-- dump date 20120504_162930 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 370565000001 SEQ_END SEQ_END NC_008023.1 1860355 1860355 DR NC_008023.1; contig end 1860355..1860355 Streptococcus pyogenes MGAS2096 YP_599597.1 CDS dnaA NC_008023.1 202 1557 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 202..1557 Streptococcus pyogenes MGAS2096 4064499 YP_599598.1 CDS dnaN NC_008023.1 1712 2848 D binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 1712..2848 Streptococcus pyogenes MGAS2096 4064500 YP_599599.1 CDS MGAS2096_Spy0003 NC_008023.1 2923 3120 D putative cytoplasmic protein 2923..3120 Streptococcus pyogenes MGAS2096 4064501 YP_599600.1 CDS MGAS2096_Spy0004 NC_008023.1 3450 4565 D translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 3450..4565 Streptococcus pyogenes MGAS2096 4066442 YP_599601.1 CDS pth NC_008023.1 4590 5204 D Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 4590..5204 Streptococcus pyogenes MGAS2096 4066443 YP_599602.1 CDS trcF NC_008023.1 5207 8710 D transcription-repair coupling factor 5207..8710 Streptococcus pyogenes MGAS2096 4066444 YP_599603.1 CDS MGAS2096_Spy0007 NC_008023.1 8872 9144 D heat shock protein 15 8872..9144 Streptococcus pyogenes MGAS2096 4066445 YP_599604.1 CDS divIC NC_008023.1 9131 9502 D cell division protein DIVIC 9131..9502 Streptococcus pyogenes MGAS2096 4066446 YP_599605.1 CDS MGAS2096_Spy0009 NC_008023.1 9499 9624 D hypothetical protein 9499..9624 Streptococcus pyogenes MGAS2096 4066447 YP_599606.1 CDS MGAS2096_Spy0010 NC_008023.1 9637 10923 D Beta-lactamase 9637..10923 Streptococcus pyogenes MGAS2096 4066448 YP_599607.1 CDS tilS NC_008023.1 10920 12206 D tRNA(Ile)-lysidine synthetase TilS 10920..12206 Streptococcus pyogenes MGAS2096 4066449 YP_599608.1 CDS MGAS2096_Spy0012 NC_008023.1 12211 12753 D hypoxanthine-guanine phosphoribosyltransferase 12211..12753 Streptococcus pyogenes MGAS2096 4066450 YP_599609.1 CDS MGAS2096_Spy0013 NC_008023.1 12775 13155 D cell division protein ftsH 12775..13155 Streptococcus pyogenes MGAS2096 4066451 YP_599610.1 CDS ftsH NC_008023.1 13133 14755 D cell division protein ftsH 13133..14755 Streptococcus pyogenes MGAS2096 4066452 YP_599611.1 CDS MGAS2096_Spy0015 NC_008023.1 15013 16473 D amino acid permease 15013..16473 Streptococcus pyogenes MGAS2096 4066453 YP_599612.1 CDS MGAS2096_Spy0016 NC_008023.1 16815 16949 R hypothetical protein complement(16815..16949) Streptococcus pyogenes MGAS2096 4066454 YP_599613.1 CDS MGAS2096_Spy0017 NC_008023.1 30142 30348 R transposase complement(30142..30348) Streptococcus pyogenes MGAS2096 4065245 YP_599614.1 CDS sibA NC_008023.1 30845 32041 D hypothetical protein 30845..32041 Streptococcus pyogenes MGAS2096 4065246 YP_599615.1 CDS prsA2 NC_008023.1 32282 33256 D catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 32282..33256 Streptococcus pyogenes MGAS2096 4065247 YP_599616.1 CDS recO NC_008023.1 33442 34197 D involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 33442..34197 Streptococcus pyogenes MGAS2096 4065248 YP_599617.1 CDS plsX NC_008023.1 34222 35307 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; putative glycerol-3-phosphate acyltransferase PlsX 34222..35307 Streptococcus pyogenes MGAS2096 4065249 YP_599618.1 CDS acpP2 NC_008023.1 35300 35542 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 35300..35542 Streptococcus pyogenes MGAS2096 4065250 YP_599619.1 CDS MGAS2096_Spy0023 NC_008023.1 35663 36397 D catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 35663..36397 Streptococcus pyogenes MGAS2096 4065251 YP_599620.1 CDS MGAS2096_Spy0024 NC_008023.1 36473 40246 D phosphoribosylformylglycinamidine synthase 36473..40246 Streptococcus pyogenes MGAS2096 4065252 YP_599621.1 CDS purF NC_008023.1 40350 41861 D Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 40350..41861 Streptococcus pyogenes MGAS2096 4065253 YP_599622.1 CDS purM NC_008023.1 41889 42911 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 41889..42911 Streptococcus pyogenes MGAS2096 4065254 YP_599623.1 CDS purN NC_008023.1 43079 43633 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 43079..43633 Streptococcus pyogenes MGAS2096 4065255 YP_599624.1 CDS purH NC_008023.1 43817 45364 D involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 43817..45364 Streptococcus pyogenes MGAS2096 4065256 YP_599625.1 CDS MGAS2096_Spy0029 NC_008023.1 45422 46546 R autolysin complement(45422..46546) Streptococcus pyogenes MGAS2096 4065257 YP_599626.1 CDS purD NC_008023.1 46652 48064 D catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 46652..48064 Streptococcus pyogenes MGAS2096 4065258 YP_599627.1 CDS purE NC_008023.1 48342 48833 D phosphoribosylaminoimidazole carboxylase catalytic subunit 48342..48833 Streptococcus pyogenes MGAS2096 4065259 YP_599628.1 CDS purK NC_008023.1 48784 49893 D With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 48784..49893 Streptococcus pyogenes MGAS2096 4065260 YP_599629.1 CDS MGAS2096_Spy0033 NC_008023.1 49914 51254 D putative cytoplasmic protein 49914..51254 Streptococcus pyogenes MGAS2096 4065261 YP_599630.1 CDS MGAS2096_Spy0034 NC_008023.1 51255 51413 R hypothetical protein complement(51255..51413) Streptococcus pyogenes MGAS2096 4065262 YP_599631.1 CDS purB NC_008023.1 51623 52915 D Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 51623..52915 Streptococcus pyogenes MGAS2096 4065263 YP_599632.1 CDS MGAS2096_Spy0036 NC_008023.1 53048 53959 D transcriptional regulator 53048..53959 Streptococcus pyogenes MGAS2096 4066203 YP_599633.1 CDS ruvB NC_008023.1 54113 55183 D promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 54113..55183 Streptococcus pyogenes MGAS2096 4066204 YP_599634.1 CDS MGAS2096_Spy0038 NC_008023.1 55321 55758 D protein tyrosine phosphatase 55321..55758 Streptococcus pyogenes MGAS2096 4066205 YP_599635.1 CDS MGAS2096_Spy0039 NC_008023.1 55782 56183 D hypothetical protein 55782..56183 Streptococcus pyogenes MGAS2096 4066206 YP_599636.1 CDS MGAS2096_Spy0040 NC_008023.1 56180 57955 D acyltransferase 56180..57955 Streptococcus pyogenes MGAS2096 4066207 YP_599637.1 CDS MGAS2096_Spy0041 NC_008023.1 58265 60907 D bifunctional; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 58265..60907 Streptococcus pyogenes MGAS2096 4066208 YP_599638.1 CDS adhA NC_008023.1 61102 61566 D alcohol dehydrogenase 61102..61566 Streptococcus pyogenes MGAS2096 4066209 YP_599639.1 CDS MGAS2096_Spy0043 NC_008023.1 61735 62028 D alcohol dehydrogenase 61735..62028 Streptococcus pyogenes MGAS2096 4066210 YP_599640.1 CDS MGAS2096_Spy0044 NC_008023.1 61958 62176 D alcohol dehydrogenase 61958..62176 Streptococcus pyogenes MGAS2096 4066211 YP_599641.1 CDS MGAS2096_Spy0045 NC_008023.1 62564 63853 D Na+ driven multidrug efflux pump 62564..63853 Streptococcus pyogenes MGAS2096 4066212 YP_599642.1 CDS rpsJ NC_008023.1 64052 64360 D NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 64052..64360 Streptococcus pyogenes MGAS2096 4066213 YP_599643.1 CDS rplC NC_008023.1 64608 65234 D binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 64608..65234 Streptococcus pyogenes MGAS2096 4066214 YP_599644.1 CDS MGAS2096_Spy0048 NC_008023.1 65258 65587 D 50S ribosomal protein L1E (L4P) 65258..65587 Streptococcus pyogenes MGAS2096 4066215 YP_599645.1 CDS rplD NC_008023.1 65584 65880 D 50S ribosomal protein L1E (L4P) 65584..65880 Streptococcus pyogenes MGAS2096 4066216 YP_599646.1 CDS rplW NC_008023.1 65880 66176 D binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 65880..66176 Streptococcus pyogenes MGAS2096 4066217 YP_599647.1 CDS rplB NC_008023.1 66194 67027 D one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 66194..67027 Streptococcus pyogenes MGAS2096 4066218 YP_599648.2 CDS rpsS NC_008023.1 67167 67445 D protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 67167..67445 Streptococcus pyogenes MGAS2096 4066219 YP_599649.1 CDS rplV NC_008023.1 67461 67805 D binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 67461..67805 Streptococcus pyogenes MGAS2096 4066220 YP_599650.1 CDS rpsC NC_008023.1 67818 68471 D forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 67818..68471 Streptococcus pyogenes MGAS2096 4066221 YP_599651.1 CDS rplP NC_008023.1 68475 68888 D located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 68475..68888 Streptococcus pyogenes MGAS2096 4064883 YP_599652.1 CDS rpmC NC_008023.1 68898 69104 D one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 68898..69104 Streptococcus pyogenes MGAS2096 4064884 YP_599653.1 CDS rpsQ NC_008023.1 69130 69390 D primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 69130..69390 Streptococcus pyogenes MGAS2096 4064885 YP_599654.1 CDS rplN NC_008023.1 69415 69783 D binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 69415..69783 Streptococcus pyogenes MGAS2096 4064886 YP_599655.1 CDS rplX NC_008023.1 69865 70170 D assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 69865..70170 Streptococcus pyogenes MGAS2096 4064887 YP_599656.1 CDS rplE NC_008023.1 70194 70736 D part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 70194..70736 Streptococcus pyogenes MGAS2096 4064888 YP_599657.1 CDS rpsH NC_008023.1 71087 71485 D binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 71087..71485 Streptococcus pyogenes MGAS2096 4064889 YP_599658.1 CDS rplF NC_008023.1 71688 72224 D ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 71688..72224 Streptococcus pyogenes MGAS2096 4064890 YP_599659.1 CDS rplR NC_008023.1 72320 72685 D binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 72320..72685 Streptococcus pyogenes MGAS2096 4064891 YP_599660.1 CDS rpsE NC_008023.1 72704 73198 D located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 72704..73198 Streptococcus pyogenes MGAS2096 4064892 YP_599661.1 CDS rpmD NC_008023.1 73213 73395 D L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 73213..73395 Streptococcus pyogenes MGAS2096 4064893 YP_599662.1 CDS rplO NC_008023.1 73610 74050 D late assembly protein; 50S ribosomal protein L15 73610..74050 Streptococcus pyogenes MGAS2096 4064894 YP_599663.2 CDS secY NC_008023.1 74067 75371 D forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 74067..75371 Streptococcus pyogenes MGAS2096 4064895 YP_599664.1 CDS adk NC_008023.1 75521 76159 D essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 75521..76159 Streptococcus pyogenes MGAS2096 4064896 YP_599665.1 CDS infA NC_008023.1 76223 76495 D stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 76223..76495 Streptococcus pyogenes MGAS2096 4064897 YP_599666.1 CDS rpmJ NC_008023.1 76521 76637 D smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 76521..76637 Streptococcus pyogenes MGAS2096 4064898 YP_599667.1 CDS rpsM NC_008023.1 76655 77020 D located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 76655..77020 Streptococcus pyogenes MGAS2096 4064899 YP_599668.1 CDS rpsK NC_008023.1 77038 77421 D located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 77038..77421 Streptococcus pyogenes MGAS2096 4064900 YP_599669.1 CDS rpoA NC_008023.1 77467 78405 D catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 77467..78405 Streptococcus pyogenes MGAS2096 4064901 YP_599670.1 CDS rplQ NC_008023.1 78420 78806 D is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 78420..78806 Streptococcus pyogenes MGAS2096 4064902 YP_599671.1 CDS MGAS2096_Spy0075 NC_008023.1 79402 79536 R hypothetical protein complement(79402..79536) Streptococcus pyogenes MGAS2096 4065332 YP_599672.1 CDS MGAS2096_Spy0076 NC_008023.1 86048 86233 D hypothetical protein 86048..86233 Streptococcus pyogenes MGAS2096 4066371 YP_599673.1 CDS MGAS2096_Spy0077 NC_008023.1 86737 86841 D 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 86737..86841 Streptococcus pyogenes MGAS2096 4066372 YP_599674.1 CDS MGAS2096_Spy0078 NC_008023.1 86872 87180 D 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 86872..87180 Streptococcus pyogenes MGAS2096 4066373 YP_599675.1 CDS MGAS2096_Spy0079 NC_008023.1 87220 87447 D 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 87220..87447 Streptococcus pyogenes MGAS2096 4066374 YP_599676.1 CDS adcR NC_008023.1 87557 88000 D MarR family transcriptional regulator 87557..88000 Streptococcus pyogenes MGAS2096 4066375 YP_599677.1 CDS adcC NC_008023.1 88004 88723 D high-affinity zinc uptake system ATP-binding protein znuC 88004..88723 Streptococcus pyogenes MGAS2096 4066376 YP_599678.1 CDS adcB NC_008023.1 88677 89531 D high-affinity zinc uptake system membrane protein znuB 88677..89531 Streptococcus pyogenes MGAS2096 4066377 YP_599679.1 CDS MGAS2096_Spy0083 NC_008023.1 89571 89954 R bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) complement(89571..89954) Streptococcus pyogenes MGAS2096 4065479 YP_599680.1 CDS tyrS NC_008023.1 90006 91262 R catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase complement(90006..91262) Streptococcus pyogenes MGAS2096 4065480 YP_599681.1 CDS pbp1b NC_008023.1 91354 93666 D multimodular transpeptidase-transglycosylase PBP 1B 91354..93666 Streptococcus pyogenes MGAS2096 4065481 YP_599682.1 CDS rpoB NC_008023.1 93930 97496 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 93930..97496 Streptococcus pyogenes MGAS2096 4065482 YP_599683.1 CDS rpoC NC_008023.1 97587 101210 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 97587..101210 Streptococcus pyogenes MGAS2096 4065483 YP_599684.1 CDS MGAS2096_Spy0088 NC_008023.1 101362 101727 D putative DNA binding protein 101362..101727 Streptococcus pyogenes MGAS2096 4065484 YP_599685.1 CDS comYA NC_008023.1 101820 102758 D ComG operon protein 1 101820..102758 Streptococcus pyogenes MGAS2096 4065485 YP_599686.1 CDS comYB NC_008023.1 102637 103728 D ComG operon protein 2 102637..103728 Streptococcus pyogenes MGAS2096 4065486 YP_599687.1 CDS comYC NC_008023.1 103730 104056 D ComG operon protein 3 103730..104056 Streptococcus pyogenes MGAS2096 4065487 YP_599688.1 CDS MGAS2096_Spy0092 NC_008023.1 104031 104459 D ComG operon protein 4 104031..104459 Streptococcus pyogenes MGAS2096 4065488 YP_599689.1 CDS MGAS2096_Spy0093 NC_008023.1 104416 104700 D hypothetical protein 104416..104700 Streptococcus pyogenes MGAS2096 4065489 YP_599690.1 CDS comYD NC_008023.1 104693 105127 D ComG operon protein 6 104693..105127 Streptococcus pyogenes MGAS2096 4065490 YP_599691.1 CDS MGAS2096_Spy0095 NC_008023.1 105111 105437 D ComG operon protein 6 105111..105437 Streptococcus pyogenes MGAS2096 4065491 YP_599692.1 CDS MGAS2096_Spy0096 NC_008023.1 105490 106488 D adenine-specific methyltransferase 105490..106488 Streptococcus pyogenes MGAS2096 4065492 YP_599693.1 CDS ackA NC_008023.1 106547 107743 D AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 106547..107743 Streptococcus pyogenes MGAS2096 4065493 YP_599694.1 CDS MGAS2096_Spy0098 NC_008023.1 107930 108238 D hypothetical protein 107930..108238 Streptococcus pyogenes MGAS2096 4065494 YP_599695.1 CDS proC NC_008023.1 108321 109091 R catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase complement(108321..109091) Streptococcus pyogenes MGAS2096 4065495 YP_599696.1 CDS pepA NC_008023.1 109139 110206 R glutamyl aminopeptidase complement(109139..110206) Streptococcus pyogenes MGAS2096 4065496 YP_599697.1 CDS MGAS2096_Spy0101 NC_008023.1 110316 110480 R hypothetical protein complement(110316..110480) Streptococcus pyogenes MGAS2096 4065497 YP_599698.1 CDS MGAS2096_Spy0102 NC_008023.1 110662 110952 D hypothetical protein 110662..110952 Streptococcus pyogenes MGAS2096 4065498 YP_599699.1 CDS MGAS2096_Spy0103 NC_008023.1 110949 111269 D thioredoxin 110949..111269 Streptococcus pyogenes MGAS2096 4065499 YP_599700.1 CDS MGAS2096_Spy0104 NC_008023.1 111287 111913 D tRNA-binding domain-containing protein 111287..111913 Streptococcus pyogenes MGAS2096 4065500 YP_599701.1 CDS MGAS2096_Spy0105 NC_008023.1 112065 112460 D binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 112065..112460 Streptococcus pyogenes MGAS2096 4065501 YP_599702.1 CDS MGAS2096_Spy0106 NC_008023.1 112720 113409 R bifunctional; deoxyadenosine kinase / deoxyguanosine kinase complement(112720..113409) Streptococcus pyogenes MGAS2096 4065502 YP_599703.1 CDS MGAS2096_Spy0107 NC_008023.1 113381 114430 R tRNA-dihydrouridine synthase complement(113381..114430) Streptococcus pyogenes MGAS2096 4065503 YP_599704.1 CDS hslO NC_008023.1 114345 115217 R becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin complement(114345..115217) Streptococcus pyogenes MGAS2096 4065504 YP_599705.1 CDS rofA NC_008023.1 115364 116956 R transcriptional regulator RofA complement(115364..116956) Streptococcus pyogenes MGAS2096 4065505 YP_599706.1 CDS MGAS2096_Spy0110 NC_008023.1 117089 119185 D fibronectin-binding protein 117089..119185 Streptococcus pyogenes MGAS2096 4065506 YP_599707.1 CDS MGAS2096_Spy0111 NC_008023.1 119409 119714 D sortase 119409..119714 Streptococcus pyogenes MGAS2096 4065507 YP_599708.1 CDS MGAS2096_Spy0112 NC_008023.1 119721 120257 D sortase 119721..120257 Streptococcus pyogenes MGAS2096 4065508 YP_599709.1 CDS MGAS2096_Spy0113 NC_008023.1 120543 122813 D fibronectin-binding protein 120543..122813 Streptococcus pyogenes MGAS2096 4065509 YP_599710.1 CDS MGAS2096_Spy0114 NC_008023.1 122806 123327 D Signal peptidase I 122806..123327 Streptococcus pyogenes MGAS2096 4065510 YP_599711.1 CDS MGAS2096_Spy0115 NC_008023.1 123334 124377 D fibronectin-binding protein 123334..124377 Streptococcus pyogenes MGAS2096 4065511 YP_599712.1 CDS eftLSL-B NC_008023.1 124378 125118 D sortase 124378..125118 Streptococcus pyogenes MGAS2096 4065512 YP_599713.1 CDS MGAS2096_Spy0117 NC_008023.1 125063 125722 D hypothetical protein 125063..125722 Streptococcus pyogenes MGAS2096 4065513 YP_599714.1 CDS MGAS2096_Spy0118 NC_008023.1 125881 127086 R AraC family transcriptional regulator complement(125881..127086) Streptococcus pyogenes MGAS2096 4065514 YP_599715.1 CDS MGAS2096_Spy0119 NC_008023.1 127471 130956 D collagen adhesion protein 127471..130956 Streptococcus pyogenes MGAS2096 4065515 YP_599716.1 CDS MGAS2096_Spy0120 NC_008023.1 131223 131888 R hypothetical protein complement(131223..131888) Streptococcus pyogenes MGAS2096 4065516 YP_599717.1 CDS atoE NC_008023.1 132208 133647 D Short-chain fatty acids transporter 132208..133647 Streptococcus pyogenes MGAS2096 4065517 YP_599718.1 CDS MGAS2096_Spy0122 NC_008023.1 133715 134626 R LysR family transcriptional regulator complement(133715..134626) Streptococcus pyogenes MGAS2096 4065634 YP_599719.1 CDS MGAS2096_Spy0123 NC_008023.1 134747 135931 D Acetyl-CoA acetyltransferase 134747..135931 Streptococcus pyogenes MGAS2096 4065635 YP_599720.1 CDS atoD2 NC_008023.1 135886 136602 D acetate CoA-transferase subunit alpha 135886..136602 Streptococcus pyogenes MGAS2096 4065636 YP_599721.1 CDS MGAS2096_Spy0125 NC_008023.1 136605 137252 D acetate CoA-transferase subunit beta 136605..137252 Streptococcus pyogenes MGAS2096 4065637 YP_599722.1 CDS MGAS2096_Spy0126 NC_008023.1 137232 137390 R hypothetical protein complement(137232..137390) Streptococcus pyogenes MGAS2096 4065638 YP_599723.1 CDS MGAS2096_Spy0127 NC_008023.1 137374 138054 R putative DNA-binding protein complement(137374..138054) Streptococcus pyogenes MGAS2096 4065639 YP_599724.1 CDS MGAS2096_Spy0128 NC_008023.1 138228 138593 D translation initiation inhibitor 138228..138593 Streptococcus pyogenes MGAS2096 4065640 YP_599725.1 CDS sloR NC_008023.1 138630 139649 D transcriptional regulator pfoR 138630..139649 Streptococcus pyogenes MGAS2096 4065641 YP_599726.1 CDS MGAS2096_Spy0130 NC_008023.1 140100 140423 D hypothetical protein 140100..140423 Streptococcus pyogenes MGAS2096 4065642 YP_599727.1 CDS ntpI NC_008023.1 140413 142413 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I is part of the membrane proton channel.; V-type ATP synthase subunit I 140413..142413 Streptococcus pyogenes MGAS2096 4065643 YP_599728.2 CDS ntpK NC_008023.1 142415 142894 D produces ATP from ADP in the presence of a proton gradient across the membrane; the K subunit is a nonenzymatic component which binds the dimeric form by interacting with the G and E subunits; V-type ATP synthase subunit K 142415..142894 Streptococcus pyogenes MGAS2096 4065644 YP_599729.1 CDS ntpE NC_008023.1 142963 143547 D V-type sodium ATP synthase subunit E 142963..143547 Streptococcus pyogenes MGAS2096 4065645 YP_599730.1 CDS ntpC NC_008023.1 143563 144561 D V-type sodium ATP synthase subunit C 143563..144561 Streptococcus pyogenes MGAS2096 4065646 YP_599731.1 CDS ntpF NC_008023.1 144558 144878 D produces ATP from ADP in the presence of a proton gradient across the membrane; the F subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit F 144558..144878 Streptococcus pyogenes MGAS2096 4065647 YP_599732.1 CDS ntpA NC_008023.1 145079 146854 D produces ATP from ADP in the presence of a proton gradient across the membrane; the A subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit A 145079..146854 Streptococcus pyogenes MGAS2096 4065648 YP_599733.1 CDS ntpB NC_008023.1 146855 148270 D produces ATP from ADP in the presence of a proton gradient across the membrane; the B subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit B 146855..148270 Streptococcus pyogenes MGAS2096 4065649 YP_599734.1 CDS ntpD NC_008023.1 148294 148941 D produces ATP from ADP in the presence of a proton gradient across the membrane; the D subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit D 148294..148941 Streptococcus pyogenes MGAS2096 4065650 YP_599735.1 CDS MGAS2096_Spy0139 NC_008023.1 149061 150323 R tellurite resistance protein complement(149061..150323) Streptococcus pyogenes MGAS2096 4065651 YP_599736.1 CDS MGAS2096_Spy0140 NC_008023.1 150336 151214 R hypothetical protein complement(150336..151214) Streptococcus pyogenes MGAS2096 4065652 YP_599737.1 CDS MGAS2096_Spy0141 NC_008023.1 151652 151936 D adenylosuccinate synthetase 151652..151936 Streptococcus pyogenes MGAS2096 4065653 YP_599738.1 CDS purA NC_008023.1 152061 152945 D adenylosuccinate synthetase 152061..152945 Streptococcus pyogenes MGAS2096 4065654 YP_599739.1 CDS MGAS2096_Spy0143 NC_008023.1 153272 154315 D nucleoside-binding protein 153272..154315 Streptococcus pyogenes MGAS2096 4065655 YP_599740.1 CDS MGAS2096_Spy0144 NC_008023.1 154341 154454 R hypothetical protein complement(154341..154454) Streptococcus pyogenes MGAS2096 4065656 YP_599741.1 CDS nusG NC_008023.1 154473 155027 D Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 154473..155027 Streptococcus pyogenes MGAS2096 4065657 YP_599742.1 CDS nga NC_008023.1 155389 156753 D NAD glycohydrolase 155389..156753 Streptococcus pyogenes MGAS2096 4065658 YP_599743.1 CDS ifs NC_008023.1 156758 157243 D hypothetical protein 156758..157243 Streptococcus pyogenes MGAS2096 4065659 YP_599744.1 CDS slo NC_008023.1 157258 158982 D streptolysin O 157258..158982 Streptococcus pyogenes MGAS2096 4065660 YP_599745.1 CDS MGAS2096_Spy0149 NC_008023.1 159237 159668 D hypothetical protein 159237..159668 Streptococcus pyogenes MGAS2096 4065661 YP_599746.1 CDS MGAS2096_Spy0150 NC_008023.1 160500 160667 R hypothetical protein complement(160500..160667) Streptococcus pyogenes MGAS2096 4065662 YP_599747.1 CDS MGAS2096_Spy0151 NC_008023.1 160842 161048 R hypothetical protein complement(160842..161048) Streptococcus pyogenes MGAS2096 4065663 YP_599748.1 CDS metB NC_008023.1 161480 162448 D cystathionine beta-lyase 161480..162448 Streptococcus pyogenes MGAS2096 4065664 YP_599749.1 CDS MGAS2096_Spy0153 NC_008023.1 162527 162763 D cystathionine beta-lyase 162527..162763 Streptococcus pyogenes MGAS2096 4065665 YP_599750.1 CDS leuS NC_008023.1 162974 165475 D leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 162974..165475 Streptococcus pyogenes MGAS2096 4065666 YP_599751.1 CDS MGAS2096_Spy0155 NC_008023.1 165838 166701 D transposase 165838..166701 Streptococcus pyogenes MGAS2096 4065667 YP_599752.1 CDS ulaA NC_008023.1 166750 168183 D membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 166750..168183 Streptococcus pyogenes MGAS2096 4065668 YP_599753.1 CDS MGAS2096_Spy0157 NC_008023.1 168254 168532 D PTS system 3-keto-L-gulonate specific transporter subunit IIB 168254..168532 Streptococcus pyogenes MGAS2096 4065669 YP_599754.1 CDS MGAS2096_Spy0158 NC_008023.1 168655 169140 D PTS system 3-keto-L-gulonate specific transporter subunit IIA 168655..169140 Streptococcus pyogenes MGAS2096 4065670 YP_599755.1 CDS ulaD NC_008023.1 169231 169893 D catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 169231..169893 Streptococcus pyogenes MGAS2096 4065671 YP_599756.1 CDS MGAS2096_Spy0160 NC_008023.1 169856 170761 D L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; putative L-xylulose 5-phosphate 3-epimerase 169856..170761 Streptococcus pyogenes MGAS2096 4065672 YP_599757.1 CDS araD NC_008023.1 170739 171467 D catalyzes the formation of D-xylulose 5-phosphate from L-ribulose 5-phosphate in the L-arabinose and L-ascorbate degradation pathways; L-ribulose-5-phosphate 4-epimerase 170739..171467 Streptococcus pyogenes MGAS2096 4065790 YP_599758.1 CDS MGAS2096_Spy0162 NC_008023.1 171525 171671 D hypothetical protein 171525..171671 Streptococcus pyogenes MGAS2096 4065791 YP_599759.1 CDS MGAS2096_Spy0163 NC_008023.1 171792 173438 D BigG family transcription antiterminator 171792..173438 Streptococcus pyogenes MGAS2096 4065792 YP_599760.1 CDS MGAS2096_Spy0164 NC_008023.1 173691 174782 D putative L-ascorbate 6-phosphate lactonase 173691..174782 Streptococcus pyogenes MGAS2096 4065793 YP_599761.1 CDS MGAS2096_Spy0165 NC_008023.1 175270 175491 D glycine betaine transport ATP-binding protein 175270..175491 Streptococcus pyogenes MGAS2096 4065794 YP_599762.1 CDS MGAS2096_Spy0166 NC_008023.1 175485 175733 D glycine betaine transport ATP-binding protein 175485..175733 Streptococcus pyogenes MGAS2096 4065795 YP_599763.1 CDS opuAA NC_008023.1 175637 176464 D glycine betaine transport ATP-binding protein 175637..176464 Streptococcus pyogenes MGAS2096 4065796 YP_599764.1 CDS opuABC NC_008023.1 176480 177499 D glycine betaine-binding protein / glycine betaine transport system permease 176480..177499 Streptococcus pyogenes MGAS2096 4065797 YP_599765.1 CDS MGAS2096_Spy0169 NC_008023.1 177463 178206 D glycine betaine-binding protein / glycine betaine transport system permease 177463..178206 Streptococcus pyogenes MGAS2096 4065798 YP_599766.1 CDS polA NC_008023.1 178558 180978 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 178558..180978 Streptococcus pyogenes MGAS2096 4065799 YP_599767.1 CDS MGAS2096_Spy0171 NC_008023.1 181165 181620 D CoA binding protein 181165..181620 Streptococcus pyogenes MGAS2096 4065800 YP_599768.1 CDS perR NC_008023.1 181672 182139 D ferric uptake regulation protein 181672..182139 Streptococcus pyogenes MGAS2096 4065801 YP_599769.1 CDS vlg NC_008023.1 182296 182595 D transcriptional regulatory protein 182296..182595 Streptococcus pyogenes MGAS2096 4065802 YP_599770.1 CDS MGAS2096_Spy0174 NC_008023.1 182817 184151 D Co-activator of prophage gene expression IbrA 182817..184151 Streptococcus pyogenes MGAS2096 4065803 YP_599771.1 CDS MGAS2096_Spy0175 NC_008023.1 184144 184674 D Co-activator of prophage gene expression IbrB 184144..184674 Streptococcus pyogenes MGAS2096 4065804 YP_599772.1 CDS MGAS2096_Spy0176 NC_008023.1 184721 184963 R transposase complement(184721..184963) Streptococcus pyogenes MGAS2096 4065805 YP_599773.1 CDS MGAS2096_Spy0177 NC_008023.1 185003 185218 R transposase complement(185003..185218) Streptococcus pyogenes MGAS2096 4065806 YP_599774.1 CDS MGAS2096_Spy0178 NC_008023.1 185215 185826 R transposase complement(185215..185826) Streptococcus pyogenes MGAS2096 4065807 YP_599775.1 CDS MGAS2096_Spy0179 NC_008023.1 185859 186074 R transposase complement(185859..186074) Streptococcus pyogenes MGAS2096 4065808 YP_599776.1 CDS MGAS2096_Spy0180 NC_008023.1 186230 187540 R transporter complement(186230..187540) Streptococcus pyogenes MGAS2096 4066422 YP_599777.1 CDS nadC NC_008023.1 187737 188636 D catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase 187737..188636 Streptococcus pyogenes MGAS2096 4066423 YP_599778.1 CDS MGAS2096_Spy0182 NC_008023.1 188936 189742 R transposase complement(188936..189742) Streptococcus pyogenes MGAS2096 4066424 YP_599779.1 CDS MGAS2096_Spy0183 NC_008023.1 189763 190296 R transposase complement(189763..190296) Streptococcus pyogenes MGAS2096 4066425 YP_599780.1 CDS MGAS2096_Spy0184 NC_008023.1 190364 191227 R integral membrane protein complement(190364..191227) Streptococcus pyogenes MGAS2096 4066426 YP_599781.1 CDS MGAS2096_Spy0185 NC_008023.1 191264 191449 D hypothetical protein 191264..191449 Streptococcus pyogenes MGAS2096 4066427 YP_599782.1 CDS tgt NC_008023.1 191446 192588 D Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 191446..192588 Streptococcus pyogenes MGAS2096 4066428 YP_599783.1 CDS MGAS2096_Spy0187 NC_008023.1 192806 193117 D Zinc finger protein 192806..193117 Streptococcus pyogenes MGAS2096 4066429 YP_599784.1 CDS MGAS2096_Spy0188 NC_008023.1 193121 193660 D BioY protein 193121..193660 Streptococcus pyogenes MGAS2096 4066430 YP_599785.1 CDS MGAS2096_Spy0189 NC_008023.1 193819 194961 D transposase 193819..194961 Streptococcus pyogenes MGAS2096 4066431 YP_599786.1 CDS MGAS2096_Spy0190 NC_008023.1 194945 195076 D hypothetical protein 194945..195076 Streptococcus pyogenes MGAS2096 4066432 YP_599787.1 CDS MGAS2096_Spy0191 NC_008023.1 195126 195905 D metal-dependent hydrolase 195126..195905 Streptococcus pyogenes MGAS2096 4066433 YP_599788.1 CDS MGAS2096_Spy0192 NC_008023.1 195881 196420 D tRNA-specific adenosine deaminase 195881..196420 Streptococcus pyogenes MGAS2096 4066434 YP_599789.1 CDS MGAS2096_Spy0193 NC_008023.1 197034 198266 R S-layer protein / peptidoglycan endo-beta-N-acetylglucosaminidase complement(197034..198266) Streptococcus pyogenes MGAS2096 4066435 YP_599790.1 CDS MGAS2096_Spy0194 NC_008023.1 198308 198415 D putative cytoplasmic protein 198308..198415 Streptococcus pyogenes MGAS2096 4066436 YP_599791.1 CDS speG NC_008023.1 198666 199370 D enterotoxin 198666..199370 Streptococcus pyogenes MGAS2096 4066437 YP_599792.1 CDS MGAS2096_Spy0196 NC_008023.1 199458 199577 D hypothetical protein 199458..199577 Streptococcus pyogenes MGAS2096 4066438 YP_599793.1 CDS MGAS2096_Spy0197 NC_008023.1 199613 199732 D putative cytoplasmic protein 199613..199732 Streptococcus pyogenes MGAS2096 4066439 YP_599794.1 CDS pgi NC_008023.1 199829 201178 D functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 199829..201178 Streptococcus pyogenes MGAS2096 4066440 YP_599795.1 CDS MGAS2096_Spy0199 NC_008023.1 201527 203035 R transcriptional regulator complement(201527..203035) Streptococcus pyogenes MGAS2096 4066441 YP_599796.1 CDS MGAS2096_Spy0200 NC_008023.1 203581 204384 D transposase 203581..204384 Streptococcus pyogenes MGAS2096 4064943 YP_599797.1 CDS MGAS2096_Spy0201 NC_008023.1 204381 204722 D transposase 204381..204722 Streptococcus pyogenes MGAS2096 4064944 YP_599798.1 CDS MGAS2096_Spy0202 NC_008023.1 204706 204831 D hypothetical protein 204706..204831 Streptococcus pyogenes MGAS2096 4064945 YP_599799.1 CDS MGAS2096_Spy0203 NC_008023.1 204912 205019 D putative cytoplasmic protein 204912..205019 Streptococcus pyogenes MGAS2096 4064946 YP_599800.1 CDS MGAS2096_Spy0204 NC_008023.1 205047 205718 D Rhomboid family; integral membrane protein 205047..205718 Streptococcus pyogenes MGAS2096 4064947 YP_599801.1 CDS hasC2 NC_008023.1 205817 206722 R UTP--glucose-1-phosphate uridylyltransferase complement(205817..206722) Streptococcus pyogenes MGAS2096 4064948 YP_599802.1 CDS gpsA NC_008023.1 206749 207765 R catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase complement(206749..207765) Streptococcus pyogenes MGAS2096 4064949 YP_599803.1 CDS MGAS2096_Spy0207 NC_008023.1 208063 208512 D MarR family transcriptional regulator 208063..208512 Streptococcus pyogenes MGAS2096 4064950 YP_599804.1 CDS MGAS2096_Spy0208 NC_008023.1 208505 210211 D multidrug ABC transporter permease/ATP-binding protein 208505..210211 Streptococcus pyogenes MGAS2096 4064951 YP_599805.1 CDS MGAS2096_Spy0209 NC_008023.1 210211 211998 D multidrug/protein/lipid ABC transporter family ATP-binding and permease 210211..211998 Streptococcus pyogenes MGAS2096 4064952 YP_599806.1 CDS MGAS2096_Spy0210 NC_008023.1 212116 212883 D putative cytoplasmic protein 212116..212883 Streptococcus pyogenes MGAS2096 4064953 YP_599807.1 CDS MGAS2096_Spy0211 NC_008023.1 212993 213283 D deoxyuridine 5'-triphosphate nucleotidohydrolase 212993..213283 Streptococcus pyogenes MGAS2096 4064954 YP_599808.1 CDS MGAS2096_Spy0212 NC_008023.1 213299 213439 D deoxyuridine 5'-triphosphate nucleotidohydrolase 213299..213439 Streptococcus pyogenes MGAS2096 4064955 YP_599809.1 CDS radA NC_008023.1 213520 214881 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 213520..214881 Streptococcus pyogenes MGAS2096 4064956 YP_599810.1 CDS MGAS2096_Spy0214 NC_008023.1 215067 215474 D carbonic anhydrase 215067..215474 Streptococcus pyogenes MGAS2096 4064957 YP_599811.1 CDS MGAS2096_Spy0215 NC_008023.1 215407 215568 D carbonic anhydrase 215407..215568 Streptococcus pyogenes MGAS2096 4064958 YP_599812.1 CDS MGAS2096_Spy0216 NC_008023.1 215663 216409 D hypothetical protein 215663..216409 Streptococcus pyogenes MGAS2096 4064959 YP_599813.1 CDS MGAS2096_Spy0217 NC_008023.1 216607 217290 D glutamyl-tRNA synthetase 216607..217290 Streptococcus pyogenes MGAS2096 4064960 YP_599814.1 CDS gltX NC_008023.1 217287 218051 D glutamyl-tRNA synthetase 217287..218051 Streptococcus pyogenes MGAS2096 4064961 YP_599815.1 CDS fasB NC_008023.1 218447 219793 D sensory transduction protein kinase FasB 218447..219793 Streptococcus pyogenes MGAS2096 4066402 YP_599816.1 CDS fasC NC_008023.1 219790 221073 D sensory transduction protein kinase FasC 219790..221073 Streptococcus pyogenes MGAS2096 4066403 YP_599817.1 CDS fasA NC_008023.1 221077 221817 D response regulator FasA 221077..221817 Streptococcus pyogenes MGAS2096 4066404 YP_599818.1 CDS rnpA NC_008023.1 222357 222716 D protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 222357..222716 Streptococcus pyogenes MGAS2096 4066405 YP_599819.1 CDS MGAS2096_Spy0223 NC_008023.1 222682 223509 D 60 kDa inner membrane protein YIDC 222682..223509 Streptococcus pyogenes MGAS2096 4066406 YP_599820.1 CDS MGAS2096_Spy0224 NC_008023.1 223521 223790 D Jag protein 223521..223790 Streptococcus pyogenes MGAS2096 4066407 YP_599821.1 CDS MGAS2096_Spy0225 NC_008023.1 223834 224259 D Jag protein 223834..224259 Streptococcus pyogenes MGAS2096 4066408 YP_599822.1 CDS MGAS2096_Spy0226 NC_008023.1 224228 224437 D Jag protein 224228..224437 Streptococcus pyogenes MGAS2096 4066409 YP_599823.1 CDS MGAS2096_Spy0227 NC_008023.1 224520 224642 D hypothetical protein 224520..224642 Streptococcus pyogenes MGAS2096 4066410 YP_599824.1 CDS rpmH NC_008023.1 224750 224884 D in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 224750..224884 Streptococcus pyogenes MGAS2096 4066411 YP_599825.1 CDS MGAS2096_Spy0229 NC_008023.1 225158 225862 D Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 225158..225862 Streptococcus pyogenes MGAS2096 4066412 YP_599826.1 CDS MGAS2096_Spy0230 NC_008023.1 225911 226147 D N-acetylneuraminate-binding protein 225911..226147 Streptococcus pyogenes MGAS2096 4066413 YP_599827.1 CDS MGAS2096_Spy0231 NC_008023.1 226150 227229 D N-acetylneuraminate-binding protein 226150..227229 Streptococcus pyogenes MGAS2096 4066414 YP_599828.1 CDS MGAS2096_Spy0232 NC_008023.1 227333 228220 D N-acetylneuraminate transport system permease 227333..228220 Streptococcus pyogenes MGAS2096 4066415 YP_599829.1 CDS MGAS2096_Spy0233 NC_008023.1 228233 229063 D N-acetylneuraminate transport system permease 228233..229063 Streptococcus pyogenes MGAS2096 4066416 YP_599830.1 CDS MGAS2096_Spy0234 NC_008023.1 229220 229882 D hypothetical protein 229220..229882 Streptococcus pyogenes MGAS2096 4066417 YP_599831.1 CDS nanH NC_008023.1 229894 230808 D N-acetylneuraminate lyase 229894..230808 Streptococcus pyogenes MGAS2096 4066418 YP_599832.1 CDS MGAS2096_Spy0236 NC_008023.1 230830 231768 D N-acetylmannosamine kinase / transcriptional regulator 230830..231768 Streptococcus pyogenes MGAS2096 4066419 YP_599833.1 CDS MGAS2096_Spy0237 NC_008023.1 231879 232721 R RpiR family transcriptional regulator complement(231879..232721) Streptococcus pyogenes MGAS2096 4066420 YP_599834.1 CDS tatD NC_008023.1 232898 233785 D TatD family deoxyribonuclease 232898..233785 Streptococcus pyogenes MGAS2096 4066421 YP_599835.1 CDS MGAS2096_Spy0239 NC_008023.1 233736 234347 D ribonuclease M5 233736..234347 Streptococcus pyogenes MGAS2096 4064864 YP_599836.1 CDS ksgA NC_008023.1 234437 235333 D catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 234437..235333 Streptococcus pyogenes MGAS2096 4064865 YP_599837.1 CDS MGAS2096_Spy0241 NC_008023.1 235757 236629 D EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 235757..236629 Streptococcus pyogenes MGAS2096 4064866 YP_599838.1 CDS rpe NC_008023.1 236639 237301 D catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 236639..237301 Streptococcus pyogenes MGAS2096 4064867 YP_599839.1 CDS MGAS2096_Spy0243 NC_008023.1 237294 237926 D thiamin pyrophosphokinase 237294..237926 Streptococcus pyogenes MGAS2096 4064868 YP_599840.1 CDS MGAS2096_Spy0244 NC_008023.1 237928 239199 D RmuC family protein 237928..239199 Streptococcus pyogenes MGAS2096 4064869 YP_599841.1 CDS cbf NC_008023.1 239189 240127 D CMP-binding factor 239189..240127 Streptococcus pyogenes MGAS2096 4064870 YP_599842.1 CDS purR NC_008023.1 240394 241233 D pur operon repressor 240394..241233 Streptococcus pyogenes MGAS2096 4064871 YP_599843.1 CDS prgA NC_008023.1 241206 243845 D surface exclusion protein 241206..243845 Streptococcus pyogenes MGAS2096 4064872 YP_599844.1 CDS rpsL NC_008023.1 244053 244496 D interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 244053..244496 Streptococcus pyogenes MGAS2096 4064873 YP_599845.1 CDS rpsG NC_008023.1 244486 244956 D binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 244486..244956 Streptococcus pyogenes MGAS2096 4064874 YP_599846.1 CDS MGAS2096_Spy0250 NC_008023.1 245323 245631 D protein translation elongation factor G (EF-G) 245323..245631 Streptococcus pyogenes MGAS2096 4064875 YP_599847.1 CDS fus NC_008023.1 245577 247400 D protein translation elongation factor G (EF-G) 245577..247400 Streptococcus pyogenes MGAS2096 4064876 YP_599848.1 CDS plr NC_008023.1 247721 248758 D glyceraldehyde-3-phosphate dehydrogenase 247721..248758 Streptococcus pyogenes MGAS2096 4064877 YP_599849.1 CDS MGAS2096_Spy0253 NC_008023.1 249244 250053 R amino acid ABC transporter ATP-binding protein complement(249244..250053) Streptococcus pyogenes MGAS2096 4064878 YP_599850.1 CDS MGAS2096_Spy0254 NC_008023.1 249977 251140 R amino acid ABC transporter permease complement(249977..251140) Streptococcus pyogenes MGAS2096 4064879 YP_599851.1 CDS MGAS2096_Spy0255 NC_008023.1 251100 251564 R amino acid ABC transporter permease complement(251100..251564) Streptococcus pyogenes MGAS2096 4064880 YP_599852.1 CDS MGAS2096_Spy0256 NC_008023.1 251744 253669 D hypothetical protein 251744..253669 Streptococcus pyogenes MGAS2096 4064881 YP_599853.1 CDS bacA NC_008023.1 253735 254574 D BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 253735..254574 Streptococcus pyogenes MGAS2096 4064882 YP_599854.1 CDS mecA NC_008023.1 254714 255481 D enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence; adaptor protein 254714..255481 Streptococcus pyogenes MGAS2096 4064634 YP_599855.1 CDS MGAS2096_Spy0259 NC_008023.1 255488 256657 D undecaprenyl-phosphate alpha-N-acetylglucosaminephosphotransferase 255488..256657 Streptococcus pyogenes MGAS2096 4064635 YP_599856.1 CDS rgpG NC_008023.1 256627 256752 D putative cytoplasmic protein 256627..256752 Streptococcus pyogenes MGAS2096 4064636 YP_599857.1 CDS MGAS2096_Spy0261 NC_008023.1 256779 257549 D ATP-dependent transporter sufC 256779..257549 Streptococcus pyogenes MGAS2096 4064637 YP_599858.1 CDS MGAS2096_Spy0262 NC_008023.1 257644 258906 D SufD protein 257644..258906 Streptococcus pyogenes MGAS2096 4064638 YP_599859.1 CDS nifS3 NC_008023.1 258937 260163 D bifunctional; cysteine desulfurase / selenocysteine lyase 258937..260163 Streptococcus pyogenes MGAS2096 4064639 YP_599860.1 CDS nifU NC_008023.1 260150 260629 D IscU protein 260150..260629 Streptococcus pyogenes MGAS2096 4064640 YP_599861.1 CDS MGAS2096_Spy0265 NC_008023.1 260622 262040 D ABC transporter-associated protein sufB 260622..262040 Streptococcus pyogenes MGAS2096 4064641 YP_599862.1 CDS MGAS2096_Spy0266 NC_008023.1 262192 262692 R D-alanyl-D-alanine carboxypeptidase complement(262192..262692) Streptococcus pyogenes MGAS2096 4064642 YP_599863.1 CDS MGAS2096_Spy0267 NC_008023.1 262677 263372 R D-alanyl-D-alanine carboxypeptidase complement(262677..263372) Streptococcus pyogenes MGAS2096 4064643 YP_599864.1 CDS MGAS2096_Spy0268 NC_008023.1 263541 263921 R D-alanyl-D-alanine carboxypeptidase complement(263541..263921) Streptococcus pyogenes MGAS2096 4064644 YP_599865.1 CDS dacA2 NC_008023.1 263945 264772 R D-alanyl-D-alanine carboxypeptidase complement(263945..264772) Streptococcus pyogenes MGAS2096 4064645 YP_599866.1 CDS oppA NC_008023.1 265094 267073 D oligopeptide-binding protein oppA 265094..267073 Streptococcus pyogenes MGAS2096 4064646 YP_599867.1 CDS oppB NC_008023.1 267126 268640 D oligopeptide transport system permease oppB 267126..268640 Streptococcus pyogenes MGAS2096 4064647 YP_599868.1 CDS oppC NC_008023.1 268640 269566 D oligopeptide transport system permease oppC 268640..269566 Streptococcus pyogenes MGAS2096 4064648 YP_599869.1 CDS oppD NC_008023.1 269575 270645 D oligopeptide transport ATP-binding protein oppD 269575..270645 Streptococcus pyogenes MGAS2096 4064649 YP_599870.1 CDS oppF NC_008023.1 270638 271561 D oligopeptide transport ATP-binding protein oppF 270638..271561 Streptococcus pyogenes MGAS2096 4064650 YP_599871.1 CDS MGAS2096_Spy0275 NC_008023.1 271710 271949 R transposase complement(271710..271949) Streptococcus pyogenes MGAS2096 4064651 YP_599872.1 CDS MGAS2096_Spy0276 NC_008023.1 272324 272458 R hypothetical protein complement(272324..272458) Streptococcus pyogenes MGAS2096 4064652 YP_599873.1 CDS comX2 NC_008023.1 277946 278431 D competence-specific sigma factor ComX 277946..278431 Streptococcus pyogenes MGAS2096 4066382 YP_599874.1 CDS MGAS2096_Spy0278 NC_008023.1 278933 279517 D putative lipase 278933..279517 Streptococcus pyogenes MGAS2096 4066383 YP_599875.1 CDS MGAS2096_Spy0279 NC_008023.1 279517 280635 D in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis; GTP-binding protein YqeH 279517..280635 Streptococcus pyogenes MGAS2096 4066384 YP_599876.1 CDS MGAS2096_Spy0280 NC_008023.1 280660 280968 D RNA-binding protein 280660..280968 Streptococcus pyogenes MGAS2096 4066385 YP_599877.1 CDS nadD NC_008023.1 281037 281669 D transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 281037..281669 Streptococcus pyogenes MGAS2096 4066386 YP_599878.1 CDS MGAS2096_Spy0282 NC_008023.1 281666 282259 D HAD superfamily; hydrolase 281666..282259 Streptococcus pyogenes MGAS2096 4066387 YP_599879.1 CDS MGAS2096_Spy0283 NC_008023.1 282235 282636 D iojap superfamily protein 282235..282636 Streptococcus pyogenes MGAS2096 4066388 YP_599880.1 CDS MGAS2096_Spy0284 NC_008023.1 282636 283427 D methyltransferase 282636..283427 Streptococcus pyogenes MGAS2096 4066389 YP_599881.1 CDS MGAS2096_Spy0285 NC_008023.1 283649 284755 D hypothetical protein 283649..284755 Streptococcus pyogenes MGAS2096 4066390 YP_599882.1 CDS MGAS2096_Spy0286 NC_008023.1 285107 285247 D hypothetical protein 285107..285247 Streptococcus pyogenes MGAS2096 4066391 YP_599883.1 CDS MGAS2096_Spy0287 NC_008023.1 285237 285953 D hypothetical protein 285237..285953 Streptococcus pyogenes MGAS2096 4064732 YP_599884.1 CDS MGAS2096_Spy0288 NC_008023.1 286156 286938 D ABC transporter substrate-binding protein 286156..286938 Streptococcus pyogenes MGAS2096 4064733 YP_599885.1 CDS MGAS2096_Spy0289 NC_008023.1 287327 288172 D ABC transporter substrate-binding protein 287327..288172 Streptococcus pyogenes MGAS2096 4064734 YP_599886.1 CDS MGAS2096_Spy0290 NC_008023.1 288427 289491 D ABC transporter ATP-binding protein 288427..289491 Streptococcus pyogenes MGAS2096 4064735 YP_599887.1 CDS MGAS2096_Spy0291 NC_008023.1 289492 290184 D ABC transporter permease 289492..290184 Streptococcus pyogenes MGAS2096 4064736 YP_599888.1 CDS MGAS2096_Spy0292 NC_008023.1 291845 293059 D involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 291845..293059 Streptococcus pyogenes MGAS2096 4064737 YP_599889.1 CDS MGAS2096_Spy0293 NC_008023.1 293114 293788 R potassium uptake protein ktrA complement(293114..293788) Streptococcus pyogenes MGAS2096 4064738 YP_599890.1 CDS MGAS2096_Spy0294 NC_008023.1 293798 295189 R potassium uptake protein ktrB complement(293798..295189) Streptococcus pyogenes MGAS2096 4064739 YP_599891.1 CDS gidB NC_008023.1 295259 295972 R glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB complement(295259..295972) Streptococcus pyogenes MGAS2096 4064740 YP_599892.1 CDS lemA NC_008023.1 296122 296679 D LemA protein 296122..296679 Streptococcus pyogenes MGAS2096 4064741 YP_599893.1 CDS MGAS2096_Spy0297 NC_008023.1 296726 297157 D heat shock protein HtpX 296726..297157 Streptococcus pyogenes MGAS2096 4064742 YP_599894.1 CDS MGAS2096_Spy0298 NC_008023.1 297209 297622 D heat shock protein HtpX 297209..297622 Streptococcus pyogenes MGAS2096 4064743 YP_599895.1 CDS MGAS2096_Spy0299 NC_008023.1 297853 298389 D putative cytoplasmic protein 297853..298389 Streptococcus pyogenes MGAS2096 4064744 YP_599896.1 CDS covR NC_008023.1 298655 299341 D response regulator CsrR 298655..299341 Streptococcus pyogenes MGAS2096 4064745 YP_599897.1 CDS covS NC_008023.1 299347 300849 D transmembrane histidine kinase CsrS 299347..300849 Streptococcus pyogenes MGAS2096 4064746 YP_599898.1 CDS nrdR NC_008023.1 301064 301558 D transcriptional regulator NrdR 301064..301558 Streptococcus pyogenes MGAS2096 4064747 YP_599899.1 CDS dnaB NC_008023.1 301542 302717 D replicative DNA helicase 301542..302717 Streptococcus pyogenes MGAS2096 4064748 YP_599900.1 CDS dnaI NC_008023.1 302718 303620 D Primosomal protein that may act to load helicase DnaC during DNA replication; primosomal protein DnaI 302718..303620 Streptococcus pyogenes MGAS2096 4064749 YP_599901.1 CDS engA NC_008023.1 303683 304993 D EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 303683..304993 Streptococcus pyogenes MGAS2096 4064750 YP_599902.1 CDS snf NC_008023.1 305200 308298 D SWF/SNF family helicase 305200..308298 Streptococcus pyogenes MGAS2096 4064751 YP_599903.1 CDS MGAS2096_Spy0307 NC_008023.1 308541 309143 D putative cytoplasmic protein 308541..309143 Streptococcus pyogenes MGAS2096 4066288 YP_599904.1 CDS murC NC_008023.1 309183 310511 D Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 309183..310511 Streptococcus pyogenes MGAS2096 4066289 YP_599905.1 CDS MGAS2096_Spy0309 NC_008023.1 310557 311039 D acetyltransferase 310557..311039 Streptococcus pyogenes MGAS2096 4066290 YP_599906.1 CDS MGAS2096_Spy0310 NC_008023.1 311151 312725 D hypothetical protein 311151..312725 Streptococcus pyogenes MGAS2096 4066291 YP_599907.1 CDS greA NC_008023.1 312750 313280 D necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 312750..313280 Streptococcus pyogenes MGAS2096 4066292 YP_599908.1 CDS MGAS2096_Spy0312 NC_008023.1 313495 313638 R transposase complement(313495..313638) Streptococcus pyogenes MGAS2096 4066293 YP_599909.1 CDS MGAS2096_Spy0313 NC_008023.1 313904 314827 R involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site; OxaA-like protein precursor complement(313904..314827) Streptococcus pyogenes MGAS2096 4066294 YP_599910.1 CDS MGAS2096_Spy0314 NC_008023.1 314909 315220 R catalyzes the hydrolysis of acylphosphate; acylphosphatase complement(314909..315220) Streptococcus pyogenes MGAS2096 4066295 YP_599911.1 CDS MGAS2096_Spy0315 NC_008023.1 315448 316185 D 23S rRNA methyltransferase 315448..316185 Streptococcus pyogenes MGAS2096 4066296 YP_599912.1 CDS MGAS2096_Spy0316 NC_008023.1 316224 316724 D HAD superfamily; hydrolase 316224..316724 Streptococcus pyogenes MGAS2096 4066297 YP_599913.1 CDS MGAS2096_Spy0317 NC_008023.1 316739 317428 D integral membrane protein 316739..317428 Streptococcus pyogenes MGAS2096 4066298 YP_599914.1 CDS MGAS2096_Spy0318 NC_008023.1 317606 317848 D hypothetical protein 317606..317848 Streptococcus pyogenes MGAS2096 4066299 YP_599915.1 CDS MGAS2096_Spy0319 NC_008023.1 317906 318001 R putative cytoplasmic protein complement(317906..318001) Streptococcus pyogenes MGAS2096 4066300 YP_599916.1 CDS glr NC_008023.1 318026 318820 D converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 318026..318820 Streptococcus pyogenes MGAS2096 4066301 YP_599917.1 CDS MGAS2096_Spy0321 NC_008023.1 318778 319803 D HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein 318778..319803 Streptococcus pyogenes MGAS2096 4066302 YP_599918.1 CDS MGAS2096_Spy0322 NC_008023.1 319782 320303 D putative phosphoesterase 319782..320303 Streptococcus pyogenes MGAS2096 4066303 YP_599919.1 CDS MGAS2096_Spy0323 NC_008023.1 320300 320761 D hypothetical protein 320300..320761 Streptococcus pyogenes MGAS2096 4066304 YP_599920.1 CDS xerD NC_008023.1 320758 321504 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 320758..321504 Streptococcus pyogenes MGAS2096 4066305 YP_599921.1 CDS scpA NC_008023.1 321504 322208 D functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB; segregation and condensation protein A 321504..322208 Streptococcus pyogenes MGAS2096 4066306 YP_599922.1 CDS scpB NC_008023.1 322205 322756 D functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer; segregation and condensation protein B 322205..322756 Streptococcus pyogenes MGAS2096 4065156 YP_599923.1 CDS MGAS2096_Spy0327 NC_008023.1 322937 323599 D ribosomal large subunit pseudouridine synthase B 322937..323599 Streptococcus pyogenes MGAS2096 4065157 YP_599924.1 CDS MGAS2096_Spy0328 NC_008023.1 323596 323859 D hypothetical protein 323596..323859 Streptococcus pyogenes MGAS2096 4065158 YP_599925.1 CDS MGAS2096_Spy0329 NC_008023.1 324001 324585 D 23S rRNA methyltransferase 324001..324585 Streptococcus pyogenes MGAS2096 4065159 YP_599926.1 CDS MGAS2096_Spy0330 NC_008023.1 324897 325460 D riboflavin transporter 324897..325460 Streptococcus pyogenes MGAS2096 4065160 YP_599927.1 CDS MGAS2096_Spy0331 NC_008023.1 325462 326115 D membrane-associated phospholipid phosphatase 325462..326115 Streptococcus pyogenes MGAS2096 4065161 YP_599928.1 CDS MGAS2096_Spy0332 NC_008023.1 326390 327328 D radical SAM superfamily protein 326390..327328 Streptococcus pyogenes MGAS2096 4065162 YP_599929.1 CDS MGAS2096_Spy0333 NC_008023.1 327340 327921 D SAM-dependent methyltransferase 327340..327921 Streptococcus pyogenes MGAS2096 4065163 YP_599930.1 CDS hlyX NC_008023.1 328015 329388 D magnesium and cobalt efflux protein corC 328015..329388 Streptococcus pyogenes MGAS2096 4065164 YP_599931.1 CDS pflC NC_008023.1 329394 330257 D pyruvate formate-lyase activating enzyme 329394..330257 Streptococcus pyogenes MGAS2096 4065165 YP_599932.1 CDS ppaC NC_008023.1 330382 331323 D catalyzes the hydrolysis of pyrophosphate to phosphate; putative manganese-dependent inorganic pyrophosphatase 330382..331323 Streptococcus pyogenes MGAS2096 4065166 YP_599933.1 CDS MGAS2096_Spy0337 NC_008023.1 331399 332052 D putative cytoplasmic protein 331399..332052 Streptococcus pyogenes MGAS2096 4065167 YP_599934.1 CDS fhuG NC_008023.1 332097 333134 R ferrichrome transport system permease fhuG complement(332097..333134) Streptococcus pyogenes MGAS2096 4065168 YP_599935.1 CDS fhuB NC_008023.1 333095 334147 R ferrichrome transport system permease fhuB complement(333095..334147) Streptococcus pyogenes MGAS2096 4065169 YP_599936.1 CDS fhuD NC_008023.1 334137 335069 R ferrichrome-binding protein complement(334137..335069) Streptococcus pyogenes MGAS2096 4065170 YP_599937.1 CDS fhuA NC_008023.1 335095 335877 R ferrichrome ABC transporter ATP-binding protein complement(335095..335877) Streptococcus pyogenes MGAS2096 4065171 YP_599938.1 CDS MGAS2096_Spy0342 NC_008023.1 336123 336488 R UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-- lysine ligase complement(336123..336488) Streptococcus pyogenes MGAS2096 4065172 YP_599939.1 CDS murE NC_008023.1 336506 337567 R UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-- lysine ligase complement(336506..337567) Streptococcus pyogenes MGAS2096 4065173 YP_599940.1 CDS MGAS2096_Spy0344 NC_008023.1 337655 339289 D export protein for polysaccharides and teichoic acids 337655..339289 Streptococcus pyogenes MGAS2096 4065174 YP_599941.1 CDS MGAS2096_Spy0345 NC_008023.1 339457 339606 D uracil phosphoribosyltransferase 339457..339606 Streptococcus pyogenes MGAS2096 4065175 YP_599942.1 CDS upp NC_008023.1 339706 340086 D uracil phosphoribosyltransferase 339706..340086 Streptococcus pyogenes MGAS2096 4065058 YP_599943.1 CDS clpP NC_008023.1 340310 340900 D hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 340310..340900 Streptococcus pyogenes MGAS2096 4065059 YP_599944.1 CDS MGAS2096_Spy0348 NC_008023.1 341941 343083 D transposase 341941..343083 Streptococcus pyogenes MGAS2096 4065060 YP_599945.1 CDS MGAS2096_Spy0349 NC_008023.1 343088 343219 D hypothetical protein 343088..343219 Streptococcus pyogenes MGAS2096 4065061 YP_599946.1 CDS tmk NC_008023.1 343168 343881 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 343168..343881 Streptococcus pyogenes MGAS2096 4065062 YP_599947.1 CDS dnaX NC_008023.1 343899 344774 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA.; DNA polymerase III subunit delta' 343899..344774 Streptococcus pyogenes MGAS2096 4065063 YP_599948.1 CDS MGAS2096_Spy0352 NC_008023.1 344896 345033 D tpl protein 344896..345033 Streptococcus pyogenes MGAS2096 4065064 YP_599949.1 CDS MGAS2096_Spy0353 NC_008023.1 345177 345341 R putative cytoplasmic protein complement(345177..345341) Streptococcus pyogenes MGAS2096 4065065 YP_599950.1 CDS MGAS2096_Spy0354 NC_008023.1 345438 345761 D in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA; DNA replication intiation control protein YabA 345438..345761 Streptococcus pyogenes MGAS2096 4065066 YP_599951.1 CDS MGAS2096_Spy0355 NC_008023.1 345766 346629 D tetrapyrrole (Corrin/Porphyrin) methylase family protein 345766..346629 Streptococcus pyogenes MGAS2096 4065067 YP_599952.1 CDS MGAS2096_Spy0356 NC_008023.1 346710 347051 D hypothetical protein 346710..347051 Streptococcus pyogenes MGAS2096 4065068 YP_599953.1 CDS cutC NC_008023.1 347098 347727 R copper homeostasis protein cutC complement(347098..347727) Streptococcus pyogenes MGAS2096 4065069 YP_599954.1 CDS MGAS2096_Spy0358 NC_008023.1 348026 348382 D arsenate reductase family protein 348026..348382 Streptococcus pyogenes MGAS2096 4065070 YP_599955.1 CDS exoA NC_008023.1 348456 349367 R exodeoxyribonuclease III complement(348456..349367) Streptococcus pyogenes MGAS2096 4065071 YP_599956.1 CDS lctO NC_008023.1 349511 350698 D L-lactate oxidase 349511..350698 Streptococcus pyogenes MGAS2096 4065072 YP_599957.1 CDS spyCEP NC_008023.1 350963 355906 D interleukin-8 protease 350963..355906 Streptococcus pyogenes MGAS2096 4065073 YP_599958.1 CDS MGAS2096_Spy0362 NC_008023.1 356397 356576 D hypothetical protein 356397..356576 Streptococcus pyogenes MGAS2096 4065074 YP_599959.1 CDS MGAS2096_Spy0363 NC_008023.1 356654 357385 D hypothetical protein 356654..357385 Streptococcus pyogenes MGAS2096 4065075 YP_599960.1 CDS metS NC_008023.1 357626 359626 D methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 357626..359626 Streptococcus pyogenes MGAS2096 4065076 YP_599961.1 CDS MGAS2096_Spy0365 NC_008023.1 359954 360124 D hypothetical protein 359954..360124 Streptococcus pyogenes MGAS2096 4064923 YP_599962.1 CDS nrdF NC_008023.1 360121 361134 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 360121..361134 Streptococcus pyogenes MGAS2096 4064924 YP_599963.1 CDS nrdI NC_008023.1 361138 361626 D in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 361138..361626 Streptococcus pyogenes MGAS2096 4064925 YP_599964.1 CDS nrdE1 NC_008023.1 361593 363773 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 361593..363773 Streptococcus pyogenes MGAS2096 4064926 YP_599965.1 CDS MGAS2096_Spy0369 NC_008023.1 363793 363972 D hypothetical protein 363793..363972 Streptococcus pyogenes MGAS2096 4064927 YP_599966.1 CDS spyA NC_008023.1 363978 364730 R C3 family ADP-ribosyltransferase complement(363978..364730) Streptococcus pyogenes MGAS2096 4064928 YP_599967.1 CDS MGAS2096_Spy0371 NC_008023.1 365164 365676 D hypothetical protein 365164..365676 Streptococcus pyogenes MGAS2096 4064929 YP_599968.1 CDS MGAS2096_Spy0372 NC_008023.1 366154 366606 D hypothetical protein 366154..366606 Streptococcus pyogenes MGAS2096 4064930 YP_599969.1 CDS MGAS2096_Spy0373 NC_008023.1 367050 367463 D hypothetical protein 367050..367463 Streptococcus pyogenes MGAS2096 4064931 YP_599970.1 CDS MGAS2096_Spy0374 NC_008023.1 367656 367955 D hypothetical protein 367656..367955 Streptococcus pyogenes MGAS2096 4064932 YP_599971.1 CDS MGAS2096_Spy0375 NC_008023.1 368048 368680 R hypothetical protein complement(368048..368680) Streptococcus pyogenes MGAS2096 4064933 YP_599972.1 CDS MGAS2096_Spy0376 NC_008023.1 369192 370160 R hypothetical protein complement(369192..370160) Streptococcus pyogenes MGAS2096 4064934 YP_599973.1 CDS MGAS2096_Spy0377 NC_008023.1 370613 371008 D hypothetical protein 370613..371008 Streptococcus pyogenes MGAS2096 4064935 YP_599974.1 CDS fabG NC_008023.1 371001 371699 D Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 371001..371699 Streptococcus pyogenes MGAS2096 4064936 YP_599975.1 CDS MGAS2096_Spy0379 NC_008023.1 371742 372734 D NAD-dependent oxidoreductase 371742..372734 Streptococcus pyogenes MGAS2096 4064937 YP_599976.1 CDS MGAS2096_Spy0380 NC_008023.1 373061 374404 D phosphoglycerate transporter 373061..374404 Streptococcus pyogenes MGAS2096 4064938 YP_599977.1 CDS gcaD NC_008023.1 374577 375827 D bifunctional; glucosamine-1-phosphate acetyltransferase / UDP-N-acetylglucosamine pyrophosphorylase 374577..375827 Streptococcus pyogenes MGAS2096 4064939 YP_599978.1 CDS MGAS2096_Spy0382 NC_008023.1 375994 376548 D ADP-ribose pyrophosphatase 375994..376548 Streptococcus pyogenes MGAS2096 4064940 YP_599979.1 CDS MGAS2096_Spy0383 NC_008023.1 376545 376799 D hypothetical protein 376545..376799 Streptococcus pyogenes MGAS2096 4064941 YP_599980.1 CDS pfs NC_008023.1 376819 377514 D enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 376819..377514 Streptococcus pyogenes MGAS2096 4064942 YP_599981.1 CDS MGAS2096_Spy0385 NC_008023.1 377627 377845 D hypothetical protein 377627..377845 Streptococcus pyogenes MGAS2096 4065342 YP_599982.1 CDS scaR NC_008023.1 377942 378343 R Iron-dependent repressor complement(377942..378343) Streptococcus pyogenes MGAS2096 4065343 YP_599983.1 CDS MGAS2096_Spy0387 NC_008023.1 378340 378588 R Iron-dependent repressor complement(378340..378588) Streptococcus pyogenes MGAS2096 4065344 YP_599984.1 CDS mtsA NC_008023.1 378731 379666 D manganese-binding protein 378731..379666 Streptococcus pyogenes MGAS2096 4065345 YP_599985.1 CDS mtsB NC_008023.1 379703 380455 D manganese transport system ATP-binding protein 379703..380455 Streptococcus pyogenes MGAS2096 4065346 YP_599986.1 CDS mtsC NC_008023.1 380456 381310 D manganese transport system membrane protein 380456..381310 Streptococcus pyogenes MGAS2096 4065347 YP_599987.1 CDS MGAS2096_Spy0391 NC_008023.1 381458 382264 R peptidyl-prolyl cis-trans isomerase complement(381458..382264) Streptococcus pyogenes MGAS2096 4065348 YP_599988.1 CDS ftsK NC_008023.1 382481 384736 D cell division protein ftsK 382481..384736 Streptococcus pyogenes MGAS2096 4065349 YP_599989.1 CDS MGAS2096_Spy0393 NC_008023.1 384727 384885 D cell division protein ftsK 384727..384885 Streptococcus pyogenes MGAS2096 4065350 YP_599990.1 CDS MGAS2096_Spy0394 NC_008023.1 384955 385308 R integral membrane protein complement(384955..385308) Streptococcus pyogenes MGAS2096 4065351 YP_599991.2 CDS rplK NC_008023.1 385552 385977 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 385552..385977 Streptococcus pyogenes MGAS2096 4065352 YP_599992.1 CDS rplA NC_008023.1 386083 386772 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 386083..386772 Streptococcus pyogenes MGAS2096 4065353 YP_599993.1 CDS pyrH NC_008023.1 387094 387822 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 387094..387822 Streptococcus pyogenes MGAS2096 4065354 YP_599994.1 CDS frr NC_008023.1 387851 388408 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 387851..388408 Streptococcus pyogenes MGAS2096 4065355 YP_599995.1 CDS MGAS2096_Spy0399 NC_008023.1 388517 389374 D S1 RNA-binding domain-containing protein 388517..389374 Streptococcus pyogenes MGAS2096 4065356 YP_599996.1 CDS msrA2 NC_008023.1 389447 389956 D this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 389447..389956 Streptococcus pyogenes MGAS2096 4065357 YP_599997.1 CDS MGAS2096_Spy0401 NC_008023.1 389953 390168 D hypothetical protein 389953..390168 Streptococcus pyogenes MGAS2096 4065358 YP_599998.1 CDS MGAS2096_Spy0402 NC_008023.1 390349 391491 D surface antigen 390349..391491 Streptococcus pyogenes MGAS2096 4065359 YP_599999.1 CDS MGAS2096_Spy0403 NC_008023.1 391764 392183 D myosin-crossreactive antigen 391764..392183 Streptococcus pyogenes MGAS2096 4065360 YP_600000.1 CDS MGAS2096_Spy0404 NC_008023.1 392144 393577 D myosin-crossreactive antigen 392144..393577 Streptococcus pyogenes MGAS2096 4065673 YP_600001.1 CDS MGAS2096_Spy0405 NC_008023.1 393736 394254 D PhoH protein 393736..394254 Streptococcus pyogenes MGAS2096 4065674 YP_600002.1 CDS phoH NC_008023.1 394226 394789 D PhoH protein 394226..394789 Streptococcus pyogenes MGAS2096 4065675 YP_600003.1 CDS MGAS2096_Spy0407 NC_008023.1 394835 395410 D Uracil DNA glycosylase superfamily protein 394835..395410 Streptococcus pyogenes MGAS2096 4065676 YP_600004.1 CDS MGAS2096_Spy0408 NC_008023.1 395518 396066 D putative metalloprotease 395518..396066 Streptococcus pyogenes MGAS2096 4065677 YP_600005.1 CDS dgk NC_008023.1 396047 396454 D diacylglycerol kinase 396047..396454 Streptococcus pyogenes MGAS2096 4065678 YP_600006.1 CDS era NC_008023.1 396574 397470 D Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 396574..397470 Streptococcus pyogenes MGAS2096 4065679 YP_600007.1 CDS MGAS2096_Spy0411 NC_008023.1 397445 397966 D MutT/nudix family protein; phosphohydrolase 397445..397966 Streptococcus pyogenes MGAS2096 4065680 YP_600008.1 CDS MGAS2096_Spy0412 NC_008023.1 398272 398526 R hypothetical protein complement(398272..398526) Streptococcus pyogenes MGAS2096 4065681 YP_600009.1 CDS MGAS2096_Spy0413 NC_008023.1 398754 399335 R transposase complement(398754..399335) Streptococcus pyogenes MGAS2096 4065682 YP_600010.1 CDS MGAS2096_Spy0414 NC_008023.1 399495 399806 D bacteriocin 399495..399806 Streptococcus pyogenes MGAS2096 4065683 YP_600011.1 CDS MGAS2096_Spy0415 NC_008023.1 399819 400019 D hypothetical protein 399819..400019 Streptococcus pyogenes MGAS2096 4065684 YP_600012.1 CDS silD NC_008023.1 400313 400507 D hypothetical protein 400313..400507 Streptococcus pyogenes MGAS2096 4065685 YP_600013.1 CDS MGAS2096_Spy0417 NC_008023.1 400557 400853 D hypothetical protein 400557..400853 Streptococcus pyogenes MGAS2096 4065686 YP_600014.1 CDS MGAS2096_Spy0418 NC_008023.1 401032 401433 D hypothetical protein 401032..401433 Streptococcus pyogenes MGAS2096 4065687 YP_600015.1 CDS MGAS2096_Spy0419 NC_008023.1 401472 401588 R hypothetical protein complement(401472..401588) Streptococcus pyogenes MGAS2096 4065688 YP_600016.1 CDS MGAS2096_Spy0420 NC_008023.1 401684 402754 D hypothetical protein 401684..402754 Streptococcus pyogenes MGAS2096 4065689 YP_600017.1 CDS MGAS2096_Spy0421 NC_008023.1 402847 403245 D hypothetical protein 402847..403245 Streptococcus pyogenes MGAS2096 4065690 YP_600018.1 CDS MGAS2096_Spy0422 NC_008023.1 403593 403862 R hypothetical protein complement(403593..403862) Streptococcus pyogenes MGAS2096 4065691 YP_600019.1 CDS MGAS2096_Spy0423 NC_008023.1 404063 404170 D hypothetical protein 404063..404170 Streptococcus pyogenes MGAS2096 4065692 YP_600020.1 CDS MGAS2096_Spy0424 NC_008023.1 404257 404436 R hypothetical protein complement(404257..404436) Streptococcus pyogenes MGAS2096 4064962 YP_600021.1 CDS MGAS2096_Spy0425 NC_008023.1 404385 404627 R hypothetical protein complement(404385..404627) Streptococcus pyogenes MGAS2096 4064963 YP_600022.1 CDS mutR NC_008023.1 404919 405800 D transcriptional regulator 404919..405800 Streptococcus pyogenes MGAS2096 4064964 YP_600023.1 CDS fpg NC_008023.1 405972 406799 D Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 405972..406799 Streptococcus pyogenes MGAS2096 4064965 YP_600024.1 CDS coaE NC_008023.1 406769 407389 D catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 406769..407389 Streptococcus pyogenes MGAS2096 4064966 YP_600025.1 CDS MGAS2096_Spy0429 NC_008023.1 407579 409081 D ATPase 407579..409081 Streptococcus pyogenes MGAS2096 4064967 YP_600026.1 CDS MGAS2096_Spy0430 NC_008023.1 409203 410396 D multidrug resistance efflux pump 409203..410396 Streptococcus pyogenes MGAS2096 4064968 YP_600027.1 CDS rpmG NC_008023.1 410393 410539 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 410393..410539 Streptococcus pyogenes MGAS2096 4064969 YP_600028.1 CDS secG NC_008023.1 410585 410821 D preprotein translocase subunit SecG 410585..410821 Streptococcus pyogenes MGAS2096 4064970 YP_600029.1 CDS MGAS2096_Spy0433 NC_008023.1 410915 413248 D exoribonuclease II 410915..413248 Streptococcus pyogenes MGAS2096 4064971 YP_600030.1 CDS smpB NC_008023.1 413251 413718 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 413251..413718 Streptococcus pyogenes MGAS2096 4064972 YP_600031.1 CDS MGAS2096_Spy0435 NC_008023.1 413724 414443 D glutaminyl-peptide cyclotransferase 413724..414443 Streptococcus pyogenes MGAS2096 4064973 YP_600032.1 CDS pcp NC_008023.1 414558 415205 R catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase complement(414558..415205) Streptococcus pyogenes MGAS2096 4064974 YP_600033.1 CDS MGAS2096_Spy0437 NC_008023.1 415255 416181 R permease complement(415255..416181) Streptococcus pyogenes MGAS2096 4064975 YP_600034.1 CDS MGAS2096_Spy0438 NC_008023.1 416181 416921 R permease complement(416181..416921) Streptococcus pyogenes MGAS2096 4064976 YP_600035.1 CDS MGAS2096_Spy0439 NC_008023.1 417075 418061 R bactoprenol glucosyl transferase complement(417075..418061) Streptococcus pyogenes MGAS2096 4064977 YP_600036.1 CDS gloA NC_008023.1 418146 418523 R lactoylglutathione lyase complement(418146..418523) Streptococcus pyogenes MGAS2096 4064978 YP_600037.1 CDS MGAS2096_Spy0441 NC_008023.1 418534 419199 R NAD(P)H-dependent quinone reductase complement(418534..419199) Streptococcus pyogenes MGAS2096 4064979 YP_600038.1 CDS pepQ NC_008023.1 419248 420333 R Xaa-Pro aminopeptidase complement(419248..420333) Streptococcus pyogenes MGAS2096 4064980 YP_600039.1 CDS ccpA NC_008023.1 420517 421509 D catabolite control protein A 420517..421509 Streptococcus pyogenes MGAS2096 4065459 YP_600040.1 CDS MGAS2096_Spy0444 NC_008023.1 421640 422638 D glycosyltransferase 421640..422638 Streptococcus pyogenes MGAS2096 4065460 YP_600041.1 CDS MGAS2096_Spy0445 NC_008023.1 422640 423974 D 1,2-diacylglycerol 3-glucosyltransferase 422640..423974 Streptococcus pyogenes MGAS2096 4065461 YP_600042.1 CDS thrS NC_008023.1 424396 426339 D catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 424396..426339 Streptococcus pyogenes MGAS2096 4065462 YP_600043.1 CDS drrA NC_008023.1 426480 427472 D daunorubicin resistance ATP-binding protein drrA 426480..427472 Streptococcus pyogenes MGAS2096 4065463 YP_600044.1 CDS MGAS2096_Spy0448 NC_008023.1 427423 428292 D daunorubicin resistance transmembrane protein 427423..428292 Streptococcus pyogenes MGAS2096 4065464 YP_600045.1 CDS MGAS2096_Spy0449 NC_008023.1 428294 429079 D ABC transporter permease 428294..429079 Streptococcus pyogenes MGAS2096 4065465 YP_600046.1 CDS MGAS2096_Spy0450 NC_008023.1 429165 429314 D dihydroxyacetone kinase 429165..429314 Streptococcus pyogenes MGAS2096 4065466 YP_600047.1 CDS MGAS2096_Spy0451 NC_008023.1 429709 430857 D Acetyl-CoA acetyltransferase 429709..430857 Streptococcus pyogenes MGAS2096 4065467 YP_600048.1 CDS MGAS2096_Spy0452 NC_008023.1 430814 432061 D long-chain-fatty-acid--CoA ligase 430814..432061 Streptococcus pyogenes MGAS2096 4065468 YP_600049.1 CDS MGAS2096_Spy0453 NC_008023.1 432117 433151 D putative cytoplasmic protein 432117..433151 Streptococcus pyogenes MGAS2096 4065469 YP_600050.1 CDS vicR NC_008023.1 433313 434023 D two-component response regulator VicR 433313..434023 Streptococcus pyogenes MGAS2096 4065470 YP_600051.1 CDS vicK NC_008023.1 434016 435368 D two-component sensor histidine kinase VicK 434016..435368 Streptococcus pyogenes MGAS2096 4065471 YP_600052.1 CDS vicX NC_008023.1 435372 436181 D beta-lactamase superfamily; Zn-dependent hydrolase 435372..436181 Streptococcus pyogenes MGAS2096 4065472 YP_600053.1 CDS rnc NC_008023.1 436613 437305 D cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 436613..437305 Streptococcus pyogenes MGAS2096 4065473 YP_600054.1 CDS smc NC_008023.1 437306 440845 D chromosome partition protein smc 437306..440845 Streptococcus pyogenes MGAS2096 4065474 YP_600055.1 CDS MGAS2096_Spy0459 NC_008023.1 441098 441970 R transcriptional regulator complement(441098..441970) Streptococcus pyogenes MGAS2096 4065475 YP_600056.1 CDS aroE NC_008023.1 442169 443095 D AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 442169..443095 Streptococcus pyogenes MGAS2096 4065476 YP_600057.1 CDS MGAS2096_Spy0461 NC_008023.1 443092 443928 D putative cytoplasmic protein 443092..443928 Streptococcus pyogenes MGAS2096 4065477 YP_600058.1 CDS MGAS2096_Spy0462 NC_008023.1 443906 444664 D hypothetical protein 443906..444664 Streptococcus pyogenes MGAS2096 4065478 YP_600059.1 CDS MGAS2096_Spy0463 NC_008023.1 444657 445643 D hypothetical protein 444657..445643 Streptococcus pyogenes MGAS2096 4065615 YP_600060.1 CDS metK1 NC_008023.1 445653 446852 D catalyzes the formation of S-adenosylmethionine from methionine and ATP; S-adenosylmethionine synthetase 445653..446852 Streptococcus pyogenes MGAS2096 4065616 YP_600061.1 CDS MGAS2096_Spy0465 NC_008023.1 446836 447804 D hypothetical protein 446836..447804 Streptococcus pyogenes MGAS2096 4065617 YP_600062.1 CDS MGAS2096_Spy0466 NC_008023.1 447859 448848 D cell wall biosynthesis glycosyltransferase 447859..448848 Streptococcus pyogenes MGAS2096 4065618 YP_600063.1 CDS MGAS2096_Spy0467 NC_008023.1 449357 449494 D hypothetical protein 449357..449494 Streptococcus pyogenes MGAS2096 4065619 YP_600064.1 CDS MGAS2096_Spy0468 NC_008023.1 449518 450675 D UDP-glucose 6-dehydrogenase 449518..450675 Streptococcus pyogenes MGAS2096 4065620 YP_600065.1 CDS mefE NC_008023.1 450760 451968 D macrolide-efflux protein 450760..451968 Streptococcus pyogenes MGAS2096 4065621 YP_600066.1 CDS MGAS2096_Spy0470 NC_008023.1 452071 452280 R transcriptional regulator complement(452071..452280) Streptococcus pyogenes MGAS2096 4065622 YP_600067.1 CDS MGAS2096_Spy0471 NC_008023.1 452270 452743 R chromosome segregation ATPases complement(452270..452743) Streptococcus pyogenes MGAS2096 4065623 YP_600068.1 CDS MGAS2096_Spy0472 NC_008023.1 452756 453928 R chromosome segregation ATPases complement(452756..453928) Streptococcus pyogenes MGAS2096 4065624 YP_600069.1 CDS MGAS2096_Spy0473 NC_008023.1 453919 454101 R hypothetical protein complement(453919..454101) Streptococcus pyogenes MGAS2096 4065625 YP_600070.1 CDS MGAS2096_Spy0474 NC_008023.1 454144 455238 R hypothetical protein complement(454144..455238) Streptococcus pyogenes MGAS2096 4065626 YP_600071.1 CDS MGAS2096_Spy0475 NC_008023.1 455257 455586 D plasmid stabilization system antitoxin protein 455257..455586 Streptococcus pyogenes MGAS2096 4065627 YP_600072.1 CDS MGAS2096_Spy0476 NC_008023.1 455586 455891 D plasmid stabilization system toxin protein 455586..455891 Streptococcus pyogenes MGAS2096 4065628 YP_600073.1 CDS MGAS2096_Spy0477 NC_008023.1 456024 456182 D putative cytoplasmic protein 456024..456182 Streptococcus pyogenes MGAS2096 4065629 YP_600074.1 CDS MGAS2096_Spy0478 NC_008023.1 456287 457060 D hypothetical protein 456287..457060 Streptococcus pyogenes MGAS2096 4065630 YP_600075.1 CDS MGAS2096_Spy0479 NC_008023.1 457503 458234 R transposase complement(457503..458234) Streptococcus pyogenes MGAS2096 4065631 YP_600076.1 CDS MGAS2096_Spy0481 NC_008023.1 458354 458674 R transposase complement(458354..458674) Streptococcus pyogenes MGAS2096 4065632 YP_600077.1 CDS MGAS2096_Spy0480 NC_008023.1 458649 458774 D hypothetical protein 458649..458774 Streptococcus pyogenes MGAS2096 4065633 YP_600078.1 CDS MGAS2096_Spy0482 NC_008023.1 458756 458929 R hypothetical protein complement(458756..458929) Streptococcus pyogenes MGAS2096 4065518 YP_600079.1 CDS MGAS2096_Spy0483 NC_008023.1 458933 459730 D HAD superfamily; hydrolase 458933..459730 Streptococcus pyogenes MGAS2096 4065519 YP_600080.1 CDS MGAS2096_Spy0484 NC_008023.1 459734 460558 D HAD superfamily; hydrolase 459734..460558 Streptococcus pyogenes MGAS2096 4065520 YP_600081.1 CDS ftsY NC_008023.1 460558 462108 D cell division protein ftsY 460558..462108 Streptococcus pyogenes MGAS2096 4065521 YP_600082.1 CDS MGAS2096_Spy0486 NC_008023.1 462163 463530 R multidrug resistance protein B complement(462163..463530) Streptococcus pyogenes MGAS2096 4065522 YP_600083.1 CDS licT NC_008023.1 463857 464699 D BigG family transcription antiterminator 463857..464699 Streptococcus pyogenes MGAS2096 4065523 YP_600084.1 CDS MGAS2096_Spy0488 NC_008023.1 464701 466563 D PTS system beta-glucoside-specific transporter subunit IIABC 464701..466563 Streptococcus pyogenes MGAS2096 4065524 YP_600085.1 CDS bglA NC_008023.1 466582 468006 D 6-phospho-beta-glucosidase 466582..468006 Streptococcus pyogenes MGAS2096 4065525 YP_600086.1 CDS MGAS2096_Spy0490 NC_008023.1 468105 468944 R hypothetical protein complement(468105..468944) Streptococcus pyogenes MGAS2096 4065526 YP_600087.1 CDS MGAS2096_Spy0491 NC_008023.1 468920 469822 R hypothetical protein complement(468920..469822) Streptococcus pyogenes MGAS2096 4065527 YP_600088.1 CDS MGAS2096_Spy0492 NC_008023.1 469956 470153 D hypothetical protein 469956..470153 Streptococcus pyogenes MGAS2096 4065528 YP_600089.1 CDS MGAS2096_Spy0493 NC_008023.1 470338 472491 D S1 RNA binding domain; transcription accessory protein 470338..472491 Streptococcus pyogenes MGAS2096 4065529 YP_600090.1 CDS MGAS2096_Spy0494 NC_008023.1 472433 472915 D hypothetical protein 472433..472915 Streptococcus pyogenes MGAS2096 4065530 YP_600091.1 CDS MGAS2096_Spy0495 NC_008023.1 472979 473251 D stress-responsive transcriptional regulator PspC 472979..473251 Streptococcus pyogenes MGAS2096 4065531 YP_600092.2 CDS ptsK NC_008023.1 473556 474548 D catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase 473556..474548 Streptococcus pyogenes MGAS2096 4065532 YP_600093.1 CDS lgt NC_008023.1 474545 475324 D transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 474545..475324 Streptococcus pyogenes MGAS2096 4065533 YP_600094.1 CDS MGAS2096_Spy0498 NC_008023.1 475346 475753 D hypothetical protein 475346..475753 Streptococcus pyogenes MGAS2096 4065534 YP_600095.1 CDS MGAS2096_Spy0499 NC_008023.1 475725 476174 D hypothetical protein 475725..476174 Streptococcus pyogenes MGAS2096 4065535 YP_600096.1 CDS MGAS2096_Spy0500 NC_008023.1 476334 476618 R hypothetical protein complement(476334..476618) Streptococcus pyogenes MGAS2096 4065536 YP_600097.1 CDS MGAS2096_Spy0501 NC_008023.1 476817 477743 D U32 family peptidase 476817..477743 Streptococcus pyogenes MGAS2096 4065537 YP_600098.1 CDS MGAS2096_Spy0502 NC_008023.1 477845 479131 D U32 family peptidase 477845..479131 Streptococcus pyogenes MGAS2096 4065771 YP_600099.1 CDS MGAS2096_Spy0503 NC_008023.1 479144 479272 R hypothetical protein complement(479144..479272) Streptococcus pyogenes MGAS2096 4065772 YP_600100.1 CDS MGAS2096_Spy0504 NC_008023.1 479341 479553 D putative cytoplasmic protein 479341..479553 Streptococcus pyogenes MGAS2096 4065773 YP_600101.1 CDS MGAS2096_Spy0505 NC_008023.1 479650 479790 R hypothetical protein complement(479650..479790) Streptococcus pyogenes MGAS2096 4065774 YP_600102.1 CDS lysS NC_008023.1 479926 481431 R class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(479926..481431) Streptococcus pyogenes MGAS2096 4065775 YP_600103.1 CDS MGAS2096_Spy0507 NC_008023.1 481593 482495 D haloacid dehalogenase-like hydrolase 481593..482495 Streptococcus pyogenes MGAS2096 4065776 YP_600104.1 CDS MGAS2096_Spy0508 NC_008023.1 482603 483226 R phosphoglycerate mutase family protein complement(482603..483226) Streptococcus pyogenes MGAS2096 4065777 YP_600105.1 CDS MGAS2096_Spy0509 NC_008023.1 483567 484046 R transcriptional regulator complement(483567..484046) Streptococcus pyogenes MGAS2096 4065778 YP_600106.1 CDS MGAS2096_Spy0510 NC_008023.1 484137 484745 R thiamine transporter complement(484137..484745) Streptococcus pyogenes MGAS2096 4065779 YP_600107.1 CDS MGAS2096_Spy0511 NC_008023.1 484969 485817 R N-acetylmuramoyl-L-alanine amidase complement(484969..485817) Streptococcus pyogenes MGAS2096 4065780 YP_600108.1 CDS MGAS2096_Spy0512 NC_008023.1 486142 486645 D integral membrane protein 486142..486645 Streptococcus pyogenes MGAS2096 4065781 YP_600109.1 CDS MGAS2096_Spy0513 NC_008023.1 486629 487012 D hypothetical protein 486629..487012 Streptococcus pyogenes MGAS2096 4065782 YP_600110.1 CDS MGAS2096_Spy0514 NC_008023.1 487058 487582 R glutathione peroxidase complement(487058..487582) Streptococcus pyogenes MGAS2096 4065783 YP_600111.1 CDS pepF NC_008023.1 487530 489404 R oligoendopeptidase F complement(487530..489404) Streptococcus pyogenes MGAS2096 4065784 YP_600112.1 CDS ppc NC_008023.1 489473 492286 D catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 489473..492286 Streptococcus pyogenes MGAS2096 4065785 YP_600113.1 CDS ftsW NC_008023.1 492426 493730 D cell division protein ftsW 492426..493730 Streptococcus pyogenes MGAS2096 4065786 YP_600114.1 CDS MGAS2096_Spy0518 NC_008023.1 493747 493887 R putative cytoplasmic protein complement(493747..493887) Streptococcus pyogenes MGAS2096 4065787 YP_600115.1 CDS MGAS2096_Spy0519 NC_008023.1 494033 494299 D protein translation elongation factor Tu (EF-Tu) 494033..494299 Streptococcus pyogenes MGAS2096 4065788 YP_600116.1 CDS MGAS2096_Spy0520 NC_008023.1 494244 495281 D elongation factor Tu 494244..495281 Streptococcus pyogenes MGAS2096 4065789 YP_600117.1 CDS tpiA NC_008023.1 495522 496280 D Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 495522..496280 Streptococcus pyogenes MGAS2096 4065400 YP_600118.1 CDS MGAS2096_Spy0522 NC_008023.1 496379 497614 R factor essential for expression of methicillin resistance complement(496379..497614) Streptococcus pyogenes MGAS2096 4065401 YP_600119.1 CDS murM NC_008023.1 497601 498842 R bifunctional; UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase / UDP-N-acetylmuramoylpentapeptide-lysine N(6)-seryltransferase complement(497601..498842) Streptococcus pyogenes MGAS2096 4065402 YP_600120.1 CDS MGAS2096_Spy0524 NC_008023.1 498827 499636 R HAD superfamily; hydrolase complement(498827..499636) Streptococcus pyogenes MGAS2096 4065403 YP_600121.1 CDS MGAS2096_Spy0525 NC_008023.1 499787 500020 R putative cytoplasmic protein complement(499787..500020) Streptococcus pyogenes MGAS2096 4065404 YP_600122.1 CDS MGAS2096_Spy0527 NC_008023.1 500092 501495 R dGTP triphosphohydrolase complement(500092..501495) Streptococcus pyogenes MGAS2096 4065405 YP_600123.1 CDS MGAS2096_Spy0526 NC_008023.1 501476 501862 D putative cytoplasmic protein 501476..501862 Streptococcus pyogenes MGAS2096 4065406 YP_600124.1 CDS pacL NC_008023.1 502092 504773 D calcium-transporting ATPase 502092..504773 Streptococcus pyogenes MGAS2096 4065407 YP_600125.1 CDS regR NC_008023.1 504857 505861 R LacI family transcriptional regulator complement(504857..505861) Streptococcus pyogenes MGAS2096 4065408 YP_600126.1 CDS MGAS2096_Spy0530 NC_008023.1 505916 507841 R oligohyaluronate lyase complement(505916..507841) Streptococcus pyogenes MGAS2096 4065409 YP_600127.1 CDS agaD NC_008023.1 507910 508791 R PTS system N-acetylgalactosamine-specific transporter subunit IID complement(507910..508791) Streptococcus pyogenes MGAS2096 4065410 YP_600128.1 CDS MGAS2096_Spy0532 NC_008023.1 508718 509500 R PTS system N-acetylgalactosamine-specific transporter subunit IIC complement(508718..509500) Streptococcus pyogenes MGAS2096 4065411 YP_600129.1 CDS agaV NC_008023.1 509519 510007 R PTS system N-acetylgalactosamine-specific transporter subunit IIB complement(509519..510007) Streptococcus pyogenes MGAS2096 4065412 YP_600130.1 CDS MGAS2096_Spy0534 NC_008023.1 510043 511242 R unsaturated glucuronyl hydrolase complement(510043..511242) Streptococcus pyogenes MGAS2096 4065413 YP_600131.1 CDS MGAS2096_Spy0535 NC_008023.1 511242 511679 R PTS system N-acetylgalactosamine-specific transporter subunit IIA complement(511242..511679) Streptococcus pyogenes MGAS2096 4065414 YP_600132.1 CDS idnO NC_008023.1 512004 512798 D Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase 512004..512798 Streptococcus pyogenes MGAS2096 4065415 YP_600133.1 CDS MGAS2096_Spy0537 NC_008023.1 512823 513464 D hypothetical protein 512823..513464 Streptococcus pyogenes MGAS2096 4065416 YP_600134.1 CDS MGAS2096_Spy0538 NC_008023.1 513454 514494 D 2-dehydro-3-deoxygluconokinase 513454..514494 Streptococcus pyogenes MGAS2096 4065417 YP_600135.1 CDS kgdA NC_008023.1 514481 515134 D catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 514481..515134 Streptococcus pyogenes MGAS2096 4065418 YP_600136.1 CDS MGAS2096_Spy0540 NC_008023.1 515425 516081 D bifunctional; Beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase 515425..516081 Streptococcus pyogenes MGAS2096 4065419 YP_600137.1 CDS MGAS2096_Spy0541 NC_008023.1 516727 517902 D iron-sulfur cluster-binding protein 516727..517902 Streptococcus pyogenes MGAS2096 4066241 YP_600138.1 CDS prfB NC_008023.1 518054 519067 D recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 518054..519067 Streptococcus pyogenes MGAS2096 4066242 YP_600139.1 CDS ftsE NC_008023.1 519086 519778 D cell division ATP-binding protein ftsE 519086..519778 Streptococcus pyogenes MGAS2096 4066243 YP_600140.1 CDS ftsX NC_008023.1 519741 520700 D cell division protein ftsX 519741..520700 Streptococcus pyogenes MGAS2096 4066244 YP_600141.1 CDS MGAS2096_Spy0545 NC_008023.1 521009 521707 R hydroxyacylglutathione hydrolase complement(521009..521707) Streptococcus pyogenes MGAS2096 4066245 YP_600142.1 CDS MGAS2096_Spy0546 NC_008023.1 521848 522639 D bifunctional; acetoin reductase 521848..522639 Streptococcus pyogenes MGAS2096 4066246 YP_600143.1 CDS dinG NC_008023.1 522747 525248 D unwinds DNA; bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon 522747..525248 Streptococcus pyogenes MGAS2096 4066247 YP_600144.1 CDS aspC NC_008023.1 525583 526776 D catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 525583..526776 Streptococcus pyogenes MGAS2096 4066248 YP_600145.1 CDS asnC NC_008023.1 526797 528143 D catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 526797..528143 Streptococcus pyogenes MGAS2096 4066249 YP_600146.1 CDS MGAS2096_Spy0550 NC_008023.1 528558 529448 D contains P-loop; hypothetical protein 528558..529448 Streptococcus pyogenes MGAS2096 4066250 YP_600147.1 CDS MGAS2096_Spy0551 NC_008023.1 529445 530422 D hypothetical protein 529445..530422 Streptococcus pyogenes MGAS2096 4066251 YP_600148.1 CDS MGAS2096_Spy0552 NC_008023.1 530419 531330 D putative cytoplasmic protein 530419..531330 Streptococcus pyogenes MGAS2096 4066252 YP_600149.1 CDS MGAS2096_Spy0553 NC_008023.1 531507 532922 R site-specific recombinase complement(531507..532922) Streptococcus pyogenes MGAS2096 4066253 YP_600150.1 CDS MGAS2096_Spy0554 NC_008023.1 533043 533408 R phage protein complement(533043..533408) Streptococcus pyogenes MGAS2096 4066254 YP_600151.1 CDS MGAS2096_Spy0555 NC_008023.1 533435 534196 R phage transcriptional repressor complement(533435..534196) Streptococcus pyogenes MGAS2096 4066255 YP_600152.1 CDS MGAS2096_Spy0556 NC_008023.1 534380 534610 D Cro family transcriptional regulator 534380..534610 Streptococcus pyogenes MGAS2096 4066256 YP_600153.1 CDS MGAS2096_Spy0557 NC_008023.1 534679 534816 D phage protein 534679..534816 Streptococcus pyogenes MGAS2096 4066257 YP_600154.1 CDS MGAS2096_Spy0558 NC_008023.1 534818 534943 D phage protein 534818..534943 Streptococcus pyogenes MGAS2096 4066258 YP_600155.1 CDS MGAS2096_Spy0559 NC_008023.1 534940 535167 D phage protein 534940..535167 Streptococcus pyogenes MGAS2096 4066259 YP_600156.1 CDS MGAS2096_Spy0560 NC_008023.1 535146 536486 D chromosome segregation ATPases 535146..536486 Streptococcus pyogenes MGAS2096 4064654 YP_600157.1 CDS MGAS2096_Spy0561 NC_008023.1 536501 537592 D phage protein 536501..537592 Streptococcus pyogenes MGAS2096 4064655 YP_600158.1 CDS MGAS2096_Spy0562 NC_008023.1 537632 538054 D phage protein 537632..538054 Streptococcus pyogenes MGAS2096 4064656 YP_600159.1 CDS MGAS2096_Spy0563 NC_008023.1 538056 538790 D phage protein 538056..538790 Streptococcus pyogenes MGAS2096 4064657 YP_600160.1 CDS MGAS2096_Spy0564 NC_008023.1 538812 539447 D phage protein 538812..539447 Streptococcus pyogenes MGAS2096 4064658 YP_600161.1 CDS MGAS2096_Spy0565 NC_008023.1 539432 541030 D DEAD/DEAH box family; DNA/RNA helicase 539432..541030 Streptococcus pyogenes MGAS2096 4064659 YP_600162.1 CDS MGAS2096_Spy0566 NC_008023.1 541040 541669 D hypothetical protein 541040..541669 Streptococcus pyogenes MGAS2096 4064660 YP_600163.1 CDS MGAS2096_Spy0567 NC_008023.1 541659 543932 D ATPase 541659..543932 Streptococcus pyogenes MGAS2096 4064661 YP_600164.1 CDS MGAS2096_Spy0568 NC_008023.1 544210 544428 D phage protein 544210..544428 Streptococcus pyogenes MGAS2096 4064662 YP_600165.1 CDS MGAS2096_Spy0569 NC_008023.1 544403 544816 D phage protein 544403..544816 Streptococcus pyogenes MGAS2096 4064663 YP_600166.1 CDS MGAS2096_Spy0570 NC_008023.1 544813 545034 D hypothetical protein 544813..545034 Streptococcus pyogenes MGAS2096 4064664 YP_600167.1 CDS MGAS2096_Spy0571 NC_008023.1 545037 545309 D phage protein 545037..545309 Streptococcus pyogenes MGAS2096 4064665 YP_600168.1 CDS MGAS2096_Spy0572 NC_008023.1 545245 545946 D phage protein 545245..545946 Streptococcus pyogenes MGAS2096 4064666 YP_600169.1 CDS MGAS2096_Spy0573 NC_008023.1 546219 546653 D ArpU family phage encoded transcriptional regulator 546219..546653 Streptococcus pyogenes MGAS2096 4064667 YP_600170.1 CDS MGAS2096_Spy0574 NC_008023.1 546963 548129 D chromosome partitioning protein parB / adenine-specific methyltransferase 546963..548129 Streptococcus pyogenes MGAS2096 4064668 YP_600171.1 CDS MGAS2096_Spy0575 NC_008023.1 548472 548948 D phage protein 548472..548948 Streptococcus pyogenes MGAS2096 4064669 YP_600172.1 CDS MGAS2096_Spy0576 NC_008023.1 549031 550242 D terminase large subunit 549031..550242 Streptococcus pyogenes MGAS2096 4064670 YP_600173.1 CDS MGAS2096_Spy0577 NC_008023.1 550256 551758 D minor capsid protein 550256..551758 Streptococcus pyogenes MGAS2096 4064671 YP_600174.1 CDS MGAS2096_Spy0578 NC_008023.1 551763 553256 D minor capsid protein 551763..553256 Streptococcus pyogenes MGAS2096 4064672 YP_600175.1 CDS MGAS2096_Spy0579 NC_008023.1 553253 553483 D phage protein 553253..553483 Streptococcus pyogenes MGAS2096 4064673 YP_600176.1 CDS MGAS2096_Spy0580 NC_008023.1 553570 553836 D phage protein 553570..553836 Streptococcus pyogenes MGAS2096 4065176 YP_600177.1 CDS MGAS2096_Spy0581 NC_008023.1 553962 554576 D phage protein 553962..554576 Streptococcus pyogenes MGAS2096 4065177 YP_600178.1 CDS MGAS2096_Spy0582 NC_008023.1 554580 555398 D major head protein 554580..555398 Streptococcus pyogenes MGAS2096 4065178 YP_600179.1 CDS MGAS2096_Spy0583 NC_008023.1 555452 555868 D phage protein 555452..555868 Streptococcus pyogenes MGAS2096 4065179 YP_600180.1 CDS MGAS2096_Spy0584 NC_008023.1 555831 556190 D minor capsid protein 555831..556190 Streptococcus pyogenes MGAS2096 4065180 YP_600181.1 CDS MGAS2096_Spy0585 NC_008023.1 556190 556546 D minor capsid protein 556190..556546 Streptococcus pyogenes MGAS2096 4065181 YP_600182.1 CDS MGAS2096_Spy0586 NC_008023.1 556543 556941 D minor capsid protein 556543..556941 Streptococcus pyogenes MGAS2096 4065182 YP_600183.1 CDS MGAS2096_Spy0587 NC_008023.1 556941 557411 D major tail shaft protein 556941..557411 Streptococcus pyogenes MGAS2096 4065183 YP_600184.1 CDS MGAS2096_Spy0588 NC_008023.1 557464 557898 D phage protein 557464..557898 Streptococcus pyogenes MGAS2096 4065184 YP_600185.1 CDS MGAS2096_Spy0589 NC_008023.1 557902 558483 D phage protein 557902..558483 Streptococcus pyogenes MGAS2096 4065185 YP_600186.1 CDS MGAS2096_Spy0590 NC_008023.1 558452 561733 D phage protein 558452..561733 Streptococcus pyogenes MGAS2096 4065186 YP_600187.1 CDS MGAS2096_Spy0591 NC_008023.1 561730 562446 D phage protein 561730..562446 Streptococcus pyogenes MGAS2096 4065187 YP_600188.1 CDS MGAS2096_Spy0592 NC_008023.1 562443 564590 D phage endopeptidase 562443..564590 Streptococcus pyogenes MGAS2096 4065188 YP_600189.1 CDS MGAS2096_Spy0593 NC_008023.1 564587 565642 D hyaluronoglucosaminidase 564587..565642 Streptococcus pyogenes MGAS2096 4065189 YP_600190.1 CDS MGAS2096_Spy0594 NC_008023.1 565642 566277 D phage protein 565642..566277 Streptococcus pyogenes MGAS2096 4065190 YP_600191.1 CDS MGAS2096_Spy0595 NC_008023.1 566288 568195 D phage infection protein 566288..568195 Streptococcus pyogenes MGAS2096 4065191 YP_600192.1 CDS MGAS2096_Spy0596 NC_008023.1 568204 568365 D phage protein 568204..568365 Streptococcus pyogenes MGAS2096 4065192 YP_600193.1 CDS MGAS2096_Spy0597 NC_008023.1 568368 568988 D phage protein 568368..568988 Streptococcus pyogenes MGAS2096 4065193 YP_600194.1 CDS MGAS2096_Spy0598 NC_008023.1 568999 569298 D phage protein 568999..569298 Streptococcus pyogenes MGAS2096 4065194 YP_600195.1 CDS MGAS2096_Spy0599 NC_008023.1 569295 569480 D phage protein 569295..569480 Streptococcus pyogenes MGAS2096 4064825 YP_600196.1 CDS MGAS2096_Spy0600 NC_008023.1 569591 570787 D phage-associated cell wall hydrolase 569591..570787 Streptococcus pyogenes MGAS2096 4064826 YP_600197.1 CDS speA2 NC_008023.1 570855 571562 R enterotoxin complement(570855..571562) Streptococcus pyogenes MGAS2096 4064827 YP_600198.1 CDS spd3 NC_008023.1 571673 572431 R streptodornase complement(571673..572431) Streptococcus pyogenes MGAS2096 4064828 YP_600199.1 CDS pepD NC_008023.1 572743 574161 D dipeptidase A 572743..574161 Streptococcus pyogenes MGAS2096 4064829 YP_600200.1 CDS MGAS2096_Spy0604 NC_008023.1 574313 575860 D high-affinity zinc uptake system protein ZnuA 574313..575860 Streptococcus pyogenes MGAS2096 4064830 YP_600201.1 CDS MGAS2096_Spy0605 NC_008023.1 575999 576730 D GntR family transcriptional regulator 575999..576730 Streptococcus pyogenes MGAS2096 4064831 YP_600202.1 CDS agaS NC_008023.1 576750 577949 D galactosamine-6-phosphate deaminase 576750..577949 Streptococcus pyogenes MGAS2096 4064832 YP_600203.1 CDS rpmE2 NC_008023.1 578046 578306 R RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 complement(578046..578306) Streptococcus pyogenes MGAS2096 4064833 YP_600204.1 CDS MGAS2096_Spy0608 NC_008023.1 578421 579254 R phosphoesterase, DHH family protein complement(578421..579254) Streptococcus pyogenes MGAS2096 4064834 YP_600205.1 CDS MGAS2096_Spy0609 NC_008023.1 579741 580202 D An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 579741..580202 Streptococcus pyogenes MGAS2096 4064835 YP_600206.1 CDS MGAS2096_Spy0610 NC_008023.1 580377 580661 D hypothetical protein 580377..580661 Streptococcus pyogenes MGAS2096 4064836 YP_600207.1 CDS MGAS2096_Spy0611 NC_008023.1 580642 581916 D chloride channel protein 580642..581916 Streptococcus pyogenes MGAS2096 4064837 YP_600208.1 CDS rplS NC_008023.1 582031 582378 D this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 582031..582378 Streptococcus pyogenes MGAS2096 4064838 YP_600209.1 CDS int2 NC_008023.1 582739 582954 R DNA integration/recombination/inversion protein complement(582739..582954) Streptococcus pyogenes MGAS2096 4064840 YP_600210.1 CDS MGAS2096_Spy0614 NC_008023.1 583392 583961 D phosphatase 583392..583961 Streptococcus pyogenes MGAS2096 4064841 YP_600211.1 CDS gyrB NC_008023.1 583962 585917 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 583962..585917 Streptococcus pyogenes MGAS2096 4064842 YP_600212.1 CDS MGAS2096_Spy0616 NC_008023.1 586309 588033 D acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation; septation ring formation regulator EzrA 586309..588033 Streptococcus pyogenes MGAS2096 4064843 YP_600213.1 CDS MGAS2096_Spy0617 NC_008023.1 588165 588623 R putative cytoplasmic protein complement(588165..588623) Streptococcus pyogenes MGAS2096 4066157 YP_600214.1 CDS eno NC_008023.1 588856 590163 D enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 588856..590163 Streptococcus pyogenes MGAS2096 4066158 YP_600215.1 CDS MGAS2096_Spy0619 NC_008023.1 590752 591327 R transposase complement(590752..591327) Streptococcus pyogenes MGAS2096 4066159 YP_600216.1 CDS MGAS2096_Spy0620 NC_008023.1 591413 591574 R transposase complement(591413..591574) Streptococcus pyogenes MGAS2096 4066160 YP_600217.1 CDS MGAS2096_Spy0621 NC_008023.1 591936 592484 R transcriptional regulator complement(591936..592484) Streptococcus pyogenes MGAS2096 4066161 YP_600218.1 CDS epf NC_008023.1 592529 597796 D extracellular matrix binding protein 592529..597796 Streptococcus pyogenes MGAS2096 4066162 YP_600219.1 CDS sagA NC_008023.1 598660 598821 D streptolysin S 598660..598821 Streptococcus pyogenes MGAS2096 4066163 YP_600220.1 CDS sagB NC_008023.1 599043 599993 D streptolysin S biosynthesis protein SagB 599043..599993 Streptococcus pyogenes MGAS2096 4066164 YP_600221.1 CDS sagC NC_008023.1 599990 601048 D streptolysin S biosynthesis protein SagC 599990..601048 Streptococcus pyogenes MGAS2096 4066165 YP_600222.1 CDS sagD NC_008023.1 601068 602426 D streptolysin S biosynthesis protein SagD 601068..602426 Streptococcus pyogenes MGAS2096 4066166 YP_600223.1 CDS sagE NC_008023.1 602401 603072 D streptolysin S putative self-immunity protein SagE 602401..603072 Streptococcus pyogenes MGAS2096 4066167 YP_600224.1 CDS sagF NC_008023.1 603069 603752 D streptolysin S biosynthesis protein SagF 603069..603752 Streptococcus pyogenes MGAS2096 4066168 YP_600225.1 CDS sagG NC_008023.1 603775 604698 D streptolysin S export ATP-binding protein SagG 603775..604698 Streptococcus pyogenes MGAS2096 4066169 YP_600226.1 CDS sagH NC_008023.1 604707 605834 D streptolysin S export transmembrane protein SagH 604707..605834 Streptococcus pyogenes MGAS2096 4066170 YP_600227.1 CDS sagI NC_008023.1 605831 606949 D streptolysin S export transmembrane protein SagI 605831..606949 Streptococcus pyogenes MGAS2096 4066171 YP_600228.1 CDS MGAS2096_Spy0632 NC_008023.1 607060 607287 R hypothetical protein complement(607060..607287) Streptococcus pyogenes MGAS2096 4066172 YP_600229.1 CDS MGAS2096_Spy0633 NC_008023.1 607529 610261 D endonuclease/exonuclease/phosphatase family protein 607529..610261 Streptococcus pyogenes MGAS2096 4066173 YP_600230.1 CDS MGAS2096_Spy0634 NC_008023.1 610539 611039 D hypothetical protein 610539..611039 Streptococcus pyogenes MGAS2096 4066174 YP_600231.1 CDS ligA NC_008023.1 611233 613191 D this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 611233..613191 Streptococcus pyogenes MGAS2096 4066175 YP_600232.1 CDS MGAS2096_Spy0636 NC_008023.1 613205 614227 D similar to YegS from E. coli; putative lipid kinase 613205..614227 Streptococcus pyogenes MGAS2096 4064771 YP_600233.1 CDS atpE NC_008023.1 614619 614816 D produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 614619..614816 Streptococcus pyogenes MGAS2096 4064772 YP_600234.1 CDS atpB NC_008023.1 614851 615567 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 614851..615567 Streptococcus pyogenes MGAS2096 4064773 YP_600235.1 CDS atpF NC_008023.1 615585 616079 D Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 615585..616079 Streptococcus pyogenes MGAS2096 4064774 YP_600236.1 CDS atpH NC_008023.1 616079 616615 D Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 616079..616615 Streptococcus pyogenes MGAS2096 4064775 YP_600237.1 CDS atpA NC_008023.1 616631 618139 D produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 616631..618139 Streptococcus pyogenes MGAS2096 4064776 YP_600238.1 CDS atpG NC_008023.1 618155 619030 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 618155..619030 Streptococcus pyogenes MGAS2096 4064777 YP_600239.1 CDS atpD NC_008023.1 619192 620598 D Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 619192..620598 Streptococcus pyogenes MGAS2096 4064778 YP_600240.1 CDS atpC NC_008023.1 620611 621027 D part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 620611..621027 Streptococcus pyogenes MGAS2096 4064779 YP_600241.1 CDS MGAS2096_Spy0645 NC_008023.1 621293 621550 D hypothetical protein 621293..621550 Streptococcus pyogenes MGAS2096 4064780 YP_600242.1 CDS murA NC_008023.1 621615 622886 D adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 621615..622886 Streptococcus pyogenes MGAS2096 4064781 YP_600243.1 CDS epuA NC_008023.1 622890 623078 D EpuA protein 622890..623078 Streptococcus pyogenes MGAS2096 4064782 YP_600244.1 CDS endA NC_008023.1 623114 623653 D DNA-entry nuclease 623114..623653 Streptococcus pyogenes MGAS2096 4064783 YP_600245.2 CDS pheS NC_008023.1 623936 624979 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 623936..624979 Streptococcus pyogenes MGAS2096 4064784 YP_600246.1 CDS pheT NC_008023.1 625174 627594 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 625174..627594 Streptococcus pyogenes MGAS2096 4064785 YP_600247.1 CDS MGAS2096_Spy0651 NC_008023.1 627668 628081 D Salt-stress induced protein 627668..628081 Streptococcus pyogenes MGAS2096 4064786 YP_600248.1 CDS MGAS2096_Spy0652 NC_008023.1 628074 628460 D hypothetical protein 628074..628460 Streptococcus pyogenes MGAS2096 4064787 YP_600249.1 CDS MGAS2096_Spy0653 NC_008023.1 628533 629195 D ABC transporter permease 628533..629195 Streptococcus pyogenes MGAS2096 4064788 YP_600250.1 CDS MGAS2096_Spy0654 NC_008023.1 629305 629607 D ABC transporter permease 629305..629607 Streptococcus pyogenes MGAS2096 4064789 YP_600251.1 CDS MGAS2096_Spy0655 NC_008023.1 629614 630285 D ABC transporter ATP-binding protein 629614..630285 Streptococcus pyogenes MGAS2096 4064790 YP_600252.1 CDS MGAS2096_Spy0656 NC_008023.1 630389 631306 R neutral zinc metallopeptidase family protein complement(630389..631306) Streptococcus pyogenes MGAS2096 4064538 YP_600253.1 CDS rexB NC_008023.1 631457 634672 D ATP-dependent nuclease subunit B 631457..634672 Streptococcus pyogenes MGAS2096 4064539 YP_600254.1 CDS rexA NC_008023.1 634633 637224 D ATP-dependent nuclease subunit A 634633..637224 Streptococcus pyogenes MGAS2096 4064540 YP_600255.1 CDS MGAS2096_Spy0659 NC_008023.1 637227 638300 D ATP-dependent nuclease subunit A 637227..638300 Streptococcus pyogenes MGAS2096 4064541 YP_600256.1 CDS MGAS2096_Spy0660 NC_008023.1 638416 639252 D arginine-binding protein 638416..639252 Streptococcus pyogenes MGAS2096 4064542 YP_600257.2 CDS rpsU NC_008023.1 639393 639569 D a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 639393..639569 Streptococcus pyogenes MGAS2096 4064543 YP_600258.1 CDS mscL NC_008023.1 639697 640059 R large-conductance mechanosensitive channel complement(639697..640059) Streptococcus pyogenes MGAS2096 4064544 YP_600259.1 CDS dnaG NC_008023.1 640189 642003 D synthesizes RNA primers at the replication forks; DNA primase 640189..642003 Streptococcus pyogenes MGAS2096 4064545 YP_600260.1 CDS rpoD NC_008023.1 642012 643121 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium; RNA polymerase sigma factor RpoD 642012..643121 Streptococcus pyogenes MGAS2096 4064546 YP_600261.1 CDS MGAS2096_Spy0665 NC_008023.1 643357 643695 D putative cytoplasmic protein 643357..643695 Streptococcus pyogenes MGAS2096 4064547 YP_600262.1 CDS rmlD NC_008023.1 643773 644687 D dTDP-4-dehydrorhamnose reductase 643773..644687 Streptococcus pyogenes MGAS2096 4064548 YP_600263.1 CDS MGAS2096_Spy0667 NC_008023.1 644639 644758 D hypothetical protein 644639..644758 Streptococcus pyogenes MGAS2096 4064549 YP_600264.1 CDS rgpAc NC_008023.1 644806 645960 D alpha-D-GlcNAc alpha-1,2-L-rhamnosyltransferase 644806..645960 Streptococcus pyogenes MGAS2096 4064550 YP_600265.1 CDS rgpBc NC_008023.1 645950 646882 D alpha-L-Rha alpha-1,3-L-rhamnosyltransferase 645950..646882 Streptococcus pyogenes MGAS2096 4064551 YP_600266.1 CDS rgpCc NC_008023.1 646885 647688 D polysaccharide ABC transporter permease 646885..647688 Streptococcus pyogenes MGAS2096 4064552 YP_600267.1 CDS rgpDc NC_008023.1 647688 648893 D polysaccharide export ATP-binding protein 647688..648893 Streptococcus pyogenes MGAS2096 4064553 YP_600268.1 CDS rgpEc NC_008023.1 648918 649925 D glycosyltransferase 648918..649925 Streptococcus pyogenes MGAS2096 4064554 YP_600269.1 CDS rgpFc NC_008023.1 649922 651667 D bifunctional; alpha-L-Rha alpha-1,2-L-rhamnosyltransferase / alpha-L-Rha alpha-1,3-L-rhamnosyltransferase 649922..651667 Streptococcus pyogenes MGAS2096 4064555 YP_600270.1 CDS MGAS2096_Spy0674 NC_008023.1 651664 654138 D phosphoglycerol transferase 651664..654138 Streptococcus pyogenes MGAS2096 4064556 YP_600271.1 CDS MGAS2096_Spy0675 NC_008023.1 654317 655012 D cell wall biosynthesis glycosyltransferase 654317..655012 Streptococcus pyogenes MGAS2096 4064903 YP_600272.1 CDS MGAS2096_Spy0676 NC_008023.1 655014 655355 D hypothetical protein 655014..655355 Streptococcus pyogenes MGAS2096 4064904 YP_600273.1 CDS amrA NC_008023.1 655348 656634 D transcriptional activator amrA 655348..656634 Streptococcus pyogenes MGAS2096 4064905 YP_600274.1 CDS MGAS2096_Spy0678 NC_008023.1 656615 658111 D hypothetical protein 656615..658111 Streptococcus pyogenes MGAS2096 4064906 YP_600275.1 CDS pepT NC_008023.1 658193 659428 D catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 658193..659428 Streptococcus pyogenes MGAS2096 4064907 YP_600276.1 CDS ebsA NC_008023.1 659469 659957 D pore forming protein ebsA 659469..659957 Streptococcus pyogenes MGAS2096 4064908 YP_600277.1 CDS MGAS2096_Spy0681 NC_008023.1 659944 660141 R ferredoxin complement(659944..660141) Streptococcus pyogenes MGAS2096 4064909 YP_600278.1 CDS MGAS2096_Spy0682 NC_008023.1 660190 660666 D hypothetical protein 660190..660666 Streptococcus pyogenes MGAS2096 4064910 YP_600279.1 CDS cmk NC_008023.1 660681 661361 D Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 660681..661361 Streptococcus pyogenes MGAS2096 4064911 YP_600280.1 CDS infC NC_008023.1 661523 662053 D IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 661523..662053 Streptococcus pyogenes MGAS2096 4064912 YP_600281.1 CDS rpmI NC_008023.1 662095 662292 D 50S ribosomal protein L35 662095..662292 Streptococcus pyogenes MGAS2096 4064913 YP_600282.1 CDS rplT NC_008023.1 662351 662710 D binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 662351..662710 Streptococcus pyogenes MGAS2096 4064914 YP_600283.1 CDS MGAS2096_Spy0687 NC_008023.1 663001 665217 R sulfatase family protein complement(663001..665217) Streptococcus pyogenes MGAS2096 4064915 YP_600284.1 CDS MGAS2096_Spy0688 NC_008023.1 665319 666482 D methyltransferase 665319..666482 Streptococcus pyogenes MGAS2096 4064916 YP_600285.1 CDS aroD NC_008023.1 666479 667165 D catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 666479..667165 Streptococcus pyogenes MGAS2096 4064917 YP_600286.1 CDS aroF NC_008023.1 667259 668425 D catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 667259..668425 Streptococcus pyogenes MGAS2096 4064918 YP_600287.1 CDS MGAS2096_Spy0691 NC_008023.1 668486 668827 D hypothetical protein 668486..668827 Streptococcus pyogenes MGAS2096 4064919 YP_600288.1 CDS gor NC_008023.1 669039 670400 D catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 669039..670400 Streptococcus pyogenes MGAS2096 4064920 YP_600289.1 CDS folC2 NC_008023.1 670488 671780 R bifunctional; folylpolyglutamate synthase / dihydrofolate synthase complement(670488..671780) Streptococcus pyogenes MGAS2096 4064921 YP_600290.1 CDS MGAS2096_Spy0694 NC_008023.1 671786 672247 R hypothetical protein complement(671786..672247) Streptococcus pyogenes MGAS2096 4064922 YP_600291.1 CDS nifS1 NC_008023.1 672461 673603 D bifunctional; cysteine desulfurase / selenocysteine lyase 672461..673603 Streptococcus pyogenes MGAS2096 4065303 YP_600292.1 CDS thiI NC_008023.1 673615 674829 D Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 673615..674829 Streptococcus pyogenes MGAS2096 4065304 YP_600293.1 CDS capA NC_008023.1 674867 675739 D capsule biosynthesis protein capA 674867..675739 Streptococcus pyogenes MGAS2096 4065305 YP_600294.1 CDS MGAS2096_Spy0698 NC_008023.1 675736 676161 D capsule biosynthesis protein capA 675736..676161 Streptococcus pyogenes MGAS2096 4065306 YP_600295.1 CDS rplU NC_008023.1 676375 676689 D 50S ribosomal protein L21 676375..676689 Streptococcus pyogenes MGAS2096 4065307 YP_600296.1 CDS MGAS2096_Spy0700 NC_008023.1 676701 677027 D hypothetical protein 676701..677027 Streptococcus pyogenes MGAS2096 4065308 YP_600297.1 CDS rpmA NC_008023.1 677055 677348 D involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 677055..677348 Streptococcus pyogenes MGAS2096 4065309 YP_600298.1 CDS MGAS2096_Spy0702 NC_008023.1 677696 678613 D LysR family transcriptional regulator 677696..678613 Streptococcus pyogenes MGAS2096 4065310 YP_600299.1 CDS lsp NC_008023.1 678610 679068 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 678610..679068 Streptococcus pyogenes MGAS2096 4065311 YP_600300.1 CDS MGAS2096_Spy0704 NC_008023.1 679058 679252 D ribosomal large subunit pseudouridine synthase D 679058..679252 Streptococcus pyogenes MGAS2096 4065312 YP_600301.1 CDS MGAS2096_Spy0705 NC_008023.1 679276 679947 D ribosomal large subunit pseudouridine synthase D 679276..679947 Streptococcus pyogenes MGAS2096 4065313 YP_600302.1 CDS pyrR NC_008023.1 680343 680864 D regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 680343..680864 Streptococcus pyogenes MGAS2096 4065314 YP_600303.1 CDS pyrP NC_008023.1 680880 682139 D Uracil permease 680880..682139 Streptococcus pyogenes MGAS2096 4065315 YP_600304.1 CDS pyrB NC_008023.1 682146 683135 D catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit 682146..683135 Streptococcus pyogenes MGAS2096 4065316 YP_600305.1 CDS carA NC_008023.1 683179 684261 D catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 683179..684261 Streptococcus pyogenes MGAS2096 4065317 YP_600306.1 CDS MGAS2096_Spy0710 NC_008023.1 684233 684430 D hypothetical protein 684233..684430 Streptococcus pyogenes MGAS2096 4065318 YP_600307.2 CDS carB NC_008023.1 684507 687683 D four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 684507..687683 Streptococcus pyogenes MGAS2096 4065319 YP_600308.1 CDS MGAS2096_Spy0712 NC_008023.1 687889 689160 D periplasmic protein of efflux system 687889..689160 Streptococcus pyogenes MGAS2096 4065320 YP_600309.1 CDS MGAS2096_Spy0713 NC_008023.1 689160 689870 D ABC transporter ATP-binding protein 689160..689870 Streptococcus pyogenes MGAS2096 4065321 YP_600310.1 CDS MGAS2096_Spy0714 NC_008023.1 689882 691102 D ABC transporter permease 689882..691102 Streptococcus pyogenes MGAS2096 4066137 YP_600311.1 CDS MGAS2096_Spy0715 NC_008023.1 691314 693089 D hypothetical protein 691314..693089 Streptococcus pyogenes MGAS2096 4066138 YP_600312.1 CDS rpsP NC_008023.1 693216 693488 D binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 693216..693488 Streptococcus pyogenes MGAS2096 4066139 YP_600313.1 CDS MGAS2096_Spy0717 NC_008023.1 693498 693737 D RNA binding protein 693498..693737 Streptococcus pyogenes MGAS2096 4066140 YP_600314.1 CDS MGAS2096_Spy0718 NC_008023.1 693746 693853 D hypothetical protein 693746..693853 Streptococcus pyogenes MGAS2096 4066141 YP_600315.1 CDS MGAS2096_Spy0719 NC_008023.1 694669 697695 D cell surface protein 694669..697695 Streptococcus pyogenes MGAS2096 4066142 YP_600316.1 CDS MGAS2096_Spy0720 NC_008023.1 697715 698116 D putative cytoplasmic protein 697715..698116 Streptococcus pyogenes MGAS2096 4066143 YP_600317.1 CDS czcD NC_008023.1 698310 699185 R cobalt-zinc-cadmium resistance protein czcD complement(698310..699185) Streptococcus pyogenes MGAS2096 4066144 YP_600318.1 CDS MGAS2096_Spy0722 NC_008023.1 699312 699842 D TetR family transcriptional regulator 699312..699842 Streptococcus pyogenes MGAS2096 4066145 YP_600319.1 CDS MGAS2096_Spy0723 NC_008023.1 700057 700308 D 16S rRNA processing protein rimM 700057..700308 Streptococcus pyogenes MGAS2096 4066146 YP_600320.1 CDS rimM NC_008023.1 700263 700574 D 16S rRNA processing protein rimM 700263..700574 Streptococcus pyogenes MGAS2096 4066147 YP_600321.1 CDS trmD NC_008023.1 700564 701040 D tRNA (guanine-N(1)-)-methyltransferase 700564..701040 Streptococcus pyogenes MGAS2096 4066148 YP_600322.1 CDS MGAS2096_Spy0726 NC_008023.1 701024 701284 D tRNA (guanine-N(1)-)-methyltransferase 701024..701284 Streptococcus pyogenes MGAS2096 4066149 YP_600323.1 CDS trxB NC_008023.1 701296 702288 D thioredoxin reductase 701296..702288 Streptococcus pyogenes MGAS2096 4066150 YP_600324.1 CDS MGAS2096_Spy0728 NC_008023.1 702464 703522 D hypothetical protein 702464..703522 Streptococcus pyogenes MGAS2096 4066151 YP_600325.1 CDS apbA NC_008023.1 703535 704458 D ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 703535..704458 Streptococcus pyogenes MGAS2096 4066152 YP_600326.1 CDS fruR NC_008023.1 704714 705427 D fructose repressor 704714..705427 Streptococcus pyogenes MGAS2096 4066153 YP_600327.1 CDS fruB NC_008023.1 705424 705906 D 1-phosphofructokinase 705424..705906 Streptococcus pyogenes MGAS2096 4066154 YP_600328.1 CDS MGAS2096_Spy0732 NC_008023.1 705887 706336 D 1-phosphofructokinase 705887..706336 Streptococcus pyogenes MGAS2096 4066155 YP_600329.1 CDS fruA NC_008023.1 706333 708279 D PTS system fructose-specific transporter subunit IIABC 706333..708279 Streptococcus pyogenes MGAS2096 4066156 YP_600330.1 CDS mur1-1 NC_008023.1 708372 708971 D N-acetylmuramidase 708372..708971 Streptococcus pyogenes MGAS2096 4066098 YP_600331.1 CDS mur1-2 NC_008023.1 709123 709830 D N-acetylmuramidase 709123..709830 Streptococcus pyogenes MGAS2096 4066099 YP_600332.1 CDS MGAS2096_Spy0736 NC_008023.1 709887 710105 R transposase complement(709887..710105) Streptococcus pyogenes MGAS2096 4066100 YP_600333.1 CDS MGAS2096_Spy0737 NC_008023.1 710308 710427 R hypothetical protein complement(710308..710427) Streptococcus pyogenes MGAS2096 4066101 YP_600334.1 CDS MGAS2096_Spy0738 NC_008023.1 710402 710614 R exotoxin type C complement(710402..710614) Streptococcus pyogenes MGAS2096 4066102 YP_600335.1 CDS mac NC_008023.1 710787 711812 R hypothetical protein complement(710787..711812) Streptococcus pyogenes MGAS2096 4066103 YP_600336.1 CDS MGAS2096_Spy0740 NC_008023.1 711968 712087 D phage protein 711968..712087 Streptococcus pyogenes MGAS2096 4066104 YP_600337.1 CDS MGAS2096_Spy0741 NC_008023.1 712312 712488 D nucleoside diphosphate kinase 712312..712488 Streptococcus pyogenes MGAS2096 4066105 YP_600338.1 CDS MGAS2096_Spy0742 NC_008023.1 712716 713096 D putative cytoplasmic protein 712716..713096 Streptococcus pyogenes MGAS2096 4066106 YP_600339.1 CDS MGAS2096_Spy0743 NC_008023.1 713096 713944 D DegV family protein 713096..713944 Streptococcus pyogenes MGAS2096 4066107 YP_600340.1 CDS papS NC_008023.1 714069 715277 D catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase 714069..715277 Streptococcus pyogenes MGAS2096 4066108 YP_600341.1 CDS MGAS2096_Spy0745 NC_008023.1 715274 717151 D ABC transporter ATP-binding protein uup 715274..717151 Streptococcus pyogenes MGAS2096 4066109 YP_600342.1 CDS MGAS2096_Spy0746 NC_008023.1 717548 717673 D hypothetical protein 717548..717673 Streptococcus pyogenes MGAS2096 4066110 YP_600343.1 CDS MGAS2096_Spy0747 NC_008023.1 717567 717785 D hypothetical protein 717567..717785 Streptococcus pyogenes MGAS2096 4066111 YP_600344.1 CDS fms NC_008023.1 718041 718451 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 718041..718451 Streptococcus pyogenes MGAS2096 4066112 YP_600345.1 CDS MGAS2096_Spy0749 NC_008023.1 718533 720584 R 5'-nucleotidase complement(718533..720584) Streptococcus pyogenes MGAS2096 4066113 YP_600346.1 CDS MGAS2096_Spy0750 NC_008023.1 720765 721415 D GTP pyrophosphokinase 720765..721415 Streptococcus pyogenes MGAS2096 4066114 YP_600347.1 CDS sptR NC_008023.1 721418 722086 D two-component response regulator 721418..722086 Streptococcus pyogenes MGAS2096 4066115 YP_600348.1 CDS sptS NC_008023.1 722068 723327 D two-component system histidine kinase 722068..723327 Streptococcus pyogenes MGAS2096 4066116 YP_600349.1 CDS mvaK1 NC_008023.1 723631 724509 D mevalonate kinase 723631..724509 Streptococcus pyogenes MGAS2096 4066078 YP_600350.1 CDS mvaD NC_008023.1 724491 725435 D diphosphomevalonate decarboxylase 724491..725435 Streptococcus pyogenes MGAS2096 4066079 YP_600351.1 CDS mvaK2 NC_008023.1 725380 726441 D phosphomevalonate kinase 725380..726441 Streptococcus pyogenes MGAS2096 4066080 YP_600352.1 CDS MGAS2096_Spy0756 NC_008023.1 726338 727417 D catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase 726338..727417 Streptococcus pyogenes MGAS2096 4066081 YP_600353.1 CDS MGAS2096_Spy0757 NC_008023.1 727580 728443 D transposase 727580..728443 Streptococcus pyogenes MGAS2096 4066082 YP_600354.1 CDS MGAS2096_Spy0758 NC_008023.1 728615 729892 R bifunctional; 3-hydroxy-3-methylglutaryl-coenzyme A reductase / 3-hydroxy-3-methylglutaryl-coenzyme A reductase complement(728615..729892) Streptococcus pyogenes MGAS2096 4066083 YP_600355.1 CDS mvaS1 NC_008023.1 729879 731093 R hydroxymethylglutaryl-CoA synthase complement(729879..731093) Streptococcus pyogenes MGAS2096 4066084 YP_600356.1 CDS thyA NC_008023.1 731239 732102 D ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 731239..732102 Streptococcus pyogenes MGAS2096 4066085 YP_600357.1 CDS dyr NC_008023.1 732182 732679 D dihydrofolate reductase 732182..732679 Streptococcus pyogenes MGAS2096 4066086 YP_600358.1 CDS MGAS2096_Spy0762 NC_008023.1 732699 732869 D hypothetical protein 732699..732869 Streptococcus pyogenes MGAS2096 4066087 YP_600359.1 CDS clpX NC_008023.1 732999 734228 D binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 732999..734228 Streptococcus pyogenes MGAS2096 4066088 YP_600360.1 CDS engB NC_008023.1 734238 734837 D binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 734238..734837 Streptococcus pyogenes MGAS2096 4066089 YP_600361.1 CDS MGAS2096_Spy0765 NC_008023.1 734985 735728 D hypothetical protein 734985..735728 Streptococcus pyogenes MGAS2096 4066090 YP_600362.1 CDS clpL NC_008023.1 735786 737885 R ATP-dependent endopeptidase Clp ATP-binding subunit clpL complement(735786..737885) Streptococcus pyogenes MGAS2096 4066091 YP_600363.1 CDS rpiA NC_008023.1 738263 738946 D Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 738263..738946 Streptococcus pyogenes MGAS2096 4066092 YP_600364.1 CDS deoB NC_008023.1 739023 740234 D catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 739023..740234 Streptococcus pyogenes MGAS2096 4066093 YP_600365.1 CDS arsC NC_008023.1 740247 740693 D arsenate reductase 740247..740693 Streptococcus pyogenes MGAS2096 4066094 YP_600366.1 CDS punA NC_008023.1 740677 741486 D catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 740677..741486 Streptococcus pyogenes MGAS2096 4066095 YP_600367.1 CDS deoD NC_008023.1 742149 742862 D catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 742149..742862 Streptococcus pyogenes MGAS2096 4066096 YP_600368.1 CDS cpsX NC_008023.1 742849 743643 D histidine protein kinase 742849..743643 Streptococcus pyogenes MGAS2096 4066097 YP_600369.1 CDS cpsY NC_008023.1 743723 744628 R LysR family transcriptional regulator complement(743723..744628) Streptococcus pyogenes MGAS2096 4066061 YP_600370.1 CDS MGAS2096_Spy0774 NC_008023.1 744850 745386 D hypothetical protein 744850..745386 Streptococcus pyogenes MGAS2096 4066062 YP_600371.1 CDS pyrF NC_008023.1 745663 746355 D type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 745663..746355 Streptococcus pyogenes MGAS2096 4066063 YP_600372.1 CDS pyrE NC_008023.1 746413 747042 D involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 746413..747042 Streptococcus pyogenes MGAS2096 4066064 YP_600373.1 CDS amiC NC_008023.1 747239 748693 D catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 747239..748693 Streptococcus pyogenes MGAS2096 4066065 YP_600374.1 CDS MGAS2096_Spy0778 NC_008023.1 748775 749674 D cystine-binding protein 748775..749674 Streptococcus pyogenes MGAS2096 4066066 YP_600375.1 CDS MGAS2096_Spy0779 NC_008023.1 749703 750353 D cystine transport system permease 749703..750353 Streptococcus pyogenes MGAS2096 4066067 YP_600376.1 CDS ung NC_008023.1 750486 751139 D Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 750486..751139 Streptococcus pyogenes MGAS2096 4066068 YP_600377.1 CDS pyrC NC_008023.1 751271 752539 D catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 751271..752539 Streptococcus pyogenes MGAS2096 4066069 YP_600378.1 CDS MGAS2096_Spy0782 NC_008023.1 752597 753319 R involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; putative glycerol-3-phosphate acyltransferase PlsY complement(752597..753319) Streptococcus pyogenes MGAS2096 4066070 YP_600379.1 CDS parE NC_008023.1 753370 755322 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 753370..755322 Streptococcus pyogenes MGAS2096 4066071 YP_600380.1 CDS parC NC_008023.1 755407 757872 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 755407..757872 Streptococcus pyogenes MGAS2096 4066072 YP_600381.1 CDS bcaT NC_008023.1 757950 759005 D catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 757950..759005 Streptococcus pyogenes MGAS2096 4066073 YP_600382.1 CDS MGAS2096_Spy0786 NC_008023.1 759077 759301 D putative cytoplasmic protein 759077..759301 Streptococcus pyogenes MGAS2096 4066074 YP_600383.1 CDS rpsA NC_008023.1 759700 760905 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 759700..760905 Streptococcus pyogenes MGAS2096 4066077 YP_600384.1 CDS MGAS2096_Spy0788 NC_008023.1 761452 761754 R hypothetical protein complement(761452..761754) Streptococcus pyogenes MGAS2096 4066043 YP_600385.1 CDS MGAS2096_Spy0789 NC_008023.1 761954 762940 D hypothetical protein 761954..762940 Streptococcus pyogenes MGAS2096 4066044 YP_600386.1 CDS MGAS2096_Spy0790 NC_008023.1 763011 763202 D hypothetical protein 763011..763202 Streptococcus pyogenes MGAS2096 4066045 YP_600387.1 CDS MGAS2096_Spy0791 NC_008023.1 763335 763637 D glutathione S-transferase 763335..763637 Streptococcus pyogenes MGAS2096 4066046 YP_600388.1 CDS MGAS2096_Spy0792 NC_008023.1 763937 764608 D putative exfoliative toxin 763937..764608 Streptococcus pyogenes MGAS2096 4066047 YP_600389.1 CDS MGAS2096_Spy0793 NC_008023.1 764721 764903 R hypothetical protein complement(764721..764903) Streptococcus pyogenes MGAS2096 4066048 YP_600390.1 CDS miaA NC_008023.1 765037 765936 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 765037..765936 Streptococcus pyogenes MGAS2096 4066049 YP_600391.1 CDS hflX NC_008023.1 765997 767247 D GTP-binding protein hflX 765997..767247 Streptococcus pyogenes MGAS2096 4066050 YP_600392.1 CDS MGAS2096_Spy0796 NC_008023.1 767228 767875 D hypothetical protein 767228..767875 Streptococcus pyogenes MGAS2096 4066051 YP_600393.1 CDS elaC NC_008023.1 767890 768819 D member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 767890..768819 Streptococcus pyogenes MGAS2096 4066052 YP_600394.1 CDS MGAS2096_Spy0798 NC_008023.1 768819 769583 D short-chain dehydrogenase 768819..769583 Streptococcus pyogenes MGAS2096 4066053 YP_600395.1 CDS recJ NC_008023.1 769580 771790 D single-stranded-DNA-specific exonuclease recJ 769580..771790 Streptococcus pyogenes MGAS2096 4066054 YP_600396.1 CDS apt NC_008023.1 771941 772459 D catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 771941..772459 Streptococcus pyogenes MGAS2096 4066055 YP_600397.1 CDS dnaD NC_008023.1 772540 773223 D DNA replication protein dnaD 772540..773223 Streptococcus pyogenes MGAS2096 4066056 YP_600398.1 CDS nth NC_008023.1 773220 773876 D endonuclease III 773220..773876 Streptococcus pyogenes MGAS2096 4066057 YP_600399.1 CDS MGAS2096_Spy0803 NC_008023.1 773948 774634 D putative cytoplasmic protein 773948..774634 Streptococcus pyogenes MGAS2096 4066058 YP_600400.1 CDS MGAS2096_Spy0804 NC_008023.1 774618 774794 D NIF3-like protein 774618..774794 Streptococcus pyogenes MGAS2096 4066059 YP_600401.1 CDS MGAS2096_Spy0805 NC_008023.1 774883 775257 D NIF3-like protein 774883..775257 Streptococcus pyogenes MGAS2096 4066060 YP_600402.1 CDS MGAS2096_Spy0806 NC_008023.1 775191 775412 D NIF3-like protein 775191..775412 Streptococcus pyogenes MGAS2096 4066023 YP_600403.1 CDS MGAS2096_Spy0807 NC_008023.1 775447 776553 D glycine/D-amino acid oxidase family protein 775447..776553 Streptococcus pyogenes MGAS2096 4066024 YP_600404.1 CDS cpsFO NC_008023.1 776611 777480 D glucose-1-phosphate thymidylyltransferase 776611..777480 Streptococcus pyogenes MGAS2096 4066025 YP_600405.1 CDS MGAS2096_Spy0809 NC_008023.1 777480 777644 D dTDP-4-dehydrorhamnose 3,5-epimerase 777480..777644 Streptococcus pyogenes MGAS2096 4066026 YP_600406.1 CDS cpsFP NC_008023.1 777577 778071 D dTDP-4-dehydrorhamnose 3,5-epimerase 777577..778071 Streptococcus pyogenes MGAS2096 4066027 YP_600407.1 CDS cpsFQ NC_008023.1 778315 779355 D dTDP-glucose 4,6-dehydratase 778315..779355 Streptococcus pyogenes MGAS2096 4066028 YP_600408.1 CDS MGAS2096_Spy0812 NC_008023.1 779576 780052 D 7,8-dihydro-8-oxoguanine-triphosphatase 779576..780052 Streptococcus pyogenes MGAS2096 4066029 YP_600409.1 CDS MGAS2096_Spy0813 NC_008023.1 780110 781291 D hypothetical protein 780110..781291 Streptococcus pyogenes MGAS2096 4066030 YP_600410.1 CDS MGAS2096_Spy0814 NC_008023.1 781263 782528 D hypothetical protein 781263..782528 Streptococcus pyogenes MGAS2096 4066031 YP_600411.1 CDS fbp NC_008023.1 782587 784281 R fibronectin-binding protein / fibrinogen-binding protein complement(782587..784281) Streptococcus pyogenes MGAS2096 4066032 YP_600412.1 CDS MGAS2096_Spy0816 NC_008023.1 784286 784411 D hypothetical protein 784286..784411 Streptococcus pyogenes MGAS2096 4066033 YP_600413.1 CDS MGAS2096_Spy0817 NC_008023.1 784593 785591 D hypothetical protein 784593..785591 Streptococcus pyogenes MGAS2096 4066034 YP_600414.1 CDS MGAS2096_Spy0818 NC_008023.1 785924 786805 D ABC transporter permease 785924..786805 Streptococcus pyogenes MGAS2096 4066035 YP_600415.1 CDS MGAS2096_Spy0819 NC_008023.1 786802 787560 D ABC transporter ATP-binding protein 786802..787560 Streptococcus pyogenes MGAS2096 4066036 YP_600416.1 CDS MGAS2096_Spy0820 NC_008023.1 787764 789425 D Zn-dependent hydrolase 787764..789425 Streptococcus pyogenes MGAS2096 4066037 YP_600417.1 CDS estA NC_008023.1 789558 790343 D Acetyl esterase 789558..790343 Streptococcus pyogenes MGAS2096 4066038 YP_600418.1 CDS MGAS2096_Spy0822 NC_008023.1 790493 790699 D hypothetical protein 790493..790699 Streptococcus pyogenes MGAS2096 4066039 YP_600419.1 CDS MGAS2096_Spy0823 NC_008023.1 790745 792652 D ABC transporter ATP-binding protein 790745..792652 Streptococcus pyogenes MGAS2096 4066040 YP_600420.1 CDS acoA NC_008023.1 792927 793907 D pyruvate dehydrogenase E1 component alpha subunit 792927..793907 Streptococcus pyogenes MGAS2096 4066041 YP_600421.1 CDS acoB NC_008023.1 793963 794964 D pyruvate dehydrogenase E1 component beta subunit 793963..794964 Streptococcus pyogenes MGAS2096 4066003 YP_600422.1 CDS acoC NC_008023.1 795149 796558 D branched-chain alpha-keto acid dehydrogenase subunit E2 795149..796558 Streptococcus pyogenes MGAS2096 4066004 YP_600423.1 CDS MGAS2096_Spy0827 NC_008023.1 796613 796852 R hypothetical protein complement(796613..796852) Streptococcus pyogenes MGAS2096 4066005 YP_600424.1 CDS acoL NC_008023.1 796885 798648 D dihydrolipoamide dehydrogenase 796885..798648 Streptococcus pyogenes MGAS2096 4066006 YP_600425.1 CDS MGAS2096_Spy0829 NC_008023.1 798664 798891 R hypothetical protein complement(798664..798891) Streptococcus pyogenes MGAS2096 4066007 YP_600426.1 CDS hylA NC_008023.1 799322 801229 R hyaluronate lyase complement(799322..801229) Streptococcus pyogenes MGAS2096 4066008 YP_600427.1 CDS MGAS2096_Spy0831 NC_008023.1 801301 801807 R hyaluronate lyase complement(801301..801807) Streptococcus pyogenes MGAS2096 4066009 YP_600428.1 CDS lplB NC_008023.1 801971 802960 D lipoate-protein ligase A 801971..802960 Streptococcus pyogenes MGAS2096 4066010 YP_600429.1 CDS MGAS2096_Spy0833 NC_008023.1 803069 803860 R glutamine amidotransferase complement(803069..803860) Streptococcus pyogenes MGAS2096 4066011 YP_600430.1 CDS MGAS2096_Spy0834 NC_008023.1 803860 805203 R UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase complement(803860..805203) Streptococcus pyogenes MGAS2096 4066012 YP_600431.1 CDS MGAS2096_Spy0835 NC_008023.1 805310 806161 D hypothetical protein 805310..806161 Streptococcus pyogenes MGAS2096 4066013 YP_600432.1 CDS MGAS2096_Spy0836 NC_008023.1 806158 807114 D hypothetical protein 806158..807114 Streptococcus pyogenes MGAS2096 4066014 YP_600433.1 CDS glmM NC_008023.1 807168 808523 D catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 807168..808523 Streptococcus pyogenes MGAS2096 4066015 YP_600434.1 CDS MGAS2096_Spy0838 NC_008023.1 808647 809288 D hypothetical protein 808647..809288 Streptococcus pyogenes MGAS2096 4066016 YP_600435.1 CDS hemN NC_008023.1 809255 810481 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 809255..810481 Streptococcus pyogenes MGAS2096 4066017 YP_600436.1 CDS MGAS2096_Spy0840 NC_008023.1 810491 811243 D acyl-acyl-carrier protein thioesterase 810491..811243 Streptococcus pyogenes MGAS2096 4066018 YP_600437.1 CDS MGAS2096_Spy0841 NC_008023.1 811243 812007 D haloacid dehalogenase-like hydrolase 811243..812007 Streptococcus pyogenes MGAS2096 4066019 YP_600438.1 CDS MGAS2096_Spy0842 NC_008023.1 811995 812639 D hypothetical protein 811995..812639 Streptococcus pyogenes MGAS2096 4066020 YP_600439.1 CDS MGAS2096_Spy0843 NC_008023.1 813084 817190 D putative cytoplasmic protein 813084..817190 Streptococcus pyogenes MGAS2096 4066021 YP_600440.1 CDS MGAS2096_Spy0844 NC_008023.1 817190 818059 D putative cytoplasmic protein 817190..818059 Streptococcus pyogenes MGAS2096 4066022 YP_600441.1 CDS MGAS2096_Spy0845 NC_008023.1 818056 818397 D putative cytoplasmic protein 818056..818397 Streptococcus pyogenes MGAS2096 4065984 YP_600442.1 CDS MGAS2096_Spy0846 NC_008023.1 818321 819049 D hypothetical protein 818321..819049 Streptococcus pyogenes MGAS2096 4065985 YP_600443.1 CDS MGAS2096_Spy0847 NC_008023.1 819451 819630 D nucleoside diphosphate kinase 819451..819630 Streptococcus pyogenes MGAS2096 4065986 YP_600444.1 CDS MGAS2096_Spy0848 NC_008023.1 819694 819942 D nucleoside diphosphate kinase 819694..819942 Streptococcus pyogenes MGAS2096 4065987 YP_600445.1 CDS MGAS2096_Spy0849 NC_008023.1 819979 821121 D transposase 819979..821121 Streptococcus pyogenes MGAS2096 4065988 YP_600446.1 CDS lepA NC_008023.1 821290 823197 D binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 821290..823197 Streptococcus pyogenes MGAS2096 4065989 YP_600447.1 CDS MGAS2096_Spy0851 NC_008023.1 823442 824650 D collagen-like surface protein 823442..824650 Streptococcus pyogenes MGAS2096 4065990 YP_600448.1 CDS msrB NC_008023.1 824836 825273 D this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 824836..825273 Streptococcus pyogenes MGAS2096 4065991 YP_600449.1 CDS MGAS2096_Spy0853 NC_008023.1 825403 826422 D hypothetical protein 825403..826422 Streptococcus pyogenes MGAS2096 4065992 YP_600450.1 CDS MGAS2096_Spy0854 NC_008023.1 826629 827054 D PTS system mannose/fructose family IIA subunit 826629..827054 Streptococcus pyogenes MGAS2096 4065993 YP_600451.1 CDS ptsB NC_008023.1 827073 827564 D PTS system mannose/fructose family transporter subunit IIB 827073..827564 Streptococcus pyogenes MGAS2096 4065994 YP_600452.1 CDS ptsC NC_008023.1 827581 828390 D PTS system mannose/fructose family transporter subunit IIC 827581..828390 Streptococcus pyogenes MGAS2096 4065995 YP_600453.1 CDS ptsD NC_008023.1 828387 829214 D PTS system mannose/fructose family transporter subunit IID 828387..829214 Streptococcus pyogenes MGAS2096 4065996 YP_600454.1 CDS MGAS2096_Spy0858 NC_008023.1 829350 830999 D two-component sensor kinase yesM 829350..830999 Streptococcus pyogenes MGAS2096 4065997 YP_600455.1 CDS MGAS2096_Spy0859 NC_008023.1 831003 831791 D two-component response regulator yesN 831003..831791 Streptococcus pyogenes MGAS2096 4065998 YP_600456.1 CDS MGAS2096_Spy0860 NC_008023.1 831785 832831 D Iron(III)-binding protein 831785..832831 Streptococcus pyogenes MGAS2096 4065999 YP_600457.1 CDS gabD NC_008023.1 832943 834343 D succinate-semialdehyde dehydrogenase 832943..834343 Streptococcus pyogenes MGAS2096 4066000 YP_600458.1 CDS uvrC NC_008023.1 834445 836241 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 834445..836241 Streptococcus pyogenes MGAS2096 4066001 YP_600459.1 CDS MGAS2096_Spy0863 NC_008023.1 836425 837027 D NAD(P)H-dependent quinone reductase 836425..837027 Streptococcus pyogenes MGAS2096 4066002 YP_600460.2 CDS MGAS2096_Spy0864 NC_008023.1 837152 838561 D divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases; dipeptidase PepV 837152..838561 Streptococcus pyogenes MGAS2096 4065944 YP_600461.1 CDS thdF NC_008023.1 838629 839414 R tRNA (5-carboxymethylaminomethyl-2-thiouridylate) synthase complement(838629..839414) Streptococcus pyogenes MGAS2096 4065945 YP_600462.1 CDS MGAS2096_Spy0866 NC_008023.1 839359 840006 R tRNA (5-carboxymethylaminomethyl-2-thiouridylate) synthase complement(839359..840006) Streptococcus pyogenes MGAS2096 4065946 YP_600463.2 CDS rplJ NC_008023.1 840342 840842 D binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 840342..840842 Streptococcus pyogenes MGAS2096 4065947 YP_600464.1 CDS rplL NC_008023.1 840892 841272 D present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 840892..841272 Streptococcus pyogenes MGAS2096 4065948 YP_600465.1 CDS MGAS2096_Spy0869 NC_008023.1 841628 841768 D hypothetical protein 841628..841768 Streptococcus pyogenes MGAS2096 4065949 YP_600466.1 CDS MGAS2096_Spy0870 NC_008023.1 841762 842130 D hypothetical protein 841762..842130 Streptococcus pyogenes MGAS2096 4065950 YP_600467.1 CDS MGAS2096_Spy0871 NC_008023.1 842109 842246 D hypothetical protein 842109..842246 Streptococcus pyogenes MGAS2096 4065951 YP_600468.1 CDS MGAS2096_Spy0872 NC_008023.1 842296 842628 D DNA-cytosine methyltransferase 842296..842628 Streptococcus pyogenes MGAS2096 4065952 YP_600469.1 CDS MGAS2096_Spy0873 NC_008023.1 842686 842898 D relaxase 842686..842898 Streptococcus pyogenes MGAS2096 4065953 YP_600470.1 CDS MGAS2096_Spy0874 NC_008023.1 842941 843153 D relaxase 842941..843153 Streptococcus pyogenes MGAS2096 4065954 YP_600471.1 CDS MGAS2096_Spy0875 NC_008023.1 843418 843729 D relaxase 843418..843729 Streptococcus pyogenes MGAS2096 4065955 YP_600472.1 CDS srtI NC_008023.1 843798 844115 D relaxase 843798..844115 Streptococcus pyogenes MGAS2096 4065956 YP_600473.1 CDS srtR NC_008023.1 844266 844952 D two-component response regulator 844266..844952 Streptococcus pyogenes MGAS2096 4065957 YP_600474.1 CDS srtK NC_008023.1 844930 846291 D lantibiotic biosynthesis sensor protein 844930..846291 Streptococcus pyogenes MGAS2096 4065958 YP_600475.1 CDS srtT NC_008023.1 846703 848493 D lantibiotic ABC transporter permease 846703..848493 Streptococcus pyogenes MGAS2096 4065959 YP_600476.1 CDS MGAS2096_Spy0880 NC_008023.1 848465 849721 D lantibiotic biosynthesis; lanthionine synthetase 848465..849721 Streptococcus pyogenes MGAS2096 4065960 YP_600477.1 CDS MGAS2096_Spy0881 NC_008023.1 849740 852706 D lantibiotic biosynthesis; Serine (threonine) dehydratase 849740..852706 Streptococcus pyogenes MGAS2096 4065961 YP_600478.1 CDS srtF NC_008023.1 852655 853401 D lantibiotic ABC transporter ATP-binding protein 852655..853401 Streptococcus pyogenes MGAS2096 4065962 YP_600479.1 CDS srtE NC_008023.1 853407 854156 D lantibiotic ABC transporter permease 853407..854156 Streptococcus pyogenes MGAS2096 4065963 YP_600480.1 CDS srtG NC_008023.1 854159 854881 D lantibiotic ABC transporter permease 854159..854881 Streptococcus pyogenes MGAS2096 4065925 YP_600481.1 CDS MGAS2096_Spy0885 NC_008023.1 855072 855290 D Cro/CI family transcriptional regulator 855072..855290 Streptococcus pyogenes MGAS2096 4065926 YP_600482.1 CDS MGAS2096_Spy0886 NC_008023.1 855399 855614 R hypothetical protein complement(855399..855614) Streptococcus pyogenes MGAS2096 4065927 YP_600483.1 CDS MGAS2096_Spy0887 NC_008023.1 855814 855945 D DNA integration/recombination/inversion protein 855814..855945 Streptococcus pyogenes MGAS2096 4065928 YP_600484.1 CDS MGAS2096_Spy0888 NC_008023.1 855967 856188 D DNA integration/recombination/inversion protein 855967..856188 Streptococcus pyogenes MGAS2096 4065929 YP_600485.1 CDS MGAS2096_Spy0889 NC_008023.1 856261 856482 D DNA integration/recombination/inversion protein 856261..856482 Streptococcus pyogenes MGAS2096 4065930 YP_600486.1 CDS MGAS2096_Spy0890 NC_008023.1 856513 856896 D DNA integration/recombination/inversion protein 856513..856896 Streptococcus pyogenes MGAS2096 4065931 YP_600487.1 CDS dacA1 NC_008023.1 857039 858394 D D-alanyl-D-alanine serine-type carboxypeptidase 857039..858394 Streptococcus pyogenes MGAS2096 4065932 YP_600488.1 CDS MGAS2096_Spy0892 NC_008023.1 858511 859473 R polysaccharide deacetylase complement(858511..859473) Streptococcus pyogenes MGAS2096 4065933 YP_600489.1 CDS MGAS2096_Spy0893 NC_008023.1 859561 859716 D hypothetical protein 859561..859716 Streptococcus pyogenes MGAS2096 4065934 YP_600490.1 CDS folC1 NC_008023.1 859706 861082 D bifunctional; folylpolyglutamate synthase / dihydrofolate synthase 859706..861082 Streptococcus pyogenes MGAS2096 4065935 YP_600491.1 CDS folE NC_008023.1 861093 861701 D involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 861093..861701 Streptococcus pyogenes MGAS2096 4065936 YP_600492.1 CDS folP NC_008023.1 861710 862510 D dihydropteroate synthase 861710..862510 Streptococcus pyogenes MGAS2096 4065937 YP_600493.1 CDS folQ NC_008023.1 862517 862876 D dihydroneopterin aldolase 862517..862876 Streptococcus pyogenes MGAS2096 4065938 YP_600494.1 CDS folK NC_008023.1 862873 863373 D 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 862873..863373 Streptococcus pyogenes MGAS2096 4065939 YP_600495.1 CDS murB NC_008023.1 863523 864410 D catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 863523..864410 Streptococcus pyogenes MGAS2096 4065940 YP_600496.1 CDS potA NC_008023.1 864456 865610 D spermidine/putrescine ABC transporter ATP-binding protein 864456..865610 Streptococcus pyogenes MGAS2096 4065941 YP_600497.1 CDS potB NC_008023.1 865573 866388 D spermidine/putrescine ABC transporter permease 865573..866388 Streptococcus pyogenes MGAS2096 4065942 YP_600498.1 CDS potC NC_008023.1 866385 867161 D spermidine/putrescine ABC transporter permease 866385..867161 Streptococcus pyogenes MGAS2096 4065943 YP_600499.1 CDS MGAS2096_Spy0903 NC_008023.1 867154 868227 D spermidine/putrescine-binding protein 867154..868227 Streptococcus pyogenes MGAS2096 4065887 YP_600500.1 CDS dpiA NC_008023.1 868282 868947 R transcriptional regulatory protein dpiA complement(868282..868947) Streptococcus pyogenes MGAS2096 4065888 YP_600501.1 CDS MGAS2096_Spy0905 NC_008023.1 868928 869437 R sensor kinase dpiB complement(868928..869437) Streptococcus pyogenes MGAS2096 4065889 YP_600502.1 CDS dpiB NC_008023.1 869407 870468 R sensor kinase dpiB complement(869407..870468) Streptococcus pyogenes MGAS2096 4065890 YP_600503.1 CDS malP NC_008023.1 870629 871960 D malate-sodium symport 870629..871960 Streptococcus pyogenes MGAS2096 4065891 YP_600504.1 CDS MGAS2096_Spy0908 NC_008023.1 872089 873156 D NAD-dependent malic enzyme 872089..873156 Streptococcus pyogenes MGAS2096 4065892 YP_600505.1 CDS MGAS2096_Spy0909 NC_008023.1 873238 874329 R Zn-dependent alcohol dehydrogenases and related dehydrogenases complement(873238..874329) Streptococcus pyogenes MGAS2096 4065893 YP_600506.1 CDS aphA NC_008023.1 874523 875254 D Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 874523..875254 Streptococcus pyogenes MGAS2096 4065894 YP_600507.1 CDS MGAS2096_Spy0911 NC_008023.1 875396 876964 D chloride channel protein 875396..876964 Streptococcus pyogenes MGAS2096 4065895 YP_600508.1 CDS MGAS2096_Spy0912 NC_008023.1 877127 877741 D lipase/acylhydrolase family protein 877127..877741 Streptococcus pyogenes MGAS2096 4065896 YP_600509.1 CDS MGAS2096_Spy0913 NC_008023.1 877787 877900 D hypothetical protein 877787..877900 Streptococcus pyogenes MGAS2096 4065897 YP_600510.1 CDS MGAS2096_Spy0914 NC_008023.1 877900 879048 D hypothetical protein 877900..879048 Streptococcus pyogenes MGAS2096 4065898 YP_600511.1 CDS radC NC_008023.1 879097 879777 D Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 879097..879777 Streptococcus pyogenes MGAS2096 4065899 YP_600512.1 CDS MGAS2096_Spy0916 NC_008023.1 879779 880474 R glutamine amidotransferase complement(879779..880474) Streptococcus pyogenes MGAS2096 4065900 YP_600513.1 CDS MGAS2096_Spy0917 NC_008023.1 880484 881128 R modulates transcription in response to the NADH/NAD(+) redox state; redox-sensing transcriptional repressor Rex complement(880484..881128) Streptococcus pyogenes MGAS2096 4065901 YP_600514.1 CDS MGAS2096_Spy0918 NC_008023.1 881380 881727 R putative cytoplasmic protein complement(881380..881727) Streptococcus pyogenes MGAS2096 4065902 YP_600515.1 CDS nifS2 NC_008023.1 881717 882844 R bifunctional; cysteine desulfurase / selenocysteine lyase complement(881717..882844) Streptococcus pyogenes MGAS2096 4065903 YP_600516.1 CDS MGAS2096_Spy0920 NC_008023.1 882841 883821 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(882841..883821) Streptococcus pyogenes MGAS2096 4065904 YP_600517.1 CDS MGAS2096_Spy0921 NC_008023.1 883961 884539 R organic phosphate binding CYTH family protein complement(883961..884539) Streptococcus pyogenes MGAS2096 4065905 YP_600518.1 CDS MGAS2096_Spy0922 NC_008023.1 884627 884824 D GTP pyrophosphokinase 884627..884824 Streptococcus pyogenes MGAS2096 4065906 YP_600519.1 CDS MGAS2096_Spy0923 NC_008023.1 884860 885297 D GTP pyrophosphokinase-like protein 884860..885297 Streptococcus pyogenes MGAS2096 4065868 YP_600520.1 CDS ppnK NC_008023.1 885269 886108 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 885269..886108 Streptococcus pyogenes MGAS2096 4065869 YP_600521.1 CDS MGAS2096_Spy0925 NC_008023.1 886184 887011 D ribosomal large subunit pseudouridine synthase D 886184..887011 Streptococcus pyogenes MGAS2096 4065870 YP_600522.1 CDS eutD NC_008023.1 887015 888010 D in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 887015..888010 Streptococcus pyogenes MGAS2096 4065871 YP_600523.1 CDS MGAS2096_Spy0927 NC_008023.1 888076 888891 D short-chain dehydrogenase 888076..888891 Streptococcus pyogenes MGAS2096 4065872 YP_600524.1 CDS MGAS2096_Spy0928 NC_008023.1 889085 889774 R Na+ driven multidrug efflux pump complement(889085..889774) Streptococcus pyogenes MGAS2096 4065873 YP_600525.1 CDS proV NC_008023.1 890200 890928 D glycine betaine transport ATP-binding protein 890200..890928 Streptococcus pyogenes MGAS2096 4065874 YP_600526.1 CDS MGAS2096_Spy0930 NC_008023.1 890885 892447 D glycine betaine transport system permease / glycine betaine-binding protein 890885..892447 Streptococcus pyogenes MGAS2096 4065875 YP_600527.1 CDS guaC NC_008023.1 892704 893708 D guanosine 5'-monophosphate oxidoreductase 892704..893708 Streptococcus pyogenes MGAS2096 4065876 YP_600528.1 CDS xpt NC_008023.1 894013 894594 D Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine; xanthine phosphoribosyltransferase 894013..894594 Streptococcus pyogenes MGAS2096 4065877 YP_600529.1 CDS MGAS2096_Spy0933 NC_008023.1 894594 895877 D xanthine permease 894594..895877 Streptococcus pyogenes MGAS2096 4065878 YP_600530.1 CDS apbE NC_008023.1 895941 896879 R Iron-sulfur cluster assembly/repair protein ApbE complement(895941..896879) Streptococcus pyogenes MGAS2096 4065879 YP_600531.1 CDS MGAS2096_Spy0935 NC_008023.1 896932 897117 R 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase complement(896932..897117) Streptococcus pyogenes MGAS2096 4065880 YP_600532.1 CDS tdk2 NC_008023.1 897255 897824 D catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 897255..897824 Streptococcus pyogenes MGAS2096 4065881 YP_600533.1 CDS prfA NC_008023.1 897859 898938 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 897859..898938 Streptococcus pyogenes MGAS2096 4065882 YP_600534.1 CDS hemK NC_008023.1 898938 899777 D peptide release factor-glutamine N5-methyltransferase 898938..899777 Streptococcus pyogenes MGAS2096 4065883 YP_600535.1 CDS MGAS2096_Spy0939 NC_008023.1 899731 900351 D Sua5/YciO/YrdC/YwlC family protein 899731..900351 Streptococcus pyogenes MGAS2096 4065884 YP_600536.1 CDS MGAS2096_Spy0940 NC_008023.1 900369 900821 D phosphinothricin N-acetyltransferase 900369..900821 Streptococcus pyogenes MGAS2096 4065885 YP_600537.1 CDS glyA NC_008023.1 900805 902067 D catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 900805..902067 Streptococcus pyogenes MGAS2096 4065886 YP_600538.1 CDS MGAS2096_Spy0942 NC_008023.1 902074 903051 D hypothetical protein 902074..903051 Streptococcus pyogenes MGAS2096 4065848 YP_600539.1 CDS MGAS2096_Spy0943 NC_008023.1 903052 903651 D antigen-like protein 903052..903651 Streptococcus pyogenes MGAS2096 4065849 YP_600540.1 CDS MGAS2096_Spy0944 NC_008023.1 903661 905379 D multidrug ABC transporter permease/ATP-binding protein 903661..905379 Streptococcus pyogenes MGAS2096 4065850 YP_600541.1 CDS MGAS2096_Spy0945 NC_008023.1 905382 907109 D multidrug/protein/lipid ABC transporter family ATP-binding and permease 905382..907109 Streptococcus pyogenes MGAS2096 4065851 YP_600542.1 CDS nox NC_008023.1 907350 908720 D NADH oxidase H2O-forming 907350..908720 Streptococcus pyogenes MGAS2096 4065852 YP_600543.1 CDS ldh NC_008023.1 908879 909862 R Converts (S)-lactate and NAD(+) to pyruvate and NADH; L-lactate dehydrogenase complement(908879..909862) Streptococcus pyogenes MGAS2096 4065853 YP_600544.1 CDS gyrA NC_008023.1 910053 912539 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 910053..912539 Streptococcus pyogenes MGAS2096 4065854 YP_600545.1 CDS MGAS2096_Spy0949 NC_008023.1 912559 913308 D sortase 912559..913308 Streptococcus pyogenes MGAS2096 4065855 YP_600546.1 CDS MGAS2096_Spy0950 NC_008023.1 913388 913804 D glyoxalase family protein 913388..913804 Streptococcus pyogenes MGAS2096 4065856 YP_600547.1 CDS MGAS2096_Spy0951 NC_008023.1 914279 914410 D hypothetical protein 914279..914410 Streptococcus pyogenes MGAS2096 4065857 YP_600548.1 CDS MGAS2096_Spy0952 NC_008023.1 914361 914858 D hypothetical protein 914361..914858 Streptococcus pyogenes MGAS2096 4065858 YP_600549.1 CDS MGAS2096_Spy0953 NC_008023.1 914908 915819 R diacylglycerol kinase family protein complement(914908..915819) Streptococcus pyogenes MGAS2096 4065859 YP_600550.1 CDS MGAS2096_Spy0954 NC_008023.1 915936 916586 R hemolysin III homolog; hypothetical protein complement(915936..916586) Streptococcus pyogenes MGAS2096 4065860 YP_600551.1 CDS MGAS2096_Spy0955 NC_008023.1 916583 917023 R putative cytoplasmic protein complement(916583..917023) Streptococcus pyogenes MGAS2096 4065861 YP_600552.1 CDS rbgA NC_008023.1 917242 918090 D essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc); ribosomal biogenesis GTPase 917242..918090 Streptococcus pyogenes MGAS2096 4065862 YP_600553.1 CDS rnhB NC_008023.1 918080 918871 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 918080..918871 Streptococcus pyogenes MGAS2096 4065863 YP_600554.1 CDS smf NC_008023.1 918936 919772 D DNA processing protein 918936..919772 Streptococcus pyogenes MGAS2096 4065864 YP_600555.1 CDS MGAS2096_Spy0959 NC_008023.1 919879 922008 D catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 919879..922008 Streptococcus pyogenes MGAS2096 4065865 YP_600556.1 CDS MGAS2096_Spy0960 NC_008023.1 922083 922565 R LysR family transcriptional regulator complement(922083..922565) Streptococcus pyogenes MGAS2096 4065866 YP_600557.1 CDS MGAS2096_Spy0961 NC_008023.1 922572 922694 R LysR family transcriptional regulator complement(922572..922694) Streptococcus pyogenes MGAS2096 4065867 YP_600558.1 CDS MGAS2096_Spy0962 NC_008023.1 922980 923546 D hypothetical protein 922980..923546 Streptococcus pyogenes MGAS2096 4065829 YP_600559.1 CDS ddh NC_008023.1 923558 924553 D catalyzes the formation of pyruvate from lactate; D-lactate dehydrogenase 923558..924553 Streptococcus pyogenes MGAS2096 4065830 YP_600560.1 CDS satD NC_008023.1 924658 925323 D hypothetical protein 924658..925323 Streptococcus pyogenes MGAS2096 4065831 YP_600561.1 CDS satE NC_008023.1 925316 926032 D hypothetical protein 925316..926032 Streptococcus pyogenes MGAS2096 4065832 YP_600562.1 CDS gid NC_008023.1 926033 927541 D TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine; tRNA (uracil-5-)-methyltransferase Gid 926033..927541 Streptococcus pyogenes MGAS2096 4065833 YP_600563.1 CDS MGAS2096_Spy0967 NC_008023.1 927694 927966 D oxaloacetate decarboxylase subunit alpha 927694..927966 Streptococcus pyogenes MGAS2096 4065834 YP_600564.1 CDS oadA1 NC_008023.1 928146 929114 D oxaloacetate decarboxylase subunit alpha 928146..929114 Streptococcus pyogenes MGAS2096 4065835 YP_600565.1 CDS citC NC_008023.1 929225 930277 R (citrate (pro-3S)-lyase) ligase complement(929225..930277) Streptococcus pyogenes MGAS2096 4065836 YP_600566.1 CDS MGAS2096_Spy0970 NC_008023.1 930366 930848 R hypothetical protein complement(930366..930848) Streptococcus pyogenes MGAS2096 4065837 YP_600567.1 CDS MGAS2096_Spy0971 NC_008023.1 931327 931431 D hypothetical protein 931327..931431 Streptococcus pyogenes MGAS2096 4065838 YP_600568.1 CDS xerS NC_008023.1 931542 932648 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS; site-specific tyrosine recombinase XerS complement(931542..932648) Streptococcus pyogenes MGAS2096 4065839 YP_600569.1 CDS MGAS2096_Spy0973 NC_008023.1 933082 933555 D phage transcriptional repressor 933082..933555 Streptococcus pyogenes MGAS2096 4065840 YP_600570.1 CDS ffh NC_008023.1 933914 935482 R signal recognition particle subunit FFH/SRP54 complement(933914..935482) Streptococcus pyogenes MGAS2096 4065841 YP_600571.1 CDS ylxM NC_008023.1 935491 935832 R putative DNA-binding protein complement(935491..935832) Streptococcus pyogenes MGAS2096 4065842 YP_600572.1 CDS MGAS2096_Spy0976 NC_008023.1 935932 936645 R GntR family transcriptional regulator complement(935932..936645) Streptococcus pyogenes MGAS2096 4065843 YP_600573.1 CDS MGAS2096_Spy0977 NC_008023.1 936701 938134 R hypothetical protein complement(936701..938134) Streptococcus pyogenes MGAS2096 4065844 YP_600574.1 CDS guaA NC_008023.1 938301 939863 D contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 938301..939863 Streptococcus pyogenes MGAS2096 4065845 YP_600575.1 CDS MGAS2096_Spy0979 NC_008023.1 939905 941128 R bifunctional; UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase / UDP-N-acetylmuramoylpentapeptide-lysine N(6)-seryltransferase complement(939905..941128) Streptococcus pyogenes MGAS2096 4065846 YP_600576.1 CDS MGAS2096_Spy0980 NC_008023.1 941492 943072 R ABC transporter ATP-binding protein complement(941492..943072) Streptococcus pyogenes MGAS2096 4065847 YP_600577.1 CDS pdxK NC_008023.1 943170 943727 R hypothetical protein complement(943170..943727) Streptococcus pyogenes MGAS2096 4065809 YP_600578.1 CDS MGAS2096_Spy0982 NC_008023.1 943705 944571 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase complement(943705..944571) Streptococcus pyogenes MGAS2096 4065810 YP_600579.1 CDS MGAS2096_Spy0983 NC_008023.1 944661 945827 D GntR family transcriptional regulator 944661..945827 Streptococcus pyogenes MGAS2096 4065811 YP_600580.1 CDS rnhB NC_008023.1 946335 946691 R anaerobic ribonucleoside-triphosphate reductase complement(946335..946691) Streptococcus pyogenes MGAS2096 4065812 YP_600581.1 CDS MGAS2096_Spy0985 NC_008023.1 947013 948590 R cardiolipin synthetase complement(947013..948590) Streptococcus pyogenes MGAS2096 4065813 YP_600582.1 CDS fhs1 NC_008023.1 948675 950345 R catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase complement(948675..950345) Streptococcus pyogenes MGAS2096 4065814 YP_600583.1 CDS lplA NC_008023.1 950473 951492 R lipoate-protein ligase A complement(950473..951492) Streptococcus pyogenes MGAS2096 4065815 YP_600584.1 CDS MGAS2096_Spy0988 NC_008023.1 951539 952420 R SIR2 family protein complement(951539..952420) Streptococcus pyogenes MGAS2096 4065816 YP_600585.1 CDS MGAS2096_Spy0989 NC_008023.1 952413 953225 R hypothetical protein complement(952413..953225) Streptococcus pyogenes MGAS2096 4065817 YP_600586.1 CDS MGAS2096_Spy0990 NC_008023.1 953218 953550 R glycine cleavage system H protein complement(953218..953550) Streptococcus pyogenes MGAS2096 4065818 YP_600587.1 CDS MGAS2096_Spy0991 NC_008023.1 953592 954590 R luciferase-like monooxygenase complement(953592..954590) Streptococcus pyogenes MGAS2096 4065819 YP_600588.1 CDS MGAS2096_Spy0992 NC_008023.1 954587 955786 R NADH-dependent flavin oxidoreductase yqiG complement(954587..955786) Streptococcus pyogenes MGAS2096 4065820 YP_600589.1 CDS MGAS2096_Spy0993 NC_008023.1 955783 956634 R lipoate-protein ligase A complement(955783..956634) Streptococcus pyogenes MGAS2096 4065821 YP_600590.1 CDS dpfB NC_008023.1 956814 957506 D phosphopantothenate--cysteine ligase 956814..957506 Streptococcus pyogenes MGAS2096 4065822 YP_600591.1 CDS dfp NC_008023.1 957499 958044 D decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.; phosphopantothenoylcysteine decarboxylase 957499..958044 Streptococcus pyogenes MGAS2096 4065823 YP_600592.1 CDS MGAS2096_Spy0996 NC_008023.1 958090 958665 D integral membrane protein 958090..958665 Streptococcus pyogenes MGAS2096 4065824 YP_600593.1 CDS pgmA NC_008023.1 958959 960677 D bifunctional; phosphoglucomutase/phosphomannomutase 958959..960677 Streptococcus pyogenes MGAS2096 4065825 YP_600594.1 CDS MGAS2096_Spy0998 NC_008023.1 960890 961858 R nucleoside transport system permease complement(960890..961858) Streptococcus pyogenes MGAS2096 4065826 YP_600595.1 CDS MGAS2096_Spy0999 NC_008023.1 961848 962939 R nucleoside transport system permease complement(961848..962939) Streptococcus pyogenes MGAS2096 4065827 YP_600596.1 CDS MGAS2096_Spy1000 NC_008023.1 962905 964455 R nucleoside transport ATP-binding protein complement(962905..964455) Streptococcus pyogenes MGAS2096 4065828 YP_600597.1 CDS MGAS2096_Spy1001 NC_008023.1 964576 965628 R nucleoside-binding protein complement(964576..965628) Streptococcus pyogenes MGAS2096 4065020 YP_600598.1 CDS cdd NC_008023.1 965722 966111 R Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase complement(965722..966111) Streptococcus pyogenes MGAS2096 4065021 YP_600599.1 CDS MGAS2096_Spy1003 NC_008023.1 966762 967388 R 16S rRNA m(2)G 1207 methyltransferase complement(966762..967388) Streptococcus pyogenes MGAS2096 4065022 YP_600600.1 CDS coaA NC_008023.1 967623 968543 D catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 967623..968543 Streptococcus pyogenes MGAS2096 4065023 YP_600601.2 CDS rpsT NC_008023.1 968612 968845 D binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 968612..968845 Streptococcus pyogenes MGAS2096 4065024 YP_600602.1 CDS ciaH NC_008023.1 968970 970280 R sensor protein ciaH complement(968970..970280) Streptococcus pyogenes MGAS2096 4065025 YP_600603.1 CDS ciaR NC_008023.1 970273 970947 R transcriptional regulatory protein ciaR complement(970273..970947) Streptococcus pyogenes MGAS2096 4065026 YP_600604.1 CDS pepN NC_008023.1 971293 973890 R bifunctional; lysyl aminopeptidase / alanine aminopeptidase complement(971293..973890) Streptococcus pyogenes MGAS2096 4065027 YP_600605.1 CDS MGAS2096_Spy1009 NC_008023.1 973887 974081 R hypothetical protein complement(973887..974081) Streptococcus pyogenes MGAS2096 4065028 YP_600606.1 CDS phoU NC_008023.1 974035 974688 R phosphate transporter PhoU complement(974035..974688) Streptococcus pyogenes MGAS2096 4065029 YP_600607.1 CDS pstB NC_008023.1 974756 975517 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(974756..975517) Streptococcus pyogenes MGAS2096 4065030 YP_600608.1 CDS pstB2 NC_008023.1 975527 976330 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(975527..976330) Streptococcus pyogenes MGAS2096 4065031 YP_600609.1 CDS pstA NC_008023.1 976346 977233 R phosphate ABC transporter permease complement(976346..977233) Streptococcus pyogenes MGAS2096 4065032 YP_600610.1 CDS pstC NC_008023.1 977223 978158 R phosphate ABC transporter permease complement(977223..978158) Streptococcus pyogenes MGAS2096 4065033 YP_600611.1 CDS pstS NC_008023.1 978169 979035 R phosphate-binding protein complement(978169..979035) Streptococcus pyogenes MGAS2096 4065034 YP_600612.1 CDS MGAS2096_Spy1016 NC_008023.1 979174 980484 R putative 23S rRNA m(5)C methyltransferase complement(979174..980484) Streptococcus pyogenes MGAS2096 4065035 YP_600613.1 CDS MGAS2096_Spy1017 NC_008023.1 980487 981296 R myo-inositol-1(or 4)-monophosphatase complement(980487..981296) Streptococcus pyogenes MGAS2096 4065036 YP_600614.1 CDS MGAS2096_Spy1018 NC_008023.1 981265 981555 R hypothetical protein complement(981265..981555) Streptococcus pyogenes MGAS2096 4065037 YP_600615.1 CDS spxA NC_008023.1 981545 981949 R the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx complement(981545..981949) Streptococcus pyogenes MGAS2096 4065038 YP_600616.1 CDS mreA NC_008023.1 981992 982924 R catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase complement(981992..982924) Streptococcus pyogenes MGAS2096 4064805 YP_600617.1 CDS truB NC_008023.1 982953 983837 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(982953..983837) Streptococcus pyogenes MGAS2096 4064806 YP_600618.1 CDS MGAS2096_Spy1022 NC_008023.1 983953 985293 R hypothetical protein complement(983953..985293) Streptococcus pyogenes MGAS2096 4064807 YP_600619.1 CDS MGAS2096_Spy1023 NC_008023.1 985390 986346 R integral membrane protein complement(985390..986346) Streptococcus pyogenes MGAS2096 4064808 YP_600620.1 CDS MGAS2096_Spy1024 NC_008023.1 986357 986953 R type I restriction-modification system specificity subunit complement(986357..986953) Streptococcus pyogenes MGAS2096 4064809 YP_600621.1 CDS MGAS2096_Spy1025 NC_008023.1 987045 989681 R ABC transporter permease complement(987045..989681) Streptococcus pyogenes MGAS2096 4064810 YP_600622.1 CDS MGAS2096_Spy1026 NC_008023.1 989696 990409 R ABC transporter ATP-binding protein complement(989696..990409) Streptococcus pyogenes MGAS2096 4064811 YP_600623.1 CDS MGAS2096_Spy1027 NC_008023.1 990515 991057 D TetR family transcriptional regulator 990515..991057 Streptococcus pyogenes MGAS2096 4064812 YP_600624.1 CDS MGAS2096_Spy1028 NC_008023.1 991054 991197 R hypothetical protein complement(991054..991197) Streptococcus pyogenes MGAS2096 4064813 YP_600625.1 CDS MGAS2096_Spy1029 NC_008023.1 991200 991841 R NAD-dependent K+ or Na(+) uptake system component /GntR family transcriptional regulator complement(991200..991841) Streptococcus pyogenes MGAS2096 4064814 YP_600626.1 CDS MGAS2096_Spy1030 NC_008023.1 992004 992495 R Gls24 family general stress protein complement(992004..992495) Streptococcus pyogenes MGAS2096 4064815 YP_600627.1 CDS MGAS2096_Spy1031 NC_008023.1 992503 992703 R hypothetical protein complement(992503..992703) Streptococcus pyogenes MGAS2096 4064816 YP_600628.1 CDS MGAS2096_Spy1032 NC_008023.1 992744 993283 R Gls24 family general stress protein complement(992744..993283) Streptococcus pyogenes MGAS2096 4064817 YP_600629.1 CDS MGAS2096_Spy1033 NC_008023.1 993296 993484 R small integral membrane protein complement(993296..993484) Streptococcus pyogenes MGAS2096 4064818 YP_600630.1 CDS MGAS2096_Spy1034 NC_008023.1 993495 994106 R hypothetical protein complement(993495..994106) Streptococcus pyogenes MGAS2096 4064819 YP_600631.1 CDS MGAS2096_Spy1035 NC_008023.1 994143 994391 R integral membrane protein complement(994143..994391) Streptococcus pyogenes MGAS2096 4064820 YP_600632.1 CDS pcrA NC_008023.1 994755 997073 R DNA helicase II complement(994755..997073) Streptococcus pyogenes MGAS2096 4064821 YP_600633.1 CDS MGAS2096_Spy1038 NC_008023.1 997439 997609 R hypothetical protein complement(997439..997609) Streptococcus pyogenes MGAS2096 4064822 YP_600634.1 CDS MGAS2096_Spy1037 NC_008023.1 997600 998922 D Na(+)-linked D-alanine glycine permease 997600..998922 Streptococcus pyogenes MGAS2096 4064823 YP_600635.1 CDS MGAS2096_Spy1039 NC_008023.1 999042 999329 D cobalt-zinc-cadmium resistance protein czcD 999042..999329 Streptococcus pyogenes MGAS2096 4064824 YP_600636.1 CDS MGAS2096_Spy1040 NC_008023.1 999317 1000276 D cobalt-zinc-cadmium resistance protein czcD 999317..1000276 Streptococcus pyogenes MGAS2096 4065264 YP_600637.1 CDS cfa NC_008023.1 1000646 1001419 R cAMP factor complement(1000646..1001419) Streptococcus pyogenes MGAS2096 4065265 YP_600638.1 CDS MGAS2096_Spy1042 NC_008023.1 1001789 1002625 R histidine-binding protein complement(1001789..1002625) Streptococcus pyogenes MGAS2096 4065266 YP_600639.1 CDS MGAS2096_Spy1043 NC_008023.1 1002641 1003270 R histidine transport ATP-binding protein hisP complement(1002641..1003270) Streptococcus pyogenes MGAS2096 4065267 YP_600640.1 CDS MGAS2096_Spy1044 NC_008023.1 1003280 1003921 R histidine transport system permease hisM complement(1003280..1003921) Streptococcus pyogenes MGAS2096 4065268 YP_600641.1 CDS MGAS2096_Spy1045 NC_008023.1 1004027 1004362 R PhnA protein complement(1004027..1004362) Streptococcus pyogenes MGAS2096 4065269 YP_600642.1 CDS glmS NC_008023.1 1004544 1006358 R Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase complement(1004544..1006358) Streptococcus pyogenes MGAS2096 4065270 YP_600643.1 CDS sipC NC_008023.1 1006534 1007091 R Signal peptidase I complement(1006534..1007091) Streptococcus pyogenes MGAS2096 4065271 YP_600644.1 CDS pyk NC_008023.1 1007309 1008811 R catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase complement(1007309..1008811) Streptococcus pyogenes MGAS2096 4065272 YP_600645.1 CDS pfk NC_008023.1 1008874 1009887 R catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase complement(1008874..1009887) Streptococcus pyogenes MGAS2096 4065273 YP_600646.1 CDS dnaE NC_008023.1 1009967 1013077 R Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria.; DNA polymerase III DnaE complement(1009967..1013077) Streptococcus pyogenes MGAS2096 4065274 YP_600647.1 CDS MGAS2096_Spy1051 NC_008023.1 1013172 1013633 D GntR family transcriptional regulator 1013172..1013633 Streptococcus pyogenes MGAS2096 4065275 YP_600648.1 CDS MGAS2096_Spy1052 NC_008023.1 1013633 1014331 D ABC transporter ATP-binding protein 1013633..1014331 Streptococcus pyogenes MGAS2096 4065276 YP_600649.1 CDS MGAS2096_Spy1053 NC_008023.1 1014341 1015126 D ABC transporter permease 1014341..1015126 Streptococcus pyogenes MGAS2096 4065277 YP_600650.1 CDS MGAS2096_Spy1054 NC_008023.1 1015259 1015873 R putative membrane-associated alkaline phosphatase complement(1015259..1015873) Streptococcus pyogenes MGAS2096 4065278 YP_600651.1 CDS MGAS2096_Spy1055 NC_008023.1 1016383 1016496 D phage protein 1016383..1016496 Streptococcus pyogenes MGAS2096 4065279 YP_600652.1 CDS MGAS2096_Spy1056 NC_008023.1 1016614 1017234 D phage protein 1016614..1017234 Streptococcus pyogenes MGAS2096 4065280 YP_600653.1 CDS glgP NC_008023.1 1017491 1019755 R maltodextrin phosphorylase complement(1017491..1019755) Streptococcus pyogenes MGAS2096 4065281 YP_600654.1 CDS malM NC_008023.1 1019790 1020530 R 4-alpha-glucanotransferase complement(1019790..1020530) Streptococcus pyogenes MGAS2096 4065282 YP_600655.1 CDS MGAS2096_Spy1059 NC_008023.1 1020472 1021059 R 4-alpha-glucanotransferase complement(1020472..1021059) Streptococcus pyogenes MGAS2096 4064674 YP_600656.1 CDS malR NC_008023.1 1021395 1022489 R LacI family transcriptional regulator complement(1021395..1022489) Streptococcus pyogenes MGAS2096 4064675 YP_600657.1 CDS malX NC_008023.1 1022658 1023905 D maltose/maltodextrin-binding protein 1022658..1023905 Streptococcus pyogenes MGAS2096 4064676 YP_600658.1 CDS malC NC_008023.1 1024178 1025539 D maltodextrin transport system permease malC 1024178..1025539 Streptococcus pyogenes MGAS2096 4064677 YP_600659.1 CDS malD NC_008023.1 1025539 1026375 D maltose transport system permease malG 1025539..1026375 Streptococcus pyogenes MGAS2096 4064678 YP_600660.1 CDS MGAS2096_Spy1064 NC_008023.1 1026377 1026538 R hypothetical protein complement(1026377..1026538) Streptococcus pyogenes MGAS2096 4064679 YP_600661.1 CDS MGAS2096_Spy1065 NC_008023.1 1026556 1026825 D transposase 1026556..1026825 Streptococcus pyogenes MGAS2096 4064680 YP_600662.1 CDS MGAS2096_Spy1066 NC_008023.1 1026749 1027336 D transposase 1026749..1027336 Streptococcus pyogenes MGAS2096 4064681 YP_600663.1 CDS MGAS2096_Spy1067 NC_008023.1 1027561 1027785 D transposase 1027561..1027785 Streptococcus pyogenes MGAS2096 4064682 YP_600664.1 CDS MGAS2096_Spy1068 NC_008023.1 1027850 1028833 R esterase complement(1027850..1028833) Streptococcus pyogenes MGAS2096 4064683 YP_600665.1 CDS dltD NC_008023.1 1028864 1030114 R protein dltD precursor complement(1028864..1030114) Streptococcus pyogenes MGAS2096 4064684 YP_600666.1 CDS MGAS2096_Spy1070 NC_008023.1 1030107 1030346 R D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 2 complement(1030107..1030346) Streptococcus pyogenes MGAS2096 4064685 YP_600667.1 CDS MGAS2096_Spy1071 NC_008023.1 1030364 1031620 R protein dltB complement(1030364..1031620) Streptococcus pyogenes MGAS2096 4064686 YP_600668.1 CDS MGAS2096_Spy1072 NC_008023.1 1031617 1032216 R D-alanine-activating enzyme complement(1031617..1032216) Streptococcus pyogenes MGAS2096 4064687 YP_600669.1 CDS dltA NC_008023.1 1032302 1033156 R D-alanine-activating enzyme complement(1032302..1033156) Streptococcus pyogenes MGAS2096 4064688 YP_600670.1 CDS MGAS2096_Spy1074 NC_008023.1 1033168 1033311 R hypothetical protein complement(1033168..1033311) Streptococcus pyogenes MGAS2096 4064689 YP_600671.1 CDS uvrB NC_008023.1 1033575 1035566 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B complement(1033575..1035566) Streptococcus pyogenes MGAS2096 4064690 YP_600672.1 CDS glnH NC_008023.1 1035759 1037933 D glutamine-binding protein / glutamine transport system permease glnP 1035759..1037933 Streptococcus pyogenes MGAS2096 4064691 YP_600673.1 CDS glnQ2 NC_008023.1 1037933 1038673 D glutamine transport ATP-binding protein glnQ 1037933..1038673 Streptococcus pyogenes MGAS2096 4064692 YP_600674.1 CDS MGAS2096_Spy1078 NC_008023.1 1038831 1040318 D transposase 1038831..1040318 Streptococcus pyogenes MGAS2096 4064693 YP_600675.1 CDS MGAS2096_Spy1079 NC_008023.1 1040367 1040519 R hypothetical protein complement(1040367..1040519) Streptococcus pyogenes MGAS2096 4066346 YP_600676.1 CDS MGAS2096_Spy1080 NC_008023.1 1040516 1041895 R PTS system cellobiose-specific transporter subunit IIC complement(1040516..1041895) Streptococcus pyogenes MGAS2096 4066347 YP_600677.1 CDS MGAS2096_Spy1081 NC_008023.1 1042073 1042522 R hypothetical protein complement(1042073..1042522) Streptococcus pyogenes MGAS2096 4066348 YP_600678.1 CDS MGAS2096_Spy1082 NC_008023.1 1042519 1042854 R PTS system cellobiose-specific transporter subunit IIA complement(1042519..1042854) Streptococcus pyogenes MGAS2096 4066349 YP_600679.1 CDS MGAS2096_Spy1083 NC_008023.1 1042857 1043198 R PTS system cellobiose-specific transporter subunit IIB complement(1042857..1043198) Streptococcus pyogenes MGAS2096 4066350 YP_600680.1 CDS MGAS2096_Spy1084 NC_008023.1 1043191 1045185 R BigG family transcription antiterminator / PTS system, mannitol (Cryptic)-specific IIA component complement(1043191..1045185) Streptococcus pyogenes MGAS2096 4066351 YP_600681.1 CDS MGAS2096_Spy1085 NC_008023.1 1045291 1046349 R outer surface protein complement(1045291..1046349) Streptococcus pyogenes MGAS2096 4066352 YP_600682.1 CDS bglA2 NC_008023.1 1046395 1047819 R Beta-glucosidase complement(1046395..1047819) Streptococcus pyogenes MGAS2096 4066353 YP_600683.1 CDS MGAS2096_Spy1087 NC_008023.1 1048008 1048715 D nicotinamide mononucleotide transporter 1048008..1048715 Streptococcus pyogenes MGAS2096 4066354 YP_600684.1 CDS MGAS2096_Spy1088 NC_008023.1 1048720 1048878 R putative cytoplasmic protein complement(1048720..1048878) Streptococcus pyogenes MGAS2096 4066355 YP_600685.2 CDS obgE NC_008023.1 1048947 1050254 R essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE complement(1048947..1050254) Streptococcus pyogenes MGAS2096 4066356 YP_600686.1 CDS MGAS2096_Spy1090 NC_008023.1 1050317 1050445 R hypothetical protein complement(1050317..1050445) Streptococcus pyogenes MGAS2096 4066357 YP_600687.1 CDS MGAS2096_Spy1091 NC_008023.1 1050669 1051202 D transposase 1050669..1051202 Streptococcus pyogenes MGAS2096 4066358 YP_600688.1 CDS MGAS2096_Spy1092 NC_008023.1 1051223 1051786 D transposase 1051223..1051786 Streptococcus pyogenes MGAS2096 4066359 YP_600689.1 CDS MGAS2096_Spy1093 NC_008023.1 1051801 1052028 D transposase 1051801..1052028 Streptococcus pyogenes MGAS2096 4066360 YP_600690.1 CDS rsuA NC_008023.1 1052077 1052811 R ribosomal small subunit pseudouridine synthase A complement(1052077..1052811) Streptococcus pyogenes MGAS2096 4066361 YP_600691.1 CDS MGAS2096_Spy1095 NC_008023.1 1052922 1053287 D hypothetical protein 1052922..1053287 Streptococcus pyogenes MGAS2096 4066362 YP_600692.1 CDS MGAS2096_Spy1096 NC_008023.1 1053407 1054096 R major facilitator transporter complement(1053407..1054096) Streptococcus pyogenes MGAS2096 4066363 YP_600693.1 CDS MGAS2096_Spy1097 NC_008023.1 1054144 1054494 R major facilitator transporter complement(1054144..1054494) Streptococcus pyogenes MGAS2096 4066364 YP_600694.1 CDS MGAS2096_Spy1098 NC_008023.1 1054412 1054627 R major facilitator transporter complement(1054412..1054627) Streptococcus pyogenes MGAS2096 4065225 YP_600695.1 CDS MGAS2096_Spy1099 NC_008023.1 1054929 1056485 D hypothetical protein 1054929..1056485 Streptococcus pyogenes MGAS2096 4065226 YP_600696.1 CDS MGAS2096_Spy1100 NC_008023.1 1056590 1056991 R thioesterase superfamily protein complement(1056590..1056991) Streptococcus pyogenes MGAS2096 4065227 YP_600697.1 CDS MGAS2096_Spy1101 NC_008023.1 1057076 1057315 R phosphorylase Pnp/Udp family protein complement(1057076..1057315) Streptococcus pyogenes MGAS2096 4065228 YP_600698.1 CDS MGAS2096_Spy1102 NC_008023.1 1057387 1057587 R phosphorylase Pnp/Udp family protein complement(1057387..1057587) Streptococcus pyogenes MGAS2096 4065229 YP_600699.1 CDS MGAS2096_Spy1103 NC_008023.1 1057904 1059685 R site-specific recombinase complement(1057904..1059685) Streptococcus pyogenes MGAS2096 4065230 YP_600700.1 CDS MGAS2096_Spy1104 NC_008023.1 1059868 1060245 R MazF protein complement(1059868..1060245) Streptococcus pyogenes MGAS2096 4065231 YP_600701.1 CDS MGAS2096_Spy1105 NC_008023.1 1060848 1061333 R RNA polymerase ECF-type sigma factor complement(1060848..1061333) Streptococcus pyogenes MGAS2096 4065232 YP_600702.1 CDS MGAS2096_Spy1106 NC_008023.1 1061809 1061979 R hypothetical protein complement(1061809..1061979) Streptococcus pyogenes MGAS2096 4065233 YP_600703.1 CDS MGAS2096_Spy1107 NC_008023.1 1062074 1063105 R two-component system histidine kinase complement(1062074..1063105) Streptococcus pyogenes MGAS2096 4065234 YP_600704.1 CDS MGAS2096_Spy1108 NC_008023.1 1063102 1063344 R two-component response regulator complement(1063102..1063344) Streptococcus pyogenes MGAS2096 4065235 YP_600705.1 CDS MGAS2096_Spy1109 NC_008023.1 1063344 1063823 R two-component response regulator complement(1063344..1063823) Streptococcus pyogenes MGAS2096 4065236 YP_600706.1 CDS MGAS2096_Spy1110 NC_008023.1 1063849 1066446 R ABC transporter permease complement(1063849..1066446) Streptococcus pyogenes MGAS2096 4065237 YP_600707.1 CDS MGAS2096_Spy1111 NC_008023.1 1066400 1067086 R ABC transporter ATP-binding protein complement(1066400..1067086) Streptococcus pyogenes MGAS2096 4065238 YP_600708.1 CDS MGAS2096_Spy1112 NC_008023.1 1067207 1067737 R transcriptional regulator complement(1067207..1067737) Streptococcus pyogenes MGAS2096 4065239 YP_600709.1 CDS MGAS2096_Spy1113 NC_008023.1 1067839 1069257 D Na+ driven multidrug efflux pump 1067839..1069257 Streptococcus pyogenes MGAS2096 4065240 YP_600710.1 CDS MGAS2096_Spy1114 NC_008023.1 1069312 1069497 R hypothetical protein complement(1069312..1069497) Streptococcus pyogenes MGAS2096 4065241 YP_600711.1 CDS MGAS2096_Spy1115 NC_008023.1 1069501 1070259 R ferredoxin complement(1069501..1070259) Streptococcus pyogenes MGAS2096 4065242 YP_600712.1 CDS MGAS2096_Spy1116 NC_008023.1 1070268 1070864 R TetR family transcriptional regulator complement(1070268..1070864) Streptococcus pyogenes MGAS2096 4065243 YP_600713.1 CDS MGAS2096_Spy1117 NC_008023.1 1070986 1071693 R hypothetical protein complement(1070986..1071693) Streptococcus pyogenes MGAS2096 4065244 YP_600714.1 CDS MGAS2096_Spy1118 NC_008023.1 1071696 1072328 R virginiamycin A acetyltransferase complement(1071696..1072328) Streptococcus pyogenes MGAS2096 4065001 YP_600715.1 CDS MGAS2096_Spy1119 NC_008023.1 1072455 1072748 R hypothetical protein complement(1072455..1072748) Streptococcus pyogenes MGAS2096 4065002 YP_600716.1 CDS MGAS2096_Spy1120 NC_008023.1 1073071 1073430 D MerR family transcriptional regulator 1073071..1073430 Streptococcus pyogenes MGAS2096 4065003 YP_600717.1 CDS MGAS2096_Spy1121 NC_008023.1 1073455 1075233 R antigen-like protein complement(1073455..1075233) Streptococcus pyogenes MGAS2096 4065004 YP_600718.1 CDS MGAS2096_Spy1122 NC_008023.1 1075269 1076054 R sortase complement(1075269..1076054) Streptococcus pyogenes MGAS2096 4065005 YP_600719.1 CDS MGAS2096_Spy1123 NC_008023.1 1076122 1076526 R hypothetical protein complement(1076122..1076526) Streptococcus pyogenes MGAS2096 4065006 YP_600720.1 CDS MGAS2096_Spy1124 NC_008023.1 1076507 1077358 R adenine-specific methyltransferase complement(1076507..1077358) Streptococcus pyogenes MGAS2096 4065007 YP_600721.1 CDS MGAS2096_Spy1125 NC_008023.1 1077345 1079774 R TRSE protein complement(1077345..1079774) Streptococcus pyogenes MGAS2096 4065008 YP_600722.1 CDS MGAS2096_Spy1126 NC_008023.1 1080101 1080364 R hypothetical protein complement(1080101..1080364) Streptococcus pyogenes MGAS2096 4065009 YP_600723.1 CDS MGAS2096_Spy1127 NC_008023.1 1080367 1081218 R hypothetical protein complement(1080367..1081218) Streptococcus pyogenes MGAS2096 4065010 YP_600724.1 CDS MGAS2096_Spy1128 NC_008023.1 1081209 1081835 R adenine-specific methyltransferase complement(1081209..1081835) Streptococcus pyogenes MGAS2096 4065011 YP_600725.1 CDS MGAS2096_Spy1129 NC_008023.1 1081864 1082235 R aspartyl/glutamyl-tRNA amidotransferase subunit A complement(1081864..1082235) Streptococcus pyogenes MGAS2096 4065012 YP_600726.1 CDS MGAS2096_Spy1130 NC_008023.1 1082250 1084043 R TraG/TraD family protein complement(1082250..1084043) Streptococcus pyogenes MGAS2096 4065013 YP_600727.1 CDS MGAS2096_Spy1131 NC_008023.1 1084243 1085103 R hypothetical protein complement(1084243..1085103) Streptococcus pyogenes MGAS2096 4065014 YP_600728.1 CDS MGAS2096_Spy1132 NC_008023.1 1085103 1085921 R hypothetical protein complement(1085103..1085921) Streptococcus pyogenes MGAS2096 4065015 YP_600729.1 CDS MGAS2096_Spy1133 NC_008023.1 1085863 1087338 R relaxase complement(1085863..1087338) Streptococcus pyogenes MGAS2096 4065016 YP_600730.1 CDS MGAS2096_Spy1134 NC_008023.1 1087275 1087607 R relaxosome component complement(1087275..1087607) Streptococcus pyogenes MGAS2096 4065017 YP_600731.1 CDS MGAS2096_Spy1135 NC_008023.1 1088210 1089199 R LtrC complement(1088210..1089199) Streptococcus pyogenes MGAS2096 4065018 YP_600732.1 CDS MGAS2096_Spy1136 NC_008023.1 1089279 1090217 R hypothetical protein complement(1089279..1090217) Streptococcus pyogenes MGAS2096 4065019 YP_600733.1 CDS MGAS2096_Spy1137 NC_008023.1 1090355 1091569 R hypothetical protein complement(1090355..1091569) Streptococcus pyogenes MGAS2096 4066326 YP_600734.1 CDS MGAS2096_Spy1138 NC_008023.1 1091687 1092016 R hypothetical protein complement(1091687..1092016) Streptococcus pyogenes MGAS2096 4066327 YP_600735.1 CDS MGAS2096_Spy1139 NC_008023.1 1092092 1093030 R SNF2 family; superfamily II DNA/RNA helicase complement(1092092..1093030) Streptococcus pyogenes MGAS2096 4066328 YP_600736.1 CDS MGAS2096_Spy1140 NC_008023.1 1092958 1094889 R site-specific recombinase complement(1092958..1094889) Streptococcus pyogenes MGAS2096 4066329 YP_600737.1 CDS MGAS2096_Spy1141 NC_008023.1 1095206 1095436 R putative cytoplasmic protein complement(1095206..1095436) Streptococcus pyogenes MGAS2096 4066330 YP_600738.1 CDS MGAS2096_Spy1142 NC_008023.1 1095513 1096367 R chromosome partitioning protein parB complement(1095513..1096367) Streptococcus pyogenes MGAS2096 4066331 YP_600739.1 CDS MGAS2096_Spy1143 NC_008023.1 1096375 1097340 R plasmid recombination protein Mob family complement(1096375..1097340) Streptococcus pyogenes MGAS2096 4066332 YP_600740.1 CDS MGAS2096_Spy1144 NC_008023.1 1097818 1098813 R hypothetical protein complement(1097818..1098813) Streptococcus pyogenes MGAS2096 4066333 YP_600741.1 CDS MGAS2096_Spy1145 NC_008023.1 1098968 1099489 R RNA polymerase ECF-type sigma factor complement(1098968..1099489) Streptococcus pyogenes MGAS2096 4066334 YP_600742.1 CDS MGAS2096_Spy1146 NC_008023.1 1099518 1099949 R putative cytoplasmic protein complement(1099518..1099949) Streptococcus pyogenes MGAS2096 4066335 YP_600743.1 CDS MGAS2096_Spy1147 NC_008023.1 1100044 1100619 R RNA polymerase sigma-B factor complement(1100044..1100619) Streptococcus pyogenes MGAS2096 4066336 YP_600744.1 CDS MGAS2096_Spy1148 NC_008023.1 1101044 1101217 R hypothetical protein complement(1101044..1101217) Streptococcus pyogenes MGAS2096 4066337 YP_600745.1 CDS MGAS2096_Spy1149 NC_008023.1 1101269 1103188 R tetracycline resistance protein tetM complement(1101269..1103188) Streptococcus pyogenes MGAS2096 4066338 YP_600746.1 CDS MGAS2096_Spy1150 NC_008023.1 1103555 1103929 R TnpV complement(1103555..1103929) Streptococcus pyogenes MGAS2096 4066339 YP_600747.1 CDS MGAS2096_Spy1151 NC_008023.1 1103910 1111160 R SNF2 family; superfamily II DNA/RNA helicase complement(1103910..1111160) Streptococcus pyogenes MGAS2096 4066340 YP_600748.1 CDS MGAS2096_Spy1152 NC_008023.1 1111195 1111419 R hypothetical protein complement(1111195..1111419) Streptococcus pyogenes MGAS2096 4066341 YP_600749.1 CDS MGAS2096_Spy1154 NC_008023.1 1111635 1112330 R hypothetical protein complement(1111635..1112330) Streptococcus pyogenes MGAS2096 4066342 YP_600750.1 CDS MGAS2096_Spy1153 NC_008023.1 1112290 1113006 D hypothetical protein 1112290..1113006 Streptococcus pyogenes MGAS2096 4066343 YP_600751.1 CDS MGAS2096_Spy1155 NC_008023.1 1113060 1113332 R hypothetical protein complement(1113060..1113332) Streptococcus pyogenes MGAS2096 4066344 YP_600752.1 CDS MGAS2096_Spy1156 NC_008023.1 1113797 1117945 R collagen adhesion protein complement(1113797..1117945) Streptococcus pyogenes MGAS2096 4066345 YP_600753.1 CDS MGAS2096_Spy1157 NC_008023.1 1118131 1119096 R chromosome partitioning protein parB complement(1118131..1119096) Streptococcus pyogenes MGAS2096 4065117 YP_600754.1 CDS MGAS2096_Spy1158 NC_008023.1 1119020 1119847 R chromosome partitioning protein parA complement(1119020..1119847) Streptococcus pyogenes MGAS2096 4065118 YP_600755.1 CDS MGAS2096_Spy1159 NC_008023.1 1119967 1120305 R hypothetical protein complement(1119967..1120305) Streptococcus pyogenes MGAS2096 4065119 YP_600756.1 CDS MGAS2096_Spy1160 NC_008023.1 1120818 1122212 R 23S rRNA m(5)U1939 methyltransferase complement(1120818..1122212) Streptococcus pyogenes MGAS2096 4065120 YP_600757.1 CDS MGAS2096_Spy1161 NC_008023.1 1122363 1123712 R LytR family transcriptional regulator complement(1122363..1123712) Streptococcus pyogenes MGAS2096 4065121 YP_600758.1 CDS aroK NC_008023.1 1123920 1124411 R catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase complement(1123920..1124411) Streptococcus pyogenes MGAS2096 4065122 YP_600759.1 CDS MGAS2096_Spy1163 NC_008023.1 1124404 1125696 R catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase complement(1124404..1125696) Streptococcus pyogenes MGAS2096 4065123 YP_600760.1 CDS MGAS2096_Spy1164 NC_008023.1 1125798 1126763 R ribonuclease BN complement(1125798..1126763) Streptococcus pyogenes MGAS2096 4065124 YP_600761.1 CDS map NC_008023.1 1126765 1127625 R catalyzes the removal of N-terminal amino acids from peptides and arylamides; methionine aminopeptidase complement(1126765..1127625) Streptococcus pyogenes MGAS2096 4065125 YP_600762.1 CDS MGAS2096_Spy1166 NC_008023.1 1127641 1128936 R hypothetical protein complement(1127641..1128936) Streptococcus pyogenes MGAS2096 4065126 YP_600763.1 CDS MGAS2096_Spy1167 NC_008023.1 1128933 1129475 R ribosomal-protein-S5-alanine acetyltransferase complement(1128933..1129475) Streptococcus pyogenes MGAS2096 4065127 YP_600764.1 CDS grab NC_008023.1 1129713 1130282 R protein G-related alpha 2M-binding protein complement(1129713..1130282) Streptococcus pyogenes MGAS2096 4065128 YP_600765.1 CDS murZ NC_008023.1 1130640 1131899 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(1130640..1131899) Streptococcus pyogenes MGAS2096 4065129 YP_600766.1 CDS metK2 NC_008023.1 1132073 1133269 R catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase complement(1132073..1133269) Streptococcus pyogenes MGAS2096 4065130 YP_600767.1 CDS inlA NC_008023.1 1133805 1136183 R internalin protein complement(1133805..1136183) Streptococcus pyogenes MGAS2096 4065131 YP_600768.1 CDS birA NC_008023.1 1136387 1137205 D catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 1136387..1137205 Streptococcus pyogenes MGAS2096 4065132 YP_600769.1 CDS MGAS2096_Spy1173 NC_008023.1 1137304 1137564 R hypothetical protein complement(1137304..1137564) Streptococcus pyogenes MGAS2096 4065133 YP_600770.1 CDS MGAS2096_Spy1174 NC_008023.1 1137649 1138791 R transposase complement(1137649..1138791) Streptococcus pyogenes MGAS2096 4065134 YP_600771.1 CDS MGAS2096_Spy1175 NC_008023.1 1139052 1140314 R DNA polymerase III subunit gamma/tau complement(1139052..1140314) Streptococcus pyogenes MGAS2096 4065135 YP_600772.1 CDS MGAS2096_Spy1176 NC_008023.1 1140736 1141233 R GAF domain-containing protein complement(1140736..1141233) Streptococcus pyogenes MGAS2096 4065439 YP_600773.1 CDS MGAS2096_Spy1177 NC_008023.1 1141378 1142187 D hypothetical protein 1141378..1142187 Streptococcus pyogenes MGAS2096 4065440 YP_600774.1 CDS MGAS2096_Spy1178 NC_008023.1 1142240 1142503 R hypothetical protein complement(1142240..1142503) Streptococcus pyogenes MGAS2096 4065441 YP_600775.1 CDS MGAS2096_Spy1179 NC_008023.1 1142583 1142771 R uridine kinase complement(1142583..1142771) Streptococcus pyogenes MGAS2096 4065442 YP_600776.1 CDS udk NC_008023.1 1142806 1143222 R uridine kinase complement(1142806..1143222) Streptococcus pyogenes MGAS2096 4065443 YP_600777.1 CDS deaD2 NC_008023.1 1143275 1144393 D ATP-dependent RNA helicase 1143275..1144393 Streptococcus pyogenes MGAS2096 4065444 YP_600778.1 CDS MGAS2096_Spy1182 NC_008023.1 1144504 1144992 R polysaccharide deacetylase family protein complement(1144504..1144992) Streptococcus pyogenes MGAS2096 4065445 YP_600779.1 CDS MGAS2096_Spy1183 NC_008023.1 1145043 1145777 R polysaccharide deacetylase family protein complement(1145043..1145777) Streptococcus pyogenes MGAS2096 4065446 YP_600780.1 CDS gapN NC_008023.1 1145873 1147300 R NADP-dependent glyceraldehyde-3-phosphate dehydrogenase complement(1145873..1147300) Streptococcus pyogenes MGAS2096 4065447 YP_600781.1 CDS pstI NC_008023.1 1147485 1149218 R phosphoenolpyruvate-protein phosphotransferase complement(1147485..1149218) Streptococcus pyogenes MGAS2096 4065448 YP_600782.1 CDS ptsH NC_008023.1 1149223 1149486 R phosphocarrier protein HPr complement(1149223..1149486) Streptococcus pyogenes MGAS2096 4065449 YP_600783.1 CDS nrdH NC_008023.1 1149846 1150097 D glutaredoxin 1149846..1150097 Streptococcus pyogenes MGAS2096 4065450 YP_600784.1 CDS nrdE2 NC_008023.1 1150117 1152276 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1150117..1152276 Streptococcus pyogenes MGAS2096 4065451 YP_600785.1 CDS nrdF NC_008023.1 1152598 1153557 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 1152598..1153557 Streptococcus pyogenes MGAS2096 4065452 YP_600786.1 CDS MGAS2096_Spy1190 NC_008023.1 1153532 1154845 D chloride channel protein 1153532..1154845 Streptococcus pyogenes MGAS2096 4065453 YP_600787.1 CDS MGAS2096_Spy1191 NC_008023.1 1154941 1155234 D transposase 1154941..1155234 Streptococcus pyogenes MGAS2096 4065454 YP_600788.1 CDS MGAS2096_Spy1192 NC_008023.1 1155267 1155836 D transposase 1155267..1155836 Streptococcus pyogenes MGAS2096 4065455 YP_600789.1 CDS MGAS2096_Spy1193 NC_008023.1 1155876 1156097 D transposase 1155876..1156097 Streptococcus pyogenes MGAS2096 4065456 YP_600790.1 CDS MGAS2096_Spy1194 NC_008023.1 1156191 1156886 R CAAX amino protease complement(1156191..1156886) Streptococcus pyogenes MGAS2096 4065457 YP_600791.1 CDS MGAS2096_Spy1195 NC_008023.1 1156905 1157666 R hypothetical protein complement(1156905..1157666) Streptococcus pyogenes MGAS2096 4065458 YP_600792.1 CDS MGAS2096_Spy1196 NC_008023.1 1157663 1157893 R Cro/CI family transcriptional regulator complement(1157663..1157893) Streptococcus pyogenes MGAS2096 4065538 YP_600793.1 CDS MGAS2096_Spy1197 NC_008023.1 1157919 1158059 R hypothetical protein complement(1157919..1158059) Streptococcus pyogenes MGAS2096 4065539 YP_600794.1 CDS alaS NC_008023.1 1158238 1160856 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(1158238..1160856) Streptococcus pyogenes MGAS2096 4065540 YP_600795.1 CDS prsA NC_008023.1 1161243 1162298 R cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein; foldase PrsA complement(1161243..1162298) Streptococcus pyogenes MGAS2096 4065541 YP_600796.1 CDS MGAS2096_Spy1200 NC_008023.1 1162361 1163068 R O-methyltransferase complement(1162361..1163068) Streptococcus pyogenes MGAS2096 4065542 YP_600797.1 CDS MGAS2096_Spy1201 NC_008023.1 1163134 1164330 R major facilitator superfamily permease complement(1163134..1164330) Streptococcus pyogenes MGAS2096 4065543 YP_600798.1 CDS pepB NC_008023.1 1164706 1166511 R oligoendopeptidase F complement(1164706..1166511) Streptococcus pyogenes MGAS2096 4065544 YP_600799.1 CDS MGAS2096_Spy1203 NC_008023.1 1166524 1167486 R putative competence protein/transcription factor complement(1166524..1167486) Streptococcus pyogenes MGAS2096 4065545 YP_600800.1 CDS MGAS2096_Spy1204 NC_008023.1 1167781 1168497 R ribosomal small subunit pseudouridine synthase A complement(1167781..1168497) Streptococcus pyogenes MGAS2096 4065546 YP_600801.1 CDS nagB NC_008023.1 1168616 1169443 R glucosamine-6-phosphate isomerase complement(1168616..1169443) Streptococcus pyogenes MGAS2096 4065547 YP_600802.1 CDS queA NC_008023.1 1169522 1170550 D Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 1169522..1170550 Streptococcus pyogenes MGAS2096 4065548 YP_600803.1 CDS MGAS2096_Spy1207 NC_008023.1 1170557 1171777 D putative cytoplasmic protein 1170557..1171777 Streptococcus pyogenes MGAS2096 4065549 YP_600804.1 CDS MGAS2096_Spy1208 NC_008023.1 1171891 1172481 R hypothetical protein complement(1171891..1172481) Streptococcus pyogenes MGAS2096 4065550 YP_600805.1 CDS MGAS2096_Spy1209 NC_008023.1 1172478 1172726 R hypothetical protein complement(1172478..1172726) Streptococcus pyogenes MGAS2096 4065551 YP_600806.1 CDS MGAS2096_Spy1210 NC_008023.1 1172782 1172937 R hypothetical protein complement(1172782..1172937) Streptococcus pyogenes MGAS2096 4065552 YP_600807.1 CDS sodA NC_008023.1 1173104 1173709 R superoxide dismutase complement(1173104..1173709) Streptococcus pyogenes MGAS2096 4065553 YP_600808.1 CDS holA NC_008023.1 1173806 1174846 R required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta complement(1173806..1174846) Streptococcus pyogenes MGAS2096 4065554 YP_600809.1 CDS MGAS2096_Spy1213 NC_008023.1 1174917 1175078 R COME operon protein 3 complement(1174917..1175078) Streptococcus pyogenes MGAS2096 4065555 YP_600810.1 CDS comEC NC_008023.1 1175208 1177160 R COME operon protein 3 complement(1175208..1177160) Streptococcus pyogenes MGAS2096 4065556 YP_600811.1 CDS MGAS2096_Spy1215 NC_008023.1 1177361 1177804 R COME operon protein 1 complement(1177361..1177804) Streptococcus pyogenes MGAS2096 4065595 YP_600812.1 CDS MGAS2096_Spy1217 NC_008023.1 1178004 1178822 R 1-acyl-sn-glycerol-3-phosphate acyltransferase complement(1178004..1178822) Streptococcus pyogenes MGAS2096 4065596 YP_600813.1 CDS MGAS2096_Spy1216 NC_008023.1 1178784 1179638 D methyltransferase 1178784..1179638 Streptococcus pyogenes MGAS2096 4065597 YP_600814.1 CDS MGAS2096_Spy1218 NC_008023.1 1179628 1179906 D hypothetical protein 1179628..1179906 Streptococcus pyogenes MGAS2096 4065598 YP_600815.1 CDS MGAS2096_Spy1219 NC_008023.1 1179930 1180904 R Kup system potassium uptake protein complement(1179930..1180904) Streptococcus pyogenes MGAS2096 4065599 YP_600816.1 CDS MGAS2096_Spy1220 NC_008023.1 1180865 1181311 R Kup system potassium uptake protein complement(1180865..1181311) Streptococcus pyogenes MGAS2096 4065600 YP_600817.1 CDS MGAS2096_Spy1221 NC_008023.1 1181289 1181930 R Kup system potassium uptake protein complement(1181289..1181930) Streptococcus pyogenes MGAS2096 4065601 YP_600818.1 CDS MGAS2096_Spy1222 NC_008023.1 1182057 1182368 R ATP-dependent RNA helicase complement(1182057..1182368) Streptococcus pyogenes MGAS2096 4065602 YP_600819.1 CDS MGAS2096_Spy1223 NC_008023.1 1182286 1182456 R ATP-dependent RNA helicase complement(1182286..1182456) Streptococcus pyogenes MGAS2096 4065603 YP_600820.1 CDS deaD NC_008023.1 1182426 1183676 R ATP-dependent RNA helicase complement(1182426..1183676) Streptococcus pyogenes MGAS2096 4065604 YP_600821.1 CDS prfC NC_008023.1 1183983 1185527 R stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 complement(1183983..1185527) Streptococcus pyogenes MGAS2096 4065605 YP_600822.1 CDS MGAS2096_Spy1225 NC_008023.1 1185481 1185705 D hypothetical protein 1185481..1185705 Streptococcus pyogenes MGAS2096 4065606 YP_600823.1 CDS MGAS2096_Spy1227 NC_008023.1 1185775 1186470 R hypothetical protein complement(1185775..1186470) Streptococcus pyogenes MGAS2096 4065607 YP_600824.1 CDS murF NC_008023.1 1186551 1187942 R UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase complement(1186551..1187942) Streptococcus pyogenes MGAS2096 4065608 YP_600825.1 CDS ddl NC_008023.1 1188141 1189187 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(1188141..1189187) Streptococcus pyogenes MGAS2096 4065609 YP_600826.1 CDS recR NC_008023.1 1189288 1189884 R involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR complement(1189288..1189884) Streptococcus pyogenes MGAS2096 4065610 YP_600827.1 CDS MGAS2096_Spy1231 NC_008023.1 1189931 1190113 R penicillin-binding protein complement(1189931..1190113) Streptococcus pyogenes MGAS2096 4065611 YP_600828.1 CDS MGAS2096_Spy1232 NC_008023.1 1190672 1191196 R formate transporter complement(1190672..1191196) Streptococcus pyogenes MGAS2096 4065612 YP_600829.1 CDS MGAS2096_Spy1233 NC_008023.1 1191193 1191552 R formate transporter complement(1191193..1191552) Streptococcus pyogenes MGAS2096 4065613 YP_600830.1 CDS MGAS2096_Spy1234 NC_008023.1 1191574 1192116 R hypothetical protein complement(1191574..1192116) Streptococcus pyogenes MGAS2096 4065614 YP_600831.1 CDS MGAS2096_Spy1235 NC_008023.1 1192277 1192798 R biotin repressor family transcriptional regulator complement(1192277..1192798) Streptococcus pyogenes MGAS2096 4065693 YP_600832.1 CDS gpmA NC_008023.1 1192906 1193601 R 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase complement(1192906..1193601) Streptococcus pyogenes MGAS2096 4065694 YP_600833.1 CDS pyrD NC_008023.1 1193828 1194775 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; subclass 1A is a dimer formed by two identical PyrD subunits each containing an FMN group; dihydroorotate dehydrogenase 1A 1193828..1194775 Streptococcus pyogenes MGAS2096 4065695 YP_600834.1 CDS MGAS2096_Spy1238 NC_008023.1 1194830 1195003 R hypothetical protein complement(1194830..1195003) Streptococcus pyogenes MGAS2096 4065696 YP_600835.1 CDS MGAS2096_Spy1239 NC_008023.1 1195075 1195695 R lead, cadmium, zinc and mercury transporting ATPase complement(1195075..1195695) Streptococcus pyogenes MGAS2096 4065697 YP_600836.1 CDS MGAS2096_Spy1240 NC_008023.1 1195634 1196923 R lead, cadmium, zinc and mercury transporting ATPase complement(1195634..1196923) Streptococcus pyogenes MGAS2096 4065698 YP_600837.1 CDS MGAS2096_Spy1241 NC_008023.1 1197282 1197557 R DNA-binding protein HU complement(1197282..1197557) Streptococcus pyogenes MGAS2096 4065699 YP_600838.1 CDS MGAS2096_Spy1242 NC_008023.1 1197656 1198243 R hypothetical protein complement(1197656..1198243) Streptococcus pyogenes MGAS2096 4065700 YP_600839.1 CDS MGAS2096_Spy1243 NC_008023.1 1198221 1199081 R lipase/acylhydrolase complement(1198221..1199081) Streptococcus pyogenes MGAS2096 4065701 YP_600840.1 CDS MGAS2096_Spy1244 NC_008023.1 1199056 1199907 R DegV family fatty acid-binding protein complement(1199056..1199907) Streptococcus pyogenes MGAS2096 4065702 YP_600841.1 CDS MGAS2096_Spy1245 NC_008023.1 1200173 1201051 R hypothetical protein complement(1200173..1201051) Streptococcus pyogenes MGAS2096 4065703 YP_600842.1 CDS recN NC_008023.1 1201222 1202925 R DNA repair protein recN complement(1201222..1202925) Streptococcus pyogenes MGAS2096 4065704 YP_600843.1 CDS argR1 NC_008023.1 1202904 1203407 R arginine repressor ArgR complement(1202904..1203407) Streptococcus pyogenes MGAS2096 4065705 YP_600844.1 CDS MGAS2096_Spy1248 NC_008023.1 1203361 1204188 R lantibotic precursor complement(1203361..1204188) Streptococcus pyogenes MGAS2096 4065706 YP_600845.1 CDS fps NC_008023.1 1204181 1205053 R bifunctional; dimethylallyltransferase / geranyltranstransferase complement(1204181..1205053) Streptococcus pyogenes MGAS2096 4065707 YP_600846.1 CDS xseB NC_008023.1 1205053 1205268 R catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit complement(1205053..1205268) Streptococcus pyogenes MGAS2096 4065708 YP_600847.1 CDS xseA NC_008023.1 1205246 1206601 R bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit complement(1205246..1206601) Streptococcus pyogenes MGAS2096 4065709 YP_600848.1 CDS folD NC_008023.1 1206739 1207599 R catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase complement(1206739..1207599) Streptococcus pyogenes MGAS2096 4065710 YP_600849.1 CDS MGAS2096_Spy1253 NC_008023.1 1207801 1209504 R bifunctional; phosphoglucomutase/phosphomannomutase complement(1207801..1209504) Streptococcus pyogenes MGAS2096 4065711 YP_600850.1 CDS phr NC_008023.1 1209673 1211115 R deoxyribodipyrimidine photolyase complement(1209673..1211115) Streptococcus pyogenes MGAS2096 4065751 YP_600851.1 CDS artP NC_008023.1 1211231 1211968 R amino acid ABC transporter ATP-binding protein complement(1211231..1211968) Streptococcus pyogenes MGAS2096 4065752 YP_600852.1 CDS artQ NC_008023.1 1211965 1212651 R arginine ABC transporter permease complement(1211965..1212651) Streptococcus pyogenes MGAS2096 4065753 YP_600853.1 CDS MGAS2096_Spy1257 NC_008023.1 1212778 1213008 R putative cytoplasmic protein complement(1212778..1213008) Streptococcus pyogenes MGAS2096 4065754 YP_600854.1 CDS clpE NC_008023.1 1213306 1215588 D ATP-dependent endopeptidase Clp ATP-binding subunit clpE 1213306..1215588 Streptococcus pyogenes MGAS2096 4065755 YP_600855.1 CDS mutT NC_008023.1 1215716 1216171 D Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) 1215716..1216171 Streptococcus pyogenes MGAS2096 4065756 YP_600856.1 CDS MGAS2096_Spy1260 NC_008023.1 1216222 1216524 D putative cytoplasmic protein 1216222..1216524 Streptococcus pyogenes MGAS2096 4065757 YP_600857.1 CDS ileS NC_008023.1 1216788 1219589 R IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase complement(1216788..1219589) Streptococcus pyogenes MGAS2096 4065758 YP_600858.1 CDS divIVAS NC_008023.1 1219862 1220620 R cell division initiation protein DivIVA complement(1219862..1220620) Streptococcus pyogenes MGAS2096 4065759 YP_600859.1 CDS MGAS2096_Spy1263 NC_008023.1 1220630 1221421 R RNA binding protein complement(1220630..1221421) Streptococcus pyogenes MGAS2096 4065760 YP_600860.1 CDS MGAS2096_Spy1264 NC_008023.1 1221421 1221675 R integral membrane protein complement(1221421..1221675) Streptococcus pyogenes MGAS2096 4065761 YP_600861.1 CDS MGAS2096_Spy1265 NC_008023.1 1221680 1222348 R putative cytoplasmic protein complement(1221680..1222348) Streptococcus pyogenes MGAS2096 4065762 YP_600862.1 CDS MGAS2096_Spy1266 NC_008023.1 1222348 1223019 R pyridoxal-5'-phosphate family protein complement(1222348..1223019) Streptococcus pyogenes MGAS2096 4065763 YP_600863.1 CDS ftsZ NC_008023.1 1223022 1224341 R GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ complement(1223022..1224341) Streptococcus pyogenes MGAS2096 4065764 YP_600864.1 CDS ftsA NC_008023.1 1224365 1225729 R cell division protein ftsA complement(1224365..1225729) Streptococcus pyogenes MGAS2096 4065765 YP_600865.1 CDS MGAS2096_Spy1268 NC_008023.1 1225695 1225814 D hypothetical protein 1225695..1225814 Streptococcus pyogenes MGAS2096 4065766 YP_600866.1 CDS divIB NC_008023.1 1225941 1227089 R cell-division initiation protein DivIB complement(1225941..1227089) Streptococcus pyogenes MGAS2096 4065767 YP_600867.1 CDS murG NC_008023.1 1227090 1228193 R UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase complement(1227090..1228193) Streptococcus pyogenes MGAS2096 4065768 YP_600868.1 CDS murD NC_008023.1 1228172 1229530 R UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase complement(1228172..1229530) Streptococcus pyogenes MGAS2096 4065769 YP_600869.1 CDS MGAS2096_Spy1273 NC_008023.1 1229886 1230137 R hypothetical protein complement(1229886..1230137) Streptococcus pyogenes MGAS2096 4065770 YP_600870.1 CDS typA NC_008023.1 1230259 1231875 R GTP-binding protein TypA/BipA complement(1230259..1231875) Streptococcus pyogenes MGAS2096 4064577 YP_600871.1 CDS MGAS2096_Spy1275 NC_008023.1 1231898 1232101 R GTP-binding protein TypA/BipA complement(1231898..1232101) Streptococcus pyogenes MGAS2096 4064578 YP_600872.1 CDS MGAS2096_Spy1276 NC_008023.1 1232283 1232672 R rhodanese-related sulfurtransferases complement(1232283..1232672) Streptococcus pyogenes MGAS2096 4064579 YP_600873.1 CDS glcK NC_008023.1 1232682 1233653 R glucokinase complement(1232682..1233653) Streptococcus pyogenes MGAS2096 4064580 YP_600874.1 CDS MGAS2096_Spy1278 NC_008023.1 1233658 1233879 R putative cytoplasmic protein complement(1233658..1233879) Streptococcus pyogenes MGAS2096 4064581 YP_600875.1 CDS dpr NC_008023.1 1234003 1234530 R non-specific DNA-binding protein Dps / Iron-binding ferritin-like antioxidant protein / ferroxidase complement(1234003..1234530) Streptococcus pyogenes MGAS2096 4064582 YP_600876.1 CDS MGAS2096_Spy1280 NC_008023.1 1234758 1235384 D Type 4 prepilin peptidase pilD 1234758..1235384 Streptococcus pyogenes MGAS2096 4064583 YP_600877.1 CDS MGAS2096_Spy1281 NC_008023.1 1235466 1236545 R 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N complement(1235466..1236545) Streptococcus pyogenes MGAS2096 4064584 YP_600878.1 CDS MGAS2096_Spy1282 NC_008023.1 1236549 1237193 R putative cytoplasmic protein complement(1236549..1237193) Streptococcus pyogenes MGAS2096 4064585 YP_600879.1 CDS MGAS2096_Spy1283 NC_008023.1 1237464 1237586 R hypothetical protein complement(1237464..1237586) Streptococcus pyogenes MGAS2096 4064586 YP_600880.1 CDS MGAS2096_Spy1284 NC_008023.1 1237617 1238642 R ribose operon repressor complement(1237617..1238642) Streptococcus pyogenes MGAS2096 4064587 YP_600881.1 CDS MGAS2096_Spy1285 NC_008023.1 1238999 1240036 R ATP-dependent endopeptidase Lon complement(1238999..1240036) Streptococcus pyogenes MGAS2096 4064588 YP_600882.1 CDS coaD NC_008023.1 1240023 1240514 R Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase complement(1240023..1240514) Streptococcus pyogenes MGAS2096 4064589 YP_600883.1 CDS MGAS2096_Spy1287 NC_008023.1 1240504 1241043 R methyltransferase complement(1240504..1241043) Streptococcus pyogenes MGAS2096 4064590 YP_600884.1 CDS asnA NC_008023.1 1241166 1242158 R catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA complement(1241166..1242158) Streptococcus pyogenes MGAS2096 4064591 YP_600885.1 CDS arcC NC_008023.1 1242472 1243422 R catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase complement(1242472..1243422) Streptococcus pyogenes MGAS2096 4064592 YP_600886.1 CDS MGAS2096_Spy1290 NC_008023.1 1243442 1244773 R hypothetical protein complement(1243442..1244773) Streptococcus pyogenes MGAS2096 4064593 YP_600887.1 CDS MGAS2096_Spy1291 NC_008023.1 1244790 1246283 R arginine/ornithine antiporter complement(1244790..1246283) Streptococcus pyogenes MGAS2096 4064594 YP_600888.1 CDS arcB NC_008023.1 1246453 1247466 R catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase complement(1246453..1247466) Streptococcus pyogenes MGAS2096 4064595 YP_600889.1 CDS MGAS2096_Spy1293 NC_008023.1 1247506 1247817 R acetyltransferase complement(1247506..1247817) Streptococcus pyogenes MGAS2096 4065097 YP_600890.1 CDS arcA NC_008023.1 1247898 1249133 R catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase complement(1247898..1249133) Streptococcus pyogenes MGAS2096 4065098 YP_600891.1 CDS MGAS2096_Spy1295 NC_008023.1 1249407 1250087 R Crp family transcriptional regulator complement(1249407..1250087) Streptococcus pyogenes MGAS2096 4065099 YP_600892.1 CDS ahrC2 NC_008023.1 1250229 1250702 D arginine repressor ArgR 1250229..1250702 Streptococcus pyogenes MGAS2096 4065100 YP_600893.1 CDS MGAS2096_Spy1297 NC_008023.1 1250868 1251584 R hypothetical protein complement(1250868..1251584) Streptococcus pyogenes MGAS2096 4065101 YP_600894.1 CDS MGAS2096_Spy1298 NC_008023.1 1251607 1252686 R putative cytoplasmic protein complement(1251607..1252686) Streptococcus pyogenes MGAS2096 4065102 YP_600895.1 CDS MGAS2096_Spy1299 NC_008023.1 1252759 1254492 R two-component sensor kinase yesM complement(1252759..1254492) Streptococcus pyogenes MGAS2096 4065103 YP_600896.1 CDS MGAS2096_Spy1300 NC_008023.1 1254489 1255229 R two-component response regulator yesN complement(1254489..1255229) Streptococcus pyogenes MGAS2096 4065104 YP_600897.1 CDS msrA NC_008023.1 1255317 1256423 R bifunctional methionine sulfoxide reductase A/B complement(1255317..1256423) Streptococcus pyogenes MGAS2096 4065105 YP_600898.1 CDS tlpA NC_008023.1 1256466 1257089 R Thiol:disulfide interchange protein tlpA complement(1256466..1257089) Streptococcus pyogenes MGAS2096 4065106 YP_600899.1 CDS ccdA NC_008023.1 1257102 1257812 R cytochrome c-type biogenesis protein ccdA complement(1257102..1257812) Streptococcus pyogenes MGAS2096 4065107 YP_600900.1 CDS MGAS2096_Spy1304 NC_008023.1 1258552 1258845 R putative cytoplasmic protein complement(1258552..1258845) Streptococcus pyogenes MGAS2096 4065108 YP_600901.1 CDS MGAS2096_Spy1305 NC_008023.1 1258856 1259881 R hypothetical protein complement(1258856..1259881) Streptococcus pyogenes MGAS2096 4065109 YP_600902.1 CDS MGAS2096_Spy1306 NC_008023.1 1259878 1260552 R hypothetical protein complement(1259878..1260552) Streptococcus pyogenes MGAS2096 4065110 YP_600903.1 CDS MGAS2096_Spy1307 NC_008023.1 1260554 1261417 R putative cytoplasmic protein complement(1260554..1261417) Streptococcus pyogenes MGAS2096 4065111 YP_600904.1 CDS MGAS2096_Spy1308 NC_008023.1 1261407 1263302 R hypothetical protein complement(1261407..1263302) Streptococcus pyogenes MGAS2096 4065112 YP_600905.1 CDS MGAS2096_Spy1309 NC_008023.1 1263302 1264030 R hypothetical protein complement(1263302..1264030) Streptococcus pyogenes MGAS2096 4065113 YP_600906.1 CDS MGAS2096_Spy1310 NC_008023.1 1264163 1266571 R ATP-dependent RNA helicase complement(1264163..1266571) Streptococcus pyogenes MGAS2096 4065114 YP_600907.1 CDS valS NC_008023.1 1266725 1269373 R valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase complement(1266725..1269373) Streptococcus pyogenes MGAS2096 4065115 YP_600908.1 CDS MGAS2096_Spy1312 NC_008023.1 1269375 1269959 R hypothetical protein complement(1269375..1269959) Streptococcus pyogenes MGAS2096 4065116 YP_600909.1 CDS MGAS2096_Spy1313 NC_008023.1 1269935 1270114 R ribosomal-protein-serine acetyltransferase complement(1269935..1270114) Streptococcus pyogenes MGAS2096 4064502 YP_600910.1 CDS MGAS2096_Spy1314 NC_008023.1 1270539 1270934 R putative cytoplasmic protein complement(1270539..1270934) Streptococcus pyogenes MGAS2096 4064503 YP_600911.1 CDS MGAS2096_Spy1315 NC_008023.1 1270955 1271209 R hypothetical protein complement(1270955..1271209) Streptococcus pyogenes MGAS2096 4064504 YP_600912.1 CDS MGAS2096_Spy1316 NC_008023.1 1271686 1272438 D catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; 3-deoxy-7-phosphoheptulonate synthase 1271686..1272438 Streptococcus pyogenes MGAS2096 4064506 YP_600913.1 CDS aroB NC_008023.1 1272479 1273567 D catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 1272479..1273567 Streptococcus pyogenes MGAS2096 4064507 YP_600914.1 CDS MGAS2096_Spy1318 NC_008023.1 1273852 1273995 R hypothetical protein complement(1273852..1273995) Streptococcus pyogenes MGAS2096 4064508 YP_600915.1 CDS MGAS2096_Spy1319 NC_008023.1 1274003 1274308 R putative acetate kinase complement(1274003..1274308) Streptococcus pyogenes MGAS2096 4064509 YP_600916.1 CDS MGAS2096_Spy1320 NC_008023.1 1274310 1274648 R putative cytoplasmic protein complement(1274310..1274648) Streptococcus pyogenes MGAS2096 4064510 YP_600917.1 CDS MGAS2096_Spy1321 NC_008023.1 1274701 1275456 R SAM-dependent methyltransferase complement(1274701..1275456) Streptococcus pyogenes MGAS2096 4064511 YP_600918.1 CDS MGAS2096_Spy1322 NC_008023.1 1275553 1275660 D hypothetical protein 1275553..1275660 Streptococcus pyogenes MGAS2096 4064512 YP_600919.1 CDS aroE NC_008023.1 1275691 1276569 R shikimate 5-dehydrogenase complement(1275691..1276569) Streptococcus pyogenes MGAS2096 4064513 YP_600920.1 CDS lacZ NC_008023.1 1276707 1280213 R beta-galactosidase complement(1276707..1280213) Streptococcus pyogenes MGAS2096 4064514 YP_600921.1 CDS MGAS2096_Spy1325 NC_008023.1 1280143 1281630 R two-component response regulator yesN complement(1280143..1281630) Streptococcus pyogenes MGAS2096 4064515 YP_600922.1 CDS MGAS2096_Spy1326 NC_008023.1 1281627 1283354 R two-component sensor kinase yesM complement(1281627..1283354) Streptococcus pyogenes MGAS2096 4064516 YP_600923.1 CDS MGAS2096_Spy1327 NC_008023.1 1283341 1283946 R hypothetical protein complement(1283341..1283946) Streptococcus pyogenes MGAS2096 4064517 YP_600924.1 CDS MGAS2096_Spy1328 NC_008023.1 1284251 1285696 R sugar-binding protein complement(1284251..1285696) Streptococcus pyogenes MGAS2096 4064518 YP_600925.1 CDS MGAS2096_Spy1329 NC_008023.1 1285777 1286703 R sugar transport system permease complement(1285777..1286703) Streptococcus pyogenes MGAS2096 4064519 YP_600926.1 CDS MGAS2096_Spy1330 NC_008023.1 1286713 1287711 R sugar transport system permease complement(1286713..1287711) Streptococcus pyogenes MGAS2096 4064520 YP_600927.1 CDS MGAS2096_Spy1331 NC_008023.1 1287814 1288737 D RpiR family transcriptional regulator 1287814..1288737 Streptococcus pyogenes MGAS2096 4064521 YP_600928.1 CDS MGAS2096_Spy1332 NC_008023.1 1288880 1289002 D hypothetical protein 1288880..1289002 Streptococcus pyogenes MGAS2096 4064522 YP_600929.1 CDS MGAS2096_Spy1333 NC_008023.1 1289348 1290790 R Beta-glucosidase complement(1289348..1290790) Streptococcus pyogenes MGAS2096 4064523 YP_600930.1 CDS hyl NC_008023.1 1290815 1291954 R hyaluronoglucosaminidase complement(1290815..1291954) Streptococcus pyogenes MGAS2096 4064524 YP_600931.1 CDS MGAS2096_Spy1335 NC_008023.1 1291951 1292508 R putative cytoplasmic protein complement(1291951..1292508) Streptococcus pyogenes MGAS2096 4064525 YP_600932.1 CDS MGAS2096_Spy1336 NC_008023.1 1292559 1293599 R GntR family transcriptional regulator complement(1292559..1293599) Streptococcus pyogenes MGAS2096 4064526 YP_600933.1 CDS MGAS2096_Spy1337 NC_008023.1 1293705 1295018 D hypothetical protein 1293705..1295018 Streptococcus pyogenes MGAS2096 4064527 YP_600934.1 CDS MGAS2096_Spy1338 NC_008023.1 1295033 1297738 D Alpha-mannosidase 1295033..1297738 Streptococcus pyogenes MGAS2096 4064528 YP_600935.1 CDS rocA NC_008023.1 1297839 1299137 R sensory transduction protein kinase complement(1297839..1299137) Streptococcus pyogenes MGAS2096 4064529 YP_600936.1 CDS MGAS2096_Spy1340 NC_008023.1 1299859 1301214 R tRNA (Uracil-5-) -methyltransferase complement(1299859..1301214) Streptococcus pyogenes MGAS2096 4064530 YP_600937.1 CDS recX NC_008023.1 1301329 1302105 D binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1301329..1302105 Streptococcus pyogenes MGAS2096 4064531 YP_600938.1 CDS MGAS2096_Spy1342 NC_008023.1 1302185 1302718 D hypothetical protein 1302185..1302718 Streptococcus pyogenes MGAS2096 4064532 YP_600939.1 CDS MGAS2096_Spy1343 NC_008023.1 1302850 1302975 D hypothetical protein 1302850..1302975 Streptococcus pyogenes MGAS2096 4064533 YP_600940.1 CDS MGAS2096_Spy1344 NC_008023.1 1303090 1303476 D transposase 1303090..1303476 Streptococcus pyogenes MGAS2096 4064534 YP_600941.1 CDS MGAS2096_Spy1345 NC_008023.1 1309657 1309881 D hypothetical protein 1309657..1309881 Streptococcus pyogenes MGAS2096 4065330 YP_600942.1 CDS MGAS2096_Spy1346 NC_008023.1 1310475 1311023 R ribosome-associated factor Y complement(1310475..1311023) Streptococcus pyogenes MGAS2096 4065331 YP_600943.1 CDS comFC NC_008023.1 1311103 1311768 R COMF operon protein 3 complement(1311103..1311768) Streptococcus pyogenes MGAS2096 4064713 YP_600944.1 CDS comFA NC_008023.1 1311740 1313065 R COMF operon protein 1 complement(1311740..1313065) Streptococcus pyogenes MGAS2096 4064714 YP_600945.1 CDS MGAS2096_Spy1349 NC_008023.1 1313105 1313752 D Xaa-Pro dipeptidase 1313105..1313752 Streptococcus pyogenes MGAS2096 4064715 YP_600946.1 CDS cysM NC_008023.1 1313880 1314821 D cysteine synthase 1313880..1314821 Streptococcus pyogenes MGAS2096 4064716 YP_600947.1 CDS MGAS2096_Spy1351 NC_008023.1 1314839 1315216 R hypothetical protein complement(1314839..1315216) Streptococcus pyogenes MGAS2096 4064717 YP_600948.1 CDS MGAS2096_Spy1352 NC_008023.1 1315216 1316628 R peptidyl-prolyl cis-trans isomerase complement(1315216..1316628) Streptococcus pyogenes MGAS2096 4064718 YP_600949.1 CDS yvqC NC_008023.1 1316653 1317300 R two-component response regulator yvqC complement(1316653..1317300) Streptococcus pyogenes MGAS2096 4064719 YP_600950.1 CDS yvqE NC_008023.1 1317287 1318291 R two-component sensor protein yvqE complement(1317287..1318291) Streptococcus pyogenes MGAS2096 4064720 YP_600951.1 CDS yvqF NC_008023.1 1318288 1319031 R transporter yvqF complement(1318288..1319031) Streptococcus pyogenes MGAS2096 4064721 YP_600952.1 CDS MGAS2096_Spy1356 NC_008023.1 1319103 1321001 R Serine/threonine protein kinase complement(1319103..1321001) Streptococcus pyogenes MGAS2096 4064722 YP_600953.1 CDS pppL NC_008023.1 1320998 1321738 R protein phosphatase 2C complement(1320998..1321738) Streptococcus pyogenes MGAS2096 4064723 YP_600954.1 CDS sunL NC_008023.1 1321776 1323098 R 16S rRNA m(5)C 967 methyltransferase complement(1321776..1323098) Streptococcus pyogenes MGAS2096 4064724 YP_600955.1 CDS fmt NC_008023.1 1323088 1324023 R modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase complement(1323088..1324023) Streptococcus pyogenes MGAS2096 4064725 YP_600956.1 CDS priA NC_008023.1 1324085 1326496 R binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA complement(1324085..1326496) Streptococcus pyogenes MGAS2096 4064726 YP_600957.1 CDS MGAS2096_Spy1361 NC_008023.1 1326534 1326851 R Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega complement(1326534..1326851) Streptococcus pyogenes MGAS2096 4064727 YP_600958.1 CDS gmk NC_008023.1 1326867 1327502 R Essential for recycling GMP and indirectly, cGMP; guanylate kinase complement(1326867..1327502) Streptococcus pyogenes MGAS2096 4064728 YP_600959.1 CDS MGAS2096_Spy1363 NC_008023.1 1327612 1329219 R HAD superfamily; hypothetical protein complement(1327612..1329219) Streptococcus pyogenes MGAS2096 4064729 YP_600960.1 CDS MGAS2096_Spy1364 NC_008023.1 1329349 1330269 R LysR family transcriptional regulator complement(1329349..1330269) Streptococcus pyogenes MGAS2096 4064730 YP_600961.1 CDS atoB NC_008023.1 1330446 1331633 D Acetyl-CoA acetyltransferase 1330446..1331633 Streptococcus pyogenes MGAS2096 4064731 YP_600962.1 CDS atoD1 NC_008023.1 1331645 1332307 D acetate CoA-transferase subunit alpha 1331645..1332307 Streptococcus pyogenes MGAS2096 4065195 YP_600963.1 CDS atoA NC_008023.1 1332309 1332968 D acetate CoA-transferase subunit beta 1332309..1332968 Streptococcus pyogenes MGAS2096 4065196 YP_600964.1 CDS MGAS2096_Spy1368 NC_008023.1 1333020 1333778 D catalyzes the formation of acetoacetate from 3-hydroxybutyrate; 3-hydroxybutyrate dehydrogenase 1333020..1333778 Streptococcus pyogenes MGAS2096 4065197 YP_600965.1 CDS MGAS2096_Spy1369 NC_008023.1 1333849 1334289 D D-beta-hydroxybutyrate permease 1333849..1334289 Streptococcus pyogenes MGAS2096 4065198 YP_600966.1 CDS MGAS2096_Spy1370 NC_008023.1 1334335 1335180 D D-beta-hydroxybutyrate permease 1334335..1335180 Streptococcus pyogenes MGAS2096 4065199 YP_600967.1 CDS luxS NC_008023.1 1335164 1335736 D catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 1335164..1335736 Streptococcus pyogenes MGAS2096 4065200 YP_600968.1 CDS MGAS2096_Spy1372 NC_008023.1 1335882 1337351 R hypothetical protein complement(1335882..1337351) Streptococcus pyogenes MGAS2096 4065201 YP_600969.1 CDS MGAS2096_Spy1373 NC_008023.1 1337365 1338519 R methyltransferase complement(1337365..1338519) Streptococcus pyogenes MGAS2096 4065202 YP_600970.1 CDS MGAS2096_Spy1374 NC_008023.1 1338964 1339290 R cell division initiation protein DivIVA complement(1338964..1339290) Streptococcus pyogenes MGAS2096 4065203 YP_600971.1 CDS MGAS2096_Spy1375 NC_008023.1 1339412 1339927 R hypothetical protein complement(1339412..1339927) Streptococcus pyogenes MGAS2096 4065204 YP_600972.1 CDS recU NC_008023.1 1340008 1340616 D functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC; Holliday junction-specific endonuclease 1340008..1340616 Streptococcus pyogenes MGAS2096 4065205 YP_600973.1 CDS pbp1A NC_008023.1 1340603 1342768 D multimodular transpeptidase-transglycosylase PBP 1A 1340603..1342768 Streptococcus pyogenes MGAS2096 4065206 YP_600974.1 CDS pepC NC_008023.1 1343232 1344569 R aminopeptidase C complement(1343232..1344569) Streptococcus pyogenes MGAS2096 4065207 YP_600975.1 CDS nadE NC_008023.1 1344754 1345620 R catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase complement(1344754..1345620) Streptococcus pyogenes MGAS2096 4065208 YP_600976.1 CDS nadE NC_008023.1 1345580 1347034 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase complement(1345580..1347034) Streptococcus pyogenes MGAS2096 4065209 YP_600977.1 CDS MGAS2096_Spy1381 NC_008023.1 1347205 1348596 R amino acid permease complement(1347205..1348596) Streptococcus pyogenes MGAS2096 4065210 YP_600978.1 CDS MGAS2096_Spy1382 NC_008023.1 1348753 1349670 R thioredoxin reductase complement(1348753..1349670) Streptococcus pyogenes MGAS2096 4065211 YP_600979.1 CDS aapA NC_008023.1 1349734 1349958 R hypothetical protein complement(1349734..1349958) Streptococcus pyogenes MGAS2096 4065212 YP_600980.1 CDS MGAS2096_Spy1384 NC_008023.1 1350062 1350808 R amino acid ABC transporter ATP-binding protein complement(1350062..1350808) Streptococcus pyogenes MGAS2096 4065213 YP_600981.1 CDS MGAS2096_Spy1385 NC_008023.1 1350805 1351698 R amino acid ABC transporter permease complement(1350805..1351698) Streptococcus pyogenes MGAS2096 4065214 YP_600982.1 CDS MGAS2096_Spy1387 NC_008023.1 1351803 1353146 R ATP-dependent RNA helicase complement(1351803..1353146) Streptococcus pyogenes MGAS2096 4066307 YP_600983.1 CDS MGAS2096_Spy1386 NC_008023.1 1353145 1353294 D hypothetical protein 1353145..1353294 Streptococcus pyogenes MGAS2096 4066308 YP_600984.1 CDS mraY NC_008023.1 1353304 1354314 R First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase complement(1353304..1354314) Streptococcus pyogenes MGAS2096 4066309 YP_600985.1 CDS MGAS2096_Spy1389 NC_008023.1 1354316 1356571 R division specific D,D-transpeptidase / cell division protein ftsI complement(1354316..1356571) Streptococcus pyogenes MGAS2096 4066310 YP_600986.1 CDS ftsL NC_008023.1 1356575 1356928 R cell division protein ftsL complement(1356575..1356928) Streptococcus pyogenes MGAS2096 4066311 YP_600987.1 CDS mraW NC_008023.1 1356903 1357916 R S-adenosyl-methyltransferase MraW complement(1356903..1357916) Streptococcus pyogenes MGAS2096 4066312 YP_600988.1 CDS MGAS2096_Spy1392 NC_008023.1 1358146 1358412 R hypothetical protein complement(1358146..1358412) Streptococcus pyogenes MGAS2096 4066313 YP_600989.1 CDS proA NC_008023.1 1358387 1359637 R Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase complement(1358387..1359637) Streptococcus pyogenes MGAS2096 4066314 YP_600990.1 CDS MGAS2096_Spy1394 NC_008023.1 1359630 1360457 R catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase complement(1359630..1360457) Streptococcus pyogenes MGAS2096 4066315 YP_600991.1 CDS proB NC_008023.1 1360515 1362185 R ABC transporter permease complement(1360515..1362185) Streptococcus pyogenes MGAS2096 4066316 YP_600992.1 CDS MGAS2096_Spy1396 NC_008023.1 1362148 1362882 R ABC transporter ATP-binding protein complement(1362148..1362882) Streptococcus pyogenes MGAS2096 4066317 YP_600993.1 CDS MGAS2096_Spy1397 NC_008023.1 1362916 1363182 R hypothetical protein complement(1362916..1363182) Streptococcus pyogenes MGAS2096 4066318 YP_600994.2 CDS tkt NC_008023.1 1363375 1365360 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(1363375..1365360) Streptococcus pyogenes MGAS2096 4066319 YP_600995.1 CDS MGAS2096_Spy1399 NC_008023.1 1365578 1366222 R similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity; putative translaldolase complement(1365578..1366222) Streptococcus pyogenes MGAS2096 4066320 YP_600996.1 CDS MGAS2096_Spy1400 NC_008023.1 1366348 1367907 R trans-acting positive regulator complement(1366348..1367907) Streptococcus pyogenes MGAS2096 4066321 YP_600997.1 CDS MGAS2096_Spy1401 NC_008023.1 1367837 1369276 R NADH peroxidase complement(1367837..1369276) Streptococcus pyogenes MGAS2096 4066322 YP_600998.1 CDS glpF NC_008023.1 1369292 1369993 R glycerol uptake facilitator protein complement(1369292..1369993) Streptococcus pyogenes MGAS2096 4066323 YP_600999.1 CDS glpO NC_008023.1 1369995 1371833 R Alpha-glycerophosphate oxidase complement(1369995..1371833) Streptococcus pyogenes MGAS2096 4066324 YP_601000.1 CDS glpK NC_008023.1 1371849 1373375 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(1371849..1373375) Streptococcus pyogenes MGAS2096 4066325 YP_601001.1 CDS MGAS2096_Spy1405 NC_008023.1 1373735 1374187 R hypothetical protein complement(1373735..1374187) Streptococcus pyogenes MGAS2096 4064844 YP_601002.1 CDS MGAS2096_Spy1406 NC_008023.1 1374254 1374511 R hypothetical protein complement(1374254..1374511) Streptococcus pyogenes MGAS2096 4064845 YP_601003.1 CDS glyS NC_008023.1 1374665 1376617 R glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta complement(1374665..1376617) Streptococcus pyogenes MGAS2096 4064846 YP_601004.1 CDS glyQ NC_008023.1 1377081 1377998 R glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha complement(1377081..1377998) Streptococcus pyogenes MGAS2096 4064847 YP_601005.1 CDS MGAS2096_Spy1409 NC_008023.1 1377962 1378168 R hypothetical protein complement(1377962..1378168) Streptococcus pyogenes MGAS2096 4064848 YP_601006.1 CDS MGAS2096_Spy1410 NC_008023.1 1378369 1378923 R hypothetical protein complement(1378369..1378923) Streptococcus pyogenes MGAS2096 4064849 YP_601007.1 CDS MGAS2096_Spy1411 NC_008023.1 1379034 1379876 R aldo/keto reductase complement(1379034..1379876) Streptococcus pyogenes MGAS2096 4064850 YP_601008.1 CDS nagA NC_008023.1 1379995 1381143 R N-acetylglucosamine-6-phosphate deacetylase complement(1379995..1381143) Streptococcus pyogenes MGAS2096 4064851 YP_601009.1 CDS MGAS2096_Spy1413 NC_008023.1 1381261 1382910 R Sodium-dependent phosphate transporter complement(1381261..1382910) Streptococcus pyogenes MGAS2096 4064852 YP_601010.1 CDS MGAS2096_Spy1415 NC_008023.1 1382950 1383117 R hypothetical protein complement(1382950..1383117) Streptococcus pyogenes MGAS2096 4064853 YP_601011.1 CDS MGAS2096_Spy1414 NC_008023.1 1383094 1383816 D hypothetical protein 1383094..1383816 Streptococcus pyogenes MGAS2096 4064854 YP_601012.1 CDS MGAS2096_Spy1416 NC_008023.1 1383962 1384786 R DegV family protein complement(1383962..1384786) Streptococcus pyogenes MGAS2096 4064855 YP_601013.1 CDS MGAS2096_Spy1417 NC_008023.1 1385076 1385636 D TetR family transcriptional regulator 1385076..1385636 Streptococcus pyogenes MGAS2096 4064856 YP_601014.1 CDS MGAS2096_Spy1418 NC_008023.1 1385672 1386553 R HAD superfamily; hydrolase complement(1385672..1386553) Streptococcus pyogenes MGAS2096 4064857 YP_601015.1 CDS MGAS2096_Spy1419 NC_008023.1 1386498 1387115 R hypothetical protein complement(1386498..1387115) Streptococcus pyogenes MGAS2096 4064858 YP_601016.1 CDS lacD1 NC_008023.1 1387312 1388289 R catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; tagatose 1,6-diphosphate aldolase complement(1387312..1388289) Streptococcus pyogenes MGAS2096 4064859 YP_601017.1 CDS MGAS2096_Spy1421 NC_008023.1 1388371 1388634 R tagatose-6-phosphate kinase complement(1388371..1388634) Streptococcus pyogenes MGAS2096 4064860 YP_601018.1 CDS lacB1 NC_008023.1 1388788 1389204 R galactose-6-phosphate isomerase subunit LacB complement(1388788..1389204) Streptococcus pyogenes MGAS2096 4064861 YP_601019.1 CDS lacA1 NC_008023.1 1389219 1389644 R catalyzes the interconversion of galactose 6-phosphate to tagatose; galactose-6-phosphate isomerase subunit LacA complement(1389219..1389644) Streptococcus pyogenes MGAS2096 4064862 YP_601020.1 CDS MGAS2096_Spy1424 NC_008023.1 1389723 1389899 D putative transcriptional regulator 1389723..1389899 Streptococcus pyogenes MGAS2096 4064863 YP_601021.1 CDS MGAS2096_Spy1425 NC_008023.1 1389902 1390333 R PTS system galactose-specific transporter subunit IIC complement(1389902..1390333) Streptococcus pyogenes MGAS2096 4066459 YP_601022.1 CDS MGAS2096_Spy1426 NC_008023.1 1390330 1391352 R PTS system galactose-specific transporter subunit IIC complement(1390330..1391352) Streptococcus pyogenes MGAS2096 4066460 YP_601023.1 CDS MGAS2096_Spy1427 NC_008023.1 1391378 1391683 R PTS system galactose-specific transporter subunit IIB complement(1391378..1391683) Streptococcus pyogenes MGAS2096 4066461 YP_601024.1 CDS MGAS2096_Spy1428 NC_008023.1 1391676 1392035 R PTS system galactose-specific transporter subunit IIA complement(1391676..1392035) Streptococcus pyogenes MGAS2096 4066462 YP_601025.1 CDS lacR1 NC_008023.1 1392385 1393155 D lactose phosphotransferase system repressor 1392385..1393155 Streptococcus pyogenes MGAS2096 4066463 YP_601026.1 CDS copZ NC_008023.1 1393355 1393558 R copper chaperone copZ complement(1393355..1393558) Streptococcus pyogenes MGAS2096 4066464 YP_601027.1 CDS copA NC_008023.1 1393572 1395848 R copper-exporting ATPase complement(1393572..1395848) Streptococcus pyogenes MGAS2096 4066465 YP_601028.1 CDS copY NC_008023.1 1395803 1396255 R CopAB ATPase metal-fist type repressor complement(1395803..1396255) Streptococcus pyogenes MGAS2096 4066466 YP_601029.1 CDS MGAS2096_Spy1433 NC_008023.1 1396409 1397398 D esterase 1396409..1397398 Streptococcus pyogenes MGAS2096 4066467 YP_601030.1 CDS rbfA NC_008023.1 1397529 1397885 R associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A complement(1397529..1397885) Streptococcus pyogenes MGAS2096 4066468 YP_601031.1 CDS infB NC_008023.1 1398085 1400946 R Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 complement(1398085..1400946) Streptococcus pyogenes MGAS2096 4066469 YP_601032.1 CDS MGAS2096_Spy1436 NC_008023.1 1400966 1401268 R hypothetical protein complement(1400966..1401268) Streptococcus pyogenes MGAS2096 4066470 YP_601033.1 CDS MGAS2096_Spy1437 NC_008023.1 1401261 1401560 R putative cytoplasmic protein complement(1401261..1401560) Streptococcus pyogenes MGAS2096 4066471 YP_601034.2 CDS nusA NC_008023.1 1401573 1402730 R modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA complement(1401573..1402730) Streptococcus pyogenes MGAS2096 4066472 YP_601035.1 CDS MGAS2096_Spy1439 NC_008023.1 1402905 1403441 R in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein complement(1402905..1403441) Streptococcus pyogenes MGAS2096 4066473 YP_601036.1 CDS MGAS2096_Spy1440 NC_008023.1 1403686 1403865 R phage protein complement(1403686..1403865) Streptococcus pyogenes MGAS2096 4066474 YP_601037.1 CDS sdaD2 NC_008023.1 1404104 1405276 D deoxyribonuclease precursor 1404104..1405276 Streptococcus pyogenes MGAS2096 4066475 YP_601038.1 CDS MGAS2096_Spy1442 NC_008023.1 1405392 1406588 R phage-associated cell wall hydrolase complement(1405392..1406588) Streptococcus pyogenes MGAS2096 4066476 YP_601039.1 CDS MGAS2096_Spy1443 NC_008023.1 1406699 1406884 R phage protein complement(1406699..1406884) Streptococcus pyogenes MGAS2096 4066477 YP_601040.1 CDS MGAS2096_Spy1444 NC_008023.1 1406881 1407180 R phage protein complement(1406881..1407180) Streptococcus pyogenes MGAS2096 4065077 YP_601041.1 CDS MGAS2096_Spy1445 NC_008023.1 1407191 1407811 R phage protein complement(1407191..1407811) Streptococcus pyogenes MGAS2096 4065078 YP_601042.1 CDS MGAS2096_Spy1446 NC_008023.1 1407814 1407975 R phage protein complement(1407814..1407975) Streptococcus pyogenes MGAS2096 4065079 YP_601043.1 CDS MGAS2096_Spy1447 NC_008023.1 1407984 1409891 R phage infection protein complement(1407984..1409891) Streptococcus pyogenes MGAS2096 4065080 YP_601044.1 CDS MGAS2096_Spy1448 NC_008023.1 1409902 1410537 R phage protein complement(1409902..1410537) Streptococcus pyogenes MGAS2096 4065081 YP_601045.1 CDS MGAS2096_Spy1449 NC_008023.1 1410537 1411592 R hyaluronoglucosaminidase complement(1410537..1411592) Streptococcus pyogenes MGAS2096 4065082 YP_601046.1 CDS MGAS2096_Spy1450 NC_008023.1 1411589 1413571 R phage endopeptidase complement(1411589..1413571) Streptococcus pyogenes MGAS2096 4065083 YP_601047.1 CDS MGAS2096_Spy1451 NC_008023.1 1413581 1414423 R phage protein complement(1413581..1414423) Streptococcus pyogenes MGAS2096 4065084 YP_601048.1 CDS MGAS2096_Spy1452 NC_008023.1 1414435 1418817 R phage protein complement(1414435..1418817) Streptococcus pyogenes MGAS2096 4065085 YP_601049.1 CDS MGAS2096_Spy1453 NC_008023.1 1418832 1419065 R phage protein complement(1418832..1419065) Streptococcus pyogenes MGAS2096 4065086 YP_601050.1 CDS MGAS2096_Spy1454 NC_008023.1 1419140 1419595 R phage protein complement(1419140..1419595) Streptococcus pyogenes MGAS2096 4065087 YP_601051.1 CDS MGAS2096_Spy1455 NC_008023.1 1419649 1420248 R phage protein complement(1419649..1420248) Streptococcus pyogenes MGAS2096 4065088 YP_601052.1 CDS MGAS2096_Spy1456 NC_008023.1 1420260 1420619 R phage protein complement(1420260..1420619) Streptococcus pyogenes MGAS2096 4065089 YP_601053.1 CDS MGAS2096_Spy1457 NC_008023.1 1420623 1420967 R phage protein complement(1420623..1420967) Streptococcus pyogenes MGAS2096 4065090 YP_601054.1 CDS MGAS2096_Spy1458 NC_008023.1 1420964 1421242 R phage protein complement(1420964..1421242) Streptococcus pyogenes MGAS2096 4065091 YP_601055.1 CDS MGAS2096_Spy1459 NC_008023.1 1421253 1421609 R phage protein complement(1421253..1421609) Streptococcus pyogenes MGAS2096 4065092 YP_601056.1 CDS MGAS2096_Spy1460 NC_008023.1 1421621 1422508 R phage protein complement(1421621..1422508) Streptococcus pyogenes MGAS2096 4065093 YP_601057.1 CDS MGAS2096_Spy1461 NC_008023.1 1422521 1423090 R phage scaffold protein complement(1422521..1423090) Streptococcus pyogenes MGAS2096 4065094 YP_601058.1 CDS MGAS2096_Spy1462 NC_008023.1 1423246 1423512 R phage protein complement(1423246..1423512) Streptococcus pyogenes MGAS2096 4065095 YP_601059.1 CDS MGAS2096_Spy1463 NC_008023.1 1423515 1423703 R phage protein complement(1423515..1423703) Streptococcus pyogenes MGAS2096 4065096 YP_601060.1 CDS MGAS2096_Spy1464 NC_008023.1 1423734 1425182 R phage protein complement(1423734..1425182) Streptococcus pyogenes MGAS2096 4065381 YP_601061.1 CDS MGAS2096_Spy1465 NC_008023.1 1425139 1426671 R portal protein complement(1425139..1426671) Streptococcus pyogenes MGAS2096 4065382 YP_601062.1 CDS MGAS2096_Spy1466 NC_008023.1 1426687 1427973 R terminase large subunit complement(1426687..1427973) Streptococcus pyogenes MGAS2096 4065383 YP_601063.1 CDS MGAS2096_Spy1467 NC_008023.1 1427954 1428448 R phage terminase small subunit complement(1427954..1428448) Streptococcus pyogenes MGAS2096 4065384 YP_601064.1 CDS MGAS2096_Spy1468 NC_008023.1 1428496 1428912 R phage transcriptional activator complement(1428496..1428912) Streptococcus pyogenes MGAS2096 4065385 YP_601065.1 CDS MGAS2096_Spy1469 NC_008023.1 1428909 1429100 R phage protein complement(1428909..1429100) Streptococcus pyogenes MGAS2096 4065386 YP_601066.1 CDS MGAS2096_Spy1470 NC_008023.1 1429090 1429941 R adenine-specific methyltransferase complement(1429090..1429941) Streptococcus pyogenes MGAS2096 4065387 YP_601067.1 CDS MGAS2096_Spy1471 NC_008023.1 1429950 1430216 R phage protein complement(1429950..1430216) Streptococcus pyogenes MGAS2096 4065388 YP_601068.1 CDS MGAS2096_Spy1472 NC_008023.1 1430213 1430380 R phage protein complement(1430213..1430380) Streptococcus pyogenes MGAS2096 4065389 YP_601069.1 CDS MGAS2096_Spy1473 NC_008023.1 1430381 1431703 R phage-related DNA helicase complement(1430381..1431703) Streptococcus pyogenes MGAS2096 4065390 YP_601070.1 CDS MGAS2096_Spy1474 NC_008023.1 1431700 1431993 R hypothetical protein complement(1431700..1431993) Streptococcus pyogenes MGAS2096 4065391 YP_601071.1 CDS MGAS2096_Spy1475 NC_008023.1 1432362 1434746 R DNA primase complement(1432362..1434746) Streptococcus pyogenes MGAS2096 4065392 YP_601072.1 CDS MGAS2096_Spy1476 NC_008023.1 1434751 1436673 R phage-related DNA polymerase complement(1434751..1436673) Streptococcus pyogenes MGAS2096 4065393 YP_601073.1 CDS MGAS2096_Spy1477 NC_008023.1 1436716 1437273 R phage protein complement(1436716..1437273) Streptococcus pyogenes MGAS2096 4065394 YP_601074.1 CDS MGAS2096_Spy1478 NC_008023.1 1437284 1437682 R phage protein complement(1437284..1437682) Streptococcus pyogenes MGAS2096 4065395 YP_601075.1 CDS MGAS2096_Spy1479 NC_008023.1 1437686 1438840 R phage protein complement(1437686..1438840) Streptococcus pyogenes MGAS2096 4065396 YP_601076.1 CDS MGAS2096_Spy1480 NC_008023.1 1438840 1439139 R phage protein complement(1438840..1439139) Streptococcus pyogenes MGAS2096 4065397 YP_601077.1 CDS MGAS2096_Spy1481 NC_008023.1 1439227 1439430 R phage protein complement(1439227..1439430) Streptococcus pyogenes MGAS2096 4065398 YP_601078.1 CDS MGAS2096_Spy1482 NC_008023.1 1439577 1439963 R phage protein complement(1439577..1439963) Streptococcus pyogenes MGAS2096 4065399 YP_601079.1 CDS MGAS2096_Spy1483 NC_008023.1 1439960 1440175 R phage protein complement(1439960..1440175) Streptococcus pyogenes MGAS2096 4064596 YP_601080.1 CDS MGAS2096_Spy1484 NC_008023.1 1440156 1440353 R phage protein complement(1440156..1440353) Streptococcus pyogenes MGAS2096 4064597 YP_601081.1 CDS MGAS2096_Spy1485 NC_008023.1 1440323 1440598 R phage protein complement(1440323..1440598) Streptococcus pyogenes MGAS2096 4064598 YP_601082.1 CDS MGAS2096_Spy1486 NC_008023.1 1440660 1440875 R phage protein complement(1440660..1440875) Streptococcus pyogenes MGAS2096 4064599 YP_601083.1 CDS MGAS2096_Spy1487 NC_008023.1 1440908 1441336 D phage protein 1440908..1441336 Streptococcus pyogenes MGAS2096 4064600 YP_601084.1 CDS MGAS2096_Spy1488 NC_008023.1 1441317 1441472 R phage protein complement(1441317..1441472) Streptococcus pyogenes MGAS2096 4064601 YP_601085.1 CDS MGAS2096_Spy1489 NC_008023.1 1441747 1442148 D Cro/CI family phage transcriptional regulator 1441747..1442148 Streptococcus pyogenes MGAS2096 4064602 YP_601086.1 CDS MGAS2096_Spy1490 NC_008023.1 1442162 1442545 D phage protein 1442162..1442545 Streptococcus pyogenes MGAS2096 4064603 YP_601087.1 CDS MGAS2096_Spy1491 NC_008023.1 1442556 1443107 D phage protein 1442556..1443107 Streptococcus pyogenes MGAS2096 4064604 YP_601088.1 CDS int3 NC_008023.1 1443215 1444303 D DNA integration/recombination/inversion protein 1443215..1444303 Streptococcus pyogenes MGAS2096 4064605 YP_601089.1 CDS trmB NC_008023.1 1444501 1445136 R tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase complement(1444501..1445136) Streptococcus pyogenes MGAS2096 4064607 YP_601090.1 CDS MGAS2096_Spy1494 NC_008023.1 1445136 1445927 R phosphotransferase family protein complement(1445136..1445927) Streptococcus pyogenes MGAS2096 4064608 YP_601091.1 CDS MGAS2096_Spy1495 NC_008023.1 1445991 1447025 R protein ecsB complement(1445991..1447025) Streptococcus pyogenes MGAS2096 4064609 YP_601092.1 CDS MGAS2096_Spy1496 NC_008023.1 1447028 1447753 R ABC-type transporter ATP-binding protein ecsA complement(1447028..1447753) Streptococcus pyogenes MGAS2096 4064610 YP_601093.1 CDS hit NC_008023.1 1447825 1448244 D bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) 1447825..1448244 Streptococcus pyogenes MGAS2096 4064611 YP_601094.1 CDS MGAS2096_Spy1498 NC_008023.1 1448241 1448597 D hypothetical protein 1448241..1448597 Streptococcus pyogenes MGAS2096 4064612 YP_601095.1 CDS lytR NC_008023.1 1448708 1449988 R LytR family transcriptional regulator complement(1448708..1449988) Streptococcus pyogenes MGAS2096 4064613 YP_601096.1 CDS MGAS2096_Spy1500 NC_008023.1 1449997 1450521 R acetyltransferase complement(1449997..1450521) Streptococcus pyogenes MGAS2096 4064614 YP_601097.1 CDS MGAS2096_Spy1501 NC_008023.1 1450496 1450957 R ATP/GTP hydrolase complement(1450496..1450957) Streptococcus pyogenes MGAS2096 4065420 YP_601098.1 CDS MGAS2096_Spy1502 NC_008023.1 1451111 1452571 R guanine-hypoxanthine permease complement(1451111..1452571) Streptococcus pyogenes MGAS2096 4065421 YP_601099.1 CDS MGAS2096_Spy1503 NC_008023.1 1452835 1453134 D HAD superfamily; hydrolase 1452835..1453134 Streptococcus pyogenes MGAS2096 4065422 YP_601100.1 CDS MGAS2096_Spy1504 NC_008023.1 1453142 1453648 D HAD superfamily; hydrolase 1453142..1453648 Streptococcus pyogenes MGAS2096 4065423 YP_601101.1 CDS manL NC_008023.1 1454000 1454605 D PTS system mannose-specific transporter subunit IIAB 1454000..1454605 Streptococcus pyogenes MGAS2096 4065424 YP_601102.1 CDS MGAS2096_Spy1506 NC_008023.1 1454637 1454993 D PTS system mannose-specific transporter subunit IIAB 1454637..1454993 Streptococcus pyogenes MGAS2096 4065425 YP_601103.1 CDS manM NC_008023.1 1455082 1455891 D PTS system mannose-specific transporter subunit IIC 1455082..1455891 Streptococcus pyogenes MGAS2096 4065426 YP_601104.1 CDS manN NC_008023.1 1455908 1456819 D PTS system mannose-specific transporter subunit IID 1455908..1456819 Streptococcus pyogenes MGAS2096 4065427 YP_601105.1 CDS manO NC_008023.1 1456840 1457292 D putative cytoplasmic protein 1456840..1457292 Streptococcus pyogenes MGAS2096 4065428 YP_601106.1 CDS serS NC_008023.1 1457683 1458960 D catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1457683..1458960 Streptococcus pyogenes MGAS2096 4065429 YP_601107.1 CDS accD NC_008023.1 1459182 1459952 R catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; these proteins present a shorter N-terminus; acetyl-CoA carboxylase subunit alpha complement(1459182..1459952) Streptococcus pyogenes MGAS2096 4065430 YP_601108.1 CDS accA NC_008023.1 1459949 1460815 R catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta complement(1459949..1460815) Streptococcus pyogenes MGAS2096 4065431 YP_601109.2 CDS accC NC_008023.1 1460824 1462188 R an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit complement(1460824..1462188) Streptococcus pyogenes MGAS2096 4065432 YP_601110.1 CDS fabZ NC_008023.1 1462220 1462642 R in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase complement(1462220..1462642) Streptococcus pyogenes MGAS2096 4065433 YP_601111.1 CDS accB NC_008023.1 1462639 1462803 R biotin carboxyl carrier protein of acetyl-CoA carboxylase complement(1462639..1462803) Streptococcus pyogenes MGAS2096 4065434 YP_601112.1 CDS MGAS2096_Spy1516 NC_008023.1 1462922 1463137 R biotin carboxyl carrier protein of acetyl-CoA carboxylase complement(1462922..1463137) Streptococcus pyogenes MGAS2096 4065435 YP_601113.1 CDS fabF NC_008023.1 1463139 1464371 R FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II complement(1463139..1464371) Streptococcus pyogenes MGAS2096 4065436 YP_601114.1 CDS fabG NC_008023.1 1464386 1465120 R catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase complement(1464386..1465120) Streptococcus pyogenes MGAS2096 4065437 YP_601115.1 CDS fabD NC_008023.1 1465110 1466054 R acyl-carrier-protein S-malonyltransferase complement(1465110..1466054) Streptococcus pyogenes MGAS2096 4065438 YP_601116.1 CDS fabK NC_008023.1 1466073 1467044 R acyl-carrier protein; enoyl- reductase (NADH) complement(1466073..1467044) Streptococcus pyogenes MGAS2096 4065575 YP_601117.1 CDS acpP NC_008023.1 1467246 1467470 R carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein complement(1467246..1467470) Streptococcus pyogenes MGAS2096 4065576 YP_601118.1 CDS fabH NC_008023.1 1467531 1468505 R FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase complement(1467531..1468505) Streptococcus pyogenes MGAS2096 4065577 YP_601119.1 CDS MGAS2096_Spy1523 NC_008023.1 1468506 1468976 R MarR family transcriptional regulator complement(1468506..1468976) Streptococcus pyogenes MGAS2096 4065578 YP_601120.1 CDS phaB NC_008023.1 1469014 1469805 R Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase complement(1469014..1469805) Streptococcus pyogenes MGAS2096 4065579 YP_601121.1 CDS dnaJ NC_008023.1 1470027 1471217 R chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ complement(1470027..1471217) Streptococcus pyogenes MGAS2096 4065580 YP_601122.1 CDS dnaK NC_008023.1 1471444 1473270 R heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK complement(1471444..1473270) Streptococcus pyogenes MGAS2096 4065581 YP_601123.1 CDS grpE NC_008023.1 1473451 1474023 R with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE complement(1473451..1474023) Streptococcus pyogenes MGAS2096 4065582 YP_601124.1 CDS hrcA NC_008023.1 1474026 1475060 R Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor complement(1474026..1475060) Streptococcus pyogenes MGAS2096 4065583 YP_601125.1 CDS MGAS2096_Spy1529 NC_008023.1 1475195 1475764 R N-acetylmuramoyl-L-alanine amidase complement(1475195..1475764) Streptococcus pyogenes MGAS2096 4065584 YP_601126.1 CDS MGAS2096_Spy1530 NC_008023.1 1475761 1476504 R D-alanyl-D-alanine metallocarboxypeptidase complement(1475761..1476504) Streptococcus pyogenes MGAS2096 4065585 YP_601127.1 CDS MGAS2096_Spy1531 NC_008023.1 1476494 1477201 R phosphoglycerate mutase family protein complement(1476494..1477201) Streptococcus pyogenes MGAS2096 4065586 YP_601128.1 CDS MGAS2096_Spy1532 NC_008023.1 1477593 1477841 R hypothetical protein complement(1477593..1477841) Streptococcus pyogenes MGAS2096 4065587 YP_601129.1 CDS MGAS2096_Spy1533 NC_008023.1 1478051 1478266 R hypothetical protein complement(1478051..1478266) Streptococcus pyogenes MGAS2096 4065588 YP_601130.1 CDS gatB NC_008023.1 1478263 1479702 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B complement(1478263..1479702) Streptococcus pyogenes MGAS2096 4065589 YP_601131.1 CDS gatA NC_008023.1 1479702 1481168 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A complement(1479702..1481168) Streptococcus pyogenes MGAS2096 4065590 YP_601132.2 CDS gatC NC_008023.1 1481168 1481470 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C complement(1481168..1481470) Streptococcus pyogenes MGAS2096 4065591 YP_601133.1 CDS MGAS2096_Spy1537 NC_008023.1 1481703 1481951 R pyruvate,phosphate dikinase complement(1481703..1481951) Streptococcus pyogenes MGAS2096 4065592 YP_601134.1 CDS MGAS2096_Spy1538 NC_008023.1 1482466 1483023 R bifunctional; pyrazinamidase / nicotinamidase complement(1482466..1483023) Streptococcus pyogenes MGAS2096 4065593 YP_601135.1 CDS codY NC_008023.1 1483167 1484012 R CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; transcriptional repressor CodY complement(1483167..1484012) Streptococcus pyogenes MGAS2096 4065594 YP_601136.2 CDS MGAS2096_Spy1540 NC_008023.1 1484167 1485381 R broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT complement(1484167..1485381) Streptococcus pyogenes MGAS2096 4065732 YP_601137.1 CDS MGAS2096_Spy1541 NC_008023.1 1485522 1486064 D universal stress protein 1485522..1486064 Streptococcus pyogenes MGAS2096 4065733 YP_601138.1 CDS MGAS2096_Spy1542 NC_008023.1 1486187 1487575 R HAD superfamily; hydrolase complement(1486187..1487575) Streptococcus pyogenes MGAS2096 4065734 YP_601139.1 CDS asnB NC_008023.1 1487647 1488612 D L-asparaginase 1487647..1488612 Streptococcus pyogenes MGAS2096 4065735 YP_601140.1 CDS MGAS2096_Spy1544 NC_008023.1 1488961 1489665 R ABC transporter permease complement(1488961..1489665) Streptococcus pyogenes MGAS2096 4065736 YP_601141.1 CDS MGAS2096_Spy1545 NC_008023.1 1489678 1490580 R lantibiotic ABC transporter ATP-binding protein complement(1489678..1490580) Streptococcus pyogenes MGAS2096 4065737 YP_601142.1 CDS recG NC_008023.1 1490873 1492888 R catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG complement(1490873..1492888) Streptococcus pyogenes MGAS2096 4065738 YP_601143.1 CDS MGAS2096_Spy1547 NC_008023.1 1492981 1493181 D hypothetical protein 1492981..1493181 Streptococcus pyogenes MGAS2096 4065739 YP_601144.1 CDS MGAS2096_Spy1548 NC_008023.1 1493263 1494717 R cobalt transport ATP-binding protein cbiO complement(1493263..1494717) Streptococcus pyogenes MGAS2096 4065740 YP_601145.1 CDS MGAS2096_Spy1549 NC_008023.1 1494654 1495334 R cobalt transport protein cbiQ complement(1494654..1495334) Streptococcus pyogenes MGAS2096 4065741 YP_601146.1 CDS MGAS2096_Spy1550 NC_008023.1 1495331 1495924 R membrane-bound protein complement(1495331..1495924) Streptococcus pyogenes MGAS2096 4065742 YP_601147.1 CDS MGAS2096_Spy1551 NC_008023.1 1495921 1497624 R ABC transporter ATP-binding protein complement(1495921..1497624) Streptococcus pyogenes MGAS2096 4065743 YP_601148.1 CDS MGAS2096_Spy1552 NC_008023.1 1497584 1499347 R ABC transporter ATP-binding protein complement(1497584..1499347) Streptococcus pyogenes MGAS2096 4065744 YP_601149.1 CDS fhuC NC_008023.1 1499344 1500180 R ferrichrome ABC transporter ATP-binding protein complement(1499344..1500180) Streptococcus pyogenes MGAS2096 4065745 YP_601150.1 CDS MGAS2096_Spy1554 NC_008023.1 1500177 1501226 R ferrichrome transport system permease fhuB complement(1500177..1501226) Streptococcus pyogenes MGAS2096 4065746 YP_601151.1 CDS MGAS2096_Spy1555 NC_008023.1 1501201 1502112 R ferrichrome-binding protein complement(1501201..1502112) Streptococcus pyogenes MGAS2096 4065747 YP_601152.1 CDS shp NC_008023.1 1502082 1502945 R hypothetical protein complement(1502082..1502945) Streptococcus pyogenes MGAS2096 4065748 YP_601153.1 CDS MGAS2096_Spy1557 NC_008023.1 1503142 1506975 R iron ABC transporter permease complement(1503142..1506975) Streptococcus pyogenes MGAS2096 4065749 YP_601154.1 CDS isp2 NC_008023.1 1507459 1508988 R immunogenic secreted protein complement(1507459..1508988) Streptococcus pyogenes MGAS2096 4065750 YP_601155.1 CDS alr NC_008023.1 1509075 1510175 R converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase complement(1509075..1510175) Streptococcus pyogenes MGAS2096 4065361 YP_601156.1 CDS acpS NC_008023.1 1510172 1510528 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(1510172..1510528) Streptococcus pyogenes MGAS2096 4065362 YP_601157.1 CDS secA NC_008023.1 1510644 1513163 R functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA complement(1510644..1513163) Streptococcus pyogenes MGAS2096 4065363 YP_601158.1 CDS MGAS2096_Spy1562 NC_008023.1 1513328 1514470 R transposase complement(1513328..1514470) Streptococcus pyogenes MGAS2096 4065364 YP_601159.1 CDS pmi NC_008023.1 1514622 1515575 R mannose-6-phosphate isomerase complement(1514622..1515575) Streptococcus pyogenes MGAS2096 4065365 YP_601160.1 CDS scrK NC_008023.1 1515670 1516554 R fructokinase complement(1515670..1516554) Streptococcus pyogenes MGAS2096 4065366 YP_601161.1 CDS endoS NC_008023.1 1516818 1519859 R endo-beta-N-acetylglucosaminidase F2 complement(1516818..1519859) Streptococcus pyogenes MGAS2096 4065367 YP_601162.1 CDS MGAS2096_Spy1566 NC_008023.1 1519829 1519993 R hypothetical protein complement(1519829..1519993) Streptococcus pyogenes MGAS2096 4065368 YP_601163.1 CDS scrA NC_008023.1 1520036 1521733 R PTS system sucrose-specific transporter subunit IIABC complement(1520036..1521733) Streptococcus pyogenes MGAS2096 4065369 YP_601164.1 CDS scrB NC_008023.1 1522386 1523600 D sucrose-6-phosphate hydrolase 1522386..1523600 Streptococcus pyogenes MGAS2096 4065370 YP_601165.1 CDS scrR NC_008023.1 1523605 1524570 D sucrose operon repressor 1523605..1524570 Streptococcus pyogenes MGAS2096 4065371 YP_601166.1 CDS nusB NC_008023.1 1524711 1525181 R Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB complement(1524711..1525181) Streptococcus pyogenes MGAS2096 4065372 YP_601167.1 CDS MGAS2096_Spy1571 NC_008023.1 1525156 1525545 R Gls24 family general stress protein complement(1525156..1525545) Streptococcus pyogenes MGAS2096 4065373 YP_601168.1 CDS efp NC_008023.1 1525591 1526148 R Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P complement(1525591..1526148) Streptococcus pyogenes MGAS2096 4065374 YP_601169.1 CDS comEB NC_008023.1 1526244 1526750 R ComE operon protein 2 complement(1526244..1526750) Streptococcus pyogenes MGAS2096 4065375 YP_601170.1 CDS MGAS2096_Spy1574 NC_008023.1 1526740 1527711 R Xaa-Pro dipeptidase complement(1526740..1527711) Streptococcus pyogenes MGAS2096 4065376 YP_601171.1 CDS uvrA NC_008023.1 1527930 1530788 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A complement(1527930..1530788) Streptococcus pyogenes MGAS2096 4065377 YP_601172.1 CDS corA NC_008023.1 1530961 1531905 D magnesium/cobalt transporter CorA 1530961..1531905 Streptococcus pyogenes MGAS2096 4065378 YP_601173.1 CDS MGAS2096_Spy1577 NC_008023.1 1532037 1532693 D hypothetical protein 1532037..1532693 Streptococcus pyogenes MGAS2096 4065379 YP_601174.1 CDS rpsR NC_008023.1 1532826 1533065 R binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 complement(1532826..1533065) Streptococcus pyogenes MGAS2096 4065380 YP_601175.1 CDS ssb2 NC_008023.1 1533230 1533721 R binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein complement(1533230..1533721) Streptococcus pyogenes MGAS2096 4064694 YP_601176.1 CDS rpsF NC_008023.1 1533743 1534033 R binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 complement(1533743..1534033) Streptococcus pyogenes MGAS2096 4064695 YP_601177.1 CDS MGAS2096_Spy1581 NC_008023.1 1534206 1534499 R hypothetical protein complement(1534206..1534499) Streptococcus pyogenes MGAS2096 4064696 YP_601178.1 CDS mutY NC_008023.1 1534898 1535821 D A/G-specific adenine glycosylase 1534898..1535821 Streptococcus pyogenes MGAS2096 4064697 YP_601179.1 CDS MGAS2096_Spy1583 NC_008023.1 1535888 1536484 D transcriptional regulator 1535888..1536484 Streptococcus pyogenes MGAS2096 4064698 YP_601180.1 CDS trx NC_008023.1 1536536 1536892 R thioredoxin complement(1536536..1536892) Streptococcus pyogenes MGAS2096 4064699 YP_601181.1 CDS MGAS2096_Spy1585 NC_008023.1 1536931 1537431 R phosphatidylglycerophosphatase B complement(1536931..1537431) Streptococcus pyogenes MGAS2096 4064700 YP_601182.1 CDS mutS2 NC_008023.1 1537435 1539891 R DNA mismatch repair protein mutS complement(1537435..1539891) Streptococcus pyogenes MGAS2096 4064701 YP_601183.1 CDS MGAS2096_Spy1587 NC_008023.1 1539923 1540468 R CvpA family membrane protein complement(1539923..1540468) Streptococcus pyogenes MGAS2096 4064702 YP_601184.1 CDS MGAS2096_Spy1588 NC_008023.1 1540471 1540779 R putative cytoplasmic protein complement(1540471..1540779) Streptococcus pyogenes MGAS2096 4064703 YP_601185.1 CDS MGAS2096_Spy1589 NC_008023.1 1540936 1541838 D An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease HIII 1540936..1541838 Streptococcus pyogenes MGAS2096 4064704 YP_601186.1 CDS spi NC_008023.1 1541783 1542442 D Signal peptidase I 1541783..1542442 Streptococcus pyogenes MGAS2096 4064705 YP_601187.1 CDS recD NC_008023.1 1542500 1544953 D exodeoxyribonuclease V subunit alpha 1542500..1544953 Streptococcus pyogenes MGAS2096 4064706 YP_601188.1 CDS MGAS2096_Spy1592 NC_008023.1 1545044 1545535 D hypothetical protein 1545044..1545535 Streptococcus pyogenes MGAS2096 4064707 YP_601189.1 CDS dinP NC_008023.1 1545620 1546714 R involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV complement(1545620..1546714) Streptococcus pyogenes MGAS2096 4064708 YP_601190.1 CDS pfl NC_008023.1 1546896 1549250 D formate acetyltransferase 1546896..1549250 Streptococcus pyogenes MGAS2096 4064709 YP_601191.1 CDS MGAS2096_Spy1595 NC_008023.1 1549430 1550380 R Beta-lactamase family protein complement(1549430..1550380) Streptococcus pyogenes MGAS2096 4064710 YP_601192.1 CDS MGAS2096_Spy1596 NC_008023.1 1550365 1551117 R putative cytoplasmic protein complement(1550365..1551117) Streptococcus pyogenes MGAS2096 4064711 YP_601193.1 CDS MGAS2096_Spy1597 NC_008023.1 1551379 1552311 D hypothetical protein 1551379..1552311 Streptococcus pyogenes MGAS2096 4064712 YP_601194.1 CDS glpF2 NC_008023.1 1552647 1553594 R Aquaporin / glycerol uptake facilitator protein complement(1552647..1553594) Streptococcus pyogenes MGAS2096 4065964 YP_601195.1 CDS MGAS2096_Spy1599 NC_008023.1 1553665 1553811 R universal stress protein complement(1553665..1553811) Streptococcus pyogenes MGAS2096 4065965 YP_601196.1 CDS norA NC_008023.1 1553997 1555298 R major facilitator transporter complement(1553997..1555298) Streptococcus pyogenes MGAS2096 4065966 YP_601197.1 CDS srv NC_008023.1 1555299 1556018 D Crp family transcriptional regulator 1555299..1556018 Streptococcus pyogenes MGAS2096 4065967 YP_601198.1 CDS pepXP NC_008023.1 1556040 1558322 D catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue; x-prolyl-dipeptidyl aminopeptidase 1556040..1558322 Streptococcus pyogenes MGAS2096 4065968 YP_601199.1 CDS MGAS2096_Spy1603 NC_008023.1 1558402 1558623 R Cro/CI family transcriptional regulator complement(1558402..1558623) Streptococcus pyogenes MGAS2096 4065969 YP_601200.1 CDS MGAS2096_Spy1604 NC_008023.1 1558793 1559167 D transcriptional regulator 1558793..1559167 Streptococcus pyogenes MGAS2096 4065970 YP_601201.1 CDS MGAS2096_Spy1605 NC_008023.1 1559360 1559659 D hypothetical protein 1559360..1559659 Streptococcus pyogenes MGAS2096 4065971 YP_601202.1 CDS MGAS2096_Spy1606 NC_008023.1 1559843 1560460 R MerR family transcriptional regulator complement(1559843..1560460) Streptococcus pyogenes MGAS2096 4065972 YP_601203.1 CDS dnaQ NC_008023.1 1560606 1561232 R 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon complement(1560606..1561232) Streptococcus pyogenes MGAS2096 4065973 YP_601204.1 CDS MGAS2096_Spy1608 NC_008023.1 1561242 1561823 R putative cytoplasmic protein complement(1561242..1561823) Streptococcus pyogenes MGAS2096 4065974 YP_601205.1 CDS MGAS2096_Spy1609 NC_008023.1 1561977 1563146 D NAD(FAD)-utilizing dehydrogenases 1561977..1563146 Streptococcus pyogenes MGAS2096 4065975 YP_601206.1 CDS deoC NC_008023.1 1563241 1563912 R catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase complement(1563241..1563912) Streptococcus pyogenes MGAS2096 4065976 YP_601207.1 CDS nupC NC_008023.1 1563942 1565156 R nucleoside permease nupC complement(1563942..1565156) Streptococcus pyogenes MGAS2096 4065977 YP_601208.1 CDS udp NC_008023.1 1565165 1565944 R uridine phosphorylase complement(1565165..1565944) Streptococcus pyogenes MGAS2096 4065978 YP_601209.1 CDS MGAS2096_Spy1613 NC_008023.1 1566009 1566110 R hypothetical protein complement(1566009..1566110) Streptococcus pyogenes MGAS2096 4065979 YP_601210.1 CDS crgR NC_008023.1 1566184 1566942 D GntR family transcriptional regulator 1566184..1566942 Streptococcus pyogenes MGAS2096 4065980 YP_601211.1 CDS rpsN NC_008023.1 1567162 1567431 D located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 1567162..1567431 Streptococcus pyogenes MGAS2096 4065981 YP_601212.1 CDS MGAS2096_Spy1616 NC_008023.1 1567602 1567916 R O-sialoglycoprotein endopeptidase complement(1567602..1567916) Streptococcus pyogenes MGAS2096 4065982 YP_601213.1 CDS MGAS2096_Spy1617 NC_008023.1 1567829 1568629 R O-sialoglycoprotein endopeptidase complement(1567829..1568629) Streptococcus pyogenes MGAS2096 4065983 YP_601214.1 CDS MGAS2096_Spy1618 NC_008023.1 1568619 1569074 R ribosomal-protein-S18-alanine acetyltransferase complement(1568619..1569074) Streptococcus pyogenes MGAS2096 4066176 YP_601215.1 CDS MGAS2096_Spy1619 NC_008023.1 1569046 1569777 R M22 family non-proteolytic peptidase complement(1569046..1569777) Streptococcus pyogenes MGAS2096 4066177 YP_601216.1 CDS MGAS2096_Spy1620 NC_008023.1 1570027 1570257 D hypothetical protein 1570027..1570257 Streptococcus pyogenes MGAS2096 4066178 YP_601217.1 CDS MGAS2096_Spy1621 NC_008023.1 1570259 1571941 D Zn-dependent hydrolase 1570259..1571941 Streptococcus pyogenes MGAS2096 4066179 YP_601218.1 CDS glnA NC_008023.1 1572169 1573515 R glutamine synthetase complement(1572169..1573515) Streptococcus pyogenes MGAS2096 4066180 YP_601219.1 CDS MGAS2096_Spy1623 NC_008023.1 1573553 1573924 R MerR family transcriptional regulator complement(1573553..1573924) Streptococcus pyogenes MGAS2096 4066181 YP_601220.1 CDS MGAS2096_Spy1624 NC_008023.1 1573991 1574542 R hypothetical protein complement(1573991..1574542) Streptococcus pyogenes MGAS2096 4066182 YP_601221.1 CDS pgk NC_008023.1 1574805 1576001 R Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase complement(1574805..1576001) Streptococcus pyogenes MGAS2096 4066183 YP_601222.1 CDS lppC NC_008023.1 1576194 1577048 R acid phosphatase complement(1576194..1577048) Streptococcus pyogenes MGAS2096 4066184 YP_601223.1 CDS MGAS2096_Spy1627 NC_008023.1 1577277 1578167 R membrane protease family protein complement(1577277..1578167) Streptococcus pyogenes MGAS2096 4066185 YP_601224.1 CDS MGAS2096_Spy1628 NC_008023.1 1578404 1580068 R dihydroxyacetone kinase family protein complement(1578404..1580068) Streptococcus pyogenes MGAS2096 4066186 YP_601225.1 CDS asp NC_008023.1 1580068 1580433 R Gls24 family general stress protein complement(1580068..1580433) Streptococcus pyogenes MGAS2096 4066187 YP_601226.1 CDS rpmB NC_008023.1 1580585 1580773 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(1580585..1580773) Streptococcus pyogenes MGAS2096 4066188 YP_601227.1 CDS fba NC_008023.1 1581155 1582036 R catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase complement(1581155..1582036) Streptococcus pyogenes MGAS2096 4066189 YP_601228.1 CDS MGAS2096_Spy1632 NC_008023.1 1582382 1583308 R Alpha/beta hydrolase complement(1582382..1583308) Streptococcus pyogenes MGAS2096 4066191 YP_601229.1 CDS pyrG NC_008023.1 1583476 1585080 R CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase complement(1583476..1585080) Streptococcus pyogenes MGAS2096 4066192 YP_601230.1 CDS rpoE NC_008023.1 1585337 1585945 R participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; DNA-directed RNA polymerase subunit delta complement(1585337..1585945) Streptococcus pyogenes MGAS2096 4066193 YP_601231.1 CDS MGAS2096_Spy1635 NC_008023.1 1586124 1586702 R trigger factor, PPIase complement(1586124..1586702) Streptococcus pyogenes MGAS2096 4064791 YP_601232.1 CDS ropA NC_008023.1 1586699 1587493 R trigger factor, PPIase complement(1586699..1587493) Streptococcus pyogenes MGAS2096 4064792 YP_601233.1 CDS MGAS2096_Spy1637 NC_008023.1 1587727 1588572 D mechanosensitive ion channel 1587727..1588572 Streptococcus pyogenes MGAS2096 4064793 YP_601234.1 CDS MGAS2096_Spy1638 NC_008023.1 1588637 1589197 R hypothetical protein complement(1588637..1589197) Streptococcus pyogenes MGAS2096 4064794 YP_601235.1 CDS MGAS2096_Spy1639 NC_008023.1 1589211 1589681 R hypothetical protein complement(1589211..1589681) Streptococcus pyogenes MGAS2096 4064795 YP_601236.1 CDS thiD NC_008023.1 1589671 1590435 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(1589671..1590435) Streptococcus pyogenes MGAS2096 4064796 YP_601237.1 CDS truA NC_008023.1 1590425 1591174 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(1590425..1591174) Streptococcus pyogenes MGAS2096 4064797 YP_601238.1 CDS MGAS2096_Spy1642 NC_008023.1 1591360 1591767 R ATP-dependent endopeptidase Clp proteolytic subunit clpP complement(1591360..1591767) Streptococcus pyogenes MGAS2096 4064798 YP_601239.1 CDS MGAS2096_Spy1643 NC_008023.1 1597332 1597466 D hypothetical protein 1597332..1597466 Streptococcus pyogenes MGAS2096 4064615 YP_601240.1 CDS MGAS2096_Spy1644 NC_008023.1 1597628 1598770 R glycerate kinase complement(1597628..1598770) Streptococcus pyogenes MGAS2096 4064616 YP_601241.1 CDS hsdR NC_008023.1 1599051 1602029 D Type I restriction-modification system restriction subunit 1599051..1602029 Streptococcus pyogenes MGAS2096 4064617 YP_601242.1 CDS hsdS NC_008023.1 1602042 1603241 D type I restriction-modification system specificity subunit 1602042..1603241 Streptococcus pyogenes MGAS2096 4064618 YP_601243.1 CDS hsdM NC_008023.1 1603254 1604834 D Type I restriction-modification system methylation subunit 1603254..1604834 Streptococcus pyogenes MGAS2096 4064619 YP_601244.1 CDS MGAS2096_Spy1649 NC_008023.1 1605044 1605244 R hypothetical protein complement(1605044..1605244) Streptococcus pyogenes MGAS2096 4064620 YP_601245.1 CDS MGAS2096_Spy1648 NC_008023.1 1605210 1605329 D hypothetical protein 1605210..1605329 Streptococcus pyogenes MGAS2096 4064621 YP_601246.1 CDS salR NC_008023.1 1605386 1605991 R transcriptional regulatory protein degU complement(1605386..1605991) Streptococcus pyogenes MGAS2096 4064622 YP_601247.1 CDS MGAS2096_Spy1651 NC_008023.1 1605972 1607534 R sensory transduction protein kinase complement(1605972..1607534) Streptococcus pyogenes MGAS2096 4064623 YP_601248.1 CDS salY NC_008023.1 1607574 1609481 R ABC transporter permease complement(1607574..1609481) Streptococcus pyogenes MGAS2096 4064624 YP_601249.1 CDS MGAS2096_Spy1653 NC_008023.1 1609483 1610220 R ABC transporter ATP-binding protein complement(1609483..1610220) Streptococcus pyogenes MGAS2096 4064625 YP_601250.1 CDS salX NC_008023.1 1610217 1610681 R lantibiotic ABC transporter ATP-binding protein complement(1610217..1610681) Streptococcus pyogenes MGAS2096 4064626 YP_601251.1 CDS salB NC_008023.1 1610752 1612377 R lantibiotic biosynthesis; Serine (threonine) dehydratase complement(1610752..1612377) Streptococcus pyogenes MGAS2096 4064627 YP_601252.1 CDS salA NC_008023.1 1612459 1612614 R lantibiotic salivaricin A complement(1612459..1612614) Streptococcus pyogenes MGAS2096 4064628 YP_601253.1 CDS lacG NC_008023.1 1613117 1614523 R catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase complement(1613117..1614523) Streptococcus pyogenes MGAS2096 4064629 YP_601254.1 CDS lacE NC_008023.1 1614596 1616293 R PTS system lactose-specific transporter subunit IIBC complement(1614596..1616293) Streptococcus pyogenes MGAS2096 4064630 YP_601255.1 CDS lacF NC_008023.1 1616293 1616610 R PTS system lactose-specific transporter subunit IIA complement(1616293..1616610) Streptococcus pyogenes MGAS2096 4064631 YP_601256.1 CDS lacD2 NC_008023.1 1616634 1617617 R catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; tagatose 1,6-diphosphate aldolase complement(1616634..1617617) Streptococcus pyogenes MGAS2096 4064632 YP_601257.1 CDS lacC2 NC_008023.1 1617621 1618550 R catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP; tagatose-6-phosphate kinase complement(1617621..1618550) Streptococcus pyogenes MGAS2096 4064633 YP_601258.1 CDS lacB2 NC_008023.1 1618596 1619111 R catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; galactose-6-phosphate isomerase subunit LacB complement(1618596..1619111) Streptococcus pyogenes MGAS2096 4065283 YP_601259.1 CDS lacA2 NC_008023.1 1619146 1619574 R catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization; galactose-6-phosphate isomerase subunit LacA complement(1619146..1619574) Streptococcus pyogenes MGAS2096 4065284 YP_601260.1 CDS lacR2 NC_008023.1 1620020 1620793 D lactose phosphotransferase system repressor 1620020..1620793 Streptococcus pyogenes MGAS2096 4065285 YP_601261.1 CDS MGAS2096_Spy1665 NC_008023.1 1621443 1621730 D DNA-damage-inducible protein J 1621443..1621730 Streptococcus pyogenes MGAS2096 4065286 YP_601262.1 CDS MGAS2096_Spy1666 NC_008023.1 1621720 1622055 D putative cytoplasmic protein 1621720..1622055 Streptococcus pyogenes MGAS2096 4065287 YP_601263.1 CDS MGAS2096_Spy1667 NC_008023.1 1622207 1622677 D DNA integration/recombination/inversion protein 1622207..1622677 Streptococcus pyogenes MGAS2096 4065288 YP_601264.1 CDS MGAS2096_Spy1668 NC_008023.1 1623038 1623187 D DNA integration/recombination/inversion protein 1623038..1623187 Streptococcus pyogenes MGAS2096 4065289 YP_601265.1 CDS rpsI NC_008023.1 1623307 1623699 R forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 complement(1623307..1623699) Streptococcus pyogenes MGAS2096 4065290 YP_601266.2 CDS rplM NC_008023.1 1623720 1624166 R in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 complement(1623720..1624166) Streptococcus pyogenes MGAS2096 4065291 YP_601267.1 CDS MGAS2096_Spy1671 NC_008023.1 1624384 1624590 R Cro/CI family transcriptional regulator complement(1624384..1624590) Streptococcus pyogenes MGAS2096 4065292 YP_601268.1 CDS MGAS2096_Spy1672 NC_008023.1 1624587 1625126 R hypothetical protein complement(1624587..1625126) Streptococcus pyogenes MGAS2096 4065293 YP_601269.1 CDS MGAS2096_Spy1673 NC_008023.1 1625229 1626089 R DegV family fatty acid-binding protein complement(1625229..1626089) Streptococcus pyogenes MGAS2096 4065294 YP_601270.1 CDS MGAS2096_Spy1674 NC_008023.1 1626186 1626704 R putative cytoplasmic protein complement(1626186..1626704) Streptococcus pyogenes MGAS2096 4065295 YP_601271.1 CDS MGAS2096_Spy1675 NC_008023.1 1626708 1627481 R 23S rRNA Gm2251-methyltransferase complement(1626708..1627481) Streptococcus pyogenes MGAS2096 4065296 YP_601272.1 CDS MGAS2096_Spy1676 NC_008023.1 1627501 1628298 R hypothetical protein complement(1627501..1628298) Streptococcus pyogenes MGAS2096 4065297 YP_601273.1 CDS MGAS2096_Spy1677 NC_008023.1 1628494 1628907 R hypothetical protein complement(1628494..1628907) Streptococcus pyogenes MGAS2096 4065298 YP_601274.1 CDS cysS NC_008023.1 1628900 1630243 R catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase complement(1628900..1630243) Streptococcus pyogenes MGAS2096 4065299 YP_601275.1 CDS MGAS2096_Spy1679 NC_008023.1 1630271 1630501 R hypothetical protein complement(1630271..1630501) Streptococcus pyogenes MGAS2096 4065300 YP_601276.1 CDS MGAS2096_Spy1680 NC_008023.1 1630514 1630786 R putative cytoplasmic protein complement(1630514..1630786) Streptococcus pyogenes MGAS2096 4065301 YP_601277.1 CDS cysE NC_008023.1 1630980 1631561 R Serine acetyltransferase complement(1630980..1631561) Streptococcus pyogenes MGAS2096 4065302 YP_601278.1 CDS MGAS2096_Spy1682 NC_008023.1 1631570 1632322 R hypothetical protein complement(1631570..1632322) Streptococcus pyogenes MGAS2096 4065039 YP_601279.1 CDS MGAS2096_Spy1683 NC_008023.1 1632315 1634420 R polynucleotide phosphorylase/polyadenylase complement(1632315..1634420) Streptococcus pyogenes MGAS2096 4065040 YP_601280.1 CDS MGAS2096_Spy1684 NC_008023.1 1634729 1635460 R similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity; putative translaldolase complement(1634729..1635460) Streptococcus pyogenes MGAS2096 4065041 YP_601281.1 CDS ulaA NC_008023.1 1635470 1636849 R membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC complement(1635470..1636849) Streptococcus pyogenes MGAS2096 4065042 YP_601282.1 CDS MGAS2096_Spy1686 NC_008023.1 1636876 1637181 R PTS system transporter subunit IIB complement(1636876..1637181) Streptococcus pyogenes MGAS2096 4065043 YP_601283.1 CDS MGAS2096_Spy1687 NC_008023.1 1637153 1639315 R BigG family transcription antiterminator / PTS system, mannitol (Cryptic)-specific IIA component complement(1637153..1639315) Streptococcus pyogenes MGAS2096 4065044 YP_601284.1 CDS MGAS2096_Spy1688 NC_008023.1 1639438 1639581 R hypothetical protein complement(1639438..1639581) Streptococcus pyogenes MGAS2096 4065045 YP_601285.1 CDS rpsO NC_008023.1 1639565 1639834 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(1639565..1639834) Streptococcus pyogenes MGAS2096 4065046 YP_601286.1 CDS MGAS2096_Spy1690 NC_008023.1 1640010 1640210 R hypothetical protein complement(1640010..1640210) Streptococcus pyogenes MGAS2096 4065047 YP_601287.1 CDS MGAS2096_Spy1691 NC_008023.1 1640336 1640593 D putative transcriptional regulator 1640336..1640593 Streptococcus pyogenes MGAS2096 4065048 YP_601288.1 CDS def NC_008023.1 1640720 1641334 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1640720..1641334 Streptococcus pyogenes MGAS2096 4065049 YP_601289.1 CDS MGAS2096_Spy1693 NC_008023.1 1641367 1641909 R NADPH-dependent FMN reductase family protein complement(1641367..1641909) Streptococcus pyogenes MGAS2096 4065050 YP_601290.1 CDS MGAS2096_Spy1694 NC_008023.1 1642041 1642499 R MarR family transcriptional regulator complement(1642041..1642499) Streptococcus pyogenes MGAS2096 4065051 YP_601291.1 CDS polC NC_008023.1 1642579 1646976 R catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity; DNA polymerase III PolC complement(1642579..1646976) Streptococcus pyogenes MGAS2096 4065052 YP_601292.1 CDS proS NC_008023.1 1647230 1649086 R catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase complement(1647230..1649086) Streptococcus pyogenes MGAS2096 4065053 YP_601293.1 CDS MGAS2096_Spy1697 NC_008023.1 1649284 1650543 R M50 family membrane endopeptidase complement(1649284..1650543) Streptococcus pyogenes MGAS2096 4065054 YP_601294.1 CDS cdsA NC_008023.1 1650616 1651410 R phosphatidate cytidylyltransferase complement(1650616..1651410) Streptococcus pyogenes MGAS2096 4065055 YP_601295.1 CDS uppS NC_008023.1 1651423 1652172 R catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase complement(1651423..1652172) Streptococcus pyogenes MGAS2096 4065056 YP_601296.1 CDS yajC NC_008023.1 1652391 1652786 R member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC complement(1652391..1652786) Streptococcus pyogenes MGAS2096 4065057 YP_601297.1 CDS MGAS2096_Spy1701 NC_008023.1 1652872 1653246 R thioredoxin complement(1652872..1653246) Streptococcus pyogenes MGAS2096 4066117 YP_601298.1 CDS pulA NC_008023.1 1653361 1656885 R pullulanase complement(1653361..1656885) Streptococcus pyogenes MGAS2096 4066118 YP_601299.1 CDS MGAS2096_Spy1702 NC_008023.1 1656842 1657072 D hypothetical protein 1656842..1657072 Streptococcus pyogenes MGAS2096 4066119 YP_601300.1 CDS dexB NC_008023.1 1657056 1658690 R glucan 1,6-alpha-glucosidase complement(1657056..1658690) Streptococcus pyogenes MGAS2096 4066120 YP_601301.1 CDS msmK NC_008023.1 1658798 1659931 R sugar ABC transporter ATP-binding protein complement(1658798..1659931) Streptococcus pyogenes MGAS2096 4066121 YP_601302.1 CDS lrp NC_008023.1 1660229 1661119 R hypothetical protein complement(1660229..1661119) Streptococcus pyogenes MGAS2096 4066122 YP_601303.1 CDS ska NC_008023.1 1661418 1662740 D streptokinase 1661418..1662740 Streptococcus pyogenes MGAS2096 4066123 YP_601304.1 CDS MGAS2096_Spy1708 NC_008023.1 1662989 1663282 R hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase complement(1662989..1663282) Streptococcus pyogenes MGAS2096 4066124 YP_601305.1 CDS relA NC_008023.1 1663297 1665528 R bifunctional; GTP pyrophosphokinase / guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase complement(1663297..1665528) Streptococcus pyogenes MGAS2096 4066125 YP_601306.1 CDS sclA NC_008023.1 1665768 1667045 R collagen-like surface protein complement(1665768..1667045) Streptococcus pyogenes MGAS2096 4066126 YP_601307.1 CDS MGAS2096_Spy1711 NC_008023.1 1667427 1667753 D NrdI protein 1667427..1667753 Streptococcus pyogenes MGAS2096 4066127 YP_601308.1 CDS MGAS2096_Spy1712 NC_008023.1 1667699 1667887 D NrdI protein 1667699..1667887 Streptococcus pyogenes MGAS2096 4066128 YP_601309.1 CDS MGAS2096_Spy1713 NC_008023.1 1668282 1669121 R endonuclease/exonuclease/phosphatase family protein complement(1668282..1669121) Streptococcus pyogenes MGAS2096 4066129 YP_601310.1 CDS MGAS2096_Spy1714 NC_008023.1 1669183 1671369 R PTS system glucose-specific transporter subunit IIABC complement(1669183..1671369) Streptococcus pyogenes MGAS2096 4066130 YP_601311.1 CDS MGAS2096_Spy1715 NC_008023.1 1671725 1672474 R in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE complement(1671725..1672474) Streptococcus pyogenes MGAS2096 4066131 YP_601312.1 CDS prmA NC_008023.1 1672474 1673427 R methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase complement(1672474..1673427) Streptococcus pyogenes MGAS2096 4066132 YP_601313.1 CDS MGAS2096_Spy1717 NC_008023.1 1673498 1673968 R hypothetical protein complement(1673498..1673968) Streptococcus pyogenes MGAS2096 4066133 YP_601314.1 CDS MGAS2096_Spy1718 NC_008023.1 1674033 1674233 R RhuM complement(1674033..1674233) Streptococcus pyogenes MGAS2096 4066134 YP_601315.1 CDS MGAS2096_Spy1719 NC_008023.1 1674363 1674560 D ArpU family phage encoded transcriptional regulator 1674363..1674560 Streptococcus pyogenes MGAS2096 4066135 YP_601316.1 CDS MGAS2096_Spy1720 NC_008023.1 1674662 1675525 D transposase 1674662..1675525 Streptococcus pyogenes MGAS2096 4066136 YP_601317.1 CDS MGAS2096_Spy1721 NC_008023.1 1675512 1675667 D hypothetical protein 1675512..1675667 Streptococcus pyogenes MGAS2096 4065907 YP_601318.1 CDS MGAS2096_Spy1722 NC_008023.1 1675669 1676010 R hypothetical protein complement(1675669..1676010) Streptococcus pyogenes MGAS2096 4065908 YP_601319.1 CDS MGAS2096_Spy1723 NC_008023.1 1676503 1676694 D hypothetical protein 1676503..1676694 Streptococcus pyogenes MGAS2096 4065909 YP_601320.1 CDS MGAS2096_Spy1724 NC_008023.1 1676801 1678564 D bifunctional; Para-aminobenzoate synthetase component I / 4-amino-4-deoxychorismate lyase 1676801..1678564 Streptococcus pyogenes MGAS2096 4065910 YP_601321.1 CDS trpG NC_008023.1 1678597 1679163 D TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 1678597..1679163 Streptococcus pyogenes MGAS2096 4065911 YP_601322.1 CDS MGAS2096_Spy1726 NC_008023.1 1679196 1680464 D recombination factor protein RarA 1679196..1680464 Streptococcus pyogenes MGAS2096 4065912 YP_601323.1 CDS MGAS2096_Spy1727 NC_008023.1 1680921 1681403 D acetyltransferase 1680921..1681403 Streptococcus pyogenes MGAS2096 4065914 YP_601324.1 CDS flaR NC_008023.1 1681458 1681928 D topology modulation protein 1681458..1681928 Streptococcus pyogenes MGAS2096 4065915 YP_601325.1 CDS MGAS2096_Spy1730 NC_008023.1 1682092 1682256 R hypothetical protein complement(1682092..1682256) Streptococcus pyogenes MGAS2096 4065916 YP_601326.1 CDS smeZ NC_008023.1 1682213 1682914 D enterotoxin 1682213..1682914 Streptococcus pyogenes MGAS2096 4065917 YP_601327.1 CDS MGAS2096_Spy1731 NC_008023.1 1683241 1683465 R putative cytoplasmic protein complement(1683241..1683465) Streptococcus pyogenes MGAS2096 4065918 YP_601328.1 CDS dppA NC_008023.1 1683638 1685272 D dipeptide-binding protein 1683638..1685272 Streptococcus pyogenes MGAS2096 4065919 YP_601329.1 CDS dppB NC_008023.1 1685385 1686362 D peptide ABC transporter permease 1685385..1686362 Streptococcus pyogenes MGAS2096 4065920 YP_601330.1 CDS dppC NC_008023.1 1686359 1687180 D peptide ABC transporter permease 1686359..1687180 Streptococcus pyogenes MGAS2096 4065921 YP_601331.1 CDS dppD NC_008023.1 1687192 1687995 D peptide ABC transporter ATP-binding protein 1687192..1687995 Streptococcus pyogenes MGAS2096 4065922 YP_601332.1 CDS dppE NC_008023.1 1687979 1688605 D peptide ABC transporter ATP-binding protein 1687979..1688605 Streptococcus pyogenes MGAS2096 4065923 YP_601333.1 CDS MGAS2096_Spy1737 NC_008023.1 1688688 1688888 R hypothetical protein complement(1688688..1688888) Streptococcus pyogenes MGAS2096 4065924 YP_601334.1 CDS MGAS2096_Spy1738 NC_008023.1 1689057 1691399 R histidine triad protein complement(1689057..1691399) Streptococcus pyogenes MGAS2096 4064557 YP_601335.1 CDS MGAS2096_Spy1739 NC_008023.1 1691338 1691526 R putative cytoplasmic protein complement(1691338..1691526) Streptococcus pyogenes MGAS2096 4064558 YP_601336.1 CDS lmb NC_008023.1 1691539 1692459 R laminin-binding surface protein complement(1691539..1692459) Streptococcus pyogenes MGAS2096 4064559 YP_601337.1 CDS MGAS2096_Spy1741 NC_008023.1 1692537 1692653 R hypothetical protein complement(1692537..1692653) Streptococcus pyogenes MGAS2096 4064560 YP_601338.1 CDS MGAS2096_Spy1742 NC_008023.1 1692637 1693779 R transposase complement(1692637..1693779) Streptococcus pyogenes MGAS2096 4064561 YP_601339.1 CDS MGAS2096_Spy1743 NC_008023.1 1693824 1693976 R hypothetical protein complement(1693824..1693976) Streptococcus pyogenes MGAS2096 4064562 YP_601340.1 CDS scpA NC_008023.1 1694021 1697524 R C5A peptidase complement(1694021..1697524) Streptococcus pyogenes MGAS2096 4064563 YP_601341.1 CDS MGAS2096_Spy1745 NC_008023.1 1697958 1698617 D transposase 1697958..1698617 Streptococcus pyogenes MGAS2096 4064564 YP_601342.1 CDS MGAS2096_Spy1746 NC_008023.1 1698595 1699401 D transposase 1698595..1699401 Streptococcus pyogenes MGAS2096 4064565 YP_601343.1 CDS sic1-01 NC_008023.1 1699649 1700593 R complement inhibitor protein complement(1699649..1700593) Streptococcus pyogenes MGAS2096 4064566 YP_601344.1 CDS mga NC_008023.1 1700783 1704286 R transcriptional regulator complement(1700783..1704286) Streptococcus pyogenes MGAS2096 4064567 YP_601345.1 CDS MGAS2096_Spy1749 NC_008023.1 1704671 1704856 D hypothetical protein 1704671..1704856 Streptococcus pyogenes MGAS2096 4064568 YP_601346.1 CDS MGAS2096_Spy1750 NC_008023.1 1704962 1705213 R immunogenic protein complement(1704962..1705213) Streptococcus pyogenes MGAS2096 4064569 YP_601347.1 CDS isp NC_008023.1 1705291 1706919 R immunogenic secreted protein complement(1705291..1706919) Streptococcus pyogenes MGAS2096 4064570 YP_601348.1 CDS ihk NC_008023.1 1707021 1708409 R two-component system histidine kinase complement(1707021..1708409) Streptococcus pyogenes MGAS2096 4064571 YP_601349.1 CDS irr NC_008023.1 1708406 1709059 R two-component response regulator complement(1708406..1709059) Streptococcus pyogenes MGAS2096 4064572 YP_601350.1 CDS MGAS2096_Spy1754 NC_008023.1 1709153 1710370 R ABC transporter permease complement(1709153..1710370) Streptococcus pyogenes MGAS2096 4064573 YP_601351.1 CDS MGAS2096_Spy1755 NC_008023.1 1710383 1711057 R ABC transporter ATP-binding protein complement(1710383..1711057) Streptococcus pyogenes MGAS2096 4064574 YP_601352.1 CDS MGAS2096_Spy1756 NC_008023.1 1711044 1712312 R periplasmic protein of efflux system complement(1711044..1712312) Streptococcus pyogenes MGAS2096 4064575 YP_601353.1 CDS MGAS2096_Spy1758 NC_008023.1 1712736 1712906 R hypothetical protein complement(1712736..1712906) Streptococcus pyogenes MGAS2096 4064576 YP_601354.1 CDS MGAS2096_Spy1757 NC_008023.1 1712875 1713183 D hypothetical protein 1712875..1713183 Streptococcus pyogenes MGAS2096 4064752 YP_601355.1 CDS MGAS2096_Spy1759 NC_008023.1 1713164 1713460 R hypothetical protein complement(1713164..1713460) Streptococcus pyogenes MGAS2096 4064753 YP_601356.1 CDS MGAS2096_Spy1760 NC_008023.1 1713602 1715569 R fibronectin-binding protein complement(1713602..1715569) Streptococcus pyogenes MGAS2096 4064754 YP_601357.1 CDS MGAS2096_Spy1761 NC_008023.1 1715749 1716555 R fibronectin-binding protein complement(1715749..1716555) Streptococcus pyogenes MGAS2096 4064755 YP_601358.1 CDS MGAS2096_Spy1762 NC_008023.1 1716567 1718807 R fibronectin-binding protein complement(1716567..1718807) Streptococcus pyogenes MGAS2096 4064756 YP_601359.1 CDS MGAS2096_Spy1763 NC_008023.1 1719230 1719466 D putative cytoplasmic protein 1719230..1719466 Streptococcus pyogenes MGAS2096 4064757 YP_601360.1 CDS MGAS2096_Spy1764 NC_008023.1 1719737 1720690 R cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein; foldase PrsA complement(1719737..1720690) Streptococcus pyogenes MGAS2096 4064758 YP_601361.1 CDS MGAS2096_Spy1765 NC_008023.1 1720722 1721039 R hypothetical protein complement(1720722..1721039) Streptococcus pyogenes MGAS2096 4064759 YP_601362.1 CDS MGAS2096_Spy1766 NC_008023.1 1721146 1721451 R streptopain complement(1721146..1721451) Streptococcus pyogenes MGAS2096 4064760 YP_601363.1 CDS speB NC_008023.1 1721453 1722649 R streptopain complement(1721453..1722649) Streptococcus pyogenes MGAS2096 4064761 YP_601364.1 CDS MGAS2096_Spy1768 NC_008023.1 1722921 1723091 R hypothetical protein complement(1722921..1723091) Streptococcus pyogenes MGAS2096 4064762 YP_601365.1 CDS MGAS2096_Spy1769 NC_008023.1 1723175 1723306 D hypothetical protein 1723175..1723306 Streptococcus pyogenes MGAS2096 4064763 YP_601366.1 CDS rgg NC_008023.1 1723590 1724432 D transcriptional regulator 1723590..1724432 Streptococcus pyogenes MGAS2096 4064764 YP_601367.1 CDS MGAS2096_Spy1771 NC_008023.1 1724673 1724897 R streptodornase complement(1724673..1724897) Streptococcus pyogenes MGAS2096 4064765 YP_601368.1 CDS spd NC_008023.1 1724921 1725517 R streptodornase complement(1724921..1725517) Streptococcus pyogenes MGAS2096 4064766 YP_601369.1 CDS MGAS2096_Spy1773 NC_008023.1 1725571 1725699 D hypothetical protein 1725571..1725699 Streptococcus pyogenes MGAS2096 4064767 YP_601370.1 CDS MGAS2096_Spy1774 NC_008023.1 1725851 1726360 D low temperature requirement C protein 1725851..1726360 Streptococcus pyogenes MGAS2096 4064768 YP_601371.1 CDS gldA NC_008023.1 1726442 1727530 R forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase complement(1726442..1727530) Streptococcus pyogenes MGAS2096 4064769 YP_601372.1 CDS mipB NC_008023.1 1727587 1728255 R similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase complement(1727587..1728255) Streptococcus pyogenes MGAS2096 4064770 YP_601373.1 CDS pflD NC_008023.1 1728268 1730685 R formate acetyltransferase complement(1728268..1730685) Streptococcus pyogenes MGAS2096 4065136 YP_601374.1 CDS MGAS2096_Spy1778 NC_008023.1 1730896 1732200 R PTS system cellobiose-specific transporter subunit IIC complement(1730896..1732200) Streptococcus pyogenes MGAS2096 4065137 YP_601375.1 CDS MGAS2096_Spy1779 NC_008023.1 1732210 1732518 R PTS system cellobiose-specific transporter subunit IIB complement(1732210..1732518) Streptococcus pyogenes MGAS2096 4065138 YP_601376.1 CDS MGAS2096_Spy1780 NC_008023.1 1732546 1732866 R PTS system cellobiose-specific transporter subunit IIA complement(1732546..1732866) Streptococcus pyogenes MGAS2096 4065139 YP_601377.1 CDS MGAS2096_Spy1781 NC_008023.1 1733153 1734133 R sorbitol operon regulator complement(1733153..1734133) Streptococcus pyogenes MGAS2096 4065140 YP_601378.1 CDS MGAS2096_Spy1782 NC_008023.1 1734149 1734898 R DeoR family transcriptional regulator complement(1734149..1734898) Streptococcus pyogenes MGAS2096 4065141 YP_601379.1 CDS MGAS2096_Spy1783 NC_008023.1 1734964 1735794 D pyruvate formate-lyase activating enzyme 1734964..1735794 Streptococcus pyogenes MGAS2096 4065142 YP_601380.1 CDS MGAS2096_Spy1784 NC_008023.1 1735829 1736029 D hypothetical protein 1735829..1736029 Streptococcus pyogenes MGAS2096 4065143 YP_601381.1 CDS secE NC_008023.1 1736031 1736207 R forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE complement(1736031..1736207) Streptococcus pyogenes MGAS2096 4065144 YP_601382.1 CDS rpmG NC_008023.1 1736221 1736373 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 complement(1736221..1736373) Streptococcus pyogenes MGAS2096 4065145 YP_601383.1 CDS MGAS2096_Spy1787 NC_008023.1 1736422 1736595 R multimodular transpeptidase-transglycosylase PBP 2A complement(1736422..1736595) Streptococcus pyogenes MGAS2096 4065146 YP_601384.1 CDS pbp2A NC_008023.1 1736573 1738759 R multimodular transpeptidase-transglycosylase PBP 2A complement(1736573..1738759) Streptococcus pyogenes MGAS2096 4065147 YP_601385.1 CDS MGAS2096_Spy1789 NC_008023.1 1738798 1739178 R translation initiation inhibitor complement(1738798..1739178) Streptococcus pyogenes MGAS2096 4065148 YP_601386.1 CDS MGAS2096_Spy1790 NC_008023.1 1739669 1739860 D putative cytoplasmic protein 1739669..1739860 Streptococcus pyogenes MGAS2096 4065149 YP_601387.1 CDS MGAS2096_Spy1791 NC_008023.1 1739754 1740755 D ribosomal large subunit pseudouridine synthase D 1739754..1740755 Streptococcus pyogenes MGAS2096 4065150 YP_601388.1 CDS MGAS2096_Spy1792 NC_008023.1 1740844 1742568 R hypothetical protein complement(1740844..1742568) Streptococcus pyogenes MGAS2096 4065151 YP_601389.1 CDS MGAS2096_Spy1793 NC_008023.1 1742692 1744230 D dipeptidase 1742692..1744230 Streptococcus pyogenes MGAS2096 4065152 YP_601390.1 CDS MGAS2096_Spy1794 NC_008023.1 1744942 1745211 R MutR family transcriptional regulator complement(1744942..1745211) Streptococcus pyogenes MGAS2096 4065153 YP_601391.2 CDS groEL NC_008023.1 1745459 1747090 R 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL complement(1745459..1747090) Streptococcus pyogenes MGAS2096 4065154 YP_601392.2 CDS groES NC_008023.1 1747126 1747416 R 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES complement(1747126..1747416) Streptococcus pyogenes MGAS2096 4065155 YP_601393.1 CDS clpC NC_008023.1 1747594 1749012 R negative regulator of genetic competence clpC/mecB complement(1747594..1749012) Streptococcus pyogenes MGAS2096 4065557 YP_601394.1 CDS MGAS2096_Spy1798 NC_008023.1 1748969 1750039 R negative regulator of genetic competence clpC/mecB complement(1748969..1750039) Streptococcus pyogenes MGAS2096 4065558 YP_601395.1 CDS ctsR NC_008023.1 1750039 1750500 R transcriptional regulator ctsR complement(1750039..1750500) Streptococcus pyogenes MGAS2096 4065559 YP_601396.1 CDS csp NC_008023.1 1750696 1750905 R cold shock protein complement(1750696..1750905) Streptococcus pyogenes MGAS2096 4065560 YP_601397.1 CDS ahpC NC_008023.1 1751894 1752454 D peroxiredoxin 1751894..1752454 Streptococcus pyogenes MGAS2096 4065562 YP_601398.1 CDS ahpF NC_008023.1 1752475 1754007 D bifunctional; peroxiredoxin reductase (NAD(P)H) / NADH oxidase H2O2-forming 1752475..1754007 Streptococcus pyogenes MGAS2096 4065563 YP_601399.1 CDS hutI NC_008023.1 1754065 1755351 R catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway; imidazolonepropionase complement(1754065..1755351) Streptococcus pyogenes MGAS2096 4065564 YP_601400.1 CDS hutU NC_008023.1 1755621 1757651 D catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism; urocanate hydratase 1755621..1757651 Streptococcus pyogenes MGAS2096 4065565 YP_601401.1 CDS MGAS2096_Spy1805 NC_008023.1 1757739 1758638 D glutamate formiminotransferase 1757739..1758638 Streptococcus pyogenes MGAS2096 4065566 YP_601402.1 CDS MGAS2096_Spy1806 NC_008023.1 1758649 1759275 D formiminotetrahydrofolate cyclodeaminase 1758649..1759275 Streptococcus pyogenes MGAS2096 4065567 YP_601403.1 CDS fhs2 NC_008023.1 1759293 1760966 D catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase 1759293..1760966 Streptococcus pyogenes MGAS2096 4065568 YP_601404.1 CDS MGAS2096_Spy1808 NC_008023.1 1760967 1761584 D putative cytoplasmic protein 1760967..1761584 Streptococcus pyogenes MGAS2096 4065569 YP_601405.1 CDS MGAS2096_Spy1809 NC_008023.1 1761804 1763156 D amino acid permease 1761804..1763156 Streptococcus pyogenes MGAS2096 4065570 YP_601406.2 CDS hutH NC_008023.1 1763167 1764708 D catalyzes the degradation of histidine to urocanate and ammmonia; histidine ammonia-lyase 1763167..1764708 Streptococcus pyogenes MGAS2096 4065571 YP_601407.1 CDS hutG NC_008023.1 1764885 1765880 D catalyzes the formation of glutamate and formamide from N-formimidoyl-L-glutamate; formimidoylglutamase 1764885..1765880 Streptococcus pyogenes MGAS2096 4065572 YP_601408.1 CDS MGAS2096_Spy1812 NC_008023.1 1765911 1768985 R LuxR family transcriptional regulator complement(1765911..1768985) Streptococcus pyogenes MGAS2096 4065573 YP_601409.1 CDS rpsB NC_008023.1 1769289 1770056 D one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 1769289..1770056 Streptococcus pyogenes MGAS2096 4065574 YP_601410.2 CDS tsf NC_008023.1 1770190 1771230 D EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 1770190..1771230 Streptococcus pyogenes MGAS2096 4065712 YP_601411.1 CDS pepO NC_008023.1 1771397 1773292 R oligoendopeptidase O complement(1771397..1773292) Streptococcus pyogenes MGAS2096 4065713 YP_601412.1 CDS dexS NC_008023.1 1773500 1775128 R trehalose-6-phosphate hydrolase complement(1773500..1775128) Streptococcus pyogenes MGAS2096 4065714 YP_601413.1 CDS MGAS2096_Spy1817 NC_008023.1 1775195 1777219 R bifunctional; PTS system, trehalose-specific IIBC component / PTS system, trehalose-specific IIA component complement(1775195..1777219) Streptococcus pyogenes MGAS2096 4065715 YP_601414.1 CDS MGAS2096_Spy1818 NC_008023.1 1777430 1778143 D trehalose operon transcriptional repressor 1777430..1778143 Streptococcus pyogenes MGAS2096 4065716 YP_601415.1 CDS MGAS2096_Spy1819 NC_008023.1 1778422 1778760 R MarR family transcriptional regulator complement(1778422..1778760) Streptococcus pyogenes MGAS2096 4065717 YP_601416.1 CDS MGAS2096_Spy1820 NC_008023.1 1778946 1779701 D glyoxalase family protein 1778946..1779701 Streptococcus pyogenes MGAS2096 4065718 YP_601417.1 CDS yaaA NC_008023.1 1779836 1780567 D hypothetical protein 1779836..1780567 Streptococcus pyogenes MGAS2096 4065719 YP_601418.1 CDS nrdG NC_008023.1 1780741 1781358 R anaerobic ribonucleoside-triphosphate reductase activating protein complement(1780741..1781358) Streptococcus pyogenes MGAS2096 4065720 YP_601419.1 CDS MGAS2096_Spy1823 NC_008023.1 1781355 1781864 R acetyltransferase complement(1781355..1781864) Streptococcus pyogenes MGAS2096 4065721 YP_601420.1 CDS MGAS2096_Spy1824 NC_008023.1 1781873 1782814 R NAD-dependent oxidoreductase complement(1781873..1782814) Streptococcus pyogenes MGAS2096 4065722 YP_601421.1 CDS MGAS2096_Spy1825 NC_008023.1 1782837 1782983 R hypothetical protein complement(1782837..1782983) Streptococcus pyogenes MGAS2096 4065723 YP_601422.1 CDS nrdD NC_008023.1 1783165 1785363 R Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase complement(1783165..1785363) Streptococcus pyogenes MGAS2096 4065724 YP_601423.1 CDS MGAS2096_Spy1827 NC_008023.1 1785460 1787019 R hypothetical protein complement(1785460..1787019) Streptococcus pyogenes MGAS2096 4065725 YP_601424.1 CDS MGAS2096_Spy1828 NC_008023.1 1787470 1787736 R putative cytoplasmic protein complement(1787470..1787736) Streptococcus pyogenes MGAS2096 4065726 YP_601425.1 CDS MGAS2096_Spy1829 NC_008023.1 1787748 1788167 R similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein complement(1787748..1788167) Streptococcus pyogenes MGAS2096 4065727 YP_601426.1 CDS MGAS2096_Spy1830 NC_008023.1 1788164 1788433 R hypothetical protein complement(1788164..1788433) Streptococcus pyogenes MGAS2096 4065728 YP_601427.1 CDS spxA NC_008023.1 1788546 1788944 R the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx complement(1788546..1788944) Streptococcus pyogenes MGAS2096 4065729 YP_601428.1 CDS recA NC_008023.1 1789235 1790371 R catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A complement(1789235..1790371) Streptococcus pyogenes MGAS2096 4065730 YP_601429.1 CDS cinA NC_008023.1 1790460 1791731 R competence damage-inducible protein A complement(1790460..1791731) Streptococcus pyogenes MGAS2096 4065731 YP_601430.1 CDS tag NC_008023.1 1791800 1792369 R DNA-3-methyladenine glycosylase complement(1791800..1792369) Streptococcus pyogenes MGAS2096 4066260 YP_601431.1 CDS ruvA NC_008023.1 1792370 1792966 R plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA complement(1792370..1792966) Streptococcus pyogenes MGAS2096 4066261 YP_601432.1 CDS lmrP NC_008023.1 1792968 1794188 R multidrug resistance protein imrP complement(1792968..1794188) Streptococcus pyogenes MGAS2096 4066262 YP_601433.1 CDS mutL NC_008023.1 1794199 1796181 R This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein complement(1794199..1796181) Streptococcus pyogenes MGAS2096 4066263 YP_601434.1 CDS mutS NC_008023.1 1796310 1798865 R This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS complement(1796310..1798865) Streptococcus pyogenes MGAS2096 4066264 YP_601435.1 CDS argR2 NC_008023.1 1799205 1799642 R arginine repressor ArgR complement(1799205..1799642) Streptococcus pyogenes MGAS2096 4066265 YP_601436.1 CDS argS NC_008023.1 1799933 1801624 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1799933..1801624 Streptococcus pyogenes MGAS2096 4066266 YP_601437.1 CDS uviB NC_008023.1 1801694 1801939 D bacteriocin uviB 1801694..1801939 Streptococcus pyogenes MGAS2096 4066267 YP_601438.1 CDS MGAS2096_Spy1842 NC_008023.1 1802046 1802918 R hypothetical protein complement(1802046..1802918) Streptococcus pyogenes MGAS2096 4066268 YP_601439.1 CDS MGAS2096_Spy1843 NC_008023.1 1802961 1803914 R hypothetical protein complement(1802961..1803914) Streptococcus pyogenes MGAS2096 4066269 YP_601440.1 CDS MGAS2096_Spy1844 NC_008023.1 1803859 1804800 R hypothetical protein complement(1803859..1804800) Streptococcus pyogenes MGAS2096 4066270 YP_601441.1 CDS aspS NC_008023.1 1804793 1806592 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(1804793..1806592) Streptococcus pyogenes MGAS2096 4066271 YP_601442.2 CDS hisS NC_008023.1 1806879 1808159 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(1806879..1808159) Streptococcus pyogenes MGAS2096 4066272 YP_601443.1 CDS rpmF NC_008023.1 1808379 1808561 D some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1808379..1808561 Streptococcus pyogenes MGAS2096 4066273 YP_601444.1 CDS rpmG NC_008023.1 1808577 1808726 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 1808577..1808726 Streptococcus pyogenes MGAS2096 4066274 YP_601445.1 CDS cadD NC_008023.1 1809007 1809633 D cadmium resistance protein 1809007..1809633 Streptococcus pyogenes MGAS2096 4066275 YP_601446.1 CDS cadC NC_008023.1 1809615 1809983 D cadmium efflux system accessory protein 1809615..1809983 Streptococcus pyogenes MGAS2096 4066276 YP_601447.1 CDS MGAS2096_Spy1851 NC_008023.1 1810013 1810957 D hypothetical protein 1810013..1810957 Streptococcus pyogenes MGAS2096 4066277 YP_601448.1 CDS MGAS2096_Spy1852 NC_008023.1 1811023 1811775 D FtsK/SpoIIIE family protein 1811023..1811775 Streptococcus pyogenes MGAS2096 4066278 YP_601449.1 CDS MGAS2096_Spy1853 NC_008023.1 1811772 1812374 D hypothetical protein 1811772..1812374 Streptococcus pyogenes MGAS2096 4064981 YP_601450.1 CDS MGAS2096_Spy1854 NC_008023.1 1812754 1813038 R transcriptional regulator complement(1812754..1813038) Streptococcus pyogenes MGAS2096 4064982 YP_601451.1 CDS MGAS2096_Spy1855 NC_008023.1 1813246 1813404 R hypothetical protein complement(1813246..1813404) Streptococcus pyogenes MGAS2096 4064983 YP_601452.1 CDS MGAS2096_Spy1856 NC_008023.1 1813489 1814331 D integral membrane protein 1813489..1814331 Streptococcus pyogenes MGAS2096 4064984 YP_601453.1 CDS MGAS2096_Spy1857 NC_008023.1 1814378 1814800 R MutT/nudix family protein; phosphohydrolase complement(1814378..1814800) Streptococcus pyogenes MGAS2096 4064985 YP_601454.1 CDS MGAS2096_Spy1858 NC_008023.1 1814851 1815084 R hypothetical protein complement(1814851..1815084) Streptococcus pyogenes MGAS2096 4064986 YP_601455.1 CDS MGAS2096_Spy1859 NC_008023.1 1815224 1815550 D PadR family transcriptional regulator 1815224..1815550 Streptococcus pyogenes MGAS2096 4064987 YP_601456.1 CDS MGAS2096_Spy1860 NC_008023.1 1815537 1816124 D hypothetical protein 1815537..1816124 Streptococcus pyogenes MGAS2096 4064988 YP_601457.1 CDS MGAS2096_Spy1861 NC_008023.1 1816121 1817194 D hypothetical protein 1816121..1817194 Streptococcus pyogenes MGAS2096 4064989 YP_601458.1 CDS MGAS2096_Spy1862 NC_008023.1 1817311 1819614 R phage infection protein complement(1817311..1819614) Streptococcus pyogenes MGAS2096 4064990 YP_601459.1 CDS MGAS2096_Spy1863 NC_008023.1 1819719 1820252 D TetR family transcriptional regulator 1819719..1820252 Streptococcus pyogenes MGAS2096 4064991 YP_601460.1 CDS rpsD NC_008023.1 1820406 1821017 R primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 complement(1820406..1821017) Streptococcus pyogenes MGAS2096 4064992 YP_601461.1 CDS MGAS2096_Spy1865 NC_008023.1 1821747 1822049 R hypothetical protein complement(1821747..1822049) Streptococcus pyogenes MGAS2096 4064993 YP_601462.1 CDS holB NC_008023.1 1822036 1823412 R unwinds double stranded DNA; replicative DNA helicase complement(1822036..1823412) Streptococcus pyogenes MGAS2096 4064994 YP_601463.1 CDS rplI NC_008023.1 1823433 1823885 R in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 complement(1823433..1823885) Streptococcus pyogenes MGAS2096 4064995 YP_601464.1 CDS MGAS2096_Spy1868 NC_008023.1 1823882 1825918 R phosphoesterase, DHH family protein complement(1823882..1825918) Streptococcus pyogenes MGAS2096 4064996 YP_601465.1 CDS gidA NC_008023.1 1825948 1827846 R GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA complement(1825948..1827846) Streptococcus pyogenes MGAS2096 4064997 YP_601466.1 CDS MGAS2096_Spy1870 NC_008023.1 1828117 1828287 R MutT/nudix family protein; phosphohydrolase complement(1828117..1828287) Streptococcus pyogenes MGAS2096 4064998 YP_601467.1 CDS mnmA NC_008023.1 1829062 1830201 R catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA complement(1829062..1830201) Streptococcus pyogenes MGAS2096 4064999 YP_601468.1 CDS sdhB NC_008023.1 1830475 1831152 D L-serine dehydratase beta subunit 1830475..1831152 Streptococcus pyogenes MGAS2096 4065000 YP_601469.1 CDS sdhA NC_008023.1 1831164 1832036 D L-serine dehydratase alpha subunit 1831164..1832036 Streptococcus pyogenes MGAS2096 4066222 YP_601470.1 CDS MGAS2096_Spy1874 NC_008023.1 1832450 1833064 R transglycosylase complement(1832450..1833064) Streptococcus pyogenes MGAS2096 4066223 YP_601471.1 CDS cbiQ NC_008023.1 1833436 1834236 R hyaluronan ABC exporter permease complement(1833436..1834236) Streptococcus pyogenes MGAS2096 4066224 YP_601472.1 CDS cbiO NC_008023.1 1834229 1835071 R with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit complement(1834229..1835071) Streptococcus pyogenes MGAS2096 4066225 YP_601473.1 CDS cbiO NC_008023.1 1835047 1835937 R with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit complement(1835047..1835937) Streptococcus pyogenes MGAS2096 4066226 YP_601474.1 CDS MGAS2096_Spy1878 NC_008023.1 1835888 1836430 R CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase complement(1835888..1836430) Streptococcus pyogenes MGAS2096 4066227 YP_601475.1 CDS MGAS2096_Spy1879 NC_008023.1 1836444 1837469 R hypothetical protein complement(1836444..1837469) Streptococcus pyogenes MGAS2096 4066228 YP_601476.1 CDS MGAS2096_Spy1880 NC_008023.1 1837519 1838808 R Zinc protease complement(1837519..1838808) Streptococcus pyogenes MGAS2096 4066229 YP_601477.1 CDS MGAS2096_Spy1881 NC_008023.1 1838810 1840054 R M16 family peptidase complement(1838810..1840054) Streptococcus pyogenes MGAS2096 4066230 YP_601478.1 CDS hasA NC_008023.1 1840416 1841753 D hyaluronan synthase 1840416..1841753 Streptococcus pyogenes MGAS2096 4066231 YP_601479.1 CDS hasB NC_008023.1 1841789 1842997 D UDP-glucose 6-dehydrogenase 1841789..1842997 Streptococcus pyogenes MGAS2096 4066232 YP_601480.1 CDS hasC NC_008023.1 1843179 1844093 D UTP--glucose-1-phosphate uridylyltransferase 1843179..1844093 Streptococcus pyogenes MGAS2096 4066233 YP_601481.1 CDS MGAS2096_Spy1885 NC_008023.1 1844377 1844814 D putative cytoplasmic protein 1844377..1844814 Streptococcus pyogenes MGAS2096 4066234 YP_601482.1 CDS recF NC_008023.1 1844816 1845922 D Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 1844816..1845922 Streptococcus pyogenes MGAS2096 4066235 YP_601483.1 CDS MGAS2096_Spy1887 NC_008023.1 1845979 1846842 R glucose uptake family protein complement(1845979..1846842) Streptococcus pyogenes MGAS2096 4066236 YP_601484.1 CDS guaB NC_008023.1 1847045 1848526 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(1847045..1848526) Streptococcus pyogenes MGAS2096 4066237 YP_601485.2 CDS trsA NC_008023.1 1848834 1849856 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase II complement(1848834..1849856) Streptococcus pyogenes MGAS2096 4066238 YP_601486.1 CDS MGAS2096_Spy1890 NC_008023.1 1849948 1850073 R hypothetical protein complement(1849948..1850073) Streptococcus pyogenes MGAS2096 4066239 YP_601487.1 CDS MGAS2096_Spy1891 NC_008023.1 1850275 1851147 D hypothetical protein 1850275..1851147 Streptococcus pyogenes MGAS2096 4066240 YP_601488.1 CDS MGAS2096_Spy1892 NC_008023.1 1851226 1852845 D ABC transporter ATP-binding protein 1851226..1852845 Streptococcus pyogenes MGAS2096 4065215 YP_601489.1 CDS MGAS2096_Spy1893 NC_008023.1 1852928 1855504 D ABC transporter permease 1852928..1855504 Streptococcus pyogenes MGAS2096 4065216 YP_601490.1 CDS MGAS2096_Spy1894 NC_008023.1 1856375 1856962 R transposase complement(1856375..1856962) Streptococcus pyogenes MGAS2096 4065219 YP_601491.1 CDS MGAS2096_Spy1895 NC_008023.1 1856904 1857155 R transposase complement(1856904..1857155) Streptococcus pyogenes MGAS2096 4065220 YP_601492.1 CDS MGAS2096_Spy1896 NC_008023.1 1857545 1858024 R SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase complement(1857545..1858024) Streptococcus pyogenes MGAS2096 4065222 YP_601493.1 CDS htrA NC_008023.1 1858236 1859459 D endopeptidase degP 1858236..1859459 Streptococcus pyogenes MGAS2096 4065223 YP_601494.1 CDS parB NC_008023.1 1859518 1860324 D chromosome partitioning protein parB 1859518..1860324 Streptococcus pyogenes MGAS2096 4065224 MGAS2096_SPYR02221 tRNA MGAS2096_SPYR02221 NC_008023.1 22132 22204 D tRNA-Val 22132..22204 Streptococcus pyogenes MGAS2096 4066458 MGAS2096_SPYR02222 tRNA MGAS2096_SPYR02222 NC_008023.1 22222 22294 D tRNA-Asp 22222..22294 Streptococcus pyogenes MGAS2096 4066194 MGAS2096_SPYR02223 tRNA MGAS2096_SPYR02223 NC_008023.1 22326 22398 D tRNA-Lys 22326..22398 Streptococcus pyogenes MGAS2096 4066195 MGAS2096_SPYR02224 tRNA MGAS2096_SPYR02224 NC_008023.1 22404 22485 D tRNA-Leu 22404..22485 Streptococcus pyogenes MGAS2096 4066196 MGAS2096_SPYR02225 tRNA MGAS2096_SPYR02225 NC_008023.1 22496 22568 D tRNA-Thr 22496..22568 Streptococcus pyogenes MGAS2096 4066197 MGAS2096_SPYR02226 tRNA MGAS2096_SPYR02226 NC_008023.1 22581 22652 D tRNA-Gly 22581..22652 Streptococcus pyogenes MGAS2096 4066198 MGAS2096_SPYR02227 tRNA MGAS2096_SPYR02227 NC_008023.1 22661 22745 D tRNA-Leu 22661..22745 Streptococcus pyogenes MGAS2096 4066199 MGAS2096_SPYR02228 tRNA MGAS2096_SPYR02228 NC_008023.1 22762 22838 D tRNA-Arg 22762..22838 Streptococcus pyogenes MGAS2096 4066200 MGAS2096_SPYR02229 tRNA MGAS2096_SPYR02229 NC_008023.1 22842 22915 D tRNA-Pro 22842..22915 Streptococcus pyogenes MGAS2096 4066201 MGAS2096_SPYR02233 tRNA MGAS2096_SPYR02233 NC_008023.1 28133 28205 D tRNA-Val 28133..28205 Streptococcus pyogenes MGAS2096 4066394 MGAS2096_SPYR02234 tRNA MGAS2096_SPYR02234 NC_008023.1 28223 28295 D tRNA-Asp 28223..28295 Streptococcus pyogenes MGAS2096 4066395 MGAS2096_SPYR02235 tRNA MGAS2096_SPYR02235 NC_008023.1 28327 28399 D tRNA-Lys 28327..28399 Streptococcus pyogenes MGAS2096 4066396 MGAS2096_SPYR02236 tRNA MGAS2096_SPYR02236 NC_008023.1 28405 28486 D tRNA-Leu 28405..28486 Streptococcus pyogenes MGAS2096 4066397 MGAS2096_SPYR02237 tRNA MGAS2096_SPYR02237 NC_008023.1 28497 28569 D tRNA-Thr 28497..28569 Streptococcus pyogenes MGAS2096 4066398 MGAS2096_SPYR02238 tRNA MGAS2096_SPYR02238 NC_008023.1 28582 28653 D tRNA-Gly 28582..28653 Streptococcus pyogenes MGAS2096 4066399 MGAS2096_SPYR02239 tRNA MGAS2096_SPYR02239 NC_008023.1 28662 28746 D tRNA-Leu 28662..28746 Streptococcus pyogenes MGAS2096 4066400 MGAS2096_SPYR02240 tRNA MGAS2096_SPYR02240 NC_008023.1 28763 28839 D tRNA-Arg 28763..28839 Streptococcus pyogenes MGAS2096 4066401 MGAS2096_SPYR02241 tRNA MGAS2096_SPYR02241 NC_008023.1 28843 28916 D tRNA-Pro 28843..28916 Streptococcus pyogenes MGAS2096 4066279 MGAS2096_SPYR02242 tRNA MGAS2096_SPYR02242 NC_008023.1 28922 28995 D tRNA-Met 28922..28995 Streptococcus pyogenes MGAS2096 4066280 MGAS2096_SPYR02243 tRNA MGAS2096_SPYR02243 NC_008023.1 29016 29089 D tRNA-Met 29016..29089 Streptococcus pyogenes MGAS2096 4066281 MGAS2096_SPYR02244 tRNA MGAS2096_SPYR02244 NC_008023.1 29115 29197 D tRNA-OTHER 29115..29197 Streptococcus pyogenes MGAS2096 4066282 MGAS2096_SPYR02245 tRNA MGAS2096_SPYR02245 NC_008023.1 29211 29284 D tRNA-Met 29211..29284 Streptococcus pyogenes MGAS2096 4066283 MGAS2096_SPYR02246 tRNA MGAS2096_SPYR02246 NC_008023.1 29305 29377 D tRNA-Phe 29305..29377 Streptococcus pyogenes MGAS2096 4066284 MGAS2096_SPYR02247 tRNA MGAS2096_SPYR02247 NC_008023.1 29390 29460 D tRNA-Gly 29390..29460 Streptococcus pyogenes MGAS2096 4066285 MGAS2096_SPYR02248 tRNA MGAS2096_SPYR02248 NC_008023.1 29495 29568 D tRNA-Ile 29495..29568 Streptococcus pyogenes MGAS2096 4066286 MGAS2096_SPYR02249 tRNA MGAS2096_SPYR02249 NC_008023.1 29578 29665 D tRNA-Ser 29578..29665 Streptococcus pyogenes MGAS2096 4066287 MGAS2096_SPYR02253 tRNA MGAS2096_SPYR02253 NC_008023.1 84718 84790 D tRNA-Val 84718..84790 Streptococcus pyogenes MGAS2096 4065336 MGAS2096_SPYR02254 tRNA MGAS2096_SPYR02254 NC_008023.1 84796 84866 D tRNA-Gly 84796..84866 Streptococcus pyogenes MGAS2096 4065337 MGAS2096_SPYR02255 tRNA MGAS2096_SPYR02255 NC_008023.1 84901 84974 D tRNA-Ile 84901..84974 Streptococcus pyogenes MGAS2096 4065338 MGAS2096_SPYR02256 tRNA MGAS2096_SPYR02256 NC_008023.1 84997 85068 D tRNA-Glu 84997..85068 Streptococcus pyogenes MGAS2096 4065339 MGAS2096_SPYR02257 tRNA MGAS2096_SPYR02257 NC_008023.1 85082 85164 D tRNA-OTHER 85082..85164 Streptococcus pyogenes MGAS2096 4065340 MGAS2096_SPYR02258 tRNA MGAS2096_SPYR02258 NC_008023.1 85178 85251 D tRNA-Met 85178..85251 Streptococcus pyogenes MGAS2096 4065341 MGAS2096_SPYR02259 tRNA MGAS2096_SPYR02259 NC_008023.1 85272 85344 D tRNA-Phe 85272..85344 Streptococcus pyogenes MGAS2096 4066365 MGAS2096_SPYR02260 tRNA MGAS2096_SPYR02260 NC_008023.1 85364 85444 D tRNA-Tyr 85364..85444 Streptococcus pyogenes MGAS2096 4066366 MGAS2096_SPYR02261 tRNA MGAS2096_SPYR02261 NC_008023.1 85451 85521 D tRNA-Trp 85451..85521 Streptococcus pyogenes MGAS2096 4066367 MGAS2096_SPYR02262 tRNA MGAS2096_SPYR02262 NC_008023.1 85533 85605 D tRNA-His 85533..85605 Streptococcus pyogenes MGAS2096 4066368 MGAS2096_SPYR02263 tRNA MGAS2096_SPYR02263 NC_008023.1 85614 85685 D tRNA-Gln 85614..85685 Streptococcus pyogenes MGAS2096 4066369 MGAS2096_SPYR02264 tRNA MGAS2096_SPYR02264 NC_008023.1 85705 85788 D tRNA-Leu 85705..85788 Streptococcus pyogenes MGAS2096 4066370 MGAS2096_SPYR02268 tRNA MGAS2096_SPYR02268 NC_008023.1 277628 277701 D tRNA-Asn 277628..277701 Streptococcus pyogenes MGAS2096 4066380 MGAS2096_SPYR02269 tRNA MGAS2096_SPYR02269 NC_008023.1 277781 277854 D tRNA-Arg 277781..277854 Streptococcus pyogenes MGAS2096 4066381 MGAS2096_SPYR02270 tRNA MGAS2096_SPYR02270 NC_008023.1 582625 582696 D tRNA-Arg 582625..582696 Streptococcus pyogenes MGAS2096 4064839 MGAS2096_SPYR02271 tRNA MGAS2096_SPYR02271 NC_008023.1 759370 759450 D tRNA-Tyr 759370..759450 Streptococcus pyogenes MGAS2096 4066075 MGAS2096_SPYR02272 tRNA MGAS2096_SPYR02272 NC_008023.1 759502 759576 D tRNA-Gln 759502..759576 Streptococcus pyogenes MGAS2096 4066076 MGAS2096_SPYR02273 tRNA MGAS2096_SPYR02273 NC_008023.1 761018 761089 D tRNA-Arg 761018..761089 Streptococcus pyogenes MGAS2096 4066042 MGAS2096_SPYR02274 tRNA MGAS2096_SPYR02274 NC_008023.1 1271376 1271446 D tRNA-Thr 1271376..1271446 Streptococcus pyogenes MGAS2096 4064505 MGAS2096_SPYR02275 tRNA MGAS2096_SPYR02275 NC_008023.1 1303836 1303907 R tRNA-Glu complement(1303836..1303907) Streptococcus pyogenes MGAS2096 4064535 MGAS2096_SPYR02276 tRNA MGAS2096_SPYR02276 NC_008023.1 1303930 1304003 R tRNA-Ile complement(1303930..1304003) Streptococcus pyogenes MGAS2096 4064536 MGAS2096_SPYR02277 tRNA MGAS2096_SPYR02277 NC_008023.1 1304039 1304111 R tRNA-Thr complement(1304039..1304111) Streptococcus pyogenes MGAS2096 4064537 MGAS2096_SPYR02278 tRNA MGAS2096_SPYR02278 NC_008023.1 1304122 1304203 R tRNA-Leu complement(1304122..1304203) Streptococcus pyogenes MGAS2096 4065322 MGAS2096_SPYR02279 tRNA MGAS2096_SPYR02279 NC_008023.1 1304209 1304281 R tRNA-Lys complement(1304209..1304281) Streptococcus pyogenes MGAS2096 4065323 MGAS2096_SPYR02280 tRNA MGAS2096_SPYR02280 NC_008023.1 1304313 1304385 R tRNA-Asp complement(1304313..1304385) Streptococcus pyogenes MGAS2096 4065324 MGAS2096_SPYR02281 tRNA MGAS2096_SPYR02281 NC_008023.1 1304403 1304475 R tRNA-Val complement(1304403..1304475) Streptococcus pyogenes MGAS2096 4065325 MGAS2096_SPYR02284 tRNA MGAS2096_SPYR02284 NC_008023.1 1307892 1307967 R tRNA-Ala complement(1307892..1307967) Streptococcus pyogenes MGAS2096 4065328 MGAS2096_SPYR02286 tRNA MGAS2096_SPYR02286 NC_008023.1 1444350 1444436 R tRNA-Ser complement(1444350..1444436) Streptococcus pyogenes MGAS2096 4064606 MGAS2096_SPYR02287 tRNA MGAS2096_SPYR02287 NC_008023.1 1582243 1582328 R tRNA-Leu complement(1582243..1582328) Streptococcus pyogenes MGAS2096 4066190 MGAS2096_SPYR02288 tRNA MGAS2096_SPYR02288 NC_008023.1 1591936 1592009 R tRNA-Arg complement(1591936..1592009) Streptococcus pyogenes MGAS2096 4064799 MGAS2096_SPYR02289 tRNA MGAS2096_SPYR02289 NC_008023.1 1592089 1592162 R tRNA-Asn complement(1592089..1592162) Streptococcus pyogenes MGAS2096 4064800 MGAS2096_SPYR02292 tRNA MGAS2096_SPYR02292 NC_008023.1 1595567 1595642 R tRNA-Ala complement(1595567..1595642) Streptococcus pyogenes MGAS2096 4064803 MGAS2096_SPYR02294 tRNA MGAS2096_SPYR02294 NC_008023.1 1680750 1680822 D tRNA-Lys 1680750..1680822 Streptococcus pyogenes MGAS2096 4065913 MGAS2096_SPYR02295 tRNA MGAS2096_SPYR02295 NC_008023.1 1751418 1751488 R tRNA-Cys complement(1751418..1751488) Streptococcus pyogenes MGAS2096 4065561 MGAS2096_SPYR02296 tRNA MGAS2096_SPYR02296 NC_008023.1 1856001 1856074 R tRNA-Asn complement(1856001..1856074) Streptococcus pyogenes MGAS2096 4065217 MGAS2096_SPYR02297 tRNA MGAS2096_SPYR02297 NC_008023.1 1856108 1856179 R tRNA-Glu complement(1856108..1856179) Streptococcus pyogenes MGAS2096 4065218 MGAS2096_SPYR02298 tRNA MGAS2096_SPYR02298 NC_008023.1 1857314 1857387 D tRNA-Arg 1857314..1857387 Streptococcus pyogenes MGAS2096 4065221 MGAS2096_SPYR02218 rRNA MGAS2096_SPYR02218 NC_008023.1 17058 18886 D 16S small subunit ribosomal RNA 17058..18886 Streptococcus pyogenes MGAS2096 4066455 MGAS2096_SPYR02219 rRNA MGAS2096_SPYR02219 NC_008023.1 19011 21913 D 23S large subunit ribosomal RNA 19011..21913 Streptococcus pyogenes MGAS2096 4066456 MGAS2096_SPYR02220 rRNA MGAS2096_SPYR02220 NC_008023.1 21998 22114 D 5S RNA 21998..22114 Streptococcus pyogenes MGAS2096 4066457 MGAS2096_SPYR02230 rRNA MGAS2096_SPYR02230 NC_008023.1 23059 24887 D 16S small subunit ribosomal RNA 23059..24887 Streptococcus pyogenes MGAS2096 4066202 MGAS2096_SPYR02231 rRNA MGAS2096_SPYR02231 NC_008023.1 25012 27914 D 23S large subunit ribosomal RNA 25012..27914 Streptococcus pyogenes MGAS2096 4066392 MGAS2096_SPYR02232 rRNA MGAS2096_SPYR02232 NC_008023.1 27999 28115 D 5S RNA 27999..28115 Streptococcus pyogenes MGAS2096 4066393 MGAS2096_SPYR02250 rRNA MGAS2096_SPYR02250 NC_008023.1 79644 81472 D 16S small subunit ribosomal RNA 79644..81472 Streptococcus pyogenes MGAS2096 4065333 MGAS2096_SPYR02251 rRNA MGAS2096_SPYR02251 NC_008023.1 81597 84499 D 23S large subunit ribosomal RNA 81597..84499 Streptococcus pyogenes MGAS2096 4065334 MGAS2096_SPYR02252 rRNA MGAS2096_SPYR02252 NC_008023.1 84584 84700 D 5S RNA 84584..84700 Streptococcus pyogenes MGAS2096 4065335 MGAS2096_SPYR02265 rRNA MGAS2096_SPYR02265 NC_008023.1 272566 274394 D 16S small subunit ribosomal RNA 272566..274394 Streptococcus pyogenes MGAS2096 4064653 MGAS2096_SPYR02266 rRNA MGAS2096_SPYR02266 NC_008023.1 274519 277421 D 23S large subunit ribosomal RNA 274519..277421 Streptococcus pyogenes MGAS2096 4066378 MGAS2096_SPYR02267 rRNA MGAS2096_SPYR02267 NC_008023.1 277506 277622 D 5S RNA 277506..277622 Streptococcus pyogenes MGAS2096 4066379 MGAS2096_SPYR02282 rRNA MGAS2096_SPYR02282 NC_008023.1 1304498 1304604 R 5S RNA complement(1304498..1304604) Streptococcus pyogenes MGAS2096 4065326 MGAS2096_SPYR02283 rRNA MGAS2096_SPYR02283 NC_008023.1 1304696 1307594 R 23S large subunit ribosomal RNA complement(1304696..1307594) Streptococcus pyogenes MGAS2096 4065327 MGAS2096_SPYR02285 rRNA MGAS2096_SPYR02285 NC_008023.1 1308020 1309250 R 16S small subunit ribosomal RNA complement(1308020..1309250) Streptococcus pyogenes MGAS2096 4065329 MGAS2096_SPYR02290 rRNA MGAS2096_SPYR02290 NC_008023.1 1592173 1592279 R 5S RNA complement(1592173..1592279) Streptococcus pyogenes MGAS2096 4064801 MGAS2096_SPYR02291 rRNA MGAS2096_SPYR02291 NC_008023.1 1592371 1595269 R 23S large subunit ribosomal RNA complement(1592371..1595269) Streptococcus pyogenes MGAS2096 4064802 MGAS2096_SPYR02293 rRNA MGAS2096_SPYR02293 NC_008023.1 1595695 1596925 R 16S small subunit ribosomal RNA complement(1595695..1596925) Streptococcus pyogenes MGAS2096 4064804