 94992220 4066146 700057..700308 1 NC_008023.1 16S rRNA processing protein rimM 700308 4066146 MGAS2096_Spy0723 Streptococcus pyogenes MGAS2096 16S rRNA processing protein rimM YP_600319.1 700057 D 370565 CDS YP_600320.1 94992221 4066147 700263..700574 1 NC_008023.1 16S rRNA processing protein rimM 700574 rimM 4066147 rimM Streptococcus pyogenes MGAS2096 16S rRNA processing protein rimM YP_600320.1 700263 D 370565 CDS YP_600321.1 94992222 4066148 700564..701040 1 NC_008023.1 tRNA (guanine-N(1)-)-methyltransferase 701040 trmD 4066148 trmD Streptococcus pyogenes MGAS2096 tRNA (guanine-N(1)-)-methyltransferase YP_600321.1 700564 D 370565 CDS YP_600322.1 94992223 4066149 701024..701284 1 NC_008023.1 tRNA (guanine-N(1)-)-methyltransferase 701284 4066149 MGAS2096_Spy0726 Streptococcus pyogenes MGAS2096 tRNA (guanine-N(1)-)-methyltransferase YP_600322.1 701024 D 370565 CDS YP_600323.1 94992224 4066150 701296..702288 1 NC_008023.1 thioredoxin reductase 702288 trxB 4066150 trxB Streptococcus pyogenes MGAS2096 thioredoxin reductase YP_600323.1 701296 D 370565 CDS YP_600324.1 94992225 4066151 702464..703522 1 NC_008023.1 hypothetical protein 703522 4066151 MGAS2096_Spy0728 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600324.1 702464 D 370565 CDS YP_600325.1 94992226 4066152 703535..704458 1 NC_008023.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 704458 apbA 4066152 apbA Streptococcus pyogenes MGAS2096 2-dehydropantoate 2-reductase YP_600325.1 703535 D 370565 CDS YP_600326.1 94992227 4066153 704714..705427 1 NC_008023.1 fructose repressor 705427 fruR 4066153 fruR Streptococcus pyogenes MGAS2096 fructose repressor YP_600326.1 704714 D 370565 CDS YP_600327.1 94992228 4066154 705424..705906 1 NC_008023.1 1-phosphofructokinase 705906 fruB 4066154 fruB Streptococcus pyogenes MGAS2096 1-phosphofructokinase YP_600327.1 705424 D 370565 CDS YP_600328.1 94992229 4066155 705887..706336 1 NC_008023.1 1-phosphofructokinase 706336 4066155 MGAS2096_Spy0732 Streptococcus pyogenes MGAS2096 1-phosphofructokinase YP_600328.1 705887 D 370565 CDS YP_600329.1 94992230 4066156 706333..708279 1 NC_008023.1 PTS system fructose-specific transporter subunit IIABC 708279 fruA 4066156 fruA Streptococcus pyogenes MGAS2096 PTS system fructose-specific transporter subunit IIABC YP_600329.1 706333 D 370565 CDS YP_600330.1 94992231 4066098 708372..708971 1 NC_008023.1 N-acetylmuramidase 708971 mur1-1 4066098 mur1-1 Streptococcus pyogenes MGAS2096 N-acetylmuramidase YP_600330.1 708372 D 370565 CDS YP_600331.1 94992232 4066099 709123..709830 1 NC_008023.1 N-acetylmuramidase 709830 mur1-2 4066099 mur1-2 Streptococcus pyogenes MGAS2096 N-acetylmuramidase YP_600331.1 709123 D 370565 CDS YP_600332.1 94992233 4066100 complement(709887..710105) 1 NC_008023.1 transposase 710105 4066100 MGAS2096_Spy0736 Streptococcus pyogenes MGAS2096 transposase YP_600332.1 709887 R 370565 CDS YP_600333.1 94992234 4066101 complement(710308..710427) 1 NC_008023.1 hypothetical protein 710427 4066101 MGAS2096_Spy0737 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600333.1 710308 R 370565 CDS YP_600334.1 94992235 4066102 complement(710402..710614) 1 NC_008023.1 exotoxin type C 710614 4066102 MGAS2096_Spy0738 Streptococcus pyogenes MGAS2096 exotoxin type C YP_600334.1 710402 R 370565 CDS YP_600335.1 94992236 4066103 complement(710787..711812) 1 NC_008023.1 hypothetical protein 711812 mac 4066103 mac Streptococcus pyogenes MGAS2096 hypothetical protein YP_600335.1 710787 R 370565 CDS YP_600336.1 94992237 4066104 711968..712087 1 NC_008023.1 phage protein 712087 4066104 MGAS2096_Spy0740 Streptococcus pyogenes MGAS2096 phage protein YP_600336.1 711968 D 370565 CDS YP_600337.1 94992238 4066105 712312..712488 1 NC_008023.1 nucleoside diphosphate kinase 712488 4066105 MGAS2096_Spy0741 Streptococcus pyogenes MGAS2096 nucleoside diphosphate kinase YP_600337.1 712312 D 370565 CDS YP_600338.1 94992239 4066106 712716..713096 1 NC_008023.1 putative cytoplasmic protein 713096 4066106 MGAS2096_Spy0742 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600338.1 712716 D 370565 CDS YP_600339.1 94992240 4066107 713096..713944 1 NC_008023.1 DegV family protein 713944 4066107 MGAS2096_Spy0743 Streptococcus pyogenes MGAS2096 DegV family protein YP_600339.1 713096 D 370565 CDS YP_600340.1 94992241 4066108 714069..715277 1 NC_008023.1 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase 715277 papS 4066108 papS Streptococcus pyogenes MGAS2096 tRNA CCA-pyrophosphorylase YP_600340.1 714069 D 370565 CDS YP_600341.1 94992242 4066109 715274..717151 1 NC_008023.1 ABC transporter ATP-binding protein uup 717151 4066109 MGAS2096_Spy0745 Streptococcus pyogenes MGAS2096 ABC transporter ATP-binding protein uup YP_600341.1 715274 D 370565 CDS YP_600342.1 94992243 4066110 717548..717673 1 NC_008023.1 hypothetical protein 717673 4066110 MGAS2096_Spy0746 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600342.1 717548 D 370565 CDS YP_600343.1 94992244 4066111 717567..717785 1 NC_008023.1 hypothetical protein 717785 4066111 MGAS2096_Spy0747 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600343.1 717567 D 370565 CDS YP_600344.1 94992245 4066112 718041..718451 1 NC_008023.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 718451 fms 4066112 fms Streptococcus pyogenes MGAS2096 peptide deformylase YP_600344.1 718041 D 370565 CDS YP_600345.1 94992246 4066113 complement(718533..720584) 1 NC_008023.1 5'-nucleotidase 720584 4066113 MGAS2096_Spy0749 Streptococcus pyogenes MGAS2096 5'-nucleotidase YP_600345.1 718533 R 370565 CDS YP_600346.1 94992247 4066114 720765..721415 1 NC_008023.1 GTP pyrophosphokinase 721415 4066114 MGAS2096_Spy0750 Streptococcus pyogenes MGAS2096 GTP pyrophosphokinase YP_600346.1 720765 D 370565 CDS YP_600347.1 94992248 4066115 721418..722086 1 NC_008023.1 two-component response regulator 722086 sptR 4066115 sptR Streptococcus pyogenes MGAS2096 two-component response regulator YP_600347.1 721418 D 370565 CDS YP_600348.1 94992249 4066116 722068..723327 1 NC_008023.1 two-component system histidine kinase 723327 sptS 4066116 sptS Streptococcus pyogenes MGAS2096 two-component system histidine kinase YP_600348.1 722068 D 370565 CDS YP_600349.1 94992250 4066078 723631..724509 1 NC_008023.1 mevalonate kinase 724509 mvaK1 4066078 mvaK1 Streptococcus pyogenes MGAS2096 mevalonate kinase YP_600349.1 723631 D 370565 CDS YP_600350.1 94992251 4066079 724491..725435 1 NC_008023.1 diphosphomevalonate decarboxylase 725435 mvaD 4066079 mvaD Streptococcus pyogenes MGAS2096 diphosphomevalonate decarboxylase YP_600350.1 724491 D 370565 CDS YP_600351.1 94992252 4066080 725380..726441 1 NC_008023.1 phosphomevalonate kinase 726441 mvaK2 4066080 mvaK2 Streptococcus pyogenes MGAS2096 phosphomevalonate kinase YP_600351.1 725380 D 370565 CDS YP_600352.1 94992253 4066081 726338..727417 1 NC_008023.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase 727417 4066081 MGAS2096_Spy0756 Streptococcus pyogenes MGAS2096 isopentenyl pyrophosphate isomerase YP_600352.1 726338 D 370565 CDS YP_600353.1 94992254 4066082 727580..728443 1 NC_008023.1 transposase 728443 4066082 MGAS2096_Spy0757 Streptococcus pyogenes MGAS2096 transposase YP_600353.1 727580 D 370565 CDS YP_600354.1 94992255 4066083 complement(728615..729892) 1 NC_008023.1 bifunctional; 3-hydroxy-3-methylglutaryl-coenzyme A reductase / 3-hydroxy-3-methylglutaryl-coenzyme A reductase 729892 4066083 MGAS2096_Spy0758 Streptococcus pyogenes MGAS2096 3-hydroxy-3-methylglutaryl-coenzyme A reductase / 3-hydroxy-3-methylglutaryl-coenzyme A reductase YP_600354.1 728615 R 370565 CDS YP_600355.1 94992256 4066084 complement(729879..731093) 1 NC_008023.1 hydroxymethylglutaryl-CoA synthase 731093 mvaS1 4066084 mvaS1 Streptococcus pyogenes MGAS2096 hydroxymethylglutaryl-CoA synthase YP_600355.1 729879 R 370565 CDS YP_600356.1 94992257 4066085 731239..732102 1 NC_008023.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 732102 thyA 4066085 thyA Streptococcus pyogenes MGAS2096 thymidylate synthase YP_600356.1 731239 D 370565 CDS YP_600357.1 94992258 4066086 732182..732679 1 NC_008023.1 dihydrofolate reductase 732679 dyr 4066086 dyr Streptococcus pyogenes MGAS2096 dihydrofolate reductase YP_600357.1 732182 D 370565 CDS YP_600358.1 94992259 4066087 732699..732869 1 NC_008023.1 hypothetical protein 732869 4066087 MGAS2096_Spy0762 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600358.1 732699 D 370565 CDS YP_600359.1 94992260 4066088 732999..734228 1 NC_008023.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 734228 clpX 4066088 clpX Streptococcus pyogenes MGAS2096 ATP-dependent protease ATP-binding subunit ClpX YP_600359.1 732999 D 370565 CDS YP_600360.1 94992261 4066089 734238..734837 1 NC_008023.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 734837 engB 4066089 engB Streptococcus pyogenes MGAS2096 ribosome biogenesis GTP-binding protein YsxC YP_600360.1 734238 D 370565 CDS YP_600361.1 94992262 4066090 734985..735728 1 NC_008023.1 hypothetical protein 735728 4066090 MGAS2096_Spy0765 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600361.1 734985 D 370565 CDS YP_600362.1 94992263 4066091 complement(735786..737885) 1 NC_008023.1 ATP-dependent endopeptidase Clp ATP-binding subunit clpL 737885 clpL 4066091 clpL Streptococcus pyogenes MGAS2096 ATP-dependent endopeptidase Clp ATP-binding subunit clpL YP_600362.1 735786 R 370565 CDS YP_600363.1 94992264 4066092 738263..738946 1 NC_008023.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 738946 rpiA 4066092 rpiA Streptococcus pyogenes MGAS2096 ribose-5-phosphate isomerase A YP_600363.1 738263 D 370565 CDS YP_600364.1 94992265 4066093 739023..740234 1 NC_008023.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 740234 deoB 4066093 deoB Streptococcus pyogenes MGAS2096 phosphopentomutase YP_600364.1 739023 D 370565 CDS YP_600365.1 94992266 4066094 740247..740693 1 NC_008023.1 arsenate reductase 740693 arsC 4066094 arsC Streptococcus pyogenes MGAS2096 arsenate reductase YP_600365.1 740247 D 370565 CDS YP_600366.1 94992267 4066095 740677..741486 1 NC_008023.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 741486 punA 4066095 punA Streptococcus pyogenes MGAS2096 purine nucleoside phosphorylase YP_600366.1 740677 D 370565 CDS YP_600367.1 94992268 4066096 742149..742862 1 NC_008023.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 742862 deoD 4066096 deoD Streptococcus pyogenes MGAS2096 purine nucleoside phosphorylase YP_600367.1 742149 D 370565 CDS YP_600368.1 94992269 4066097 742849..743643 1 NC_008023.1 histidine protein kinase 743643 cpsX 4066097 cpsX Streptococcus pyogenes MGAS2096 histidine protein kinase YP_600368.1 742849 D 370565 CDS YP_600369.1 94992270 4066061 complement(743723..744628) 1 NC_008023.1 LysR family transcriptional regulator 744628 cpsY 4066061 cpsY Streptococcus pyogenes MGAS2096 LysR family transcriptional regulator YP_600369.1 743723 R 370565 CDS YP_600370.1 94992271 4066062 744850..745386 1 NC_008023.1 hypothetical protein 745386 4066062 MGAS2096_Spy0774 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600370.1 744850 D 370565 CDS YP_600371.1 94992272 4066063 745663..746355 1 NC_008023.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 746355 pyrF 4066063 pyrF Streptococcus pyogenes MGAS2096 orotidine 5'-phosphate decarboxylase YP_600371.1 745663 D 370565 CDS YP_600372.1 94992273 4066064 746413..747042 1 NC_008023.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 747042 pyrE 4066064 pyrE Streptococcus pyogenes MGAS2096 orotate phosphoribosyltransferase YP_600372.1 746413 D 370565 CDS YP_600373.1 94992274 4066065 747239..748693 1 NC_008023.1 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 748693 amiC 4066065 amiC Streptococcus pyogenes MGAS2096 amidase YP_600373.1 747239 D 370565 CDS YP_600374.1 94992275 4066066 748775..749674 1 NC_008023.1 cystine-binding protein 749674 4066066 MGAS2096_Spy0778 Streptococcus pyogenes MGAS2096 cystine-binding protein YP_600374.1 748775 D 370565 CDS YP_600375.1 94992276 4066067 749703..750353 1 NC_008023.1 cystine transport system permease 750353 4066067 MGAS2096_Spy0779 Streptococcus pyogenes MGAS2096 cystine transport system permease YP_600375.1 749703 D 370565 CDS YP_600376.1 94992277 4066068 750486..751139 1 NC_008023.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 751139 ung 4066068 ung Streptococcus pyogenes MGAS2096 uracil-DNA glycosylase YP_600376.1 750486 D 370565 CDS YP_600377.1 94992278 4066069 751271..752539 1 NC_008023.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 752539 pyrC 4066069 pyrC Streptococcus pyogenes MGAS2096 dihydroorotase YP_600377.1 751271 D 370565 CDS YP_600378.1 94992279 4066070 complement(752597..753319) 1 NC_008023.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; putative glycerol-3-phosphate acyltransferase PlsY 753319 4066070 MGAS2096_Spy0782 Streptococcus pyogenes MGAS2096 putative glycerol-3-phosphate acyltransferase PlsY YP_600378.1 752597 R 370565 CDS YP_600379.1 94992280 4066071 753370..755322 1 NC_008023.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 755322 parE 4066071 parE Streptococcus pyogenes MGAS2096 DNA topoisomerase IV subunit B YP_600379.1 753370 D 370565 CDS YP_600380.1 94992281 4066072 755407..757872 1 NC_008023.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 757872 parC 4066072 parC Streptococcus pyogenes MGAS2096 DNA topoisomerase IV subunit A YP_600380.1 755407 D 370565 CDS YP_600381.1 94992282 4066073 757950..759005 1 NC_008023.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 759005 bcaT 4066073 bcaT Streptococcus pyogenes MGAS2096 branched-chain amino acid aminotransferase YP_600381.1 757950 D 370565 CDS YP_600382.1 94992283 4066074 759077..759301 1 NC_008023.1 putative cytoplasmic protein 759301 4066074 MGAS2096_Spy0786 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600382.1 759077 D 370565 CDS YP_600383.1 94992284 4066077 759700..760905 1 NC_008023.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 760905 rpsA 4066077 rpsA Streptococcus pyogenes MGAS2096 30S ribosomal protein S1 YP_600383.1 759700 D 370565 CDS YP_600384.1 94992285 4066043 complement(761452..761754) 1 NC_008023.1 hypothetical protein 761754 4066043 MGAS2096_Spy0788 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600384.1 761452 R 370565 CDS YP_600385.1 94992286 4066044 761954..762940 1 NC_008023.1 hypothetical protein 762940 4066044 MGAS2096_Spy0789 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600385.1 761954 D 370565 CDS YP_600386.1 94992287 4066045 763011..763202 1 NC_008023.1 hypothetical protein 763202 4066045 MGAS2096_Spy0790 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600386.1 763011 D 370565 CDS YP_600387.1 94992288 4066046 763335..763637 1 NC_008023.1 glutathione S-transferase 763637 4066046 MGAS2096_Spy0791 Streptococcus pyogenes MGAS2096 glutathione S-transferase YP_600387.1 763335 D 370565 CDS YP_600388.1 94992289 4066047 763937..764608 1 NC_008023.1 putative exfoliative toxin 764608 4066047 MGAS2096_Spy0792 Streptococcus pyogenes MGAS2096 putative exfoliative toxin YP_600388.1 763937 D 370565 CDS YP_600389.1 94992290 4066048 complement(764721..764903) 1 NC_008023.1 hypothetical protein 764903 4066048 MGAS2096_Spy0793 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600389.1 764721 R 370565 CDS YP_600390.1 94992291 4066049 765037..765936 1 NC_008023.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 765936 miaA 4066049 miaA Streptococcus pyogenes MGAS2096 tRNA delta(2)-isopentenylpyrophosphate transferase YP_600390.1 765037 D 370565 CDS YP_600391.1 94992292 4066050 765997..767247 1 NC_008023.1 GTP-binding protein hflX 767247 hflX 4066050 hflX Streptococcus pyogenes MGAS2096 GTP-binding protein hflX YP_600391.1 765997 D 370565 CDS YP_600392.1 94992293 4066051 767228..767875 1 NC_008023.1 hypothetical protein 767875 4066051 MGAS2096_Spy0796 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600392.1 767228 D 370565 CDS YP_600393.1 94992294 4066052 767890..768819 1 NC_008023.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 768819 elaC 4066052 elaC Streptococcus pyogenes MGAS2096 ribonuclease Z YP_600393.1 767890 D 370565 CDS YP_600394.1 94992295 4066053 768819..769583 1 NC_008023.1 short-chain dehydrogenase 769583 4066053 MGAS2096_Spy0798 Streptococcus pyogenes MGAS2096 short-chain dehydrogenase YP_600394.1 768819 D 370565 CDS YP_600395.1 94992296 4066054 769580..771790 1 NC_008023.1 single-stranded-DNA-specific exonuclease recJ 771790 recJ 4066054 recJ Streptococcus pyogenes MGAS2096 single-stranded-DNA-specific exonuclease recJ YP_600395.1 769580 D 370565 CDS YP_600396.1 94992297 4066055 771941..772459 1 NC_008023.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 772459 apt 4066055 apt Streptococcus pyogenes MGAS2096 adenine phosphoribosyltransferase YP_600396.1 771941 D 370565 CDS YP_600397.1 94992298 4066056 772540..773223 1 NC_008023.1 DNA replication protein dnaD 773223 dnaD 4066056 dnaD Streptococcus pyogenes MGAS2096 DNA replication protein dnaD YP_600397.1 772540 D 370565 CDS YP_600398.1 94992299 4066057 773220..773876 1 NC_008023.1 endonuclease III 773876 nth 4066057 nth Streptococcus pyogenes MGAS2096 endonuclease III YP_600398.1 773220 D 370565 CDS YP_600399.1 94992300 4066058 773948..774634 1 NC_008023.1 putative cytoplasmic protein 774634 4066058 MGAS2096_Spy0803 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600399.1 773948 D 370565 CDS YP_600400.1 94992301 4066059 774618..774794 1 NC_008023.1 NIF3-like protein 774794 4066059 MGAS2096_Spy0804 Streptococcus pyogenes MGAS2096 NIF3-like protein YP_600400.1 774618 D 370565 CDS YP_600401.1 94992302 4066060 774883..775257 1 NC_008023.1 NIF3-like protein 775257 4066060 MGAS2096_Spy0805 Streptococcus pyogenes MGAS2096 NIF3-like protein YP_600401.1 774883 D 370565 CDS YP_600402.1 94992303 4066023 775191..775412 1 NC_008023.1 NIF3-like protein 775412 4066023 MGAS2096_Spy0806 Streptococcus pyogenes MGAS2096 NIF3-like protein YP_600402.1 775191 D 370565 CDS YP_600403.1 94992304 4066024 775447..776553 1 NC_008023.1 glycine/D-amino acid oxidase family protein 776553 4066024 MGAS2096_Spy0807 Streptococcus pyogenes MGAS2096 glycine/D-amino acid oxidase family protein YP_600403.1 775447 D 370565 CDS YP_600404.1 94992305 4066025 776611..777480 1 NC_008023.1 glucose-1-phosphate thymidylyltransferase 777480 cpsFO 4066025 cpsFO Streptococcus pyogenes MGAS2096 glucose-1-phosphate thymidylyltransferase YP_600404.1 776611 D 370565 CDS YP_600405.1 94992306 4066026 777480..777644 1 NC_008023.1 dTDP-4-dehydrorhamnose 3,5-epimerase 777644 4066026 MGAS2096_Spy0809 Streptococcus pyogenes MGAS2096 dTDP-4-dehydrorhamnose 3,5-epimerase YP_600405.1 777480 D 370565 CDS YP_600406.1 94992307 4066027 777577..778071 1 NC_008023.1 dTDP-4-dehydrorhamnose 3,5-epimerase 778071 cpsFP 4066027 cpsFP Streptococcus pyogenes MGAS2096 dTDP-4-dehydrorhamnose 3,5-epimerase YP_600406.1 777577 D 370565 CDS YP_600407.1 94992308 4066028 778315..779355 1 NC_008023.1 dTDP-glucose 4,6-dehydratase 779355 cpsFQ 4066028 cpsFQ Streptococcus pyogenes MGAS2096 dTDP-glucose 4,6-dehydratase YP_600407.1 778315 D 370565 CDS YP_600408.1 94992309 4066029 779576..780052 1 NC_008023.1 7,8-dihydro-8-oxoguanine-triphosphatase 780052 4066029 MGAS2096_Spy0812 Streptococcus pyogenes MGAS2096 7,8-dihydro-8-oxoguanine-triphosphatase YP_600408.1 779576 D 370565 CDS YP_600409.1 94992310 4066030 780110..781291 1 NC_008023.1 hypothetical protein 781291 4066030 MGAS2096_Spy0813 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600409.1 780110 D 370565 CDS YP_600410.1 94992311 4066031 781263..782528 1 NC_008023.1 hypothetical protein 782528 4066031 MGAS2096_Spy0814 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600410.1 781263 D 370565 CDS YP_600411.1 94992312 4066032 complement(782587..784281) 1 NC_008023.1 fibronectin-binding protein / fibrinogen-binding protein 784281 fbp 4066032 fbp Streptococcus pyogenes MGAS2096 fibronectin-binding protein / fibrinogen-binding protein YP_600411.1 782587 R 370565 CDS YP_600412.1 94992313 4066033 784286..784411 1 NC_008023.1 hypothetical protein 784411 4066033 MGAS2096_Spy0816 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600412.1 784286 D 370565 CDS YP_600413.1 94992314 4066034 784593..785591 1 NC_008023.1 hypothetical protein 785591 4066034 MGAS2096_Spy0817 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600413.1 784593 D 370565 CDS YP_600414.1 94992315 4066035 785924..786805 1 NC_008023.1 ABC transporter permease 786805 4066035 MGAS2096_Spy0818 Streptococcus pyogenes MGAS2096 ABC transporter permease YP_600414.1 785924 D 370565 CDS YP_600415.1 94992316 4066036 786802..787560 1 NC_008023.1 ABC transporter ATP-binding protein 787560 4066036 MGAS2096_Spy0819 Streptococcus pyogenes MGAS2096 ABC transporter ATP-binding protein YP_600415.1 786802 D 370565 CDS YP_600416.1 94992317 4066037 787764..789425 1 NC_008023.1 Zn-dependent hydrolase 789425 4066037 MGAS2096_Spy0820 Streptococcus pyogenes MGAS2096 Zn-dependent hydrolase YP_600416.1 787764 D 370565 CDS YP_600417.1 94992318 4066038 789558..790343 1 NC_008023.1 Acetyl esterase 790343 estA 4066038 estA Streptococcus pyogenes MGAS2096 Acetyl esterase YP_600417.1 789558 D 370565 CDS YP_600418.1 94992319 4066039 790493..790699 1 NC_008023.1 hypothetical protein 790699 4066039 MGAS2096_Spy0822 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600418.1 790493 D 370565 CDS YP_600419.1 94992320 4066040 790745..792652 1 NC_008023.1 ABC transporter ATP-binding protein 792652 4066040 MGAS2096_Spy0823 Streptococcus pyogenes MGAS2096 ABC transporter ATP-binding protein YP_600419.1 790745 D 370565 CDS YP_600420.1 94992321 4066041 792927..793907 1 NC_008023.1 pyruvate dehydrogenase E1 component alpha subunit 793907 acoA 4066041 acoA Streptococcus pyogenes MGAS2096 pyruvate dehydrogenase E1 component alpha subunit YP_600420.1 792927 D 370565 CDS YP_600421.1 94992322 4066003 793963..794964 1 NC_008023.1 pyruvate dehydrogenase E1 component beta subunit 794964 acoB 4066003 acoB Streptococcus pyogenes MGAS2096 pyruvate dehydrogenase E1 component beta subunit YP_600421.1 793963 D 370565 CDS YP_600422.1 94992323 4066004 795149..796558 1 NC_008023.1 branched-chain alpha-keto acid dehydrogenase subunit E2 796558 acoC 4066004 acoC Streptococcus pyogenes MGAS2096 branched-chain alpha-keto acid dehydrogenase subunit E2 YP_600422.1 795149 D 370565 CDS YP_600423.1 94992324 4066005 complement(796613..796852) 1 NC_008023.1 hypothetical protein 796852 4066005 MGAS2096_Spy0827 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600423.1 796613 R 370565 CDS YP_600424.1 94992325 4066006 796885..798648 1 NC_008023.1 dihydrolipoamide dehydrogenase 798648 acoL 4066006 acoL Streptococcus pyogenes MGAS2096 dihydrolipoamide dehydrogenase YP_600424.1 796885 D 370565 CDS YP_600425.1 94992326 4066007 complement(798664..798891) 1 NC_008023.1 hypothetical protein 798891 4066007 MGAS2096_Spy0829 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600425.1 798664 R 370565 CDS YP_600426.1 94992327 4066008 complement(799322..801229) 1 NC_008023.1 hyaluronate lyase 801229 hylA 4066008 hylA Streptococcus pyogenes MGAS2096 hyaluronate lyase YP_600426.1 799322 R 370565 CDS YP_600427.1 94992328 4066009 complement(801301..801807) 1 NC_008023.1 hyaluronate lyase 801807 4066009 MGAS2096_Spy0831 Streptococcus pyogenes MGAS2096 hyaluronate lyase YP_600427.1 801301 R 370565 CDS YP_600428.1 94992329 4066010 801971..802960 1 NC_008023.1 lipoate-protein ligase A 802960 lplB 4066010 lplB Streptococcus pyogenes MGAS2096 lipoate-protein ligase A YP_600428.1 801971 D 370565 CDS YP_600429.1 94992330 4066011 complement(803069..803860) 1 NC_008023.1 glutamine amidotransferase 803860 4066011 MGAS2096_Spy0833 Streptococcus pyogenes MGAS2096 glutamine amidotransferase YP_600429.1 803069 R 370565 CDS YP_600430.1 94992331 4066012 complement(803860..805203) 1 NC_008023.1 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 805203 4066012 MGAS2096_Spy0834 Streptococcus pyogenes MGAS2096 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_600430.1 803860 R 370565 CDS YP_600431.1 94992332 4066013 805310..806161 1 NC_008023.1 hypothetical protein 806161 4066013 MGAS2096_Spy0835 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600431.1 805310 D 370565 CDS YP_600432.1 94992333 4066014 806158..807114 1 NC_008023.1 hypothetical protein 807114 4066014 MGAS2096_Spy0836 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600432.1 806158 D 370565 CDS YP_600433.1 94992334 4066015 807168..808523 1 NC_008023.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 808523 glmM 4066015 glmM Streptococcus pyogenes MGAS2096 phosphoglucosamine mutase YP_600433.1 807168 D 370565 CDS YP_600434.1 94992335 4066016 808647..809288 1 NC_008023.1 hypothetical protein 809288 4066016 MGAS2096_Spy0838 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600434.1 808647 D 370565 CDS YP_600435.1 94992336 4066017 809255..810481 1 NC_008023.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 810481 hemN 4066017 hemN Streptococcus pyogenes MGAS2096 coproporphyrinogen III oxidase YP_600435.1 809255 D 370565 CDS YP_600436.1 94992337 4066018 810491..811243 1 NC_008023.1 acyl-acyl-carrier protein thioesterase 811243 4066018 MGAS2096_Spy0840 Streptococcus pyogenes MGAS2096 acyl-acyl-carrier protein thioesterase YP_600436.1 810491 D 370565 CDS YP_600437.1 94992338 4066019 811243..812007 1 NC_008023.1 haloacid dehalogenase-like hydrolase 812007 4066019 MGAS2096_Spy0841 Streptococcus pyogenes MGAS2096 haloacid dehalogenase-like hydrolase YP_600437.1 811243 D 370565 CDS YP_600438.1 94992339 4066020 811995..812639 1 NC_008023.1 hypothetical protein 812639 4066020 MGAS2096_Spy0842 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600438.1 811995 D 370565 CDS YP_600439.1 94992340 4066021 813084..817190 1 NC_008023.1 putative cytoplasmic protein 817190 4066021 MGAS2096_Spy0843 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600439.1 813084 D 370565 CDS YP_600440.1 94992341 4066022 817190..818059 1 NC_008023.1 putative cytoplasmic protein 818059 4066022 MGAS2096_Spy0844 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600440.1 817190 D 370565 CDS YP_600441.1 94992342 4065984 818056..818397 1 NC_008023.1 putative cytoplasmic protein 818397 4065984 MGAS2096_Spy0845 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600441.1 818056 D 370565 CDS YP_600442.1 94992343 4065985 818321..819049 1 NC_008023.1 hypothetical protein 819049 4065985 MGAS2096_Spy0846 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600442.1 818321 D 370565 CDS YP_600443.1 94992344 4065986 819451..819630 1 NC_008023.1 nucleoside diphosphate kinase 819630 4065986 MGAS2096_Spy0847 Streptococcus pyogenes MGAS2096 nucleoside diphosphate kinase YP_600443.1 819451 D 370565 CDS YP_600444.1 94992345 4065987 819694..819942 1 NC_008023.1 nucleoside diphosphate kinase 819942 4065987 MGAS2096_Spy0848 Streptococcus pyogenes MGAS2096 nucleoside diphosphate kinase YP_600444.1 819694 D 370565 CDS YP_600445.1 94992346 4065988 819979..821121 1 NC_008023.1 transposase 821121 4065988 MGAS2096_Spy0849 Streptococcus pyogenes MGAS2096 transposase YP_600445.1 819979 D 370565 CDS YP_600446.1 94992347 4065989 821290..823197 1 NC_008023.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 823197 lepA 4065989 lepA Streptococcus pyogenes MGAS2096 GTP-binding protein LepA YP_600446.1 821290 D 370565 CDS YP_600447.1 94992348 4065990 823442..824650 1 NC_008023.1 collagen-like surface protein 824650 4065990 MGAS2096_Spy0851 Streptococcus pyogenes MGAS2096 collagen-like surface protein YP_600447.1 823442 D 370565 CDS YP_600448.1 94992349 4065991 824836..825273 1 NC_008023.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 825273 msrB 4065991 msrB Streptococcus pyogenes MGAS2096 methionine sulfoxide reductase B YP_600448.1 824836 D 370565 CDS YP_600449.1 94992350 4065992 825403..826422 1 NC_008023.1 hypothetical protein 826422 4065992 MGAS2096_Spy0853 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600449.1 825403 D 370565 CDS YP_600450.1 94992351 4065993 826629..827054 1 NC_008023.1 PTS system mannose/fructose family IIA subunit 827054 4065993 MGAS2096_Spy0854 Streptococcus pyogenes MGAS2096 PTS system mannose/fructose family IIA subunit YP_600450.1 826629 D 370565 CDS YP_600451.1 94992352 4065994 827073..827564 1 NC_008023.1 PTS system mannose/fructose family transporter subunit IIB 827564 ptsB 4065994 ptsB Streptococcus pyogenes MGAS2096 PTS system mannose/fructose family transporter subunit IIB YP_600451.1 827073 D 370565 CDS YP_600452.1 94992353 4065995 827581..828390 1 NC_008023.1 PTS system mannose/fructose family transporter subunit IIC 828390 ptsC 4065995 ptsC Streptococcus pyogenes MGAS2096 PTS system mannose/fructose family transporter subunit IIC YP_600452.1 827581 D 370565 CDS YP_600453.1 94992354 4065996 828387..829214 1 NC_008023.1 PTS system mannose/fructose family transporter subunit IID 829214 ptsD 4065996 ptsD Streptococcus pyogenes MGAS2096 PTS system mannose/fructose family transporter subunit IID YP_600453.1 828387 D 370565 CDS YP_600454.1 94992355 4065997 829350..830999 1 NC_008023.1 two-component sensor kinase yesM 830999 4065997 MGAS2096_Spy0858 Streptococcus pyogenes MGAS2096 two-component sensor kinase yesM YP_600454.1 829350 D 370565 CDS YP_600455.1 94992356 4065998 831003..831791 1 NC_008023.1 two-component response regulator yesN 831791 4065998 MGAS2096_Spy0859 Streptococcus pyogenes MGAS2096 two-component response regulator yesN YP_600455.1 831003 D 370565 CDS YP_600456.1 94992357 4065999 831785..832831 1 NC_008023.1 Iron(III)-binding protein 832831 4065999 MGAS2096_Spy0860 Streptococcus pyogenes MGAS2096 Iron(III)-binding protein YP_600456.1 831785 D 370565 CDS YP_600457.1 94992358 4066000 832943..834343 1 NC_008023.1 succinate-semialdehyde dehydrogenase 834343 gabD 4066000 gabD Streptococcus pyogenes MGAS2096 succinate-semialdehyde dehydrogenase YP_600457.1 832943 D 370565 CDS YP_600458.1 94992359 4066001 834445..836241 1 NC_008023.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 836241 uvrC 4066001 uvrC Streptococcus pyogenes MGAS2096 excinuclease ABC subunit C YP_600458.1 834445 D 370565 CDS YP_600459.1 94992360 4066002 836425..837027 1 NC_008023.1 NAD(P)H-dependent quinone reductase 837027 4066002 MGAS2096_Spy0863 Streptococcus pyogenes MGAS2096 NAD(P)H-dependent quinone reductase YP_600459.1 836425 D 370565 CDS YP_600460.2 162139132 4065944 837152..838561 1 NC_008023.1 divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases; dipeptidase PepV 838561 4065944 MGAS2096_Spy0864 Streptococcus pyogenes MGAS2096 dipeptidase PepV YP_600460.2 837152 D 370565 CDS YP_600461.1 94992362 4065945 complement(838629..839414) 1 NC_008023.1 tRNA (5-carboxymethylaminomethyl-2-thiouridylate) synthase 839414 thdF 4065945 thdF Streptococcus pyogenes MGAS2096 tRNA (5-carboxymethylaminomethyl-2-thiouridylate) synthase YP_600461.1 838629 R 370565 CDS YP_600462.1 94992363 4065946 complement(839359..840006) 1 NC_008023.1 tRNA (5-carboxymethylaminomethyl-2-thiouridylate) synthase 840006 4065946 MGAS2096_Spy0866 Streptococcus pyogenes MGAS2096 tRNA (5-carboxymethylaminomethyl-2-thiouridylate) synthase YP_600462.1 839359 R 370565 CDS YP_600463.2 162139131 4065947 840342..840842 1 NC_008023.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 840842 rplJ 4065947 rplJ Streptococcus pyogenes MGAS2096 50S ribosomal protein L10 YP_600463.2 840342 D 370565 CDS YP_600464.1 94992365 4065948 840892..841272 1 NC_008023.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 841272 rplL 4065948 rplL Streptococcus pyogenes MGAS2096 50S ribosomal protein L7/L12 YP_600464.1 840892 D 370565 CDS YP_600465.1 94992366 4065949 841628..841768 1 NC_008023.1 hypothetical protein 841768 4065949 MGAS2096_Spy0869 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600465.1 841628 D 370565 CDS YP_600466.1 94992367 4065950 841762..842130 1 NC_008023.1 hypothetical protein 842130 4065950 MGAS2096_Spy0870 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600466.1 841762 D 370565 CDS YP_600467.1 94992368 4065951 842109..842246 1 NC_008023.1 hypothetical protein 842246 4065951 MGAS2096_Spy0871 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600467.1 842109 D 370565 CDS YP_600468.1 94992369 4065952 842296..842628 1 NC_008023.1 DNA-cytosine methyltransferase 842628 4065952 MGAS2096_Spy0872 Streptococcus pyogenes MGAS2096 DNA-cytosine methyltransferase YP_600468.1 842296 D 370565 CDS YP_600469.1 94992370 4065953 842686..842898 1 NC_008023.1 relaxase 842898 4065953 MGAS2096_Spy0873 Streptococcus pyogenes MGAS2096 relaxase YP_600469.1 842686 D 370565 CDS YP_600470.1 94992371 4065954 842941..843153 1 NC_008023.1 relaxase 843153 4065954 MGAS2096_Spy0874 Streptococcus pyogenes MGAS2096 relaxase YP_600470.1 842941 D 370565 CDS YP_600471.1 94992372 4065955 843418..843729 1 NC_008023.1 relaxase 843729 4065955 MGAS2096_Spy0875 Streptococcus pyogenes MGAS2096 relaxase YP_600471.1 843418 D 370565 CDS YP_600472.1 94992373 4065956 843798..844115 1 NC_008023.1 relaxase 844115 srtI 4065956 srtI Streptococcus pyogenes MGAS2096 relaxase YP_600472.1 843798 D 370565 CDS YP_600473.1 94992374 4065957 844266..844952 1 NC_008023.1 two-component response regulator 844952 srtR 4065957 srtR Streptococcus pyogenes MGAS2096 two-component response regulator YP_600473.1 844266 D 370565 CDS YP_600474.1 94992375 4065958 844930..846291 1 NC_008023.1 lantibiotic biosynthesis sensor protein 846291 srtK 4065958 srtK Streptococcus pyogenes MGAS2096 lantibiotic biosynthesis sensor protein YP_600474.1 844930 D 370565 CDS YP_600475.1 94992376 4065959 846703..848493 1 NC_008023.1 lantibiotic ABC transporter permease 848493 srtT 4065959 srtT Streptococcus pyogenes MGAS2096 lantibiotic ABC transporter permease YP_600475.1 846703 D 370565 CDS YP_600476.1 94992377 4065960 848465..849721 1 NC_008023.1 lantibiotic biosynthesis; lanthionine synthetase 849721 4065960 MGAS2096_Spy0880 Streptococcus pyogenes MGAS2096 lanthionine synthetase YP_600476.1 848465 D 370565 CDS YP_600477.1 94992378 4065961 849740..852706 1 NC_008023.1 lantibiotic biosynthesis; Serine (threonine) dehydratase 852706 4065961 MGAS2096_Spy0881 Streptococcus pyogenes MGAS2096 Serine (threonine) dehydratase YP_600477.1 849740 D 370565 CDS YP_600478.1 94992379 4065962 852655..853401 1 NC_008023.1 lantibiotic ABC transporter ATP-binding protein 853401 srtF 4065962 srtF Streptococcus pyogenes MGAS2096 lantibiotic ABC transporter ATP-binding protein YP_600478.1 852655 D 370565 CDS YP_600479.1 94992380 4065963 853407..854156 1 NC_008023.1 lantibiotic ABC transporter permease 854156 srtE 4065963 srtE Streptococcus pyogenes MGAS2096 lantibiotic ABC transporter permease YP_600479.1 853407 D 370565 CDS YP_600480.1 94992381 4065925 854159..854881 1 NC_008023.1 lantibiotic ABC transporter permease 854881 srtG 4065925 srtG Streptococcus pyogenes MGAS2096 lantibiotic ABC transporter permease YP_600480.1 854159 D 370565 CDS YP_600481.1 94992382 4065926 855072..855290 1 NC_008023.1 Cro/CI family transcriptional regulator 855290 4065926 MGAS2096_Spy0885 Streptococcus pyogenes MGAS2096 Cro/CI family transcriptional regulator YP_600481.1 855072 D 370565 CDS YP_600482.1 94992383 4065927 complement(855399..855614) 1 NC_008023.1 hypothetical protein 855614 4065927 MGAS2096_Spy0886 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600482.1 855399 R 370565 CDS YP_600483.1 94992384 4065928 855814..855945 1 NC_008023.1 DNA integration/recombination/inversion protein 855945 4065928 MGAS2096_Spy0887 Streptococcus pyogenes MGAS2096 DNA integration/recombination/inversion protein YP_600483.1 855814 D 370565 CDS YP_600484.1 94992385 4065929 855967..856188 1 NC_008023.1 DNA integration/recombination/inversion protein 856188 4065929 MGAS2096_Spy0888 Streptococcus pyogenes MGAS2096 DNA integration/recombination/inversion protein YP_600484.1 855967 D 370565 CDS YP_600485.1 94992386 4065930 856261..856482 1 NC_008023.1 DNA integration/recombination/inversion protein 856482 4065930 MGAS2096_Spy0889 Streptococcus pyogenes MGAS2096 DNA integration/recombination/inversion protein YP_600485.1 856261 D 370565 CDS YP_600486.1 94992387 4065931 856513..856896 1 NC_008023.1 DNA integration/recombination/inversion protein 856896 4065931 MGAS2096_Spy0890 Streptococcus pyogenes MGAS2096 DNA integration/recombination/inversion protein YP_600486.1 856513 D 370565 CDS YP_600487.1 94992388 4065932 857039..858394 1 NC_008023.1 D-alanyl-D-alanine serine-type carboxypeptidase 858394 dacA1 4065932 dacA1 Streptococcus pyogenes MGAS2096 D-alanyl-D-alanine serine-type carboxypeptidase YP_600487.1 857039 D 370565 CDS YP_600488.1 94992389 4065933 complement(858511..859473) 1 NC_008023.1 polysaccharide deacetylase 859473 4065933 MGAS2096_Spy0892 Streptococcus pyogenes MGAS2096 polysaccharide deacetylase YP_600488.1 858511 R 370565 CDS YP_600489.1 94992390 4065934 859561..859716 1 NC_008023.1 hypothetical protein 859716 4065934 MGAS2096_Spy0893 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600489.1 859561 D 370565 CDS YP_600490.1 94992391 4065935 859706..861082 1 NC_008023.1 bifunctional; folylpolyglutamate synthase / dihydrofolate synthase 861082 folC1 4065935 folC1 Streptococcus pyogenes MGAS2096 folylpolyglutamate synthase / dihydrofolate synthase YP_600490.1 859706 D 370565 CDS YP_600491.1 94992392 4065936 861093..861701 1 NC_008023.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 861701 folE 4065936 folE Streptococcus pyogenes MGAS2096 GTP cyclohydrolase I YP_600491.1 861093 D 370565 CDS YP_600492.1 94992393 4065937 861710..862510 1 NC_008023.1 dihydropteroate synthase 862510 folP 4065937 folP Streptococcus pyogenes MGAS2096 dihydropteroate synthase YP_600492.1 861710 D 370565 CDS YP_600493.1 94992394 4065938 862517..862876 1 NC_008023.1 dihydroneopterin aldolase 862876 folQ 4065938 folQ Streptococcus pyogenes MGAS2096 dihydroneopterin aldolase YP_600493.1 862517 D 370565 CDS YP_600494.1 94992395 4065939 862873..863373 1 NC_008023.1 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 863373 folK 4065939 folK Streptococcus pyogenes MGAS2096 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase YP_600494.1 862873 D 370565 CDS YP_600495.1 94992396 4065940 863523..864410 1 NC_008023.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 864410 murB 4065940 murB Streptococcus pyogenes MGAS2096 UDP-N-acetylenolpyruvoylglucosamine reductase YP_600495.1 863523 D 370565 CDS YP_600496.1 94992397 4065941 864456..865610 1 NC_008023.1 spermidine/putrescine ABC transporter ATP-binding protein 865610 potA 4065941 potA Streptococcus pyogenes MGAS2096 spermidine/putrescine ABC transporter ATP-binding protein YP_600496.1 864456 D 370565 CDS YP_600497.1 94992398 4065942 865573..866388 1 NC_008023.1 spermidine/putrescine ABC transporter permease 866388 potB 4065942 potB Streptococcus pyogenes MGAS2096 spermidine/putrescine ABC transporter permease YP_600497.1 865573 D 370565 CDS YP_600498.1 94992399 4065943 866385..867161 1 NC_008023.1 spermidine/putrescine ABC transporter permease 867161 potC 4065943 potC Streptococcus pyogenes MGAS2096 spermidine/putrescine ABC transporter permease YP_600498.1 866385 D 370565 CDS YP_600499.1 94992400 4065887 867154..868227 1 NC_008023.1 spermidine/putrescine-binding protein 868227 4065887 MGAS2096_Spy0903 Streptococcus pyogenes MGAS2096 spermidine/putrescine-binding protein YP_600499.1 867154 D 370565 CDS YP_600500.1 94992401 4065888 complement(868282..868947) 1 NC_008023.1 transcriptional regulatory protein dpiA 868947 dpiA 4065888 dpiA Streptococcus pyogenes MGAS2096 transcriptional regulatory protein dpiA YP_600500.1 868282 R 370565 CDS YP_600501.1 94992402 4065889 complement(868928..869437) 1 NC_008023.1 sensor kinase dpiB 869437 4065889 MGAS2096_Spy0905 Streptococcus pyogenes MGAS2096 sensor kinase dpiB YP_600501.1 868928 R 370565 CDS YP_600502.1 94992403 4065890 complement(869407..870468) 1 NC_008023.1 sensor kinase dpiB 870468 dpiB 4065890 dpiB Streptococcus pyogenes MGAS2096 sensor kinase dpiB YP_600502.1 869407 R 370565 CDS YP_600503.1 94992404 4065891 870629..871960 1 NC_008023.1 malate-sodium symport 871960 malP 4065891 malP Streptococcus pyogenes MGAS2096 malate-sodium symport YP_600503.1 870629 D 370565 CDS YP_600504.1 94992405 4065892 872089..873156 1 NC_008023.1 NAD-dependent malic enzyme 873156 4065892 MGAS2096_Spy0908 Streptococcus pyogenes MGAS2096 NAD-dependent malic enzyme YP_600504.1 872089 D 370565 CDS YP_600505.1 94992406 4065893 complement(873238..874329) 1 NC_008023.1 Zn-dependent alcohol dehydrogenases and related dehydrogenases 874329 4065893 MGAS2096_Spy0909 Streptococcus pyogenes MGAS2096 Zn-dependent alcohol dehydrogenases and related dehydrogenases YP_600505.1 873238 R 370565 CDS YP_600506.1 94992407 4065894 874523..875254 1 NC_008023.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 875254 aphA 4065894 aphA Streptococcus pyogenes MGAS2096 acid phosphatase/phosphotransferase YP_600506.1 874523 D 370565 CDS YP_600507.1 94992408 4065895 875396..876964 1 NC_008023.1 chloride channel protein 876964 4065895 MGAS2096_Spy0911 Streptococcus pyogenes MGAS2096 chloride channel protein YP_600507.1 875396 D 370565 CDS YP_600508.1 94992409 4065896 877127..877741 1 NC_008023.1 lipase/acylhydrolase family protein 877741 4065896 MGAS2096_Spy0912 Streptococcus pyogenes MGAS2096 lipase/acylhydrolase family protein YP_600508.1 877127 D 370565 CDS YP_600509.1 94992410 4065897 877787..877900 1 NC_008023.1 hypothetical protein 877900 4065897 MGAS2096_Spy0913 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600509.1 877787 D 370565 CDS YP_600510.1 94992411 4065898 877900..879048 1 NC_008023.1 hypothetical protein 879048 4065898 MGAS2096_Spy0914 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600510.1 877900 D 370565 CDS YP_600511.1 94992412 4065899 879097..879777 1 NC_008023.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 879777 radC 4065899 radC Streptococcus pyogenes MGAS2096 DNA repair protein RadC YP_600511.1 879097 D 370565 CDS YP_600512.1 94992413 4065900 complement(879779..880474) 1 NC_008023.1 glutamine amidotransferase 880474 4065900 MGAS2096_Spy0916 Streptococcus pyogenes MGAS2096 glutamine amidotransferase YP_600512.1 879779 R 370565 CDS YP_600513.1 94992414 4065901 complement(880484..881128) 1 NC_008023.1 modulates transcription in response to the NADH/NAD(+) redox state; redox-sensing transcriptional repressor Rex 881128 4065901 MGAS2096_Spy0917 Streptococcus pyogenes MGAS2096 redox-sensing transcriptional repressor Rex YP_600513.1 880484 R 370565 CDS YP_600514.1 94992415 4065902 complement(881380..881727) 1 NC_008023.1 putative cytoplasmic protein 881727 4065902 MGAS2096_Spy0918 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600514.1 881380 R 370565 CDS YP_600515.1 94992416 4065903 complement(881717..882844) 1 NC_008023.1 bifunctional; cysteine desulfurase / selenocysteine lyase 882844 nifS2 4065903 nifS2 Streptococcus pyogenes MGAS2096 cysteine desulfurase / selenocysteine lyase YP_600515.1 881717 R 370565 CDS YP_600516.1 94992417 4065904 complement(882841..883821) 1 NC_008023.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 883821 4065904 MGAS2096_Spy0920 Streptococcus pyogenes MGAS2096 ribose-phosphate pyrophosphokinase YP_600516.1 882841 R 370565 CDS YP_600517.1 94992418 4065905 complement(883961..884539) 1 NC_008023.1 organic phosphate binding CYTH family protein 884539 4065905 MGAS2096_Spy0921 Streptococcus pyogenes MGAS2096 organic phosphate binding CYTH family protein YP_600517.1 883961 R 370565 CDS YP_600518.1 94992419 4065906 884627..884824 1 NC_008023.1 GTP pyrophosphokinase 884824 4065906 MGAS2096_Spy0922 Streptococcus pyogenes MGAS2096 GTP pyrophosphokinase YP_600518.1 884627 D 370565 CDS YP_600519.1 94992420 4065868 884860..885297 1 NC_008023.1 GTP pyrophosphokinase-like protein 885297 4065868 MGAS2096_Spy0923 Streptococcus pyogenes MGAS2096 GTP pyrophosphokinase-like protein YP_600519.1 884860 D 370565 CDS YP_600520.1 94992421 4065869 885269..886108 1 NC_008023.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 886108 ppnK 4065869 ppnK Streptococcus pyogenes MGAS2096 inorganic polyphosphate/ATP-NAD kinase YP_600520.1 885269 D 370565 CDS YP_600521.1 94992422 4065870 886184..887011 1 NC_008023.1 ribosomal large subunit pseudouridine synthase D 887011 4065870 MGAS2096_Spy0925 Streptococcus pyogenes MGAS2096 ribosomal large subunit pseudouridine synthase D YP_600521.1 886184 D 370565 CDS YP_600522.1 94992423 4065871 887015..888010 1 NC_008023.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 888010 eutD 4065871 eutD Streptococcus pyogenes MGAS2096 phosphotransacetylase YP_600522.1 887015 D 370565 CDS YP_600523.1 94992424 4065872 888076..888891 1 NC_008023.1 short-chain dehydrogenase 888891 4065872 MGAS2096_Spy0927 Streptococcus pyogenes MGAS2096 short-chain dehydrogenase YP_600523.1 888076 D 370565 CDS YP_600524.1 94992425 4065873 complement(889085..889774) 1 NC_008023.1 Na+ driven multidrug efflux pump 889774 4065873 MGAS2096_Spy0928 Streptococcus pyogenes MGAS2096 Na+ driven multidrug efflux pump YP_600524.1 889085 R 370565 CDS YP_600525.1 94992426 4065874 890200..890928 1 NC_008023.1 glycine betaine transport ATP-binding protein 890928 proV 4065874 proV Streptococcus pyogenes MGAS2096 glycine betaine transport ATP-binding protein YP_600525.1 890200 D 370565 CDS YP_600526.1 94992427 4065875 890885..892447 1 NC_008023.1 glycine betaine transport system permease / glycine betaine-binding protein 892447 4065875 MGAS2096_Spy0930 Streptococcus pyogenes MGAS2096 glycine betaine transport system permease / glycine betaine-binding protein YP_600526.1 890885 D 370565 CDS YP_600527.1 94992428 4065876 892704..893708 1 NC_008023.1 guanosine 5'-monophosphate oxidoreductase 893708 guaC 4065876 guaC Streptococcus pyogenes MGAS2096 guanosine 5'-monophosphate oxidoreductase YP_600527.1 892704 D 370565 CDS YP_600528.1 94992429 4065877 894013..894594 1 NC_008023.1 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine; xanthine phosphoribosyltransferase 894594 xpt 4065877 xpt Streptococcus pyogenes MGAS2096 xanthine phosphoribosyltransferase YP_600528.1 894013 D 370565 CDS YP_600529.1 94992430 4065878 894594..895877 1 NC_008023.1 xanthine permease 895877 4065878 MGAS2096_Spy0933 Streptococcus pyogenes MGAS2096 xanthine permease YP_600529.1 894594 D 370565 CDS YP_600530.1 94992431 4065879 complement(895941..896879) 1 NC_008023.1 Iron-sulfur cluster assembly/repair protein ApbE 896879 apbE 4065879 apbE Streptococcus pyogenes MGAS2096 Iron-sulfur cluster assembly/repair protein ApbE YP_600530.1 895941 R 370565 CDS YP_600531.1 94992432 4065880 complement(896932..897117) 1 NC_008023.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase 897117 4065880 MGAS2096_Spy0935 Streptococcus pyogenes MGAS2096 4-oxalocrotonate tautomerase YP_600531.1 896932 R 370565 CDS YP_600532.1 94992433 4065881 897255..897824 1 NC_008023.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 897824 tdk2 4065881 tdk2 Streptococcus pyogenes MGAS2096 thymidine kinase YP_600532.1 897255 D 370565 CDS YP_600533.1 94992434 4065882 897859..898938 1 NC_008023.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 898938 prfA 4065882 prfA Streptococcus pyogenes MGAS2096 peptide chain release factor 1 YP_600533.1 897859 D 370565 CDS YP_600534.1 94992435 4065883 898938..899777 1 NC_008023.1 peptide release factor-glutamine N5-methyltransferase 899777 hemK 4065883 hemK Streptococcus pyogenes MGAS2096 peptide release factor-glutamine N5-methyltransferase YP_600534.1 898938 D 370565 CDS YP_600535.1 94992436 4065884 899731..900351 1 NC_008023.1 Sua5/YciO/YrdC/YwlC family protein 900351 4065884 MGAS2096_Spy0939 Streptococcus pyogenes MGAS2096 Sua5/YciO/YrdC/YwlC family protein YP_600535.1 899731 D 370565 CDS YP_600536.1 94992437 4065885 900369..900821 1 NC_008023.1 phosphinothricin N-acetyltransferase 900821 4065885 MGAS2096_Spy0940 Streptococcus pyogenes MGAS2096 phosphinothricin N-acetyltransferase YP_600536.1 900369 D 370565 CDS YP_600537.1 94992438 4065886 900805..902067 1 NC_008023.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 902067 glyA 4065886 glyA Streptococcus pyogenes MGAS2096 serine hydroxymethyltransferase YP_600537.1 900805 D 370565 CDS YP_600538.1 94992439 4065848 902074..903051 1 NC_008023.1 hypothetical protein 903051 4065848 MGAS2096_Spy0942 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600538.1 902074 D 370565 CDS YP_600539.1 94992440 4065849 903052..903651 1 NC_008023.1 antigen-like protein 903651 4065849 MGAS2096_Spy0943 Streptococcus pyogenes MGAS2096 antigen-like protein YP_600539.1 903052 D 370565 CDS YP_600540.1 94992441 4065850 903661..905379 1 NC_008023.1 multidrug ABC transporter permease/ATP-binding protein 905379 4065850 MGAS2096_Spy0944 Streptococcus pyogenes MGAS2096 multidrug ABC transporter permease/ATP-binding protein YP_600540.1 903661 D 370565 CDS YP_600541.1 94992442 4065851 905382..907109 1 NC_008023.1 multidrug/protein/lipid ABC transporter family ATP-binding and permease 907109 4065851 MGAS2096_Spy0945 Streptococcus pyogenes MGAS2096 multidrug/protein/lipid ABC transporter family ATP-binding and permease YP_600541.1 905382 D 370565 CDS YP_600542.1 94992443 4065852 907350..908720 1 NC_008023.1 NADH oxidase H2O-forming 908720 nox 4065852 nox Streptococcus pyogenes MGAS2096 NADH oxidase H2O-forming YP_600542.1 907350 D 370565 CDS YP_600543.1 94992444 4065853 complement(908879..909862) 1 NC_008023.1 Converts (S)-lactate and NAD(+) to pyruvate and NADH; L-lactate dehydrogenase 909862 ldh 4065853 ldh Streptococcus pyogenes MGAS2096 L-lactate dehydrogenase YP_600543.1 908879 R 370565 CDS YP_600544.1 94992445 4065854 910053..912539 1 NC_008023.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 912539 gyrA 4065854 gyrA Streptococcus pyogenes MGAS2096 DNA gyrase subunit A YP_600544.1 910053 D 370565 CDS YP_600545.1 94992446 4065855 912559..913308 1 NC_008023.1 sortase 913308 4065855 MGAS2096_Spy0949 Streptococcus pyogenes MGAS2096 sortase YP_600545.1 912559 D 370565 CDS YP_600546.1 94992447 4065856 913388..913804 1 NC_008023.1 glyoxalase family protein 913804 4065856 MGAS2096_Spy0950 Streptococcus pyogenes MGAS2096 glyoxalase family protein YP_600546.1 913388 D 370565 CDS YP_600547.1 94992448 4065857 914279..914410 1 NC_008023.1 hypothetical protein 914410 4065857 MGAS2096_Spy0951 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600547.1 914279 D 370565 CDS YP_600548.1 94992449 4065858 914361..914858 1 NC_008023.1 hypothetical protein 914858 4065858 MGAS2096_Spy0952 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600548.1 914361 D 370565 CDS YP_600549.1 94992450 4065859 complement(914908..915819) 1 NC_008023.1 diacylglycerol kinase family protein 915819 4065859 MGAS2096_Spy0953 Streptococcus pyogenes MGAS2096 diacylglycerol kinase family protein YP_600549.1 914908 R 370565 CDS YP_600550.1 94992451 4065860 complement(915936..916586) 1 NC_008023.1 hemolysin III homolog; hypothetical protein 916586 4065860 MGAS2096_Spy0954 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600550.1 915936 R 370565 CDS YP_600551.1 94992452 4065861 complement(916583..917023) 1 NC_008023.1 putative cytoplasmic protein 917023 4065861 MGAS2096_Spy0955 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600551.1 916583 R 370565 CDS YP_600552.1 94992453 4065862 917242..918090 1 NC_008023.1 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc); ribosomal biogenesis GTPase 918090 rbgA 4065862 rbgA Streptococcus pyogenes MGAS2096 ribosomal biogenesis GTPase YP_600552.1 917242 D 370565 CDS YP_600553.1 94992454 4065863 918080..918871 1 NC_008023.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 918871 rnhB 4065863 rnhB Streptococcus pyogenes MGAS2096 ribonuclease HII YP_600553.1 918080 D 370565 CDS YP_600554.1 94992455 4065864 918936..919772 1 NC_008023.1 DNA processing protein 919772 smf 4065864 smf Streptococcus pyogenes MGAS2096 DNA processing protein YP_600554.1 918936 D 370565 CDS YP_600555.1 94992456 4065865 919879..922008 1 NC_008023.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 922008 4065865 MGAS2096_Spy0959 Streptococcus pyogenes MGAS2096 DNA topoisomerase I YP_600555.1 919879 D 370565 CDS YP_600556.1 94992457 4065866 complement(922083..922565) 1 NC_008023.1 LysR family transcriptional regulator 922565 4065866 MGAS2096_Spy0960 Streptococcus pyogenes MGAS2096 LysR family transcriptional regulator YP_600556.1 922083 R 370565 CDS YP_600557.1 94992458 4065867 complement(922572..922694) 1 NC_008023.1 LysR family transcriptional regulator 922694 4065867 MGAS2096_Spy0961 Streptococcus pyogenes MGAS2096 LysR family transcriptional regulator YP_600557.1 922572 R 370565 CDS YP_600558.1 94992459 4065829 922980..923546 1 NC_008023.1 hypothetical protein 923546 4065829 MGAS2096_Spy0962 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600558.1 922980 D 370565 CDS YP_600559.1 94992460 4065830 923558..924553 1 NC_008023.1 catalyzes the formation of pyruvate from lactate; D-lactate dehydrogenase 924553 ddh 4065830 ddh Streptococcus pyogenes MGAS2096 D-lactate dehydrogenase YP_600559.1 923558 D 370565 CDS YP_600560.1 94992461 4065831 924658..925323 1 NC_008023.1 hypothetical protein 925323 satD 4065831 satD Streptococcus pyogenes MGAS2096 hypothetical protein YP_600560.1 924658 D 370565 CDS YP_600561.1 94992462 4065832 925316..926032 1 NC_008023.1 hypothetical protein 926032 satE 4065832 satE Streptococcus pyogenes MGAS2096 hypothetical protein YP_600561.1 925316 D 370565 CDS YP_600562.1 94992463 4065833 926033..927541 1 NC_008023.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine; tRNA (uracil-5-)-methyltransferase Gid 927541 gid 4065833 gid Streptococcus pyogenes MGAS2096 tRNA (uracil-5-)-methyltransferase Gid YP_600562.1 926033 D 370565 CDS YP_600563.1 94992464 4065834 927694..927966 1 NC_008023.1 oxaloacetate decarboxylase subunit alpha 927966 4065834 MGAS2096_Spy0967 Streptococcus pyogenes MGAS2096 oxaloacetate decarboxylase subunit alpha YP_600563.1 927694 D 370565 CDS YP_600564.1 94992465 4065835 928146..929114 1 NC_008023.1 oxaloacetate decarboxylase subunit alpha 929114 oadA1 4065835 oadA1 Streptococcus pyogenes MGAS2096 oxaloacetate decarboxylase subunit alpha YP_600564.1 928146 D 370565 CDS YP_600565.1 94992466 4065836 complement(929225..930277) 1 NC_008023.1 (citrate (pro-3S)-lyase) ligase 930277 citC 4065836 citC Streptococcus pyogenes MGAS2096 (citrate (pro-3S)-lyase) ligase YP_600565.1 929225 R 370565 CDS YP_600566.1 94992467 4065837 complement(930366..930848) 1 NC_008023.1 hypothetical protein 930848 4065837 MGAS2096_Spy0970 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600566.1 930366 R 370565 CDS YP_600567.1 94992468 4065838 931327..931431 1 NC_008023.1 hypothetical protein 931431 4065838 MGAS2096_Spy0971 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600567.1 931327 D 370565 CDS YP_600568.1 94992469 4065839 complement(931542..932648) 1 NC_008023.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS; site-specific tyrosine recombinase XerS 932648 xerS 4065839 xerS Streptococcus pyogenes MGAS2096 site-specific tyrosine recombinase XerS YP_600568.1 931542 R 370565 CDS YP_600569.1 94992470 4065840 933082..933555 1 NC_008023.1 phage transcriptional repressor 933555 4065840 MGAS2096_Spy0973 Streptococcus pyogenes MGAS2096 phage transcriptional repressor YP_600569.1 933082 D 370565 CDS YP_600570.1 94992471 4065841 complement(933914..935482) 1 NC_008023.1 signal recognition particle subunit FFH/SRP54 935482 ffh 4065841 ffh Streptococcus pyogenes MGAS2096 signal recognition particle subunit FFH/SRP54 YP_600570.1 933914 R 370565 CDS YP_600571.1 94992472 4065842 complement(935491..935832) 1 NC_008023.1 putative DNA-binding protein 935832 ylxM 4065842 ylxM Streptococcus pyogenes MGAS2096 putative DNA-binding protein YP_600571.1 935491 R 370565 CDS YP_600572.1 94992473 4065843 complement(935932..936645) 1 NC_008023.1 GntR family transcriptional regulator 936645 4065843 MGAS2096_Spy0976 Streptococcus pyogenes MGAS2096 GntR family transcriptional regulator YP_600572.1 935932 R 370565 CDS YP_600573.1 94992474 4065844 complement(936701..938134) 1 NC_008023.1 hypothetical protein 938134 4065844 MGAS2096_Spy0977 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600573.1 936701 R 370565 CDS YP_600574.1 94992475 4065845 938301..939863 1 NC_008023.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 939863 guaA 4065845 guaA Streptococcus pyogenes MGAS2096 GMP synthase YP_600574.1 938301 D 370565 CDS YP_600575.1 94992476 4065846 complement(939905..941128) 1 NC_008023.1 bifunctional; UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase / UDP-N-acetylmuramoylpentapeptide-lysine N(6)-seryltransferase 941128 4065846 MGAS2096_Spy0979 Streptococcus pyogenes MGAS2096 UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase / UDP-N-acetylmuramoylpentapeptide-lysine N(6)-seryltransferase YP_600575.1 939905 R 370565 CDS YP_600576.1 94992477 4065847 complement(941492..943072) 1 NC_008023.1 ABC transporter ATP-binding protein 943072 4065847 MGAS2096_Spy0980 Streptococcus pyogenes MGAS2096 ABC transporter ATP-binding protein YP_600576.1 941492 R 370565 CDS YP_600577.1 94992478 4065809 complement(943170..943727) 1 NC_008023.1 hypothetical protein 943727 pdxK 4065809 pdxK Streptococcus pyogenes MGAS2096 hypothetical protein YP_600577.1 943170 R 370565 CDS YP_600578.1 94992479 4065810 complement(943705..944571) 1 NC_008023.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase 944571 4065810 MGAS2096_Spy0982 Streptococcus pyogenes MGAS2096 pyridoxamine kinase YP_600578.1 943705 R 370565 CDS YP_600579.1 94992480 4065811 944661..945827 1 NC_008023.1 GntR family transcriptional regulator 945827 4065811 MGAS2096_Spy0983 Streptococcus pyogenes MGAS2096 GntR family transcriptional regulator YP_600579.1 944661 D 370565 CDS YP_600580.1 94992481 4065812 complement(946335..946691) 1 NC_008023.1 anaerobic ribonucleoside-triphosphate reductase 946691 rnhB 4065812 rnhB Streptococcus pyogenes MGAS2096 anaerobic ribonucleoside-triphosphate reductase YP_600580.1 946335 R 370565 CDS YP_600581.1 94992482 4065813 complement(947013..948590) 1 NC_008023.1 cardiolipin synthetase 948590 4065813 MGAS2096_Spy0985 Streptococcus pyogenes MGAS2096 cardiolipin synthetase YP_600581.1 947013 R 370565 CDS YP_600582.1 94992483 4065814 complement(948675..950345) 1 NC_008023.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase 950345 fhs1 4065814 fhs1 Streptococcus pyogenes MGAS2096 formate--tetrahydrofolate ligase YP_600582.1 948675 R 370565 CDS YP_600583.1 94992484 4065815 complement(950473..951492) 1 NC_008023.1 lipoate-protein ligase A 951492 lplA 4065815 lplA Streptococcus pyogenes MGAS2096 lipoate-protein ligase A YP_600583.1 950473 R 370565 CDS YP_600584.1 94992485 4065816 complement(951539..952420) 1 NC_008023.1 SIR2 family protein 952420 4065816 MGAS2096_Spy0988 Streptococcus pyogenes MGAS2096 SIR2 family protein YP_600584.1 951539 R 370565 CDS YP_600585.1 94992486 4065817 complement(952413..953225) 1 NC_008023.1 hypothetical protein 953225 4065817 MGAS2096_Spy0989 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600585.1 952413 R 370565 CDS YP_600586.1 94992487 4065818 complement(953218..953550) 1 NC_008023.1 glycine cleavage system H protein 953550 4065818 MGAS2096_Spy0990 Streptococcus pyogenes MGAS2096 glycine cleavage system H protein YP_600586.1 953218 R 370565 CDS YP_600587.1 94992488 4065819 complement(953592..954590) 1 NC_008023.1 luciferase-like monooxygenase 954590 4065819 MGAS2096_Spy0991 Streptococcus pyogenes MGAS2096 luciferase-like monooxygenase YP_600587.1 953592 R 370565 CDS YP_600588.1 94992489 4065820 complement(954587..955786) 1 NC_008023.1 NADH-dependent flavin oxidoreductase yqiG 955786 4065820 MGAS2096_Spy0992 Streptococcus pyogenes MGAS2096 NADH-dependent flavin oxidoreductase yqiG YP_600588.1 954587 R 370565 CDS YP_600589.1 94992490 4065821 complement(955783..956634) 1 NC_008023.1 lipoate-protein ligase A 956634 4065821 MGAS2096_Spy0993 Streptococcus pyogenes MGAS2096 lipoate-protein ligase A YP_600589.1 955783 R 370565 CDS YP_600590.1 94992491 4065822 956814..957506 1 NC_008023.1 phosphopantothenate--cysteine ligase 957506 dpfB 4065822 dpfB Streptococcus pyogenes MGAS2096 phosphopantothenate--cysteine ligase YP_600590.1 956814 D 370565 CDS YP_600591.1 94992492 4065823 957499..958044 1 NC_008023.1 decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.; phosphopantothenoylcysteine decarboxylase 958044 dfp 4065823 dfp Streptococcus pyogenes MGAS2096 phosphopantothenoylcysteine decarboxylase YP_600591.1 957499 D 370565 CDS YP_600592.1 94992493 4065824 958090..958665 1 NC_008023.1 integral membrane protein 958665 4065824 MGAS2096_Spy0996 Streptococcus pyogenes MGAS2096 integral membrane protein YP_600592.1 958090 D 370565 CDS YP_600593.1 94992494 4065825 958959..960677 1 NC_008023.1 bifunctional; phosphoglucomutase/phosphomannomutase 960677 pgmA 4065825 pgmA Streptococcus pyogenes MGAS2096 phosphoglucomutase/phosphomannomutase YP_600593.1 958959 D 370565 CDS YP_600594.1 94992495 4065826 complement(960890..961858) 1 NC_008023.1 nucleoside transport system permease 961858 4065826 MGAS2096_Spy0998 Streptococcus pyogenes MGAS2096 nucleoside transport system permease YP_600594.1 960890 R 370565 CDS YP_600595.1 94992496 4065827 complement(961848..962939) 1 NC_008023.1 nucleoside transport system permease 962939 4065827 MGAS2096_Spy0999 Streptococcus pyogenes MGAS2096 nucleoside transport system permease YP_600595.1 961848 R 370565 CDS YP_600596.1 94992497 4065828 complement(962905..964455) 1 NC_008023.1 nucleoside transport ATP-binding protein 964455 4065828 MGAS2096_Spy1000 Streptococcus pyogenes MGAS2096 nucleoside transport ATP-binding protein YP_600596.1 962905 R 370565 CDS YP_600597.1 94992498 4065020 complement(964576..965628) 1 NC_008023.1 nucleoside-binding protein 965628 4065020 MGAS2096_Spy1001 Streptococcus pyogenes MGAS2096 nucleoside-binding protein YP_600597.1 964576 R 370565 CDS YP_600598.1 94992499 4065021 complement(965722..966111) 1 NC_008023.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 966111 cdd 4065021 cdd Streptococcus pyogenes MGAS2096 cytidine deaminase YP_600598.1 965722 R 370565 CDS YP_600599.1 94992500 4065022 complement(966762..967388) 1 NC_008023.1 16S rRNA m(2)G 1207 methyltransferase 967388 4065022 MGAS2096_Spy1003 Streptococcus pyogenes MGAS2096 16S rRNA m(2)G 1207 methyltransferase YP_600599.1 966762 R 370565 CDS YP_600600.1 94992501 4065023 967623..968543 1 NC_008023.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 968543 coaA 4065023 coaA Streptococcus pyogenes MGAS2096 pantothenate kinase YP_600600.1 967623 D 370565 CDS YP_600601.2 162139130 4065024 968612..968845 1 NC_008023.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 968845 rpsT 4065024 rpsT Streptococcus pyogenes MGAS2096 30S ribosomal protein S20 YP_600601.2 968612 D 370565 CDS YP_600602.1 94992503 4065025 complement(968970..970280) 1 NC_008023.1 sensor protein ciaH 970280 ciaH 4065025 ciaH Streptococcus pyogenes MGAS2096 sensor protein ciaH YP_600602.1 968970 R 370565 CDS YP_600603.1 94992504 4065026 complement(970273..970947) 1 NC_008023.1 transcriptional regulatory protein ciaR 970947 ciaR 4065026 ciaR Streptococcus pyogenes MGAS2096 transcriptional regulatory protein ciaR YP_600603.1 970273 R 370565 CDS YP_600604.1 94992505 4065027 complement(971293..973890) 1 NC_008023.1 bifunctional; lysyl aminopeptidase / alanine aminopeptidase 973890 pepN 4065027 pepN Streptococcus pyogenes MGAS2096 lysyl aminopeptidase / alanine aminopeptidase YP_600604.1 971293 R 370565 CDS YP_600605.1 94992506 4065028 complement(973887..974081) 1 NC_008023.1 hypothetical protein 974081 4065028 MGAS2096_Spy1009 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600605.1 973887 R 370565 CDS YP_600606.1 94992507 4065029 complement(974035..974688) 1 NC_008023.1 phosphate transporter PhoU 974688 phoU 4065029 phoU Streptococcus pyogenes MGAS2096 phosphate transporter PhoU YP_600606.1 974035 R 370565 CDS YP_600607.1 94992508 4065030 complement(974756..975517) 1 NC_008023.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 975517 pstB 4065030 pstB Streptococcus pyogenes MGAS2096 phosphate transporter ATP-binding protein YP_600607.1 974756 R 370565 CDS YP_600608.1 94992509 4065031 complement(975527..976330) 1 NC_008023.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 976330 pstB2 4065031 pstB2 Streptococcus pyogenes MGAS2096 phosphate transporter ATP-binding protein YP_600608.1 975527 R 370565 CDS YP_600609.1 94992510 4065032 complement(976346..977233) 1 NC_008023.1 phosphate ABC transporter permease 977233 pstA 4065032 pstA Streptococcus pyogenes MGAS2096 phosphate ABC transporter permease YP_600609.1 976346 R 370565 CDS YP_600610.1 94992511 4065033 complement(977223..978158) 1 NC_008023.1 phosphate ABC transporter permease 978158 pstC 4065033 pstC Streptococcus pyogenes MGAS2096 phosphate ABC transporter permease YP_600610.1 977223 R 370565 CDS YP_600611.1 94992512 4065034 complement(978169..979035) 1 NC_008023.1 phosphate-binding protein 979035 pstS 4065034 pstS Streptococcus pyogenes MGAS2096 phosphate-binding protein YP_600611.1 978169 R 370565 CDS YP_600612.1 94992513 4065035 complement(979174..980484) 1 NC_008023.1 putative 23S rRNA m(5)C methyltransferase 980484 4065035 MGAS2096_Spy1016 Streptococcus pyogenes MGAS2096 putative 23S rRNA m(5)C methyltransferase YP_600612.1 979174 R 370565 CDS YP_600613.1 94992514 4065036 complement(980487..981296) 1 NC_008023.1 myo-inositol-1(or 4)-monophosphatase 981296 4065036 MGAS2096_Spy1017 Streptococcus pyogenes MGAS2096 myo-inositol-1(or 4)-monophosphatase YP_600613.1 980487 R 370565 CDS YP_600614.1 94992515 4065037 complement(981265..981555) 1 NC_008023.1 hypothetical protein 981555 4065037 MGAS2096_Spy1018 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600614.1 981265 R 370565 CDS YP_600615.1 94992516 4065038 complement(981545..981949) 1 NC_008023.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx 981949 spxA 4065038 spxA Streptococcus pyogenes MGAS2096 transcriptional regulator Spx YP_600615.1 981545 R 370565 CDS YP_600616.1 94992517 4064805 complement(981992..982924) 1 NC_008023.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 982924 mreA 4064805 mreA Streptococcus pyogenes MGAS2096 bifunctional riboflavin kinase/FMN adenylyltransferase YP_600616.1 981992 R 370565 CDS YP_600617.1 94992518 4064806 complement(982953..983837) 1 NC_008023.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 983837 truB 4064806 truB Streptococcus pyogenes MGAS2096 tRNA pseudouridine synthase B YP_600617.1 982953 R 370565 CDS YP_600618.1 94992519 4064807 complement(983953..985293) 1 NC_008023.1 hypothetical protein 985293 4064807 MGAS2096_Spy1022 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600618.1 983953 R 370565 CDS YP_600619.1 94992520 4064808 complement(985390..986346) 1 NC_008023.1 integral membrane protein 986346 4064808 MGAS2096_Spy1023 Streptococcus pyogenes MGAS2096 integral membrane protein YP_600619.1 985390 R 370565 CDS YP_600620.1 94992521 4064809 complement(986357..986953) 1 NC_008023.1 type I restriction-modification system specificity subunit 986953 4064809 MGAS2096_Spy1024 Streptococcus pyogenes MGAS2096 type I restriction-modification system specificity subunit YP_600620.1 986357 R 370565 CDS YP_600621.1 94992522 4064810 complement(987045..989681) 1 NC_008023.1 ABC transporter permease 989681 4064810 MGAS2096_Spy1025 Streptococcus pyogenes MGAS2096 ABC transporter permease YP_600621.1 987045 R 370565 CDS YP_600622.1 94992523 4064811 complement(989696..990409) 1 NC_008023.1 ABC transporter ATP-binding protein 990409 4064811 MGAS2096_Spy1026 Streptococcus pyogenes MGAS2096 ABC transporter ATP-binding protein YP_600622.1 989696 R 370565 CDS YP_600623.1 94992524 4064812 990515..991057 1 NC_008023.1 TetR family transcriptional regulator 991057 4064812 MGAS2096_Spy1027 Streptococcus pyogenes MGAS2096 TetR family transcriptional regulator YP_600623.1 990515 D 370565 CDS YP_600624.1 94992525 4064813 complement(991054..991197) 1 NC_008023.1 hypothetical protein 991197 4064813 MGAS2096_Spy1028 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600624.1 991054 R 370565 CDS YP_600625.1 94992526 4064814 complement(991200..991841) 1 NC_008023.1 NAD-dependent K+ or Na(+) uptake system component /GntR family transcriptional regulator 991841 4064814 MGAS2096_Spy1029 Streptococcus pyogenes MGAS2096 NAD-dependent K+ or Na(+) uptake system component /GntR family transcriptional regulator YP_600625.1 991200 R 370565 CDS YP_600626.1 94992527 4064815 complement(992004..992495) 1 NC_008023.1 Gls24 family general stress protein 992495 4064815 MGAS2096_Spy1030 Streptococcus pyogenes MGAS2096 Gls24 family general stress protein YP_600626.1 992004 R 370565 CDS YP_600627.1 94992528 4064816 complement(992503..992703) 1 NC_008023.1 hypothetical protein 992703 4064816 MGAS2096_Spy1031 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600627.1 992503 R 370565 CDS YP_600628.1 94992529 4064817 complement(992744..993283) 1 NC_008023.1 Gls24 family general stress protein 993283 4064817 MGAS2096_Spy1032 Streptococcus pyogenes MGAS2096 Gls24 family general stress protein YP_600628.1 992744 R 370565 CDS YP_600629.1 94992530 4064818 complement(993296..993484) 1 NC_008023.1 small integral membrane protein 993484 4064818 MGAS2096_Spy1033 Streptococcus pyogenes MGAS2096 small integral membrane protein YP_600629.1 993296 R 370565 CDS YP_600630.1 94992531 4064819 complement(993495..994106) 1 NC_008023.1 hypothetical protein 994106 4064819 MGAS2096_Spy1034 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600630.1 993495 R 370565 CDS YP_600631.1 94992532 4064820 complement(994143..994391) 1 NC_008023.1 integral membrane protein 994391 4064820 MGAS2096_Spy1035 Streptococcus pyogenes MGAS2096 integral membrane protein YP_600631.1 994143 R 370565 CDS YP_600632.1 94992533 4064821 complement(994755..997073) 1 NC_008023.1 DNA helicase II 997073 pcrA 4064821 pcrA Streptococcus pyogenes MGAS2096 DNA helicase II YP_600632.1 994755 R 370565 CDS YP_600633.1 94992534 4064822 complement(997439..997609) 1 NC_008023.1 hypothetical protein 997609 4064822 MGAS2096_Spy1038 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600633.1 997439 R 370565 CDS YP_600634.1 94992535 4064823 997600..998922 1 NC_008023.1 Na(+)-linked D-alanine glycine permease 998922 4064823 MGAS2096_Spy1037 Streptococcus pyogenes MGAS2096 Na(+)-linked D-alanine glycine permease YP_600634.1 997600 D 370565 CDS YP_600635.1 94992536 4064824 999042..999329 1 NC_008023.1 cobalt-zinc-cadmium resistance protein czcD 999329 4064824 MGAS2096_Spy1039 Streptococcus pyogenes MGAS2096 cobalt-zinc-cadmium resistance protein czcD YP_600635.1 999042 D 370565 CDS YP_600636.1 94992537 4065264 999317..1000276 1 NC_008023.1 cobalt-zinc-cadmium resistance protein czcD 1000276 4065264 MGAS2096_Spy1040 Streptococcus pyogenes MGAS2096 cobalt-zinc-cadmium resistance protein czcD YP_600636.1 999317 D 370565 CDS YP_600637.1 94992538 4065265 complement(1000646..1001419) 1 NC_008023.1 cAMP factor 1001419 cfa 4065265 cfa Streptococcus pyogenes MGAS2096 cAMP factor YP_600637.1 1000646 R 370565 CDS YP_600638.1 94992539 4065266 complement(1001789..1002625) 1 NC_008023.1 histidine-binding protein 1002625 4065266 MGAS2096_Spy1042 Streptococcus pyogenes MGAS2096 histidine-binding protein YP_600638.1 1001789 R 370565 CDS YP_600639.1 94992540 4065267 complement(1002641..1003270) 1 NC_008023.1 histidine transport ATP-binding protein hisP 1003270 4065267 MGAS2096_Spy1043 Streptococcus pyogenes MGAS2096 histidine transport ATP-binding protein hisP YP_600639.1 1002641 R 370565 CDS YP_600640.1 94992541 4065268 complement(1003280..1003921) 1 NC_008023.1 histidine transport system permease hisM 1003921 4065268 MGAS2096_Spy1044 Streptococcus pyogenes MGAS2096 histidine transport system permease hisM YP_600640.1 1003280 R 370565 CDS YP_600641.1 94992542 4065269 complement(1004027..1004362) 1 NC_008023.1 PhnA protein 1004362 4065269 MGAS2096_Spy1045 Streptococcus pyogenes MGAS2096 PhnA protein YP_600641.1 1004027 R 370565 CDS YP_600642.1 94992543 4065270 complement(1004544..1006358) 1 NC_008023.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 1006358 glmS 4065270 glmS Streptococcus pyogenes MGAS2096 glucosamine--fructose-6-phosphate aminotransferase YP_600642.1 1004544 R 370565 CDS YP_600643.1 94992544 4065271 complement(1006534..1007091) 1 NC_008023.1 Signal peptidase I 1007091 sipC 4065271 sipC Streptococcus pyogenes MGAS2096 Signal peptidase I YP_600643.1 1006534 R 370565 CDS YP_600644.1 94992545 4065272 complement(1007309..1008811) 1 NC_008023.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1008811 pyk 4065272 pyk Streptococcus pyogenes MGAS2096 pyruvate kinase YP_600644.1 1007309 R 370565 CDS YP_600645.1 94992546 4065273 complement(1008874..1009887) 1 NC_008023.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 1009887 pfk 4065273 pfk Streptococcus pyogenes MGAS2096 6-phosphofructokinase YP_600645.1 1008874 R 370565 CDS YP_600646.1 94992547 4065274 complement(1009967..1013077) 1 NC_008023.1 Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria.; DNA polymerase III DnaE 1013077 dnaE 4065274 dnaE Streptococcus pyogenes MGAS2096 DNA polymerase III DnaE YP_600646.1 1009967 R 370565 CDS YP_600647.1 94992548 4065275 1013172..1013633 1 NC_008023.1 GntR family transcriptional regulator 1013633 4065275 MGAS2096_Spy1051 Streptococcus pyogenes MGAS2096 GntR family transcriptional regulator YP_600647.1 1013172 D 370565 CDS YP_600648.1 94992549 4065276 1013633..1014331 1 NC_008023.1 ABC transporter ATP-binding protein 1014331 4065276 MGAS2096_Spy1052 Streptococcus pyogenes MGAS2096 ABC transporter ATP-binding protein YP_600648.1 1013633 D 370565 CDS YP_600649.1 94992550 4065277 1014341..1015126 1 NC_008023.1 ABC transporter permease 1015126 4065277 MGAS2096_Spy1053 Streptococcus pyogenes MGAS2096 ABC transporter permease YP_600649.1 1014341 D 370565 CDS YP_600650.1 94992551 4065278 complement(1015259..1015873) 1 NC_008023.1 putative membrane-associated alkaline phosphatase 1015873 4065278 MGAS2096_Spy1054 Streptococcus pyogenes MGAS2096 putative membrane-associated alkaline phosphatase YP_600650.1 1015259 R 370565 CDS YP_600651.1 94992552 4065279 1016383..1016496 1 NC_008023.1 phage protein 1016496 4065279 MGAS2096_Spy1055 Streptococcus pyogenes MGAS2096 phage protein YP_600651.1 1016383 D 370565 CDS YP_600652.1 94992553 4065280 1016614..1017234 1 NC_008023.1 phage protein 1017234 4065280 MGAS2096_Spy1056 Streptococcus pyogenes MGAS2096 phage protein YP_600652.1 1016614 D 370565 CDS YP_600653.1 94992554 4065281 complement(1017491..1019755) 1 NC_008023.1 maltodextrin phosphorylase 1019755 glgP 4065281 glgP Streptococcus pyogenes MGAS2096 maltodextrin phosphorylase YP_600653.1 1017491 R 370565 CDS YP_600654.1 94992555 4065282 complement(1019790..1020530) 1 NC_008023.1 4-alpha-glucanotransferase 1020530 malM 4065282 malM Streptococcus pyogenes MGAS2096 4-alpha-glucanotransferase YP_600654.1 1019790 R 370565 CDS YP_600655.1 94992556 4064674 complement(1020472..1021059) 1 NC_008023.1 4-alpha-glucanotransferase 1021059 4064674 MGAS2096_Spy1059 Streptococcus pyogenes MGAS2096 4-alpha-glucanotransferase YP_600655.1 1020472 R 370565 CDS YP_600656.1 94992557 4064675 complement(1021395..1022489) 1 NC_008023.1 LacI family transcriptional regulator 1022489 malR 4064675 malR Streptococcus pyogenes MGAS2096 LacI family transcriptional regulator YP_600656.1 1021395 R 370565 CDS YP_600657.1 94992558 4064676 1022658..1023905 1 NC_008023.1 maltose/maltodextrin-binding protein 1023905 malX 4064676 malX Streptococcus pyogenes MGAS2096 maltose/maltodextrin-binding protein YP_600657.1 1022658 D 370565 CDS YP_600658.1 94992559 4064677 1024178..1025539 1 NC_008023.1 maltodextrin transport system permease malC 1025539 malC 4064677 malC Streptococcus pyogenes MGAS2096 maltodextrin transport system permease malC YP_600658.1 1024178 D 370565 CDS YP_600659.1 94992560 4064678 1025539..1026375 1 NC_008023.1 maltose transport system permease malG 1026375 malD 4064678 malD Streptococcus pyogenes MGAS2096 maltose transport system permease malG YP_600659.1 1025539 D 370565 CDS YP_600660.1 94992561 4064679 complement(1026377..1026538) 1 NC_008023.1 hypothetical protein 1026538 4064679 MGAS2096_Spy1064 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600660.1 1026377 R 370565 CDS YP_600661.1 94992562 4064680 1026556..1026825 1 NC_008023.1 transposase 1026825 4064680 MGAS2096_Spy1065 Streptococcus pyogenes MGAS2096 transposase YP_600661.1 1026556 D 370565 CDS YP_600662.1 94992563 4064681 1026749..1027336 1 NC_008023.1 transposase 1027336 4064681 MGAS2096_Spy1066 Streptococcus pyogenes MGAS2096 transposase YP_600662.1 1026749 D 370565 CDS YP_600663.1 94992564 4064682 1027561..1027785 1 NC_008023.1 transposase 1027785 4064682 MGAS2096_Spy1067 Streptococcus pyogenes MGAS2096 transposase YP_600663.1 1027561 D 370565 CDS YP_600664.1 94992565 4064683 complement(1027850..1028833) 1 NC_008023.1 esterase 1028833 4064683 MGAS2096_Spy1068 Streptococcus pyogenes MGAS2096 esterase YP_600664.1 1027850 R 370565 CDS YP_600665.1 94992566 4064684 complement(1028864..1030114) 1 NC_008023.1 protein dltD precursor 1030114 dltD 4064684 dltD Streptococcus pyogenes MGAS2096 protein dltD precursor YP_600665.1 1028864 R 370565 CDS YP_600666.1 94992567 4064685 complement(1030107..1030346) 1 NC_008023.1 D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 2 1030346 4064685 MGAS2096_Spy1070 Streptococcus pyogenes MGAS2096 D-alanine--poly(phosphoribitol) ligase subunit 2 YP_600666.1 1030107 R 370565 CDS YP_600667.1 94992568 4064686 complement(1030364..1031620) 1 NC_008023.1 protein dltB 1031620 4064686 MGAS2096_Spy1071 Streptococcus pyogenes MGAS2096 protein dltB YP_600667.1 1030364 R 370565 CDS YP_600668.1 94992569 4064687 complement(1031617..1032216) 1 NC_008023.1 D-alanine-activating enzyme 1032216 4064687 MGAS2096_Spy1072 Streptococcus pyogenes MGAS2096 D-alanine-activating enzyme YP_600668.1 1031617 R 370565 CDS YP_600669.1 94992570 4064688 complement(1032302..1033156) 1 NC_008023.1 D-alanine-activating enzyme 1033156 dltA 4064688 dltA Streptococcus pyogenes MGAS2096 D-alanine-activating enzyme YP_600669.1 1032302 R 370565 CDS YP_600670.1 94992571 4064689 complement(1033168..1033311) 1 NC_008023.1 hypothetical protein 1033311 4064689 MGAS2096_Spy1074 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600670.1 1033168 R 370565 CDS YP_600671.1 94992572 4064690 complement(1033575..1035566) 1 NC_008023.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 1035566 uvrB 4064690 uvrB Streptococcus pyogenes MGAS2096 excinuclease ABC subunit B YP_600671.1 1033575 R 370565 CDS YP_600672.1 94992573 4064691 1035759..1037933 1 NC_008023.1 glutamine-binding protein / glutamine transport system permease glnP 1037933 glnH 4064691 glnH Streptococcus pyogenes MGAS2096 glutamine-binding protein / glutamine transport system permease glnP YP_600672.1 1035759 D 370565 CDS YP_600673.1 94992574 4064692 1037933..1038673 1 NC_008023.1 glutamine transport ATP-binding protein glnQ 1038673 glnQ2 4064692 glnQ2 Streptococcus pyogenes MGAS2096 glutamine transport ATP-binding protein glnQ YP_600673.1 1037933 D 370565 CDS YP_600674.1 94992575 4064693 1038831..1040318 1 NC_008023.1 transposase 1040318 4064693 MGAS2096_Spy1078 Streptococcus pyogenes MGAS2096 transposase YP_600674.1 1038831 D 370565 CDS YP_600675.1 94992576 4066346 complement(1040367..1040519) 1 NC_008023.1 hypothetical protein 1040519 4066346 MGAS2096_Spy1079 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600675.1 1040367 R 370565 CDS YP_600676.1 94992577 4066347 complement(1040516..1041895) 1 NC_008023.1 PTS system cellobiose-specific transporter subunit IIC 1041895 4066347 MGAS2096_Spy1080 Streptococcus pyogenes MGAS2096 PTS system cellobiose-specific transporter subunit IIC YP_600676.1 1040516 R 370565 CDS YP_600677.1 94992578 4066348 complement(1042073..1042522) 1 NC_008023.1 hypothetical protein 1042522 4066348 MGAS2096_Spy1081 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600677.1 1042073 R 370565 CDS YP_600678.1 94992579 4066349 complement(1042519..1042854) 1 NC_008023.1 PTS system cellobiose-specific transporter subunit IIA 1042854 4066349 MGAS2096_Spy1082 Streptococcus pyogenes MGAS2096 PTS system cellobiose-specific transporter subunit IIA YP_600678.1 1042519 R 370565 CDS YP_600679.1 94992580 4066350 complement(1042857..1043198) 1 NC_008023.1 PTS system cellobiose-specific transporter subunit IIB 1043198 4066350 MGAS2096_Spy1083 Streptococcus pyogenes MGAS2096 PTS system cellobiose-specific transporter subunit IIB YP_600679.1 1042857 R 370565 CDS YP_600680.1 94992581 4066351 complement(1043191..1045185) 1 NC_008023.1 BigG family transcription antiterminator / PTS system, mannitol (Cryptic)-specific IIA component 1045185 4066351 MGAS2096_Spy1084 Streptococcus pyogenes MGAS2096 BigG family transcription antiterminator / PTS system, mannitol (Cryptic)-specific IIA component YP_600680.1 1043191 R 370565 CDS YP_600681.1 94992582 4066352 complement(1045291..1046349) 1 NC_008023.1 outer surface protein 1046349 4066352 MGAS2096_Spy1085 Streptococcus pyogenes MGAS2096 outer surface protein YP_600681.1 1045291 R 370565 CDS YP_600682.1 94992583 4066353 complement(1046395..1047819) 1 NC_008023.1 Beta-glucosidase 1047819 bglA2 4066353 bglA2 Streptococcus pyogenes MGAS2096 Beta-glucosidase YP_600682.1 1046395 R 370565 CDS YP_600683.1 94992584 4066354 1048008..1048715 1 NC_008023.1 nicotinamide mononucleotide transporter 1048715 4066354 MGAS2096_Spy1087 Streptococcus pyogenes MGAS2096 nicotinamide mononucleotide transporter YP_600683.1 1048008 D 370565 CDS YP_600684.1 94992585 4066355 complement(1048720..1048878) 1 NC_008023.1 putative cytoplasmic protein 1048878 4066355 MGAS2096_Spy1088 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600684.1 1048720 R 370565 CDS YP_600685.2 162139129 4066356 complement(1048947..1050254) 1 NC_008023.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 1050254 obgE 4066356 obgE Streptococcus pyogenes MGAS2096 GTPase ObgE YP_600685.2 1048947 R 370565 CDS YP_600686.1 94992587 4066357 complement(1050317..1050445) 1 NC_008023.1 hypothetical protein 1050445 4066357 MGAS2096_Spy1090 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600686.1 1050317 R 370565 CDS YP_600687.1 94992588 4066358 1050669..1051202 1 NC_008023.1 transposase 1051202 4066358 MGAS2096_Spy1091 Streptococcus pyogenes MGAS2096 transposase YP_600687.1 1050669 D 370565 CDS YP_600688.1 94992589 4066359 1051223..1051786 1 NC_008023.1 transposase 1051786 4066359 MGAS2096_Spy1092 Streptococcus pyogenes MGAS2096 transposase YP_600688.1 1051223 D 370565 CDS YP_600689.1 94992590 4066360 1051801..1052028 1 NC_008023.1 transposase 1052028 4066360 MGAS2096_Spy1093 Streptococcus pyogenes MGAS2096 transposase YP_600689.1 1051801 D 370565 CDS YP_600690.1 94992591 4066361 complement(1052077..1052811) 1 NC_008023.1 ribosomal small subunit pseudouridine synthase A 1052811 rsuA 4066361 rsuA Streptococcus pyogenes MGAS2096 ribosomal small subunit pseudouridine synthase A YP_600690.1 1052077 R 370565 CDS YP_600691.1 94992592 4066362 1052922..1053287 1 NC_008023.1 hypothetical protein 1053287 4066362 MGAS2096_Spy1095 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600691.1 1052922 D 370565 CDS YP_600692.1 94992593 4066363 complement(1053407..1054096) 1 NC_008023.1 major facilitator transporter 1054096 4066363 MGAS2096_Spy1096 Streptococcus pyogenes MGAS2096 major facilitator transporter YP_600692.1 1053407 R 370565 CDS YP_600693.1 94992594 4066364 complement(1054144..1054494) 1 NC_008023.1 major facilitator transporter 1054494 4066364 MGAS2096_Spy1097 Streptococcus pyogenes MGAS2096 major facilitator transporter YP_600693.1 1054144 R 370565 CDS YP_600694.1 94992595 4065225 complement(1054412..1054627) 1 NC_008023.1 major facilitator transporter 1054627 4065225 MGAS2096_Spy1098 Streptococcus pyogenes MGAS2096 major facilitator transporter YP_600694.1 1054412 R 370565 CDS YP_600695.1 94992596 4065226 1054929..1056485 1 NC_008023.1 hypothetical protein 1056485 4065226 MGAS2096_Spy1099 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600695.1 1054929 D 370565 CDS YP_600696.1 94992597 4065227 complement(1056590..1056991) 1 NC_008023.1 thioesterase superfamily protein 1056991 4065227 MGAS2096_Spy1100 Streptococcus pyogenes MGAS2096 thioesterase superfamily protein YP_600696.1 1056590 R 370565 CDS YP_600697.1 94992598 4065228 complement(1057076..1057315) 1 NC_008023.1 phosphorylase Pnp/Udp family protein 1057315 4065228 MGAS2096_Spy1101 Streptococcus pyogenes MGAS2096 phosphorylase Pnp/Udp family protein YP_600697.1 1057076 R 370565 CDS YP_600698.1 94992599 4065229 complement(1057387..1057587) 1 NC_008023.1 phosphorylase Pnp/Udp family protein 1057587 4065229 MGAS2096_Spy1102 Streptococcus pyogenes MGAS2096 phosphorylase Pnp/Udp family protein YP_600698.1 1057387 R 370565 CDS YP_600699.1 94992600 4065230 complement(1057904..1059685) 1 NC_008023.1 site-specific recombinase 1059685 4065230 MGAS2096_Spy1103 Streptococcus pyogenes MGAS2096 site-specific recombinase YP_600699.1 1057904 R 370565 CDS YP_600700.1 94992601 4065231 complement(1059868..1060245) 1 NC_008023.1 MazF protein 1060245 4065231 MGAS2096_Spy1104 Streptococcus pyogenes MGAS2096 MazF protein YP_600700.1 1059868 R 370565 CDS YP_600701.1 94992602 4065232 complement(1060848..1061333) 1 NC_008023.1 RNA polymerase ECF-type sigma factor 1061333 4065232 MGAS2096_Spy1105 Streptococcus pyogenes MGAS2096 RNA polymerase ECF-type sigma factor YP_600701.1 1060848 R 370565 CDS YP_600702.1 94992603 4065233 complement(1061809..1061979) 1 NC_008023.1 hypothetical protein 1061979 4065233 MGAS2096_Spy1106 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600702.1 1061809 R 370565 CDS YP_600703.1 94992604 4065234 complement(1062074..1063105) 1 NC_008023.1 two-component system histidine kinase 1063105 4065234 MGAS2096_Spy1107 Streptococcus pyogenes MGAS2096 two-component system histidine kinase YP_600703.1 1062074 R 370565 CDS YP_600704.1 94992605 4065235 complement(1063102..1063344) 1 NC_008023.1 two-component response regulator 1063344 4065235 MGAS2096_Spy1108 Streptococcus pyogenes MGAS2096 two-component response regulator YP_600704.1 1063102 R 370565 CDS YP_600705.1 94992606 4065236 complement(1063344..1063823) 1 NC_008023.1 two-component response regulator 1063823 4065236 MGAS2096_Spy1109 Streptococcus pyogenes MGAS2096 two-component response regulator YP_600705.1 1063344 R 370565 CDS YP_600706.1 94992607 4065237 complement(1063849..1066446) 1 NC_008023.1 ABC transporter permease 1066446 4065237 MGAS2096_Spy1110 Streptococcus pyogenes MGAS2096 ABC transporter permease YP_600706.1 1063849 R 370565 CDS YP_600707.1 94992608 4065238 complement(1066400..1067086) 1 NC_008023.1 ABC transporter ATP-binding protein 1067086 4065238 MGAS2096_Spy1111 Streptococcus pyogenes MGAS2096 ABC transporter ATP-binding protein YP_600707.1 1066400 R 370565 CDS YP_600708.1 94992609 4065239 complement(1067207..1067737) 1 NC_008023.1 transcriptional regulator 1067737 4065239 MGAS2096_Spy1112 Streptococcus pyogenes MGAS2096 transcriptional regulator YP_600708.1 1067207 R 370565 CDS YP_600709.1 94992610 4065240 1067839..1069257 1 NC_008023.1 Na+ driven multidrug efflux pump 1069257 4065240 MGAS2096_Spy1113 Streptococcus pyogenes MGAS2096 Na+ driven multidrug efflux pump YP_600709.1 1067839 D 370565 CDS YP_600710.1 94992611 4065241 complement(1069312..1069497) 1 NC_008023.1 hypothetical protein 1069497 4065241 MGAS2096_Spy1114 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600710.1 1069312 R 370565 CDS YP_600711.1 94992612 4065242 complement(1069501..1070259) 1 NC_008023.1 ferredoxin 1070259 4065242 MGAS2096_Spy1115 Streptococcus pyogenes MGAS2096 ferredoxin YP_600711.1 1069501 R 370565 CDS YP_600712.1 94992613 4065243 complement(1070268..1070864) 1 NC_008023.1 TetR family transcriptional regulator 1070864 4065243 MGAS2096_Spy1116 Streptococcus pyogenes MGAS2096 TetR family transcriptional regulator YP_600712.1 1070268 R 370565 CDS YP_600713.1 94992614 4065244 complement(1070986..1071693) 1 NC_008023.1 hypothetical protein 1071693 4065244 MGAS2096_Spy1117 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600713.1 1070986 R 370565 CDS YP_600714.1 94992615 4065001 complement(1071696..1072328) 1 NC_008023.1 virginiamycin A acetyltransferase 1072328 4065001 MGAS2096_Spy1118 Streptococcus pyogenes MGAS2096 virginiamycin A acetyltransferase YP_600714.1 1071696 R 370565 CDS YP_600715.1 94992616 4065002 complement(1072455..1072748) 1 NC_008023.1 hypothetical protein 1072748 4065002 MGAS2096_Spy1119 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600715.1 1072455 R 370565 CDS YP_600716.1 94992617 4065003 1073071..1073430 1 NC_008023.1 MerR family transcriptional regulator 1073430 4065003 MGAS2096_Spy1120 Streptococcus pyogenes MGAS2096 MerR family transcriptional regulator YP_600716.1 1073071 D 370565 CDS YP_600717.1 94992618 4065004 complement(1073455..1075233) 1 NC_008023.1 antigen-like protein 1075233 4065004 MGAS2096_Spy1121 Streptococcus pyogenes MGAS2096 antigen-like protein YP_600717.1 1073455 R 370565 CDS YP_600718.1 94992619 4065005 complement(1075269..1076054) 1 NC_008023.1 sortase 1076054 4065005 MGAS2096_Spy1122 Streptococcus pyogenes MGAS2096 sortase YP_600718.1 1075269 R 370565 CDS YP_600719.1 94992620 4065006 complement(1076122..1076526) 1 NC_008023.1 hypothetical protein 1076526 4065006 MGAS2096_Spy1123 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600719.1 1076122 R 370565 CDS YP_600720.1 94992621 4065007 complement(1076507..1077358) 1 NC_008023.1 adenine-specific methyltransferase 1077358 4065007 MGAS2096_Spy1124 Streptococcus pyogenes MGAS2096 adenine-specific methyltransferase YP_600720.1 1076507 R 370565 CDS YP_600721.1 94992622 4065008 complement(1077345..1079774) 1 NC_008023.1 TRSE protein 1079774 4065008 MGAS2096_Spy1125 Streptococcus pyogenes MGAS2096 TRSE protein YP_600721.1 1077345 R 370565 CDS YP_600722.1 94992623 4065009 complement(1080101..1080364) 1 NC_008023.1 hypothetical protein 1080364 4065009 MGAS2096_Spy1126 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600722.1 1080101 R 370565 CDS YP_600723.1 94992624 4065010 complement(1080367..1081218) 1 NC_008023.1 hypothetical protein 1081218 4065010 MGAS2096_Spy1127 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600723.1 1080367 R 370565 CDS YP_600724.1 94992625 4065011 complement(1081209..1081835) 1 NC_008023.1 adenine-specific methyltransferase 1081835 4065011 MGAS2096_Spy1128 Streptococcus pyogenes MGAS2096 adenine-specific methyltransferase YP_600724.1 1081209 R 370565 CDS YP_600725.1 94992626 4065012 complement(1081864..1082235) 1 NC_008023.1 aspartyl/glutamyl-tRNA amidotransferase subunit A 1082235 4065012 MGAS2096_Spy1129 Streptococcus pyogenes MGAS2096 aspartyl/glutamyl-tRNA amidotransferase subunit A YP_600725.1 1081864 R 370565 CDS YP_600726.1 94992627 4065013 complement(1082250..1084043) 1 NC_008023.1 TraG/TraD family protein 1084043 4065013 MGAS2096_Spy1130 Streptococcus pyogenes MGAS2096 TraG/TraD family protein YP_600726.1 1082250 R 370565 CDS YP_600727.1 94992628 4065014 complement(1084243..1085103) 1 NC_008023.1 hypothetical protein 1085103 4065014 MGAS2096_Spy1131 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600727.1 1084243 R 370565 CDS YP_600728.1 94992629 4065015 complement(1085103..1085921) 1 NC_008023.1 hypothetical protein 1085921 4065015 MGAS2096_Spy1132 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600728.1 1085103 R 370565 CDS YP_600729.1 94992630 4065016 complement(1085863..1087338) 1 NC_008023.1 relaxase 1087338 4065016 MGAS2096_Spy1133 Streptococcus pyogenes MGAS2096 relaxase YP_600729.1 1085863 R 370565 CDS YP_600730.1 94992631 4065017 complement(1087275..1087607) 1 NC_008023.1 relaxosome component 1087607 4065017 MGAS2096_Spy1134 Streptococcus pyogenes MGAS2096 relaxosome component YP_600730.1 1087275 R 370565 CDS YP_600731.1 94992632 4065018 complement(1088210..1089199) 1 NC_008023.1 LtrC 1089199 4065018 MGAS2096_Spy1135 Streptococcus pyogenes MGAS2096 LtrC YP_600731.1 1088210 R 370565 CDS YP_600732.1 94992633 4065019 complement(1089279..1090217) 1 NC_008023.1 hypothetical protein 1090217 4065019 MGAS2096_Spy1136 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600732.1 1089279 R 370565 CDS YP_600733.1 94992634 4066326 complement(1090355..1091569) 1 NC_008023.1 hypothetical protein 1091569 4066326 MGAS2096_Spy1137 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600733.1 1090355 R 370565 CDS YP_600734.1 94992635 4066327 complement(1091687..1092016) 1 NC_008023.1 hypothetical protein 1092016 4066327 MGAS2096_Spy1138 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600734.1 1091687 R 370565 CDS YP_600735.1 94992636 4066328 complement(1092092..1093030) 1 NC_008023.1 SNF2 family; superfamily II DNA/RNA helicase 1093030 4066328 MGAS2096_Spy1139 Streptococcus pyogenes MGAS2096 superfamily II DNA/RNA helicase YP_600735.1 1092092 R 370565 CDS YP_600736.1 94992637 4066329 complement(1092958..1094889) 1 NC_008023.1 site-specific recombinase 1094889 4066329 MGAS2096_Spy1140 Streptococcus pyogenes MGAS2096 site-specific recombinase YP_600736.1 1092958 R 370565 CDS YP_600737.1 94992638 4066330 complement(1095206..1095436) 1 NC_008023.1 putative cytoplasmic protein 1095436 4066330 MGAS2096_Spy1141 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600737.1 1095206 R 370565 CDS YP_600738.1 94992639 4066331 complement(1095513..1096367) 1 NC_008023.1 chromosome partitioning protein parB 1096367 4066331 MGAS2096_Spy1142 Streptococcus pyogenes MGAS2096 chromosome partitioning protein parB YP_600738.1 1095513 R 370565 CDS YP_600739.1 94992640 4066332 complement(1096375..1097340) 1 NC_008023.1 plasmid recombination protein Mob family 1097340 4066332 MGAS2096_Spy1143 Streptococcus pyogenes MGAS2096 plasmid recombination protein Mob family YP_600739.1 1096375 R 370565 CDS YP_600740.1 94992641 4066333 complement(1097818..1098813) 1 NC_008023.1 hypothetical protein 1098813 4066333 MGAS2096_Spy1144 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600740.1 1097818 R 370565 CDS YP_600741.1 94992642 4066334 complement(1098968..1099489) 1 NC_008023.1 RNA polymerase ECF-type sigma factor 1099489 4066334 MGAS2096_Spy1145 Streptococcus pyogenes MGAS2096 RNA polymerase ECF-type sigma factor YP_600741.1 1098968 R 370565 CDS YP_600742.1 94992643 4066335 complement(1099518..1099949) 1 NC_008023.1 putative cytoplasmic protein 1099949 4066335 MGAS2096_Spy1146 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600742.1 1099518 R 370565 CDS YP_600743.1 94992644 4066336 complement(1100044..1100619) 1 NC_008023.1 RNA polymerase sigma-B factor 1100619 4066336 MGAS2096_Spy1147 Streptococcus pyogenes MGAS2096 RNA polymerase sigma-B factor YP_600743.1 1100044 R 370565 CDS YP_600744.1 94992645 4066337 complement(1101044..1101217) 1 NC_008023.1 hypothetical protein 1101217 4066337 MGAS2096_Spy1148 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600744.1 1101044 R 370565 CDS YP_600745.1 94992646 4066338 complement(1101269..1103188) 1 NC_008023.1 tetracycline resistance protein tetM 1103188 4066338 MGAS2096_Spy1149 Streptococcus pyogenes MGAS2096 tetracycline resistance protein tetM YP_600745.1 1101269 R 370565 CDS YP_600746.1 94992647 4066339 complement(1103555..1103929) 1 NC_008023.1 TnpV 1103929 4066339 MGAS2096_Spy1150 Streptococcus pyogenes MGAS2096 TnpV YP_600746.1 1103555 R 370565 CDS YP_600747.1 94992648 4066340 complement(1103910..1111160) 1 NC_008023.1 SNF2 family; superfamily II DNA/RNA helicase 1111160 4066340 MGAS2096_Spy1151 Streptococcus pyogenes MGAS2096 superfamily II DNA/RNA helicase YP_600747.1 1103910 R 370565 CDS YP_600748.1 94992649 4066341 complement(1111195..1111419) 1 NC_008023.1 hypothetical protein 1111419 4066341 MGAS2096_Spy1152 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600748.1 1111195 R 370565 CDS YP_600749.1 94992650 4066342 complement(1111635..1112330) 1 NC_008023.1 hypothetical protein 1112330 4066342 MGAS2096_Spy1154 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600749.1 1111635 R 370565 CDS YP_600750.1 94992651 4066343 1112290..1113006 1 NC_008023.1 hypothetical protein 1113006 4066343 MGAS2096_Spy1153 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600750.1 1112290 D 370565 CDS YP_600751.1 94992652 4066344 complement(1113060..1113332) 1 NC_008023.1 hypothetical protein 1113332 4066344 MGAS2096_Spy1155 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600751.1 1113060 R 370565 CDS YP_600752.1 94992653 4066345 complement(1113797..1117945) 1 NC_008023.1 collagen adhesion protein 1117945 4066345 MGAS2096_Spy1156 Streptococcus pyogenes MGAS2096 collagen adhesion protein YP_600752.1 1113797 R 370565 CDS YP_600753.1 94992654 4065117 complement(1118131..1119096) 1 NC_008023.1 chromosome partitioning protein parB 1119096 4065117 MGAS2096_Spy1157 Streptococcus pyogenes MGAS2096 chromosome partitioning protein parB YP_600753.1 1118131 R 370565 CDS YP_600754.1 94992655 4065118 complement(1119020..1119847) 1 NC_008023.1 chromosome partitioning protein parA 1119847 4065118 MGAS2096_Spy1158 Streptococcus pyogenes MGAS2096 chromosome partitioning protein parA YP_600754.1 1119020 R 370565 CDS YP_600755.1 94992656 4065119 complement(1119967..1120305) 1 NC_008023.1 hypothetical protein 1120305 4065119 MGAS2096_Spy1159 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600755.1 1119967 R 370565 CDS YP_600756.1 94992657 4065120 complement(1120818..1122212) 1 NC_008023.1 23S rRNA m(5)U1939 methyltransferase 1122212 4065120 MGAS2096_Spy1160 Streptococcus pyogenes MGAS2096 23S rRNA m(5)U1939 methyltransferase YP_600756.1 1120818 R 370565 CDS YP_600757.1 94992658 4065121 complement(1122363..1123712) 1 NC_008023.1 LytR family transcriptional regulator 1123712 4065121 MGAS2096_Spy1161 Streptococcus pyogenes MGAS2096 LytR family transcriptional regulator YP_600757.1 1122363 R 370565 CDS YP_600758.1 94992659 4065122 complement(1123920..1124411) 1 NC_008023.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 1124411 aroK 4065122 aroK Streptococcus pyogenes MGAS2096 shikimate kinase YP_600758.1 1123920 R 370565 CDS YP_600759.1 94992660 4065123 complement(1124404..1125696) 1 NC_008023.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1125696 4065123 MGAS2096_Spy1163 Streptococcus pyogenes MGAS2096 3-phosphoshikimate 1-carboxyvinyltransferase YP_600759.1 1124404 R 370565 CDS YP_600760.1 94992661 4065124 complement(1125798..1126763) 1 NC_008023.1 ribonuclease BN 1126763 4065124 MGAS2096_Spy1164 Streptococcus pyogenes MGAS2096 ribonuclease BN YP_600760.1 1125798 R 370565 CDS YP_600761.1 94992662 4065125 complement(1126765..1127625) 1 NC_008023.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; methionine aminopeptidase 1127625 map 4065125 map Streptococcus pyogenes MGAS2096 methionine aminopeptidase YP_600761.1 1126765 R 370565 CDS YP_600762.1 94992663 4065126 complement(1127641..1128936) 1 NC_008023.1 hypothetical protein 1128936 4065126 MGAS2096_Spy1166 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600762.1 1127641 R 370565 CDS YP_600763.1 94992664 4065127 complement(1128933..1129475) 1 NC_008023.1 ribosomal-protein-S5-alanine acetyltransferase 1129475 4065127 MGAS2096_Spy1167 Streptococcus pyogenes MGAS2096 ribosomal-protein-S5-alanine acetyltransferase YP_600763.1 1128933 R 370565 CDS YP_600764.1 94992665 4065128 complement(1129713..1130282) 1 NC_008023.1 protein G-related alpha 2M-binding protein 1130282 grab 4065128 grab Streptococcus pyogenes MGAS2096 protein G-related alpha 2M-binding protein YP_600764.1 1129713 R 370565 CDS YP_600765.1 94992666 4065129 complement(1130640..1131899) 1 NC_008023.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1131899 murZ 4065129 murZ Streptococcus pyogenes MGAS2096 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_600765.1 1130640 R 370565 CDS YP_600766.1 94992667 4065130 complement(1132073..1133269) 1 NC_008023.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 1133269 metK2 4065130 metK2 Streptococcus pyogenes MGAS2096 S-adenosylmethionine synthetase YP_600766.1 1132073 R 370565 CDS YP_600767.1 94992668 4065131 complement(1133805..1136183) 1 NC_008023.1 internalin protein 1136183 inlA 4065131 inlA Streptococcus pyogenes MGAS2096 internalin protein YP_600767.1 1133805 R 370565 CDS YP_600768.1 94992669 4065132 1136387..1137205 1 NC_008023.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 1137205 birA 4065132 birA Streptococcus pyogenes MGAS2096 biotin--protein ligase YP_600768.1 1136387 D 370565 CDS YP_600769.1 94992670 4065133 complement(1137304..1137564) 1 NC_008023.1 hypothetical protein 1137564 4065133 MGAS2096_Spy1173 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600769.1 1137304 R 370565 CDS YP_600770.1 94992671 4065134 complement(1137649..1138791) 1 NC_008023.1 transposase 1138791 4065134 MGAS2096_Spy1174 Streptococcus pyogenes MGAS2096 transposase YP_600770.1 1137649 R 370565 CDS YP_600771.1 94992672 4065135 complement(1139052..1140314) 1 NC_008023.1 DNA polymerase III subunit gamma/tau 1140314 4065135 MGAS2096_Spy1175 Streptococcus pyogenes MGAS2096 DNA polymerase III subunit gamma/tau YP_600771.1 1139052 R 370565 CDS YP_600772.1 94992673 4065439 complement(1140736..1141233) 1 NC_008023.1 GAF domain-containing protein 1141233 4065439 MGAS2096_Spy1176 Streptococcus pyogenes MGAS2096 GAF domain-containing protein YP_600772.1 1140736 R 370565 CDS YP_600773.1 94992674 4065440 1141378..1142187 1 NC_008023.1 hypothetical protein 1142187 4065440 MGAS2096_Spy1177 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600773.1 1141378 D 370565 CDS YP_600774.1 94992675 4065441 complement(1142240..1142503) 1 NC_008023.1 hypothetical protein 1142503 4065441 MGAS2096_Spy1178 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600774.1 1142240 R 370565 CDS YP_600775.1 94992676 4065442 complement(1142583..1142771) 1 NC_008023.1 uridine kinase 1142771 4065442 MGAS2096_Spy1179 Streptococcus pyogenes MGAS2096 uridine kinase YP_600775.1 1142583 R 370565 CDS YP_600776.1 94992677 4065443 complement(1142806..1143222) 1 NC_008023.1 uridine kinase 1143222 udk 4065443 udk Streptococcus pyogenes MGAS2096 uridine kinase YP_600776.1 1142806 R 370565 CDS YP_600777.1 94992678 4065444 1143275..1144393 1 NC_008023.1 ATP-dependent RNA helicase 1144393 deaD2 4065444 deaD2 Streptococcus pyogenes MGAS2096 ATP-dependent RNA helicase YP_600777.1 1143275 D 370565 CDS YP_600778.1 94992679 4065445 complement(1144504..1144992) 1 NC_008023.1 polysaccharide deacetylase family protein 1144992 4065445 MGAS2096_Spy1182 Streptococcus pyogenes MGAS2096 polysaccharide deacetylase family protein YP_600778.1 1144504 R 370565 CDS YP_600779.1 94992680 4065446 complement(1145043..1145777) 1 NC_008023.1 polysaccharide deacetylase family protein 1145777 4065446 MGAS2096_Spy1183 Streptococcus pyogenes MGAS2096 polysaccharide deacetylase family protein YP_600779.1 1145043 R 370565 CDS YP_600780.1 94992681 4065447 complement(1145873..1147300) 1 NC_008023.1 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1147300 gapN 4065447 gapN Streptococcus pyogenes MGAS2096 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase YP_600780.1 1145873 R 370565 CDS YP_600781.1 94992682 4065448 complement(1147485..1149218) 1 NC_008023.1 phosphoenolpyruvate-protein phosphotransferase 1149218 pstI 4065448 pstI Streptococcus pyogenes MGAS2096 phosphoenolpyruvate-protein phosphotransferase YP_600781.1 1147485 R 370565 CDS YP_600782.1 94992683 4065449 complement(1149223..1149486) 1 NC_008023.1 phosphocarrier protein HPr 1149486 ptsH 4065449 ptsH Streptococcus pyogenes MGAS2096 phosphocarrier protein HPr YP_600782.1 1149223 R 370565 CDS YP_600783.1 94992684 4065450 1149846..1150097 1 NC_008023.1 glutaredoxin 1150097 nrdH 4065450 nrdH Streptococcus pyogenes MGAS2096 glutaredoxin YP_600783.1 1149846 D 370565 CDS YP_600784.1 94992685 4065451 1150117..1152276 1 NC_008023.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1152276 nrdE2 4065451 nrdE2 Streptococcus pyogenes MGAS2096 ribonucleotide-diphosphate reductase subunit alpha YP_600784.1 1150117 D 370565 CDS YP_600785.1 94992686 4065452 1152598..1153557 1 NC_008023.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 1153557 nrdF 4065452 nrdF Streptococcus pyogenes MGAS2096 ribonucleotide-diphosphate reductase subunit beta YP_600785.1 1152598 D 370565 CDS YP_600786.1 94992687 4065453 1153532..1154845 1 NC_008023.1 chloride channel protein 1154845 4065453 MGAS2096_Spy1190 Streptococcus pyogenes MGAS2096 chloride channel protein YP_600786.1 1153532 D 370565 CDS YP_600787.1 94992688 4065454 1154941..1155234 1 NC_008023.1 transposase 1155234 4065454 MGAS2096_Spy1191 Streptococcus pyogenes MGAS2096 transposase YP_600787.1 1154941 D 370565 CDS YP_600788.1 94992689 4065455 1155267..1155836 1 NC_008023.1 transposase 1155836 4065455 MGAS2096_Spy1192 Streptococcus pyogenes MGAS2096 transposase YP_600788.1 1155267 D 370565 CDS YP_600789.1 94992690 4065456 1155876..1156097 1 NC_008023.1 transposase 1156097 4065456 MGAS2096_Spy1193 Streptococcus pyogenes MGAS2096 transposase YP_600789.1 1155876 D 370565 CDS YP_600790.1 94992691 4065457 complement(1156191..1156886) 1 NC_008023.1 CAAX amino protease 1156886 4065457 MGAS2096_Spy1194 Streptococcus pyogenes MGAS2096 CAAX amino protease YP_600790.1 1156191 R 370565 CDS YP_600791.1 94992692 4065458 complement(1156905..1157666) 1 NC_008023.1 hypothetical protein 1157666 4065458 MGAS2096_Spy1195 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600791.1 1156905 R 370565 CDS YP_600792.1 94992693 4065538 complement(1157663..1157893) 1 NC_008023.1 Cro/CI family transcriptional regulator 1157893 4065538 MGAS2096_Spy1196 Streptococcus pyogenes MGAS2096 Cro/CI family transcriptional regulator YP_600792.1 1157663 R 370565 CDS YP_600793.1 94992694 4065539 complement(1157919..1158059) 1 NC_008023.1 hypothetical protein 1158059 4065539 MGAS2096_Spy1197 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600793.1 1157919 R 370565 CDS YP_600794.1 94992695 4065540 complement(1158238..1160856) 1 NC_008023.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1160856 alaS 4065540 alaS Streptococcus pyogenes MGAS2096 alanyl-tRNA synthetase YP_600794.1 1158238 R 370565 CDS YP_600795.1 94992696 4065541 complement(1161243..1162298) 1 NC_008023.1 cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein; foldase PrsA 1162298 prsA 4065541 prsA Streptococcus pyogenes MGAS2096 foldase PrsA YP_600795.1 1161243 R 370565 CDS YP_600796.1 94992697 4065542 complement(1162361..1163068) 1 NC_008023.1 O-methyltransferase 1163068 4065542 MGAS2096_Spy1200 Streptococcus pyogenes MGAS2096 O-methyltransferase YP_600796.1 1162361 R 370565 CDS YP_600797.1 94992698 4065543 complement(1163134..1164330) 1 NC_008023.1 major facilitator superfamily permease 1164330 4065543 MGAS2096_Spy1201 Streptococcus pyogenes MGAS2096 major facilitator superfamily permease YP_600797.1 1163134 R 370565 CDS YP_600798.1 94992699 4065544 complement(1164706..1166511) 1 NC_008023.1 oligoendopeptidase F 1166511 pepB 4065544 pepB Streptococcus pyogenes MGAS2096 oligoendopeptidase F YP_600798.1 1164706 R 370565 CDS YP_600799.1 94992700 4065545 complement(1166524..1167486) 1 NC_008023.1 putative competence protein/transcription factor 1167486 4065545 MGAS2096_Spy1203 Streptococcus pyogenes MGAS2096 putative competence protein/transcription factor YP_600799.1 1166524 R 370565 CDS YP_600800.1 94992701 4065546 complement(1167781..1168497) 1 NC_008023.1 ribosomal small subunit pseudouridine synthase A 1168497 4065546 MGAS2096_Spy1204 Streptococcus pyogenes MGAS2096 ribosomal small subunit pseudouridine synthase A YP_600800.1 1167781 R 370565 CDS YP_600801.1 94992702 4065547 complement(1168616..1169443) 1 NC_008023.1 glucosamine-6-phosphate isomerase 1169443 nagB 4065547 nagB Streptococcus pyogenes MGAS2096 glucosamine-6-phosphate isomerase YP_600801.1 1168616 R 370565 CDS YP_600802.1 94992703 4065548 1169522..1170550 1 NC_008023.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 1170550 queA 4065548 queA Streptococcus pyogenes MGAS2096 S-adenosylmethionine--tRNA ribosyltransferase-isomerase YP_600802.1 1169522 D 370565 CDS YP_600803.1 94992704 4065549 1170557..1171777 1 NC_008023.1 putative cytoplasmic protein 1171777 4065549 MGAS2096_Spy1207 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600803.1 1170557 D 370565 CDS YP_600804.1 94992705 4065550 complement(1171891..1172481) 1 NC_008023.1 hypothetical protein 1172481 4065550 MGAS2096_Spy1208 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600804.1 1171891 R 370565 CDS YP_600805.1 94992706 4065551 complement(1172478..1172726) 1 NC_008023.1 hypothetical protein 1172726 4065551 MGAS2096_Spy1209 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600805.1 1172478 R 370565 CDS YP_600806.1 94992707 4065552 complement(1172782..1172937) 1 NC_008023.1 hypothetical protein 1172937 4065552 MGAS2096_Spy1210 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600806.1 1172782 R 370565 CDS YP_600807.1 94992708 4065553 complement(1173104..1173709) 1 NC_008023.1 superoxide dismutase 1173709 sodA 4065553 sodA Streptococcus pyogenes MGAS2096 superoxide dismutase YP_600807.1 1173104 R 370565 CDS YP_600808.1 94992709 4065554 complement(1173806..1174846) 1 NC_008023.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 1174846 holA 4065554 holA Streptococcus pyogenes MGAS2096 DNA polymerase III subunit delta YP_600808.1 1173806 R 370565 CDS YP_600809.1 94992710 4065555 complement(1174917..1175078) 1 NC_008023.1 COME operon protein 3 1175078 4065555 MGAS2096_Spy1213 Streptococcus pyogenes MGAS2096 COME operon protein 3 YP_600809.1 1174917 R 370565 CDS YP_600810.1 94992711 4065556 complement(1175208..1177160) 1 NC_008023.1 COME operon protein 3 1177160 comEC 4065556 comEC Streptococcus pyogenes MGAS2096 COME operon protein 3 YP_600810.1 1175208 R 370565 CDS YP_600811.1 94992712 4065595 complement(1177361..1177804) 1 NC_008023.1 COME operon protein 1 1177804 4065595 MGAS2096_Spy1215 Streptococcus pyogenes MGAS2096 COME operon protein 1 YP_600811.1 1177361 R 370565 CDS YP_600812.1 94992713 4065596 complement(1178004..1178822) 1 NC_008023.1 1-acyl-sn-glycerol-3-phosphate acyltransferase 1178822 4065596 MGAS2096_Spy1217 Streptococcus pyogenes MGAS2096 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_600812.1 1178004 R 370565 CDS YP_600813.1 94992714 4065597 1178784..1179638 1 NC_008023.1 methyltransferase 1179638 4065597 MGAS2096_Spy1216 Streptococcus pyogenes MGAS2096 methyltransferase YP_600813.1 1178784 D 370565 CDS YP_600814.1 94992715 4065598 1179628..1179906 1 NC_008023.1 hypothetical protein 1179906 4065598 MGAS2096_Spy1218 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600814.1 1179628 D 370565 CDS YP_600815.1 94992716 4065599 complement(1179930..1180904) 1 NC_008023.1 Kup system potassium uptake protein 1180904 4065599 MGAS2096_Spy1219 Streptococcus pyogenes MGAS2096 Kup system potassium uptake protein YP_600815.1 1179930 R 370565 CDS YP_600816.1 94992717 4065600 complement(1180865..1181311) 1 NC_008023.1 Kup system potassium uptake protein 1181311 4065600 MGAS2096_Spy1220 Streptococcus pyogenes MGAS2096 Kup system potassium uptake protein YP_600816.1 1180865 R 370565 CDS YP_600817.1 94992718 4065601 complement(1181289..1181930) 1 NC_008023.1 Kup system potassium uptake protein 1181930 4065601 MGAS2096_Spy1221 Streptococcus pyogenes MGAS2096 Kup system potassium uptake protein YP_600817.1 1181289 R 370565 CDS YP_600818.1 94992719 4065602 complement(1182057..1182368) 1 NC_008023.1 ATP-dependent RNA helicase 1182368 4065602 MGAS2096_Spy1222 Streptococcus pyogenes MGAS2096 ATP-dependent RNA helicase YP_600818.1 1182057 R 370565 CDS YP_600819.1 94992720 4065603 complement(1182286..1182456) 1 NC_008023.1 ATP-dependent RNA helicase 1182456 4065603 MGAS2096_Spy1223 Streptococcus pyogenes MGAS2096 ATP-dependent RNA helicase YP_600819.1 1182286 R 370565 CDS YP_600820.1 94992721 4065604 complement(1182426..1183676) 1 NC_008023.1 ATP-dependent RNA helicase 1183676 deaD 4065604 deaD Streptococcus pyogenes MGAS2096 ATP-dependent RNA helicase YP_600820.1 1182426 R 370565 CDS YP_600821.1 94992722 4065605 complement(1183983..1185527) 1 NC_008023.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 1185527 prfC 4065605 prfC Streptococcus pyogenes MGAS2096 peptide chain release factor 3 YP_600821.1 1183983 R 370565 CDS YP_600822.1 94992723 4065606 1185481..1185705 1 NC_008023.1 hypothetical protein 1185705 4065606 MGAS2096_Spy1225 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600822.1 1185481 D 370565 CDS YP_600823.1 94992724 4065607 complement(1185775..1186470) 1 NC_008023.1 hypothetical protein 1186470 4065607 MGAS2096_Spy1227 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600823.1 1185775 R 370565 CDS YP_600824.1 94992725 4065608 complement(1186551..1187942) 1 NC_008023.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 1187942 murF 4065608 murF Streptococcus pyogenes MGAS2096 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase YP_600824.1 1186551 R 370565 CDS YP_600825.1 94992726 4065609 complement(1188141..1189187) 1 NC_008023.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 1189187 ddl 4065609 ddl Streptococcus pyogenes MGAS2096 D-alanyl-alanine synthetase A YP_600825.1 1188141 R 370565 CDS YP_600826.1 94992727 4065610 complement(1189288..1189884) 1 NC_008023.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 1189884 recR 4065610 recR Streptococcus pyogenes MGAS2096 recombination protein RecR YP_600826.1 1189288 R 370565 CDS YP_600827.1 94992728 4065611 complement(1189931..1190113) 1 NC_008023.1 penicillin-binding protein 1190113 4065611 MGAS2096_Spy1231 Streptococcus pyogenes MGAS2096 penicillin-binding protein YP_600827.1 1189931 R 370565 CDS YP_600828.1 94992729 4065612 complement(1190672..1191196) 1 NC_008023.1 formate transporter 1191196 4065612 MGAS2096_Spy1232 Streptococcus pyogenes MGAS2096 formate transporter YP_600828.1 1190672 R 370565 CDS YP_600829.1 94992730 4065613 complement(1191193..1191552) 1 NC_008023.1 formate transporter 1191552 4065613 MGAS2096_Spy1233 Streptococcus pyogenes MGAS2096 formate transporter YP_600829.1 1191193 R 370565 CDS YP_600830.1 94992731 4065614 complement(1191574..1192116) 1 NC_008023.1 hypothetical protein 1192116 4065614 MGAS2096_Spy1234 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600830.1 1191574 R 370565 CDS YP_600831.1 94992732 4065693 complement(1192277..1192798) 1 NC_008023.1 biotin repressor family transcriptional regulator 1192798 4065693 MGAS2096_Spy1235 Streptococcus pyogenes MGAS2096 biotin repressor family transcriptional regulator YP_600831.1 1192277 R 370565 CDS YP_600832.1 94992733 4065694 complement(1192906..1193601) 1 NC_008023.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 1193601 gpmA 4065694 gpmA Streptococcus pyogenes MGAS2096 phosphoglyceromutase YP_600832.1 1192906 R 370565 CDS YP_600833.1 94992734 4065695 1193828..1194775 1 NC_008023.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; subclass 1A is a dimer formed by two identical PyrD subunits each containing an FMN group; dihydroorotate dehydrogenase 1A 1194775 pyrD 4065695 pyrD Streptococcus pyogenes MGAS2096 dihydroorotate dehydrogenase 1A YP_600833.1 1193828 D 370565 CDS YP_600834.1 94992735 4065696 complement(1194830..1195003) 1 NC_008023.1 hypothetical protein 1195003 4065696 MGAS2096_Spy1238 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600834.1 1194830 R 370565 CDS YP_600835.1 94992736 4065697 complement(1195075..1195695) 1 NC_008023.1 lead, cadmium, zinc and mercury transporting ATPase 1195695 4065697 MGAS2096_Spy1239 Streptococcus pyogenes MGAS2096 lead, cadmium, zinc and mercury transporting ATPase YP_600835.1 1195075 R 370565 CDS YP_600836.1 94992737 4065698 complement(1195634..1196923) 1 NC_008023.1 lead, cadmium, zinc and mercury transporting ATPase 1196923 4065698 MGAS2096_Spy1240 Streptococcus pyogenes MGAS2096 lead, cadmium, zinc and mercury transporting ATPase YP_600836.1 1195634 R 370565 CDS YP_600837.1 94992738 4065699 complement(1197282..1197557) 1 NC_008023.1 DNA-binding protein HU 1197557 4065699 MGAS2096_Spy1241 Streptococcus pyogenes MGAS2096 DNA-binding protein HU YP_600837.1 1197282 R 370565 CDS YP_600838.1 94992739 4065700 complement(1197656..1198243) 1 NC_008023.1 hypothetical protein 1198243 4065700 MGAS2096_Spy1242 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600838.1 1197656 R 370565 CDS YP_600839.1 94992740 4065701 complement(1198221..1199081) 1 NC_008023.1 lipase/acylhydrolase 1199081 4065701 MGAS2096_Spy1243 Streptococcus pyogenes MGAS2096 lipase/acylhydrolase YP_600839.1 1198221 R 370565 CDS YP_600840.1 94992741 4065702 complement(1199056..1199907) 1 NC_008023.1 DegV family fatty acid-binding protein 1199907 4065702 MGAS2096_Spy1244 Streptococcus pyogenes MGAS2096 DegV family fatty acid-binding protein YP_600840.1 1199056 R 370565 CDS YP_600841.1 94992742 4065703 complement(1200173..1201051) 1 NC_008023.1 hypothetical protein 1201051 4065703 MGAS2096_Spy1245 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600841.1 1200173 R 370565 CDS YP_600842.1 94992743 4065704 complement(1201222..1202925) 1 NC_008023.1 DNA repair protein recN 1202925 recN 4065704 recN Streptococcus pyogenes MGAS2096 DNA repair protein recN YP_600842.1 1201222 R 370565 CDS YP_600843.1 94992744 4065705 complement(1202904..1203407) 1 NC_008023.1 arginine repressor ArgR 1203407 argR1 4065705 argR1 Streptococcus pyogenes MGAS2096 arginine repressor ArgR YP_600843.1 1202904 R 370565 CDS YP_600844.1 94992745 4065706 complement(1203361..1204188) 1 NC_008023.1 lantibotic precursor 1204188 4065706 MGAS2096_Spy1248 Streptococcus pyogenes MGAS2096 lantibotic precursor YP_600844.1 1203361 R 370565 CDS YP_600845.1 94992746 4065707 complement(1204181..1205053) 1 NC_008023.1 bifunctional; dimethylallyltransferase / geranyltranstransferase 1205053 fps 4065707 fps Streptococcus pyogenes MGAS2096 dimethylallyltransferase / geranyltranstransferase YP_600845.1 1204181 R 370565 CDS YP_600846.1 94992747 4065708 complement(1205053..1205268) 1 NC_008023.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 1205268 xseB 4065708 xseB Streptococcus pyogenes MGAS2096 exodeoxyribonuclease VII small subunit YP_600846.1 1205053 R 370565 CDS YP_600847.1 94992748 4065709 complement(1205246..1206601) 1 NC_008023.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 1206601 xseA 4065709 xseA Streptococcus pyogenes MGAS2096 exodeoxyribonuclease VII large subunit YP_600847.1 1205246 R 370565 CDS YP_600848.1 94992749 4065710 complement(1206739..1207599) 1 NC_008023.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 1207599 folD 4065710 folD Streptococcus pyogenes MGAS2096 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_600848.1 1206739 R 370565 CDS YP_600849.1 94992750 4065711 complement(1207801..1209504) 1 NC_008023.1 bifunctional; phosphoglucomutase/phosphomannomutase 1209504 4065711 MGAS2096_Spy1253 Streptococcus pyogenes MGAS2096 phosphoglucomutase/phosphomannomutase YP_600849.1 1207801 R 370565 CDS YP_600850.1 94992751 4065751 complement(1209673..1211115) 1 NC_008023.1 deoxyribodipyrimidine photolyase 1211115 phr 4065751 phr Streptococcus pyogenes MGAS2096 deoxyribodipyrimidine photolyase YP_600850.1 1209673 R 370565 CDS YP_600851.1 94992752 4065752 complement(1211231..1211968) 1 NC_008023.1 amino acid ABC transporter ATP-binding protein 1211968 artP 4065752 artP Streptococcus pyogenes MGAS2096 amino acid ABC transporter ATP-binding protein YP_600851.1 1211231 R 370565 CDS YP_600852.1 94992753 4065753 complement(1211965..1212651) 1 NC_008023.1 arginine ABC transporter permease 1212651 artQ 4065753 artQ Streptococcus pyogenes MGAS2096 arginine ABC transporter permease YP_600852.1 1211965 R 370565 CDS YP_600853.1 94992754 4065754 complement(1212778..1213008) 1 NC_008023.1 putative cytoplasmic protein 1213008 4065754 MGAS2096_Spy1257 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600853.1 1212778 R 370565 CDS YP_600854.1 94992755 4065755 1213306..1215588 1 NC_008023.1 ATP-dependent endopeptidase Clp ATP-binding subunit clpE 1215588 clpE 4065755 clpE Streptococcus pyogenes MGAS2096 ATP-dependent endopeptidase Clp ATP-binding subunit clpE YP_600854.1 1213306 D 370565 CDS YP_600855.1 94992756 4065756 1215716..1216171 1 NC_008023.1 Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) 1216171 mutT 4065756 mutT Streptococcus pyogenes MGAS2096 Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) YP_600855.1 1215716 D 370565 CDS YP_600856.1 94992757 4065757 1216222..1216524 1 NC_008023.1 putative cytoplasmic protein 1216524 4065757 MGAS2096_Spy1260 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600856.1 1216222 D 370565 CDS YP_600857.1 94992758 4065758 complement(1216788..1219589) 1 NC_008023.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 1219589 ileS 4065758 ileS Streptococcus pyogenes MGAS2096 isoleucyl-tRNA synthetase YP_600857.1 1216788 R 370565 CDS YP_600858.1 94992759 4065759 complement(1219862..1220620) 1 NC_008023.1 cell division initiation protein DivIVA 1220620 divIVAS 4065759 divIVAS Streptococcus pyogenes MGAS2096 cell division initiation protein DivIVA YP_600858.1 1219862 R 370565 CDS YP_600859.1 94992760 4065760 complement(1220630..1221421) 1 NC_008023.1 RNA binding protein 1221421 4065760 MGAS2096_Spy1263 Streptococcus pyogenes MGAS2096 RNA binding protein YP_600859.1 1220630 R 370565 CDS YP_600860.1 94992761 4065761 complement(1221421..1221675) 1 NC_008023.1 integral membrane protein 1221675 4065761 MGAS2096_Spy1264 Streptococcus pyogenes MGAS2096 integral membrane protein YP_600860.1 1221421 R 370565 CDS YP_600861.1 94992762 4065762 complement(1221680..1222348) 1 NC_008023.1 putative cytoplasmic protein 1222348 4065762 MGAS2096_Spy1265 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600861.1 1221680 R 370565 CDS YP_600862.1 94992763 4065763 complement(1222348..1223019) 1 NC_008023.1 pyridoxal-5'-phosphate family protein 1223019 4065763 MGAS2096_Spy1266 Streptococcus pyogenes MGAS2096 pyridoxal-5'-phosphate family protein YP_600862.1 1222348 R 370565 CDS YP_600863.1 94992764 4065764 complement(1223022..1224341) 1 NC_008023.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 1224341 ftsZ 4065764 ftsZ Streptococcus pyogenes MGAS2096 cell division protein FtsZ YP_600863.1 1223022 R 370565 CDS YP_600864.1 94992765 4065765 complement(1224365..1225729) 1 NC_008023.1 cell division protein ftsA 1225729 ftsA 4065765 ftsA Streptococcus pyogenes MGAS2096 cell division protein ftsA YP_600864.1 1224365 R 370565 CDS YP_600865.1 94992766 4065766 1225695..1225814 1 NC_008023.1 hypothetical protein 1225814 4065766 MGAS2096_Spy1268 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600865.1 1225695 D 370565 CDS YP_600866.1 94992767 4065767 complement(1225941..1227089) 1 NC_008023.1 cell-division initiation protein DivIB 1227089 divIB 4065767 divIB Streptococcus pyogenes MGAS2096 cell-division initiation protein DivIB YP_600866.1 1225941 R 370565 CDS YP_600867.1 94992768 4065768 complement(1227090..1228193) 1 NC_008023.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 1228193 murG 4065768 murG Streptococcus pyogenes MGAS2096 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_600867.1 1227090 R 370565 CDS YP_600868.1 94992769 4065769 complement(1228172..1229530) 1 NC_008023.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 1229530 murD 4065769 murD Streptococcus pyogenes MGAS2096 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_600868.1 1228172 R 370565 CDS YP_600869.1 94992770 4065770 complement(1229886..1230137) 1 NC_008023.1 hypothetical protein 1230137 4065770 MGAS2096_Spy1273 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600869.1 1229886 R 370565 CDS YP_600870.1 94992771 4064577 complement(1230259..1231875) 1 NC_008023.1 GTP-binding protein TypA/BipA 1231875 typA 4064577 typA Streptococcus pyogenes MGAS2096 GTP-binding protein TypA/BipA YP_600870.1 1230259 R 370565 CDS YP_600871.1 94992772 4064578 complement(1231898..1232101) 1 NC_008023.1 GTP-binding protein TypA/BipA 1232101 4064578 MGAS2096_Spy1275 Streptococcus pyogenes MGAS2096 GTP-binding protein TypA/BipA YP_600871.1 1231898 R 370565 CDS YP_600872.1 94992773 4064579 complement(1232283..1232672) 1 NC_008023.1 rhodanese-related sulfurtransferases 1232672 4064579 MGAS2096_Spy1276 Streptococcus pyogenes MGAS2096 rhodanese-related sulfurtransferases YP_600872.1 1232283 R 370565 CDS YP_600873.1 94992774 4064580 complement(1232682..1233653) 1 NC_008023.1 glucokinase 1233653 glcK 4064580 glcK Streptococcus pyogenes MGAS2096 glucokinase YP_600873.1 1232682 R 370565 CDS YP_600874.1 94992775 4064581 complement(1233658..1233879) 1 NC_008023.1 putative cytoplasmic protein 1233879 4064581 MGAS2096_Spy1278 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600874.1 1233658 R 370565 CDS YP_600875.1 94992776 4064582 complement(1234003..1234530) 1 NC_008023.1 non-specific DNA-binding protein Dps / Iron-binding ferritin-like antioxidant protein / ferroxidase 1234530 dpr 4064582 dpr Streptococcus pyogenes MGAS2096 non-specific DNA-binding protein Dps / Iron-binding ferritin-like antioxidant protein / ferroxidase YP_600875.1 1234003 R 370565 CDS YP_600876.1 94992777 4064583 1234758..1235384 1 NC_008023.1 Type 4 prepilin peptidase pilD 1235384 4064583 MGAS2096_Spy1280 Streptococcus pyogenes MGAS2096 Type 4 prepilin peptidase pilD YP_600876.1 1234758 D 370565 CDS YP_600877.1 94992778 4064584 complement(1235466..1236545) 1 NC_008023.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 1236545 4064584 MGAS2096_Spy1281 Streptococcus pyogenes MGAS2096 ribosomal RNA large subunit methyltransferase N YP_600877.1 1235466 R 370565 CDS YP_600878.1 94992779 4064585 complement(1236549..1237193) 1 NC_008023.1 putative cytoplasmic protein 1237193 4064585 MGAS2096_Spy1282 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600878.1 1236549 R 370565 CDS YP_600879.1 94992780 4064586 complement(1237464..1237586) 1 NC_008023.1 hypothetical protein 1237586 4064586 MGAS2096_Spy1283 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600879.1 1237464 R 370565 CDS YP_600880.1 94992781 4064587 complement(1237617..1238642) 1 NC_008023.1 ribose operon repressor 1238642 4064587 MGAS2096_Spy1284 Streptococcus pyogenes MGAS2096 ribose operon repressor YP_600880.1 1237617 R 370565 CDS YP_600881.1 94992782 4064588 complement(1238999..1240036) 1 NC_008023.1 ATP-dependent endopeptidase Lon 1240036 4064588 MGAS2096_Spy1285 Streptococcus pyogenes MGAS2096 ATP-dependent endopeptidase Lon YP_600881.1 1238999 R 370565 CDS YP_600882.1 94992783 4064589 complement(1240023..1240514) 1 NC_008023.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 1240514 coaD 4064589 coaD Streptococcus pyogenes MGAS2096 phosphopantetheine adenylyltransferase YP_600882.1 1240023 R 370565 CDS YP_600883.1 94992784 4064590 complement(1240504..1241043) 1 NC_008023.1 methyltransferase 1241043 4064590 MGAS2096_Spy1287 Streptococcus pyogenes MGAS2096 methyltransferase YP_600883.1 1240504 R 370565 CDS YP_600884.1 94992785 4064591 complement(1241166..1242158) 1 NC_008023.1 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 1242158 asnA 4064591 asnA Streptococcus pyogenes MGAS2096 asparagine synthetase AsnA YP_600884.1 1241166 R 370565 CDS YP_600885.1 94992786 4064592 complement(1242472..1243422) 1 NC_008023.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 1243422 arcC 4064592 arcC Streptococcus pyogenes MGAS2096 carbamate kinase YP_600885.1 1242472 R 370565 CDS YP_600886.1 94992787 4064593 complement(1243442..1244773) 1 NC_008023.1 hypothetical protein 1244773 4064593 MGAS2096_Spy1290 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600886.1 1243442 R 370565 CDS YP_600887.1 94992788 4064594 complement(1244790..1246283) 1 NC_008023.1 arginine/ornithine antiporter 1246283 4064594 MGAS2096_Spy1291 Streptococcus pyogenes MGAS2096 arginine/ornithine antiporter YP_600887.1 1244790 R 370565 CDS YP_600888.1 94992789 4064595 complement(1246453..1247466) 1 NC_008023.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase 1247466 arcB 4064595 arcB Streptococcus pyogenes MGAS2096 ornithine carbamoyltransferase YP_600888.1 1246453 R 370565 CDS YP_600889.1 94992790 4065097 complement(1247506..1247817) 1 NC_008023.1 acetyltransferase 1247817 4065097 MGAS2096_Spy1293 Streptococcus pyogenes MGAS2096 acetyltransferase YP_600889.1 1247506 R 370565 CDS YP_600890.1 94992791 4065098 complement(1247898..1249133) 1 NC_008023.1 catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase 1249133 arcA 4065098 arcA Streptococcus pyogenes MGAS2096 arginine deiminase YP_600890.1 1247898 R 370565 CDS YP_600891.1 94992792 4065099 complement(1249407..1250087) 1 NC_008023.1 Crp family transcriptional regulator 1250087 4065099 MGAS2096_Spy1295 Streptococcus pyogenes MGAS2096 Crp family transcriptional regulator YP_600891.1 1249407 R 370565 CDS YP_600892.1 94992793 4065100 1250229..1250702 1 NC_008023.1 arginine repressor ArgR 1250702 ahrC2 4065100 ahrC2 Streptococcus pyogenes MGAS2096 arginine repressor ArgR YP_600892.1 1250229 D 370565 CDS YP_600893.1 94992794 4065101 complement(1250868..1251584) 1 NC_008023.1 hypothetical protein 1251584 4065101 MGAS2096_Spy1297 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600893.1 1250868 R 370565 CDS YP_600894.1 94992795 4065102 complement(1251607..1252686) 1 NC_008023.1 putative cytoplasmic protein 1252686 4065102 MGAS2096_Spy1298 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600894.1 1251607 R 370565 CDS YP_600895.1 94992796 4065103 complement(1252759..1254492) 1 NC_008023.1 two-component sensor kinase yesM 1254492 4065103 MGAS2096_Spy1299 Streptococcus pyogenes MGAS2096 two-component sensor kinase yesM YP_600895.1 1252759 R 370565 CDS YP_600896.1 94992797 4065104 complement(1254489..1255229) 1 NC_008023.1 two-component response regulator yesN 1255229 4065104 MGAS2096_Spy1300 Streptococcus pyogenes MGAS2096 two-component response regulator yesN YP_600896.1 1254489 R 370565 CDS YP_600897.1 94992798 4065105 complement(1255317..1256423) 1 NC_008023.1 bifunctional methionine sulfoxide reductase A/B 1256423 msrA 4065105 msrA Streptococcus pyogenes MGAS2096 bifunctional methionine sulfoxide reductase A/B YP_600897.1 1255317 R 370565 CDS YP_600898.1 94992799 4065106 complement(1256466..1257089) 1 NC_008023.1 Thiol:disulfide interchange protein tlpA 1257089 tlpA 4065106 tlpA Streptococcus pyogenes MGAS2096 Thiol:disulfide interchange protein tlpA YP_600898.1 1256466 R 370565 CDS YP_600899.1 94992800 4065107 complement(1257102..1257812) 1 NC_008023.1 cytochrome c-type biogenesis protein ccdA 1257812 ccdA 4065107 ccdA Streptococcus pyogenes MGAS2096 cytochrome c-type biogenesis protein ccdA YP_600899.1 1257102 R 370565 CDS YP_600900.1 94992801 4065108 complement(1258552..1258845) 1 NC_008023.1 putative cytoplasmic protein 1258845 4065108 MGAS2096_Spy1304 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600900.1 1258552 R 370565 CDS YP_600901.1 94992802 4065109 complement(1258856..1259881) 1 NC_008023.1 hypothetical protein 1259881 4065109 MGAS2096_Spy1305 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600901.1 1258856 R 370565 CDS YP_600902.1 94992803 4065110 complement(1259878..1260552) 1 NC_008023.1 hypothetical protein 1260552 4065110 MGAS2096_Spy1306 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600902.1 1259878 R 370565 CDS YP_600903.1 94992804 4065111 complement(1260554..1261417) 1 NC_008023.1 putative cytoplasmic protein 1261417 4065111 MGAS2096_Spy1307 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600903.1 1260554 R 370565 CDS YP_600904.1 94992805 4065112 complement(1261407..1263302) 1 NC_008023.1 hypothetical protein 1263302 4065112 MGAS2096_Spy1308 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600904.1 1261407 R 370565 CDS YP_600905.1 94992806 4065113 complement(1263302..1264030) 1 NC_008023.1 hypothetical protein 1264030 4065113 MGAS2096_Spy1309 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600905.1 1263302 R 370565 CDS YP_600906.1 94992807 4065114 complement(1264163..1266571) 1 NC_008023.1 ATP-dependent RNA helicase 1266571 4065114 MGAS2096_Spy1310 Streptococcus pyogenes MGAS2096 ATP-dependent RNA helicase YP_600906.1 1264163 R 370565 CDS YP_600907.1 94992808 4065115 complement(1266725..1269373) 1 NC_008023.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 1269373 valS 4065115 valS Streptococcus pyogenes MGAS2096 valyl-tRNA synthetase YP_600907.1 1266725 R 370565 CDS YP_600908.1 94992809 4065116 complement(1269375..1269959) 1 NC_008023.1 hypothetical protein 1269959 4065116 MGAS2096_Spy1312 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600908.1 1269375 R 370565 CDS YP_600909.1 94992810 4064502 complement(1269935..1270114) 1 NC_008023.1 ribosomal-protein-serine acetyltransferase 1270114 4064502 MGAS2096_Spy1313 Streptococcus pyogenes MGAS2096 ribosomal-protein-serine acetyltransferase YP_600909.1 1269935 R 370565 CDS YP_600910.1 94992811 4064503 complement(1270539..1270934) 1 NC_008023.1 putative cytoplasmic protein 1270934 4064503 MGAS2096_Spy1314 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600910.1 1270539 R 370565 CDS YP_600911.1 94992812 4064504 complement(1270955..1271209) 1 NC_008023.1 hypothetical protein 1271209 4064504 MGAS2096_Spy1315 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600911.1 1270955 R 370565 CDS YP_600912.1 94992813 4064506 1271686..1272438 1 NC_008023.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; 3-deoxy-7-phosphoheptulonate synthase 1272438 4064506 MGAS2096_Spy1316 Streptococcus pyogenes MGAS2096 3-deoxy-7-phosphoheptulonate synthase YP_600912.1 1271686 D 370565 CDS YP_600913.1 94992814 4064507 1272479..1273567 1 NC_008023.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 1273567 aroB 4064507 aroB Streptococcus pyogenes MGAS2096 3-dehydroquinate synthase YP_600913.1 1272479 D 370565 CDS YP_600914.1 94992815 4064508 complement(1273852..1273995) 1 NC_008023.1 hypothetical protein 1273995 4064508 MGAS2096_Spy1318 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600914.1 1273852 R 370565 CDS YP_600915.1 94992816 4064509 complement(1274003..1274308) 1 NC_008023.1 putative acetate kinase 1274308 4064509 MGAS2096_Spy1319 Streptococcus pyogenes MGAS2096 putative acetate kinase YP_600915.1 1274003 R 370565 CDS YP_600916.1 94992817 4064510 complement(1274310..1274648) 1 NC_008023.1 putative cytoplasmic protein 1274648 4064510 MGAS2096_Spy1320 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600916.1 1274310 R 370565 CDS YP_600917.1 94992818 4064511 complement(1274701..1275456) 1 NC_008023.1 SAM-dependent methyltransferase 1275456 4064511 MGAS2096_Spy1321 Streptococcus pyogenes MGAS2096 SAM-dependent methyltransferase YP_600917.1 1274701 R 370565 CDS YP_600918.1 94992819 4064512 1275553..1275660 1 NC_008023.1 hypothetical protein 1275660 4064512 MGAS2096_Spy1322 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600918.1 1275553 D 370565 CDS YP_600919.1 94992820 4064513 complement(1275691..1276569) 1 NC_008023.1 shikimate 5-dehydrogenase 1276569 aroE 4064513 aroE Streptococcus pyogenes MGAS2096 shikimate 5-dehydrogenase YP_600919.1 1275691 R 370565 CDS YP_600920.1 94992821 4064514 complement(1276707..1280213) 1 NC_008023.1 beta-galactosidase 1280213 lacZ 4064514 lacZ Streptococcus pyogenes MGAS2096 beta-galactosidase YP_600920.1 1276707 R 370565 CDS YP_600921.1 94992822 4064515 complement(1280143..1281630) 1 NC_008023.1 two-component response regulator yesN 1281630 4064515 MGAS2096_Spy1325 Streptococcus pyogenes MGAS2096 two-component response regulator yesN YP_600921.1 1280143 R 370565 CDS YP_600922.1 94992823 4064516 complement(1281627..1283354) 1 NC_008023.1 two-component sensor kinase yesM 1283354 4064516 MGAS2096_Spy1326 Streptococcus pyogenes MGAS2096 two-component sensor kinase yesM YP_600922.1 1281627 R 370565 CDS YP_600923.1 94992824 4064517 complement(1283341..1283946) 1 NC_008023.1 hypothetical protein 1283946 4064517 MGAS2096_Spy1327 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600923.1 1283341 R 370565 CDS YP_600924.1 94992825 4064518 complement(1284251..1285696) 1 NC_008023.1 sugar-binding protein 1285696 4064518 MGAS2096_Spy1328 Streptococcus pyogenes MGAS2096 sugar-binding protein YP_600924.1 1284251 R 370565 CDS YP_600925.1 94992826 4064519 complement(1285777..1286703) 1 NC_008023.1 sugar transport system permease 1286703 4064519 MGAS2096_Spy1329 Streptococcus pyogenes MGAS2096 sugar transport system permease YP_600925.1 1285777 R 370565 CDS YP_600926.1 94992827 4064520 complement(1286713..1287711) 1 NC_008023.1 sugar transport system permease 1287711 4064520 MGAS2096_Spy1330 Streptococcus pyogenes MGAS2096 sugar transport system permease YP_600926.1 1286713 R 370565 CDS YP_600927.1 94992828 4064521 1287814..1288737 1 NC_008023.1 RpiR family transcriptional regulator 1288737 4064521 MGAS2096_Spy1331 Streptococcus pyogenes MGAS2096 RpiR family transcriptional regulator YP_600927.1 1287814 D 370565 CDS YP_600928.1 94992829 4064522 1288880..1289002 1 NC_008023.1 hypothetical protein 1289002 4064522 MGAS2096_Spy1332 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600928.1 1288880 D 370565 CDS YP_600929.1 94992830 4064523 complement(1289348..1290790) 1 NC_008023.1 Beta-glucosidase 1290790 4064523 MGAS2096_Spy1333 Streptococcus pyogenes MGAS2096 Beta-glucosidase YP_600929.1 1289348 R 370565 CDS YP_600930.1 94992831 4064524 complement(1290815..1291954) 1 NC_008023.1 hyaluronoglucosaminidase 1291954 hyl 4064524 hyl Streptococcus pyogenes MGAS2096 hyaluronoglucosaminidase YP_600930.1 1290815 R 370565 CDS YP_600931.1 94992832 4064525 complement(1291951..1292508) 1 NC_008023.1 putative cytoplasmic protein 1292508 4064525 MGAS2096_Spy1335 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_600931.1 1291951 R 370565 CDS YP_600932.1 94992833 4064526 complement(1292559..1293599) 1 NC_008023.1 GntR family transcriptional regulator 1293599 4064526 MGAS2096_Spy1336 Streptococcus pyogenes MGAS2096 GntR family transcriptional regulator YP_600932.1 1292559 R 370565 CDS YP_600933.1 94992834 4064527 1293705..1295018 1 NC_008023.1 hypothetical protein 1295018 4064527 MGAS2096_Spy1337 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600933.1 1293705 D 370565 CDS YP_600934.1 94992835 4064528 1295033..1297738 1 NC_008023.1 Alpha-mannosidase 1297738 4064528 MGAS2096_Spy1338 Streptococcus pyogenes MGAS2096 Alpha-mannosidase YP_600934.1 1295033 D 370565 CDS YP_600935.1 94992836 4064529 complement(1297839..1299137) 1 NC_008023.1 sensory transduction protein kinase 1299137 rocA 4064529 rocA Streptococcus pyogenes MGAS2096 sensory transduction protein kinase YP_600935.1 1297839 R 370565 CDS YP_600936.1 94992837 4064530 complement(1299859..1301214) 1 NC_008023.1 tRNA (Uracil-5-) -methyltransferase 1301214 4064530 MGAS2096_Spy1340 Streptococcus pyogenes MGAS2096 tRNA (Uracil-5-) -methyltransferase YP_600936.1 1299859 R 370565 CDS YP_600937.1 94992838 4064531 1301329..1302105 1 NC_008023.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1302105 recX 4064531 recX Streptococcus pyogenes MGAS2096 recombination regulator RecX YP_600937.1 1301329 D 370565 CDS YP_600938.1 94992839 4064532 1302185..1302718 1 NC_008023.1 hypothetical protein 1302718 4064532 MGAS2096_Spy1342 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600938.1 1302185 D 370565 CDS YP_600939.1 94992840 4064533 1302850..1302975 1 NC_008023.1 hypothetical protein 1302975 4064533 MGAS2096_Spy1343 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600939.1 1302850 D 370565 CDS YP_600940.1 94992841 4064534 1303090..1303476 1 NC_008023.1 transposase 1303476 4064534 MGAS2096_Spy1344 Streptococcus pyogenes MGAS2096 transposase YP_600940.1 1303090 D 370565 CDS YP_600941.1 94992842 4065330 1309657..1309881 1 NC_008023.1 hypothetical protein 1309881 4065330 MGAS2096_Spy1345 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600941.1 1309657 D 370565 CDS YP_600942.1 94992843 4065331 complement(1310475..1311023) 1 NC_008023.1 ribosome-associated factor Y 1311023 4065331 MGAS2096_Spy1346 Streptococcus pyogenes MGAS2096 ribosome-associated factor Y YP_600942.1 1310475 R 370565 CDS YP_600943.1 94992844 4064713 complement(1311103..1311768) 1 NC_008023.1 COMF operon protein 3 1311768 comFC 4064713 comFC Streptococcus pyogenes MGAS2096 COMF operon protein 3 YP_600943.1 1311103 R 370565 CDS YP_600944.1 94992845 4064714 complement(1311740..1313065) 1 NC_008023.1 COMF operon protein 1 1313065 comFA 4064714 comFA Streptococcus pyogenes MGAS2096 COMF operon protein 1 YP_600944.1 1311740 R 370565 CDS YP_600945.1 94992846 4064715 1313105..1313752 1 NC_008023.1 Xaa-Pro dipeptidase 1313752 4064715 MGAS2096_Spy1349 Streptococcus pyogenes MGAS2096 Xaa-Pro dipeptidase YP_600945.1 1313105 D 370565 CDS YP_600946.1 94992847 4064716 1313880..1314821 1 NC_008023.1 cysteine synthase 1314821 cysM 4064716 cysM Streptococcus pyogenes MGAS2096 cysteine synthase YP_600946.1 1313880 D 370565 CDS YP_600947.1 94992848 4064717 complement(1314839..1315216) 1 NC_008023.1 hypothetical protein 1315216 4064717 MGAS2096_Spy1351 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600947.1 1314839 R 370565 CDS YP_600948.1 94992849 4064718 complement(1315216..1316628) 1 NC_008023.1 peptidyl-prolyl cis-trans isomerase 1316628 4064718 MGAS2096_Spy1352 Streptococcus pyogenes MGAS2096 peptidyl-prolyl cis-trans isomerase YP_600948.1 1315216 R 370565 CDS YP_600949.1 94992850 4064719 complement(1316653..1317300) 1 NC_008023.1 two-component response regulator yvqC 1317300 yvqC 4064719 yvqC Streptococcus pyogenes MGAS2096 two-component response regulator yvqC YP_600949.1 1316653 R 370565 CDS YP_600950.1 94992851 4064720 complement(1317287..1318291) 1 NC_008023.1 two-component sensor protein yvqE 1318291 yvqE 4064720 yvqE Streptococcus pyogenes MGAS2096 two-component sensor protein yvqE YP_600950.1 1317287 R 370565 CDS YP_600951.1 94992852 4064721 complement(1318288..1319031) 1 NC_008023.1 transporter yvqF 1319031 yvqF 4064721 yvqF Streptococcus pyogenes MGAS2096 transporter yvqF YP_600951.1 1318288 R 370565 CDS YP_600952.1 94992853 4064722 complement(1319103..1321001) 1 NC_008023.1 Serine/threonine protein kinase 1321001 4064722 MGAS2096_Spy1356 Streptococcus pyogenes MGAS2096 Serine/threonine protein kinase YP_600952.1 1319103 R 370565 CDS YP_600953.1 94992854 4064723 complement(1320998..1321738) 1 NC_008023.1 protein phosphatase 2C 1321738 pppL 4064723 pppL Streptococcus pyogenes MGAS2096 protein phosphatase 2C YP_600953.1 1320998 R 370565 CDS YP_600954.1 94992855 4064724 complement(1321776..1323098) 1 NC_008023.1 16S rRNA m(5)C 967 methyltransferase 1323098 sunL 4064724 sunL Streptococcus pyogenes MGAS2096 16S rRNA m(5)C 967 methyltransferase YP_600954.1 1321776 R 370565 CDS YP_600955.1 94992856 4064725 complement(1323088..1324023) 1 NC_008023.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 1324023 fmt 4064725 fmt Streptococcus pyogenes MGAS2096 methionyl-tRNA formyltransferase YP_600955.1 1323088 R 370565 CDS YP_600956.1 94992857 4064726 complement(1324085..1326496) 1 NC_008023.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 1326496 priA 4064726 priA Streptococcus pyogenes MGAS2096 primosome assembly protein PriA YP_600956.1 1324085 R 370565 CDS YP_600957.1 94992858 4064727 complement(1326534..1326851) 1 NC_008023.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 1326851 4064727 MGAS2096_Spy1361 Streptococcus pyogenes MGAS2096 DNA-directed RNA polymerase subunit omega YP_600957.1 1326534 R 370565 CDS YP_600958.1 94992859 4064728 complement(1326867..1327502) 1 NC_008023.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1327502 gmk 4064728 gmk Streptococcus pyogenes MGAS2096 guanylate kinase YP_600958.1 1326867 R 370565 CDS YP_600959.1 94992860 4064729 complement(1327612..1329219) 1 NC_008023.1 HAD superfamily; hypothetical protein 1329219 4064729 MGAS2096_Spy1363 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600959.1 1327612 R 370565 CDS YP_600960.1 94992861 4064730 complement(1329349..1330269) 1 NC_008023.1 LysR family transcriptional regulator 1330269 4064730 MGAS2096_Spy1364 Streptococcus pyogenes MGAS2096 LysR family transcriptional regulator YP_600960.1 1329349 R 370565 CDS YP_600961.1 94992862 4064731 1330446..1331633 1 NC_008023.1 Acetyl-CoA acetyltransferase 1331633 atoB 4064731 atoB Streptococcus pyogenes MGAS2096 Acetyl-CoA acetyltransferase YP_600961.1 1330446 D 370565 CDS YP_600962.1 94992863 4065195 1331645..1332307 1 NC_008023.1 acetate CoA-transferase subunit alpha 1332307 atoD1 4065195 atoD1 Streptococcus pyogenes MGAS2096 acetate CoA-transferase subunit alpha YP_600962.1 1331645 D 370565 CDS YP_600963.1 94992864 4065196 1332309..1332968 1 NC_008023.1 acetate CoA-transferase subunit beta 1332968 atoA 4065196 atoA Streptococcus pyogenes MGAS2096 acetate CoA-transferase subunit beta YP_600963.1 1332309 D 370565 CDS YP_600964.1 94992865 4065197 1333020..1333778 1 NC_008023.1 catalyzes the formation of acetoacetate from 3-hydroxybutyrate; 3-hydroxybutyrate dehydrogenase 1333778 4065197 MGAS2096_Spy1368 Streptococcus pyogenes MGAS2096 3-hydroxybutyrate dehydrogenase YP_600964.1 1333020 D 370565 CDS YP_600965.1 94992866 4065198 1333849..1334289 1 NC_008023.1 D-beta-hydroxybutyrate permease 1334289 4065198 MGAS2096_Spy1369 Streptococcus pyogenes MGAS2096 D-beta-hydroxybutyrate permease YP_600965.1 1333849 D 370565 CDS YP_600966.1 94992867 4065199 1334335..1335180 1 NC_008023.1 D-beta-hydroxybutyrate permease 1335180 4065199 MGAS2096_Spy1370 Streptococcus pyogenes MGAS2096 D-beta-hydroxybutyrate permease YP_600966.1 1334335 D 370565 CDS YP_600967.1 94992868 4065200 1335164..1335736 1 NC_008023.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 1335736 luxS 4065200 luxS Streptococcus pyogenes MGAS2096 S-ribosylhomocysteinase YP_600967.1 1335164 D 370565 CDS YP_600968.1 94992869 4065201 complement(1335882..1337351) 1 NC_008023.1 hypothetical protein 1337351 4065201 MGAS2096_Spy1372 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600968.1 1335882 R 370565 CDS YP_600969.1 94992870 4065202 complement(1337365..1338519) 1 NC_008023.1 methyltransferase 1338519 4065202 MGAS2096_Spy1373 Streptococcus pyogenes MGAS2096 methyltransferase YP_600969.1 1337365 R 370565 CDS YP_600970.1 94992871 4065203 complement(1338964..1339290) 1 NC_008023.1 cell division initiation protein DivIVA 1339290 4065203 MGAS2096_Spy1374 Streptococcus pyogenes MGAS2096 cell division initiation protein DivIVA YP_600970.1 1338964 R 370565 CDS YP_600971.1 94992872 4065204 complement(1339412..1339927) 1 NC_008023.1 hypothetical protein 1339927 4065204 MGAS2096_Spy1375 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600971.1 1339412 R 370565 CDS YP_600972.1 94992873 4065205 1340008..1340616 1 NC_008023.1 functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC; Holliday junction-specific endonuclease 1340616 recU 4065205 recU Streptococcus pyogenes MGAS2096 Holliday junction-specific endonuclease YP_600972.1 1340008 D 370565 CDS YP_600973.1 94992874 4065206 1340603..1342768 1 NC_008023.1 multimodular transpeptidase-transglycosylase PBP 1A 1342768 pbp1A 4065206 pbp1A Streptococcus pyogenes MGAS2096 multimodular transpeptidase-transglycosylase PBP 1A YP_600973.1 1340603 D 370565 CDS YP_600974.1 94992875 4065207 complement(1343232..1344569) 1 NC_008023.1 aminopeptidase C 1344569 pepC 4065207 pepC Streptococcus pyogenes MGAS2096 aminopeptidase C YP_600974.1 1343232 R 370565 CDS YP_600975.1 94992876 4065208 complement(1344754..1345620) 1 NC_008023.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1345620 nadE 4065208 nadE Streptococcus pyogenes MGAS2096 NAD synthetase YP_600975.1 1344754 R 370565 CDS YP_600976.1 94992877 4065209 complement(1345580..1347034) 1 NC_008023.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 1347034 nadE 4065209 nadE Streptococcus pyogenes MGAS2096 nicotinate phosphoribosyltransferase YP_600976.1 1345580 R 370565 CDS YP_600977.1 94992878 4065210 complement(1347205..1348596) 1 NC_008023.1 amino acid permease 1348596 4065210 MGAS2096_Spy1381 Streptococcus pyogenes MGAS2096 amino acid permease YP_600977.1 1347205 R 370565 CDS YP_600978.1 94992879 4065211 complement(1348753..1349670) 1 NC_008023.1 thioredoxin reductase 1349670 4065211 MGAS2096_Spy1382 Streptococcus pyogenes MGAS2096 thioredoxin reductase YP_600978.1 1348753 R 370565 CDS YP_600979.1 94992880 4065212 complement(1349734..1349958) 1 NC_008023.1 hypothetical protein 1349958 aapA 4065212 aapA Streptococcus pyogenes MGAS2096 hypothetical protein YP_600979.1 1349734 R 370565 CDS YP_600980.1 94992881 4065213 complement(1350062..1350808) 1 NC_008023.1 amino acid ABC transporter ATP-binding protein 1350808 4065213 MGAS2096_Spy1384 Streptococcus pyogenes MGAS2096 amino acid ABC transporter ATP-binding protein YP_600980.1 1350062 R 370565 CDS YP_600981.1 94992882 4065214 complement(1350805..1351698) 1 NC_008023.1 amino acid ABC transporter permease 1351698 4065214 MGAS2096_Spy1385 Streptococcus pyogenes MGAS2096 amino acid ABC transporter permease YP_600981.1 1350805 R 370565 CDS YP_600982.1 94992883 4066307 complement(1351803..1353146) 1 NC_008023.1 ATP-dependent RNA helicase 1353146 4066307 MGAS2096_Spy1387 Streptococcus pyogenes MGAS2096 ATP-dependent RNA helicase YP_600982.1 1351803 R 370565 CDS YP_600983.1 94992884 4066308 1353145..1353294 1 NC_008023.1 hypothetical protein 1353294 4066308 MGAS2096_Spy1386 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600983.1 1353145 D 370565 CDS YP_600984.1 94992885 4066309 complement(1353304..1354314) 1 NC_008023.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 1354314 mraY 4066309 mraY Streptococcus pyogenes MGAS2096 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_600984.1 1353304 R 370565 CDS YP_600985.1 94992886 4066310 complement(1354316..1356571) 1 NC_008023.1 division specific D,D-transpeptidase / cell division protein ftsI 1356571 4066310 MGAS2096_Spy1389 Streptococcus pyogenes MGAS2096 division specific D,D-transpeptidase / cell division protein ftsI YP_600985.1 1354316 R 370565 CDS YP_600986.1 94992887 4066311 complement(1356575..1356928) 1 NC_008023.1 cell division protein ftsL 1356928 ftsL 4066311 ftsL Streptococcus pyogenes MGAS2096 cell division protein ftsL YP_600986.1 1356575 R 370565 CDS YP_600987.1 94992888 4066312 complement(1356903..1357916) 1 NC_008023.1 S-adenosyl-methyltransferase MraW 1357916 mraW 4066312 mraW Streptococcus pyogenes MGAS2096 S-adenosyl-methyltransferase MraW YP_600987.1 1356903 R 370565 CDS YP_600988.1 94992889 4066313 complement(1358146..1358412) 1 NC_008023.1 hypothetical protein 1358412 4066313 MGAS2096_Spy1392 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600988.1 1358146 R 370565 CDS YP_600989.1 94992890 4066314 complement(1358387..1359637) 1 NC_008023.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 1359637 proA 4066314 proA Streptococcus pyogenes MGAS2096 gamma-glutamyl phosphate reductase YP_600989.1 1358387 R 370565 CDS YP_600990.1 94992891 4066315 complement(1359630..1360457) 1 NC_008023.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 1360457 4066315 MGAS2096_Spy1394 Streptococcus pyogenes MGAS2096 gamma-glutamyl kinase YP_600990.1 1359630 R 370565 CDS YP_600991.1 94992892 4066316 complement(1360515..1362185) 1 NC_008023.1 ABC transporter permease 1362185 proB 4066316 proB Streptococcus pyogenes MGAS2096 ABC transporter permease YP_600991.1 1360515 R 370565 CDS YP_600992.1 94992893 4066317 complement(1362148..1362882) 1 NC_008023.1 ABC transporter ATP-binding protein 1362882 4066317 MGAS2096_Spy1396 Streptococcus pyogenes MGAS2096 ABC transporter ATP-binding protein YP_600992.1 1362148 R 370565 CDS YP_600993.1 94992894 4066318 complement(1362916..1363182) 1 NC_008023.1 hypothetical protein 1363182 4066318 MGAS2096_Spy1397 Streptococcus pyogenes MGAS2096 hypothetical protein YP_600993.1 1362916 R 370565 CDS YP_600994.2 162139128 4066319 complement(1363375..1365360) 1 NC_008023.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1365360 tkt 4066319 tkt Streptococcus pyogenes MGAS2096 transketolase YP_600994.2 1363375 R 370565 CDS YP_600995.1 94992896 4066320 complement(1365578..1366222) 1 NC_008023.1 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity; putative translaldolase 1366222 4066320 MGAS2096_Spy1399 Streptococcus pyogenes MGAS2096 putative translaldolase YP_600995.1 1365578 R 370565 CDS YP_600996.1 94992897 4066321 complement(1366348..1367907) 1 NC_008023.1 trans-acting positive regulator 1367907 4066321 MGAS2096_Spy1400 Streptococcus pyogenes MGAS2096 trans-acting positive regulator YP_600996.1 1366348 R 370565 CDS YP_600997.1 94992898 4066322 complement(1367837..1369276) 1 NC_008023.1 NADH peroxidase 1369276 4066322 MGAS2096_Spy1401 Streptococcus pyogenes MGAS2096 NADH peroxidase YP_600997.1 1367837 R 370565 CDS YP_600998.1 94992899 4066323 complement(1369292..1369993) 1 NC_008023.1 glycerol uptake facilitator protein 1369993 glpF 4066323 glpF Streptococcus pyogenes MGAS2096 glycerol uptake facilitator protein YP_600998.1 1369292 R 370565 CDS YP_600999.1 94992900 4066324 complement(1369995..1371833) 1 NC_008023.1 Alpha-glycerophosphate oxidase 1371833 glpO 4066324 glpO Streptococcus pyogenes MGAS2096 Alpha-glycerophosphate oxidase YP_600999.1 1369995 R 370565 CDS YP_601000.1 94992901 4066325 complement(1371849..1373375) 1 NC_008023.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 1373375 glpK 4066325 glpK Streptococcus pyogenes MGAS2096 glycerol kinase YP_601000.1 1371849 R 370565 CDS YP_601001.1 94992902 4064844 complement(1373735..1374187) 1 NC_008023.1 hypothetical protein 1374187 4064844 MGAS2096_Spy1405 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601001.1 1373735 R 370565 CDS YP_601002.1 94992903 4064845 complement(1374254..1374511) 1 NC_008023.1 hypothetical protein 1374511 4064845 MGAS2096_Spy1406 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601002.1 1374254 R 370565 CDS YP_601003.1 94992904 4064846 complement(1374665..1376617) 1 NC_008023.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 1376617 glyS 4064846 glyS Streptococcus pyogenes MGAS2096 glycyl-tRNA synthetase subunit beta YP_601003.1 1374665 R 370565 CDS YP_601004.1 94992905 4064847 complement(1377081..1377998) 1 NC_008023.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 1377998 glyQ 4064847 glyQ Streptococcus pyogenes MGAS2096 glycyl-tRNA synthetase subunit alpha YP_601004.1 1377081 R 370565 CDS YP_601005.1 94992906 4064848 complement(1377962..1378168) 1 NC_008023.1 hypothetical protein 1378168 4064848 MGAS2096_Spy1409 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601005.1 1377962 R 370565 CDS YP_601006.1 94992907 4064849 complement(1378369..1378923) 1 NC_008023.1 hypothetical protein 1378923 4064849 MGAS2096_Spy1410 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601006.1 1378369 R 370565 CDS YP_601007.1 94992908 4064850 complement(1379034..1379876) 1 NC_008023.1 aldo/keto reductase 1379876 4064850 MGAS2096_Spy1411 Streptococcus pyogenes MGAS2096 aldo/keto reductase YP_601007.1 1379034 R 370565 CDS YP_601008.1 94992909 4064851 complement(1379995..1381143) 1 NC_008023.1 N-acetylglucosamine-6-phosphate deacetylase 1381143 nagA 4064851 nagA Streptococcus pyogenes MGAS2096 N-acetylglucosamine-6-phosphate deacetylase YP_601008.1 1379995 R 370565 CDS YP_601009.1 94992910 4064852 complement(1381261..1382910) 1 NC_008023.1 Sodium-dependent phosphate transporter 1382910 4064852 MGAS2096_Spy1413 Streptococcus pyogenes MGAS2096 Sodium-dependent phosphate transporter YP_601009.1 1381261 R 370565 CDS YP_601010.1 94992911 4064853 complement(1382950..1383117) 1 NC_008023.1 hypothetical protein 1383117 4064853 MGAS2096_Spy1415 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601010.1 1382950 R 370565 CDS YP_601011.1 94992912 4064854 1383094..1383816 1 NC_008023.1 hypothetical protein 1383816 4064854 MGAS2096_Spy1414 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601011.1 1383094 D 370565 CDS YP_601012.1 94992913 4064855 complement(1383962..1384786) 1 NC_008023.1 DegV family protein 1384786 4064855 MGAS2096_Spy1416 Streptococcus pyogenes MGAS2096 DegV family protein YP_601012.1 1383962 R 370565 CDS YP_601013.1 94992914 4064856 1385076..1385636 1 NC_008023.1 TetR family transcriptional regulator 1385636 4064856 MGAS2096_Spy1417 Streptococcus pyogenes MGAS2096 TetR family transcriptional regulator YP_601013.1 1385076 D 370565 CDS YP_601014.1 94992915 4064857 complement(1385672..1386553) 1 NC_008023.1 HAD superfamily; hydrolase 1386553 4064857 MGAS2096_Spy1418 Streptococcus pyogenes MGAS2096 hydrolase YP_601014.1 1385672 R 370565 CDS YP_601015.1 94992916 4064858 complement(1386498..1387115) 1 NC_008023.1 hypothetical protein 1387115 4064858 MGAS2096_Spy1419 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601015.1 1386498 R 370565 CDS YP_601016.1 94992917 4064859 complement(1387312..1388289) 1 NC_008023.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; tagatose 1,6-diphosphate aldolase 1388289 lacD1 4064859 lacD1 Streptococcus pyogenes MGAS2096 tagatose 1,6-diphosphate aldolase YP_601016.1 1387312 R 370565 CDS YP_601017.1 94992918 4064860 complement(1388371..1388634) 1 NC_008023.1 tagatose-6-phosphate kinase 1388634 4064860 MGAS2096_Spy1421 Streptococcus pyogenes MGAS2096 tagatose-6-phosphate kinase YP_601017.1 1388371 R 370565 CDS YP_601018.1 94992919 4064861 complement(1388788..1389204) 1 NC_008023.1 galactose-6-phosphate isomerase subunit LacB 1389204 lacB1 4064861 lacB1 Streptococcus pyogenes MGAS2096 galactose-6-phosphate isomerase subunit LacB YP_601018.1 1388788 R 370565 CDS YP_601019.1 94992920 4064862 complement(1389219..1389644) 1 NC_008023.1 catalyzes the interconversion of galactose 6-phosphate to tagatose; galactose-6-phosphate isomerase subunit LacA 1389644 lacA1 4064862 lacA1 Streptococcus pyogenes MGAS2096 galactose-6-phosphate isomerase subunit LacA YP_601019.1 1389219 R 370565 CDS YP_601020.1 94992921 4064863 1389723..1389899 1 NC_008023.1 putative transcriptional regulator 1389899 4064863 MGAS2096_Spy1424 Streptococcus pyogenes MGAS2096 putative transcriptional regulator YP_601020.1 1389723 D 370565 CDS YP_601021.1 94992922 4066459 complement(1389902..1390333) 1 NC_008023.1 PTS system galactose-specific transporter subunit IIC 1390333 4066459 MGAS2096_Spy1425 Streptococcus pyogenes MGAS2096 PTS system galactose-specific transporter subunit IIC YP_601021.1 1389902 R 370565 CDS YP_601022.1 94992923 4066460 complement(1390330..1391352) 1 NC_008023.1 PTS system galactose-specific transporter subunit IIC 1391352 4066460 MGAS2096_Spy1426 Streptococcus pyogenes MGAS2096 PTS system galactose-specific transporter subunit IIC YP_601022.1 1390330 R 370565 CDS YP_601023.1 94992924 4066461 complement(1391378..1391683) 1 NC_008023.1 PTS system galactose-specific transporter subunit IIB 1391683 4066461 MGAS2096_Spy1427 Streptococcus pyogenes MGAS2096 PTS system galactose-specific transporter subunit IIB YP_601023.1 1391378 R 370565 CDS YP_601024.1 94992925 4066462 complement(1391676..1392035) 1 NC_008023.1 PTS system galactose-specific transporter subunit IIA 1392035 4066462 MGAS2096_Spy1428 Streptococcus pyogenes MGAS2096 PTS system galactose-specific transporter subunit IIA YP_601024.1 1391676 R 370565 CDS YP_601025.1 94992926 4066463 1392385..1393155 1 NC_008023.1 lactose phosphotransferase system repressor 1393155 lacR1 4066463 lacR1 Streptococcus pyogenes MGAS2096 lactose phosphotransferase system repressor YP_601025.1 1392385 D 370565 CDS YP_601026.1 94992927 4066464 complement(1393355..1393558) 1 NC_008023.1 copper chaperone copZ 1393558 copZ 4066464 copZ Streptococcus pyogenes MGAS2096 copper chaperone copZ YP_601026.1 1393355 R 370565 CDS YP_601027.1 94992928 4066465 complement(1393572..1395848) 1 NC_008023.1 copper-exporting ATPase 1395848 copA 4066465 copA Streptococcus pyogenes MGAS2096 copper-exporting ATPase YP_601027.1 1393572 R 370565 CDS YP_601028.1 94992929 4066466 complement(1395803..1396255) 1 NC_008023.1 CopAB ATPase metal-fist type repressor 1396255 copY 4066466 copY Streptococcus pyogenes MGAS2096 CopAB ATPase metal-fist type repressor YP_601028.1 1395803 R 370565 CDS YP_601029.1 94992930 4066467 1396409..1397398 1 NC_008023.1 esterase 1397398 4066467 MGAS2096_Spy1433 Streptococcus pyogenes MGAS2096 esterase YP_601029.1 1396409 D 370565 CDS YP_601030.1 94992931 4066468 complement(1397529..1397885) 1 NC_008023.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 1397885 rbfA 4066468 rbfA Streptococcus pyogenes MGAS2096 ribosome-binding factor A YP_601030.1 1397529 R 370565 CDS YP_601031.1 94992932 4066469 complement(1398085..1400946) 1 NC_008023.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 1400946 infB 4066469 infB Streptococcus pyogenes MGAS2096 translation initiation factor IF-2 YP_601031.1 1398085 R 370565 CDS YP_601032.1 94992933 4066470 complement(1400966..1401268) 1 NC_008023.1 hypothetical protein 1401268 4066470 MGAS2096_Spy1436 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601032.1 1400966 R 370565 CDS YP_601033.1 94992934 4066471 complement(1401261..1401560) 1 NC_008023.1 putative cytoplasmic protein 1401560 4066471 MGAS2096_Spy1437 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_601033.1 1401261 R 370565 CDS YP_601034.2 162139127 4066472 complement(1401573..1402730) 1 NC_008023.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 1402730 nusA 4066472 nusA Streptococcus pyogenes MGAS2096 transcription elongation factor NusA YP_601034.2 1401573 R 370565 CDS YP_601035.1 94992936 4066473 complement(1402905..1403441) 1 NC_008023.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 1403441 4066473 MGAS2096_Spy1439 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601035.1 1402905 R 370565 CDS YP_601036.1 94992937 4066474 complement(1403686..1403865) 1 NC_008023.1 phage protein 1403865 4066474 MGAS2096_Spy1440 Streptococcus pyogenes MGAS2096 phage protein YP_601036.1 1403686 R 370565 CDS YP_601037.1 94992938 4066475 1404104..1405276 1 NC_008023.1 deoxyribonuclease precursor 1405276 sdaD2 4066475 sdaD2 Streptococcus pyogenes MGAS2096 deoxyribonuclease precursor YP_601037.1 1404104 D 370565 CDS YP_601038.1 94992939 4066476 complement(1405392..1406588) 1 NC_008023.1 phage-associated cell wall hydrolase 1406588 4066476 MGAS2096_Spy1442 Streptococcus pyogenes MGAS2096 phage-associated cell wall hydrolase YP_601038.1 1405392 R 370565 CDS YP_601039.1 94992940 4066477 complement(1406699..1406884) 1 NC_008023.1 phage protein 1406884 4066477 MGAS2096_Spy1443 Streptococcus pyogenes MGAS2096 phage protein YP_601039.1 1406699 R 370565 CDS YP_601040.1 94992941 4065077 complement(1406881..1407180) 1 NC_008023.1 phage protein 1407180 4065077 MGAS2096_Spy1444 Streptococcus pyogenes MGAS2096 phage protein YP_601040.1 1406881 R 370565 CDS YP_601041.1 94992942 4065078 complement(1407191..1407811) 1 NC_008023.1 phage protein 1407811 4065078 MGAS2096_Spy1445 Streptococcus pyogenes MGAS2096 phage protein YP_601041.1 1407191 R 370565 CDS YP_601042.1 94992943 4065079 complement(1407814..1407975) 1 NC_008023.1 phage protein 1407975 4065079 MGAS2096_Spy1446 Streptococcus pyogenes MGAS2096 phage protein YP_601042.1 1407814 R 370565 CDS YP_601043.1 94992944 4065080 complement(1407984..1409891) 1 NC_008023.1 phage infection protein 1409891 4065080 MGAS2096_Spy1447 Streptococcus pyogenes MGAS2096 phage infection protein YP_601043.1 1407984 R 370565 CDS YP_601044.1 94992945 4065081 complement(1409902..1410537) 1 NC_008023.1 phage protein 1410537 4065081 MGAS2096_Spy1448 Streptococcus pyogenes MGAS2096 phage protein YP_601044.1 1409902 R 370565 CDS YP_601045.1 94992946 4065082 complement(1410537..1411592) 1 NC_008023.1 hyaluronoglucosaminidase 1411592 4065082 MGAS2096_Spy1449 Streptococcus pyogenes MGAS2096 hyaluronoglucosaminidase YP_601045.1 1410537 R 370565 CDS YP_601046.1 94992947 4065083 complement(1411589..1413571) 1 NC_008023.1 phage endopeptidase 1413571 4065083 MGAS2096_Spy1450 Streptococcus pyogenes MGAS2096 phage endopeptidase YP_601046.1 1411589 R 370565 CDS YP_601047.1 94992948 4065084 complement(1413581..1414423) 1 NC_008023.1 phage protein 1414423 4065084 MGAS2096_Spy1451 Streptococcus pyogenes MGAS2096 phage protein YP_601047.1 1413581 R 370565 CDS YP_601048.1 94992949 4065085 complement(1414435..1418817) 1 NC_008023.1 phage protein 1418817 4065085 MGAS2096_Spy1452 Streptococcus pyogenes MGAS2096 phage protein YP_601048.1 1414435 R 370565 CDS YP_601049.1 94992950 4065086 complement(1418832..1419065) 1 NC_008023.1 phage protein 1419065 4065086 MGAS2096_Spy1453 Streptococcus pyogenes MGAS2096 phage protein YP_601049.1 1418832 R 370565 CDS YP_601050.1 94992951 4065087 complement(1419140..1419595) 1 NC_008023.1 phage protein 1419595 4065087 MGAS2096_Spy1454 Streptococcus pyogenes MGAS2096 phage protein YP_601050.1 1419140 R 370565 CDS YP_601051.1 94992952 4065088 complement(1419649..1420248) 1 NC_008023.1 phage protein 1420248 4065088 MGAS2096_Spy1455 Streptococcus pyogenes MGAS2096 phage protein YP_601051.1 1419649 R 370565 CDS YP_601052.1 94992953 4065089 complement(1420260..1420619) 1 NC_008023.1 phage protein 1420619 4065089 MGAS2096_Spy1456 Streptococcus pyogenes MGAS2096 phage protein YP_601052.1 1420260 R 370565 CDS YP_601053.1 94992954 4065090 complement(1420623..1420967) 1 NC_008023.1 phage protein 1420967 4065090 MGAS2096_Spy1457 Streptococcus pyogenes MGAS2096 phage protein YP_601053.1 1420623 R 370565 CDS YP_601054.1 94992955 4065091 complement(1420964..1421242) 1 NC_008023.1 phage protein 1421242 4065091 MGAS2096_Spy1458 Streptococcus pyogenes MGAS2096 phage protein YP_601054.1 1420964 R 370565 CDS YP_601055.1 94992956 4065092 complement(1421253..1421609) 1 NC_008023.1 phage protein 1421609 4065092 MGAS2096_Spy1459 Streptococcus pyogenes MGAS2096 phage protein YP_601055.1 1421253 R 370565 CDS YP_601056.1 94992957 4065093 complement(1421621..1422508) 1 NC_008023.1 phage protein 1422508 4065093 MGAS2096_Spy1460 Streptococcus pyogenes MGAS2096 phage protein YP_601056.1 1421621 R 370565 CDS YP_601057.1 94992958 4065094 complement(1422521..1423090) 1 NC_008023.1 phage scaffold protein 1423090 4065094 MGAS2096_Spy1461 Streptococcus pyogenes MGAS2096 phage scaffold protein YP_601057.1 1422521 R 370565 CDS YP_601058.1 94992959 4065095 complement(1423246..1423512) 1 NC_008023.1 phage protein 1423512 4065095 MGAS2096_Spy1462 Streptococcus pyogenes MGAS2096 phage protein YP_601058.1 1423246 R 370565 CDS YP_601059.1 94992960 4065096 complement(1423515..1423703) 1 NC_008023.1 phage protein 1423703 4065096 MGAS2096_Spy1463 Streptococcus pyogenes MGAS2096 phage protein YP_601059.1 1423515 R 370565 CDS YP_601060.1 94992961 4065381 complement(1423734..1425182) 1 NC_008023.1 phage protein 1425182 4065381 MGAS2096_Spy1464 Streptococcus pyogenes MGAS2096 phage protein YP_601060.1 1423734 R 370565 CDS YP_601061.1 94992962 4065382 complement(1425139..1426671) 1 NC_008023.1 portal protein 1426671 4065382 MGAS2096_Spy1465 Streptococcus pyogenes MGAS2096 portal protein YP_601061.1 1425139 R 370565 CDS YP_601062.1 94992963 4065383 complement(1426687..1427973) 1 NC_008023.1 terminase large subunit 1427973 4065383 MGAS2096_Spy1466 Streptococcus pyogenes MGAS2096 terminase large subunit YP_601062.1 1426687 R 370565 CDS YP_601063.1 94992964 4065384 complement(1427954..1428448) 1 NC_008023.1 phage terminase small subunit 1428448 4065384 MGAS2096_Spy1467 Streptococcus pyogenes MGAS2096 phage terminase small subunit YP_601063.1 1427954 R 370565 CDS YP_601064.1 94992965 4065385 complement(1428496..1428912) 1 NC_008023.1 phage transcriptional activator 1428912 4065385 MGAS2096_Spy1468 Streptococcus pyogenes MGAS2096 phage transcriptional activator YP_601064.1 1428496 R 370565 CDS YP_601065.1 94992966 4065386 complement(1428909..1429100) 1 NC_008023.1 phage protein 1429100 4065386 MGAS2096_Spy1469 Streptococcus pyogenes MGAS2096 phage protein YP_601065.1 1428909 R 370565 CDS YP_601066.1 94992967 4065387 complement(1429090..1429941) 1 NC_008023.1 adenine-specific methyltransferase 1429941 4065387 MGAS2096_Spy1470 Streptococcus pyogenes MGAS2096 adenine-specific methyltransferase YP_601066.1 1429090 R 370565 CDS YP_601067.1 94992968 4065388 complement(1429950..1430216) 1 NC_008023.1 phage protein 1430216 4065388 MGAS2096_Spy1471 Streptococcus pyogenes MGAS2096 phage protein YP_601067.1 1429950 R 370565 CDS YP_601068.1 94992969 4065389 complement(1430213..1430380) 1 NC_008023.1 phage protein 1430380 4065389 MGAS2096_Spy1472 Streptococcus pyogenes MGAS2096 phage protein YP_601068.1 1430213 R 370565 CDS YP_601069.1 94992970 4065390 complement(1430381..1431703) 1 NC_008023.1 phage-related DNA helicase 1431703 4065390 MGAS2096_Spy1473 Streptococcus pyogenes MGAS2096 phage-related DNA helicase YP_601069.1 1430381 R 370565 CDS YP_601070.1 94992971 4065391 complement(1431700..1431993) 1 NC_008023.1 hypothetical protein 1431993 4065391 MGAS2096_Spy1474 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601070.1 1431700 R 370565 CDS YP_601071.1 94992972 4065392 complement(1432362..1434746) 1 NC_008023.1 DNA primase 1434746 4065392 MGAS2096_Spy1475 Streptococcus pyogenes MGAS2096 DNA primase YP_601071.1 1432362 R 370565 CDS YP_601072.1 94992973 4065393 complement(1434751..1436673) 1 NC_008023.1 phage-related DNA polymerase 1436673 4065393 MGAS2096_Spy1476 Streptococcus pyogenes MGAS2096 phage-related DNA polymerase YP_601072.1 1434751 R 370565 CDS YP_601073.1 94992974 4065394 complement(1436716..1437273) 1 NC_008023.1 phage protein 1437273 4065394 MGAS2096_Spy1477 Streptococcus pyogenes MGAS2096 phage protein YP_601073.1 1436716 R 370565 CDS YP_601074.1 94992975 4065395 complement(1437284..1437682) 1 NC_008023.1 phage protein 1437682 4065395 MGAS2096_Spy1478 Streptococcus pyogenes MGAS2096 phage protein YP_601074.1 1437284 R 370565 CDS YP_601075.1 94992976 4065396 complement(1437686..1438840) 1 NC_008023.1 phage protein 1438840 4065396 MGAS2096_Spy1479 Streptococcus pyogenes MGAS2096 phage protein YP_601075.1 1437686 R 370565 CDS YP_601076.1 94992977 4065397 complement(1438840..1439139) 1 NC_008023.1 phage protein 1439139 4065397 MGAS2096_Spy1480 Streptococcus pyogenes MGAS2096 phage protein YP_601076.1 1438840 R 370565 CDS YP_601077.1 94992978 4065398 complement(1439227..1439430) 1 NC_008023.1 phage protein 1439430 4065398 MGAS2096_Spy1481 Streptococcus pyogenes MGAS2096 phage protein YP_601077.1 1439227 R 370565 CDS YP_601078.1 94992979 4065399 complement(1439577..1439963) 1 NC_008023.1 phage protein 1439963 4065399 MGAS2096_Spy1482 Streptococcus pyogenes MGAS2096 phage protein YP_601078.1 1439577 R 370565 CDS YP_601079.1 94992980 4064596 complement(1439960..1440175) 1 NC_008023.1 phage protein 1440175 4064596 MGAS2096_Spy1483 Streptococcus pyogenes MGAS2096 phage protein YP_601079.1 1439960 R 370565 CDS YP_601080.1 94992981 4064597 complement(1440156..1440353) 1 NC_008023.1 phage protein 1440353 4064597 MGAS2096_Spy1484 Streptococcus pyogenes MGAS2096 phage protein YP_601080.1 1440156 R 370565 CDS YP_601081.1 94992982 4064598 complement(1440323..1440598) 1 NC_008023.1 phage protein 1440598 4064598 MGAS2096_Spy1485 Streptococcus pyogenes MGAS2096 phage protein YP_601081.1 1440323 R 370565 CDS YP_601082.1 94992983 4064599 complement(1440660..1440875) 1 NC_008023.1 phage protein 1440875 4064599 MGAS2096_Spy1486 Streptococcus pyogenes MGAS2096 phage protein YP_601082.1 1440660 R 370565 CDS YP_601083.1 94992984 4064600 1440908..1441336 1 NC_008023.1 phage protein 1441336 4064600 MGAS2096_Spy1487 Streptococcus pyogenes MGAS2096 phage protein YP_601083.1 1440908 D 370565 CDS YP_601084.1 94992985 4064601 complement(1441317..1441472) 1 NC_008023.1 phage protein 1441472 4064601 MGAS2096_Spy1488 Streptococcus pyogenes MGAS2096 phage protein YP_601084.1 1441317 R 370565 CDS YP_601085.1 94992986 4064602 1441747..1442148 1 NC_008023.1 Cro/CI family phage transcriptional regulator 1442148 4064602 MGAS2096_Spy1489 Streptococcus pyogenes MGAS2096 Cro/CI family phage transcriptional regulator YP_601085.1 1441747 D 370565 CDS YP_601086.1 94992987 4064603 1442162..1442545 1 NC_008023.1 phage protein 1442545 4064603 MGAS2096_Spy1490 Streptococcus pyogenes MGAS2096 phage protein YP_601086.1 1442162 D 370565 CDS YP_601087.1 94992988 4064604 1442556..1443107 1 NC_008023.1 phage protein 1443107 4064604 MGAS2096_Spy1491 Streptococcus pyogenes MGAS2096 phage protein YP_601087.1 1442556 D 370565 CDS YP_601088.1 94992989 4064605 1443215..1444303 1 NC_008023.1 DNA integration/recombination/inversion protein 1444303 int3 4064605 int3 Streptococcus pyogenes MGAS2096 DNA integration/recombination/inversion protein YP_601088.1 1443215 D 370565 CDS YP_601089.1 94992990 4064607 complement(1444501..1445136) 1 NC_008023.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 1445136 trmB 4064607 trmB Streptococcus pyogenes MGAS2096 tRNA (guanine-N(7)-)-methyltransferase YP_601089.1 1444501 R 370565 CDS YP_601090.1 94992991 4064608 complement(1445136..1445927) 1 NC_008023.1 phosphotransferase family protein 1445927 4064608 MGAS2096_Spy1494 Streptococcus pyogenes MGAS2096 phosphotransferase family protein YP_601090.1 1445136 R 370565 CDS YP_601091.1 94992992 4064609 complement(1445991..1447025) 1 NC_008023.1 protein ecsB 1447025 4064609 MGAS2096_Spy1495 Streptococcus pyogenes MGAS2096 protein ecsB YP_601091.1 1445991 R 370565 CDS YP_601092.1 94992993 4064610 complement(1447028..1447753) 1 NC_008023.1 ABC-type transporter ATP-binding protein ecsA 1447753 4064610 MGAS2096_Spy1496 Streptococcus pyogenes MGAS2096 ABC-type transporter ATP-binding protein ecsA YP_601092.1 1447028 R 370565 CDS YP_601093.1 94992994 4064611 1447825..1448244 1 NC_008023.1 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) 1448244 hit 4064611 hit Streptococcus pyogenes MGAS2096 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) YP_601093.1 1447825 D 370565 CDS YP_601094.1 94992995 4064612 1448241..1448597 1 NC_008023.1 hypothetical protein 1448597 4064612 MGAS2096_Spy1498 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601094.1 1448241 D 370565 CDS YP_601095.1 94992996 4064613 complement(1448708..1449988) 1 NC_008023.1 LytR family transcriptional regulator 1449988 lytR 4064613 lytR Streptococcus pyogenes MGAS2096 LytR family transcriptional regulator YP_601095.1 1448708 R 370565 CDS YP_601096.1 94992997 4064614 complement(1449997..1450521) 1 NC_008023.1 acetyltransferase 1450521 4064614 MGAS2096_Spy1500 Streptococcus pyogenes MGAS2096 acetyltransferase YP_601096.1 1449997 R 370565 CDS YP_601097.1 94992998 4065420 complement(1450496..1450957) 1 NC_008023.1 ATP/GTP hydrolase 1450957 4065420 MGAS2096_Spy1501 Streptococcus pyogenes MGAS2096 ATP/GTP hydrolase YP_601097.1 1450496 R 370565 CDS YP_601098.1 94992999 4065421 complement(1451111..1452571) 1 NC_008023.1 guanine-hypoxanthine permease 1452571 4065421 MGAS2096_Spy1502 Streptococcus pyogenes MGAS2096 guanine-hypoxanthine permease YP_601098.1 1451111 R 370565 CDS YP_601099.1 94993000 4065422 1452835..1453134 1 NC_008023.1 HAD superfamily; hydrolase 1453134 4065422 MGAS2096_Spy1503 Streptococcus pyogenes MGAS2096 hydrolase YP_601099.1 1452835 D 370565 CDS YP_601100.1 94993001 4065423 1453142..1453648 1 NC_008023.1 HAD superfamily; hydrolase 1453648 4065423 MGAS2096_Spy1504 Streptococcus pyogenes MGAS2096 hydrolase YP_601100.1 1453142 D 370565 CDS YP_601101.1 94993002 4065424 1454000..1454605 1 NC_008023.1 PTS system mannose-specific transporter subunit IIAB 1454605 manL 4065424 manL Streptococcus pyogenes MGAS2096 PTS system mannose-specific transporter subunit IIAB YP_601101.1 1454000 D 370565 CDS YP_601102.1 94993003 4065425 1454637..1454993 1 NC_008023.1 PTS system mannose-specific transporter subunit IIAB 1454993 4065425 MGAS2096_Spy1506 Streptococcus pyogenes MGAS2096 PTS system mannose-specific transporter subunit IIAB YP_601102.1 1454637 D 370565 CDS YP_601103.1 94993004 4065426 1455082..1455891 1 NC_008023.1 PTS system mannose-specific transporter subunit IIC 1455891 manM 4065426 manM Streptococcus pyogenes MGAS2096 PTS system mannose-specific transporter subunit IIC YP_601103.1 1455082 D 370565 CDS YP_601104.1 94993005 4065427 1455908..1456819 1 NC_008023.1 PTS system mannose-specific transporter subunit IID 1456819 manN 4065427 manN Streptococcus pyogenes MGAS2096 PTS system mannose-specific transporter subunit IID YP_601104.1 1455908 D 370565 CDS YP_601105.1 94993006 4065428 1456840..1457292 1 NC_008023.1 putative cytoplasmic protein 1457292 manO 4065428 manO Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_601105.1 1456840 D 370565 CDS YP_601106.1 94993007 4065429 1457683..1458960 1 NC_008023.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1458960 serS 4065429 serS Streptococcus pyogenes MGAS2096 seryl-tRNA synthetase YP_601106.1 1457683 D 370565 CDS YP_601107.1 94993008 4065430 complement(1459182..1459952) 1 NC_008023.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; these proteins present a shorter N-terminus; acetyl-CoA carboxylase subunit alpha 1459952 accD 4065430 accD Streptococcus pyogenes MGAS2096 acetyl-CoA carboxylase subunit alpha YP_601107.1 1459182 R 370565 CDS YP_601108.1 94993009 4065431 complement(1459949..1460815) 1 NC_008023.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 1460815 accA 4065431 accA Streptococcus pyogenes MGAS2096 acetyl-CoA carboxylase subunit beta YP_601108.1 1459949 R 370565 CDS YP_601109.2 162139126 4065432 complement(1460824..1462188) 1 NC_008023.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 1462188 accC 4065432 accC Streptococcus pyogenes MGAS2096 acetyl-CoA carboxylase biotin carboxylase subunit YP_601109.2 1460824 R 370565 CDS YP_601110.1 94993011 4065433 complement(1462220..1462642) 1 NC_008023.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 1462642 fabZ 4065433 fabZ Streptococcus pyogenes MGAS2096 (3R)-hydroxymyristoyl-ACP dehydratase YP_601110.1 1462220 R 370565 CDS YP_601111.1 94993012 4065434 complement(1462639..1462803) 1 NC_008023.1 biotin carboxyl carrier protein of acetyl-CoA carboxylase 1462803 accB 4065434 accB Streptococcus pyogenes MGAS2096 biotin carboxyl carrier protein of acetyl-CoA carboxylase YP_601111.1 1462639 R 370565 CDS YP_601112.1 94993013 4065435 complement(1462922..1463137) 1 NC_008023.1 biotin carboxyl carrier protein of acetyl-CoA carboxylase 1463137 4065435 MGAS2096_Spy1516 Streptococcus pyogenes MGAS2096 biotin carboxyl carrier protein of acetyl-CoA carboxylase YP_601112.1 1462922 R 370565 CDS YP_601113.1 94993014 4065436 complement(1463139..1464371) 1 NC_008023.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 1464371 fabF 4065436 fabF Streptococcus pyogenes MGAS2096 3-oxoacyl-(acyl carrier protein) synthase II YP_601113.1 1463139 R 370565 CDS YP_601114.1 94993015 4065437 complement(1464386..1465120) 1 NC_008023.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1465120 fabG 4065437 fabG Streptococcus pyogenes MGAS2096 3-ketoacyl-ACP reductase YP_601114.1 1464386 R 370565 CDS YP_601115.1 94993016 4065438 complement(1465110..1466054) 1 NC_008023.1 acyl-carrier-protein S-malonyltransferase 1466054 fabD 4065438 fabD Streptococcus pyogenes MGAS2096 acyl-carrier-protein S-malonyltransferase YP_601115.1 1465110 R 370565 CDS YP_601116.1 94993017 4065575 complement(1466073..1467044) 1 NC_008023.1 acyl-carrier protein; enoyl- reductase (NADH) 1467044 fabK 4065575 fabK Streptococcus pyogenes MGAS2096 enoyl- reductase (NADH) YP_601116.1 1466073 R 370565 CDS YP_601117.1 94993018 4065576 complement(1467246..1467470) 1 NC_008023.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1467470 acpP 4065576 acpP Streptococcus pyogenes MGAS2096 acyl carrier protein YP_601117.1 1467246 R 370565 CDS YP_601118.1 94993019 4065577 complement(1467531..1468505) 1 NC_008023.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 1468505 fabH 4065577 fabH Streptococcus pyogenes MGAS2096 3-oxoacyl-ACP synthase YP_601118.1 1467531 R 370565 CDS YP_601119.1 94993020 4065578 complement(1468506..1468976) 1 NC_008023.1 MarR family transcriptional regulator 1468976 4065578 MGAS2096_Spy1523 Streptococcus pyogenes MGAS2096 MarR family transcriptional regulator YP_601119.1 1468506 R 370565 CDS YP_601120.1 94993021 4065579 complement(1469014..1469805) 1 NC_008023.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1469805 phaB 4065579 phaB Streptococcus pyogenes MGAS2096 enoyl-CoA hydratase YP_601120.1 1469014 R 370565 CDS YP_601121.1 94993022 4065580 complement(1470027..1471217) 1 NC_008023.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 1471217 dnaJ 4065580 dnaJ Streptococcus pyogenes MGAS2096 chaperone protein DnaJ YP_601121.1 1470027 R 370565 CDS YP_601122.1 94993023 4065581 complement(1471444..1473270) 1 NC_008023.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 1473270 dnaK 4065581 dnaK Streptococcus pyogenes MGAS2096 molecular chaperone DnaK YP_601122.1 1471444 R 370565 CDS YP_601123.1 94993024 4065582 complement(1473451..1474023) 1 NC_008023.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 1474023 grpE 4065582 grpE Streptococcus pyogenes MGAS2096 heat shock protein GrpE YP_601123.1 1473451 R 370565 CDS YP_601124.1 94993025 4065583 complement(1474026..1475060) 1 NC_008023.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 1475060 hrcA 4065583 hrcA Streptococcus pyogenes MGAS2096 heat-inducible transcription repressor YP_601124.1 1474026 R 370565 CDS YP_601125.1 94993026 4065584 complement(1475195..1475764) 1 NC_008023.1 N-acetylmuramoyl-L-alanine amidase 1475764 4065584 MGAS2096_Spy1529 Streptococcus pyogenes MGAS2096 N-acetylmuramoyl-L-alanine amidase YP_601125.1 1475195 R 370565 CDS YP_601126.1 94993027 4065585 complement(1475761..1476504) 1 NC_008023.1 D-alanyl-D-alanine metallocarboxypeptidase 1476504 4065585 MGAS2096_Spy1530 Streptococcus pyogenes MGAS2096 D-alanyl-D-alanine metallocarboxypeptidase YP_601126.1 1475761 R 370565 CDS YP_601127.1 94993028 4065586 complement(1476494..1477201) 1 NC_008023.1 phosphoglycerate mutase family protein 1477201 4065586 MGAS2096_Spy1531 Streptococcus pyogenes MGAS2096 phosphoglycerate mutase family protein YP_601127.1 1476494 R 370565 CDS YP_601128.1 94993029 4065587 complement(1477593..1477841) 1 NC_008023.1 hypothetical protein 1477841 4065587 MGAS2096_Spy1532 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601128.1 1477593 R 370565 CDS YP_601129.1 94993030 4065588 complement(1478051..1478266) 1 NC_008023.1 hypothetical protein 1478266 4065588 MGAS2096_Spy1533 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601129.1 1478051 R 370565 CDS YP_601130.1 94993031 4065589 complement(1478263..1479702) 1 NC_008023.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 1479702 gatB 4065589 gatB Streptococcus pyogenes MGAS2096 aspartyl/glutamyl-tRNA amidotransferase subunit B YP_601130.1 1478263 R 370565 CDS YP_601131.1 94993032 4065590 complement(1479702..1481168) 1 NC_008023.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 1481168 gatA 4065590 gatA Streptococcus pyogenes MGAS2096 aspartyl/glutamyl-tRNA amidotransferase subunit A YP_601131.1 1479702 R 370565 CDS YP_601132.2 162139125 4065591 complement(1481168..1481470) 1 NC_008023.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 1481470 gatC 4065591 gatC Streptococcus pyogenes MGAS2096 aspartyl/glutamyl-tRNA amidotransferase subunit C YP_601132.2 1481168 R 370565 CDS YP_601133.1 94993034 4065592 complement(1481703..1481951) 1 NC_008023.1 pyruvate,phosphate dikinase 1481951 4065592 MGAS2096_Spy1537 Streptococcus pyogenes MGAS2096 pyruvate,phosphate dikinase YP_601133.1 1481703 R 370565 CDS YP_601134.1 94993035 4065593 complement(1482466..1483023) 1 NC_008023.1 bifunctional; pyrazinamidase / nicotinamidase 1483023 4065593 MGAS2096_Spy1538 Streptococcus pyogenes MGAS2096 pyrazinamidase / nicotinamidase YP_601134.1 1482466 R 370565 CDS YP_601135.1 94993036 4065594 complement(1483167..1484012) 1 NC_008023.1 CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; transcriptional repressor CodY 1484012 codY 4065594 codY Streptococcus pyogenes MGAS2096 transcriptional repressor CodY YP_601135.1 1483167 R 370565 CDS YP_601136.2 162139124 4065732 complement(1484167..1485381) 1 NC_008023.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 1485381 4065732 MGAS2096_Spy1540 Streptococcus pyogenes MGAS2096 aminotransferase AlaT YP_601136.2 1484167 R 370565 CDS YP_601137.1 94993038 4065733 1485522..1486064 1 NC_008023.1 universal stress protein 1486064 4065733 MGAS2096_Spy1541 Streptococcus pyogenes MGAS2096 universal stress protein YP_601137.1 1485522 D 370565 CDS YP_601138.1 94993039 4065734 complement(1486187..1487575) 1 NC_008023.1 HAD superfamily; hydrolase 1487575 4065734 MGAS2096_Spy1542 Streptococcus pyogenes MGAS2096 hydrolase YP_601138.1 1486187 R 370565 CDS YP_601139.1 94993040 4065735 1487647..1488612 1 NC_008023.1 L-asparaginase 1488612 asnB 4065735 asnB Streptococcus pyogenes MGAS2096 L-asparaginase YP_601139.1 1487647 D 370565 CDS YP_601140.1 94993041 4065736 complement(1488961..1489665) 1 NC_008023.1 ABC transporter permease 1489665 4065736 MGAS2096_Spy1544 Streptococcus pyogenes MGAS2096 ABC transporter permease YP_601140.1 1488961 R 370565 CDS YP_601141.1 94993042 4065737 complement(1489678..1490580) 1 NC_008023.1 lantibiotic ABC transporter ATP-binding protein 1490580 4065737 MGAS2096_Spy1545 Streptococcus pyogenes MGAS2096 lantibiotic ABC transporter ATP-binding protein YP_601141.1 1489678 R 370565 CDS YP_601142.1 94993043 4065738 complement(1490873..1492888) 1 NC_008023.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 1492888 recG 4065738 recG Streptococcus pyogenes MGAS2096 ATP-dependent DNA helicase RecG YP_601142.1 1490873 R 370565 CDS YP_601143.1 94993044 4065739 1492981..1493181 1 NC_008023.1 hypothetical protein 1493181 4065739 MGAS2096_Spy1547 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601143.1 1492981 D 370565 CDS YP_601144.1 94993045 4065740 complement(1493263..1494717) 1 NC_008023.1 cobalt transport ATP-binding protein cbiO 1494717 4065740 MGAS2096_Spy1548 Streptococcus pyogenes MGAS2096 cobalt transport ATP-binding protein cbiO YP_601144.1 1493263 R 370565 CDS YP_601145.1 94993046 4065741 complement(1494654..1495334) 1 NC_008023.1 cobalt transport protein cbiQ 1495334 4065741 MGAS2096_Spy1549 Streptococcus pyogenes MGAS2096 cobalt transport protein cbiQ YP_601145.1 1494654 R 370565 CDS YP_601146.1 94993047 4065742 complement(1495331..1495924) 1 NC_008023.1 membrane-bound protein 1495924 4065742 MGAS2096_Spy1550 Streptococcus pyogenes MGAS2096 membrane-bound protein YP_601146.1 1495331 R 370565 CDS YP_601147.1 94993048 4065743 complement(1495921..1497624) 1 NC_008023.1 ABC transporter ATP-binding protein 1497624 4065743 MGAS2096_Spy1551 Streptococcus pyogenes MGAS2096 ABC transporter ATP-binding protein YP_601147.1 1495921 R 370565 CDS YP_601148.1 94993049 4065744 complement(1497584..1499347) 1 NC_008023.1 ABC transporter ATP-binding protein 1499347 4065744 MGAS2096_Spy1552 Streptococcus pyogenes MGAS2096 ABC transporter ATP-binding protein YP_601148.1 1497584 R 370565 CDS YP_601149.1 94993050 4065745 complement(1499344..1500180) 1 NC_008023.1 ferrichrome ABC transporter ATP-binding protein 1500180 fhuC 4065745 fhuC Streptococcus pyogenes MGAS2096 ferrichrome ABC transporter ATP-binding protein YP_601149.1 1499344 R 370565 CDS YP_601150.1 94993051 4065746 complement(1500177..1501226) 1 NC_008023.1 ferrichrome transport system permease fhuB 1501226 4065746 MGAS2096_Spy1554 Streptococcus pyogenes MGAS2096 ferrichrome transport system permease fhuB YP_601150.1 1500177 R 370565 CDS YP_601151.1 94993052 4065747 complement(1501201..1502112) 1 NC_008023.1 ferrichrome-binding protein 1502112 4065747 MGAS2096_Spy1555 Streptococcus pyogenes MGAS2096 ferrichrome-binding protein YP_601151.1 1501201 R 370565 CDS YP_601152.1 94993053 4065748 complement(1502082..1502945) 1 NC_008023.1 hypothetical protein 1502945 shp 4065748 shp Streptococcus pyogenes MGAS2096 hypothetical protein YP_601152.1 1502082 R 370565 CDS YP_601153.1 94993054 4065749 complement(1503142..1506975) 1 NC_008023.1 iron ABC transporter permease 1506975 4065749 MGAS2096_Spy1557 Streptococcus pyogenes MGAS2096 iron ABC transporter permease YP_601153.1 1503142 R 370565 CDS YP_601154.1 94993055 4065750 complement(1507459..1508988) 1 NC_008023.1 immunogenic secreted protein 1508988 isp2 4065750 isp2 Streptococcus pyogenes MGAS2096 immunogenic secreted protein YP_601154.1 1507459 R 370565 CDS YP_601155.1 94993056 4065361 complement(1509075..1510175) 1 NC_008023.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 1510175 alr 4065361 alr Streptococcus pyogenes MGAS2096 alanine racemase YP_601155.1 1509075 R 370565 CDS YP_601156.1 94993057 4065362 complement(1510172..1510528) 1 NC_008023.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 1510528 acpS 4065362 acpS Streptococcus pyogenes MGAS2096 4'-phosphopantetheinyl transferase YP_601156.1 1510172 R 370565 CDS YP_601157.1 94993058 4065363 complement(1510644..1513163) 1 NC_008023.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 1513163 secA 4065363 secA Streptococcus pyogenes MGAS2096 preprotein translocase subunit SecA YP_601157.1 1510644 R 370565 CDS YP_601158.1 94993059 4065364 complement(1513328..1514470) 1 NC_008023.1 transposase 1514470 4065364 MGAS2096_Spy1562 Streptococcus pyogenes MGAS2096 transposase YP_601158.1 1513328 R 370565 CDS YP_601159.1 94993060 4065365 complement(1514622..1515575) 1 NC_008023.1 mannose-6-phosphate isomerase 1515575 pmi 4065365 pmi Streptococcus pyogenes MGAS2096 mannose-6-phosphate isomerase YP_601159.1 1514622 R 370565 CDS YP_601160.1 94993061 4065366 complement(1515670..1516554) 1 NC_008023.1 fructokinase 1516554 scrK 4065366 scrK Streptococcus pyogenes MGAS2096 fructokinase YP_601160.1 1515670 R 370565 CDS YP_601161.1 94993062 4065367 complement(1516818..1519859) 1 NC_008023.1 endo-beta-N-acetylglucosaminidase F2 1519859 endoS 4065367 endoS Streptococcus pyogenes MGAS2096 endo-beta-N-acetylglucosaminidase F2 YP_601161.1 1516818 R 370565 CDS YP_601162.1 94993063 4065368 complement(1519829..1519993) 1 NC_008023.1 hypothetical protein 1519993 4065368 MGAS2096_Spy1566 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601162.1 1519829 R 370565 CDS YP_601163.1 94993064 4065369 complement(1520036..1521733) 1 NC_008023.1 PTS system sucrose-specific transporter subunit IIABC 1521733 scrA 4065369 scrA Streptococcus pyogenes MGAS2096 PTS system sucrose-specific transporter subunit IIABC YP_601163.1 1520036 R 370565 CDS YP_601164.1 94993065 4065370 1522386..1523600 1 NC_008023.1 sucrose-6-phosphate hydrolase 1523600 scrB 4065370 scrB Streptococcus pyogenes MGAS2096 sucrose-6-phosphate hydrolase YP_601164.1 1522386 D 370565 CDS YP_601165.1 94993066 4065371 1523605..1524570 1 NC_008023.1 sucrose operon repressor 1524570 scrR 4065371 scrR Streptococcus pyogenes MGAS2096 sucrose operon repressor YP_601165.1 1523605 D 370565 CDS YP_601166.1 94993067 4065372 complement(1524711..1525181) 1 NC_008023.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 1525181 nusB 4065372 nusB Streptococcus pyogenes MGAS2096 transcription antitermination protein NusB YP_601166.1 1524711 R 370565 CDS YP_601167.1 94993068 4065373 complement(1525156..1525545) 1 NC_008023.1 Gls24 family general stress protein 1525545 4065373 MGAS2096_Spy1571 Streptococcus pyogenes MGAS2096 Gls24 family general stress protein YP_601167.1 1525156 R 370565 CDS YP_601168.1 94993069 4065374 complement(1525591..1526148) 1 NC_008023.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 1526148 efp 4065374 efp Streptococcus pyogenes MGAS2096 elongation factor P YP_601168.1 1525591 R 370565 CDS YP_601169.1 94993070 4065375 complement(1526244..1526750) 1 NC_008023.1 ComE operon protein 2 1526750 comEB 4065375 comEB Streptococcus pyogenes MGAS2096 ComE operon protein 2 YP_601169.1 1526244 R 370565 CDS YP_601170.1 94993071 4065376 complement(1526740..1527711) 1 NC_008023.1 Xaa-Pro dipeptidase 1527711 4065376 MGAS2096_Spy1574 Streptococcus pyogenes MGAS2096 Xaa-Pro dipeptidase YP_601170.1 1526740 R 370565 CDS YP_601171.1 94993072 4065377 complement(1527930..1530788) 1 NC_008023.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 1530788 uvrA 4065377 uvrA Streptococcus pyogenes MGAS2096 excinuclease ABC subunit A YP_601171.1 1527930 R 370565 CDS YP_601172.1 94993073 4065378 1530961..1531905 1 NC_008023.1 magnesium/cobalt transporter CorA 1531905 corA 4065378 corA Streptococcus pyogenes MGAS2096 magnesium/cobalt transporter CorA YP_601172.1 1530961 D 370565 CDS YP_601173.1 94993074 4065379 1532037..1532693 1 NC_008023.1 hypothetical protein 1532693 4065379 MGAS2096_Spy1577 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601173.1 1532037 D 370565 CDS YP_601174.1 94993075 4065380 complement(1532826..1533065) 1 NC_008023.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 1533065 rpsR 4065380 rpsR Streptococcus pyogenes MGAS2096 30S ribosomal protein S18 YP_601174.1 1532826 R 370565 CDS YP_601175.1 94993076 4064694 complement(1533230..1533721) 1 NC_008023.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 1533721 ssb2 4064694 ssb2 Streptococcus pyogenes MGAS2096 single-stranded DNA-binding protein YP_601175.1 1533230 R 370565 CDS YP_601176.1 94993077 4064695 complement(1533743..1534033) 1 NC_008023.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 1534033 rpsF 4064695 rpsF Streptococcus pyogenes MGAS2096 30S ribosomal protein S6 YP_601176.1 1533743 R 370565 CDS YP_601177.1 94993078 4064696 complement(1534206..1534499) 1 NC_008023.1 hypothetical protein 1534499 4064696 MGAS2096_Spy1581 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601177.1 1534206 R 370565 CDS YP_601178.1 94993079 4064697 1534898..1535821 1 NC_008023.1 A/G-specific adenine glycosylase 1535821 mutY 4064697 mutY Streptococcus pyogenes MGAS2096 A/G-specific adenine glycosylase YP_601178.1 1534898 D 370565 CDS YP_601179.1 94993080 4064698 1535888..1536484 1 NC_008023.1 transcriptional regulator 1536484 4064698 MGAS2096_Spy1583 Streptococcus pyogenes MGAS2096 transcriptional regulator YP_601179.1 1535888 D 370565 CDS YP_601180.1 94993081 4064699 complement(1536536..1536892) 1 NC_008023.1 thioredoxin 1536892 trx 4064699 trx Streptococcus pyogenes MGAS2096 thioredoxin YP_601180.1 1536536 R 370565 CDS YP_601181.1 94993082 4064700 complement(1536931..1537431) 1 NC_008023.1 phosphatidylglycerophosphatase B 1537431 4064700 MGAS2096_Spy1585 Streptococcus pyogenes MGAS2096 phosphatidylglycerophosphatase B YP_601181.1 1536931 R 370565 CDS YP_601182.1 94993083 4064701 complement(1537435..1539891) 1 NC_008023.1 DNA mismatch repair protein mutS 1539891 mutS2 4064701 mutS2 Streptococcus pyogenes MGAS2096 DNA mismatch repair protein mutS YP_601182.1 1537435 R 370565 CDS YP_601183.1 94993084 4064702 complement(1539923..1540468) 1 NC_008023.1 CvpA family membrane protein 1540468 4064702 MGAS2096_Spy1587 Streptococcus pyogenes MGAS2096 CvpA family membrane protein YP_601183.1 1539923 R 370565 CDS YP_601184.1 94993085 4064703 complement(1540471..1540779) 1 NC_008023.1 putative cytoplasmic protein 1540779 4064703 MGAS2096_Spy1588 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_601184.1 1540471 R 370565 CDS YP_601185.1 94993086 4064704 1540936..1541838 1 NC_008023.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease HIII 1541838 4064704 MGAS2096_Spy1589 Streptococcus pyogenes MGAS2096 ribonuclease HIII YP_601185.1 1540936 D 370565 CDS YP_601186.1 94993087 4064705 1541783..1542442 1 NC_008023.1 Signal peptidase I 1542442 spi 4064705 spi Streptococcus pyogenes MGAS2096 Signal peptidase I YP_601186.1 1541783 D 370565 CDS YP_601187.1 94993088 4064706 1542500..1544953 1 NC_008023.1 exodeoxyribonuclease V subunit alpha 1544953 recD 4064706 recD Streptococcus pyogenes MGAS2096 exodeoxyribonuclease V subunit alpha YP_601187.1 1542500 D 370565 CDS YP_601188.1 94993089 4064707 1545044..1545535 1 NC_008023.1 hypothetical protein 1545535 4064707 MGAS2096_Spy1592 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601188.1 1545044 D 370565 CDS YP_601189.1 94993090 4064708 complement(1545620..1546714) 1 NC_008023.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 1546714 dinP 4064708 dinP Streptococcus pyogenes MGAS2096 DNA polymerase IV YP_601189.1 1545620 R 370565 CDS YP_601190.1 94993091 4064709 1546896..1549250 1 NC_008023.1 formate acetyltransferase 1549250 pfl 4064709 pfl Streptococcus pyogenes MGAS2096 formate acetyltransferase YP_601190.1 1546896 D 370565 CDS YP_601191.1 94993092 4064710 complement(1549430..1550380) 1 NC_008023.1 Beta-lactamase family protein 1550380 4064710 MGAS2096_Spy1595 Streptococcus pyogenes MGAS2096 Beta-lactamase family protein YP_601191.1 1549430 R 370565 CDS YP_601192.1 94993093 4064711 complement(1550365..1551117) 1 NC_008023.1 putative cytoplasmic protein 1551117 4064711 MGAS2096_Spy1596 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_601192.1 1550365 R 370565 CDS YP_601193.1 94993094 4064712 1551379..1552311 1 NC_008023.1 hypothetical protein 1552311 4064712 MGAS2096_Spy1597 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601193.1 1551379 D 370565 CDS YP_601194.1 94993095 4065964 complement(1552647..1553594) 1 NC_008023.1 Aquaporin / glycerol uptake facilitator protein 1553594 glpF2 4065964 glpF2 Streptococcus pyogenes MGAS2096 Aquaporin / glycerol uptake facilitator protein YP_601194.1 1552647 R 370565 CDS YP_601195.1 94993096 4065965 complement(1553665..1553811) 1 NC_008023.1 universal stress protein 1553811 4065965 MGAS2096_Spy1599 Streptococcus pyogenes MGAS2096 universal stress protein YP_601195.1 1553665 R 370565 CDS YP_601196.1 94993097 4065966 complement(1553997..1555298) 1 NC_008023.1 major facilitator transporter 1555298 norA 4065966 norA Streptococcus pyogenes MGAS2096 major facilitator transporter YP_601196.1 1553997 R 370565 CDS YP_601197.1 94993098 4065967 1555299..1556018 1 NC_008023.1 Crp family transcriptional regulator 1556018 srv 4065967 srv Streptococcus pyogenes MGAS2096 Crp family transcriptional regulator YP_601197.1 1555299 D 370565 CDS YP_601198.1 94993099 4065968 1556040..1558322 1 NC_008023.1 catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue; x-prolyl-dipeptidyl aminopeptidase 1558322 pepXP 4065968 pepXP Streptococcus pyogenes MGAS2096 x-prolyl-dipeptidyl aminopeptidase YP_601198.1 1556040 D 370565 CDS YP_601199.1 94993100 4065969 complement(1558402..1558623) 1 NC_008023.1 Cro/CI family transcriptional regulator 1558623 4065969 MGAS2096_Spy1603 Streptococcus pyogenes MGAS2096 Cro/CI family transcriptional regulator YP_601199.1 1558402 R 370565 CDS YP_601200.1 94993101 4065970 1558793..1559167 1 NC_008023.1 transcriptional regulator 1559167 4065970 MGAS2096_Spy1604 Streptococcus pyogenes MGAS2096 transcriptional regulator YP_601200.1 1558793 D 370565 CDS YP_601201.1 94993102 4065971 1559360..1559659 1 NC_008023.1 hypothetical protein 1559659 4065971 MGAS2096_Spy1605 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601201.1 1559360 D 370565 CDS YP_601202.1 94993103 4065972 complement(1559843..1560460) 1 NC_008023.1 MerR family transcriptional regulator 1560460 4065972 MGAS2096_Spy1606 Streptococcus pyogenes MGAS2096 MerR family transcriptional regulator YP_601202.1 1559843 R 370565 CDS YP_601203.1 94993104 4065973 complement(1560606..1561232) 1 NC_008023.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 1561232 dnaQ 4065973 dnaQ Streptococcus pyogenes MGAS2096 DNA polymerase III subunit epsilon YP_601203.1 1560606 R 370565 CDS YP_601204.1 94993105 4065974 complement(1561242..1561823) 1 NC_008023.1 putative cytoplasmic protein 1561823 4065974 MGAS2096_Spy1608 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_601204.1 1561242 R 370565 CDS YP_601205.1 94993106 4065975 1561977..1563146 1 NC_008023.1 NAD(FAD)-utilizing dehydrogenases 1563146 4065975 MGAS2096_Spy1609 Streptococcus pyogenes MGAS2096 NAD(FAD)-utilizing dehydrogenases YP_601205.1 1561977 D 370565 CDS YP_601206.1 94993107 4065976 complement(1563241..1563912) 1 NC_008023.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 1563912 deoC 4065976 deoC Streptococcus pyogenes MGAS2096 deoxyribose-phosphate aldolase YP_601206.1 1563241 R 370565 CDS YP_601207.1 94993108 4065977 complement(1563942..1565156) 1 NC_008023.1 nucleoside permease nupC 1565156 nupC 4065977 nupC Streptococcus pyogenes MGAS2096 nucleoside permease nupC YP_601207.1 1563942 R 370565 CDS YP_601208.1 94993109 4065978 complement(1565165..1565944) 1 NC_008023.1 uridine phosphorylase 1565944 udp 4065978 udp Streptococcus pyogenes MGAS2096 uridine phosphorylase YP_601208.1 1565165 R 370565 CDS YP_601209.1 94993110 4065979 complement(1566009..1566110) 1 NC_008023.1 hypothetical protein 1566110 4065979 MGAS2096_Spy1613 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601209.1 1566009 R 370565 CDS YP_601210.1 94993111 4065980 1566184..1566942 1 NC_008023.1 GntR family transcriptional regulator 1566942 crgR 4065980 crgR Streptococcus pyogenes MGAS2096 GntR family transcriptional regulator YP_601210.1 1566184 D 370565 CDS YP_601211.1 94993112 4065981 1567162..1567431 1 NC_008023.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 1567431 rpsN 4065981 rpsN Streptococcus pyogenes MGAS2096 30S ribosomal protein S14 YP_601211.1 1567162 D 370565 CDS YP_601212.1 94993113 4065982 complement(1567602..1567916) 1 NC_008023.1 O-sialoglycoprotein endopeptidase 1567916 4065982 MGAS2096_Spy1616 Streptococcus pyogenes MGAS2096 O-sialoglycoprotein endopeptidase YP_601212.1 1567602 R 370565 CDS YP_601213.1 94993114 4065983 complement(1567829..1568629) 1 NC_008023.1 O-sialoglycoprotein endopeptidase 1568629 4065983 MGAS2096_Spy1617 Streptococcus pyogenes MGAS2096 O-sialoglycoprotein endopeptidase YP_601213.1 1567829 R 370565 CDS YP_601214.1 94993115 4066176 complement(1568619..1569074) 1 NC_008023.1 ribosomal-protein-S18-alanine acetyltransferase 1569074 4066176 MGAS2096_Spy1618 Streptococcus pyogenes MGAS2096 ribosomal-protein-S18-alanine acetyltransferase YP_601214.1 1568619 R 370565 CDS YP_601215.1 94993116 4066177 complement(1569046..1569777) 1 NC_008023.1 M22 family non-proteolytic peptidase 1569777 4066177 MGAS2096_Spy1619 Streptococcus pyogenes MGAS2096 M22 family non-proteolytic peptidase YP_601215.1 1569046 R 370565 CDS YP_601216.1 94993117 4066178 1570027..1570257 1 NC_008023.1 hypothetical protein 1570257 4066178 MGAS2096_Spy1620 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601216.1 1570027 D 370565 CDS YP_601217.1 94993118 4066179 1570259..1571941 1 NC_008023.1 Zn-dependent hydrolase 1571941 4066179 MGAS2096_Spy1621 Streptococcus pyogenes MGAS2096 Zn-dependent hydrolase YP_601217.1 1570259 D 370565 CDS YP_601218.1 94993119 4066180 complement(1572169..1573515) 1 NC_008023.1 glutamine synthetase 1573515 glnA 4066180 glnA Streptococcus pyogenes MGAS2096 glutamine synthetase YP_601218.1 1572169 R 370565 CDS YP_601219.1 94993120 4066181 complement(1573553..1573924) 1 NC_008023.1 MerR family transcriptional regulator 1573924 4066181 MGAS2096_Spy1623 Streptococcus pyogenes MGAS2096 MerR family transcriptional regulator YP_601219.1 1573553 R 370565 CDS YP_601220.1 94993121 4066182 complement(1573991..1574542) 1 NC_008023.1 hypothetical protein 1574542 4066182 MGAS2096_Spy1624 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601220.1 1573991 R 370565 CDS YP_601221.1 94993122 4066183 complement(1574805..1576001) 1 NC_008023.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 1576001 pgk 4066183 pgk Streptococcus pyogenes MGAS2096 phosphoglycerate kinase YP_601221.1 1574805 R 370565 CDS YP_601222.1 94993123 4066184 complement(1576194..1577048) 1 NC_008023.1 acid phosphatase 1577048 lppC 4066184 lppC Streptococcus pyogenes MGAS2096 acid phosphatase YP_601222.1 1576194 R 370565 CDS YP_601223.1 94993124 4066185 complement(1577277..1578167) 1 NC_008023.1 membrane protease family protein 1578167 4066185 MGAS2096_Spy1627 Streptococcus pyogenes MGAS2096 membrane protease family protein YP_601223.1 1577277 R 370565 CDS YP_601224.1 94993125 4066186 complement(1578404..1580068) 1 NC_008023.1 dihydroxyacetone kinase family protein 1580068 4066186 MGAS2096_Spy1628 Streptococcus pyogenes MGAS2096 dihydroxyacetone kinase family protein YP_601224.1 1578404 R 370565 CDS YP_601225.1 94993126 4066187 complement(1580068..1580433) 1 NC_008023.1 Gls24 family general stress protein 1580433 asp 4066187 asp Streptococcus pyogenes MGAS2096 Gls24 family general stress protein YP_601225.1 1580068 R 370565 CDS YP_601226.1 94993127 4066188 complement(1580585..1580773) 1 NC_008023.1 required for 70S ribosome assembly; 50S ribosomal protein L28 1580773 rpmB 4066188 rpmB Streptococcus pyogenes MGAS2096 50S ribosomal protein L28 YP_601226.1 1580585 R 370565 CDS YP_601227.1 94993128 4066189 complement(1581155..1582036) 1 NC_008023.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 1582036 fba 4066189 fba Streptococcus pyogenes MGAS2096 fructose-bisphosphate aldolase YP_601227.1 1581155 R 370565 CDS YP_601228.1 94993129 4066191 complement(1582382..1583308) 1 NC_008023.1 Alpha/beta hydrolase 1583308 4066191 MGAS2096_Spy1632 Streptococcus pyogenes MGAS2096 Alpha/beta hydrolase YP_601228.1 1582382 R 370565 CDS YP_601229.1 94993130 4066192 complement(1583476..1585080) 1 NC_008023.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 1585080 pyrG 4066192 pyrG Streptococcus pyogenes MGAS2096 CTP synthetase YP_601229.1 1583476 R 370565 CDS YP_601230.1 94993131 4066193 complement(1585337..1585945) 1 NC_008023.1 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; DNA-directed RNA polymerase subunit delta 1585945 rpoE 4066193 rpoE Streptococcus pyogenes MGAS2096 DNA-directed RNA polymerase subunit delta YP_601230.1 1585337 R 370565 CDS YP_601231.1 94993132 4064791 complement(1586124..1586702) 1 NC_008023.1 trigger factor, PPIase 1586702 4064791 MGAS2096_Spy1635 Streptococcus pyogenes MGAS2096 trigger factor, PPIase YP_601231.1 1586124 R 370565 CDS YP_601232.1 94993133 4064792 complement(1586699..1587493) 1 NC_008023.1 trigger factor, PPIase 1587493 ropA 4064792 ropA Streptococcus pyogenes MGAS2096 trigger factor, PPIase YP_601232.1 1586699 R 370565 CDS YP_601233.1 94993134 4064793 1587727..1588572 1 NC_008023.1 mechanosensitive ion channel 1588572 4064793 MGAS2096_Spy1637 Streptococcus pyogenes MGAS2096 mechanosensitive ion channel YP_601233.1 1587727 D 370565 CDS YP_601234.1 94993135 4064794 complement(1588637..1589197) 1 NC_008023.1 hypothetical protein 1589197 4064794 MGAS2096_Spy1638 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601234.1 1588637 R 370565 CDS YP_601235.1 94993136 4064795 complement(1589211..1589681) 1 NC_008023.1 hypothetical protein 1589681 4064795 MGAS2096_Spy1639 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601235.1 1589211 R 370565 CDS YP_601236.1 94993137 4064796 complement(1589671..1590435) 1 NC_008023.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 1590435 thiD 4064796 thiD Streptococcus pyogenes MGAS2096 phosphomethylpyrimidine kinase YP_601236.1 1589671 R 370565 CDS YP_601237.1 94993138 4064797 complement(1590425..1591174) 1 NC_008023.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 1591174 truA 4064797 truA Streptococcus pyogenes MGAS2096 tRNA pseudouridine synthase A YP_601237.1 1590425 R 370565 CDS YP_601238.1 94993139 4064798 complement(1591360..1591767) 1 NC_008023.1 ATP-dependent endopeptidase Clp proteolytic subunit clpP 1591767 4064798 MGAS2096_Spy1642 Streptococcus pyogenes MGAS2096 ATP-dependent endopeptidase Clp proteolytic subunit clpP YP_601238.1 1591360 R 370565 CDS YP_601239.1 94993140 4064615 1597332..1597466 1 NC_008023.1 hypothetical protein 1597466 4064615 MGAS2096_Spy1643 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601239.1 1597332 D 370565 CDS YP_601240.1 94993141 4064616 complement(1597628..1598770) 1 NC_008023.1 glycerate kinase 1598770 4064616 MGAS2096_Spy1644 Streptococcus pyogenes MGAS2096 glycerate kinase YP_601240.1 1597628 R 370565 CDS YP_601241.1 94993142 4064617 1599051..1602029 1 NC_008023.1 Type I restriction-modification system restriction subunit 1602029 hsdR 4064617 hsdR Streptococcus pyogenes MGAS2096 Type I restriction-modification system restriction subunit YP_601241.1 1599051 D 370565 CDS YP_601242.1 94993143 4064618 1602042..1603241 1 NC_008023.1 type I restriction-modification system specificity subunit 1603241 hsdS 4064618 hsdS Streptococcus pyogenes MGAS2096 type I restriction-modification system specificity subunit YP_601242.1 1602042 D 370565 CDS YP_601243.1 94993144 4064619 1603254..1604834 1 NC_008023.1 Type I restriction-modification system methylation subunit 1604834 hsdM 4064619 hsdM Streptococcus pyogenes MGAS2096 Type I restriction-modification system methylation subunit YP_601243.1 1603254 D 370565 CDS YP_601244.1 94993145 4064620 complement(1605044..1605244) 1 NC_008023.1 hypothetical protein 1605244 4064620 MGAS2096_Spy1649 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601244.1 1605044 R 370565 CDS YP_601245.1 94993146 4064621 1605210..1605329 1 NC_008023.1 hypothetical protein 1605329 4064621 MGAS2096_Spy1648 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601245.1 1605210 D 370565 CDS YP_601246.1 94993147 4064622 complement(1605386..1605991) 1 NC_008023.1 transcriptional regulatory protein degU 1605991 salR 4064622 salR Streptococcus pyogenes MGAS2096 transcriptional regulatory protein degU YP_601246.1 1605386 R 370565 CDS YP_601247.1 94993148 4064623 complement(1605972..1607534) 1 NC_008023.1 sensory transduction protein kinase 1607534 4064623 MGAS2096_Spy1651 Streptococcus pyogenes MGAS2096 sensory transduction protein kinase YP_601247.1 1605972 R 370565 CDS YP_601248.1 94993149 4064624 complement(1607574..1609481) 1 NC_008023.1 ABC transporter permease 1609481 salY 4064624 salY Streptococcus pyogenes MGAS2096 ABC transporter permease YP_601248.1 1607574 R 370565 CDS YP_601249.1 94993150 4064625 complement(1609483..1610220) 1 NC_008023.1 ABC transporter ATP-binding protein 1610220 4064625 MGAS2096_Spy1653 Streptococcus pyogenes MGAS2096 ABC transporter ATP-binding protein YP_601249.1 1609483 R 370565 CDS YP_601250.1 94993151 4064626 complement(1610217..1610681) 1 NC_008023.1 lantibiotic ABC transporter ATP-binding protein 1610681 salX 4064626 salX Streptococcus pyogenes MGAS2096 lantibiotic ABC transporter ATP-binding protein YP_601250.1 1610217 R 370565 CDS YP_601251.1 94993152 4064627 complement(1610752..1612377) 1 NC_008023.1 lantibiotic biosynthesis; Serine (threonine) dehydratase 1612377 salB 4064627 salB Streptococcus pyogenes MGAS2096 Serine (threonine) dehydratase YP_601251.1 1610752 R 370565 CDS YP_601252.1 94993153 4064628 complement(1612459..1612614) 1 NC_008023.1 lantibiotic salivaricin A 1612614 salA 4064628 salA Streptococcus pyogenes MGAS2096 lantibiotic salivaricin A YP_601252.1 1612459 R 370565 CDS YP_601253.1 94993154 4064629 complement(1613117..1614523) 1 NC_008023.1 catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase 1614523 lacG 4064629 lacG Streptococcus pyogenes MGAS2096 6-phospho-beta-galactosidase YP_601253.1 1613117 R 370565 CDS YP_601254.1 94993155 4064630 complement(1614596..1616293) 1 NC_008023.1 PTS system lactose-specific transporter subunit IIBC 1616293 lacE 4064630 lacE Streptococcus pyogenes MGAS2096 PTS system lactose-specific transporter subunit IIBC YP_601254.1 1614596 R 370565 CDS YP_601255.1 94993156 4064631 complement(1616293..1616610) 1 NC_008023.1 PTS system lactose-specific transporter subunit IIA 1616610 lacF 4064631 lacF Streptococcus pyogenes MGAS2096 PTS system lactose-specific transporter subunit IIA YP_601255.1 1616293 R 370565 CDS YP_601256.1 94993157 4064632 complement(1616634..1617617) 1 NC_008023.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; tagatose 1,6-diphosphate aldolase 1617617 lacD2 4064632 lacD2 Streptococcus pyogenes MGAS2096 tagatose 1,6-diphosphate aldolase YP_601256.1 1616634 R 370565 CDS YP_601257.1 94993158 4064633 complement(1617621..1618550) 1 NC_008023.1 catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP; tagatose-6-phosphate kinase 1618550 lacC2 4064633 lacC2 Streptococcus pyogenes MGAS2096 tagatose-6-phosphate kinase YP_601257.1 1617621 R 370565 CDS YP_601258.1 94993159 4065283 complement(1618596..1619111) 1 NC_008023.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; galactose-6-phosphate isomerase subunit LacB 1619111 lacB2 4065283 lacB2 Streptococcus pyogenes MGAS2096 galactose-6-phosphate isomerase subunit LacB YP_601258.1 1618596 R 370565 CDS YP_601259.1 94993160 4065284 complement(1619146..1619574) 1 NC_008023.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization; galactose-6-phosphate isomerase subunit LacA 1619574 lacA2 4065284 lacA2 Streptococcus pyogenes MGAS2096 galactose-6-phosphate isomerase subunit LacA YP_601259.1 1619146 R 370565 CDS YP_601260.1 94993161 4065285 1620020..1620793 1 NC_008023.1 lactose phosphotransferase system repressor 1620793 lacR2 4065285 lacR2 Streptococcus pyogenes MGAS2096 lactose phosphotransferase system repressor YP_601260.1 1620020 D 370565 CDS YP_601261.1 94993162 4065286 1621443..1621730 1 NC_008023.1 DNA-damage-inducible protein J 1621730 4065286 MGAS2096_Spy1665 Streptococcus pyogenes MGAS2096 DNA-damage-inducible protein J YP_601261.1 1621443 D 370565 CDS YP_601262.1 94993163 4065287 1621720..1622055 1 NC_008023.1 putative cytoplasmic protein 1622055 4065287 MGAS2096_Spy1666 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_601262.1 1621720 D 370565 CDS YP_601263.1 94993164 4065288 1622207..1622677 1 NC_008023.1 DNA integration/recombination/inversion protein 1622677 4065288 MGAS2096_Spy1667 Streptococcus pyogenes MGAS2096 DNA integration/recombination/inversion protein YP_601263.1 1622207 D 370565 CDS YP_601264.1 94993165 4065289 1623038..1623187 1 NC_008023.1 DNA integration/recombination/inversion protein 1623187 4065289 MGAS2096_Spy1668 Streptococcus pyogenes MGAS2096 DNA integration/recombination/inversion protein YP_601264.1 1623038 D 370565 CDS YP_601265.1 94993166 4065290 complement(1623307..1623699) 1 NC_008023.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 1623699 rpsI 4065290 rpsI Streptococcus pyogenes MGAS2096 30S ribosomal protein S9 YP_601265.1 1623307 R 370565 CDS YP_601266.2 162139123 4065291 complement(1623720..1624166) 1 NC_008023.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 1624166 rplM 4065291 rplM Streptococcus pyogenes MGAS2096 50S ribosomal protein L13 YP_601266.2 1623720 R 370565 CDS YP_601267.1 94993168 4065292 complement(1624384..1624590) 1 NC_008023.1 Cro/CI family transcriptional regulator 1624590 4065292 MGAS2096_Spy1671 Streptococcus pyogenes MGAS2096 Cro/CI family transcriptional regulator YP_601267.1 1624384 R 370565 CDS YP_601268.1 94993169 4065293 complement(1624587..1625126) 1 NC_008023.1 hypothetical protein 1625126 4065293 MGAS2096_Spy1672 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601268.1 1624587 R 370565 CDS YP_601269.1 94993170 4065294 complement(1625229..1626089) 1 NC_008023.1 DegV family fatty acid-binding protein 1626089 4065294 MGAS2096_Spy1673 Streptococcus pyogenes MGAS2096 DegV family fatty acid-binding protein YP_601269.1 1625229 R 370565 CDS YP_601270.1 94993171 4065295 complement(1626186..1626704) 1 NC_008023.1 putative cytoplasmic protein 1626704 4065295 MGAS2096_Spy1674 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_601270.1 1626186 R 370565 CDS YP_601271.1 94993172 4065296 complement(1626708..1627481) 1 NC_008023.1 23S rRNA Gm2251-methyltransferase 1627481 4065296 MGAS2096_Spy1675 Streptococcus pyogenes MGAS2096 23S rRNA Gm2251-methyltransferase YP_601271.1 1626708 R 370565 CDS YP_601272.1 94993173 4065297 complement(1627501..1628298) 1 NC_008023.1 hypothetical protein 1628298 4065297 MGAS2096_Spy1676 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601272.1 1627501 R 370565 CDS YP_601273.1 94993174 4065298 complement(1628494..1628907) 1 NC_008023.1 hypothetical protein 1628907 4065298 MGAS2096_Spy1677 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601273.1 1628494 R 370565 CDS YP_601274.1 94993175 4065299 complement(1628900..1630243) 1 NC_008023.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 1630243 cysS 4065299 cysS Streptococcus pyogenes MGAS2096 cysteinyl-tRNA synthetase YP_601274.1 1628900 R 370565 CDS YP_601275.1 94993176 4065300 complement(1630271..1630501) 1 NC_008023.1 hypothetical protein 1630501 4065300 MGAS2096_Spy1679 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601275.1 1630271 R 370565 CDS YP_601276.1 94993177 4065301 complement(1630514..1630786) 1 NC_008023.1 putative cytoplasmic protein 1630786 4065301 MGAS2096_Spy1680 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_601276.1 1630514 R 370565 CDS YP_601277.1 94993178 4065302 complement(1630980..1631561) 1 NC_008023.1 Serine acetyltransferase 1631561 cysE 4065302 cysE Streptococcus pyogenes MGAS2096 Serine acetyltransferase YP_601277.1 1630980 R 370565 CDS YP_601278.1 94993179 4065039 complement(1631570..1632322) 1 NC_008023.1 hypothetical protein 1632322 4065039 MGAS2096_Spy1682 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601278.1 1631570 R 370565 CDS YP_601279.1 94993180 4065040 complement(1632315..1634420) 1 NC_008023.1 polynucleotide phosphorylase/polyadenylase 1634420 4065040 MGAS2096_Spy1683 Streptococcus pyogenes MGAS2096 polynucleotide phosphorylase/polyadenylase YP_601279.1 1632315 R 370565 CDS YP_601280.1 94993181 4065041 complement(1634729..1635460) 1 NC_008023.1 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity; putative translaldolase 1635460 4065041 MGAS2096_Spy1684 Streptococcus pyogenes MGAS2096 putative translaldolase YP_601280.1 1634729 R 370565 CDS YP_601281.1 94993182 4065042 complement(1635470..1636849) 1 NC_008023.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 1636849 ulaA 4065042 ulaA Streptococcus pyogenes MGAS2096 PTS system ascorbate-specific transporter subunit IIC YP_601281.1 1635470 R 370565 CDS YP_601282.1 94993183 4065043 complement(1636876..1637181) 1 NC_008023.1 PTS system transporter subunit IIB 1637181 4065043 MGAS2096_Spy1686 Streptococcus pyogenes MGAS2096 PTS system transporter subunit IIB YP_601282.1 1636876 R 370565 CDS YP_601283.1 94993184 4065044 complement(1637153..1639315) 1 NC_008023.1 BigG family transcription antiterminator / PTS system, mannitol (Cryptic)-specific IIA component 1639315 4065044 MGAS2096_Spy1687 Streptococcus pyogenes MGAS2096 BigG family transcription antiterminator / PTS system, mannitol (Cryptic)-specific IIA component YP_601283.1 1637153 R 370565 CDS YP_601284.1 94993185 4065045 complement(1639438..1639581) 1 NC_008023.1 hypothetical protein 1639581 4065045 MGAS2096_Spy1688 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601284.1 1639438 R 370565 CDS YP_601285.1 94993186 4065046 complement(1639565..1639834) 1 NC_008023.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 1639834 rpsO 4065046 rpsO Streptococcus pyogenes MGAS2096 30S ribosomal protein S15 YP_601285.1 1639565 R 370565 CDS YP_601286.1 94993187 4065047 complement(1640010..1640210) 1 NC_008023.1 hypothetical protein 1640210 4065047 MGAS2096_Spy1690 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601286.1 1640010 R 370565 CDS YP_601287.1 94993188 4065048 1640336..1640593 1 NC_008023.1 putative transcriptional regulator 1640593 4065048 MGAS2096_Spy1691 Streptococcus pyogenes MGAS2096 putative transcriptional regulator YP_601287.1 1640336 D 370565 CDS YP_601288.1 94993189 4065049 1640720..1641334 1 NC_008023.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1641334 def 4065049 def Streptococcus pyogenes MGAS2096 peptide deformylase YP_601288.1 1640720 D 370565 CDS YP_601289.1 94993190 4065050 complement(1641367..1641909) 1 NC_008023.1 NADPH-dependent FMN reductase family protein 1641909 4065050 MGAS2096_Spy1693 Streptococcus pyogenes MGAS2096 NADPH-dependent FMN reductase family protein YP_601289.1 1641367 R 370565 CDS YP_601290.1 94993191 4065051 complement(1642041..1642499) 1 NC_008023.1 MarR family transcriptional regulator 1642499 4065051 MGAS2096_Spy1694 Streptococcus pyogenes MGAS2096 MarR family transcriptional regulator YP_601290.1 1642041 R 370565 CDS YP_601291.1 94993192 4065052 complement(1642579..1646976) 1 NC_008023.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity; DNA polymerase III PolC 1646976 polC 4065052 polC Streptococcus pyogenes MGAS2096 DNA polymerase III PolC YP_601291.1 1642579 R 370565 CDS YP_601292.1 94993193 4065053 complement(1647230..1649086) 1 NC_008023.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 1649086 proS 4065053 proS Streptococcus pyogenes MGAS2096 prolyl-tRNA synthetase YP_601292.1 1647230 R 370565 CDS YP_601293.1 94993194 4065054 complement(1649284..1650543) 1 NC_008023.1 M50 family membrane endopeptidase 1650543 4065054 MGAS2096_Spy1697 Streptococcus pyogenes MGAS2096 M50 family membrane endopeptidase YP_601293.1 1649284 R 370565 CDS YP_601294.1 94993195 4065055 complement(1650616..1651410) 1 NC_008023.1 phosphatidate cytidylyltransferase 1651410 cdsA 4065055 cdsA Streptococcus pyogenes MGAS2096 phosphatidate cytidylyltransferase YP_601294.1 1650616 R 370565 CDS YP_601295.1 94993196 4065056 complement(1651423..1652172) 1 NC_008023.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 1652172 uppS 4065056 uppS Streptococcus pyogenes MGAS2096 undecaprenyl pyrophosphate synthase YP_601295.1 1651423 R 370565 CDS YP_601296.1 94993197 4065057 complement(1652391..1652786) 1 NC_008023.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 1652786 yajC 4065057 yajC Streptococcus pyogenes MGAS2096 preprotein translocase subunit YajC YP_601296.1 1652391 R 370565 CDS YP_601297.1 94993198 4066117 complement(1652872..1653246) 1 NC_008023.1 thioredoxin 1653246 4066117 MGAS2096_Spy1701 Streptococcus pyogenes MGAS2096 thioredoxin YP_601297.1 1652872 R 370565 CDS YP_601298.1 94993199 4066118 complement(1653361..1656885) 1 NC_008023.1 pullulanase 1656885 pulA 4066118 pulA Streptococcus pyogenes MGAS2096 pullulanase YP_601298.1 1653361 R 370565 CDS YP_601299.1 94993200 4066119 1656842..1657072 1 NC_008023.1 hypothetical protein 1657072 4066119 MGAS2096_Spy1702 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601299.1 1656842 D 370565 CDS YP_601300.1 94993201 4066120 complement(1657056..1658690) 1 NC_008023.1 glucan 1,6-alpha-glucosidase 1658690 dexB 4066120 dexB Streptococcus pyogenes MGAS2096 glucan 1,6-alpha-glucosidase YP_601300.1 1657056 R 370565 CDS YP_601301.1 94993202 4066121 complement(1658798..1659931) 1 NC_008023.1 sugar ABC transporter ATP-binding protein 1659931 msmK 4066121 msmK Streptococcus pyogenes MGAS2096 sugar ABC transporter ATP-binding protein YP_601301.1 1658798 R 370565 CDS YP_601302.1 94993203 4066122 complement(1660229..1661119) 1 NC_008023.1 hypothetical protein 1661119 lrp 4066122 lrp Streptococcus pyogenes MGAS2096 hypothetical protein YP_601302.1 1660229 R 370565 CDS YP_601303.1 94993204 4066123 1661418..1662740 1 NC_008023.1 streptokinase 1662740 ska 4066123 ska Streptococcus pyogenes MGAS2096 streptokinase YP_601303.1 1661418 D 370565 CDS YP_601304.1 94993205 4066124 complement(1662989..1663282) 1 NC_008023.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 1663282 4066124 MGAS2096_Spy1708 Streptococcus pyogenes MGAS2096 D-tyrosyl-tRNA(Tyr) deacylase YP_601304.1 1662989 R 370565 CDS YP_601305.1 94993206 4066125 complement(1663297..1665528) 1 NC_008023.1 bifunctional; GTP pyrophosphokinase / guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase 1665528 relA 4066125 relA Streptococcus pyogenes MGAS2096 GTP pyrophosphokinase / guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase YP_601305.1 1663297 R 370565 CDS YP_601306.1 94993207 4066126 complement(1665768..1667045) 1 NC_008023.1 collagen-like surface protein 1667045 sclA 4066126 sclA Streptococcus pyogenes MGAS2096 collagen-like surface protein YP_601306.1 1665768 R 370565 CDS YP_601307.1 94993208 4066127 1667427..1667753 1 NC_008023.1 NrdI protein 1667753 4066127 MGAS2096_Spy1711 Streptococcus pyogenes MGAS2096 NrdI protein YP_601307.1 1667427 D 370565 CDS YP_601308.1 94993209 4066128 1667699..1667887 1 NC_008023.1 NrdI protein 1667887 4066128 MGAS2096_Spy1712 Streptococcus pyogenes MGAS2096 NrdI protein YP_601308.1 1667699 D 370565 CDS YP_601309.1 94993210 4066129 complement(1668282..1669121) 1 NC_008023.1 endonuclease/exonuclease/phosphatase family protein 1669121 4066129 MGAS2096_Spy1713 Streptococcus pyogenes MGAS2096 endonuclease/exonuclease/phosphatase family protein YP_601309.1 1668282 R 370565 CDS YP_601310.1 94993211 4066130 complement(1669183..1671369) 1 NC_008023.1 PTS system glucose-specific transporter subunit IIABC 1671369 4066130 MGAS2096_Spy1714 Streptococcus pyogenes MGAS2096 PTS system glucose-specific transporter subunit IIABC YP_601310.1 1669183 R 370565 CDS YP_601311.1 94993212 4066131 complement(1671725..1672474) 1 NC_008023.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 1672474 4066131 MGAS2096_Spy1715 Streptococcus pyogenes MGAS2096 16S ribosomal RNA methyltransferase RsmE YP_601311.1 1671725 R 370565 CDS YP_601312.1 94993213 4066132 complement(1672474..1673427) 1 NC_008023.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase 1673427 prmA 4066132 prmA Streptococcus pyogenes MGAS2096 50S ribosomal protein L11 methyltransferase YP_601312.1 1672474 R 370565 CDS YP_601313.1 94993214 4066133 complement(1673498..1673968) 1 NC_008023.1 hypothetical protein 1673968 4066133 MGAS2096_Spy1717 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601313.1 1673498 R 370565 CDS YP_601314.1 94993215 4066134 complement(1674033..1674233) 1 NC_008023.1 RhuM 1674233 4066134 MGAS2096_Spy1718 Streptococcus pyogenes MGAS2096 RhuM YP_601314.1 1674033 R 370565 CDS YP_601315.1 94993216 4066135 1674363..1674560 1 NC_008023.1 ArpU family phage encoded transcriptional regulator 1674560 4066135 MGAS2096_Spy1719 Streptococcus pyogenes MGAS2096 ArpU family phage encoded transcriptional regulator YP_601315.1 1674363 D 370565 CDS YP_601316.1 94993217 4066136 1674662..1675525 1 NC_008023.1 transposase 1675525 4066136 MGAS2096_Spy1720 Streptococcus pyogenes MGAS2096 transposase YP_601316.1 1674662 D 370565 CDS YP_601317.1 94993218 4065907 1675512..1675667 1 NC_008023.1 hypothetical protein 1675667 4065907 MGAS2096_Spy1721 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601317.1 1675512 D 370565 CDS YP_601318.1 94993219 4065908 complement(1675669..1676010) 1 NC_008023.1 hypothetical protein 1676010 4065908 MGAS2096_Spy1722 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601318.1 1675669 R 370565 CDS YP_601319.1 94993220 4065909 1676503..1676694 1 NC_008023.1 hypothetical protein 1676694 4065909 MGAS2096_Spy1723 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601319.1 1676503 D 370565 CDS YP_601320.1 94993221 4065910 1676801..1678564 1 NC_008023.1 bifunctional; Para-aminobenzoate synthetase component I / 4-amino-4-deoxychorismate lyase 1678564 4065910 MGAS2096_Spy1724 Streptococcus pyogenes MGAS2096 Para-aminobenzoate synthetase component I / 4-amino-4-deoxychorismate lyase YP_601320.1 1676801 D 370565 CDS YP_601321.1 94993222 4065911 1678597..1679163 1 NC_008023.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 1679163 trpG 4065911 trpG Streptococcus pyogenes MGAS2096 anthranilate synthase component II YP_601321.1 1678597 D 370565 CDS YP_601322.1 94993223 4065912 1679196..1680464 1 NC_008023.1 recombination factor protein RarA 1680464 4065912 MGAS2096_Spy1726 Streptococcus pyogenes MGAS2096 recombination factor protein RarA YP_601322.1 1679196 D 370565 CDS YP_601323.1 94993224 4065914 1680921..1681403 1 NC_008023.1 acetyltransferase 1681403 4065914 MGAS2096_Spy1727 Streptococcus pyogenes MGAS2096 acetyltransferase YP_601323.1 1680921 D 370565 CDS YP_601324.1 94993225 4065915 1681458..1681928 1 NC_008023.1 topology modulation protein 1681928 flaR 4065915 flaR Streptococcus pyogenes MGAS2096 topology modulation protein YP_601324.1 1681458 D 370565 CDS YP_601325.1 94993226 4065916 complement(1682092..1682256) 1 NC_008023.1 hypothetical protein 1682256 4065916 MGAS2096_Spy1730 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601325.1 1682092 R 370565 CDS YP_601326.1 94993227 4065917 1682213..1682914 1 NC_008023.1 enterotoxin 1682914 smeZ 4065917 smeZ Streptococcus pyogenes MGAS2096 enterotoxin YP_601326.1 1682213 D 370565 CDS YP_601327.1 94993228 4065918 complement(1683241..1683465) 1 NC_008023.1 putative cytoplasmic protein 1683465 4065918 MGAS2096_Spy1731 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_601327.1 1683241 R 370565 CDS YP_601328.1 94993229 4065919 1683638..1685272 1 NC_008023.1 dipeptide-binding protein 1685272 dppA 4065919 dppA Streptococcus pyogenes MGAS2096 dipeptide-binding protein YP_601328.1 1683638 D 370565 CDS YP_601329.1 94993230 4065920 1685385..1686362 1 NC_008023.1 peptide ABC transporter permease 1686362 dppB 4065920 dppB Streptococcus pyogenes MGAS2096 peptide ABC transporter permease YP_601329.1 1685385 D 370565 CDS YP_601330.1 94993231 4065921 1686359..1687180 1 NC_008023.1 peptide ABC transporter permease 1687180 dppC 4065921 dppC Streptococcus pyogenes MGAS2096 peptide ABC transporter permease YP_601330.1 1686359 D 370565 CDS YP_601331.1 94993232 4065922 1687192..1687995 1 NC_008023.1 peptide ABC transporter ATP-binding protein 1687995 dppD 4065922 dppD Streptococcus pyogenes MGAS2096 peptide ABC transporter ATP-binding protein YP_601331.1 1687192 D 370565 CDS YP_601332.1 94993233 4065923 1687979..1688605 1 NC_008023.1 peptide ABC transporter ATP-binding protein 1688605 dppE 4065923 dppE Streptococcus pyogenes MGAS2096 peptide ABC transporter ATP-binding protein YP_601332.1 1687979 D 370565 CDS YP_601333.1 94993234 4065924 complement(1688688..1688888) 1 NC_008023.1 hypothetical protein 1688888 4065924 MGAS2096_Spy1737 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601333.1 1688688 R 370565 CDS YP_601334.1 94993235 4064557 complement(1689057..1691399) 1 NC_008023.1 histidine triad protein 1691399 4064557 MGAS2096_Spy1738 Streptococcus pyogenes MGAS2096 histidine triad protein YP_601334.1 1689057 R 370565 CDS YP_601335.1 94993236 4064558 complement(1691338..1691526) 1 NC_008023.1 putative cytoplasmic protein 1691526 4064558 MGAS2096_Spy1739 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_601335.1 1691338 R 370565 CDS YP_601336.1 94993237 4064559 complement(1691539..1692459) 1 NC_008023.1 laminin-binding surface protein 1692459 lmb 4064559 lmb Streptococcus pyogenes MGAS2096 laminin-binding surface protein YP_601336.1 1691539 R 370565 CDS YP_601337.1 94993238 4064560 complement(1692537..1692653) 1 NC_008023.1 hypothetical protein 1692653 4064560 MGAS2096_Spy1741 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601337.1 1692537 R 370565 CDS YP_601338.1 94993239 4064561 complement(1692637..1693779) 1 NC_008023.1 transposase 1693779 4064561 MGAS2096_Spy1742 Streptococcus pyogenes MGAS2096 transposase YP_601338.1 1692637 R 370565 CDS YP_601339.1 94993240 4064562 complement(1693824..1693976) 1 NC_008023.1 hypothetical protein 1693976 4064562 MGAS2096_Spy1743 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601339.1 1693824 R 370565 CDS YP_601340.1 94993241 4064563 complement(1694021..1697524) 1 NC_008023.1 C5A peptidase 1697524 scpA 4064563 scpA Streptococcus pyogenes MGAS2096 C5A peptidase YP_601340.1 1694021 R 370565 CDS YP_601341.1 94993242 4064564 1697958..1698617 1 NC_008023.1 transposase 1698617 4064564 MGAS2096_Spy1745 Streptococcus pyogenes MGAS2096 transposase YP_601341.1 1697958 D 370565 CDS YP_601342.1 94993243 4064565 1698595..1699401 1 NC_008023.1 transposase 1699401 4064565 MGAS2096_Spy1746 Streptococcus pyogenes MGAS2096 transposase YP_601342.1 1698595 D 370565 CDS YP_601343.1 94993244 4064566 complement(1699649..1700593) 1 NC_008023.1 complement inhibitor protein 1700593 sic1-01 4064566 sic1-01 Streptococcus pyogenes MGAS2096 complement inhibitor protein YP_601343.1 1699649 R 370565 CDS YP_601344.1 94993245 4064567 complement(1700783..1704286) 1 NC_008023.1 transcriptional regulator 1704286 mga 4064567 mga Streptococcus pyogenes MGAS2096 transcriptional regulator YP_601344.1 1700783 R 370565 CDS YP_601345.1 94993246 4064568 1704671..1704856 1 NC_008023.1 hypothetical protein 1704856 4064568 MGAS2096_Spy1749 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601345.1 1704671 D 370565 CDS YP_601346.1 94993247 4064569 complement(1704962..1705213) 1 NC_008023.1 immunogenic protein 1705213 4064569 MGAS2096_Spy1750 Streptococcus pyogenes MGAS2096 immunogenic protein YP_601346.1 1704962 R 370565 CDS YP_601347.1 94993248 4064570 complement(1705291..1706919) 1 NC_008023.1 immunogenic secreted protein 1706919 isp 4064570 isp Streptococcus pyogenes MGAS2096 immunogenic secreted protein YP_601347.1 1705291 R 370565 CDS YP_601348.1 94993249 4064571 complement(1707021..1708409) 1 NC_008023.1 two-component system histidine kinase 1708409 ihk 4064571 ihk Streptococcus pyogenes MGAS2096 two-component system histidine kinase YP_601348.1 1707021 R 370565 CDS YP_601349.1 94993250 4064572 complement(1708406..1709059) 1 NC_008023.1 two-component response regulator 1709059 irr 4064572 irr Streptococcus pyogenes MGAS2096 two-component response regulator YP_601349.1 1708406 R 370565 CDS YP_601350.1 94993251 4064573 complement(1709153..1710370) 1 NC_008023.1 ABC transporter permease 1710370 4064573 MGAS2096_Spy1754 Streptococcus pyogenes MGAS2096 ABC transporter permease YP_601350.1 1709153 R 370565 CDS YP_601351.1 94993252 4064574 complement(1710383..1711057) 1 NC_008023.1 ABC transporter ATP-binding protein 1711057 4064574 MGAS2096_Spy1755 Streptococcus pyogenes MGAS2096 ABC transporter ATP-binding protein YP_601351.1 1710383 R 370565 CDS YP_601352.1 94993253 4064575 complement(1711044..1712312) 1 NC_008023.1 periplasmic protein of efflux system 1712312 4064575 MGAS2096_Spy1756 Streptococcus pyogenes MGAS2096 periplasmic protein of efflux system YP_601352.1 1711044 R 370565 CDS YP_601353.1 94993254 4064576 complement(1712736..1712906) 1 NC_008023.1 hypothetical protein 1712906 4064576 MGAS2096_Spy1758 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601353.1 1712736 R 370565 CDS YP_601354.1 94993255 4064752 1712875..1713183 1 NC_008023.1 hypothetical protein 1713183 4064752 MGAS2096_Spy1757 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601354.1 1712875 D 370565 CDS YP_601355.1 94993256 4064753 complement(1713164..1713460) 1 NC_008023.1 hypothetical protein 1713460 4064753 MGAS2096_Spy1759 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601355.1 1713164 R 370565 CDS YP_601356.1 94993257 4064754 complement(1713602..1715569) 1 NC_008023.1 fibronectin-binding protein 1715569 4064754 MGAS2096_Spy1760 Streptococcus pyogenes MGAS2096 fibronectin-binding protein YP_601356.1 1713602 R 370565 CDS YP_601357.1 94993258 4064755 complement(1715749..1716555) 1 NC_008023.1 fibronectin-binding protein 1716555 4064755 MGAS2096_Spy1761 Streptococcus pyogenes MGAS2096 fibronectin-binding protein YP_601357.1 1715749 R 370565 CDS YP_601358.1 94993259 4064756 complement(1716567..1718807) 1 NC_008023.1 fibronectin-binding protein 1718807 4064756 MGAS2096_Spy1762 Streptococcus pyogenes MGAS2096 fibronectin-binding protein YP_601358.1 1716567 R 370565 CDS YP_601359.1 94993260 4064757 1719230..1719466 1 NC_008023.1 putative cytoplasmic protein 1719466 4064757 MGAS2096_Spy1763 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_601359.1 1719230 D 370565 CDS YP_601360.1 94993261 4064758 complement(1719737..1720690) 1 NC_008023.1 cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein; foldase PrsA 1720690 4064758 MGAS2096_Spy1764 Streptococcus pyogenes MGAS2096 foldase PrsA YP_601360.1 1719737 R 370565 CDS YP_601361.1 94993262 4064759 complement(1720722..1721039) 1 NC_008023.1 hypothetical protein 1721039 4064759 MGAS2096_Spy1765 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601361.1 1720722 R 370565 CDS YP_601362.1 94993263 4064760 complement(1721146..1721451) 1 NC_008023.1 streptopain 1721451 4064760 MGAS2096_Spy1766 Streptococcus pyogenes MGAS2096 streptopain YP_601362.1 1721146 R 370565 CDS YP_601363.1 94993264 4064761 complement(1721453..1722649) 1 NC_008023.1 streptopain 1722649 speB 4064761 speB Streptococcus pyogenes MGAS2096 streptopain YP_601363.1 1721453 R 370565 CDS YP_601364.1 94993265 4064762 complement(1722921..1723091) 1 NC_008023.1 hypothetical protein 1723091 4064762 MGAS2096_Spy1768 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601364.1 1722921 R 370565 CDS YP_601365.1 94993266 4064763 1723175..1723306 1 NC_008023.1 hypothetical protein 1723306 4064763 MGAS2096_Spy1769 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601365.1 1723175 D 370565 CDS YP_601366.1 94993267 4064764 1723590..1724432 1 NC_008023.1 transcriptional regulator 1724432 rgg 4064764 rgg Streptococcus pyogenes MGAS2096 transcriptional regulator YP_601366.1 1723590 D 370565 CDS YP_601367.1 94993268 4064765 complement(1724673..1724897) 1 NC_008023.1 streptodornase 1724897 4064765 MGAS2096_Spy1771 Streptococcus pyogenes MGAS2096 streptodornase YP_601367.1 1724673 R 370565 CDS YP_601368.1 94993269 4064766 complement(1724921..1725517) 1 NC_008023.1 streptodornase 1725517 spd 4064766 spd Streptococcus pyogenes MGAS2096 streptodornase YP_601368.1 1724921 R 370565 CDS YP_601369.1 94993270 4064767 1725571..1725699 1 NC_008023.1 hypothetical protein 1725699 4064767 MGAS2096_Spy1773 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601369.1 1725571 D 370565 CDS YP_601370.1 94993271 4064768 1725851..1726360 1 NC_008023.1 low temperature requirement C protein 1726360 4064768 MGAS2096_Spy1774 Streptococcus pyogenes MGAS2096 low temperature requirement C protein YP_601370.1 1725851 D 370565 CDS YP_601371.1 94993272 4064769 complement(1726442..1727530) 1 NC_008023.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 1727530 gldA 4064769 gldA Streptococcus pyogenes MGAS2096 glycerol dehydrogenase YP_601371.1 1726442 R 370565 CDS YP_601372.1 94993273 4064770 complement(1727587..1728255) 1 NC_008023.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 1728255 mipB 4064770 mipB Streptococcus pyogenes MGAS2096 fructose-6-phosphate aldolase YP_601372.1 1727587 R 370565 CDS YP_601373.1 94993274 4065136 complement(1728268..1730685) 1 NC_008023.1 formate acetyltransferase 1730685 pflD 4065136 pflD Streptococcus pyogenes MGAS2096 formate acetyltransferase YP_601373.1 1728268 R 370565 CDS YP_601374.1 94993275 4065137 complement(1730896..1732200) 1 NC_008023.1 PTS system cellobiose-specific transporter subunit IIC 1732200 4065137 MGAS2096_Spy1778 Streptococcus pyogenes MGAS2096 PTS system cellobiose-specific transporter subunit IIC YP_601374.1 1730896 R 370565 CDS YP_601375.1 94993276 4065138 complement(1732210..1732518) 1 NC_008023.1 PTS system cellobiose-specific transporter subunit IIB 1732518 4065138 MGAS2096_Spy1779 Streptococcus pyogenes MGAS2096 PTS system cellobiose-specific transporter subunit IIB YP_601375.1 1732210 R 370565 CDS YP_601376.1 94993277 4065139 complement(1732546..1732866) 1 NC_008023.1 PTS system cellobiose-specific transporter subunit IIA 1732866 4065139 MGAS2096_Spy1780 Streptococcus pyogenes MGAS2096 PTS system cellobiose-specific transporter subunit IIA YP_601376.1 1732546 R 370565 CDS YP_601377.1 94993278 4065140 complement(1733153..1734133) 1 NC_008023.1 sorbitol operon regulator 1734133 4065140 MGAS2096_Spy1781 Streptococcus pyogenes MGAS2096 sorbitol operon regulator YP_601377.1 1733153 R 370565 CDS YP_601378.1 94993279 4065141 complement(1734149..1734898) 1 NC_008023.1 DeoR family transcriptional regulator 1734898 4065141 MGAS2096_Spy1782 Streptococcus pyogenes MGAS2096 DeoR family transcriptional regulator YP_601378.1 1734149 R 370565 CDS YP_601379.1 94993280 4065142 1734964..1735794 1 NC_008023.1 pyruvate formate-lyase activating enzyme 1735794 4065142 MGAS2096_Spy1783 Streptococcus pyogenes MGAS2096 pyruvate formate-lyase activating enzyme YP_601379.1 1734964 D 370565 CDS YP_601380.1 94993281 4065143 1735829..1736029 1 NC_008023.1 hypothetical protein 1736029 4065143 MGAS2096_Spy1784 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601380.1 1735829 D 370565 CDS YP_601381.1 94993282 4065144 complement(1736031..1736207) 1 NC_008023.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 1736207 secE 4065144 secE Streptococcus pyogenes MGAS2096 preprotein translocase subunit SecE YP_601381.1 1736031 R 370565 CDS YP_601382.1 94993283 4065145 complement(1736221..1736373) 1 NC_008023.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 1736373 rpmG 4065145 rpmG Streptococcus pyogenes MGAS2096 50S ribosomal protein L33 YP_601382.1 1736221 R 370565 CDS YP_601383.1 94993284 4065146 complement(1736422..1736595) 1 NC_008023.1 multimodular transpeptidase-transglycosylase PBP 2A 1736595 4065146 MGAS2096_Spy1787 Streptococcus pyogenes MGAS2096 multimodular transpeptidase-transglycosylase PBP 2A YP_601383.1 1736422 R 370565 CDS YP_601384.1 94993285 4065147 complement(1736573..1738759) 1 NC_008023.1 multimodular transpeptidase-transglycosylase PBP 2A 1738759 pbp2A 4065147 pbp2A Streptococcus pyogenes MGAS2096 multimodular transpeptidase-transglycosylase PBP 2A YP_601384.1 1736573 R 370565 CDS YP_601385.1 94993286 4065148 complement(1738798..1739178) 1 NC_008023.1 translation initiation inhibitor 1739178 4065148 MGAS2096_Spy1789 Streptococcus pyogenes MGAS2096 translation initiation inhibitor YP_601385.1 1738798 R 370565 CDS YP_601386.1 94993287 4065149 1739669..1739860 1 NC_008023.1 putative cytoplasmic protein 1739860 4065149 MGAS2096_Spy1790 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_601386.1 1739669 D 370565 CDS YP_601387.1 94993288 4065150 1739754..1740755 1 NC_008023.1 ribosomal large subunit pseudouridine synthase D 1740755 4065150 MGAS2096_Spy1791 Streptococcus pyogenes MGAS2096 ribosomal large subunit pseudouridine synthase D YP_601387.1 1739754 D 370565 CDS YP_601388.1 94993289 4065151 complement(1740844..1742568) 1 NC_008023.1 hypothetical protein 1742568 4065151 MGAS2096_Spy1792 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601388.1 1740844 R 370565 CDS YP_601389.1 94993290 4065152 1742692..1744230 1 NC_008023.1 dipeptidase 1744230 4065152 MGAS2096_Spy1793 Streptococcus pyogenes MGAS2096 dipeptidase YP_601389.1 1742692 D 370565 CDS YP_601390.1 94993291 4065153 complement(1744942..1745211) 1 NC_008023.1 MutR family transcriptional regulator 1745211 4065153 MGAS2096_Spy1794 Streptococcus pyogenes MGAS2096 MutR family transcriptional regulator YP_601390.1 1744942 R 370565 CDS YP_601391.2 162139122 4065154 complement(1745459..1747090) 1 NC_008023.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 1747090 groEL 4065154 groEL Streptococcus pyogenes MGAS2096 chaperonin GroEL YP_601391.2 1745459 R 370565 CDS YP_601392.2 162139121 4065155 complement(1747126..1747416) 1 NC_008023.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 1747416 groES 4065155 groES Streptococcus pyogenes MGAS2096 co-chaperonin GroES YP_601392.2 1747126 R 370565 CDS YP_601393.1 94993294 4065557 complement(1747594..1749012) 1 NC_008023.1 negative regulator of genetic competence clpC/mecB 1749012 clpC 4065557 clpC Streptococcus pyogenes MGAS2096 negative regulator of genetic competence clpC/mecB YP_601393.1 1747594 R 370565 CDS YP_601394.1 94993295 4065558 complement(1748969..1750039) 1 NC_008023.1 negative regulator of genetic competence clpC/mecB 1750039 4065558 MGAS2096_Spy1798 Streptococcus pyogenes MGAS2096 negative regulator of genetic competence clpC/mecB YP_601394.1 1748969 R 370565 CDS YP_601395.1 94993296 4065559 complement(1750039..1750500) 1 NC_008023.1 transcriptional regulator ctsR 1750500 ctsR 4065559 ctsR Streptococcus pyogenes MGAS2096 transcriptional regulator ctsR YP_601395.1 1750039 R 370565 CDS YP_601396.1 94993297 4065560 complement(1750696..1750905) 1 NC_008023.1 cold shock protein 1750905 csp 4065560 csp Streptococcus pyogenes MGAS2096 cold shock protein YP_601396.1 1750696 R 370565 CDS YP_601397.1 94993298 4065562 1751894..1752454 1 NC_008023.1 peroxiredoxin 1752454 ahpC 4065562 ahpC Streptococcus pyogenes MGAS2096 peroxiredoxin YP_601397.1 1751894 D 370565 CDS YP_601398.1 94993299 4065563 1752475..1754007 1 NC_008023.1 bifunctional; peroxiredoxin reductase (NAD(P)H) / NADH oxidase H2O2-forming 1754007 ahpF 4065563 ahpF Streptococcus pyogenes MGAS2096 peroxiredoxin reductase (NAD(P)H) / NADH oxidase H2O2-forming YP_601398.1 1752475 D 370565 CDS YP_601399.1 94993300 4065564 complement(1754065..1755351) 1 NC_008023.1 catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway; imidazolonepropionase 1755351 hutI 4065564 hutI Streptococcus pyogenes MGAS2096 imidazolonepropionase YP_601399.1 1754065 R 370565 CDS YP_601400.1 94993301 4065565 1755621..1757651 1 NC_008023.1 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism; urocanate hydratase 1757651 hutU 4065565 hutU Streptococcus pyogenes MGAS2096 urocanate hydratase YP_601400.1 1755621 D 370565 CDS YP_601401.1 94993302 4065566 1757739..1758638 1 NC_008023.1 glutamate formiminotransferase 1758638 4065566 MGAS2096_Spy1805 Streptococcus pyogenes MGAS2096 glutamate formiminotransferase YP_601401.1 1757739 D 370565 CDS YP_601402.1 94993303 4065567 1758649..1759275 1 NC_008023.1 formiminotetrahydrofolate cyclodeaminase 1759275 4065567 MGAS2096_Spy1806 Streptococcus pyogenes MGAS2096 formiminotetrahydrofolate cyclodeaminase YP_601402.1 1758649 D 370565 CDS YP_601403.1 94993304 4065568 1759293..1760966 1 NC_008023.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase 1760966 fhs2 4065568 fhs2 Streptococcus pyogenes MGAS2096 formate--tetrahydrofolate ligase YP_601403.1 1759293 D 370565 CDS YP_601404.1 94993305 4065569 1760967..1761584 1 NC_008023.1 putative cytoplasmic protein 1761584 4065569 MGAS2096_Spy1808 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_601404.1 1760967 D 370565 CDS YP_601405.1 94993306 4065570 1761804..1763156 1 NC_008023.1 amino acid permease 1763156 4065570 MGAS2096_Spy1809 Streptococcus pyogenes MGAS2096 amino acid permease YP_601405.1 1761804 D 370565 CDS YP_601406.2 162139120 4065571 1763167..1764708 1 NC_008023.1 catalyzes the degradation of histidine to urocanate and ammmonia; histidine ammonia-lyase 1764708 hutH 4065571 hutH Streptococcus pyogenes MGAS2096 histidine ammonia-lyase YP_601406.2 1763167 D 370565 CDS YP_601407.1 94993308 4065572 1764885..1765880 1 NC_008023.1 catalyzes the formation of glutamate and formamide from N-formimidoyl-L-glutamate; formimidoylglutamase 1765880 hutG 4065572 hutG Streptococcus pyogenes MGAS2096 formimidoylglutamase YP_601407.1 1764885 D 370565 CDS YP_601408.1 94993309 4065573 complement(1765911..1768985) 1 NC_008023.1 LuxR family transcriptional regulator 1768985 4065573 MGAS2096_Spy1812 Streptococcus pyogenes MGAS2096 LuxR family transcriptional regulator YP_601408.1 1765911 R 370565 CDS YP_601409.1 94993310 4065574 1769289..1770056 1 NC_008023.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 1770056 rpsB 4065574 rpsB Streptococcus pyogenes MGAS2096 30S ribosomal protein S2 YP_601409.1 1769289 D 370565 CDS YP_601410.2 162139119 4065712 1770190..1771230 1 NC_008023.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 1771230 tsf 4065712 tsf Streptococcus pyogenes MGAS2096 elongation factor Ts YP_601410.2 1770190 D 370565 CDS YP_601411.1 94993312 4065713 complement(1771397..1773292) 1 NC_008023.1 oligoendopeptidase O 1773292 pepO 4065713 pepO Streptococcus pyogenes MGAS2096 oligoendopeptidase O YP_601411.1 1771397 R 370565 CDS YP_601412.1 94993313 4065714 complement(1773500..1775128) 1 NC_008023.1 trehalose-6-phosphate hydrolase 1775128 dexS 4065714 dexS Streptococcus pyogenes MGAS2096 trehalose-6-phosphate hydrolase YP_601412.1 1773500 R 370565 CDS YP_601413.1 94993314 4065715 complement(1775195..1777219) 1 NC_008023.1 bifunctional; PTS system, trehalose-specific IIBC component / PTS system, trehalose-specific IIA component 1777219 4065715 MGAS2096_Spy1817 Streptococcus pyogenes MGAS2096 PTS system, trehalose-specific IIBC component / PTS system, trehalose-specific IIA component YP_601413.1 1775195 R 370565 CDS YP_601414.1 94993315 4065716 1777430..1778143 1 NC_008023.1 trehalose operon transcriptional repressor 1778143 4065716 MGAS2096_Spy1818 Streptococcus pyogenes MGAS2096 trehalose operon transcriptional repressor YP_601414.1 1777430 D 370565 CDS YP_601415.1 94993316 4065717 complement(1778422..1778760) 1 NC_008023.1 MarR family transcriptional regulator 1778760 4065717 MGAS2096_Spy1819 Streptococcus pyogenes MGAS2096 MarR family transcriptional regulator YP_601415.1 1778422 R 370565 CDS YP_601416.1 94993317 4065718 1778946..1779701 1 NC_008023.1 glyoxalase family protein 1779701 4065718 MGAS2096_Spy1820 Streptococcus pyogenes MGAS2096 glyoxalase family protein YP_601416.1 1778946 D 370565 CDS YP_601417.1 94993318 4065719 1779836..1780567 1 NC_008023.1 hypothetical protein 1780567 yaaA 4065719 yaaA Streptococcus pyogenes MGAS2096 hypothetical protein YP_601417.1 1779836 D 370565 CDS YP_601418.1 94993319 4065720 complement(1780741..1781358) 1 NC_008023.1 anaerobic ribonucleoside-triphosphate reductase activating protein 1781358 nrdG 4065720 nrdG Streptococcus pyogenes MGAS2096 anaerobic ribonucleoside-triphosphate reductase activating protein YP_601418.1 1780741 R 370565 CDS YP_601419.1 94993320 4065721 complement(1781355..1781864) 1 NC_008023.1 acetyltransferase 1781864 4065721 MGAS2096_Spy1823 Streptococcus pyogenes MGAS2096 acetyltransferase YP_601419.1 1781355 R 370565 CDS YP_601420.1 94993321 4065722 complement(1781873..1782814) 1 NC_008023.1 NAD-dependent oxidoreductase 1782814 4065722 MGAS2096_Spy1824 Streptococcus pyogenes MGAS2096 NAD-dependent oxidoreductase YP_601420.1 1781873 R 370565 CDS YP_601421.1 94993322 4065723 complement(1782837..1782983) 1 NC_008023.1 hypothetical protein 1782983 4065723 MGAS2096_Spy1825 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601421.1 1782837 R 370565 CDS YP_601422.1 94993323 4065724 complement(1783165..1785363) 1 NC_008023.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 1785363 nrdD 4065724 nrdD Streptococcus pyogenes MGAS2096 anaerobic ribonucleoside triphosphate reductase YP_601422.1 1783165 R 370565 CDS YP_601423.1 94993324 4065725 complement(1785460..1787019) 1 NC_008023.1 hypothetical protein 1787019 4065725 MGAS2096_Spy1827 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601423.1 1785460 R 370565 CDS YP_601424.1 94993325 4065726 complement(1787470..1787736) 1 NC_008023.1 putative cytoplasmic protein 1787736 4065726 MGAS2096_Spy1828 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_601424.1 1787470 R 370565 CDS YP_601425.1 94993326 4065727 complement(1787748..1788167) 1 NC_008023.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 1788167 4065727 MGAS2096_Spy1829 Streptococcus pyogenes MGAS2096 Holliday junction resolvase-like protein YP_601425.1 1787748 R 370565 CDS YP_601426.1 94993327 4065728 complement(1788164..1788433) 1 NC_008023.1 hypothetical protein 1788433 4065728 MGAS2096_Spy1830 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601426.1 1788164 R 370565 CDS YP_601427.1 94993328 4065729 complement(1788546..1788944) 1 NC_008023.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx 1788944 spxA 4065729 spxA Streptococcus pyogenes MGAS2096 transcriptional regulator Spx YP_601427.1 1788546 R 370565 CDS YP_601428.1 94993329 4065730 complement(1789235..1790371) 1 NC_008023.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 1790371 recA 4065730 recA Streptococcus pyogenes MGAS2096 recombinase A YP_601428.1 1789235 R 370565 CDS YP_601429.1 94993330 4065731 complement(1790460..1791731) 1 NC_008023.1 competence damage-inducible protein A 1791731 cinA 4065731 cinA Streptococcus pyogenes MGAS2096 competence damage-inducible protein A YP_601429.1 1790460 R 370565 CDS YP_601430.1 94993331 4066260 complement(1791800..1792369) 1 NC_008023.1 DNA-3-methyladenine glycosylase 1792369 tag 4066260 tag Streptococcus pyogenes MGAS2096 DNA-3-methyladenine glycosylase YP_601430.1 1791800 R 370565 CDS YP_601431.1 94993332 4066261 complement(1792370..1792966) 1 NC_008023.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 1792966 ruvA 4066261 ruvA Streptococcus pyogenes MGAS2096 Holliday junction DNA helicase RuvA YP_601431.1 1792370 R 370565 CDS YP_601432.1 94993333 4066262 complement(1792968..1794188) 1 NC_008023.1 multidrug resistance protein imrP 1794188 lmrP 4066262 lmrP Streptococcus pyogenes MGAS2096 multidrug resistance protein imrP YP_601432.1 1792968 R 370565 CDS YP_601433.1 94993334 4066263 complement(1794199..1796181) 1 NC_008023.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 1796181 mutL 4066263 mutL Streptococcus pyogenes MGAS2096 DNA mismatch repair protein YP_601433.1 1794199 R 370565 CDS YP_601434.1 94993335 4066264 complement(1796310..1798865) 1 NC_008023.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 1798865 mutS 4066264 mutS Streptococcus pyogenes MGAS2096 DNA mismatch repair protein MutS YP_601434.1 1796310 R 370565 CDS YP_601435.1 94993336 4066265 complement(1799205..1799642) 1 NC_008023.1 arginine repressor ArgR 1799642 argR2 4066265 argR2 Streptococcus pyogenes MGAS2096 arginine repressor ArgR YP_601435.1 1799205 R 370565 CDS YP_601436.1 94993337 4066266 1799933..1801624 1 NC_008023.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1801624 argS 4066266 argS Streptococcus pyogenes MGAS2096 arginyl-tRNA synthetase YP_601436.1 1799933 D 370565 CDS YP_601437.1 94993338 4066267 1801694..1801939 1 NC_008023.1 bacteriocin uviB 1801939 uviB 4066267 uviB Streptococcus pyogenes MGAS2096 bacteriocin uviB YP_601437.1 1801694 D 370565 CDS YP_601438.1 94993339 4066268 complement(1802046..1802918) 1 NC_008023.1 hypothetical protein 1802918 4066268 MGAS2096_Spy1842 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601438.1 1802046 R 370565 CDS YP_601439.1 94993340 4066269 complement(1802961..1803914) 1 NC_008023.1 hypothetical protein 1803914 4066269 MGAS2096_Spy1843 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601439.1 1802961 R 370565 CDS YP_601440.1 94993341 4066270 complement(1803859..1804800) 1 NC_008023.1 hypothetical protein 1804800 4066270 MGAS2096_Spy1844 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601440.1 1803859 R 370565 CDS YP_601441.1 94993342 4066271 complement(1804793..1806592) 1 NC_008023.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 1806592 aspS 4066271 aspS Streptococcus pyogenes MGAS2096 aspartyl-tRNA synthetase YP_601441.1 1804793 R 370565 CDS YP_601442.2 162139118 4066272 complement(1806879..1808159) 1 NC_008023.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 1808159 hisS 4066272 hisS Streptococcus pyogenes MGAS2096 histidyl-tRNA synthetase YP_601442.2 1806879 R 370565 CDS YP_601443.1 94993344 4066273 1808379..1808561 1 NC_008023.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1808561 rpmF 4066273 rpmF Streptococcus pyogenes MGAS2096 50S ribosomal protein L32 YP_601443.1 1808379 D 370565 CDS YP_601444.1 94993345 4066274 1808577..1808726 1 NC_008023.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 1808726 rpmG 4066274 rpmG Streptococcus pyogenes MGAS2096 50S ribosomal protein L33 YP_601444.1 1808577 D 370565 CDS YP_601445.1 94993346 4066275 1809007..1809633 1 NC_008023.1 cadmium resistance protein 1809633 cadD 4066275 cadD Streptococcus pyogenes MGAS2096 cadmium resistance protein YP_601445.1 1809007 D 370565 CDS YP_601446.1 94993347 4066276 1809615..1809983 1 NC_008023.1 cadmium efflux system accessory protein 1809983 cadC 4066276 cadC Streptococcus pyogenes MGAS2096 cadmium efflux system accessory protein YP_601446.1 1809615 D 370565 CDS YP_601447.1 94993348 4066277 1810013..1810957 1 NC_008023.1 hypothetical protein 1810957 4066277 MGAS2096_Spy1851 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601447.1 1810013 D 370565 CDS YP_601448.1 94993349 4066278 1811023..1811775 1 NC_008023.1 FtsK/SpoIIIE family protein 1811775 4066278 MGAS2096_Spy1852 Streptococcus pyogenes MGAS2096 FtsK/SpoIIIE family protein YP_601448.1 1811023 D 370565 CDS YP_601449.1 94993350 4064981 1811772..1812374 1 NC_008023.1 hypothetical protein 1812374 4064981 MGAS2096_Spy1853 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601449.1 1811772 D 370565 CDS YP_601450.1 94993351 4064982 complement(1812754..1813038) 1 NC_008023.1 transcriptional regulator 1813038 4064982 MGAS2096_Spy1854 Streptococcus pyogenes MGAS2096 transcriptional regulator YP_601450.1 1812754 R 370565 CDS YP_601451.1 94993352 4064983 complement(1813246..1813404) 1 NC_008023.1 hypothetical protein 1813404 4064983 MGAS2096_Spy1855 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601451.1 1813246 R 370565 CDS YP_601452.1 94993353 4064984 1813489..1814331 1 NC_008023.1 integral membrane protein 1814331 4064984 MGAS2096_Spy1856 Streptococcus pyogenes MGAS2096 integral membrane protein YP_601452.1 1813489 D 370565 CDS YP_601453.1 94993354 4064985 complement(1814378..1814800) 1 NC_008023.1 MutT/nudix family protein; phosphohydrolase 1814800 4064985 MGAS2096_Spy1857 Streptococcus pyogenes MGAS2096 phosphohydrolase YP_601453.1 1814378 R 370565 CDS YP_601454.1 94993355 4064986 complement(1814851..1815084) 1 NC_008023.1 hypothetical protein 1815084 4064986 MGAS2096_Spy1858 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601454.1 1814851 R 370565 CDS YP_601455.1 94993356 4064987 1815224..1815550 1 NC_008023.1 PadR family transcriptional regulator 1815550 4064987 MGAS2096_Spy1859 Streptococcus pyogenes MGAS2096 PadR family transcriptional regulator YP_601455.1 1815224 D 370565 CDS YP_601456.1 94993357 4064988 1815537..1816124 1 NC_008023.1 hypothetical protein 1816124 4064988 MGAS2096_Spy1860 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601456.1 1815537 D 370565 CDS YP_601457.1 94993358 4064989 1816121..1817194 1 NC_008023.1 hypothetical protein 1817194 4064989 MGAS2096_Spy1861 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601457.1 1816121 D 370565 CDS YP_601458.1 94993359 4064990 complement(1817311..1819614) 1 NC_008023.1 phage infection protein 1819614 4064990 MGAS2096_Spy1862 Streptococcus pyogenes MGAS2096 phage infection protein YP_601458.1 1817311 R 370565 CDS YP_601459.1 94993360 4064991 1819719..1820252 1 NC_008023.1 TetR family transcriptional regulator 1820252 4064991 MGAS2096_Spy1863 Streptococcus pyogenes MGAS2096 TetR family transcriptional regulator YP_601459.1 1819719 D 370565 CDS YP_601460.1 94993361 4064992 complement(1820406..1821017) 1 NC_008023.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 1821017 rpsD 4064992 rpsD Streptococcus pyogenes MGAS2096 30S ribosomal protein S4 YP_601460.1 1820406 R 370565 CDS YP_601461.1 94993362 4064993 complement(1821747..1822049) 1 NC_008023.1 hypothetical protein 1822049 4064993 MGAS2096_Spy1865 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601461.1 1821747 R 370565 CDS YP_601462.1 94993363 4064994 complement(1822036..1823412) 1 NC_008023.1 unwinds double stranded DNA; replicative DNA helicase 1823412 holB 4064994 holB Streptococcus pyogenes MGAS2096 replicative DNA helicase YP_601462.1 1822036 R 370565 CDS YP_601463.1 94993364 4064995 complement(1823433..1823885) 1 NC_008023.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 1823885 rplI 4064995 rplI Streptococcus pyogenes MGAS2096 50S ribosomal protein L9 YP_601463.1 1823433 R 370565 CDS YP_601464.1 94993365 4064996 complement(1823882..1825918) 1 NC_008023.1 phosphoesterase, DHH family protein 1825918 4064996 MGAS2096_Spy1868 Streptococcus pyogenes MGAS2096 phosphoesterase, DHH family protein YP_601464.1 1823882 R 370565 CDS YP_601465.1 94993366 4064997 complement(1825948..1827846) 1 NC_008023.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 1827846 gidA 4064997 gidA Streptococcus pyogenes MGAS2096 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA YP_601465.1 1825948 R 370565 CDS YP_601466.1 94993367 4064998 complement(1828117..1828287) 1 NC_008023.1 MutT/nudix family protein; phosphohydrolase 1828287 4064998 MGAS2096_Spy1870 Streptococcus pyogenes MGAS2096 phosphohydrolase YP_601466.1 1828117 R 370565 CDS YP_601467.1 94993368 4064999 complement(1829062..1830201) 1 NC_008023.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 1830201 mnmA 4064999 mnmA Streptococcus pyogenes MGAS2096 tRNA-specific 2-thiouridylase MnmA YP_601467.1 1829062 R 370565 CDS YP_601468.1 94993369 4065000 1830475..1831152 1 NC_008023.1 L-serine dehydratase beta subunit 1831152 sdhB 4065000 sdhB Streptococcus pyogenes MGAS2096 L-serine dehydratase beta subunit YP_601468.1 1830475 D 370565 CDS YP_601469.1 94993370 4066222 1831164..1832036 1 NC_008023.1 L-serine dehydratase alpha subunit 1832036 sdhA 4066222 sdhA Streptococcus pyogenes MGAS2096 L-serine dehydratase alpha subunit YP_601469.1 1831164 D 370565 CDS YP_601470.1 94993371 4066223 complement(1832450..1833064) 1 NC_008023.1 transglycosylase 1833064 4066223 MGAS2096_Spy1874 Streptococcus pyogenes MGAS2096 transglycosylase YP_601470.1 1832450 R 370565 CDS YP_601471.1 94993372 4066224 complement(1833436..1834236) 1 NC_008023.1 hyaluronan ABC exporter permease 1834236 cbiQ 4066224 cbiQ Streptococcus pyogenes MGAS2096 hyaluronan ABC exporter permease YP_601471.1 1833436 R 370565 CDS YP_601472.1 94993373 4066225 complement(1834229..1835071) 1 NC_008023.1 with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit 1835071 cbiO 4066225 cbiO Streptococcus pyogenes MGAS2096 cobalt transporter ATP-binding subunit YP_601472.1 1834229 R 370565 CDS YP_601473.1 94993374 4066226 complement(1835047..1835937) 1 NC_008023.1 with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit 1835937 cbiO 4066226 cbiO Streptococcus pyogenes MGAS2096 cobalt transporter ATP-binding subunit YP_601473.1 1835047 R 370565 CDS YP_601474.1 94993375 4066227 complement(1835888..1836430) 1 NC_008023.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 1836430 4066227 MGAS2096_Spy1878 Streptococcus pyogenes MGAS2096 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase YP_601474.1 1835888 R 370565 CDS YP_601475.1 94993376 4066228 complement(1836444..1837469) 1 NC_008023.1 hypothetical protein 1837469 4066228 MGAS2096_Spy1879 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601475.1 1836444 R 370565 CDS YP_601476.1 94993377 4066229 complement(1837519..1838808) 1 NC_008023.1 Zinc protease 1838808 4066229 MGAS2096_Spy1880 Streptococcus pyogenes MGAS2096 Zinc protease YP_601476.1 1837519 R 370565 CDS YP_601477.1 94993378 4066230 complement(1838810..1840054) 1 NC_008023.1 M16 family peptidase 1840054 4066230 MGAS2096_Spy1881 Streptococcus pyogenes MGAS2096 M16 family peptidase YP_601477.1 1838810 R 370565 CDS YP_601478.1 94993379 4066231 1840416..1841753 1 NC_008023.1 hyaluronan synthase 1841753 hasA 4066231 hasA Streptococcus pyogenes MGAS2096 hyaluronan synthase YP_601478.1 1840416 D 370565 CDS YP_601479.1 94993380 4066232 1841789..1842997 1 NC_008023.1 UDP-glucose 6-dehydrogenase 1842997 hasB 4066232 hasB Streptococcus pyogenes MGAS2096 UDP-glucose 6-dehydrogenase YP_601479.1 1841789 D 370565 CDS YP_601480.1 94993381 4066233 1843179..1844093 1 NC_008023.1 UTP--glucose-1-phosphate uridylyltransferase 1844093 hasC 4066233 hasC Streptococcus pyogenes MGAS2096 UTP--glucose-1-phosphate uridylyltransferase YP_601480.1 1843179 D 370565 CDS YP_601481.1 94993382 4066234 1844377..1844814 1 NC_008023.1 putative cytoplasmic protein 1844814 4066234 MGAS2096_Spy1885 Streptococcus pyogenes MGAS2096 putative cytoplasmic protein YP_601481.1 1844377 D 370565 CDS YP_601482.1 94993383 4066235 1844816..1845922 1 NC_008023.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 1845922 recF 4066235 recF Streptococcus pyogenes MGAS2096 recombination protein F YP_601482.1 1844816 D 370565 CDS YP_601483.1 94993384 4066236 complement(1845979..1846842) 1 NC_008023.1 glucose uptake family protein 1846842 4066236 MGAS2096_Spy1887 Streptococcus pyogenes MGAS2096 glucose uptake family protein YP_601483.1 1845979 R 370565 CDS YP_601484.1 94993385 4066237 complement(1847045..1848526) 1 NC_008023.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 1848526 guaB 4066237 guaB Streptococcus pyogenes MGAS2096 inosine 5'-monophosphate dehydrogenase YP_601484.1 1847045 R 370565 CDS YP_601485.2 162139117 4066238 complement(1848834..1849856) 1 NC_008023.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase II 1849856 trsA 4066238 trsA Streptococcus pyogenes MGAS2096 tryptophanyl-tRNA synthetase II YP_601485.2 1848834 R 370565 CDS YP_601486.1 94993387 4066239 complement(1849948..1850073) 1 NC_008023.1 hypothetical protein 1850073 4066239 MGAS2096_Spy1890 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601486.1 1849948 R 370565 CDS YP_601487.1 94993388 4066240 1850275..1851147 1 NC_008023.1 hypothetical protein 1851147 4066240 MGAS2096_Spy1891 Streptococcus pyogenes MGAS2096 hypothetical protein YP_601487.1 1850275 D 370565 CDS YP_601488.1 94993389 4065215 1851226..1852845 1 NC_008023.1 ABC transporter ATP-binding protein 1852845 4065215 MGAS2096_Spy1892 Streptococcus pyogenes MGAS2096 ABC transporter ATP-binding protein YP_601488.1 1851226 D 370565 CDS YP_601489.1 94993390 4065216 1852928..1855504 1 NC_008023.1 ABC transporter permease 1855504 4065216 MGAS2096_Spy1893 Streptococcus pyogenes MGAS2096 ABC transporter permease YP_601489.1 1852928 D 370565 CDS YP_601490.1 94993391 4065219 complement(1856375..1856962) 1 NC_008023.1 transposase 1856962 4065219 MGAS2096_Spy1894 Streptococcus pyogenes MGAS2096 transposase YP_601490.1 1856375 R 370565 CDS YP_601491.1 94993392 4065220 complement(1856904..1857155) 1 NC_008023.1 transposase 1857155 4065220 MGAS2096_Spy1895 Streptococcus pyogenes MGAS2096 transposase YP_601491.1 1856904 R 370565 CDS YP_601492.1 94993393 4065222 complement(1857545..1858024) 1 NC_008023.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 1858024 4065222 MGAS2096_Spy1896 Streptococcus pyogenes MGAS2096 rRNA large subunit methyltransferase YP_601492.1 1857545 R 370565 CDS YP_601493.1 94993394 4065223 1858236..1859459 1 NC_008023.1 endopeptidase degP 1859459 htrA 4065223 htrA Streptococcus pyogenes MGAS2096 endopeptidase degP YP_601493.1 1858236 D 370565 CDS YP_601494.1 94993395 4065224 1859518..1860324 1 NC_008023.1 chromosome partitioning protein parB 1860324 parB 4065224 parB Streptococcus pyogenes MGAS2096 chromosome partitioning protein parB YP_601494.1 1859518 D 370565 CDS