-- dump date   	20111121_015111
-- class       	Genbank::CDS
-- table       	cds_note
-- id	note
YP_003025963.1	binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.
YP_003025964.1	binds the polymerase to DNA and acts as a sliding clamp
YP_003025968.1	translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1
YP_003025969.1	Enables the recycling of peptidyl-tRNAs produced at termination of translation
YP_003025979.1	in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall
YP_003025982.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP
YP_003025983.1	catalyzes the transamination of the aromatic amino acid forming a ketoacid; first step in aromatic amino acid degradation in lactococci
YP_003025984.1	involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA
YP_003025985.1	involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY
YP_003025987.1	catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase
YP_003025989.1	Catalyzes first step of the de novo purine nucleotide biosynthetic pathway
YP_003025990.1	catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis
YP_003025991.1	glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate
YP_003025992.1	involved in de novo purine biosynthesis
YP_003025993.1	catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis
YP_003025995.1	With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway
YP_003025997.1	N-terminal region is similar to Bacillus thuringiensis serovar konkukian str. 97-27 hypothetical protein. UniProt:Q5LK81 (EMBL:CP000047) (325 aa) fasta scores: E()=2.6e-22, 31.858% id in 339 aa
YP_003025998.1	Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide
YP_003026005.1	promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration
YP_003026011.1	CDS is possibly truncated in comparison to some proteins. Similar to the C-terminal region of Lactococcus lactis subsp. lactis (Streptococcus lactis) transposase UniProt:O34116 (EMBL:U91581) (439 aa) fasta scores: E()=6e-31, 37.456% id in 283 aa
YP_003026012.1	Weakly similar to SSU0136, 35.680% identity (37.789% ungapped) in 412 aa overlap (5-402:9-411)
YP_003026015.1	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
YP_003026016.1	plays an essential role in ATP-dependent branch migration of the Holliday junction
YP_003026019.1	CDS contains internal deletions relative to orthologues, residues 240 to 310
YP_003026020.1	catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs
YP_003026021.1	the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress
YP_003026023.1	similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function
YP_003026026.1	NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex
YP_003026027.1	binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin
YP_003026028.1	L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA
YP_003026029.1	binds third domain of 23S rRNA and protein L29; part of exit tunnel
YP_003026030.1	one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation
YP_003026031.1	protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YP_003026032.1	binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center
YP_003026033.1	forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation
YP_003026034.1	located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e
YP_003026035.1	one of the stabilizing components for the large ribosomal subunit
YP_003026036.1	primary binding protein; helps mediate assembly; involved in translation fidelity
YP_003026037.1	binds to the 23S rRNA between the centers for peptidyl transferase and GTPase
YP_003026038.1	assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel
YP_003026039.1	part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13
YP_003026042.1	binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YP_003026044.1	ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance
YP_003026045.1	binds 5S rRNA along with protein L5 and L25
YP_003026046.1	located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance
YP_003026047.1	L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7
YP_003026048.1	late assembly protein
YP_003026050.1	essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP
YP_003026051.1	stimulates the activities of the other two initiation factors, IF-2 and IF-3
YP_003026052.1	smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif
YP_003026053.1	located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA
YP_003026054.1	located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3
YP_003026055.1	catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme
YP_003026056.1	is a component of the macrolide binding site in the peptidyl transferase center
YP_003026075.1	catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr)
YP_003026076.1	CDS is truncated at the N-terminus in comparison to orthologues, for example Streptococcus pneumoniae Pbp1B penicillin-binding protein 1B UniProt:Q75YI4 (EMBL:AB119810) (820 aa) fasta scores: E()=2.5e-164, 57.755% id in 793 aa
YP_003026077.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme
YP_003026078.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter
YP_003026081.1	CDS differs in the length of the N-terminus in comparison to orthologues, for example, similar to Bacillus subtilis ComG operon protein 2 UniProt:P25954 (EMBL:BSJH6421) (323 aa) fasta scores: E()=5.6e-08, 25.000% id in 324 aa. Possible alternative translational start site after codons 5 and 22
YP_003026084.1	Possible alternative translational start site after codon 13
YP_003026085.1	Possible upstream alternative translational start site
YP_003026088.1	AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA
YP_003026090.1	Weakly similar to SSU0054, 35.680% identity (37.789% ungapped) in 412 aa overlap (9-411:5-402)
YP_003026097.1	binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA
YP_003026099.1	10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring
YP_003026100.1	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth
YP_003026101.1	interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance
YP_003026102.1	binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit
YP_003026103.1	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene
YP_003026106.1	Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway
YP_003026114.1	in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity
YP_003026117.1	Possible alternative upstream translational start site
YP_003026126.1	Similar to SSU1861, 74.464% identity (74.464% ungapped) in 466 aa overlap (1-466:1-466)
YP_003026130.1	membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr
YP_003026137.1	catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue
YP_003026140.1	involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function
YP_003026145.1	Similar to SSU0385, 62.500% identity (62.500% ungapped) in 32 aa overlap (1-32:1-32);SSU1880, 59.375% identity (59.375% ungapped) in 32 aa overlap (1-32:1-32);SSU1884, 54.839% identity (56.667% ungapped) in 31 aa overlap (2-32:1-30); and to an internal region of SSU0853, 53.125% identity (53.125% ungapped) in 32 aa overlap (1-32:43-74)
YP_003026157.1	An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids
YP_003026177.1	No significant database matches. Doubtful CDS
YP_003026178.1	converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer
YP_003026179.1	catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; subclass 1A is a dimer formed by two identical PyrD subunits each containing an FMN group
YP_003026188.1	CDS contains additional internal amino acids, residues 90 to 145, in comparison to orthologues
YP_003026198.1	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif
YP_003026199.1	some L32 proteins have zinc finger motifs consisting of CXXC while others do not
YP_003026200.1	catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG
YP_003026201.1	similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs
YP_003026203.1	catalyzes the formation of L-threonine from O-phospho-L-homoserine
YP_003026208.1	Possible alternative translational start sites after codons 1 and 11
YP_003026213.1	catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate
YP_003026216.1	ACT domain-containing protein
YP_003026219.1	Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
YP_003026220.1	with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor
YP_003026221.1	heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria
YP_003026222.1	chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion
YP_003026224.1	catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia
YP_003026227.1	Possible alternative translational start site after codon 2
YP_003026231.1	mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability
YP_003026232.1	catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine
YP_003026240.1	Similar to the C-terminal region of Homo sapiens (Human) RDH13 retinol dehydrogenase 13 UniProt:Q8NBN7 (EMBL:AY358473) (331 aa) fasta scores: E()=3.4e-16, 32.806% id in 253 aa
YP_003026246.1	Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer
YP_003026247.1	Similar to the C-terminal region of Staphylococcus epidermidis biofilm PIA synthesis N-acetylglucosaminyltransferase IcaA UniProt:Q8GLC5 (EMBL:AY138959) (412 aa) fasta scores: E()=3.7e-10, 30.328% id in 244 aa
YP_003026250.1	participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling
YP_003026251.1	CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer
YP_003026252.1	catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate
YP_003026253.1	required for 70S ribosome assembly
YP_003026257.1	broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor
YP_003026258.1	CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
YP_003026259.1	this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
YP_003026261.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain
YP_003026262.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_003026263.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_003026266.1	catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism
YP_003026267.1	catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism
YP_003026270.1	No significant database matches; Possible alternative translational start site after codon 7
YP_003026272.1	in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis
YP_003026274.1	transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria
YP_003026287.1	amylomaltase; acts to release glucose from maltodextrins
YP_003026302.1	glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA
YP_003026303.1	Possible alternative translational start site after codons 1 and 4
YP_003026304.1	functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC
YP_003026306.1	GpsB; guiding PBP1 shuttling; similar to DivIVA
YP_003026309.1	catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2
YP_003026311.1	Essential for recycling GMP and indirectly, cGMP
YP_003026312.1	Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
YP_003026313.1	binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity
YP_003026314.1	modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth
YP_003026329.1	binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities
YP_003026344.1	valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain
YP_003026347.1	C-terminal region is similar to Streptococcus pneumoniae helicase UniProt:Q97S40 (EMBL:AE007367) (548 aa) fasta scores: E()=1.3e-110, 55.657% id in 548 aa. Full length CDS is similar to Bacteroides fragilis probable helicase UniProt:Q64S40 (EMBL:AP006841) (970 aa) fasta scores: E()=4.9e-64, 36.773% id in 911 aa
YP_003026351.1	catalyzes the formation of asparagine from aspartate and ammonia
YP_003026354.1	Possible gene remnant. Weakly similar to the N-terminal region of Clostridium tetani DNA replication protein DnaC UniProt:Q899P7 (EMBL:AE015936) (329 aa) fasta scores: E()=7.2, 36.111% id in 72 aa
YP_003026355.1	Similar to SSU0450, 52.308% identity (52.308% ungapped) in 195 aa overlap (4-198:8-202)
YP_003026356.1	Similar to protein mediating epithelial cell invasion by virulent serotype III group B Streptococcus agalactiae, Spb1 UniProt:Q84A41 (EMBL:AF485279) (502 aa) fasta scores: E()=1.9e-05, 32.961% id in 537 aa
YP_003026358.1	UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation
YP_003026359.1	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis
YP_003026360.1	CDS is truncated at the C-terminus in comparison to some orthologues, for example, similar to Streptococcus pneumoniae cell division protein DivIB UniProt:Q9ZHA8 (EMBL:AF068902) (399 aa) fasta scores: E()=1.7e-28, 35.457% id in 361 aa
YP_003026362.1	GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function
YP_003026367.1	In comparison to orthologues, CDS lacks similarity in the C-terminal region, for example, similar to Streptococcus pneumoniae cell division protein DivIVA UniProt:Q9ZHB4 (EMBL:AF068901) (262 aa) fasta scores: E()=6.8e-42, 66.038% id in 212 aa
YP_003026369.1	IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme
YP_003026375.1	Similar to SSU0884, 65.984% identity (65.984% ungapped) in 244 aa overlap (1-244:1-244); SSU1676, 58.436% identity (58.678% ungapped) in 243 aa overlap (3-244:4-246); SSU1192, 55.556% identity (56.017% ungapped) in 243 aa overlap (4-244:2-244); and SSU1851, 54.545% identity (55.230% ungapped) in 242 aa overlap (5-243:1-242)
YP_003026376.1	catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate
YP_003026378.1	Similar to SSU0424, 52.308% identity (52.308% ungapped) in 195 aa overlap (8-202:4-198)
YP_003026380.1	Previously sequenced as Streptococcus suis sortase-like protein SrtE UniProt:Q8VUN6 (EMBL:AB066355) (275 aa) fasta scores: E()=8.4e-98, 100.000% id in 275 aa
YP_003026385.1	Doubtful CDS. No significant database matches
YP_003026390.1	catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense
YP_003026395.1	Doubtful CDS. No significant database matches
YP_003026396.1	class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1
YP_003026402.1	Possible gene remnant. Similar to the C-terminal regions of many protein, for example, Streptococcus mutans hypothetical protein SMU.709. UniProt:Q8DV12 (EMBL:AE014914) (174 aa) fasta scores: E()=5.2e-09, 38.281% id in 128 aa
YP_003026404.1	CDS is truncated at the C-terminus in comparison to orthologues
YP_003026405.1	catalyzes the formation of oxaloacetate from phosphoenolpyruvate
YP_003026408.1	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_003026409.1	Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate
YP_003026414.1	Identical to SSU1631, 100.000% identity (100.000% ungapped) in 387 aa overlap (1-387:1-387), SSU1247, 100.000% identity (100.000% ungapped) in 387 aa overlap (1-387:1-387), and SSU1036, 100.000% identity (100.000% ungapped) in 387 aa overlap (1-387:1-387)
YP_003026419.1	Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria.
YP_003026420.1	catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis
YP_003026421.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_003026426.1	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
YP_003026432.1	catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis
YP_003026433.1	Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway
YP_003026451.1	Possible gene remnant, CDS could be fragement of larger CDS including downstream CDSs
YP_003026452.1	Possible gene remnant, CDS could be fragement of larger CDS including upstream and downstream CDSs
YP_003026453.1	Possible gene remnant, CDS could be fragement of larger CDS including upstream CDSs
YP_003026459.1	N-terminal region is similar to SSU0530, 87.273% identity (87.273% ungapped) in 55 aa overlap (4-58:9-63)
YP_003026461.1	Full length CDS is similar to Synechocystis sp. (strain PCC 6803) transposase UniProt:Q55696 (EMBL:AP004311) (164 aa) fasta scores: E()=2.5e-16, 42.000% id in 150 aa. C-terminal region is similar to to Streptococcus pneumoniae IS630-Spn1, transposase Orf2 UniProt:Q97CV1 (EMBL:AE007319) (112 aa) fasta scores: E()=6.6e-33, 76.786% id in 112 aa, and to Synechocystis sp. (strain PCC 6803) transposase. UniProt:Q55696 (EMBL:AP004311) (164 aa) fasta scores: E()=2.5e-16, 42.000% id in 150 aa
YP_003026462.1	Possible gene remnant. Similar to the N-terminal region of several IS element proteins, for example, Streptococcus pneumoniae IS66 family element, Orf2 UniProt:Q97PZ5 (EMBL:AE007441) (116 aa) fasta scores: E()=1.9e-33, 84.211% id in 95 aa
YP_003026464.1	catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis
YP_003026465.1	catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis
YP_003026466.1	catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis
YP_003026474.1	Possible alternative translational start sites after codons 8, 11, 19 and 20.
YP_003026475.1	catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate
YP_003026476.1	catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_003026478.1	Similar to SSU1318, 51.765% identity (51.765% ungapped) in 85 aa overlap (3-87:2-86)
YP_003026485.1	catalyzes the degradation of arginine to citruline and ammonia
YP_003026487.1	catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway
YP_003026488.1	catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP
YP_003026491.1	Internal region is similar to Clostridium perfringens endo-beta-galactosidase C UniProt:Q8XNF8 (EMBL:BA000016) (845 aa) fasta scores: E()=1.6e-168, 55.637% id in 816 aa
YP_003026499.1	transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid
YP_003026501.1	D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid
YP_003026511.1	involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine
YP_003026520.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA.
YP_003026521.1	in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA
YP_003026523.1	catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine
YP_003026532.1	Possible alternative translational start sites after codons 9 and 10
YP_003026539.1	decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.
YP_003026540.1	Possible alternative translational start site after codon 2
YP_003026541.1	catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate
YP_003026543.1	Involved in disulfide oxidoreductase activity and electron transport
YP_003026546.1	Possible alternative upstream translational start sites. No significant database matches
YP_003026558.1	similar to transaldolase from Escherichia coli; many organisms have multiple copies
YP_003026560.1	forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone
YP_003026561.1	catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde
YP_003026562.1	catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis
YP_003026565.1	Converts glycerol and ADP to glycerol-3-phosphate and ADP
YP_003026567.1	Similar to SSU1752, 57.576% identity (57.576% ungapped) in 231 aa overlap (6-236:3-233)
YP_003026574.1	catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine
YP_003026575.1	catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP
YP_003026576.1	Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate
YP_003026585.1	Similar to bacteriophage PSA holin Hol UniProt:Q8W5Y9 (EMBL:BPS312240) (86 aa) fasta scores: E()=0.18, 33.333% id in 84 aa
YP_003026590.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
YP_003026592.1	essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication
YP_003026594.1	Previously sequenced as Streptococcus suis Mrp muramidase-released protein precursor (136 kDa surface protein) UniProt:P32653 (EMBL:SSMRP136) (1256 aa) fasta scores: E()=0, 100.000% id in 1256 aa
YP_003026597.1	involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX
YP_003026598.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_003026600.1	Possible alternative translational start sites. C-terminal region is similar to Pseudomonas putida (strain KT2440) hypothetical protein UniProt:Q88M59 (EMBL:AE016780) (145 aa) fasta scores: E()=8.1e-08, 36.885% id in 122 aa
YP_003026602.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_003026604.1	catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids
YP_003026606.1	in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins
YP_003026611.1	Required for the synthesis of the thiazole moiety
YP_003026614.1	involved in the peptidyltransferase reaction during translation
YP_003026615.1	Previously sequenced as Streptococcus suis CpsY UniProt:Q7X4K1 (EMBL:AF303229) (304 aa) fasta scores: E()=3.1e-110, 100.000% id in 304 aa. Similar to Streptococcus agalactiae capsule expression regulator CpsY UniProt:Q9Z5D1 (EMBL:SA17221) (307 aa) fasta scores: E()=1.4e-24, 31.392% id in 309 aa
YP_003026616.1	lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis
YP_003026620.1	regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity
YP_003026621.1	catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis
YP_003026622.1	catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers
YP_003026623.1	four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity
YP_003026625.1	catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline
YP_003026626.1	Possible alternative translational start sites
YP_003026632.1	catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine
YP_003026633.1	catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate
YP_003026634.1	catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis
YP_003026640.1	Highly similar to Streptococcus thermophilus cell envelope proteinase PrtS UniProt:Q9F8Q4 (EMBL:AF243528) (1585 aa) fasta scores: E()=0, 95.899% id in 1585 aa
YP_003026644.1	Essential for efficient processing of 16S rRNA
YP_003026645.1	methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA
YP_003026647.1	Possible alternative upstream translational start sites
YP_003026652.1	catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis
YP_003026653.1	catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity
YP_003026659.1	ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived
YP_003026662.1	binds and unfolds substrates as part of the ClpXP protease
YP_003026663.1	binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential
YP_003026664.1	catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate
YP_003026666.1	binds to the ribosome on the universally-conserved alpha-sarcin loop
YP_003026667.1	4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown
YP_003026668.1	C-terminal region is similar to the C-terminal regions of several proteins, for example: Bacillus anthracis conserved domain protein UniProt:Q81RA1 (EMBL:AE017030) (333 aa) fasta scores: E()=3.3e-09, 31.878% id in 229 aa, and to Bacillus cereus (strain ATCC 10987) hypothetical protein UniProt:Q739C7 (EMBL:AE017271) (332 aa) fasta scores: E()=7.4e-09, 38.776% id in 147 aa
YP_003026671.1	recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2
YP_003026675.1	catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate
YP_003026677.1	Similar to Streptococcus pneumoniae pneumococcal vaccine antigen A PvaA UniProt:Q9AHT6 (EMBL:AE007405) (204 aa) fasta scores: E()=3.2e-46, 64.141% id in 198 aa
YP_003026681.1	No significant database matches to the full length CDS. N-terminal region is similar to Streptococcus thermophilus (strain CNRZ 1066) hypothetical protein UniProt:Q5LY47 (EMBL:CP000024) (110 aa) fasta scores: E()=0.00049, 37.349% id in 83 aa, and the C-terminal region is similar to Streptococcus thermophilus (strain CNRZ 1066) hypothetical protein UniProt:Q5LY46 (EMBL:CP000024) (194 aa) fasta scores: E()=2.3e-21, 36.508% id in 189 aa
YP_003026683.1	C-terminal region is similar to the C-terminus of Escherichia coli 5-methylcytosine-specific restriction enzyme B McrB UniProt:P96754 (EMBL:ECAB1341) (465 aa) fasta scores: E()=1.7e-42, 49.835% id in 303 aa. Full length CDS is similar to Staphylococcus aureus (strain MRSA252) restriction enzyme UniProt:Q6GKL9 (EMBL:BX571856) (567 aa) fasta scores: E()=4e-107, 51.254% id in 558 aa
YP_003026684.1	McrC protein together with McrB forms the McrBC restriction system; recognizes N4- and C5-methylcytosine (and 5-hydroxy-methylcytosines); appears to act against 5-methylcytosine preceded by a purine residue; MrcC modulates the specificty of McrB and has DNA cleavage activity
YP_003026693.1	Weakly similar to Clostridium perfringens hypothetical protein cpe0886 UniProt:Q8XM04 (EMBL:BA000016) (261 aa) fasta scores: E()=1.5, 23.077% id in 247 aa
YP_003026697.1	contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway
YP_003026703.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS
YP_003026714.1	Possible gene remnant. Similar to the N-terminal region of Lactococcus lactis subsp. lactis (Streptococcus lactis) nisin immunity protein precursor NisI UniProt:P42708 (EMBL:LLNISABTC) (245 aa) fasta scores: E()=0.055, 31.387% id in 137 aa
YP_003026721.1	TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine
YP_003026723.1	present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors
YP_003026729.1	Possible alternative translational start site after codon 8
YP_003026731.1	Possible pseudogene. CDS contains additional internal amino acids, residues 31 to 64, in comparison to orthologues, for example, similar to Streptococcus agalactiae (serotype V) hypothetical protein sag1318 UniProt:Q8DZ04 (EMBL:AE014252) (149 aa) fasta scores: E()=5.7e-17, 46.286% id in 175 aa. Extra amino acids in the CDS are encoded by RepSU1 repeat
YP_003026734.1	RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids
YP_003026735.1	essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc)
YP_003026738.1	Previously sequenced as Streptococcus suis 5'-nucleotidase SntC UniProt:Q8VUM8 (EMBL:AB066357) (724 aa) fasta scores: E()=0, 98.619% id in 724 aa. C-terminal region is similar to Rattus norvegicus (Rat) 5'-nucleotidase precursor NT5E UniProt:P21588 (EMBL:RN5RPHP) (576 aa) fasta scores: E()=1.3e-15, 27.273% id in 583 aa
YP_003026739.1	catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis
YP_003026740.1	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
YP_003026743.1	CDS is truncated at the N-terminus in comparison to some orthologues
YP_003026744.1	type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase
YP_003026745.1	catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits
YP_003026746.1	responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the pyrD subunit to the ultimate electron acceptor NAD(+)
YP_003026755.1	CDS contains an atypical N-terminal LPNTG motif
YP_003026757.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion
YP_003026759.1	Similar to SSU0447, 65.984% identity (65.984% ungapped) in 244 aa overlap (1-244:1-244); SSU1676, 55.000% identity (55.230% ungapped) in 240 aa overlap (6-244:7-246); SSU1192, 53.719% identity (54.167% ungapped) in 242 aa overlap (6-245:4-245); SSU1851, 49.590% identity (50.207% ungapped) in 244 aa overlap (6-246:2-245)
YP_003026763.1	Possible alternative translational start site after codon 30
YP_003026766.1	catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside
YP_003026770.1	catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources
YP_003026771.1	catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate
YP_003026773.1	Doubtful CDS. No significant database matches
YP_003026784.1	in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta
YP_003026786.1	catalyzes the phosphorylation of NAD to NADP
YP_003026789.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP
YP_003026793.1	modulates transcription in response to the NADH/NAD(+) redox state
YP_003026795.1	Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase
YP_003026796.1	Previously sequenced as Streptococcus suis sortase SrtA UniProt:Q8VUP7 (EMBL:AB066353) (249 aa) fasta scores: E()=1.4e-91, 100.000% id in 249 aa
YP_003026797.1	negatively supercoils closed circular double-stranded DNA
YP_003026798.1	Converts (S)-lactate and NAD(+) to pyruvate and NADH
YP_003026803.1	Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis
YP_003026804.1	catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate
YP_003026805.1	Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway
YP_003026807.1	catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis
YP_003026808.1	binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase
YP_003026816.1	ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation
YP_003026817.1	ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation
YP_003026824.1	the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress
YP_003026826.1	catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities
YP_003026831.1	CDS contains a coiled-coiled domain, residues 357 to 385
YP_003026835.1	catalyzes the release of the N-terminal amino acid from a tripeptide
YP_003026851.1	involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer
YP_003026857.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily
YP_003026859.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily
YP_003026863.1	Converts D-mannonate to D-mannuronate
YP_003026864.1	catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate
YP_003026865.1	catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism
YP_003026873.1	adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active
YP_003026875.1	part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane
YP_003026876.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit
YP_003026877.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit
YP_003026878.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit
YP_003026879.1	Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex
YP_003026882.1	produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0
YP_003026883.1	similar to YegS from E. coli
YP_003026884.1	this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB
YP_003026887.1	catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate
YP_003026903.1	catalyzes the formation of citrate from acetyl-CoA and oxaloacetate
YP_003026904.1	Catalyzes the conversion of citrate to isocitrate
YP_003026906.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_003026908.1	B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE
YP_003026911.1	Doubtful CDS. No significant database matches
YP_003026918.1	Doubtful CDS. No significant database matches
YP_003026919.1	catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate
YP_003026922.1	Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate
YP_003026928.1	Possible alternative translational start sites after codons 13 and 19
YP_003026934.1	Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_003026942.1	methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content
YP_003026944.1	catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive
YP_003026945.1	catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive
YP_003026946.1	AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate
YP_003026947.1	catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis
YP_003026953.1	catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources
YP_003026956.1	catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate
YP_003026957.1	catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis
YP_003026958.1	catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis
YP_003026961.1	No significant database matches to the full length CDS. N-terminus is similar to the N-terminal region of Streptococcus pyogenes serotype M6 internalin protein UniProt:Q5XBJ5 (EMBL:CP000003) (792 aa) fasta scores: E()=2.8e-41, 42.105% id in 342 aa
YP_003026962.1	binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit
YP_003026964.1	IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits
YP_003026965.1	Catalyzes the formation of (d)CDP from ATP and (d)CMP
YP_003026985.1	CDS contains a sortase processing motif (LPXTS) after codon 314
YP_003026995.1	catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis
YP_003026996.1	catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis
YP_003027002.1	member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions
YP_003027005.1	IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity
YP_003027009.1	CDS is lack similarity and is extended at the C-terminus in comparison to orthologues. Similar to Streptococcus pneumoniae (strain ATCC BAA-255/R6) PhoH-like protein UniProt:Q8DQ46 (EMBL:AE008460) (322 aa) fasta scores: E()=2.4e-89, 88.462% id in 312 aa
YP_003027012.1	ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis
YP_003027014.1	Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs
YP_003027015.1	Catalyzes the phosphorylation of UMP to UDP
YP_003027018.1	Similar to Enterococcus faecalis (Streptococcus faecalis) bacteriocin immunity protein BacB UniProt:Q47779 (EMBL:EFD257) (94 aa) fasta scores: E()=1, 32.584% id in 89 aa
YP_003027019.1	in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA
YP_003027020.1	binds directly to 23S ribosomal RNA
YP_003027024.1	Similar to Escherichia coli sucrose-6-phosphate hydrolase CscA UniProt:P40714 (EMBL:ECCSCABKR) (477 aa) fasta scores: E()=2.3e-51, 35.730% id in 459 aa, and to Escherichia coli raffinose invertase RafD UniProt:P16553 (EMBL:ECRAF) (476 aa) fasta scores: E()=3.9e-49, 35.778% id in 450 aa
YP_003027034.1	stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein
YP_003027040.1	involved in a recombinational process of DNA repair, independent of the recBC complex
YP_003027042.1	Possible gene remnant linked to upstream CDS, SSU1188. Similar to an internal region of Staphylococcus aureus ATP-binding protein involved in resistance to virginiamycin A-like antibiotics Vga UniProt:Q53784 (EMBL:AF117259) (522 aa) fasta scores: E()=8.5e-19, 36.036% id in 222 aa
YP_003027043.1	Possible gene remnant linked to downstream CDS, SSU1187. Similar to an internal region of Staphylococcus aureus ATP-binding protein involved in resistance to virginiamycin A-like antibiotics Vga UniProt:Q53784 (EMBL:AF117259) (522 aa) fasta scores: E()=1.9e-12, 35.000% id in 180 aa
YP_003027047.1	Similar to SSU0447, 55.556% identity (56.017% ungapped) in 243 aa overlap (2-244:4-244); SSU0884, 53.719% identity (54.167% ungapped) in 242 aa overlap (4-245:6-245); SSU1851, 48.148% identity (48.750% ungapped) in 243 aa overlap (3-243:1-242); SSU1676, 46.091% identity (46.667% ungapped) in 243 aa overlap (3-244:6-246)
YP_003027051.1	catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr)
YP_003027052.1	Possible alternative translational start site. Similar to the C-terminal region of Streptococcus pneumoniae hypothetical protein SP1630 UniProt:Q97PI5 (EMBL:AE007456) (129 aa) fasta scores: E()=3e-24, 65.000% id in 100 aa. C-terminus is similar to Streptococcus pneumoniae (strain ATCC BAA-255/R6) hypothetical protein SPR1471 UniProt:Q8CYH7 (EMBL:AE008516) (59 aa) fasta scores: E()=1.1e-11, 67.241% id in 58 aa
YP_003027059.1	Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr)
YP_003027063.1	has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair
YP_003027068.1	antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein
YP_003027070.1	CDS is extended at the C-terminus in comparison to orthologues and contains a sortase processed surface-anchor motif. Similar to Streptococcus gordonii amylase-binding protein B AbpB UniProt:Q93TK2 (EMBL:AF354648) (652 aa) fasta scores: E()=1.7e-106, 57.216% id in 582 aa. C-terminal region is similar to Streptococcus pyogenes serotype M1 probable dipeptidase B PepDB UniProt:Q99XS1 (EMBL:AE006627) (498 aa) fasta scores: E()=6.1e-62, 46.843% id in 491 aa
YP_003027071.1	with TehA confers resistance to tellurite
YP_003027073.1	binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation
YP_003027076.1	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif
YP_003027079.1	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases
YP_003027080.1	Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome
YP_003027085.1	Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate
YP_003027090.1	C-terminal region is similar to Escherichia coli O157:H7 ferrous iron transport protein A FeoA UniProt:P33649 (EMBL:AE005174) (75 aa) fasta scores: E()=0.62, 35.185% id in 54 aa. Full length CDS is similar to Streptococcus thermophilus (strain CNRZ 1066) ferrous iron transport protein A FeoA UniProt:Q5M0Q1 (EMBL:CP000024) (158 aa) fasta scores: E()=2.9e-20, 53.285% id in 137 aa, and
YP_003027092.1	Possible alternative translational start site after codon 3
YP_003027094.1	recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1
YP_003027104.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium
YP_003027105.1	synthesizes RNA primers at the replication forks
YP_003027108.1	a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA
YP_003027113.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_003027115.1	catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate
YP_003027116.1	catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation
YP_003027118.1	catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose
YP_003027119.1	Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway
YP_003027123.1	in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE
YP_003027131.1	divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases
YP_003027132.1	involved in the import of serine and threonine coupled with the import of sodium
YP_003027133.1	Possible gene remnant. Similar to the C-terminal region Staphylococcus aureus probable glutamyl-endopeptidase UniProt:Q8GAX7 (EMBL:AB057421) (232 aa) fasta scores: E()=0.24, 29.412% id in 85 aa
YP_003027138.1	catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YP_003027139.1	Possible gene remnant. CDS is truncated at the C-terminus in comparison to orthologues. Similar to Streptococcus pyogenes serotype M18 hypothetical protein SPYM18_1019 UniProt:Q7CN97 (EMBL:AE010030) (318 aa) fasta scores: E()=1.2e-29, 44.545% id in 220 aa
YP_003027145.1	Doubtful CDS
YP_003027147.1	Possible gene remnant. N-terminal region is similar to Streptococcus thermophilus (strain CNRZ 1066) hypothetical protein UniProt:Q5LZH0 (EMBL:CP000024) (90 aa) fasta scores: E()=2.1e-07, 40.000% id in 90 aa
YP_003027159.1	Previously sequenced as Streptococcus suis fibronectin/fibrinogen binding protein FbpS UniProt:Q8RP86 (EMBL:AF438158) (552 aa) fasta scores: E()=8.7e-190, 99.638% id in 552 aa
YP_003027166.1	Similar to SU0572, 51.765% identity (51.765% ungapped) in 85 aa overlap (2-86:3-87)
YP_003027168.1	enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis
YP_003027174.1	acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation
YP_003027175.1	negatively supercoils closed circular double-stranded DNA
YP_003027180.1	Similar to the C-terminal region of bacteriophage P4 alpha P4-specific DNA primase UniProt:P10277 (EMBL:MYP4ALPH) (777 aa) fasta scores: E()=2.6e-06, 21.140% id in 421 aa
YP_003027185.1	Similar to Staphylococcus aureus pathogenicity island protein Orf18 UniProt:Q9F0K0 (EMBL:AF217235) (86 aa) fasta scores: E()=1.5e-05, 39.024% id in 82 aa
YP_003027196.1	RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_003027205.1	required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA
YP_003027214.1	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_003027215.1	Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate
YP_003027224.1	catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine
YP_003027241.1	enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine
YP_003027244.1	forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis
YP_003027247.1	Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_003027258.1	associated with arginine deiminase pathway genes; probably functions in arginine catabolism
YP_003027265.1	transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein
YP_003027266.1	catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system
YP_003027269.1	Identical to SSU0567, 100.000% identity (100.000% ungapped) in 159 aa overlap (1-159:1-159), SSU0967, 100.000% identity (100.000% ungapped) in 159 aa overlap (1-159:1-159), and SSU0542, 100.000% identity (100.000% ungapped) in 159 aa overlap (1-159:1-159)
YP_003027276.1	catalyzes the removal of N-terminal amino acids from peptides and arylamides
YP_003027278.1	adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active
YP_003027280.1	catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase
YP_003027284.1	catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon
YP_003027286.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA
YP_003027290.1	functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor
YP_003027294.1	2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate
YP_003027297.1	CDS is extended at the C-terminus in comparison to orthologues, possibly due to the insertion of the downstream IS element. Similar to Streptococcus pneumoniae (strain ATCC BAA-255/R6) mvaa 3-hydroxy-3-methylglutaryl-coenzyme a reductase (ec 1.1.1.88). UniProt:Q8DNS5 (EMBL:AE008524) (424 aa) fasta scores: E()=1.1e-93, 60.952% id in 420 aa
YP_003027309.1	catalyzes the bidirectional exonucleolytic cleavage of DNA
YP_003027310.1	bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides
YP_003027317.1	catalyzes the hydrolysis of pyrophosphate to phosphate
YP_003027324.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate
YP_003027325.1	catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers
YP_003027327.1	23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance
YP_003027330.1	Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA
YP_003027339.1	Previously sequenced as Streptococcus suis Dps-like peroxide resistance protein Dpr UniProt:Q9F5J9 (EMBL:AF319974) (172 aa) fasta scores: E()=3.9e-61, 100.000% id in 172 aa
YP_003027350.1	functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer
YP_003027351.1	functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB
YP_003027352.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_003027355.1	HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine
YP_003027356.1	converts L-glutamate to D-glutamate, a component of peptidoglycan
YP_003027363.1	catalyzes the hydrolysis of acylphosphate
YP_003027365.1	necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_003027368.1	Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis
YP_003027373.1	EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains
YP_003027374.1	Primosomal protein that may act to load helicase DnaC during DNA replication
YP_003027379.1	catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate
YP_003027385.1	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YP_003027398.1	Similar to the N-terminal region of Enterococcus faecalis (Streptococcus faecalis) Cad sex pheromone Cad1 lipoprotein precursor UniProt:Q8RP94 (EMBL:AF421355) (309 aa) fasta scores: E()=6.3e-15, 41.899% id in 179 aa
YP_003027408.1	glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_003027409.1	glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_003027410.1	Possible alternative translational start site after codon 28. C-terminal region is similar to Staphylococcus aureus (strain MW2) hypothetical protein MW0324 UniProt:Q8NY99 (EMBL:BA000033) (129 aa) fasta scores: E()=6.7e-21, 52.381% id in 126 aa
YP_003027417.1	catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine
YP_003027433.1	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; these proteins present a shorter N-terminus
YP_003027434.1	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits
YP_003027435.1	an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_003027436.1	in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP
YP_003027437.1	composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_003027438.1	FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP
YP_003027439.1	catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_003027442.1	carries the fatty acid chain in fatty acid biosynthesis
YP_003027443.1	FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs
YP_003027445.1	Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA
YP_003027447.1	catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive
YP_003027448.1	Doubtful CDS. No significant database matches
YP_003027449.1	converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer
YP_003027450.1	Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids
YP_003027451.1	functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins
YP_003027457.1	Regulates rRNA biosynthesis by transcriptional antitermination
YP_003027459.1	Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA
YP_003027461.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YP_003027464.1	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit
YP_003027465.1	binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA
YP_003027466.1	binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21
YP_003027475.1	Possible gene remnant. Similar to the C-terminal region of Treponema denticola hypothetical protein UniProt:Q73Q18 (EMBL:AE017248) (504 aa) fasta scores: E()=1.3e-17, 29.567% id in 416 aa
YP_003027477.1	associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock
YP_003027478.1	Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YP_003027481.1	modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination
YP_003027483.1	tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine
YP_003027506.1	enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence
YP_003027507.1	BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell
YP_003027509.1	Similar to SSU0447, 58.436% identity (58.678% ungapped) in 243 aa overlap (4-246:3-244); SSU0884, 55.000% identity (55.230% ungapped) in 240 aa overlap (7-246:6-244); SSU1851, 51.029% identity (52.321% ungapped) in 243 aa overlap (6-244:1-241); SSU1192, 46.091% identity (46.667% ungapped) in 243 aa overlap (6-246:3-244)
YP_003027512.1	catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic
YP_003027513.1	catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis
YP_003027514.1	with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit
YP_003027515.1	catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit
YP_003027519.1	catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis
YP_003027522.1	forms a direct contact with the tRNA during translation
YP_003027523.1	in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit
YP_003027544.1	Similar to an internal region of Microbacterium sp. M-90 alpha-1,2-mannosidase precursor AmaN2 UniProt:Q9WXI8 (EMBL:AB025248) (1976 aa) fasta scores: E()=2.3e-34, 29.262% id in 745 aa
YP_003027545.1	Similar to Streptococcus pneumoniae endo-beta-n-acetylglucosaminidase D UniProt:Q93HW0 (EMBL:AB055806) (1646 aa) fasta scores: E()=0, 55.369% id in 1369 aa, although there is a lack of similarity in the C-terminal regions
YP_003027547.1	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_003027556.1	primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence
YP_003027563.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_003027565.1	catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D
YP_003027566.1	Similar to Lactococcus lactis subsp. lactis (Streptococcus lactis) leuc 3-isopropylmalate dehydratase large subunit (ec 4.2.1.33 (isopropylmalate isomerase) (alpha-ipm isomerase) (ipmi). UniProt:Q02142 (EMBL:AE006354) (460 aa) fasta scores: E()=4.5e-107, 65.646% id in 457 aa
YP_003027567.1	catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis
YP_003027568.1	catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis
YP_003027572.1	Possible alternative upstream translational start sites. Similar to Clostridium tetani LemA-like protein UniProt:Q898T4 (EMBL:AE015937) (191 aa) fasta scores: E()=8.6e-05, 26.786% id in 168 aa
YP_003027573.1	catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity
YP_003027574.1	similar to DhaK; in Lactococcus lactis this protein froms a stable complex with DhaS and activates transcription of the dha operon in the presence of dihydroxyacetone
YP_003027576.1	with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase
YP_003027579.1	Similar to SSU0677, 57.576% identity (57.576% ungapped) in 231 aa overlap (3-233:6-236)
YP_003027580.1	catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro)
YP_003027583.1	catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate
YP_003027586.1	Synthesizes glutathione from L-glutamate and L-cysteine via gamma-L-glutamyl-L-cysteine
YP_003027587.1	Previously sequenced as Streptococcus suis DNA nuclease SsnA UniProt:Q6X5T7 (EMBL:AY254322) (1041 aa) fasta scores: E()=0, 98.369% id in 1042 aa. CDS contain a region of sequence divergence in comparison to previously sequenced CDS between codons 430 to 450
YP_003027588.1	becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers
YP_003027597.1	EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu
YP_003027598.1	one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit
YP_003027599.1	Weakly similar to Schistosoma mansoni (Blood fluke) adenylate kinase (ec 2.7.4.3) UniProt:P25824 (EMBL:SMNPK) (197 aa) fasta scores: E()=4.4, 22.857% id in 175 aa
YP_003027600.1	N-terminal region is similar to the N-terminus of Lactococcus lactis subsp. cremoris (Streptococcus cremoris) PII-type proteinase precursor Prt UniProt:P15293 (EMBL:SLPRT763) (1902 aa) fasta scores: E()=1.6e-43, 25.137% id in 1647 aa
YP_003027601.1	Modulates Rho-dependent transcription termination
YP_003027602.1	forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force
YP_003027603.1	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif
YP_003027613.1	EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity
YP_003027620.1	catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin
YP_003027630.1	in Escherichia coli transcription of this gene is enhanced by polyamines
YP_003027633.1	protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates
YP_003027634.1	catalyzes the formation of arginine from (N-L-arginino)succinate
YP_003027635.1	catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming
YP_003027640.1	converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines
YP_003027642.1	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation
YP_003027648.1	Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents
YP_003027650.1	catalyzes the formation of dUMP from dUTP
YP_003027654.1	catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate
YP_003027659.1	transferase
YP_003027661.1	N-terminus is similar to the N-terminal region of Lactobacillus johnsonii prophage LJ965 superinfection immunity protein UniProt:Q6SEA6 (EMBL:AY459535) (174 aa) fasta scores: E()=0.013, 39.706% id in 68 aa
YP_003027663.1	functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family
YP_003027666.1	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_003027670.1	catalyzes the formation of D-xylulose 5-phosphate from L-ribulose 5-phosphate in the L-arabinose and L-ascorbate degradation pathways
YP_003027671.1	L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate
YP_003027672.1	catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization
YP_003027675.1	membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr
YP_003027678.1	Similar to SSU0447, 58.436% identity (58.678% ungapped) in 243 aa overlap (4-246:3-244); SSU0884, 55.000% identity (55.230% ungapped) in 240 aa overlap (7-246:6-244); SSU1851, 51.029% identity (52.321% ungapped) in 243 aa overlap (6-244:1-241); SSU1192, 46.091% identity (46.667% ungapped) in 243 aa overlap (6-246:3-244)
YP_003027681.1	Possible gene remnant. Similar to the C_terminal regions of several proteins, including Streptococcus mutans secreted antigen GbpB/SagA UniProt:Q8DWM3 (EMBL:AE014855) (431 aa) fasta scores: E()=1.3e-26, 50.000% id in 172 aa
YP_003027688.1	Similar to SSU0176, 74.464% identity (74.464% ungapped) in 466 aa overlap (1-466:1-466)
YP_003027690.1	leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase
YP_003027700.1	Doubtful CDS, possible DNA repeat region. CDS is extended at the C-terminus in comparison to similar proteins, for example, similar to Streptococcus agalactiae serotype V hypothetical protein SAG1999 UniProt:Q8DX55 (EMBL:AE014282) (47 aa) fasta scores: E()=3.9e-12, 87.234% id in 47 aa
YP_003027702.1	hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine
YP_003027704.1	in Escherichia coli this is a periplasmic enzyme while in gram positive organisms it may be anchored at the cell surface; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate
YP_003027705.1	Previously sequenced as Streptococcus suis sortase-like protein SrtD UniProt:Q8VUP0 (EMBL:AB066354) (273 aa) fasta scores: E()=7.8e-88, 88.278% id in 273 aa
YP_003027706.1	Previously sequenced as Streptococcus suis srtc sortase-like protein. UniProt:Q8VUP1 (EMBL:AB066354) (285 aa) fasta scores: E()=4.3e-103, 100.000% id in 285 aa
YP_003027707.1	Previously sequenced as Streptococcus suis sortase-like protein SrtB UniProt:Q8VUP2 (EMBL:AB066354) (295 aa) fasta scores: E()=1.7e-106, 98.644% id in 295 aa
YP_003027709.1	Possible pseudogene. CDS lacks an N-terminal signal sequence. CDS is possible C-terminal region of large surface-anchored protein, downstrean CDS, SSU1889 is possible N-terminal region.
YP_003027711.1	Doubtful CDS
YP_003027712.1	in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase
YP_003027713.1	methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype
YP_003027718.1	CDS is truncated at the C-terminus in comparison to some orthologues, for example, similar to Streptococcus pneumoniae anaerobic ribonucleoside-triphosphate reductase activatin protein. UniProt:Q97SV9 (EMBL:AE007335) (196 aa) fasta scores: E()=2.5e-65, 89.617% id in 183 aa
YP_003027722.1	Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates
YP_003027723.1	Similar to SSU0053, 88.809% identity (88.809% ungapped) in 277 aa overlap (153-429:36-312)
YP_003027727.1	This protein performs the mismatch recognition step during the DNA repair process
YP_003027729.1	catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase
YP_003027730.1	CDS is truncated at the C-terminus in comparison to several proteins, for example, similar to Streptococcus pneumoniae choline binding protein D CbpD UniProt:Q9KGZ2 (EMBL:AE007508) (448 aa) fasta scores: E()=6.8e-50, 44.013% id in 309 aa
YP_003027733.1	amylomaltase; acts to release glucose from maltodextrins
YP_003027742.1	catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes
YP_003027746.1	Similar to Clostridium thermocellum thermostable beta-glucosidase B BglB (ec 3.2.1.21) (gentiobiase (cellobiase) (beta-d-glucoside glucohydrolase). UniProt:P14002 (EMBL:CTBGLB) (754 aa) fasta scores: E()=1.3e-95, 45.545% id in 707 aa. Lower levels of similarity in the C-terminal regions
YP_003027752.1	Reduces fumarate to succinate in anaerobic bacterial respiration
YP_003027754.1	primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination
YP_003027757.1	unwinds double stranded DNA
YP_003027758.1	in Escherichia coli this protein is wrapped around the base of the L1 stalk
YP_003027760.1	GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs
YP_003027761.1	Similar to SSU1944, 52.381% identity (52.381% ungapped) in 147 aa overlap (1-147:1-147)
YP_003027763.1	Similar to SSU1942, 52.381% identity (52.381% ungapped) in 147 aa overlap (1-147:1-147)
YP_003027766.1	catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs
YP_003027771.1	with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene
YP_003027772.1	with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene
YP_003027778.1	Required for DNA replication; binds preferentially to single-stranded, linear DNA
YP_003027779.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_003027780.1	catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_003027785.1	SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA
YP_003027786.1	Possible alternative translational start site after codon 6