-- dump date 20120504_162933 -- class Genbank::misc_feature -- table misc_feature_note -- id note 370565000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 370565000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370565000003 Walker A motif; other site 370565000004 ATP binding site [chemical binding]; other site 370565000005 Walker B motif; other site 370565000006 arginine finger; other site 370565000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 370565000008 DnaA box-binding interface [nucleotide binding]; other site 370565000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 370565000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 370565000011 putative DNA binding surface [nucleotide binding]; other site 370565000012 dimer interface [polypeptide binding]; other site 370565000013 beta-clamp/clamp loader binding surface; other site 370565000014 beta-clamp/translesion DNA polymerase binding surface; other site 370565000015 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 370565000016 GTP-binding protein YchF; Reviewed; Region: PRK09601 370565000017 YchF GTPase; Region: YchF; cd01900 370565000018 G1 box; other site 370565000019 GTP/Mg2+ binding site [chemical binding]; other site 370565000020 Switch I region; other site 370565000021 G2 box; other site 370565000022 Switch II region; other site 370565000023 G3 box; other site 370565000024 G4 box; other site 370565000025 G5 box; other site 370565000026 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 370565000027 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 370565000028 putative active site [active] 370565000029 catalytic residue [active] 370565000030 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 370565000031 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 370565000032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 370565000033 ATP binding site [chemical binding]; other site 370565000034 putative Mg++ binding site [ion binding]; other site 370565000035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 370565000036 nucleotide binding region [chemical binding]; other site 370565000037 ATP-binding site [chemical binding]; other site 370565000038 TRCF domain; Region: TRCF; cl04088 370565000039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 370565000040 Septum formation initiator; Region: DivIC; cl11433 370565000041 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 370565000042 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 370565000043 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 370565000044 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 370565000045 Ligand Binding Site [chemical binding]; other site 370565000046 B3/4 domain; Region: B3_4; cl11458 370565000047 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 370565000048 active site 370565000049 FtsH Extracellular; Region: FtsH_ext; pfam06480 370565000050 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 370565000051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370565000052 Walker A motif; other site 370565000053 ATP binding site [chemical binding]; other site 370565000054 Walker B motif; other site 370565000055 arginine finger; other site 370565000056 Peptidase family M41; Region: Peptidase_M41; pfam01434 370565000057 amino acid transporter; Region: 2A0306; TIGR00909 370565000058 Spore germination protein; Region: Spore_permease; cl15802 370565000059 Spore germination protein; Region: Spore_permease; cl15802 370565000060 Transposase; Region: DDE_Tnp_ISL3; pfam01610 370565000061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 370565000062 NlpC/P60 family; Region: NLPC_P60; cl11438 370565000063 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 370565000064 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 370565000065 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 370565000066 active site 370565000067 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 370565000068 Recombination protein O N terminal; Region: RecO_N; cl15812 370565000069 Recombination protein O C terminal; Region: RecO_C; pfam02565 370565000070 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 370565000071 Phosphopantetheine attachment site; Region: PP-binding; cl09936 370565000072 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 370565000073 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 370565000074 ATP binding site [chemical binding]; other site 370565000075 active site 370565000076 substrate binding site [chemical binding]; other site 370565000077 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 370565000078 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 370565000079 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 370565000080 dimerization interface [polypeptide binding]; other site 370565000081 ATP binding site [chemical binding]; other site 370565000082 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 370565000083 dimerization interface [polypeptide binding]; other site 370565000084 ATP binding site [chemical binding]; other site 370565000085 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 370565000086 putative active site [active] 370565000087 catalytic triad [active] 370565000088 amidophosphoribosyltransferase; Provisional; Region: PRK07272 370565000089 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 370565000090 active site 370565000091 tetramer interface [polypeptide binding]; other site 370565000092 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 370565000093 active site 370565000094 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 370565000095 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 370565000096 dimerization interface [polypeptide binding]; other site 370565000097 putative ATP binding site [chemical binding]; other site 370565000098 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 370565000099 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 370565000100 active site 370565000101 substrate binding site [chemical binding]; other site 370565000102 cosubstrate binding site; other site 370565000103 catalytic site [active] 370565000104 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 370565000105 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 370565000106 purine monophosphate binding site [chemical binding]; other site 370565000107 dimer interface [polypeptide binding]; other site 370565000108 putative catalytic residues [active] 370565000109 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 370565000110 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 370565000111 Surface antigen [General function prediction only]; Region: COG3942 370565000112 NlpC/P60 family; Region: NLPC_P60; cl11438 370565000113 Bacterial SH3 domain; Region: SH3_3; cl02551 370565000114 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 370565000115 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 370565000116 ATP-grasp domain; Region: ATP-grasp_4; cl03087 370565000117 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 370565000118 AIR carboxylase; Region: AIRC; cl00310 370565000119 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 370565000120 ATP-grasp domain; Region: ATP-grasp_4; cl03087 370565000121 adenylosuccinate lyase; Provisional; Region: PRK07492 370565000122 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 370565000123 tetramer interface [polypeptide binding]; other site 370565000124 active site 370565000125 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370565000126 non-specific DNA binding site [nucleotide binding]; other site 370565000127 salt bridge; other site 370565000128 sequence-specific DNA binding site [nucleotide binding]; other site 370565000129 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 370565000130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370565000131 Walker A motif; other site 370565000132 ATP binding site [chemical binding]; other site 370565000133 Walker B motif; other site 370565000134 arginine finger; other site 370565000135 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 370565000136 Low molecular weight phosphatase family; Region: LMWPc; cd00115 370565000137 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 370565000138 active site 370565000139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 370565000140 MORN repeat; Region: MORN; cl14787 370565000141 OpgC protein; Region: OpgC_C; cl00792 370565000142 Acyltransferase family; Region: Acyl_transf_3; pfam01757 370565000143 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 370565000144 catalytic triad [active] 370565000145 catalytic triad [active] 370565000146 oxyanion hole [active] 370565000147 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 370565000148 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 370565000149 putative catalytic cysteine [active] 370565000150 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 370565000151 putative active site [active] 370565000152 metal binding site [ion binding]; metal-binding site 370565000153 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 370565000154 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 370565000155 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 370565000156 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 370565000157 MatE; Region: MatE; cl10513 370565000158 MatE; Region: MatE; cl10513 370565000159 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 370565000160 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 370565000161 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 370565000162 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 370565000163 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 370565000164 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 370565000165 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 370565000166 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 370565000167 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 370565000168 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 370565000169 putative translocon binding site; other site 370565000170 protein-rRNA interface [nucleotide binding]; other site 370565000171 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 370565000172 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 370565000173 G-X-X-G motif; other site 370565000174 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 370565000175 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 370565000176 23S rRNA interface [nucleotide binding]; other site 370565000177 5S rRNA interface [nucleotide binding]; other site 370565000178 putative antibiotic binding site [chemical binding]; other site 370565000179 L25 interface [polypeptide binding]; other site 370565000180 L27 interface [polypeptide binding]; other site 370565000181 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 370565000182 23S rRNA interface [nucleotide binding]; other site 370565000183 putative translocon interaction site; other site 370565000184 signal recognition particle (SRP54) interaction site; other site 370565000185 L23 interface [polypeptide binding]; other site 370565000186 trigger factor interaction site; other site 370565000187 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 370565000188 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 370565000189 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 370565000190 KOW motif; Region: KOW; cl00354 370565000191 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 370565000192 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 370565000193 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 370565000194 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 370565000195 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 370565000196 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 370565000197 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 370565000198 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 370565000199 5S rRNA interface [nucleotide binding]; other site 370565000200 L27 interface [polypeptide binding]; other site 370565000201 23S rRNA interface [nucleotide binding]; other site 370565000202 L5 interface [polypeptide binding]; other site 370565000203 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 370565000204 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 370565000205 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 370565000206 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 370565000207 23S rRNA binding site [nucleotide binding]; other site 370565000208 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 370565000209 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 370565000210 SecY translocase; Region: SecY; pfam00344 370565000211 adenylate kinase; Reviewed; Region: adk; PRK00279 370565000212 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 370565000213 AMP-binding site [chemical binding]; other site 370565000214 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 370565000215 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 370565000216 rRNA binding site [nucleotide binding]; other site 370565000217 predicted 30S ribosome binding site; other site 370565000218 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 370565000219 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 370565000220 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 370565000221 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 370565000222 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 370565000223 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 370565000224 alphaNTD homodimer interface [polypeptide binding]; other site 370565000225 alphaNTD - beta interaction site [polypeptide binding]; other site 370565000226 alphaNTD - beta' interaction site [polypeptide binding]; other site 370565000227 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 370565000228 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 370565000229 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 370565000230 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 370565000231 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 370565000232 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 370565000233 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 370565000234 Helix-turn-helix domains; Region: HTH; cl00088 370565000235 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 370565000236 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 370565000237 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 370565000238 ABC-ATPase subunit interface; other site 370565000239 dimer interface [polypeptide binding]; other site 370565000240 putative PBP binding regions; other site 370565000241 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 370565000242 nucleotide binding site/active site [active] 370565000243 HIT family signature motif; other site 370565000244 catalytic residue [active] 370565000245 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 370565000246 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 370565000247 active site 370565000248 HIGH motif; other site 370565000249 dimer interface [polypeptide binding]; other site 370565000250 KMSKS motif; other site 370565000251 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 370565000252 RNA binding surface [nucleotide binding]; other site 370565000253 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 370565000254 Transglycosylase; Region: Transgly; cl07896 370565000255 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 370565000256 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 370565000257 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 370565000258 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 370565000259 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 370565000260 RPB1 interaction site [polypeptide binding]; other site 370565000261 RPB10 interaction site [polypeptide binding]; other site 370565000262 RPB11 interaction site [polypeptide binding]; other site 370565000263 RPB3 interaction site [polypeptide binding]; other site 370565000264 RPB12 interaction site [polypeptide binding]; other site 370565000265 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 370565000266 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 370565000267 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 370565000268 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 370565000269 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 370565000270 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 370565000271 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 370565000272 G-loop; other site 370565000273 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 370565000274 DNA binding site [nucleotide binding] 370565000275 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 370565000276 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 370565000277 Type II/IV secretion system protein; Region: T2SE; pfam00437 370565000278 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565000279 Walker A motif; other site 370565000280 ATP binding site [chemical binding]; other site 370565000281 Walker B motif; other site 370565000282 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 370565000283 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 370565000284 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 370565000285 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 370565000286 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 370565000287 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 370565000288 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 370565000289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 370565000290 acetate kinase; Region: ackA; TIGR00016 370565000291 Acetokinase family; Region: Acetate_kinase; cl01029 370565000292 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 370565000293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565000294 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 370565000295 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 370565000296 metal binding site [ion binding]; metal-binding site 370565000297 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 370565000298 catalytic residues [active] 370565000299 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 370565000300 putative tRNA-binding site [nucleotide binding]; other site 370565000301 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 370565000302 dimer interface [polypeptide binding]; other site 370565000303 ssDNA binding site [nucleotide binding]; other site 370565000304 tetramer (dimer of dimers) interface [polypeptide binding]; other site 370565000305 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 370565000306 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 370565000307 Substrate-binding site [chemical binding]; other site 370565000308 Substrate specificity [chemical binding]; other site 370565000309 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 370565000310 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 370565000311 FMN binding site [chemical binding]; other site 370565000312 active site 370565000313 catalytic residues [active] 370565000314 substrate binding site [chemical binding]; other site 370565000315 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 370565000316 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 370565000317 dimerization interface [polypeptide binding]; other site 370565000318 domain crossover interface; other site 370565000319 redox-dependent activation switch; other site 370565000320 Helix-turn-helix domains; Region: HTH; cl00088 370565000321 Helix-turn-helix domains; Region: HTH; cl00088 370565000322 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 370565000323 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 370565000324 TQXA domain; Region: TQXA_dom; TIGR03934 370565000325 Fibronectin binding repeat; Region: Fn_bind; pfam02986 370565000326 Fibronectin binding repeat; Region: Fn_bind; pfam02986 370565000327 Fibronectin binding repeat; Region: Fn_bind; pfam02986 370565000328 Fibronectin binding repeat; Region: Fn_bind; pfam02986 370565000329 Fibronectin binding repeat; Region: Fn_bind; pfam02986 370565000330 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 370565000331 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 370565000332 active site 370565000333 catalytic site [active] 370565000334 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 370565000335 TQXA domain; Region: TQXA_dom; TIGR03934 370565000336 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 370565000337 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 370565000338 TQXA domain; Region: TQXA_dom; TIGR03934 370565000339 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 370565000340 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 370565000341 Catalytic site [active] 370565000342 T surface-antigen of pili; Region: FctA; cl16948 370565000343 sortase B signal domain, QVPTGV class; Region: srtB_sig_QVPTGV; TIGR03065 370565000344 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 370565000345 active site 370565000346 catalytic site [active] 370565000347 T surface-antigen of pili; Region: FctA; cl16948 370565000348 YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094 370565000349 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 370565000350 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 370565000351 C-terminus of bacterial fibrinogen-binding adhesin; Region: SdrG_C_C; pfam10425 370565000352 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 370565000353 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cd00222 370565000354 domain interaction interfaces; other site 370565000355 putative Ca2+ binding sites [ion binding]; other site 370565000356 putative ligand binding motif; other site 370565000357 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 370565000358 Fibronectin binding repeat; Region: Fn_bind; pfam02986 370565000359 Fibronectin binding repeat; Region: Fn_bind; pfam02986 370565000360 Fibronectin binding repeat; Region: Fn_bind; pfam02986 370565000361 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 370565000362 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 370565000363 Helix-turn-helix domains; Region: HTH; cl00088 370565000364 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 370565000365 dimerization interface [polypeptide binding]; other site 370565000366 putative acyltransferase; Provisional; Region: PRK05790 370565000367 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 370565000368 dimer interface [polypeptide binding]; other site 370565000369 active site 370565000370 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370565000371 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370565000372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 370565000373 YheO-like PAS domain; Region: PAS_6; pfam08348 370565000374 Helix-turn-helix domains; Region: HTH; cl00088 370565000375 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 370565000376 homotrimer interaction site [polypeptide binding]; other site 370565000377 putative active site [active] 370565000378 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 370565000379 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 370565000380 V-type ATP synthase subunit I; Validated; Region: PRK05771 370565000381 V-type ATP synthase subunit K; Validated; Region: PRK06558 370565000382 ATP synthase subunit C; Region: ATP-synt_C; cl00466 370565000383 ATP synthase subunit C; Region: ATP-synt_C; cl00466 370565000384 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 370565000385 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 370565000386 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 370565000387 V-type ATP synthase subunit A; Provisional; Region: PRK04192 370565000388 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 370565000389 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 370565000390 Walker A motif/ATP binding site; other site 370565000391 Walker B motif; other site 370565000392 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 370565000393 V-type ATP synthase subunit B; Provisional; Region: PRK04196 370565000394 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 370565000395 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 370565000396 Walker A motif homologous position; other site 370565000397 Walker B motif; other site 370565000398 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 370565000399 ATP synthase subunit D; Region: ATP-synt_D; cl00613 370565000400 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 370565000401 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565000402 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 370565000403 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 370565000404 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 370565000405 ligand binding site [chemical binding]; other site 370565000406 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 370565000407 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 370565000408 putative homodimer interface [polypeptide binding]; other site 370565000409 KOW motif; Region: KOW; cl00354 370565000410 Nicotine adenine dinucleotide glycohydrolase (NADase); Region: NADase_NGA; pfam07461 370565000411 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 370565000412 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 370565000413 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 370565000414 catalytic residue [active] 370565000415 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 370565000416 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 370565000417 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 370565000418 HIGH motif; other site 370565000419 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 370565000420 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 370565000421 active site 370565000422 KMSKS motif; other site 370565000423 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 370565000424 tRNA binding surface [nucleotide binding]; other site 370565000425 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 370565000426 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 370565000427 DDE superfamily endonuclease; Region: DDE_4; cl15789 370565000428 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 370565000429 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 370565000430 active site 370565000431 P-loop; other site 370565000432 phosphorylation site [posttranslational modification] 370565000433 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 370565000434 active site 370565000435 phosphorylation site [posttranslational modification] 370565000436 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 370565000437 active site 370565000438 dimer interface [polypeptide binding]; other site 370565000439 magnesium binding site [ion binding]; other site 370565000440 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 370565000441 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 370565000442 AP (apurinic/apyrimidinic) site pocket; other site 370565000443 DNA interaction; other site 370565000444 Metal-binding active site; metal-binding site 370565000445 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 370565000446 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 370565000447 intersubunit interface [polypeptide binding]; other site 370565000448 active site 370565000449 Zn2+ binding site [ion binding]; other site 370565000450 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 370565000451 Helix-turn-helix domains; Region: HTH; cl00088 370565000452 PRD domain; Region: PRD; cl15445 370565000453 PRD domain; Region: PRD; cl15445 370565000454 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 370565000455 active site 370565000456 P-loop; other site 370565000457 phosphorylation site [posttranslational modification] 370565000458 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370565000459 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565000460 Walker A/P-loop; other site 370565000461 ATP binding site [chemical binding]; other site 370565000462 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565000463 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 370565000464 Q-loop/lid; other site 370565000465 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565000466 ABC transporter signature motif; other site 370565000467 Walker B; other site 370565000468 D-loop; other site 370565000469 H-loop/switch region; other site 370565000470 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 370565000471 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 370565000472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370565000473 dimer interface [polypeptide binding]; other site 370565000474 conserved gate region; other site 370565000475 putative PBP binding loops; other site 370565000476 ABC-ATPase subunit interface; other site 370565000477 NMT1-like family; Region: NMT1_2; cl15260 370565000478 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 370565000479 DNA polymerase I; Provisional; Region: PRK05755 370565000480 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 370565000481 putative 5' ssDNA interaction site; other site 370565000482 active site 370565000483 metal binding site 3; metal-binding site 370565000484 metal binding site 1 [ion binding]; metal-binding site 370565000485 metal binding site 2 [ion binding]; metal-binding site 370565000486 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 370565000487 putative DNA binding site [nucleotide binding]; other site 370565000488 putative metal binding site [ion binding]; other site 370565000489 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 370565000490 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 370565000491 active site 370565000492 DNA binding site [nucleotide binding] 370565000493 catalytic site [active] 370565000494 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565000495 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 370565000496 metal binding site 2 [ion binding]; metal-binding site 370565000497 putative DNA binding helix; other site 370565000498 metal binding site 1 [ion binding]; metal-binding site 370565000499 dimer interface [polypeptide binding]; other site 370565000500 structural Zn2+ binding site [ion binding]; other site 370565000501 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 370565000502 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 370565000503 Active Sites [active] 370565000504 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 370565000505 ParB-like nuclease domain; Region: ParBc; cl02129 370565000506 Transposase; Region: DDE_Tnp_ISL3; pfam01610 370565000507 Integrase core domain; Region: rve_3; cl15866 370565000508 HTH-like domain; Region: HTH_21; pfam13276 370565000509 Integrase core domain; Region: rve; cl01316 370565000510 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 370565000511 transmembrane helices; other site 370565000512 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06559 370565000513 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 370565000514 dimerization interface [polypeptide binding]; other site 370565000515 active site 370565000516 putative transposase OrfB; Reviewed; Region: PHA02517 370565000517 HTH-like domain; Region: HTH_21; pfam13276 370565000518 Integrase core domain; Region: rve; cl01316 370565000519 Integrase core domain; Region: rve_3; cl15866 370565000520 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 370565000521 Helix-turn-helix domains; Region: HTH; cl00088 370565000522 Protein of unknown function (DUF975); Region: DUF975; cl10504 370565000523 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 370565000524 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 370565000525 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 370565000526 CHY zinc finger; Region: zf-CHY; pfam05495 370565000527 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 370565000528 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 370565000529 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 370565000530 Transposase [DNA replication, recombination, and repair]; Region: COG5433 370565000531 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370565000532 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 370565000533 nucleoside/Zn binding site; other site 370565000534 dimer interface [polypeptide binding]; other site 370565000535 catalytic motif [active] 370565000536 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 370565000537 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 370565000538 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 370565000539 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 370565000540 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 370565000541 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 370565000542 active site 370565000543 dimer interface [polypeptide binding]; other site 370565000544 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 370565000545 dimer interface [polypeptide binding]; other site 370565000546 active site 370565000547 Helix-turn-helix domains; Region: HTH; cl00088 370565000548 Helix-turn-helix domains; Region: HTH; cl00088 370565000549 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 370565000550 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 370565000551 Transposase [DNA replication, recombination, and repair]; Region: COG5433 370565000552 Rhomboid family; Region: Rhomboid; cl11446 370565000553 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 370565000554 active site 370565000555 tetramer interface; other site 370565000556 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 370565000557 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565000558 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 370565000559 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 370565000560 Helix-turn-helix domains; Region: HTH; cl00088 370565000561 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 370565000562 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 370565000563 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565000564 Walker A/P-loop; other site 370565000565 ATP binding site [chemical binding]; other site 370565000566 Q-loop/lid; other site 370565000567 ABC transporter signature motif; other site 370565000568 Walker B; other site 370565000569 D-loop; other site 370565000570 H-loop/switch region; other site 370565000571 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 370565000572 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 370565000573 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 370565000574 Walker A/P-loop; other site 370565000575 ATP binding site [chemical binding]; other site 370565000576 Q-loop/lid; other site 370565000577 ABC transporter signature motif; other site 370565000578 Walker B; other site 370565000579 D-loop; other site 370565000580 H-loop/switch region; other site 370565000581 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 370565000582 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 370565000583 trimer interface [polypeptide binding]; other site 370565000584 active site 370565000585 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 370565000586 DNA repair protein RadA; Provisional; Region: PRK11823 370565000587 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 370565000588 Walker A motif/ATP binding site; other site 370565000589 ATP binding site [chemical binding]; other site 370565000590 Walker B motif; other site 370565000591 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 370565000592 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 370565000593 active site clefts [active] 370565000594 zinc binding site [ion binding]; other site 370565000595 dimer interface [polypeptide binding]; other site 370565000596 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 370565000597 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 370565000598 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 370565000599 active site 370565000600 HIGH motif; other site 370565000601 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 370565000602 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 370565000603 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 370565000604 KMSKS motif; other site 370565000605 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 370565000606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 370565000607 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 370565000608 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 370565000609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370565000610 active site 370565000611 phosphorylation site [posttranslational modification] 370565000612 intermolecular recognition site; other site 370565000613 dimerization interface [polypeptide binding]; other site 370565000614 LytTr DNA-binding domain; Region: LytTR; cl04498 370565000615 Ribonuclease P; Region: Ribonuclease_P; cl00457 370565000616 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 370565000617 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 370565000618 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 370565000619 G-X-X-G motif; other site 370565000620 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 370565000621 RxxxH motif; other site 370565000622 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 370565000623 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 370565000624 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 370565000625 putative active site cavity [active] 370565000626 hypothetical protein; Provisional; Region: PRK11615 370565000627 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 370565000628 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 370565000629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370565000630 dimer interface [polypeptide binding]; other site 370565000631 ABC-ATPase subunit interface; other site 370565000632 putative PBP binding loops; other site 370565000633 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 370565000634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370565000635 dimer interface [polypeptide binding]; other site 370565000636 conserved gate region; other site 370565000637 putative PBP binding loops; other site 370565000638 ABC-ATPase subunit interface; other site 370565000639 Protein of unknown function, DUF624; Region: DUF624; cl02369 370565000640 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 370565000641 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 370565000642 catalytic residue [active] 370565000643 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 370565000644 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 370565000645 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 370565000646 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 370565000647 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 370565000648 putative active site [active] 370565000649 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 370565000650 active site 370565000651 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 370565000652 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 370565000653 putative active site [active] 370565000654 putative metal binding site [ion binding]; other site 370565000655 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 370565000656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 370565000657 GTPase RsgA; Reviewed; Region: PRK00098 370565000658 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 370565000659 RNA binding site [nucleotide binding]; other site 370565000660 homodimer interface [polypeptide binding]; other site 370565000661 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 370565000662 GTPase/Zn-binding domain interface [polypeptide binding]; other site 370565000663 GTP/Mg2+ binding site [chemical binding]; other site 370565000664 G4 box; other site 370565000665 G1 box; other site 370565000666 Switch I region; other site 370565000667 G2 box; other site 370565000668 G3 box; other site 370565000669 Switch II region; other site 370565000670 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 370565000671 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 370565000672 substrate binding site [chemical binding]; other site 370565000673 hexamer interface [polypeptide binding]; other site 370565000674 metal binding site [ion binding]; metal-binding site 370565000675 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 370565000676 Thiamine pyrophosphokinase; Region: TPK; cd07995 370565000677 active site 370565000678 dimerization interface [polypeptide binding]; other site 370565000679 thiamine binding site [chemical binding]; other site 370565000680 RmuC family; Region: RmuC; pfam02646 370565000681 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 370565000682 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 370565000683 generic binding surface II; other site 370565000684 generic binding surface I; other site 370565000685 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 370565000686 pur operon repressor; Provisional; Region: PRK09213 370565000687 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 370565000688 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 370565000689 active site 370565000690 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 370565000691 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 370565000692 S17 interaction site [polypeptide binding]; other site 370565000693 S8 interaction site; other site 370565000694 16S rRNA interaction site [nucleotide binding]; other site 370565000695 streptomycin interaction site [chemical binding]; other site 370565000696 23S rRNA interaction site [nucleotide binding]; other site 370565000697 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 370565000698 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 370565000699 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565000700 G1 box; other site 370565000701 GTP/Mg2+ binding site [chemical binding]; other site 370565000702 G2 box; other site 370565000703 Switch I region; other site 370565000704 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565000705 Switch II region; other site 370565000706 G4 box; other site 370565000707 G5 box; other site 370565000708 elongation factor EF-2; Reviewed; Region: PRK07560 370565000709 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 370565000710 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 370565000711 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 370565000712 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565000713 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 370565000714 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 370565000715 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 370565000716 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565000717 Walker A/P-loop; other site 370565000718 ATP binding site [chemical binding]; other site 370565000719 Q-loop/lid; other site 370565000720 ABC transporter signature motif; other site 370565000721 Walker B; other site 370565000722 D-loop; other site 370565000723 H-loop/switch region; other site 370565000724 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 370565000725 membrane-bound complex binding site; other site 370565000726 hinge residues; other site 370565000727 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 370565000728 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370565000729 dimer interface [polypeptide binding]; other site 370565000730 conserved gate region; other site 370565000731 putative PBP binding loops; other site 370565000732 ABC-ATPase subunit interface; other site 370565000733 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 370565000734 substrate binding pocket [chemical binding]; other site 370565000735 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 370565000736 Bacitracin resistance protein BacA; Region: BacA; cl00858 370565000737 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 370565000738 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 370565000739 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 370565000740 Mg++ binding site [ion binding]; other site 370565000741 putative catalytic motif [active] 370565000742 substrate binding site [chemical binding]; other site 370565000743 FeS assembly ATPase SufC; Region: sufC; TIGR01978 370565000744 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 370565000745 Walker A/P-loop; other site 370565000746 ATP binding site [chemical binding]; other site 370565000747 Q-loop/lid; other site 370565000748 ABC transporter signature motif; other site 370565000749 Walker B; other site 370565000750 D-loop; other site 370565000751 H-loop/switch region; other site 370565000752 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 370565000753 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 370565000754 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 370565000755 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 370565000756 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 370565000757 catalytic residue [active] 370565000758 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 370565000759 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 370565000760 trimerization site [polypeptide binding]; other site 370565000761 active site 370565000762 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 370565000763 FeS assembly protein SufB; Region: sufB; TIGR01980 370565000764 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 370565000765 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 370565000766 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 370565000767 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 370565000768 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 370565000769 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 370565000770 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 370565000771 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 370565000772 peptide binding site [polypeptide binding]; other site 370565000773 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 370565000774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370565000775 dimer interface [polypeptide binding]; other site 370565000776 conserved gate region; other site 370565000777 putative PBP binding loops; other site 370565000778 ABC-ATPase subunit interface; other site 370565000779 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 370565000780 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 370565000781 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370565000782 dimer interface [polypeptide binding]; other site 370565000783 conserved gate region; other site 370565000784 putative PBP binding loops; other site 370565000785 ABC-ATPase subunit interface; other site 370565000786 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 370565000787 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 370565000788 Walker A/P-loop; other site 370565000789 ATP binding site [chemical binding]; other site 370565000790 Q-loop/lid; other site 370565000791 ABC transporter signature motif; other site 370565000792 Walker B; other site 370565000793 D-loop; other site 370565000794 H-loop/switch region; other site 370565000795 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 370565000796 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 370565000797 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 370565000798 Walker A/P-loop; other site 370565000799 ATP binding site [chemical binding]; other site 370565000800 Q-loop/lid; other site 370565000801 ABC transporter signature motif; other site 370565000802 Walker B; other site 370565000803 D-loop; other site 370565000804 H-loop/switch region; other site 370565000805 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 370565000806 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 370565000807 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 370565000808 active site 370565000809 motif I; other site 370565000810 motif II; other site 370565000811 GTPase YqeH; Provisional; Region: PRK13796 370565000812 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 370565000813 GTP/Mg2+ binding site [chemical binding]; other site 370565000814 G4 box; other site 370565000815 G5 box; other site 370565000816 G1 box; other site 370565000817 Switch I region; other site 370565000818 G2 box; other site 370565000819 G3 box; other site 370565000820 Switch II region; other site 370565000821 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 370565000822 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 370565000823 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 370565000824 active site 370565000825 (T/H)XGH motif; other site 370565000826 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 370565000827 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 370565000828 Oligomerisation domain; Region: Oligomerisation; cl00519 370565000829 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 370565000830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370565000831 S-adenosylmethionine binding site [chemical binding]; other site 370565000832 hypothetical protein; Provisional; Region: PRK13670 370565000833 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 370565000834 Transcriptional regulator; Region: Transcrip_reg; cl00361 370565000835 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 370565000836 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 370565000837 substrate binding pocket [chemical binding]; other site 370565000838 membrane-bound complex binding site; other site 370565000839 hinge residues; other site 370565000840 NMT1-like family; Region: NMT1_2; cl15260 370565000841 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 370565000842 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 370565000843 Walker A/P-loop; other site 370565000844 ATP binding site [chemical binding]; other site 370565000845 Q-loop/lid; other site 370565000846 ABC transporter signature motif; other site 370565000847 Walker B; other site 370565000848 D-loop; other site 370565000849 H-loop/switch region; other site 370565000850 NIL domain; Region: NIL; cl09633 370565000851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 370565000852 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 370565000853 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 370565000854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565000855 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 370565000856 Cation transport protein; Region: TrkH; cl10514 370565000857 Methyltransferase domain; Region: Methyltransf_31; pfam13847 370565000858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370565000859 S-adenosylmethionine binding site [chemical binding]; other site 370565000860 LemA family; Region: LemA; cl00742 370565000861 Peptidase family M48; Region: Peptidase_M48; cl12018 370565000862 Peptidase family M48; Region: Peptidase_M48; cl12018 370565000863 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 370565000864 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 370565000865 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370565000866 active site 370565000867 phosphorylation site [posttranslational modification] 370565000868 intermolecular recognition site; other site 370565000869 dimerization interface [polypeptide binding]; other site 370565000870 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 370565000871 DNA binding site [nucleotide binding] 370565000872 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 370565000873 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 370565000874 dimerization interface [polypeptide binding]; other site 370565000875 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 370565000876 dimer interface [polypeptide binding]; other site 370565000877 phosphorylation site [posttranslational modification] 370565000878 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370565000879 ATP binding site [chemical binding]; other site 370565000880 Mg2+ binding site [ion binding]; other site 370565000881 G-X-G motif; other site 370565000882 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 370565000883 ATP cone domain; Region: ATP-cone; pfam03477 370565000884 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 370565000885 primosomal protein DnaI; Reviewed; Region: PRK08939 370565000886 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 370565000887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370565000888 Walker A motif; other site 370565000889 ATP binding site [chemical binding]; other site 370565000890 Walker B motif; other site 370565000891 GTP-binding protein Der; Reviewed; Region: PRK00093 370565000892 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 370565000893 G1 box; other site 370565000894 GTP/Mg2+ binding site [chemical binding]; other site 370565000895 Switch I region; other site 370565000896 G2 box; other site 370565000897 Switch II region; other site 370565000898 G3 box; other site 370565000899 G4 box; other site 370565000900 G5 box; other site 370565000901 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 370565000902 G1 box; other site 370565000903 GTP/Mg2+ binding site [chemical binding]; other site 370565000904 Switch I region; other site 370565000905 G2 box; other site 370565000906 G3 box; other site 370565000907 Switch II region; other site 370565000908 G4 box; other site 370565000909 G5 box; other site 370565000910 SWIM zinc finger; Region: SWIM; cl15408 370565000911 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 370565000912 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 370565000913 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 370565000914 ATP binding site [chemical binding]; other site 370565000915 putative Mg++ binding site [ion binding]; other site 370565000916 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 370565000917 nucleotide binding region [chemical binding]; other site 370565000918 ATP-binding site [chemical binding]; other site 370565000919 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 370565000920 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 370565000921 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 370565000922 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 370565000923 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 370565000924 YceG-like family; Region: YceG; pfam02618 370565000925 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 370565000926 dimerization interface [polypeptide binding]; other site 370565000927 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 370565000928 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 370565000929 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 370565000930 OxaA-like protein precursor; Provisional; Region: PRK02463 370565000931 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 370565000932 Acylphosphatase; Region: Acylphosphatase; cl00551 370565000933 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 370565000934 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 370565000935 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 370565000936 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 370565000937 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 370565000938 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 370565000939 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 370565000940 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 370565000941 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 370565000942 active site 370565000943 dimerization interface [polypeptide binding]; other site 370565000944 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 370565000945 active site 370565000946 metal binding site [ion binding]; metal-binding site 370565000947 homotetramer interface [polypeptide binding]; other site 370565000948 FOG: CBS domain [General function prediction only]; Region: COG0517 370565000949 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 370565000950 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 370565000951 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 370565000952 DNA binding site [nucleotide binding] 370565000953 Int/Topo IB signature motif; other site 370565000954 active site 370565000955 catalytic residues [active] 370565000956 ScpA/B protein; Region: ScpA_ScpB; cl00598 370565000957 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 370565000958 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 370565000959 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 370565000960 RNA binding surface [nucleotide binding]; other site 370565000961 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 370565000962 active site 370565000963 Haemolytic domain; Region: Haemolytic; cl00506 370565000964 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 370565000965 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 370565000966 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 370565000967 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 370565000968 active site 370565000969 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 370565000970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 370565000971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 370565000972 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 370565000973 Domain of unknown function DUF21; Region: DUF21; pfam01595 370565000974 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 370565000975 Transporter associated domain; Region: CorC_HlyC; cl08393 370565000976 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 370565000977 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370565000978 FeS/SAM binding site; other site 370565000979 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 370565000980 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 370565000981 DHHA2 domain; Region: DHHA2; pfam02833 370565000982 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 370565000983 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 370565000984 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 370565000985 ABC-ATPase subunit interface; other site 370565000986 dimer interface [polypeptide binding]; other site 370565000987 putative PBP binding regions; other site 370565000988 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 370565000989 ABC-ATPase subunit interface; other site 370565000990 dimer interface [polypeptide binding]; other site 370565000991 putative PBP binding regions; other site 370565000992 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 370565000993 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 370565000994 putative ligand binding residues [chemical binding]; other site 370565000995 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 370565000996 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 370565000997 Walker A/P-loop; other site 370565000998 ATP binding site [chemical binding]; other site 370565000999 Q-loop/lid; other site 370565001000 ABC transporter signature motif; other site 370565001001 Walker B; other site 370565001002 D-loop; other site 370565001003 H-loop/switch region; other site 370565001004 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 370565001005 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 370565001006 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 370565001007 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 370565001008 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 370565001009 MatE; Region: MatE; cl10513 370565001010 MviN-like protein; Region: MVIN; pfam03023 370565001011 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 370565001012 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 370565001013 active site 370565001014 Clp protease; Region: CLP_protease; pfam00574 370565001015 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 370565001016 oligomer interface [polypeptide binding]; other site 370565001017 active site residues [active] 370565001018 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 370565001019 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 370565001020 Transposase [DNA replication, recombination, and repair]; Region: COG5433 370565001021 thymidylate kinase; Validated; Region: tmk; PRK00698 370565001022 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 370565001023 TMP-binding site; other site 370565001024 ATP-binding site [chemical binding]; other site 370565001025 DNA polymerase III subunit delta'; Validated; Region: PRK07276 370565001026 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565001027 PSP1 C-terminal conserved region; Region: PSP1; cl00770 370565001028 TSC-22/dip/bun family; Region: TSC22; cl01853 370565001029 Predicted methyltransferases [General function prediction only]; Region: COG0313 370565001030 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 370565001031 CutC family; Region: CutC; cl01218 370565001032 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 370565001033 ArsC family; Region: ArsC; pfam03960 370565001034 putative ArsC-like catalytic residues; other site 370565001035 putative TRX-like catalytic residues [active] 370565001036 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 370565001037 active site 370565001038 putative catalytic site [active] 370565001039 DNA binding site [nucleotide binding] 370565001040 putative phosphate binding site [ion binding]; other site 370565001041 metal binding site A [ion binding]; metal-binding site 370565001042 AP binding site [nucleotide binding]; other site 370565001043 metal binding site B [ion binding]; metal-binding site 370565001044 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 370565001045 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 370565001046 teramer interface [polypeptide binding]; other site 370565001047 active site 370565001048 FMN binding site [chemical binding]; other site 370565001049 catalytic residues [active] 370565001050 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 370565001051 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 370565001052 putative active site [active] 370565001053 catalytic triad [active] 370565001054 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 370565001055 putative integrin binding motif; other site 370565001056 PA/protease domain interface [polypeptide binding]; other site 370565001057 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 370565001058 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 370565001059 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 370565001060 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 370565001061 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 370565001062 active site 370565001063 HIGH motif; other site 370565001064 KMSKS motif; other site 370565001065 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 370565001066 tRNA binding surface [nucleotide binding]; other site 370565001067 anticodon binding site; other site 370565001068 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 370565001069 dimer interface [polypeptide binding]; other site 370565001070 putative tRNA-binding site [nucleotide binding]; other site 370565001071 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 370565001072 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 370565001073 dimer interface [polypeptide binding]; other site 370565001074 putative radical transfer pathway; other site 370565001075 diiron center [ion binding]; other site 370565001076 tyrosyl radical; other site 370565001077 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 370565001078 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187 370565001079 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 370565001080 Class I ribonucleotide reductase; Region: RNR_I; cd01679 370565001081 active site 370565001082 dimer interface [polypeptide binding]; other site 370565001083 catalytic residues [active] 370565001084 effector binding site; other site 370565001085 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 370565001086 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cd00233 370565001087 active site 370565001088 conformational flexibility of ligand binding pocket; other site 370565001089 ADP-ribosylating toxin turn-turn motif; other site 370565001090 flagellar assembly protein H; Validated; Region: fliH; PRK05687 370565001091 Protein of unknown function (DUF3644); Region: DUF3644; pfam12358 370565001092 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 370565001093 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 370565001094 classical (c) SDRs; Region: SDR_c; cd05233 370565001095 NAD(P) binding site [chemical binding]; other site 370565001096 active site 370565001097 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 370565001098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565001099 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 370565001100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370565001101 putative substrate translocation pore; other site 370565001102 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: Arch_glmU; TIGR03992 370565001103 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 370565001104 Substrate binding site; other site 370565001105 Mg++ binding site; other site 370565001106 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 370565001107 active site 370565001108 substrate binding site [chemical binding]; other site 370565001109 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 370565001110 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 370565001111 dimer interface [polypeptide binding]; other site 370565001112 ADP-ribose binding site [chemical binding]; other site 370565001113 active site 370565001114 nudix motif; other site 370565001115 metal binding site [ion binding]; metal-binding site 370565001116 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 370565001117 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 370565001118 FeoA domain; Region: FeoA; cl00838 370565001119 Helix-turn-helix domains; Region: HTH; cl00088 370565001120 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 370565001121 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 370565001122 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 370565001123 metal binding site [ion binding]; metal-binding site 370565001124 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 370565001125 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 370565001126 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 370565001127 ABC-ATPase subunit interface; other site 370565001128 dimer interface [polypeptide binding]; other site 370565001129 putative PBP binding regions; other site 370565001130 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 370565001131 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 370565001132 active site 370565001133 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 370565001134 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565001135 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 370565001136 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 370565001137 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 370565001138 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 370565001139 23S rRNA interface [nucleotide binding]; other site 370565001140 L7/L12 interface [polypeptide binding]; other site 370565001141 putative thiostrepton binding site; other site 370565001142 L25 interface [polypeptide binding]; other site 370565001143 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 370565001144 mRNA/rRNA interface [nucleotide binding]; other site 370565001145 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 370565001146 putative nucleotide binding site [chemical binding]; other site 370565001147 uridine monophosphate binding site [chemical binding]; other site 370565001148 homohexameric interface [polypeptide binding]; other site 370565001149 ribosome recycling factor; Reviewed; Region: frr; PRK00083 370565001150 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 370565001151 hinge region; other site 370565001152 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 370565001153 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 370565001154 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 370565001155 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 370565001156 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 370565001157 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 370565001158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565001159 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565001160 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 370565001161 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565001162 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565001163 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 370565001164 putative uracil binding site [chemical binding]; other site 370565001165 putative active site [active] 370565001166 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 370565001167 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 370565001168 GTPase Era; Reviewed; Region: era; PRK00089 370565001169 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 370565001170 G1 box; other site 370565001171 GTP/Mg2+ binding site [chemical binding]; other site 370565001172 Switch I region; other site 370565001173 G2 box; other site 370565001174 Switch II region; other site 370565001175 G3 box; other site 370565001176 G4 box; other site 370565001177 G5 box; other site 370565001178 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 370565001179 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 370565001180 nudix motif; other site 370565001181 Transposase, Mutator family; Region: Transposase_mut; pfam00872 370565001182 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 370565001183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370565001184 non-specific DNA binding site [nucleotide binding]; other site 370565001185 salt bridge; other site 370565001186 sequence-specific DNA binding site [nucleotide binding]; other site 370565001187 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 370565001188 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 370565001189 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 370565001190 DNA binding site [nucleotide binding] 370565001191 catalytic residue [active] 370565001192 H2TH interface [polypeptide binding]; other site 370565001193 putative catalytic residues [active] 370565001194 turnover-facilitating residue; other site 370565001195 intercalation triad [nucleotide binding]; other site 370565001196 8OG recognition residue [nucleotide binding]; other site 370565001197 putative reading head residues; other site 370565001198 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 370565001199 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 370565001200 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 370565001201 CoA-binding site [chemical binding]; other site 370565001202 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 370565001203 Domain of unknown function DUF87; Region: DUF87; pfam01935 370565001204 drug efflux system protein MdtG; Provisional; Region: PRK09874 370565001205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370565001206 putative substrate translocation pore; other site 370565001207 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 370565001208 Preprotein translocase SecG subunit; Region: SecG; cl09123 370565001209 ribonuclease R; Region: RNase_R; TIGR02063 370565001210 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 370565001211 RNB domain; Region: RNB; pfam00773 370565001212 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 370565001213 RNA binding site [nucleotide binding]; other site 370565001214 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 370565001215 SmpB-tmRNA interface; other site 370565001216 Glutamine cyclotransferase; Region: Glu_cyclase_2; pfam05096 370565001217 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 370565001218 putative substrate binding pocket [chemical binding]; other site 370565001219 AC domain interface; other site 370565001220 catalytic triad [active] 370565001221 AB domain interface; other site 370565001222 interchain disulfide; other site 370565001223 Protein of unknown function (DUF979); Region: DUF979; cl01572 370565001224 Protein of unknown function (DUF969); Region: DUF969; cl01573 370565001225 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 370565001226 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 370565001227 Ligand binding site; other site 370565001228 Putative Catalytic site; other site 370565001229 DXD motif; other site 370565001230 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 370565001231 dimer interface [polypeptide binding]; other site 370565001232 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 370565001233 active site 370565001234 metal binding site [ion binding]; metal-binding site 370565001235 glutathione binding site [chemical binding]; other site 370565001236 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 370565001237 dimer interface [polypeptide binding]; other site 370565001238 FMN binding site [chemical binding]; other site 370565001239 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 370565001240 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 370565001241 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 370565001242 active site 370565001243 catabolite control protein A; Region: ccpA; TIGR01481 370565001244 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 370565001245 DNA binding site [nucleotide binding] 370565001246 domain linker motif; other site 370565001247 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 370565001248 dimerization interface [polypeptide binding]; other site 370565001249 effector binding site; other site 370565001250 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 370565001251 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 370565001252 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 370565001253 putative ADP-binding pocket [chemical binding]; other site 370565001254 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 370565001255 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 370565001256 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 370565001257 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 370565001258 active site 370565001259 dimer interface [polypeptide binding]; other site 370565001260 motif 1; other site 370565001261 motif 2; other site 370565001262 motif 3; other site 370565001263 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 370565001264 anticodon binding site; other site 370565001265 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 370565001266 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565001267 Walker A/P-loop; other site 370565001268 ATP binding site [chemical binding]; other site 370565001269 Q-loop/lid; other site 370565001270 ABC transporter signature motif; other site 370565001271 Walker B; other site 370565001272 D-loop; other site 370565001273 H-loop/switch region; other site 370565001274 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 370565001275 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 370565001276 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 370565001277 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 370565001278 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 370565001279 dimer interface [polypeptide binding]; other site 370565001280 active site 370565001281 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 370565001282 AMP-binding enzyme; Region: AMP-binding; cl15778 370565001283 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 370565001284 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 370565001285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370565001286 active site 370565001287 phosphorylation site [posttranslational modification] 370565001288 intermolecular recognition site; other site 370565001289 dimerization interface [polypeptide binding]; other site 370565001290 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 370565001291 DNA binding site [nucleotide binding] 370565001292 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 370565001293 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 370565001294 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 370565001295 dimer interface [polypeptide binding]; other site 370565001296 phosphorylation site [posttranslational modification] 370565001297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370565001298 ATP binding site [chemical binding]; other site 370565001299 Mg2+ binding site [ion binding]; other site 370565001300 G-X-G motif; other site 370565001301 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370565001302 ribonuclease III; Reviewed; Region: rnc; PRK00102 370565001303 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 370565001304 dimerization interface [polypeptide binding]; other site 370565001305 active site 370565001306 metal binding site [ion binding]; metal-binding site 370565001307 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 370565001308 dsRNA binding site [nucleotide binding]; other site 370565001309 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 370565001310 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 370565001311 Walker A/P-loop; other site 370565001312 ATP binding site [chemical binding]; other site 370565001313 Q-loop/lid; other site 370565001314 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 370565001315 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 370565001316 ABC transporter signature motif; other site 370565001317 Walker B; other site 370565001318 D-loop; other site 370565001319 H-loop/switch region; other site 370565001320 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370565001321 non-specific DNA binding site [nucleotide binding]; other site 370565001322 salt bridge; other site 370565001323 sequence-specific DNA binding site [nucleotide binding]; other site 370565001324 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 370565001325 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 370565001326 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 370565001327 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 370565001328 shikimate binding site; other site 370565001329 NAD(P) binding site [chemical binding]; other site 370565001330 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 370565001331 GTP and metal dependent enzyme involved F420 coenzyme biosynthesis (catalyzes addition of two l-glutamates to F420 precursor) [Coenzyme transport and metabolism]; Region: COG1478 370565001332 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 370565001333 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 370565001334 Archaeal S-adenosylmethionine synthetase [Amino acid transport and metabolism]; Region: MetK; COG1812 370565001335 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 370565001336 active site 370565001337 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 370565001338 active site 370565001339 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 370565001340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565001341 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 370565001342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565001343 Ferroportin1 (FPN1); Region: FPN1; pfam06963 370565001344 H+ Antiporter protein; Region: 2A0121; TIGR00900 370565001345 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 370565001346 RelB antitoxin; Region: RelB; cl01171 370565001347 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 370565001348 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 370565001349 active site 370565001350 motif 3; other site 370565001351 HTH-like domain; Region: HTH_21; pfam13276 370565001352 Integrase core domain; Region: rve; cl01316 370565001353 Helix-turn-helix domains; Region: HTH; cl00088 370565001354 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 370565001355 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 370565001356 active site 370565001357 motif I; other site 370565001358 motif II; other site 370565001359 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 370565001360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 370565001361 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 370565001362 active site 370565001363 motif I; other site 370565001364 motif II; other site 370565001365 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 370565001366 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 370565001367 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 370565001368 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 370565001369 P loop; other site 370565001370 GTP binding site [chemical binding]; other site 370565001371 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 370565001372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370565001373 putative substrate translocation pore; other site 370565001374 transcriptional antiterminator BglG; Provisional; Region: PRK09772 370565001375 CAT RNA binding domain; Region: CAT_RBD; cl03904 370565001376 PRD domain; Region: PRD; cl15445 370565001377 PRD domain; Region: PRD; cl15445 370565001378 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 370565001379 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 370565001380 active site turn [active] 370565001381 phosphorylation site [posttranslational modification] 370565001382 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 370565001383 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 370565001384 HPr interaction site; other site 370565001385 glycerol kinase (GK) interaction site [polypeptide binding]; other site 370565001386 active site 370565001387 phosphorylation site [posttranslational modification] 370565001388 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 370565001389 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 370565001390 Predicted permeases [General function prediction only]; Region: COG0701 370565001391 Predicted permease; Region: DUF318; pfam03773 370565001392 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 370565001393 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 370565001394 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 370565001395 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 370565001396 RNA binding site [nucleotide binding]; other site 370565001397 SprT homologues; Region: SprT; cl01182 370565001398 hypothetical protein; Provisional; Region: PRK04351 370565001399 PspC domain; Region: PspC; cl00864 370565001400 HPr kinase/phosphorylase; Provisional; Region: PRK05428 370565001401 DRTGG domain; Region: DRTGG; cl12147 370565001402 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 370565001403 Hpr binding site; other site 370565001404 active site 370565001405 homohexamer subunit interaction site [polypeptide binding]; other site 370565001406 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 370565001407 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 370565001408 YtxH-like protein; Region: YtxH; cl02079 370565001409 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 370565001410 coenzyme PQQ biosynthesis enzyme PqqE; Region: PQQ_syn_pqqE; TIGR02109 370565001411 Peptidase family U32; Region: Peptidase_U32; cl03113 370565001412 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 370565001413 Peptidase family U32; Region: Peptidase_U32; cl03113 370565001414 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; cl01839 370565001415 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 370565001416 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 370565001417 dimer interface [polypeptide binding]; other site 370565001418 putative anticodon binding site; other site 370565001419 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 370565001420 motif 1; other site 370565001421 active site 370565001422 motif 2; other site 370565001423 motif 3; other site 370565001424 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 370565001425 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 370565001426 motif II; other site 370565001427 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 370565001428 catalytic core [active] 370565001429 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 370565001430 putative deacylase active site [active] 370565001431 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 370565001432 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 370565001433 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 370565001434 active site 370565001435 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 370565001436 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 370565001437 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 370565001438 catalytic residues [active] 370565001439 dimer interface [polypeptide binding]; other site 370565001440 oligoendopeptidase F; Region: pepF; TIGR00181 370565001441 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 370565001442 Zn binding site [ion binding]; other site 370565001443 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 370565001444 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 370565001445 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 370565001446 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565001447 G1 box; other site 370565001448 GTP/Mg2+ binding site [chemical binding]; other site 370565001449 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565001450 G2 box; other site 370565001451 Switch I region; other site 370565001452 G3 box; other site 370565001453 Switch II region; other site 370565001454 GTP/Mg2+ binding site [chemical binding]; other site 370565001455 G4 box; other site 370565001456 G5 box; other site 370565001457 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 370565001458 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 370565001459 Antibiotic Binding Site [chemical binding]; other site 370565001460 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 370565001461 substrate binding site [chemical binding]; other site 370565001462 dimer interface [polypeptide binding]; other site 370565001463 catalytic triad [active] 370565001464 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 370565001465 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 370565001466 sugar phosphate phosphatase; Provisional; Region: PRK10513 370565001467 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 370565001468 motif II; other site 370565001469 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 370565001470 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 370565001471 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 370565001472 Zn2+ binding site [ion binding]; other site 370565001473 Mg2+ binding site [ion binding]; other site 370565001474 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 370565001475 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 370565001476 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 370565001477 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 370565001478 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 370565001479 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 370565001480 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 370565001481 Transcriptional regulators [Transcription]; Region: PurR; COG1609 370565001482 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 370565001483 DNA binding site [nucleotide binding] 370565001484 domain linker motif; other site 370565001485 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 370565001486 putative dimerization interface [polypeptide binding]; other site 370565001487 putative ligand binding site [chemical binding]; other site 370565001488 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 370565001489 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 370565001490 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 370565001491 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 370565001492 active site 370565001493 phosphorylation site [posttranslational modification] 370565001494 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 370565001495 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 370565001496 active pocket/dimerization site; other site 370565001497 active site 370565001498 phosphorylation site [posttranslational modification] 370565001499 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 370565001500 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 370565001501 NADP binding site [chemical binding]; other site 370565001502 homodimer interface [polypeptide binding]; other site 370565001503 active site 370565001504 hypothetical protein; Provisional; Region: PRK09273 370565001505 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 370565001506 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 370565001507 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 370565001508 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 370565001509 substrate binding site [chemical binding]; other site 370565001510 ATP binding site [chemical binding]; other site 370565001511 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 370565001512 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 370565001513 active site 370565001514 intersubunit interface [polypeptide binding]; other site 370565001515 catalytic residue [active] 370565001516 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 370565001517 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 370565001518 motif II; other site 370565001519 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 370565001520 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 370565001521 peptide chain release factor 2; Validated; Region: prfB; PRK00578 370565001522 RF-1 domain; Region: RF-1; cl02875 370565001523 RF-1 domain; Region: RF-1; cl02875 370565001524 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 370565001525 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565001526 Walker A/P-loop; other site 370565001527 ATP binding site [chemical binding]; other site 370565001528 Q-loop/lid; other site 370565001529 ABC transporter signature motif; other site 370565001530 Walker B; other site 370565001531 D-loop; other site 370565001532 H-loop/switch region; other site 370565001533 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 370565001534 FtsX-like permease family; Region: FtsX; cl15850 370565001535 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370565001536 acetoin reductase; Validated; Region: PRK08643 370565001537 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 370565001538 NAD binding site [chemical binding]; other site 370565001539 homotetramer interface [polypeptide binding]; other site 370565001540 homodimer interface [polypeptide binding]; other site 370565001541 active site 370565001542 substrate binding site [chemical binding]; other site 370565001543 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 370565001544 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 370565001545 active site 370565001546 catalytic site [active] 370565001547 substrate binding site [chemical binding]; other site 370565001548 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565001549 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565001550 aspartate aminotransferase; Provisional; Region: PRK05764 370565001551 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 370565001552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370565001553 homodimer interface [polypeptide binding]; other site 370565001554 catalytic residue [active] 370565001555 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 370565001556 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 370565001557 putative dimer interface [polypeptide binding]; other site 370565001558 putative anticodon binding site; other site 370565001559 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 370565001560 homodimer interface [polypeptide binding]; other site 370565001561 motif 1; other site 370565001562 motif 2; other site 370565001563 active site 370565001564 motif 3; other site 370565001565 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 370565001566 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 370565001567 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 370565001568 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 370565001569 dimer interface [polypeptide binding]; other site 370565001570 phosphate binding site [ion binding]; other site 370565001571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 370565001572 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 370565001573 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 370565001574 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 370565001575 catalytic residues [active] 370565001576 catalytic nucleophile [active] 370565001577 Presynaptic Site I dimer interface [polypeptide binding]; other site 370565001578 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 370565001579 Synaptic Flat tetramer interface [polypeptide binding]; other site 370565001580 Synaptic Site I dimer interface [polypeptide binding]; other site 370565001581 DNA binding site [nucleotide binding] 370565001582 Recombinase; Region: Recombinase; pfam07508 370565001583 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 370565001584 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370565001585 non-specific DNA binding site [nucleotide binding]; other site 370565001586 salt bridge; other site 370565001587 sequence-specific DNA binding site [nucleotide binding]; other site 370565001588 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 370565001589 Catalytic site [active] 370565001590 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370565001591 non-specific DNA binding site [nucleotide binding]; other site 370565001592 salt bridge; other site 370565001593 sequence-specific DNA binding site [nucleotide binding]; other site 370565001594 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565001595 AAA domain; Region: AAA_23; pfam13476 370565001596 Walker A/P-loop; other site 370565001597 ATP binding site [chemical binding]; other site 370565001598 AAA domain; Region: AAA_24; pfam13479 370565001599 phage nucleotide-binding protein; Region: phage_P_loop; TIGR01618 370565001600 DEAD-like helicases superfamily; Region: DEXDc; smart00487 370565001601 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 370565001602 ATP binding site [chemical binding]; other site 370565001603 putative Mg++ binding site [ion binding]; other site 370565001604 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 370565001605 nucleotide binding region [chemical binding]; other site 370565001606 ATP-binding site [chemical binding]; other site 370565001607 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 370565001608 RecA-family ATPase [DNA replication, recombination, and repair]; Region: RepA; COG3598 370565001609 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565001610 Walker A motif; other site 370565001611 ATP binding site [chemical binding]; other site 370565001612 Walker B motif; other site 370565001613 Endodeoxyribonuclease RusA; Region: RusA; cl01885 370565001614 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 370565001615 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 370565001616 ParB-like nuclease domain; Region: ParBc; cl02129 370565001617 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 370565001618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 370565001619 Phage terminase large subunit; Region: Terminase_3; cl12054 370565001620 Terminase-like family; Region: Terminase_6; pfam03237 370565001621 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 370565001622 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 370565001623 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 370565001624 Phage capsid family; Region: Phage_capsid; pfam05065 370565001625 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 370565001626 Minor capsid protein; Region: Minor_capsid_1; pfam10665 370565001627 Minor capsid protein; Region: Minor_capsid_2; pfam11114 370565001628 Minor capsid protein from bacteriophage; Region: Minor_capsid_3; pfam12691 370565001629 Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854 370565001630 tape measure domain; Region: tape_meas_nterm; TIGR02675 370565001631 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 370565001632 Phage-related protein [Function unknown]; Region: COG4722; cl15832 370565001633 Phage tail protein; Region: Sipho_tail; pfam05709 370565001634 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 370565001635 gp58-like protein; Region: Gp58; pfam07902 370565001636 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 370565001637 NlpC/P60 family; Region: NLPC_P60; cl11438 370565001638 Bacterial SH3 domain; Region: SH3_3; cl02551 370565001639 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 370565001640 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 370565001641 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 370565001642 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 370565001643 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 370565001644 Peptidase family C69; Region: Peptidase_C69; pfam03577 370565001645 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 370565001646 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 370565001647 metal binding site [ion binding]; metal-binding site 370565001648 YodA lipocalin-like domain; Region: YodA; cl01365 370565001649 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 370565001650 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 370565001651 DNA-binding site [nucleotide binding]; DNA binding site 370565001652 UTRA domain; Region: UTRA; cl01230 370565001653 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 370565001654 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 370565001655 dimer interface [polypeptide binding]; other site 370565001656 active site 370565001657 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 370565001658 putative active site [active] 370565001659 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 370565001660 DHH family; Region: DHH; pfam01368 370565001661 DHHA1 domain; Region: DHHA1; pfam02272 370565001662 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 370565001663 Chorismate mutase type II; Region: CM_2; cl00693 370565001664 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 370565001665 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 370565001666 Cl- selectivity filter; other site 370565001667 Cl- binding residues [ion binding]; other site 370565001668 pore gating glutamate residue; other site 370565001669 dimer interface [polypeptide binding]; other site 370565001670 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 370565001671 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370565001672 DNA binding site [nucleotide binding] 370565001673 active site 370565001674 Int/Topo IB signature motif; other site 370565001675 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 370565001676 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 370565001677 motif II; other site 370565001678 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 370565001679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 370565001680 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 370565001681 anchoring element; other site 370565001682 dimer interface [polypeptide binding]; other site 370565001683 ATP binding site [chemical binding]; other site 370565001684 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 370565001685 active site 370565001686 putative metal-binding site [ion binding]; other site 370565001687 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 370565001688 septation ring formation regulator EzrA; Provisional; Region: PRK04778 370565001689 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 370565001690 enolase; Provisional; Region: eno; PRK00077 370565001691 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 370565001692 dimer interface [polypeptide binding]; other site 370565001693 metal binding site [ion binding]; metal-binding site 370565001694 substrate binding pocket [chemical binding]; other site 370565001695 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 370565001696 Transposase; Region: DEDD_Tnp_IS110; pfam01548 370565001697 MAEBL; Provisional; Region: PTZ00121 370565001698 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 370565001699 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 370565001700 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 370565001701 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 370565001702 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 370565001703 bacteriocin protoxin, streptolysin S family; Region: streptolysinS; TIGR03602 370565001704 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 370565001705 putative FMN binding site [chemical binding]; other site 370565001706 NADPH bind site [chemical binding]; other site 370565001707 bacteriocin biosynthesis cyclodehydratase, SagC family; Region: cyclo_dehy_ocin; TIGR03603 370565001708 bacteriocin biosynthesis docking scaffold, SagD family; Region: docking_ocin; cl09146 370565001709 YcaO-like family; Region: YcaO; pfam02624 370565001710 CAAX protease self-immunity; Region: Abi; cl00558 370565001711 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 370565001712 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565001713 Walker A/P-loop; other site 370565001714 ATP binding site [chemical binding]; other site 370565001715 Q-loop/lid; other site 370565001716 ABC transporter signature motif; other site 370565001717 Walker B; other site 370565001718 D-loop; other site 370565001719 H-loop/switch region; other site 370565001720 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 370565001721 ABC-2 type transporter; Region: ABC2_membrane; cl11417 370565001722 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 370565001723 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 370565001724 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 370565001725 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 370565001726 generic binding surface II; other site 370565001727 generic binding surface I; other site 370565001728 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 370565001729 generic binding surface II; other site 370565001730 generic binding surface I; other site 370565001731 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 370565001732 putative catalytic site [active] 370565001733 putative metal binding site [ion binding]; other site 370565001734 putative phosphate binding site [ion binding]; other site 370565001735 QueT transporter; Region: QueT; cl01932 370565001736 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 370565001737 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 370565001738 nucleotide binding pocket [chemical binding]; other site 370565001739 K-X-D-G motif; other site 370565001740 catalytic site [active] 370565001741 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 370565001742 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 370565001743 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 370565001744 Dimer interface [polypeptide binding]; other site 370565001745 BRCT sequence motif; other site 370565001746 putative lipid kinase; Reviewed; Region: PRK13055 370565001747 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 370565001748 ATP synthase subunit C; Region: ATP-synt_C; cl00466 370565001749 ATP synthase A chain; Region: ATP-synt_A; cl00413 370565001750 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 370565001751 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 370565001752 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 370565001753 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 370565001754 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 370565001755 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 370565001756 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 370565001757 beta subunit interaction interface [polypeptide binding]; other site 370565001758 Walker A motif; other site 370565001759 ATP binding site [chemical binding]; other site 370565001760 Walker B motif; other site 370565001761 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 370565001762 ATP synthase; Region: ATP-synt; cl00365 370565001763 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 370565001764 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 370565001765 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 370565001766 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 370565001767 alpha subunit interaction interface [polypeptide binding]; other site 370565001768 Walker A motif; other site 370565001769 ATP binding site [chemical binding]; other site 370565001770 Walker B motif; other site 370565001771 inhibitor binding site; inhibition site 370565001772 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 370565001773 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 370565001774 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 370565001775 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 370565001776 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 370565001777 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 370565001778 hinge; other site 370565001779 active site 370565001780 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 370565001781 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 370565001782 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 370565001783 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 370565001784 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 370565001785 dimer interface [polypeptide binding]; other site 370565001786 motif 1; other site 370565001787 active site 370565001788 motif 2; other site 370565001789 motif 3; other site 370565001790 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 370565001791 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 370565001792 putative tRNA-binding site [nucleotide binding]; other site 370565001793 B3/4 domain; Region: B3_4; cl11458 370565001794 tRNA synthetase B5 domain; Region: B5; cl08394 370565001795 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 370565001796 dimer interface [polypeptide binding]; other site 370565001797 motif 1; other site 370565001798 motif 3; other site 370565001799 motif 2; other site 370565001800 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 370565001801 OsmC-like protein; Region: OsmC; cl00767 370565001802 Protein of unknown function (DUF1722); Region: DUF1722; cl01284 370565001803 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 370565001804 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 370565001805 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 370565001806 Walker A/P-loop; other site 370565001807 ATP binding site [chemical binding]; other site 370565001808 Q-loop/lid; other site 370565001809 ABC transporter signature motif; other site 370565001810 Walker B; other site 370565001811 D-loop; other site 370565001812 H-loop/switch region; other site 370565001813 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 370565001814 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 370565001815 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 370565001816 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 370565001817 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565001818 Family description; Region: UvrD_C_2; cl15862 370565001819 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 370565001820 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 370565001821 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 370565001822 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 370565001823 substrate binding pocket [chemical binding]; other site 370565001824 membrane-bound complex binding site; other site 370565001825 hinge residues; other site 370565001826 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 370565001827 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 370565001828 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 370565001829 DNA primase; Validated; Region: dnaG; PRK05667 370565001830 CHC2 zinc finger; Region: zf-CHC2; cl15369 370565001831 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 370565001832 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 370565001833 active site 370565001834 metal binding site [ion binding]; metal-binding site 370565001835 interdomain interaction site; other site 370565001836 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 370565001837 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 370565001838 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 370565001839 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 370565001840 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 370565001841 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 370565001842 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 370565001843 DNA binding residues [nucleotide binding] 370565001844 Domain of unknown function DUF59; Region: DUF59; cl00941 370565001845 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 370565001846 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 370565001847 NADP binding site [chemical binding]; other site 370565001848 active site 370565001849 putative substrate binding site [chemical binding]; other site 370565001850 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 370565001851 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 370565001852 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 370565001853 Probable Catalytic site; other site 370565001854 ABC-2 type transporter; Region: ABC2_membrane; cl11417 370565001855 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 370565001856 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 370565001857 Walker A/P-loop; other site 370565001858 ATP binding site [chemical binding]; other site 370565001859 Q-loop/lid; other site 370565001860 ABC transporter signature motif; other site 370565001861 Walker B; other site 370565001862 D-loop; other site 370565001863 H-loop/switch region; other site 370565001864 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 370565001865 active site 370565001866 Glycoside hydrolase families 71, 99, and related domains; Region: GH99_GH71_like; cl01529 370565001867 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 370565001868 Sulfatase; Region: Sulfatase; cl10460 370565001869 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 370565001870 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 370565001871 Ligand binding site; other site 370565001872 Putative Catalytic site; other site 370565001873 DXD motif; other site 370565001874 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 370565001875 MatE; Region: MatE; cl10513 370565001876 Predicted membrane protein [Function unknown]; Region: COG4713 370565001877 peptidase T; Region: peptidase-T; TIGR01882 370565001878 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 370565001879 metal binding site [ion binding]; metal-binding site 370565001880 dimer interface [polypeptide binding]; other site 370565001881 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 370565001882 cytidylate kinase; Provisional; Region: cmk; PRK00023 370565001883 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 370565001884 CMP-binding site; other site 370565001885 The sites determining sugar specificity; other site 370565001886 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 370565001887 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 370565001888 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 370565001889 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 370565001890 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 370565001891 23S rRNA binding site [nucleotide binding]; other site 370565001892 L21 binding site [polypeptide binding]; other site 370565001893 L13 binding site [polypeptide binding]; other site 370565001894 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 370565001895 Sulfatase; Region: Sulfatase; cl10460 370565001896 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 370565001897 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 370565001898 putative RNA binding site [nucleotide binding]; other site 370565001899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 370565001900 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 370565001901 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 370565001902 active site 370565001903 catalytic residue [active] 370565001904 dimer interface [polypeptide binding]; other site 370565001905 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 370565001906 Tetramer interface [polypeptide binding]; other site 370565001907 active site 370565001908 FMN-binding site [chemical binding]; other site 370565001909 Protein of unknown function (DUF964); Region: DUF964; cl01483 370565001910 glutathione reductase; Validated; Region: PRK06116 370565001911 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 370565001912 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 370565001913 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 370565001914 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 370565001915 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 370565001916 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 370565001917 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 370565001918 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 370565001919 catalytic residue [active] 370565001920 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 370565001921 THUMP domain; Region: THUMP; cl12076 370565001922 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 370565001923 Ligand Binding Site [chemical binding]; other site 370565001924 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 370565001925 putative active site [active] 370565001926 putative metal binding site [ion binding]; other site 370565001927 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 370565001928 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 370565001929 Protein of unknown function (DUF464); Region: DUF464; cl01080 370565001930 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 370565001931 Transcriptional regulator [Transcription]; Region: LysR; COG0583 370565001932 Helix-turn-helix domains; Region: HTH; cl00088 370565001933 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 370565001934 dimerization interface [polypeptide binding]; other site 370565001935 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 370565001936 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 370565001937 RNA binding surface [nucleotide binding]; other site 370565001938 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 370565001939 active site 370565001940 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 370565001941 active site 370565001942 uracil transporter; Provisional; Region: PRK10720 370565001943 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 370565001944 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 370565001945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565001946 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 370565001947 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 370565001948 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 370565001949 catalytic site [active] 370565001950 subunit interface [polypeptide binding]; other site 370565001951 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 370565001952 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 370565001953 ATP-grasp domain; Region: ATP-grasp_4; cl03087 370565001954 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 370565001955 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 370565001956 ATP-grasp domain; Region: ATP-grasp_4; cl03087 370565001957 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 370565001958 IMP binding site; other site 370565001959 dimer interface [polypeptide binding]; other site 370565001960 interdomain contacts; other site 370565001961 partial ornithine binding site; other site 370565001962 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 370565001963 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 370565001964 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 370565001965 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 370565001966 Walker A/P-loop; other site 370565001967 ATP binding site [chemical binding]; other site 370565001968 Q-loop/lid; other site 370565001969 ABC transporter signature motif; other site 370565001970 Walker B; other site 370565001971 D-loop; other site 370565001972 H-loop/switch region; other site 370565001973 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 370565001974 FtsX-like permease family; Region: FtsX; cl15850 370565001975 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 370565001976 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 370565001977 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 370565001978 putative active site [active] 370565001979 catalytic site [active] 370565001980 putative metal binding site [ion binding]; other site 370565001981 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 370565001982 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 370565001983 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 370565001984 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 370565001985 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 370565001986 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 370565001987 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 370565001988 Cation efflux family; Region: Cation_efflux; cl00316 370565001989 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 370565001990 RimM N-terminal domain; Region: RimM; pfam01782 370565001991 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 370565001992 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 370565001993 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 370565001994 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 370565001995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565001996 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 370565001997 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 370565001998 Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303 370565001999 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 370565002000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565002001 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 370565002002 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 370565002003 Helix-turn-helix domains; Region: HTH; cl00088 370565002004 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370565002005 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 370565002006 putative substrate binding site [chemical binding]; other site 370565002007 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 370565002008 putative ATP binding site [chemical binding]; other site 370565002009 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 370565002010 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 370565002011 active site 370565002012 phosphorylation site [posttranslational modification] 370565002013 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 370565002014 active site 370565002015 P-loop; other site 370565002016 phosphorylation site [posttranslational modification] 370565002017 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 370565002018 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 370565002019 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 370565002020 Integrase core domain; Region: rve_3; cl15866 370565002021 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 370565002022 Mac 1; Region: Mac-1; pfam09028 370565002023 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 370565002024 multimer interface [polypeptide binding]; other site 370565002025 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 370565002026 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 370565002027 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 370565002028 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 370565002029 active site 370565002030 NTP binding site [chemical binding]; other site 370565002031 metal binding triad [ion binding]; metal-binding site 370565002032 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 370565002033 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 370565002034 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 370565002035 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565002036 Walker A/P-loop; other site 370565002037 ATP binding site [chemical binding]; other site 370565002038 Q-loop/lid; other site 370565002039 ABC transporter signature motif; other site 370565002040 Walker B; other site 370565002041 D-loop; other site 370565002042 H-loop/switch region; other site 370565002043 ABC transporter; Region: ABC_tran_2; pfam12848 370565002044 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 370565002045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565002046 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 370565002047 active site 370565002048 catalytic residues [active] 370565002049 metal binding site [ion binding]; metal-binding site 370565002050 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 370565002051 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 370565002052 putative active site [active] 370565002053 putative metal binding site [ion binding]; other site 370565002054 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 370565002055 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 370565002056 synthetase active site [active] 370565002057 NTP binding site [chemical binding]; other site 370565002058 metal binding site [ion binding]; metal-binding site 370565002059 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 370565002060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370565002061 active site 370565002062 phosphorylation site [posttranslational modification] 370565002063 intermolecular recognition site; other site 370565002064 dimerization interface [polypeptide binding]; other site 370565002065 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 370565002066 DNA binding site [nucleotide binding] 370565002067 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 370565002068 dimer interface [polypeptide binding]; other site 370565002069 phosphorylation site [posttranslational modification] 370565002070 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370565002071 ATP binding site [chemical binding]; other site 370565002072 Mg2+ binding site [ion binding]; other site 370565002073 G-X-G motif; other site 370565002074 mevalonate kinase; Region: mevalon_kin; TIGR00549 370565002075 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 370565002076 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 370565002077 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 370565002078 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 370565002079 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 370565002080 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 370565002081 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 370565002082 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 370565002083 homotetramer interface [polypeptide binding]; other site 370565002084 FMN binding site [chemical binding]; other site 370565002085 homodimer contacts [polypeptide binding]; other site 370565002086 putative active site [active] 370565002087 putative substrate binding site [chemical binding]; other site 370565002088 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 370565002089 DDE superfamily endonuclease; Region: DDE_4; cl15789 370565002090 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 370565002091 homodimer interface [polypeptide binding]; other site 370565002092 catalytic residues [active] 370565002093 NAD binding site [chemical binding]; other site 370565002094 substrate binding pocket [chemical binding]; other site 370565002095 flexible flap; other site 370565002096 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 370565002097 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 370565002098 dimer interface [polypeptide binding]; other site 370565002099 active site 370565002100 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 370565002101 dimerization interface [polypeptide binding]; other site 370565002102 active site 370565002103 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 370565002104 folate binding site [chemical binding]; other site 370565002105 NADP+ binding site [chemical binding]; other site 370565002106 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 370565002107 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 370565002108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370565002109 Walker A motif; other site 370565002110 ATP binding site [chemical binding]; other site 370565002111 Walker B motif; other site 370565002112 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 370565002113 Predicted GTPase [General function prediction only]; Region: COG0218 370565002114 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 370565002115 G1 box; other site 370565002116 GTP/Mg2+ binding site [chemical binding]; other site 370565002117 Switch I region; other site 370565002118 G2 box; other site 370565002119 G3 box; other site 370565002120 Switch II region; other site 370565002121 G4 box; other site 370565002122 G5 box; other site 370565002123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370565002124 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 370565002125 Walker A motif; other site 370565002126 ATP binding site [chemical binding]; other site 370565002127 Walker B motif; other site 370565002128 arginine finger; other site 370565002129 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 370565002130 UvrB/uvrC motif; Region: UVR; pfam02151 370565002131 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370565002132 Walker A motif; other site 370565002133 ATP binding site [chemical binding]; other site 370565002134 Walker B motif; other site 370565002135 arginine finger; other site 370565002136 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 370565002137 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 370565002138 tetramer (dimer of dimers) interface [polypeptide binding]; other site 370565002139 active site 370565002140 dimer interface [polypeptide binding]; other site 370565002141 Sulfatase; Region: Sulfatase; cl10460 370565002142 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 370565002143 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 370565002144 ArsC family; Region: ArsC; pfam03960 370565002145 catalytic residues [active] 370565002146 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 370565002147 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 370565002148 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 370565002149 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 370565002150 Transcriptional regulator [Transcription]; Region: LysR; COG0583 370565002151 Helix-turn-helix domains; Region: HTH; cl00088 370565002152 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 370565002153 dimerization interface [polypeptide binding]; other site 370565002154 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 370565002155 active site 370565002156 dimer interface [polypeptide binding]; other site 370565002157 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 370565002158 active site 370565002159 amidase; Provisional; Region: PRK06529 370565002160 Amidase; Region: Amidase; cl11426 370565002161 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 370565002162 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 370565002163 substrate binding pocket [chemical binding]; other site 370565002164 membrane-bound complex binding site; other site 370565002165 hinge residues; other site 370565002166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370565002167 dimer interface [polypeptide binding]; other site 370565002168 conserved gate region; other site 370565002169 putative PBP binding loops; other site 370565002170 ABC-ATPase subunit interface; other site 370565002171 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 370565002172 ligand binding site [chemical binding]; other site 370565002173 active site 370565002174 UGI interface [polypeptide binding]; other site 370565002175 catalytic site [active] 370565002176 dihydroorotase; Validated; Region: pyrC; PRK09357 370565002177 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 370565002178 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 370565002179 active site 370565002180 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 370565002181 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 370565002182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 370565002183 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 370565002184 anchoring element; other site 370565002185 dimer interface [polypeptide binding]; other site 370565002186 ATP binding site [chemical binding]; other site 370565002187 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 370565002188 active site 370565002189 putative metal-binding site [ion binding]; other site 370565002190 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 370565002191 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 370565002192 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 370565002193 CAP-like domain; other site 370565002194 active site 370565002195 primary dimer interface [polypeptide binding]; other site 370565002196 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 370565002197 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 370565002198 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 370565002199 homodimer interface [polypeptide binding]; other site 370565002200 substrate-cofactor binding pocket; other site 370565002201 catalytic residue [active] 370565002202 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 370565002203 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 370565002204 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 370565002205 RNA binding site [nucleotide binding]; other site 370565002206 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 370565002207 RNA binding site [nucleotide binding]; other site 370565002208 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 370565002209 RNA binding site [nucleotide binding]; other site 370565002210 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 370565002211 RNA binding site [nucleotide binding]; other site 370565002212 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 370565002213 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 370565002214 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 370565002215 active site residue [active] 370565002216 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 370565002217 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 370565002218 dimer interface [polypeptide binding]; other site 370565002219 substrate binding pocket (H-site) [chemical binding]; other site 370565002220 N-terminal domain interface [polypeptide binding]; other site 370565002221 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 370565002222 gating phenylalanine in ion channel; other site 370565002223 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 370565002224 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565002225 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 370565002226 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 370565002227 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 370565002228 HflX GTPase family; Region: HflX; cd01878 370565002229 G1 box; other site 370565002230 GTP/Mg2+ binding site [chemical binding]; other site 370565002231 Switch I region; other site 370565002232 G2 box; other site 370565002233 G3 box; other site 370565002234 Switch II region; other site 370565002235 G4 box; other site 370565002236 G5 box; other site 370565002237 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 370565002238 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370565002239 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 370565002240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565002241 NAD(P) binding site [chemical binding]; other site 370565002242 active site 370565002243 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 370565002244 DHH family; Region: DHH; pfam01368 370565002245 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 370565002246 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 370565002247 active site 370565002248 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 370565002249 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 370565002250 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 370565002251 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 370565002252 minor groove reading motif; other site 370565002253 helix-hairpin-helix signature motif; other site 370565002254 substrate binding pocket [chemical binding]; other site 370565002255 active site 370565002256 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 370565002257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 370565002258 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 370565002259 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 370565002260 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 370565002261 FAD dependent oxidoreductase; Region: DAO; pfam01266 370565002262 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565002263 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 370565002264 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 370565002265 substrate binding site; other site 370565002266 tetramer interface; other site 370565002267 Cupin domain; Region: Cupin_2; cl09118 370565002268 Cupin domain; Region: Cupin_2; cl09118 370565002269 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 370565002270 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 370565002271 NAD binding site [chemical binding]; other site 370565002272 substrate binding site [chemical binding]; other site 370565002273 homodimer interface [polypeptide binding]; other site 370565002274 active site 370565002275 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 370565002276 putative active site [active] 370565002277 nucleotide binding site [chemical binding]; other site 370565002278 nudix motif; other site 370565002279 putative metal binding site [ion binding]; other site 370565002280 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 370565002281 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 370565002282 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 370565002283 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 370565002284 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 370565002285 Domain of unknown function (DUF814); Region: DUF814; pfam05670 370565002286 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 370565002287 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 370565002288 zinc binding site [ion binding]; other site 370565002289 putative ligand binding site [chemical binding]; other site 370565002290 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 370565002291 TM-ABC transporter signature motif; other site 370565002292 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 370565002293 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565002294 Walker A/P-loop; other site 370565002295 ATP binding site [chemical binding]; other site 370565002296 Q-loop/lid; other site 370565002297 ABC transporter signature motif; other site 370565002298 Walker B; other site 370565002299 D-loop; other site 370565002300 H-loop/switch region; other site 370565002301 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 370565002302 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370565002303 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 370565002304 Predicted esterase [General function prediction only]; Region: COG0627 370565002305 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 370565002306 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 370565002307 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 370565002308 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 370565002309 ABC transporter; Region: ABC_tran_2; pfam12848 370565002310 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 370565002311 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 370565002312 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 370565002313 tetramer interface [polypeptide binding]; other site 370565002314 TPP-binding site [chemical binding]; other site 370565002315 heterodimer interface [polypeptide binding]; other site 370565002316 phosphorylation loop region [posttranslational modification] 370565002317 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 370565002318 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 370565002319 alpha subunit interface [polypeptide binding]; other site 370565002320 TPP binding site [chemical binding]; other site 370565002321 heterodimer interface [polypeptide binding]; other site 370565002322 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 370565002323 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 370565002324 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 370565002325 E3 interaction surface; other site 370565002326 lipoyl attachment site [posttranslational modification]; other site 370565002327 e3 binding domain; Region: E3_binding; pfam02817 370565002328 e3 binding domain; Region: E3_binding; pfam02817 370565002329 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 370565002330 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 370565002331 E3 interaction surface; other site 370565002332 lipoyl attachment site [posttranslational modification]; other site 370565002333 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 370565002334 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 370565002335 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 370565002336 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 370565002337 substrate binding site [chemical binding]; other site 370565002338 catalytic residues [active] 370565002339 Polysaccharide lyase family 8, N terminal alpha-helical domain; Region: Lyase_8_N; pfam08124 370565002340 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 370565002341 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 370565002342 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 370565002343 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 370565002344 catalytic triad [active] 370565002345 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 370565002346 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 370565002347 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 370565002348 Uncharacterized conserved protein [Function unknown]; Region: COG1624 370565002349 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 370565002350 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 370565002351 YbbR-like protein; Region: YbbR; pfam07949 370565002352 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 370565002353 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 370565002354 active site 370565002355 substrate binding site [chemical binding]; other site 370565002356 metal binding site [ion binding]; metal-binding site 370565002357 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 370565002358 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370565002359 FeS/SAM binding site; other site 370565002360 HemN C-terminal domain; Region: HemN_C; pfam06969 370565002361 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 370565002362 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 370565002363 active site 370565002364 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 370565002365 active site 2 [active] 370565002366 active site 1 [active] 370565002367 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 370565002368 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 370565002369 active site 370565002370 motif I; other site 370565002371 motif II; other site 370565002372 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 370565002373 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 370565002374 Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms]; Region: COG3513 370565002375 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 370565002376 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 370565002377 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 370565002378 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 370565002379 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 370565002380 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd09758 370565002381 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 370565002382 multimer interface [polypeptide binding]; other site 370565002383 Nucleoside diphosphate kinases (NDP kinases, NDPks): NDP kinases, responsible for the synthesis of nucleoside triphosphates (NTPs), are involved in numerous regulatory processes associated with proliferation, development, and differentiation. They are...; Region: NDPk; cl00335 370565002384 active site 370565002385 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 370565002386 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 370565002387 Transposase [DNA replication, recombination, and repair]; Region: COG5433 370565002388 GTP-binding protein LepA; Provisional; Region: PRK05433 370565002389 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 370565002390 G1 box; other site 370565002391 putative GEF interaction site [polypeptide binding]; other site 370565002392 GTP/Mg2+ binding site [chemical binding]; other site 370565002393 Switch I region; other site 370565002394 G2 box; other site 370565002395 G3 box; other site 370565002396 Switch II region; other site 370565002397 G4 box; other site 370565002398 G5 box; other site 370565002399 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 370565002400 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 370565002401 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 370565002402 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 370565002403 Gram positive anchor; Region: Gram_pos_anchor; cl15427 370565002404 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 370565002405 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 370565002406 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 370565002407 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 370565002408 active pocket/dimerization site; other site 370565002409 active site 370565002410 phosphorylation site [posttranslational modification] 370565002411 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 370565002412 active site 370565002413 phosphorylation site [posttranslational modification] 370565002414 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 370565002415 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 370565002416 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 370565002417 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 370565002418 Histidine kinase; Region: His_kinase; pfam06580 370565002419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370565002420 ATP binding site [chemical binding]; other site 370565002421 Mg2+ binding site [ion binding]; other site 370565002422 G-X-G motif; other site 370565002423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370565002424 Response regulator receiver domain; Region: Response_reg; pfam00072 370565002425 active site 370565002426 phosphorylation site [posttranslational modification] 370565002427 intermolecular recognition site; other site 370565002428 dimerization interface [polypeptide binding]; other site 370565002429 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 370565002430 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 370565002431 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 370565002432 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 370565002433 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 370565002434 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 370565002435 NAD(P) binding site [chemical binding]; other site 370565002436 catalytic residues [active] 370565002437 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 370565002438 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 370565002439 GIY-YIG motif/motif A; other site 370565002440 active site 370565002441 catalytic site [active] 370565002442 putative DNA binding site [nucleotide binding]; other site 370565002443 metal binding site [ion binding]; metal-binding site 370565002444 UvrB/uvrC motif; Region: UVR; pfam02151 370565002445 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 370565002446 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 370565002447 dimer interface [polypeptide binding]; other site 370565002448 FMN binding site [chemical binding]; other site 370565002449 dipeptidase PepV; Reviewed; Region: PRK07318 370565002450 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 370565002451 active site 370565002452 metal binding site [ion binding]; metal-binding site 370565002453 trmE is a tRNA modification GTPase; Region: trmE; cd04164 370565002454 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 370565002455 G1 box; other site 370565002456 GTP/Mg2+ binding site [chemical binding]; other site 370565002457 Switch I region; other site 370565002458 G2 box; other site 370565002459 Switch II region; other site 370565002460 G3 box; other site 370565002461 G4 box; other site 370565002462 G5 box; other site 370565002463 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 370565002464 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 370565002465 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 370565002466 23S rRNA interface [nucleotide binding]; other site 370565002467 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 370565002468 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 370565002469 core dimer interface [polypeptide binding]; other site 370565002470 L10 interface [polypeptide binding]; other site 370565002471 L11 interface [polypeptide binding]; other site 370565002472 putative EF-Tu interaction site [polypeptide binding]; other site 370565002473 putative EF-G interaction site [polypeptide binding]; other site 370565002474 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 370565002475 cofactor binding site; other site 370565002476 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 370565002477 Lantibiotic streptin immunity protein; Region: Streptin-Immun; pfam11083 370565002478 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 370565002479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370565002480 active site 370565002481 phosphorylation site [posttranslational modification] 370565002482 intermolecular recognition site; other site 370565002483 dimerization interface [polypeptide binding]; other site 370565002484 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 370565002485 DNA binding site [nucleotide binding] 370565002486 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 370565002487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370565002488 ATP binding site [chemical binding]; other site 370565002489 Mg2+ binding site [ion binding]; other site 370565002490 G-X-G motif; other site 370565002491 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 370565002492 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 370565002493 Walker A/P-loop; other site 370565002494 ATP binding site [chemical binding]; other site 370565002495 Q-loop/lid; other site 370565002496 ABC transporter signature motif; other site 370565002497 Walker B; other site 370565002498 D-loop; other site 370565002499 H-loop/switch region; other site 370565002500 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 370565002501 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 370565002502 active site 370565002503 zinc binding site [ion binding]; other site 370565002504 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 370565002505 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 370565002506 SpaB C-terminal domain; Region: SpaB_C; cl14828 370565002507 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 370565002508 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 370565002509 Walker A/P-loop; other site 370565002510 ATP binding site [chemical binding]; other site 370565002511 Q-loop/lid; other site 370565002512 ABC transporter signature motif; other site 370565002513 Walker B; other site 370565002514 D-loop; other site 370565002515 H-loop/switch region; other site 370565002516 ABC-2 type transporter; Region: ABC2_membrane; cl11417 370565002517 ABC-2 type transporter; Region: ABC2_membrane; cl11417 370565002518 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370565002519 non-specific DNA binding site [nucleotide binding]; other site 370565002520 salt bridge; other site 370565002521 sequence-specific DNA binding site [nucleotide binding]; other site 370565002522 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370565002523 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370565002524 DNA binding site [nucleotide binding] 370565002525 Int/Topo IB signature motif; other site 370565002526 active site 370565002527 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 370565002528 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 370565002529 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 370565002530 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 370565002531 putative active site [active] 370565002532 putative metal binding site [ion binding]; other site 370565002533 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 370565002534 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 370565002535 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 370565002536 homodecamer interface [polypeptide binding]; other site 370565002537 GTP cyclohydrolase I; Provisional; Region: PLN03044 370565002538 active site 370565002539 putative catalytic site residues [active] 370565002540 zinc binding site [ion binding]; other site 370565002541 GTP-CH-I/GFRP interaction surface; other site 370565002542 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 370565002543 dihydropteroate synthase; Region: DHPS; TIGR01496 370565002544 substrate binding pocket [chemical binding]; other site 370565002545 dimer interface [polypeptide binding]; other site 370565002546 inhibitor binding site; inhibition site 370565002547 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 370565002548 homooctamer interface [polypeptide binding]; other site 370565002549 active site 370565002550 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 370565002551 catalytic center binding site [active] 370565002552 ATP binding site [chemical binding]; other site 370565002553 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 370565002554 FAD binding domain; Region: FAD_binding_4; pfam01565 370565002555 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 370565002556 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 370565002557 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 370565002558 Walker A/P-loop; other site 370565002559 ATP binding site [chemical binding]; other site 370565002560 Q-loop/lid; other site 370565002561 ABC transporter signature motif; other site 370565002562 Walker B; other site 370565002563 D-loop; other site 370565002564 H-loop/switch region; other site 370565002565 TOBE domain; Region: TOBE_2; cl01440 370565002566 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 370565002567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370565002568 dimer interface [polypeptide binding]; other site 370565002569 conserved gate region; other site 370565002570 putative PBP binding loops; other site 370565002571 ABC-ATPase subunit interface; other site 370565002572 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 370565002573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370565002574 dimer interface [polypeptide binding]; other site 370565002575 conserved gate region; other site 370565002576 putative PBP binding loops; other site 370565002577 ABC-ATPase subunit interface; other site 370565002578 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 370565002579 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 370565002580 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 370565002581 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370565002582 active site 370565002583 phosphorylation site [posttranslational modification] 370565002584 intermolecular recognition site; other site 370565002585 dimerization interface [polypeptide binding]; other site 370565002586 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 370565002587 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 370565002588 2-hydroxycarboxylate transporter family; Region: 2HCT; cl01386 370565002589 Malic enzyme, N-terminal domain; Region: malic; pfam00390 370565002590 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 370565002591 putative NAD(P) binding site [chemical binding]; other site 370565002592 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 370565002593 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 370565002594 catalytic Zn binding site [ion binding]; other site 370565002595 structural Zn binding site [ion binding]; other site 370565002596 NAD(P) binding site [chemical binding]; other site 370565002597 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 370565002598 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 370565002599 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 370565002600 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 370565002601 Cl- selectivity filter; other site 370565002602 Cl- binding residues [ion binding]; other site 370565002603 pore gating glutamate residue; other site 370565002604 dimer interface [polypeptide binding]; other site 370565002605 H+/Cl- coupling transport residue; other site 370565002606 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 370565002607 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 370565002608 active site 370565002609 catalytic triad [active] 370565002610 oxyanion hole [active] 370565002611 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 370565002612 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 370565002613 hypothetical protein; Reviewed; Region: PRK00024 370565002614 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 370565002615 MPN+ (JAMM) motif; other site 370565002616 Zinc-binding site [ion binding]; other site 370565002617 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 370565002618 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 370565002619 catalytic triad [active] 370565002620 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 370565002621 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 370565002622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565002623 Putative amino acid metabolism; Region: DUF1831; pfam08866 370565002624 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 370565002625 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 370565002626 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 370565002627 catalytic residue [active] 370565002628 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 370565002629 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 370565002630 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 370565002631 active site 370565002632 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 370565002633 putative active site [active] 370565002634 putative metal binding residues [ion binding]; other site 370565002635 signature motif; other site 370565002636 putative triphosphate binding site [ion binding]; other site 370565002637 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 370565002638 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 370565002639 synthetase active site [active] 370565002640 NTP binding site [chemical binding]; other site 370565002641 metal binding site [ion binding]; metal-binding site 370565002642 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 370565002643 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 370565002644 active site 370565002645 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 370565002646 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 370565002647 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 370565002648 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 370565002649 putative NAD(P) binding site [chemical binding]; other site 370565002650 homotetramer interface [polypeptide binding]; other site 370565002651 homodimer interface [polypeptide binding]; other site 370565002652 active site 370565002653 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 370565002654 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565002655 Walker A/P-loop; other site 370565002656 ATP binding site [chemical binding]; other site 370565002657 Q-loop/lid; other site 370565002658 ABC transporter signature motif; other site 370565002659 Walker B; other site 370565002660 D-loop; other site 370565002661 H-loop/switch region; other site 370565002662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370565002663 dimer interface [polypeptide binding]; other site 370565002664 conserved gate region; other site 370565002665 ABC-ATPase subunit interface; other site 370565002666 NMT1-like family; Region: NMT1_2; cl15260 370565002667 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 370565002668 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 370565002669 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 370565002670 active site 370565002671 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 370565002672 active site 370565002673 xanthine permease; Region: pbuX; TIGR03173 370565002674 ApbE family; Region: ApbE; cl00643 370565002675 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 370565002676 active site 1 [active] 370565002677 dimer interface [polypeptide binding]; other site 370565002678 hexamer interface [polypeptide binding]; other site 370565002679 active site 2 [active] 370565002680 thymidine kinase; Provisional; Region: PRK04296 370565002681 peptide chain release factor 1; Validated; Region: prfA; PRK00591 370565002682 RF-1 domain; Region: RF-1; cl02875 370565002683 RF-1 domain; Region: RF-1; cl02875 370565002684 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 370565002685 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370565002686 S-adenosylmethionine binding site [chemical binding]; other site 370565002687 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 370565002688 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 370565002689 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 370565002690 Coenzyme A binding pocket [chemical binding]; other site 370565002691 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 370565002692 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 370565002693 dimer interface [polypeptide binding]; other site 370565002694 active site 370565002695 glycine-pyridoxal phosphate binding site [chemical binding]; other site 370565002696 folate binding site [chemical binding]; other site 370565002697 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 370565002698 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 370565002699 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 370565002700 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 370565002701 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565002702 Walker A/P-loop; other site 370565002703 ATP binding site [chemical binding]; other site 370565002704 Q-loop/lid; other site 370565002705 ABC transporter signature motif; other site 370565002706 Walker B; other site 370565002707 D-loop; other site 370565002708 H-loop/switch region; other site 370565002709 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 370565002710 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 370565002711 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 370565002712 Walker A/P-loop; other site 370565002713 ATP binding site [chemical binding]; other site 370565002714 Q-loop/lid; other site 370565002715 ABC transporter signature motif; other site 370565002716 Walker B; other site 370565002717 D-loop; other site 370565002718 H-loop/switch region; other site 370565002719 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 370565002720 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 370565002721 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 370565002722 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 370565002723 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 370565002724 tetramer (dimer of dimers) interface [polypeptide binding]; other site 370565002725 NAD binding site [chemical binding]; other site 370565002726 dimer interface [polypeptide binding]; other site 370565002727 substrate binding site [chemical binding]; other site 370565002728 DNA gyrase subunit A; Validated; Region: PRK05560 370565002729 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 370565002730 CAP-like domain; other site 370565002731 active site 370565002732 primary dimer interface [polypeptide binding]; other site 370565002733 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 370565002734 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 370565002735 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 370565002736 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 370565002737 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 370565002738 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 370565002739 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 370565002740 active site 370565002741 catalytic site [active] 370565002742 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 370565002743 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 370565002744 putative metal binding site [ion binding]; other site 370565002745 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 370565002746 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 370565002747 Haemolysin-III related; Region: HlyIII; cl03831 370565002748 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 370565002749 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 370565002750 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 370565002751 GTP/Mg2+ binding site [chemical binding]; other site 370565002752 G4 box; other site 370565002753 G5 box; other site 370565002754 G1 box; other site 370565002755 Switch I region; other site 370565002756 G2 box; other site 370565002757 G3 box; other site 370565002758 Switch II region; other site 370565002759 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 370565002760 RNA/DNA hybrid binding site [nucleotide binding]; other site 370565002761 active site 370565002762 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 370565002763 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 370565002764 DNA topoisomerase I; Validated; Region: PRK05582 370565002765 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 370565002766 active site 370565002767 interdomain interaction site; other site 370565002768 putative metal-binding site [ion binding]; other site 370565002769 nucleotide binding site [chemical binding]; other site 370565002770 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 370565002771 domain I; other site 370565002772 DNA binding groove [nucleotide binding] 370565002773 phosphate binding site [ion binding]; other site 370565002774 domain II; other site 370565002775 domain III; other site 370565002776 nucleotide binding site [chemical binding]; other site 370565002777 catalytic site [active] 370565002778 domain IV; other site 370565002779 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 370565002780 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 370565002781 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 370565002782 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 370565002783 D-lactate dehydrogenase; Validated; Region: PRK08605 370565002784 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565002785 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 370565002786 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 370565002787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565002788 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 370565002789 catalytic residues [active] 370565002790 oxaloacetate decarboxylase; Provisional; Region: PRK12331 370565002791 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 370565002792 metal binding site [ion binding]; metal-binding site 370565002793 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 370565002794 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 370565002795 putative active site [active] 370565002796 (T/H)XGH motif; other site 370565002797 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 370565002798 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 370565002799 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370565002800 active site 370565002801 DNA binding site [nucleotide binding] 370565002802 Int/Topo IB signature motif; other site 370565002803 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 370565002804 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370565002805 non-specific DNA binding site [nucleotide binding]; other site 370565002806 salt bridge; other site 370565002807 sequence-specific DNA binding site [nucleotide binding]; other site 370565002808 signal recognition particle protein; Provisional; Region: PRK10867 370565002809 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 370565002810 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 370565002811 P loop; other site 370565002812 GTP binding site [chemical binding]; other site 370565002813 Signal peptide binding domain; Region: SRP_SPB; pfam02978 370565002814 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 370565002815 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 370565002816 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 370565002817 DNA-binding site [nucleotide binding]; DNA binding site 370565002818 UTRA domain; Region: UTRA; cl01230 370565002819 GMP synthase; Reviewed; Region: guaA; PRK00074 370565002820 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 370565002821 AMP/PPi binding site [chemical binding]; other site 370565002822 candidate oxyanion hole; other site 370565002823 catalytic triad [active] 370565002824 potential glutamine specificity residues [chemical binding]; other site 370565002825 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 370565002826 ATP Binding subdomain [chemical binding]; other site 370565002827 Dimerization subdomain; other site 370565002828 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 370565002829 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 370565002830 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565002831 Walker A/P-loop; other site 370565002832 ATP binding site [chemical binding]; other site 370565002833 Q-loop/lid; other site 370565002834 ABC transporter signature motif; other site 370565002835 Walker B; other site 370565002836 D-loop; other site 370565002837 H-loop/switch region; other site 370565002838 ABC transporter; Region: ABC_tran_2; pfam12848 370565002839 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 370565002840 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 370565002841 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 370565002842 dimer interface [polypeptide binding]; other site 370565002843 pyridoxal binding site [chemical binding]; other site 370565002844 ATP binding site [chemical binding]; other site 370565002845 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 370565002846 DNA-binding site [nucleotide binding]; DNA binding site 370565002847 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 370565002848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370565002849 homodimer interface [polypeptide binding]; other site 370565002850 catalytic residue [active] 370565002851 ATP cone domain; Region: ATP-cone; pfam03477 370565002852 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 370565002853 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 370565002854 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 370565002855 putative active site [active] 370565002856 catalytic site [active] 370565002857 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 370565002858 putative active site [active] 370565002859 catalytic site [active] 370565002860 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 370565002861 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 370565002862 Potassium binding sites [ion binding]; other site 370565002863 Cesium cation binding sites [ion binding]; other site 370565002864 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 370565002865 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 370565002866 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 370565002867 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296 370565002868 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 370565002869 putative ADP-ribose binding site [chemical binding]; other site 370565002870 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 370565002871 lipoyl attachment site [posttranslational modification]; other site 370565002872 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 370565002873 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 370565002874 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 370565002875 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 370565002876 putative active site [active] 370565002877 putative FMN binding site [chemical binding]; other site 370565002878 putative substrate binding site [chemical binding]; other site 370565002879 putative catalytic residue [active] 370565002880 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 370565002881 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 370565002882 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 370565002883 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 370565002884 Flavoprotein; Region: Flavoprotein; cl08021 370565002885 Predicted membrane protein [Function unknown]; Region: COG4684 370565002886 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 370565002887 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 370565002888 active site 370565002889 substrate binding site [chemical binding]; other site 370565002890 metal binding site [ion binding]; metal-binding site 370565002891 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 370565002892 TM-ABC transporter signature motif; other site 370565002893 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 370565002894 TM-ABC transporter signature motif; other site 370565002895 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 370565002896 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 370565002897 Walker A/P-loop; other site 370565002898 ATP binding site [chemical binding]; other site 370565002899 Q-loop/lid; other site 370565002900 ABC transporter signature motif; other site 370565002901 Walker B; other site 370565002902 D-loop; other site 370565002903 H-loop/switch region; other site 370565002904 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 370565002905 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 370565002906 ligand binding site [chemical binding]; other site 370565002907 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 370565002908 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 370565002909 active site 370565002910 catalytic motif [active] 370565002911 Zn binding site [ion binding]; other site 370565002912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 370565002913 Methyltransferase domain; Region: Methyltransf_31; pfam13847 370565002914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370565002915 S-adenosylmethionine binding site [chemical binding]; other site 370565002916 pantothenate kinase; Provisional; Region: PRK05439 370565002917 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 370565002918 ATP-binding site [chemical binding]; other site 370565002919 CoA-binding site [chemical binding]; other site 370565002920 Mg2+-binding site [ion binding]; other site 370565002921 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 370565002922 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 370565002923 dimer interface [polypeptide binding]; other site 370565002924 phosphorylation site [posttranslational modification] 370565002925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370565002926 ATP binding site [chemical binding]; other site 370565002927 Mg2+ binding site [ion binding]; other site 370565002928 G-X-G motif; other site 370565002929 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 370565002930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370565002931 active site 370565002932 phosphorylation site [posttranslational modification] 370565002933 intermolecular recognition site; other site 370565002934 dimerization interface [polypeptide binding]; other site 370565002935 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 370565002936 DNA binding site [nucleotide binding] 370565002937 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 370565002938 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 370565002939 Zn binding site [ion binding]; other site 370565002940 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 370565002941 PhoU domain; Region: PhoU; pfam01895 370565002942 PhoU domain; Region: PhoU; pfam01895 370565002943 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 370565002944 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 370565002945 Walker A/P-loop; other site 370565002946 ATP binding site [chemical binding]; other site 370565002947 Q-loop/lid; other site 370565002948 ABC transporter signature motif; other site 370565002949 Walker B; other site 370565002950 D-loop; other site 370565002951 H-loop/switch region; other site 370565002952 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 370565002953 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 370565002954 Walker A/P-loop; other site 370565002955 ATP binding site [chemical binding]; other site 370565002956 Q-loop/lid; other site 370565002957 ABC transporter signature motif; other site 370565002958 Walker B; other site 370565002959 D-loop; other site 370565002960 H-loop/switch region; other site 370565002961 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 370565002962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370565002963 dimer interface [polypeptide binding]; other site 370565002964 conserved gate region; other site 370565002965 putative PBP binding loops; other site 370565002966 ABC-ATPase subunit interface; other site 370565002967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370565002968 dimer interface [polypeptide binding]; other site 370565002969 conserved gate region; other site 370565002970 putative PBP binding loops; other site 370565002971 ABC-ATPase subunit interface; other site 370565002972 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 370565002973 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 370565002974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370565002975 S-adenosylmethionine binding site [chemical binding]; other site 370565002976 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283 370565002977 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 370565002978 active site 370565002979 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 370565002980 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 370565002981 ArsC family; Region: ArsC; pfam03960 370565002982 putative catalytic residues [active] 370565002983 thiol/disulfide switch; other site 370565002984 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 370565002985 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 370565002986 active site 370565002987 Riboflavin kinase; Region: Flavokinase; cl03312 370565002988 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 370565002989 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 370565002990 RNA binding site [nucleotide binding]; other site 370565002991 active site 370565002992 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 370565002993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 370565002994 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 370565002995 Predicted membrane protein [Function unknown]; Region: COG4129 370565002996 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 370565002997 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 370565002998 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 370565002999 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 370565003000 FtsX-like permease family; Region: FtsX; cl15850 370565003001 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 370565003002 FtsX-like permease family; Region: FtsX; cl15850 370565003003 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 370565003004 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 370565003005 Walker A/P-loop; other site 370565003006 ATP binding site [chemical binding]; other site 370565003007 Q-loop/lid; other site 370565003008 ABC transporter signature motif; other site 370565003009 Walker B; other site 370565003010 D-loop; other site 370565003011 H-loop/switch region; other site 370565003012 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 370565003013 Helix-turn-helix domains; Region: HTH; cl00088 370565003014 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 370565003015 DNA-binding site [nucleotide binding]; DNA binding site 370565003016 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 370565003017 Asp23 family; Region: Asp23; cl00574 370565003018 CsbD-like; Region: CsbD; cl15799 370565003019 Asp23 family; Region: Asp23; cl00574 370565003020 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 370565003021 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 370565003022 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 370565003023 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565003024 Family description; Region: UvrD_C_2; cl15862 370565003025 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 370565003026 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 370565003027 Cation efflux family; Region: Cation_efflux; cl00316 370565003028 Cation efflux family; Region: Cation_efflux; cl00316 370565003029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 370565003030 CAMP factor (Cfa); Region: CAMP_factor; pfam07373 370565003031 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 370565003032 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 370565003033 substrate binding pocket [chemical binding]; other site 370565003034 membrane-bound complex binding site; other site 370565003035 hinge residues; other site 370565003036 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 370565003037 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565003038 Walker A/P-loop; other site 370565003039 ATP binding site [chemical binding]; other site 370565003040 Q-loop/lid; other site 370565003041 ABC transporter signature motif; other site 370565003042 Walker B; other site 370565003043 D-loop; other site 370565003044 H-loop/switch region; other site 370565003045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370565003046 dimer interface [polypeptide binding]; other site 370565003047 conserved gate region; other site 370565003048 ABC-ATPase subunit interface; other site 370565003049 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 370565003050 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 370565003051 PhnA protein; Region: PhnA; pfam03831 370565003052 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 370565003053 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 370565003054 glutaminase active site [active] 370565003055 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 370565003056 dimer interface [polypeptide binding]; other site 370565003057 active site 370565003058 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 370565003059 dimer interface [polypeptide binding]; other site 370565003060 active site 370565003061 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 370565003062 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 370565003063 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 370565003064 pyruvate kinase; Provisional; Region: PRK05826 370565003065 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 370565003066 domain interfaces; other site 370565003067 active site 370565003068 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 370565003069 active site 370565003070 ADP/pyrophosphate binding site [chemical binding]; other site 370565003071 dimerization interface [polypeptide binding]; other site 370565003072 allosteric effector site; other site 370565003073 fructose-1,6-bisphosphate binding site; other site 370565003074 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 370565003075 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 370565003076 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 370565003077 generic binding surface II; other site 370565003078 generic binding surface I; other site 370565003079 Predicted transcriptional regulators [Transcription]; Region: COG1725 370565003080 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 370565003081 DNA-binding site [nucleotide binding]; DNA binding site 370565003082 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 370565003083 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 370565003084 Walker A/P-loop; other site 370565003085 ATP binding site [chemical binding]; other site 370565003086 Q-loop/lid; other site 370565003087 ABC transporter signature motif; other site 370565003088 Walker B; other site 370565003089 D-loop; other site 370565003090 H-loop/switch region; other site 370565003091 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 370565003092 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 370565003093 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 370565003094 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 370565003095 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 370565003096 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 370565003097 Transcriptional regulators [Transcription]; Region: PurR; COG1609 370565003098 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 370565003099 DNA binding site [nucleotide binding] 370565003100 domain linker motif; other site 370565003101 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 370565003102 putative dimerization interface [polypeptide binding]; other site 370565003103 putative ligand binding site [chemical binding]; other site 370565003104 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 370565003105 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 370565003106 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370565003107 dimer interface [polypeptide binding]; other site 370565003108 conserved gate region; other site 370565003109 ABC-ATPase subunit interface; other site 370565003110 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 370565003111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370565003112 dimer interface [polypeptide binding]; other site 370565003113 conserved gate region; other site 370565003114 putative PBP binding loops; other site 370565003115 ABC-ATPase subunit interface; other site 370565003116 Helix-turn-helix domains; Region: HTH; cl00088 370565003117 Integrase core domain; Region: rve; cl01316 370565003118 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 370565003119 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 370565003120 DltD N-terminal region; Region: DltD_N; pfam04915 370565003121 DltD central region; Region: DltD_M; pfam04918 370565003122 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 370565003123 Phosphopantetheine attachment site; Region: PP-binding; cl09936 370565003124 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 370565003125 AMP-binding enzyme; Region: AMP-binding; cl15778 370565003126 acyl-CoA synthetase; Validated; Region: PRK08308 370565003127 AMP-binding enzyme; Region: AMP-binding; cl15778 370565003128 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 370565003129 excinuclease ABC subunit B; Provisional; Region: PRK05298 370565003130 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 370565003131 ATP binding site [chemical binding]; other site 370565003132 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 370565003133 nucleotide binding region [chemical binding]; other site 370565003134 ATP-binding site [chemical binding]; other site 370565003135 Ultra-violet resistance protein B; Region: UvrB; pfam12344 370565003136 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 370565003137 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 370565003138 substrate binding pocket [chemical binding]; other site 370565003139 membrane-bound complex binding site; other site 370565003140 hinge residues; other site 370565003141 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 370565003142 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 370565003143 substrate binding pocket [chemical binding]; other site 370565003144 membrane-bound complex binding site; other site 370565003145 hinge residues; other site 370565003146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370565003147 dimer interface [polypeptide binding]; other site 370565003148 conserved gate region; other site 370565003149 putative PBP binding loops; other site 370565003150 ABC-ATPase subunit interface; other site 370565003151 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 370565003152 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 370565003153 Walker A/P-loop; other site 370565003154 ATP binding site [chemical binding]; other site 370565003155 Q-loop/lid; other site 370565003156 ABC transporter signature motif; other site 370565003157 Walker B; other site 370565003158 D-loop; other site 370565003159 H-loop/switch region; other site 370565003160 DDE superfamily endonuclease; Region: DDE_4; cl15789 370565003161 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 370565003162 DDE superfamily endonuclease; Region: DDE_4; cl15789 370565003163 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 370565003164 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 370565003165 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 370565003166 hydrophobic ligand binding site; other site 370565003167 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 370565003168 active site 370565003169 methionine cluster; other site 370565003170 phosphorylation site [posttranslational modification] 370565003171 metal binding site [ion binding]; metal-binding site 370565003172 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 370565003173 active site 370565003174 P-loop; other site 370565003175 phosphorylation site [posttranslational modification] 370565003176 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 370565003177 Helix-turn-helix domains; Region: HTH; cl00088 370565003178 Helix-turn-helix domains; Region: HTH; cl00088 370565003179 PRD domain; Region: PRD; cl15445 370565003180 PRD domain; Region: PRD; cl15445 370565003181 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 370565003182 active site 370565003183 P-loop; other site 370565003184 phosphorylation site [posttranslational modification] 370565003185 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 370565003186 active site 370565003187 phosphorylation site [posttranslational modification] 370565003188 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 370565003189 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 370565003190 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 370565003191 GTPase CgtA; Reviewed; Region: obgE; PRK12297 370565003192 GTP1/OBG; Region: GTP1_OBG; pfam01018 370565003193 Obg GTPase; Region: Obg; cd01898 370565003194 G1 box; other site 370565003195 GTP/Mg2+ binding site [chemical binding]; other site 370565003196 Switch I region; other site 370565003197 G2 box; other site 370565003198 G3 box; other site 370565003199 Switch II region; other site 370565003200 G4 box; other site 370565003201 G5 box; other site 370565003202 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 370565003203 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 370565003204 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 370565003205 Helix-turn-helix domains; Region: HTH; cl00088 370565003206 HTH-like domain; Region: HTH_21; pfam13276 370565003207 Integrase core domain; Region: rve; cl01316 370565003208 Integrase core domain; Region: rve; cl01316 370565003209 Integrase core domain; Region: rve_3; cl15866 370565003210 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 370565003211 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 370565003212 RNA binding surface [nucleotide binding]; other site 370565003213 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 370565003214 active site 370565003215 uracil binding [chemical binding]; other site 370565003216 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 370565003217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370565003218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370565003219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 370565003220 hypothetical protein; Provisional; Region: PRK13663 370565003221 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 370565003222 CoenzymeA binding site [chemical binding]; other site 370565003223 subunit interaction site [polypeptide binding]; other site 370565003224 PHB binding site; other site 370565003225 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 370565003226 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 370565003227 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 370565003228 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 370565003229 catalytic residues [active] 370565003230 catalytic nucleophile [active] 370565003231 Recombinase; Region: Recombinase; pfam07508 370565003232 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 370565003233 PemK-like protein; Region: PemK; cl00995 370565003234 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 370565003235 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 370565003236 DNA binding residues [nucleotide binding] 370565003237 Cysteine-rich KTR; Region: Cys_rich_KTR; pfam14205 370565003238 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 370565003239 dimer interface [polypeptide binding]; other site 370565003240 phosphorylation site [posttranslational modification] 370565003241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370565003242 ATP binding site [chemical binding]; other site 370565003243 Mg2+ binding site [ion binding]; other site 370565003244 G-X-G motif; other site 370565003245 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 370565003246 DNA binding site [nucleotide binding] 370565003247 Response regulator receiver domain; Region: Response_reg; pfam00072 370565003248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370565003249 active site 370565003250 phosphorylation site [posttranslational modification] 370565003251 intermolecular recognition site; other site 370565003252 dimerization interface [polypeptide binding]; other site 370565003253 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 370565003254 FtsX-like permease family; Region: FtsX; cl15850 370565003255 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 370565003256 FtsX-like permease family; Region: FtsX; cl15850 370565003257 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 370565003258 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 370565003259 Walker A/P-loop; other site 370565003260 ATP binding site [chemical binding]; other site 370565003261 Q-loop/lid; other site 370565003262 ABC transporter signature motif; other site 370565003263 Walker B; other site 370565003264 D-loop; other site 370565003265 H-loop/switch region; other site 370565003266 Helix-turn-helix domains; Region: HTH; cl00088 370565003267 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 370565003268 MatE; Region: MatE; cl10513 370565003269 MatE; Region: MatE; cl10513 370565003270 Cysteine-rich KTR; Region: Cys_rich_KTR; pfam14205 370565003271 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 370565003272 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 370565003273 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 370565003274 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 370565003275 Helix-turn-helix domains; Region: HTH; cl00088 370565003276 WHG domain; Region: WHG; pfam13305 370565003277 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 370565003278 active site 370565003279 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 370565003280 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 370565003281 trimer interface [polypeptide binding]; other site 370565003282 active site 370565003283 substrate binding site [chemical binding]; other site 370565003284 CoA binding site [chemical binding]; other site 370565003285 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370565003286 non-specific DNA binding site [nucleotide binding]; other site 370565003287 salt bridge; other site 370565003288 sequence-specific DNA binding site [nucleotide binding]; other site 370565003289 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 370565003290 dimer interface [polypeptide binding]; other site 370565003291 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 370565003292 N-acetyl-D-glucosamine binding site [chemical binding]; other site 370565003293 catalytic residue [active] 370565003294 NlpC/P60 family; Region: NLPC_P60; cl11438 370565003295 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 370565003296 active site 370565003297 catalytic site [active] 370565003298 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 370565003299 Domain of unknown function DUF87; Region: DUF87; pfam01935 370565003300 AAA-like domain; Region: AAA_10; pfam12846 370565003301 MT-A70; Region: MT-A70; cl01947 370565003302 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 370565003303 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565003304 Walker A motif; other site 370565003305 ATP binding site [chemical binding]; other site 370565003306 Walker B motif; other site 370565003307 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 370565003308 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 370565003309 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl01584 370565003310 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783 370565003311 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 370565003312 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 370565003313 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 370565003314 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 370565003315 Serine Recombinase (SR) family, TndX-like transposase subfamily, catalytic domain; composed of large serine recombinases similar to Clostridium TndX and TnpX transposases. Serine recombinases catalyze site-specific recombination of DNA molecules by a...; Region: SR_TndX_transposase; cd03770 370565003316 putative catalytic residues [active] 370565003317 catalytic nucleophile [active] 370565003318 Recombinase; Region: Recombinase; pfam07508 370565003319 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 370565003320 Protein of unknown function (DUF737); Region: DUF737; pfam05300 370565003321 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 370565003322 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; cl01839 370565003323 ParB-like partition proteins; Region: parB_part; TIGR00180 370565003324 ParB-like nuclease domain; Region: ParBc; cl02129 370565003325 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 370565003326 AAA domain; Region: AAA_25; pfam13481 370565003327 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565003328 Walker A motif; other site 370565003329 ATP binding site [chemical binding]; other site 370565003330 Walker B motif; other site 370565003331 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 370565003332 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 370565003333 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 370565003334 DNA binding residues [nucleotide binding] 370565003335 Cysteine-rich KTR; Region: Cys_rich_KTR; pfam14205 370565003336 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 370565003337 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 370565003338 G1 box; other site 370565003339 putative GEF interaction site [polypeptide binding]; other site 370565003340 GTP/Mg2+ binding site [chemical binding]; other site 370565003341 Switch I region; other site 370565003342 G2 box; other site 370565003343 G3 box; other site 370565003344 Switch II region; other site 370565003345 G4 box; other site 370565003346 G5 box; other site 370565003347 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 370565003348 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 370565003349 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 370565003350 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 370565003351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 370565003352 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565003353 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 370565003354 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565003355 ATP binding site [chemical binding]; other site 370565003356 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565003357 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565003358 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 370565003359 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 370565003360 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 370565003361 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 370565003362 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 370565003363 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 370565003364 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 370565003365 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 370565003366 ParB-like nuclease domain; Region: ParBc; cl02129 370565003367 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 370565003368 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 370565003369 P-loop; other site 370565003370 Magnesium ion binding site [ion binding]; other site 370565003371 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 370565003372 Magnesium ion binding site [ion binding]; other site 370565003373 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 370565003374 TRAM domain; Region: TRAM; cl01282 370565003375 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 370565003376 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 370565003377 shikimate kinase; Reviewed; Region: aroK; PRK00131 370565003378 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 370565003379 ADP binding site [chemical binding]; other site 370565003380 magnesium binding site [ion binding]; other site 370565003381 putative shikimate binding site; other site 370565003382 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 370565003383 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 370565003384 hinge; other site 370565003385 active site 370565003386 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 370565003387 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 370565003388 active site 370565003389 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 370565003390 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 370565003391 DNA-binding site [nucleotide binding]; DNA binding site 370565003392 DRTGG domain; Region: DRTGG; cl12147 370565003393 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 370565003394 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 370565003395 active site 2 [active] 370565003396 active site 1 [active] 370565003397 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 370565003398 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 370565003399 Gram positive anchor; Region: Gram_pos_anchor; cl15427 370565003400 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 370565003401 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 370565003402 hinge; other site 370565003403 active site 370565003404 S-adenosylmethionine synthetase; Validated; Region: PRK05250 370565003405 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 370565003406 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 370565003407 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 370565003408 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 370565003409 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 370565003410 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 370565003411 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 370565003412 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 370565003413 Helix-turn-helix domains; Region: HTH; cl00088 370565003414 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 370565003415 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 370565003416 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 370565003417 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 370565003418 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 370565003419 Transposase [DNA replication, recombination, and repair]; Region: COG5433 370565003420 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 370565003421 GAF domain; Region: GAF; cl15785 370565003422 Protease prsW family; Region: PrsW-protease; cl15823 370565003423 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 370565003424 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565003425 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565003426 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565003427 ATP binding site [chemical binding]; other site 370565003428 putative Mg++ binding site [ion binding]; other site 370565003429 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 370565003430 nucleotide binding region [chemical binding]; other site 370565003431 ATP-binding site [chemical binding]; other site 370565003432 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 370565003433 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 370565003434 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 370565003435 tetrameric interface [polypeptide binding]; other site 370565003436 activator binding site; other site 370565003437 NADP binding site [chemical binding]; other site 370565003438 substrate binding site [chemical binding]; other site 370565003439 catalytic residues [active] 370565003440 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 370565003441 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 370565003442 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 370565003443 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 370565003444 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 370565003445 dimerization domain swap beta strand [polypeptide binding]; other site 370565003446 regulatory protein interface [polypeptide binding]; other site 370565003447 active site 370565003448 regulatory phosphorylation site [posttranslational modification]; other site 370565003449 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 370565003450 catalytic residues [active] 370565003451 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 370565003452 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 370565003453 Class I ribonucleotide reductase; Region: RNR_I; cd01679 370565003454 active site 370565003455 dimer interface [polypeptide binding]; other site 370565003456 catalytic residues [active] 370565003457 effector binding site; other site 370565003458 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 370565003459 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 370565003460 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 370565003461 dimer interface [polypeptide binding]; other site 370565003462 putative radical transfer pathway; other site 370565003463 diiron center [ion binding]; other site 370565003464 tyrosyl radical; other site 370565003465 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 370565003466 putative ion selectivity filter; other site 370565003467 putative pore gating glutamate residue; other site 370565003468 Helix-turn-helix domains; Region: HTH; cl00088 370565003469 HTH-like domain; Region: HTH_21; pfam13276 370565003470 Integrase core domain; Region: rve; cl01316 370565003471 Integrase core domain; Region: rve_3; cl15866 370565003472 CAAX protease self-immunity; Region: Abi; cl00558 370565003473 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 370565003474 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370565003475 non-specific DNA binding site [nucleotide binding]; other site 370565003476 salt bridge; other site 370565003477 sequence-specific DNA binding site [nucleotide binding]; other site 370565003478 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 370565003479 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 370565003480 motif 1; other site 370565003481 active site 370565003482 motif 2; other site 370565003483 motif 3; other site 370565003484 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 370565003485 DHHA1 domain; Region: DHHA1; pfam02272 370565003486 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 370565003487 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 370565003488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 370565003489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370565003490 S-adenosylmethionine binding site [chemical binding]; other site 370565003491 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 370565003492 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370565003493 putative substrate translocation pore; other site 370565003494 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 370565003495 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 370565003496 active site 370565003497 Zn binding site [ion binding]; other site 370565003498 Competence protein CoiA-like family; Region: CoiA; cl11541 370565003499 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 370565003500 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 370565003501 RNA binding surface [nucleotide binding]; other site 370565003502 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 370565003503 active site 370565003504 uracil binding [chemical binding]; other site 370565003505 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 370565003506 active site 370565003507 trimer interface [polypeptide binding]; other site 370565003508 allosteric site; other site 370565003509 active site lid [active] 370565003510 hexamer (dimer of trimers) interface [polypeptide binding]; other site 370565003511 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 370565003512 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 370565003513 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 370565003514 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 370565003515 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 370565003516 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 370565003517 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 370565003518 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 370565003519 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 370565003520 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 370565003521 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370565003522 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 370565003523 Competence protein; Region: Competence; cl00471 370565003524 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370565003525 SLBB domain; Region: SLBB; pfam10531 370565003526 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 370565003527 putative acyl-acceptor binding pocket; other site 370565003528 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 370565003529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 370565003530 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 370565003531 GIY-YIG motif/motif A; other site 370565003532 putative active site [active] 370565003533 putative metal binding site [ion binding]; other site 370565003534 K+ potassium transporter; Region: K_trans; cl15781 370565003535 K+ potassium transporter; Region: K_trans; cl15781 370565003536 K+ potassium transporter; Region: K_trans; cl15781 370565003537 helicase 45; Provisional; Region: PTZ00424 370565003538 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 370565003539 ATP binding site [chemical binding]; other site 370565003540 Mg++ binding site [ion binding]; other site 370565003541 motif III; other site 370565003542 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 370565003543 nucleotide binding region [chemical binding]; other site 370565003544 ATP-binding site [chemical binding]; other site 370565003545 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 370565003546 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 370565003547 G1 box; other site 370565003548 putative GEF interaction site [polypeptide binding]; other site 370565003549 GTP/Mg2+ binding site [chemical binding]; other site 370565003550 Switch I region; other site 370565003551 G2 box; other site 370565003552 G3 box; other site 370565003553 Switch II region; other site 370565003554 G4 box; other site 370565003555 G5 box; other site 370565003556 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 370565003557 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 370565003558 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 370565003559 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 370565003560 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 370565003561 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 370565003562 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 370565003563 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 370565003564 ATP-grasp domain; Region: ATP-grasp_4; cl03087 370565003565 recombination protein RecR; Reviewed; Region: recR; PRK00076 370565003566 RecR protein; Region: RecR; pfam02132 370565003567 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 370565003568 putative active site [active] 370565003569 putative metal-binding site [ion binding]; other site 370565003570 tetramer interface [polypeptide binding]; other site 370565003571 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 370565003572 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 370565003573 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 370565003574 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 370565003575 Helix-turn-helix domains; Region: HTH; cl00088 370565003576 3H domain; Region: 3H; pfam02829 370565003577 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 370565003578 catalytic core [active] 370565003579 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 370565003580 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 370565003581 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 370565003582 active site 370565003583 FMN binding site [chemical binding]; other site 370565003584 substrate binding site [chemical binding]; other site 370565003585 catalytic residues [active] 370565003586 homodimer interface [polypeptide binding]; other site 370565003587 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 370565003588 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 370565003589 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 370565003590 IHF dimer interface [polypeptide binding]; other site 370565003591 IHF - DNA interface [nucleotide binding]; other site 370565003592 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 370565003593 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 370565003594 active site 370565003595 catalytic triad [active] 370565003596 oxyanion hole [active] 370565003597 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 370565003598 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 370565003599 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 370565003600 Walker A/P-loop; other site 370565003601 ATP binding site [chemical binding]; other site 370565003602 Q-loop/lid; other site 370565003603 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 370565003604 ABC transporter signature motif; other site 370565003605 Walker B; other site 370565003606 D-loop; other site 370565003607 H-loop/switch region; other site 370565003608 Arginine repressor [Transcription]; Region: ArgR; COG1438 370565003609 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 370565003610 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 370565003611 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 370565003612 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 370565003613 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 370565003614 substrate binding pocket [chemical binding]; other site 370565003615 chain length determination region; other site 370565003616 substrate-Mg2+ binding site; other site 370565003617 catalytic residues [active] 370565003618 aspartate-rich region 1; other site 370565003619 active site lid residues [active] 370565003620 aspartate-rich region 2; other site 370565003621 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 370565003622 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 370565003623 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 370565003624 generic binding surface II; other site 370565003625 generic binding surface I; other site 370565003626 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 370565003627 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 370565003628 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 370565003629 homodimer interface [polypeptide binding]; other site 370565003630 NADP binding site [chemical binding]; other site 370565003631 substrate binding site [chemical binding]; other site 370565003632 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 370565003633 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 370565003634 active site 370565003635 substrate binding site [chemical binding]; other site 370565003636 metal binding site [ion binding]; metal-binding site 370565003637 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 370565003638 DNA photolyase; Region: DNA_photolyase; pfam00875 370565003639 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 370565003640 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 370565003641 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 370565003642 Walker A/P-loop; other site 370565003643 ATP binding site [chemical binding]; other site 370565003644 Q-loop/lid; other site 370565003645 ABC transporter signature motif; other site 370565003646 Walker B; other site 370565003647 D-loop; other site 370565003648 H-loop/switch region; other site 370565003649 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 370565003650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370565003651 dimer interface [polypeptide binding]; other site 370565003652 conserved gate region; other site 370565003653 putative PBP binding loops; other site 370565003654 ABC-ATPase subunit interface; other site 370565003655 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 370565003656 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 370565003657 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370565003658 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 370565003659 Walker A motif; other site 370565003660 ATP binding site [chemical binding]; other site 370565003661 Walker B motif; other site 370565003662 arginine finger; other site 370565003663 Helicase subunit of the DNA excision repair complex [DNA replication, recombination, and repair]; Region: UvrB; COG0556 370565003664 UvrB/uvrC motif; Region: UVR; pfam02151 370565003665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370565003666 Walker A motif; other site 370565003667 ATP binding site [chemical binding]; other site 370565003668 Walker B motif; other site 370565003669 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 370565003670 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 370565003671 nudix motif; other site 370565003672 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 370565003673 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 370565003674 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 370565003675 active site 370565003676 HIGH motif; other site 370565003677 nucleotide binding site [chemical binding]; other site 370565003678 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 370565003679 active site 370565003680 KMSKS motif; other site 370565003681 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 370565003682 tRNA binding surface [nucleotide binding]; other site 370565003683 anticodon binding site; other site 370565003684 DivIVA protein; Region: DivIVA; pfam05103 370565003685 DivIVA domain; Region: DivI1A_domain; TIGR03544 370565003686 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 370565003687 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 370565003688 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 370565003689 YGGT family; Region: YGGT; cl00508 370565003690 Protein of unknown function (DUF552); Region: DUF552; cl00775 370565003691 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 370565003692 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 370565003693 catalytic residue [active] 370565003694 cell division protein FtsZ; Validated; Region: PRK09330 370565003695 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 370565003696 nucleotide binding site [chemical binding]; other site 370565003697 SulA interaction site; other site 370565003698 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 370565003699 Cell division protein FtsA; Region: FtsA; cl11496 370565003700 Cell division protein FtsA; Region: FtsA; cl11496 370565003701 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 370565003702 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 370565003703 Cell division protein FtsQ; Region: FtsQ; pfam03799 370565003704 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 370565003705 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 370565003706 active site 370565003707 homodimer interface [polypeptide binding]; other site 370565003708 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 370565003709 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 370565003710 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 370565003711 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 370565003712 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565003713 G3 box; other site 370565003714 Switch II region; other site 370565003715 GTP/Mg2+ binding site [chemical binding]; other site 370565003716 G4 box; other site 370565003717 G5 box; other site 370565003718 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 370565003719 elongation factor G; Reviewed; Region: PRK12740 370565003720 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 370565003721 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565003722 G1 box; other site 370565003723 GTP/Mg2+ binding site [chemical binding]; other site 370565003724 G2 box; other site 370565003725 Switch I region; other site 370565003726 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 370565003727 active site residue [active] 370565003728 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 370565003729 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 370565003730 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 370565003731 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 370565003732 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 370565003733 dimerization interface [polypeptide binding]; other site 370565003734 DPS ferroxidase diiron center [ion binding]; other site 370565003735 ion pore; other site 370565003736 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 370565003737 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370565003738 FeS/SAM binding site; other site 370565003739 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 370565003740 Transcriptional regulators [Transcription]; Region: PurR; COG1609 370565003741 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 370565003742 DNA binding site [nucleotide binding] 370565003743 domain linker motif; other site 370565003744 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 370565003745 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 370565003746 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 370565003747 protein binding site [polypeptide binding]; other site 370565003748 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 370565003749 pantetheine-phosphate adenylyltransferase, bacterial; Region: coaD_prev_kdtB; TIGR01510 370565003750 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 370565003751 active site 370565003752 (T/H)XGH motif; other site 370565003753 Predicted archaeal methyltransferase [General function prediction only]; Region: COG2521 370565003754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370565003755 S-adenosylmethionine binding site [chemical binding]; other site 370565003756 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 370565003757 dimer interface [polypeptide binding]; other site 370565003758 active site 370565003759 carbamate kinase; Reviewed; Region: PRK12686 370565003760 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 370565003761 putative substrate binding site [chemical binding]; other site 370565003762 nucleotide binding site [chemical binding]; other site 370565003763 nucleotide binding site [chemical binding]; other site 370565003764 homodimer interface [polypeptide binding]; other site 370565003765 hypothetical protein; Provisional; Region: PRK07205 370565003766 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 370565003767 active site 370565003768 metal binding site [ion binding]; metal-binding site 370565003769 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 370565003770 ornithine carbamoyltransferase; Validated; Region: PRK02102 370565003771 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 370565003772 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565003773 Amidinotransferase; Region: Amidinotransf; cl12043 370565003774 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 370565003775 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 370565003776 ligand binding site [chemical binding]; other site 370565003777 flexible hinge region; other site 370565003778 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 370565003779 putative switch regulator; other site 370565003780 non-specific DNA interactions [nucleotide binding]; other site 370565003781 DNA binding site [nucleotide binding] 370565003782 sequence specific DNA binding site [nucleotide binding]; other site 370565003783 putative cAMP binding site [chemical binding]; other site 370565003784 Arginine repressor [Transcription]; Region: ArgR; COG1438 370565003785 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 370565003786 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 370565003787 B3/4 domain; Region: B3_4; cl11458 370565003788 Protein of unknown function (DUF419); Region: DUF419; cl15265 370565003789 Cache domain; Region: Cache_1; pfam02743 370565003790 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 370565003791 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 370565003792 Histidine kinase; Region: His_kinase; pfam06580 370565003793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370565003794 ATP binding site [chemical binding]; other site 370565003795 Mg2+ binding site [ion binding]; other site 370565003796 G-X-G motif; other site 370565003797 Response regulator receiver domain; Region: Response_reg; pfam00072 370565003798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370565003799 active site 370565003800 phosphorylation site [posttranslational modification] 370565003801 intermolecular recognition site; other site 370565003802 dimerization interface [polypeptide binding]; other site 370565003803 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 370565003804 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 370565003805 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 370565003806 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 370565003807 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 370565003808 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 370565003809 catalytic residues [active] 370565003810 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 370565003811 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 370565003812 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 370565003813 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 370565003814 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 370565003815 CRISPR-associated protein Cas8c/Csd1, subtype I-C/DVULG; Region: cas_Csd1; TIGR01863 370565003816 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 370565003817 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651 370565003818 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 370565003819 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 370565003820 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 370565003821 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565003822 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 370565003823 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 370565003824 active site 370565003825 HIGH motif; other site 370565003826 nucleotide binding site [chemical binding]; other site 370565003827 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 370565003828 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 370565003829 active site 370565003830 KMSKS motif; other site 370565003831 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 370565003832 tRNA binding surface [nucleotide binding]; other site 370565003833 anticodon binding site; other site 370565003834 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 370565003835 AAA domain; Region: AAA_18; pfam13238 370565003836 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565003837 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 370565003838 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 370565003839 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 370565003840 NeuB family; Region: NeuB; cl00496 370565003841 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 370565003842 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 370565003843 active site 370565003844 dimer interface [polypeptide binding]; other site 370565003845 metal binding site [ion binding]; metal-binding site 370565003846 Cupin domain; Region: Cupin_2; cl09118 370565003847 Cupin domain; Region: Cupin_2; cl09118 370565003848 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 370565003849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370565003850 S-adenosylmethionine binding site [chemical binding]; other site 370565003851 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 370565003852 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 370565003853 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 370565003854 shikimate binding site; other site 370565003855 NAD(P) binding site [chemical binding]; other site 370565003856 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 370565003857 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 370565003858 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 370565003859 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 370565003860 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 370565003861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370565003862 active site 370565003863 phosphorylation site [posttranslational modification] 370565003864 intermolecular recognition site; other site 370565003865 dimerization interface [polypeptide binding]; other site 370565003866 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 370565003867 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 370565003868 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 370565003869 Histidine kinase; Region: His_kinase; pfam06580 370565003870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 370565003871 Protein of unknown function, DUF624; Region: DUF624; cl02369 370565003872 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 370565003873 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 370565003874 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 370565003875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370565003876 dimer interface [polypeptide binding]; other site 370565003877 conserved gate region; other site 370565003878 putative PBP binding loops; other site 370565003879 ABC-ATPase subunit interface; other site 370565003880 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 370565003881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370565003882 putative PBP binding loops; other site 370565003883 dimer interface [polypeptide binding]; other site 370565003884 ABC-ATPase subunit interface; other site 370565003885 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 370565003886 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 370565003887 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 370565003888 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 370565003889 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 370565003890 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 370565003891 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 370565003892 DNA-binding site [nucleotide binding]; DNA binding site 370565003893 Transcriptional regulators [Transcription]; Region: PurR; COG1609 370565003894 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 370565003895 ligand binding site [chemical binding]; other site 370565003896 dimerization interface [polypeptide binding]; other site 370565003897 Protein of unknown function (DUF1237); Region: DUF1237; cl15402 370565003898 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 370565003899 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 370565003900 active site 370565003901 metal binding site [ion binding]; metal-binding site 370565003902 homodimer interface [polypeptide binding]; other site 370565003903 catalytic site [active] 370565003904 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 370565003905 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 370565003906 GPI biosynthesis protein family Pig-F; Region: PIG-F; pfam06699 370565003907 TRAM domain; Region: TRAM; cl01282 370565003908 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 370565003909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 370565003910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 370565003911 RecX family; Region: RecX; cl00936 370565003912 Protein of unknown function (DUF402); Region: DUF402; cl00979 370565003913 Transposase; Region: DEDD_Tnp_IS110; pfam01548 370565003914 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 370565003915 30S subunit binding site; other site 370565003916 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 370565003917 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 370565003918 active site 370565003919 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 370565003920 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 370565003921 ATP binding site [chemical binding]; other site 370565003922 putative Mg++ binding site [ion binding]; other site 370565003923 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 370565003924 nucleotide binding region [chemical binding]; other site 370565003925 ATP-binding site [chemical binding]; other site 370565003926 Uncharacterized conserved protein [Function unknown]; Region: COG1739 370565003927 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 370565003928 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 370565003929 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 370565003930 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 370565003931 dimer interface [polypeptide binding]; other site 370565003932 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370565003933 catalytic residue [active] 370565003934 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 370565003935 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 370565003936 RNA binding site [nucleotide binding]; other site 370565003937 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 370565003938 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 370565003939 active site 370565003940 motif I; other site 370565003941 motif II; other site 370565003942 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 370565003943 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 370565003944 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 370565003945 active site 370565003946 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 370565003947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370565003948 active site 370565003949 phosphorylation site [posttranslational modification] 370565003950 intermolecular recognition site; other site 370565003951 dimerization interface [polypeptide binding]; other site 370565003952 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 370565003953 DNA binding residues [nucleotide binding] 370565003954 dimerization interface [polypeptide binding]; other site 370565003955 Histidine kinase; Region: HisKA_3; pfam07730 370565003956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370565003957 ATP binding site [chemical binding]; other site 370565003958 Mg2+ binding site [ion binding]; other site 370565003959 G-X-G motif; other site 370565003960 Predicted membrane protein [Function unknown]; Region: COG4758 370565003961 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 370565003962 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 370565003963 Catalytic domain of Protein Kinases; Region: PKc; cd00180 370565003964 active site 370565003965 ATP binding site [chemical binding]; other site 370565003966 substrate binding site [chemical binding]; other site 370565003967 activation loop (A-loop); other site 370565003968 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 370565003969 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 370565003970 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 370565003971 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 370565003972 active site 370565003973 16S rRNA methyltransferase B; Provisional; Region: PRK14902 370565003974 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 370565003975 putative RNA binding site [nucleotide binding]; other site 370565003976 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370565003977 S-adenosylmethionine binding site [chemical binding]; other site 370565003978 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 370565003979 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 370565003980 putative active site [active] 370565003981 substrate binding site [chemical binding]; other site 370565003982 putative cosubstrate binding site; other site 370565003983 catalytic site [active] 370565003984 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 370565003985 substrate binding site [chemical binding]; other site 370565003986 primosome assembly protein PriA; Validated; Region: PRK05580 370565003987 primosome assembly protein PriA; Validated; Region: PRK05580 370565003988 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 370565003989 ATP binding site [chemical binding]; other site 370565003990 putative Mg++ binding site [ion binding]; other site 370565003991 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 370565003992 nucleotide binding region [chemical binding]; other site 370565003993 ATP-binding site [chemical binding]; other site 370565003994 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 370565003995 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 370565003996 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 370565003997 catalytic site [active] 370565003998 G-X2-G-X-G-K; other site 370565003999 hypothetical protein; Provisional; Region: PRK00106 370565004000 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 370565004001 Transcriptional regulator [Transcription]; Region: LysR; COG0583 370565004002 Helix-turn-helix domains; Region: HTH; cl00088 370565004003 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 370565004004 dimerization interface [polypeptide binding]; other site 370565004005 putative acyltransferase; Provisional; Region: PRK05790 370565004006 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 370565004007 dimer interface [polypeptide binding]; other site 370565004008 active site 370565004009 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370565004010 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370565004011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565004012 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 370565004013 NAD(P) binding site [chemical binding]; other site 370565004014 active site 370565004015 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 370565004016 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 370565004017 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 370565004018 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 370565004019 THUMP domain; Region: THUMP; cl12076 370565004020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 370565004021 cell division protein GpsB; Provisional; Region: PRK14127 370565004022 DivIVA domain; Region: DivI1A_domain; TIGR03544 370565004023 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 370565004024 Recombination protein U; Region: RecU; cl01314 370565004025 Transglycosylase; Region: Transgly; cl07896 370565004026 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 370565004027 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 370565004028 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 370565004029 trimer interface [polypeptide binding]; other site 370565004030 active site 370565004031 G bulge; other site 370565004032 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 370565004033 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 370565004034 homodimer interface [polypeptide binding]; other site 370565004035 NAD binding pocket [chemical binding]; other site 370565004036 ATP binding pocket [chemical binding]; other site 370565004037 Mg binding site [ion binding]; other site 370565004038 active-site loop [active] 370565004039 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 370565004040 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 370565004041 active site 370565004042 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 370565004043 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 370565004044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565004045 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 370565004046 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 370565004047 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 370565004048 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 370565004049 Walker A/P-loop; other site 370565004050 ATP binding site [chemical binding]; other site 370565004051 Q-loop/lid; other site 370565004052 ABC transporter signature motif; other site 370565004053 Walker B; other site 370565004054 D-loop; other site 370565004055 H-loop/switch region; other site 370565004056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370565004057 dimer interface [polypeptide binding]; other site 370565004058 conserved gate region; other site 370565004059 putative PBP binding loops; other site 370565004060 ABC-ATPase subunit interface; other site 370565004061 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 370565004062 DEAD-like helicases superfamily; Region: DEXDc; smart00487 370565004063 ATP binding site [chemical binding]; other site 370565004064 Mg++ binding site [ion binding]; other site 370565004065 motif III; other site 370565004066 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 370565004067 nucleotide binding region [chemical binding]; other site 370565004068 ATP-binding site [chemical binding]; other site 370565004069 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 370565004070 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 370565004071 Mg++ binding site [ion binding]; other site 370565004072 putative catalytic motif [active] 370565004073 putative substrate binding site [chemical binding]; other site 370565004074 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 370565004075 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 370565004076 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 370565004077 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 370565004078 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 370565004079 Septum formation initiator; Region: DivIC; cl11433 370565004080 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 370565004081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 370565004082 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 370565004083 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 370565004084 putative catalytic cysteine [active] 370565004085 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 370565004086 nucleotide binding site [chemical binding]; other site 370565004087 homotetrameric interface [polypeptide binding]; other site 370565004088 putative phosphate binding site [ion binding]; other site 370565004089 putative allosteric binding site; other site 370565004090 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 370565004091 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 370565004092 Walker A/P-loop; other site 370565004093 ATP binding site [chemical binding]; other site 370565004094 Q-loop/lid; other site 370565004095 ABC transporter signature motif; other site 370565004096 Walker B; other site 370565004097 D-loop; other site 370565004098 H-loop/switch region; other site 370565004099 Enterocin A Immunity; Region: EntA_Immun; pfam08951 370565004100 transketolase; Reviewed; Region: PRK05899 370565004101 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 370565004102 TPP-binding site [chemical binding]; other site 370565004103 dimer interface [polypeptide binding]; other site 370565004104 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 370565004105 PYR/PP interface [polypeptide binding]; other site 370565004106 dimer interface [polypeptide binding]; other site 370565004107 TPP binding site [chemical binding]; other site 370565004108 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 370565004109 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 370565004110 active site 370565004111 intersubunit interactions; other site 370565004112 catalytic residue [active] 370565004113 Helix-turn-helix domains; Region: HTH; cl00088 370565004114 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 370565004115 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 370565004116 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 370565004117 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 370565004118 amphipathic channel; other site 370565004119 Asn-Pro-Ala signature motifs; other site 370565004120 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 370565004121 glycerol kinase; Provisional; Region: glpK; PRK00047 370565004122 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 370565004123 N- and C-terminal domain interface [polypeptide binding]; other site 370565004124 active site 370565004125 MgATP binding site [chemical binding]; other site 370565004126 catalytic site [active] 370565004127 metal binding site [ion binding]; metal-binding site 370565004128 glycerol binding site [chemical binding]; other site 370565004129 homotetramer interface [polypeptide binding]; other site 370565004130 homodimer interface [polypeptide binding]; other site 370565004131 FBP binding site [chemical binding]; other site 370565004132 protein IIAGlc interface [polypeptide binding]; other site 370565004133 Predicted membrane protein [Function unknown]; Region: COG3212 370565004134 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 370565004135 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 370565004136 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 370565004137 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 370565004138 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 370565004139 dimer interface [polypeptide binding]; other site 370565004140 motif 1; other site 370565004141 active site 370565004142 motif 2; other site 370565004143 motif 3; other site 370565004144 Phospholipid methyltransferase; Region: PEMT; cl00763 370565004145 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 370565004146 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 370565004147 active site 370565004148 catalytic tetrad [active] 370565004149 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 370565004150 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 370565004151 active site 370565004152 dimer interface [polypeptide binding]; other site 370565004153 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 370565004154 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 370565004155 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 370565004156 PhoU domain; Region: PhoU; pfam01895 370565004157 PhoU domain; Region: PhoU; pfam01895 370565004158 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 370565004159 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 370565004160 Helix-turn-helix domains; Region: HTH; cl00088 370565004161 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 370565004162 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 370565004163 active site 370565004164 motif I; other site 370565004165 motif II; other site 370565004166 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 370565004167 Predicted membrane protein [Function unknown]; Region: COG2860 370565004168 UPF0126 domain; Region: UPF0126; pfam03458 370565004169 UPF0126 domain; Region: UPF0126; pfam03458 370565004170 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 370565004171 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 370565004172 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 370565004173 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 370565004174 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 370565004175 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 370565004176 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 370565004177 active site 370565004178 P-loop; other site 370565004179 phosphorylation site [posttranslational modification] 370565004180 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 370565004181 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 370565004182 Helix-turn-helix domains; Region: HTH; cl00088 370565004183 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370565004184 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 370565004185 metal-binding site [ion binding] 370565004186 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 370565004187 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 370565004188 metal-binding site [ion binding] 370565004189 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 370565004190 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 370565004191 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 370565004192 Helix-turn-helix domains; Region: HTH; cl00088 370565004193 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 370565004194 Ribosome-binding factor A; Region: RBFA; cl00542 370565004195 translation initiation factor IF-2; Validated; Region: infB; PRK05306 370565004196 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 370565004197 translation initiation factor IF-2; Region: IF-2; TIGR00487 370565004198 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 370565004199 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 370565004200 G1 box; other site 370565004201 putative GEF interaction site [polypeptide binding]; other site 370565004202 GTP/Mg2+ binding site [chemical binding]; other site 370565004203 Switch I region; other site 370565004204 G2 box; other site 370565004205 G3 box; other site 370565004206 Switch II region; other site 370565004207 G4 box; other site 370565004208 G5 box; other site 370565004209 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 370565004210 Translation-initiation factor 2; Region: IF-2; pfam11987 370565004211 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 370565004212 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 370565004213 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 370565004214 putative RNA binding cleft [nucleotide binding]; other site 370565004215 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 370565004216 NusA N-terminal domain; Region: NusA_N; pfam08529 370565004217 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 370565004218 RNA binding site [nucleotide binding]; other site 370565004219 homodimer interface [polypeptide binding]; other site 370565004220 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 370565004221 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 370565004222 G-X-X-G motif; other site 370565004223 ribosome maturation protein RimP; Reviewed; Region: PRK00092 370565004224 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 370565004225 Sm1 motif; other site 370565004226 predicted subunit interaction site [polypeptide binding]; other site 370565004227 RNA binding pocket [nucleotide binding]; other site 370565004228 Sm2 motif; other site 370565004229 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 370565004230 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 370565004231 NlpC/P60 family; Region: NLPC_P60; cl11438 370565004232 Bacterial SH3 domain; Region: SH3_3; cl02551 370565004233 gp58-like protein; Region: Gp58; pfam07902 370565004234 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 370565004235 hypothetical protein; Region: PHA01795 370565004236 Phage tail protein; Region: Sipho_tail; pfam05709 370565004237 tape measure domain; Region: tape_meas_nterm; TIGR02675 370565004238 Phage protein; Region: DUF3647; cl10335 370565004239 Phage major tail protein 2; Region: Phage_tail_2; cl11463 370565004240 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 370565004241 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 370565004242 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 370565004243 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 370565004244 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 370565004245 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 370565004246 Phage terminase large subunit; Region: Terminase_3; cl12054 370565004247 Terminase-like family; Region: Terminase_6; pfam03237 370565004248 Terminase small subunit; Region: Terminase_2; cl01513 370565004249 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 370565004250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 370565004251 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 370565004252 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 370565004253 ATP binding site [chemical binding]; other site 370565004254 putative Mg++ binding site [ion binding]; other site 370565004255 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 370565004256 nucleotide binding region [chemical binding]; other site 370565004257 ATP-binding site [chemical binding]; other site 370565004258 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 370565004259 Phage associated DNA primase [General function prediction only]; Region: COG3378 370565004260 D5 N terminal like; Region: D5_N; cl07360 370565004261 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 370565004262 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642 370565004263 active site 370565004264 DNA binding site [nucleotide binding] 370565004265 catalytic site [active] 370565004266 Protein of unknown function (DUF2815); Region: DUF2815; pfam10991 370565004267 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 370565004268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 370565004269 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 370565004270 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 370565004271 Domain of unknown function (DUF955); Region: DUF955; cl01076 370565004272 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 370565004273 Int/Topo IB signature motif; other site 370565004274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370565004275 S-adenosylmethionine binding site [chemical binding]; other site 370565004276 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 370565004277 Phosphotransferase enzyme family; Region: APH; pfam01636 370565004278 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 370565004279 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 370565004280 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 370565004281 Walker A/P-loop; other site 370565004282 ATP binding site [chemical binding]; other site 370565004283 Q-loop/lid; other site 370565004284 ABC transporter signature motif; other site 370565004285 Walker B; other site 370565004286 D-loop; other site 370565004287 H-loop/switch region; other site 370565004288 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 370565004289 HIT family signature motif; other site 370565004290 catalytic residue [active] 370565004291 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 370565004292 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 370565004293 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 370565004294 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 370565004295 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 370565004296 active site 370565004297 motif I; other site 370565004298 motif II; other site 370565004299 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 370565004300 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 370565004301 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 370565004302 active pocket/dimerization site; other site 370565004303 active site 370565004304 phosphorylation site [posttranslational modification] 370565004305 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 370565004306 active site 370565004307 phosphorylation site [posttranslational modification] 370565004308 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 370565004309 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 370565004310 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 370565004311 Domain of unknown function (DUF956); Region: DUF956; cl01917 370565004312 seryl-tRNA synthetase; Provisional; Region: PRK05431 370565004313 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 370565004314 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 370565004315 dimer interface [polypeptide binding]; other site 370565004316 active site 370565004317 motif 1; other site 370565004318 motif 2; other site 370565004319 motif 3; other site 370565004320 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 370565004321 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 370565004322 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 370565004323 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 370565004324 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 370565004325 ATP-grasp domain; Region: ATP-grasp_4; cl03087 370565004326 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 370565004327 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 370565004328 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 370565004329 carboxyltransferase (CT) interaction site; other site 370565004330 biotinylation site [posttranslational modification]; other site 370565004331 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 370565004332 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 370565004333 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 370565004334 dimer interface [polypeptide binding]; other site 370565004335 active site 370565004336 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 370565004337 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 370565004338 NAD(P) binding site [chemical binding]; other site 370565004339 homotetramer interface [polypeptide binding]; other site 370565004340 homodimer interface [polypeptide binding]; other site 370565004341 active site 370565004342 Acyl transferase domain; Region: Acyl_transf_1; cl08282 370565004343 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 370565004344 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 370565004345 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 370565004346 FMN binding site [chemical binding]; other site 370565004347 substrate binding site [chemical binding]; other site 370565004348 putative catalytic residue [active] 370565004349 Phosphopantetheine attachment site; Region: PP-binding; cl09936 370565004350 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 370565004351 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 370565004352 dimer interface [polypeptide binding]; other site 370565004353 active site 370565004354 CoA binding pocket [chemical binding]; other site 370565004355 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 370565004356 Helix-turn-helix domains; Region: HTH; cl00088 370565004357 enoyl-CoA hydratase; Provisional; Region: PRK07260 370565004358 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 370565004359 substrate binding site [chemical binding]; other site 370565004360 oxyanion hole (OAH) forming residues; other site 370565004361 trimer interface [polypeptide binding]; other site 370565004362 chaperone protein DnaJ; Provisional; Region: PRK14276 370565004363 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 370565004364 HSP70 interaction site [polypeptide binding]; other site 370565004365 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 370565004366 substrate binding site [polypeptide binding]; other site 370565004367 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 370565004368 Zn binding sites [ion binding]; other site 370565004369 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 370565004370 substrate binding site [polypeptide binding]; other site 370565004371 dimer interface [polypeptide binding]; other site 370565004372 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 370565004373 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 370565004374 dimer interface [polypeptide binding]; other site 370565004375 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 370565004376 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 370565004377 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 370565004378 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 370565004379 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 370565004380 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 370565004381 catalytic core [active] 370565004382 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 370565004383 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 370565004384 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 370565004385 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 370565004386 GatB domain; Region: GatB_Yqey; cl11497 370565004387 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 370565004388 Amidase; Region: Amidase; cl11426 370565004389 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 370565004390 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 370565004391 Isochorismatase family; Region: Isochorismatase; pfam00857 370565004392 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 370565004393 catalytic triad [active] 370565004394 conserved cis-peptide bond; other site 370565004395 transcriptional repressor CodY; Validated; Region: PRK04158 370565004396 CodY GAF-like domain; Region: CodY; pfam06018 370565004397 Helix-turn-helix domains; Region: HTH; cl00088 370565004398 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 370565004399 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 370565004400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370565004401 homodimer interface [polypeptide binding]; other site 370565004402 catalytic residue [active] 370565004403 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 370565004404 Ligand Binding Site [chemical binding]; other site 370565004405 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 370565004406 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 370565004407 active site 370565004408 motif I; other site 370565004409 motif II; other site 370565004410 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 370565004411 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 370565004412 metal binding site [ion binding]; metal-binding site 370565004413 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 370565004414 active site 370565004415 homotetramer interface [polypeptide binding]; other site 370565004416 homodimer interface [polypeptide binding]; other site 370565004417 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 370565004418 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 370565004419 Walker A/P-loop; other site 370565004420 ATP binding site [chemical binding]; other site 370565004421 Q-loop/lid; other site 370565004422 ABC transporter signature motif; other site 370565004423 Walker B; other site 370565004424 D-loop; other site 370565004425 H-loop/switch region; other site 370565004426 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 370565004427 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 370565004428 generic binding surface II; other site 370565004429 ssDNA binding site; other site 370565004430 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 370565004431 ATP binding site [chemical binding]; other site 370565004432 putative Mg++ binding site [ion binding]; other site 370565004433 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 370565004434 nucleotide binding region [chemical binding]; other site 370565004435 ATP-binding site [chemical binding]; other site 370565004436 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 370565004437 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 370565004438 Walker A/P-loop; other site 370565004439 ATP binding site [chemical binding]; other site 370565004440 Q-loop/lid; other site 370565004441 ABC transporter signature motif; other site 370565004442 Walker B; other site 370565004443 D-loop; other site 370565004444 H-loop/switch region; other site 370565004445 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565004446 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 370565004447 Walker A/P-loop; other site 370565004448 ATP binding site [chemical binding]; other site 370565004449 Q-loop/lid; other site 370565004450 ABC transporter signature motif; other site 370565004451 Walker B; other site 370565004452 D-loop; other site 370565004453 H-loop/switch region; other site 370565004454 Cobalt transport protein; Region: CbiQ; cl00463 370565004455 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 370565004456 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 370565004457 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 370565004458 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 370565004459 Walker A/P-loop; other site 370565004460 ATP binding site [chemical binding]; other site 370565004461 Q-loop/lid; other site 370565004462 ABC transporter signature motif; other site 370565004463 Walker B; other site 370565004464 D-loop; other site 370565004465 H-loop/switch region; other site 370565004466 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 370565004467 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 370565004468 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565004469 Walker A/P-loop; other site 370565004470 ATP binding site [chemical binding]; other site 370565004471 Q-loop/lid; other site 370565004472 ABC transporter signature motif; other site 370565004473 Walker B; other site 370565004474 D-loop; other site 370565004475 H-loop/switch region; other site 370565004476 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 370565004477 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 370565004478 Walker A/P-loop; other site 370565004479 ATP binding site [chemical binding]; other site 370565004480 Q-loop/lid; other site 370565004481 ABC transporter signature motif; other site 370565004482 Walker B; other site 370565004483 D-loop; other site 370565004484 H-loop/switch region; other site 370565004485 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 370565004486 ABC-ATPase subunit interface; other site 370565004487 dimer interface [polypeptide binding]; other site 370565004488 putative PBP binding regions; other site 370565004489 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 370565004490 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 370565004491 putative ligand binding residues [chemical binding]; other site 370565004492 Cell surface heme-binding protein Shp; Region: HemeBinding_Shp; pfam11545 370565004493 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 370565004494 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 370565004495 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 370565004496 heme-binding site [chemical binding]; other site 370565004497 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 370565004498 Leucine-rich repeats; other site 370565004499 Leucine rich repeat; Region: LRR_8; pfam13855 370565004500 Substrate binding site [chemical binding]; other site 370565004501 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 370565004502 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 370565004503 heme-binding site [chemical binding]; other site 370565004504 Surface antigen [General function prediction only]; Region: COG3942 370565004505 NlpC/P60 family; Region: NLPC_P60; cl11438 370565004506 alanine racemase; Reviewed; Region: alr; PRK00053 370565004507 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 370565004508 active site 370565004509 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 370565004510 dimer interface [polypeptide binding]; other site 370565004511 substrate binding site [chemical binding]; other site 370565004512 catalytic residues [active] 370565004513 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 370565004514 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 370565004515 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 370565004516 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 370565004517 nucleotide binding region [chemical binding]; other site 370565004518 ATP-binding site [chemical binding]; other site 370565004519 SEC-C motif; Region: SEC-C; pfam02810 370565004520 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 370565004521 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 370565004522 Transposase [DNA replication, recombination, and repair]; Region: COG5433 370565004523 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 370565004524 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 370565004525 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 370565004526 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 370565004527 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 370565004528 active site 370565004529 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 370565004530 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 370565004531 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 370565004532 HPr interaction site; other site 370565004533 glycerol kinase (GK) interaction site [polypeptide binding]; other site 370565004534 active site 370565004535 phosphorylation site [posttranslational modification] 370565004536 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 370565004537 substrate binding [chemical binding]; other site 370565004538 active site 370565004539 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 370565004540 lac repressor; Reviewed; Region: lacI; PRK09526 370565004541 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 370565004542 DNA binding site [nucleotide binding] 370565004543 domain linker motif; other site 370565004544 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 370565004545 dimerization interface [polypeptide binding]; other site 370565004546 ligand binding site [chemical binding]; other site 370565004547 sodium binding site [ion binding]; other site 370565004548 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 370565004549 putative RNA binding site [nucleotide binding]; other site 370565004550 Asp23 family; Region: Asp23; cl00574 370565004551 elongation factor P; Validated; Region: PRK00529 370565004552 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 370565004553 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 370565004554 RNA binding site [nucleotide binding]; other site 370565004555 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 370565004556 RNA binding site [nucleotide binding]; other site 370565004557 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 370565004558 catalytic motif [active] 370565004559 Zn binding site [ion binding]; other site 370565004560 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 370565004561 aminopeptidase; Provisional; Region: PRK09795 370565004562 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 370565004563 active site 370565004564 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 370565004565 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 370565004566 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 370565004567 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 370565004568 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 370565004569 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 370565004570 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 370565004571 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 370565004572 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 370565004573 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 370565004574 dimer interface [polypeptide binding]; other site 370565004575 ssDNA binding site [nucleotide binding]; other site 370565004576 tetramer (dimer of dimers) interface [polypeptide binding]; other site 370565004577 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 370565004578 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 370565004579 helix-hairpin-helix signature motif; other site 370565004580 substrate binding pocket [chemical binding]; other site 370565004581 active site 370565004582 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 370565004583 DNA binding and oxoG recognition site [nucleotide binding] 370565004584 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370565004585 non-specific DNA binding site [nucleotide binding]; other site 370565004586 salt bridge; other site 370565004587 sequence-specific DNA binding site [nucleotide binding]; other site 370565004588 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 370565004589 catalytic residues [active] 370565004590 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 370565004591 active site 370565004592 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 370565004593 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 370565004594 Walker A/P-loop; other site 370565004595 ATP binding site [chemical binding]; other site 370565004596 Q-loop/lid; other site 370565004597 ABC transporter signature motif; other site 370565004598 Walker B; other site 370565004599 D-loop; other site 370565004600 H-loop/switch region; other site 370565004601 Smr domain; Region: Smr; cl02619 370565004602 Colicin V production protein; Region: Colicin_V; cl00567 370565004603 ribonuclease HIII; Provisional; Region: PRK00996 370565004604 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 370565004605 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 370565004606 RNA/DNA hybrid binding site [nucleotide binding]; other site 370565004607 active site 370565004608 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 370565004609 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 370565004610 Catalytic site [active] 370565004611 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 370565004612 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 370565004613 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 370565004614 DNA binding site [nucleotide binding] 370565004615 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565004616 Family description; Region: UvrD_C_2; cl15862 370565004617 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 370565004618 active site 370565004619 DNA polymerase IV; Validated; Region: PRK02406 370565004620 DNA binding site [nucleotide binding] 370565004621 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 370565004622 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 370565004623 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 370565004624 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 370565004625 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 370565004626 amphipathic channel; other site 370565004627 Asn-Pro-Ala signature motifs; other site 370565004628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370565004629 putative substrate translocation pore; other site 370565004630 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 370565004631 Helix-turn-helix domains; Region: HTH; cl00088 370565004632 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 370565004633 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 370565004634 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 370565004635 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370565004636 non-specific DNA binding site [nucleotide binding]; other site 370565004637 salt bridge; other site 370565004638 sequence-specific DNA binding site [nucleotide binding]; other site 370565004639 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370565004640 non-specific DNA binding site [nucleotide binding]; other site 370565004641 salt bridge; other site 370565004642 sequence-specific DNA binding site [nucleotide binding]; other site 370565004643 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 370565004644 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 370565004645 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 370565004646 DNA binding residues [nucleotide binding] 370565004647 dimer interface [polypeptide binding]; other site 370565004648 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 370565004649 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 370565004650 active site 370565004651 catalytic site [active] 370565004652 substrate binding site [chemical binding]; other site 370565004653 Helix-turn-helix domains; Region: HTH; cl00088 370565004654 HI0933-like protein; Region: HI0933_like; pfam03486 370565004655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565004656 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 370565004657 intersubunit interface [polypeptide binding]; other site 370565004658 active site 370565004659 catalytic residue [active] 370565004660 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 370565004661 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 370565004662 Nucleoside recognition; Region: Gate; cl00486 370565004663 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 370565004664 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 370565004665 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 370565004666 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 370565004667 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 370565004668 DNA-binding site [nucleotide binding]; DNA binding site 370565004669 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 370565004670 UGMP family protein; Validated; Region: PRK09604 370565004671 UGMP family protein; Validated; Region: PRK09604 370565004672 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 370565004673 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 370565004674 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 370565004675 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 370565004676 Coenzyme A binding pocket [chemical binding]; other site 370565004677 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 370565004678 Glycoprotease family; Region: Peptidase_M22; pfam00814 370565004679 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 370565004680 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 370565004681 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 370565004682 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 370565004683 glutamine synthetase, type I; Region: GlnA; TIGR00653 370565004684 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 370565004685 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 370565004686 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 370565004687 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 370565004688 DNA binding residues [nucleotide binding] 370565004689 putative dimer interface [polypeptide binding]; other site 370565004690 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 370565004691 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 370565004692 Phosphoglycerate kinase; Region: PGK; pfam00162 370565004693 substrate binding site [chemical binding]; other site 370565004694 hinge regions; other site 370565004695 ADP binding site [chemical binding]; other site 370565004696 catalytic site [active] 370565004697 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 370565004698 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 370565004699 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 370565004700 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 370565004701 DAK2 domain; Region: Dak2; cl03685 370565004702 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 370565004703 Asp23 family; Region: Asp23; cl00574 370565004704 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 370565004705 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 370565004706 hypothetical protein; Provisional; Region: PRK08185 370565004707 intersubunit interface [polypeptide binding]; other site 370565004708 active site 370565004709 zinc binding site [ion binding]; other site 370565004710 Na+ binding site [ion binding]; other site 370565004711 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 370565004712 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 370565004713 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 370565004714 CTP synthetase; Validated; Region: pyrG; PRK05380 370565004715 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 370565004716 Catalytic site [active] 370565004717 active site 370565004718 UTP binding site [chemical binding]; other site 370565004719 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 370565004720 active site 370565004721 putative oxyanion hole; other site 370565004722 catalytic triad [active] 370565004723 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 370565004724 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 370565004725 trigger factor; Provisional; Region: tig; PRK01490 370565004726 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 370565004727 Mechanosensitive ion channel; Region: MS_channel; pfam00924 370565004728 Protein of unknown function (DUF436); Region: DUF436; cl01860 370565004729 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 370565004730 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 370565004731 substrate binding site [chemical binding]; other site 370565004732 dimer interface [polypeptide binding]; other site 370565004733 ATP binding site [chemical binding]; other site 370565004734 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 370565004735 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 370565004736 dimerization interface 3.5A [polypeptide binding]; other site 370565004737 active site 370565004738 Glycerate kinase family; Region: Gly_kinase; cl00841 370565004739 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 370565004740 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 370565004741 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 370565004742 ATP binding site [chemical binding]; other site 370565004743 putative Mg++ binding site [ion binding]; other site 370565004744 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 370565004745 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 370565004746 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 370565004747 HsdM N-terminal domain; Region: HsdM_N; pfam12161 370565004748 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 370565004749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 370565004750 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 370565004751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370565004752 active site 370565004753 phosphorylation site [posttranslational modification] 370565004754 intermolecular recognition site; other site 370565004755 dimerization interface [polypeptide binding]; other site 370565004756 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 370565004757 DNA binding residues [nucleotide binding] 370565004758 dimerization interface [polypeptide binding]; other site 370565004759 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 370565004760 FtsX-like permease family; Region: FtsX; cl15850 370565004761 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 370565004762 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 370565004763 Walker A/P-loop; other site 370565004764 ATP binding site [chemical binding]; other site 370565004765 Q-loop/lid; other site 370565004766 ABC transporter signature motif; other site 370565004767 Walker B; other site 370565004768 D-loop; other site 370565004769 H-loop/switch region; other site 370565004770 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565004771 ABC transporter signature motif; other site 370565004772 Walker B; other site 370565004773 D-loop; other site 370565004774 H-loop/switch region; other site 370565004775 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 370565004776 Type-A lantibiotic; Region: L_biotic_typeA; pfam04604 370565004777 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 370565004778 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 370565004779 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 370565004780 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 370565004781 active site 370565004782 P-loop; other site 370565004783 phosphorylation site [posttranslational modification] 370565004784 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 370565004785 methionine cluster; other site 370565004786 active site 370565004787 phosphorylation site [posttranslational modification] 370565004788 metal binding site [ion binding]; metal-binding site 370565004789 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 370565004790 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 370565004791 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 370565004792 putative substrate binding site [chemical binding]; other site 370565004793 putative ATP binding site [chemical binding]; other site 370565004794 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 370565004795 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 370565004796 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 370565004797 Helix-turn-helix domains; Region: HTH; cl00088 370565004798 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370565004799 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 370565004800 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370565004801 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 370565004802 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 370565004803 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 370565004804 23S rRNA interface [nucleotide binding]; other site 370565004805 L3 interface [polypeptide binding]; other site 370565004806 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370565004807 non-specific DNA binding site [nucleotide binding]; other site 370565004808 salt bridge; other site 370565004809 sequence-specific DNA binding site [nucleotide binding]; other site 370565004810 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 370565004811 YacP-like NYN domain; Region: NYN_YacP; cl01491 370565004812 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 370565004813 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 370565004814 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 370565004815 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 370565004816 active site 370565004817 metal binding site [ion binding]; metal-binding site 370565004818 dimerization interface [polypeptide binding]; other site 370565004819 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 370565004820 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 370565004821 active site 370565004822 HIGH motif; other site 370565004823 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 370565004824 KMSKS motif; other site 370565004825 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 370565004826 tRNA binding surface [nucleotide binding]; other site 370565004827 anticodon binding site; other site 370565004828 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 370565004829 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 370565004830 trimer interface [polypeptide binding]; other site 370565004831 active site 370565004832 substrate binding site [chemical binding]; other site 370565004833 CoA binding site [chemical binding]; other site 370565004834 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 370565004835 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 370565004836 RNase E interface [polypeptide binding]; other site 370565004837 trimer interface [polypeptide binding]; other site 370565004838 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 370565004839 RNase E interface [polypeptide binding]; other site 370565004840 trimer interface [polypeptide binding]; other site 370565004841 active site 370565004842 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 370565004843 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 370565004844 RNA binding site [nucleotide binding]; other site 370565004845 domain interface; other site 370565004846 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 370565004847 active site 370565004848 intersubunit interactions; other site 370565004849 catalytic residue [active] 370565004850 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 370565004851 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 370565004852 active site 370565004853 P-loop; other site 370565004854 phosphorylation site [posttranslational modification] 370565004855 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 370565004856 PRD domain; Region: PRD; cl15445 370565004857 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 370565004858 active site 370565004859 P-loop; other site 370565004860 phosphorylation site [posttranslational modification] 370565004861 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 370565004862 active site 370565004863 phosphorylation site [posttranslational modification] 370565004864 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 370565004865 16S/18S rRNA binding site [nucleotide binding]; other site 370565004866 S13e-L30e interaction site [polypeptide binding]; other site 370565004867 25S rRNA binding site [nucleotide binding]; other site 370565004868 Helix-turn-helix domains; Region: HTH; cl00088 370565004869 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 370565004870 active site 370565004871 catalytic residues [active] 370565004872 metal binding site [ion binding]; metal-binding site 370565004873 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 370565004874 Helix-turn-helix domains; Region: HTH; cl00088 370565004875 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 370565004876 DNA polymerase III PolC; Validated; Region: polC; PRK00448 370565004877 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 370565004878 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 370565004879 generic binding surface II; other site 370565004880 generic binding surface I; other site 370565004881 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 370565004882 active site 370565004883 catalytic site [active] 370565004884 substrate binding site [chemical binding]; other site 370565004885 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 370565004886 prolyl-tRNA synthetase; Provisional; Region: PRK09194 370565004887 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 370565004888 dimer interface [polypeptide binding]; other site 370565004889 motif 1; other site 370565004890 active site 370565004891 motif 2; other site 370565004892 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 370565004893 putative deacylase active site [active] 370565004894 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 370565004895 active site 370565004896 motif 3; other site 370565004897 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 370565004898 anticodon binding site; other site 370565004899 RIP metalloprotease RseP; Region: TIGR00054 370565004900 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 370565004901 active site 370565004902 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 370565004903 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 370565004904 putative substrate binding region [chemical binding]; other site 370565004905 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 370565004906 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 370565004907 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 370565004908 catalytic residue [active] 370565004909 putative FPP diphosphate binding site; other site 370565004910 putative FPP binding hydrophobic cleft; other site 370565004911 dimer interface [polypeptide binding]; other site 370565004912 putative IPP diphosphate binding site; other site 370565004913 Preprotein translocase subunit; Region: YajC; cl00806 370565004914 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 370565004915 catalytic residues [active] 370565004916 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 370565004917 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 370565004918 carbohydrate binding site [chemical binding]; other site 370565004919 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 370565004920 carbohydrate binding site [chemical binding]; other site 370565004921 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 370565004922 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 370565004923 Ca binding site [ion binding]; other site 370565004924 active site 370565004925 catalytic site [active] 370565004926 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 370565004927 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 370565004928 Ca binding site [ion binding]; other site 370565004929 active site 370565004930 catalytic site [active] 370565004931 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 370565004932 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 370565004933 Walker A/P-loop; other site 370565004934 ATP binding site [chemical binding]; other site 370565004935 Q-loop/lid; other site 370565004936 ABC transporter signature motif; other site 370565004937 Walker B; other site 370565004938 D-loop; other site 370565004939 H-loop/switch region; other site 370565004940 TOBE domain; Region: TOBE_2; cl01440 370565004941 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 370565004942 Helix-turn-helix domains; Region: HTH; cl00088 370565004943 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 370565004944 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 370565004945 Staphylokinase/Streptokinase family; Region: Staphylokinase; pfam02821 370565004946 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cl00253 370565004947 putative active site [active] 370565004948 dimerization interface [polypeptide binding]; other site 370565004949 putative tRNAtyr binding site [nucleotide binding]; other site 370565004950 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 370565004951 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 370565004952 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 370565004953 synthetase active site [active] 370565004954 NTP binding site [chemical binding]; other site 370565004955 metal binding site [ion binding]; metal-binding site 370565004956 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 370565004957 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 370565004958 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 370565004959 flagellar motor switch protein; Validated; Region: PRK08119 370565004960 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 370565004961 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 370565004962 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 370565004963 putative catalytic site [active] 370565004964 putative metal binding site [ion binding]; other site 370565004965 putative phosphate binding site [ion binding]; other site 370565004966 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 370565004967 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 370565004968 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 370565004969 active site turn [active] 370565004970 phosphorylation site [posttranslational modification] 370565004971 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 370565004972 HPr interaction site; other site 370565004973 glycerol kinase (GK) interaction site [polypeptide binding]; other site 370565004974 active site 370565004975 phosphorylation site [posttranslational modification] 370565004976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 370565004977 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 370565004978 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 370565004979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 370565004980 S-adenosylmethionine binding site [chemical binding]; other site 370565004981 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 370565004982 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 370565004983 Integrase core domain; Region: rve_3; cl15866 370565004984 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 370565004985 DDE superfamily endonuclease; Region: DDE_4; cl15789 370565004986 aminodeoxychorismate synthase; Provisional; Region: PRK07508 370565004987 chorismate binding enzyme; Region: Chorismate_bind; cl10555 370565004988 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 370565004989 substrate-cofactor binding pocket; other site 370565004990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 370565004991 catalytic residue [active] 370565004992 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 370565004993 Glutamine amidotransferase class-I; Region: GATase; pfam00117 370565004994 glutamine binding [chemical binding]; other site 370565004995 catalytic triad [active] 370565004996 recombination factor protein RarA; Reviewed; Region: PRK13342 370565004997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370565004998 Walker A motif; other site 370565004999 ATP binding site [chemical binding]; other site 370565005000 Walker B motif; other site 370565005001 arginine finger; other site 370565005002 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 370565005003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 370565005004 Coenzyme A binding pocket [chemical binding]; other site 370565005005 topology modulation protein; Provisional; Region: PRK07261 370565005006 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565005007 Staphylococcal/Streptococcal toxin, OB-fold domain; Region: Stap_Strp_toxin; pfam01123 370565005008 Staphylococcal/Streptococcal toxin, beta-grasp domain; Region: Stap_Strp_tox_C; pfam02876 370565005009 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 370565005010 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 370565005011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370565005012 dimer interface [polypeptide binding]; other site 370565005013 conserved gate region; other site 370565005014 putative PBP binding loops; other site 370565005015 ABC-ATPase subunit interface; other site 370565005016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 370565005017 dimer interface [polypeptide binding]; other site 370565005018 conserved gate region; other site 370565005019 putative PBP binding loops; other site 370565005020 ABC-ATPase subunit interface; other site 370565005021 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 370565005022 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 370565005023 Walker A/P-loop; other site 370565005024 ATP binding site [chemical binding]; other site 370565005025 Q-loop/lid; other site 370565005026 ABC transporter signature motif; other site 370565005027 Walker B; other site 370565005028 D-loop; other site 370565005029 H-loop/switch region; other site 370565005030 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 370565005031 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 370565005032 Walker A/P-loop; other site 370565005033 ATP binding site [chemical binding]; other site 370565005034 Q-loop/lid; other site 370565005035 ABC transporter signature motif; other site 370565005036 Walker B; other site 370565005037 D-loop; other site 370565005038 H-loop/switch region; other site 370565005039 CsbD-like; Region: CsbD; cl15799 370565005040 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 370565005041 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 370565005042 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 370565005043 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 370565005044 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 370565005045 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 370565005046 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 370565005047 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 370565005048 metal binding site [ion binding]; metal-binding site 370565005049 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 370565005050 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 370565005051 Transposase [DNA replication, recombination, and repair]; Region: COG5433 370565005052 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 370565005053 putative active site [active] 370565005054 catalytic triad [active] 370565005055 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 370565005056 PA/protease domain interface [polypeptide binding]; other site 370565005057 putative integrin binding motif; other site 370565005058 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 370565005059 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 370565005060 FlgD Ig-like domain; Region: FlgD_ig; cl15790 370565005061 DDE superfamily endonuclease; Region: DDE_4; cl15789 370565005062 DDE superfamily endonuclease; Region: DDE_4; cl15789 370565005063 sic protein; Region: SIC; pfam03482 370565005064 Helix-turn-helix domains; Region: HTH; cl00088 370565005065 Helix-turn-helix domains; Region: HTH; cl00088 370565005066 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 370565005067 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 370565005068 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 370565005069 ribonuclease III; Provisional; Region: PRK14718 370565005070 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 370565005071 Surface antigen [General function prediction only]; Region: COG3942 370565005072 NlpC/P60 family; Region: NLPC_P60; cl11438 370565005073 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 370565005074 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 370565005075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 370565005076 dimer interface [polypeptide binding]; other site 370565005077 phosphorylation site [posttranslational modification] 370565005078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370565005079 ATP binding site [chemical binding]; other site 370565005080 Mg2+ binding site [ion binding]; other site 370565005081 G-X-G motif; other site 370565005082 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 370565005083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 370565005084 active site 370565005085 phosphorylation site [posttranslational modification] 370565005086 intermolecular recognition site; other site 370565005087 dimerization interface [polypeptide binding]; other site 370565005088 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 370565005089 DNA binding site [nucleotide binding] 370565005090 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 370565005091 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 370565005092 FtsX-like permease family; Region: FtsX; cl15850 370565005093 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 370565005094 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 370565005095 Walker A/P-loop; other site 370565005096 ATP binding site [chemical binding]; other site 370565005097 Q-loop/lid; other site 370565005098 ABC transporter signature motif; other site 370565005099 Walker B; other site 370565005100 D-loop; other site 370565005101 H-loop/switch region; other site 370565005102 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 370565005103 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 370565005104 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 370565005105 Staphylococcus aureus coagulase; Region: Coagulase; pfam08764 370565005106 cell division protein FtsN; Provisional; Region: PRK12757 370565005107 Fibronectin binding repeat; Region: Fn_bind; pfam02986 370565005108 Fibronectin binding repeat; Region: Fn_bind; pfam02986 370565005109 Fibronectin binding repeat; Region: Fn_bind; pfam02986 370565005110 Fibronectin binding repeat; Region: Fn_bind; pfam02986 370565005111 Gram positive anchor; Region: Gram_pos_anchor; cl15427 370565005112 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 370565005113 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 370565005114 metal ion-dependent adhesion site (MIDAS); other site 370565005115 foldase protein PrsA; Reviewed; Region: PRK12450 370565005116 Spi protease inhibitor; Region: Inhibitor_I69; pfam13734 370565005117 Spi protease inhibitor; Region: Inhibitor_I69; pfam13734 370565005118 Peptidase C10 family; Region: Peptidase_C10; pfam01640 370565005119 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 370565005120 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 370565005121 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 370565005122 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 370565005123 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 370565005124 tetramer interfaces [polypeptide binding]; other site 370565005125 binuclear metal-binding site [ion binding]; other site 370565005126 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 370565005127 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 370565005128 dimer interface [polypeptide binding]; other site 370565005129 active site 370565005130 metal binding site [ion binding]; metal-binding site 370565005131 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 370565005132 active site 370565005133 intersubunit interactions; other site 370565005134 catalytic residue [active] 370565005135 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 370565005136 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 370565005137 dimer interface [polypeptide binding]; other site 370565005138 active site 370565005139 glycine loop; other site 370565005140 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 370565005141 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 370565005142 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 370565005143 active site 370565005144 P-loop; other site 370565005145 phosphorylation site [posttranslational modification] 370565005146 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 370565005147 active site 370565005148 methionine cluster; other site 370565005149 phosphorylation site [posttranslational modification] 370565005150 metal binding site [ion binding]; metal-binding site 370565005151 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 370565005152 Helix-turn-helix domains; Region: HTH; cl00088 370565005153 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 370565005154 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 370565005155 Helix-turn-helix domains; Region: HTH; cl00088 370565005156 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 370565005157 active site 370565005158 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 370565005159 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 370565005160 FeS/SAM binding site; other site 370565005161 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 370565005162 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 370565005163 Transglycosylase; Region: Transgly; cl07896 370565005164 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 370565005165 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 370565005166 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 370565005167 homotrimer interaction site [polypeptide binding]; other site 370565005168 putative active site [active] 370565005169 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 370565005170 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 370565005171 active site 370565005172 Predicted membrane protein [Function unknown]; Region: COG4640 370565005173 Dipeptidase [Amino acid transport and metabolism]; Region: PepD; COG4690 370565005174 Peptidase family C69; Region: Peptidase_C69; pfam03577 370565005175 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 370565005176 non-specific DNA binding site [nucleotide binding]; other site 370565005177 salt bridge; other site 370565005178 sequence-specific DNA binding site [nucleotide binding]; other site 370565005179 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 370565005180 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 370565005181 ring oligomerisation interface [polypeptide binding]; other site 370565005182 ATP/Mg binding site [chemical binding]; other site 370565005183 stacking interactions; other site 370565005184 hinge regions; other site 370565005185 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 370565005186 oligomerisation interface [polypeptide binding]; other site 370565005187 mobile loop; other site 370565005188 roof hairpin; other site 370565005189 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 370565005190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370565005191 Walker A motif; other site 370565005192 ATP binding site [chemical binding]; other site 370565005193 Walker B motif; other site 370565005194 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 370565005195 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 370565005196 Clp amino terminal domain; Region: Clp_N; pfam02861 370565005197 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 370565005198 Walker A motif; other site 370565005199 ATP binding site [chemical binding]; other site 370565005200 Walker B motif; other site 370565005201 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 370565005202 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 370565005203 DNA-binding site [nucleotide binding]; DNA binding site 370565005204 RNA-binding motif; other site 370565005205 peroxiredoxin; Region: AhpC; TIGR03137 370565005206 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 370565005207 dimer interface [polypeptide binding]; other site 370565005208 decamer (pentamer of dimers) interface [polypeptide binding]; other site 370565005209 catalytic triad [active] 370565005210 peroxidatic and resolving cysteines [active] 370565005211 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 370565005212 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 370565005213 catalytic residue [active] 370565005214 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 370565005215 catalytic residues [active] 370565005216 glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378 370565005217 imidazolonepropionase; Validated; Region: PRK09356 370565005218 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 370565005219 active site 370565005220 urocanate hydratase; Provisional; Region: PRK05414 370565005221 Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643 370565005222 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 370565005223 Formiminotransferase domain; Region: FTCD; pfam02971 370565005224 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 370565005225 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 370565005226 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 370565005227 Potassium binding sites [ion binding]; other site 370565005228 Cesium cation binding sites [ion binding]; other site 370565005229 HutD; Region: HutD; cl01532 370565005230 amino acid transporter; Region: 2A0306; TIGR00909 370565005231 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 370565005232 active sites [active] 370565005233 tetramer interface [polypeptide binding]; other site 370565005234 Arginase family; Region: Arginase; cl00306 370565005235 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 370565005236 Predicted ATPase [General function prediction only]; Region: COG3899 370565005237 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565005238 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 370565005239 rRNA interaction site [nucleotide binding]; other site 370565005240 S8 interaction site; other site 370565005241 putative laminin-1 binding site; other site 370565005242 elongation factor Ts; Provisional; Region: tsf; PRK09377 370565005243 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 370565005244 Elongation factor TS; Region: EF_TS; pfam00889 370565005245 Elongation factor TS; Region: EF_TS; pfam00889 370565005246 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 370565005247 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 370565005248 active site 370565005249 Zn binding site [ion binding]; other site 370565005250 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 370565005251 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 370565005252 Ca binding site [ion binding]; other site 370565005253 active site 370565005254 catalytic site [active] 370565005255 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 370565005256 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 370565005257 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 370565005258 active site turn [active] 370565005259 phosphorylation site [posttranslational modification] 370565005260 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 370565005261 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 370565005262 HPr interaction site; other site 370565005263 glycerol kinase (GK) interaction site [polypeptide binding]; other site 370565005264 active site 370565005265 phosphorylation site [posttranslational modification] 370565005266 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 370565005267 DNA-binding site [nucleotide binding]; DNA binding site 370565005268 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 370565005269 UTRA domain; Region: UTRA; cl01230 370565005270 Helix-turn-helix domains; Region: HTH; cl00088 370565005271 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 370565005272 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 370565005273 putative metal binding site [ion binding]; other site 370565005274 Protein of unknown function (DUF328); Region: DUF328; cl01143 370565005275 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 370565005276 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 370565005277 Predicted acetyltransferase [General function prediction only]; Region: COG3981 370565005278 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 370565005279 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 370565005280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565005281 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 370565005282 ATP cone domain; Region: ATP-cone; pfam03477 370565005283 Class III ribonucleotide reductase; Region: RNR_III; cd01675 370565005284 effector binding site; other site 370565005285 active site 370565005286 Zn binding site [ion binding]; other site 370565005287 glycine loop; other site 370565005288 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 370565005289 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 370565005290 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 370565005291 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 370565005292 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 370565005293 ArsC family; Region: ArsC; pfam03960 370565005294 putative catalytic residues [active] 370565005295 thiol/disulfide switch; other site 370565005296 recombinase A; Provisional; Region: recA; PRK09354 370565005297 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 370565005298 hexamer interface [polypeptide binding]; other site 370565005299 Walker A motif; other site 370565005300 ATP binding site [chemical binding]; other site 370565005301 Walker B motif; other site 370565005302 competence damage-inducible protein A; Provisional; Region: PRK00549 370565005303 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 370565005304 putative MPT binding site; other site 370565005305 Competence-damaged protein; Region: CinA; cl00666 370565005306 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 370565005307 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 370565005308 RuvA N terminal domain; Region: RuvA_N; pfam01330 370565005309 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 370565005310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 370565005311 putative substrate translocation pore; other site 370565005312 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 370565005313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 370565005314 ATP binding site [chemical binding]; other site 370565005315 Mg2+ binding site [ion binding]; other site 370565005316 G-X-G motif; other site 370565005317 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 370565005318 ATP binding site [chemical binding]; other site 370565005319 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 370565005320 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 370565005321 MutS domain I; Region: MutS_I; pfam01624 370565005322 MutS domain II; Region: MutS_II; pfam05188 370565005323 MutS family domain IV; Region: MutS_IV; pfam05190 370565005324 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 370565005325 Walker A/P-loop; other site 370565005326 ATP binding site [chemical binding]; other site 370565005327 Q-loop/lid; other site 370565005328 ABC transporter signature motif; other site 370565005329 Walker B; other site 370565005330 D-loop; other site 370565005331 H-loop/switch region; other site 370565005332 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 370565005333 arginine repressor; Region: argR_whole; TIGR01529 370565005334 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 370565005335 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 370565005336 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 370565005337 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 370565005338 active site 370565005339 HIGH motif; other site 370565005340 KMSK motif region; other site 370565005341 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 370565005342 tRNA binding surface [nucleotide binding]; other site 370565005343 anticodon binding site; other site 370565005344 Enterocin A Immunity; Region: EntA_Immun; pfam08951 370565005345 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 370565005346 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 370565005347 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 370565005348 Uncharacterized conserved protein [Function unknown]; Region: COG1284 370565005349 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 370565005350 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 370565005351 Uncharacterized conserved protein [Function unknown]; Region: COG1284 370565005352 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 370565005353 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 370565005354 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 370565005355 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 370565005356 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 370565005357 dimer interface [polypeptide binding]; other site 370565005358 anticodon binding site; other site 370565005359 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 370565005360 homodimer interface [polypeptide binding]; other site 370565005361 motif 1; other site 370565005362 active site 370565005363 motif 2; other site 370565005364 GAD domain; Region: GAD; pfam02938 370565005365 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 370565005366 motif 3; other site 370565005367 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 370565005368 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 370565005369 dimer interface [polypeptide binding]; other site 370565005370 motif 1; other site 370565005371 active site 370565005372 motif 2; other site 370565005373 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 370565005374 anticodon binding site; other site 370565005375 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 370565005376 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 370565005377 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 370565005378 Cadmium resistance transporter; Region: Cad; pfam03596 370565005379 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 370565005380 putative DNA binding site [nucleotide binding]; other site 370565005381 putative Zn2+ binding site [ion binding]; other site 370565005382 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 370565005383 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565005384 AAA domain; Region: AAA_22; pfam13401 370565005385 Chloroplast import component protein (Tic20); Region: Tic20; cl09892 370565005386 Domain of unknown function (DUF368); Region: DUF368; cl00893 370565005387 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 370565005388 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 370565005389 Helix-turn-helix domains; Region: HTH; cl00088 370565005390 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 370565005391 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 370565005392 Predicted membrane protein [Function unknown]; Region: COG1511 370565005393 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 370565005394 ABC-2 type transporter; Region: ABC2_membrane; cl11417 370565005395 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 370565005396 Helix-turn-helix domains; Region: HTH; cl00088 370565005397 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 370565005398 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 370565005399 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 370565005400 RNA binding surface [nucleotide binding]; other site 370565005401 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 370565005402 replicative DNA helicase; Provisional; Region: PRK05748 370565005403 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 370565005404 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 370565005405 Walker A motif; other site 370565005406 ATP binding site [chemical binding]; other site 370565005407 Walker B motif; other site 370565005408 DNA binding loops [nucleotide binding] 370565005409 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 370565005410 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 370565005411 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 370565005412 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 370565005413 DHH family; Region: DHH; pfam01368 370565005414 DHHA1 domain; Region: DHHA1; pfam02272 370565005415 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 370565005416 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565005417 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 370565005418 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 370565005419 nudix motif; other site 370565005420 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 370565005421 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 370565005422 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 370565005423 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 370565005424 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 370565005425 putative L-serine binding site [chemical binding]; other site 370565005426 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 370565005427 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 370565005428 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 370565005429 Cobalt transport protein; Region: CbiQ; cl00463 370565005430 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 370565005431 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 370565005432 Walker A/P-loop; other site 370565005433 ATP binding site [chemical binding]; other site 370565005434 Q-loop/lid; other site 370565005435 ABC transporter signature motif; other site 370565005436 Walker B; other site 370565005437 D-loop; other site 370565005438 H-loop/switch region; other site 370565005439 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 370565005440 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 370565005441 Walker A/P-loop; other site 370565005442 ATP binding site [chemical binding]; other site 370565005443 Q-loop/lid; other site 370565005444 ABC transporter signature motif; other site 370565005445 Walker B; other site 370565005446 D-loop; other site 370565005447 H-loop/switch region; other site 370565005448 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 370565005449 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 370565005450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 370565005451 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 370565005452 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 370565005453 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 370565005454 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 370565005455 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 370565005456 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 370565005457 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 370565005458 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 370565005459 DXD motif; other site 370565005460 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 370565005461 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 370565005462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 370565005463 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 370565005464 active site 370565005465 tetramer interface; other site 370565005466 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 370565005467 recombination protein F; Reviewed; Region: recF; PRK00064 370565005468 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 370565005469 Walker A/P-loop; other site 370565005470 ATP binding site [chemical binding]; other site 370565005471 Q-loop/lid; other site 370565005472 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565005473 ABC transporter signature motif; other site 370565005474 Walker B; other site 370565005475 D-loop; other site 370565005476 H-loop/switch region; other site 370565005477 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 370565005478 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 370565005479 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 370565005480 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 370565005481 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 370565005482 active site 370565005483 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 370565005484 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 370565005485 active site 370565005486 HIGH motif; other site 370565005487 dimer interface [polypeptide binding]; other site 370565005488 KMSKS motif; other site 370565005489 Uncharacterized conserved protein [Function unknown]; Region: COG1284 370565005490 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 370565005491 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 370565005492 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 370565005493 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 370565005494 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 370565005495 Walker A/P-loop; other site 370565005496 ATP binding site [chemical binding]; other site 370565005497 Q-loop/lid; other site 370565005498 ABC transporter signature motif; other site 370565005499 Walker B; other site 370565005500 D-loop; other site 370565005501 H-loop/switch region; other site 370565005502 ABC transporter; Region: ABC_tran_2; pfam12848 370565005503 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 370565005504 Predicted membrane protein [Function unknown]; Region: COG4485 370565005505 Integrase core domain; Region: rve; cl01316 370565005506 Helix-turn-helix domains; Region: HTH; cl00088 370565005507 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 370565005508 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 370565005509 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 370565005510 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 370565005511 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 370565005512 protein binding site [polypeptide binding]; other site 370565005513 ParB-like partition proteins; Region: parB_part; TIGR00180 370565005514 ParB-like nuclease domain; Region: ParBc; cl02129 370565005515 Helix-turn-helix domains; Region: HTH; cl00088