-- dump date 20111121_015057 -- class Genbank::misc_feature -- table misc_feature_note -- id note 218494000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 218494000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218494000003 Walker A motif; other site 218494000004 ATP binding site [chemical binding]; other site 218494000005 Walker B motif; other site 218494000006 arginine finger; other site 218494000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 218494000008 DnaA box-binding interface [nucleotide binding]; other site 218494000009 HMMPfam hit to PF00308, Chromosomal replication initiator, DnaA, score 6e-111 218494000010 PS00017 ATP/GTP-binding site motif A (P-loop). 218494000011 HMMPfam hit to PF08299, Chromosomal replication initiator, DnaA C-terminal, score 3.9e-33 218494000012 PS01008 DnaA protein signature. 218494000013 DNA polymerase III subunit beta; Validated; Region: PRK05643 218494000014 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 218494000015 putative DNA binding surface [nucleotide binding]; other site 218494000016 dimer interface [polypeptide binding]; other site 218494000017 beta-clamp/clamp loader binding surface; other site 218494000018 beta-clamp/translesion DNA polymerase binding surface; other site 218494000019 HMMPfam hit to PF00712, DNA polymerase III, beta chain, score 1.1e-25 218494000020 HMMPfam hit to PF02767, DNA polymerase III, beta chain, score 5e-39 218494000021 HMMPfam hit to PF02768, DNA polymerase III, beta chain, score 3.8e-33 218494000022 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 218494000023 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 218494000024 HMMPfam hit to PF00781, Diacylglycerol kinase, catalytic region, score 1.7e-11 218494000025 PS00070 Aldehyde dehydrogenases cysteine active site. 218494000026 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 218494000027 HMMPfam hit to PF06107, Protein of unknown function DUF951, bacterial, score 4e-44 218494000028 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218494000029 non-specific DNA binding site [nucleotide binding]; other site 218494000030 salt bridge; other site 218494000031 sequence-specific DNA binding site [nucleotide binding]; other site 218494000032 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 5.4e-21 218494000033 Predicted helix-turn-helix motif with score 2317.000, SD 7.08 at aa 17-38, sequence LSQDELAEKLYISRQAVSKWEN 218494000034 1 probable transmembrane helix predicted for SSU0005 by TMHMM2.0 at aa 99-118 218494000035 GTP-binding protein YchF; Reviewed; Region: PRK09601 218494000036 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 218494000037 G1 box; other site 218494000038 GTP/Mg2+ binding site [chemical binding]; other site 218494000039 Switch I region; other site 218494000040 G2 box; other site 218494000041 Switch II region; other site 218494000042 G3 box; other site 218494000043 G4 box; other site 218494000044 G5 box; other site 218494000045 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 218494000046 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 4.1e-34 218494000047 PS00017 ATP/GTP-binding site motif A (P-loop). 218494000048 HMMPfam hit to PF06071, Protein of unknown function DUF933, score 6.4e-62 218494000049 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 218494000050 putative active site [active] 218494000051 catalytic residue [active] 218494000052 HMMPfam hit to PF01195, Peptidyl-tRNA hydrolase, score 4.1e-79 218494000053 PS01196 Peptidyl-tRNA hydrolase signature 2. 218494000054 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 218494000055 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 218494000056 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218494000057 ATP binding site [chemical binding]; other site 218494000058 putative Mg++ binding site [ion binding]; other site 218494000059 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218494000060 nucleotide binding region [chemical binding]; other site 218494000061 ATP-binding site [chemical binding]; other site 218494000062 TRCF domain; Region: TRCF; cl04088 218494000063 HMMPfam hit to PF02559, Transcription factor CarD, score 2.4e-52 218494000064 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 5.2e-41 218494000065 PS00017 ATP/GTP-binding site motif A (P-loop). 218494000066 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 2.4e-19 218494000067 HMMPfam hit to PF03461, TRCF, score 5.3e-36 218494000068 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 218494000069 HMMPfam hit to PF01479, RNA-binding S4, score 8.9e-10 218494000070 Septum formation initiator; Region: DivIC; cl11433 218494000071 1 probable transmembrane helix predicted for SSU0010 by TMHMM2.0 at aa 38-60 218494000072 HMMPfam hit to PF04977, Septum formation initiator, score 3.6e-16 218494000073 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 218494000074 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 218494000075 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 218494000076 Ligand Binding Site [chemical binding]; other site 218494000077 B3/4 domain; Region: B3_4; cl11458 218494000078 HMMPfam hit to PF01171, PP-loop, score 1.4e-78 218494000079 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 218494000080 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 1.6e-29 218494000081 FtsH Extracellular; Region: FtsH_ext; pfam06480 218494000082 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 218494000083 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218494000084 Walker A motif; other site 218494000085 ATP binding site [chemical binding]; other site 218494000086 Walker B motif; other site 218494000087 arginine finger; other site 218494000088 Peptidase family M41; Region: Peptidase_M41; pfam01434 218494000089 2 probable transmembrane helices predicted for SSU0015 by TMHMM2.0 at aa 15-33 and 135-157 218494000090 HMMPfam hit to PF06480, Peptidase M41, FtsH extracellular, score 1.4e-30 218494000091 HMMPfam hit to PF00004, AAA ATPase, core, score 4.9e-98 218494000092 PS00017 ATP/GTP-binding site motif A (P-loop). 218494000093 PS00674 AAA-protein family signature. 218494000094 HMMPfam hit to PF01434, Peptidase M41, score 2.2e-104 218494000095 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 218494000096 rod shape-determining protein MreC; Provisional; Region: PRK14872 218494000097 rod shape-determining protein MreC; Region: MreC; pfam04085 218494000098 1 probable transmembrane helix predicted for SSU0018 by TMHMM2.0 at aa 7-26 218494000099 HMMPfam hit to PF04085, Rod shape-determining protein MreC, score 1.4e-31 218494000100 5 probable transmembrane helices predicted for SSU0019 by TMHMM2.0 at aa 5-27, 47-69, 74-96, 106-128 and 135-157 218494000101 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 218494000102 NlpC/P60 family; Region: NLPC_P60; cl11438 218494000103 HMMPfam hit to PF05257, Cysteine, histidine-dependent amidohydrolase/peptidase, score 8e-36 218494000104 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 218494000105 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 218494000106 PS00114 Phosphoribosyl pyrophosphate synthetase signature. 218494000107 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 5.3e-31 218494000108 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 218494000109 aromatic amino acid aminotransferase; Validated; Region: PRK07309 218494000110 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218494000111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218494000112 homodimer interface [polypeptide binding]; other site 218494000113 catalytic residue [active] 218494000114 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 2.6e-56 218494000115 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 218494000116 Recombination protein O N terminal; Region: RecO_N; pfam11967 218494000117 DNA repair protein RecO; Region: reco; TIGR00613 218494000118 Recombination protein O C terminal; Region: RecO_C; pfam02565 218494000119 HMMPfam hit to PF02565, Recombination protein O, RecO, score 1.8e-19 218494000120 PS00190 Cytochrome c family heme-binding site signature. 218494000121 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 218494000122 HMMPfam hit to PF02504, Fatty acid synthesis plsX protein, score 4.9e-135 218494000123 Phosphopantetheine attachment site; Region: PP-binding; cl09936 218494000124 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 218494000125 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 218494000126 ATP binding site [chemical binding]; other site 218494000127 active site 218494000128 substrate binding site [chemical binding]; other site 218494000129 HMMPfam hit to PF01259, SAICAR synthetase, score 5e-118 218494000130 PS01057 SAICAR synthetase signature 1. 218494000131 PS01058 SAICAR synthetase signature 2. 218494000132 PS00012 Phosphopantetheine attachment site. 218494000133 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 218494000134 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 218494000135 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 218494000136 dimerization interface [polypeptide binding]; other site 218494000137 ATP binding site [chemical binding]; other site 218494000138 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 218494000139 dimerization interface [polypeptide binding]; other site 218494000140 ATP binding site [chemical binding]; other site 218494000141 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 218494000142 putative active site [active] 218494000143 catalytic triad [active] 218494000144 HMMPfam hit to PF00586, AIR synthase related protein, score 5.1e-05 218494000145 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal, score 5e-35 218494000146 PS01159 WW/rsp5/WWP domain signature. 218494000147 amidophosphoribosyltransferase; Provisional; Region: PRK07272 218494000148 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 218494000149 active site 218494000150 tetramer interface [polypeptide binding]; other site 218494000151 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 218494000152 PS00443 Glutamine amidotransferases class-II active site. 218494000153 HMMPfam hit to PF00310, Glutamine amidotransferase, class-II, score 9.9e-43 218494000154 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 2.7e-07 218494000155 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 218494000156 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 218494000157 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 218494000158 dimerization interface [polypeptide binding]; other site 218494000159 putative ATP binding site [chemical binding]; other site 218494000160 HMMPfam hit to PF00586, AIR synthase related protein, score 2.4e-70 218494000161 HMMPfam hit to PF02769, AIR synthase related protein, C-terminal, score 1.8e-46 218494000162 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 218494000163 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 218494000164 active site 218494000165 substrate binding site [chemical binding]; other site 218494000166 cosubstrate binding site; other site 218494000167 catalytic site [active] 218494000168 HMMPfam hit to PF00551, Formyl transferase, N-terminal, score 1.4e-60 218494000169 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 218494000170 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 218494000171 purine monophosphate binding site [chemical binding]; other site 218494000172 dimer interface [polypeptide binding]; other site 218494000173 putative catalytic residues [active] 218494000174 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 218494000175 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 218494000176 HMMPfam hit to PF02142, MGS-like, score 4.4e-56 218494000177 HMMPfam hit to PF01808, AICARFT/IMPCHase bienzyme, formylation region, score 4.8e-148 218494000178 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 218494000179 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 218494000180 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 218494000181 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 218494000182 HMMPfam hit to PF02844, Phosphoribosylglycinamide synthetase, score 8.4e-44 218494000183 HMMPfam hit to PF01071, Phosphoribosylglycinamide synthetase, score 4e-119 218494000184 PS00184 Phosphoribosylglycinamide synthetase signature. 218494000185 HMMPfam hit to PF02843, Phosphoribosylglycinamide synthetase, score 3.2e-14 218494000186 AIR carboxylase; Region: AIRC; cl00310 218494000187 HMMPfam hit to PF00731, 1-(5-Phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase, score 1.7e-87 218494000188 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 218494000189 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 218494000190 HMMPfam hit to PF02222, ATP-grasp fold, ATP-dependent carboxylate-amine ligase-type, score 1.6e-66 218494000191 adenylosuccinate lyase; Provisional; Region: PRK07492 218494000192 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 218494000193 tetramer interface [polypeptide binding]; other site 218494000194 active site 218494000195 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 218494000196 HMMPfam hit to PF00206, Fumarate lyase, score 8.8e-91 218494000197 PS00163 Fumarate lyases signature. 218494000198 6 probable transmembrane helices predicted for SSU0039 by TMHMM2.0 at aa 17-39, 54-76, 104-126, 146-168, 175-197 and 212-231 218494000199 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 218494000200 5 probable transmembrane helices predicted for SSU0040 by TMHMM2.0 at aa 9-31, 35-57, 77-96, 129-151 and 160-182 218494000201 HMMPfam hit to PF02517, Abortive infection protein, score 1.9e-12 218494000202 4 probable transmembrane helices predicted for SSU0041 by TMHMM2.0 at aa 2-24, 28-50, 57-79 and 107-129 218494000203 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 218494000204 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494000205 Walker A/P-loop; other site 218494000206 ATP binding site [chemical binding]; other site 218494000207 Q-loop/lid; other site 218494000208 ABC transporter signature motif; other site 218494000209 Walker B; other site 218494000210 D-loop; other site 218494000211 H-loop/switch region; other site 218494000212 HMMPfam hit to PF00005, ABC transporter related, score 1.8e-47 218494000213 PS00017 ATP/GTP-binding site motif A (P-loop). 218494000214 PS00017 ATP/GTP-binding site motif A (P-loop). 218494000215 6 probable transmembrane helices predicted for SSU0043 by TMHMM2.0 at aa 20-42, 62-84, 104-126, 159-181, 188-210 and 225-244 218494000216 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 218494000217 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 218494000218 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494000219 Walker A/P-loop; other site 218494000220 ATP binding site [chemical binding]; other site 218494000221 Q-loop/lid; other site 218494000222 ABC transporter signature motif; other site 218494000223 Walker B; other site 218494000224 D-loop; other site 218494000225 H-loop/switch region; other site 218494000226 5 probable transmembrane helices predicted for SSU0044 by TMHMM2.0 at aa 17-39, 57-79, 124-143, 147-169 and 243-265 218494000227 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 6.8e-21 218494000228 HMMPfam hit to PF00005, ABC transporter related, score 7.5e-54 218494000229 PS00017 ATP/GTP-binding site motif A (P-loop). 218494000230 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 218494000231 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218494000232 Walker A motif; other site 218494000233 ATP binding site [chemical binding]; other site 218494000234 Walker B motif; other site 218494000235 arginine finger; other site 218494000236 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 218494000237 HMMPfam hit to PF05496, DNA helicase, Holliday junction RuvB type, N-terminal, score 5.7e-28 218494000238 HMMPfam hit to PF00004, AAA ATPase, core, score 7.1e-28 218494000239 PS00017 ATP/GTP-binding site motif A (P-loop). 218494000240 HMMPfam hit to PF05491, DNA helicase, Holliday junction RuvB type, C-terminal, score 1.5e-53 218494000241 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 218494000242 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.5e-05 218494000243 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 218494000244 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218494000245 motif II; other site 218494000246 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 8.8e-21 218494000247 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218494000248 non-specific DNA binding site [nucleotide binding]; other site 218494000249 salt bridge; other site 218494000250 sequence-specific DNA binding site [nucleotide binding]; other site 218494000251 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 7.6e-06 218494000252 Transposase; Region: DEDD_Tnp_IS110; pfam01548 218494000253 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 218494000254 HMMPfam hit to PF01548, Transposase, IS111A/IS1328/IS1533, score 1.6e-11 218494000255 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 5.9e-24 218494000256 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 218494000257 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 218494000258 HMMPfam hit to PF01609, Transposase, IS4-like, score 1.7e-05 218494000259 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 218494000260 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218494000261 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218494000262 HMMPfam hit to PF08245, Mur ligase, central, score 0.00013 218494000263 PS01012 Folylpolyglutamate synthase signature 2. 218494000264 HMMPfam hit to PF02875, Mur ligase, C-terminal, score 5.2e-05 218494000265 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 218494000266 9 probable transmembrane helices predicted for SSU0056 by TMHMM2.0 at aa 47-69, 90-112, 117-139, 152-183, 203-225, 237-259, 284-306, 319-341 and 378-397 218494000267 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 218494000268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218494000269 ATP binding site [chemical binding]; other site 218494000270 Mg2+ binding site [ion binding]; other site 218494000271 G-X-G motif; other site 218494000272 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 218494000273 ATP binding site [chemical binding]; other site 218494000274 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 218494000275 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 4.9e-10 218494000276 PS00058 DNA mismatch repair proteins mutL / hexB / PMS1 signature. 218494000277 HMMPfam hit to PF01119, DNA mismatch repair protein, C-terminal, score 9.7e-47 218494000278 HMMPfam hit to PF08676, MutL, C-terminal, dimerisation, score 2.6e-54 218494000279 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 218494000280 RuvA N terminal domain; Region: RuvA_N; pfam01330 218494000281 HMMPfam hit to PF01330, DNA helicase, Holliday junction RuvA type, domain I, bacterial, score 1.3e-29 218494000282 HMMPfam hit to PF07499, DNA helicase, Holliday junction RuvA type, C-terminal domain III, score 4.1e-08 218494000283 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 218494000284 HMMPfam hit to PF03352, Methyladenine glycosylase, score 5.6e-93 218494000285 competence damage-inducible protein A; Provisional; Region: PRK00549 218494000286 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 218494000287 putative MPT binding site; other site 218494000288 Competence-damaged protein; Region: CinA; cl00666 218494000289 HMMPfam hit to PF00994, Molybdopterin binding, score 2.6e-51 218494000290 HMMPfam hit to PF02464, CinA, C-terminal, score 0.00013 218494000291 recombinase A; Provisional; Region: recA; PRK09354 218494000292 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 218494000293 hexamer interface [polypeptide binding]; other site 218494000294 Walker A motif; other site 218494000295 ATP binding site [chemical binding]; other site 218494000296 Walker B motif; other site 218494000297 HMMPfam hit to PF00154, RecA, score 1.5e-239 218494000298 PS00017 ATP/GTP-binding site motif A (P-loop). 218494000299 PS00321 recA signature. 218494000300 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 218494000301 ArsC family; Region: ArsC; pfam03960 218494000302 putative catalytic residues [active] 218494000303 thiol/disulfide switch; other site 218494000304 HMMPfam hit to PF03960, Arsenate reductase and related, score 3.8e-49 218494000305 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 218494000306 HMMPfam hit to PF06135, Protein of unknown function DUF965, bacterial, score 1.9e-50 218494000307 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 218494000308 HMMPfam hit to PF03652, Resolvase, holliday junction-type, YqgF-like, score 2.2e-50 218494000309 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 218494000310 HMMPfam hit to PF06949, Protein of unknown function DUF1292, score 2.6e-50 218494000311 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 218494000312 HMMPfam hit to PF06042, Protein of unknown function DUF925, bacterial, score 2.3e-77 218494000313 Probable gene remnant. Weakly similar to an internal region of Streptococcus pneumoniae transcriptional regulator ComX2 UniProt:Q97CV2 (EMBL:AE007319) (159 aa) fasta scores: E()=0.0002, 35.802% id in 81 aa. Similar to an internal region of SSU0016, 68.421% identity (71.233% ungapped) in 76 aa overlap (15-87:55-130) 218494000314 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 218494000315 HMMPfam hit to PF00338, Ribosomal protein S10, score 1.4e-60 218494000316 PS00361 Ribosomal protein S10 signature. 218494000317 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 218494000318 HMMPfam hit to PF00297, Ribosomal protein L3, score 3.1e-94 218494000319 PS00474 Ribosomal protein L3 signature. 218494000320 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 218494000321 HMMPfam hit to PF00573, Ribosomal protein L4/L1e, score 5.7e-76 218494000322 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 218494000323 HMMPfam hit to PF00276, Ribosomal protein L25/L23, score 2.1e-31 218494000324 PS00050 Ribosomal protein L23 signature. 218494000325 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 218494000326 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 218494000327 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 218494000328 HMMPfam hit to PF00181, Ribosomal protein L2, score 2.6e-47 218494000329 HMMPfam hit to PF03947, Ribosomal protein L2, score 1.3e-86 218494000330 PS00467 Ribosomal protein L2 signature. 218494000331 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 218494000332 HMMPfam hit to PF00203, Ribosomal protein S19/S15, score 3.2e-51 218494000333 PS00323 Ribosomal protein S19 signature. 218494000334 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 218494000335 putative translocon binding site; other site 218494000336 protein-rRNA interface [nucleotide binding]; other site 218494000337 HMMPfam hit to PF00237, Ribosomal protein L22/L17, score 1.3e-59 218494000338 PS00464 Ribosomal protein L22 signature. 218494000339 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 218494000340 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 218494000341 G-X-X-G motif; other site 218494000342 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 218494000343 HMMPfam hit to PF00417, Ribosomal protein S3, N-terminal, score 3.8e-28 218494000344 HMMPfam hit to PF07650, K Homology, type 2, score 1.4e-22 218494000345 HMMPfam hit to PF00189, Ribosomal protein S3, C-terminal, score 1e-50 218494000346 PS00548 Ribosomal protein S3 signature. 218494000347 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 218494000348 23S rRNA interface [nucleotide binding]; other site 218494000349 5S rRNA interface [nucleotide binding]; other site 218494000350 putative antibiotic binding site [chemical binding]; other site 218494000351 L25 interface [polypeptide binding]; other site 218494000352 L27 interface [polypeptide binding]; other site 218494000353 HMMPfam hit to PF00252, Ribosomal protein L16, score 2.6e-80 218494000354 PS00586 Ribosomal protein L16 signature 1. 218494000355 PS00701 Ribosomal protein L16 signature 2. 218494000356 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cl09943 218494000357 HMMPfam hit to PF00831, Ribosomal protein L29, score 1.2e-28 218494000358 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 218494000359 HMMPfam hit to PF00366, Ribosomal protein S17, score 6.2e-37 218494000360 PS00056 Ribosomal protein S17 signature. 218494000361 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 218494000362 HMMPfam hit to PF00238, Ribosomal protein L14b/L23e, score 7e-77 218494000363 PS00049 Ribosomal protein L14 signature. 218494000364 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 218494000365 KOW motif; Region: KOW; cl00354 218494000366 HMMPfam hit to PF00467, KOW, score 5.5e-08 218494000367 PS01108 Ribosomal protein L24 signature. 218494000368 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 218494000369 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 218494000370 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 218494000371 HMMPfam hit to PF00281, Ribosomal protein L5, score 7.5e-30 218494000372 PS00358 Ribosomal protein L5 signature. 218494000373 HMMPfam hit to PF00673, Ribosomal protein L5, score 2.1e-52 218494000374 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 218494000375 HMMPfam hit to PF00253, Ribosomal protein S14, score 3.6e-18 218494000376 PS00527 Ribosomal protein S14 signature. 218494000377 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 218494000378 HMMPfam hit to PF00410, Ribosomal protein S8, score 5.8e-75 218494000379 PS00053 Ribosomal protein S8 signature. 218494000380 Possible gene remnant. N-terminus is similar to the N-terminal region of Streptococcus pyogenes (serotype M3) pure phosphoribosylaminoimidazole carboxylase I UniProt:Q8K8Y3 (EMBL:AE014136) (203 aa) fasta scores: E()=0.041, 81.250% id in 16 aa 218494000381 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 218494000382 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 218494000383 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 218494000384 HMMPfam hit to PF00347, Ribosomal protein L6, score 8.3e-24 218494000385 HMMPfam hit to PF00347, Ribosomal protein L6, score 1.8e-29 218494000386 PS00525 Ribosomal protein L6 signature 1. 218494000387 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 218494000388 5S rRNA interface [nucleotide binding]; other site 218494000389 L27 interface [polypeptide binding]; other site 218494000390 23S rRNA interface [nucleotide binding]; other site 218494000391 L5 interface [polypeptide binding]; other site 218494000392 HMMPfam hit to PF00861, Ribosomal protein L18/L5, score 1.3e-54 218494000393 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 218494000394 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 218494000395 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 218494000396 HMMPfam hit to PF00333, Ribosomal protein S5, N-terminal, score 1.2e-40 218494000397 PS00585 Ribosomal protein S5 signature. 218494000398 HMMPfam hit to PF03719, Ribosomal protein S5, C-terminal, score 4.3e-34 218494000399 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 218494000400 23S rRNA binding site [nucleotide binding]; other site 218494000401 HMMPfam hit to PF00327, Ribosomal protein L30, score 5.9e-16 218494000402 PS00634 Ribosomal protein L30 signature. 218494000403 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 218494000404 HMMPfam hit to PF01305, Ribosomal protein L15, score 6.1e-61 218494000405 HMMPfam hit to PF00256, Ribosomal protein L15, score 3e-11 218494000406 PS00475 Ribosomal protein L15 signature. 218494000407 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 218494000408 SecY translocase; Region: SecY; pfam00344 218494000409 10 probable transmembrane helices predicted for SSU0093 by TMHMM2.0 at aa 20-42, 66-88, 116-138, 148-169, 176-198, 218-237, 269-291, 315-332, 366-388 and 398-416 218494000410 HMMPfam hit to PF00344, SecY protein, score 5.8e-152 218494000411 PS00755 Protein secY signature 1. 218494000412 adenylate kinase; Reviewed; Region: adk; PRK00279 218494000413 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 218494000414 AMP-binding site [chemical binding]; other site 218494000415 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 218494000416 HMMPfam hit to PF00406, Adenylate kinase, score 1.1e-89 218494000417 PS00113 Adenylate kinase signature. 218494000418 HMMPfam hit to PF05191, Adenylate kinase, lid region, score 0.0003 218494000419 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 218494000420 rRNA binding site [nucleotide binding]; other site 218494000421 predicted 30S ribosome binding site; other site 218494000422 HMMPfam hit to PF01176, S1, IF1 type, score 1.1e-34 218494000423 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 218494000424 HMMPfam hit to PF00444, Ribosomal protein L36, score 3.1e-17 218494000425 PS00828 Ribosomal protein L36 signature. 218494000426 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 218494000427 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 218494000428 HMMPfam hit to PF00416, Ribosomal protein S13, score 4.2e-55 218494000429 PS00646 Ribosomal protein S13 signature. 218494000430 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 218494000431 HMMPfam hit to PF00411, Ribosomal protein S11, score 5.4e-72 218494000432 PS00054 Ribosomal protein S11 signature. 218494000433 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 218494000434 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 218494000435 alphaNTD homodimer interface [polypeptide binding]; other site 218494000436 alphaNTD - beta interaction site [polypeptide binding]; other site 218494000437 alphaNTD - beta' interaction site [polypeptide binding]; other site 218494000438 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 218494000439 HMMPfam hit to PF01193, RNA polymerase, dimerisation, score 3.3e-26 218494000440 HMMPfam hit to PF01000, RNA polymerase, insert, score 1.1e-56 218494000441 HMMPfam hit to PF03118, RNA polymerase, alpha subunit, C-terminal, score 2e-30 218494000442 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 218494000443 HMMPfam hit to PF01196, Ribosomal protein L17, score 3.2e-62 218494000444 PS01167 Ribosomal protein L17 signature. 218494000445 genomic island 218494000446 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 218494000447 Phage integrase family; Region: Phage_integrase; pfam00589 218494000448 Int/Topo IB signature motif; other site 218494000449 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 1.6e-23 218494000450 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 218494000451 Replication initiation factor; Region: Rep_trans; pfam02486 218494000452 HMMPfam hit to PF02486, Replication initiation factor, score 4.4e-11 218494000453 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494000454 PS00327 Bacterial rhodopsins retinal binding site. 218494000455 HMMPfam hit to PF01580, Cell divisionFtsK/SpoIIIE, score 3.5e-06 218494000456 PS00017 ATP/GTP-binding site motif A (P-loop). 218494000457 1 probable transmembrane helix predicted for SSU0106 by TMHMM2.0 at aa 13-35 218494000458 2 probable transmembrane helices predicted for SSU0107 by TMHMM2.0 at aa 5-23 and 33-55 218494000459 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 218494000460 Probable gene remnant. Similar to the C-terminal region of Streptococcus mutans tyrosine recombinase XerC UniProt:O69155 (EMBL:AE014942) (356 aa) fasta scores: E()=0.00011, 27.717% id in 184 aa 218494000461 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 5.3e-10 218494000462 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494000463 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 1.5e-13 218494000464 Predicted helix-turn-helix motif with score 1850.000, SD 5.49 at aa 54-75, sequence YTNTEIAKELNVSQAAITKATK 218494000465 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 218494000466 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 218494000467 HMMPfam hit to PF00005, ABC transporter related, score 3.7e-45 218494000468 PS00211 ABC transporters family signature. 218494000469 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218494000470 ABC-ATPase subunit interface; other site 218494000471 dimer interface [polypeptide binding]; other site 218494000472 putative PBP binding regions; other site 218494000473 HMMPfam hit to PF00950, ABC-3, score 2.3e-102 218494000474 7 probable transmembrane helices predicted for SSU0114 by TMHMM2.0 at aa 15-35, 56-78, 88-107, 136-158, 178-200, 221-243 and 248-265 218494000475 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 218494000476 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 218494000477 metal binding site [ion binding]; metal-binding site 218494000478 YodA lipocalin-like domain; Region: YodA; cl01365 218494000479 HMMPfam hit to PF01297, Periplasmic solute binding protein, score 9.6e-101 218494000480 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494000481 HMMPfam hit to PF09223, YodA, score 2e-136 218494000482 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 218494000483 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494000484 HMMPfam hit to PF03965, Penicillinase repressor, score 5e-36 218494000485 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 218494000486 metal-binding site [ion binding] 218494000487 HMMPfam hit to PF00403, Heavy metal transport/detoxification protein, score 4.9e-08 218494000488 PS01047 Heavy-metal-associated domain. 218494000489 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 218494000490 nucleotide binding site/active site [active] 218494000491 HIT family signature motif; other site 218494000492 catalytic residue [active] 218494000493 HMMPfam hit to PF01230, Histidine triad (HIT) protein, score 5e-06 218494000494 PS00190 Cytochrome c family heme-binding site signature. 218494000495 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 218494000496 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 218494000497 active site 218494000498 HIGH motif; other site 218494000499 dimer interface [polypeptide binding]; other site 218494000500 KMSKS motif; other site 218494000501 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218494000502 RNA binding surface [nucleotide binding]; other site 218494000503 HMMPfam hit to PF01479, RNA-binding S4, score 4.9e-10 218494000504 PS00287 Cysteine proteases inhibitors signature. 218494000505 HMMPfam hit to PF00579, Aminoacyl-tRNA synthetase, class Ib, score 2.6e-110 218494000506 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218494000507 Transglycosylase; Region: Transgly; cl07896 218494000508 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 218494000509 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 218494000510 1 probable transmembrane helix predicted for SSU0121 by TMHMM2.0 at aa 37-59 218494000511 HMMPfam hit to PF00912, Glycosyl transferase, family 51, score 2.8e-79 218494000512 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 1.8e-24 218494000513 PS00237 G-protein coupled receptors signature. 218494000514 Possible gene remnant. Similar to an internal region of Streptococcus pyogenes (serotype M3) pure phosphoribosylaminoimidazole carboxylase I UniProt:Q8K8Y3 (EMBL:AE014136) (203 aa) fasta scores: E()=0.041, 81.250% id in 16 aa 218494000515 Probable gene remnant. Similar to the N-terminal region of Streptococcus pyogenes (serotype M6) hypothetical protein UniProt:Q5XCE9 (EMBL:CP000003) (95 aa) fasta scores: E()=9.1e-06, 71.875% id in 32 aa 218494000516 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 218494000517 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 218494000518 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 218494000519 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 218494000520 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 218494000521 RPB1 interaction site [polypeptide binding]; other site 218494000522 RPB10 interaction site [polypeptide binding]; other site 218494000523 RPB11 interaction site [polypeptide binding]; other site 218494000524 RPB3 interaction site [polypeptide binding]; other site 218494000525 RPB12 interaction site [polypeptide binding]; other site 218494000526 HMMPfam hit to PF04563, RNA polymerase, beta subunit, protrusion, score 1e-49 218494000527 HMMPfam hit to PF04561, RNA polymerase Rpb2, domain 2, score 2.1e-15 218494000528 HMMPfam hit to PF04561, RNA polymerase Rpb2, domain 2, score 1.4e-13 218494000529 HMMPfam hit to PF04565, RNA polymerase Rpb2, domain 3, score 4.7e-40 218494000530 HMMPfam hit to PF00562, RNA polymerase Rpb2, domain 6, score 9e-215 218494000531 PS01166 RNA polymerases beta chain signature. 218494000532 HMMPfam hit to PF04560, RNA polymerase Rpb2, domain 7, score 2.9e-49 218494000533 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 218494000534 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 218494000535 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 218494000536 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 218494000537 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 218494000538 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 218494000539 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 218494000540 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 218494000541 DNA binding site [nucleotide binding] 218494000542 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 218494000543 HMMPfam hit to PF04997, RNA polymerase Rpb1, domain 1, score 1e-150 218494000544 HMMPfam hit to PF00623, RNA polymerase, alpha subunit, score 3.3e-83 218494000545 HMMPfam hit to PF04983, RNA polymerase Rpb1, domain 3, score 1.8e-68 218494000546 HMMPfam hit to PF05000, RNA polymerase Rpb1, domain 4, score 1e-25 218494000547 HMMPfam hit to PF04998, RNA polymerase Rpb1, domain 5, score 4.1e-79 218494000548 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 218494000549 HMMPfam hit to PF06279, Protein of unknown function DUF1033, score 8.7e-58 218494000550 CDS contains a frameshift after codon 204. Similar to Escherichia coli MccF microcin C7 self-immunity protein MccF UniProt:Q47511 (EMBL:ECPMC7A) (344 aa) fasta scores: E()=1.2e-10, 31.776% id in 321 aa 218494000551 HMMPfam hit to PF02016, Peptidase S66, LD-carboxypeptidase A, score 6e-99 218494000552 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218494000553 Type II/IV secretion system protein; Region: GSPII_E; pfam00437 218494000554 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494000555 Walker A motif; other site 218494000556 ATP binding site [chemical binding]; other site 218494000557 Walker B motif; other site 218494000558 HMMPfam hit to PF00437, Bacterial type II secretion system protein E, score 2.5e-38 218494000559 PS00017 ATP/GTP-binding site motif A (P-loop). 218494000560 PS00662 Bacterial type II secretion system protein E signature. 218494000561 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 218494000562 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 218494000563 HMMPfam hit to PF00482, Bacterial type II secretion system protein, score 4.6e-13 218494000564 3 probable transmembrane helices predicted for SSU0127 by TMHMM2.0 at aa 99-121, 141-163 and 294-316 218494000565 HMMPfam hit to PF00482, Bacterial type II secretion system protein, score 3.8e-19 218494000566 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 218494000567 HMMPfam hit to PF07963, Prepilin-type cleavage/methylation, N-terminal, score 7.4e-07 218494000568 PS00409 Prokaryotic N-terminal methylation site. 218494000569 1 probable transmembrane helix predicted for SSU0128 by TMHMM2.0 at aa 13-35 218494000570 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 218494000571 1 probable transmembrane helix predicted for SSU0130 by TMHMM2.0 at aa 5-22 218494000572 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 218494000573 1 probable transmembrane helix predicted for SSU0132 by TMHMM2.0 at aa 9-31 218494000574 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 218494000575 PS00211 ABC transporters family signature. 218494000576 Acetokinase family; Region: Acetate_kinase; cl01029 218494000577 HMMPfam hit to PF00871, Acetate and butyrate kinase, score 8.3e-199 218494000578 PS01076 Acetate and butyrate kinases family signature 2. 218494000579 4 probable transmembrane helices predicted for SSU0135 by TMHMM2.0 at aa 10-32, 44-66, 76-98 and 110-132 218494000580 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 218494000581 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218494000582 PS01012 Folylpolyglutamate synthase signature 2. 218494000583 HMMPfam hit to PF02875, Mur ligase, C-terminal, score 0.0047 218494000584 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 218494000585 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 218494000586 metal binding site [ion binding]; metal-binding site 218494000587 HMMPfam hit to PF05343, Peptidase M42, score 8e-128 218494000588 1 probable transmembrane helix predicted for SSU0139 by TMHMM2.0 at aa 7-25 218494000589 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 218494000590 catalytic residues [active] 218494000591 HMMPfam hit to PF00085, Thioredoxin domain, score 3e-05 218494000592 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 218494000593 HMMPfam hit to PF06207, Protein of unknown function DUF1002, score 4.5e-47 218494000594 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 218494000595 putative tRNA-binding site [nucleotide binding]; other site 218494000596 HMMPfam hit to PF01588, tRNA-binding region, score 3.8e-22 218494000597 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 218494000598 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 218494000599 dimer interface [polypeptide binding]; other site 218494000600 ssDNA binding site [nucleotide binding]; other site 218494000601 tetramer (dimer of dimers) interface [polypeptide binding]; other site 218494000602 HMMPfam hit to PF00436, Primosome PriB/single-strand DNA-binding, score 1.1e-26 218494000603 1 probable transmembrane helix predicted for SSU0145 by TMHMM2.0 at aa 22-44 218494000604 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 218494000605 oligomerisation interface [polypeptide binding]; other site 218494000606 mobile loop; other site 218494000607 roof hairpin; other site 218494000608 HMMPfam hit to PF00166, Chaperonin Cpn10, score 5.2e-28 218494000609 PS00681 Chaperonins cpn10 signature. 218494000610 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 218494000611 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 218494000612 ring oligomerisation interface [polypeptide binding]; other site 218494000613 ATP/Mg binding site [chemical binding]; other site 218494000614 stacking interactions; other site 218494000615 hinge regions; other site 218494000616 HMMPfam hit to PF00118, Chaperonin Cpn60/TCP-1, score 7.5e-197 218494000617 PS00296 Chaperonins cpn60 signature. 218494000618 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 218494000619 S17 interaction site [polypeptide binding]; other site 218494000620 S8 interaction site; other site 218494000621 16S rRNA interaction site [nucleotide binding]; other site 218494000622 streptomycin interaction site [chemical binding]; other site 218494000623 23S rRNA interaction site [nucleotide binding]; other site 218494000624 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 218494000625 HMMPfam hit to PF00164, Ribosomal protein S12/S23, score 3e-65 218494000626 PS00055 Ribosomal protein S12 signature. 218494000627 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 218494000628 HMMPfam hit to PF00177, Ribosomal protein S7, score 1.8e-82 218494000629 PS00052 Ribosomal protein S7 signature. 218494000630 elongation factor G; Reviewed; Region: PRK00007 218494000631 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G; cd01886 218494000632 G1 box; other site 218494000633 putative GEF interaction site [polypeptide binding]; other site 218494000634 GTP/Mg2+ binding site [chemical binding]; other site 218494000635 Switch I region; other site 218494000636 G2 box; other site 218494000637 G3 box; other site 218494000638 Switch II region; other site 218494000639 G4 box; other site 218494000640 G5 box; other site 218494000641 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 218494000642 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 218494000643 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 218494000644 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 1.1e-114 218494000645 PS00017 ATP/GTP-binding site motif A (P-loop). 218494000646 PS00301 GTP-binding elongation factors signature. 218494000647 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 2.7e-18 218494000648 HMMPfam hit to PF03764, Translation elongation factor EFG/EF2, domain IV, score 6.3e-66 218494000649 HMMPfam hit to PF00679, Translation elongation factor EFG/EF2, C-terminal, score 2.9e-48 218494000650 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 218494000651 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 218494000652 active site 218494000653 Zn binding site [ion binding]; other site 218494000654 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494000655 HMMPfam hit to PF05649, Peptidase M13, score 9.3e-83 218494000656 HMMPfam hit to PF01431, Peptidase M13, neprilysin, score 3e-66 218494000657 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218494000658 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 218494000659 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 218494000660 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 218494000661 HMMPfam hit to PF00044, Glyceraldehyde 3-phosphate dehydrogenase, score 1.6e-79 218494000662 PS00071 Glyceraldehyde 3-phosphate dehydrogenase active site. 218494000663 HMMPfam hit to PF02800, Glyceraldehyde 3-phosphate dehydrogenase, score 1e-100 218494000664 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 218494000665 substrate binding site [chemical binding]; other site 218494000666 hinge regions; other site 218494000667 ADP binding site [chemical binding]; other site 218494000668 catalytic site [active] 218494000669 HMMPfam hit to PF00162, Phosphoglycerate kinase, score 6.6e-177 218494000670 PS00111 Phosphoglycerate kinase signature. 218494000671 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 218494000672 5 probable transmembrane helices predicted for SSU0155 by TMHMM2.0 at aa 13-35, 50-69, 76-98, 102-121 and 126-148 218494000673 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 218494000674 DNA binding residues [nucleotide binding] 218494000675 putative dimer interface [polypeptide binding]; other site 218494000676 HMMPfam hit to PF00376, Bacterial regulatory protein, MerR, score 5.5e-11 218494000677 PS00552 Bacterial regulatory proteins, merR family signature. 218494000678 glutamine synthetase, type I; Region: GlnA; TIGR00653 218494000679 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 218494000680 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 218494000681 HMMPfam hit to PF03951, Glutamine synthetase, beta-Grasp, score 1e-15 218494000682 PS00180 Glutamine synthetase signature 1. 218494000683 HMMPfam hit to PF00120, Glutamine synthetase, catalytic region, score 1.3e-149 218494000684 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 218494000685 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 218494000686 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 218494000687 HMMPfam hit to PF07521, RNA-metabolising metallo-beta-lactamase, score 3.7e-16 218494000688 PS01292 Uncharacterized protein family UPF0036 signature. 218494000689 HMMPfam hit to PF00753, Beta-lactamase-like, score 3.6e-30 218494000690 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 218494000691 HMMPfam hit to PF07288, Protein of unknown function DUF1447, score 4.5e-39 218494000692 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 218494000693 HMMPfam hit to PF00814, Peptidase M22, glycoprotease, score 1.4e-53 218494000694 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 218494000695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218494000696 Coenzyme A binding pocket [chemical binding]; other site 218494000697 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 3.1e-17 218494000698 UGMP family protein; Validated; Region: PRK09604 218494000699 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 218494000700 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 218494000701 HMMPfam hit to PF00814, Peptidase M22, glycoprotease, score 3.1e-77 218494000702 Cupin domain; Region: Cupin_2; cl09118 218494000703 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218494000704 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 218494000705 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218494000706 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 2.5e-12 218494000707 PS00041 Bacterial regulatory proteins, araC family signature. 218494000708 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 2.8e-11 218494000709 Predicted helix-turn-helix motif with score 1250.000, SD 3.44 at aa 192-213, sequence ISVDDLAQVCNLNRHYFSRLFK 218494000710 HMMPfam hit to PF02311, AraC protein, arabinose-binding/dimerisation, score 4.4e-22 218494000711 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218494000712 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 1.4e-40 218494000713 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494000714 PS00017 ATP/GTP-binding site motif A (P-loop). 218494000715 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 218494000716 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494000717 ABC-ATPase subunit interface; other site 218494000718 6 probable transmembrane helices predicted for SSU0165 by TMHMM2.0 at aa 12-34, 78-97, 110-129, 160-182, 203-225 and 266-285 218494000719 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.3e-12 218494000720 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218494000721 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 218494000722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494000723 dimer interface [polypeptide binding]; other site 218494000724 conserved gate region; other site 218494000725 ABC-ATPase subunit interface; other site 218494000726 6 probable transmembrane helices predicted for SSU0166 by TMHMM2.0 at aa 13-35, 78-100, 107-129, 139-161, 182-204 and 239-261 218494000727 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 3.9e-17 218494000728 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218494000729 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 218494000730 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 218494000731 catalytic site [active] 218494000732 HMMPfam hit to PF02065, Glycoside hydrolase, clan GH-D, score 1.8e-233 218494000733 PS00512 Alpha-galactosidase signature. 218494000734 AzlC protein; Region: AzlC; cl00570 218494000735 5 probable transmembrane helices predicted for SSU0168 by TMHMM2.0 at aa 13-35, 55-77, 134-156, 166-188 and 195-229 218494000736 HMMPfam hit to PF03591, AzlC-like, score 3.4e-60 218494000737 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 218494000738 4 probable transmembrane helices predicted for SSU0169 by TMHMM2.0 at aa 5-27, 40-57, 62-84 and 89-106 218494000739 HMMPfam hit to PF05437, Branched-chain amino acid transport, score 3.8e-31 218494000740 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 218494000741 HMMPfam hit to PF03601, hypothetical protein CHP00698, score 2.7e-90 218494000742 9 probable transmembrane helices predicted for SSU0170 by TMHMM2.0 at aa 21-43, 63-82, 87-106, 116-138, 151-173, 214-236, 249-271, 286-308 and 315-337 218494000743 N-terminal region is highly similar to previously sequenced as Streptococcus suis extracellular protein factor EF UniProt:Q07290 (EMBL:SSEPFAA) (1822 aa) fasta scores: E()=0, 75.041% id in 1222 aa. CDS contains a frameshift after codon 832, and a nonsense mutation (ochre) after codon 1033 218494000744 HMMPfam hit to PF04650, YSIRK Gram-positive signal peptide, score 1.4e-08 218494000745 1 probable transmembrane helix predicted for SSU0171 by TMHMM2.0 at aa 20-42 218494000746 HMMPfam hit to PF07564, Protein of unknown function DUF1542, score 1.2e-13 218494000747 HMMPfam hit to PF07564, Protein of unknown function DUF1542, score 4.7e-13 218494000748 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 1.4e-08 218494000749 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494000750 12 probable transmembrane helices predicted for SSU0173 by TMHMM2.0 at aa 51-73, 93-115, 148-170, 175-197, 209-228, 233-255, 332-351, 361-383, 421-440, 445-467, 480-497 and 507-529 218494000751 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 218494000752 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 218494000753 Walker A/P-loop; other site 218494000754 ATP binding site [chemical binding]; other site 218494000755 Q-loop/lid; other site 218494000756 ABC transporter signature motif; other site 218494000757 Walker B; other site 218494000758 D-loop; other site 218494000759 H-loop/switch region; other site 218494000760 HMMPfam hit to PF00005, ABC transporter related, score 9.8e-38 218494000761 PS00211 ABC transporters family signature. 218494000762 PS00017 ATP/GTP-binding site motif A (P-loop). 218494000763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494000764 flavoprotein, HI0933 family; Region: TIGR00275 218494000765 HMMPfam hit to PF03486, HI0933-like protein, score 1.8e-203 218494000766 1 probable transmembrane helix predicted for SSU0175 by TMHMM2.0 at aa 7-26 218494000767 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 218494000768 HMMPfam hit to PF00232, Glycoside hydrolase, family 1, score 6.9e-113 218494000769 Predicted helix-turn-helix motif with score 1683.000, SD 4.92 at aa 29-50, sequence KTVSELAEILGVSRQAMNNRVK 218494000770 HMMPfam hit to PF04394, Protein of unknown function DUF536, score 2.1e-11 218494000771 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 218494000772 PRD domain; Region: PRD; cl15445 218494000773 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 218494000774 P-loop; other site 218494000775 active site 218494000776 phosphorylation site [posttranslational modification] 218494000777 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218494000778 active site 218494000779 phosphorylation site [posttranslational modification] 218494000780 HMMPfam hit to PF00874, PRD, score 4.8e-15 218494000781 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 4.6e-28 218494000782 PS00372 PTS EIIA domains phosphorylation site signature 2. 218494000783 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 218494000784 P-loop; other site 218494000785 active site 218494000786 phosphorylation site [posttranslational modification] 218494000787 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 1.3e-24 218494000788 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 218494000789 HMMPfam hit to PF04215, sugar-specific permease, SgaT/UlaA, score 1.6e-120 218494000790 11 probable transmembrane helices predicted for SSU0180 by TMHMM2.0 at aa 5-27, 39-61, 91-110, 117-139, 143-165, 222-244, 259-281, 313-335, 339-361, 368-390 and 419-441 218494000791 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 218494000792 TPP-binding site [chemical binding]; other site 218494000793 dimer interface [polypeptide binding]; other site 218494000794 HMMPfam hit to PF00456, Transketolase, N-terminal, score 1.4e-37 218494000795 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 218494000796 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 218494000797 PYR/PP interface [polypeptide binding]; other site 218494000798 dimer interface [polypeptide binding]; other site 218494000799 TPP binding site [chemical binding]; other site 218494000800 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 218494000801 HMMPfam hit to PF02779, Transketolase, central region, score 3.5e-17 218494000802 HMMPfam hit to PF02780, Transketolase, C-terminal, score 5.9e-21 218494000803 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 218494000804 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 218494000805 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 218494000806 putative active site [active] 218494000807 catalytic site [active] 218494000808 putative metal binding site [ion binding]; other site 218494000809 7 probable transmembrane helices predicted for SSU0183 by TMHMM2.0 at aa 19-41, 61-83, 128-147, 167-186, 222-244, 259-281 and 307-329 218494000810 HMMPfam hit to PF03009, Glycerophosphoryl diester phosphodiesterase, score 5.4e-15 218494000811 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 218494000812 HMMPfam hit to PF02575, hypothetical protein CHP00103, score 4.9e-33 218494000813 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 218494000814 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 218494000815 dimer interface [polypeptide binding]; other site 218494000816 active site 218494000817 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 218494000818 putative active site [active] 218494000819 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 0.0063 218494000820 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 0.0065 218494000821 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 218494000822 G5 domain; Region: G5; pfam07501 218494000823 HMMPfam hit to PF04650, YSIRK Gram-positive signal peptide, score 7.3e-11 218494000824 2 probable transmembrane helices predicted for SSU0186 by TMHMM2.0 at aa 17-39 and 534-553 218494000825 HMMPfam hit to PF07501, G5, score 1.6e-14 218494000826 PS00017 ATP/GTP-binding site motif A (P-loop). 218494000827 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 0.00033 218494000828 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494000829 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 218494000830 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 218494000831 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 218494000832 HMMPfam hit to PF08530, Peptidase S15/CocE/NonD, C-terminal, score 1.7e-85 218494000833 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. 218494000834 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218494000835 HMMPfam hit to PF02129, Peptidase S15, score 2.3e-130 218494000836 HMMPfam hit to PF09168, X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal, score 7.7e-82 218494000837 CDS contains a frameshift after codon 24. Frameshift occurs at a poly T heptamer. Similar to Streptococcus pneumoniae hypothetical protein sp1448 UniProt:Q97PZ0 (EMBL:AE007441) (311 aa) fasta scores: E()=3.2e-69, 60.526% id in 304 aa 218494000838 HMMPfam hit to PF00144, Beta-lactamase, score 1.2e-27 218494000839 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 218494000840 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 218494000841 HMMPfam hit to PF01228, Formate C-acetyltransferase glycine radical, score 6.7e-41 218494000842 PS00850 Glycine radical signature. 218494000843 HMMPfam hit to PF02901, Pyruvate formate-lyase, PFL, score 7.5e-297 218494000844 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 218494000845 active site 218494000846 DNA polymerase IV; Validated; Region: PRK02406 218494000847 DNA binding site [nucleotide binding] 218494000848 HMMPfam hit to PF00817, UMUC-like DNA-repair protein, score 1e-103 218494000849 Predicted transcriptional regulator [Transcription]; Region: COG1959 218494000850 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494000851 HMMPfam hit to PF02082, Transcriptional regulator, Rrf2, score 4.4e-42 218494000852 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 218494000853 NAD binding site [chemical binding]; other site 218494000854 substrate binding site [chemical binding]; other site 218494000855 putative active site [active] 218494000856 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 218494000857 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 218494000858 putative substrate binding site [chemical binding]; other site 218494000859 putative ATP binding site [chemical binding]; other site 218494000860 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 8e-11 218494000861 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 218494000862 endonuclease III; Region: ENDO3c; smart00478 218494000863 minor groove reading motif; other site 218494000864 helix-hairpin-helix signature motif; other site 218494000865 substrate binding pocket [chemical binding]; other site 218494000866 active site 218494000867 HMMPfam hit to PF00730, HhH-GPD, score 1.8e-09 218494000868 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 3.2e-05 218494000869 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 218494000870 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 218494000871 HMMPfam hit to PF00480, ROK, score 8.3e-09 218494000872 Predicted helix-turn-helix motif with score 1405.000, SD 3.97 at aa 25-46, sequence SSRTRISKSLKITPATITNMIS 218494000873 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 218494000874 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 218494000875 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1.2e-86 218494000876 10 probable transmembrane helices predicted for SSU0199 by TMHMM2.0 at aa 31-53, 73-95, 107-129, 149-171, 191-213, 233-255, 299-320, 340-362, 369-391 and 406-427 218494000877 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494000878 1 probable transmembrane helix predicted for SSU0201 by TMHMM2.0 at aa 1214-1233 218494000879 1 probable transmembrane helix predicted for SSU0202 by TMHMM2.0 at aa 5-27 218494000880 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 218494000881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494000882 dimer interface [polypeptide binding]; other site 218494000883 conserved gate region; other site 218494000884 putative PBP binding loops; other site 218494000885 ABC-ATPase subunit interface; other site 218494000886 6 probable transmembrane helices predicted for SSU0203 by TMHMM2.0 at aa 12-29, 68-90, 102-124, 128-147, 176-198 and 222-244 218494000887 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 6.2e-29 218494000888 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 218494000889 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 218494000890 Walker A/P-loop; other site 218494000891 ATP binding site [chemical binding]; other site 218494000892 Q-loop/lid; other site 218494000893 ABC transporter signature motif; other site 218494000894 Walker B; other site 218494000895 D-loop; other site 218494000896 H-loop/switch region; other site 218494000897 HMMPfam hit to PF00005, ABC transporter related, score 5.5e-56 218494000898 PS00017 ATP/GTP-binding site motif A (P-loop). 218494000899 PS00017 ATP/GTP-binding site motif A (P-loop). 218494000900 PS00211 ABC transporters family signature. 218494000901 NMT1/THI5 like; Region: NMT1; pfam09084 218494000902 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218494000903 substrate binding pocket [chemical binding]; other site 218494000904 membrane-bound complex binding site; other site 218494000905 hinge residues; other site 218494000906 1 probable transmembrane helix predicted for SSU0205 by TMHMM2.0 at aa 9-31 218494000907 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494000908 HMMPfam hit to PF09084, NMT1/THI5 like, score 3.7e-18 218494000909 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 218494000910 active site 218494000911 trimer interface [polypeptide binding]; other site 218494000912 allosteric site; other site 218494000913 active site lid [active] 218494000914 hexamer (dimer of trimers) interface [polypeptide binding]; other site 218494000915 HMMPfam hit to PF01182, Glucosamine/galactosamine-6-phosphate isomerase, score 1.1e-09 218494000916 PS01161 Glucosamine/galactosamine-6-phosphate isomerases signature. 218494000917 HMMPfam hit to PF00403, Heavy metal transport/detoxification protein, score 0.0022 218494000918 PS01047 Heavy-metal-associated domain. 218494000919 2 probable transmembrane helices predicted for SSU0208 by TMHMM2.0 at aa 15-37 and 57-79 218494000920 HMMPfam hit to PF00122, E1-E2 ATPase-associated region, score 2.1e-43 218494000921 HMMPfam hit to PF00122, E1-E2 ATPase-associated region, score 1.4e-20 218494000922 1 probable transmembrane helix predicted for SSU0209 by TMHMM2.0 at aa 36-58 218494000923 HMMPfam hit to PF00122, E1-E2 ATPase-associated region, score 7.2e-16 218494000924 1 probable transmembrane helix predicted for SSU0210 by TMHMM2.0 at aa 7-29 218494000925 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 4.9e-27 218494000926 PS00154 E1-E2 ATPases phosphorylation site. 218494000927 HMMPfam hit to PF08534, Redoxin, score 0.002 218494000928 Probable gene remnant. Similar to the C-terminal region of Streptococcus parasanguis Tpx probable thiol peroxidase UniProt:P31307 (EMBL:SSSTRA) (163 aa) fasta scores: E()=8.6e-16, 72.881% id in 59 aa 218494000929 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 218494000930 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 218494000931 DNA binding site [nucleotide binding] 218494000932 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494000933 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494000934 PS00017 ATP/GTP-binding site motif A (P-loop). 218494000935 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 218494000936 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 218494000937 Catalytic site [active] 218494000938 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 218494000939 HMMPfam hit to PF00717, Peptidase S24, S26A and S26B, C-terminal, score 3.1e-19 218494000940 PS00760 Signal peptidases I lysine active site. 218494000941 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218494000942 PS00501 Signal peptidases I serine active site. 218494000943 1 probable transmembrane helix predicted for SSU0212 by TMHMM2.0 at aa 12-31 218494000944 ribonuclease HIII; Provisional; Region: PRK00996 218494000945 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 218494000946 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 218494000947 RNA/DNA hybrid binding site [nucleotide binding]; other site 218494000948 active site 218494000949 HMMPfam hit to PF01351, Ribonuclease HII/HIII, score 4.6e-64 218494000950 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 218494000951 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494000952 NAD(P) binding pocket [chemical binding]; other site 218494000953 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 218494000954 HMMPfam hit to PF01408, Oxidoreductase, N-terminal, score 3.5e-25 218494000955 HMMPfam hit to PF02894, Oxidoreductase, C-terminal, score 0.011 218494000956 1 probable transmembrane helix predicted for SSU0214 by TMHMM2.0 at aa 171-193 218494000957 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 218494000958 putative peptidoglycan binding site; other site 218494000959 1 probable transmembrane helix predicted for SSU0215 by TMHMM2.0 at aa 28-50 218494000960 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 3.6e-11 218494000961 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 218494000962 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 218494000963 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 1.8e-107 218494000964 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 218494000965 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218494000966 active site turn [active] 218494000967 phosphorylation site [posttranslational modification] 218494000968 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 218494000969 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 218494000970 HPr interaction site; other site 218494000971 glycerol kinase (GK) interaction site [polypeptide binding]; other site 218494000972 active site 218494000973 phosphorylation site [posttranslational modification] 218494000974 HMMPfam hit to PF00358, Phosphotransferase system, sugar-specific permease EIIA 1 domain, score 1.9e-61 218494000975 PS00371 PTS EIIA domains phosphorylation site signature 1. 218494000976 10 probable transmembrane helices predicted for SSU0217 by TMHMM2.0 at aa 107-129, 176-198, 205-227, 249-271, 284-306, 326-348, 361-383, 393-415, 420-442 and 462-484 218494000977 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 3.2e-38 218494000978 HMMPfam hit to PF00367, Phosphotransferase system, EIIB, score 3.1e-16 218494000979 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 218494000980 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218494000981 DNA-binding site [nucleotide binding]; DNA binding site 218494000982 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 218494000983 UTRA domain; Region: UTRA; cl01230 218494000984 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 6.9e-22 218494000985 PS00043 Bacterial regulatory proteins, gntR family signature. 218494000986 Predicted helix-turn-helix motif with score 1371.000, SD 3.86 at aa 27-48, sequence PTEQQLQEIYGVSRDTVRKALA 218494000987 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 6.8e-30 218494000988 Colicin V production protein; Region: Colicin_V; cl00567 218494000989 HMMPfam hit to PF02674, Colicin V production protein, score 9.3e-36 218494000990 4 probable transmembrane helices predicted for SSU0220 by TMHMM2.0 at aa 21-43, 78-97, 118-140 and 155-177 218494000991 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 218494000992 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 218494000993 Walker A/P-loop; other site 218494000994 ATP binding site [chemical binding]; other site 218494000995 Q-loop/lid; other site 218494000996 ABC transporter signature motif; other site 218494000997 Walker B; other site 218494000998 D-loop; other site 218494000999 H-loop/switch region; other site 218494001000 Smr domain; Region: Smr; cl02619 218494001001 HMMPfam hit to PF00488, DNA mismatch repair protein MutS, C-terminal, score 5e-16 218494001002 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001003 HMMPfam hit to PF01713, Smr protein/MutS2 C-terminal, score 2.9e-33 218494001004 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218494001005 Coenzyme A binding pocket [chemical binding]; other site 218494001006 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 218494001007 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.1e-19 218494001008 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 218494001009 catalytic residues [active] 218494001010 HMMPfam hit to PF00085, Thioredoxin domain, score 2.5e-36 218494001011 PS00194 Thioredoxin family active site. 218494001012 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 218494001013 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 218494001014 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 218494001015 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 3.6e-32 218494001016 PS00455 AMP-binding domain signature. 218494001017 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 218494001018 SelR domain; Region: SelR; cl00369 218494001019 HMMPfam hit to PF01625, Methionine sulphoxide reductase A, score 7.1e-82 218494001020 HMMPfam hit to PF01641, Methionine sulphoxide reductase B, score 6.1e-85 218494001021 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218494001022 non-specific DNA binding site [nucleotide binding]; other site 218494001023 salt bridge; other site 218494001024 sequence-specific DNA binding site [nucleotide binding]; other site 218494001025 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 9e-11 218494001026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 218494001027 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 218494001028 8 probable transmembrane helices predicted for SSU0227 by TMHMM2.0 at aa 7-29, 156-178, 206-228, 238-260, 273-295, 557-579, 599-621 and 625-644 218494001029 HMMPfam hit to PF07242, Bacteriocin-associated integral membrane protein, score 1.1e-25 218494001030 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 218494001031 FtsX-like permease family; Region: FtsX; pfam02687 218494001032 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 218494001033 7 probable transmembrane helices predicted for SSU0228 by TMHMM2.0 at aa 5-22, 146-168, 206-225, 238-260, 275-297, 557-579 and 620-642 218494001034 HMMPfam hit to PF07242, Bacteriocin-associated integral membrane protein, score 5.4e-25 218494001035 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 218494001036 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 218494001037 Walker A/P-loop; other site 218494001038 ATP binding site [chemical binding]; other site 218494001039 Q-loop/lid; other site 218494001040 ABC transporter signature motif; other site 218494001041 Walker B; other site 218494001042 D-loop; other site 218494001043 H-loop/switch region; other site 218494001044 HMMPfam hit to PF00005, ABC transporter related, score 1.6e-57 218494001045 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001046 PS00211 ABC transporters family signature. 218494001047 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 218494001048 11 probable transmembrane helices predicted for SSU0230 by TMHMM2.0 at aa 13-35, 60-82, 92-114, 144-166, 176-198, 210-227, 237-259, 298-320, 349-371, 384-401 and 411-433 218494001049 HMMPfam hit to PF01235, Sodium:alanine symporter, score 8.6e-180 218494001050 PS00873 Sodium:alanine symporter family signature. 218494001051 Mechanosensitive ion channel; Region: MS_channel; pfam00924 218494001052 3 probable transmembrane helices predicted for SSU0231 by TMHMM2.0 at aa 15-37, 73-95 and 105-127 218494001053 HMMPfam hit to PF00924, MscS Mechanosensitive ion channel, score 1.9e-47 218494001054 Telomeric repeat-binding factor 2; Region: TRF2; pfam11611 218494001055 1 probable transmembrane helix predicted for SSU0232 by TMHMM2.0 at aa 26-48 218494001056 glutamate dehydrogenase; Provisional; Region: PRK09414 218494001057 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 218494001058 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 218494001059 NAD(P) binding site [chemical binding]; other site 218494001060 HMMPfam hit to PF00208, Glu/Leu/Phe/Val dehydrogenase, C-terminal, score 8.6e-137 218494001061 HMMPfam hit to PF02812, Glu/Leu/Phe/Val dehydrogenase, dimerisation region, score 1.3e-83 218494001062 PS00074 Glu / Leu / Phe / Val dehydrogenases active site. 218494001063 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 218494001064 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 218494001065 active site 218494001066 FMN binding site [chemical binding]; other site 218494001067 substrate binding site [chemical binding]; other site 218494001068 catalytic residues [active] 218494001069 homodimer interface [polypeptide binding]; other site 218494001070 HMMPfam hit to PF01180, Dihydroorotate dehydrogenase, core, score 1.2e-110 218494001071 PS00911 Dihydroorotate dehydrogenase signature 1. 218494001072 PS00912 Dihydroorotate dehydrogenase signature 2. 218494001073 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 218494001074 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 218494001075 putative active site [active] 218494001076 putative metal binding site [ion binding]; other site 218494001077 1 probable transmembrane helix predicted for SSU0236 by TMHMM2.0 at aa 21-43 218494001078 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218494001079 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 218494001080 active site 218494001081 motif I; other site 218494001082 motif II; other site 218494001083 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 218494001084 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 5.6e-60 218494001085 PS01229 Hypothetical cof family signature 2. 218494001086 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 218494001087 Protein of unknown function (DUF990); Region: DUF990; cl01496 218494001088 HMMPfam hit to PF06182, Protein of unknown function DUF990, score 2.2e-43 218494001089 6 probable transmembrane helices predicted for SSU0238 by TMHMM2.0 at aa 26-48, 58-80, 141-163, 168-187, 194-216 and 226-248 218494001090 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 218494001091 Protein of unknown function (DUF990); Region: DUF990; cl01496 218494001092 HMMPfam hit to PF06182, Protein of unknown function DUF990, score 2.2e-06 218494001093 6 probable transmembrane helices predicted for SSU0239 by TMHMM2.0 at aa 20-39, 54-76, 108-130, 145-167, 174-196 and 226-248 218494001094 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 218494001095 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494001096 Walker A/P-loop; other site 218494001097 ATP binding site [chemical binding]; other site 218494001098 Q-loop/lid; other site 218494001099 ABC transporter signature motif; other site 218494001100 Walker B; other site 218494001101 D-loop; other site 218494001102 H-loop/switch region; other site 218494001103 HMMPfam hit to PF00005, ABC transporter related, score 2.9e-38 218494001104 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001105 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 218494001106 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494001107 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 3.2e-09 218494001108 Predicted helix-turn-helix motif with score 1431.000, SD 4.06 at aa 30-51, sequence ITTTHLAQTAGISRSSFYTHYK 218494001109 Predicted membrane protein [Function unknown]; Region: COG1511 218494001110 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 218494001111 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 218494001112 ABC-2 type transporter; Region: ABC2_membrane; cl11417 218494001113 6 probable transmembrane helices predicted for SSU0242 by TMHMM2.0 at aa 13-35, 640-662, 682-704, 708-730, 737-759 and 796-815 218494001114 HMMPfam hit to PF01061, ABC-2 type transporter, score 0.0024 218494001115 1 probable transmembrane helix predicted for SSU0243 by TMHMM2.0 at aa 7-29 218494001116 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 218494001117 5 probable transmembrane helices predicted for SSU0244 by TMHMM2.0 at aa 81-103, 108-125, 138-160, 170-192 and 204-226 218494001118 HMMPfam hit to PF08006, Protein of unknown function DUF1700, score 5.2e-05 218494001119 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494001120 HMMPfam hit to PF03551, Transcriptional regulator PadR-like, score 1e-18 218494001121 LrgA family; Region: LrgA; cl00608 218494001122 HMMPfam hit to PF03788, LrgA, score 5.4e-41 218494001123 3 probable transmembrane helices predicted for SSU0246 by TMHMM2.0 at aa 20-42, 55-74 and 84-106 218494001124 LrgB-like family; Region: LrgB; cl00596 218494001125 8 probable transmembrane helices predicted for SSU0247 by TMHMM2.0 at aa 10-32, 39-61, 65-87, 100-122, 126-145, 152-174, 184-206 and 213-235 218494001126 HMMPfam hit to PF04172, LrgB-like protein, score 3.4e-106 218494001127 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 218494001128 HMMPfam hit to PF01226, Formate/nitrite transporter, score 1.1e-16 218494001129 6 probable transmembrane helices predicted for SSU0248 by TMHMM2.0 at aa 29-51, 71-93, 114-136, 156-178, 185-207 and 235-257 218494001130 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 218494001131 amphipathic channel; other site 218494001132 Asn-Pro-Ala signature motifs; other site 218494001133 HMMPfam hit to PF00230, Major intrinsic protein, score 3.2e-23 218494001134 6 probable transmembrane helices predicted for SSU0249 by TMHMM2.0 at aa 5-27, 42-64, 71-93, 152-174, 195-217 and 257-279 218494001135 PS00221 MIP family signature. 218494001136 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 218494001137 HMMPfam hit to PF05872, Protein of unknown function DUF853, NPT hydrolase , score 6e-248 218494001138 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001139 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 218494001140 putative active site [active] 218494001141 putative CoA binding site [chemical binding]; other site 218494001142 nudix motif; other site 218494001143 metal binding site [ion binding]; metal-binding site 218494001144 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 1.4e-15 218494001145 PS00893 mutT domain signature. 218494001146 Predicted membrane protein [Function unknown]; Region: COG5373 218494001147 MAEBL; Provisional; Region: PTZ00121 218494001148 2 probable transmembrane helices predicted for SSU0253 by TMHMM2.0 at aa 7-26 and 740-759 218494001149 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 1.3e-06 218494001150 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494001151 CDS contains a nonsense mutation (opal) after codon 239. C-terminal region is simlar to Streptococcus pneumoniae surface protein PspC UniProt:Q8RQ77 (EMBL:AF276620) (612 aa) fasta scores: E()=6.3e-25, 35.897% id in 429 aa 218494001152 1 probable transmembrane helix predicted for SSU0254 by TMHMM2.0 at aa 7-29 218494001153 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 0.00041 218494001154 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494001155 Probable gene remnant. CDS contains a nonsense mutation (opal) after codon 10. Similar to an internal region of Streptococcus pneumoniae (strain ATCC BAA-255/R6) IS861-truncation degenerate transposase (Orf1) UniProt:Q8DQ22 (EMBL:AE008462) (65 aa) fasta scores: E()=0.58, 40.000% id in 30 aa 218494001156 Probable gene remnant. Similar to the C-terminal region of Streptococcus agalactiae (serotype V) phage integrase family site-specific recombinase UniProt:Q8DWV1 (EMBL:AE014287) (494 aa) fasta scores: E()=0.00046, 55.814% id in 43 aa 218494001157 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 218494001158 HMMPfam hit to PF00471, Ribosomal protein L33, score 5.7e-18 218494001159 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 218494001160 HMMPfam hit to PF01783, Ribosomal protein L32p, score 4.8e-22 218494001161 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 218494001162 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 218494001163 dimer interface [polypeptide binding]; other site 218494001164 motif 1; other site 218494001165 active site 218494001166 motif 2; other site 218494001167 motif 3; other site 218494001168 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 218494001169 anticodon binding site; other site 218494001170 HMMPfam hit to PF00587, Aminoacyl-tRNA synthetase, class II (G, H, P and S), score 9.9e-58 218494001171 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218494001172 HMMPfam hit to PF03129, Anticodon-binding, score 3.4e-20 218494001173 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 218494001174 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 218494001175 NAD binding site [chemical binding]; other site 218494001176 substrate binding site [chemical binding]; other site 218494001177 catalytic Zn binding site [ion binding]; other site 218494001178 tetramer interface [polypeptide binding]; other site 218494001179 structural Zn binding site [ion binding]; other site 218494001180 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 3.7e-37 218494001181 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 3.2e-47 218494001182 PS00059 Zinc-containing alcohol dehydrogenases signature. 218494001183 PS00190 Cytochrome c family heme-binding site signature. 218494001184 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 218494001185 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 218494001186 putative catalytic cysteine [active] 218494001187 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 218494001188 putative active site [active] 218494001189 metal binding site [ion binding]; metal-binding site 218494001190 Predicted helix-turn-helix motif with score 1186.000, SD 3.23 at aa 393-414, sequence TEDAELAKEFGTIVRAIRVIWN 218494001191 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 1.9e-144 218494001192 PS00913 Iron-containing alcohol dehydrogenases signature 1. 218494001193 PS00060 Iron-containing alcohol dehydrogenases signature 2. 218494001194 Predicted helix-turn-helix motif with score 1004.000, SD 2.61 at aa 785-806, sequence EKYQDIARLLGLPCSTPEEAVA 218494001195 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 218494001196 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 218494001197 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218494001198 catalytic residue [active] 218494001199 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 9.6e-11 218494001200 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 218494001201 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 218494001202 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494001203 Walker A/P-loop; other site 218494001204 ATP binding site [chemical binding]; other site 218494001205 Q-loop/lid; other site 218494001206 ABC transporter signature motif; other site 218494001207 Walker B; other site 218494001208 D-loop; other site 218494001209 H-loop/switch region; other site 218494001210 5 probable transmembrane helices predicted for SSU0263 by TMHMM2.0 at aa 34-56, 71-90, 163-185, 254-276 and 283-305 218494001211 HMMPfam hit to PF00005, ABC transporter related, score 5.3e-33 218494001212 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001213 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 218494001214 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 218494001215 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 218494001216 Walker A/P-loop; other site 218494001217 ATP binding site [chemical binding]; other site 218494001218 Q-loop/lid; other site 218494001219 ABC transporter signature motif; other site 218494001220 Walker B; other site 218494001221 D-loop; other site 218494001222 H-loop/switch region; other site 218494001223 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 1.8e-05 218494001224 6 probable transmembrane helices predicted for SSU0264 by TMHMM2.0 at aa 28-50, 60-78, 134-156, 161-183, 250-272 and 282-304 218494001225 HMMPfam hit to PF00005, ABC transporter related, score 4.3e-47 218494001226 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001227 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 218494001228 5 probable transmembrane helices predicted for SSU0265 by TMHMM2.0 at aa 10-32, 39-61, 76-98, 111-133 and 164-186 218494001229 Cobalt transport protein; Region: CbiQ; cl00463 218494001230 3 probable transmembrane helices predicted for SSU0266 by TMHMM2.0 at aa 20-42, 55-77 and 195-217 218494001231 HMMPfam hit to PF02361, Cobalt transport protein, score 7.5e-11 218494001232 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 218494001233 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 218494001234 Walker A/P-loop; other site 218494001235 ATP binding site [chemical binding]; other site 218494001236 Q-loop/lid; other site 218494001237 ABC transporter signature motif; other site 218494001238 Walker B; other site 218494001239 D-loop; other site 218494001240 H-loop/switch region; other site 218494001241 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494001242 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 218494001243 Walker A/P-loop; other site 218494001244 ATP binding site [chemical binding]; other site 218494001245 Q-loop/lid; other site 218494001246 ABC transporter signature motif; other site 218494001247 Walker B; other site 218494001248 D-loop; other site 218494001249 H-loop/switch region; other site 218494001250 HMMPfam hit to PF00005, ABC transporter related, score 1.3e-49 218494001251 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 218494001252 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001253 PS00211 ABC transporters family signature. 218494001254 HMMPfam hit to PF00005, ABC transporter related, score 8e-35 218494001255 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001256 PS00211 ABC transporters family signature. 218494001257 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 218494001258 MatE; Region: MatE; cl10513 218494001259 MatE; Region: MatE; cl10513 218494001260 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 4.1e-31 218494001261 10 probable transmembrane helices predicted for SSU0268 by TMHMM2.0 at aa 24-46, 53-75, 95-117, 129-151, 173-195, 242-261, 266-285, 302-324, 339-361 and 383-405 218494001262 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494001263 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 1.4e-20 218494001264 mevalonate kinase; Region: mevalon_kin; TIGR00549 218494001265 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 218494001266 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 218494001267 HMMPfam hit to PF00288, GHMP kinase, score 1.8e-20 218494001268 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001269 PS00141 Eukaryotic and viral aspartyl proteases active site. 218494001270 HMMPfam hit to PF08544, GHMP kinase, C-terminal, score 1.9e-12 218494001271 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 218494001272 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 218494001273 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 218494001274 HMMPfam hit to PF00288, GHMP kinase, score 1.7e-10 218494001275 HMMPfam hit to PF08544, GHMP kinase, C-terminal, score 0.00032 218494001276 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 218494001277 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 218494001278 HMMPfam hit to PF00288, GHMP kinase, score 7.6e-10 218494001279 HMMPfam hit to PF08544, GHMP kinase, C-terminal, score 2.4e-08 218494001280 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 218494001281 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 218494001282 homotetramer interface [polypeptide binding]; other site 218494001283 FMN binding site [chemical binding]; other site 218494001284 homodimer contacts [polypeptide binding]; other site 218494001285 putative active site [active] 218494001286 putative substrate binding site [chemical binding]; other site 218494001287 HMMPfam hit to PF01645, Glutamate synthase, central-C, score 1.8e-06 218494001288 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 218494001289 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 218494001290 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 218494001291 Walker A/P-loop; other site 218494001292 ATP binding site [chemical binding]; other site 218494001293 Q-loop/lid; other site 218494001294 ABC transporter signature motif; other site 218494001295 Walker B; other site 218494001296 D-loop; other site 218494001297 H-loop/switch region; other site 218494001298 HMMPfam hit to PF00005, ABC transporter related, score 9.3e-57 218494001299 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001300 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 1.8e-32 218494001301 5 probable transmembrane helices predicted for SSU0273 by TMHMM2.0 at aa 20-42, 52-74, 136-158, 162-179 and 247-269 218494001302 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 218494001303 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 218494001304 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494001305 Walker A/P-loop; other site 218494001306 ATP binding site [chemical binding]; other site 218494001307 Q-loop/lid; other site 218494001308 ABC transporter signature motif; other site 218494001309 Walker B; other site 218494001310 D-loop; other site 218494001311 H-loop/switch region; other site 218494001312 HMMPfam hit to PF00005, ABC transporter related, score 2.1e-53 218494001313 PS00211 ABC transporters family signature. 218494001314 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001315 6 probable transmembrane helices predicted for SSU0274 by TMHMM2.0 at aa 21-43, 58-77, 130-152, 156-178, 242-264 and 279-301 218494001316 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 1.9e-39 218494001317 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 218494001318 HMMPfam hit to PF01842, Amino acid-binding ACT, score 8e-09 218494001319 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 218494001320 HMMPfam hit to PF05167, Protein of unknown function DUF711, score 7.5e-278 218494001321 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 218494001322 catalytic core [active] 218494001323 HMMPfam hit to PF00300, Phosphoglycerate mutase, score 7.3e-35 218494001324 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 218494001325 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494001326 HrcA protein C terminal domain; Region: HrcA; pfam01628 218494001327 HMMPfam hit to PF01628, Negative regulator of class I heat shock protein, score 6.2e-53 218494001328 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 218494001329 dimer interface [polypeptide binding]; other site 218494001330 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 218494001331 HMMPfam hit to PF01025, GrpE nucleotide exchange factor, score 2.8e-60 218494001332 PS01071 grpE protein signature. 218494001333 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 218494001334 HMMPfam hit to PF00012, Heat shock protein 70, score 0 218494001335 PS00297 Heat shock hsp70 proteins family signature 1. 218494001336 PS00329 Heat shock hsp70 proteins family signature 2. 218494001337 PS01036 Heat shock hsp70 proteins family signature 3. 218494001338 chaperone protein DnaJ; Provisional; Region: PRK14276 218494001339 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 218494001340 HSP70 interaction site [polypeptide binding]; other site 218494001341 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 218494001342 substrate binding site [polypeptide binding]; other site 218494001343 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 218494001344 Zn binding sites [ion binding]; other site 218494001345 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 218494001346 dimer interface [polypeptide binding]; other site 218494001347 HMMPfam hit to PF00226, Heat shock protein DnaJ, N-terminal, score 1.2e-37 218494001348 PS00636 Nt-dnaJ domain signature. 218494001349 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218494001350 HMMPfam hit to PF00684, DnaJ central region, score 8.1e-34 218494001351 PS00637 CXXCXGXG dnaJ domain signature. 218494001352 PS00190 Cytochrome c family heme-binding site signature. 218494001353 PS00190 Cytochrome c family heme-binding site signature. 218494001354 HMMPfam hit to PF01556, Chaperone DnaJ, C-terminal, score 1.2e-67 218494001355 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 218494001356 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 218494001357 amidase; Provisional; Region: PRK06529 218494001358 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 218494001359 HMMPfam hit to PF01425, Amidase signature enzyme, score 9.6e-70 218494001360 PS00571 Amidases signature. 218494001361 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218494001362 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 218494001363 substrate binding pocket [chemical binding]; other site 218494001364 membrane-bound complex binding site; other site 218494001365 hinge residues; other site 218494001366 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494001367 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 3.3e-58 218494001368 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 218494001369 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218494001370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494001371 dimer interface [polypeptide binding]; other site 218494001372 conserved gate region; other site 218494001373 putative PBP binding loops; other site 218494001374 ABC-ATPase subunit interface; other site 218494001375 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.5e-23 218494001376 3 probable transmembrane helices predicted for SSU0285 by TMHMM2.0 at aa 27-49, 70-89 and 191-213 218494001377 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494001378 Predicted helix-turn-helix motif with score 1554.000, SD 4.48 at aa 17-38, sequence MTSKDLAEQVGITEANLSILKT 218494001379 4 probable transmembrane helices predicted for SSU0287 by TMHMM2.0 at aa 20-42, 57-79, 106-128 and 143-160 218494001380 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 218494001381 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 218494001382 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 218494001383 6 probable transmembrane helices predicted for SSU0288 by TMHMM2.0 at aa 13-35, 73-95, 239-261, 271-293, 576-595 and 599-621 218494001384 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 2.9e-32 218494001385 PS01229 Hypothetical cof family signature 2. 218494001386 PS00154 E1-E2 ATPases phosphorylation site. 218494001387 HMMPfam hit to PF00122, E1-E2 ATPase-associated region, score 2.9e-65 218494001388 Predicted helix-turn-helix motif with score 1444.000, SD 4.11 at aa 108-129, sequence KSKNAIAALMNMTPPTARKIEE 218494001389 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 218494001390 metal binding site 2 [ion binding]; metal-binding site 218494001391 putative DNA binding helix; other site 218494001392 metal binding site 1 [ion binding]; metal-binding site 218494001393 dimer interface [polypeptide binding]; other site 218494001394 structural Zn2+ binding site [ion binding]; other site 218494001395 HMMPfam hit to PF01475, Ferric-uptake regulator, score 3.3e-46 218494001396 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 218494001397 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 218494001398 dimerization interface 3.5A [polypeptide binding]; other site 218494001399 active site 218494001400 HMMPfam hit to PF01416, tRNA pseudouridine synthase, score 3.8e-40 218494001401 HMMPfam hit to PF01416, tRNA pseudouridine synthase, score 1.1e-30 218494001402 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 218494001403 substrate binding site [chemical binding]; other site 218494001404 dimer interface [polypeptide binding]; other site 218494001405 ATP binding site [chemical binding]; other site 218494001406 HMMPfam hit to PF08543, Phosphomethylpyrimidine kinase type-1, score 8.8e-74 218494001407 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 218494001408 4 probable transmembrane helices predicted for SSU0292 by TMHMM2.0 at aa 9-26, 30-49, 54-76 and 96-118 218494001409 Protein of unknown function (DUF436); Region: DUF436; cl01860 218494001410 HMMPfam hit to PF04260, hypothetical protein CHP01440, score 5.8e-121 218494001411 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 218494001412 HMMPfam hit to PF07081, Protein of unknown function DUF1349, score 4e-53 218494001413 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. 218494001414 Predicted transcriptional regulator [Transcription]; Region: COG1959 218494001415 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494001416 HMMPfam hit to PF02082, Transcriptional regulator, Rrf2, score 2.1e-31 218494001417 Predicted helix-turn-helix motif with score 1320.000, SD 3.68 at aa 22-43, sequence LSSQALAESVGTNASYIRKVIA 218494001418 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 218494001419 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 218494001420 putative NAD(P) binding site [chemical binding]; other site 218494001421 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 1.6e-23 218494001422 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 6.7e-13 218494001423 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 218494001424 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 218494001425 HMMPfam hit to PF00561, Alpha/beta hydrolase fold-1, score 7e-22 218494001426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494001427 NAD(P) binding site [chemical binding]; other site 218494001428 active site 218494001429 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 8.7e-09 218494001430 PS00061 Short-chain dehydrogenases/reductases family signature. 218494001431 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 218494001432 putative active site [active] 218494001433 putative FMN binding site [chemical binding]; other site 218494001434 putative substrate binding site [chemical binding]; other site 218494001435 putative catalytic residue [active] 218494001436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494001437 HMMPfam hit to PF00724, NADH:flavin oxidoreductase/NADH oxidase, N-terminal, score 4.9e-41 218494001438 Predicted transcriptional regulator [Transcription]; Region: COG1959 218494001439 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494001440 HMMPfam hit to PF02082, Transcriptional regulator, Rrf2, score 4.5e-36 218494001441 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 218494001442 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494001443 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 2.2e-11 218494001444 Predicted helix-turn-helix motif with score 1126.000, SD 3.02 at aa 34-55, sequence ISVSELVERAGIGRVTFYRNFS 218494001445 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 218494001446 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 218494001447 1 probable transmembrane helix predicted for SSU0304 by TMHMM2.0 at aa 4-23 218494001448 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494001449 HMMPfam hit to PF07224, Chlorophyllase, score 0.00047 218494001450 PS00120 Lipases, serine active site. 218494001451 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 218494001452 1 probable transmembrane helix predicted for SSU0305 by TMHMM2.0 at aa 7-26 218494001453 HMMPfam hit to PF07859, Alpha/beta hydrolase fold-3, score 3.7e-13 218494001454 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218494001455 trigger factor; Provisional; Region: tig; PRK01490 218494001456 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 218494001457 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 218494001458 HMMPfam hit to PF05697, Bacterial trigger factor, N-terminal, score 1.6e-64 218494001459 HMMPfam hit to PF00254, Peptidyl-prolyl cis-trans isomerase, FKBP-type, score 3.6e-26 218494001460 HMMPfam hit to PF05698, Bacterial trigger factor, C-terminal, score 1.3e-66 218494001461 Predicted helix-turn-helix motif with score 1100.000, SD 2.93 at aa 382-403, sequence KEIEDLAATYNMEVAQVRSLLS 218494001462 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 218494001463 poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937 218494001464 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 218494001465 4 probable transmembrane helices predicted for SSU0307 by TMHMM2.0 at aa 165-182, 186-205, 210-232 and 252-274 218494001466 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 218494001467 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 218494001468 intersubunit interface [polypeptide binding]; other site 218494001469 HMMPfam hit to PF01297, Periplasmic solute binding protein, score 8.4e-89 218494001470 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494001471 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 218494001472 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 218494001473 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 218494001474 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 218494001475 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 218494001476 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 218494001477 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 218494001478 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 218494001479 1 probable transmembrane helix predicted for SSU0309 by TMHMM2.0 at aa 5-27 218494001480 HMMPfam hit to PF04270, Streptococcal histidine triad, score 4.9 218494001481 HMMPfam hit to PF04270, Streptococcal histidine triad, score 4.3e-31 218494001482 HMMPfam hit to PF04270, Streptococcal histidine triad, score 7.8e-05 218494001483 HMMPfam hit to PF04270, Streptococcal histidine triad, score 5.1e-05 218494001484 HMMPfam hit to PF04270, Streptococcal histidine triad, score 0.016 218494001485 HMMPfam hit to PF04270, Streptococcal histidine triad, score 0.00077 218494001486 HMMPfam hit to PF04270, Streptococcal histidine triad, score 0.00014 218494001487 HMMPfam hit to PF04270, Streptococcal histidine triad, score 3.9 218494001488 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 218494001489 HMMPfam hit to PF05066, DNA-directed RNA polymerase delta subunit, score 5e-83 218494001490 CTP synthetase; Validated; Region: pyrG; PRK05380 218494001491 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 218494001492 Catalytic site [active] 218494001493 active site 218494001494 UTP binding site [chemical binding]; other site 218494001495 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 218494001496 active site 218494001497 putative oxyanion hole; other site 218494001498 catalytic triad [active] 218494001499 HMMPfam hit to PF06418, CTP synthase, score 3.1e-215 218494001500 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 1.6e-68 218494001501 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 218494001502 hypothetical protein; Provisional; Region: PRK08185 218494001503 intersubunit interface [polypeptide binding]; other site 218494001504 active site 218494001505 zinc binding site [ion binding]; other site 218494001506 Na+ binding site [ion binding]; other site 218494001507 HMMPfam hit to PF01116, Ketose-bisphosphate aldolase, class-II, score 4.3e-115 218494001508 PS00602 Fructose-bisphosphate aldolase class-II signature 1. 218494001509 PS00806 Fructose-bisphosphate aldolase class-II signature 2. 218494001510 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 218494001511 HMMPfam hit to PF00830, Ribosomal protein L28, score 4.2e-23 218494001512 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 218494001513 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 218494001514 generic binding surface II; other site 218494001515 ssDNA binding site; other site 218494001516 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218494001517 ATP binding site [chemical binding]; other site 218494001518 putative Mg++ binding site [ion binding]; other site 218494001519 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218494001520 nucleotide binding region [chemical binding]; other site 218494001521 ATP-binding site [chemical binding]; other site 218494001522 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 5.8e-39 218494001523 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001524 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 1.9e-24 218494001525 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 218494001526 active site 218494001527 homotetramer interface [polypeptide binding]; other site 218494001528 homodimer interface [polypeptide binding]; other site 218494001529 HMMPfam hit to PF00710, Asparaginase/glutaminase, score 1.5e-133 218494001530 PS00917 Asparaginase / glutaminase active site signature 2. 218494001531 PS00144 Asparaginase / glutaminase active site signature 1. 218494001532 CDS contains a frameshift after codon 280. Similar to Streptococcus pneumoniae Cof family protein UniProt:Q97NM3 (EMBL:AE007488) (462 aa) fasta scores: E()=3.5e-89, 52.772% id in 451 aa 218494001533 PS01228 Hypothetical cof family signature 1. 218494001534 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 8.2e-82 218494001535 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 218494001536 Ligand Binding Site [chemical binding]; other site 218494001537 HMMPfam hit to PF00582, UspA, score 1.3e-23 218494001538 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 218494001539 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218494001540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218494001541 homodimer interface [polypeptide binding]; other site 218494001542 catalytic residue [active] 218494001543 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 4e-36 218494001544 transcriptional repressor CodY; Validated; Region: PRK04158 218494001545 CodY GAF-like domain; Region: CodY; pfam06018 218494001546 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494001547 HMMPfam hit to PF06018, GTP-sensing transcriptional pleiotropic repressor CodY, N-terminal, score 2.5e-105 218494001548 HMMPfam hit to PF08222, GTP-sensing helix-turn-helix, CodY, C-terminal, score 1.7e-37 218494001549 Predicted helix-turn-helix motif with score 1428.000, SD 4.05 at aa 205-226, sequence LTASVIADRIGITRSVIVNALR 218494001550 CDS contains a frameshift after codon 7. Possible alternative translational start site after codon 4. Similar to Streptococcus mutans pyrazinamidase/nicotinamidase PncA UniProt:Q8DSG2 (EMBL:AE015009) (183 aa) fasta scores: E()=3.2e-54, 78.022% id in 182 aa 218494001551 HMMPfam hit to PF00857, Isochorismatase hydrolase, score 1.2e-07 218494001552 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001553 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 218494001554 HMMPfam hit to PF01245, Ribosomal protein L19, score 1.5e-71 218494001555 PS01015 Ribosomal protein L19 signature. 218494001556 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 218494001557 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 218494001558 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 218494001559 HMMPfam hit to PF02686, Glu-tRNAGln amidotransferase, C subunit, score 1.2e-15 218494001560 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 218494001561 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 218494001562 HMMPfam hit to PF01425, Amidase signature enzyme, score 7.4e-186 218494001563 PS00571 Amidases signature. 218494001564 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 218494001565 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 218494001566 GatB domain; Region: GatB_Yqey; cl11497 218494001567 HMMPfam hit to PF02934, GatB N-terminal region, score 1e-146 218494001568 HMMPfam hit to PF01162, GatB, central region, score 4.5e-30 218494001569 HMMPfam hit to PF02637, GatB/Yqey, score 3.7e-61 218494001570 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 218494001571 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 1.3e-07 218494001572 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 218494001573 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218494001574 DNA binding site [nucleotide binding] 218494001575 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 218494001576 putative dimerization interface [polypeptide binding]; other site 218494001577 putative ligand binding site [chemical binding]; other site 218494001578 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 0.0018 218494001579 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 3.9e-08 218494001580 Predicted helix-turn-helix motif with score 2067.000, SD 6.23 at aa 2-23, sequence VTIKDIAKQAHLSSATVSRVLK 218494001581 galactokinase; Provisional; Region: PRK05322 218494001582 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 218494001583 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 218494001584 PS00106 Galactokinase signature. 218494001585 HMMPfam hit to PF00288, GHMP kinase, score 8.4e-19 218494001586 PS00627 GHMP kinases ATP-binding domain. 218494001587 PS00012 Phosphopantetheine attachment site. 218494001588 HMMPfam hit to PF08544, GHMP kinase, C-terminal, score 8.4e-15 218494001589 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 218494001590 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 218494001591 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 218494001592 HMMPfam hit to PF01087, Galactose-1-phosphate uridyl transferase, N-terminal, score 1.2e-79 218494001593 HMMPfam hit to PF02744, Galactose-1-phosphate uridyl transferase, C-terminal, score 1.5e-85 218494001594 EamA-like transporter family; Region: EamA; cl01037 218494001595 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 218494001596 EamA-like transporter family; Region: EamA; cl01037 218494001597 10 probable transmembrane helices predicted for SSU0331 by TMHMM2.0 at aa 7-29, 39-58, 71-93, 97-119, 126-144, 154-176, 183-205, 215-237, 244-266 and 271-291 218494001598 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 3.8e-16 218494001599 HMMPfam hit to PF00892, Protein of unknown function DUF6, transmembrane, score 7.4e-21 218494001600 CutC family; Region: CutC; cl01218 218494001601 HMMPfam hit to PF03932, CutC, score 2.1e-72 218494001602 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218494001603 active site 218494001604 motif I; other site 218494001605 motif II; other site 218494001606 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 4.3e-12 218494001607 GTPase YqeH; Provisional; Region: PRK13796 218494001608 YqeH. YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically...; Region: YqeH; cd01855 218494001609 GTP/Mg2+ binding site [chemical binding]; other site 218494001610 G4 box; other site 218494001611 G5 box; other site 218494001612 G1 box; other site 218494001613 Switch I region; other site 218494001614 G2 box; other site 218494001615 G3 box; other site 218494001616 Switch II region; other site 218494001617 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 6.5e-12 218494001618 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001619 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 218494001620 HMMPfam hit to PF01985, CRS1/YhbY, score 2.6e-33 218494001621 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 218494001622 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 218494001623 active site 218494001624 (T/H)XGH motif; other site 218494001625 HMMPfam hit to PF01467, Cytidylyltransferase, score 5.5e-62 218494001626 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 218494001627 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 218494001628 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 1.5e-21 218494001629 CDS lacks a translational start codon, and is disrupted by a 277bp DNA region. Similar to Bacillus thuringiensis serovar konkukian str. 97-27 acetyltransferase UniProt:Q5LK91 (EMBL:CP000047) (148 aa) fasta scores: E()=6.8e-14, 36.429% id in 140 aa 218494001630 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 0.0015 218494001631 CDS contains a nonsense mutation (ochre) after codon 29, and a frameshift after codon 57. Similar to Streptococcus agalactiae (serotype III) hypothetical protein GBS1704 UniProt:Q8E3Q2 (EMBL:SAG766852) (173 aa) fasta scores: E()=1.7e-21, 42.262% id in 168 aa 218494001632 HMMPfam hit to PF00857, Isochorismatase hydrolase, score 2.2e-09 218494001633 Domain of unknown function DUF143; Region: DUF143; cl00519 218494001634 HMMPfam hit to PF02410, Iojap-related protein, score 4.5e-45 218494001635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218494001636 S-adenosylmethionine binding site [chemical binding]; other site 218494001637 HMMPfam hit to PF08241, Methyltransferase type 11, score 4.8e-16 218494001638 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001639 2 probable transmembrane helices predicted for SSU0344 by TMHMM2.0 at aa 159-178 and 199-221 218494001640 hypothetical protein; Provisional; Region: PRK13670 218494001641 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 218494001642 HMMPfam hit to PF05636, Protein of unknown function DUF795, score 1.8e-181 218494001643 PS00133 Zinc carboxypeptidases, zinc-binding region 2 signature. 218494001644 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 218494001645 DNA binding residues [nucleotide binding] 218494001646 dimer interface [polypeptide binding]; other site 218494001647 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 218494001648 HMMPfam hit to PF00376, Bacterial regulatory protein, MerR, score 2.4e-11 218494001649 HMMPfam hit to PF07739, TipAS antibiotic-recognition, score 1.4e-50 218494001650 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494001651 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001652 Domain of unknown function DUF87; Region: DUF87; pfam01935 218494001653 AAA-like domain; Region: AAA_10; pfam12846 218494001654 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001655 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 218494001656 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 218494001657 active site 218494001658 catalytic residues [active] 218494001659 metal binding site [ion binding]; metal-binding site 218494001660 HMMPfam hit to PF01327, Formylmethionine deformylase, score 2.8e-12 218494001661 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218494001662 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 218494001663 Walker A motif; other site 218494001664 ATP binding site [chemical binding]; other site 218494001665 Walker B motif; other site 218494001666 arginine finger; other site 218494001667 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218494001668 Walker A motif; other site 218494001669 ATP binding site [chemical binding]; other site 218494001670 Walker B motif; other site 218494001671 arginine finger; other site 218494001672 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 218494001673 HMMPfam hit to PF00004, AAA ATPase, core, score 4.7e-18 218494001674 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001675 HMMPfam hit to PF07724, ATPase AAA-2, score 6.1e-76 218494001676 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001677 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 218494001678 HMMPfam hit to PF02446, Glycoside hydrolase, family 77, score 5.6e-200 218494001679 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 218494001680 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 218494001681 HMMPfam hit to PF00343, Glycosyl transferase, family 35, score 2.3e-190 218494001682 PS00102 Phosphorylase pyridoxal-phosphate attachment site. 218494001683 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 218494001684 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218494001685 DNA-binding site [nucleotide binding]; DNA binding site 218494001686 UTRA domain; Region: UTRA; cl01230 218494001687 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 2.8e-30 218494001688 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 5.4e-17 218494001689 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 218494001690 putative catalytic site [active] 218494001691 putative metal binding site [ion binding]; other site 218494001692 putative phosphate binding site [ion binding]; other site 218494001693 HMMPfam hit to PF03372, Endonuclease/exonuclease/phosphatase, score 1.9e-11 218494001694 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 218494001695 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 218494001696 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218494001697 active site turn [active] 218494001698 phosphorylation site [posttranslational modification] 218494001699 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 218494001700 HPr interaction site; other site 218494001701 glycerol kinase (GK) interaction site [polypeptide binding]; other site 218494001702 active site 218494001703 phosphorylation site [posttranslational modification] 218494001704 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1.7e-37 218494001705 9 probable transmembrane helices predicted for SSU0357 by TMHMM2.0 at aa 16-38, 53-75, 82-104, 114-136, 143-165, 180-202, 338-355, 360-382 and 415-437 218494001706 HMMPfam hit to PF00367, Phosphotransferase system, EIIB, score 5.2e-16 218494001707 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 218494001708 HMMPfam hit to PF00358, Phosphotransferase system, sugar-specific permease EIIA 1 domain, score 5.3e-57 218494001709 PS00371 PTS EIIA domains phosphorylation site signature 1. 218494001710 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 218494001711 2 probable transmembrane helices predicted for SSU0358 by TMHMM2.0 at aa 116-135 and 172-194 218494001712 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494001713 HMMPfam hit to PF03551, Transcriptional regulator PadR-like, score 3e-08 218494001714 Domain of unknown function DUF28; Region: DUF28; cl00361 218494001715 HMMPfam hit to PF01709, Protein of unknown function DUF28, score 7.7e-130 218494001716 Uncharacterized conserved protein [Function unknown]; Region: COG1912 218494001717 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 218494001718 HMMPfam hit to PF01887, Protein of unknown function DUF62, score 5.8e-76 218494001719 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 218494001720 HMMPfam hit to PF07155, Protein of unknown function DUF1393, score 4.2e-120 218494001721 5 probable transmembrane helices predicted for SSU0362 by TMHMM2.0 at aa 10-32, 45-64, 74-91, 108-130 and 145-167 218494001722 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 218494001723 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 218494001724 active site residue [active] 218494001725 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 218494001726 HMMPfam hit to PF00581, Rhodanese-like, score 6.4e-15 218494001727 CDS contains a nonsense mutation (opal) after codon 10, and lack a translational start codon. Similar to Staphylococcus aureus (strain Mu50/ATCC 700699) hypothetical protein UniProt:Q99R63 (EMBL:BA000017) (125 aa) fasta scores: E()=3.4e-06, 34.513% id in 113 aa 218494001728 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 218494001729 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 218494001730 Walker A/P-loop; other site 218494001731 ATP binding site [chemical binding]; other site 218494001732 Q-loop/lid; other site 218494001733 ABC transporter signature motif; other site 218494001734 Walker B; other site 218494001735 D-loop; other site 218494001736 H-loop/switch region; other site 218494001737 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 218494001738 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 218494001739 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 218494001740 Walker A/P-loop; other site 218494001741 ATP binding site [chemical binding]; other site 218494001742 Q-loop/lid; other site 218494001743 ABC transporter signature motif; other site 218494001744 Walker B; other site 218494001745 D-loop; other site 218494001746 H-loop/switch region; other site 218494001747 HMMPfam hit to PF00005, ABC transporter related, score 2.4e-33 218494001748 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001749 PS00211 ABC transporters family signature. 218494001750 HMMPfam hit to PF00005, ABC transporter related, score 3.5e-54 218494001751 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001752 PS00211 ABC transporters family signature. 218494001753 PS00963 Ribosomal protein S2 signature 2. 218494001754 Cobalt transport protein; Region: CbiQ; cl00463 218494001755 HMMPfam hit to PF02361, Cobalt transport protein, score 2.9e-21 218494001756 4 probable transmembrane helices predicted for SSU0367 by TMHMM2.0 at aa 15-37, 65-87, 115-137 and 248-267 218494001757 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218494001758 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 218494001759 DNA-binding site [nucleotide binding]; DNA binding site 218494001760 RNA-binding motif; other site 218494001761 HMMPfam hit to PF00313, Cold-shock protein, DNA-binding, score 1.5e-40 218494001762 PS00352 'Cold-shock' DNA-binding domain signature. 218494001763 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 218494001764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 218494001765 HMMPfam hit to PF02527, Glucose inhibited division protein, score 5.5e-56 218494001766 Transglycosylase; Region: Transgly; cl07896 218494001767 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 218494001768 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 218494001769 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 8.5e-28 218494001770 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001771 HMMPfam hit to PF00912, Glycosyl transferase, family 51, score 1.2e-80 218494001772 1 probable transmembrane helix predicted for SSU0370 by TMHMM2.0 at aa 13-35 218494001773 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494001774 Recombination protein U; Region: RecU; cl01314 218494001775 HMMPfam hit to PF03838, Recombination protein U, score 7.4e-112 218494001776 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 218494001777 HMMPfam hit to PF06908, Protein of unknown function DUF1273, score 6.3e-99 218494001778 cell division protein GpsB; Provisional; Region: PRK14127 218494001779 DivIVA domain; Region: DivI1A_domain; TIGR03544 218494001780 HMMPfam hit to PF05103, DivIVA, score 2.2e-16 218494001781 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 218494001782 THUMP domain; Region: THUMP; cl12076 218494001783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 218494001784 HMMPfam hit to PF01170, RNA methylase, score 3.1e-65 218494001785 PS00092 N-6 Adenine-specific DNA methylases signature. 218494001786 1 probable transmembrane helix predicted for SSU0375 by TMHMM2.0 at aa 167-189 218494001787 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 218494001788 HMMPfam hit to PF02664, S-ribosylhomocysteinase (LuxS), score 1.6e-50 218494001789 hypothetical protein; Provisional; Region: PRK00106 218494001790 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 218494001791 1 probable transmembrane helix predicted for SSU0377 by TMHMM2.0 at aa 2-24 218494001792 HMMPfam hit to PF00013, K Homology, type 1, score 1.1e-08 218494001793 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 1.4e-25 218494001794 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 218494001795 catalytic site [active] 218494001796 G-X2-G-X-G-K; other site 218494001797 HMMPfam hit to PF00625, Guanylate kinase, score 1.2e-47 218494001798 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 218494001799 HMMPfam hit to PF01192, RNA polymerase Rpb6, score 2.7e-16 218494001800 primosome assembly protein PriA; Validated; Region: PRK05580 218494001801 primosome assembly protein PriA; Validated; Region: PRK05580 218494001802 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218494001803 ATP binding site [chemical binding]; other site 218494001804 putative Mg++ binding site [ion binding]; other site 218494001805 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218494001806 nucleotide binding region [chemical binding]; other site 218494001807 ATP-binding site [chemical binding]; other site 218494001808 HMMPfam hit to PF04851, Restriction endonuclease, type I, R subunit/Type III, Res subunit, score 1.3e-30 218494001809 PS00018 EF-hand calcium-binding domain. 218494001810 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001811 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 7.2e-10 218494001812 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 218494001813 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 218494001814 putative active site [active] 218494001815 substrate binding site [chemical binding]; other site 218494001816 putative cosubstrate binding site; other site 218494001817 catalytic site [active] 218494001818 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 218494001819 substrate binding site [chemical binding]; other site 218494001820 HMMPfam hit to PF00551, Formyl transferase, N-terminal, score 7.1e-38 218494001821 HMMPfam hit to PF02911, Formyl transferase, C-terminal, score 2.7e-34 218494001822 16S rRNA methyltransferase B; Provisional; Region: PRK14902 218494001823 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 218494001824 putative RNA binding site [nucleotide binding]; other site 218494001825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 218494001826 HMMPfam hit to PF01029, NusB/RsmB/TIM44, score 4.1e-35 218494001827 HMMPfam hit to PF01189, Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, score 2.3e-49 218494001828 PS01153 NOL1/NOP2/sun family signature. 218494001829 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 218494001830 active site 218494001831 HMMPfam hit to PF00481, Protein phosphatase 2C, N-terminal, score 3.9e-06 218494001832 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 218494001833 Catalytic domain of Protein Kinases; Region: PKc; cd00180 218494001834 active site 218494001835 ATP binding site [chemical binding]; other site 218494001836 substrate binding site [chemical binding]; other site 218494001837 activation loop (A-loop); other site 218494001838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 218494001839 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 218494001840 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 218494001841 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 218494001842 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 218494001843 HMMPfam hit to PF00069, Protein kinase, core, score 2e-62 218494001844 PS00107 Protein kinases ATP-binding region signature. 218494001845 PS00108 Serine/Threonine protein kinases active-site signature. 218494001846 HMMPfam hit to PF03793, PASTA, score 1.7e-12 218494001847 HMMPfam hit to PF03793, PASTA, score 1.7e-15 218494001848 HMMPfam hit to PF03793, PASTA, score 6.8e-14 218494001849 HMMPfam hit to PF03793, PASTA, score 8.2e-09 218494001850 Predicted membrane protein (DUF2154); Region: DUF2154; cl12089 218494001851 3 probable transmembrane helices predicted for SSU0386 by TMHMM2.0 at aa 7-24, 29-46 and 58-80 218494001852 Histidine kinase; Region: HisKA_3; pfam07730 218494001853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218494001854 ATP binding site [chemical binding]; other site 218494001855 Mg2+ binding site [ion binding]; other site 218494001856 G-X-G motif; other site 218494001857 2 probable transmembrane helices predicted for SSU0387 by TMHMM2.0 at aa 7-29 and 44-66 218494001858 HMMPfam hit to PF07730, Histidine kinase, dimerisation and phosphoacceptor region, score 1.2e-20 218494001859 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.3e-15 218494001860 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 218494001861 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218494001862 active site 218494001863 phosphorylation site [posttranslational modification] 218494001864 intermolecular recognition site; other site 218494001865 dimerization interface [polypeptide binding]; other site 218494001866 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218494001867 DNA binding residues [nucleotide binding] 218494001868 dimerization interface [polypeptide binding]; other site 218494001869 HMMPfam hit to PF00072, Response regulator receiver, score 2.6e-30 218494001870 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 5.3e-23 218494001871 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218494001872 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 218494001873 active site 218494001874 motif I; other site 218494001875 motif II; other site 218494001876 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 218494001877 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 218494001878 active site 218494001879 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 5.5e-71 218494001880 PS01229 Hypothetical cof family signature 2. 218494001881 HMMPfam hit to PF00160, Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, score 1.8e-52 218494001882 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 218494001883 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 218494001884 RNA binding site [nucleotide binding]; other site 218494001885 HMMPfam hit to PF00575, S1, RNA binding, score 1.5e-19 218494001886 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 218494001887 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 218494001888 dimer interface [polypeptide binding]; other site 218494001889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218494001890 catalytic residue [active] 218494001891 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 6.5e-115 218494001892 PS00901 Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. 218494001893 Uncharacterized conserved protein [Function unknown]; Region: COG1739 218494001894 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 218494001895 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 218494001896 HMMPfam hit to PF01205, Protein of unknown function UPF0029, N-terminal, score 2.8e-60 218494001897 PS00910 Uncharacterized protein family UPF0029 signature. 218494001898 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 218494001899 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218494001900 ATP binding site [chemical binding]; other site 218494001901 putative Mg++ binding site [ion binding]; other site 218494001902 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218494001903 nucleotide binding region [chemical binding]; other site 218494001904 ATP-binding site [chemical binding]; other site 218494001905 HMMPfam hit to PF04851, Restriction endonuclease, type I, R subunit/Type III, Res subunit, score 1.9e-05 218494001906 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001907 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 8.6e-11 218494001908 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 218494001909 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 218494001910 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 218494001911 30S subunit binding site; other site 218494001912 HMMPfam hit to PF02482, Ribosomal protein S30Ae/sigma 54 modulation protein, score 1.8e-30 218494001913 TRAM domain; Region: TRAM; cl01282 218494001914 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 218494001915 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218494001916 S-adenosylmethionine binding site [chemical binding]; other site 218494001917 HMMPfam hit to PF05958, (Uracil-5)-methyltransferase, score 1.3e-06 218494001918 PS01230 RNA methyltransferase trmA family signature 1. 218494001919 HMMPfam hit to PF01938, Deoxyribonuclease/rho motif-related TRAM, score 2.1e-07 218494001920 RecX family; Region: RecX; cl00936 218494001921 HMMPfam hit to PF02631, Regulatory protein RecX, score 9.5e-09 218494001922 Protein of unknown function (DUF402); Region: DUF402; cl00979 218494001923 HMMPfam hit to PF04167, Protein of unknown function DUF402, score 6.8e-41 218494001924 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 218494001925 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 218494001926 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218494001927 DNA-binding site [nucleotide binding]; DNA binding site 218494001928 UTRA domain; Region: UTRA; cl01230 218494001929 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 7.5e-18 218494001930 Predicted helix-turn-helix motif with score 1087.000, SD 2.89 at aa 33-54, sequence FSERELTQVYGVSRITVRLALQ 218494001931 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 3.6e-51 218494001932 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 218494001933 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218494001934 DNA-binding site [nucleotide binding]; DNA binding site 218494001935 UTRA domain; Region: UTRA; cl01230 218494001936 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 6.7e-16 218494001937 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 2.2e-14 218494001938 PS00012 Phosphopantetheine attachment site. 218494001939 Predicted helix-turn-helix motif with score 1054.000, SD 2.78 at aa 29-50, sequence YTESELTKLFNVSSITVIRAVN 218494001940 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 218494001941 HMMPfam hit to PF01301, Glycoside hydrolase, family 35, score 1.5e-177 218494001942 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 218494001943 active site 218494001944 phosphorylation site [posttranslational modification] 218494001945 HMMPfam hit to PF03830, Phosphotransferase system, sorbose subfamily IIB component, score 2.9e-74 218494001946 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 218494001947 HMMPfam hit to PF03609, Phosphotransferase system, sorbose-specific IIC subunit, score 1.1e-09 218494001948 7 probable transmembrane helices predicted for SSU0404 by TMHMM2.0 at aa 20-39, 46-68, 92-114, 147-169, 179-201, 214-236 and 251-273 218494001949 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 218494001950 HMMPfam hit to PF03613, Phosphotransferase system, mannose/fructose/sorbose family IID component, score 5.1e-119 218494001951 3 probable transmembrane helices predicted for SSU0405 by TMHMM2.0 at aa 177-199, 219-241 and 248-270 218494001952 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 218494001953 active pocket/dimerization site; other site 218494001954 active site 218494001955 phosphorylation site [posttranslational modification] 218494001956 HMMPfam hit to PF03610, Phosphotransferase system, fructose subfamily IIA component, score 1.2e-25 218494001957 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 218494001958 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 218494001959 active site 218494001960 catalytic residues [active] 218494001961 HMMPfam hit to PF01263, Aldose 1-epimerase, score 2.2e-82 218494001962 PS00545 Aldose 1-epimerase active site. 218494001963 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 218494001964 HMMPfam hit to PF08930, Protein of unknown function DUF1912, score 8.6e-61 218494001965 Rad51 protein; Provisional; Region: PTZ00035 218494001966 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 218494001967 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 218494001968 putative dimer interface [polypeptide binding]; other site 218494001969 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 218494001970 ligand binding site [chemical binding]; other site 218494001971 Zn binding site [ion binding]; other site 218494001972 HMMPfam hit to PF00903, Glyoxalase/bleomycin resistance protein/dioxygenase, score 0.00029 218494001973 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 218494001974 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 218494001975 active site 218494001976 HIGH motif; other site 218494001977 nucleotide binding site [chemical binding]; other site 218494001978 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 218494001979 active site 218494001980 KMSKS motif; other site 218494001981 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 218494001982 tRNA binding surface [nucleotide binding]; other site 218494001983 anticodon binding site; other site 218494001984 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 218494001985 HMMPfam hit to PF00133, Aminoacyl-tRNA synthetase, class Ia, score 0 218494001986 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218494001987 PS00017 ATP/GTP-binding site motif A (P-loop). 218494001988 HMMPfam hit to PF08264, Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding, score 3e-63 218494001989 6 probable transmembrane helices predicted for SSU0413 by TMHMM2.0 at aa 20-42, 44-63, 67-85, 102-124, 139-161 and 227-249 218494001990 Probable gene remnant. Similar to the C-terminal region of Streptococcus pyogenes (serotype M3) valine-tRNA ligase ValS UniProt:Q8K6M9 (EMBL:AE014161) (882 aa) fasta scores: E()=3.6e-05, 91.667% id in 24 aa 218494001991 Fic/DOC family; Region: Fic; cl00960 218494001992 HMMPfam hit to PF02661, Filamentation induced by cAMP protein Fic, score 3.3e-11 218494001993 PS00659 Glycosyl hydrolases family 5 signature. 218494001994 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 218494001995 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 218494001996 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218494001997 ATP binding site [chemical binding]; other site 218494001998 putative Mg++ binding site [ion binding]; other site 218494001999 C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126 218494002000 HMMPfam hit to PF01896, DNA primase, small subunit, score 8.5e-06 218494002001 HMMPfam hit to PF04851, Restriction endonuclease, type I, R subunit/Type III, Res subunit, score 7e-30 218494002002 PS00017 ATP/GTP-binding site motif A (P-loop). 218494002003 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218494002004 non-specific DNA binding site [nucleotide binding]; other site 218494002005 salt bridge; other site 218494002006 sequence-specific DNA binding site [nucleotide binding]; other site 218494002007 Domain of unknown function (DUF955); Region: DUF955; cl01076 218494002008 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 3e-10 218494002009 Predicted helix-turn-helix motif with score 1677.000, SD 4.90 at aa 16-37, sequence LTRADLARELEVTEQAIWQFET 218494002010 HMMPfam hit to PF06114, Protein of unknown function DUF955, score 1.1e-23 218494002011 Predicted helix-turn-helix motif with score 995.000, SD 2.58 at aa 336-357, sequence LTLSDIERNQRVSKNFISQLFS 218494002012 Protein of unknown function (DUF419); Region: DUF419; cl15265 218494002013 HMMPfam hit to PF04237, Protein of unknown function DUF419, score 1.5e-32 218494002014 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 218494002015 dimer interface [polypeptide binding]; other site 218494002016 active site 218494002017 HMMPfam hit to PF03590, Aspartate--ammonia ligase, score 3.4e-181 218494002018 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 218494002019 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 218494002020 G1 box; other site 218494002021 putative GEF interaction site [polypeptide binding]; other site 218494002022 GTP/Mg2+ binding site [chemical binding]; other site 218494002023 Switch I region; other site 218494002024 G2 box; other site 218494002025 G3 box; other site 218494002026 Switch II region; other site 218494002027 G4 box; other site 218494002028 G5 box; other site 218494002029 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 218494002030 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 218494002031 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 2.9e-67 218494002032 PS00017 ATP/GTP-binding site motif A (P-loop). 218494002033 PS00301 GTP-binding elongation factors signature. 218494002034 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 6.8e-17 218494002035 HMMPfam hit to PF00679, Translation elongation factor EFG/EF2, C-terminal, score 1.2e-27 218494002036 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 218494002037 3 probable transmembrane helices predicted for SSU0422 by TMHMM2.0 at aa 2-18, 28-50 and 57-74 218494002038 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 218494002039 Catalytic site [active] 218494002040 1 probable transmembrane helix predicted for SSU0424 by TMHMM2.0 at aa 39-61 218494002041 HMMPfam hit to PF00717, Peptidase S24, S26A and S26B, C-terminal, score 2.5e-13 218494002042 PS00761 Signal peptidases I signature 3. 218494002043 CDS contains a nonsense mutation (ochre) after codon 49. Internal region is similar to the N-terminal region of Listeria monocytogenes internalin A precursorinla InlA UniProt:P25146 (EMBL:LMO012346) (800 aa) blastp scores: E()=4e-09 218494002044 1 probable transmembrane helix predicted for SSU0425 by TMHMM2.0 at aa 20-42 218494002045 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494002046 1 probable transmembrane helix predicted for SSU0426 by TMHMM2.0 at aa 1580-1599 218494002047 Gram positive anchor; Region: Gram_pos_anchor; cl15427 218494002048 2 probable transmembrane helices predicted for SSU0427 by TMHMM2.0 at aa 7-29 and 450-472 218494002049 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 7.4e-11 218494002050 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 1.4e-05 218494002051 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494002052 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 218494002053 active site 218494002054 catalytic site [active] 218494002055 2 probable transmembrane helices predicted for SSU0428 by TMHMM2.0 at aa 12-34 and 244-266 218494002056 HMMPfam hit to PF04203, Peptidase C60, sortase A and B, score 8.2e-62 218494002057 Probable gene remnant. Similar to the N-terminal region of Streptococcus mutans transposase UniProt:Q93UN9 (EMBL:AF068251) (297 aa) fasta scores: E()=2e-19, 55.000% id in 100 aa 218494002058 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 218494002059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494002060 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218494002061 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218494002062 HMMPfam hit to PF08245, Mur ligase, central, score 8.5e-62 218494002063 HMMPfam hit to PF02875, Mur ligase, C-terminal, score 1.3e-19 218494002064 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 218494002065 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 218494002066 homodimer interface [polypeptide binding]; other site 218494002067 active site 218494002068 HMMPfam hit to PF03033, Glycosyl transferase, family 28, score 1.2e-39 218494002069 HMMPfam hit to PF04101, Glycosyltransferase 28, C-terminal, score 3.5e-27 218494002070 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 218494002071 Cell division protein FtsQ; Region: FtsQ; pfam03799 218494002072 1 probable transmembrane helix predicted for SSU0432 by TMHMM2.0 at aa 136-158 218494002073 HMMPfam hit to PF08478, Polypeptide-transport-associated, FtsQ-type, score 7.4e-15 218494002074 HMMPfam hit to PF03799, Cell division protein FtsQ, score 7.8e-12 218494002075 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 218494002076 Cell division protein FtsA; Region: FtsA; cl11496 218494002077 Cell division protein FtsA; Region: FtsA; cl11496 218494002078 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 218494002079 HMMPfam hit to PF02491, Cell division protein FtsA, score 5.9e-64 218494002080 HMMPfam hit to PF02491, Cell division protein FtsA, score 2e-50 218494002081 cell division protein FtsZ; Validated; Region: PRK09330 218494002082 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 218494002083 nucleotide binding site [chemical binding]; other site 218494002084 SulA interaction site; other site 218494002085 HMMPfam hit to PF00091, Tubulin/FtsZ, GTPase, score 1.2e-95 218494002086 PS01134 FtsZ protein signature 1. 218494002087 HMMPfam hit to PF03953, Tubulin/FtsZ, C-terminal, score 3.3e-25 218494002088 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 218494002089 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 218494002090 catalytic residue [active] 218494002091 HMMPfam hit to PF01168, Alanine racemase, N-terminal, score 1.1e-07 218494002092 Protein of unknown function (DUF552); Region: DUF552; cl00775 218494002093 HMMPfam hit to PF04472, Protein of unknown function DUF552, score 8.6e-28 218494002094 YGGT family; Region: YGGT; cl00508 218494002095 HMMPfam hit to PF02325, Protein of unknown function YGGT, score 7.9e-20 218494002096 2 probable transmembrane helices predicted for SSU0437 by TMHMM2.0 at aa 5-27 and 64-86 218494002097 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 218494002098 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218494002099 RNA binding surface [nucleotide binding]; other site 218494002100 HMMPfam hit to PF01479, RNA-binding S4, score 9.8e-08 218494002101 DivIVA protein; Region: DivIVA; pfam05103 218494002102 DivIVA domain; Region: DivI1A_domain; TIGR03544 218494002103 HMMPfam hit to PF05103, DivIVA, score 7.1e-66 218494002104 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218494002105 Coenzyme A binding pocket [chemical binding]; other site 218494002106 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 4.7e-11 218494002107 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 218494002108 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 218494002109 active site 218494002110 HIGH motif; other site 218494002111 nucleotide binding site [chemical binding]; other site 218494002112 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 218494002113 active site 218494002114 KMSKS motif; other site 218494002115 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 218494002116 tRNA binding surface [nucleotide binding]; other site 218494002117 anticodon binding site; other site 218494002118 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 218494002119 HMMPfam hit to PF00133, Aminoacyl-tRNA synthetase, class Ia, score 5.5e-273 218494002120 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218494002121 HMMPfam hit to PF08264, Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding, score 1.8e-52 218494002122 HMMPfam hit to PF06827, Formamidopyrimidine-DNA glycolase, C-terminal, score 8.4e-09 218494002123 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 218494002124 HMMPfam hit to PF08860, Protein of unknown function DUF1827, score 6.3e-58 218494002125 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 218494002126 nudix motif; other site 218494002127 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 1.7e-19 218494002128 PS00893 mutT domain signature. 218494002129 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 218494002130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218494002131 Walker A motif; other site 218494002132 ATP binding site [chemical binding]; other site 218494002133 Walker B motif; other site 218494002134 arginine finger; other site 218494002135 UvrB/uvrC motif; Region: UVR; pfam02151 218494002136 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218494002137 Walker A motif; other site 218494002138 ATP binding site [chemical binding]; other site 218494002139 Walker B motif; other site 218494002140 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 218494002141 HMMPfam hit to PF07724, ATPase AAA-2, score 6.3e-98 218494002142 PS00871 Chaperonins clpA/B signature 2. 218494002143 PS00017 ATP/GTP-binding site motif A (P-loop). 218494002144 HMMPfam hit to PF02151, UvrB/UvrC protein, score 0.0014 218494002145 PS00870 Chaperonins clpA/B signature 1. 218494002146 HMMPfam hit to PF00004, AAA ATPase, core, score 2.8e-12 218494002147 PS00017 ATP/GTP-binding site motif A (P-loop). 218494002148 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 218494002149 HMMPfam hit to PF08796, Protein of unknown function DUF1797, score 1.7e-33 218494002150 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218494002151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494002152 dimer interface [polypeptide binding]; other site 218494002153 conserved gate region; other site 218494002154 putative PBP binding loops; other site 218494002155 ABC-ATPase subunit interface; other site 218494002156 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 8.2e-32 218494002157 3 probable transmembrane helices predicted for SSU0446 by TMHMM2.0 at aa 15-37, 57-79 and 191-213 218494002158 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218494002159 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 218494002160 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 218494002161 Walker A/P-loop; other site 218494002162 ATP binding site [chemical binding]; other site 218494002163 Q-loop/lid; other site 218494002164 ABC transporter signature motif; other site 218494002165 Walker B; other site 218494002166 D-loop; other site 218494002167 H-loop/switch region; other site 218494002168 HMMPfam hit to PF00005, ABC transporter related, score 1.5e-68 218494002169 PS00017 ATP/GTP-binding site motif A (P-loop). 218494002170 PS00211 ABC transporters family signature. 218494002171 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 218494002172 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 218494002173 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 218494002174 homodimer interface [polypeptide binding]; other site 218494002175 NADP binding site [chemical binding]; other site 218494002176 substrate binding site [chemical binding]; other site 218494002177 HMMPfam hit to PF00763, Tetrahydrofolate dehydrogenase/cyclohydrolase, score 2.3e-57 218494002178 HMMPfam hit to PF02882, Tetrahydrofolate dehydrogenase/cyclohydrolase, score 2.2e-106 218494002179 PS00767 Tetrahydrofolate dehydrogenase/cyclohydrolase signature 2. 218494002180 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 218494002181 Catalytic site [active] 218494002182 1 probable transmembrane helix predicted for SSU0450 by TMHMM2.0 at aa 43-65 218494002183 HMMPfam hit to PF00717, Peptidase S24, S26A and S26B, C-terminal, score 2.9e-10 218494002184 PS00761 Signal peptidases I signature 3. 218494002185 1 probable transmembrane helix predicted for SSU0451 by TMHMM2.0 at aa 24-46 218494002186 Probable gene remnant. Similar to the C-terminal region of Lactobacillus helveticus ISl2 mobile genetic element protein UniProt:Q48559 (EMBL:LHISL2) (268 aa) fasta scores: E()=1.2e-13, 44.167% id in 120 aa 218494002187 HMMPfam hit to PF01609, Transposase, IS4-like, score 0.0035 218494002188 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 218494002189 active site 218494002190 catalytic site [active] 218494002191 2 probable transmembrane helices predicted for SSU0453 by TMHMM2.0 at aa 9-28 and 247-266 218494002192 HMMPfam hit to PF04203, Peptidase C60, sortase A and B, score 3.6e-58 218494002193 Probable gene remnant. Similar to the C-terminal region of Enterococcus faecalis (Streptococcus faecalis) hypothetical protein UniProt:Q835N7 (EMBL:AE016951) (153 aa) fasta scores: E()=4.6e-11, 66.667% id in 57 aa 218494002194 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 218494002195 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 218494002196 DNA binding residues [nucleotide binding] 218494002197 putative dimer interface [polypeptide binding]; other site 218494002198 Predicted helix-turn-helix motif with score 1649.000, SD 4.80 at aa 3-24, sequence MNIKEVSDVTGLSADTIRYYER 218494002199 HMMPfam hit to PF00376, Bacterial regulatory protein, MerR, score 3.7e-11 218494002200 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 218494002201 2 probable transmembrane helices predicted for SSU0456 by TMHMM2.0 at aa 41-60 and 64-86 218494002202 Peptidase family U32; Region: Peptidase_U32; cl03113 218494002203 HMMPfam hit to PF01136, Peptidase U32, score 9.7e-74 218494002204 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 218494002205 Peptidase family U32; Region: Peptidase_U32; cl03113 218494002206 HMMPfam hit to PF01136, Peptidase U32, score 6.8e-128 218494002207 PS01276 Peptidase family U32 signature. 218494002208 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; cl01839 218494002209 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 218494002210 HMMPfam hit to PF02632, BioY protein, score 4.1e-27 218494002211 4 probable transmembrane helices predicted for SSU0462 by TMHMM2.0 at aa 7-29, 53-75, 77-99 and 109-131 218494002212 Putative cyclase; Region: Cyclase; cl00814 218494002213 HMMPfam hit to PF04199, cyclase, score 1.3e-52 218494002214 glutathione reductase; Validated; Region: PRK06116 218494002215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494002216 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 218494002217 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidoreductase dimerisation region, score 1.5e-47 218494002218 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 1.6e-59 218494002219 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 1.8e-27 218494002220 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 218494002221 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 218494002222 1 probable transmembrane helix predicted for SSU0465 by TMHMM2.0 at aa 7-29 218494002223 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 218494002224 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 218494002225 Walker A/P-loop; other site 218494002226 ATP binding site [chemical binding]; other site 218494002227 Q-loop/lid; other site 218494002228 ABC transporter signature motif; other site 218494002229 Walker B; other site 218494002230 D-loop; other site 218494002231 H-loop/switch region; other site 218494002232 HMMPfam hit to PF00005, ABC transporter related, score 4.3e-57 218494002233 PS00017 ATP/GTP-binding site motif A (P-loop). 218494002234 PS00211 ABC transporters family signature. 218494002235 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 218494002236 FtsX-like permease family; Region: FtsX; pfam02687 218494002237 4 probable transmembrane helices predicted for SSU0467 by TMHMM2.0 at aa 20-42, 288-310, 330-361 and 376-398 218494002238 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 3.8e-49 218494002239 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 218494002240 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 218494002241 HMMPfam hit to PF00296, Bacterial luciferase-like, score 2.4e-22 218494002242 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 218494002243 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 218494002244 dimer interface [polypeptide binding]; other site 218494002245 putative anticodon binding site; other site 218494002246 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 218494002247 motif 1; other site 218494002248 active site 218494002249 motif 2; other site 218494002250 motif 3; other site 218494002251 HMMPfam hit to PF00152, Aminoacyl-tRNA synthetase, class II (D, K and N), score 7.1e-119 218494002252 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218494002253 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 218494002254 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 8.1e-20 218494002255 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 218494002256 catalytic core [active] 218494002257 HMMPfam hit to PF00300, Phosphoglycerate mutase, score 3.5e-43 218494002258 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 218494002259 putative deacylase active site [active] 218494002260 HMMPfam hit to PF04073, YbaK/prolyl-tRNA synthetase associated region, score 7e-54 218494002261 Domain of unknown function (DUF368); Region: DUF368; cl00893 218494002262 8 probable transmembrane helices predicted for SSU0473 by TMHMM2.0 at aa 12-34, 54-76, 83-100, 115-132, 139-161, 186-205, 218-237 and 252-271 218494002263 HMMPfam hit to PF04018, Protein of unknown function DUF368, score 3.9e-107 218494002264 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 218494002265 5 probable transmembrane helices predicted for SSU0474 by TMHMM2.0 at aa 25-47, 52-74, 79-101, 114-136 and 151-173 218494002266 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 218494002267 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 218494002268 active site 218494002269 HMMPfam hit to PF01183, Glycoside hydrolase, family 25, score 7.6e-07 218494002270 1 probable transmembrane helix predicted for SSU0475 by TMHMM2.0 at aa 2-24 218494002271 4 probable transmembrane helices predicted for SSU0476 by TMHMM2.0 at aa 13-35, 45-67, 74-96 and 106-128 218494002272 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494002273 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 218494002274 8 probable transmembrane helices predicted for SSU0478 by TMHMM2.0 at aa 9-31, 46-65, 77-96, 170-192, 199-221, 299-321, 334-356 and 361-383 218494002275 HMMPfam hit to PF01098, Cell cycle protein, score 7.3e-83 218494002276 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 218494002277 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 218494002278 HMMPfam hit to PF00311, Phosphoenolpyruvate carboxylase, score 1.6e-92 218494002279 PS00393 Phosphoenolpyruvate carboxylase active site 2. 218494002280 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 218494002281 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 218494002282 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 218494002283 DNA binding residues [nucleotide binding] 218494002284 HMMPfam hit to PF04542, RNA polymerase sigma-70 region 2, score 0.00024 218494002285 HMMPfam hit to PF08281, RNA polymerase sigma factor 70, region 4 type 2, score 7.3e-15 218494002286 Predicted helix-turn-helix motif with score 1396.000, SD 3.94 at aa 126-147, sequence MSIKEIAHILGAGQSWVKISLH 218494002287 1 probable transmembrane helix predicted for SSU0481 by TMHMM2.0 at aa 20-42 218494002288 elongation factor Tu; Reviewed; Region: PRK00049 218494002289 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 218494002290 G1 box; other site 218494002291 GEF interaction site [polypeptide binding]; other site 218494002292 GTP/Mg2+ binding site [chemical binding]; other site 218494002293 Switch I region; other site 218494002294 G2 box; other site 218494002295 G3 box; other site 218494002296 Switch II region; other site 218494002297 G4 box; other site 218494002298 G5 box; other site 218494002299 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 218494002300 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 218494002301 Antibiotic Binding Site [chemical binding]; other site 218494002302 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 4.9e-101 218494002303 PS00017 ATP/GTP-binding site motif A (P-loop). 218494002304 PS00301 GTP-binding elongation factors signature. 218494002305 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 1.5e-23 218494002306 HMMPfam hit to PF03143, Translation elongation factor EFTu/EF1A, C-terminal, score 2e-60 218494002307 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 218494002308 substrate binding site [chemical binding]; other site 218494002309 dimer interface [polypeptide binding]; other site 218494002310 catalytic triad [active] 218494002311 HMMPfam hit to PF00121, Triosephosphate isomerase, score 3.3e-132 218494002312 PS00171 Triosephosphate isomerase active site. 218494002313 sugar phosphate phosphatase; Provisional; Region: PRK10513 218494002314 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218494002315 active site 218494002316 motif I; other site 218494002317 motif II; other site 218494002318 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 218494002319 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 5.8e-103 218494002320 PS01229 Hypothetical cof family signature 2. 218494002321 PS01228 Hypothetical cof family signature 1. 218494002322 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 218494002323 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 218494002324 Zn2+ binding site [ion binding]; other site 218494002325 Mg2+ binding site [ion binding]; other site 218494002326 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 2.1e-08 218494002327 8 probable transmembrane helices predicted for SSU0486 by TMHMM2.0 at aa 5-27, 40-62, 96-118, 139-156, 171-193, 200-222, 242-264 and 271-290 218494002328 HMMPfam hit to PF01925, Protein of unknown function DUF81, score 2.2e-08 218494002329 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 218494002330 HMMPfam hit to PF09148, Protein of unknown function DUF1934, score 5.6e-08 218494002331 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 218494002332 Integrase core domain; Region: rve; cl01316 218494002333 HMMPfam hit to PF00665, Integrase, catalytic core, score 9.1e-14 218494002334 Predicted helix-turn-helix motif with score 1377.000, SD 3.88 at aa 22-43, sequence KPFSAIAAKLGKDPSTISKEVR 218494002335 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 218494002336 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 218494002337 active site 218494002338 HMMPfam hit to PF00962, Adenosine/AMP deaminase, score 1.6e-48 218494002339 6 probable transmembrane helices predicted for SSU0490 by TMHMM2.0 at aa 16-38, 58-80, 115-137, 157-179, 192-214 and 229-251 218494002340 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 218494002341 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 218494002342 Walker A/P-loop; other site 218494002343 ATP binding site [chemical binding]; other site 218494002344 Q-loop/lid; other site 218494002345 ABC transporter signature motif; other site 218494002346 Walker B; other site 218494002347 D-loop; other site 218494002348 H-loop/switch region; other site 218494002349 HMMPfam hit to PF00005, ABC transporter related, score 1.9e-33 218494002350 PS00017 ATP/GTP-binding site motif A (P-loop). 218494002351 Predicted transcriptional regulators [Transcription]; Region: COG1725 218494002352 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218494002353 DNA-binding site [nucleotide binding]; DNA binding site 218494002354 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 5.3e-13 218494002355 Predicted helix-turn-helix motif with score 1665.000, SD 4.86 at aa 37-58, sequence PTVRDLAEIAGVNPNTVQRALS 218494002356 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 218494002357 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 218494002358 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 218494002359 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 218494002360 generic binding surface II; other site 218494002361 generic binding surface I; other site 218494002362 HMMPfam hit to PF02811, PHP, C-terminal, score 2e-14 218494002363 HMMPfam hit to PF07733, Bacterial DNA polymerase III, alpha subunit, score 2.8e-244 218494002364 Predicted helix-turn-helix motif with score 1040.000, SD 2.73 at aa 875-896, sequence RSFTDLADLAVGNRATVLVQIQ 218494002365 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 7.5e-10 218494002366 6-phosphofructokinase; Provisional; Region: PRK03202 218494002367 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 218494002368 active site 218494002369 ADP/pyrophosphate binding site [chemical binding]; other site 218494002370 dimerization interface [polypeptide binding]; other site 218494002371 allosteric effector site; other site 218494002372 fructose-1,6-bisphosphate binding site; other site 218494002373 HMMPfam hit to PF00365, Phosphofructokinase, score 1.4e-182 218494002374 PS00433 Phosphofructokinase signature. 218494002375 pyruvate kinase; Provisional; Region: PRK05826 218494002376 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 218494002377 domain interfaces; other site 218494002378 active site 218494002379 HMMPfam hit to PF00224, Pyruvate kinase, barrel, score 1.5e-208 218494002380 HMMPfam hit to PF02887, Pyruvate kinase, alpha/beta, score 7.8e-49 218494002381 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 218494002382 Mac 1; Region: Mac-1; pfam09028 218494002383 HMMPfam hit to PF09028, Mac 1, score 1.3e-257 218494002384 1 probable transmembrane helix predicted for SSU0496 by TMHMM2.0 at aa 1119-1136 218494002385 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 218494002386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494002387 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 9.9e-65 218494002388 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 218494002389 active site 218494002390 catalytic triad [active] 218494002391 oxyanion hole [active] 218494002392 HMMPfam hit to PF00657, Lipolytic enzyme, G-D-S-L, score 3.3e-14 218494002393 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 218494002394 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 218494002395 1 probable transmembrane helix predicted for SSU0499 by TMHMM2.0 at aa 12-34 218494002396 HMMPfam hit to PF00717, Peptidase S24, S26A and S26B, C-terminal, score 0.017 218494002397 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 218494002398 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 218494002399 glutaminase active site [active] 218494002400 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 218494002401 dimer interface [polypeptide binding]; other site 218494002402 active site 218494002403 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 218494002404 dimer interface [polypeptide binding]; other site 218494002405 active site 218494002406 PS00443 Glutamine amidotransferases class-II active site. 218494002407 HMMPfam hit to PF00310, Glutamine amidotransferase, class-II, score 1.4e-32 218494002408 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 1.2e-29 218494002409 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 1.1e-15 218494002410 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218494002411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494002412 dimer interface [polypeptide binding]; other site 218494002413 conserved gate region; other site 218494002414 putative PBP binding loops; other site 218494002415 ABC-ATPase subunit interface; other site 218494002416 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.1e-28 218494002417 4 probable transmembrane helices predicted for SSU0501 by TMHMM2.0 at aa 15-37, 49-71, 86-103 and 179-201 218494002418 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218494002419 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 218494002420 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494002421 Walker A/P-loop; other site 218494002422 ATP binding site [chemical binding]; other site 218494002423 Q-loop/lid; other site 218494002424 ABC transporter signature motif; other site 218494002425 Walker B; other site 218494002426 D-loop; other site 218494002427 H-loop/switch region; other site 218494002428 HMMPfam hit to PF00005, ABC transporter related, score 5.5e-59 218494002429 PS00017 ATP/GTP-binding site motif A (P-loop). 218494002430 PS00211 ABC transporters family signature. 218494002431 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 218494002432 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218494002433 substrate binding pocket [chemical binding]; other site 218494002434 membrane-bound complex binding site; other site 218494002435 hinge residues; other site 218494002436 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494002437 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 4.1e-75 218494002438 Probable gene remnant. Similar to the C-terminal region of Geobacillus kaustophilus transposase UniProt:Q5KVU7 (EMBL:BA000043) (378 aa) fasta scores: E()=4.5e-05, 28.889% id in 90 aa 218494002439 Probable gene remnant. Similar to the N-terminal region of Streptococcus gordonii transposase UniProt:Q84AQ8 (EMBL:AY116209) (170 aa) fasta scores: E()=5.1e-05, 35.766% id in 137 aa 218494002440 Probable gene remnant. Similar to the C-terminal region of Streptococcus agalactiae transposase UniProt:Q9L9Q9 (EMBL:AF165983) (287 aa) fasta scores: E()=0.00035, 44.785% id in 163 aa 218494002441 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 218494002442 HMMPfam hit to PF00753, Beta-lactamase-like, score 1.8e-35 218494002443 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 218494002444 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 218494002445 active site 218494002446 substrate binding site [chemical binding]; other site 218494002447 catalytic site [active] 218494002448 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494002449 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494002450 HMMPfam hit to PF00929, Exonuclease, RNase T and DNA polymerase III, score 6.7e-35 218494002451 PS00017 ATP/GTP-binding site motif A (P-loop). 218494002452 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 0.0044 218494002453 gamma-glutamyl kinase; Provisional; Region: PRK05429 218494002454 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 218494002455 nucleotide binding site [chemical binding]; other site 218494002456 homotetrameric interface [polypeptide binding]; other site 218494002457 putative phosphate binding site [ion binding]; other site 218494002458 putative allosteric binding site; other site 218494002459 PUA domain; Region: PUA; cl00607 218494002460 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 1.3e-64 218494002461 PS00902 Glutamate 5-kinase signature. 218494002462 HMMPfam hit to PF01472, PUA, score 1.7e-17 218494002463 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 218494002464 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 218494002465 putative catalytic cysteine [active] 218494002466 HMMPfam hit to PF00171, Aldehyde dehydrogenase, score 1.4e-07 218494002467 PS01223 Gamma-glutamyl phosphate reductase signature. 218494002468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494002469 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 218494002470 HMMPfam hit to PF03807, NADP oxidoreductase, coenzyme F420-dependent, score 5.6e-61 218494002471 PS00521 Delta 1-pyrroline-5-carboxylate reductase signature. 218494002472 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 218494002473 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494002474 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 2.2e-07 218494002475 Predicted helix-turn-helix motif with score 1173.000, SD 3.18 at aa 45-66, sequence ISVSELVRKAGVSRNAFYRNYK 218494002476 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 218494002477 HMMPfam hit to PF02645, DegV, score 9.6e-67 218494002478 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218494002479 DNA-binding site [nucleotide binding]; DNA binding site 218494002480 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218494002481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218494002482 homodimer interface [polypeptide binding]; other site 218494002483 catalytic residue [active] 218494002484 PS00139 Eukaryotic thiol (cysteine) proteases cysteine active site. 218494002485 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 1.3e-05 218494002486 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 1.6e-10 218494002487 Protein of unknown function (DUF328); Region: DUF328; cl01143 218494002488 HMMPfam hit to PF03883, Protein of unknown function DUF328, score 1.8e-46 218494002489 3 probable transmembrane helices predicted for SSU0515 by TMHMM2.0 at aa 13-35, 45-66 and 73-92 218494002490 HMMPfam hit to PF02916, DNA polymerase processivity factor, score 8.6e-65 218494002491 HMMPfam hit to PF03816, Cell envelope-related transcriptional attenuator, score 2.1e-69 218494002492 Chain length determinant protein; Region: Wzz; cl01623 218494002493 HMMPfam hit to PF02706, Lipopolysaccharide biosynthesis, score 1.7e-50 218494002494 2 probable transmembrane helices predicted for SSU0516 by TMHMM2.0 at aa 25-47 and 178-200 218494002495 PS00217 Sugar transport proteins signature 2. 218494002496 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 218494002497 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494002498 HMMPfam hit to PF01656, Cobyrinic acid a,c-diamide synthase, score 5.1e-18 218494002499 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 218494002500 HMMPfam hit to PF02811, PHP, C-terminal, score 1e-29 218494002501 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 218494002502 Bacterial sugar transferase; Region: Bac_transf; cl00939 218494002503 5 probable transmembrane helices predicted for SSU0519 by TMHMM2.0 at aa 12-31, 35-52, 73-90, 100-119 and 271-293 218494002504 HMMPfam hit to PF02397, Bacterial sugar transferase, score 1e-143 218494002505 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 218494002506 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 218494002507 HMMPfam hit to PF09314, Protein of unknown function DUF1972, score 3.4e-139 218494002508 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 0.0048 218494002509 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 218494002510 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 218494002511 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 8.2e-34 218494002512 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 218494002513 active site 218494002514 PS00290 Immunoglobulins and major histocompatibility complex proteins signature. 218494002515 1 probable transmembrane helix predicted for SSU0523 by TMHMM2.0 at aa 416-438 218494002516 ZIP Zinc transporter; Region: Zip; pfam02535 218494002517 11 probable transmembrane helices predicted for SSU0524 by TMHMM2.0 at aa 7-29, 33-52, 59-81, 86-108, 121-143, 163-182, 195-217, 232-254, 274-296, 311-333 and 354-376 218494002518 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 218494002519 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 218494002520 active site 218494002521 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 1.5e-43 218494002522 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 218494002523 active site 218494002524 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 4.5e-51 218494002525 1 probable transmembrane helix predicted for SSU0526 by TMHMM2.0 at aa 293-315 218494002526 3 probable transmembrane helices predicted for SSU0527 by TMHMM2.0 at aa 5-27, 37-59 and 80-99 218494002527 1 probable transmembrane helix predicted for SSU0528 by TMHMM2.0 at aa 13-35 218494002528 Probable gene remnant. CDS is disrupted by a repeat, that is also found elsewhere the csp region. Similar to the N-terminal region of Streptococcus agalactiae (serotype V) N-acylneuraminate cytidylyltransferase (ec 2.7.7.43) (CMP-N acetylneuraminic acid synthetase) (CMP-NeuNAc synthetase) (CMP-siali acid synthetase) NeuA UniProt:Q9AFG9 (EMBL:AE014244) (413 aa) fasta scores: E()=7.3e-25, 57.246% id in 138 aa. Similar to the N-terminal region of SSU0538, 87.273% identity (87.273% ungapped) in 55 aa overlap (9-63:4-58) 218494002529 HMMPfam hit to PF02348, Acylneuraminate cytidylyltransferase, score 8.8e-25 218494002530 Glycosyltransferase family 52; Region: Glyco_transf_52; pfam07922 218494002531 HMMPfam hit to PF05855, Lipooligosaccharide sialyltransferase, score 1.7e-28 218494002532 MatE; Region: MatE; cl10513 218494002533 HMMPfam hit to PF01943, Polysaccharide biosynthesis protein, score 4.2e-22 218494002534 14 probable transmembrane helices predicted for SSU0534 by TMHMM2.0 at aa 7-29, 49-71, 83-105, 115-137, 144-166, 171-193, 206-225, 245-267, 288-310, 320-342, 349-371, 376-398, 407-429 and 433-451 218494002535 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 218494002536 NeuB family; Region: NeuB; cl00496 218494002537 SAF domain; Region: SAF; cl00555 218494002538 HMMPfam hit to PF03102, N-acetylneuraminic acid synthase, N-terminal, score 4.6e-144 218494002539 HMMPfam hit to PF08666, SAF domain, score 4.9e-10 218494002540 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 218494002541 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 218494002542 active site 218494002543 homodimer interface [polypeptide binding]; other site 218494002544 HMMPfam hit to PF02350, UDP-N-acetylglucosamine 2-epimerase, score 1.7e-95 218494002545 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 218494002546 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 218494002547 putative trimer interface [polypeptide binding]; other site 218494002548 putative CoA binding site [chemical binding]; other site 218494002549 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 13 218494002550 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.7 218494002551 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 6.4 218494002552 PS00101 Hexapeptide-repeat containing-transferases signature. 218494002553 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 58 218494002554 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 218494002555 ligand binding site; other site 218494002556 tetramer interface; other site 218494002557 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 218494002558 active site 218494002559 catalytic triad [active] 218494002560 oxyanion hole [active] 218494002561 HMMPfam hit to PF02348, Acylneuraminate cytidylyltransferase, score 2.4e-45 218494002562 HMMPfam hit to PF00657, Lipolytic enzyme, G-D-S-L, score 5.2e-06 218494002563 CDS contains a frameshift and deletion after codon 160. Similar to Streptococcus thermophilus IS1198 transposase UniProt:Q70C57 (EMBL:AR542664) (334 aa) blastp scores: E()=8e-82 218494002564 HMMPfam hit to PF01609, Transposase, IS4-like, score 0.003 218494002565 Transposase; Region: HTH_Tnp_IS630; pfam01710 218494002566 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 218494002567 HMMPfam hit to PF01710, Transposase, Synechocystis PCC 6803, score 6.5e-16 218494002568 Predicted helix-turn-helix motif with score 2164.000, SD 6.56 at aa 19-40, sequence GSITEASAIFQVSRNTIYQWLK 218494002569 Integrase core domain; Region: rve; cl01316 218494002570 Probable gene remnant. Similar to the C-terminal region of Streptococcus pneumoniae IS66 family element, Orf1 UniProt:Q97PZ4 (EMBL:AE007441) (79 aa) fasta scores: E()=8.5e-13, 63.934% id in 61 aa 218494002571 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 218494002572 HMMPfam hit to PF05717, Transposase (), IS66 Orf2 like, score 4.1e-35 218494002573 CDS contains frameshifts after codons 87, 356 and 380. Similar to Ruminococcus gnavus hypothetical protein UniProt:Q8VRK5 (EMBL:AF439554) (538 aa) fasta scores: E()=3.4e-28, 32.645% id in 533 aa 218494002574 HMMPfam hit to PF03050, Transposase, IS66, score 1.7e-11 218494002575 Probable gene remnant. Similar to the C-terminal region of Streptococcus thermophilus (strain CNRZ 1066) IS1239, transposase, IS30 family UniProt:Q5M0H3 (EMBL:CP000024) (332 aa) fasta scores: E()=4.8e-96, 94.253% id in 261 aa 218494002576 HMMPfam hit to PF00665, Integrase, catalytic core, score 6.6e-24 218494002577 Probable gene remnant. Similar to the C-terminal region of Streptococcus pneumoniae IS66 family element, Orf1 UniProt:Q97QB1 (EMBL:AE007429) (79 aa) fasta scores: E()=3.8e-11, 62.745% id in 51 aa 218494002578 Probable gene remnant. Similar to the N-terminal region of Streptococcus pneumoniae IS66 family element UniProt:Q7WVV7 (EMBL:AY336008) (116 aa) fasta scores: E()=0.00047, 88.235% id in 17 aa 218494002579 Probable gene remnant. Similar to an internal region of Methanobacterium thermoautotrophicum XerC-like tyrosine recombinase UniProt:O26979 (EMBL:AE000865) (311 aa) fasta scores: E()=4.6e-18, 47.222% id in 144 aa 218494002580 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 2.4e-21 218494002581 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 5.5e-13 218494002582 CDS contains nonsense (amber) and frameshift mutations after codons 51 and 182. The frameshift mutation occurs at a poly T hexamer. Similar to Aquifex aeolicus D-alanine--D-alanine ligase (ec 6.3.2.4) (D-alanylalanine synthetase (D-ala-D-ala ligase) Ddl UniProt:O66806 (EMBL:AE000694) (291 aa) fasta scores: E()=1.8e-05, 21.127% id in 284 aa 218494002583 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 218494002584 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 218494002585 putative active site [active] 218494002586 HMMPfam hit to PF00275, 3-phosphoshikimate 1-carboxyvinyltransferase, score 6.1e-142 218494002587 PS00104 EPSP synthase signature 1. 218494002588 shikimate kinase; Reviewed; Region: aroK; PRK00131 218494002589 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 218494002590 ADP binding site [chemical binding]; other site 218494002591 magnesium binding site [ion binding]; other site 218494002592 putative shikimate binding site; other site 218494002593 PS00017 ATP/GTP-binding site motif A (P-loop). 218494002594 HMMPfam hit to PF01202, Shikimate kinase, score 1.4e-54 218494002595 PS01128 Shikimate kinase signature. 218494002596 prephenate dehydratase; Provisional; Region: PRK11898 218494002597 Prephenate dehydratase; Region: PDT; pfam00800 218494002598 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 218494002599 putative L-Phe binding site [chemical binding]; other site 218494002600 HMMPfam hit to PF00800, Prephenate dehydratase, score 2e-65 218494002601 PS00858 Prephenate dehydratase signature 2. 218494002602 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 218494002603 1 probable transmembrane helix predicted for SSU0560 by TMHMM2.0 at aa 127-146 218494002604 HMMPfam hit to PF03816, Cell envelope-related transcriptional attenuator, score 4.6e-67 218494002605 TRAM domain; Region: TRAM; cl01282 218494002606 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 218494002607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218494002608 S-adenosylmethionine binding site [chemical binding]; other site 218494002609 HMMPfam hit to PF01938, Deoxyribonuclease/rho motif-related TRAM, score 8.7e-07 218494002610 HMMPfam hit to PF05958, (Uracil-5)-methyltransferase, score 2.3e-08 218494002611 PS00192 Cytochrome b/b6 heme-ligand signature. 218494002612 PS01230 RNA methyltransferase trmA family signature 1. 218494002613 Probable gene remnant. Similar to Streptococcus pneumoniae transposase. UniProt:O33754 (EMBL:SPZ86112) (271 aa) blastp scores: E()=4e-20 218494002614 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 218494002615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494002616 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 4.4e-06 218494002617 HMMPfam hit to PF03275, UDP-galactopyranose mutase, C-terminal, score 2.2e-115 218494002618 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 218494002619 HMMPfam hit to PF03358, NADPH-dependent FMN reductase, score 2.6e-25 218494002620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494002621 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 5.8e-18 218494002622 Transposase; Region: HTH_Tnp_IS630; pfam01710 218494002623 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 218494002624 HMMPfam hit to PF01710, Transposase, Synechocystis PCC 6803, score 6.5e-16 218494002625 Predicted helix-turn-helix motif with score 2164.000, SD 6.56 at aa 19-40, sequence GSITEASAIFQVSRNTIYQWLK 218494002626 Integrase core domain; Region: rve; cl01316 218494002627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 218494002628 Peptidase propeptide and YPEB domain; Region: PepSY; cl15480 218494002629 1 probable transmembrane helix predicted for SSU0568 by TMHMM2.0 at aa 20-42 218494002630 aspartate aminotransferase; Provisional; Region: PRK05764 218494002631 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218494002632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218494002633 homodimer interface [polypeptide binding]; other site 218494002634 catalytic residue [active] 218494002635 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 2.1e-89 218494002636 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 218494002637 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 218494002638 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 218494002639 putative dimer interface [polypeptide binding]; other site 218494002640 putative anticodon binding site; other site 218494002641 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 218494002642 homodimer interface [polypeptide binding]; other site 218494002643 motif 1; other site 218494002644 motif 2; other site 218494002645 active site 218494002646 motif 3; other site 218494002647 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 4.1e-19 218494002648 HMMPfam hit to PF00152, Aminoacyl-tRNA synthetase, class II (D, K and N), score 3e-98 218494002649 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 218494002650 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218494002651 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 218494002652 HMMPfam hit to PF05016, Plasmid stabilization system, score 9.8e-15 218494002653 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 218494002654 MatE; Region: MatE; cl10513 218494002655 MatE; Region: MatE; cl10513 218494002656 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 7.5e-39 218494002657 10 probable transmembrane helices predicted for SSU0573 by TMHMM2.0 at aa 26-48, 52-71, 91-113, 128-150, 163-182, 186-208, 249-271, 276-298, 310-332 and 404-426 218494002658 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 2e-28 218494002659 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 218494002660 homotrimer interaction site [polypeptide binding]; other site 218494002661 putative active site [active] 218494002662 HMMPfam hit to PF01042, Endoribonuclease L-PSP, score 1.4e-65 218494002663 PS01094 Uncharacterized protein family UPF0076 signature. 218494002664 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494002665 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 218494002666 HMMPfam hit to PF03668, P-loop ATPase protein, score 4e-130 218494002667 PS00017 ATP/GTP-binding site motif A (P-loop). 218494002668 PS00017 ATP/GTP-binding site motif A (P-loop). 218494002669 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 218494002670 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 218494002671 dimer interface [polypeptide binding]; other site 218494002672 phosphate binding site [ion binding]; other site 218494002673 HMMPfam hit to PF01933, Protein of unknown function UPF0052 and CofD, score 1.5e-141 218494002674 PS01036 Heat shock hsp70 proteins family signature 3. 218494002675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 218494002676 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 218494002677 HMMPfam hit to PF02650, Protein of unknown function DUF199, score 4.1e-71 218494002678 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 218494002679 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 218494002680 ligand binding site [chemical binding]; other site 218494002681 flexible hinge region; other site 218494002682 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494002683 HMMPfam hit to PF00027, Cyclic nucleotide-binding, score 3.1e-17 218494002684 HMMPfam hit to PF00325, Bacterial regulatory protein, Crp, score 5.2e-05 218494002685 Predicted helix-turn-helix motif with score 1622.000, SD 4.71 at aa 179-200, sequence IHIQEISRLAATTRETVSHVLK 218494002686 Amidinotransferase; Region: Amidinotransf; cl12043 218494002687 HMMPfam hit to PF02274, Amidinotransferase, score 4e-199 218494002688 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218494002689 Coenzyme A binding pocket [chemical binding]; other site 218494002690 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1e-10 218494002691 ornithine carbamoyltransferase; Validated; Region: PRK02102 218494002692 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 218494002693 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494002694 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding, score 7.8e-68 218494002695 PS00097 Aspartate and ornithine carbamoyltransferases signature. 218494002696 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region, score 7.3e-79 218494002697 carbamate kinase; Reviewed; Region: PRK12686 218494002698 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 218494002699 putative substrate binding site [chemical binding]; other site 218494002700 nucleotide binding site [chemical binding]; other site 218494002701 nucleotide binding site [chemical binding]; other site 218494002702 homodimer interface [polypeptide binding]; other site 218494002703 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 9.2e-96 218494002704 Na+/H+ antiporter family; Region: Na_H_antiporter; cl15356 218494002705 HMMPfam hit to PF03606, C4-dicarboxylate anaerobic carrier, score 9.7e-204 218494002706 13 probable transmembrane helices predicted for SSU0584 by TMHMM2.0 at aa 13-35, 75-97, 121-138, 148-170, 177-196, 200-222, 264-282, 297-319, 321-338, 348-370, 391-413, 446-468 and 475-497 218494002707 hypothetical protein; Provisional; Region: PRK07205 218494002708 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 218494002709 active site 218494002710 metal binding site [ion binding]; metal-binding site 218494002711 HMMPfam hit to PF01546, Peptidase M20, score 3.5e-27 218494002712 Predicted helix-turn-helix motif with score 1124.000, SD 3.02 at aa 430-451, sequence MPLEDLYKTMDIYAEAVYRLTA 218494002713 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 218494002714 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 218494002715 active site 218494002716 catalytic residues [active] 218494002717 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 218494002718 active site 218494002719 HMMPfam hit to PF00754, Coagulation factor 5/8 type, C-terminal, score 0.0029 218494002720 HMMPfam hit to PF00754, Coagulation factor 5/8 type, C-terminal, score 4.3e-06 218494002721 HMMPfam hit to PF00722, Glycoside hydrolase, family 16, score 1.7e-33 218494002722 PS00017 ATP/GTP-binding site motif A (P-loop). 218494002723 HMMPfam hit to PF00728, Glycoside hydrolase, family 20, catalytic core, score 7.8e-15 218494002724 PS00017 ATP/GTP-binding site motif A (P-loop). 218494002725 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 0.0002 218494002726 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494002727 Arginine repressor [Transcription]; Region: ArgR; COG1438 218494002728 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 218494002729 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 218494002730 HMMPfam hit to PF02863, Arginine repressor, score 8.9e-27 218494002731 HMMPfam hit to PF01316, Arginine repressor, score 1.2e-18 218494002732 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 218494002733 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 218494002734 HMMPfam hit to PF02547, Queuosine biosynthesis protein, score 1.8e-118 218494002735 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 218494002736 active site 218494002737 trimer interface [polypeptide binding]; other site 218494002738 allosteric site; other site 218494002739 active site lid [active] 218494002740 hexamer (dimer of trimers) interface [polypeptide binding]; other site 218494002741 HMMPfam hit to PF01182, Glucosamine/galactosamine-6-phosphate isomerase, score 1.8e-41 218494002742 1 probable transmembrane helix predicted for SSU0592 by TMHMM2.0 at aa 12-31 218494002743 1 probable transmembrane helix predicted for SSU0593 by TMHMM2.0 at aa 12-34 218494002744 1 probable transmembrane helix predicted for SSU0594 by TMHMM2.0 at aa 12-34 218494002745 1 probable transmembrane helix predicted for SSU0595 by TMHMM2.0 at aa 7-29 218494002746 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 218494002747 D-alanine--poly(phosphoribitol) ligase, subunit 1; Region: D-ala-DACP-lig; TIGR01734 218494002748 HMMPfam hit to PF00501, AMP-dependent synthetase and ligase, score 2.7e-113 218494002749 PS00455 AMP-binding domain signature. 218494002750 PS00697 ATP-dependent DNA ligase AMP-binding site. 218494002751 MBOAT family; Region: MBOAT; cl00738 218494002752 8 probable transmembrane helices predicted for SSU0597 by TMHMM2.0 at aa 13-35, 50-72, 91-108, 113-135, 194-216, 236-258, 322-344 and 385-407 218494002753 HMMPfam hit to PF03062, Membrane bound O-acyl transferase, MBOAT, score 7.3e-92 218494002754 Phosphopantetheine attachment site; Region: PP-binding; cl09936 218494002755 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 218494002756 DltD N-terminal region; Region: DltD_N; pfam04915 218494002757 DltD central region; Region: DltD_M; pfam04918 218494002758 DltD C-terminal region; Region: DltD_C; pfam04914 218494002759 1 probable transmembrane helix predicted for SSU0599 by TMHMM2.0 at aa 5-27 218494002760 HMMPfam hit to PF04915, DltD, N-terminal, score 2.3e-31 218494002761 HMMPfam hit to PF04918, DltD, central region, score 5.8e-60 218494002762 HMMPfam hit to PF04914, DltD, C-terminal, score 1.1e-74 218494002763 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 218494002764 12 probable transmembrane helices predicted for SSU0600 by TMHMM2.0 at aa 12-31, 41-63, 70-88, 98-120, 132-151, 161-175, 195-217, 222-241, 253-272, 282-304, 316-333 and 338-357 218494002765 HMMPfam hit to PF06772, Bacterial low temperature requirement A, score 8.7e-51 218494002766 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 218494002767 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 218494002768 putative dimer interface [polypeptide binding]; other site 218494002769 N-terminal domain interface [polypeptide binding]; other site 218494002770 putative substrate binding pocket (H-site) [chemical binding]; other site 218494002771 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal, score 1.1e-10 218494002772 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 218494002773 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218494002774 RNA binding surface [nucleotide binding]; other site 218494002775 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 218494002776 active site 218494002777 uracil binding [chemical binding]; other site 218494002778 HMMPfam hit to PF01479, RNA-binding S4, score 2.8e-05 218494002779 HMMPfam hit to PF00849, Pseudouridine synthase, score 2.2e-10 218494002780 PS01149 Rsu family of pseudouridine synthase signature. 218494002781 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 218494002782 catalytic residues [active] 218494002783 dimer interface [polypeptide binding]; other site 218494002784 HMMPfam hit to PF00255, Glutathione peroxidase, score 4.6e-46 218494002785 PS00763 Glutathione peroxidases signature 2. 218494002786 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218494002787 ABC-ATPase subunit interface; other site 218494002788 dimer interface [polypeptide binding]; other site 218494002789 putative PBP binding regions; other site 218494002790 HMMPfam hit to PF01032, Bacterial ABC transporter permease, score 2.2e-85 218494002791 9 probable transmembrane helices predicted for SSU0604 by TMHMM2.0 at aa 7-29, 57-79, 86-108, 118-140, 152-174, 197-214, 244-266, 281-298 and 305-327 218494002792 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 218494002793 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218494002794 ABC-ATPase subunit interface; other site 218494002795 dimer interface [polypeptide binding]; other site 218494002796 putative PBP binding regions; other site 218494002797 HMMPfam hit to PF01032, Bacterial ABC transporter permease, score 5.2e-102 218494002798 9 probable transmembrane helices predicted for SSU0605 by TMHMM2.0 at aa 17-39, 68-90, 103-125, 129-151, 158-180, 200-222, 243-274, 289-311 and 318-335 218494002799 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 218494002800 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 218494002801 putative ligand binding residues [chemical binding]; other site 218494002802 HMMPfam hit to PF01497, Periplasmic binding protein, score 4e-45 218494002803 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494002804 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 218494002805 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 218494002806 Walker A/P-loop; other site 218494002807 ATP binding site [chemical binding]; other site 218494002808 Q-loop/lid; other site 218494002809 ABC transporter signature motif; other site 218494002810 Walker B; other site 218494002811 D-loop; other site 218494002812 H-loop/switch region; other site 218494002813 HMMPfam hit to PF00005, ABC transporter related, score 1.1e-50 218494002814 PS00211 ABC transporters family signature. 218494002815 PS00017 ATP/GTP-binding site motif A (P-loop). 218494002816 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 218494002817 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 218494002818 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218494002819 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218494002820 HMMPfam hit to PF02875, Mur ligase, C-terminal, score 3.2e-21 218494002821 HMMPfam hit to PF08245, Mur ligase, central, score 3.5e-32 218494002822 HMMPfam hit to PF01225, Mur ligase, N-terminal, score 0.0039 218494002823 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 218494002824 putative acyl-acceptor binding pocket; other site 218494002825 HMMPfam hit to PF01553, Phospholipid/glycerol acyltransferase, score 4.3e-25 218494002826 1 probable transmembrane helix predicted for SSU0609 by TMHMM2.0 at aa 217-239 218494002827 SLBB domain; Region: SLBB; pfam10531 218494002828 comEA protein; Region: comE; TIGR01259 218494002829 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 218494002830 1 probable transmembrane helix predicted for SSU0610 by TMHMM2.0 at aa 16-38 218494002831 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 5.7e-07 218494002832 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 218494002833 Competence protein; Region: Competence; cl00471 218494002834 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 218494002835 8 probable transmembrane helices predicted for SSU0611 by TMHMM2.0 at aa 23-45, 230-251, 271-290, 311-333, 353-375, 382-404, 435-457 and 464-483 218494002836 HMMPfam hit to PF03772, ComEC/Rec2-related protein, score 4.6e-43 218494002837 HMMPfam hit to PF00753, Beta-lactamase-like, score 1.1e-10 218494002838 Probable gene remnant. Similar to an internal region of Streptococcus criceti transposase UniProt:Q93RH3 (EMBL:AB042239) (287 aa) fasta scores: E()=1.4e-08, 66.667% id in 42 aa 218494002839 FOG: CBS domain [General function prediction only]; Region: COG0517 218494002840 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 218494002841 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 2.1e-40 218494002842 HMMPfam hit to PF01842, Amino acid-binding ACT, score 0.0071 218494002843 1 probable transmembrane helix predicted for SSU0614 by TMHMM2.0 at aa 16-38 218494002844 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 218494002845 PS00221 MIP family signature. 218494002846 Uncharacterized conserved protein [Function unknown]; Region: COG1284 218494002847 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 218494002848 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 218494002849 HMMPfam hit to PF02588, Protein of unknown function DUF161, score 4.3e-22 218494002850 5 probable transmembrane helices predicted for SSU0616 by TMHMM2.0 at aa 7-25, 40-62, 74-91, 104-123 and 144-166 218494002851 HMMPfam hit to PF02588, Protein of unknown function DUF161, score 1.3e-23 218494002852 thymidylate kinase; Validated; Region: tmk; PRK00698 218494002853 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 218494002854 TMP-binding site; other site 218494002855 ATP-binding site [chemical binding]; other site 218494002856 HMMPfam hit to PF02223, Thymidylate kinase, score 3.6e-64 218494002857 PS00017 ATP/GTP-binding site motif A (P-loop). 218494002858 PS01331 Thymidylate kinase signature. 218494002859 DNA polymerase III subunit delta'; Validated; Region: PRK07276 218494002860 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494002861 Protein of unknown function (DUF972); Region: DUF972; cl01853 218494002862 HMMPfam hit to PF06156, Protein of unknown function DUF972, score 1.9e-53 218494002863 Predicted methyltransferases [General function prediction only]; Region: COG0313 218494002864 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 218494002865 HMMPfam hit to PF00590, Tetrapyrrole methylase, score 5.6e-43 218494002866 PS01296 Uncharacterized protein family UPF0011 signature. 218494002867 Aminotransferase class-V; Region: Aminotran_5; pfam00266 218494002868 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 218494002869 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218494002870 catalytic residue [active] 218494002871 HMMPfam hit to PF00266, Aminotransferase, class V, score 2.1e-21 218494002872 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 0.0016 218494002873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494002874 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 218494002875 L-serine binding site [chemical binding]; other site 218494002876 ACT domain interface; other site 218494002877 HMMPfam hit to PF00389, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region, score 9e-18 218494002878 HMMPfam hit to PF02826, D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding, score 4.6e-49 218494002879 PS00017 ATP/GTP-binding site motif A (P-loop). 218494002880 PS00065 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. 218494002881 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 218494002882 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 218494002883 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 218494002884 DNA binding site [nucleotide binding] 218494002885 active site 218494002886 HMMPfam hit to PF01035, Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding, score 6.6e-35 218494002887 PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. 218494002888 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 218494002889 ArsC family; Region: ArsC; pfam03960 218494002890 putative ArsC-like catalytic residues; other site 218494002891 putative TRX-like catalytic residues [active] 218494002892 HMMPfam hit to PF03960, Arsenate reductase and related, score 3.8e-31 218494002893 Cation efflux family; Region: Cation_efflux; cl00316 218494002894 HMMPfam hit to PF01545, Cation efflux protein, score 1.3e-05 218494002895 6 probable transmembrane helices predicted for SSU0626 by TMHMM2.0 at aa 13-32, 36-58, 88-110, 115-137, 158-180 and 193-215 218494002896 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 218494002897 active site 218494002898 DNA binding site [nucleotide binding] 218494002899 putative phosphate binding site [ion binding]; other site 218494002900 putative catalytic site [active] 218494002901 metal binding site A [ion binding]; metal-binding site 218494002902 AP binding site [nucleotide binding]; other site 218494002903 metal binding site B [ion binding]; metal-binding site 218494002904 HMMPfam hit to PF03372, Endonuclease/exonuclease/phosphatase, score 3.6e-45 218494002905 PS00728 AP endonucleases family 1 signature 3. 218494002906 PS00727 AP endonucleases family 1 signature 2. 218494002907 PS00726 AP endonucleases family 1 signature 1. 218494002908 3 probable transmembrane helices predicted for SSU0628 by TMHMM2.0 at aa 5-27, 37-59 and 84-106 218494002909 Amino acid permease; Region: AA_permease; cl00524 218494002910 12 probable transmembrane helices predicted for SSU0629 by TMHMM2.0 at aa 21-43, 53-75, 88-110, 146-168, 180-199, 214-236, 257-279, 303-325, 357-379, 383-400, 413-432 and 437-456 218494002911 HMMPfam hit to PF00324, Amino acid permease-associated region, score 9.8e-24 218494002912 CDS contains a nonsense mutation (amber) after codon 230. Similar to Streptococcus pyogenes (serotype M3) hypothetical protein sps0152. UniProt:Q879N6 (EMBL:BA000034) (302 aa) fasta scores: E()=8.7e-13, 28.622% id in 283 aa, and to Streptococcus pyogenes (serotype M3) hypothetical protein spym3_0148. UniProt:Q8K8R2 (EMBL:AE014139) (287 aa) fasta scores: E()=8.4e-13, 29.032% id in 279 aa 218494002913 HMMPfam hit to PF06161, Protein of unknown function DUF975, score 7e-06 218494002914 4 probable transmembrane helices predicted for SSU0630 by TMHMM2.0 at aa 29-51, 84-106, 142-164 and 184-206 218494002915 HMMPfam hit to PF06161, Protein of unknown function DUF975, score 1.1e-15 218494002916 1 probable transmembrane helix predicted for SSU0631 by TMHMM2.0 at aa 15-37 218494002917 HMMPfam hit to PF06161, Protein of unknown function DUF975, score 2.4e-10 218494002918 Protein of unknown function (DUF975); Region: DUF975; cl10504 218494002919 5 probable transmembrane helices predicted for SSU0632 by TMHMM2.0 at aa 20-42, 69-91, 122-144, 178-200 and 237-259 218494002920 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 218494002921 8 probable transmembrane helices predicted for SSU0633 by TMHMM2.0 at aa 21-43, 53-75, 95-117, 121-143, 164-183, 198-220, 227-249 and 259-280 218494002922 HMMPfam hit to PF02517, Abortive infection protein, score 1.2e-07 218494002923 Probable gene remnant. CDS lacks a translation start codon. Similar to the C-terminal regions of Salmonella typhimurium type III restriction-modification system enzyme Mod UniProt:P40814 (EMBL:STRESM) (652 aa) fasta scores: E()=1.4e-41, 41.648% id in 437 aa, and Bacteroides fragilis (strain ATCC 25285/NCTC 9343) modification enzyme of type III restriction-modification system UniProt:Q5LG95 (EMBL:CR626927) (635 aa) fasta scores: E()=3.4e-116, 54.880% id in 543 aa 218494002924 HMMPfam hit to PF01555, DNA methylase N-4/N-6, score 1.5e-13 218494002925 PS00092 N-6 Adenine-specific DNA methylases signature. 218494002926 HMMPfam hit to PF01555, DNA methylase N-4/N-6, score 2.4e-32 218494002927 Restriction endonuclease [Defense mechanisms]; Region: COG3587 218494002928 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218494002929 ATP binding site [chemical binding]; other site 218494002930 HMMPfam hit to PF04851, Restriction endonuclease, type I, R subunit/Type III, Res subunit, score 8.7e-07 218494002931 CDS contains frameshifts after codons 15 and 129. Second frameshift appear to be the result of an DNA insertion. Similar to Photorhabdus luminescens (subsp. laumondii) ISPlu5a transposase, IS200 family UniProt:Q7MYQ8 (EMBL:BX571874) (151 aa) fasta scores: E()=5.4e-45, 76.000% id in 150 aa 218494002932 HMMPfam hit to PF01797, Transposase IS200-like, score 2e-58 218494002933 extra DNA 218494002934 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 218494002935 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 218494002936 active site 218494002937 substrate binding site [chemical binding]; other site 218494002938 metal binding site [ion binding]; metal-binding site 218494002939 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase C-terminal, score 1.7e-05 218494002940 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III, score 2.1e-08 218494002941 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II, score 0.0039 218494002942 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I, score 5.6e-60 218494002943 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 218494002944 Predicted membrane protein [Function unknown]; Region: COG4684 218494002945 6 probable transmembrane helices predicted for SSU0645 by TMHMM2.0 at aa 13-35, 40-54, 61-83, 93-115, 122-144 and 159-181 218494002946 Flavoprotein; Region: Flavoprotein; cl08021 218494002947 HMMPfam hit to PF02441, Flavoprotein, score 1.1e-42 218494002948 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 218494002949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494002950 HMMPfam hit to PF04127, DNA/pantothenate metabolism flavoprotein, C-terminal, score 1.2e-61 218494002951 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 218494002952 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 218494002953 Potassium binding sites [ion binding]; other site 218494002954 Cesium cation binding sites [ion binding]; other site 218494002955 HMMPfam hit to PF01268, Formate-tetrahydrofolate ligase, FTHFS, score 0 218494002956 PS00721 Formate--tetrahydrofolate ligase signature 1. 218494002957 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 218494002958 7 probable transmembrane helices predicted for SSU0649 by TMHMM2.0 at aa 13-32, 42-64, 77-99, 119-141, 150-172, 192-211 and 223-245 218494002959 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 218494002960 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494002961 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494002962 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 218494002963 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 9.6e-45 218494002964 PS00017 ATP/GTP-binding site motif A (P-loop). 218494002965 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 218494002966 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 8.1e-28 218494002967 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidoreductase dimerisation region, score 3.7e-32 218494002968 genomic island 218494002969 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 218494002970 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 218494002971 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218494002972 ATP binding site [chemical binding]; other site 218494002973 putative Mg++ binding site [ion binding]; other site 218494002974 HMMPfam hit to PF04313, Restriction endonuclease, type I, EcoRI, R subunit/Type III, Res subunit, N terminus, score 5.7e-20 218494002975 HMMPfam hit to PF04851, Restriction endonuclease, type I, R subunit/Type III, Res subunit, score 2e-19 218494002976 PS00017 ATP/GTP-binding site motif A (P-loop). 218494002977 CDS contains a frameshift after codon 326. Frameshift occurs at a poly T pentamer. Similar to Escherichia coli hsdm type I restriction enzyme EcoPRRI M protein UniProt:Q47163 (EMBL:ECDNAHSDM) (520 aa) fasta scores: E()=3e-07, 27.290% id in 535 aa 218494002978 HMMPfam hit to PF02384, N-6 DNA methylase, score 6.1e-33 218494002979 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 218494002980 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 218494002981 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 218494002982 HMMPfam hit to PF01420, Restriction endonuclease, type I, S subunit, EcoBI, score 2.5e-08 218494002983 PS00017 ATP/GTP-binding site motif A (P-loop). 218494002984 HMMPfam hit to PF01420, Restriction endonuclease, type I, S subunit, EcoBI, score 9.9e-09 218494002985 1 probable transmembrane helix predicted for SSU0653 by TMHMM2.0 at aa 314-336 218494002986 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494002987 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 218494002988 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.1e-18 218494002989 CDS contains a nonsense mutation (opal) after codon 103. Similar to Streptococcus agalactiae (serotype V) hypothetical protein SAG1132 UniProt:Q8DZG9 (EMBL:AE014243) (219 aa) fasta scores: E()=1.5e-31, 42.254% id in 213 aa 218494002990 HMMPfam hit to PF08713, DNA alkylation repair enzyme, score 3.1e-06 218494002991 HMMPfam hit to PF08713, DNA alkylation repair enzyme, score 7.9e-10 218494002992 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 218494002993 HMMPfam hit to PF08922, Protein of unknown function DUF1905, score 6.4e-41 218494002994 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 218494002995 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15367 218494002996 FeS/SAM binding site; other site 218494002997 HMMPfam hit to PF04055, Radical SAM, score 2.3e-19 218494002998 PS01087 Radical activating enzymes signature. 218494002999 PS00473 Gonadotropin-releasing hormones signature. 218494003000 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 218494003001 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218494003002 DNA-binding site [nucleotide binding]; DNA binding site 218494003003 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 218494003004 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 1.8e-20 218494003005 PS00894 Bacterial regulatory proteins, deoR family signature. 218494003006 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 1.1e-45 218494003007 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 218494003008 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494003009 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 218494003010 Predicted helix-turn-helix motif with score 1571.000, SD 4.54 at aa 21-42, sequence KSQAEIAADTGIYRTTVSRMLT 218494003011 HMMPfam hit to PF04198, sugar-binding region, score 4.1e-80 218494003012 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 218494003013 active site 218494003014 methionine cluster; other site 218494003015 phosphorylation site [posttranslational modification] 218494003016 metal binding site [ion binding]; metal-binding site 218494003017 HMMPfam hit to PF02255, Phosphotransferase system, lactose/cellobiose-specific IIA subunit, score 3.4e-35 218494003018 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 218494003019 active site 218494003020 P-loop; other site 218494003021 phosphorylation site [posttranslational modification] 218494003022 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 2.4e-37 218494003023 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 218494003024 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 218494003025 10 probable transmembrane helices predicted for SSU0666 by TMHMM2.0 at aa 21-43, 71-93, 100-122, 137-159, 179-198, 223-245, 250-272, 292-311, 349-371 and 395-417 218494003026 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 6.1e-109 218494003027 pyruvate formate-lyase; Region: PFL2-3; TIGR01774 218494003028 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 218494003029 dimer interface [polypeptide binding]; other site 218494003030 active site 218494003031 glycine loop; other site 218494003032 HMMPfam hit to PF02901, Pyruvate formate-lyase, PFL, score 1.3e-165 218494003033 HMMPfam hit to PF01228, Formate C-acetyltransferase glycine radical, score 4.5e-24 218494003034 PS00850 Glycine radical signature. 218494003035 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 218494003036 active site 218494003037 intersubunit interactions; other site 218494003038 catalytic residue [active] 218494003039 HMMPfam hit to PF00923, Transaldolase, score 6.3e-27 218494003040 PS00958 Transaldolase active site. 218494003041 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 218494003042 active site 218494003043 NAD binding site [chemical binding]; other site 218494003044 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 218494003045 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 218494003046 dimer interface [polypeptide binding]; other site 218494003047 active site 218494003048 metal binding site [ion binding]; metal-binding site 218494003049 HMMPfam hit to PF00465, Iron-containing alcohol dehydrogenase, score 9.6e-85 218494003050 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 218494003051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494003052 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 218494003053 HMMPfam hit to PF01118, Semialdehyde dehydrogenase, NAD - binding, score 2.9e-49 218494003054 HMMPfam hit to PF02774, Semialdehyde dehydrogenase, dimerisation region, score 2.5e-77 218494003055 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 218494003056 dihydrodipicolinate synthase; Region: dapA; TIGR00674 218494003057 dimer interface [polypeptide binding]; other site 218494003058 active site 218494003059 catalytic residue [active] 218494003060 HMMPfam hit to PF00701, Dihydrodipicolinate synthetase, score 5.4e-95 218494003061 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 218494003062 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494003063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494003064 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 218494003065 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 5.7e-08 218494003066 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 2.5e-15 218494003067 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 6.8e-06 218494003068 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 218494003069 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494003070 HMMPfam hit to PF05043, M trans-acting positive regulator, score 9.4e-23 218494003071 Predicted helix-turn-helix motif with score 1807.000, SD 5.34 at aa 107-128, sequence VSIQQLAQELLISEATLNRHLA 218494003072 glycerol kinase; Provisional; Region: glpK; PRK00047 218494003073 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 218494003074 N- and C-terminal domain interface [polypeptide binding]; other site 218494003075 active site 218494003076 MgATP binding site [chemical binding]; other site 218494003077 catalytic site [active] 218494003078 metal binding site [ion binding]; metal-binding site 218494003079 glycerol binding site [chemical binding]; other site 218494003080 homotetramer interface [polypeptide binding]; other site 218494003081 homodimer interface [polypeptide binding]; other site 218494003082 FBP binding site [chemical binding]; other site 218494003083 protein IIAGlc interface [polypeptide binding]; other site 218494003084 HMMPfam hit to PF00370, Carbohydrate kinase, FGGY, score 1.2e-115 218494003085 PS00933 FGGY family of carbohydrate kinases signature 1. 218494003086 HMMPfam hit to PF02782, Carbohydrate kinase, FGGY, score 1.3e-76 218494003087 PS00445 FGGY family of carbohydrate kinases signature 2. 218494003088 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 218494003089 1 probable transmembrane helix predicted for SSU0676 by TMHMM2.0 at aa 20-42 218494003090 HMMPfam hit to PF01266, FAD dependent oxidoreductase, score 6.1e-65 218494003091 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 218494003092 amphipathic channel; other site 218494003093 Asn-Pro-Ala signature motifs; other site 218494003094 HMMPfam hit to PF00230, Major intrinsic protein, score 3.5e-28 218494003095 6 probable transmembrane helices predicted for SSU0677 by TMHMM2.0 at aa 7-29, 39-61, 81-103, 132-154, 161-183 and 213-235 218494003096 PS00221 MIP family signature. 218494003097 PS00079 Multicopper oxidases signature 1. 218494003098 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 218494003099 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 218494003100 Zn binding site [ion binding]; other site 218494003101 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 218494003102 Zn binding site [ion binding]; other site 218494003103 HMMPfam hit to PF00903, Glyoxalase/bleomycin resistance protein/dioxygenase, score 9e-10 218494003104 CDS contains a nonsense mutation (ochre) after codon 31. Similar to Enterococcus faecalis (Streptococcus faecalis) hypothetical protein UniProt:Q838A5 (EMBL:AE016948) (190 aa) fasta scores: E()=4e-21, 40.526% id in 190 aa 218494003105 oligoendopeptidase F; Region: pepF; TIGR00181 218494003106 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 218494003107 active site 218494003108 Zn binding site [ion binding]; other site 218494003109 HMMPfam hit to PF01432, Peptidase M3A and M3B, thimet/oligopeptidase F, score 2.4e-22 218494003110 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218494003111 HMMPfam hit to PF08439, Peptidase M3B, oligopeptidase F, N-terminal, score 5.3e-16 218494003112 ATP cone domain; Region: ATP-cone; pfam03477 218494003113 HMMPfam hit to PF03477, ATP-cone, score 6.4e-28 218494003114 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 218494003115 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494003116 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 218494003117 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 2.4e-44 218494003118 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 2.3e-33 218494003119 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidoreductase dimerisation region, score 6.6e-08 218494003120 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 218494003121 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494003122 HMMPfam hit to PF00580, DNA helicase, UvrD/REP type, score 2.3e-207 218494003123 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003124 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 218494003125 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218494003126 motif II; other site 218494003127 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 5.7e-15 218494003128 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 218494003129 dimer interface [polypeptide binding]; other site 218494003130 substrate binding site [chemical binding]; other site 218494003131 ATP binding site [chemical binding]; other site 218494003132 HMMPfam hit to PF08543, Phosphomethylpyrimidine kinase type-1, score 1.1e-138 218494003133 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 218494003134 substrate binding site [chemical binding]; other site 218494003135 multimerization interface [polypeptide binding]; other site 218494003136 ATP binding site [chemical binding]; other site 218494003137 HMMPfam hit to PF02110, Hydroxyethylthiazole kinase, score 4.3e-84 218494003138 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 218494003139 thiamine phosphate binding site [chemical binding]; other site 218494003140 active site 218494003141 pyrophosphate binding site [ion binding]; other site 218494003142 HMMPfam hit to PF02581, Thiamine monophosphate synthase, score 1.1e-93 218494003143 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 218494003144 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 218494003145 ligand binding site [chemical binding]; other site 218494003146 flexible hinge region; other site 218494003147 HMMPfam hit to PF00027, Cyclic nucleotide-binding, score 1.2e-16 218494003148 Predicted helix-turn-helix motif with score 1203.000, SD 3.28 at aa 175-196, sequence FNSERLSQEMAVTQRSINRLLK 218494003149 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 218494003150 HMMPfam hit to PF01048, Nucleoside phosphorylase, score 1.1e-34 218494003151 PS01232 Purine and other phosphorylases family 1 signature. 218494003152 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 218494003153 4 probable transmembrane helices predicted for SSU0690 by TMHMM2.0 at aa 15-37, 42-64, 79-101 and 108-130 218494003154 Cobalt transport protein; Region: CbiQ; cl00463 218494003155 HMMPfam hit to PF02361, Cobalt transport protein, score 6.5e-14 218494003156 4 probable transmembrane helices predicted for SSU0691 by TMHMM2.0 at aa 20-51, 58-80, 100-122 and 233-250 218494003157 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 218494003158 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 218494003159 Walker A/P-loop; other site 218494003160 ATP binding site [chemical binding]; other site 218494003161 Q-loop/lid; other site 218494003162 ABC transporter signature motif; other site 218494003163 Walker B; other site 218494003164 D-loop; other site 218494003165 H-loop/switch region; other site 218494003166 HMMPfam hit to PF00005, ABC transporter related, score 4.3e-51 218494003167 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003168 PS00211 ABC transporters family signature. 218494003169 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 218494003170 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 218494003171 Walker A/P-loop; other site 218494003172 ATP binding site [chemical binding]; other site 218494003173 Q-loop/lid; other site 218494003174 ABC transporter signature motif; other site 218494003175 Walker B; other site 218494003176 D-loop; other site 218494003177 H-loop/switch region; other site 218494003178 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 218494003179 HMMPfam hit to PF00005, ABC transporter related, score 9e-34 218494003180 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003181 Predicted helix-turn-helix motif with score 1145.000, SD 3.09 at aa 224-245, sequence FSQKDVLEKAYLSQPTTMQLCQ 218494003182 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 218494003183 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218494003184 motif II; other site 218494003185 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 5.1e-19 218494003186 6 probable transmembrane helices predicted for SSU0695 by TMHMM2.0 at aa 22-44, 64-86, 99-121, 156-178, 199-221 and 231-253 218494003187 HMMPfam hit to PF02517, Abortive infection protein, score 0.0036 218494003188 Bacteriophage holin; Region: Phage_holin_1; cl02344 218494003189 2 probable transmembrane helices predicted for SSU0696 by TMHMM2.0 at aa 23-45 and 55-74 218494003190 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 218494003191 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494003192 HMMPfam hit to PF02557, Peptidase M15B and M15C, D,D-carboxypeptidase VanY/endolysins, score 3.5e-48 218494003193 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 218494003194 dimer interface [polypeptide binding]; other site 218494003195 HMMPfam hit to PF00903, Glyoxalase/bleomycin resistance protein/dioxygenase, score 0.00047 218494003196 13 probable transmembrane helices predicted for SSU0700 by TMHMM2.0 at aa 43-65, 75-97, 122-144, 159-181, 188-210, 220-239, 246-265, 316-338, 351-373, 402-424, 429-451, 477-499 and 506-528 218494003197 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 218494003198 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 218494003199 Walker A/P-loop; other site 218494003200 ATP binding site [chemical binding]; other site 218494003201 Q-loop/lid; other site 218494003202 ABC transporter signature motif; other site 218494003203 Walker B; other site 218494003204 D-loop; other site 218494003205 H-loop/switch region; other site 218494003206 HMMPfam hit to PF00005, ABC transporter related, score 6.1e-42 218494003207 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218494003208 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003209 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 218494003210 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 218494003211 GIY-YIG motif/motif A; other site 218494003212 active site 218494003213 catalytic site [active] 218494003214 putative DNA binding site [nucleotide binding]; other site 218494003215 metal binding site [ion binding]; metal-binding site 218494003216 UvrB/uvrC motif; Region: UVR; pfam02151 218494003217 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 218494003218 HMMPfam hit to PF01541, Excinuclease ABC, C subunit, N-terminal, score 2e-33 218494003219 HMMPfam hit to PF02151, UvrB/UvrC protein, score 8.9e-11 218494003220 HMMPfam hit to PF08459, Excinuclease ABC, C subunit, C-terminal, score 6.2e-92 218494003221 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 218494003222 1 probable transmembrane helix predicted for SSU0703 by TMHMM2.0 at aa 19-41 218494003223 GTPase CgtA; Reviewed; Region: obgE; PRK12297 218494003224 GTP1/OBG; Region: GTP1_OBG; pfam01018 218494003225 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 218494003226 G1 box; other site 218494003227 GTP/Mg2+ binding site [chemical binding]; other site 218494003228 Switch I region; other site 218494003229 G2 box; other site 218494003230 G3 box; other site 218494003231 Switch II region; other site 218494003232 G4 box; other site 218494003233 G5 box; other site 218494003234 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 218494003235 HMMPfam hit to PF01018, GTP1/OBG subdomain, score 1.6e-79 218494003236 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 3.4e-41 218494003237 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003238 PS00905 GTP1/OBG family signature. 218494003239 HMMPfam hit to PF09269, GTP1/OBG, C-terminal, score 1.6e-37 218494003240 Gram positive anchor; Region: Gram_pos_anchor; cl15427 218494003241 HMMPfam hit to PF04650, YSIRK Gram-positive signal peptide, score 2.8e-09 218494003242 1 probable transmembrane helix predicted for SSU0706 by TMHMM2.0 at aa 23-45 218494003243 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003244 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003245 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003246 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 6.2e-09 218494003247 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494003248 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 218494003249 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl15476 218494003250 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 218494003251 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 218494003252 PS00515 Seminal vesicle protein II repeats signature. 218494003253 helicase-exonuclease AddAB, AddA subunit; Region: addA_Gpos; TIGR02785 218494003254 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494003255 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494003256 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 218494003257 HMMPfam hit to PF00580, DNA helicase, UvrD/REP type, score 4.5e-81 218494003258 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003259 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218494003260 Domain of unknown function (DUF205); Region: DUF205; cl00410 218494003261 HMMPfam hit to PF02660, Protein of unknown function DUF205, score 6.5e-56 218494003262 6 probable transmembrane helices predicted for SSU0709 by TMHMM2.0 at aa 2-24, 53-75, 80-98, 113-135, 142-164 and 169-186 218494003263 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 218494003264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218494003265 Mg2+ binding site [ion binding]; other site 218494003266 G-X-G motif; other site 218494003267 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 218494003268 anchoring element; other site 218494003269 dimer interface [polypeptide binding]; other site 218494003270 ATP binding site [chemical binding]; other site 218494003271 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 218494003272 active site 218494003273 putative metal-binding site [ion binding]; other site 218494003274 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 218494003275 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.1e-31 218494003276 HMMPfam hit to PF00204, DNA topoisomerase, type IIA, subunit B, region 2, score 1.2e-89 218494003277 HMMPfam hit to PF01751, TOPRIM, score 1e-05 218494003278 PS00177 DNA topoisomerase II signature. 218494003279 HMMPfam hit to PF00986, DNA topoisomerase, type IIA, subunit B, C-terminal, score 1.2e-45 218494003280 Probable gene remnant. Similar to the C-terminal region of Streptococcus pneumoniae topoisomerase IV subunit B ParE UniProt:Q59961 (EMBL:AE007391) (647 aa) fasta scores: E()=7.2e-08, 84.375% id in 32 aa 218494003281 CDS contains a frameshift after codon 71. Similar to Lactococcus lactis subsp. cremoris (Streptococcus cremoris) MobC mobilization protein UniProt:O54679 (EMBL:AF036485) (200 aa) fasta scores: E()=4.1e-51, 68.500% id in 200 aa 218494003282 HMMPfam hit to PF02661, Filamentation induced by cAMP protein Fic, score 2.5e-09 218494003283 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 218494003284 HMMPfam hit to PF06803, Protein of unknown function DUF1232, score 2.5e-16 218494003285 1 probable transmembrane helix predicted for SSU0715 by TMHMM2.0 at aa 103-125 218494003286 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 218494003287 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 218494003288 CAP-like domain; other site 218494003289 active site 218494003290 primary dimer interface [polypeptide binding]; other site 218494003291 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218494003292 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218494003293 HMMPfam hit to PF00521, DNA topoisomerase, type IIA, subunit A or C-terminal, score 5.8e-285 218494003294 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 0.052 218494003295 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 1.9e-05 218494003296 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 2.2e-12 218494003297 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 0.00017 218494003298 1 probable transmembrane helix predicted for SSU0718 by TMHMM2.0 at aa 12-34 218494003299 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 218494003300 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 218494003301 homodimer interface [polypeptide binding]; other site 218494003302 substrate-cofactor binding pocket; other site 218494003303 catalytic residue [active] 218494003304 HMMPfam hit to PF01063, Aminotransferase, class IV, score 1.3e-120 218494003305 PS00770 Aminotransferases class-IV signature. 218494003306 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 218494003307 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 218494003308 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 218494003309 RNA binding site [nucleotide binding]; other site 218494003310 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 218494003311 RNA binding site [nucleotide binding]; other site 218494003312 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 218494003313 RNA binding site [nucleotide binding]; other site 218494003314 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 218494003315 RNA binding site [nucleotide binding]; other site 218494003316 HMMPfam hit to PF00575, S1, RNA binding, score 4.7e-05 218494003317 HMMPfam hit to PF00575, S1, RNA binding, score 7.3e-15 218494003318 HMMPfam hit to PF00575, S1, RNA binding, score 4.9e-26 218494003319 HMMPfam hit to PF00575, S1, RNA binding, score 1e-27 218494003320 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 218494003321 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 218494003322 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218494003323 catalytic residue [active] 218494003324 HMMPfam hit to PF01212, Aromatic amino acid beta-eliminating lyase/threonine aldolase, score 2e-45 218494003325 3 probable transmembrane helices predicted for SSU0723 by TMHMM2.0 at aa 10-29, 67-86 and 91-110 218494003326 1 probable transmembrane helix predicted for SSU0724 by TMHMM2.0 at aa 20-42 218494003327 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 218494003328 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 218494003329 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218494003330 catalytic residue [active] 218494003331 HMMPfam hit to PF00266, Aminotransferase, class V, score 3.3e-78 218494003332 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 218494003333 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 218494003334 THUMP domain; Region: THUMP; cl12076 218494003335 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 218494003336 Ligand Binding Site [chemical binding]; other site 218494003337 HMMPfam hit to PF02926, THUMP, score 1.7e-16 218494003338 HMMPfam hit to PF02568, Thiamine biosynthesis protein, score 2.8e-93 218494003339 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 218494003340 HMMPfam hit to PF05525, Branched-chain amino acid transport system II carrier protein, score 1.2e-190 218494003341 12 probable transmembrane helices predicted for SSU0727 by TMHMM2.0 at aa 5-27, 37-59, 72-94, 114-136, 143-165, 185-207, 227-249, 281-303, 316-338, 342-364, 377-399 and 409-431 218494003342 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 218494003343 HMMPfam hit to PF00829, Ribosomal protein L21, score 2.2e-54 218494003344 PS01169 Ribosomal protein L21 signature. 218494003345 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 218494003346 HMMPfam hit to PF01016, Ribosomal protein L27, score 4.4e-48 218494003347 PS00831 Ribosomal protein L27 signature. 218494003348 Probable gene remnant. Similar to the C-terminal regions of Streptococcus thermophilus (strain CNRZ 1066) hypothetical protein UniProt:Q5LZJ9 (EMBL:CP000024) (105 aa) fasta scores: E()=2.9e-05, 46.429% id in 56 aa, and to Streptococcus pneumoniae GNAT family acetyltransferase UniProt:Q97S26 (EMBL:AE007369) (294 aa) fasta scores: E()=9.5e-05, 43.860% id in 57 aa 218494003349 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218494003350 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494003351 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 218494003352 dimerization interface [polypeptide binding]; other site 218494003353 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 4.5e-18 218494003354 Predicted helix-turn-helix motif with score 1684.000, SD 4.92 at aa 16-37, sequence GTFREAAEKMYVSQPSLSISIR 218494003355 PS00044 Bacterial regulatory proteins, lysR family signature. 218494003356 HMMPfam hit to PF03466, LysR, substrate-binding, score 2.9e-12 218494003357 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 218494003358 lipoprotein signal peptidase; Provisional; Region: PRK14787 218494003359 HMMPfam hit to PF01252, Peptidase A8, signal peptidase II, score 5.6e-44 218494003360 3 probable transmembrane helices predicted for SSU0731 by TMHMM2.0 at aa 60-79, 86-105 and 120-142 218494003361 PS00855 Signal peptidases II signature. 218494003362 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 218494003363 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218494003364 RNA binding surface [nucleotide binding]; other site 218494003365 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 218494003366 active site 218494003367 HMMPfam hit to PF01479, RNA-binding S4, score 1.4e-08 218494003368 HMMPfam hit to PF00849, Pseudouridine synthase, score 5.1e-75 218494003369 PS01129 Rlu family of pseudouridine synthase signature. 218494003370 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 218494003371 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 218494003372 PhnA protein; Region: PhnA; pfam03831 218494003373 HMMPfam hit to PF08274, PhnA protein, N-terminal, score 1.2e-17 218494003374 HMMPfam hit to PF03831, PhnA protein, C-terminal, score 2.2e-35 218494003375 6 probable transmembrane helices predicted for SSU0734 by TMHMM2.0 at aa 7-29, 33-55, 67-89, 102-119, 131-153 and 173-195 218494003376 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 218494003377 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 5.5e-14 218494003378 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 218494003379 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 218494003380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494003381 HMMPfam hit to PF02729, Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding, score 3e-34 218494003382 PS00097 Aspartate and ornithine carbamoyltransferases signature. 218494003383 HMMPfam hit to PF00185, Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding region, score 3.8e-35 218494003384 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 218494003385 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 218494003386 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 218494003387 catalytic site [active] 218494003388 subunit interface [polypeptide binding]; other site 218494003389 HMMPfam hit to PF00988, Carbamoyl-phosphate synthase, small chain, score 1.8e-87 218494003390 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 2.4e-70 218494003391 PS00442 Glutamine amidotransferases class-I active site. 218494003392 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 218494003393 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 218494003394 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 218494003395 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 218494003396 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 218494003397 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 218494003398 substrate binding site [chemical binding]; other site 218494003399 HMMPfam hit to PF00289, Carbamoyl-phosphate synthetase large chain, N-terminal, score 6.4e-49 218494003400 Predicted helix-turn-helix motif with score 992.000, SD 2.57 at aa 44-65, sequence MTDKEIADKVYIEPITLEFVTR 218494003401 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain, ATP-binding, score 3.2e-143 218494003402 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 218494003403 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 218494003404 HMMPfam hit to PF02787, Carbamoyl-phosphate synthetase large chain, oligomerisation, score 6.5e-65 218494003405 HMMPfam hit to PF00289, Carbamoyl-phosphate synthetase large chain, N-terminal, score 3.1e-27 218494003406 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain, ATP-binding, score 6.9e-36 218494003407 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 218494003408 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 218494003409 HMMPfam hit to PF02142, MGS-like, score 1.6e-25 218494003410 PS00572 Glycosyl hydrolases family 1 active site. 218494003411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 218494003412 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 218494003413 putative substrate binding pocket [chemical binding]; other site 218494003414 AC domain interface; other site 218494003415 catalytic triad [active] 218494003416 AB domain interface; other site 218494003417 interchain disulfide; other site 218494003418 HMMPfam hit to PF01470, Peptidase C15, pyroglutamyl peptidase I, score 1.3e-127 218494003419 PS01333 Pyrrolidone-carboxylate peptidase glutamic acid active site. 218494003420 PS01334 Pyrrolidone-carboxylate peptidase cysteine active site. 218494003421 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 218494003422 HMMPfam hit to PF00886, Ribosomal protein S16, score 3e-28 218494003423 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 218494003424 HMMPfam hit to PF00013, K Homology, type 1, score 2.1e-05 218494003425 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 218494003426 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 218494003427 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494003428 Walker A/P-loop; other site 218494003429 ATP binding site [chemical binding]; other site 218494003430 Q-loop/lid; other site 218494003431 ABC transporter signature motif; other site 218494003432 Walker B; other site 218494003433 D-loop; other site 218494003434 H-loop/switch region; other site 218494003435 6 probable transmembrane helices predicted for SSU0744 by TMHMM2.0 at aa 31-53, 68-90, 145-167, 171-190, 253-275 and 290-312 218494003436 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 2.5e-35 218494003437 HMMPfam hit to PF00005, ABC transporter related, score 4.1e-51 218494003438 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003439 PS00211 ABC transporters family signature. 218494003440 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 218494003441 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 218494003442 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 218494003443 Walker A/P-loop; other site 218494003444 ATP binding site [chemical binding]; other site 218494003445 Q-loop/lid; other site 218494003446 ABC transporter signature motif; other site 218494003447 Walker B; other site 218494003448 D-loop; other site 218494003449 H-loop/switch region; other site 218494003450 3 probable transmembrane helices predicted for SSU0745 by TMHMM2.0 at aa 20-42, 62-84 and 164-186 218494003451 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 2.9e-40 218494003452 HMMPfam hit to PF00005, ABC transporter related, score 6.4e-60 218494003453 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003454 PS00211 ABC transporters family signature. 218494003455 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 218494003456 HMMPfam hit to PF01522, Polysaccharide deacetylase, score 6.4e-33 218494003457 1 probable transmembrane helix predicted for SSU0746 by TMHMM2.0 at aa 17-39 218494003458 homoserine dehydrogenase; Provisional; Region: PRK06349 218494003459 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494003460 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 218494003461 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 218494003462 HMMPfam hit to PF03447, Aspartate/homoserine dehydrogenase, NAD-binding, score 2.4e-34 218494003463 HMMPfam hit to PF00742, Homoserine dehydrogenase, catalytic, score 8.6e-91 218494003464 PS01042 Homoserine dehydrogenase signature. 218494003465 homoserine kinase; Provisional; Region: PRK01212 218494003466 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 218494003467 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 218494003468 HMMPfam hit to PF00288, GHMP kinase, score 4.7e-20 218494003469 PS00627 GHMP kinases ATP-binding domain. 218494003470 HMMPfam hit to PF08544, GHMP kinase, C-terminal, score 3e-07 218494003471 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 218494003472 FAD binding domain; Region: FAD_binding_4; pfam01565 218494003473 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 218494003474 HMMPfam hit to PF01565, FAD linked oxidase, N-terminal, score 2.3e-30 218494003475 HMMPfam hit to PF02873, UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal, score 3.2e-39 218494003476 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 218494003477 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 218494003478 Walker A/P-loop; other site 218494003479 ATP binding site [chemical binding]; other site 218494003480 Q-loop/lid; other site 218494003481 ABC transporter signature motif; other site 218494003482 Walker B; other site 218494003483 D-loop; other site 218494003484 H-loop/switch region; other site 218494003485 TOBE domain; Region: TOBE_2; cl01440 218494003486 HMMPfam hit to PF00005, ABC transporter related, score 2.3e-64 218494003487 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003488 PS00211 ABC transporters family signature. 218494003489 HMMPfam hit to PF08402, Transport-associated OB, type 2, score 9.2e-09 218494003490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494003491 dimer interface [polypeptide binding]; other site 218494003492 conserved gate region; other site 218494003493 putative PBP binding loops; other site 218494003494 ABC-ATPase subunit interface; other site 218494003495 6 probable transmembrane helices predicted for SSU0752 by TMHMM2.0 at aa 7-29, 63-85, 92-114, 141-163, 203-225 and 240-259 218494003496 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 0.003 218494003497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494003498 dimer interface [polypeptide binding]; other site 218494003499 conserved gate region; other site 218494003500 putative PBP binding loops; other site 218494003501 ABC-ATPase subunit interface; other site 218494003502 6 probable transmembrane helices predicted for SSU0753 by TMHMM2.0 at aa 7-29, 62-84, 97-119, 124-146, 174-193 and 228-250 218494003503 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.4e-08 218494003504 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 218494003505 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218494003506 1 probable transmembrane helix predicted for SSU0754 by TMHMM2.0 at aa 5-23 218494003507 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 2.1e-11 218494003508 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 218494003509 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 218494003510 Cl- selectivity filter; other site 218494003511 Cl- binding residues [ion binding]; other site 218494003512 pore gating glutamate residue; other site 218494003513 dimer interface [polypeptide binding]; other site 218494003514 H+/Cl- coupling transport residue; other site 218494003515 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 218494003516 11 probable transmembrane helices predicted for SSU0755 by TMHMM2.0 at aa 17-39, 54-76, 108-127, 157-179, 191-213, 231-253, 266-288, 303-322, 329-351, 366-388 and 401-423 218494003517 HMMPfam hit to PF00654, Chloride channel, core, score 7.7e-48 218494003518 HMMPfam hit to PF02080, TrkA-C, score 1.4e-07 218494003519 Probable gene remnant. Similar to the N-terminal region of Geobacillus kaustophilus transposase UniProt:Q5L2G6 (EMBL:BA000043) (379 aa) fasta scores: E()=5.3e-14, 47.664% id in 107 aa 218494003520 HMMPfam hit to PF01548, Transposase, IS111A/IS1328/IS1533, score 2.1e-06 218494003521 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 218494003522 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 218494003523 putative active site [active] 218494003524 catalytic triad [active] 218494003525 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 218494003526 PA/protease domain interface [polypeptide binding]; other site 218494003527 putative integrin binding motif; other site 218494003528 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 218494003529 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 218494003530 Uncharacterised Sugar-binding Domain; Region: FIVAR; pfam07554 218494003531 HMMPfam hit to PF04650, YSIRK Gram-positive signal peptide, score 1.2e-10 218494003532 1 probable transmembrane helix predicted for SSU0757 by TMHMM2.0 at aa 13-35 218494003533 HMMPfam hit to PF00082, Peptidase S8 and S53, subtilisin, kexin, sedolisin, score 2.1e-39 218494003534 PS00136 Serine proteases, subtilase family, aspartic acid active site. 218494003535 PS00137 Serine proteases, subtilase family, histidine active site. 218494003536 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003537 HMMPfam hit to PF02225, Protease-associated PA, score 6.9e-24 218494003538 PS00138 Serine proteases, subtilase family, serine active site. 218494003539 HMMPfam hit to PF06280, Peptidase S8A, DUF1034 C-terminal, score 7.7e-47 218494003540 HMMPfam hit to PF07554, Uncharacterised sugar-binding, score 1.8e-07 218494003541 HMMPfam hit to PF07554, Uncharacterised sugar-binding, score 3.2e-05 218494003542 HMMPfam hit to PF07554, Uncharacterised sugar-binding, score 1.6e-07 218494003543 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 7.7e-09 218494003544 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494003545 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 218494003546 putative substrate binding site [chemical binding]; other site 218494003547 putative ATP binding site [chemical binding]; other site 218494003548 HMMPfam hit to PF01256, Carbohydrate kinase, score 1.6e-68 218494003549 PS01050 Uncharacterized protein family UPF0031 signature 2. 218494003550 1 probable transmembrane helix predicted for SSU0758 by TMHMM2.0 at aa 21-43 218494003551 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 218494003552 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 218494003553 minor groove reading motif; other site 218494003554 helix-hairpin-helix signature motif; other site 218494003555 substrate binding pocket [chemical binding]; other site 218494003556 active site 218494003557 HMMPfam hit to PF00730, HhH-GPD, score 1.5e-26 218494003558 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 1.8e-09 218494003559 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 218494003560 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 218494003561 active site 218494003562 HMMPfam hit to PF00478, IMP dehydrogenase/GMP reductase, score 5.3e-148 218494003563 CDS contains a frameshift after codon 290. Similar to Escherichia coli multidrug resistance protein MdtK (multidrug-efflux transporter) UniProt:P37340 (EMBL:ECD809) (457 aa) fasta scores: E()=3.4e-38, 31.019% id in 432 aa, and to Streptococcus agalactiae serotype III hypothetical protein gbs1296 UniProt:Q8E4U8 (EMBL:SAG766850) (446 aa) fasta scores: E()=8.4e-96, 60.998% id in 441 aa 218494003564 7 probable transmembrane helices predicted for SSU0761 by TMHMM2.0 at aa 12-34, 54-76, 96-118, 133-150, 162-184, 194-216 and 251-273 218494003565 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 5.6e-32 218494003566 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 7e-07 218494003567 4 probable transmembrane helices predicted for SSU0762 by TMHMM2.0 at aa 7-26, 46-68, 75-97 and 107-129 218494003568 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 6.5e-16 218494003569 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 218494003570 RimM N-terminal domain; Region: RimM; pfam01782 218494003571 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 218494003572 HMMPfam hit to PF01782, RimM protein, score 2e-33 218494003573 HMMPfam hit to PF05239, PRC-barrel, score 3.4e-15 218494003574 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 218494003575 HMMPfam hit to PF01746, tRNA (guanine-N1-)-methyltransferase, score 1e-68 218494003576 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 218494003577 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218494003578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218494003579 homodimer interface [polypeptide binding]; other site 218494003580 catalytic residue [active] 218494003581 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 1e-31 218494003582 PS00599 Aminotransferases class-II pyridoxal-phosphate attachment site. 218494003583 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 218494003584 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494003585 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 218494003586 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 6.1e-22 218494003587 PS00894 Bacterial regulatory proteins, deoR family signature. 218494003588 Predicted helix-turn-helix motif with score 1316.000, SD 3.67 at aa 34-55, sequence VRLEELIEVLDTSESTVRRDLD 218494003589 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 7e-37 218494003590 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 218494003591 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 218494003592 putative substrate binding site [chemical binding]; other site 218494003593 putative ATP binding site [chemical binding]; other site 218494003594 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 1.9e-53 218494003595 PS00583 pfkB family of carbohydrate kinases signature 1. 218494003596 PS00584 pfkB family of carbohydrate kinases signature 2. 218494003597 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218494003598 active site 218494003599 phosphorylation site [posttranslational modification] 218494003600 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 218494003601 P-loop; other site 218494003602 active site 218494003603 phosphorylation site [posttranslational modification] 218494003604 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 218494003605 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 3.6e-24 218494003606 PS00372 PTS EIIA domains phosphorylation site signature 2. 218494003607 HMMPfam hit to PF02379, Phosphotransferase system, fructose-specific IIB subunit, score 1e-51 218494003608 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1.3e-17 218494003609 10 probable transmembrane helices predicted for SSU0768 by TMHMM2.0 at aa 303-325, 340-362, 374-396, 406-428, 441-463, 483-505, 526-548, 563-582, 589-611 and 626-648 218494003610 PS00583 pfkB family of carbohydrate kinases signature 1. 218494003611 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 218494003612 HMMPfam hit to PF06619, Protein of unknown function DUF1149, score 3e-69 218494003613 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 218494003614 HMMPfam hit to PF02645, DegV, score 1.3e-77 218494003615 dihydrodipicolinate reductase; Provisional; Region: PRK00048 218494003616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494003617 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 218494003618 HMMPfam hit to PF01113, Dihydrodipicolinate reductase, score 2.9e-44 218494003619 HMMPfam hit to PF05173, Dihydrodipicolinate reductase, score 2e-63 218494003620 PS01298 Dihydrodipicolinate reductase signature. 218494003621 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 218494003622 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 218494003623 active site 218494003624 NTP binding site [chemical binding]; other site 218494003625 metal binding triad [ion binding]; metal-binding site 218494003626 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 218494003627 HMMPfam hit to PF01743, Polynucleotide adenylyltransferase region, score 4.5e-57 218494003628 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 218494003629 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494003630 Walker A/P-loop; other site 218494003631 ATP binding site [chemical binding]; other site 218494003632 Q-loop/lid; other site 218494003633 ABC transporter signature motif; other site 218494003634 Walker B; other site 218494003635 D-loop; other site 218494003636 H-loop/switch region; other site 218494003637 ABC transporter; Region: ABC_tran_2; pfam12848 218494003638 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 218494003639 HMMPfam hit to PF00005, ABC transporter related, score 6.6e-39 218494003640 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003641 HMMPfam hit to PF00005, ABC transporter related, score 2.4e-35 218494003642 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003643 4 probable transmembrane helices predicted for SSU0774 by TMHMM2.0 at aa 4-26, 33-52, 62-79 and 86-108 218494003644 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 218494003645 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 218494003646 HMMPfam hit to PF00480, ROK, score 5e-52 218494003647 PS01125 ROK family signature. 218494003648 3 probable transmembrane helices predicted for SSU0776 by TMHMM2.0 at aa 9-31, 41-63 and 68-90 218494003649 3 probable transmembrane helices predicted for SSU0777 by TMHMM2.0 at aa 12-34, 44-61 and 68-90 218494003650 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 218494003651 dimerization interface [polypeptide binding]; other site 218494003652 active site 218494003653 HMMPfam hit to PF00303, Thymidylate synthase, C-terminal, score 7.5e-115 218494003654 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 218494003655 folate binding site [chemical binding]; other site 218494003656 NADP+ binding site [chemical binding]; other site 218494003657 HMMPfam hit to PF00186, Dihydrofolate reductase region, score 1.3e-50 218494003658 PS00075 Dihydrofolate reductase signature. 218494003659 2 probable transmembrane helices predicted for SSU0780 by TMHMM2.0 at aa 5-24 and 34-56 218494003660 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 218494003661 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 218494003662 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218494003663 Walker A motif; other site 218494003664 ATP binding site [chemical binding]; other site 218494003665 Walker B motif; other site 218494003666 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 218494003667 HMMPfam hit to PF06689, Zinc finger, C4-type, score 3.4e-23 218494003668 HMMPfam hit to PF07724, ATPase AAA-2, score 2.9e-77 218494003669 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003670 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 218494003671 G1 box; other site 218494003672 GTP/Mg2+ binding site [chemical binding]; other site 218494003673 Switch I region; other site 218494003674 G2 box; other site 218494003675 G3 box; other site 218494003676 Switch II region; other site 218494003677 G4 box; other site 218494003678 G5 box; other site 218494003679 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 4.1e-37 218494003680 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003681 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 218494003682 active site 218494003683 multimer interface [polypeptide binding]; other site 218494003684 HMMPfam hit to PF00334, Nucleoside diphosphate kinase, core, score 5.4e-63 218494003685 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 218494003686 HIRAN domain; Region: HIRAN; cl07418 218494003687 1 probable transmembrane helix predicted for SSU0784 by TMHMM2.0 at aa 41-63 218494003688 HMMPfam hit to PF08797, HIRAN, score 1.1e-11 218494003689 GTP-binding protein LepA; Provisional; Region: PRK05433 218494003690 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 218494003691 G1 box; other site 218494003692 putative GEF interaction site [polypeptide binding]; other site 218494003693 GTP/Mg2+ binding site [chemical binding]; other site 218494003694 Switch I region; other site 218494003695 G2 box; other site 218494003696 G3 box; other site 218494003697 Switch II region; other site 218494003698 G4 box; other site 218494003699 G5 box; other site 218494003700 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 218494003701 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 218494003702 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 218494003703 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 1.6e-72 218494003704 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003705 PS00301 GTP-binding elongation factors signature. 218494003706 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 1.2e-07 218494003707 HMMPfam hit to PF00679, Translation elongation factor EFG/EF2, C-terminal, score 4.9e-41 218494003708 HMMPfam hit to PF06421, GTP-binding protein LepA, C-terminal, score 4e-82 218494003709 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 218494003710 active site 1 [active] 218494003711 dimer interface [polypeptide binding]; other site 218494003712 hexamer interface [polypeptide binding]; other site 218494003713 active site 2 [active] 218494003714 HMMPfam hit to PF01361, 4-oxalocrotonate tautomerase, score 4.5e-27 218494003715 Excalibur calcium-binding domain; Region: Excalibur; cl05460 218494003716 1 probable transmembrane helix predicted for SSU0787 by TMHMM2.0 at aa 21-43 218494003717 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003718 HMMPfam hit to PF05901, Excalibur, score 6.5e-17 218494003719 Thymidine kinase; Region: TK; cl00631 218494003720 HMMPfam hit to PF00265, Thymidine kinase, score 3.7e-62 218494003721 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003722 PS00603 Thymidine kinase cellular-type signature. 218494003723 peptide chain release factor 1; Validated; Region: prfA; PRK00591 218494003724 RF-1 domain; Region: RF-1; cl02875 218494003725 RF-1 domain; Region: RF-1; cl02875 218494003726 HMMPfam hit to PF03462, PCRF, score 1.1e-65 218494003727 HMMPfam hit to PF00472, Class I peptide chain release factor, score 2.8e-59 218494003728 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 218494003729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218494003730 S-adenosylmethionine binding site [chemical binding]; other site 218494003731 HMMPfam hit to PF05175, Methyltransferase small, score 6.6e-13 218494003732 PS00092 N-6 Adenine-specific DNA methylases signature. 218494003733 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 218494003734 HMMPfam hit to PF01300, SUA5/yciO/yrdC, N-terminal, score 5.6e-35 218494003735 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 218494003736 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218494003737 Coenzyme A binding pocket [chemical binding]; other site 218494003738 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 5.5e-17 218494003739 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 218494003740 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 218494003741 dimer interface [polypeptide binding]; other site 218494003742 glycine-pyridoxal phosphate binding site [chemical binding]; other site 218494003743 active site 218494003744 folate binding site [chemical binding]; other site 218494003745 HMMPfam hit to PF00464, Glycine hydroxymethyltransferase, score 5.6e-247 218494003746 PS00096 Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. 218494003747 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 218494003748 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 218494003749 1 probable transmembrane helix predicted for SSU0796 by TMHMM2.0 at aa 4-21 218494003750 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 218494003751 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494003752 NAD(P) binding site [chemical binding]; other site 218494003753 active site 218494003754 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 7.4e-22 218494003755 PS00061 Short-chain dehydrogenases/reductases family signature. 218494003756 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494003757 HIRAN domain; Region: HIRAN; cl07418 218494003758 HMMPfam hit to PF08797, HIRAN, score 2.9e-22 218494003759 1 probable transmembrane helix predicted for SSU0801 by TMHMM2.0 at aa 7-29 218494003760 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494003761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218494003762 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 218494003763 Walker A motif; other site 218494003764 ATP binding site [chemical binding]; other site 218494003765 Walker B motif; other site 218494003766 arginine finger; other site 218494003767 HMMPfam hit to PF07728, ATPase associated with various cellular activities, AAA-5, score 1e-31 218494003768 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003769 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 218494003770 genomic island 218494003771 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 218494003772 Phage integrase family; Region: Phage_integrase; pfam00589 218494003773 Int/Topo IB signature motif; other site 218494003774 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 1.1e-17 218494003775 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 218494003776 Plasmid replication protein; Region: Rep_2; pfam01719 218494003777 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494003778 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003779 HMMPfam hit to PF01719, Plasmid replication protein, score 1.8e-05 218494003780 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494003781 3 probable transmembrane helices predicted for SSU0811 by TMHMM2.0 at aa 60-79, 84-106 and 126-148 218494003782 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494003783 phosphodiesterase; Provisional; Region: PRK12704 218494003784 GMP synthase; Reviewed; Region: guaA; PRK00074 218494003785 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 218494003786 AMP/PPi binding site [chemical binding]; other site 218494003787 candidate oxyanion hole; other site 218494003788 catalytic triad [active] 218494003789 potential glutamine specificity residues [chemical binding]; other site 218494003790 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 218494003791 ATP Binding subdomain [chemical binding]; other site 218494003792 Dimerization subdomain; other site 218494003793 HMMPfam hit to PF00958, GMP synthase, C-terminal, score 3.5e-55 218494003794 HMMPfam hit to PF02540, NAD+ synthase, score 4.8e-06 218494003795 HMMPfam hit to PF00117, Glutamine amidotransferase class-I, score 3.9e-57 218494003796 PS00442 Glutamine amidotransferases class-I active site. 218494003797 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 218494003798 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218494003799 DNA-binding site [nucleotide binding]; DNA binding site 218494003800 UTRA domain; Region: UTRA; cl01230 218494003801 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 1.2e-25 218494003802 PS00043 Bacterial regulatory proteins, gntR family signature. 218494003803 Predicted helix-turn-helix motif with score 1595.000, SD 4.62 at aa 28-49, sequence PSERDLADEFGVSRMTLRQGIT 218494003804 HMMPfam hit to PF07702, UbiC transcription regulator-associated, score 3e-48 218494003805 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 218494003806 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 218494003807 HMMPfam hit to PF04297, helix-turn-helix protein, YlxM/p13-like, score 2.8e-61 218494003808 Predicted helix-turn-helix motif with score 1623.000, SD 4.71 at aa 39-60, sequence YSLAEIAEEFQVSRQAVYDNIK 218494003809 signal recognition particle protein; Provisional; Region: PRK10867 218494003810 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 218494003811 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 218494003812 P loop; other site 218494003813 GTP binding site [chemical binding]; other site 218494003814 Signal peptide binding domain; Region: SRP_SPB; pfam02978 218494003815 HMMPfam hit to PF02881, Signal recognition particle, SRP54 subunit, helical bundle, score 9.4e-34 218494003816 HMMPfam hit to PF00448, Signal recognition particle, SRP54 subunit, GTPase, score 3.1e-116 218494003817 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003818 PS00300 SRP54-type proteins GTP-binding domain signature. 218494003819 HMMPfam hit to PF02978, Signal recognition particle, SRP54 subunit, M-domain, score 1.1e-54 218494003820 Predicted helix-turn-helix motif with score 1609.000, SD 4.67 at aa 175-196, sequence FTQKPIAEKMKLSQSAFTKRLK 218494003821 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 218494003822 6 probable transmembrane helices predicted for SSU0821 by TMHMM2.0 at aa 10-32, 45-67, 109-131, 138-160, 188-210 and 223-245 218494003823 Probable gene remnant, possible N-terminal region of pseudogene. Similar to the N-terminal region of Bacillus subtilis tunicamycin resistance protein TmrB UniProt:P12921 (EMBL:BSTMR1) (197 aa) fasta scores: E()=2.7e-17, 40.690% id in 145 aa, and to the full length Oceanobacillus iheyensis tunicamycin resistance protein UniProt:Q8CUX6 (EMBL:BA000028) (137 aa) fasta scores: E()=2.8e-21, 52.756% id in 127 aa. Downstream of the CDS is a large in-frame ORF, however this does not match the C-terminal region of Bacillus subtilis tunicamycin resistance protein 218494003824 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003825 CDS contains a frameshift after codon 99. Similar to Enterococcus faecalis (Streptococcus faecalis) hypothetical protein UniProt:Q832Y3 (EMBL:AE016953) (322 aa) fasta scores: E()=5.1e-46, 43.709% id in 302 aa 218494003826 HMMPfam hit to PF07751, Abortive infection bacteriophage resistance related, score 1.2e-24 218494003827 HMMPfam hit to PF07751, Abortive infection bacteriophage resistance related, score 2.2e-24 218494003828 1 probable transmembrane helix predicted for SSU0824 by TMHMM2.0 at aa 20-42 218494003829 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 218494003830 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 218494003831 DNA binding site [nucleotide binding] 218494003832 Int/Topo IB signature motif; other site 218494003833 active site 218494003834 HMMPfam hit to PF02899, Integrase, N-terminal SAM-like, phage, score 0.0025 218494003835 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 1.2e-16 218494003836 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 218494003837 active site 218494003838 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 218494003839 substrate binding site [chemical binding]; other site 218494003840 metal binding site [ion binding]; metal-binding site 218494003841 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III, score 0.065 218494003842 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II, score 1.6e-22 218494003843 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I, score 1.9e-23 218494003844 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 218494003845 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 218494003846 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218494003847 ATP binding site [chemical binding]; other site 218494003848 Mg2+ binding site [ion binding]; other site 218494003849 G-X-G motif; other site 218494003850 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 7.6e-20 218494003851 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 0.0052 218494003852 2 probable transmembrane helices predicted for SSU0827 by TMHMM2.0 at aa 12-30 and 40-57 218494003853 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 218494003854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218494003855 active site 218494003856 phosphorylation site [posttranslational modification] 218494003857 intermolecular recognition site; other site 218494003858 dimerization interface [polypeptide binding]; other site 218494003859 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218494003860 DNA binding site [nucleotide binding] 218494003861 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 1.8e-25 218494003862 HMMPfam hit to PF00072, Response regulator receiver, score 4e-23 218494003863 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 218494003864 HMMPfam hit to PF05016, Plasmid stabilization system, score 5.5e-08 218494003865 10 probable transmembrane helices predicted for SSU0831 by TMHMM2.0 at aa 17-39, 54-76, 97-131, 146-168, 192-211, 226-248, 280-302, 531-553, 587-609 and 624-643 218494003866 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003867 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 218494003868 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 218494003869 Walker A/P-loop; other site 218494003870 ATP binding site [chemical binding]; other site 218494003871 Q-loop/lid; other site 218494003872 ABC transporter signature motif; other site 218494003873 Walker B; other site 218494003874 D-loop; other site 218494003875 H-loop/switch region; other site 218494003876 HMMPfam hit to PF00005, ABC transporter related, score 7.3e-65 218494003877 PS00211 ABC transporters family signature. 218494003878 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003879 ABC-2 type transporter; Region: ABC2_membrane; cl11417 218494003880 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 218494003881 6 probable transmembrane helices predicted for SSU0833 by TMHMM2.0 at aa 17-36, 56-78, 104-126, 136-158, 171-193 and 213-235 218494003882 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 218494003883 6 probable transmembrane helices predicted for SSU0834 by TMHMM2.0 at aa 17-39, 59-76, 102-124, 134-156, 163-180 and 225-243 218494003884 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 218494003885 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 218494003886 Walker A/P-loop; other site 218494003887 ATP binding site [chemical binding]; other site 218494003888 Q-loop/lid; other site 218494003889 ABC transporter signature motif; other site 218494003890 Walker B; other site 218494003891 D-loop; other site 218494003892 H-loop/switch region; other site 218494003893 HMMPfam hit to PF00005, ABC transporter related, score 7.2e-54 218494003894 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003895 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494003896 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 218494003897 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 218494003898 Putative esterase; Region: Esterase; pfam00756 218494003899 HMMPfam hit to PF00756, esterase, score 0.00018 218494003900 PS00237 G-protein coupled receptors signature. 218494003901 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 218494003902 Putative esterase; Region: Esterase; pfam00756 218494003903 HMMPfam hit to PF00756, esterase, score 5.3e-08 218494003904 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 218494003905 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218494003906 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 218494003907 HMMPfam hit to PF06445, Bacterial transcription activator, effector binding, score 3.1e-28 218494003908 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 7.1e-05 218494003909 PS00041 Bacterial regulatory proteins, araC family signature. 218494003910 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 218494003911 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 218494003912 HMMPfam hit to PF01134, Glucose-inhibited division protein A, score 6.2e-188 218494003913 PS01281 Glucose inhibited division protein A family signature 2. 218494003914 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 218494003915 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218494003916 motif II; other site 218494003917 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 9.1e-21 218494003918 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 218494003919 core dimer interface [polypeptide binding]; other site 218494003920 L10 interface [polypeptide binding]; other site 218494003921 L11 interface [polypeptide binding]; other site 218494003922 putative EF-Tu interaction site [polypeptide binding]; other site 218494003923 putative EF-G interaction site [polypeptide binding]; other site 218494003924 HMMPfam hit to PF00542, Ribosomal protein L7/L12, C-terminal, score 9.5e-38 218494003925 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 218494003926 23S rRNA interface [nucleotide binding]; other site 218494003927 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 218494003928 HMMPfam hit to PF00466, Ribosomal protein L10, score 7.9e-25 218494003929 DNA topoisomerase I; Validated; Region: PRK05582 218494003930 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 218494003931 active site 218494003932 interdomain interaction site; other site 218494003933 putative metal-binding site [ion binding]; other site 218494003934 nucleotide binding site [chemical binding]; other site 218494003935 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 218494003936 domain I; other site 218494003937 DNA binding groove [nucleotide binding] 218494003938 phosphate binding site [ion binding]; other site 218494003939 domain II; other site 218494003940 domain III; other site 218494003941 nucleotide binding site [chemical binding]; other site 218494003942 catalytic site [active] 218494003943 domain IV; other site 218494003944 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 218494003945 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 218494003946 HMMPfam hit to PF01396, DNA topoisomerase, type IA, zn finger, score 7.5e-14 218494003947 HMMPfam hit to PF01396, DNA topoisomerase, type IA, zn finger, score 1.2e-15 218494003948 HMMPfam hit to PF01131, DNA topoisomerase, type IA, central, score 3.2e-171 218494003949 PS00396 Prokaryotic DNA topoisomerase I active site. 218494003950 HMMPfam hit to PF01751, TOPRIM, score 5.3e-34 218494003951 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 218494003952 HMMPfam hit to PF02481, SMF protein, score 1.3e-83 218494003953 PS00017 ATP/GTP-binding site motif A (P-loop). 218494003954 maltose O-acetyltransferase; Provisional; Region: PRK10092 218494003955 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 218494003956 active site 218494003957 substrate binding site [chemical binding]; other site 218494003958 trimer interface [polypeptide binding]; other site 218494003959 CoA binding site [chemical binding]; other site 218494003960 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 218494003961 putative homotetramer interface [polypeptide binding]; other site 218494003962 putative homodimer interface [polypeptide binding]; other site 218494003963 putative metal binding site [ion binding]; other site 218494003964 putative homodimer-homodimer interface [polypeptide binding]; other site 218494003965 putative allosteric switch controlling residues; other site 218494003966 HMMPfam hit to PF02583, Protein of unknown function DUF156, score 1e-32 218494003967 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 218494003968 active site residue [active] 218494003969 HMMPfam hit to PF00581, Rhodanese-like, score 4.3e-11 218494003970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494003971 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 218494003972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494003973 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 218494003974 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 218494003975 active site residue [active] 218494003976 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 5e-45 218494003977 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 9e-28 218494003978 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidoreductase dimerisation region, score 4.4e-10 218494003979 HMMPfam hit to PF00581, Rhodanese-like, score 1e-06 218494003980 PS00215 Mitochondrial energy transfer proteins signature. 218494003981 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 218494003982 HMMPfam hit to PF08876, Protein of unknown function DUF1836, score 6e-63 218494003983 Haemolysin-III related; Region: HlyIII; cl03831 218494003984 HMMPfam hit to PF03006, Hly-III related proteins, score 2e-62 218494003985 6 probable transmembrane helices predicted for SSU0854 by TMHMM2.0 at aa 20-42, 49-71, 106-128, 141-160, 164-186 and 193-215 218494003986 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 218494003987 putative active site [active] 218494003988 6 probable transmembrane helices predicted for SSU0855 by TMHMM2.0 at aa 4-21, 26-48, 61-83, 96-118, 133-155 and 316-335 218494003989 HMMPfam hit to PF02698, Protein of unknown function DUF218, score 3e-55 218494003990 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 218494003991 RNA/DNA hybrid binding site [nucleotide binding]; other site 218494003992 active site 218494003993 HMMPfam hit to PF01351, Ribonuclease HII/HIII, score 5.3e-69 218494003994 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 218494003995 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The...; Region: YlqF; cd01856 218494003996 GTP/Mg2+ binding site [chemical binding]; other site 218494003997 G4 box; other site 218494003998 G5 box; other site 218494003999 G1 box; other site 218494004000 Switch I region; other site 218494004001 G2 box; other site 218494004002 G3 box; other site 218494004003 Switch II region; other site 218494004004 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 4.6e-21 218494004005 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004006 Flagellin N-methylase; Region: FliB; cl00497 218494004007 HMMPfam hit to PF03692, Protein of unknown function UPF0153, score 2.8e-26 218494004008 Maf-like protein; Region: Maf; pfam02545 218494004009 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 218494004010 active site 218494004011 dimer interface [polypeptide binding]; other site 218494004012 HMMPfam hit to PF02545, Maf-like protein, score 7.7e-24 218494004013 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 218494004014 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 218494004015 putative active site [active] 218494004016 putative metal binding site [ion binding]; other site 218494004017 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 218494004018 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 1.8e-07 218494004019 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494004020 HMMPfam hit to PF02872, 5'-Nucleotidase, C-terminal, score 2.8e-45 218494004021 HMMPfam hit to PF00149, Metallophosphoesterase, score 8.8e-11 218494004022 PS00786 5'-nucleotidase signature 2. 218494004023 dihydroorotase; Validated; Region: pyrC; PRK09357 218494004024 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 218494004025 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 218494004026 active site 218494004027 HMMPfam hit to PF01979, Amidohydrolase 1, score 6.4e-18 218494004028 PS00483 Dihydroorotase signature 2. 218494004029 PS00482 Dihydroorotase signature 1. 218494004030 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 218494004031 ligand binding site [chemical binding]; other site 218494004032 active site 218494004033 UGI interface [polypeptide binding]; other site 218494004034 catalytic site [active] 218494004035 HMMPfam hit to PF03167, Uracil-DNA glycosylase superfamily, score 6.4e-71 218494004036 PS00130 Uracil-DNA glycosylase signature. 218494004037 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 218494004038 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 218494004039 Ligand binding site; other site 218494004040 Putative Catalytic site; other site 218494004041 DXD motif; other site 218494004042 2 probable transmembrane helices predicted for SSU0863 by TMHMM2.0 at aa 228-250 and 265-287 218494004043 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 3.2e-32 218494004044 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 218494004045 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 3.9e-32 218494004046 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 218494004047 PS00626 Regulator of chromosome condensation (RCC1) signature 2. 218494004048 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217 218494004049 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 218494004050 active site 218494004051 dimer interface [polypeptide binding]; other site 218494004052 HMMPfam hit to PF00215, Orotidine 5'-phosphate decarboxylase, core, score 1.6e-80 218494004053 PS00156 Orotidine 5'-phosphate decarboxylase active site. 218494004054 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 218494004055 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 218494004056 heterodimer interface [polypeptide binding]; other site 218494004057 active site 218494004058 FMN binding site [chemical binding]; other site 218494004059 homodimer interface [polypeptide binding]; other site 218494004060 substrate binding site [chemical binding]; other site 218494004061 HMMPfam hit to PF01180, Dihydroorotate dehydrogenase, core, score 1.6e-139 218494004062 PS00912 Dihydroorotate dehydrogenase signature 2. 218494004063 PS00911 Dihydroorotate dehydrogenase signature 1. 218494004064 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 218494004065 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 218494004066 FAD binding pocket [chemical binding]; other site 218494004067 FAD binding motif [chemical binding]; other site 218494004068 phosphate binding motif [ion binding]; other site 218494004069 beta-alpha-beta structure motif; other site 218494004070 NAD binding pocket [chemical binding]; other site 218494004071 Iron coordination center [ion binding]; other site 218494004072 HMMPfam hit to PF00175, Oxidoreductase FAD/NAD(P)-binding, score 2.3e-26 218494004073 HMMPfam hit to PF00970, Oxidoreductase FAD-binding region, score 4.7e-06 218494004074 Transcriptional regulator [Transcription]; Region: LysR; COG0583 218494004075 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494004076 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 218494004077 dimerization interface [polypeptide binding]; other site 218494004078 HMMPfam hit to PF00126, Bacterial regulatory protein, LysR, score 6.1e-16 218494004079 Predicted helix-turn-helix motif with score 1533.000, SD 4.41 at aa 16-37, sequence GSMNEAAKQLFITQPSLSNAVR 218494004080 PS00044 Bacterial regulatory proteins, lysR family signature. 218494004081 HMMPfam hit to PF03466, LysR, substrate-binding, score 1.4e-06 218494004082 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 218494004083 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 218494004084 ligand binding site; other site 218494004085 oligomer interface; other site 218494004086 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 218494004087 dimer interface [polypeptide binding]; other site 218494004088 N-terminal domain interface [polypeptide binding]; other site 218494004089 sulfate 1 binding site; other site 218494004090 HMMPfam hit to PF00483, Nucleotidyl transferase, score 4e-88 218494004091 PS00808 ADP-glucose pyrophosphorylase signature 1. 218494004092 PS00810 ADP-glucose pyrophosphorylase signature 3. 218494004093 CDS contains a nonsense mutation (ochre) after codon 54. Similar to Bacillus subtilis glucose-1-phosphate adenylyltransferase GlgC UniProt:P39122 (EMBL:AF008220) (380 aa) blastp scores: E()=3e-21 218494004094 glycogen synthase; Provisional; Region: glgA; PRK00654 218494004095 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 218494004096 ADP-binding pocket [chemical binding]; other site 218494004097 homodimer interface [polypeptide binding]; other site 218494004098 HMMPfam hit to PF08323, Starch synthase catalytic region, score 2.6e-92 218494004099 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 0.0003 218494004100 glycogen branching enzyme; Provisional; Region: PRK05402 218494004101 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 218494004102 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 218494004103 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 218494004104 HMMPfam hit to PF02922, Glycoside hydrolase, family 13, N-terminal, score 7.4e-18 218494004105 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 2.4e-10 218494004106 HMMPfam hit to PF02806, Alpha-amylase, C-terminal all beta, score 0.0014 218494004107 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218494004108 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 218494004109 substrate binding pocket [chemical binding]; other site 218494004110 membrane-bound complex binding site; other site 218494004111 hinge residues; other site 218494004112 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 4.8e-64 218494004113 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494004114 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218494004115 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 218494004116 substrate binding pocket [chemical binding]; other site 218494004117 membrane-bound complex binding site; other site 218494004118 hinge residues; other site 218494004119 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 1.2e-57 218494004120 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494004121 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 218494004122 putative active site [active] 218494004123 nucleotide binding site [chemical binding]; other site 218494004124 nudix motif; other site 218494004125 putative metal binding site [ion binding]; other site 218494004126 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 1.1e-20 218494004127 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218494004128 PS00893 mutT domain signature. 218494004129 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 218494004130 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218494004131 Coenzyme A binding pocket [chemical binding]; other site 218494004132 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.4e-19 218494004133 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 218494004134 G5 domain; Region: G5; pfam07501 218494004135 G5 domain; Region: G5; pfam07501 218494004136 G5 domain; Region: G5; pfam07501 218494004137 G5 domain; Region: G5; pfam07501 218494004138 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 218494004139 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 218494004140 HMMPfam hit to PF07580, Peptidase M26, IgA1-specific C-terminal, score 3.3e-268 218494004141 PS00012 Phosphopantetheine attachment site. 218494004142 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218494004143 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004144 HMMPfam hit to PF07581, GLUG, score 0.09 218494004145 HMMPfam hit to PF07581, GLUG, score 0.8 218494004146 HMMPfam hit to PF05342, Peptidase M26, score 1.1e-68 218494004147 HMMPfam hit to PF07501, G5, score 1.2e-16 218494004148 HMMPfam hit to PF07501, G5, score 2.8e-11 218494004149 HMMPfam hit to PF07501, G5, score 1.4e-20 218494004150 HMMPfam hit to PF07501, G5, score 6e-21 218494004151 3 probable transmembrane helices predicted for SSU0879 by TMHMM2.0 at aa 19-41, 105-127 and 134-156 218494004152 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 0.00058 218494004153 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494004154 HMMPfam hit to PF04650, YSIRK Gram-positive signal peptide, score 8.5e-07 218494004155 Probable gene remnant, CDS lacks a translational start site. Similar to C-terminus of Streptococcus pneumoniae (strain ATCC BAA-255/R6) UvrABC system protein B UvrB UniProt:Q8DPK7 (EMBL:AE008484) (662 aa) fasta scores: E()=2.5e-06, 78.125% id in 32 aa. Identical to the C-terminus of SSU0882, 100.000% identity (100.000% ungapped) in 32 aa overlap (4-35:630-661) 218494004156 HMMPfam hit to PF02151, UvrB/UvrC protein, score 7.2e-08 218494004157 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 218494004158 excinuclease ABC subunit B; Provisional; Region: PRK05298 218494004159 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218494004160 ATP binding site [chemical binding]; other site 218494004161 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218494004162 nucleotide binding region [chemical binding]; other site 218494004163 ATP-binding site [chemical binding]; other site 218494004164 Ultra-violet resistance protein B; Region: UvrB; pfam12344 218494004165 UvrB/uvrC motif; Region: UVR; pfam02151 218494004166 HMMPfam hit to PF02151, UvrB/UvrC protein, score 5e-11 218494004167 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 3.4e-21 218494004168 HMMPfam hit to PF04851, Restriction endonuclease, type I, R subunit/Type III, Res subunit, score 1.1e-12 218494004169 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004170 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 218494004171 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218494004172 substrate binding pocket [chemical binding]; other site 218494004173 membrane-bound complex binding site; other site 218494004174 hinge residues; other site 218494004175 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 218494004176 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218494004177 substrate binding pocket [chemical binding]; other site 218494004178 membrane-bound complex binding site; other site 218494004179 hinge residues; other site 218494004180 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218494004181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494004182 dimer interface [polypeptide binding]; other site 218494004183 conserved gate region; other site 218494004184 putative PBP binding loops; other site 218494004185 ABC-ATPase subunit interface; other site 218494004186 5 probable transmembrane helices predicted for SSU0883 by TMHMM2.0 at aa 5-22, 531-553, 566-588, 667-689 and 702-724 218494004187 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 1.8e-74 218494004188 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 3.2e-78 218494004189 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.3e-26 218494004190 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218494004191 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 218494004192 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 218494004193 Walker A/P-loop; other site 218494004194 ATP binding site [chemical binding]; other site 218494004195 Q-loop/lid; other site 218494004196 ABC transporter signature motif; other site 218494004197 Walker B; other site 218494004198 D-loop; other site 218494004199 H-loop/switch region; other site 218494004200 HMMPfam hit to PF00005, ABC transporter related, score 1.4e-64 218494004201 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004202 PS00211 ABC transporters family signature. 218494004203 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 218494004204 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 0.00061 218494004205 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494004206 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 218494004207 Walker A/P-loop; other site 218494004208 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494004209 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 218494004210 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 218494004211 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004212 HMMPfam hit to PF00005, ABC transporter related, score 1.3e-17 218494004213 HMMPfam hit to PF00005, ABC transporter related, score 5.4e-27 218494004214 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004215 PS00211 ABC transporters family signature. 218494004216 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 218494004217 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 218494004218 homodimer interface [polypeptide binding]; other site 218494004219 substrate-cofactor binding pocket; other site 218494004220 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218494004221 catalytic residue [active] 218494004222 HMMPfam hit to PF01053, Cys/Met metabolism, pyridoxal phosphate-dependent enzyme, score 4.6e-202 218494004223 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 218494004224 1 probable transmembrane helix predicted for SSU0888 by TMHMM2.0 at aa 4-23 218494004225 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 218494004226 active site 218494004227 catalytic residues [active] 218494004228 HMMPfam hit to PF01263, Aldose 1-epimerase, score 4e-29 218494004229 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 218494004230 HMMPfam hit to PF00232, Glycoside hydrolase, family 1, score 9.8e-253 218494004231 PS00572 Glycosyl hydrolases family 1 active site. 218494004232 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218494004233 PS00653 Glycosyl hydrolases family 1 N-terminal signature. 218494004234 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 218494004235 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 218494004236 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 218494004237 P-loop; other site 218494004238 active site 218494004239 phosphorylation site [posttranslational modification] 218494004240 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 1.5e-33 218494004241 8 probable transmembrane helices predicted for SSU0892 by TMHMM2.0 at aa 30-52, 62-84, 105-124, 139-156, 221-240, 281-303, 332-354 and 378-400 218494004242 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 2.1e-106 218494004243 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 218494004244 methionine cluster; other site 218494004245 active site 218494004246 phosphorylation site [posttranslational modification] 218494004247 metal binding site [ion binding]; metal-binding site 218494004248 HMMPfam hit to PF02255, Phosphotransferase system, lactose/cellobiose-specific IIA subunit, score 3.5e-56 218494004249 transcriptional antiterminator BglG; Provisional; Region: PRK09772 218494004250 CAT RNA binding domain; Region: CAT_RBD; cl03904 218494004251 PRD domain; Region: PRD; cl15445 218494004252 PRD domain; Region: PRD; cl15445 218494004253 HMMPfam hit to PF00874, PRD, score 1.7e-09 218494004254 HMMPfam hit to PF00874, PRD, score 3.8e-11 218494004255 HMMPfam hit to PF03123, CAT RNA-binding region, score 1e-18 218494004256 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 218494004257 HMMPfam hit to PF01791, Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase, score 2.2e-104 218494004258 CDS contains a frameshift after codon 28. Frameshift occurs at a poly A hexamer. Similar to Staphylococcus aureus (strain MW2) tagatose-6-phosphate kinase LacC UniProt:P0A0B8 (EMBL:BA000033) (310 aa) fasta scores: E()=8e-64, 61.613% id in 310 aa 218494004259 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 2.1e-43 218494004260 PS00584 pfkB family of carbohydrate kinases signature 2. 218494004261 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 218494004262 HMMPfam hit to PF02502, Ribose/galactose isomerase, score 1.1e-62 218494004263 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 218494004264 HMMPfam hit to PF02502, Ribose/galactose isomerase, score 3.8e-53 218494004265 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 218494004266 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494004267 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 218494004268 HMMPfam hit to PF00455, Bacterial regulatory protein, DeoR, score 8.3e-63 218494004269 HMMPfam hit to PF08220, Bacterial regulatory protein, DeoR N-terminal, score 2.5e-26 218494004270 Predicted helix-turn-helix motif with score 1337.000, SD 3.74 at aa 20-41, sequence VRISEIVELLNVTDMTVRRDFI 218494004271 PS00894 Bacterial regulatory proteins, deoR family signature. 218494004272 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 218494004273 Predicted helix-turn-helix motif with score 1336.000, SD 3.74 at aa 11-32, sequence LNRQQVAELLGIDPKSFGKYIR 218494004274 CDS contains a nonsense mutation (opal) after codon 263. Similar to Leuconostoc oenos bacteriophage 10MC integrase Int UniProt:Q9ZXG6 (EMBL:U77495) (348 aa) fasta scores: E()=1.1e-20, 29.060% id in 351 aa 218494004275 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 0.00013 218494004276 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 4.9e-06 218494004277 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218494004278 non-specific DNA binding site [nucleotide binding]; other site 218494004279 salt bridge; other site 218494004280 sequence-specific DNA binding site [nucleotide binding]; other site 218494004281 Predicted transcriptional regulator [Transcription]; Region: COG2932 218494004282 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 218494004283 Catalytic site [active] 218494004284 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 1.1e-07 218494004285 Predicted helix-turn-helix motif with score 1295.000, SD 3.60 at aa 16-37, sequence LSMDKFAELSGLTKGYISMLEK 218494004286 HMMPfam hit to PF00717, Peptidase S24, S26A and S26B, C-terminal, score 6.2e-11 218494004287 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 218494004288 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 218494004289 minor groove reading motif; other site 218494004290 helix-hairpin-helix signature motif; other site 218494004291 substrate binding pocket [chemical binding]; other site 218494004292 active site 218494004293 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 218494004294 DNA binding and oxoG recognition site [nucleotide binding] 218494004295 HMMPfam hit to PF00730, HhH-GPD, score 2.5e-15 218494004296 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 4.1e-07 218494004297 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 218494004298 CoenzymeA binding site [chemical binding]; other site 218494004299 subunit interaction site [polypeptide binding]; other site 218494004300 PHB binding site; other site 218494004301 HMMPfam hit to PF03061, Thioesterase superfamily, score 1.4e-16 218494004302 PS00430 TonB-dependent receptor proteins signature 1. 218494004303 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 218494004304 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 218494004305 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 218494004306 Walker A/P-loop; other site 218494004307 ATP binding site [chemical binding]; other site 218494004308 Q-loop/lid; other site 218494004309 ABC transporter signature motif; other site 218494004310 Walker B; other site 218494004311 D-loop; other site 218494004312 H-loop/switch region; other site 218494004313 HMMPfam hit to PF00005, ABC transporter related, score 2.1e-59 218494004314 PS00211 ABC transporters family signature. 218494004315 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004316 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 218494004317 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 2.9e-27 218494004318 5 probable transmembrane helices predicted for SSU0911 by TMHMM2.0 at aa 20-42, 57-79, 127-149, 159-178 and 249-271 218494004319 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 218494004320 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 218494004321 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494004322 Walker A/P-loop; other site 218494004323 ATP binding site [chemical binding]; other site 218494004324 Q-loop/lid; other site 218494004325 ABC transporter signature motif; other site 218494004326 Walker B; other site 218494004327 D-loop; other site 218494004328 H-loop/switch region; other site 218494004329 HMMPfam hit to PF00005, ABC transporter related, score 5.7e-43 218494004330 PS00211 ABC transporters family signature. 218494004331 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004332 6 probable transmembrane helices predicted for SSU0912 by TMHMM2.0 at aa 21-40, 50-72, 133-151, 155-177, 234-256 and 271-293 218494004333 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 3.6e-34 218494004334 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 218494004335 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 218494004336 HMMPfam hit to PF01515, Phosphate acetyl/butaryl transferase, score 5.5e-160 218494004337 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 218494004338 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 218494004339 active site 218494004340 HMMPfam hit to PF00849, Pseudouridine synthase, score 9.5e-45 218494004341 PS01129 Rlu family of pseudouridine synthase signature. 218494004342 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 218494004343 HMMPfam hit to PF01513, ATP-NAD/AcoX kinase, score 2e-39 218494004344 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 218494004345 synthetase active site [active] 218494004346 NTP binding site [chemical binding]; other site 218494004347 metal binding site [ion binding]; metal-binding site 218494004348 HMMPfam hit to PF04607, RelA/SpoT, score 2.1e-45 218494004349 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 218494004350 putative active site [active] 218494004351 putative metal binding residues [ion binding]; other site 218494004352 signature motif; other site 218494004353 putative triphosphate binding site [ion binding]; other site 218494004354 HMMPfam hit to PF01928, Adenylate cyclase, score 9.7e-33 218494004355 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 218494004356 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 218494004357 PS00114 Phosphoribosyl pyrophosphate synthetase signature. 218494004358 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 1.4e-15 218494004359 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 218494004360 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 218494004361 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218494004362 catalytic residue [active] 218494004363 HMMPfam hit to PF00266, Aminotransferase, class V, score 4.5e-85 218494004364 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 218494004365 Domain of unknown function (DUF1831); Region: DUF1831; pfam08866 218494004366 HMMPfam hit to PF08866, Protein of unknown function DUF1831, score 6.9e-80 218494004367 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 218494004368 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 218494004369 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494004370 HMMPfam hit to PF06971, Rex DNA-binding, C-terminal, score 5.2e-27 218494004371 Predicted helix-turn-helix motif with score 1119.000, SD 3.00 at aa 35-56, sequence ASSKEIAEAIGIDSATVRRDFS 218494004372 HMMPfam hit to PF02629, CoA-binding, score 1.2e-36 218494004373 Peptidase C26; Region: Peptidase_C26; pfam07722 218494004374 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 218494004375 catalytic triad [active] 218494004376 HMMPfam hit to PF07722, Peptidase C26, score 6.6e-108 218494004377 hypothetical protein; Reviewed; Region: PRK00024 218494004378 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 218494004379 MPN+ (JAMM) motif; other site 218494004380 Zinc-binding site [ion binding]; other site 218494004381 HMMPfam hit to PF04002, DNA repair protein RadC, score 2.8e-66 218494004382 PS01302 DNA repair protein radC family signature. 218494004383 HMMPfam hit to PF00633, Helix-hairpin-helix motif, score 1.5e-05 218494004384 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 218494004385 active site 218494004386 catalytic site [active] 218494004387 HMMPfam hit to PF04203, Peptidase C60, sortase A and B, score 8.5e-50 218494004388 1 probable transmembrane helix predicted for SSU0925 by TMHMM2.0 at aa 13-32 218494004389 DNA gyrase subunit A; Validated; Region: PRK05560 218494004390 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 218494004391 CAP-like domain; other site 218494004392 active site 218494004393 primary dimer interface [polypeptide binding]; other site 218494004394 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218494004395 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218494004396 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218494004397 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218494004398 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218494004399 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 218494004400 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 4.5e-12 218494004401 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 1.1e-14 218494004402 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 3.1e-15 218494004403 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 4.7e-14 218494004404 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 1.3e-16 218494004405 HMMPfam hit to PF03989, DNA gyrase/topoisomerase IV, subunit A, C-terminal beta-pinwheel, score 2.7e-12 218494004406 HMMPfam hit to PF00521, DNA topoisomerase, type IIA, subunit A or C-terminal, score 0 218494004407 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004408 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 218494004409 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 218494004410 tetramer (dimer of dimers) interface [polypeptide binding]; other site 218494004411 NAD binding site [chemical binding]; other site 218494004412 dimer interface [polypeptide binding]; other site 218494004413 substrate binding site [chemical binding]; other site 218494004414 HMMPfam hit to PF00056, Lactate/malate dehydrogenase, score 4e-74 218494004415 HMMPfam hit to PF02866, Lactate/malate dehydrogenase, score 4.2e-75 218494004416 PS00064 L-lactate dehydrogenase active site. 218494004417 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218494004418 CDS contains a nonsense mutation (amber) after codon 101. Similar to Bacillus subtilis hypothetical protein YwjB UniProt:P45862 (EMBL:BSDNA320D) (174 aa) fasta scores: E()=3.7e-14, 36.111% id in 180 aa 218494004419 HMMPfam hit to PF01872, Bacterial bifunctional deaminase-reductase, C-terminal, score 4.2e-08 218494004420 HMMPfam hit to PF01872, Bacterial bifunctional deaminase-reductase, C-terminal, score 4.1e-08 218494004421 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 218494004422 TM-ABC transporter signature motif; other site 218494004423 10 probable transmembrane helices predicted for SSU0930 by TMHMM2.0 at aa 7-29, 34-56, 68-87, 97-119, 131-150, 155-172, 193-215, 225-244, 251-273 and 283-305 218494004424 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 1.1e-40 218494004425 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 218494004426 TM-ABC transporter signature motif; other site 218494004427 8 probable transmembrane helices predicted for SSU0931 by TMHMM2.0 at aa 7-29, 75-97, 106-128, 138-156, 196-213, 241-263, 284-306 and 321-343 218494004428 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 7.4e-41 218494004429 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 218494004430 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494004431 Walker A/P-loop; other site 218494004432 ATP binding site [chemical binding]; other site 218494004433 Q-loop/lid; other site 218494004434 ABC transporter signature motif; other site 218494004435 Walker B; other site 218494004436 D-loop; other site 218494004437 H-loop/switch region; other site 218494004438 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 218494004439 HMMPfam hit to PF00005, ABC transporter related, score 1.6e-17 218494004440 PS00211 ABC transporters family signature. 218494004441 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004442 HMMPfam hit to PF00005, ABC transporter related, score 1.1e-53 218494004443 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004444 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004445 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 218494004446 ligand binding site [chemical binding]; other site 218494004447 HMMPfam hit to PF02608, Basic membrane lipoprotein, score 4e-78 218494004448 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494004449 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 218494004450 active site 218494004451 catalytic motif [active] 218494004452 Zn binding site [ion binding]; other site 218494004453 HMMPfam hit to PF00383, CMP/dCMP deaminase, zinc-binding, score 2.6e-25 218494004454 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 218494004455 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 218494004456 intersubunit interface [polypeptide binding]; other site 218494004457 active site 218494004458 catalytic residue [active] 218494004459 HMMPfam hit to PF01791, Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase, score 1.9e-82 218494004460 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 218494004461 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 218494004462 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 218494004463 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 218494004464 HMMPfam hit to PF07831, Pyrimidine nucleoside phosphorylase, C-terminal, score 3.2e-29 218494004465 HMMPfam hit to PF00591, Glycosyl transferase, family 3, score 6.4e-34 218494004466 PS00647 Thymidine and pyrimidine-nucleoside phosphorylases signature. 218494004467 HMMPfam hit to PF02885, Glycosyl transferase, family 3, score 2e-20 218494004468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218494004469 S-adenosylmethionine binding site [chemical binding]; other site 218494004470 HMMPfam hit to PF05175, Methyltransferase small, score 2.4e-66 218494004471 pantothenate kinase; Provisional; Region: PRK05439 218494004472 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 218494004473 ATP-binding site [chemical binding]; other site 218494004474 CoA-binding site [chemical binding]; other site 218494004475 Mg2+-binding site [ion binding]; other site 218494004476 HMMPfam hit to PF00485, Phosphoribulokinase/uridine kinase, score 7.8e-07 218494004477 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004478 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 218494004479 HMMPfam hit to PF01649, Ribosomal protein S20, score 1.8e-18 218494004480 Transposase IS200 like; Region: Y1_Tnp; cl00848 218494004481 HMMPfam hit to PF01797, Transposase IS200-like, score 1.2e-58 218494004482 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 218494004483 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 218494004484 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494004485 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 218494004486 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218494004487 dimer interface [polypeptide binding]; other site 218494004488 phosphorylation site [posttranslational modification] 218494004489 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218494004490 ATP binding site [chemical binding]; other site 218494004491 Mg2+ binding site [ion binding]; other site 218494004492 G-X-G motif; other site 218494004493 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 5.1e-34 218494004494 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 8.9e-12 218494004495 2 probable transmembrane helices predicted for SSU0944 by TMHMM2.0 at aa 15-37 and 206-228 218494004496 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 218494004497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218494004498 active site 218494004499 phosphorylation site [posttranslational modification] 218494004500 intermolecular recognition site; other site 218494004501 dimerization interface [polypeptide binding]; other site 218494004502 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218494004503 DNA binding site [nucleotide binding] 218494004504 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 2.2e-17 218494004505 HMMPfam hit to PF00072, Response regulator receiver, score 7.5e-30 218494004506 1 probable transmembrane helix predicted for SSU0946 by TMHMM2.0 at aa 13-32 218494004507 Transposase; Region: DEDD_Tnp_IS110; pfam01548 218494004508 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 218494004509 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 218494004510 HMMPfam hit to PF01548, Transposase, IS111A/IS1328/IS1533, score 7.2e-05 218494004511 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 1.2e-20 218494004512 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 218494004513 PhoU domain; Region: PhoU; pfam01895 218494004514 PhoU domain; Region: PhoU; pfam01895 218494004515 HMMPfam hit to PF01895, PhoU, score 2.1e-12 218494004516 HMMPfam hit to PF01895, PhoU, score 3e-29 218494004517 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 218494004518 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 218494004519 Walker A/P-loop; other site 218494004520 ATP binding site [chemical binding]; other site 218494004521 Q-loop/lid; other site 218494004522 ABC transporter signature motif; other site 218494004523 Walker B; other site 218494004524 D-loop; other site 218494004525 H-loop/switch region; other site 218494004526 HMMPfam hit to PF00005, ABC transporter related, score 3e-49 218494004527 PS00211 ABC transporters family signature. 218494004528 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004529 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 218494004530 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 218494004531 Walker A/P-loop; other site 218494004532 ATP binding site [chemical binding]; other site 218494004533 Q-loop/lid; other site 218494004534 ABC transporter signature motif; other site 218494004535 Walker B; other site 218494004536 D-loop; other site 218494004537 H-loop/switch region; other site 218494004538 HMMPfam hit to PF00005, ABC transporter related, score 3.5e-48 218494004539 PS00211 ABC transporters family signature. 218494004540 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004541 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 218494004542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494004543 dimer interface [polypeptide binding]; other site 218494004544 conserved gate region; other site 218494004545 putative PBP binding loops; other site 218494004546 ABC-ATPase subunit interface; other site 218494004547 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.7e-37 218494004548 4 probable transmembrane helices predicted for SSU0951 by TMHMM2.0 at aa 12-34, 66-88, 109-131 and 258-280 218494004549 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218494004550 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 218494004551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494004552 dimer interface [polypeptide binding]; other site 218494004553 conserved gate region; other site 218494004554 putative PBP binding loops; other site 218494004555 ABC-ATPase subunit interface; other site 218494004556 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.3e-24 218494004557 6 probable transmembrane helices predicted for SSU0952 by TMHMM2.0 at aa 25-47, 86-108, 121-143, 153-175, 205-227 and 273-295 218494004558 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218494004559 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 2.5e-07 218494004560 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004561 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494004562 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 218494004563 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218494004564 S-adenosylmethionine binding site [chemical binding]; other site 218494004565 Uncharacterized conserved protein [Function unknown]; Region: COG3270 218494004566 HMMPfam hit to PF01189, Bacterial Fmu (Sun)/eukaryotic nucleolar NOL1/Nop2p, score 4.3e-33 218494004567 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004568 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 218494004569 active site 218494004570 HMMPfam hit to PF00459, Inositol monophosphatase, score 3.5e-46 218494004571 Uncharacterised protein family (UPF0223); Region: UPF0223; cl11484 218494004572 HMMPfam hit to PF05256, Protein of unknown function UPF0223, score 2.1e-49 218494004573 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 218494004574 ArsC family; Region: ArsC; pfam03960 218494004575 putative catalytic residues [active] 218494004576 thiol/disulfide switch; other site 218494004577 HMMPfam hit to PF03960, Arsenate reductase and related, score 1.8e-55 218494004578 Ion channel; Region: Ion_trans_2; cl11596 218494004579 HMMPfam hit to PF07885, Ion transport 2, score 3.9e-24 218494004580 5 probable transmembrane helices predicted for SSU0958 by TMHMM2.0 at aa 27-49, 56-73, 83-105, 136-158 and 191-213 218494004581 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 218494004582 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 218494004583 active site 218494004584 Riboflavin kinase; Region: Flavokinase; cl03312 218494004585 HMMPfam hit to PF01687, Riboflavin kinase, score 2e-47 218494004586 HMMPfam hit to PF06574, FAD synthetase, score 3.5e-60 218494004587 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 218494004588 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 218494004589 RNA binding site [nucleotide binding]; other site 218494004590 active site 218494004591 HMMPfam hit to PF01509, tRNA pseudouridine synthase B, N-terminal, score 1.5e-73 218494004592 Probable pseudogene. CDS contains a frameshift after codon 69. C-terminal region is similar to Streptococcus mutans hypothetical protein SMU.1156C UniProt:Q8DU03 (EMBL:AE014952) (115 aa) fasta scores: E()=6.3e-12, 42.478% id in 113 aa 218494004593 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004594 CDS contains a frameshift and deletion after codon 361. CDS lacks 29 amino acid residues in comparison to orthologues. Similar to Streptococcus pneumoniae hypothetical protein SP0562 UniProt:Q97S51 (EMBL:AE007366) (444 aa) fasta scores: E()=2.1e-94, 62.780% id in 446 aa 218494004595 HMMPfam hit to PF01814, Hemerythrin HHE cation binding region, score 0.0028 218494004596 HMMPfam hit to PF01814, Hemerythrin HHE cation binding region, score 0.0064 218494004597 HMMPfam hit to PF04282, Protein of unknown function DUF438, score 3.8e-43 218494004598 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 218494004599 HMMPfam hit to PF08984, Region of unknown function DUF1858, score 1.5e-32 218494004600 Transposase; Region: HTH_Tnp_IS630; pfam01710 218494004601 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 218494004602 HMMPfam hit to PF01710, Transposase, Synechocystis PCC 6803, score 6.5e-16 218494004603 Predicted helix-turn-helix motif with score 2164.000, SD 6.56 at aa 19-40, sequence GSITEASAIFQVSRNTIYQWLK 218494004604 Integrase core domain; Region: rve; cl01316 218494004605 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 2.9e-05 218494004606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 218494004607 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 218494004608 2 probable transmembrane helices predicted for SSU0970 by TMHMM2.0 at aa 34-52 and 62-81 218494004609 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 218494004610 hydrophobic ligand binding site; other site 218494004611 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218494004612 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 218494004613 active site 218494004614 motif I; other site 218494004615 motif II; other site 218494004616 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 218494004617 PS01228 Hypothetical cof family signature 1. 218494004618 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 5.1e-83 218494004619 PS01229 Hypothetical cof family signature 2. 218494004620 peptidase T; Region: peptidase-T; TIGR01882 218494004621 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 218494004622 metal binding site [ion binding]; metal-binding site 218494004623 dimer interface [polypeptide binding]; other site 218494004624 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 218494004625 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 218494004626 HMMPfam hit to PF01546, Peptidase M20, score 7.9e-08 218494004627 HMMPfam hit to PF07687, Peptidase M20, dimerisation, score 2.2e-20 218494004628 3 probable transmembrane helices predicted for SSU0974 by TMHMM2.0 at aa 15-37, 68-90 and 94-116 218494004629 Membrane transport protein; Region: Mem_trans; cl09117 218494004630 10 probable transmembrane helices predicted for SSU0975 by TMHMM2.0 at aa 6-23, 36-58, 63-85, 92-114, 124-146, 166-185, 189-211, 223-245, 250-272 and 284-303 218494004631 HMMPfam hit to PF03547, Auxin efflux carrier, score 3.1e-06 218494004632 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494004633 HMMPfam hit to PF03551, Transcriptional regulator PadR-like, score 2.6e-24 218494004634 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 218494004635 HMMPfam hit to PF08006, Protein of unknown function DUF1700, score 0.0016 218494004636 Protein of unknown function (DUF1700); Region: DUF1700; cl01933 218494004637 HMMPfam hit to PF08006, Protein of unknown function DUF1700, score 3.1e-09 218494004638 3 probable transmembrane helices predicted for SSU0978 by TMHMM2.0 at aa 76-98, 103-125 and 138-160 218494004639 1 probable transmembrane helix predicted for SSU0979 by TMHMM2.0 at aa 12-34 218494004640 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 218494004641 4 probable transmembrane helices predicted for SSU0980 by TMHMM2.0 at aa 7-29, 55-72, 79-96 and 100-118 218494004642 HMMPfam hit to PF06993, Protein of unknown function DUF1304, score 9.3e-62 218494004643 Transcriptional regulators [Transcription]; Region: MarR; COG1846 218494004644 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494004645 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 2e-18 218494004646 Predicted helix-turn-helix motif with score 1230.000, SD 3.38 at aa 2-23, sequence QEMEDLLYRLKVTDETISNLFE 218494004647 Uncharacterized conserved protein [Function unknown]; Region: COG2966 218494004648 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 218494004649 HMMPfam hit to PF06738, Protein of unknown function DUF1212, score 8.8e-63 218494004650 4 probable transmembrane helices predicted for SSU0982 by TMHMM2.0 at aa 125-147, 162-184, 196-215 and 230-251 218494004651 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 218494004652 5 probable transmembrane helices predicted for SSU0983 by TMHMM2.0 at aa 5-24, 31-50, 54-76, 81-103 and 118-140 218494004653 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 218494004654 Cation efflux family; Region: Cation_efflux; cl00316 218494004655 5 probable transmembrane helices predicted for SSU0984 by TMHMM2.0 at aa 13-35, 45-62, 83-100, 115-137 and 170-192 218494004656 HMMPfam hit to PF01545, Cation efflux protein, score 8.2e-97 218494004657 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 218494004658 12 probable transmembrane helices predicted for SSU0985 by TMHMM2.0 at aa 2-19, 24-46, 59-81, 107-129, 142-164, 184-206, 238-255, 260-282, 303-325, 340-362, 375-397 and 412-434 218494004659 HMMPfam hit to PF03600, Divalent ion symporter, score 3.8e-30 218494004660 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 218494004661 catalytic center binding site [active] 218494004662 ATP binding site [chemical binding]; other site 218494004663 HMMPfam hit to PF01288, 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK, score 1.3e-57 218494004664 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 218494004665 homooctamer interface [polypeptide binding]; other site 218494004666 active site 218494004667 HMMPfam hit to PF02152, Dihydroneopterin aldolase, score 1.4e-42 218494004668 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 218494004669 dihydropteroate synthase; Region: DHPS; TIGR01496 218494004670 substrate binding pocket [chemical binding]; other site 218494004671 dimer interface [polypeptide binding]; other site 218494004672 inhibitor binding site; inhibition site 218494004673 HMMPfam hit to PF00809, Dihydropteroate synthase, DHPS, score 6.4e-100 218494004674 PS00793 Dihydropteroate synthase signature 2. 218494004675 PS00792 Dihydropteroate synthase signature 1. 218494004676 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 218494004677 homodecamer interface [polypeptide binding]; other site 218494004678 GTP cyclohydrolase I; Provisional; Region: PLN03044 218494004679 active site 218494004680 putative catalytic site residues [active] 218494004681 zinc binding site [ion binding]; other site 218494004682 GTP-CH-I/GFRP interaction surface; other site 218494004683 HMMPfam hit to PF01227, GTP cyclohydrolase I, score 1.4e-53 218494004684 PS00860 GTP cyclohydrolase I signature 2. 218494004685 PS00859 GTP cyclohydrolase I signature 1. 218494004686 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 218494004687 putative active site [active] 218494004688 nucleotide binding site [chemical binding]; other site 218494004689 nudix motif; other site 218494004690 putative metal binding site [ion binding]; other site 218494004691 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 1.2e-27 218494004692 PS00893 mutT domain signature. 218494004693 2 probable transmembrane helices predicted for SSU0991 by TMHMM2.0 at aa 40-62 and 75-97 218494004694 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 218494004695 putative metal binding residues [ion binding]; other site 218494004696 signature motif; other site 218494004697 dimer interface [polypeptide binding]; other site 218494004698 polyP binding site; other site 218494004699 active site 218494004700 substrate binding site [chemical binding]; other site 218494004701 acceptor-phosphate pocket; other site 218494004702 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 218494004703 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 218494004704 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 218494004705 putative tRNA-binding site [nucleotide binding]; other site 218494004706 B3/4 domain; Region: B3_4; cl11458 218494004707 tRNA synthetase B5 domain; Region: B5; cl08394 218494004708 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 218494004709 dimer interface [polypeptide binding]; other site 218494004710 motif 1; other site 218494004711 motif 3; other site 218494004712 motif 2; other site 218494004713 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 218494004714 HMMPfam hit to PF03147, Phenylalanyl-tRNA synthetase, beta subunit, ferrodoxin-fold anticodon-binding, score 5.4e-29 218494004715 HMMPfam hit to PF03484, tRNA synthetase, B5, score 1.8e-29 218494004716 HMMPfam hit to PF03483, B3/4, score 2.7e-98 218494004717 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004718 HMMPfam hit to PF01588, tRNA-binding region, score 1.1e-23 218494004719 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 218494004720 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218494004721 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 218494004722 Coenzyme A binding pocket [chemical binding]; other site 218494004723 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 2.3e-18 218494004724 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 218494004725 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 218494004726 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 218494004727 dimer interface [polypeptide binding]; other site 218494004728 motif 1; other site 218494004729 active site 218494004730 motif 2; other site 218494004731 motif 3; other site 218494004732 HMMPfam hit to PF01409, Phenylalanyl-tRNA synthetase, class IIc, score 3.9e-173 218494004733 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 218494004734 HMMPfam hit to PF02912, Phenylalanyl-tRNA synthetase, class II, N-terminal, score 1.8e-27 218494004735 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 218494004736 HMMPfam hit to PF00933, Glycoside hydrolase, family 3, N-terminal, score 1.9e-15 218494004737 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 218494004738 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 218494004739 HMMPfam hit to PF00933, Glycoside hydrolase, family 3, N-terminal, score 2.7e-27 218494004740 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218494004741 motif II; other site 218494004742 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 218494004743 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 218494004744 putative NAD(P) binding site [chemical binding]; other site 218494004745 active site 218494004746 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 9.3e-14 218494004747 PS00061 Short-chain dehydrogenases/reductases family signature. 218494004748 mannonate dehydratase; Provisional; Region: PRK03906 218494004749 mannonate dehydratase; Region: uxuA; TIGR00695 218494004750 HMMPfam hit to PF03786, Mannonate dehydratase, score 6.6e-190 218494004751 Glucuronate isomerase; Region: UxaC; cl00829 218494004752 HMMPfam hit to PF02614, Glucuronate isomerase, score 1.3e-171 218494004753 Entner-Doudoroff aldolase; Region: eda; TIGR01182 218494004754 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 218494004755 active site 218494004756 intersubunit interface [polypeptide binding]; other site 218494004757 catalytic residue [active] 218494004758 HMMPfam hit to PF01081, KDPG and KHG aldolase, score 1.6e-31 218494004759 Transcriptional regulators [Transcription]; Region: FadR; COG2186 218494004760 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218494004761 DNA-binding site [nucleotide binding]; DNA binding site 218494004762 FCD domain; Region: FCD; cl11656 218494004763 HMMPfam hit to PF07729, GntR, C-terminal, score 5.8e-26 218494004764 HMMPfam hit to PF00392, Bacterial regulatory protein GntR, HTH, score 2e-21 218494004765 PS00043 Bacterial regulatory proteins, gntR family signature. 218494004766 Predicted helix-turn-helix motif with score 1103.000, SD 2.94 at aa 29-50, sequence PNEYELAQDLEVGRSTVREAVR 218494004767 beta-D-glucuronidase; Provisional; Region: PRK10150 218494004768 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 218494004769 domain; Region: Glyco_hydro_2; pfam00703 218494004770 HMMPfam hit to PF02836, Glycoside hydrolase family 2, TIM barrel, score 6.5e-94 218494004771 PS00719 Glycosyl hydrolases family 2 signature 1. 218494004772 HMMPfam hit to PF00703, Glycoside hydrolase family 2, immunoglobulin-like beta-sandwich, score 1.1e-14 218494004773 HMMPfam hit to PF02837, Glycoside hydrolase family 2, carbohydrate-binding, score 7.7e-38 218494004774 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 218494004775 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 218494004776 substrate binding site [chemical binding]; other site 218494004777 ATP binding site [chemical binding]; other site 218494004778 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 0.00038 218494004779 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 8.6e-17 218494004780 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 218494004781 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 218494004782 11 probable transmembrane helices predicted for SSU1008 by TMHMM2.0 at aa 34-56, 91-113, 117-134, 155-177, 192-214, 247-269, 289-306, 313-335, 350-372, 403-422 and 437-459 218494004783 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 218494004784 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 218494004785 HMMPfam hit to PF01223, DNA/RNA non-specific endonuclease, score 2.1e-13 218494004786 PS01070 DNA/RNA non-specific endonucleases active site. 218494004787 1 probable transmembrane helix predicted for SSU1009 by TMHMM2.0 at aa 13-30 218494004788 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 218494004789 1 probable transmembrane helix predicted for SSU1010 by TMHMM2.0 at aa 13-35 218494004790 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 218494004791 hinge; other site 218494004792 active site 218494004793 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 218494004794 HMMPfam hit to PF00275, 3-phosphoshikimate 1-carboxyvinyltransferase, score 3.1e-132 218494004795 2 probable transmembrane helices predicted for SSU1012 by TMHMM2.0 at aa 4-23 and 44-66 218494004796 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 218494004797 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 218494004798 HMMPfam hit to PF00401, ATPase, F1 complex, delta/epsilon subunit, score 0.00015 218494004799 HMMPfam hit to PF02823, ATPase, F1 complex, delta/epsilon subunit, score 6.5e-27 218494004800 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 218494004801 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 218494004802 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 218494004803 alpha subunit interaction interface [polypeptide binding]; other site 218494004804 Walker A motif; other site 218494004805 ATP binding site [chemical binding]; other site 218494004806 Walker B motif; other site 218494004807 inhibitor binding site; inhibition site 218494004808 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 218494004809 HMMPfam hit to PF00306, ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal, score 3e-51 218494004810 HMMPfam hit to PF00006, ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding, score 1.7e-100 218494004811 PS00152 ATP synthase alpha and beta subunits signature. 218494004812 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004813 HMMPfam hit to PF02874, ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal, score 4.6e-28 218494004814 ATP synthase; Region: ATP-synt; cl00365 218494004815 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 218494004816 HMMPfam hit to PF00231, ATPase, F1 complex, gamma subunit, score 3.9e-126 218494004817 PS00153 ATP synthase gamma subunit signature. 218494004818 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 218494004819 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 218494004820 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 218494004821 beta subunit interaction interface [polypeptide binding]; other site 218494004822 Walker A motif; other site 218494004823 ATP binding site [chemical binding]; other site 218494004824 Walker B motif; other site 218494004825 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 218494004826 HMMPfam hit to PF00306, ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal, score 3e-37 218494004827 HMMPfam hit to PF00006, ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding, score 7e-118 218494004828 PS00152 ATP synthase alpha and beta subunits signature. 218494004829 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004830 HMMPfam hit to PF02874, ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal, score 1.3e-16 218494004831 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl15360 218494004832 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 218494004833 HMMPfam hit to PF00213, ATPase, F1 complex, OSCP/delta subunit, score 2.5e-18 218494004834 Plant ATP synthase F0; Region: YMF19; cl07975 218494004835 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 218494004836 HMMPfam hit to PF00430, ATPase, F0 complex, subunit B/B', bacterial and chloroplast, score 1e-25 218494004837 1 probable transmembrane helix predicted for SSU1018 by TMHMM2.0 at aa 13-35 218494004838 ATP synthase A chain; Region: ATP-synt_A; cl00413 218494004839 HMMPfam hit to PF00119, ATPase, F0 complex, subunit A, score 1.1e-48 218494004840 5 probable transmembrane helices predicted for SSU1019 by TMHMM2.0 at aa 15-37, 75-97, 112-134, 167-189 and 204-226 218494004841 PS00449 ATP synthase a subunit signature. 218494004842 ATP synthase subunit C; Region: ATP-synt_C; cl00466 218494004843 2 probable transmembrane helices predicted for SSU1020 by TMHMM2.0 at aa 5-27 and 40-62 218494004844 HMMPfam hit to PF00137, ATPase, F0/V0 complex, subunit C, score 3e-10 218494004845 PS00605 ATP synthase c subunit signature. 218494004846 putative lipid kinase; Reviewed; Region: PRK13055 218494004847 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 218494004848 HMMPfam hit to PF00781, Diacylglycerol kinase, catalytic region, score 1.9e-43 218494004849 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 218494004850 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 218494004851 nucleotide binding pocket [chemical binding]; other site 218494004852 K-X-D-G motif; other site 218494004853 catalytic site [active] 218494004854 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 218494004855 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 218494004856 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 218494004857 Dimer interface [polypeptide binding]; other site 218494004858 BRCT sequence motif; other site 218494004859 HMMPfam hit to PF00533, BRCT, score 1.3e-13 218494004860 HMMPfam hit to PF03119, Zinc-finger, NAD-dependent DNA ligase C4-type, score 4.7e-11 218494004861 HMMPfam hit to PF03120, NAD-dependent DNA ligase, OB-fold, score 1.3e-46 218494004862 PS01056 NAD-dependent DNA ligase signature 2. 218494004863 HMMPfam hit to PF01653, NAD-dependent DNA ligase, adenylation, score 4.4e-154 218494004864 PS01055 NAD-dependent DNA ligase signature 1. 218494004865 Predicted permease; Region: DUF318; cl00487 218494004866 HMMPfam hit to PF03773, Protein of unknown function DUF318, transmembrane, score 2.7e-111 218494004867 8 probable transmembrane helices predicted for SSU1023 by TMHMM2.0 at aa 17-39, 59-81, 94-113, 123-145, 189-211, 215-232, 239-258 and 278-300 218494004868 PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. 218494004869 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 218494004870 HMMPfam hit to PF09323, Protein of unknown function DUF1980, score 3.2e-101 218494004871 3 probable transmembrane helices predicted for SSU1024 by TMHMM2.0 at aa 2-19, 32-54 and 67-89 218494004872 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 218494004873 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 218494004874 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 218494004875 HMMPfam hit to PF00479, Glucose-6-phosphate dehydrogenase, score 7.4e-104 218494004876 PS00069 Glucose-6-phosphate dehydrogenase active site. 218494004877 HMMPfam hit to PF02781, Glucose-6-phosphate dehydrogenase, score 3.5e-112 218494004878 A new structural DNA glycosylase; Region: AlkD_like; cd06561 218494004879 active site 218494004880 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 218494004881 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 218494004882 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 4.7e-05 218494004883 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 218494004884 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 218494004885 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 218494004886 P loop; other site 218494004887 GTP binding site [chemical binding]; other site 218494004888 HMMPfam hit to PF00448, Signal recognition particle, SRP54 subunit, GTPase, score 6e-110 218494004889 PS00300 SRP54-type proteins GTP-binding domain signature. 218494004890 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004891 HMMPfam hit to PF02881, Signal recognition particle, SRP54 subunit, helical bundle, score 7.4e-14 218494004892 sugar phosphate phosphatase; Provisional; Region: PRK10513 218494004893 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218494004894 active site 218494004895 motif I; other site 218494004896 motif II; other site 218494004897 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 218494004898 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 2.6e-80 218494004899 PS01228 Hypothetical cof family signature 1. 218494004900 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218494004901 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 218494004902 active site 218494004903 motif I; other site 218494004904 motif II; other site 218494004905 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 218494004906 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 5e-69 218494004907 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 218494004908 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 218494004909 Walker A/P-loop; other site 218494004910 ATP binding site [chemical binding]; other site 218494004911 Q-loop/lid; other site 218494004912 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 218494004913 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 218494004914 ABC transporter signature motif; other site 218494004915 Walker B; other site 218494004916 D-loop; other site 218494004917 H-loop/switch region; other site 218494004918 HMMPfam hit to PF02463, SMC protein, N-terminal, score 2.9e-109 218494004919 HMMPfam hit to PF06470, SMCs flexible hinge, score 7.9e-33 218494004920 Predicted helix-turn-helix motif with score 1022.000, SD 2.67 at aa 330-351, sequence TRREQLAEQIEQKQETLAQLDS 218494004921 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004922 ribonuclease III; Reviewed; Region: rnc; PRK00102 218494004923 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 218494004924 dimerization interface [polypeptide binding]; other site 218494004925 active site 218494004926 metal binding site [ion binding]; metal-binding site 218494004927 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 218494004928 dsRNA binding site [nucleotide binding]; other site 218494004929 HMMPfam hit to PF00035, Double-stranded RNA binding, score 2.4e-18 218494004930 HMMPfam hit to PF00636, Ribonuclease III, score 7.3e-47 218494004931 PS00517 Ribonuclease III family signature. 218494004932 9 probable transmembrane helices predicted for SSU1033 by TMHMM2.0 at aa 7-29, 44-63, 84-106, 121-140, 147-169, 184-206, 245-262, 277-296 and 308-326 218494004933 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494004934 H+ Antiporter protein; Region: 2A0121; TIGR00900 218494004935 10 probable transmembrane helices predicted for SSU1035 by TMHMM2.0 at aa 9-31, 44-66, 87-109, 149-166, 171-193, 237-259, 266-288, 320-342, 363-385 and 390-412 218494004936 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 3.9e-10 218494004937 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 218494004938 Integrase core domain; Region: rve; cl01316 218494004939 HMMPfam hit to PF00665, Integrase, catalytic core, score 9.1e-14 218494004940 Predicted helix-turn-helix motif with score 1377.000, SD 3.88 at aa 22-43, sequence KPFSAIAAKLGKDPSTISKEVR 218494004941 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 218494004942 hypothetical protein; Provisional; Region: PRK13663 218494004943 HMMPfam hit to PF08903, Protein of unknown function DUF1846, score 0 218494004944 PS00017 ATP/GTP-binding site motif A (P-loop). 218494004945 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 218494004946 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 218494004947 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 218494004948 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 218494004949 HMMPfam hit to PF02896, PEP-utilizing enzyme, score 5.9e-197 218494004950 PS00742 PEP-utilizing enzymes signature 2. 218494004951 HMMPfam hit to PF00391, PEP-utilising enzyme, mobile region, score 3.4e-40 218494004952 PS00370 PEP-utilizing enzymes phosphorylation site signature. 218494004953 HMMPfam hit to PF05524, Phosphotransferase system, PEP-utilising enzyme, N-terminal, score 2.6e-60 218494004954 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 218494004955 dimerization domain swap beta strand [polypeptide binding]; other site 218494004956 regulatory protein interface [polypeptide binding]; other site 218494004957 active site 218494004958 regulatory phosphorylation site [posttranslational modification]; other site 218494004959 HMMPfam hit to PF00381, Phosphotransferase system, phosphocarrier HPr protein, score 2.3e-51 218494004960 PS00589 PTS HPR component serine phosphorylation site signature. 218494004961 PS00369 PTS HPR component histidine phosphorylation site signature. 218494004962 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 218494004963 isocitrate dehydrogenase; Validated; Region: PRK06451 218494004964 HMMPfam hit to PF00180, Isocitrate/isopropylmalate dehydrogenase, score 4.1e-137 218494004965 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 218494004966 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 218494004967 dimer interface [polypeptide binding]; other site 218494004968 Citrate synthase; Region: Citrate_synt; pfam00285 218494004969 active site 218494004970 citrylCoA binding site [chemical binding]; other site 218494004971 oxalacetate/citrate binding site [chemical binding]; other site 218494004972 coenzyme A binding site [chemical binding]; other site 218494004973 catalytic triad [active] 218494004974 HMMPfam hit to PF00285, Citrate synthase, score 4.9e-140 218494004975 PS00480 Citrate synthase signature. 218494004976 aconitate hydratase; Validated; Region: PRK09277 218494004977 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 218494004978 substrate binding site [chemical binding]; other site 218494004979 ligand binding site [chemical binding]; other site 218494004980 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 218494004981 substrate binding site [chemical binding]; other site 218494004982 HMMPfam hit to PF00694, Aconitase A/isopropylmalate dehydratase small subunit, swivel, score 9.7e-52 218494004983 HMMPfam hit to PF00330, Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, score 1.1e-179 218494004984 PS01244 Aconitase family signature 2. 218494004985 PS00450 Aconitase family signature 1. 218494004986 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 218494004987 catalytic residues [active] 218494004988 HMMPfam hit to PF00462, Glutaredoxin, score 7.6e-15 218494004989 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 218494004990 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 218494004991 Class I ribonucleotide reductase; Region: RNR_I; cd01679 218494004992 active site 218494004993 dimer interface [polypeptide binding]; other site 218494004994 catalytic residues [active] 218494004995 effector binding site; other site 218494004996 R2 peptide binding site; other site 218494004997 HMMPfam hit to PF08343, Ribonucleotide reductase N-terminal, score 7.2e-41 218494004998 HMMPfam hit to PF00317, Ribonucleotide reductase large subunit, N-terminal, score 7.9e-26 218494004999 HMMPfam hit to PF02867, Ribonucleotide reductase large subunit, C-terminal, score 4.8e-133 218494005000 PS00089 Ribonucleotide reductase large subunit signature. 218494005001 rod shape-determining protein MreC; Provisional; Region: PRK13922 218494005002 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 218494005003 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 218494005004 dimer interface [polypeptide binding]; other site 218494005005 putative radical transfer pathway; other site 218494005006 diiron center [ion binding]; other site 218494005007 tyrosyl radical; other site 218494005008 HMMPfam hit to PF00268, Ribonucleotide reductase, score 2e-65 218494005009 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218494005010 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218494005011 DNA binding site [nucleotide binding] 218494005012 domain linker motif; other site 218494005013 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 218494005014 putative dimerization interface [polypeptide binding]; other site 218494005015 putative ligand binding site [chemical binding]; other site 218494005016 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 4.4e-13 218494005017 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 9.7e-08 218494005018 Predicted helix-turn-helix motif with score 1691.000, SD 4.95 at aa 5-26, sequence FTIKDIAELAQTSKTTVSFYLN 218494005019 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 218494005020 HMMPfam hit to PF07940, Heparinase II/III-like, score 8.5e-33 218494005021 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 6.6e-05 218494005022 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494005023 HMMPfam hit to PF02884, Polysaccharide lyase family 8, C-terminal, score 7.9e-14 218494005024 HMMPfam hit to PF02278, Polysaccharide lyase family 8, central, score 2.3e-65 218494005025 HMMPfam hit to PF08124, Polysaccharide lyase 8, N-terminal alpha-helical, score 2.6e-60 218494005026 HMMPfam hit to PF08124, Polysaccharide lyase 8, N-terminal alpha-helical, score 8.5e-61 218494005027 HMMPfam hit to PF04650, YSIRK Gram-positive signal peptide, score 4.5e-10 218494005028 Preprotein translocase subunit; Region: YajC; cl00806 218494005029 1 probable transmembrane helix predicted for SSU1054 by TMHMM2.0 at aa 5-27 218494005030 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 218494005031 HMMPfam hit to PF03613, Phosphotransferase system, mannose/fructose/sorbose family IID component, score 1.1e-125 218494005032 5 probable transmembrane helices predicted for SSU1055 by TMHMM2.0 at aa 110-132, 136-158, 179-201, 226-243 and 248-270 218494005033 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 218494005034 HMMPfam hit to PF03609, Phosphotransferase system, sorbose-specific IIC subunit, score 4.6e-93 218494005035 6 probable transmembrane helices predicted for SSU1056 by TMHMM2.0 at aa 5-27, 32-54, 59-81, 141-163, 178-200 and 207-229 218494005036 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 218494005037 active site 218494005038 phosphorylation site [posttranslational modification] 218494005039 HMMPfam hit to PF03830, Phosphotransferase system, sorbose subfamily IIB component, score 1.1e-76 218494005040 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 218494005041 HMMPfam hit to PF07470, Glycosyl hydrolase, family 88, score 1.7e-95 218494005042 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 218494005043 active pocket/dimerization site; other site 218494005044 active site 218494005045 phosphorylation site [posttranslational modification] 218494005046 HMMPfam hit to PF03610, Phosphotransferase system, fructose subfamily IIA component, score 1.4e-32 218494005047 Entner-Doudoroff aldolase; Region: eda; TIGR01182 218494005048 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 218494005049 active site 218494005050 intersubunit interface [polypeptide binding]; other site 218494005051 catalytic residue [active] 218494005052 HMMPfam hit to PF01081, KDPG and KHG aldolase, score 7.4e-25 218494005053 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 218494005054 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 218494005055 substrate binding site [chemical binding]; other site 218494005056 ATP binding site [chemical binding]; other site 218494005057 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 1.3e-05 218494005058 HMMPfam hit to PF00294, Carbohydrate/purine kinase, score 3.8e-16 218494005059 hypothetical protein; Provisional; Region: PRK09273 218494005060 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 218494005061 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 218494005062 HMMPfam hit to PF02502, Ribose/galactose isomerase, score 8.7e-40 218494005063 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 218494005064 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 218494005065 NADP binding site [chemical binding]; other site 218494005066 homodimer interface [polypeptide binding]; other site 218494005067 active site 218494005068 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 2.3e-29 218494005069 PS00061 Short-chain dehydrogenases/reductases family signature. 218494005070 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 218494005071 Transposase; Region: DEDD_Tnp_IS110; pfam01548 218494005072 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 218494005073 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 1.4e-17 218494005074 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 218494005075 7 probable transmembrane helices predicted for SSU1066 by TMHMM2.0 at aa 9-31, 46-68, 81-103, 123-145, 158-177, 181-198 and 205-223 218494005076 HMMPfam hit to PF02517, Abortive infection protein, score 4.7e-20 218494005077 7 probable transmembrane helices predicted for SSU1068 by TMHMM2.0 at aa 16-38, 48-70, 82-104, 119-141, 154-173, 178-200 and 205-227 218494005078 HMMPfam hit to PF02517, Abortive infection protein, score 7.7e-14 218494005079 2 probable transmembrane helices predicted for SSU1069 by TMHMM2.0 at aa 12-34 and 44-66 218494005080 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 218494005081 6 probable transmembrane helices predicted for SSU1070 by TMHMM2.0 at aa 20-42, 52-71, 107-129, 133-155, 198-220 and 225-242 218494005082 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218494005083 non-specific DNA binding site [nucleotide binding]; other site 218494005084 salt bridge; other site 218494005085 sequence-specific DNA binding site [nucleotide binding]; other site 218494005086 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 2.7e-13 218494005087 Predicted helix-turn-helix motif with score 2054.000, SD 6.18 at aa 18-39, sequence LNQTELAKLAEVSRQTISLIER 218494005088 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 218494005089 4 probable transmembrane helices predicted for SSU1072 by TMHMM2.0 at aa 22-44, 59-81, 116-138 and 143-165 218494005090 2 probable transmembrane helices predicted for SSU1073 by TMHMM2.0 at aa 12-34 and 44-61 218494005091 1 probable transmembrane helix predicted for SSU1074 by TMHMM2.0 at aa 21-43 218494005092 1 probable transmembrane helix predicted for SSU1075 by TMHMM2.0 at aa 10-27 218494005093 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 218494005094 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 218494005095 motif 1; other site 218494005096 active site 218494005097 motif 2; other site 218494005098 motif 3; other site 218494005099 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 218494005100 DHHA1 domain; Region: DHHA1; pfam02272 218494005101 HMMPfam hit to PF02272, Phosphoesterase, DHHA1, score 1.7e-13 218494005102 HMMPfam hit to PF07973, Threonyl/alanyl tRNA synthetase, SAD, score 8.9e-23 218494005103 HMMPfam hit to PF01411, Alanyl-tRNA synthetase, class IIc, score 1.8e-242 218494005104 Predicted helix-turn-helix motif with score 995.000, SD 2.58 at aa 311-332, sequence RRASMHGQRLGITEPFLYKLVE 218494005105 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218494005106 Scramblase; Region: Scramblase; cl02043 218494005107 HMMPfam hit to PF04525, Protein of unknown function DUF567, score 8.9e-10 218494005108 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 218494005109 HMMPfam hit to PF00639, Peptidyl-prolyl cis-trans isomerase, PpiC-type, score 4.2e-05 218494005110 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494005111 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 218494005112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218494005113 S-adenosylmethionine binding site [chemical binding]; other site 218494005114 HMMPfam hit to PF08241, Methyltransferase type 11, score 1.4e-09 218494005115 1 probable transmembrane helix predicted for SSU1081 by TMHMM2.0 at aa 20-40 218494005116 oligoendopeptidase F; Region: pepF; TIGR00181 218494005117 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 218494005118 active site 218494005119 Zn binding site [ion binding]; other site 218494005120 HMMPfam hit to PF01432, Peptidase M3A and M3B, thimet/oligopeptidase F, score 1.6e-149 218494005121 HMMPfam hit to PF08439, Peptidase M3B, oligopeptidase F, N-terminal, score 6.2e-22 218494005122 Competence protein CoiA-like family; Region: CoiA; cl11541 218494005123 HMMPfam hit to PF06054, Competence CoiA-like, score 7.6e-109 218494005124 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 218494005125 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 218494005126 active site 218494005127 HIGH motif; other site 218494005128 KMSKS motif; other site 218494005129 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 218494005130 tRNA binding surface [nucleotide binding]; other site 218494005131 anticodon binding site; other site 218494005132 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 218494005133 dimer interface [polypeptide binding]; other site 218494005134 putative tRNA-binding site [nucleotide binding]; other site 218494005135 HMMPfam hit to PF01588, tRNA-binding region, score 6.6e-41 218494005136 HMMPfam hit to PF09334, Aminoacyl-tRNA synthetase, class I (M), score 1.4e-198 218494005137 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 218494005138 6 probable transmembrane helices predicted for SSU1085 by TMHMM2.0 at aa 7-26, 30-47, 54-76, 96-118, 125-147 and 171-193 218494005139 HMMPfam hit to PF07099, Protein of unknown function DUF1361, score 4.9e-61 218494005140 NeuB family; Region: NeuB; cl00496 218494005141 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 218494005142 HMMPfam hit to PF00793, DAHP synthetase I/KDSA, score 3.7e-41 218494005143 NeuB family; Region: NeuB; cl00496 218494005144 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 218494005145 HMMPfam hit to PF00793, DAHP synthetase I/KDSA, score 4.9e-36 218494005146 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 218494005147 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 218494005148 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 218494005149 shikimate binding site; other site 218494005150 NAD(P) binding site [chemical binding]; other site 218494005151 HMMPfam hit to PF08501, Shikimate dehydrogenase substrate binding, N-terminal, score 7.4e-39 218494005152 HMMPfam hit to PF01488, Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase, score 8.3e-07 218494005153 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 218494005154 active site 218494005155 dimer interface [polypeptide binding]; other site 218494005156 metal binding site [ion binding]; metal-binding site 218494005157 HMMPfam hit to PF01761, 3-dehydroquinate synthase AroB, score 1.3e-159 218494005158 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 218494005159 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494005160 Walker A/P-loop; other site 218494005161 ATP binding site [chemical binding]; other site 218494005162 Q-loop/lid; other site 218494005163 ABC transporter signature motif; other site 218494005164 Walker B; other site 218494005165 D-loop; other site 218494005166 H-loop/switch region; other site 218494005167 HMMPfam hit to PF00005, ABC transporter related, score 2.9e-38 218494005168 PS00017 ATP/GTP-binding site motif A (P-loop). 218494005169 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 218494005170 TM-ABC transporter signature motif; other site 218494005171 8 probable transmembrane helices predicted for SSU1091 by TMHMM2.0 at aa 12-34, 54-76, 83-105, 131-153, 181-199, 209-228, 233-255 and 265-282 218494005172 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 7.9e-21 218494005173 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 218494005174 zinc binding site [ion binding]; other site 218494005175 putative ligand binding site [chemical binding]; other site 218494005176 HMMPfam hit to PF04392, ABC transporter substrate binding protein, score 5.6e-84 218494005177 HMMPfam hit to PF06004, Protein of unknown function DUF903, bacterial, score 3.9e-05 218494005178 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494005179 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 218494005180 zinc binding site [ion binding]; other site 218494005181 putative ligand binding site [chemical binding]; other site 218494005182 HMMPfam hit to PF04392, ABC transporter substrate binding protein, score 1.5e-71 218494005183 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494005184 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 218494005185 HMMPfam hit to PF01791, Deoxyribose-phosphate aldolase/phospho-2-dehydro-3-deoxyheptonate aldolase, score 4e-77 218494005186 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 218494005187 active site 218494005188 dimer interface [polypeptide binding]; other site 218494005189 HMMPfam hit to PF01979, Amidohydrolase 1, score 1.9e-08 218494005190 Protein of unknown function (DUF964); Region: DUF964; cl01483 218494005191 HMMPfam hit to PF06133, Protein of unknown function DUF964, score 2.6e-46 218494005192 prephenate dehydrogenase; Validated; Region: PRK06545 218494005193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494005194 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 218494005195 HMMPfam hit to PF02153, Prephenate dehydrogenase, score 2.4e-106 218494005196 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 218494005197 Tetramer interface [polypeptide binding]; other site 218494005198 active site 218494005199 FMN-binding site [chemical binding]; other site 218494005200 HMMPfam hit to PF01264, Chorismate synthase, score 4.2e-166 218494005201 PS00788 Chorismate synthase signature 2. 218494005202 PS00017 ATP/GTP-binding site motif A (P-loop). 218494005203 PS00787 Chorismate synthase signature 1. 218494005204 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 218494005205 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 218494005206 active site 218494005207 catalytic residue [active] 218494005208 dimer interface [polypeptide binding]; other site 218494005209 HMMPfam hit to PF01487, Dehydroquinase class I, score 8.8e-36 218494005210 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 218494005211 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 218494005212 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 218494005213 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 218494005214 Sulfatase; Region: Sulfatase; cl10460 218494005215 5 probable transmembrane helices predicted for SSU1102 by TMHMM2.0 at aa 16-35, 45-67, 74-96, 128-150 and 163-182 218494005216 HMMPfam hit to PF00884, Sulphatase, score 6.9e-32 218494005217 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 218494005218 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 218494005219 Protein of unknown function DUF2625; Region: DUF2625; cl08177 218494005220 PS00063 Aldo/keto reductase family active site signature. 218494005221 HMMPfam hit to PF04270, Streptococcal histidine triad, score 0.19 218494005222 HMMPfam hit to PF04270, Streptococcal histidine triad, score 9.3e-06 218494005223 HMMPfam hit to PF04270, Streptococcal histidine triad, score 7.3 218494005224 1 probable transmembrane helix predicted for SSU1103 by TMHMM2.0 at aa 7-29 218494005225 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 218494005226 23S rRNA binding site [nucleotide binding]; other site 218494005227 L21 binding site [polypeptide binding]; other site 218494005228 L13 binding site [polypeptide binding]; other site 218494005229 HMMPfam hit to PF00453, Ribosomal protein L20, score 1.1e-65 218494005230 Predicted helix-turn-helix motif with score 1159.000, SD 3.13 at aa 63-84, sequence TRINAAARMNGLSYSQLMHGLK 218494005231 PS00937 Ribosomal protein L20 signature. 218494005232 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 218494005233 HMMPfam hit to PF01632, Ribosomal protein L35, score 1.3e-21 218494005234 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 218494005235 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 218494005236 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 218494005237 HMMPfam hit to PF00707, Initiation factor 3, score 1.8e-45 218494005238 HMMPfam hit to PF05198, Initiation factor 3, score 1e-44 218494005239 PS00938 Initiation factor 3 signature. 218494005240 cytidylate kinase; Provisional; Region: cmk; PRK00023 218494005241 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 218494005242 CMP-binding site; other site 218494005243 The sites determining sugar specificity; other site 218494005244 HMMPfam hit to PF02224, Cytidylate kinase region, score 4.4e-61 218494005245 PS00017 ATP/GTP-binding site motif A (P-loop). 218494005246 1 probable transmembrane helix predicted for SSU1108 by TMHMM2.0 at aa 33-55 218494005247 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 218494005248 2 probable transmembrane helices predicted for SSU1110 by TMHMM2.0 at aa 16-38 and 43-62 218494005249 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 218494005250 active site 218494005251 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 3.2e-12 218494005252 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 218494005253 3 probable transmembrane helices predicted for SSU1112 by TMHMM2.0 at aa 5-20, 32-54 and 69-88 218494005254 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 218494005255 Ligand binding site; other site 218494005256 Putative Catalytic site; other site 218494005257 DXD motif; other site 218494005258 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 4.3e-23 218494005259 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 218494005260 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 218494005261 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 5.8e-25 218494005262 Rhamnan synthesis protein F; Region: RgpF; cl01529 218494005263 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 218494005264 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 218494005265 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 1.2e-12 218494005266 HMMPfam hit to PF05045, Rhamnan synthesis F, score 3.9e-35 218494005267 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 218494005268 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 218494005269 active site 218494005270 2 probable transmembrane helices predicted for SSU1116 by TMHMM2.0 at aa 251-273 and 294-316 218494005271 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 2.5e-42 218494005272 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 218494005273 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 218494005274 Ligand binding site; other site 218494005275 metal-binding site 218494005276 HMMPfam hit to PF01501, Glycosyl transferase, family 8, score 3.9e-43 218494005277 Predicted membrane protein (DUF2142); Region: DUF2142; cl01937 218494005278 9 probable transmembrane helices predicted for SSU1118 by TMHMM2.0 at aa 7-24, 120-142, 172-189, 204-226, 249-268, 307-329, 341-363, 378-397 and 410-432 218494005279 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 218494005280 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 218494005281 11 probable transmembrane helices predicted for SSU1119 by TMHMM2.0 at aa 10-32, 45-64, 79-101, 145-162, 166-184, 204-226, 254-276, 296-318, 328-347, 360-379 and 384-406 218494005282 HMMPfam hit to PF01943, Polysaccharide biosynthesis protein, score 0.0021 218494005283 Rhamnan synthesis protein F; Region: RgpF; cl01529 218494005284 HMMPfam hit to PF05045, Rhamnan synthesis F, score 3.2e-38 218494005285 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 218494005286 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 218494005287 Walker A/P-loop; other site 218494005288 ATP binding site [chemical binding]; other site 218494005289 Q-loop/lid; other site 218494005290 ABC transporter signature motif; other site 218494005291 Walker B; other site 218494005292 D-loop; other site 218494005293 H-loop/switch region; other site 218494005294 HMMPfam hit to PF00005, ABC transporter related, score 2.6e-37 218494005295 PS00211 ABC transporters family signature. 218494005296 PS00017 ATP/GTP-binding site motif A (P-loop). 218494005297 ABC-2 type transporter; Region: ABC2_membrane; cl11417 218494005298 6 probable transmembrane helices predicted for SSU1122 by TMHMM2.0 at aa 28-50, 60-77, 105-127, 137-159, 172-194 and 232-254 218494005299 HMMPfam hit to PF01061, ABC-2 type transporter, score 5.6e-15 218494005300 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 218494005301 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 218494005302 Probable Catalytic site; other site 218494005303 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 2.3e-24 218494005304 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 218494005305 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 218494005306 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 0.0046 218494005307 HMMPfam hit to PF09314, Protein of unknown function DUF1972, score 2.1e-148 218494005308 Sulfatase; Region: Sulfatase; cl10460 218494005309 9 probable transmembrane helices predicted for SSU1125 by TMHMM2.0 at aa 12-31, 159-181, 188-210, 225-244, 257-279, 289-306, 313-332, 365-387 and 408-425 218494005310 HMMPfam hit to PF00884, Sulphatase, score 8.2e-38 218494005311 Probable gene remnant. CDS lacks appropriate translational start site. Similar to an internal region of Listeria monocytogenes serotype 4b (strain F2365) N-acetylmuramoyl-l-alanine amidase UniProt:Q720Z4 (EMBL:AE017325) (774 aa) fasta scores: E()=4.8e-19, 44.231% id in 156 aa 218494005312 HMMPfam hit to PF01832, Mannosyl-glycoprotein endo-beta-N-acetylglucosamidase, score 8.8e-27 218494005313 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 218494005314 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 218494005315 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 218494005316 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 218494005317 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 218494005318 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 218494005319 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 218494005320 active site 218494005321 metal binding site [ion binding]; metal-binding site 218494005322 HMMPfam hit to PF01520, Cell wall hydrolase/autolysin, catalytic, score 6.2e-62 218494005323 HMMPfam hit to PF08481, GBS Bsp-like, score 7.4e-36 218494005324 HMMPfam hit to PF08481, GBS Bsp-like, score 7.4e-36 218494005325 HMMPfam hit to PF08481, GBS Bsp-like, score 7.4e-36 218494005326 HMMPfam hit to PF08481, GBS Bsp-like, score 7.4e-36 218494005327 HMMPfam hit to PF08481, GBS Bsp-like, score 1.4e-35 218494005328 HMMPfam hit to PF08481, GBS Bsp-like, score 1.4e-35 218494005329 PS00012 Phosphopantetheine attachment site. 218494005330 1 probable transmembrane helix predicted for SSU1128 by TMHMM2.0 at aa 13-35 218494005331 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 218494005332 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 218494005333 NADP binding site [chemical binding]; other site 218494005334 active site 218494005335 putative substrate binding site [chemical binding]; other site 218494005336 HMMPfam hit to PF04321, dTDP-4-dehydrorhamnose reductase, score 7.4e-142 218494005337 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 218494005338 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 218494005339 NAD binding site [chemical binding]; other site 218494005340 substrate binding site [chemical binding]; other site 218494005341 homodimer interface [polypeptide binding]; other site 218494005342 active site 218494005343 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 9e-79 218494005344 Cupin domain; Region: Cupin_2; cl09118 218494005345 HMMPfam hit to PF00908, dTDP-4-dehydrorhamnose 3,5-epimerase related, score 3.5e-15 218494005346 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 218494005347 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 218494005348 substrate binding site; other site 218494005349 tetramer interface; other site 218494005350 HMMPfam hit to PF00483, Nucleotidyl transferase, score 2.7e-118 218494005351 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 218494005352 8 probable transmembrane helices predicted for SSU1134 by TMHMM2.0 at aa 10-32, 44-66, 76-95, 127-149, 159-181, 194-216, 220-242 and 254-273 218494005353 HMMPfam hit to PF02535, Zinc/iron permease, score 3.4e-24 218494005354 Uncharacterized conserved protein [Function unknown]; Region: COG0327 218494005355 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 218494005356 HMMPfam hit to PF01784, NGG1p interacting factor 3, NIF3, score 2.1e-95 218494005357 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 218494005358 HMMPfam hit to PF04816, Protein of unknown function DUF633, score 2.3e-105 218494005359 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 218494005360 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 218494005361 HMMPfam hit to PF04271, DnaD and phage-associated region, score 2.2e-40 218494005362 Predicted helix-turn-helix motif with score 1068.000, SD 2.82 at aa 49-70, sequence LAPSEIAQATGKTVAQVNQAIE 218494005363 Homoserine O-succinyltransferase; Region: HTS; pfam04204 218494005364 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 218494005365 proposed active site lysine [active] 218494005366 conserved cys residue [active] 218494005367 HMMPfam hit to PF04204, Homoserine O-succinyltransferase, score 2.6e-204 218494005368 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 218494005369 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 8.6e-46 218494005370 PS00103 Purine/pyrimidine phosphoribosyl transferases signature. 218494005371 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 218494005372 1 probable transmembrane helix predicted for SSU1140 by TMHMM2.0 at aa 5-22 218494005373 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 218494005374 DHH family; Region: DHH; pfam01368 218494005375 DHHA1 domain; Region: DHHA1; pfam02272 218494005376 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 218494005377 Predicted helix-turn-helix motif with score 1035.000, SD 2.71 at aa 691-712, sequence MRVNKEAQKREISESQIYQELK 218494005378 HMMPfam hit to PF02272, Phosphoesterase, DHHA1, score 3.4e-13 218494005379 HMMPfam hit to PF01368, Phosphoesterase, RecJ-like, score 9.3e-56 218494005380 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 218494005381 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 218494005382 putative active site [active] 218494005383 catalytic site [active] 218494005384 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 218494005385 putative active site [active] 218494005386 catalytic site [active] 218494005387 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 9.6e-06 218494005388 HMMPfam hit to PF00614, Phospholipase D/Transphosphatidylase, score 9e-08 218494005389 3 probable transmembrane helices predicted for SSU1142 by TMHMM2.0 at aa 7-29, 34-56 and 68-90 218494005390 Equine herpesvirus glycoprotein gp2; Region: Herpes_gp2; pfam05955 218494005391 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_7; cd06244 218494005392 putative active site [active] 218494005393 Zn binding site [ion binding]; other site 218494005394 HMMPfam hit to PF00246, Peptidase M14, carboxypeptidase A, score 3e-06 218494005395 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 1.1e-05 218494005396 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494005397 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 218494005398 classical (c) SDRs; Region: SDR_c; cd05233 218494005399 NAD(P) binding site [chemical binding]; other site 218494005400 active site 218494005401 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 2.8e-19 218494005402 PS00061 Short-chain dehydrogenases/reductases family signature. 218494005403 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 218494005404 HMMPfam hit to PF00753, Beta-lactamase-like, score 4.5e-11 218494005405 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 218494005406 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 218494005407 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 218494005408 G1 box; other site 218494005409 GTP/Mg2+ binding site [chemical binding]; other site 218494005410 Switch I region; other site 218494005411 G2 box; other site 218494005412 G3 box; other site 218494005413 Switch II region; other site 218494005414 G4 box; other site 218494005415 G5 box; other site 218494005416 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 2.4e-37 218494005417 PS00017 ATP/GTP-binding site motif A (P-loop). 218494005418 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 218494005419 IPP transferase; Region: IPPT; cl00403 218494005420 HMMPfam hit to PF01715, tRNA isopentenyltransferase, score 3.2e-65 218494005421 PS00017 ATP/GTP-binding site motif A (P-loop). 218494005422 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 218494005423 1 probable transmembrane helix predicted for SSU1149 by TMHMM2.0 at aa 10-32 218494005424 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 218494005425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218494005426 putative substrate translocation pore; other site 218494005427 12 probable transmembrane helices predicted for SSU1150 by TMHMM2.0 at aa 7-29, 39-61, 74-93, 98-120, 127-149, 159-176, 202-224, 239-261, 274-296, 301-320, 332-354 and 359-381 218494005428 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 4e-23 218494005429 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 218494005430 substrate binding site [chemical binding]; other site 218494005431 THF binding site; other site 218494005432 zinc-binding site [ion binding]; other site 218494005433 Probable gene remnant. Similar to an internal region of Lactococcus lactis transposase (fragment) UniProt:Q9L979 (EMBL:AF179847) (397 aa) fasta scores: E()=4.7, 40.000% id in 40 aa 218494005434 Probable gene remnant. Similar to an internal region of Streptococcus criceti transposase UniProt:Q93RH3 (EMBL:AB042239) (287 aa) fasta scores: E()=2.7e-09, 54.000% id in 50 aa 218494005435 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 218494005436 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494005437 HMMPfam hit to PF02562, PhoH-like protein, score 4.3e-139 218494005438 PS00017 ATP/GTP-binding site motif A (P-loop). 218494005439 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 218494005440 HMMPfam hit to PF06855, Protein of unknown function DUF1250, score 3.6e-32 218494005441 Protein of unknown function (DUF419); Region: DUF419; cl15265 218494005442 HMMPfam hit to PF08818, Protein of unknown function DUF1801, score 2e-28 218494005443 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 218494005444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494005445 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 218494005446 HMMPfam hit to PF08546, Ketopantoate reductase ApbA/PanE, C-terminal, score 3e-47 218494005447 HMMPfam hit to PF02558, Ketopantoate reductase ApbA/PanE, N-terminal, score 2.3e-50 218494005448 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 218494005449 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 218494005450 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 218494005451 hinge region; other site 218494005452 HMMPfam hit to PF01765, Ribosome recycling factor, score 6.1e-92 218494005453 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 218494005454 putative nucleotide binding site [chemical binding]; other site 218494005455 uridine monophosphate binding site [chemical binding]; other site 218494005456 homohexameric interface [polypeptide binding]; other site 218494005457 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 2e-57 218494005458 MatE; Region: MatE; cl10513 218494005459 stage V sporulation protein B; Region: spore_V_B; TIGR02900 218494005460 14 probable transmembrane helices predicted for SSU1161 by TMHMM2.0 at aa 21-43, 58-80, 101-123, 133-155, 175-197, 201-223, 254-276, 304-323, 343-365, 375-397, 409-428, 433-452, 473-495 and 499-521 218494005461 HMMPfam hit to PF01943, Polysaccharide biosynthesis protein, score 1e-14 218494005462 putative S-transferase; Provisional; Region: PRK11752 218494005463 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 218494005464 C-terminal domain interface [polypeptide binding]; other site 218494005465 GSH binding site (G-site) [chemical binding]; other site 218494005466 dimer interface [polypeptide binding]; other site 218494005467 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 218494005468 N-terminal domain interface [polypeptide binding]; other site 218494005469 dimer interface [polypeptide binding]; other site 218494005470 substrate binding pocket (H-site) [chemical binding]; other site 218494005471 HMMPfam hit to PF00043, Glutathione S-transferase, C-terminal, score 6.7e-08 218494005472 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 218494005473 mRNA/rRNA interface [nucleotide binding]; other site 218494005474 HMMPfam hit to PF00687, Ribosomal protein L1, score 2.4e-117 218494005475 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 218494005476 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 218494005477 23S rRNA interface [nucleotide binding]; other site 218494005478 L7/L12 interface [polypeptide binding]; other site 218494005479 putative thiostrepton binding site; other site 218494005480 L25 interface [polypeptide binding]; other site 218494005481 PS00359 Ribosomal protein L11 signature. 218494005482 HMMPfam hit to PF00298, Ribosomal protein L11, score 1.8e-41 218494005483 HMMPfam hit to PF03946, Ribosomal protein L11, score 5.2e-35 218494005484 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 218494005485 3 probable transmembrane helices predicted for SSU1166 by TMHMM2.0 at aa 5-27, 62-84 and 97-119 218494005486 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 218494005487 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 218494005488 putative metal binding site [ion binding]; other site 218494005489 HMMPfam hit to PF00903, Glyoxalase/bleomycin resistance protein/dioxygenase, score 2.9e-15 218494005490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218494005491 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 218494005492 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494005493 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 218494005494 HMMPfam hit to PF01580, Cell divisionFtsK/SpoIIIE, score 2.1e-77 218494005495 PS00017 ATP/GTP-binding site motif A (P-loop). 218494005496 5 probable transmembrane helices predicted for SSU1168 by TMHMM2.0 at aa 28-50, 55-77, 90-112, 132-154 and 156-178 218494005497 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 218494005498 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 218494005499 substrate binding [chemical binding]; other site 218494005500 active site 218494005501 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 218494005502 HMMPfam hit to PF08244, Glycosyl hydrolase family 32, C-terminal, score 2.3e-05 218494005503 HMMPfam hit to PF00251, Glycosyl hydrolases family 32, N-terminal, score 3e-130 218494005504 PS00609 Glycosyl hydrolases family 32 active site. 218494005505 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 218494005506 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 5.7e-12 218494005507 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494005508 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 218494005509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494005510 dimer interface [polypeptide binding]; other site 218494005511 ABC-ATPase subunit interface; other site 218494005512 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.6e-16 218494005513 5 probable transmembrane helices predicted for SSU1171 by TMHMM2.0 at aa 19-41, 80-102, 111-133, 184-206 and 261-280 218494005514 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218494005515 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 218494005516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494005517 ABC-ATPase subunit interface; other site 218494005518 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 9.9e-12 218494005519 6 probable transmembrane helices predicted for SSU1172 by TMHMM2.0 at aa 21-43, 87-109, 121-143, 169-191, 217-239 and 272-294 218494005520 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218494005521 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218494005522 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218494005523 DNA binding site [nucleotide binding] 218494005524 domain linker motif; other site 218494005525 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 218494005526 dimerization interface [polypeptide binding]; other site 218494005527 ligand binding site [chemical binding]; other site 218494005528 sodium binding site [ion binding]; other site 218494005529 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 3.9e-09 218494005530 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 7e-13 218494005531 Predicted helix-turn-helix motif with score 2143.000, SD 6.49 at aa 7-28, sequence ITMKDVARVAGVSVGTVSRVIN 218494005532 PS00356 Bacterial regulatory proteins, lacI family signature. 218494005533 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 218494005534 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 218494005535 HMMPfam hit to PF00903, Glyoxalase/bleomycin resistance protein/dioxygenase, score 3.2e-11 218494005536 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 218494005537 1 probable transmembrane helix predicted for SSU1176 by TMHMM2.0 at aa 15-37 218494005538 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 218494005539 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 218494005540 active site 218494005541 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494005542 HMMPfam hit to PF00160, Peptidyl-prolyl cis-trans isomerase, cyclophilin-type, score 6.5e-56 218494005543 PS00170 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. 218494005544 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 218494005545 Transposase; Region: DDE_Tnp_ISL3; pfam01610 218494005546 Predicted helix-turn-helix motif with score 1137.000, SD 3.06 at aa 118-139, sequence QAMTHIAHRLSISTSSVMRKLN 218494005547 HMMPfam hit to PF01610, Transposase, IS204/IS1001/IS1096/IS1165, score 8.2e-53 218494005548 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 218494005549 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 218494005550 G1 box; other site 218494005551 putative GEF interaction site [polypeptide binding]; other site 218494005552 GTP/Mg2+ binding site [chemical binding]; other site 218494005553 Switch I region; other site 218494005554 G2 box; other site 218494005555 G3 box; other site 218494005556 Switch II region; other site 218494005557 G4 box; other site 218494005558 G5 box; other site 218494005559 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 218494005560 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 1.2e-12 218494005561 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 1.8e-65 218494005562 PS00301 GTP-binding elongation factors signature. 218494005563 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 218494005564 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 218494005565 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218494005566 motif II; other site 218494005567 9 probable transmembrane helices predicted for SSU1180 by TMHMM2.0 at aa 10-32, 171-193, 208-230, 552-574, 584-606, 622-644, 654-676, 683-702 and 712-731 218494005568 HMMPfam hit to PF00122, E1-E2 ATPase-associated region, score 4.1e-24 218494005569 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 3.3e-25 218494005570 PS00154 E1-E2 ATPases phosphorylation site. 218494005571 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 218494005572 Predicted integral membrane protein [Function unknown]; Region: COG5522; cl02331 218494005573 7 probable transmembrane helices predicted for SSU1181 by TMHMM2.0 at aa 15-35, 42-64, 69-88, 95-114, 124-146, 159-181 and 196-218 218494005574 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 218494005575 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 218494005576 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218494005577 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218494005578 HMMPfam hit to PF02875, Mur ligase, C-terminal, score 1.4e-05 218494005579 HMMPfam hit to PF08245, Mur ligase, central, score 9.6e-56 218494005580 HMMPfam hit to PF01225, Mur ligase, N-terminal, score 1.6e-12 218494005581 OsmC-like protein; Region: OsmC; cl00767 218494005582 HMMPfam hit to PF02566, OsmC-like protein, score 0.00074 218494005583 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 218494005584 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 218494005585 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 218494005586 HMMPfam hit to PF07478, D-alanine--D-alanine ligase, C-terminal, score 1.1e-102 218494005587 PS00844 D-alanine--D-alanine ligase signature 2. 218494005588 HMMPfam hit to PF01820, D-alanine--D-alanine ligase, N-terminal, score 1.8e-44 218494005589 PS00843 D-alanine--D-alanine ligase signature 1. 218494005590 recombination protein RecR; Reviewed; Region: recR; PRK00076 218494005591 RecR protein; Region: RecR; pfam02132 218494005592 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 218494005593 putative active site [active] 218494005594 putative metal-binding site [ion binding]; other site 218494005595 tetramer interface [polypeptide binding]; other site 218494005596 HMMPfam hit to PF01751, TOPRIM, score 3.4e-16 218494005597 HMMPfam hit to PF02132, Zinc finger C4-type, RecR, score 2.7e-17 218494005598 PS01300 RecR protein signature. 218494005599 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 218494005600 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 218494005601 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 218494005602 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 218494005603 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 1.7e-91 218494005604 HMMPfam hit to PF03717, Penicillin-binding protein, dimerisation domain, score 7.2e-23 218494005605 1 probable transmembrane helix predicted for SSU1186 by TMHMM2.0 at aa 20-39 218494005606 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 218494005607 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 218494005608 HMMPfam hit to PF00005, ABC transporter related, score 9.9e-29 218494005609 PS00211 ABC transporters family signature. 218494005610 PS00017 ATP/GTP-binding site motif A (P-loop). 218494005611 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 218494005612 ABC transporter; Region: ABC_tran_2; pfam12848 218494005613 HMMPfam hit to PF00005, ABC transporter related, score 1.1e-18 218494005614 PS00017 ATP/GTP-binding site motif A (P-loop). 218494005615 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 218494005616 HMMPfam hit to PF00753, Beta-lactamase-like, score 2.9e-21 218494005617 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 218494005618 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 218494005619 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 218494005620 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218494005621 dimer interface [polypeptide binding]; other site 218494005622 phosphorylation site [posttranslational modification] 218494005623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218494005624 ATP binding site [chemical binding]; other site 218494005625 Mg2+ binding site [ion binding]; other site 218494005626 G-X-G motif; other site 218494005627 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 8.6e-45 218494005628 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 2.2e-21 218494005629 HMMPfam hit to PF00989, PAS fold, score 5.6e-07 218494005630 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 0.0093 218494005631 1 probable transmembrane helix predicted for SSU1190 by TMHMM2.0 at aa 13-32 218494005632 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 218494005633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218494005634 active site 218494005635 phosphorylation site [posttranslational modification] 218494005636 intermolecular recognition site; other site 218494005637 dimerization interface [polypeptide binding]; other site 218494005638 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218494005639 DNA binding site [nucleotide binding] 218494005640 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 2e-24 218494005641 HMMPfam hit to PF00072, Response regulator receiver, score 5.2e-43 218494005642 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 218494005643 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 218494005644 Walker A/P-loop; other site 218494005645 ATP binding site [chemical binding]; other site 218494005646 Q-loop/lid; other site 218494005647 ABC transporter signature motif; other site 218494005648 Walker B; other site 218494005649 D-loop; other site 218494005650 H-loop/switch region; other site 218494005651 HMMPfam hit to PF00005, ABC transporter related, score 1.3e-70 218494005652 PS00017 ATP/GTP-binding site motif A (P-loop). 218494005653 PS00211 ABC transporters family signature. 218494005654 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917 218494005655 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218494005656 substrate binding pocket [chemical binding]; other site 218494005657 membrane-bound complex binding site; other site 218494005658 hinge residues; other site 218494005659 1 probable transmembrane helix predicted for SSU1193 by TMHMM2.0 at aa 7-25 218494005660 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 1.2e-59 218494005661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494005662 dimer interface [polypeptide binding]; other site 218494005663 conserved gate region; other site 218494005664 putative PBP binding loops; other site 218494005665 ABC-ATPase subunit interface; other site 218494005666 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 4.2e-22 218494005667 5 probable transmembrane helices predicted for SSU1194 by TMHMM2.0 at aa 27-49, 70-89, 93-115, 165-187 and 197-219 218494005668 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218494005669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494005670 dimer interface [polypeptide binding]; other site 218494005671 conserved gate region; other site 218494005672 putative PBP binding loops; other site 218494005673 ABC-ATPase subunit interface; other site 218494005674 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2e-24 218494005675 3 probable transmembrane helices predicted for SSU1195 by TMHMM2.0 at aa 22-44, 57-79 and 185-207 218494005676 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218494005677 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 218494005678 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 218494005679 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 218494005680 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 218494005681 active site 218494005682 dimer interface [polypeptide binding]; other site 218494005683 motif 1; other site 218494005684 motif 2; other site 218494005685 motif 3; other site 218494005686 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 218494005687 anticodon binding site; other site 218494005688 HMMPfam hit to PF03129, Anticodon-binding, score 2.1e-29 218494005689 HMMPfam hit to PF00587, Aminoacyl-tRNA synthetase, class II (G, H, P and S), score 4.9e-57 218494005690 HMMPfam hit to PF07973, Threonyl/alanyl tRNA synthetase, SAD, score 6.8e-25 218494005691 PS00017 ATP/GTP-binding site motif A (P-loop). 218494005692 HMMPfam hit to PF02824, TGS, score 1.4e-14 218494005693 4 probable transmembrane helices predicted for SSU1198 by TMHMM2.0 at aa 12-34, 44-66, 71-88 and 92-114 218494005694 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 218494005695 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 218494005696 putative ADP-binding pocket [chemical binding]; other site 218494005697 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 2.6e-28 218494005698 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 218494005699 HMMPfam hit to PF00534, Glycosyl transferase, group 1, score 7.3e-09 218494005700 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 218494005701 T surface-antigen of pili; Region: FctA; pfam12892 218494005702 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 218494005703 Xanthomonas avirulence protein, Avr/PthA; Region: Avirulence; pfam03377 218494005704 Gram positive anchor; Region: Gram_pos_anchor; cl15427 218494005705 2 probable transmembrane helices predicted for SSU1201 by TMHMM2.0 at aa 29-51 and 578-595 218494005706 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 0.00079 218494005707 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494005708 catabolite control protein A; Region: ccpA; TIGR01481 218494005709 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218494005710 DNA binding site [nucleotide binding] 218494005711 domain linker motif; other site 218494005712 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 218494005713 dimerization interface [polypeptide binding]; other site 218494005714 effector binding site; other site 218494005715 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 9.6e-08 218494005716 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 6.9e-14 218494005717 Predicted helix-turn-helix motif with score 2109.000, SD 6.37 at aa 8-29, sequence VTIYDVAREAGVSMATVSRVVN 218494005718 PS00356 Bacterial regulatory proteins, lacI family signature. 218494005719 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 218494005720 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 218494005721 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 218494005722 active site 218494005723 HMMPfam hit to PF01321, Creatinase, score 1.1e-14 218494005724 HMMPfam hit to PF00557, Peptidase M24, catalytic core, score 1.8e-70 218494005725 PS00491 Aminopeptidase P and proline dipeptidase signature. 218494005726 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 218494005727 HMMPfam hit to PF01702, Queuine/other tRNA-ribosyltransferase, score 2.9e-145 218494005728 Protein of unknown function (DUF975); Region: DUF975; cl10504 218494005729 HMMPfam hit to PF06161, Protein of unknown function DUF975, score 5.8e-45 218494005730 5 probable transmembrane helices predicted for SSU1205 by TMHMM2.0 at aa 21-40, 66-88, 121-143, 163-185 and 235-257 218494005731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494005732 HMMPfam hit to PF02629, CoA-binding, score 2.8e-18 218494005733 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494005734 DNA polymerase I; Provisional; Region: PRK05755 218494005735 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 218494005736 active site 218494005737 metal binding site 1 [ion binding]; metal-binding site 218494005738 putative 5' ssDNA interaction site; other site 218494005739 metal binding site 3; metal-binding site 218494005740 metal binding site 2 [ion binding]; metal-binding site 218494005741 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 218494005742 putative DNA binding site [nucleotide binding]; other site 218494005743 putative metal binding site [ion binding]; other site 218494005744 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 218494005745 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 218494005746 active site 218494005747 DNA binding site [nucleotide binding] 218494005748 catalytic site [active] 218494005749 HMMPfam hit to PF00476, DNA-directed DNA polymerase, score 2e-213 218494005750 PS00447 DNA polymerase family A signature. 218494005751 HMMPfam hit to PF01367, 5'-3' exonuclease, score 8.5e-54 218494005752 HMMPfam hit to PF02739, 5'-3' exonuclease, score 1.1e-94 218494005753 PS00453 FKBP-type peptidyl-prolyl cis-trans isomerase signature 1. 218494005754 5 probable transmembrane helices predicted for SSU1209 by TMHMM2.0 at aa 20-39, 44-66, 73-95, 99-121 and 142-164 218494005755 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 218494005756 Streptococcal surface antigen repeat; Region: Strep_SA_rep; pfam06696 218494005757 FtsX-like permease family; Region: FtsX; pfam02687 218494005758 FtsX-like permease family; Region: FtsX; pfam02687 218494005759 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 2.1e-25 218494005760 8 probable transmembrane helices predicted for SSU1210 by TMHMM2.0 at aa 21-43, 586-608, 638-660, 684-706, 757-779, 991-1013, 1045-1067 and 1082-1104 218494005761 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 2.3e-30 218494005762 HMMPfam hit to PF06696, Streptococcal surface antigen, score 0.0034 218494005763 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 218494005764 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 218494005765 Walker A/P-loop; other site 218494005766 ATP binding site [chemical binding]; other site 218494005767 Q-loop/lid; other site 218494005768 ABC transporter signature motif; other site 218494005769 Walker B; other site 218494005770 D-loop; other site 218494005771 H-loop/switch region; other site 218494005772 HMMPfam hit to PF00005, ABC transporter related, score 1.2e-65 218494005773 PS00211 ABC transporters family signature. 218494005774 PS00017 ATP/GTP-binding site motif A (P-loop). 218494005775 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 218494005776 dimer interface [polypeptide binding]; other site 218494005777 catalytic triad [active] 218494005778 peroxidatic and resolving cysteines [active] 218494005779 HMMPfam hit to PF08534, Redoxin, score 3.6e-34 218494005780 PS01265 Tpx family signature. 218494005781 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 218494005782 metal-binding site [ion binding] 218494005783 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 218494005784 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 218494005785 metal-binding site [ion binding] 218494005786 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 218494005787 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 218494005788 8 probable transmembrane helices predicted for SSU1214 by TMHMM2.0 at aa 161-180, 190-212, 233-252, 267-285, 419-441, 446-468, 761-783 and 787-809 218494005789 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 6.4e-39 218494005790 PS00154 E1-E2 ATPases phosphorylation site. 218494005791 HMMPfam hit to PF00122, E1-E2 ATPase-associated region, score 4e-112 218494005792 HMMPfam hit to PF00403, Heavy metal transport/detoxification protein, score 5.8e-16 218494005793 PS01047 Heavy-metal-associated domain. 218494005794 HMMPfam hit to PF00403, Heavy metal transport/detoxification protein, score 1.3e-14 218494005795 PS01047 Heavy-metal-associated domain. 218494005796 Peptidase family C69; Region: Peptidase_C69; cl01920 218494005797 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 7.8e-06 218494005798 2 probable transmembrane helices predicted for SSU1215 by TMHMM2.0 at aa 9-31 and 581-600 218494005799 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494005800 HMMPfam hit to PF03577, Peptidase C69, dipeptidase A, score 2.5e-141 218494005801 tellurite resistance protein TehB; Provisional; Region: PRK12335 218494005802 Domain of unknown function (DUF1971); Region: DUF1971; cl01451 218494005803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218494005804 S-adenosylmethionine binding site [chemical binding]; other site 218494005805 HMMPfam hit to PF03848, Tellurite resistance methyltransferase, TehB, core, score 1.9e-134 218494005806 HMMPfam hit to PF09313, Protein of unknown function DUF1971, score 5.6e-35 218494005807 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 218494005808 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 218494005809 catalytic Zn binding site [ion binding]; other site 218494005810 NAD(P) binding site [chemical binding]; other site 218494005811 structural Zn binding site [ion binding]; other site 218494005812 HMMPfam hit to PF08240, Alcohol dehydrogenase GroES-like, score 1.6e-29 218494005813 PS00059 Zinc-containing alcohol dehydrogenases signature. 218494005814 HMMPfam hit to PF00107, Alcohol dehydrogenase, zinc-binding, score 7.8e-31 218494005815 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 218494005816 SmpB-tmRNA interface; other site 218494005817 HMMPfam hit to PF01668, SmpB protein, score 2.8e-41 218494005818 PS01317 Protein smpB signature. 218494005819 ribonuclease R; Region: RNase_R; TIGR02063 218494005820 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 218494005821 RNB domain; Region: RNB; pfam00773 218494005822 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 218494005823 RNA binding site [nucleotide binding]; other site 218494005824 HMMPfam hit to PF00575, S1, RNA binding, score 1.7e-14 218494005825 HMMPfam hit to PF00773, Ribonuclease II and R, score 1.8e-152 218494005826 PS01175 Ribonuclease II family signature. 218494005827 HMMPfam hit to PF08206, Ribonuclease B, OB region N-terminal, score 8e-21 218494005828 Preprotein translocase SecG subunit; Region: SecG; cl09123 218494005829 HMMPfam hit to PF03840, Preprotein translocase SecG subunit, score 5.8e-26 218494005830 2 probable transmembrane helices predicted for SSU1220 by TMHMM2.0 at aa 5-24 and 51-73 218494005831 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 218494005832 HMMPfam hit to PF00471, Ribosomal protein L33, score 3.4e-19 218494005833 PS00582 Ribosomal protein L33 signature. 218494005834 drug efflux system protein MdtG; Provisional; Region: PRK09874 218494005835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218494005836 putative substrate translocation pore; other site 218494005837 9 probable transmembrane helices predicted for SSU1222 by TMHMM2.0 at aa 15-37, 49-71, 86-108, 139-161, 166-188, 218-240, 250-272, 284-306 and 368-390 218494005838 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 6.3e-56 218494005839 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 218494005840 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 218494005841 CoA-binding site [chemical binding]; other site 218494005842 ATP-binding [chemical binding]; other site 218494005843 HMMPfam hit to PF01121, Dephospho-CoA kinase, score 3.5e-56 218494005844 PS00017 ATP/GTP-binding site motif A (P-loop). 218494005845 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 218494005846 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 218494005847 DNA binding site [nucleotide binding] 218494005848 catalytic residue [active] 218494005849 H2TH interface [polypeptide binding]; other site 218494005850 putative catalytic residues [active] 218494005851 turnover-facilitating residue; other site 218494005852 intercalation triad [nucleotide binding]; other site 218494005853 8OG recognition residue [nucleotide binding]; other site 218494005854 putative reading head residues; other site 218494005855 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 218494005856 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 218494005857 HMMPfam hit to PF06827, Formamidopyrimidine-DNA glycolase, C-terminal, score 8.3e-06 218494005858 PS01242 Formamidopyrimidine-DNA glycosylase signature. 218494005859 HMMPfam hit to PF06831, Formamidopyrimidine-DNA glycolase, H2TH DNA binding, score 1.7e-44 218494005860 HMMPfam hit to PF01149, Formamidopyrimidine-DNA glycosylase, catalytic, score 3.1e-53 218494005861 GTPase Era; Reviewed; Region: era; PRK00089 218494005862 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly...; Region: Era; cd04163 218494005863 G1 box; other site 218494005864 GTP/Mg2+ binding site [chemical binding]; other site 218494005865 Switch I region; other site 218494005866 G2 box; other site 218494005867 Switch II region; other site 218494005868 G3 box; other site 218494005869 G4 box; other site 218494005870 G5 box; other site 218494005871 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 218494005872 HMMPfam hit to PF07650, K Homology, type 2, score 6.8e-30 218494005873 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 2.6e-42 218494005874 PS00017 ATP/GTP-binding site motif A (P-loop). 218494005875 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 218494005876 2 probable transmembrane helices predicted for SSU1226 by TMHMM2.0 at aa 42-64 and 104-126 218494005877 HMMPfam hit to PF01219, Prokaryotic diacylglycerol kinase, score 7.6e-51 218494005878 PS01069 Prokaryotic diacylglycerol kinase signature. 218494005879 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 218494005880 HMMPfam hit to PF02130, Protein of unknown function UPF0054, score 5.7e-25 218494005881 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 218494005882 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 218494005883 putative active site [active] 218494005884 HMMPfam hit to PF01418, Helix-turn-helix protein RpiR, score 5.6e-06 218494005885 Predicted helix-turn-helix motif with score 1154.000, SD 3.12 at aa 40-61, sequence LSQENTIQQLHISPSALTRFAK 218494005886 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 8.4e-09 218494005887 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 218494005888 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 218494005889 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 218494005890 active site turn [active] 218494005891 phosphorylation site [posttranslational modification] 218494005892 HMMPfam hit to PF00367, Phosphotransferase system, EIIB, score 1.2e-12 218494005893 9 probable transmembrane helices predicted for SSU1229 by TMHMM2.0 at aa 12-34, 54-76, 89-111, 153-175, 195-217, 262-284, 304-326, 341-363 and 370-389 218494005894 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1.4e-89 218494005895 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 218494005896 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 218494005897 putative active site cavity [active] 218494005898 HMMPfam hit to PF04131, N-acetylmannosamine-6-phosphate epimerase, score 6.8e-122 218494005899 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 218494005900 HMMPfam hit to PF01289, Thiol-activated cytolysin, score 2.6e-231 218494005901 1 probable transmembrane helix predicted for SSU1231 by TMHMM2.0 at aa 7-26 218494005902 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 218494005903 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218494005904 motif II; other site 218494005905 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 5.2e-23 218494005906 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 218494005907 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 218494005908 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 218494005909 Walker A/P-loop; other site 218494005910 ATP binding site [chemical binding]; other site 218494005911 Q-loop/lid; other site 218494005912 ABC transporter signature motif; other site 218494005913 Walker B; other site 218494005914 D-loop; other site 218494005915 H-loop/switch region; other site 218494005916 HMMPfam hit to PF00005, ABC transporter related, score 1.2e-56 218494005917 PS00211 ABC transporters family signature. 218494005918 PS00017 ATP/GTP-binding site motif A (P-loop). 218494005919 6 probable transmembrane helices predicted for SSU1233 by TMHMM2.0 at aa 17-39, 59-81, 136-158, 163-182, 252-274 and 284-302 218494005920 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 7.6e-22 218494005921 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 218494005922 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 218494005923 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494005924 Walker A/P-loop; other site 218494005925 ATP binding site [chemical binding]; other site 218494005926 Q-loop/lid; other site 218494005927 ABC transporter signature motif; other site 218494005928 Walker B; other site 218494005929 D-loop; other site 218494005930 H-loop/switch region; other site 218494005931 HMMPfam hit to PF00005, ABC transporter related, score 7.5e-51 218494005932 PS00211 ABC transporters family signature. 218494005933 PS00017 ATP/GTP-binding site motif A (P-loop). 218494005934 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 2.5e-20 218494005935 5 probable transmembrane helices predicted for SSU1234 by TMHMM2.0 at aa 16-38, 58-80, 125-147, 157-176 and 239-261 218494005936 PS00036 bZIP transcription factors basic domain signature. 218494005937 FeoA domain; Region: FeoA; cl00838 218494005938 FeoA domain; Region: FeoA; cl00838 218494005939 HMMPfam hit to PF04023, Ferrous iron transporter, FeoA subunit, score 3.9e-11 218494005940 HMMPfam hit to PF04023, Ferrous iron transporter, FeoA subunit, score 7.9e-19 218494005941 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 218494005942 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 218494005943 G1 box; other site 218494005944 GTP/Mg2+ binding site [chemical binding]; other site 218494005945 Switch I region; other site 218494005946 G2 box; other site 218494005947 G3 box; other site 218494005948 Switch II region; other site 218494005949 G4 box; other site 218494005950 G5 box; other site 218494005951 Nucleoside recognition; Region: Gate; cl00486 218494005952 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 218494005953 Nucleoside recognition; Region: Gate; cl00486 218494005954 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 2.9e-35 218494005955 PS00017 ATP/GTP-binding site motif A (P-loop). 218494005956 HMMPfam hit to PF02421, Ferrous iron transport protein B, N-terminal, score 1e-42 218494005957 10 probable transmembrane helices predicted for SSU1237 by TMHMM2.0 at aa 280-302, 344-366, 387-409, 450-472, 511-530, 545-562, 567-589, 609-631, 643-665 and 675-694 218494005958 HMMPfam hit to PF07670, Nucleoside recognition, score 1.9e-17 218494005959 HMMPfam hit to PF07664, Ferrous iron transport B, C-terminal, score 1e-17 218494005960 HMMPfam hit to PF07670, Nucleoside recognition, score 3.8e-16 218494005961 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 218494005962 FtsX-like permease family; Region: FtsX; pfam02687 218494005963 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 1.3e-29 218494005964 4 probable transmembrane helices predicted for SSU1238 by TMHMM2.0 at aa 26-48, 190-212, 233-255 and 282-304 218494005965 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 218494005966 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494005967 Walker A/P-loop; other site 218494005968 ATP binding site [chemical binding]; other site 218494005969 Q-loop/lid; other site 218494005970 ABC transporter signature motif; other site 218494005971 Walker B; other site 218494005972 D-loop; other site 218494005973 H-loop/switch region; other site 218494005974 HMMPfam hit to PF00005, ABC transporter related, score 4.3e-61 218494005975 PS00211 ABC transporters family signature. 218494005976 PS00017 ATP/GTP-binding site motif A (P-loop). 218494005977 peptide chain release factor 2; Validated; Region: prfB; PRK00578 218494005978 RF-1 domain; Region: RF-1; cl02875 218494005979 RF-1 domain; Region: RF-1; cl02875 218494005980 HMMPfam hit to PF00472, Class I peptide chain release factor, score 1.8e-63 218494005981 HMMPfam hit to PF03462, PCRF, score 6.7e-52 218494005982 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 218494005983 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 218494005984 HMMPfam hit to PF00037, 4Fe-4S ferredoxin, iron-sulphur binding, score 0.0044 218494005985 PS00198 4Fe-4S ferredoxins, iron-sulfur binding region signature. 218494005986 HMMPfam hit to PF08331, Region of unknown function DUF1730, score 3.2e-27 218494005987 VanZ like family; Region: VanZ; cl01971 218494005988 5 probable transmembrane helices predicted for SSU1242 by TMHMM2.0 at aa 7-24, 60-78, 83-105, 115-132 and 139-161 218494005989 HMMPfam hit to PF04892, VanZ like protein, score 2.3e-23 218494005990 TM2 domain; Region: TM2; cl00984 218494005991 2 probable transmembrane helices predicted for SSU1243 by TMHMM2.0 at aa 47-66 and 76-98 218494005992 HMMPfam hit to PF05154, TM2, score 4.8e-11 218494005993 2 probable transmembrane helices predicted for SSU1245 by TMHMM2.0 at aa 10-27 and 34-56 218494005994 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 218494005995 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 218494005996 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 218494005997 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 218494005998 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 218494005999 HMMPfam hit to PF00689, ATPase, P-type cation-transporter, C-terminal, score 1.2e-21 218494006000 10 probable transmembrane helices predicted for SSU1246 by TMHMM2.0 at aa 65-82, 86-105, 253-275, 285-307, 683-705, 711-730, 751-773, 788-810, 830-852 and 862-884 218494006001 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 4.1e-21 218494006002 PS00154 E1-E2 ATPases phosphorylation site. 218494006003 HMMPfam hit to PF00122, E1-E2 ATPase-associated region, score 3.3e-100 218494006004 HMMPfam hit to PF00690, ATPase, P-type cation-transporter, N-terminal, score 7.1e-23 218494006005 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 218494006006 Integrase core domain; Region: rve; cl01316 218494006007 Predicted helix-turn-helix motif with score 1377.000, SD 3.88 at aa 22-43, sequence KPFSAIAAKLGKDPSTISKEVR 218494006008 HMMPfam hit to PF00665, Integrase, catalytic core, score 9.1e-14 218494006009 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 218494006010 5 probable transmembrane helices predicted for SSU1248 by TMHMM2.0 at aa 10-32, 45-67, 82-104, 134-156 and 166-188 218494006011 HMMPfam hit to PF09335, SNARE associated Golgi protein, score 2e-17 218494006012 CDS contains a frameshift after codon 16, and is disrupted by the insertion of an IS element after codon 50. Similar to Photorhabdus luminescens subsp. laumondii IS200 family ISPlu5A transposase UniProt:Q7MYQ8 (EMBL:BX571874) (151 aa) fasta scores: E()=3.1e-40, 69.799% id in 149 aa 218494006013 HMMPfam hit to PF01797, Transposase IS200-like, score 6.9e-15 218494006014 CDS lacks appropriate translational start site. CDS contains nonsense mutations after codons 175 (amber) and 306 (opal). Similar to Streptococcus agalactiae serotype V IS1548 transposase UniProt:Q8CM96 (EMBL:AE014200) (377 aa) fasta scores: E()=2.3e-103, 70.822% id in 377 aa 218494006015 HMMPfam hit to PF01609, Transposase, IS4-like, score 3.7e-08 218494006016 Domain of unknown function DUF59; Region: DUF59; cl00941 218494006017 HMMPfam hit to PF01883, Protein of unknown function DUF59, score 1.4e-31 218494006018 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 218494006019 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 218494006020 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 218494006021 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 218494006022 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 218494006023 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 218494006024 DNA binding residues [nucleotide binding] 218494006025 HMMPfam hit to PF04545, RNA polymerase sigma-70 region 4, score 1e-26 218494006026 PS00716 Sigma-70 factors family signature 2. 218494006027 Predicted helix-turn-helix motif with score 1807.000, SD 5.34 at aa 330-351, sequence RTLEDVGKVFNVTRERIRQIEA 218494006028 HMMPfam hit to PF04539, RNA polymerase sigma-70 region 3, score 1.4e-41 218494006029 Predicted helix-turn-helix motif with score 1292.000, SD 3.59 at aa 237-258, sequence PTPEQIAERMDMTPEKVREILK 218494006030 HMMPfam hit to PF04542, RNA polymerase sigma-70 region 2, score 1.3e-29 218494006031 PS00715 Sigma-70 factors family signature 1. 218494006032 HMMPfam hit to PF00140, RNA polymerase sigma-70 region 1.2, score 5.4e-17 218494006033 HMMPfam hit to PF03979, RNA polymerase sigma factor 70, region 1.1, score 2.5e-05 218494006034 DNA primase; Validated; Region: dnaG; PRK05667 218494006035 CHC2 zinc finger; Region: zf-CHC2; cl15369 218494006036 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 218494006037 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 218494006038 active site 218494006039 metal binding site [ion binding]; metal-binding site 218494006040 interdomain interaction site; other site 218494006041 HMMPfam hit to PF01751, TOPRIM, score 7e-17 218494006042 HMMPfam hit to PF08275, DNA primase catalytic core, N-terminal, score 3.5e-50 218494006043 HMMPfam hit to PF01807, Zinc finger, CHC2-type, score 2.4e-49 218494006044 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 218494006045 HMMPfam hit to PF01741, Large-conductance mechanosensitive channel, score 1.7e-41 218494006046 2 probable transmembrane helices predicted for SSU1257 by TMHMM2.0 at aa 9-31 and 68-87 218494006047 PS01327 Large-conductance mechanosensitive channels mscL family signature. 218494006048 UDP-glucose 4-epimerase; Region: PLN02240 218494006049 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 218494006050 NAD binding site [chemical binding]; other site 218494006051 homodimer interface [polypeptide binding]; other site 218494006052 active site 218494006053 substrate binding site [chemical binding]; other site 218494006054 HMMPfam hit to PF01370, NAD-dependent epimerase/dehydratase, score 9.1e-71 218494006055 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 218494006056 HMMPfam hit to PF01165, Ribosomal protein S21, score 6.3e-31 218494006057 PS01181 Ribosomal protein S21 signature. 218494006058 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 218494006059 4 probable transmembrane helices predicted for SSU1260 by TMHMM2.0 at aa 7-29, 91-113, 134-156 and 179-201 218494006060 HMMPfam hit to PF07314, Integral membrane protein 1906, score 6.8e-81 218494006061 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 218494006062 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218494006063 active site 218494006064 motif I; other site 218494006065 motif II; other site 218494006066 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218494006067 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 4.4e-18 218494006068 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 218494006069 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 218494006070 nudix motif; other site 218494006071 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 2e-21 218494006072 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 218494006073 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 218494006074 active site 218494006075 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 218494006076 HMMPfam hit to PF01643, Acyl-ACP thioesterase, score 4e-96 218494006077 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 218494006078 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218494006079 FeS/SAM binding site; other site 218494006080 HemN C-terminal region; Region: HemN_C; pfam06969 218494006081 HMMPfam hit to PF06969, HemN, C-terminal, score 9.3e-41 218494006082 HMMPfam hit to PF04055, Radical SAM, score 2.9e-33 218494006083 CDS contains a nonsense mutation (amber) after codon 97. Similar to Streptococcus mutans hypothetical protein hypothetical protein SMU.239c UniProt:Q8DW37 (EMBL:AE014873) (196 aa) fasta scores: E()=3.1e-15, 32.530% id in 166 aa 218494006084 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 218494006085 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 218494006086 HMMPfam hit to PF00343, Glycosyl transferase, family 35, score 6.2e-204 218494006087 PS00102 Phosphorylase pyridoxal-phosphate attachment site. 218494006088 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 218494006089 HMMPfam hit to PF01048, Nucleoside phosphorylase, score 1.5e-101 218494006090 PS01232 Purine and other phosphorylases family 1 signature. 218494006091 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 218494006092 HMMPfam hit to PF00896, Purine phosphorylase, family 2, score 5.4e-103 218494006093 PS01240 Purine and other phosphorylases family 2 signature. 218494006094 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 218494006095 ArsC family; Region: ArsC; pfam03960 218494006096 HMMPfam hit to PF03960, Arsenate reductase and related, score 5.4e-13 218494006097 Sulfatase; Region: Sulfatase; cl10460 218494006098 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 218494006099 HMMPfam hit to PF01676, Metalloenzyme, score 1.6e-38 218494006100 HMMPfam hit to PF08342, Phosphopentomutase N-terminal, score 6.8e-45 218494006101 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 218494006102 tetramer (dimer of dimers) interface [polypeptide binding]; other site 218494006103 active site 218494006104 dimer interface [polypeptide binding]; other site 218494006105 HMMPfam hit to PF06026, Ribose 5-phosphate isomerase, score 7.3e-88 218494006106 Probable gene remnant. CDS is truncated at the N-terminus in comparison to to similar proteins, for example, similar to Streptococcus pneumoniae type I restriction-modification system S subunit UniProt:Q97S80 (EMBL:AE007362) (522 aa) fasta scores: E()=9e-39, 35.805% id in 472 aa, and to Escherichia coli hsds type I restriction enzyme EcoEI specificity protein UniProt:P19705 (EMBL:ECHSDS) (594 aa) fasta scores: E()=7e-09, 24.649% id in 499 aa 218494006107 HMMPfam hit to PF01420, Restriction endonuclease, type I, S subunit, EcoBI, score 6.9e-18 218494006108 HMMPfam hit to PF01420, Restriction endonuclease, type I, S subunit, EcoBI, score 0.00028 218494006109 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 218494006110 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 218494006111 HMMPfam hit to PF01420, Restriction endonuclease, type I, S subunit, EcoBI, score 0.00012 218494006112 HMMPfam hit to PF01420, Restriction endonuclease, type I, S subunit, EcoBI, score 1.8e-32 218494006113 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 218494006114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 218494006115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 218494006116 HMMPfam hit to PF02384, N-6 DNA methylase, score 5.3e-72 218494006117 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 218494006118 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218494006119 ATP binding site [chemical binding]; other site 218494006120 putative Mg++ binding site [ion binding]; other site 218494006121 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 218494006122 HMMPfam hit to PF08463, Restriction endonuclease, type I, EcoEI, R subunit/Type III, Res subunit, C-terminal, score 6.2e-98 218494006123 HMMPfam hit to PF04851, Restriction endonuclease, type I, R subunit/Type III, Res subunit, score 1.5e-61 218494006124 PS00044 Bacterial regulatory proteins, lysR family signature. 218494006125 HMMPfam hit to PF04313, Restriction endonuclease, type I, EcoRI, R subunit/Type III, Res subunit, N terminus, score 1.8e-22 218494006126 PS00447 DNA polymerase family A signature. 218494006127 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 218494006128 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 218494006129 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 218494006130 G1 box; other site 218494006131 GTP/Mg2+ binding site [chemical binding]; other site 218494006132 Switch I region; other site 218494006133 G2 box; other site 218494006134 Switch II region; other site 218494006135 G3 box; other site 218494006136 G4 box; other site 218494006137 G5 box; other site 218494006138 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 218494006139 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 9.5e-46 218494006140 PS00017 ATP/GTP-binding site motif A (P-loop). 218494006141 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 218494006142 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 218494006143 HMMPfam hit to PF03149, Flotillin, score 1.1e-09 218494006144 HMMPfam hit to PF01145, Band 7 protein, score 3.6e-15 218494006145 1 probable transmembrane helix predicted for SSU1278 by TMHMM2.0 at aa 7-29 218494006146 LemA family; Region: LemA; cl00742 218494006147 HMMPfam hit to PF04011, LemA, score 2.1e-64 218494006148 1 probable transmembrane helix predicted for SSU1279 by TMHMM2.0 at aa 5-24 218494006149 Domain of unknown function (DUF477); Region: DUF477; cl01535 218494006150 2 probable transmembrane helices predicted for SSU1280 by TMHMM2.0 at aa 7-26 and 187-204 218494006151 HMMPfam hit to PF04536, Protein of unknown function DUF477, score 1e-17 218494006152 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 218494006153 putative uracil binding site [chemical binding]; other site 218494006154 putative active site [active] 218494006155 HMMPfam hit to PF03167, Uracil-DNA glycosylase superfamily, score 8.1e-08 218494006156 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 218494006157 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218494006158 Coenzyme A binding pocket [chemical binding]; other site 218494006159 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 4.8e-10 218494006160 dipeptidase PepV; Reviewed; Region: PRK07318 218494006161 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 218494006162 active site 218494006163 metal binding site [ion binding]; metal-binding site 218494006164 HMMPfam hit to PF01546, Peptidase M20, score 1.1e-29 218494006165 PS00759 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. 218494006166 PS00758 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. 218494006167 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 218494006168 HMMPfam hit to PF00375, Sodium:dicarboxylate symporter, score 1.1e-120 218494006169 8 probable transmembrane helices predicted for SSU1284 by TMHMM2.0 at aa 17-39, 43-65, 78-100, 136-158, 179-201, 211-233, 293-315 and 325-347 218494006170 1 probable transmembrane helix predicted for SSU1287 by TMHMM2.0 at aa 13-35 218494006171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218494006172 HMMPfam hit to PF08241, Methyltransferase type 11, score 4.6e-15 218494006173 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 218494006174 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 218494006175 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494006176 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 218494006177 ABC transporter; Region: ABC_tran_2; pfam12848 218494006178 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 218494006179 HMMPfam hit to PF00005, ABC transporter related, score 4.8e-38 218494006180 PS00211 ABC transporters family signature. 218494006181 PS00017 ATP/GTP-binding site motif A (P-loop). 218494006182 HMMPfam hit to PF00005, ABC transporter related, score 2.3e-41 218494006183 PS00211 ABC transporters family signature. 218494006184 PS00017 ATP/GTP-binding site motif A (P-loop). 218494006185 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 218494006186 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 218494006187 active site 218494006188 substrate binding site [chemical binding]; other site 218494006189 metal binding site [ion binding]; metal-binding site 218494006190 HMMPfam hit to PF00408, Phosphoglucomutase/phosphomannomutase C-terminal, score 8.6e-10 218494006191 HMMPfam hit to PF02880, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III, score 3e-27 218494006192 HMMPfam hit to PF02879, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II, score 4.1e-21 218494006193 HMMPfam hit to PF02878, Phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I, score 1.3e-58 218494006194 PS00710 Phosphoglucomutase and phosphomannomutase phosphoserine signature. 218494006195 YbbR-like protein; Region: YbbR; pfam07949 218494006196 YbbR-like protein; Region: YbbR; pfam07949 218494006197 HMMPfam hit to PF07949, YbbR-like, score 4.1e-11 218494006198 HMMPfam hit to PF07949, YbbR-like, score 3.2e-11 218494006199 1 probable transmembrane helix predicted for SSU1291 by TMHMM2.0 at aa 7-26 218494006200 Uncharacterized conserved protein [Function unknown]; Region: COG1624 218494006201 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 218494006202 HMMPfam hit to PF02457, Protein of unknown function DUF147, score 9e-56 218494006203 3 probable transmembrane helices predicted for SSU1292 by TMHMM2.0 at aa 15-37, 50-69 and 73-95 218494006204 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 218494006205 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218494006206 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 218494006207 HMMPfam hit to PF08245, Mur ligase, central, score 3.2e-07 218494006208 HMMPfam hit to PF08353, Region of unknown function DUF1727, score 7.1e-58 218494006209 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 218494006210 catalytic triad [active] 218494006211 HMMPfam hit to PF07685, CobB/CobQ-like glutamine amidotransferase, score 1.1e-49 218494006212 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 218494006213 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218494006214 S-adenosylmethionine binding site [chemical binding]; other site 218494006215 HMMPfam hit to PF08241, Methyltransferase type 11, score 4.8e-11 218494006216 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218494006217 Transcriptional regulator [DNA replication, recombination and repair]; Region: tfx; COG1356 218494006218 non-specific DNA binding site [nucleotide binding]; other site 218494006219 salt bridge; other site 218494006220 sequence-specific DNA binding site [nucleotide binding]; other site 218494006221 2 probable transmembrane helices predicted for SSU1296 by TMHMM2.0 at aa 89-111 and 126-148 218494006222 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 4.3e-18 218494006223 Predicted helix-turn-helix motif with score 2462.000, SD 7.57 at aa 16-37, sequence LTQEQFALKLNVTRQAVSNWEN 218494006224 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 218494006225 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 218494006226 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494006227 Walker A/P-loop; other site 218494006228 ATP binding site [chemical binding]; other site 218494006229 Q-loop/lid; other site 218494006230 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 218494006231 ABC transporter signature motif; other site 218494006232 Walker B; other site 218494006233 D-loop; other site 218494006234 ABC transporter; Region: ABC_tran_2; pfam12848 218494006235 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 218494006236 polar chromosome segregation protein; Reviewed; Region: racA; PRK13182 218494006237 HMMPfam hit to PF00005, ABC transporter related, score 2.2e-37 218494006238 PS00211 ABC transporters family signature. 218494006239 PS00017 ATP/GTP-binding site motif A (P-loop). 218494006240 HMMPfam hit to PF00005, ABC transporter related, score 3.6e-42 218494006241 PS00017 ATP/GTP-binding site motif A (P-loop). 218494006242 1 probable transmembrane helix predicted for SSU1299 by TMHMM2.0 at aa 89-111 218494006243 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5549 218494006244 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 218494006245 active site 218494006246 HMMPfam hit to PF00413, Peptidase M10A and M12B, matrixin and adamalysin, score 0.00047 218494006247 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218494006248 1 probable transmembrane helix predicted for SSU1300 by TMHMM2.0 at aa 13-35 218494006249 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494006250 Predicted esterase [General function prediction only]; Region: COG0627 218494006251 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 218494006252 HMMPfam hit to PF00756, esterase, score 6.9e-05 218494006253 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 218494006254 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 218494006255 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 218494006256 HMMPfam hit to PF07521, RNA-metabolising metallo-beta-lactamase, score 8.1e-12 218494006257 HMMPfam hit to PF00753, Beta-lactamase-like, score 9.8e-25 218494006258 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494006259 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 218494006260 putative deacylase active site [active] 218494006261 HMMPfam hit to PF04073, YbaK/prolyl-tRNA synthetase associated region, score 5.1e-05 218494006262 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 218494006263 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494006264 Walker A/P-loop; other site 218494006265 ATP binding site [chemical binding]; other site 218494006266 Q-loop/lid; other site 218494006267 ABC transporter signature motif; other site 218494006268 Walker B; other site 218494006269 D-loop; other site 218494006270 H-loop/switch region; other site 218494006271 HMMPfam hit to PF00005, ABC transporter related, score 7.3e-49 218494006272 PS00211 ABC transporters family signature. 218494006273 PS00017 ATP/GTP-binding site motif A (P-loop). 218494006274 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 218494006275 TM-ABC transporter signature motif; other site 218494006276 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 1.7e-16 218494006277 7 probable transmembrane helices predicted for SSU1306 by TMHMM2.0 at aa 9-28, 54-76, 83-105, 125-147, 176-195, 205-227 and 232-254 218494006278 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 218494006279 zinc binding site [ion binding]; other site 218494006280 putative ligand binding site [chemical binding]; other site 218494006281 HMMPfam hit to PF04392, ABC transporter substrate binding protein, score 2.8e-127 218494006282 1 probable transmembrane helix predicted for SSU1307 by TMHMM2.0 at aa 7-24 218494006283 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 218494006284 HMMPfam hit to PF00232, Glycoside hydrolase, family 1, score 2.6e-158 218494006285 PS00572 Glycosyl hydrolases family 1 active site. 218494006286 PS00653 Glycosyl hydrolases family 1 N-terminal signature. 218494006287 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 218494006288 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218494006289 active site turn [active] 218494006290 phosphorylation site [posttranslational modification] 218494006291 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 218494006292 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 218494006293 HPr interaction site; other site 218494006294 glycerol kinase (GK) interaction site [polypeptide binding]; other site 218494006295 active site 218494006296 phosphorylation site [posttranslational modification] 218494006297 HMMPfam hit to PF00358, Phosphotransferase system, sugar-specific permease EIIA 1 domain, score 6.3e-71 218494006298 PS00371 PTS EIIA domains phosphorylation site signature 1. 218494006299 10 probable transmembrane helices predicted for SSU1309 by TMHMM2.0 at aa 110-132, 142-161, 168-190, 205-224, 245-267, 282-304, 317-339, 349-371, 378-397 and 422-444 218494006300 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 7.6e-28 218494006301 HMMPfam hit to PF00367, Phosphotransferase system, EIIB, score 6.1e-10 218494006302 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 218494006303 transcriptional antiterminator BglG; Provisional; Region: PRK09772 218494006304 CAT RNA binding domain; Region: CAT_RBD; cl03904 218494006305 PRD domain; Region: PRD; cl15445 218494006306 PRD domain; Region: PRD; cl15445 218494006307 HMMPfam hit to PF00874, PRD, score 2.7e-11 218494006308 HMMPfam hit to PF00874, PRD, score 3.2e-15 218494006309 HMMPfam hit to PF03123, CAT RNA-binding region, score 2.7e-27 218494006310 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 218494006311 Domain of unknown function (DUF814); Region: DUF814; pfam05670 218494006312 HMMPfam hit to PF05833, Fibronectin-binding A, N-terminal, score 1.5e-253 218494006313 HMMPfam hit to PF05670, Protein of unknown function DUF814, score 1.3e-38 218494006314 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 218494006315 HMMPfam hit to PF03306, Alpha-acetolactate decarboxylase, score 1.4e-107 218494006316 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 218494006317 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 218494006318 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 218494006319 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 218494006320 binding surface 218494006321 TPR motif; other site 218494006322 HMMPfam hit to PF00515, Tetratricopeptide TPR-1, score 2.4e-06 218494006323 Domain of unknown function DUF20; Region: UPF0118; cl00465 218494006324 HMMPfam hit to PF01594, Protein of unknown function UPF0118, score 1e-79 218494006325 8 probable transmembrane helices predicted for SSU1314 by TMHMM2.0 at aa 20-42, 52-74, 91-113, 180-202, 247-269, 284-306, 319-341 and 346-365 218494006326 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 218494006327 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 218494006328 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218494006329 motif II; other site 218494006330 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 7.1e-20 218494006331 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 218494006332 HMMPfam hit to PF05016, Plasmid stabilization system, score 3.1e-16 218494006333 enolase; Provisional; Region: eno; PRK00077 218494006334 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 218494006335 dimer interface [polypeptide binding]; other site 218494006336 metal binding site [ion binding]; metal-binding site 218494006337 substrate binding pocket [chemical binding]; other site 218494006338 HMMPfam hit to PF00113, Enolase, score 6.4e-165 218494006339 PS00164 Enolase signature. 218494006340 HMMPfam hit to PF03952, Enolase, score 2.8e-68 218494006341 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 218494006342 HMMPfam hit to PF07997, Protein of unknown function DUF1694, score 1e-29 218494006343 Glycerate kinase family; Region: Gly_kinase; cl00841 218494006344 HMMPfam hit to PF02595, Glycerate kinase, score 1.8e-92 218494006345 PS00017 ATP/GTP-binding site motif A (P-loop). 218494006346 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 218494006347 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 218494006348 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218494006349 motif II; other site 218494006350 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1.5e-24 218494006351 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 218494006352 Transposase; Region: DEDD_Tnp_IS110; pfam01548 218494006353 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 218494006354 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 1.2e-20 218494006355 HMMPfam hit to PF01548, Transposase, IS111A/IS1328/IS1533, score 0.00011 218494006356 phosphoserine phosphatase SerB; Region: serB; TIGR00338 218494006357 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218494006358 motif II; other site 218494006359 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 4.1e-23 218494006360 septation ring formation regulator EzrA; Provisional; Region: PRK04778 218494006361 HMMPfam hit to PF06160, Septation ring formation regulator, EzrA, score 2.4e-258 218494006362 1 probable transmembrane helix predicted for SSU1326 by TMHMM2.0 at aa 7-26 218494006363 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 218494006364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218494006365 Mg2+ binding site [ion binding]; other site 218494006366 G-X-G motif; other site 218494006367 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 218494006368 anchoring element; other site 218494006369 dimer interface [polypeptide binding]; other site 218494006370 ATP binding site [chemical binding]; other site 218494006371 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 218494006372 active site 218494006373 putative metal-binding site [ion binding]; other site 218494006374 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 218494006375 HMMPfam hit to PF00986, DNA topoisomerase, type IIA, subunit B, C-terminal, score 3.1e-48 218494006376 HMMPfam hit to PF01751, TOPRIM, score 1.7e-07 218494006377 PS00177 DNA topoisomerase II signature. 218494006378 HMMPfam hit to PF00204, DNA topoisomerase, type IIA, subunit B, region 2, score 1.8e-99 218494006379 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 1.8e-29 218494006380 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 218494006381 conserved cys residue [active] 218494006382 HMMPfam hit to PF01965, ThiJ/PfpI, score 9.1e-26 218494006383 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 218494006384 HMMPfam hit to PF01098, Cell cycle protein, score 4.6e-78 218494006385 10 probable transmembrane helices predicted for SSU1329 by TMHMM2.0 at aa 17-39, 54-76, 81-103, 118-140, 153-172, 176-197, 204-226, 292-314, 327-349 and 364-386 218494006386 phage related genomic island 218494006387 INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186 218494006388 Phage integrase family; Region: Phage_integrase; pfam00589 218494006389 Int/Topo IB signature motif; other site 218494006390 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 2.2e-19 218494006391 D5 N terminal like; Region: D5_N; cl07360 218494006392 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 218494006393 HMMPfam hit to PF03288, DNA primase/nucleoside triphosphatase, C-terminal, score 0.00011 218494006394 HMMPfam hit to PF08706, Phage_plasmid primase, P4, C-terminal, score 0.001 218494006395 1 probable transmembrane helix predicted for SSU1335 by TMHMM2.0 at aa 10-32 218494006396 Predicted helix-turn-helix motif with score 1171.000, SD 3.18 at aa 28-49, sequence ITARHIAQQTNLDKRTVRECVR 218494006397 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494006398 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 1.8e-05 218494006399 Predicted helix-turn-helix motif with score 1795.000, SD 5.30 at aa 20-41, sequence LTKKATAEKLGIKPQTLTKVEQ 218494006400 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 218494006401 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218494006402 non-specific DNA binding site [nucleotide binding]; other site 218494006403 salt bridge; other site 218494006404 sequence-specific DNA binding site [nucleotide binding]; other site 218494006405 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 8.7e-20 218494006406 Predicted helix-turn-helix motif with score 2255.000, SD 6.87 at aa 13-34, sequence LTQEELAKKIGVNLRTLQKWEN 218494006407 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 218494006408 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 218494006409 Phage integrase family; Region: Phage_integrase; pfam00589 218494006410 Int/Topo IB signature motif; other site 218494006411 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 6.3e-35 218494006412 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 218494006413 HMMPfam hit to PF01197, Ribosomal protein L31, score 3.3e-22 218494006414 PS01143 Ribosomal protein L31 signature. 218494006415 ApbE family; Region: ApbE; cl00643 218494006416 HMMPfam hit to PF02424, ApbE-like lipoprotein, score 8.5e-40 218494006417 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 218494006418 DHH family; Region: DHH; pfam01368 218494006419 HMMPfam hit to PF02272, Phosphoesterase, DHHA1, score 2.2e-06 218494006420 HMMPfam hit to PF01368, Phosphoesterase, RecJ-like, score 7.5e-45 218494006421 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 218494006422 HMMPfam hit to PF00258, Flavodoxin/nitric oxide synthase, score 1.7e-20 218494006423 PS00201 Flavodoxin signature. 218494006424 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 218494006425 HMMPfam hit to PF00253, Ribosomal protein S14, score 5.6e-14 218494006426 Chorismate mutase type II; Region: CM_2; cl00693 218494006427 HMMPfam hit to PF01817, Chorismate mutase, score 1.2e-25 218494006428 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 218494006429 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 218494006430 Cl- selectivity filter; other site 218494006431 Cl- binding residues [ion binding]; other site 218494006432 pore gating glutamate residue; other site 218494006433 dimer interface [polypeptide binding]; other site 218494006434 10 probable transmembrane helices predicted for SSU1354 by TMHMM2.0 at aa 12-34, 44-61, 146-168, 173-195, 215-234, 244-266, 287-309, 313-332, 337-359 and 363-382 218494006435 HMMPfam hit to PF00654, Chloride channel, core, score 1.7e-08 218494006436 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 218494006437 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 218494006438 putative active site [active] 218494006439 putative metal binding site [ion binding]; other site 218494006440 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 218494006441 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 2.7e-05 218494006442 HMMPfam hit to PF02872, 5'-Nucleotidase, C-terminal, score 1.9e-40 218494006443 HMMPfam hit to PF00149, Metallophosphoesterase, score 2.2e-10 218494006444 1 probable transmembrane helix predicted for SSU1355 by TMHMM2.0 at aa 13-30 218494006445 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 218494006446 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 218494006447 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 218494006448 HMMPfam hit to PF02777, Manganese and iron superoxide dismutase, score 3.2e-72 218494006449 PS00088 Manganese and iron superoxide dismutases signature. 218494006450 HMMPfam hit to PF00081, Manganese and iron superoxide dismutase, score 8.5e-42 218494006451 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 218494006452 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 218494006453 HMMPfam hit to PF06144, DNA polymerase III, delta, score 4.9e-113 218494006454 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 218494006455 HMMPfam hit to PF02677, Protein of unknown function DUF208, score 4.4e-50 218494006456 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 218494006457 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 218494006458 Walker A/P-loop; other site 218494006459 ATP binding site [chemical binding]; other site 218494006460 Q-loop/lid; other site 218494006461 ABC transporter signature motif; other site 218494006462 Walker B; other site 218494006463 D-loop; other site 218494006464 H-loop/switch region; other site 218494006465 HMMPfam hit to PF00005, ABC transporter related, score 9.4e-50 218494006466 PS00211 ABC transporters family signature. 218494006467 PS00017 ATP/GTP-binding site motif A (P-loop). 218494006468 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 218494006469 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 218494006470 Walker A/P-loop; other site 218494006471 ATP binding site [chemical binding]; other site 218494006472 Q-loop/lid; other site 218494006473 ABC transporter signature motif; other site 218494006474 Walker B; other site 218494006475 D-loop; other site 218494006476 H-loop/switch region; other site 218494006477 HMMPfam hit to PF00005, ABC transporter related, score 3.5e-57 218494006478 PS00017 ATP/GTP-binding site motif A (P-loop). 218494006479 PS00017 ATP/GTP-binding site motif A (P-loop). 218494006480 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 218494006481 TM-ABC transporter signature motif; other site 218494006482 8 probable transmembrane helices predicted for SSU1362 by TMHMM2.0 at aa 7-29, 44-66, 87-109, 119-141, 153-175, 205-227, 240-262 and 277-299 218494006483 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 9.9e-40 218494006484 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 218494006485 TM-ABC transporter signature motif; other site 218494006486 8 probable transmembrane helices predicted for SSU1363 by TMHMM2.0 at aa 7-29, 39-57, 64-86, 96-118, 139-161, 191-213, 232-254 and 269-288 218494006487 HMMPfam hit to PF02653, Bacterial inner-membrane translocator, score 1.5e-42 218494006488 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 218494006489 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 218494006490 putative ligand binding site [chemical binding]; other site 218494006491 HMMPfam hit to PF01094, Extracellular ligand-binding receptor, score 6.5e-43 218494006492 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494006493 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 218494006494 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 218494006495 oligomer interface [polypeptide binding]; other site 218494006496 active site residues [active] 218494006497 HMMPfam hit to PF00574, Peptidase S14, ClpP, score 2.1e-117 218494006498 PS00382 Endopeptidase Clp histidine active site. 218494006499 PS00381 Endopeptidase Clp serine active site. 218494006500 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 218494006501 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 2.3e-14 218494006502 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 218494006503 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 218494006504 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 1.4e-126 218494006505 sucrose phosphorylase; Provisional; Region: PRK13840 218494006506 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 218494006507 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 0.0015 218494006508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 218494006509 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 218494006510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494006511 dimer interface [polypeptide binding]; other site 218494006512 conserved gate region; other site 218494006513 putative PBP binding loops; other site 218494006514 ABC-ATPase subunit interface; other site 218494006515 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 5.5e-21 218494006516 6 probable transmembrane helices predicted for SSU1370 by TMHMM2.0 at aa 9-31, 72-94, 101-123, 138-160, 186-208 and 245-262 218494006517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494006518 dimer interface [polypeptide binding]; other site 218494006519 conserved gate region; other site 218494006520 putative PBP binding loops; other site 218494006521 ABC-ATPase subunit interface; other site 218494006522 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 4.7e-19 218494006523 6 probable transmembrane helices predicted for SSU1371 by TMHMM2.0 at aa 12-34, 74-96, 109-131, 156-178, 207-229 and 262-281 218494006524 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218494006525 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 218494006526 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218494006527 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 2.4e-30 218494006528 PS01037 Bacterial extracellular solute-binding proteins, family 1 signature. 218494006529 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494006530 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 218494006531 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 218494006532 HMMPfam hit to PF02065, Glycoside hydrolase, clan GH-D, score 2.9e-236 218494006533 PS00512 Alpha-galactosidase signature. 218494006534 Cupin domain; Region: Cupin_2; cl09118 218494006535 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 218494006536 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218494006537 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218494006538 HMMPfam hit to PF02311, AraC protein, arabinose-binding/dimerisation, score 5.3e-21 218494006539 PS00904 Protein prenyltransferases alpha subunit repeat signature. 218494006540 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 1.6e-12 218494006541 Predicted helix-turn-helix motif with score 1471.000, SD 4.20 at aa 242-263, sequence IKVSEIADFLALSRSYLYKIFK 218494006542 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 4.9e-11 218494006543 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 218494006544 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218494006545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218494006546 homodimer interface [polypeptide binding]; other site 218494006547 catalytic residue [active] 218494006548 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 1.6e-22 218494006549 cystathionine gamma-synthase; Reviewed; Region: PRK07269 218494006550 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 218494006551 homodimer interface [polypeptide binding]; other site 218494006552 substrate-cofactor binding pocket; other site 218494006553 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218494006554 catalytic residue [active] 218494006555 HMMPfam hit to PF01053, Cys/Met metabolism, pyridoxal phosphate-dependent enzyme, score 9e-174 218494006556 PS00868 Cys/Met metabolism enzymes pyridoxal-phosphate attachment site. 218494006557 3 probable transmembrane helices predicted for SSU1377 by TMHMM2.0 at aa 12-34, 39-61 and 73-90 218494006558 3 probable transmembrane helices predicted for SSU1378 by TMHMM2.0 at aa 13-30, 35-54 and 66-83 218494006559 3 probable transmembrane helices predicted for SSU1379 by TMHMM2.0 at aa 13-30, 35-54 and 63-82 218494006560 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 218494006561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218494006562 S-adenosylmethionine binding site [chemical binding]; other site 218494006563 HMMPfam hit to PF05175, Methyltransferase small, score 1.3e-06 218494006564 PS00092 N-6 Adenine-specific DNA methylases signature. 218494006565 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 218494006566 GIY-YIG motif/motif A; other site 218494006567 putative active site [active] 218494006568 putative metal binding site [ion binding]; other site 218494006569 HMMPfam hit to PF01541, Excinuclease ABC, C subunit, N-terminal, score 8.4e-19 218494006570 Ion channel; Region: Ion_trans_2; cl11596 218494006571 3 probable transmembrane helices predicted for SSU1382 by TMHMM2.0 at aa 21-43, 53-75 and 80-102 218494006572 HMMPfam hit to PF07885, Ion transport 2, score 8e-15 218494006573 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 218494006574 HMMPfam hit to PF02525, Flavodoxin-like fold, score 5e-36 218494006575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218494006576 Coenzyme A binding pocket [chemical binding]; other site 218494006577 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 7e-14 218494006578 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 218494006579 6 probable transmembrane helices predicted for SSU1385 by TMHMM2.0 at aa 9-31, 51-72, 85-107, 112-131, 152-169 and 174-193 218494006580 HMMPfam hit to PF07853, Protein of unknown function DUF1648, score 1.1e-12 218494006581 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 218494006582 dimerization interface [polypeptide binding]; other site 218494006583 putative DNA binding site [nucleotide binding]; other site 218494006584 putative Zn2+ binding site [ion binding]; other site 218494006585 HMMPfam hit to PF01022, Bacterial regulatory protein, ArsR, score 2.8e-15 218494006586 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 218494006587 DEAD-like helicases superfamily; Region: DEXDc; smart00487 218494006588 ATP binding site [chemical binding]; other site 218494006589 Mg++ binding site [ion binding]; other site 218494006590 motif III; other site 218494006591 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218494006592 nucleotide binding region [chemical binding]; other site 218494006593 ATP-binding site [chemical binding]; other site 218494006594 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 5.8e-37 218494006595 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 2.7e-77 218494006596 PS00039 DEAD-box subfamily ATP-dependent helicases signature. 218494006597 PS00017 ATP/GTP-binding site motif A (P-loop). 218494006598 Probable gene remnant. CDS is truncated at the C-terminus in comparison to orthologues. Similar to the N-terminal region of Listeria monocytogenes LMO1252 protein UniProt:Q8Y7M2 (EMBL:AL591978) (282 aa) fasta scores: E()=2.8e-20, 38.202% id in 178 aa 218494006599 HMMPfam hit to PF02588, Protein of unknown function DUF161, score 1.8e-12 218494006600 5 probable transmembrane helices predicted for SSU1388 by TMHMM2.0 at aa 9-28, 43-65, 74-93, 103-125 and 146-168 218494006601 HMMPfam hit to PF02588, Protein of unknown function DUF161, score 4.8e-19 218494006602 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 218494006603 HMMPfam hit to PF08000, Protein of unknown function DUF1696, score 4.4e-79 218494006604 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 218494006605 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 218494006606 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 218494006607 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 218494006608 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 218494006609 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 218494006610 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 218494006611 Leucine-rich repeats; other site 218494006612 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 218494006613 Substrate binding site [chemical binding]; other site 218494006614 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 218494006615 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 218494006616 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 218494006617 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12880 218494006618 HMMPfam hit to PF00560, Leucine-rich repeat, score 4.7 218494006619 HMMPfam hit to PF00560, Leucine-rich repeat, score 0.031 218494006620 HMMPfam hit to PF04270, Streptococcal histidine triad, score 0.049 218494006621 HMMPfam hit to PF04270, Streptococcal histidine triad, score 0.028 218494006622 HMMPfam hit to PF04270, Streptococcal histidine triad, score 3.3e-08 218494006623 HMMPfam hit to PF04270, Streptococcal histidine triad, score 0.002 218494006624 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494006625 1 probable transmembrane helix predicted for SSU1391 by TMHMM2.0 at aa 21-43 218494006626 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494006627 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 218494006628 4 probable transmembrane helices predicted for SSU1392 by TMHMM2.0 at aa 12-31, 71-93, 106-128 and 143-165 218494006629 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218494006630 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 218494006631 dimer interface [polypeptide binding]; other site 218494006632 pyridoxal binding site [chemical binding]; other site 218494006633 ATP binding site [chemical binding]; other site 218494006634 HMMPfam hit to PF08543, Phosphomethylpyrimidine kinase type-1, score 9.1e-05 218494006635 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 218494006636 HMMPfam hit to PF01048, Nucleoside phosphorylase, score 1.6e-57 218494006637 1 probable transmembrane helix predicted for SSU1395 by TMHMM2.0 at aa 88-105 218494006638 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 218494006639 dimer interface [polypeptide binding]; other site 218494006640 ADP-ribose binding site [chemical binding]; other site 218494006641 active site 218494006642 nudix motif; other site 218494006643 metal binding site [ion binding]; metal-binding site 218494006644 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 3.9e-26 218494006645 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 218494006646 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 218494006647 Substrate binding site; other site 218494006648 Mg++ binding site; other site 218494006649 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 218494006650 active site 218494006651 substrate binding site [chemical binding]; other site 218494006652 CoA binding site [chemical binding]; other site 218494006653 PS00101 Hexapeptide-repeat containing-transferases signature. 218494006654 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.78 218494006655 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 1.1 218494006656 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 21 218494006657 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 23 218494006658 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.9 218494006659 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 9.5 218494006660 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.31 218494006661 HMMPfam hit to PF01128, 4-diphosphocytidyl-2C-methyl-D-erythritol synthase, score 1.7e-08 218494006662 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 218494006663 HMMPfam hit to PF06171, Protein of unknown function DUF984, score 1.5e-58 218494006664 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 218494006665 classical (c) SDRs; Region: SDR_c; cd05233 218494006666 NAD(P) binding site [chemical binding]; other site 218494006667 active site 218494006668 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 3.5e-15 218494006669 PS00061 Short-chain dehydrogenases/reductases family signature. 218494006670 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 218494006671 PS00430 TonB-dependent receptor proteins signature 1. 218494006672 6 probable transmembrane helices predicted for SSU1402 by TMHMM2.0 at aa 98-120, 124-146, 158-180, 195-212, 217-239 and 244-266 218494006673 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494006674 HMMPfam hit to PF03551, Transcriptional regulator PadR-like, score 1.4e-32 218494006675 1 probable transmembrane helix predicted for SSU1404 by TMHMM2.0 at aa 13-47 218494006676 Transposase IS200 like; Region: Y1_Tnp; cl00848 218494006677 HMMPfam hit to PF01797, Transposase IS200-like, score 1.2e-58 218494006678 10 probable transmembrane helices predicted for SSU1406 by TMHMM2.0 at aa 20-42, 55-77, 106-128, 155-177, 197-219, 234-256, 282-304, 545-567, 601-620 and 635-657 218494006679 HMMPfam hit to PF02687, Protein of unknown function DUF214, permase predicted, score 0.00054 218494006680 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 218494006681 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 218494006682 Walker A/P-loop; other site 218494006683 ATP binding site [chemical binding]; other site 218494006684 Q-loop/lid; other site 218494006685 ABC transporter signature motif; other site 218494006686 Walker B; other site 218494006687 D-loop; other site 218494006688 H-loop/switch region; other site 218494006689 HMMPfam hit to PF00005, ABC transporter related, score 2.1e-61 218494006690 PS00211 ABC transporters family signature. 218494006691 PS00017 ATP/GTP-binding site motif A (P-loop). 218494006692 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 218494006693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218494006694 ATP binding site [chemical binding]; other site 218494006695 Mg2+ binding site [ion binding]; other site 218494006696 G-X-G motif; other site 218494006697 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 7.8e-26 218494006698 2 probable transmembrane helices predicted for SSU1408 by TMHMM2.0 at aa 20-42 and 47-69 218494006699 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 218494006700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218494006701 active site 218494006702 phosphorylation site [posttranslational modification] 218494006703 intermolecular recognition site; other site 218494006704 dimerization interface [polypeptide binding]; other site 218494006705 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218494006706 DNA binding site [nucleotide binding] 218494006707 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 8.9e-23 218494006708 HMMPfam hit to PF00072, Response regulator receiver, score 8.2e-32 218494006709 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 218494006710 transaminase; Validated; Region: PRK07324 218494006711 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 218494006712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218494006713 homodimer interface [polypeptide binding]; other site 218494006714 catalytic residue [active] 218494006715 HMMPfam hit to PF00155, Aminotransferase, class I and II, score 3.4e-32 218494006716 PS00105 Aminotransferases class-I pyridoxal-phosphate attachment site. 218494006717 Predicted helix-turn-helix motif with score 1003.000, SD 2.60 at aa 31-52, sequence LTLEELFALSGTNPEDFYKKLQ 218494006718 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 218494006719 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 218494006720 HMMPfam hit to PF07366, Protein of unknown function DUF1486, score 8.7e-08 218494006721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494006722 dimer interface [polypeptide binding]; other site 218494006723 conserved gate region; other site 218494006724 putative PBP binding loops; other site 218494006725 ABC-ATPase subunit interface; other site 218494006726 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 218494006727 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 218494006728 HMMPfam hit to PF04069, Substrate-binding region of ABC-type glycine betaine transport system, score 5.4e-84 218494006729 PS00017 ATP/GTP-binding site motif A (P-loop). 218494006730 5 probable transmembrane helices predicted for SSU1413 by TMHMM2.0 at aa 21-43, 71-93, 146-168, 178-200 and 207-229 218494006731 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 3.6e-21 218494006732 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 218494006733 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494006734 Walker A/P-loop; other site 218494006735 ATP binding site [chemical binding]; other site 218494006736 Q-loop/lid; other site 218494006737 ABC transporter signature motif; other site 218494006738 Walker B; other site 218494006739 D-loop; other site 218494006740 H-loop/switch region; other site 218494006741 HMMPfam hit to PF00005, ABC transporter related, score 3.9e-63 218494006742 PS00211 ABC transporters family signature. 218494006743 PS00017 ATP/GTP-binding site motif A (P-loop). 218494006744 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494006745 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 1.3e-08 218494006746 1 probable transmembrane helix predicted for SSU1416 by TMHMM2.0 at aa 5-27 218494006747 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 218494006748 HMMPfam hit to PF06103, Protein of unknown function DUF948, bacterial, score 4.7e-43 218494006749 1 probable transmembrane helix predicted for SSU1417 by TMHMM2.0 at aa 5-24 218494006750 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 218494006751 HMMPfam hit to PF01790, Prolipoprotein diacylglyceryl transferase, score 1.3e-124 218494006752 5 probable transmembrane helices predicted for SSU1418 by TMHMM2.0 at aa 13-32, 45-67, 82-104, 196-213 and 228-246 218494006753 PS01311 Prolipoprotein diacylglyceryl transferase signature. 218494006754 HPr kinase/phosphorylase; Provisional; Region: PRK05428 218494006755 DRTGG domain; Region: DRTGG; cl12147 218494006756 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 218494006757 Hpr binding site; other site 218494006758 active site 218494006759 homohexamer subunit interaction site [polypeptide binding]; other site 218494006760 HMMPfam hit to PF07475, HPr Serine kinase, C-terminal, score 4.5e-74 218494006761 PS00017 ATP/GTP-binding site motif A (P-loop). 218494006762 HMMPfam hit to PF02603, HPr Serine kinase, N-terminal, score 2.4e-29 218494006763 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 218494006764 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 218494006765 HMMPfam hit to PF01238, Mannose-6-phosphate isomerase, type I, score 7.5e-101 218494006766 Transposase; Region: HTH_Tnp_IS630; pfam01710 218494006767 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 218494006768 HMMPfam hit to PF01710, Transposase, Synechocystis PCC 6803, score 6.5e-16 218494006769 Predicted helix-turn-helix motif with score 2164.000, SD 6.56 at aa 19-40, sequence GSITEASAIFQVSRNTIYQWLK 218494006770 Integrase core domain; Region: rve; cl01316 218494006771 hypothetical protein; Provisional; Region: PRK04351 218494006772 SprT homologues; Region: SprT; cl01182 218494006773 HMMPfam hit to PF03926, Protein of unknown function DUF335, SprT, score 1e-63 218494006774 Probable gene remnant. Similar to the C_terminal region of Streptococcus thermophilus (strain ATCC BAA-250/LMG 18311) tex transcriptional regulator, . UniProt:Q5M536 (EMBL:CP000023) (710 aa) fasta scores: E()=1.8e-71, 74.286% id in 315 aa 218494006775 HMMPfam hit to PF00575, S1, RNA binding, score 4.6e-12 218494006776 Predicted helix-turn-helix motif with score 1304.000, SD 3.63 at aa 189-210, sequence LAIADTAEKIGVGQETLKDIIA 218494006777 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 218494006778 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 218494006779 active site 218494006780 catalytic tetrad [active] 218494006781 HMMPfam hit to PF00248, Aldo/keto reductase, score 3.5e-101 218494006782 PS00062 Aldo/keto reductase family signature 2. 218494006783 PS00798 Aldo/keto reductase family signature 1. 218494006784 QueT transporter; Region: QueT; cl01932 218494006785 HMMPfam hit to PF06177, Protein of unknown function DUF988, score 7.2e-100 218494006786 5 probable transmembrane helices predicted for SSU1428 by TMHMM2.0 at aa 15-37, 50-72, 77-94, 106-128 and 138-160 218494006787 GtrA-like protein; Region: GtrA; cl00971 218494006788 4 probable transmembrane helices predicted for SSU1429 by TMHMM2.0 at aa 13-32, 36-58, 79-98 and 113-135 218494006789 HMMPfam hit to PF04138, GtrA-like protein, score 6e-10 218494006790 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 218494006791 HMMPfam hit to PF03631, Ribonuclease BN, score 4.6e-58 218494006792 6 probable transmembrane helices predicted for SSU1430 by TMHMM2.0 at aa 31-53, 90-112, 133-155, 181-203, 210-232 and 247-269 218494006793 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 218494006794 active site 218494006795 HMMPfam hit to PF00557, Peptidase M24, catalytic core, score 1.4e-45 218494006796 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 218494006797 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 218494006798 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 4e-08 218494006799 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 218494006800 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 218494006801 hinge; other site 218494006802 active site 218494006803 HMMPfam hit to PF00275, 3-phosphoshikimate 1-carboxyvinyltransferase, score 6.8e-96 218494006804 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 218494006805 HMMPfam hit to PF02525, Flavodoxin-like fold, score 4.2e-37 218494006806 S-adenosylmethionine synthetase; Validated; Region: PRK05250 218494006807 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 218494006808 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 218494006809 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 218494006810 HMMPfam hit to PF02773, S-adenosylmethionine synthetase, score 2.5e-88 218494006811 PS00377 S-adenosylmethionine synthetase signature 2. 218494006812 HMMPfam hit to PF02772, S-adenosylmethionine synthetase, score 2.4e-82 218494006813 PS00376 S-adenosylmethionine synthetase signature 1. 218494006814 HMMPfam hit to PF00438, S-adenosylmethionine synthetase, score 7.1e-48 218494006815 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 218494006816 catalytic motif [active] 218494006817 Zn binding site [ion binding]; other site 218494006818 HMMPfam hit to PF00383, CMP/dCMP deaminase, zinc-binding, score 1e-28 218494006819 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 218494006820 Predicted transcriptional regulator with C-terminal CBS domains [Transcription]; Region: COG3620 218494006821 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 1.2e-06 218494006822 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 218494006823 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 218494006824 putative oligomer interface [polypeptide binding]; other site 218494006825 putative active site [active] 218494006826 metal binding site [ion binding]; metal-binding site 218494006827 HMMPfam hit to PF05343, Peptidase M42, score 7e-115 218494006828 PS00012 Phosphopantetheine attachment site. 218494006829 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 218494006830 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 218494006831 DNA-binding site [nucleotide binding]; DNA binding site 218494006832 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 218494006833 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 218494006834 HMMPfam hit to PF08279, Helix-turn-helix, type 11, score 3.9e-20 218494006835 Predicted helix-turn-helix motif with score 1735.000, SD 5.10 at aa 18-39, sequence VSGEDLAQELGISRTSIWKAIR 218494006836 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase, score 1.3e-06 218494006837 HMMPfam hit to PF02237, Biotin protein ligase, C-terminal, score 2.1e-07 218494006838 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 218494006839 1 probable transmembrane helix predicted for SSU1440 by TMHMM2.0 at aa 15-37 218494006840 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 218494006841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218494006842 Walker A motif; other site 218494006843 ATP binding site [chemical binding]; other site 218494006844 Walker B motif; other site 218494006845 arginine finger; other site 218494006846 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 218494006847 HMMPfam hit to PF00004, AAA ATPase, core, score 7.5e-15 218494006848 PS00017 ATP/GTP-binding site motif A (P-loop). 218494006849 GAF domain; Region: GAF; cl00853 218494006850 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 218494006851 3 probable transmembrane helices predicted for SSU1443 by TMHMM2.0 at aa 7-25, 40-57 and 69-88 218494006852 HMMPfam hit to PF06961, Protein of unknown function DUF1294, score 2.6e-28 218494006853 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494006854 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 218494006855 HMMPfam hit to PF03551, Transcriptional regulator PadR-like, score 3.6e-05 218494006856 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 218494006857 Sugar specificity; other site 218494006858 Pyrimidine base specificity; other site 218494006859 ATP-binding site [chemical binding]; other site 218494006860 HMMPfam hit to PF00485, Phosphoribulokinase/uridine kinase, score 2e-52 218494006861 PS00017 ATP/GTP-binding site motif A (P-loop). 218494006862 CDS contains a nonsense mutation (opal) after codon 226. Similar to Streptococcus pneumoniae Gfo/Idh/MocA family oxidoreductase UniProt:Q97PV8 (EMBL:AE007444) (325 aa) fasta scores: E()=1.3e-67, 59.568% id in 324 aa 218494006863 HMMPfam hit to PF01408, Oxidoreductase, N-terminal, score 2.8e-28 218494006864 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494006865 DEAD-like helicases superfamily; Region: DEXDc; smart00487 218494006866 ATP binding site [chemical binding]; other site 218494006867 putative Mg++ binding site [ion binding]; other site 218494006868 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218494006869 nucleotide binding region [chemical binding]; other site 218494006870 ATP-binding site [chemical binding]; other site 218494006871 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 3.1e-44 218494006872 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 4.7e-25 218494006873 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 218494006874 HMMPfam hit to PF01522, Polysaccharide deacetylase, score 9.2e-51 218494006875 1 probable transmembrane helix predicted for SSU1448 by TMHMM2.0 at aa 7-29 218494006876 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 218494006877 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 218494006878 dimer interface [polypeptide binding]; other site 218494006879 active site 218494006880 metal binding site [ion binding]; metal-binding site 218494006881 glutathione binding site [chemical binding]; other site 218494006882 HMMPfam hit to PF00903, Glyoxalase/bleomycin resistance protein/dioxygenase, score 4.3e-24 218494006883 CDS contains a frameshift after codon 16 and an insertion and frameshift after codon 129. Similar to Photorhabdus luminescens subsp. laumondii ISPlu5A IS200 family transposase UniProt:Q7MYQ8 (EMBL:BX571874) (151 aa) fasta scores: E()=1.1e-44, 76.000% id in 150 aa 218494006884 extra DNA in comparison to IS elements of the same family 218494006885 HMMPfam hit to PF01797, Transposase IS200-like, score 2.6e-57 218494006886 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 218494006887 catalytic core [active] 218494006888 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 218494006889 HMMPfam hit to PF00300, Phosphoglycerate mutase, score 8.8e-46 218494006890 putative acyltransferase; Provisional; Region: PRK05790 218494006891 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 218494006892 dimer interface [polypeptide binding]; other site 218494006893 active site 218494006894 HMMPfam hit to PF00108, Thiolase, score 1.5e-138 218494006895 PS00098 Thiolases acyl-enzyme intermediate signature. 218494006896 HMMPfam hit to PF02803, Thiolase, score 2.2e-75 218494006897 PS00737 Thiolases signature 2. 218494006898 PS00099 Thiolases active site. 218494006899 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 218494006900 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 218494006901 dimer interface [polypeptide binding]; other site 218494006902 active site 218494006903 HMMPfam hit to PF01154, Hydroxymethylglutaryl-coenzyme A synthase, N-terminal, score 9.2e-16 218494006904 HMMPfam hit to PF08540, Hydroxymethylglutaryl-coenzyme A synthase C-terminal, score 4.7e-11 218494006905 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 218494006906 homodimer interface [polypeptide binding]; other site 218494006907 NAD binding site [chemical binding]; other site 218494006908 catalytic residues [active] 218494006909 substrate binding pocket [chemical binding]; other site 218494006910 flexible flap; other site 218494006911 Transposase; Region: DEDD_Tnp_IS110; pfam01548 218494006912 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 218494006913 HMMPfam hit to PF01548, Transposase, IS111A/IS1328/IS1533, score 1.2e-11 218494006914 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 8.2e-24 218494006915 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 218494006916 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218494006917 Coenzyme A binding pocket [chemical binding]; other site 218494006918 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.1e-20 218494006919 Transposase; Region: DEDD_Tnp_IS110; pfam01548 218494006920 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 218494006921 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 218494006922 HMMPfam hit to PF01548, Transposase, IS111A/IS1328/IS1533, score 7e-05 218494006923 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 1.2e-20 218494006924 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 218494006925 IHF dimer interface [polypeptide binding]; other site 218494006926 IHF - DNA interface [nucleotide binding]; other site 218494006927 HMMPfam hit to PF00216, Histone-like bacterial DNA-binding protein, score 9.3e-51 218494006928 PS00045 Bacterial histone-like DNA-binding proteins signature. 218494006929 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 218494006930 1 probable transmembrane helix predicted for SSU1459 by TMHMM2.0 at aa 12-34 218494006931 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494006932 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 218494006933 active site 218494006934 catalytic triad [active] 218494006935 oxyanion hole [active] 218494006936 HMMPfam hit to PF00657, Lipolytic enzyme, G-D-S-L, score 6.4e-21 218494006937 1 probable transmembrane helix predicted for SSU1460 by TMHMM2.0 at aa 15-37 218494006938 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 218494006939 HMMPfam hit to PF02645, DegV, score 4e-74 218494006940 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 218494006941 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 218494006942 Walker A/P-loop; other site 218494006943 ATP binding site [chemical binding]; other site 218494006944 Q-loop/lid; other site 218494006945 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 218494006946 ABC transporter signature motif; other site 218494006947 Walker B; other site 218494006948 D-loop; other site 218494006949 H-loop/switch region; other site 218494006950 HMMPfam hit to PF02463, SMC protein, N-terminal, score 1.4e-09 218494006951 PS00017 ATP/GTP-binding site motif A (P-loop). 218494006952 Arginine repressor [Transcription]; Region: ArgR; COG1438 218494006953 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 218494006954 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 218494006955 HMMPfam hit to PF02863, Arginine repressor, score 2.3e-15 218494006956 HMMPfam hit to PF01316, Arginine repressor, score 2.1e-25 218494006957 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 218494006958 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 218494006959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 218494006960 HMMPfam hit to PF01728, Ribosomal RNA methyltransferase RrmJ/FtsJ, score 2.3e-05 218494006961 HMMPfam hit to PF01479, RNA-binding S4, score 4.7e-05 218494006962 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 218494006963 substrate binding pocket [chemical binding]; other site 218494006964 chain length determination region; other site 218494006965 substrate-Mg2+ binding site; other site 218494006966 catalytic residues [active] 218494006967 aspartate-rich region 1; other site 218494006968 active site lid residues [active] 218494006969 aspartate-rich region 2; other site 218494006970 HMMPfam hit to PF00348, Polyprenyl synthetase, score 7.6e-77 218494006971 PS00444 Polyprenyl synthetases signature 2. 218494006972 PS00723 Polyprenyl synthetases signature 1. 218494006973 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 218494006974 HMMPfam hit to PF02609, Exonuclease VII, small subunit, score 4.3e-27 218494006975 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 218494006976 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 218494006977 generic binding surface II; other site 218494006978 generic binding surface I; other site 218494006979 HMMPfam hit to PF02601, Exonuclease VII, large subunit, score 1.2e-48 218494006980 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 4.2e-14 218494006981 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 218494006982 HMMPfam hit to PF04228, Protein of unknown function, zinc metallopeptidase , score 3.9e-168 218494006983 1 probable transmembrane helix predicted for SSU1468 by TMHMM2.0 at aa 49-68 218494006984 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218494006985 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 218494006986 HMMPfam hit to PF04140, Isoprenylcysteine carboxyl methyltransferase, score 8e-38 218494006987 4 probable transmembrane helices predicted for SSU1470 by TMHMM2.0 at aa 2-21, 43-60, 67-89 and 129-151 218494006988 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 218494006989 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 218494006990 dimer interface [polypeptide binding]; other site 218494006991 phosphorylation site [posttranslational modification] 218494006992 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218494006993 ATP binding site [chemical binding]; other site 218494006994 Mg2+ binding site [ion binding]; other site 218494006995 G-X-G motif; other site 218494006996 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 7.3e-11 218494006997 HMMPfam hit to PF00512, Histidine kinase A, N-terminal, score 2e-07 218494006998 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 1.7e-09 218494006999 2 probable transmembrane helices predicted for SSU1471 by TMHMM2.0 at aa 7-29 and 145-167 218494007000 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 218494007001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218494007002 active site 218494007003 phosphorylation site [posttranslational modification] 218494007004 intermolecular recognition site; other site 218494007005 dimerization interface [polypeptide binding]; other site 218494007006 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218494007007 DNA binding site [nucleotide binding] 218494007008 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 4.9e-20 218494007009 HMMPfam hit to PF00072, Response regulator receiver, score 8.5e-33 218494007010 6 probable transmembrane helices predicted for SSU1473 by TMHMM2.0 at aa 15-37, 58-75, 95-116, 137-159, 179-201 and 210-232 218494007011 HMMPfam hit to PF02517, Abortive infection protein, score 0.033 218494007012 CDS contains frameshifts after codons 48 and 88. First frameshift occurs at a poly A octamer. Similar to Streptococcus pyogenes serum opacity factor SOF63 UniProt:Q9L953 (EMBL:AF181974) (1013 aa) fasta scores: E()=3e-50, 31.668% id in 1001 aa 218494007013 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 6.8e-07 218494007014 PS00430 TonB-dependent receptor proteins signature 1. 218494007015 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 9.7e-05 218494007016 2 probable transmembrane helices predicted for SSU1476 by TMHMM2.0 at aa 13-35 and 698-717 218494007017 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494007018 PS00017 ATP/GTP-binding site motif A (P-loop). 218494007019 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 218494007020 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 218494007021 DHHA2 domain; Region: DHHA2; pfam02833 218494007022 HMMPfam hit to PF02833, DHHA2, score 2e-55 218494007023 HMMPfam hit to PF01368, Phosphoesterase, RecJ-like, score 7.5e-16 218494007024 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 218494007025 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 218494007026 active site 218494007027 Zn binding site [ion binding]; other site 218494007028 HMMPfam hit to PF01432, Peptidase M3A and M3B, thimet/oligopeptidase F, score 1.4e-11 218494007029 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 218494007030 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218494007031 FeS/SAM binding site; other site 218494007032 HMMPfam hit to PF04055, Radical SAM, score 2.5e-32 218494007033 PS01087 Radical activating enzymes signature. 218494007034 PS00190 Cytochrome c family heme-binding site signature. 218494007035 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 218494007036 Domain of unknown function DUF21; Region: DUF21; pfam01595 218494007037 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 218494007038 Transporter associated domain; Region: CorC_HlyC; cl08393 218494007039 HMMPfam hit to PF03471, Transporter-associated region, score 7.8e-20 218494007040 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 2e-26 218494007041 HMMPfam hit to PF01595, Protein of unknown function DUF21, score 1.2e-72 218494007042 4 probable transmembrane helices predicted for SSU1481 by TMHMM2.0 at aa 15-37, 63-85, 105-124 and 137-159 218494007043 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 218494007044 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494007045 Walker A/P-loop; other site 218494007046 ATP binding site [chemical binding]; other site 218494007047 Q-loop/lid; other site 218494007048 ABC transporter signature motif; other site 218494007049 Walker B; other site 218494007050 D-loop; other site 218494007051 H-loop/switch region; other site 218494007052 HMMPfam hit to PF00005, ABC transporter related, score 9.1e-47 218494007053 PS00017 ATP/GTP-binding site motif A (P-loop). 218494007054 PS00211 ABC transporters family signature. 218494007055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 218494007056 HMMPfam hit to PF06962, rRNA methylase, score 1.3e-82 218494007057 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 218494007058 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 218494007059 5 probable transmembrane helices predicted for SSU1484 by TMHMM2.0 at aa 4-21, 69-91, 117-146, 159-181 and 196-213 218494007060 HMMPfam hit to PF06750, Peptidase A24A, N-terminal, score 1.4e-33 218494007061 HMMPfam hit to PF01478, Peptidase A24A, prepilin type IV, score 4.5e-14 218494007062 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 218494007063 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 218494007064 active site 218494007065 HMMPfam hit to PF04095, Nicotinate phosphoribosyltransferase-like, score 8.4e-09 218494007066 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 218494007067 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 218494007068 homodimer interface [polypeptide binding]; other site 218494007069 NAD binding pocket [chemical binding]; other site 218494007070 ATP binding pocket [chemical binding]; other site 218494007071 Mg binding site [ion binding]; other site 218494007072 active-site loop [active] 218494007073 HMMPfam hit to PF02540, NAD+ synthase, score 1.5e-101 218494007074 VanZ like family; Region: VanZ; cl01971 218494007075 HMMPfam hit to PF04892, VanZ like protein, score 4.9e-11 218494007076 4 probable transmembrane helices predicted for SSU1487 by TMHMM2.0 at aa 21-40, 82-104, 113-132 and 147-164 218494007077 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 218494007078 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218494007079 FeS/SAM binding site; other site 218494007080 HMMPfam hit to PF04055, Radical SAM, score 2.9e-17 218494007081 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 218494007082 HMMPfam hit to PF06265, Protein of unknown function DUF1027, score 6.3e-51 218494007083 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 218494007084 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 218494007085 protein binding site [polypeptide binding]; other site 218494007086 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 218494007087 1 probable transmembrane helix predicted for SSU1490 by TMHMM2.0 at aa 7-26 218494007088 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 218494007089 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 218494007090 active site 218494007091 (T/H)XGH motif; other site 218494007092 HMMPfam hit to PF01467, Cytidylyltransferase, score 1.6e-22 218494007093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218494007094 S-adenosylmethionine binding site [chemical binding]; other site 218494007095 HMMPfam hit to PF03602, hypothetical protein CHP00095, score 1e-83 218494007096 PS00092 N-6 Adenine-specific DNA methylases signature. 218494007097 1 probable transmembrane helix predicted for SSU1493 by TMHMM2.0 at aa 10-32 218494007098 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 218494007099 active site residue [active] 218494007100 HMMPfam hit to PF00581, Rhodanese-like, score 4.8e-07 218494007101 PS00038 Myc-type, 'helix-loop-helix' dimerization domain signature. 218494007102 1 probable transmembrane helix predicted for SSU1494 by TMHMM2.0 at aa 4-26 218494007103 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 218494007104 HMMPfam hit to PF06014, Protein of unknown function DUF910, bacterial, score 2.1e-34 218494007105 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 218494007106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218494007107 active site 218494007108 phosphorylation site [posttranslational modification] 218494007109 intermolecular recognition site; other site 218494007110 dimerization interface [polypeptide binding]; other site 218494007111 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 218494007112 DNA binding residues [nucleotide binding] 218494007113 dimerization interface [polypeptide binding]; other site 218494007114 HMMPfam hit to PF00196, Bacterial regulatory protein, LuxR, score 3.3e-19 218494007115 PS00622 Bacterial regulatory proteins, luxR family signature. 218494007116 Predicted helix-turn-helix motif with score 1631.000, SD 4.74 at aa 154-175, sequence LSNKEIACQLHLSDGTVRNYMT 218494007117 HMMPfam hit to PF00072, Response regulator receiver, score 9.9e-27 218494007118 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 218494007119 Histidine kinase; Region: HisKA_3; pfam07730 218494007120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 218494007121 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 9.7e-05 218494007122 HMMPfam hit to PF07730, Histidine kinase, dimerisation and phosphoacceptor region, score 7e-22 218494007123 4 probable transmembrane helices predicted for SSU1497 by TMHMM2.0 at aa 20-42, 49-71, 91-113 and 120-139 218494007124 ABC-2 type transporter; Region: ABC2_membrane; cl11417 218494007125 6 probable transmembrane helices predicted for SSU1498 by TMHMM2.0 at aa 12-34, 47-69, 103-121, 131-153, 160-182 and 214-236 218494007126 HMMPfam hit to PF01061, ABC-2 type transporter, score 0.0011 218494007127 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 218494007128 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 218494007129 Walker A/P-loop; other site 218494007130 ATP binding site [chemical binding]; other site 218494007131 Q-loop/lid; other site 218494007132 ABC transporter signature motif; other site 218494007133 Walker B; other site 218494007134 D-loop; other site 218494007135 H-loop/switch region; other site 218494007136 HMMPfam hit to PF00005, ABC transporter related, score 6.6e-49 218494007137 PS00211 ABC transporters family signature. 218494007138 PS00017 ATP/GTP-binding site motif A (P-loop). 218494007139 Ferritin-like domain; Region: Ferritin; pfam00210 218494007140 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 218494007141 dimerization interface [polypeptide binding]; other site 218494007142 DPS ferroxidase diiron center [ion binding]; other site 218494007143 ion pore; other site 218494007144 HMMPfam hit to PF00210, Ferritin and Dps, score 8.2e-42 218494007145 CsbD-like; Region: CsbD; cl01272 218494007146 HMMPfam hit to PF05532, CsbD-like, score 3.8e-17 218494007147 Low molecular weight phosphatase family; Region: LMWPc; cd00115 218494007148 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 218494007149 active site 218494007150 HMMPfam hit to PF01451, Protein-tyrosine phosphatase, low molecular weight, score 7.5e-33 218494007151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 218494007152 MORN repeat; Region: MORN; cl14787 218494007153 1 probable transmembrane helix predicted for SSU1503 by TMHMM2.0 at aa 23-45 218494007154 HMMPfam hit to PF02493, MORN motif, score 5e-05 218494007155 HMMPfam hit to PF02493, MORN motif, score 8.5e-08 218494007156 HMMPfam hit to PF02493, MORN motif, score 0.01 218494007157 OpgC protein; Region: OpgC_C; cl00792 218494007158 Acyltransferase family; Region: Acyl_transf_3; pfam01757 218494007159 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 218494007160 active site 218494007161 catalytic triad [active] 218494007162 oxyanion hole [active] 218494007163 HMMPfam hit to PF01757, Acyltransferase 3, score 4e-31 218494007164 11 probable transmembrane helices predicted for SSU1504 by TMHMM2.0 at aa 7-24, 28-50, 69-91, 130-152, 165-187, 202-224, 237-259, 263-285, 297-319, 324-346 and 370-392 218494007165 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 218494007166 active site 218494007167 HMMPfam hit to PF01569, Phosphatidic acid phosphatase type 2-like, score 3.7e-27 218494007168 6 probable transmembrane helices predicted for SSU1505 by TMHMM2.0 at aa 13-35, 58-80, 87-109, 124-146, 153-175 and 185-203 218494007169 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 218494007170 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 218494007171 4 probable transmembrane helices predicted for SSU1506 by TMHMM2.0 at aa 7-29, 76-98, 111-133 and 153-175 218494007172 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 218494007173 HMMPfam hit to PF00588, tRNA/rRNA methyltransferase, SpoU, score 4.9e-42 218494007174 Domain of unknown function DUF37; Region: DUF37; cl00506 218494007175 HMMPfam hit to PF01809, Protein of unknown function DUF37, score 7.1e-37 218494007176 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 218494007177 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218494007178 RNA binding surface [nucleotide binding]; other site 218494007179 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 218494007180 active site 218494007181 HMMPfam hit to PF00849, Pseudouridine synthase, score 5.3e-24 218494007182 PS01149 Rsu family of pseudouridine synthase signature. 218494007183 HMMPfam hit to PF01479, RNA-binding S4, score 2.7e-15 218494007184 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 218494007185 HMMPfam hit to PF04079, Prokaryotic chromosome segregation and condensation protein ScpB, score 7.4e-71 218494007186 Predicted helix-turn-helix motif with score 1465.000, SD 4.18 at aa 19-40, sequence LTLRNLAEMLEMQPTAVSQQLE 218494007187 ScpA/B protein; Region: ScpA_ScpB; cl00598 218494007188 HMMPfam hit to PF02616, Prokaryotic chromosome segregation and condensation protein ScpA, score 1.2e-23 218494007189 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 218494007190 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 218494007191 DNA binding site [nucleotide binding] 218494007192 Int/Topo IB signature motif; other site 218494007193 active site 218494007194 catalytic residues [active] 218494007195 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 218494007196 FOG: CBS domain [General function prediction only]; Region: COG0517 218494007197 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 9.3e-16 218494007198 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 218494007199 active site 218494007200 metal binding site [ion binding]; metal-binding site 218494007201 homotetramer interface [polypeptide binding]; other site 218494007202 HMMPfam hit to PF00149, Metallophosphoesterase, score 3.6e-07 218494007203 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 218494007204 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 218494007205 active site 218494007206 dimerization interface [polypeptide binding]; other site 218494007207 HMMPfam hit to PF01725, Ham1-like protein, score 3e-72 218494007208 PS00017 ATP/GTP-binding site motif A (P-loop). 218494007209 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 218494007210 HMMPfam hit to PF01177, Asp/Glu/hydantoin racemase, score 8.8e-105 218494007211 PS00924 Aspartate and glutamate racemases signature 2. 218494007212 Uncharacterised protein family (UPF0154); Region: UPF0154; cl01536 218494007213 HMMPfam hit to PF03672, Protein of unknown function UPF0154, score 3e-22 218494007214 1 probable transmembrane helix predicted for SSU1518 by TMHMM2.0 at aa 5-24 218494007215 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 218494007216 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 218494007217 active site 218494007218 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 218494007219 substrate binding site [chemical binding]; other site 218494007220 catalytic residues [active] 218494007221 dimer interface [polypeptide binding]; other site 218494007222 HMMPfam hit to PF00278, Orn/DAP/Arg decarboxylase 2, score 2.6e-29 218494007223 HMMPfam hit to PF02784, Orn/DAP/Arg decarboxylase 2, score 7.9e-21 218494007224 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 218494007225 trimer interface [polypeptide binding]; other site 218494007226 active site 218494007227 G bulge; other site 218494007228 HMMPfam hit to PF03051, Peptidase C1B, bleomycin hydrolase, score 4.6e-292 218494007229 PS00139 Eukaryotic thiol (cysteine) proteases cysteine active site. 218494007230 PS00639 Eukaryotic thiol (cysteine) proteases histidine active site. 218494007231 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 218494007232 HMMPfam hit to PF01027, Protein of unknown function UPF0005, score 3.1e-11 218494007233 7 probable transmembrane helices predicted for SSU1521 by TMHMM2.0 at aa 23-45, 50-72, 85-107, 112-131, 144-161, 165-184 and 204-226 218494007234 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 218494007235 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 218494007236 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 218494007237 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 218494007238 HMMPfam hit to PF00588, tRNA/rRNA methyltransferase, SpoU, score 8.3e-52 218494007239 HMMPfam hit to PF08032, RNA 2-O ribose methyltransferase, substrate binding, score 1.5e-14 218494007240 Acylphosphatase; Region: Acylphosphatase; cl00551 218494007241 HMMPfam hit to PF00708, Acylphosphatase, score 1.1e-05 218494007242 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 218494007243 5 probable transmembrane helices predicted for SSU1525 by TMHMM2.0 at aa 7-24, 57-79, 130-152, 167-189 and 210-232 218494007244 HMMPfam hit to PF02096, 60 kDa inner membrane insertion protein, score 1.2e-30 218494007245 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 218494007246 domain; Region: GreA_GreB_N; pfam03449 218494007247 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 218494007248 HMMPfam hit to PF01272, Transcription elongation factor, GreA/GreB region, prokaryotic, score 4.6e-16 218494007249 PS00830 Prokaryotic transcription elongation factors signature 2. 218494007250 HMMPfam hit to PF03449, Transcription elongation factor, GreA/GreB region, prokaryotic, score 7.2e-25 218494007251 YceG-like family; Region: YceG; pfam02618 218494007252 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 218494007253 dimerization interface [polypeptide binding]; other site 218494007254 HMMPfam hit to PF02618, Aminodeoxychorismate lyase, score 1.5e-128 218494007255 1 probable transmembrane helix predicted for SSU1527 by TMHMM2.0 at aa 236-258 218494007256 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218494007257 Coenzyme A binding pocket [chemical binding]; other site 218494007258 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 8.6e-06 218494007259 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 218494007260 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 218494007261 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 218494007262 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 218494007263 HMMPfam hit to PF02875, Mur ligase, C-terminal, score 2.5e-16 218494007264 HMMPfam hit to PF08245, Mur ligase, central, score 9.7e-26 218494007265 HMMPfam hit to PF01225, Mur ligase, N-terminal, score 6.8e-35 218494007266 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 218494007267 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 218494007268 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218494007269 ATP binding site [chemical binding]; other site 218494007270 putative Mg++ binding site [ion binding]; other site 218494007271 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218494007272 nucleotide binding region [chemical binding]; other site 218494007273 ATP-binding site [chemical binding]; other site 218494007274 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 4.3e-26 218494007275 HMMPfam hit to PF00176, SNF2-related, score 2.6e-12 218494007276 HMMPfam hit to PF00176, SNF2-related, score 1.4e-47 218494007277 HMMPfam hit to PF08455, Helicase, SWF/SNF/SWI type, bacterial, score 8.1e-85 218494007278 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494007279 HMMPfam hit to PF04434, Zinc finger, SWIM-type, score 0.00029 218494007280 2 probable transmembrane helices predicted for SSU1532 by TMHMM2.0 at aa 31-53 and 60-82 218494007281 3 probable transmembrane helices predicted for SSU1533 by TMHMM2.0 at aa 4-23, 36-58 and 73-95 218494007282 GTP-binding protein Der; Reviewed; Region: PRK00093 218494007283 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA1; cd01894 218494007284 G1 box; other site 218494007285 GTP/Mg2+ binding site [chemical binding]; other site 218494007286 Switch I region; other site 218494007287 G2 box; other site 218494007288 Switch II region; other site 218494007289 G3 box; other site 218494007290 G4 box; other site 218494007291 G5 box; other site 218494007292 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA2; cd01895 218494007293 G1 box; other site 218494007294 GTP/Mg2+ binding site [chemical binding]; other site 218494007295 Switch I region; other site 218494007296 G2 box; other site 218494007297 G3 box; other site 218494007298 Switch II region; other site 218494007299 G4 box; other site 218494007300 G5 box; other site 218494007301 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 9.6e-44 218494007302 PS00017 ATP/GTP-binding site motif A (P-loop). 218494007303 HMMPfam hit to PF01926, GTP-binding protein, HSR1-related, score 3.1e-46 218494007304 PS00017 ATP/GTP-binding site motif A (P-loop). 218494007305 CDS contains a frameshift after codon 47. Frameshift occurs at a poly A heptamer. Similar to Vibrio harveyi frp nadph-flavin oxidoreductase (ec 1.6.99.-) (flavin reductase p) (nadph fmn oxidoreductase). UniProt:Q56691 (EMBL:VH08996) (240 aa) fasta scores: E()=1.1e-22, 37.607% id in 234 aa 218494007306 HMMPfam hit to PF00881, Nitroreductase, score 2.8e-26 218494007307 primosomal protein DnaI; Reviewed; Region: PRK08939 218494007308 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 218494007309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218494007310 Walker A motif; other site 218494007311 ATP binding site [chemical binding]; other site 218494007312 Walker B motif; other site 218494007313 PS00017 ATP/GTP-binding site motif A (P-loop). 218494007314 HMMPfam hit to PF07319, Primosomal DnaI, N-terminal, score 3e-42 218494007315 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 218494007316 HMMPfam hit to PF07261, Replication initiation and membrane attachment, score 7.6e-05 218494007317 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 218494007318 ATP cone domain; Region: ATP-cone; pfam03477 218494007319 HMMPfam hit to PF03477, ATP-cone, score 1.4e-35 218494007320 Domain of unknown function DUF20; Region: UPF0118; cl00465 218494007321 HMMPfam hit to PF01594, Protein of unknown function UPF0118, score 7.4e-37 218494007322 8 probable transmembrane helices predicted for SSU1539 by TMHMM2.0 at aa 9-31, 35-54, 75-97, 168-190, 234-256, 261-283, 290-312 and 332-354 218494007323 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 218494007324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218494007325 active site 218494007326 phosphorylation site [posttranslational modification] 218494007327 intermolecular recognition site; other site 218494007328 dimerization interface [polypeptide binding]; other site 218494007329 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 218494007330 DNA binding site [nucleotide binding] 218494007331 HMMPfam hit to PF00486, Transcriptional regulatory protein, C-terminal, score 8.2e-25 218494007332 HMMPfam hit to PF00072, Response regulator receiver, score 8.7e-08 218494007333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494007334 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 218494007335 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 218494007336 HMMPfam hit to PF00393, 6-phosphogluconate dehydrogenase, C-terminal, score 3.8e-246 218494007337 PS00461 6-phosphogluconate dehydrogenase signature. 218494007338 HMMPfam hit to PF03446, 6-phosphogluconate dehydrogenase, NAD-binding, score 6.6e-88 218494007339 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 218494007340 HMMPfam hit to PF02620, Protein of unknown function DUF177, score 1e-48 218494007341 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 218494007342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494007343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494007344 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 1.9e-42 218494007345 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 4.3e-29 218494007346 PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. 218494007347 2 probable transmembrane helices predicted for SSU1544 by TMHMM2.0 at aa 10-29 and 50-72 218494007348 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 218494007349 DEAD-like helicases superfamily; Region: DEXDc; smart00487 218494007350 ATP binding site [chemical binding]; other site 218494007351 Mg++ binding site [ion binding]; other site 218494007352 motif III; other site 218494007353 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218494007354 nucleotide binding region [chemical binding]; other site 218494007355 ATP-binding site [chemical binding]; other site 218494007356 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 7.5e-29 218494007357 HMMPfam hit to PF00270, DNA/RNA helicase, DEAD/DEAH box type, N-terminal, score 1.1e-59 218494007358 3 probable transmembrane helices predicted for SSU1546 by TMHMM2.0 at aa 78-100, 135-157 and 204-226 218494007359 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 218494007360 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 218494007361 Mg++ binding site [ion binding]; other site 218494007362 putative catalytic motif [active] 218494007363 putative substrate binding site [chemical binding]; other site 218494007364 10 probable transmembrane helices predicted for SSU1547 by TMHMM2.0 at aa 4-26, 47-69, 73-95, 116-135, 140-162, 175-192, 197-216, 223-245, 249-271 and 313-331 218494007365 HMMPfam hit to PF00953, Glycosyl transferase, family 4, score 2.5e-67 218494007366 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 218494007367 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 218494007368 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 218494007369 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 218494007370 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 218494007371 HMMPfam hit to PF03793, PASTA, score 1.6e-06 218494007372 HMMPfam hit to PF03793, PASTA, score 7e-07 218494007373 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 6.9e-73 218494007374 HMMPfam hit to PF03717, Penicillin-binding protein, dimerisation domain, score 1.2e-37 218494007375 1 probable transmembrane helix predicted for SSU1548 by TMHMM2.0 at aa 29-51 218494007376 Septum formation initiator; Region: DivIC; cl11433 218494007377 1 probable transmembrane helix predicted for SSU1549 by TMHMM2.0 at aa 27-49 218494007378 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 218494007379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 218494007380 HMMPfam hit to PF01795, Bacterial methyltransferase, score 7.1e-194 218494007381 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218494007382 non-specific DNA binding site [nucleotide binding]; other site 218494007383 salt bridge; other site 218494007384 sequence-specific DNA binding site [nucleotide binding]; other site 218494007385 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 2.2e-18 218494007386 Predicted helix-turn-helix motif with score 1966.000, SD 5.88 at aa 13-34, sequence ISQLDLAKAIGVSRQTINMIEN 218494007387 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 218494007388 4 probable transmembrane helices predicted for SSU1552 by TMHMM2.0 at aa 34-56, 66-88, 109-131 and 146-165 218494007389 2 probable transmembrane helices predicted for SSU1553 by TMHMM2.0 at aa 7-26 and 41-63 218494007390 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 218494007391 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 218494007392 8 probable transmembrane helices predicted for SSU1554 by TMHMM2.0 at aa 32-54, 58-80, 113-132, 147-165, 218-240, 244-263, 293-315 and 330-349 218494007393 3 probable transmembrane helices predicted for SSU1555 by TMHMM2.0 at aa 13-31, 60-82 and 89-106 218494007394 3 probable transmembrane helices predicted for SSU1556 by TMHMM2.0 at aa 7-29, 72-89 and 96-113 218494007395 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 218494007396 trimer interface [polypeptide binding]; other site 218494007397 1 probable transmembrane helix predicted for SSU1557 by TMHMM2.0 at aa 12-34 218494007398 HMMPfam hit to PF07009, Protein of unknown function DUF1312, score 1.2e-24 218494007399 UbiA prenyltransferase family; Region: UbiA; cl00337 218494007400 HMMPfam hit to PF01040, UbiA prenyltransferase, score 0.00064 218494007401 7 probable transmembrane helices predicted for SSU1558 by TMHMM2.0 at aa 43-65, 93-115, 120-142, 146-168, 188-210, 253-275 and 295-317 218494007402 ApbE family; Region: ApbE; cl00643 218494007403 HMMPfam hit to PF02424, ApbE-like lipoprotein, score 2.7e-56 218494007404 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494007405 FMN-binding domain; Region: FMN_bind; cl01081 218494007406 PS00017 ATP/GTP-binding site motif A (P-loop). 218494007407 HMMPfam hit to PF04205, FMN-binding, score 1e-18 218494007408 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494007409 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 218494007410 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 218494007411 substrate binding pocket [chemical binding]; other site 218494007412 chain length determination region; other site 218494007413 substrate-Mg2+ binding site; other site 218494007414 catalytic residues [active] 218494007415 aspartate-rich region 1; other site 218494007416 active site lid residues [active] 218494007417 aspartate-rich region 2; other site 218494007418 HMMPfam hit to PF00348, Polyprenyl synthetase, score 6e-35 218494007419 PS00444 Polyprenyl synthetases signature 2. 218494007420 PS00723 Polyprenyl synthetases signature 1. 218494007421 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 218494007422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494007423 5 probable transmembrane helices predicted for SSU1562 by TMHMM2.0 at aa 5-22, 159-181, 372-394, 546-568 and 578-600 218494007424 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 4.9e-20 218494007425 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 2.8e-06 218494007426 PS00017 ATP/GTP-binding site motif A (P-loop). 218494007427 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 218494007428 5 probable transmembrane helices predicted for SSU1563 by TMHMM2.0 at aa 7-29, 33-55, 62-84, 104-126 and 139-161 218494007429 HMMPfam hit to PF07456, Heptaprenyl diphosphate synthase component I, score 4e-58 218494007430 1 probable transmembrane helix predicted for SSU1564 by TMHMM2.0 at aa 20-37 218494007431 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 218494007432 Cation transport protein; Region: TrkH; cl10514 218494007433 10 probable transmembrane helices predicted for SSU1565 by TMHMM2.0 at aa 13-35, 74-96, 125-147, 152-174, 190-212, 227-249, 293-315, 353-372, 379-399 and 409-431 218494007434 HMMPfam hit to PF02386, Cation transporter, score 8.1e-68 218494007435 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 218494007436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494007437 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 218494007438 HMMPfam hit to PF02254, TrkA-N, score 1.3e-35 218494007439 HMMPfam hit to PF02080, TrkA-C, score 0.00011 218494007440 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 218494007441 MatE; Region: MatE; cl10513 218494007442 MatE; Region: MatE; cl10513 218494007443 12 probable transmembrane helices predicted for SSU1567 by TMHMM2.0 at aa 7-29, 49-71, 91-113, 133-150, 163-185, 190-212, 238-260, 280-302, 315-337, 352-374, 387-409 and 419-436 218494007444 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 1.3e-30 218494007445 HMMPfam hit to PF01554, Multi antimicrobial extrusion protein MatE, score 1.7e-22 218494007446 3 probable transmembrane helices predicted for SSU1568 by TMHMM2.0 at aa 5-27, 69-86 and 93-115 218494007447 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 218494007448 HMMPfam hit to PF05979, Protein of unknown function DUF896, bacterial, score 3.8e-43 218494007449 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 218494007450 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 218494007451 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 218494007452 HMMPfam hit to PF05746, DALR anticodon binding, score 5.9e-05 218494007453 HMMPfam hit to PF02092, Glycyl-tRNA synthetase, class IIc, beta subunit, N-terminal, score 5.5e-221 218494007454 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 218494007455 dimer interface [polypeptide binding]; other site 218494007456 motif 1; other site 218494007457 active site 218494007458 motif 2; other site 218494007459 motif 3; other site 218494007460 HMMPfam hit to PF02091, Glycyl-tRNA synthetase, class IIc, alpha subunit, score 8.8e-204 218494007461 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218494007462 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 218494007463 B3/4 domain; Region: B3_4; cl11458 218494007464 HMMPfam hit to PF03483, B3/4, score 1.9e-27 218494007465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 218494007466 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.7e-12 218494007467 5 probable transmembrane helices predicted for SSU1574 by TMHMM2.0 at aa 32-54, 75-97, 133-152, 164-186 and 201-223 218494007468 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 218494007469 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 218494007470 Walker A/P-loop; other site 218494007471 ATP binding site [chemical binding]; other site 218494007472 Q-loop/lid; other site 218494007473 ABC transporter signature motif; other site 218494007474 Walker B; other site 218494007475 D-loop; other site 218494007476 H-loop/switch region; other site 218494007477 NIL domain; Region: NIL; cl09633 218494007478 HMMPfam hit to PF00005, ABC transporter related, score 4.8e-67 218494007479 PS00211 ABC transporters family signature. 218494007480 PS00017 ATP/GTP-binding site motif A (P-loop). 218494007481 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 218494007482 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 218494007483 metal binding site [ion binding]; metal-binding site 218494007484 dimer interface [polypeptide binding]; other site 218494007485 HMMPfam hit to PF01546, Peptidase M20, score 4.7e-30 218494007486 HMMPfam hit to PF07687, Peptidase M20, dimerisation, score 1.9e-16 218494007487 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 218494007488 HMMPfam hit to PF03180, NLPA lipoprotein, score 1.4e-117 218494007489 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494007490 Peptidase C26; Region: Peptidase_C26; pfam07722 218494007491 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 218494007492 catalytic triad [active] 218494007493 HMMPfam hit to PF07722, Peptidase C26, score 5.5e-78 218494007494 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 218494007495 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 218494007496 THF binding site; other site 218494007497 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 218494007498 substrate binding site [chemical binding]; other site 218494007499 THF binding site; other site 218494007500 zinc-binding site [ion binding]; other site 218494007501 HMMPfam hit to PF08267, Cobalamin (vitamin B12)-independent methionine synthase MetE, N-terminal, score 2.3e-164 218494007502 HMMPfam hit to PF01717, Methionine synthase, vitamin-B12 independent, score 9.6e-181 218494007503 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 218494007504 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 218494007505 FAD binding site [chemical binding]; other site 218494007506 HMMPfam hit to PF02219, Methylenetetrahydrofolate reductase, score 3.3e-59 218494007507 Permease family; Region: Xan_ur_permease; cl00967 218494007508 12 probable transmembrane helices predicted for SSU1581 by TMHMM2.0 at aa 20-42, 49-71, 91-113, 125-147, 196-218, 225-247, 284-306, 335-357, 372-394, 401-418, 433-455 and 468-485 218494007509 HMMPfam hit to PF00860, Xanthine/uracil/vitamin C permease, score 3.1e-13 218494007510 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218494007511 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 218494007512 active site 218494007513 motif I; other site 218494007514 motif II; other site 218494007515 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 218494007516 PS01228 Hypothetical cof family signature 1. 218494007517 HMMPfam hit to PF08282, HAD superfamily hydrolase-like, type 3, score 6.3e-73 218494007518 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 218494007519 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 218494007520 active pocket/dimerization site; other site 218494007521 active site 218494007522 phosphorylation site [posttranslational modification] 218494007523 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 218494007524 active site 218494007525 phosphorylation site [posttranslational modification] 218494007526 HMMPfam hit to PF03610, Phosphotransferase system, fructose subfamily IIA component, score 1.7e-53 218494007527 HMMPfam hit to PF03830, Phosphotransferase system, sorbose subfamily IIB component, score 5e-86 218494007528 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 218494007529 HMMPfam hit to PF03609, Phosphotransferase system, sorbose-specific IIC subunit, score 3e-136 218494007530 7 probable transmembrane helices predicted for SSU1584 by TMHMM2.0 at aa 7-25, 35-57, 64-86, 96-118, 144-166, 181-203 and 210-243 218494007531 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 218494007532 HMMPfam hit to PF03613, Phosphotransferase system, mannose/fructose/sorbose family IID component, score 4.8e-198 218494007533 4 probable transmembrane helices predicted for SSU1585 by TMHMM2.0 at aa 125-147, 185-207, 260-277 and 284-302 218494007534 Domain of unknown function (DUF956); Region: DUF956; cl01917 218494007535 HMMPfam hit to PF06115, Protein of unknown function DUF956, score 7.1e-73 218494007536 seryl-tRNA synthetase; Provisional; Region: PRK05431 218494007537 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 218494007538 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 218494007539 dimer interface [polypeptide binding]; other site 218494007540 active site 218494007541 motif 1; other site 218494007542 motif 2; other site 218494007543 motif 3; other site 218494007544 HMMPfam hit to PF02403, Seryl-tRNA synthetase, class IIa, N-terminal, score 2.4e-44 218494007545 HMMPfam hit to PF00587, Aminoacyl-tRNA synthetase, class II (G, H, P and S), score 5.2e-75 218494007546 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 218494007547 HsdM N-terminal domain; Region: HsdM_N; pfam12161 218494007548 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 218494007549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 218494007550 HMMPfam hit to PF02384, N-6 DNA methylase, score 4.5e-165 218494007551 PS00092 N-6 Adenine-specific DNA methylases signature. 218494007552 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 218494007553 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 218494007554 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 218494007555 HMMPfam hit to PF01420, Restriction endonuclease, type I, S subunit, EcoBI, score 4.1e-07 218494007556 HMMPfam hit to PF01420, Restriction endonuclease, type I, S subunit, EcoBI, score 1.5e-07 218494007557 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 218494007558 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 218494007559 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 218494007560 ATP binding site [chemical binding]; other site 218494007561 putative Mg++ binding site [ion binding]; other site 218494007562 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 218494007563 HMMPfam hit to PF04851, Restriction endonuclease, type I, R subunit/Type III, Res subunit, score 1.2e-37 218494007564 HMMPfam hit to PF04313, Restriction endonuclease, type I, EcoRI, R subunit/Type III, Res subunit, N terminus, score 3.5e-07 218494007565 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 218494007566 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 218494007567 Phage integrase family; Region: Phage_integrase; pfam00589 218494007568 Int/Topo IB signature motif; other site 218494007569 HMMPfam hit to PF00589, Integrase, catalytic core, phage, score 4.5e-19 218494007570 Similar to Streptococcus agalactiae 515 protease UniProt:Q3DMK6 (221 aa) fasta scores: E()=2.9e-13, 32.683% id in 205 aa. CDS contains a frameshift after codon 81 218494007571 2 probable transmembrane helices predicted for SSU1593 by TMHMM2.0 at aa 62-84 and 110-129 218494007572 HMMPfam hit to PF02517, Abortive infection protein, score 1.1e-15 218494007573 2 probable transmembrane helices predicted for SSU1594 by TMHMM2.0 at aa 16-35 and 40-62 218494007574 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 218494007575 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 8.6e-12 218494007576 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 218494007577 HMMPfam hit to PF03255, Acetyl-CoA carboxylase, alpha subunit, score 1.3e-27 218494007578 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 218494007579 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 218494007580 HMMPfam hit to PF01039, Carboxyl transferase, score 6.7e-12 218494007581 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 218494007582 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 218494007583 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 218494007584 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 218494007585 HMMPfam hit to PF02785, Biotin carboxylase, C-terminal, score 9.9e-55 218494007586 HMMPfam hit to PF02786, Carbamoyl-phosphate synthase L chain, ATP-binding, score 3.3e-97 218494007587 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 218494007588 PS00866 Carbamoyl-phosphate synthase subdomain signature 1. 218494007589 HMMPfam hit to PF00289, Carbamoyl-phosphate synthetase large chain, N-terminal, score 5.1e-48 218494007590 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 218494007591 HMMPfam hit to PF07977, Beta-hydroxyacyl-(acyl-carrier-protein) dehydratase, FabA/FabZ, score 3.8e-66 218494007592 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 218494007593 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 218494007594 carboxyltransferase (CT) interaction site; other site 218494007595 biotinylation site [posttranslational modification]; other site 218494007596 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 8.8e-26 218494007597 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 218494007598 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 218494007599 dimer interface [polypeptide binding]; other site 218494007600 active site 218494007601 HMMPfam hit to PF02801, Beta-ketoacyl synthase, C-terminal, score 1e-44 218494007602 HMMPfam hit to PF00109, Beta-ketoacyl synthase, N-terminal, score 8.7e-66 218494007603 PS00606 Beta-ketoacyl synthases active site. 218494007604 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 218494007605 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 218494007606 NAD(P) binding site [chemical binding]; other site 218494007607 homotetramer interface [polypeptide binding]; other site 218494007608 homodimer interface [polypeptide binding]; other site 218494007609 active site 218494007610 HMMPfam hit to PF00106, Short-chain dehydrogenase/reductase SDR, score 7.1e-49 218494007611 PS00061 Short-chain dehydrogenases/reductases family signature. 218494007612 Acyl transferase domain; Region: Acyl_transf_1; cl08282 218494007613 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 218494007614 HMMPfam hit to PF00698, Acyl transferase, score 4.1e-20 218494007615 putative enoyl-(acyl-carrier-protein) reductase II; Region: enACPred_II; TIGR03151 218494007616 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 218494007617 FMN binding site [chemical binding]; other site 218494007618 substrate binding site [chemical binding]; other site 218494007619 putative catalytic residue [active] 218494007620 HMMPfam hit to PF03060, 2-nitropropane dioxygenase, NPD, score 1.9e-103 218494007621 PS00912 Dihydroorotate dehydrogenase signature 2. 218494007622 Phosphopantetheine attachment site; Region: PP-binding; cl09936 218494007623 HMMPfam hit to PF00550, Phosphopantetheine-binding, score 4.8e-14 218494007624 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 218494007625 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 218494007626 dimer interface [polypeptide binding]; other site 218494007627 active site 218494007628 CoA binding pocket [chemical binding]; other site 218494007629 HMMPfam hit to PF08541, 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C-terminal, score 1.3e-42 218494007630 HMMPfam hit to PF08545, 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III, score 3.4e-41 218494007631 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494007632 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 3.5e-16 218494007633 PS00215 Mitochondrial energy transfer proteins signature. 218494007634 enoyl-CoA hydratase; Provisional; Region: PRK07260 218494007635 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 218494007636 substrate binding site [chemical binding]; other site 218494007637 oxyanion hole (OAH) forming residues; other site 218494007638 trimer interface [polypeptide binding]; other site 218494007639 HMMPfam hit to PF00378, Crotonase, core, score 4e-24 218494007640 2 probable transmembrane helices predicted for SSU1609 by TMHMM2.0 at aa 102-124 and 134-156 218494007641 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 218494007642 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 218494007643 motif II; other site 218494007644 HMMPfam hit to PF00702, Haloacid dehalogenase-like hydrolase, score 1.7e-24 218494007645 aspartate kinase; Reviewed; Region: PRK09034 218494007646 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 218494007647 putative catalytic residues [active] 218494007648 putative nucleotide binding site [chemical binding]; other site 218494007649 putative aspartate binding site [chemical binding]; other site 218494007650 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 218494007651 allosteric regulatory residue; other site 218494007652 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 218494007653 HMMPfam hit to PF00696, Aspartate/glutamate/uridylate kinase, score 1e-38 218494007654 PS00324 Aspartokinase signature. 218494007655 HMMPfam hit to PF01842, Amino acid-binding ACT, score 2.1 218494007656 HMMPfam hit to PF01842, Amino acid-binding ACT, score 1.3e-05 218494007657 alanine racemase; Reviewed; Region: alr; PRK00053 218494007658 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 218494007659 active site 218494007660 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 218494007661 dimer interface [polypeptide binding]; other site 218494007662 substrate binding site [chemical binding]; other site 218494007663 catalytic residues [active] 218494007664 HMMPfam hit to PF00842, Alanine racemase, C-terminal, score 7.1e-67 218494007665 HMMPfam hit to PF01168, Alanine racemase, N-terminal, score 1.9e-85 218494007666 PS00395 Alanine racemase pyridoxal-phosphate attachment site. 218494007667 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 218494007668 HMMPfam hit to PF01648, 4'-phosphopantetheinyl transferase, score 3.6e-15 218494007669 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 218494007670 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 218494007671 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 218494007672 nucleotide binding region [chemical binding]; other site 218494007673 ATP-binding site [chemical binding]; other site 218494007674 SEC-C motif; Region: SEC-C; pfam02810 218494007675 HMMPfam hit to PF02810, SEC-C motif, score 1.2e-06 218494007676 HMMPfam hit to PF07516, SecA Wing and Scaffold, score 9.8e-62 218494007677 HMMPfam hit to PF00271, DNA/RNA helicase, C-terminal, score 0.0051 218494007678 PS01312 Protein secA signatures. 218494007679 HMMPfam hit to PF07517, SecA DEAD-like, score 1.7e-199 218494007680 PS00017 ATP/GTP-binding site motif A (P-loop). 218494007681 HMMPfam hit to PF01043, SecA preprotein cross-linking region, score 1.3e-61 218494007682 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 218494007683 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 218494007684 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 218494007685 HMMPfam hit to PF00480, ROK, score 4.4e-78 218494007686 PS01125 ROK family signature. 218494007687 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 218494007688 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218494007689 active site turn [active] 218494007690 phosphorylation site [posttranslational modification] 218494007691 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 218494007692 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 218494007693 HPr interaction site; other site 218494007694 glycerol kinase (GK) interaction site [polypeptide binding]; other site 218494007695 active site 218494007696 phosphorylation site [posttranslational modification] 218494007697 HMMPfam hit to PF00358, Phosphotransferase system, sugar-specific permease EIIA 1 domain, score 6.2e-75 218494007698 PS00371 PTS EIIA domains phosphorylation site signature 1. 218494007699 10 probable transmembrane helices predicted for SSU1618 by TMHMM2.0 at aa 111-133, 148-170, 175-197, 207-229, 250-272, 282-304, 325-347, 357-379, 384-406 and 426-448 218494007700 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 6.9e-45 218494007701 PS00044 Bacterial regulatory proteins, lysR family signature. 218494007702 HMMPfam hit to PF00367, Phosphotransferase system, EIIB, score 2.2e-17 218494007703 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 218494007704 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 218494007705 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 218494007706 substrate binding [chemical binding]; other site 218494007707 active site 218494007708 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 218494007709 HMMPfam hit to PF00251, Glycosyl hydrolases family 32, N-terminal, score 1.7e-134 218494007710 HMMPfam hit to PF08244, Glycosyl hydrolase family 32, C-terminal, score 7.4e-13 218494007711 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218494007712 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218494007713 DNA binding site [nucleotide binding] 218494007714 domain linker motif; other site 218494007715 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 218494007716 dimerization interface [polypeptide binding]; other site 218494007717 ligand binding site [chemical binding]; other site 218494007718 sodium binding site [ion binding]; other site 218494007719 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 4e-12 218494007720 Predicted helix-turn-helix motif with score 2082.000, SD 6.28 at aa 3-24, sequence AKLTDVAQLAGVSPTTVSRVIN 218494007721 PS00356 Bacterial regulatory proteins, lacI family signature. 218494007722 PS00017 ATP/GTP-binding site motif A (P-loop). 218494007723 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 4.4e-08 218494007724 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 218494007725 putative RNA binding site [nucleotide binding]; other site 218494007726 HMMPfam hit to PF01029, NusB/RsmB/TIM44, score 3.1e-34 218494007727 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218494007728 Protein of unknown function (DUF322); Region: DUF322; cl00574 218494007729 HMMPfam hit to PF03780, Protein of unknown function DUF322, score 2e-38 218494007730 elongation factor P; Validated; Region: PRK00529 218494007731 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 218494007732 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 218494007733 RNA binding site [nucleotide binding]; other site 218494007734 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 218494007735 RNA binding site [nucleotide binding]; other site 218494007736 HMMPfam hit to PF09285, Elongation factor P, C-terminal, score 9.9e-31 218494007737 PS01275 Elongation factor P signature. 218494007738 HMMPfam hit to PF01132, Translation elongation factor P/YeiP, central, score 6.6e-12 218494007739 HMMPfam hit to PF08207, Translation elongation factor, KOW-like, score 7.8e-18 218494007740 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 218494007741 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 218494007742 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 218494007743 active site 218494007744 HMMPfam hit to PF00557, Peptidase M24, catalytic core, score 8.4e-65 218494007745 PS00491 Aminopeptidase P and proline dipeptidase signature. 218494007746 HMMPfam hit to PF01321, Creatinase, score 1.6e-25 218494007747 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 218494007748 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 218494007749 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 218494007750 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 218494007751 HMMPfam hit to PF00005, ABC transporter related, score 2.8e-30 218494007752 PS00211 ABC transporters family signature. 218494007753 PS00190 Cytochrome c family heme-binding site signature. 218494007754 PS00017 ATP/GTP-binding site motif A (P-loop). 218494007755 PS00211 ABC transporters family signature. 218494007756 PS00190 Cytochrome c family heme-binding site signature. 218494007757 PS00017 ATP/GTP-binding site motif A (P-loop). 218494007758 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 218494007759 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 218494007760 HMMPfam hit to PF01544, Mg2+ transporter protein, CorA-like, score 1.7e-12 218494007761 2 probable transmembrane helices predicted for SSU1626 by TMHMM2.0 at aa 254-273 and 288-310 218494007762 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 218494007763 HMMPfam hit to PF06570, Uncharacterised conserved protein UCP033111, membrane associated, score 8.5e-100 218494007764 4 probable transmembrane helices predicted for SSU1627 by TMHMM2.0 at aa 86-108, 118-140, 153-175 and 185-204 218494007765 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 218494007766 HMMPfam hit to PF01084, Ribosomal protein S18, score 1.3e-34 218494007767 PS00057 Ribosomal protein S18 signature. 218494007768 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 218494007769 dimer interface [polypeptide binding]; other site 218494007770 ssDNA binding site [nucleotide binding]; other site 218494007771 tetramer (dimer of dimers) interface [polypeptide binding]; other site 218494007772 HMMPfam hit to PF00436, Primosome PriB/single-strand DNA-binding, score 4e-33 218494007773 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 218494007774 HMMPfam hit to PF01250, Ribosomal protein S6, score 2.3e-28 218494007775 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 218494007776 Integrase core domain; Region: rve; cl01316 218494007777 Predicted helix-turn-helix motif with score 1377.000, SD 3.88 at aa 22-43, sequence KPFSAIAAKLGKDPSTISKEVR 218494007778 HMMPfam hit to PF00665, Integrase, catalytic core, score 9.1e-14 218494007779 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 218494007780 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 218494007781 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 218494007782 HMMPfam hit to PF03099, Biotin/lipoate A/B protein ligase, score 7.7e-20 218494007783 6 probable transmembrane helices predicted for SSU1633 by TMHMM2.0 at aa 15-37, 64-86, 106-126, 133-155, 165-187 and 218-240 218494007784 Predicted helix-turn-helix motif with score 1038.000, SD 2.72 at aa 192-213, sequence LWQAELAKQSNPRFPRLSALLQ 218494007785 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 218494007786 E3 interaction surface; other site 218494007787 lipoyl attachment site [posttranslational modification]; other site 218494007788 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 218494007789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494007790 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 218494007791 HMMPfam hit to PF02852, Pyridine nucleotide-disulphide oxidoreductase dimerisation region, score 2.5e-52 218494007792 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 2.7e-60 218494007793 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 4e-27 218494007794 PS00076 Pyridine nucleotide-disulphide oxidoreductases class-I active site. 218494007795 PS00430 TonB-dependent receptor proteins signature 1. 218494007796 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 3e-22 218494007797 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 218494007798 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 218494007799 E3 interaction surface; other site 218494007800 lipoyl attachment site [posttranslational modification]; other site 218494007801 e3 binding domain; Region: E3_binding; pfam02817 218494007802 e3 binding domain; Region: E3_binding; pfam02817 218494007803 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 218494007804 HMMPfam hit to PF00198, Catalytic domain of components of various dehydrogenase complexes, score 9.4e-119 218494007805 HMMPfam hit to PF02817, E3 binding, score 3.6e-13 218494007806 HMMPfam hit to PF02817, E3 binding, score 5.6e-16 218494007807 HMMPfam hit to PF00364, Biotin/lipoyl attachment, score 2.6e-22 218494007808 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 218494007809 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 218494007810 alpha subunit interface [polypeptide binding]; other site 218494007811 TPP binding site [chemical binding]; other site 218494007812 heterodimer interface [polypeptide binding]; other site 218494007813 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 218494007814 HMMPfam hit to PF02780, Transketolase, C-terminal, score 3e-55 218494007815 HMMPfam hit to PF02779, Transketolase, central region, score 3.7e-65 218494007816 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 218494007817 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 218494007818 tetramer interface [polypeptide binding]; other site 218494007819 TPP-binding site [chemical binding]; other site 218494007820 heterodimer interface [polypeptide binding]; other site 218494007821 phosphorylation loop region [posttranslational modification] 218494007822 HMMPfam hit to PF00676, Dehydrogenase, E1 component, score 9.8e-109 218494007823 UPF0126 domain; Region: UPF0126; pfam03458 218494007824 hypothetical protein; Provisional; Region: PRK10578 218494007825 UPF0126 domain; Region: UPF0126; pfam03458 218494007826 7 probable transmembrane helices predicted for SSU1638 by TMHMM2.0 at aa 32-51, 58-77, 92-110, 123-145, 150-172, 189-208 and 212-231 218494007827 HMMPfam hit to PF03458, Protein of unknown function UPF0126, score 4.6e-22 218494007828 HMMPfam hit to PF03458, Protein of unknown function UPF0126, score 1.2e-24 218494007829 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494007830 HMMPfam hit to PF02402, Colicin lysis protein, score 0.007 218494007831 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494007832 Ribosome-binding factor A; Region: RBFA; cl00542 218494007833 HMMPfam hit to PF02033, Ribosome-binding factor A, score 1.2e-30 218494007834 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 218494007835 translation initiation factor IF-2; Region: IF-2; TIGR00487 218494007836 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 218494007837 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases; Region: IF2_eIF5B; cd01887 218494007838 G1 box; other site 218494007839 putative GEF interaction site [polypeptide binding]; other site 218494007840 GTP/Mg2+ binding site [chemical binding]; other site 218494007841 Switch I region; other site 218494007842 G2 box; other site 218494007843 G3 box; other site 218494007844 Switch II region; other site 218494007845 G4 box; other site 218494007846 G5 box; other site 218494007847 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 218494007848 Translation-initiation factor 2; Region: IF-2; pfam11987 218494007849 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 218494007850 HMMPfam hit to PF03144, Translation elongation factor EFTu/EF1A, domain 2, score 1.5e-11 218494007851 HMMPfam hit to PF00009, Protein synthesis factor, GTP-binding, score 7.1e-55 218494007852 PS00017 ATP/GTP-binding site motif A (P-loop). 218494007853 HMMPfam hit to PF04760, Translation initiation factor IF-2, N-terminal, score 1.4e-21 218494007854 HMMPfam hit to PF04760, Translation initiation factor IF-2, N-terminal, score 6.1e-15 218494007855 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 218494007856 HMMPfam hit to PF01248, Ribosomal protein L7Ae/L30e/S12e/Gadd45, score 2.3e-17 218494007857 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 218494007858 putative RNA binding cleft [nucleotide binding]; other site 218494007859 HMMPfam hit to PF04296, Protein of unknown function DUF448, score 6.2e-38 218494007860 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 218494007861 NusA N-terminal domain; Region: NusA_N; pfam08529 218494007862 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 218494007863 RNA binding site [nucleotide binding]; other site 218494007864 homodimer interface [polypeptide binding]; other site 218494007865 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 218494007866 G-X-X-G motif; other site 218494007867 HMMPfam hit to PF00013, K Homology, type 1, score 0.015 218494007868 HMMPfam hit to PF00575, S1, RNA binding, score 4.2e-07 218494007869 HMMPfam hit to PF08529, Transcription factor NusA, N-terminal, score 4.4e-52 218494007870 ribosome maturation protein RimP; Reviewed; Region: PRK00092 218494007871 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 218494007872 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 218494007873 Sm1 motif; other site 218494007874 predicted subunit interaction site [polypeptide binding]; other site 218494007875 RNA binding pocket [nucleotide binding]; other site 218494007876 Sm2 motif; other site 218494007877 HMMPfam hit to PF02576, Protein of unknown function DUF150, score 1.8e-62 218494007878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218494007879 S-adenosylmethionine binding site [chemical binding]; other site 218494007880 HMMPfam hit to PF02390, methyltransferase, score 8.5e-62 218494007881 Phosphotransferase enzyme family; Region: APH; pfam01636 218494007882 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 218494007883 active site 218494007884 ATP binding site [chemical binding]; other site 218494007885 substrate binding site [chemical binding]; other site 218494007886 HMMPfam hit to PF01636, Aminoglycoside phosphotransferase, score 1.3e-21 218494007887 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 218494007888 HMMPfam hit to PF05975, Bacterial ABC transporter EcsB, score 1.3e-123 218494007889 8 probable transmembrane helices predicted for SSU1649 by TMHMM2.0 at aa 21-43, 53-75, 105-124, 129-148, 227-244, 248-270, 296-315 and 320-339 218494007890 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 218494007891 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 218494007892 Walker A/P-loop; other site 218494007893 ATP binding site [chemical binding]; other site 218494007894 Q-loop/lid; other site 218494007895 ABC transporter signature motif; other site 218494007896 Walker B; other site 218494007897 D-loop; other site 218494007898 H-loop/switch region; other site 218494007899 HMMPfam hit to PF00005, ABC transporter related, score 1.3e-45 218494007900 PS00211 ABC transporters family signature. 218494007901 PS00017 ATP/GTP-binding site motif A (P-loop). 218494007902 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 218494007903 HIT family signature motif; other site 218494007904 catalytic residue [active] 218494007905 HMMPfam hit to PF01230, Histidine triad (HIT) protein, score 7.4e-41 218494007906 PS00892 HIT family signature. 218494007907 endonuclease subunit; Provisional; Region: 46; PHA02562 218494007908 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 218494007909 HMMPfam hit to PF03816, Cell envelope-related transcriptional attenuator, score 1.3e-68 218494007910 PS00237 G-protein coupled receptors signature. 218494007911 1 probable transmembrane helix predicted for SSU1653 by TMHMM2.0 at aa 7-29 218494007912 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 218494007913 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218494007914 Coenzyme A binding pocket [chemical binding]; other site 218494007915 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 218494007916 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 8e-21 218494007917 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 218494007918 HMMPfam hit to PF02367, Protein of unknown function UPF0079, ATPase bacteria, score 3.4e-46 218494007919 PS00017 ATP/GTP-binding site motif A (P-loop). 218494007920 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 218494007921 DAK2 domain; Region: Dak2; cl03685 218494007922 HMMPfam hit to PF02734, Dak phosphatase, score 9e-78 218494007923 Protein of unknown function (DUF322); Region: DUF322; cl00574 218494007924 HMMPfam hit to PF03780, Protein of unknown function DUF322, score 1.2e-52 218494007925 CDS contains a frameshift after codon 242. Similar to Lactobacillus delbrueckii (subsp. lactis) isldl4 transposase. UniProt:Q937G2 (EMBL:LDE316615) (406 aa) fasta scores: E()=1.8e-62, 49.367% id in 395 aa 218494007926 HMMPfam hit to PF01548, Transposase, IS111A/IS1328/IS1533, score 0.00011 218494007927 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 1.2e-20 218494007928 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 218494007929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494007930 dimer interface [polypeptide binding]; other site 218494007931 conserved gate region; other site 218494007932 putative PBP binding loops; other site 218494007933 ABC-ATPase subunit interface; other site 218494007934 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.5e-36 218494007935 6 probable transmembrane helices predicted for SSU1660 by TMHMM2.0 at aa 31-53, 99-121, 128-150, 155-172, 208-230 and 266-288 218494007936 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 218494007937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494007938 dimer interface [polypeptide binding]; other site 218494007939 conserved gate region; other site 218494007940 putative PBP binding loops; other site 218494007941 ABC-ATPase subunit interface; other site 218494007942 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 6.4e-56 218494007943 6 probable transmembrane helices predicted for SSU1661 by TMHMM2.0 at aa 5-27, 98-120, 133-155, 182-204, 243-265 and 285-307 218494007944 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218494007945 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 218494007946 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 218494007947 Walker A/P-loop; other site 218494007948 ATP binding site [chemical binding]; other site 218494007949 Q-loop/lid; other site 218494007950 ABC transporter signature motif; other site 218494007951 Walker B; other site 218494007952 D-loop; other site 218494007953 H-loop/switch region; other site 218494007954 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218494007955 HMMPfam hit to PF08352, Oligopeptide/dipeptide ABC transporter, C-terminal, score 4.8e-06 218494007956 HMMPfam hit to PF00005, ABC transporter related, score 1e-58 218494007957 PS00211 ABC transporters family signature. 218494007958 PS00017 ATP/GTP-binding site motif A (P-loop). 218494007959 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 218494007960 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 218494007961 Walker A/P-loop; other site 218494007962 ATP binding site [chemical binding]; other site 218494007963 Q-loop/lid; other site 218494007964 ABC transporter signature motif; other site 218494007965 Walker B; other site 218494007966 D-loop; other site 218494007967 H-loop/switch region; other site 218494007968 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 218494007969 HMMPfam hit to PF08352, Oligopeptide/dipeptide ABC transporter, C-terminal, score 1.1e-19 218494007970 HMMPfam hit to PF00005, ABC transporter related, score 1.6e-63 218494007971 PS00211 ABC transporters family signature. 218494007972 PS00017 ATP/GTP-binding site motif A (P-loop). 218494007973 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 218494007974 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 218494007975 peptide binding site [polypeptide binding]; other site 218494007976 HMMPfam hit to PF00496, Bacterial extracellular solute-binding protein, family 5, score 8.9e-57 218494007977 PS00017 ATP/GTP-binding site motif A (P-loop). 218494007978 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494007979 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 218494007980 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 218494007981 HMMPfam hit to PF00768, Peptidase S11, D-alanyl-D-alanine carboxypeptidase A, score 2.1e-93 218494007982 HMMPfam hit to PF07943, Peptidase S11, D-Ala-D-Ala carboxypeptidase A, C-terminal, score 5.5e-15 218494007983 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 218494007984 FeS assembly protein SufB; Region: sufB; TIGR01980 218494007985 HMMPfam hit to PF01458, SUF system FeS cluster assembly, SufBD, score 1.7e-119 218494007986 Probable gene remnant. Similar to an internal region of Borrelia burgdorferi (Lyme disease spirochete) 30S ribosomal protein S15 RpsO UniProt:O51744 (EMBL:AE001179) (88 aa) fasta scores: E()=1.4, 33.333% id in 42 aa 218494007987 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 218494007988 trimerization site [polypeptide binding]; other site 218494007989 active site 218494007990 HMMPfam hit to PF01592, NIF system FeS cluster assembly, NifU, N-terminal, score 2.8e-23 218494007991 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 218494007992 Aminotransferase class-V; Region: Aminotran_5; pfam00266 218494007993 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 218494007994 catalytic residue [active] 218494007995 HMMPfam hit to PF00266, Aminotransferase, class V, score 4.9e-211 218494007996 PS00595 Aminotransferases class-V pyridoxal-phosphate attachment site. 218494007997 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 218494007998 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 218494007999 HMMPfam hit to PF01458, SUF system FeS cluster assembly, SufBD, score 8.1e-54 218494008000 FeS assembly ATPase SufC; Region: sufC; TIGR01978 218494008001 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 218494008002 Walker A/P-loop; other site 218494008003 ATP binding site [chemical binding]; other site 218494008004 Q-loop/lid; other site 218494008005 ABC transporter signature motif; other site 218494008006 Walker B; other site 218494008007 D-loop; other site 218494008008 H-loop/switch region; other site 218494008009 HMMPfam hit to PF00005, ABC transporter related, score 3.1e-31 218494008010 PS00211 ABC transporters family signature. 218494008011 PS00017 ATP/GTP-binding site motif A (P-loop). 218494008012 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 218494008013 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 218494008014 Mg++ binding site [ion binding]; other site 218494008015 putative catalytic motif [active] 218494008016 substrate binding site [chemical binding]; other site 218494008017 11 probable transmembrane helices predicted for SSU1672 by TMHMM2.0 at aa 4-26, 51-73, 83-102, 115-132, 147-169, 174-196, 200-217, 224-243, 253-275, 296-318 and 333-355 218494008018 HMMPfam hit to PF00953, Glycosyl transferase, family 4, score 7.4e-40 218494008019 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 218494008020 HMMPfam hit to PF05389, Negative regulator of genetic competence, score 2.3e-89 218494008021 Bacitracin resistance protein BacA; Region: BacA; cl00858 218494008022 6 probable transmembrane helices predicted for SSU1674 by TMHMM2.0 at aa 43-65, 86-104, 114-132, 192-214, 224-246 and 258-277 218494008023 HMMPfam hit to PF02673, Bacitracin resistance protein BacA, score 8.9e-120 218494008024 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 218494008025 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218494008026 substrate binding pocket [chemical binding]; other site 218494008027 membrane-bound complex binding site; other site 218494008028 hinge residues; other site 218494008029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494008030 dimer interface [polypeptide binding]; other site 218494008031 conserved gate region; other site 218494008032 putative PBP binding loops; other site 218494008033 ABC-ATPase subunit interface; other site 218494008034 5 probable transmembrane helices predicted for SSU1675 by TMHMM2.0 at aa 5-22, 298-320, 341-363, 378-400 and 473-495 218494008035 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 1.7e-37 218494008036 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 5e-25 218494008037 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218494008038 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 218494008039 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 218494008040 Walker A/P-loop; other site 218494008041 ATP binding site [chemical binding]; other site 218494008042 Q-loop/lid; other site 218494008043 ABC transporter signature motif; other site 218494008044 Walker B; other site 218494008045 D-loop; other site 218494008046 H-loop/switch region; other site 218494008047 HMMPfam hit to PF00005, ABC transporter related, score 2e-64 218494008048 PS00017 ATP/GTP-binding site motif A (P-loop). 218494008049 PS00211 ABC transporters family signature. 218494008050 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 218494008051 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 218494008052 HMMPfam hit to PF01145, Band 7 protein, score 1e-43 218494008053 1 probable transmembrane helix predicted for SSU1678 by TMHMM2.0 at aa 7-29 218494008054 threonine dehydratase; Validated; Region: PRK08639 218494008055 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 218494008056 tetramer interface [polypeptide binding]; other site 218494008057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 218494008058 catalytic residue [active] 218494008059 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 218494008060 putative Ile/Val binding site [chemical binding]; other site 218494008061 HMMPfam hit to PF00585, Threonine dehydratase, C-terminal, score 4.9e-39 218494008062 HMMPfam hit to PF00291, Pyridoxal phosphate-dependent enzyme, beta subunit, score 2e-89 218494008063 PS00017 ATP/GTP-binding site motif A (P-loop). 218494008064 PS00165 Serine/threonine dehydratases pyridoxal-phosphate attachment site. 218494008065 ketol-acid reductoisomerase; Provisional; Region: PRK05479 218494008066 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494008067 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 218494008068 HMMPfam hit to PF01450, Acetohydroxy acid isomeroreductase C-terminal, score 1.5e-81 218494008069 HMMPfam hit to PF07991, Acetohydroxy acid isomeroreductase, catalytic, score 1.9e-113 218494008070 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218494008071 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 218494008072 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 218494008073 putative valine binding site [chemical binding]; other site 218494008074 dimer interface [polypeptide binding]; other site 218494008075 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 218494008076 HMMPfam hit to PF01842, Amino acid-binding ACT, score 4.3e-13 218494008077 PS00430 TonB-dependent receptor proteins signature 1. 218494008078 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 218494008079 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 218494008080 PYR/PP interface [polypeptide binding]; other site 218494008081 dimer interface [polypeptide binding]; other site 218494008082 TPP binding site [chemical binding]; other site 218494008083 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 218494008084 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 218494008085 TPP-binding site [chemical binding]; other site 218494008086 dimer interface [polypeptide binding]; other site 218494008087 HMMPfam hit to PF02775, Thiamine pyrophosphate enzyme, C-terminal TPP-binding, score 2.7e-71 218494008088 PS00187 Thiamine pyrophosphate enzymes signature. 218494008089 HMMPfam hit to PF00205, Thiamine pyrophosphate enzyme, central region, score 1.1e-68 218494008090 HMMPfam hit to PF02776, Thiamine pyrophosphate enzyme, N-terminal TPP binding region, score 1.7e-97 218494008091 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 218494008092 Ligand binding site; other site 218494008093 Putative Catalytic site; other site 218494008094 DXD motif; other site 218494008095 GtrA-like protein; Region: GtrA; cl00971 218494008096 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 2.5e-11 218494008097 3 probable transmembrane helices predicted for SSU1683 by TMHMM2.0 at aa 233-255, 285-307 and 311-333 218494008098 Predicted periplasmic protein (DUF2233); Region: DUF2233; cl10481 218494008099 1 probable transmembrane helix predicted for SSU1684 by TMHMM2.0 at aa 7-26 218494008100 4 probable transmembrane helices predicted for SSU1685 by TMHMM2.0 at aa 13-35, 45-67, 74-96 and 109-131 218494008101 Dehydratase family; Region: ILVD_EDD; cl00340 218494008102 HMMPfam hit to PF00920, Dihydroxy-acid and 6-phosphogluconate dehydratase, score 0 218494008103 PS00886 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 1. 218494008104 PS00887 Dihydroxy-acid and 6-phosphogluconate dehydratases signature 2. 218494008105 Domain of unknown function DUF59; Region: DUF59; cl00941 218494008106 HMMPfam hit to PF01883, Protein of unknown function DUF59, score 4.8e-18 218494008107 CDS contains a frameshift after codon 76. Similar to Lactobacillus acidophilus hypothetical protein UniProt:Q5FK33 (EMBL:CP000033) (152 aa) fasta scores: E()=0.001, 22.689% id in 119 aa 218494008108 HMMPfam hit to PF01243, Pyridoxamine 5'-phosphate oxidase-related, FMN-binding core, score 0.0032 218494008109 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 218494008110 HMMPfam hit to PF00380, Ribosomal protein S9, score 7e-59 218494008111 PS00360 Ribosomal protein S9 signature. 218494008112 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 218494008113 23S rRNA interface [nucleotide binding]; other site 218494008114 L3 interface [polypeptide binding]; other site 218494008115 HMMPfam hit to PF00572, Ribosomal protein L13, score 2.1e-68 218494008116 PS00783 Ribosomal protein L13 signature. 218494008117 Probable gene remnant. Similar to the N-terminal region of Streptococcus pyogenes serotype M6 50S ribosomal protein L13 UniProt:Q5X9X3 (EMBL:CP000003) (183 aa) fasta scores: E()=0.00055, 76.923% id in 26 aa 218494008118 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 218494008119 HMMPfam hit to PF02645, DegV, score 5.2e-69 218494008120 YacP-like NYN domain; Region: NYN_YacP; cl01491 218494008121 HMMPfam hit to PF05991, Protein of unknown function DUF901, score 5.6e-76 218494008122 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 218494008123 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 218494008124 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 218494008125 HMMPfam hit to PF00588, tRNA/rRNA methyltransferase, SpoU, score 4.1e-61 218494008126 HMMPfam hit to PF08032, RNA 2-O ribose methyltransferase, substrate binding, score 7.5e-20 218494008127 HMMPfam hit to PF03793, PASTA, score 1e-09 218494008128 1 probable transmembrane helix predicted for SSU1697 by TMHMM2.0 at aa 108-127 218494008129 4 probable transmembrane helices predicted for SSU1698 by TMHMM2.0 at aa 4-25, 55-72, 77-99 and 106-128 218494008130 Predicted membrane protein [Function unknown]; Region: COG4129 218494008131 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 218494008132 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 218494008133 HMMPfam hit to PF06081, Protein of unknown function DUF939, bacterial, score 2.6e-132 218494008134 3 probable transmembrane helices predicted for SSU1699 by TMHMM2.0 at aa 10-41, 62-84 and 115-137 218494008135 2 probable transmembrane helices predicted for SSU1700 by TMHMM2.0 at aa 26-43 and 53-72 218494008136 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 218494008137 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 218494008138 Walker A/P-loop; other site 218494008139 ATP binding site [chemical binding]; other site 218494008140 Q-loop/lid; other site 218494008141 ABC transporter signature motif; other site 218494008142 Walker B; other site 218494008143 D-loop; other site 218494008144 H-loop/switch region; other site 218494008145 TOBE domain; Region: TOBE_2; cl01440 218494008146 HMMPfam hit to PF03459, Transport-associated OB, type 1, score 1.2e-08 218494008147 HMMPfam hit to PF00005, ABC transporter related, score 5.2e-55 218494008148 PS00211 ABC transporters family signature. 218494008149 PS00017 ATP/GTP-binding site motif A (P-loop). 218494008150 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 218494008151 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494008152 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 218494008153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218494008154 active site 218494008155 phosphorylation site [posttranslational modification] 218494008156 intermolecular recognition site; other site 218494008157 dimerization interface [polypeptide binding]; other site 218494008158 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 218494008159 HMMPfam hit to PF00165, Helix-turn-helix, AraC type, score 4.1e-12 218494008160 PS00041 Bacterial regulatory proteins, araC family signature. 218494008161 HMMPfam hit to PF00072, Response regulator receiver, score 1.9e-38 218494008162 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 218494008163 Histidine kinase; Region: His_kinase; pfam06580 218494008164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 218494008165 ATP binding site [chemical binding]; other site 218494008166 Mg2+ binding site [ion binding]; other site 218494008167 G-X-G motif; other site 218494008168 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 0.00011 218494008169 HMMPfam hit to PF06580, Histidine kinase internal region, score 9.2e-26 218494008170 HMMPfam hit to PF00672, Histidine kinase, HAMP region, score 0.0016 218494008171 2 probable transmembrane helices predicted for SSU1704 by TMHMM2.0 at aa 15-34 and 243-265 218494008172 4 probable transmembrane helices predicted for SSU1705 by TMHMM2.0 at aa 20-42, 72-94, 104-126 and 163-185 218494008173 Transposase; Region: DEDD_Tnp_IS110; pfam01548 218494008174 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 218494008175 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 218494008176 HMMPfam hit to PF02371, Transposase, IS116/IS110/IS902, score 1.2e-20 218494008177 HMMPfam hit to PF01548, Transposase, IS111A/IS1328/IS1533, score 7.2e-05 218494008178 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218494008179 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 218494008180 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 8.9e-07 218494008181 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494008182 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 218494008183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494008184 dimer interface [polypeptide binding]; other site 218494008185 conserved gate region; other site 218494008186 putative PBP binding loops; other site 218494008187 ABC-ATPase subunit interface; other site 218494008188 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.6e-13 218494008189 6 probable transmembrane helices predicted for SSU1708 by TMHMM2.0 at aa 21-43, 83-105, 118-140, 150-172, 193-215 and 275-297 218494008190 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 218494008191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494008192 dimer interface [polypeptide binding]; other site 218494008193 conserved gate region; other site 218494008194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 218494008195 ABC-ATPase subunit interface; other site 218494008196 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 2.1e-07 218494008197 6 probable transmembrane helices predicted for SSU1709 by TMHMM2.0 at aa 13-35, 83-105, 118-140, 160-182, 215-237 and 278-300 218494008198 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218494008199 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 218494008200 putative active site [active] 218494008201 HMMPfam hit to PF00728, Glycoside hydrolase, family 20, catalytic core, score 1.2e-17 218494008202 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 218494008203 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 218494008204 HMMPfam hit to PF00480, ROK, score 6.4e-13 218494008205 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 218494008206 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 218494008207 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 218494008208 HMMPfam hit to PF07748, Glycosyl hydrolases 38, C-terminal, score 1.5e-07 218494008209 HMMPfam hit to PF01074, Glycoside hydrolase, family 38, core, score 9.1e-35 218494008210 Protein of unknown function (DUF1237); Region: DUF1237; cl15402 218494008211 HMMPfam hit to PF06824, Uncharacterised conserved protein UCP028846, score 9.9e-301 218494008212 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 218494008213 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; cl15460 218494008214 HMMPfam hit to PF07971, Glycosyl hydrolase 92, score 2.2e-203 218494008215 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 218494008216 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 218494008217 active site 218494008218 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 218494008219 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 218494008220 G5 domain; Region: G5; pfam07501 218494008221 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494008222 HMMPfam hit to PF07523, Bacterial Ig-like, score 4e-10 218494008223 HMMPfam hit to PF07523, Bacterial Ig-like, score 0.025 218494008224 HMMPfam hit to PF00754, Coagulation factor 5/8 type, C-terminal, score 3.9e-08 218494008225 HMMPfam hit to PF03644, Glycoside hydrolase, family 85, score 1.9e-150 218494008226 1 probable transmembrane helix predicted for SSU1715 by TMHMM2.0 at aa 13-35 218494008227 HMMPfam hit to PF04650, YSIRK Gram-positive signal peptide, score 1.9e-11 218494008228 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 218494008229 active site 218494008230 metal binding site [ion binding]; metal-binding site 218494008231 dimerization interface [polypeptide binding]; other site 218494008232 HMMPfam hit to PF00636, Ribonuclease III, score 0.00022 218494008233 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 218494008234 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 218494008235 active site 218494008236 HIGH motif; other site 218494008237 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 218494008238 KMSKS motif; other site 218494008239 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 218494008240 tRNA binding surface [nucleotide binding]; other site 218494008241 anticodon binding site; other site 218494008242 HMMPfam hit to PF09190, Cysteinyl-tRNA synthetase, class Ia, DALR, score 7.2e-14 218494008243 HMMPfam hit to PF01406, Cysteinyl-tRNA synthetase, class Ia, N-terminal, score 1.2e-185 218494008244 2 probable transmembrane helices predicted for SSU1718 by TMHMM2.0 at aa 9-25 and 30-47 218494008245 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 218494008246 HMMPfam hit to PF01048, Nucleoside phosphorylase, score 6.5e-06 218494008247 serine O-acetyltransferase; Region: cysE; TIGR01172 218494008248 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 218494008249 trimer interface [polypeptide binding]; other site 218494008250 active site 218494008251 substrate binding site [chemical binding]; other site 218494008252 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 4.1 218494008253 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 2.6 218494008254 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 1.4 218494008255 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 218494008256 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 218494008257 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 218494008258 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 218494008259 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 218494008260 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 218494008261 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 218494008262 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 218494008263 RNA binding site [nucleotide binding]; other site 218494008264 HMMPfam hit to PF00575, S1, RNA binding, score 6.3e-22 218494008265 HMMPfam hit to PF00013, K Homology, type 1, score 7.1e-13 218494008266 HMMPfam hit to PF03725, Exoribonuclease, phosphorolytic domain 2, score 2.3e-26 218494008267 HMMPfam hit to PF01138, Exoribonuclease, phosphorolytic domain 1, score 5.4e-43 218494008268 HMMPfam hit to PF03726, Polynucleotide phosphorylase, phosphorolytic RNA-binding, bacterial/organelle-type, score 1.6e-11 218494008269 HMMPfam hit to PF03725, Exoribonuclease, phosphorolytic domain 2, score 2e-13 218494008270 HMMPfam hit to PF01138, Exoribonuclease, phosphorolytic domain 1, score 3.3e-29 218494008271 Predicted acetyltransferase [General function prediction only]; Region: COG3981 218494008272 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218494008273 Coenzyme A binding pocket [chemical binding]; other site 218494008274 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 0.0031 218494008275 CDS contains a frameshift around codon 258. Similar to Bacillus anthracis hypothetical protein UniProt:Q81UN9 (EMBL:AE017026) (354 aa) fasta scores: E()=5.9e-34, 36.950% id in 341 aa 218494008276 HMMPfam hit to PF05913, Protein of unknown function DUF871, prokaryotic, score 7.6e-14 218494008277 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 218494008278 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 218494008279 active site turn [active] 218494008280 phosphorylation site [posttranslational modification] 218494008281 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 218494008282 8 probable transmembrane helices predicted for SSU1725 by TMHMM2.0 at aa 122-144, 188-210, 223-245, 255-277, 298-320, 340-362, 400-422 and 442-464 218494008283 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 1.2e-37 218494008284 HMMPfam hit to PF00367, Phosphotransferase system, EIIB, score 1.5e-09 218494008285 PS01035 PTS EIIB domains cysteine phosphorylation site signature. 218494008286 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 218494008287 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 218494008288 putative active site [active] 218494008289 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 0.00078 218494008290 PS01272 Glucokinase regulatory protein family signature. 218494008291 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 218494008292 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494008293 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 218494008294 putative active site [active] 218494008295 HMMPfam hit to PF01418, Helix-turn-helix protein RpiR, score 1e-12 218494008296 Predicted helix-turn-helix motif with score 1960.000, SD 5.86 at aa 34-55, sequence MNIYQLADNAGVSTATISRISK 218494008297 HMMPfam hit to PF01380, Sugar isomerase (SIS), score 4.5e-29 218494008298 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 218494008299 16S/18S rRNA binding site [nucleotide binding]; other site 218494008300 S13e-L30e interaction site [polypeptide binding]; other site 218494008301 25S rRNA binding site [nucleotide binding]; other site 218494008302 HMMPfam hit to PF00312, Ribosomal protein S15, score 2.9e-34 218494008303 Permease family; Region: Xan_ur_permease; cl00967 218494008304 11 probable transmembrane helices predicted for SSU1729 by TMHMM2.0 at aa 41-63, 76-93, 103-125, 132-154, 169-186, 193-215, 242-264, 325-347, 352-374, 381-400 and 404-426 218494008305 HMMPfam hit to PF00860, Xanthine/uracil/vitamin C permease, score 4.7e-101 218494008306 PS01116 Xanthine/uracil permeases family signature. 218494008307 2 probable transmembrane helices predicted for SSU1731 by TMHMM2.0 at aa 7-26 and 107-124 218494008308 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 218494008309 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218494008310 RNA binding surface [nucleotide binding]; other site 218494008311 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 218494008312 active site 218494008313 uracil binding [chemical binding]; other site 218494008314 HMMPfam hit to PF00849, Pseudouridine synthase, score 4e-19 218494008315 PS01149 Rsu family of pseudouridine synthase signature. 218494008316 HMMPfam hit to PF01479, RNA-binding S4, score 4e-11 218494008317 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 218494008318 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 0.0061 218494008319 Probable gene remnant. Similar to the N-terminal region of Streptococcus pyogenes serotype M18 hypothetical protein SPYM18_1021 UniProt:Q8P178 (EMBL:AE010030) (213 aa) fasta scores: E()=8.3e-05, 44.643% id in 56 aa 218494008320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 218494008321 12 probable transmembrane helices predicted for SSU1735 by TMHMM2.0 at aa 9-27, 47-69, 76-98, 103-125, 132-154, 158-180, 209-231, 246-268, 273-292, 297-319, 328-350 and 365-382 218494008322 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 4e-39 218494008323 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 218494008324 active site 218494008325 catalytic residues [active] 218494008326 metal binding site [ion binding]; metal-binding site 218494008327 HMMPfam hit to PF01327, Formylmethionine deformylase, score 7.6e-91 218494008328 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 218494008329 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 218494008330 substrate binding site [chemical binding]; other site 218494008331 HMMPfam hit to PF00694, Aconitase A/isopropylmalate dehydratase small subunit, swivel, score 4.3e-57 218494008332 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 218494008333 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 218494008334 substrate binding site [chemical binding]; other site 218494008335 ligand binding site [chemical binding]; other site 218494008336 HMMPfam hit to PF00330, Aconitase/3-isopropylmalate dehydratase large subunit, alpha/beta/alpha, score 8.9e-190 218494008337 PS00450 Aconitase family signature 1. 218494008338 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 218494008339 tartrate dehydrogenase; Provisional; Region: PRK08194 218494008340 HMMPfam hit to PF00180, Isocitrate/isopropylmalate dehydrogenase, score 2.9e-191 218494008341 PS00470 Isocitrate and isopropylmalate dehydrogenases signature. 218494008342 2-isopropylmalate synthase; Validated; Region: PRK00915 218494008343 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 218494008344 active site 218494008345 catalytic residues [active] 218494008346 metal binding site [ion binding]; metal-binding site 218494008347 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 218494008348 HMMPfam hit to PF08502, LeuA allosteric (dimerisation) domain, score 3.8e-34 218494008349 HMMPfam hit to PF00682, Pyruvate carboxyltransferase, score 2.4e-132 218494008350 PS00816 Alpha-isopropylmalate and homocitrate synthases signature 2. 218494008351 PS00815 Alpha-isopropylmalate and homocitrate synthases signature 1. 218494008352 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 218494008353 HMMPfam hit to PF04226, Transglycosylase-associated protein, score 7.6e-12 218494008354 3 probable transmembrane helices predicted for SSU1742 by TMHMM2.0 at aa 4-21, 26-45 and 49-71 218494008355 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 218494008356 HMMPfam hit to PF02073, Peptidase M29, aminopeptidase II, score 5.7e-175 218494008357 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 218494008358 dimer interface [polypeptide binding]; other site 218494008359 FMN binding site [chemical binding]; other site 218494008360 HMMPfam hit to PF00881, Nitroreductase, score 0.001 218494008361 LemA family; Region: LemA; cl00742 218494008362 HMMPfam hit to PF04011, LemA, score 0.00015 218494008363 2 probable transmembrane helices predicted for SSU1745 by TMHMM2.0 at aa 14-36 218494008364 DNA polymerase III PolC; Validated; Region: polC; PRK00448 218494008365 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 218494008366 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 218494008367 generic binding surface II; other site 218494008368 generic binding surface I; other site 218494008369 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 218494008370 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 218494008371 active site 218494008372 substrate binding site [chemical binding]; other site 218494008373 catalytic site [active] 218494008374 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 218494008375 HMMPfam hit to PF07733, Bacterial DNA polymerase III, alpha subunit, score 2.5e-192 218494008376 HMMPfam hit to PF02811, PHP, C-terminal, score 7.1e-36 218494008377 HMMPfam hit to PF00929, Exonuclease, RNase T and DNA polymerase III, score 2.7e-41 218494008378 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 1.1e-07 218494008379 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 218494008380 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 218494008381 HMMPfam hit to PF02733, Dak kinase, score 4.1e-74 218494008382 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 218494008383 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494008384 HMMPfam hit to PF00440, Transcriptional regulator, TetR-like, DNA-binding, bacterial/archaeal, score 0.0002 218494008385 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 218494008386 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 218494008387 HMMPfam hit to PF02733, Dak kinase, score 2.5e-110 218494008388 DAK2 domain; Region: Dak2; cl03685 218494008389 HMMPfam hit to PF02734, Dak phosphatase, score 1.3e-75 218494008390 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 218494008391 HMMPfam hit to PF03610, Phosphotransferase system, fructose subfamily IIA component, score 6.1e-33 218494008392 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 218494008393 amphipathic channel; other site 218494008394 Asn-Pro-Ala signature motifs; other site 218494008395 HMMPfam hit to PF00230, Major intrinsic protein, score 4e-24 218494008396 6 probable transmembrane helices predicted for SSU1752 by TMHMM2.0 at aa 4-26, 39-61, 81-103, 130-152, 162-184 and 211-233 218494008397 PS00221 MIP family signature. 218494008398 prolyl-tRNA synthetase; Provisional; Region: PRK09194 218494008399 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 218494008400 dimer interface [polypeptide binding]; other site 218494008401 motif 1; other site 218494008402 active site 218494008403 motif 2; other site 218494008404 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 218494008405 putative deacylase active site [active] 218494008406 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 218494008407 active site 218494008408 motif 3; other site 218494008409 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 218494008410 anticodon binding site; other site 218494008411 HMMPfam hit to PF03129, Anticodon-binding, score 1.5e-23 218494008412 HMMPfam hit to PF04073, YbaK/prolyl-tRNA synthetase associated region, score 7.5e-28 218494008413 HMMPfam hit to PF00587, Aminoacyl-tRNA synthetase, class II (G, H, P and S), score 1.2e-50 218494008414 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 218494008415 RIP metalloprotease RseP; Region: TIGR00054 218494008416 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 218494008417 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 218494008418 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 218494008419 putative substrate binding region [chemical binding]; other site 218494008420 4 probable transmembrane helices predicted for SSU1754 by TMHMM2.0 at aa 4-26, 176-198, 341-363 and 393-415 218494008421 HMMPfam hit to PF02163, Peptidase M50, score 1.6e-95 218494008422 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218494008423 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 218494008424 HMMPfam hit to PF01148, Phosphatidate cytidylyltransferase, score 2.6e-93 218494008425 PS01315 Phosphatidate cytidylyltransferase signature. 218494008426 7 probable transmembrane helices predicted for SSU1755 by TMHMM2.0 at aa 10-41, 48-70, 85-104, 111-129, 139-156, 177-195 and 199-221 218494008427 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 218494008428 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 218494008429 catalytic residue [active] 218494008430 putative FPP diphosphate binding site; other site 218494008431 putative FPP binding hydrophobic cleft; other site 218494008432 dimer interface [polypeptide binding]; other site 218494008433 putative IPP diphosphate binding site; other site 218494008434 HMMPfam hit to PF01255, Di-trans-poly-cis-decaprenylcistransferase, score 6.5e-104 218494008435 PS01066 Undecaprenyl pyrophosphate synthetase family signature. 218494008436 Preprotein translocase subunit; Region: YajC; cl00806 218494008437 HMMPfam hit to PF02699, YajC, score 2.3e-17 218494008438 1 probable transmembrane helix predicted for SSU1757 by TMHMM2.0 at aa 4-21 218494008439 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 218494008440 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 218494008441 GDP-binding site [chemical binding]; other site 218494008442 ACT binding site; other site 218494008443 IMP binding site; other site 218494008444 HMMPfam hit to PF00709, Adenylosuccinate synthetase, score 3.4e-302 218494008445 PS00513 Adenylosuccinate synthetase active site. 218494008446 PS01266 Adenylosuccinate synthetase GTP-binding site. 218494008447 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 218494008448 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl01099 218494008449 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 218494008450 HMMPfam hit to PF04262, Glutamate--cysteine ligase, score 1e-83 218494008451 PS00030 Eukaryotic RNA-binding region RNP-1 signature. 218494008452 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 218494008453 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 218494008454 generic binding surface II; other site 218494008455 generic binding surface I; other site 218494008456 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 218494008457 generic binding surface I; other site 218494008458 generic binding surface II; other site 218494008459 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 218494008460 putative catalytic site [active] 218494008461 putative metal binding site [ion binding]; other site 218494008462 putative phosphate binding site [ion binding]; other site 218494008463 2 probable transmembrane helices predicted for SSU1760 by TMHMM2.0 at aa 7-29 and 1016-1033 218494008464 HMMPfam hit to PF03372, Endonuclease/exonuclease/phosphatase, score 2.8e-18 218494008465 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494008466 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 218494008467 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 218494008468 dimerization interface [polypeptide binding]; other site 218494008469 domain crossover interface; other site 218494008470 redox-dependent activation switch; other site 218494008471 HMMPfam hit to PF01430, Hsp33 protein, score 4.6e-146 218494008472 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 218494008473 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 218494008474 FMN binding site [chemical binding]; other site 218494008475 active site 218494008476 catalytic residues [active] 218494008477 substrate binding site [chemical binding]; other site 218494008478 HMMPfam hit to PF01207, Dihydrouridine synthase, DuS, score 1.2e-93 218494008479 PS01136 Uncharacterized protein family UPF0034 signature. 218494008480 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 218494008481 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 218494008482 nudix motif; other site 218494008483 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 2.2e-13 218494008484 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 218494008485 6 probable transmembrane helices predicted for SSU1764 by TMHMM2.0 at aa 34-56, 76-93, 100-119, 123-142, 162-184 and 217-234 218494008486 HMMPfam hit to PF04973, Nicotinamide mononucleotide transporter PnuC, score 1.6e-13 218494008487 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 218494008488 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 218494008489 active site 218494008490 nucleotide binding site [chemical binding]; other site 218494008491 HIGH motif; other site 218494008492 KMSKS motif; other site 218494008493 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; cl01238 218494008494 PS00017 ATP/GTP-binding site motif A (P-loop). 218494008495 PS01070 DNA/RNA non-specific endonucleases active site. 218494008496 HMMPfam hit to PF01467, Cytidylyltransferase, score 2.9e-05 218494008497 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 218494008498 Clp amino terminal domain; Region: Clp_N; pfam02861 218494008499 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218494008500 Walker A motif; other site 218494008501 ATP binding site [chemical binding]; other site 218494008502 Walker B motif; other site 218494008503 arginine finger; other site 218494008504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218494008505 Walker A motif; other site 218494008506 ATP binding site [chemical binding]; other site 218494008507 Walker B motif; other site 218494008508 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 218494008509 HMMPfam hit to PF07724, ATPase AAA-2, score 1.1e-101 218494008510 PS00871 Chaperonins clpA/B signature 2. 218494008511 PS00017 ATP/GTP-binding site motif A (P-loop). 218494008512 HMMPfam hit to PF00004, AAA ATPase, core, score 1.1e-08 218494008513 PS00870 Chaperonins clpA/B signature 1. 218494008514 PS00017 ATP/GTP-binding site motif A (P-loop). 218494008515 HMMPfam hit to PF02861, Clp, N-terminal, score 0.26 218494008516 HMMPfam hit to PF02861, Clp, N-terminal, score 0.00029 218494008517 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 218494008518 HMMPfam hit to PF05848, Firmicute transcriptional repressor of class III stress genes, score 6.8e-82 218494008519 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218494008520 Predicted helix-turn-helix motif with score 1554.000, SD 4.48 at aa 26-47, sequence LRRSELASRFEVVPSQINYVIK 218494008521 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 218494008522 catalytic residues [active] 218494008523 HMMPfam hit to PF05768, Glutaredoxin 2, score 0.0028 218494008524 elongation factor Ts; Provisional; Region: tsf; PRK09377 218494008525 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 218494008526 Elongation factor TS; Region: EF_TS; pfam00889 218494008527 Elongation factor TS; Region: EF_TS; pfam00889 218494008528 HMMPfam hit to PF00889, Translation elongation factor EFTs/EF1B, dimerisation, score 5.1e-55 218494008529 HMMPfam hit to PF00627, Ubiquitin-associated_translation elongation factor EF1B, N-terminal, score 3.1e-12 218494008530 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 218494008531 rRNA interaction site [nucleotide binding]; other site 218494008532 S8 interaction site; other site 218494008533 putative laminin-1 binding site; other site 218494008534 HMMPfam hit to PF00318, Ribosomal protein S2, score 6.1e-99 218494008535 PS00963 Ribosomal protein S2 signature 2. 218494008536 PS00962 Ribosomal protein S2 signature 1. 218494008537 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494008538 active site 218494008539 PS00017 ATP/GTP-binding site motif A (P-loop). 218494008540 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 218494008541 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 218494008542 putative active site [active] 218494008543 catalytic triad [active] 218494008544 PA_2: Protease-associated (PA) domain subgroup 2. A subgroup of PA-domain containing proteins. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is...; Region: PA_2; cd04819 218494008545 PA/protease or protease-like domain interface [polypeptide binding]; other site 218494008546 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 218494008547 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 218494008548 2 probable transmembrane helices predicted for SSU1773 by TMHMM2.0 at aa 21-40 and 1666-1688 218494008549 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494008550 HMMPfam hit to PF06280, Peptidase S8A, DUF1034 C-terminal, score 1.5e-20 218494008551 HMMPfam hit to PF00082, Peptidase S8 and S53, subtilisin, kexin, sedolisin, score 1e-38 218494008552 PS00138 Serine proteases, subtilase family, serine active site. 218494008553 HMMPfam hit to PF02225, Protease-associated PA, score 0.0023 218494008554 PS00137 Serine proteases, subtilase family, histidine active site. 218494008555 PS00136 Serine proteases, subtilase family, aspartic acid active site. 218494008556 HMMPfam hit to PF04650, YSIRK Gram-positive signal peptide, score 6.9e-08 218494008557 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 218494008558 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 218494008559 putative homodimer interface [polypeptide binding]; other site 218494008560 KOW motif; Region: KOW; cl00354 218494008561 HMMPfam hit to PF00467, KOW, score 2.4e-08 218494008562 HMMPfam hit to PF02357, Transcription antitermination protein, NusG, N-terminal, score 6.7e-50 218494008563 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 218494008564 HMMPfam hit to PF00584, Protein secE/sec61-gamma protein, score 0.0014 218494008565 1 probable transmembrane helix predicted for SSU1775 by TMHMM2.0 at aa 26-48 218494008566 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 218494008567 HMMPfam hit to PF00471, Ribosomal protein L33, score 2.5e-11 218494008568 Transglycosylase; Region: Transgly; cl07896 218494008569 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 218494008570 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 218494008571 HMMPfam hit to PF00905, Penicillin-binding protein, transpeptidase, score 3.6e-41 218494008572 HMMPfam hit to PF00912, Glycosyl transferase, family 51, score 9.6e-82 218494008573 1 probable transmembrane helix predicted for SSU1777 by TMHMM2.0 at aa 59-78 218494008574 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 218494008575 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494008576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494008577 HMMPfam hit to PF07992, FAD-dependent pyridine nucleotide-disulphide oxidoreductase, score 6.4e-26 218494008578 1 probable transmembrane helix predicted for SSU1778 by TMHMM2.0 at aa 7-24 218494008579 HMMPfam hit to PF00070, Pyridine nucleotide-disulphide oxidoreductase, NAD-binding region, score 5.8e-11 218494008580 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 218494008581 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 218494008582 active site 218494008583 HMMPfam hit to PF00849, Pseudouridine synthase, score 7.4e-45 218494008584 PS01129 Rlu family of pseudouridine synthase signature. 218494008585 pur operon repressor; Provisional; Region: PRK09213 218494008586 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 218494008587 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 218494008588 HMMPfam hit to PF00156, Phosphoribosyltransferase, score 4e-20 218494008589 HMMPfam hit to PF09182, Bacterial purine repressor, N-terminal, score 8.6e-44 218494008590 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 218494008591 Phosphotransferase enzyme family; Region: APH; pfam01636 218494008592 active site 218494008593 substrate binding site [chemical binding]; other site 218494008594 ATP binding site [chemical binding]; other site 218494008595 HMMPfam hit to PF01636, Aminoglycoside phosphotransferase, score 3e-24 218494008596 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 218494008597 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 218494008598 generic binding surface II; other site 218494008599 generic binding surface I; other site 218494008600 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 218494008601 Zn2+ binding site [ion binding]; other site 218494008602 Mg2+ binding site [ion binding]; other site 218494008603 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 2.6e-05 218494008604 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 0.013 218494008605 RmuC family; Region: RmuC; pfam02646 218494008606 HMMPfam hit to PF02646, RmuC, score 8.6e-132 218494008607 1 probable transmembrane helix predicted for SSU1783 by TMHMM2.0 at aa 3-20 218494008608 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 218494008609 Thiamine pyrophosphokinase; Region: TPK; cd07995 218494008610 active site 218494008611 dimerization interface [polypeptide binding]; other site 218494008612 thiamine binding site [chemical binding]; other site 218494008613 HMMPfam hit to PF04265, Thiamin pyrophosphokinase, vitamin B1-binding region, score 2.7e-11 218494008614 HMMPfam hit to PF04263, Thiamin pyrophosphokinase, catalytic region, score 6.1e-33 218494008615 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 218494008616 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 218494008617 substrate binding site [chemical binding]; other site 218494008618 hexamer interface [polypeptide binding]; other site 218494008619 metal binding site [ion binding]; metal-binding site 218494008620 HMMPfam hit to PF00834, Ribulose-phosphate 3-epimerase, score 2.1e-102 218494008621 PS01085 Ribulose-phosphate 3-epimerase family signature 1. 218494008622 GTPase RsgA; Reviewed; Region: PRK00098 218494008623 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854 218494008624 GTPase/OB domain interface [polypeptide binding]; other site 218494008625 GTPase/Zn-binding domain interface [polypeptide binding]; other site 218494008626 GTP/Mg2+ binding site [chemical binding]; other site 218494008627 G4 box; other site 218494008628 G1 box; other site 218494008629 Switch I region; other site 218494008630 G2 box; other site 218494008631 G3 box; other site 218494008632 Switch II region; other site 218494008633 HMMPfam hit to PF03193, GTPase EngC, score 2.7e-150 218494008634 PS00017 ATP/GTP-binding site motif A (P-loop). 218494008635 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 218494008636 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 218494008637 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 218494008638 Walker A/P-loop; other site 218494008639 ATP binding site [chemical binding]; other site 218494008640 Q-loop/lid; other site 218494008641 ABC transporter signature motif; other site 218494008642 Walker B; other site 218494008643 D-loop; other site 218494008644 H-loop/switch region; other site 218494008645 HMMPfam hit to PF00005, ABC transporter related, score 1.9e-26 218494008646 PS00211 ABC transporters family signature. 218494008647 PS00675 Sigma-54 interaction domain ATP-binding region A signature. 218494008648 PS00017 ATP/GTP-binding site motif A (P-loop). 218494008649 5 probable transmembrane helices predicted for SSU1787 by TMHMM2.0 at aa 7-25, 40-62, 117-139, 144-163 and 231-253 218494008650 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218494008651 Radical SAM superfamily; Region: Radical_SAM; pfam04055 218494008652 FeS/SAM binding site; other site 218494008653 HMMPfam hit to PF04055, Radical SAM, score 8.6e-18 218494008654 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 218494008655 non-specific DNA binding site [nucleotide binding]; other site 218494008656 salt bridge; other site 218494008657 sequence-specific DNA binding site [nucleotide binding]; other site 218494008658 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 218494008659 HMMPfam hit to PF01381, Helix-turn-helix type 3, score 7.7e-09 218494008660 1 probable transmembrane helix predicted for SSU1790 by TMHMM2.0 at aa 29-51 218494008661 Sulfatase; Region: Sulfatase; cl10460 218494008662 HMMPfam hit to PF00884, Sulphatase, score 3.1e-50 218494008663 11 probable transmembrane helices predicted for SSU1791 by TMHMM2.0 at aa 12-30, 35-57, 70-92, 105-124, 137-159, 182-204, 217-236, 251-273, 278-297, 320-342 and 363-380 218494008664 10 probable transmembrane helices predicted for SSU1792 by TMHMM2.0 at aa 12-31, 98-120, 127-149, 190-212, 225-247, 273-292, 299-321, 336-358, 367-384 and 547-569 218494008665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218494008666 S-adenosylmethionine binding site [chemical binding]; other site 218494008667 HMMPfam hit to PF00398, Ribosomal RNA adenine methylase transferase, score 6.6e-74 218494008668 PS01131 Ribosomal RNA adenine dimethylases signature. 218494008669 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 218494008670 HMMPfam hit to PF08002, Protein of unknown function DUF1697, score 1.5e-16 218494008671 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 218494008672 HMMPfam hit to PF06769, Addiction module toxin, Txe/YoeB, score 1.1e-51 218494008673 Phd_YefM; Region: PhdYeFM; cl09153 218494008674 HMMPfam hit to PF02604, Protein of unknown function DUF172, score 3.7e-22 218494008675 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 218494008676 putative active site [active] 218494008677 nucleotide binding site [chemical binding]; other site 218494008678 nudix motif; other site 218494008679 putative metal binding site [ion binding]; other site 218494008680 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 6.6e-15 218494008681 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218494008682 PS00893 mutT domain signature. 218494008683 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 218494008684 HMMPfam hit to PF05016, Plasmid stabilization system, score 7.8e-07 218494008685 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 218494008686 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 218494008687 putative active site [active] 218494008688 putative metal binding site [ion binding]; other site 218494008689 HMMPfam hit to PF01751, TOPRIM, score 1.9e-07 218494008690 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 218494008691 active site 218494008692 HMMPfam hit to PF01026, Deoxyribonuclease, TatD-related, score 3.4e-119 218494008693 PS01137 Uncharacterized protein family UPF0006 signature 1. 218494008694 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 218494008695 HMMPfam hit to PF00468, Ribosomal protein L34, score 1.9e-19 218494008696 PS00784 Ribosomal protein L34 signature. 218494008697 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 218494008698 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 218494008699 G-X-X-G motif; other site 218494008700 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 218494008701 RxxxH motif; other site 218494008702 HMMPfam hit to PF01424, Single-stranded nucleic acid binding R3H, score 1.1e-14 218494008703 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 218494008704 HMMPfam hit to PF02096, 60 kDa inner membrane insertion protein, score 3e-50 218494008705 5 probable transmembrane helices predicted for SSU1805 by TMHMM2.0 at aa 7-29, 44-73, 126-145, 165-184 and 197-219 218494008706 Ribonuclease P; Region: Ribonuclease_P; cl00457 218494008707 HMMPfam hit to PF00825, Bacterial ribonuclease P protein, score 2.9e-31 218494008708 PS00648 Bacterial ribonuclease P protein component signature. 218494008709 argininosuccinate lyase; Provisional; Region: PRK00855 218494008710 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 218494008711 active sites [active] 218494008712 tetramer interface [polypeptide binding]; other site 218494008713 HMMPfam hit to PF00206, Fumarate lyase, score 7.5e-87 218494008714 PS00017 ATP/GTP-binding site motif A (P-loop). 218494008715 PS00163 Fumarate lyases signature. 218494008716 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 218494008717 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 218494008718 ANP binding site [chemical binding]; other site 218494008719 Substrate Binding Site II [chemical binding]; other site 218494008720 Substrate Binding Site I [chemical binding]; other site 218494008721 HMMPfam hit to PF00764, Argininosuccinate synthase, score 1.6e-233 218494008722 PS00565 Argininosuccinate synthase signature 2. 218494008723 PS00564 Argininosuccinate synthase signature 1. 218494008724 5 probable transmembrane helices predicted for SSU1809 by TMHMM2.0 at aa 15-37, 44-66, 81-100, 112-134 and 149-171 218494008725 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 218494008726 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494008727 3H domain; Region: 3H; pfam02829 218494008728 HMMPfam hit to PF02829, 3H, score 1.1e-16 218494008729 HMMPfam hit to PF08279, Helix-turn-helix, type 11, score 3.2e-15 218494008730 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 218494008731 dimer interface [polypeptide binding]; other site 218494008732 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 218494008733 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 218494008734 active site 218494008735 metal binding site [ion binding]; metal-binding site 218494008736 HMMPfam hit to PF06983, 3-demethylubiquinone-9 3-O-methyltransferase, score 1e-15 218494008737 HMMPfam hit to PF06983, 3-demethylubiquinone-9 3-O-methyltransferase, score 1.6e-37 218494008738 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218494008739 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 218494008740 nudix motif; other site 218494008741 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 1.5e-11 218494008742 PS00893 mutT domain signature. 218494008743 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 218494008744 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 218494008745 HMMPfam hit to PF02574, Homocysteine S-methyltransferase, score 1.3e-88 218494008746 Predicted helix-turn-helix motif with score 1042.000, SD 2.74 at aa 211-232, sequence TSIEKIAELVNSSEQILAVGLN 218494008747 Amino acid permease; Region: AA_permease; cl00524 218494008748 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 218494008749 HMMPfam hit to PF00324, Amino acid permease-associated region, score 1e-131 218494008750 12 probable transmembrane helices predicted for SSU1814 by TMHMM2.0 at aa 21-43, 53-75, 88-109, 129-151, 158-180, 195-217, 246-268, 288-310, 337-359, 363-385, 406-428 and 438-455 218494008751 PS00218 Amino acid permeases signature. 218494008752 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 218494008753 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 218494008754 active site 218494008755 HIGH motif; other site 218494008756 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 218494008757 active site 218494008758 KMSKS motif; other site 218494008759 HMMPfam hit to PF00749, Glutamyl/glutaminyl-tRNA synthetase, class Ic, score 2.3e-162 218494008760 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218494008761 H+ Antiporter protein; Region: 2A0121; TIGR00900 218494008762 8 probable transmembrane helices predicted for SSU1816 by TMHMM2.0 at aa 7-29, 44-66, 87-109, 171-193, 240-262, 277-299, 312-334 and 381-415 218494008763 HMMPfam hit to PF07690, Major facilitator superfamily MFS-1, score 2.4e-05 218494008764 4 probable transmembrane helices predicted for SSU1817 by TMHMM2.0 at aa 5-19, 23-45, 52-74 and 79-96 218494008765 LytTr DNA-binding domain; Region: LytTR; cl04498 218494008766 HMMPfam hit to PF04397, LytTr DNA-binding region, score 3.7e-24 218494008767 Protein of unknown function DUF124; Region: DUF124; cl00884 218494008768 HMMPfam hit to PF01987, Protein of unknown function DUF124, score 3.5e-84 218494008769 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 218494008770 active site clefts [active] 218494008771 zinc binding site [ion binding]; other site 218494008772 dimer interface [polypeptide binding]; other site 218494008773 HMMPfam hit to PF00484, Carbonic anhydrase, score 1.5e-16 218494008774 DNA repair protein RadA; Provisional; Region: PRK11823 218494008775 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 218494008776 Walker A motif/ATP binding site; other site 218494008777 ATP binding site [chemical binding]; other site 218494008778 Walker B motif; other site 218494008779 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 218494008780 PS00017 ATP/GTP-binding site motif A (P-loop). 218494008781 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 218494008782 HMMPfam hit to PF00300, Phosphoglycerate mutase, score 1.5e-21 218494008783 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 218494008784 trimer interface [polypeptide binding]; other site 218494008785 active site 218494008786 HMMPfam hit to PF00692, DeoxyUTP pyrophosphatase, score 7.1e-14 218494008787 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 218494008788 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 218494008789 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 218494008790 Walker A/P-loop; other site 218494008791 ATP binding site [chemical binding]; other site 218494008792 Q-loop/lid; other site 218494008793 ABC transporter signature motif; other site 218494008794 Walker B; other site 218494008795 D-loop; other site 218494008796 H-loop/switch region; other site 218494008797 HMMPfam hit to PF00005, ABC transporter related, score 3.9e-52 218494008798 PS00017 ATP/GTP-binding site motif A (P-loop). 218494008799 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 1.7e-31 218494008800 5 probable transmembrane helices predicted for SSU1824 by TMHMM2.0 at aa 16-33, 78-100, 153-170, 174-196 and 253-275 218494008801 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 218494008802 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 218494008803 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494008804 Walker A/P-loop; other site 218494008805 ATP binding site [chemical binding]; other site 218494008806 Q-loop/lid; other site 218494008807 ABC transporter signature motif; other site 218494008808 Walker B; other site 218494008809 D-loop; other site 218494008810 H-loop/switch region; other site 218494008811 HMMPfam hit to PF00005, ABC transporter related, score 2.1e-51 218494008812 PS00211 ABC transporters family signature. 218494008813 PS00017 ATP/GTP-binding site motif A (P-loop). 218494008814 6 probable transmembrane helices predicted for SSU1825 by TMHMM2.0 at aa 12-34, 49-71, 123-145, 150-172, 227-249 and 269-291 218494008815 HMMPfam hit to PF00664, ABC transporter, transmembrane region, score 5.3e-25 218494008816 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494008817 HMMPfam hit to PF01047, Bacterial regulatory protein, MarR, score 4.7e-11 218494008818 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 218494008819 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494008820 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 218494008821 HMMPfam hit to PF01210, NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal, score 6e-79 218494008822 HMMPfam hit to PF07479, NAD-dependent glycerol-3-phosphate dehydrogenase, C-terminal, score 9.9e-74 218494008823 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 218494008824 active site 218494008825 tetramer interface; other site 218494008826 HMMPfam hit to PF00483, Nucleotidyl transferase, score 3.4e-27 218494008827 Rhomboid family; Region: Rhomboid; cl11446 218494008828 6 probable transmembrane helices predicted for SSU1829 by TMHMM2.0 at aa 9-31, 62-84, 97-115, 119-138, 158-189 and 204-223 218494008829 HMMPfam hit to PF01694, Peptidase S54, rhomboid, score 6.4e-39 218494008830 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 218494008831 HMMPfam hit to PF01812, 5-formyltetrahydrofolate cyclo-ligase, score 5.1e-42 218494008832 PS00215 Mitochondrial energy transfer proteins signature. 218494008833 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 218494008834 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 218494008835 metal binding site [ion binding]; metal-binding site 218494008836 putative dimer interface [polypeptide binding]; other site 218494008837 HMMPfam hit to PF01546, Peptidase M20, score 1.8e-44 218494008838 HMMPfam hit to PF07687, Peptidase M20, dimerisation, score 7.6e-05 218494008839 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapD_N; pfam08503 218494008840 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 218494008841 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 218494008842 trimer interface [polypeptide binding]; other site 218494008843 active site 218494008844 substrate binding site [chemical binding]; other site 218494008845 CoA binding site [chemical binding]; other site 218494008846 PS00101 Hexapeptide-repeat containing-transferases signature. 218494008847 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 4.7 218494008848 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.35 218494008849 PS00101 Hexapeptide-repeat containing-transferases signature. 218494008850 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.34 218494008851 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.18 218494008852 HMMPfam hit to PF00132, Bacterial transferase hexapeptide repeat, score 0.029 218494008853 HMMPfam hit to PF08503, Tetrahydrodipicolinate succinyltransferase N-terminal, score 6.6e-39 218494008854 1 probable transmembrane helix predicted for SSU1834 by TMHMM2.0 at aa 27-49 218494008855 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 218494008856 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 218494008857 active site 218494008858 metal binding site [ion binding]; metal-binding site 218494008859 HMMPfam hit to PF00149, Metallophosphoesterase, score 4e-14 218494008860 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 218494008861 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 218494008862 active site 218494008863 dimer interface [polypeptide binding]; other site 218494008864 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 218494008865 dimer interface [polypeptide binding]; other site 218494008866 active site 218494008867 HMMPfam hit to PF00342, Phosphoglucose isomerase (PGI), score 6.5e-152 218494008868 PS00765 Phosphoglucose isomerase signature 1. 218494008869 PS00017 ATP/GTP-binding site motif A (P-loop). 218494008870 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 218494008871 nucleoside/Zn binding site; other site 218494008872 dimer interface [polypeptide binding]; other site 218494008873 catalytic motif [active] 218494008874 HMMPfam hit to PF00383, CMP/dCMP deaminase, zinc-binding, score 8.8e-36 218494008875 PS00903 Cytidine and deoxycytidylate deaminases zinc-binding region signature. 218494008876 PS00213 Lipocalin signature. 218494008877 transketolase; Reviewed; Region: PRK05899 218494008878 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 218494008879 TPP-binding site [chemical binding]; other site 218494008880 dimer interface [polypeptide binding]; other site 218494008881 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 218494008882 PYR/PP interface [polypeptide binding]; other site 218494008883 dimer interface [polypeptide binding]; other site 218494008884 TPP binding site [chemical binding]; other site 218494008885 HMMPfam hit to PF02780, Transketolase, C-terminal, score 2.4e-09 218494008886 HMMPfam hit to PF02779, Transketolase, central region, score 4.4e-71 218494008887 PS00802 Transketolase signature 2. 218494008888 HMMPfam hit to PF00456, Transketolase, N-terminal, score 9.7e-220 218494008889 PS00801 Transketolase signature 1. 218494008890 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 218494008891 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 218494008892 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494008893 PRD domain; Region: PRD; cl15445 218494008894 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 218494008895 P-loop; other site 218494008896 active site 218494008897 phosphorylation site [posttranslational modification] 218494008898 HMMPfam hit to PF00874, PRD, score 9.8e-15 218494008899 PS00215 Mitochondrial energy transfer proteins signature. 218494008900 HMMPfam hit to PF00874, PRD, score 5e-09 218494008901 HMMPfam hit to PF08279, Helix-turn-helix, type 11, score 0.0002 218494008902 Predicted helix-turn-helix motif with score 1152.000, SD 3.11 at aa 107-128, sequence VTIERLMELTEVSRNTVLNDLN 218494008903 2 probable transmembrane helices predicted for SSU1842 by TMHMM2.0 at aa 13-35 and 103-121 218494008904 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 218494008905 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 218494008906 intersubunit interface [polypeptide binding]; other site 218494008907 active site 218494008908 Zn2+ binding site [ion binding]; other site 218494008909 HMMPfam hit to PF00596, Class II aldolase/adducin, N-terminal, score 4e-95 218494008910 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 218494008911 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 218494008912 AP (apurinic/apyrimidinic) site pocket; other site 218494008913 DNA interaction; other site 218494008914 Metal-binding active site; metal-binding site 218494008915 HMMPfam hit to PF01261, Xylose isomerase-type TIM barrel, score 7.7e-49 218494008916 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 218494008917 active site 218494008918 dimer interface [polypeptide binding]; other site 218494008919 magnesium binding site [ion binding]; other site 218494008920 HMMPfam hit to PF00215, Orotidine 5'-phosphate decarboxylase, core, score 2.5e-52 218494008921 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218494008922 active site 218494008923 phosphorylation site [posttranslational modification] 218494008924 HMMPfam hit to PF00359, Phosphotransferase system, phosphoenolpyruvate-dependent sugar EIIA 2, score 4.5e-32 218494008925 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 218494008926 P-loop; other site 218494008927 active site 218494008928 phosphorylation site [posttranslational modification] 218494008929 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 1e-26 218494008930 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 218494008931 11 probable transmembrane helices predicted for SSU1848 by TMHMM2.0 at aa 15-34, 41-63, 104-123, 135-157, 162-179, 239-261, 281-303, 342-364, 368-387, 399-421 and 436-458 218494008932 HMMPfam hit to PF04215, sugar-specific permease, SgaT/UlaA, score 3.3e-227 218494008933 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 218494008934 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 218494008935 carbohydrate binding site [chemical binding]; other site 218494008936 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 218494008937 carbohydrate binding site [chemical binding]; other site 218494008938 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 218494008939 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 218494008940 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 218494008941 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 218494008942 carbohydrate binding site [chemical binding]; other site 218494008943 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 218494008944 carbohydrate binding site [chemical binding]; other site 218494008945 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 218494008946 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 218494008947 G5 domain; Region: G5; pfam07501 218494008948 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494008949 HMMPfam hit to PF07501, G5, score 9.2e-13 218494008950 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 7.2e-12 218494008951 HMMPfam hit to PF02922, Glycoside hydrolase, family 13, N-terminal, score 3e-15 218494008952 HMMPfam hit to PF03714, Bacterial pullanase-associated protein, score 8.4e-41 218494008953 HMMPfam hit to PF03714, Bacterial pullanase-associated protein, score 1.8e-34 218494008954 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 6.8e-67 218494008955 HMMPfam hit to PF03714, Bacterial pullanase-associated protein, score 2.2e-32 218494008956 HMMPfam hit to PF03714, Bacterial pullanase-associated protein, score 4.4e-22 218494008957 1 probable transmembrane helix predicted for SSU1849 by TMHMM2.0 at aa 20-42 218494008958 HMMPfam hit to PF04650, YSIRK Gram-positive signal peptide, score 1.7e-08 218494008959 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218494008960 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218494008961 DNA binding site [nucleotide binding] 218494008962 domain linker motif; other site 218494008963 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 218494008964 ligand binding site [chemical binding]; other site 218494008965 dimerization interface [polypeptide binding]; other site 218494008966 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 5.4e-05 218494008967 PS00017 ATP/GTP-binding site motif A (P-loop). 218494008968 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 1.6e-13 218494008969 Predicted helix-turn-helix motif with score 2288.000, SD 6.98 at aa 2-23, sequence TTLADVARLANVSKMTVSRVIN 218494008970 PS00356 Bacterial regulatory proteins, lacI family signature. 218494008971 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 218494008972 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 218494008973 Walker A/P-loop; other site 218494008974 ATP binding site [chemical binding]; other site 218494008975 Q-loop/lid; other site 218494008976 ABC transporter signature motif; other site 218494008977 Walker B; other site 218494008978 D-loop; other site 218494008979 H-loop/switch region; other site 218494008980 HMMPfam hit to PF00005, ABC transporter related, score 1.7e-58 218494008981 PS00211 ABC transporters family signature. 218494008982 PS00017 ATP/GTP-binding site motif A (P-loop). 218494008983 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 218494008984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494008985 dimer interface [polypeptide binding]; other site 218494008986 conserved gate region; other site 218494008987 putative PBP binding loops; other site 218494008988 ABC-ATPase subunit interface; other site 218494008989 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.5e-24 218494008990 4 probable transmembrane helices predicted for SSU1852 by TMHMM2.0 at aa 23-45, 58-80, 84-106 and 187-206 218494008991 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218494008992 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 218494008993 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 218494008994 substrate binding pocket [chemical binding]; other site 218494008995 membrane-bound complex binding site; other site 218494008996 hinge residues; other site 218494008997 HMMPfam hit to PF00497, Bacterial extracellular solute-binding protein, family 3, score 4.7e-93 218494008998 PS01039 Bacterial extracellular solute-binding proteins, family 3 signature. 218494008999 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494009000 NlpC/P60 family; Region: NLPC_P60; cl11438 218494009001 HMMPfam hit to PF05257, Cysteine, histidine-dependent amidohydrolase/peptidase, score 8e-38 218494009002 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 218494009003 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 218494009004 10 probable transmembrane helices predicted for SSU1855 by TMHMM2.0 at aa 27-49, 72-94, 101-123, 166-188, 209-231, 251-273, 280-302, 322-341, 379-401 and 421-443 218494009005 HMMPfam hit to PF02378, Phosphotransferase system, EIIC, score 5.5e-57 218494009006 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 218494009007 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 218494009008 active site 218494009009 methionine cluster; other site 218494009010 phosphorylation site [posttranslational modification] 218494009011 metal binding site [ion binding]; metal-binding site 218494009012 HMMPfam hit to PF02255, Phosphotransferase system, lactose/cellobiose-specific IIA subunit, score 6.7e-42 218494009013 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 218494009014 active site 218494009015 P-loop; other site 218494009016 phosphorylation site [posttranslational modification] 218494009017 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 4.4e-40 218494009018 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 218494009019 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494009020 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494009021 PRD domain; Region: PRD; cl15445 218494009022 PRD domain; Region: PRD; cl15445 218494009023 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 218494009024 P-loop; other site 218494009025 active site 218494009026 phosphorylation site [posttranslational modification] 218494009027 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 218494009028 active site 218494009029 phosphorylation site [posttranslational modification] 218494009030 HMMPfam hit to PF02302, Phosphotransferase system, lactose/cellobiose-specific IIB subunit, score 3.7e-05 218494009031 HMMPfam hit to PF00874, PRD, score 2.6e-13 218494009032 HMMPfam hit to PF00874, PRD, score 2e-14 218494009033 HMMPfam hit to PF05043, M trans-acting positive regulator, score 2.9e-08 218494009034 HMMPfam hit to PF08279, Helix-turn-helix, type 11, score 3.6e-13 218494009035 Predicted helix-turn-helix motif with score 1230.000, SD 3.38 at aa 21-42, sequence VPSIELAKVLSVSDRTVRTYIH 218494009036 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 218494009037 HMMPfam hit to PF05913, Protein of unknown function DUF871, prokaryotic, score 1.1e-158 218494009038 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 218494009039 HMMPfam hit to PF00232, Glycoside hydrolase, family 1, score 5.4e-111 218494009040 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 218494009041 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 218494009042 NAD binding site [chemical binding]; other site 218494009043 sugar binding site [chemical binding]; other site 218494009044 divalent metal binding site [ion binding]; other site 218494009045 tetramer (dimer of dimers) interface [polypeptide binding]; other site 218494009046 dimer interface [polypeptide binding]; other site 218494009047 HMMPfam hit to PF02056, Glycoside hydrolase, family 4, score 7.4e-132 218494009048 PS01324 Glycosyl hydrolases family 4 signature. 218494009049 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 218494009050 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 218494009051 HIGH motif; other site 218494009052 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 218494009053 active site 218494009054 KMSKS motif; other site 218494009055 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 218494009056 tRNA binding surface [nucleotide binding]; other site 218494009057 HMMPfam hit to PF08264, Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding, score 6.6e-12 218494009058 HMMPfam hit to PF00133, Aminoacyl-tRNA synthetase, class Ia, score 6.5e-13 218494009059 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218494009060 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 218494009061 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 218494009062 active site 218494009063 Zn binding site [ion binding]; other site 218494009064 HMMPfam hit to PF01431, Peptidase M13, neprilysin, score 2.5e-77 218494009065 PS00142 Neutral zinc metallopeptidases, zinc-binding region signature. 218494009066 HMMPfam hit to PF05649, Peptidase M13, score 7.6e-166 218494009067 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218494009068 ABC-ATPase subunit interface; other site 218494009069 dimer interface [polypeptide binding]; other site 218494009070 putative PBP binding regions; other site 218494009071 8 probable transmembrane helices predicted for SSU1865 by TMHMM2.0 at aa 4-26, 33-50, 55-72, 84-106, 131-153, 185-207, 222-244 and 251-269 218494009072 HMMPfam hit to PF00950, ABC-3, score 3.4e-16 218494009073 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 218494009074 ABC-ATPase subunit interface; other site 218494009075 dimer interface [polypeptide binding]; other site 218494009076 putative PBP binding regions; other site 218494009077 9 probable transmembrane helices predicted for SSU1866 by TMHMM2.0 at aa 10-32, 39-58, 62-84, 91-110, 139-161, 182-201, 205-224, 231-253 and 257-279 218494009078 HMMPfam hit to PF00950, ABC-3, score 1.3e-36 218494009079 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 218494009080 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 218494009081 HMMPfam hit to PF00005, ABC transporter related, score 3e-52 218494009082 PS00211 ABC transporters family signature. 218494009083 PS00017 ATP/GTP-binding site motif A (P-loop). 218494009084 1 probable transmembrane helix predicted for SSU1868 by TMHMM2.0 at aa 21-40 218494009085 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 218494009086 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 218494009087 intersubunit interface [polypeptide binding]; other site 218494009088 HMMPfam hit to PF01297, Periplasmic solute binding protein, score 8e-72 218494009089 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494009090 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 218494009091 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494009092 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 218494009093 FeoA domain; Region: FeoA; cl00838 218494009094 HMMPfam hit to PF01325, Iron dependent repressor, score 5.2e-09 218494009095 HMMPfam hit to PF02742, Iron dependent repressor, score 1.6e-18 218494009096 HMMPfam hit to PF04023, Ferrous iron transporter, FeoA subunit, score 2.2e-06 218494009097 2 probable transmembrane helices predicted for SSU1871 by TMHMM2.0 at aa 38-57 and 67-89 218494009098 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 218494009099 7 probable transmembrane helices predicted for SSU1872 by TMHMM2.0 at aa 7-29, 39-56, 76-98, 120-142, 155-172, 176-193 and 200-222 218494009100 HMMPfam hit to PF02517, Abortive infection protein, score 2.9e-11 218494009101 Probable gene remnant. Similar to the C-terminal region of Streptococcus pneumoniae hypothetical protein SP0181 UniProt:Q97SY2 (EMBL:AE007333) (225 aa) fasta scores: E()=0.0015, 34.328% id in 67 aa 218494009102 Probable gene remnant. Similar to the N-terminal region of Streptococcus pyogenes response regulator protein SilA UniProt:Q8P262 (EMBL:AF493605) (249 aa) fasta scores: E()=9.5e-42, 57.619% id in 210 aa. CDS contains a frameshift after codon 164 218494009103 2 probable transmembrane helices predicted for SSU1873 by TMHMM2.0 at aa 7-29 and 44-61 218494009104 HMMPfam hit to PF02517, Abortive infection protein, score 3.7e-08 218494009105 HMMPfam hit to PF00072, Response regulator receiver, score 1.4e-07 218494009106 1 probable transmembrane helix predicted for SSU1875 by TMHMM2.0 at aa 20-42 218494009107 2 probable transmembrane helices predicted for SSU1876 by TMHMM2.0 at aa 12-31 and 35-52 218494009108 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 218494009109 putative active site [active] 218494009110 dimerization interface [polypeptide binding]; other site 218494009111 putative tRNAtyr binding site [nucleotide binding]; other site 218494009112 HMMPfam hit to PF02580, D-tyrosyl-tRNA(Tyr) deacylase, score 1.4e-88 218494009113 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 218494009114 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 218494009115 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 218494009116 synthetase active site [active] 218494009117 NTP binding site [chemical binding]; other site 218494009118 metal binding site [ion binding]; metal-binding site 218494009119 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 218494009120 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 218494009121 HMMPfam hit to PF01842, Amino acid-binding ACT, score 7.6e-05 218494009122 HMMPfam hit to PF02824, TGS, score 9.9e-29 218494009123 HMMPfam hit to PF04607, RelA/SpoT, score 1.8e-48 218494009124 HMMPfam hit to PF01966, Metal-dependent phosphohydrolase, HD region, subdomain, score 1.2e-11 218494009125 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK11907 218494009126 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 218494009127 active site 218494009128 metal binding site [ion binding]; metal-binding site 218494009129 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 218494009130 HMMPfam hit to PF00149, Metallophosphoesterase, score 2.1e-16 218494009131 PS00786 5'-nucleotidase signature 2. 218494009132 HMMPfam hit to PF02872, 5'-Nucleotidase, C-terminal, score 9.8e-57 218494009133 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 4.2e-05 218494009134 PS00343 Gram-positive cocci surface proteins 'anchoring' hexapeptide. 218494009135 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 218494009136 active site 218494009137 catalytic site [active] 218494009138 2 probable transmembrane helices predicted for SSU1881 by TMHMM2.0 at aa 4-26 and 246-268 218494009139 HMMPfam hit to PF04203, Peptidase C60, sortase A and B, score 1.5e-36 218494009140 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 218494009141 active site 218494009142 catalytic site [active] 218494009143 2 probable transmembrane helices predicted for SSU1882 by TMHMM2.0 at aa 20-39 and 252-274 218494009144 HMMPfam hit to PF04203, Peptidase C60, sortase A and B, score 7.9e-66 218494009145 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 218494009146 active site 218494009147 catalytic site [active] 218494009148 1 probable transmembrane helix predicted for SSU1883 by TMHMM2.0 at aa 234-256 218494009149 HMMPfam hit to PF04203, Peptidase C60, sortase A and B, score 4.2e-62 218494009150 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 218494009151 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 218494009152 2 probable transmembrane helices predicted for SSU1885 by TMHMM2.0 at aa 7-25 and 259-281 218494009153 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 2.2e-22 218494009154 CDS contains a frameshift after codon 813. Similar to Streptococcus pneumoniae cell wall surface anchor family protein UniProt:Q97SC2 (EMBL:AE007358) (665 aa) fasta scores: E()=1e-49, 35.662% id in 687 aa 218494009155 HMMPfam hit to PF00746, Surface protein from Gram-positive cocci, anchor region, score 1.4e-05 218494009156 1 probable transmembrane helix predicted for SSU1886 by TMHMM2.0 at aa 335-357 218494009157 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 2.1e-11 218494009158 1 probable transmembrane helix predicted for SSU1887 by TMHMM2.0 at aa 7-24 218494009159 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 218494009160 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 218494009161 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 218494009162 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 218494009163 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 218494009164 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 218494009165 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 218494009166 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B repeat...; Region: CollagenBindB; cl14619 218494009167 1 probable transmembrane helix predicted for SSU1888 by TMHMM2.0 at aa 1334-1356 218494009168 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 7.3e-08 218494009169 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 6.4e-08 218494009170 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 9.6e-05 218494009171 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 0.026 218494009172 HMMPfam hit to PF00754, Coagulation factor 5/8 type, C-terminal, score 8.1e-15 218494009173 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 4e-09 218494009174 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 0.00029 218494009175 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 5.8e-10 218494009176 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 9.2e-09 218494009177 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 2.7e-18 218494009178 Possible surface-anchored protein, contains unusual LYXTG motif. Possible pseudogene. CDS is possible N-terminal region of large surface-anchored protein, upstrean CDS, SSU1888 is possible C-terminal region. 218494009179 HMMPfam hit to PF05738, Collagen-binding surface protein Cna-like, B region, score 2.1e-09 218494009180 1 probable transmembrane helix predicted for SSU1889 by TMHMM2.0 at aa 9-31 218494009181 1 probable transmembrane helix predicted for SSU1890 by TMHMM2.0 at aa 10-32 218494009182 Protein of unknown function (DUF554); Region: DUF554; cl00784 218494009183 1 probable transmembrane helix predicted for SSU1892 by TMHMM2.0 at aa 5-27 218494009184 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 218494009185 HMMPfam hit to PF04452, Protein of unknown function DUF558, methyltransferase predicted, score 1.5e-93 218494009186 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 218494009187 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 218494009188 S-adenosylmethionine binding site [chemical binding]; other site 218494009189 HMMPfam hit to PF06325, Ribosomal L11 methyltransferase, score 1.3e-165 218494009190 ASC-1 homology domain, subfamily similar to Pyrococcus furiosus Pf0470. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_PF0470_like; cd06555 218494009191 HMMPfam hit to PF07060, ProFAR isomerase-like, score 3.9e-15 218494009192 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 218494009193 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 218494009194 HMMPfam hit to PF03819, NTP pyrophosphohydrolase MazG, catalytic core, score 6.5e-05 218494009195 recombination factor protein RarA; Reviewed; Region: PRK13342 218494009196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 218494009197 Walker A motif; other site 218494009198 ATP binding site [chemical binding]; other site 218494009199 Walker B motif; other site 218494009200 arginine finger; other site 218494009201 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 218494009202 HMMPfam hit to PF00004, AAA ATPase, core, score 1.8e-19 218494009203 PS00017 ATP/GTP-binding site motif A (P-loop). 218494009204 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 218494009205 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 218494009206 FeS/SAM binding site; other site 218494009207 HMMPfam hit to PF04055, Radical SAM, score 5.5e-05 218494009208 Predicted acetyltransferase [General function prediction only]; Region: COG3981 218494009209 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 218494009210 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 218494009211 active site 218494009212 metal binding site [ion binding]; metal-binding site 218494009213 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 218494009214 HMMPfam hit to PF02872, 5'-Nucleotidase, C-terminal, score 1.7e-10 218494009215 HMMPfam hit to PF00149, Metallophosphoesterase, score 5.2e-14 218494009216 PS00785 5'-nucleotidase signature 1. 218494009217 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 218494009218 ATP cone domain; Region: ATP-cone; pfam03477 218494009219 Class III ribonucleotide reductase; Region: RNR_III; cd01675 218494009220 effector binding site; other site 218494009221 active site 218494009222 Zn binding site [ion binding]; other site 218494009223 glycine loop; other site 218494009224 HMMPfam hit to PF01228, Formate C-acetyltransferase glycine radical, score 1.2e-25 218494009225 PS00850 Glycine radical signature. 218494009226 HMMPfam hit to PF03477, ATP-cone, score 1.1e-19 218494009227 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 218494009228 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 218494009229 HMMPfam hit to PF01609, Transposase, IS4-like, score 1.6e-18 218494009230 2 probable transmembrane helices predicted for SSU1905 by TMHMM2.0 at aa 7-26 and 36-53 218494009231 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 218494009232 4 probable transmembrane helices predicted for SSU1906 by TMHMM2.0 at aa 5-27, 49-71, 84-106 and 110-132 218494009233 LytTr DNA-binding domain; Region: LytTR; cl04498 218494009234 HMMPfam hit to PF04397, LytTr DNA-binding region, score 5.2e-18 218494009235 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 218494009236 MutS domain I; Region: MutS_I; pfam01624 218494009237 MutS domain II; Region: MutS_II; pfam05188 218494009238 MutS family domain IV; Region: MutS_IV; pfam05190 218494009239 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 218494009240 Walker A/P-loop; other site 218494009241 ATP binding site [chemical binding]; other site 218494009242 Q-loop/lid; other site 218494009243 ABC transporter signature motif; other site 218494009244 Walker B; other site 218494009245 D-loop; other site 218494009246 H-loop/switch region; other site 218494009247 HMMPfam hit to PF00488, DNA mismatch repair protein MutS, C-terminal, score 4.4e-152 218494009248 PS00486 DNA mismatch repair proteins mutS family signature. 218494009249 PS00237 G-protein coupled receptors signature. 218494009250 PS00017 ATP/GTP-binding site motif A (P-loop). 218494009251 HMMPfam hit to PF05192, MutS III, score 4.5e-85 218494009252 HMMPfam hit to PF05190, MutS IV, score 1.2e-37 218494009253 HMMPfam hit to PF05188, MutS II, score 2.9e-28 218494009254 HMMPfam hit to PF01624, DNA mismatch repair protein MutS, N-terminal, score 8.8e-73 218494009255 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 218494009256 arginine repressor; Region: argR_whole; TIGR01529 218494009257 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 218494009258 HMMPfam hit to PF02863, Arginine repressor, score 3.3e-20 218494009259 HMMPfam hit to PF01316, Arginine repressor, score 1.7e-23 218494009260 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 218494009261 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 218494009262 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 218494009263 active site 218494009264 HIGH motif; other site 218494009265 KMSK motif region; other site 218494009266 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 218494009267 tRNA binding surface [nucleotide binding]; other site 218494009268 anticodon binding site; other site 218494009269 HMMPfam hit to PF03485, Arginyl tRNA synthetase, class Ic, N-terminal, score 2.6e-30 218494009270 HMMPfam hit to PF00750, Arginyl-tRNA synthetase, class Ic, core, score 4.3e-102 218494009271 HMMPfam hit to PF05746, DALR anticodon binding, score 2.8e-47 218494009272 NlpC/P60 family; Region: NLPC_P60; cl11438 218494009273 Bacterial SH3 domain; Region: SH3_3; cl02551 218494009274 Bacterial SH3 domain; Region: SH3_3; cl02551 218494009275 HMMPfam hit to PF05257, Cysteine, histidine-dependent amidohydrolase/peptidase, score 1e-19 218494009276 HMMPfam hit to PF08460, SH3, type-5 bacterial, score 1.8e-29 218494009277 HMMPfam hit to PF08460, SH3, type-5 bacterial, score 8.5e-22 218494009278 4 probable transmembrane helices predicted for SSU1912 by TMHMM2.0 at aa 7-29, 63-85, 92-114 and 129-151 218494009279 2 probable transmembrane helices predicted for SSU1913 by TMHMM2.0 at aa 7-29 and 33-55 218494009280 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 218494009281 HMMPfam hit to PF02446, Glycoside hydrolase, family 77, score 1e-225 218494009282 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 218494009283 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 218494009284 HMMPfam hit to PF01547, Bacterial extracellular solute-binding protein, family 1, score 4e-42 218494009285 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494009286 PS01037 Bacterial extracellular solute-binding proteins, family 1 signature. 218494009287 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 218494009288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494009289 dimer interface [polypeptide binding]; other site 218494009290 conserved gate region; other site 218494009291 putative PBP binding loops; other site 218494009292 ABC-ATPase subunit interface; other site 218494009293 HMMPfam hit to PF05154, TM2, score 9.3e-08 218494009294 8 probable transmembrane helices predicted for SSU1916 by TMHMM2.0 at aa 31-50, 70-92, 129-151, 193-215, 227-246, 289-311, 332-354 and 398-420 218494009295 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 1.3e-28 218494009296 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218494009297 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 218494009298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 218494009299 dimer interface [polypeptide binding]; other site 218494009300 conserved gate region; other site 218494009301 putative PBP binding loops; other site 218494009302 ABC-ATPase subunit interface; other site 218494009303 5 probable transmembrane helices predicted for SSU1917 by TMHMM2.0 at aa 26-48, 85-107, 119-141, 151-168 and 253-275 218494009304 HMMPfam hit to PF00528, Binding-protein-dependent transport systems inner membrane component, score 8.9e-23 218494009305 PS00402 Binding-protein-dependent transport systems inner membrane comp. sign. 218494009306 Predicted integral membrane protein [Function unknown]; Region: COG5521 218494009307 3 probable transmembrane helices predicted for SSU1918 by TMHMM2.0 at aa 170-192, 208-230 and 235-252 218494009308 Transcriptional regulators [Transcription]; Region: PurR; COG1609 218494009309 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 218494009310 DNA binding site [nucleotide binding] 218494009311 domain linker motif; other site 218494009312 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 218494009313 putative dimerization interface [polypeptide binding]; other site 218494009314 putative ligand binding site [chemical binding]; other site 218494009315 HMMPfam hit to PF00356, Bacterial regulatory protein, LacI, score 3.9e-12 218494009316 Predicted helix-turn-helix motif with score 2283.000, SD 6.96 at aa 3-24, sequence ATIKDVAKLAGVSPSTVTRVIQ 218494009317 PS00356 Bacterial regulatory proteins, lacI family signature. 218494009318 HMMPfam hit to PF00532, Periplasmic binding protein/LacI transcriptional regulator, score 5.7e-11 218494009319 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 218494009320 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 218494009321 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 218494009322 HMMPfam hit to PF02922, Glycoside hydrolase, family 13, N-terminal, score 1.5e-16 218494009323 HMMPfam hit to PF00128, Glycosyl hydrolase, family 13, catalytic region, score 5e-11 218494009324 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 218494009325 HMMPfam hit to PF07972, Ribonucleotide reductase Class Ib, NrdI, score 5.1e-57 218494009326 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 218494009327 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 218494009328 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 218494009329 HMMPfam hit to PF02588, Protein of unknown function DUF161, score 1.4e-25 218494009330 5 probable transmembrane helices predicted for SSU1922 by TMHMM2.0 at aa 39-58, 73-95, 107-129, 139-161 and 182-204 218494009331 HMMPfam hit to PF02588, Protein of unknown function DUF161, score 3.4e-19 218494009332 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 218494009333 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 218494009334 dimer interface [polypeptide binding]; other site 218494009335 anticodon binding site; other site 218494009336 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 218494009337 homodimer interface [polypeptide binding]; other site 218494009338 motif 1; other site 218494009339 active site 218494009340 motif 2; other site 218494009341 GAD domain; Region: GAD; pfam02938 218494009342 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 218494009343 motif 3; other site 218494009344 HMMPfam hit to PF00152, Aminoacyl-tRNA synthetase, class II (D, K and N), score 2.9e-216 218494009345 PS00339 Aminoacyl-transfer RNA synthetases class-II signature 2. 218494009346 HMMPfam hit to PF02938, GAD, score 4.6e-37 218494009347 PS00179 Aminoacyl-transfer RNA synthetases class-II signature 1. 218494009348 HMMPfam hit to PF01336, Nucleic acid binding, OB-fold, tRNA/helicase-type, score 9e-24 218494009349 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 218494009350 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 218494009351 Coenzyme A binding pocket [chemical binding]; other site 218494009352 HMMPfam hit to PF00583, GCN5-related N-acetyltransferase, score 1.1e-12 218494009353 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 218494009354 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 218494009355 active site 218494009356 catalytic tetrad [active] 218494009357 HMMPfam hit to PF00248, Aldo/keto reductase, score 3.2e-30 218494009358 Predicted helix-turn-helix motif with score 1563.000, SD 4.51 at aa 235-256, sequence QTIEEIAERYNVSHETIVVAWI 218494009359 PS00136 Serine proteases, subtilase family, aspartic acid active site. 218494009360 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 218494009361 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 218494009362 active site 218494009363 HMMPfam hit to PF00535, Glycosyl transferase, family 2, score 5.9e-34 218494009364 Probable beta-xylosidase; Provisional; Region: PLN03080 218494009365 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 218494009366 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 218494009367 HMMPfam hit to PF01915, Glycoside hydrolase, family 3, C-terminal, score 2e-57 218494009368 PS00225 Crystallins beta and gamma 'Greek key' motif signature. 218494009369 HMMPfam hit to PF00933, Glycoside hydrolase, family 3, N-terminal, score 2.1e-106 218494009370 PS00775 Glycosyl hydrolases family 3 active site. 218494009371 PS00017 ATP/GTP-binding site motif A (P-loop). 218494009372 4 probable transmembrane helices predicted for SSU1928 by TMHMM2.0 at aa 20-42, 62-81, 98-120 and 135-157 218494009373 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 218494009374 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 218494009375 4 probable transmembrane helices predicted for SSU1929 by TMHMM2.0 at aa 9-28, 38-60, 80-102 and 935-956 218494009376 HMMPfam hit to PF00933, Glycoside hydrolase, family 3, N-terminal, score 1.7e-57 218494009377 PS00775 Glycosyl hydrolases family 3 active site. 218494009378 HMMPfam hit to PF01915, Glycoside hydrolase, family 3, C-terminal, score 2.6e-36 218494009379 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 218494009380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 218494009381 active site 218494009382 phosphorylation site [posttranslational modification] 218494009383 intermolecular recognition site; other site 218494009384 dimerization interface [polypeptide binding]; other site 218494009385 LytTr DNA-binding domain; Region: LytTR; cl04498 218494009386 HMMPfam hit to PF00072, Response regulator receiver, score 3.9e-11 218494009387 HMMPfam hit to PF04397, LytTr DNA-binding region, score 9.3e-17 218494009388 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 218494009389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 218494009390 7 probable transmembrane helices predicted for SSU1931 by TMHMM2.0 at aa 10-29, 38-55, 60-82, 95-117, 122-141, 161-183 and 193-210 218494009391 HMMPfam hit to PF02518, ATP-binding region, ATPase-like, score 0.00026 218494009392 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 218494009393 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 218494009394 active site 218494009395 metal binding site [ion binding]; metal-binding site 218494009396 HMMPfam hit to PF00149, Metallophosphoesterase, score 1.8e-13 218494009397 1 probable transmembrane helix predicted for SSU1932 by TMHMM2.0 at aa 5-22 218494009398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494009399 FAD binding domain; Region: FAD_binding_2; pfam00890 218494009400 HMMPfam hit to PF00890, Fumarate reductase/succinate dehydrogenase flavoprotein, N-terminal, score 5.6e-119 218494009401 1 probable transmembrane helix predicted for SSU1933 by TMHMM2.0 at aa 5-24 218494009402 PS00013 Prokaryotic membrane lipoprotein lipid attachment site. 218494009403 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 218494009404 catalytic residues [active] 218494009405 1 probable transmembrane helix predicted for SSU1934 by TMHMM2.0 at aa 5-27 218494009406 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 218494009407 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 218494009408 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 218494009409 RNA binding surface [nucleotide binding]; other site 218494009410 HMMPfam hit to PF01479, RNA-binding S4, score 4.8e-24 218494009411 PS00632 Ribosomal protein S4 signature. 218494009412 HMMPfam hit to PF00163, Ribosomal protein S4, score 6.9e-26 218494009413 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 218494009414 HMMPfam hit to PF06257, Protein of unknown function DUF1021, score 6.2e-35 218494009415 replicative DNA helicase; Provisional; Region: PRK05748 218494009416 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 218494009417 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 218494009418 Walker A motif; other site 218494009419 ATP binding site [chemical binding]; other site 218494009420 Walker B motif; other site 218494009421 DNA binding loops [nucleotide binding] 218494009422 HMMPfam hit to PF03796, DNA helicase, DnaB-like, C-terminal, score 2.4e-127 218494009423 PS00017 ATP/GTP-binding site motif A (P-loop). 218494009424 HMMPfam hit to PF00772, DNA helicase, DnaB-like, N-terminal, score 1.7e-42 218494009425 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 218494009426 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 218494009427 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 218494009428 HMMPfam hit to PF03948, Ribosomal protein L9, score 9.1e-15 218494009429 HMMPfam hit to PF01281, Ribosomal protein L9, score 3.2e-19 218494009430 PS00651 Ribosomal protein L9 signature. 218494009431 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 218494009432 DHH family; Region: DHH; pfam01368 218494009433 DHHA1 domain; Region: DHHA1; pfam02272 218494009434 HMMPfam hit to PF02272, Phosphoesterase, DHHA1, score 8.9e-12 218494009435 HMMPfam hit to PF01368, Phosphoesterase, RecJ-like, score 1.3e-42 218494009436 2 probable transmembrane helices predicted for SSU1940 by TMHMM2.0 at aa 6-25 and 30-52 218494009437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 218494009438 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 218494009439 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 218494009440 HMMPfam hit to PF01134, Glucose-inhibited division protein A, score 1.9e-265 218494009441 PS01281 Glucose inhibited division protein A family signature 2. 218494009442 PS01280 Glucose inhibited division protein A family signature 1. 218494009443 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 218494009444 nudix motif; other site 218494009445 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 6.9e-14 218494009446 PS00893 mutT domain signature. 218494009447 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 218494009448 nudix motif; other site 218494009449 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 1.1e-18 218494009450 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 218494009451 nudix motif; other site 218494009452 HMMPfam hit to PF00293, NUDIX hydrolase, core, score 7.1e-16 218494009453 PS00893 mutT domain signature. 218494009454 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 218494009455 HMMPfam hit to PF01638, Helix-turn-helix, HxlR type, score 1.5e-49 218494009456 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 218494009457 HMMPfam hit to PF07366, Protein of unknown function DUF1486, score 4.2e-05 218494009458 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 218494009459 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 218494009460 HMMPfam hit to PF03054, tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase, score 2.5e-227 218494009461 PS00070 Aldehyde dehydrogenases cysteine active site. 218494009462 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 218494009463 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 218494009464 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 218494009465 putative L-serine binding site [chemical binding]; other site 218494009466 HMMPfam hit to PF03315, Serine dehydratase beta chain, score 5.2e-55 218494009467 HMMPfam hit to PF01842, Amino acid-binding ACT, score 9.2e-10 218494009468 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 218494009469 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 218494009470 HMMPfam hit to PF03313, Serine dehydratase alpha chain, score 8.6e-110 218494009471 PS00017 ATP/GTP-binding site motif A (P-loop). 218494009472 PS00867 Carbamoyl-phosphate synthase subdomain signature 2. 218494009473 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 218494009474 putative peptidoglycan binding site; other site 218494009475 HMMPfam hit to PF01476, Peptidoglycan-binding LysM, score 2e-15 218494009476 1 probable transmembrane helix predicted for SSU1950 by TMHMM2.0 at aa 21-43 218494009477 Cobalt transport protein; Region: CbiQ; cl00463 218494009478 4 probable transmembrane helices predicted for SSU1951 by TMHMM2.0 at aa 35-57, 64-86, 106-128 and 243-262 218494009479 HMMPfam hit to PF02361, Cobalt transport protein, score 1.6e-61 218494009480 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 218494009481 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 218494009482 Walker A/P-loop; other site 218494009483 ATP binding site [chemical binding]; other site 218494009484 Q-loop/lid; other site 218494009485 ABC transporter signature motif; other site 218494009486 Walker B; other site 218494009487 D-loop; other site 218494009488 H-loop/switch region; other site 218494009489 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 218494009490 HMMPfam hit to PF00005, ABC transporter related, score 4.2e-53 218494009491 PS00211 ABC transporters family signature. 218494009492 PS00017 ATP/GTP-binding site motif A (P-loop). 218494009493 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 218494009494 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 218494009495 Walker A/P-loop; other site 218494009496 ATP binding site [chemical binding]; other site 218494009497 Q-loop/lid; other site 218494009498 ABC transporter signature motif; other site 218494009499 Walker B; other site 218494009500 D-loop; other site 218494009501 H-loop/switch region; other site 218494009502 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 218494009503 HMMPfam hit to PF00005, ABC transporter related, score 3.1e-61 218494009504 PS00211 ABC transporters family signature. 218494009505 PS00017 ATP/GTP-binding site motif A (P-loop). 218494009506 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 218494009507 HMMPfam hit to PF01066, CDP-alcohol phosphatidyltransferase, score 1e-34 218494009508 3 probable transmembrane helices predicted for SSU1954 by TMHMM2.0 at aa 21-43, 75-97 and 137-159 218494009509 PS00379 CDP-alcohol phosphatidyltransferases signature. 218494009510 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 218494009511 1 probable transmembrane helix predicted for SSU1955 by TMHMM2.0 at aa 108-130 218494009512 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 218494009513 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 218494009514 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 218494009515 HMMPfam hit to PF05193, Peptidase M16, C-terminal, score 1.1e-18 218494009516 HMMPfam hit to PF00675, Peptidase M16, N-terminal, score 1.2e-18 218494009517 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 218494009518 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 218494009519 HMMPfam hit to PF05193, Peptidase M16, C-terminal, score 1.8e-25 218494009520 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 218494009521 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 218494009522 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 218494009523 Walker A/P-loop; other site 218494009524 ATP binding site [chemical binding]; other site 218494009525 Q-loop/lid; other site 218494009526 ABC transporter signature motif; other site 218494009527 Walker B; other site 218494009528 D-loop; other site 218494009529 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494009530 ABC transporter signature motif; other site 218494009531 Walker B; other site 218494009532 D-loop; other site 218494009533 H-loop/switch region; other site 218494009534 HMMPfam hit to PF02463, SMC protein, N-terminal, score 7.5e-08 218494009535 PS00017 ATP/GTP-binding site motif A (P-loop). 218494009536 PS00618 RecF protein signature 2. 218494009537 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 218494009538 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 218494009539 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 218494009540 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 218494009541 active site 218494009542 HMMPfam hit to PF00478, IMP dehydrogenase/GMP reductase, score 9.6e-243 218494009543 PS00487 IMP dehydrogenase / GMP reductase signature. 218494009544 HMMPfam hit to PF00571, Cystathionine beta-synthase, core, score 2.9e-28 218494009545 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 218494009546 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 218494009547 active site 218494009548 HIGH motif; other site 218494009549 dimer interface [polypeptide binding]; other site 218494009550 KMSKS motif; other site 218494009551 HMMPfam hit to PF00579, Aminoacyl-tRNA synthetase, class Ib, score 1.2e-84 218494009552 PS00178 Aminoacyl-transfer RNA synthetases class-I signature. 218494009553 Uncharacterized conserved protein [Function unknown]; Region: COG1284 218494009554 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 218494009555 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 218494009556 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 218494009557 6 probable transmembrane helices predicted for SSU1962 by TMHMM2.0 at aa 7-26, 30-47, 54-76, 103-122, 142-164 and 168-185 218494009558 HMMPfam hit to PF02588, Protein of unknown function DUF161, score 2.4e-16 218494009559 HMMPfam hit to PF02588, Protein of unknown function DUF161, score 1.5e-16 218494009560 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 218494009561 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 218494009562 Walker A/P-loop; other site 218494009563 ATP binding site [chemical binding]; other site 218494009564 Q-loop/lid; other site 218494009565 ABC transporter signature motif; other site 218494009566 Walker B; other site 218494009567 D-loop; other site 218494009568 H-loop/switch region; other site 218494009569 ABC transporter; Region: ABC_tran_2; pfam12848 218494009570 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 218494009571 HMMPfam hit to PF00005, ABC transporter related, score 3e-45 218494009572 PS00017 ATP/GTP-binding site motif A (P-loop). 218494009573 HMMPfam hit to PF00005, ABC transporter related, score 6.9e-23 218494009574 PS00211 ABC transporters family signature. 218494009575 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 218494009576 CrcB-like protein; Region: CRCB; cl09114 218494009577 12 probable transmembrane helices predicted for SSU1965 by TMHMM2.0 at aa 12-34, 75-97, 154-176, 191-213, 226-248, 288-310, 317-334, 349-371, 376-398, 408-427, 434-456 and 829-851 218494009578 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 218494009579 6 probable transmembrane helices predicted for SSU1966 by TMHMM2.0 at aa 12-34, 57-79, 91-113, 117-136, 175-194 and 199-216 218494009580 HMMPfam hit to PF06912, Protein of unknown function DUF1275, score 2e-65 218494009581 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 218494009582 HMMPfam hit to PF02590, Protein of unknown function DUF163, score 9.7e-130 218494009583 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 218494009584 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 218494009585 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 218494009586 protein binding site [polypeptide binding]; other site 218494009587 1 probable transmembrane helix predicted for SSU1968 by TMHMM2.0 at aa 7-29 218494009588 HMMPfam hit to PF00089, Peptidase S1 and S6, chymotrypsin/Hap, score 6.9e-19 218494009589 ParB-like partition proteins; Region: parB_part; TIGR00180 218494009590 ParB-like nuclease domain; Region: ParBc; cl02129 218494009591 HMMPfam hit to PF02195, ParB-like nuclease, score 7e-35 218494009592 Predicted helix-turn-helix motif with score 1804.000, SD 5.33 at aa 117-138, sequence LTHDEVAQIMGKSRPYISNLLR