-- dump date 20120504_163116 -- class Genbank::misc_feature -- table misc_feature_note -- id note 264199000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 264199000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264199000003 Walker A motif; other site 264199000004 ATP binding site [chemical binding]; other site 264199000005 Walker B motif; other site 264199000006 arginine finger; other site 264199000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 264199000008 DnaA box-binding interface [nucleotide binding]; other site 264199000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 264199000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 264199000011 putative DNA binding surface [nucleotide binding]; other site 264199000012 dimer interface [polypeptide binding]; other site 264199000013 beta-clamp/clamp loader binding surface; other site 264199000014 beta-clamp/translesion DNA polymerase binding surface; other site 264199000015 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 264199000016 GTP-binding protein YchF; Reviewed; Region: PRK09601 264199000017 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 264199000018 G1 box; other site 264199000019 GTP/Mg2+ binding site [chemical binding]; other site 264199000020 Switch I region; other site 264199000021 G2 box; other site 264199000022 Switch II region; other site 264199000023 G3 box; other site 264199000024 G4 box; other site 264199000025 G5 box; other site 264199000026 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 264199000027 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 264199000028 putative active site [active] 264199000029 catalytic residue [active] 264199000030 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 264199000031 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 264199000032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264199000033 ATP binding site [chemical binding]; other site 264199000034 putative Mg++ binding site [ion binding]; other site 264199000035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264199000036 nucleotide binding region [chemical binding]; other site 264199000037 ATP-binding site [chemical binding]; other site 264199000038 TRCF domain; Region: TRCF; cl04088 264199000039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 264199000040 Septum formation initiator; Region: DivIC; cl11433 264199000041 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 264199000042 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 264199000043 Ligand Binding Site [chemical binding]; other site 264199000044 B3/4 domain; Region: B3_4; cl11458 264199000045 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 264199000046 FtsH Extracellular; Region: FtsH_ext; pfam06480 264199000047 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 264199000048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264199000049 Walker A motif; other site 264199000050 ATP binding site [chemical binding]; other site 264199000051 Walker B motif; other site 264199000052 arginine finger; other site 264199000053 Peptidase family M41; Region: Peptidase_M41; pfam01434 264199000054 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 264199000055 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264199000056 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 264199000057 Helix-turn-helix domains; Region: HTH; cl00088 264199000058 putative transposase OrfB; Reviewed; Region: PHA02517 264199000059 Integrase core domain; Region: rve; cl01316 264199000060 rod shape-determining protein MreC; Provisional; Region: PRK13922 264199000061 rod shape-determining protein MreC; Region: MreC; pfam04085 264199000062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 264199000063 Septum formation initiator; Region: DivIC; cl11433 264199000064 NlpC/P60 family; Region: NLPC_P60; cl11438 264199000065 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 264199000066 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 264199000067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 264199000068 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264199000069 aromatic amino acid aminotransferase; Validated; Region: PRK07309 264199000070 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264199000071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264199000072 homodimer interface [polypeptide binding]; other site 264199000073 catalytic residue [active] 264199000074 Recombination protein O N terminal; Region: RecO_N; pfam11967 264199000075 DNA repair protein RecO; Region: reco; TIGR00613 264199000076 Recombination protein O C terminal; Region: RecO_C; pfam02565 264199000077 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 264199000078 Phosphopantetheine attachment site; Region: PP-binding; cl09936 264199000079 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 264199000080 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 264199000081 ATP binding site [chemical binding]; other site 264199000082 active site 264199000083 substrate binding site [chemical binding]; other site 264199000084 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 264199000085 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 264199000086 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 264199000087 dimerization interface [polypeptide binding]; other site 264199000088 ATP binding site [chemical binding]; other site 264199000089 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 264199000090 dimerization interface [polypeptide binding]; other site 264199000091 ATP binding site [chemical binding]; other site 264199000092 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 264199000093 putative active site [active] 264199000094 catalytic triad [active] 264199000095 amidophosphoribosyltransferase; Provisional; Region: PRK07272 264199000096 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 264199000097 active site 264199000098 tetramer interface [polypeptide binding]; other site 264199000099 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 264199000100 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 264199000101 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 264199000102 dimerization interface [polypeptide binding]; other site 264199000103 putative ATP binding site [chemical binding]; other site 264199000104 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 264199000105 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 264199000106 active site 264199000107 substrate binding site [chemical binding]; other site 264199000108 cosubstrate binding site; other site 264199000109 catalytic site [active] 264199000110 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 264199000111 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 264199000112 purine monophosphate binding site [chemical binding]; other site 264199000113 dimer interface [polypeptide binding]; other site 264199000114 putative catalytic residues [active] 264199000115 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 264199000116 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 264199000117 Helix-turn-helix domains; Region: HTH; cl00088 264199000118 putative transposase OrfB; Reviewed; Region: PHA02517 264199000119 Integrase core domain; Region: rve; cl01316 264199000120 putative transposase OrfB; Reviewed; Region: PHA02517 264199000121 NlpC/P60 family; Region: NLPC_P60; cl11438 264199000122 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 264199000123 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 264199000124 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 264199000125 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 264199000126 AIR carboxylase; Region: AIRC; cl00310 264199000127 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 264199000128 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 264199000129 adenylosuccinate lyase; Provisional; Region: PRK07492 264199000130 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 264199000131 tetramer interface [polypeptide binding]; other site 264199000132 active site 264199000133 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 264199000134 Integrase core domain; Region: rve; cl01316 264199000135 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 264199000136 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 264199000137 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 264199000138 active site 264199000139 HIGH motif; other site 264199000140 KMSK motif region; other site 264199000141 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 264199000142 tRNA binding surface [nucleotide binding]; other site 264199000143 anticodon binding site; other site 264199000144 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 264199000145 arginine repressor; Region: argR_whole; TIGR01529 264199000146 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 264199000147 Protein of unknown function (DUF964); Region: DUF964; cl01483 264199000148 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 264199000149 MutS domain I; Region: MutS_I; pfam01624 264199000150 MutS domain II; Region: MutS_II; pfam05188 264199000151 MutS family domain IV; Region: MutS_IV; pfam05190 264199000152 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 264199000153 Walker A/P-loop; other site 264199000154 ATP binding site [chemical binding]; other site 264199000155 Q-loop/lid; other site 264199000156 ABC transporter signature motif; other site 264199000157 Walker B; other site 264199000158 D-loop; other site 264199000159 H-loop/switch region; other site 264199000160 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 264199000161 LytTr DNA-binding domain; Region: LytTR; cl04498 264199000162 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 264199000163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264199000164 ATP binding site [chemical binding]; other site 264199000165 Mg2+ binding site [ion binding]; other site 264199000166 G-X-G motif; other site 264199000167 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 264199000168 ATP binding site [chemical binding]; other site 264199000169 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 264199000170 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 264199000171 RuvA N terminal domain; Region: RuvA_N; pfam01330 264199000172 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 264199000173 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 264199000174 competence damage-inducible protein A; Provisional; Region: PRK00549 264199000175 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 264199000176 putative MPT binding site; other site 264199000177 Competence-damaged protein; Region: CinA; cl00666 264199000178 recombinase A; Provisional; Region: recA; PRK09354 264199000179 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 264199000180 hexamer interface [polypeptide binding]; other site 264199000181 Walker A motif; other site 264199000182 ATP binding site [chemical binding]; other site 264199000183 Walker B motif; other site 264199000184 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 264199000185 ArsC family; Region: ArsC; pfam03960 264199000186 putative catalytic residues [active] 264199000187 thiol/disulfide switch; other site 264199000188 DNA polymerase III PolC; Validated; Region: polC; PRK00448 264199000189 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 264199000190 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 264199000191 generic binding surface II; other site 264199000192 generic binding surface I; other site 264199000193 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 264199000194 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 264199000195 active site 264199000196 substrate binding site [chemical binding]; other site 264199000197 catalytic site [active] 264199000198 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 264199000199 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 264199000200 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 264199000201 Helix-turn-helix domains; Region: HTH; cl00088 264199000202 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 264199000203 putative transposase OrfB; Reviewed; Region: PHA02517 264199000204 Integrase core domain; Region: rve; cl01316 264199000205 putative transposase OrfB; Reviewed; Region: PHA02517 264199000206 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 264199000207 dimer interface [polypeptide binding]; other site 264199000208 catalytic triad [active] 264199000209 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cl00700 264199000210 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 264199000211 rRNA interaction site [nucleotide binding]; other site 264199000212 S8 interaction site; other site 264199000213 putative laminin-1 binding site; other site 264199000214 elongation factor Ts; Provisional; Region: tsf; PRK09377 264199000215 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 264199000216 Elongation factor TS; Region: EF_TS; pfam00889 264199000217 Elongation factor TS; Region: EF_TS; pfam00889 264199000218 Putative small multi-drug export protein; Region: Sm_multidrug_ex; cl01024 264199000219 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 264199000220 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 264199000221 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264199000222 Walker A motif; other site 264199000223 ATP binding site [chemical binding]; other site 264199000224 Walker B motif; other site 264199000225 arginine finger; other site 264199000226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264199000227 Walker A motif; other site 264199000228 ATP binding site [chemical binding]; other site 264199000229 Walker B motif; other site 264199000230 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 264199000231 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 264199000232 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 264199000233 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 264199000234 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 264199000235 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264199000236 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 264199000237 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 264199000238 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 264199000239 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 264199000240 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 264199000241 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 264199000242 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 264199000243 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 264199000244 putative nucleic acid binding region [nucleotide binding]; other site 264199000245 G-X-X-G motif; other site 264199000246 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 264199000247 RNA binding site [nucleotide binding]; other site 264199000248 domain interface; other site 264199000249 serine acetyltransferase; Region: PLN02739 264199000250 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 264199000251 trimer interface [polypeptide binding]; other site 264199000252 active site 264199000253 substrate binding site [chemical binding]; other site 264199000254 CoA binding site [chemical binding]; other site 264199000255 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 264199000256 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 264199000257 active site 264199000258 HIGH motif; other site 264199000259 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 264199000260 KMSKS motif; other site 264199000261 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 264199000262 tRNA binding surface [nucleotide binding]; other site 264199000263 anticodon binding site; other site 264199000264 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 264199000265 active site 264199000266 metal binding site [ion binding]; metal-binding site 264199000267 dimerization interface [polypeptide binding]; other site 264199000268 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 264199000269 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 264199000270 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 264199000271 YacP-like NYN domain; Region: NYN_YacP; cl01491 264199000272 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 264199000273 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199000274 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 264199000275 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 264199000276 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 264199000277 23S rRNA interface [nucleotide binding]; other site 264199000278 L3 interface [polypeptide binding]; other site 264199000279 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 264199000280 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 264199000281 DNA binding site [nucleotide binding] 264199000282 active site 264199000283 Int/Topo IB signature motif; other site 264199000284 catalytic residues [active] 264199000285 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 264199000286 Catalytic site [active] 264199000287 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 264199000288 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 264199000289 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 264199000290 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 264199000291 active site 264199000292 zinc binding site [ion binding]; other site 264199000293 H+ Antiporter protein; Region: 2A0121; TIGR00900 264199000294 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 264199000295 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264199000296 DNA binding site [nucleotide binding] 264199000297 Int/Topo IB signature motif; other site 264199000298 active site 264199000299 NlpC/P60 family; Region: NLPC_P60; cl11438 264199000300 Integrase core domain; Region: rve; cl01316 264199000301 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 264199000302 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 264199000303 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 264199000304 putative active site [active] 264199000305 putative metal binding site [ion binding]; other site 264199000306 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 264199000307 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 264199000308 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264199000309 catalytic core [active] 264199000310 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 264199000311 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 264199000312 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 264199000313 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 264199000314 Helix-turn-helix domains; Region: HTH; cl00088 264199000315 HrcA protein C terminal domain; Region: HrcA; pfam01628 264199000316 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 264199000317 dimer interface [polypeptide binding]; other site 264199000318 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 264199000319 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 264199000320 chaperone protein DnaJ; Provisional; Region: PRK14276 264199000321 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 264199000322 HSP70 interaction site [polypeptide binding]; other site 264199000323 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 264199000324 substrate binding site [polypeptide binding]; other site 264199000325 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 264199000326 Zn binding sites [ion binding]; other site 264199000327 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 264199000328 dimer interface [polypeptide binding]; other site 264199000329 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 264199000330 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 264199000331 dimerization interface 3.5A [polypeptide binding]; other site 264199000332 active site 264199000333 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 264199000334 substrate binding site [chemical binding]; other site 264199000335 dimer interface [polypeptide binding]; other site 264199000336 ATP binding site [chemical binding]; other site 264199000337 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 264199000338 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 264199000339 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 264199000340 peptide binding site [polypeptide binding]; other site 264199000341 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 264199000342 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264199000343 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 264199000344 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 264199000345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264199000346 S-adenosylmethionine binding site [chemical binding]; other site 264199000347 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 264199000348 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264199000349 Mechanosensitive ion channel; Region: MS_channel; pfam00924 264199000350 trigger factor; Provisional; Region: tig; PRK01490 264199000351 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 264199000352 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 264199000353 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 264199000354 CTP synthetase; Validated; Region: pyrG; PRK05380 264199000355 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 264199000356 Catalytic site [active] 264199000357 active site 264199000358 UTP binding site [chemical binding]; other site 264199000359 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 264199000360 active site 264199000361 putative oxyanion hole; other site 264199000362 catalytic triad [active] 264199000363 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 264199000364 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 264199000365 nudix motif; other site 264199000366 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 264199000367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264199000368 S-adenosylmethionine binding site [chemical binding]; other site 264199000369 RNA methyltransferase, RsmE family; Region: TIGR00046 264199000370 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 264199000371 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK11907 264199000372 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 264199000373 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 264199000374 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 264199000375 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 264199000376 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase precursor protein; Reviewed; Region: PRK11907 264199000377 Gram positive anchor; Region: Gram_pos_anchor; cl15427 264199000378 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 264199000379 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 264199000380 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 264199000381 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 264199000382 synthetase active site [active] 264199000383 NTP binding site [chemical binding]; other site 264199000384 metal binding site [ion binding]; metal-binding site 264199000385 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 264199000386 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 264199000387 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 264199000388 putative active site [active] 264199000389 dimerization interface [polypeptide binding]; other site 264199000390 putative tRNAtyr binding site [nucleotide binding]; other site 264199000391 Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199 264199000392 Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199 264199000393 threonine dehydratase; Validated; Region: PRK08639 264199000394 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 264199000395 tetramer interface [polypeptide binding]; other site 264199000396 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264199000397 catalytic residue [active] 264199000398 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 264199000399 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 264199000400 active site 264199000401 catalytic residues [active] 264199000402 metal binding site [ion binding]; metal-binding site 264199000403 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 264199000404 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 264199000405 ligand binding site [chemical binding]; other site 264199000406 flexible hinge region; other site 264199000407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264199000408 Major Facilitator Superfamily; Region: MFS_1; pfam07690 264199000409 putative substrate translocation pore; other site 264199000410 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 264199000411 16S/18S rRNA binding site [nucleotide binding]; other site 264199000412 S13e-L30e interaction site [polypeptide binding]; other site 264199000413 25S rRNA binding site [nucleotide binding]; other site 264199000414 VanZ like family; Region: VanZ; cl01971 264199000415 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264199000416 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199000417 Walker A/P-loop; other site 264199000418 ATP binding site [chemical binding]; other site 264199000419 Q-loop/lid; other site 264199000420 ABC transporter signature motif; other site 264199000421 Walker B; other site 264199000422 D-loop; other site 264199000423 H-loop/switch region; other site 264199000424 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264199000425 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264199000426 substrate binding pocket [chemical binding]; other site 264199000427 membrane-bound complex binding site; other site 264199000428 hinge residues; other site 264199000429 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264199000430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264199000431 dimer interface [polypeptide binding]; other site 264199000432 conserved gate region; other site 264199000433 putative PBP binding loops; other site 264199000434 ABC-ATPase subunit interface; other site 264199000435 Bacitracin resistance protein BacA; Region: BacA; cl00858 264199000436 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 264199000437 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 264199000438 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 264199000439 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 264199000440 Mg++ binding site [ion binding]; other site 264199000441 putative catalytic motif [active] 264199000442 substrate binding site [chemical binding]; other site 264199000443 FeS assembly ATPase SufC; Region: sufC; TIGR01978 264199000444 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 264199000445 Walker A/P-loop; other site 264199000446 ATP binding site [chemical binding]; other site 264199000447 Q-loop/lid; other site 264199000448 ABC transporter signature motif; other site 264199000449 Walker B; other site 264199000450 D-loop; other site 264199000451 H-loop/switch region; other site 264199000452 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 264199000453 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 264199000454 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 264199000455 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 264199000456 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264199000457 catalytic residue [active] 264199000458 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 264199000459 trimerization site [polypeptide binding]; other site 264199000460 active site 264199000461 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 264199000462 FeS assembly protein SufB; Region: sufB; TIGR01980 264199000463 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 264199000464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 264199000465 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 264199000466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264199000467 conserved gate region; other site 264199000468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264199000469 dimer interface [polypeptide binding]; other site 264199000470 ABC-ATPase subunit interface; other site 264199000471 putative PBP binding loops; other site 264199000472 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199000473 Walker A/P-loop; other site 264199000474 ATP binding site [chemical binding]; other site 264199000475 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199000476 Q-loop/lid; other site 264199000477 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 264199000478 ABC transporter signature motif; other site 264199000479 Walker B; other site 264199000480 D-loop; other site 264199000481 H-loop/switch region; other site 264199000482 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264199000483 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 264199000484 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 264199000485 Walker A/P-loop; other site 264199000486 ATP binding site [chemical binding]; other site 264199000487 Q-loop/lid; other site 264199000488 ABC transporter signature motif; other site 264199000489 Walker B; other site 264199000490 D-loop; other site 264199000491 H-loop/switch region; other site 264199000492 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264199000493 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 264199000494 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 264199000495 dimerization interface [polypeptide binding]; other site 264199000496 domain crossover interface; other site 264199000497 redox-dependent activation switch; other site 264199000498 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 264199000499 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 264199000500 FMN binding site [chemical binding]; other site 264199000501 active site 264199000502 catalytic residues [active] 264199000503 substrate binding site [chemical binding]; other site 264199000504 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 264199000505 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264199000506 active site 264199000507 ATP binding site [chemical binding]; other site 264199000508 substrate binding site [chemical binding]; other site 264199000509 activation loop (A-loop); other site 264199000510 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 264199000511 active site 264199000512 zinc binding site [ion binding]; other site 264199000513 H+ Antiporter protein; Region: 2A0121; TIGR00900 264199000514 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 264199000515 putative DNA binding site [nucleotide binding]; other site 264199000516 putative Zn2+ binding site [ion binding]; other site 264199000517 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 264199000518 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 264199000519 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 264199000520 ABC-ATPase subunit interface; other site 264199000521 dimer interface [polypeptide binding]; other site 264199000522 putative PBP binding regions; other site 264199000523 Membrane transport protein; Region: Mem_trans; cl09117 264199000524 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 264199000525 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 264199000526 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 264199000527 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 264199000528 active site turn [active] 264199000529 phosphorylation site [posttranslational modification] 264199000530 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 264199000531 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 264199000532 HPr interaction site; other site 264199000533 glycerol kinase (GK) interaction site [polypeptide binding]; other site 264199000534 active site 264199000535 phosphorylation site [posttranslational modification] 264199000536 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 264199000537 putative catalytic site [active] 264199000538 putative metal binding site [ion binding]; other site 264199000539 putative phosphate binding site [ion binding]; other site 264199000540 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 264199000541 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 264199000542 active site 264199000543 dimer interface [polypeptide binding]; other site 264199000544 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 264199000545 dimer interface [polypeptide binding]; other site 264199000546 active site 264199000547 Domain of unknown function DUF28; Region: DUF28; cl00361 264199000548 Preprotein translocase subunit; Region: YajC; cl00806 264199000549 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 264199000550 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 264199000551 catalytic residue [active] 264199000552 putative FPP diphosphate binding site; other site 264199000553 putative FPP binding hydrophobic cleft; other site 264199000554 dimer interface [polypeptide binding]; other site 264199000555 putative IPP diphosphate binding site; other site 264199000556 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 264199000557 RIP metalloprotease RseP; Region: TIGR00054 264199000558 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 264199000559 active site 264199000560 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 264199000561 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 264199000562 protein binding site [polypeptide binding]; other site 264199000563 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 264199000564 putative substrate binding region [chemical binding]; other site 264199000565 prolyl-tRNA synthetase; Provisional; Region: PRK09194 264199000566 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 264199000567 dimer interface [polypeptide binding]; other site 264199000568 motif 1; other site 264199000569 active site 264199000570 motif 2; other site 264199000571 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 264199000572 putative deacylase active site [active] 264199000573 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 264199000574 active site 264199000575 motif 3; other site 264199000576 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 264199000577 anticodon binding site; other site 264199000578 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 264199000579 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 264199000580 zinc binding site [ion binding]; other site 264199000581 putative ligand binding site [chemical binding]; other site 264199000582 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 264199000583 TM-ABC transporter signature motif; other site 264199000584 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 264199000585 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199000586 Walker A/P-loop; other site 264199000587 ATP binding site [chemical binding]; other site 264199000588 Q-loop/lid; other site 264199000589 ABC transporter signature motif; other site 264199000590 Walker B; other site 264199000591 D-loop; other site 264199000592 H-loop/switch region; other site 264199000593 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 264199000594 oligomerisation interface [polypeptide binding]; other site 264199000595 mobile loop; other site 264199000596 roof hairpin; other site 264199000597 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 264199000598 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 264199000599 ring oligomerisation interface [polypeptide binding]; other site 264199000600 ATP/Mg binding site [chemical binding]; other site 264199000601 stacking interactions; other site 264199000602 hinge regions; other site 264199000603 Helix-turn-helix domains; Region: HTH; cl00088 264199000604 putative transposase OrfB; Reviewed; Region: PHA02517 264199000605 putative transposase OrfB; Reviewed; Region: PHA02517 264199000606 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 264199000607 TM2 domain; Region: TM2; cl00984 264199000608 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 264199000609 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 264199000610 active site 264199000611 Transglycosylase; Region: Transgly; cl07896 264199000612 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 264199000613 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264199000614 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 264199000615 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 264199000616 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 264199000617 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 264199000618 putative homodimer interface [polypeptide binding]; other site 264199000619 KOW motif; Region: KOW; cl00354 264199000620 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 264199000621 active site 264199000622 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 264199000623 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264199000624 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 264199000625 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 264199000626 Helix-turn-helix domains; Region: HTH; cl00088 264199000627 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 264199000628 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 264199000629 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 264199000630 HIGH motif; other site 264199000631 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264199000632 active site 264199000633 KMSKS motif; other site 264199000634 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 264199000635 tRNA binding surface [nucleotide binding]; other site 264199000636 Helix-turn-helix domains; Region: HTH; cl00088 264199000637 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 264199000638 Integrase core domain; Region: rve; cl01316 264199000639 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 264199000640 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 264199000641 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264199000642 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 264199000643 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 264199000644 active site 264199000645 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 264199000646 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 264199000647 homodimer interface [polypeptide binding]; other site 264199000648 NAD binding pocket [chemical binding]; other site 264199000649 ATP binding pocket [chemical binding]; other site 264199000650 Mg binding site [ion binding]; other site 264199000651 active-site loop [active] 264199000652 Protein of unknown function (DUF805); Region: DUF805; cl01224 264199000653 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 264199000654 trimer interface [polypeptide binding]; other site 264199000655 active site 264199000656 G bulge; other site 264199000657 Transglycosylase; Region: Transgly; cl07896 264199000658 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 264199000659 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264199000660 Recombination protein U; Region: RecU; cl01314 264199000661 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 264199000662 cell division protein GpsB; Provisional; Region: PRK14127 264199000663 DivIVA domain; Region: DivI1A_domain; TIGR03544 264199000664 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 264199000665 THUMP domain; Region: THUMP; cl12076 264199000666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 264199000667 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 264199000668 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 264199000669 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264199000670 ATP binding site [chemical binding]; other site 264199000671 putative Mg++ binding site [ion binding]; other site 264199000672 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264199000673 nucleotide binding region [chemical binding]; other site 264199000674 ATP-binding site [chemical binding]; other site 264199000675 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 264199000676 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264199000677 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 264199000678 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264199000679 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264199000680 Coenzyme A binding pocket [chemical binding]; other site 264199000681 YceG-like family; Region: YceG; pfam02618 264199000682 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 264199000683 dimerization interface [polypeptide binding]; other site 264199000684 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 264199000685 domain; Region: GreA_GreB_N; pfam03449 264199000686 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 264199000687 Integrase core domain; Region: rve; cl01316 264199000688 OxaA-like protein precursor; Provisional; Region: PRK02463 264199000689 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 264199000690 Acylphosphatase; Region: Acylphosphatase; cl00551 264199000691 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 264199000692 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 264199000693 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 264199000694 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 264199000695 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 264199000696 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 264199000697 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 264199000698 active site 264199000699 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264199000700 substrate binding site [chemical binding]; other site 264199000701 catalytic residues [active] 264199000702 dimer interface [polypeptide binding]; other site 264199000703 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 264199000704 Uncharacterised protein family (UPF0154); Region: UPF0154; cl01536 264199000705 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 264199000706 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 264199000707 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 264199000708 active site 264199000709 dimerization interface [polypeptide binding]; other site 264199000710 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264199000711 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 264199000712 active site 264199000713 metal binding site [ion binding]; metal-binding site 264199000714 homotetramer interface [polypeptide binding]; other site 264199000715 FOG: CBS domain [General function prediction only]; Region: COG0517 264199000716 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 264199000717 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 264199000718 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264199000719 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 264199000720 DNA binding site [nucleotide binding] 264199000721 Int/Topo IB signature motif; other site 264199000722 active site 264199000723 catalytic residues [active] 264199000724 ScpA/B protein; Region: ScpA_ScpB; cl00598 264199000725 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 264199000726 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 264199000727 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264199000728 RNA binding surface [nucleotide binding]; other site 264199000729 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 264199000730 active site 264199000731 Domain of unknown function DUF37; Region: DUF37; cl00506 264199000732 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 264199000733 Cation transport protein; Region: TrkH; cl10514 264199000734 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 264199000735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199000736 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 264199000737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199000738 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 264199000739 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 264199000740 Integrase core domain; Region: rve; cl01316 264199000741 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 264199000742 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 264199000743 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 264199000744 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 264199000745 active site 264199000746 Helix-turn-helix domains; Region: HTH; cl00088 264199000747 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 264199000748 putative active site [active] 264199000749 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 264199000750 putative active site [active] 264199000751 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 264199000752 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 264199000753 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 264199000754 Walker A/P-loop; other site 264199000755 ATP binding site [chemical binding]; other site 264199000756 Q-loop/lid; other site 264199000757 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199000758 ABC transporter signature motif; other site 264199000759 Walker B; other site 264199000760 D-loop; other site 264199000761 H-loop/switch region; other site 264199000762 Protein of unknown function (DUF805); Region: DUF805; cl01224 264199000763 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 264199000764 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 264199000765 alpha-gamma subunit interface [polypeptide binding]; other site 264199000766 beta-gamma subunit interface [polypeptide binding]; other site 264199000767 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 264199000768 gamma-beta subunit interface [polypeptide binding]; other site 264199000769 alpha-beta subunit interface [polypeptide binding]; other site 264199000770 urease subunit alpha; Reviewed; Region: ureC; PRK13207 264199000771 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 264199000772 subunit interactions [polypeptide binding]; other site 264199000773 active site 264199000774 flap region; other site 264199000775 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 264199000776 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 264199000777 dimer interface [polypeptide binding]; other site 264199000778 catalytic residues [active] 264199000779 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 264199000780 UreF; Region: UreF; pfam01730 264199000781 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199000782 UreD urease accessory protein; Region: UreD; cl00530 264199000783 cobalt transport protein CbiM; Provisional; Region: PRK07331 264199000784 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 264199000785 Cobalt transport protein; Region: CbiQ; cl00463 264199000786 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 264199000787 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 264199000788 Walker A/P-loop; other site 264199000789 ATP binding site [chemical binding]; other site 264199000790 Q-loop/lid; other site 264199000791 ABC transporter signature motif; other site 264199000792 Walker B; other site 264199000793 D-loop; other site 264199000794 H-loop/switch region; other site 264199000795 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264199000796 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264199000797 substrate binding pocket [chemical binding]; other site 264199000798 membrane-bound complex binding site; other site 264199000799 hinge residues; other site 264199000800 AMP-binding enzyme; Region: AMP-binding; pfam00501 264199000801 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 264199000802 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 264199000803 nudix motif; other site 264199000804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199000805 NAD+ binding site [chemical binding]; other site 264199000806 oligomerization interface [polypeptide binding]; other site 264199000807 H+ Antiporter protein; Region: 2A0121; TIGR00900 264199000808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264199000809 putative substrate translocation pore; other site 264199000810 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 264199000811 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264199000812 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264199000813 substrate binding pocket [chemical binding]; other site 264199000814 membrane-bound complex binding site; other site 264199000815 hinge residues; other site 264199000816 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 264199000817 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 264199000818 metal binding site [ion binding]; metal-binding site 264199000819 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 264199000820 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 264199000821 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 264199000822 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 264199000823 Walker A/P-loop; other site 264199000824 ATP binding site [chemical binding]; other site 264199000825 Q-loop/lid; other site 264199000826 ABC transporter signature motif; other site 264199000827 Walker B; other site 264199000828 D-loop; other site 264199000829 H-loop/switch region; other site 264199000830 NIL domain; Region: NIL; cl09633 264199000831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 264199000832 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 264199000833 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 264199000834 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 264199000835 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 264199000836 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 264199000837 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199000838 Walker A/P-loop; other site 264199000839 ATP binding site [chemical binding]; other site 264199000840 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 264199000841 Q-loop/lid; other site 264199000842 ABC transporter signature motif; other site 264199000843 Walker B; other site 264199000844 D-loop; other site 264199000845 H-loop/switch region; other site 264199000846 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 264199000847 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 264199000848 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 264199000849 Walker A/P-loop; other site 264199000850 ATP binding site [chemical binding]; other site 264199000851 Q-loop/lid; other site 264199000852 ABC transporter signature motif; other site 264199000853 Walker B; other site 264199000854 D-loop; other site 264199000855 H-loop/switch region; other site 264199000856 Cobalt transport protein; Region: CbiQ; cl00463 264199000857 transketolase; Reviewed; Region: PRK05899 264199000858 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 264199000859 TPP-binding site [chemical binding]; other site 264199000860 dimer interface [polypeptide binding]; other site 264199000861 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 264199000862 PYR/PP interface [polypeptide binding]; other site 264199000863 dimer interface [polypeptide binding]; other site 264199000864 TPP binding site [chemical binding]; other site 264199000865 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264199000866 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 264199000867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199000868 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 264199000869 Cation transport protein; Region: TrkH; cl10514 264199000870 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 264199000871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264199000872 S-adenosylmethionine binding site [chemical binding]; other site 264199000873 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 264199000874 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264199000875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264199000876 active site 264199000877 phosphorylation site [posttranslational modification] 264199000878 intermolecular recognition site; other site 264199000879 dimerization interface [polypeptide binding]; other site 264199000880 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264199000881 DNA binding site [nucleotide binding] 264199000882 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 264199000883 dimerization interface [polypeptide binding]; other site 264199000884 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264199000885 dimer interface [polypeptide binding]; other site 264199000886 phosphorylation site [posttranslational modification] 264199000887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264199000888 ATP binding site [chemical binding]; other site 264199000889 Mg2+ binding site [ion binding]; other site 264199000890 G-X-G motif; other site 264199000891 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 264199000892 ATP cone domain; Region: ATP-cone; pfam03477 264199000893 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 264199000894 primosomal protein DnaI; Reviewed; Region: PRK08939 264199000895 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 264199000896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264199000897 Walker A motif; other site 264199000898 ATP binding site [chemical binding]; other site 264199000899 Walker B motif; other site 264199000900 arginine finger; other site 264199000901 GTP-binding protein Der; Reviewed; Region: PRK00093 264199000902 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA1; cd01894 264199000903 G1 box; other site 264199000904 GTP/Mg2+ binding site [chemical binding]; other site 264199000905 Switch I region; other site 264199000906 G2 box; other site 264199000907 Switch II region; other site 264199000908 G3 box; other site 264199000909 G4 box; other site 264199000910 G5 box; other site 264199000911 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA2; cd01895 264199000912 G1 box; other site 264199000913 GTP/Mg2+ binding site [chemical binding]; other site 264199000914 Switch I region; other site 264199000915 G2 box; other site 264199000916 G3 box; other site 264199000917 Switch II region; other site 264199000918 G4 box; other site 264199000919 G5 box; other site 264199000920 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264199000921 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 264199000922 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199000923 Walker A/P-loop; other site 264199000924 ATP binding site [chemical binding]; other site 264199000925 Q-loop/lid; other site 264199000926 ABC transporter signature motif; other site 264199000927 Walker B; other site 264199000928 D-loop; other site 264199000929 H-loop/switch region; other site 264199000930 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264199000931 MULE transposase domain; Region: MULE; pfam10551 264199000932 seryl-tRNA synthetase; Provisional; Region: PRK05431 264199000933 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 264199000934 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 264199000935 dimer interface [polypeptide binding]; other site 264199000936 active site 264199000937 motif 1; other site 264199000938 motif 2; other site 264199000939 motif 3; other site 264199000940 Domain of unknown function (DUF956); Region: DUF956; cl01917 264199000941 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 264199000942 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 264199000943 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 264199000944 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 264199000945 active pocket/dimerization site; other site 264199000946 active site 264199000947 phosphorylation site [posttranslational modification] 264199000948 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 264199000949 active site 264199000950 phosphorylation site [posttranslational modification] 264199000951 Putative cyclase; Region: Cyclase; cl00814 264199000952 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 264199000953 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264199000954 active site 264199000955 motif I; other site 264199000956 motif II; other site 264199000957 Permease family; Region: Xan_ur_permease; cl00967 264199000958 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 264199000959 putative acetyltransferase YhhY; Provisional; Region: PRK10140 264199000960 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264199000961 Coenzyme A binding pocket [chemical binding]; other site 264199000962 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 264199000963 ribosome maturation protein RimP; Reviewed; Region: PRK00092 264199000964 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 264199000965 Sm1 motif; other site 264199000966 predicted subunit interaction site [polypeptide binding]; other site 264199000967 RNA binding pocket [nucleotide binding]; other site 264199000968 Sm2 motif; other site 264199000969 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 264199000970 NusA N-terminal domain; Region: NusA_N; pfam08529 264199000971 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 264199000972 RNA binding site [nucleotide binding]; other site 264199000973 homodimer interface [polypeptide binding]; other site 264199000974 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 264199000975 G-X-X-G motif; other site 264199000976 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 264199000977 putative RNA binding cleft [nucleotide binding]; other site 264199000978 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 264199000979 translation initiation factor IF-2; Validated; Region: infB; PRK05306 264199000980 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 264199000981 translation initiation factor IF-2; Region: IF-2; TIGR00487 264199000982 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 264199000983 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases; Region: IF2_eIF5B; cd01887 264199000984 G1 box; other site 264199000985 putative GEF interaction site [polypeptide binding]; other site 264199000986 GTP/Mg2+ binding site [chemical binding]; other site 264199000987 Switch I region; other site 264199000988 G2 box; other site 264199000989 G3 box; other site 264199000990 Switch II region; other site 264199000991 G4 box; other site 264199000992 G5 box; other site 264199000993 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 264199000994 Translation-initiation factor 2; Region: IF-2; pfam11987 264199000995 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 264199000996 Ribosome-binding factor A; Region: RBFA; cl00542 264199000997 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 264199000998 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 264199000999 FemAB family; Region: FemAB; cl11444 264199001000 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 264199001001 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264199001002 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 264199001003 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264199001004 MatE; Region: MatE; cl10513 264199001005 stage V sporulation protein B; Region: spore_V_B; TIGR02900 264199001006 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 264199001007 cystathionine gamma-synthase; Reviewed; Region: PRK07269 264199001008 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 264199001009 homodimer interface [polypeptide binding]; other site 264199001010 substrate-cofactor binding pocket; other site 264199001011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264199001012 catalytic residue [active] 264199001013 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 264199001014 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264199001015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264199001016 homodimer interface [polypeptide binding]; other site 264199001017 catalytic residue [active] 264199001018 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 264199001019 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 264199001020 oligomer interface [polypeptide binding]; other site 264199001021 active site residues [active] 264199001022 Protein of unknown function (DUF964); Region: DUF964; cl01483 264199001023 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 264199001024 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 264199001025 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 264199001026 putative ligand binding site [chemical binding]; other site 264199001027 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 264199001028 TM-ABC transporter signature motif; other site 264199001029 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 264199001030 TM-ABC transporter signature motif; other site 264199001031 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 264199001032 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 264199001033 Walker A/P-loop; other site 264199001034 ATP binding site [chemical binding]; other site 264199001035 Q-loop/lid; other site 264199001036 ABC transporter signature motif; other site 264199001037 Walker B; other site 264199001038 D-loop; other site 264199001039 H-loop/switch region; other site 264199001040 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 264199001041 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 264199001042 Walker A/P-loop; other site 264199001043 ATP binding site [chemical binding]; other site 264199001044 Q-loop/lid; other site 264199001045 ABC transporter signature motif; other site 264199001046 Walker B; other site 264199001047 D-loop; other site 264199001048 H-loop/switch region; other site 264199001049 FOG: CBS domain [General function prediction only]; Region: COG0517 264199001050 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 264199001051 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 264199001052 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 264199001053 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 264199001054 dimer interface [polypeptide binding]; other site 264199001055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264199001056 catalytic residue [active] 264199001057 Uncharacterized conserved protein [Function unknown]; Region: COG1739 264199001058 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 264199001059 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 264199001060 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 264199001061 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264199001062 ATP binding site [chemical binding]; other site 264199001063 putative Mg++ binding site [ion binding]; other site 264199001064 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264199001065 nucleotide binding region [chemical binding]; other site 264199001066 ATP-binding site [chemical binding]; other site 264199001067 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 264199001068 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 264199001069 30S subunit binding site; other site 264199001070 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 264199001071 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 264199001072 DHHA2 domain; Region: DHHA2; pfam02833 264199001073 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 264199001074 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 264199001075 Protein of unknown function (DUF402); Region: DUF402; cl00979 264199001076 RecX family; Region: RecX; cl00936 264199001077 TRAM domain; Region: TRAM; cl01282 264199001078 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 264199001079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 264199001080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264199001081 S-adenosylmethionine binding site [chemical binding]; other site 264199001082 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 264199001083 dimer interface [polypeptide binding]; other site 264199001084 active site 264199001085 aspartate kinase; Reviewed; Region: PRK09034 264199001086 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 264199001087 putative catalytic residues [active] 264199001088 putative nucleotide binding site [chemical binding]; other site 264199001089 putative aspartate binding site [chemical binding]; other site 264199001090 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 264199001091 allosteric regulatory residue; other site 264199001092 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 264199001093 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 264199001094 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264199001095 motif II; other site 264199001096 enoyl-CoA hydratase; Provisional; Region: PRK07260 264199001097 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 264199001098 substrate binding site [chemical binding]; other site 264199001099 oxyanion hole (OAH) forming residues; other site 264199001100 trimer interface [polypeptide binding]; other site 264199001101 Helix-turn-helix domains; Region: HTH; cl00088 264199001102 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 264199001103 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 264199001104 dimer interface [polypeptide binding]; other site 264199001105 active site 264199001106 CoA binding pocket [chemical binding]; other site 264199001107 Phosphopantetheine attachment site; Region: PP-binding; cl09936 264199001108 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 264199001109 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 264199001110 FMN binding site [chemical binding]; other site 264199001111 substrate binding site [chemical binding]; other site 264199001112 putative catalytic residue [active] 264199001113 Acyl transferase domain; Region: Acyl_transf_1; cl08282 264199001114 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 264199001115 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 264199001116 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199001117 NAD(P) binding site [chemical binding]; other site 264199001118 active site 264199001119 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 264199001120 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 264199001121 dimer interface [polypeptide binding]; other site 264199001122 active site 264199001123 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 264199001124 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 264199001125 carboxyltransferase (CT) interaction site; other site 264199001126 biotinylation site [posttranslational modification]; other site 264199001127 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 264199001128 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 264199001129 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264199001130 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 264199001131 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 264199001132 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 264199001133 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 264199001134 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 264199001135 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 264199001136 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 264199001137 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 264199001138 Integrase core domain; Region: rve; cl01316 264199001139 hypothetical protein; Provisional; Region: PRK00106 264199001140 THO complex subunit HPR1; Region: HRP1; pfam09433 264199001141 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 264199001142 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264199001143 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 264199001144 Helix-turn-helix domains; Region: HTH; cl00088 264199001145 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 264199001146 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 264199001147 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 264199001148 putative substrate binding site [chemical binding]; other site 264199001149 putative ATP binding site [chemical binding]; other site 264199001150 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 264199001151 active site 264199001152 phosphorylation site [posttranslational modification] 264199001153 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 264199001154 P-loop; other site 264199001155 active site 264199001156 phosphorylation site [posttranslational modification] 264199001157 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 264199001158 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 264199001159 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 264199001160 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 264199001161 glutathione reductase; Validated; Region: PRK06116 264199001162 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199001163 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199001164 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264199001165 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 264199001166 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 264199001167 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264199001168 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264199001169 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 264199001170 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264199001171 catalytic residue [active] 264199001172 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 264199001173 THUMP domain; Region: THUMP; cl12076 264199001174 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 264199001175 Ligand Binding Site [chemical binding]; other site 264199001176 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 264199001177 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 264199001178 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 264199001179 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 264199001180 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 264199001181 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 264199001182 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 264199001183 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 264199001184 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 264199001185 Protein of unknown function (DUF1149); Region: DUF1149; cl11551 264199001186 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 264199001187 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 264199001188 dihydrodipicolinate reductase; Provisional; Region: PRK00048 264199001189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199001190 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 264199001191 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 264199001192 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 264199001193 active site 264199001194 NTP binding site [chemical binding]; other site 264199001195 metal binding triad [ion binding]; metal-binding site 264199001196 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 264199001197 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 264199001198 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199001199 Walker A/P-loop; other site 264199001200 ATP binding site [chemical binding]; other site 264199001201 Q-loop/lid; other site 264199001202 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 264199001203 ABC transporter; Region: ABC_tran_2; pfam12848 264199001204 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 264199001205 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 264199001206 nudix motif; other site 264199001207 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 264199001208 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 264199001209 active site 264199001210 (T/H)XGH motif; other site 264199001211 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; cl01238 264199001212 glutamate dehydrogenase; Provisional; Region: PRK09414 264199001213 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 264199001214 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 264199001215 NAD(P) binding site [chemical binding]; other site 264199001216 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 264199001217 active site 264199001218 catalytic residues [active] 264199001219 metal binding site [ion binding]; metal-binding site 264199001220 Helix-turn-helix domains; Region: HTH; cl00088 264199001221 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264199001222 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 264199001223 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199001224 Walker A/P-loop; other site 264199001225 ATP binding site [chemical binding]; other site 264199001226 Q-loop/lid; other site 264199001227 ABC transporter signature motif; other site 264199001228 Walker B; other site 264199001229 D-loop; other site 264199001230 H-loop/switch region; other site 264199001231 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264199001232 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 264199001233 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 264199001234 Walker A/P-loop; other site 264199001235 ATP binding site [chemical binding]; other site 264199001236 Q-loop/lid; other site 264199001237 ABC transporter signature motif; other site 264199001238 Walker B; other site 264199001239 D-loop; other site 264199001240 H-loop/switch region; other site 264199001241 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264199001242 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264199001243 dimer interface [polypeptide binding]; other site 264199001244 phosphorylation site [posttranslational modification] 264199001245 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 264199001246 putative nucleotide binding site [chemical binding]; other site 264199001247 uridine monophosphate binding site [chemical binding]; other site 264199001248 homohexameric interface [polypeptide binding]; other site 264199001249 ribosome recycling factor; Reviewed; Region: frr; PRK00083 264199001250 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 264199001251 hinge region; other site 264199001252 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 264199001253 Protein of unknown function (DUF1250); Region: DUF1250; cl11485 264199001254 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 264199001255 putative peptidoglycan binding site; other site 264199001256 NlpC/P60 family; Region: NLPC_P60; cl11438 264199001257 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 264199001258 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199001259 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 264199001260 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 264199001261 active site 264199001262 HIGH motif; other site 264199001263 KMSKS motif; other site 264199001264 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 264199001265 tRNA binding surface [nucleotide binding]; other site 264199001266 anticodon binding site; other site 264199001267 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 264199001268 dimer interface [polypeptide binding]; other site 264199001269 putative tRNA-binding site [nucleotide binding]; other site 264199001270 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264199001271 Helix-turn-helix domains; Region: HTH; cl00088 264199001272 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264199001273 dimerization interface [polypeptide binding]; other site 264199001274 Competence protein CoiA-like family; Region: CoiA; cl11541 264199001275 oligoendopeptidase F; Region: pepF; TIGR00181 264199001276 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 264199001277 active site 264199001278 Zn binding site [ion binding]; other site 264199001279 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 264199001280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264199001281 S-adenosylmethionine binding site [chemical binding]; other site 264199001282 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 264199001283 SurA N-terminal domain; Region: SurA_N; pfam09312 264199001284 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 264199001285 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 264199001286 motif 1; other site 264199001287 active site 264199001288 motif 2; other site 264199001289 motif 3; other site 264199001290 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 264199001291 DHHA1 domain; Region: DHHA1; pfam02272 264199001292 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 264199001293 Bacterial SH3 domain; Region: SH3_3; cl02551 264199001294 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 264199001295 Bacterial SH3 domain; Region: SH3_3; cl02551 264199001296 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 264199001297 Bacterial SH3 domain; Region: SH3_3; cl02551 264199001298 Bacterial SH3 domain; Region: SH3_3; cl02551 264199001299 Predicted amidohydrolase [General function prediction only]; Region: COG0388 264199001300 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 264199001301 putative active site [active] 264199001302 catalytic triad [active] 264199001303 putative dimer interface [polypeptide binding]; other site 264199001304 transaminase; Reviewed; Region: PRK08068 264199001305 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264199001306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264199001307 homodimer interface [polypeptide binding]; other site 264199001308 catalytic residue [active] 264199001309 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 264199001310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199001311 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 264199001312 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 264199001313 heterotetramer interface [polypeptide binding]; other site 264199001314 active site pocket [active] 264199001315 cleavage site 264199001316 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 264199001317 nucleotide binding site [chemical binding]; other site 264199001318 N-acetyl-L-glutamate binding site [chemical binding]; other site 264199001319 acetylornithine aminotransferase; Provisional; Region: PRK04260 264199001320 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 264199001321 inhibitor-cofactor binding pocket; inhibition site 264199001322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264199001323 catalytic residue [active] 264199001324 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 264199001325 putative active site [active] 264199001326 putative metal binding site [ion binding]; other site 264199001327 homoserine dehydrogenase; Provisional; Region: PRK06349 264199001328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199001329 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 264199001330 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 264199001331 homoserine kinase; Provisional; Region: PRK01212 264199001332 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 264199001333 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 264199001334 Predicted permeases [General function prediction only]; Region: RarD; COG2962 264199001335 EamA-like transporter family; Region: EamA; cl01037 264199001336 Peptidase propeptide and YPEB domain; Region: PepSY; cl15480 264199001337 Flavin Reductases; Region: FlaRed; cl00801 264199001338 Flavin Reductases; Region: FlaRed; cl00801 264199001339 asparagine synthetase-like protein; Provisional; Region: PTZ00077 264199001340 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 264199001341 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 264199001342 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264199001343 active site 264199001344 HIGH motif; other site 264199001345 nucleotide binding site [chemical binding]; other site 264199001346 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 264199001347 active site 264199001348 KMSKS motif; other site 264199001349 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 264199001350 tRNA binding surface [nucleotide binding]; other site 264199001351 anticodon binding site; other site 264199001352 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 264199001353 ATP synthase subunit C; Region: ATP-synt_C; cl00466 264199001354 ATP synthase A chain; Region: ATP-synt_A; cl00413 264199001355 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 264199001356 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 264199001357 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl15360 264199001358 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 264199001359 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 264199001360 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 264199001361 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 264199001362 beta subunit interaction interface [polypeptide binding]; other site 264199001363 Walker A motif; other site 264199001364 ATP binding site [chemical binding]; other site 264199001365 Walker B motif; other site 264199001366 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 264199001367 ATP synthase; Region: ATP-synt; cl00365 264199001368 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 264199001369 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 264199001370 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 264199001371 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 264199001372 alpha subunit interaction interface [polypeptide binding]; other site 264199001373 Walker A motif; other site 264199001374 ATP binding site [chemical binding]; other site 264199001375 Walker B motif; other site 264199001376 inhibitor binding site; inhibition site 264199001377 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 264199001378 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 264199001379 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 264199001380 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 264199001381 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 264199001382 elongation factor Tu; Reviewed; Region: PRK00049 264199001383 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 264199001384 G1 box; other site 264199001385 GEF interaction site [polypeptide binding]; other site 264199001386 GTP/Mg2+ binding site [chemical binding]; other site 264199001387 Switch I region; other site 264199001388 G2 box; other site 264199001389 G3 box; other site 264199001390 Switch II region; other site 264199001391 G4 box; other site 264199001392 G5 box; other site 264199001393 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 264199001394 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 264199001395 Antibiotic Binding Site [chemical binding]; other site 264199001396 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 264199001397 substrate binding site [chemical binding]; other site 264199001398 dimer interface [polypeptide binding]; other site 264199001399 catalytic triad [active] 264199001400 thymidylate kinase; Validated; Region: tmk; PRK00698 264199001401 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 264199001402 TMP-binding site; other site 264199001403 ATP-binding site [chemical binding]; other site 264199001404 DNA polymerase III subunit delta'; Validated; Region: PRK07276 264199001405 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199001406 PSP1 C-terminal conserved region; Region: PSP1; cl00770 264199001407 TSC-22/dip/bun family; Region: TSC22; cl01853 264199001408 Predicted methyltransferases [General function prediction only]; Region: COG0313 264199001409 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 264199001410 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 264199001411 Nitrogen regulatory protein P-II; Region: P-II; cl00412 264199001412 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 264199001413 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264199001414 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 264199001415 active site 264199001416 motif I; other site 264199001417 motif II; other site 264199001418 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264199001419 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 264199001420 PhoU domain; Region: PhoU; pfam01895 264199001421 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 264199001422 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 264199001423 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 264199001424 active site 264199001425 dimer interface [polypeptide binding]; other site 264199001426 Uncharacterized membrane protein [Function unknown]; Region: COG3949 264199001427 Uncharacterized membrane protein [Function unknown]; Region: COG3949 264199001428 Uncharacterized membrane protein [Function unknown]; Region: COG3949 264199001429 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 264199001430 dimer interface [polypeptide binding]; other site 264199001431 motif 1; other site 264199001432 active site 264199001433 motif 2; other site 264199001434 motif 3; other site 264199001435 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 264199001436 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 264199001437 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 264199001438 Amino acid permease; Region: AA_permease; cl00524 264199001439 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 264199001440 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 264199001441 active site turn [active] 264199001442 phosphorylation site [posttranslational modification] 264199001443 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 264199001444 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 264199001445 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 264199001446 HPr interaction site; other site 264199001447 glycerol kinase (GK) interaction site [polypeptide binding]; other site 264199001448 active site 264199001449 phosphorylation site [posttranslational modification] 264199001450 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 264199001451 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 264199001452 active site 264199001453 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264199001454 Helix-turn-helix domains; Region: HTH; cl00088 264199001455 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264199001456 dimerization interface [polypeptide binding]; other site 264199001457 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 264199001458 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 264199001459 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264199001460 RNA binding surface [nucleotide binding]; other site 264199001461 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 264199001462 active site 264199001463 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 264199001464 Permease family; Region: Xan_ur_permease; cl00967 264199001465 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 264199001466 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 264199001467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199001468 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 264199001469 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 264199001470 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 264199001471 catalytic site [active] 264199001472 subunit interface [polypeptide binding]; other site 264199001473 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 264199001474 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264199001475 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 264199001476 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 264199001477 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 264199001478 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 264199001479 IMP binding site; other site 264199001480 dimer interface [polypeptide binding]; other site 264199001481 interdomain contacts; other site 264199001482 partial ornithine binding site; other site 264199001483 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 264199001484 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 264199001485 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 264199001486 FtsX-like permease family; Region: FtsX; pfam02687 264199001487 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 264199001488 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 264199001489 23S rRNA interface [nucleotide binding]; other site 264199001490 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 264199001491 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 264199001492 core dimer interface [polypeptide binding]; other site 264199001493 L10 interface [polypeptide binding]; other site 264199001494 L11 interface [polypeptide binding]; other site 264199001495 putative EF-Tu interaction site [polypeptide binding]; other site 264199001496 putative EF-G interaction site [polypeptide binding]; other site 264199001497 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264199001498 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 264199001499 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199001500 Walker A/P-loop; other site 264199001501 ATP binding site [chemical binding]; other site 264199001502 Q-loop/lid; other site 264199001503 ABC transporter signature motif; other site 264199001504 Walker B; other site 264199001505 D-loop; other site 264199001506 H-loop/switch region; other site 264199001507 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264199001508 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 264199001509 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 264199001510 Walker A/P-loop; other site 264199001511 ATP binding site [chemical binding]; other site 264199001512 Q-loop/lid; other site 264199001513 ABC transporter signature motif; other site 264199001514 Walker B; other site 264199001515 D-loop; other site 264199001516 H-loop/switch region; other site 264199001517 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 264199001518 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 264199001519 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 264199001520 active site 264199001521 trimer interface [polypeptide binding]; other site 264199001522 allosteric site; other site 264199001523 active site lid [active] 264199001524 hexamer (dimer of trimers) interface [polypeptide binding]; other site 264199001525 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 264199001526 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 264199001527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264199001528 active site 264199001529 phosphorylation site [posttranslational modification] 264199001530 intermolecular recognition site; other site 264199001531 dimerization interface [polypeptide binding]; other site 264199001532 LytTr DNA-binding domain; Region: LytTR; cl04498 264199001533 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 264199001534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199001535 ATP binding site [chemical binding]; other site 264199001536 substrate interface [chemical binding]; other site 264199001537 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 264199001538 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199001539 Walker A/P-loop; other site 264199001540 ATP binding site [chemical binding]; other site 264199001541 Q-loop/lid; other site 264199001542 ABC transporter signature motif; other site 264199001543 Walker B; other site 264199001544 D-loop; other site 264199001545 H-loop/switch region; other site 264199001546 ABC-2 type transporter; Region: ABC2_membrane; cl11417 264199001547 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 264199001548 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 264199001549 active site residue [active] 264199001550 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 264199001551 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264199001552 non-specific DNA binding site [nucleotide binding]; other site 264199001553 salt bridge; other site 264199001554 sequence-specific DNA binding site [nucleotide binding]; other site 264199001555 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 264199001556 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 264199001557 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 264199001558 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 264199001559 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 264199001560 active site 264199001561 uracil binding [chemical binding]; other site 264199001562 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 264199001563 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 264199001564 metal binding site [ion binding]; metal-binding site 264199001565 dimer interface [polypeptide binding]; other site 264199001566 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 264199001567 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 264199001568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199001569 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 264199001570 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199001571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199001572 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264199001573 Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435 264199001574 mevalonate kinase; Region: mevalon_kin; TIGR00549 264199001575 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 264199001576 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 264199001577 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 264199001578 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 264199001579 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 264199001580 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 264199001581 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 264199001582 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 264199001583 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 264199001584 homotetramer interface [polypeptide binding]; other site 264199001585 FMN binding site [chemical binding]; other site 264199001586 homodimer contacts [polypeptide binding]; other site 264199001587 putative active site [active] 264199001588 putative substrate binding site [chemical binding]; other site 264199001589 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 264199001590 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 264199001591 Substrate binding site; other site 264199001592 Mg++ binding site; other site 264199001593 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 264199001594 active site 264199001595 substrate binding site [chemical binding]; other site 264199001596 CoA binding site [chemical binding]; other site 264199001597 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 264199001598 dimer interface [polypeptide binding]; other site 264199001599 ADP-ribose binding site [chemical binding]; other site 264199001600 active site 264199001601 nudix motif; other site 264199001602 metal binding site [ion binding]; metal-binding site 264199001603 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 264199001604 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 264199001605 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264199001606 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264199001607 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 264199001608 putative ADP-binding pocket [chemical binding]; other site 264199001609 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 264199001610 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 264199001611 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 264199001612 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 264199001613 active site 264199001614 dimer interface [polypeptide binding]; other site 264199001615 motif 1; other site 264199001616 motif 2; other site 264199001617 motif 3; other site 264199001618 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 264199001619 anticodon binding site; other site 264199001620 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264199001621 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 264199001622 Haemolysin-III related; Region: HlyIII; cl03831 264199001623 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 264199001624 homodimer interface [polypeptide binding]; other site 264199001625 NAD binding site [chemical binding]; other site 264199001626 catalytic residues [active] 264199001627 substrate binding pocket [chemical binding]; other site 264199001628 flexible flap; other site 264199001629 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 264199001630 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 264199001631 dimer interface [polypeptide binding]; other site 264199001632 active site 264199001633 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 264199001634 dimerization interface [polypeptide binding]; other site 264199001635 active site 264199001636 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 264199001637 folate binding site [chemical binding]; other site 264199001638 NADP+ binding site [chemical binding]; other site 264199001639 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 264199001640 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 264199001641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264199001642 Walker A motif; other site 264199001643 ATP binding site [chemical binding]; other site 264199001644 Walker B motif; other site 264199001645 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 264199001646 Predicted GTPase [General function prediction only]; Region: COG0218 264199001647 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 264199001648 G1 box; other site 264199001649 GTP/Mg2+ binding site [chemical binding]; other site 264199001650 Switch I region; other site 264199001651 G2 box; other site 264199001652 G3 box; other site 264199001653 Switch II region; other site 264199001654 G4 box; other site 264199001655 G5 box; other site 264199001656 Amino acid permease; Region: AA_permease; cl00524 264199001657 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 264199001658 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 264199001659 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 264199001660 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 264199001661 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 264199001662 Domain of unknown function (DUF205); Region: DUF205; cl00410 264199001663 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 264199001664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 264199001665 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 264199001666 anchoring element; other site 264199001667 dimer interface [polypeptide binding]; other site 264199001668 ATP binding site [chemical binding]; other site 264199001669 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 264199001670 active site 264199001671 putative metal-binding site [ion binding]; other site 264199001672 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 264199001673 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 264199001674 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 264199001675 CAP-like domain; other site 264199001676 active site 264199001677 primary dimer interface [polypeptide binding]; other site 264199001678 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264199001679 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 264199001680 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 264199001681 homodimer interface [polypeptide binding]; other site 264199001682 substrate-cofactor binding pocket; other site 264199001683 catalytic residue [active] 264199001684 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 264199001685 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 264199001686 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 264199001687 RNA binding site [nucleotide binding]; other site 264199001688 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 264199001689 RNA binding site [nucleotide binding]; other site 264199001690 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 264199001691 RNA binding site [nucleotide binding]; other site 264199001692 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 264199001693 RNA binding site [nucleotide binding]; other site 264199001694 Domain of Unknown Function with PDB structure; Region: DUF3862; pfam12978 264199001695 Domain of Unknown Function with PDB structure; Region: DUF3862; pfam12978 264199001696 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 264199001697 FemAB family; Region: FemAB; cl11444 264199001698 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199001699 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 264199001700 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 264199001701 nudix motif; other site 264199001702 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 264199001703 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264199001704 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264199001705 Walker A motif; other site 264199001706 ATP binding site [chemical binding]; other site 264199001707 Walker B motif; other site 264199001708 arginine finger; other site 264199001709 Helicase subunit of the DNA excision repair complex [DNA replication, recombination, and repair]; Region: UvrB; COG0556 264199001710 UvrB/uvrC motif; Region: UVR; pfam02151 264199001711 ATP-dependent protease Clp, ATPase subunit [Posttranslational modification, protein turnover, chaperones]; Region: ClpX; COG1219 264199001712 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264199001713 Walker A motif; other site 264199001714 ATP binding site [chemical binding]; other site 264199001715 Walker B motif; other site 264199001716 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 264199001717 ornithine carbamoyltransferase; Validated; Region: PRK02102 264199001718 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 264199001719 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199001720 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 264199001721 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264199001722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264199001723 dimer interface [polypeptide binding]; other site 264199001724 conserved gate region; other site 264199001725 putative PBP binding loops; other site 264199001726 ABC-ATPase subunit interface; other site 264199001727 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264199001728 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 264199001729 Walker A/P-loop; other site 264199001730 ATP binding site [chemical binding]; other site 264199001731 Q-loop/lid; other site 264199001732 ABC transporter signature motif; other site 264199001733 Walker B; other site 264199001734 D-loop; other site 264199001735 H-loop/switch region; other site 264199001736 FeoA domain; Region: FeoA; cl00838 264199001737 FeoA domain; Region: FeoA; cl00838 264199001738 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 264199001739 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 264199001740 G1 box; other site 264199001741 GTP/Mg2+ binding site [chemical binding]; other site 264199001742 Switch I region; other site 264199001743 G2 box; other site 264199001744 G3 box; other site 264199001745 Switch II region; other site 264199001746 G4 box; other site 264199001747 G5 box; other site 264199001748 Nucleoside recognition; Region: Gate; cl00486 264199001749 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 264199001750 Nucleoside recognition; Region: Gate; cl00486 264199001751 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264199001752 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 264199001753 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 264199001754 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 264199001755 homodimer interface [polypeptide binding]; other site 264199001756 NADP binding site [chemical binding]; other site 264199001757 substrate binding site [chemical binding]; other site 264199001758 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 264199001759 putative substrate binding site [chemical binding]; other site 264199001760 putative ATP binding site [chemical binding]; other site 264199001761 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 264199001762 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 264199001763 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 264199001764 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264199001765 recombination protein RecR; Reviewed; Region: recR; PRK00076 264199001766 RecR protein; Region: RecR; pfam02132 264199001767 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 264199001768 putative active site [active] 264199001769 putative metal-binding site [ion binding]; other site 264199001770 tetramer interface [polypeptide binding]; other site 264199001771 CAT RNA binding domain; Region: CAT_RBD; cl03904 264199001772 PRD domain; Region: PRD; cl15445 264199001773 PRD domain; Region: PRD; cl15445 264199001774 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 264199001775 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 264199001776 GTPase Era; Reviewed; Region: era; PRK00089 264199001777 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly...; Region: Era; cd04163 264199001778 G1 box; other site 264199001779 GTP/Mg2+ binding site [chemical binding]; other site 264199001780 Switch I region; other site 264199001781 G2 box; other site 264199001782 Switch II region; other site 264199001783 G3 box; other site 264199001784 G4 box; other site 264199001785 G5 box; other site 264199001786 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 264199001787 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 264199001788 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 264199001789 DNA binding site [nucleotide binding] 264199001790 catalytic residue [active] 264199001791 H2TH interface [polypeptide binding]; other site 264199001792 putative catalytic residues [active] 264199001793 turnover-facilitating residue; other site 264199001794 intercalation triad [nucleotide binding]; other site 264199001795 8OG recognition residue [nucleotide binding]; other site 264199001796 putative reading head residues; other site 264199001797 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 264199001798 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 264199001799 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 264199001800 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 264199001801 CoA-binding site [chemical binding]; other site 264199001802 ATP-binding [chemical binding]; other site 264199001803 drug efflux system protein MdtG; Provisional; Region: PRK09874 264199001804 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264199001805 putative substrate translocation pore; other site 264199001806 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 264199001807 Preprotein translocase SecG subunit; Region: SecG; cl09123 264199001808 ribonuclease R; Region: RNase_R; TIGR02063 264199001809 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 264199001810 RNB domain; Region: RNB; pfam00773 264199001811 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 264199001812 RNA binding site [nucleotide binding]; other site 264199001813 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 264199001814 SmpB-tmRNA interface; other site 264199001815 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 264199001816 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264199001817 active site 264199001818 motif I; other site 264199001819 motif II; other site 264199001820 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264199001821 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 264199001822 active site 264199001823 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 264199001824 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 264199001825 RNA binding site [nucleotide binding]; other site 264199001826 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 264199001827 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 264199001828 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 264199001829 active site 264199001830 catabolite control protein A; Region: ccpA; TIGR01481 264199001831 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264199001832 DNA binding site [nucleotide binding] 264199001833 domain linker motif; other site 264199001834 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 264199001835 dimerization interface [polypeptide binding]; other site 264199001836 effector binding site; other site 264199001837 Protein of unknown function (DUF419); Region: DUF419; cl15265 264199001838 Glycerate kinase family; Region: Gly_kinase; cl00841 264199001839 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 264199001840 enolase; Provisional; Region: eno; PRK00077 264199001841 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 264199001842 dimer interface [polypeptide binding]; other site 264199001843 metal binding site [ion binding]; metal-binding site 264199001844 substrate binding pocket [chemical binding]; other site 264199001845 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 264199001846 Sulfatase; Region: Sulfatase; cl10460 264199001847 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 264199001848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 264199001849 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 264199001850 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 264199001851 active site 264199001852 catalytic residue [active] 264199001853 dimer interface [polypeptide binding]; other site 264199001854 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 264199001855 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 264199001856 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 264199001857 shikimate binding site; other site 264199001858 NAD(P) binding site [chemical binding]; other site 264199001859 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 264199001860 active site 264199001861 dimer interface [polypeptide binding]; other site 264199001862 metal binding site [ion binding]; metal-binding site 264199001863 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 264199001864 Tetramer interface [polypeptide binding]; other site 264199001865 active site 264199001866 FMN-binding site [chemical binding]; other site 264199001867 prephenate dehydrogenase; Validated; Region: PRK06545 264199001868 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199001869 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 264199001870 Protein of unknown function (DUF964); Region: DUF964; cl01483 264199001871 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 264199001872 tetramer (dimer of dimers) interface [polypeptide binding]; other site 264199001873 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 264199001874 NAD binding site [chemical binding]; other site 264199001875 dimer interface [polypeptide binding]; other site 264199001876 substrate binding site [chemical binding]; other site 264199001877 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 264199001878 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 264199001879 putative active site [active] 264199001880 shikimate kinase; Reviewed; Region: aroK; PRK00131 264199001881 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 264199001882 ADP binding site [chemical binding]; other site 264199001883 magnesium binding site [ion binding]; other site 264199001884 putative shikimate binding site; other site 264199001885 prephenate dehydratase; Provisional; Region: PRK11898 264199001886 Prephenate dehydratase; Region: PDT; pfam00800 264199001887 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 264199001888 putative L-Phe binding site [chemical binding]; other site 264199001889 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 264199001890 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 264199001891 gating phenylalanine in ion channel; other site 264199001892 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 264199001893 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 264199001894 active site 264199001895 Uncharacterized conserved protein [Function unknown]; Region: COG2128 264199001896 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 264199001897 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 264199001898 TRAM domain; Region: TRAM; cl01282 264199001899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264199001900 S-adenosylmethionine binding site [chemical binding]; other site 264199001901 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 264199001902 GIY-YIG motif/motif A; other site 264199001903 putative active site [active] 264199001904 putative metal binding site [ion binding]; other site 264199001905 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 264199001906 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 264199001907 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 264199001908 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 264199001909 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 264199001910 Predicted permease; Region: DUF318; cl00487 264199001911 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 264199001912 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 264199001913 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 264199001914 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 264199001915 RNA binding site [nucleotide binding]; other site 264199001916 hypothetical protein; Provisional; Region: PRK04351 264199001917 SprT homologues; Region: SprT; cl01182 264199001918 PspC domain; Region: PspC; cl00864 264199001919 HPr kinase/phosphorylase; Provisional; Region: PRK05428 264199001920 DRTGG domain; Region: DRTGG; cl12147 264199001921 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 264199001922 Hpr binding site; other site 264199001923 active site 264199001924 homohexamer subunit interaction site [polypeptide binding]; other site 264199001925 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 264199001926 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 264199001927 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 264199001928 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; Provisional; Region: PRK13585 264199001929 Peptidase family U32; Region: Peptidase_U32; cl03113 264199001930 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 264199001931 Peptidase family U32; Region: Peptidase_U32; cl03113 264199001932 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 264199001933 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; cl01839 264199001934 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 264199001935 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 264199001936 active site 264199001937 8-oxo-dGMP binding site [chemical binding]; other site 264199001938 nudix motif; other site 264199001939 metal binding site [ion binding]; metal-binding site 264199001940 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 264199001941 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199001942 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264199001943 nucleotide binding region [chemical binding]; other site 264199001944 ATP-binding site [chemical binding]; other site 264199001945 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 264199001946 Predicted HKD family nuclease [DNA replication, recombination, and repair]; Region: COG3886 264199001947 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 264199001948 putative homodimer interface [polypeptide binding]; other site 264199001949 putative active site [active] 264199001950 catalytic site [active] 264199001951 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 264199001952 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 264199001953 dimer interface [polypeptide binding]; other site 264199001954 putative anticodon binding site; other site 264199001955 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 264199001956 motif 1; other site 264199001957 active site 264199001958 motif 2; other site 264199001959 motif 3; other site 264199001960 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 264199001961 putative peptidoglycan binding site; other site 264199001962 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 264199001963 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264199001964 motif II; other site 264199001965 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264199001966 catalytic core [active] 264199001967 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 264199001968 putative deacylase active site [active] 264199001969 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 264199001970 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 264199001971 active site 264199001972 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 264199001973 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 264199001974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199001975 NAD(P) binding site [chemical binding]; other site 264199001976 active site 264199001977 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 264199001978 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 264199001979 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264199001980 ATP binding site [chemical binding]; other site 264199001981 putative Mg++ binding site [ion binding]; other site 264199001982 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 264199001983 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 264199001984 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 264199001985 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 264199001986 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 264199001987 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 264199001988 HsdM N-terminal domain; Region: HsdM_N; pfam12161 264199001989 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 264199001990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 264199001991 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 264199001992 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 264199001993 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 264199001994 LemA family; Region: LemA; cl00742 264199001995 Peptidase family M48; Region: Peptidase_M48; cl12018 264199001996 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 264199001997 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 264199001998 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 264199001999 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 264199002000 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 264199002001 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 264199002002 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 264199002003 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 264199002004 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264199002005 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 264199002006 Ferritin-like domain; Region: Ferritin; pfam00210 264199002007 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 264199002008 dimerization interface [polypeptide binding]; other site 264199002009 DPS ferroxidase diiron center [ion binding]; other site 264199002010 ion pore; other site 264199002011 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 264199002012 metal binding site 2 [ion binding]; metal-binding site 264199002013 putative DNA binding helix; other site 264199002014 metal binding site 1 [ion binding]; metal-binding site 264199002015 dimer interface [polypeptide binding]; other site 264199002016 structural Zn2+ binding site [ion binding]; other site 264199002017 Helix-turn-helix domains; Region: HTH; cl00088 264199002018 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 264199002019 Integrase core domain; Region: rve; cl01316 264199002020 Bacterial protein of unknown function (DUF910); Region: DUF910; cl11543 264199002021 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 264199002022 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 264199002023 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 264199002024 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 264199002025 G1 box; other site 264199002026 putative GEF interaction site [polypeptide binding]; other site 264199002027 GTP/Mg2+ binding site [chemical binding]; other site 264199002028 Switch I region; other site 264199002029 G2 box; other site 264199002030 G3 box; other site 264199002031 Switch II region; other site 264199002032 G4 box; other site 264199002033 G5 box; other site 264199002034 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 264199002035 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 264199002036 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 264199002037 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 264199002038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199002039 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 264199002040 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264199002041 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 264199002042 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 264199002043 homodimer interface [polypeptide binding]; other site 264199002044 active site 264199002045 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 264199002046 Cell division protein FtsQ; Region: FtsQ; pfam03799 264199002047 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 264199002048 Cell division protein FtsA; Region: FtsA; cl11496 264199002049 Cell division protein FtsA; Region: FtsA; cl11496 264199002050 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 264199002051 cell division protein FtsZ; Validated; Region: PRK09330 264199002052 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 264199002053 nucleotide binding site [chemical binding]; other site 264199002054 SulA interaction site; other site 264199002055 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 264199002056 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264199002057 catalytic residue [active] 264199002058 Protein of unknown function (DUF552); Region: DUF552; cl00775 264199002059 YGGT family; Region: YGGT; cl00508 264199002060 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 264199002061 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264199002062 RNA binding surface [nucleotide binding]; other site 264199002063 DivIVA protein; Region: DivIVA; pfam05103 264199002064 DivIVA domain; Region: DivI1A_domain; TIGR03544 264199002065 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 264199002066 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 264199002067 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264199002068 active site 264199002069 HIGH motif; other site 264199002070 nucleotide binding site [chemical binding]; other site 264199002071 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 264199002072 active site 264199002073 KMSKS motif; other site 264199002074 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 264199002075 tRNA binding surface [nucleotide binding]; other site 264199002076 anticodon binding site; other site 264199002077 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 264199002078 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264199002079 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 264199002080 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 264199002081 ApbE family; Region: ApbE; cl00643 264199002082 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 264199002083 DHH family; Region: DHH; pfam01368 264199002084 putative S-transferase; Provisional; Region: PRK11752 264199002085 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 264199002086 C-terminal domain interface [polypeptide binding]; other site 264199002087 GSH binding site (G-site) [chemical binding]; other site 264199002088 dimer interface [polypeptide binding]; other site 264199002089 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 264199002090 dimer interface [polypeptide binding]; other site 264199002091 N-terminal domain interface [polypeptide binding]; other site 264199002092 active site 264199002093 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 264199002094 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264199002095 active site 264199002096 Thymidine kinase; Region: TK; cl00631 264199002097 peptide chain release factor 1; Validated; Region: prfA; PRK00591 264199002098 RF-1 domain; Region: RF-1; cl02875 264199002099 RF-1 domain; Region: RF-1; cl02875 264199002100 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 264199002101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 264199002102 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 264199002103 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 264199002104 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 264199002105 dimer interface [polypeptide binding]; other site 264199002106 glycine-pyridoxal phosphate binding site [chemical binding]; other site 264199002107 active site 264199002108 folate binding site [chemical binding]; other site 264199002109 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 264199002110 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 264199002111 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264199002112 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 264199002113 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199002114 Walker A/P-loop; other site 264199002115 ATP binding site [chemical binding]; other site 264199002116 Q-loop/lid; other site 264199002117 ABC transporter signature motif; other site 264199002118 Walker B; other site 264199002119 D-loop; other site 264199002120 H-loop/switch region; other site 264199002121 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264199002122 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 264199002123 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 264199002124 Walker A/P-loop; other site 264199002125 ATP binding site [chemical binding]; other site 264199002126 Q-loop/lid; other site 264199002127 ABC transporter signature motif; other site 264199002128 Walker B; other site 264199002129 D-loop; other site 264199002130 H-loop/switch region; other site 264199002131 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 264199002132 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 264199002133 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 264199002134 MBOAT family; Region: MBOAT; cl00738 264199002135 Phosphopantetheine attachment site; Region: PP-binding; cl09936 264199002136 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 264199002137 DltD N-terminal region; Region: DltD_N; pfam04915 264199002138 DltD central region; Region: DltD_M; pfam04918 264199002139 DltD C-terminal region; Region: DltD_C; pfam04914 264199002140 putative transposase OrfB; Reviewed; Region: PHA02517 264199002141 Integrase core domain; Region: rve; cl01316 264199002142 putative transposase OrfB; Reviewed; Region: PHA02517 264199002143 Hydantoinase B/oxoprolinase; Region: Hydantoinase_B; pfam02538 264199002144 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 264199002145 plasma-membrane calcium-translocating P-type ATPase; Region: ATPase-IIB_Ca; TIGR01517 264199002146 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264199002147 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264199002148 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 264199002149 anthranilate synthase component I; Reviewed; Region: PRK06404 264199002150 chorismate binding enzyme; Region: Chorismate_bind; cl10555 264199002151 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 264199002152 substrate-cofactor binding pocket; other site 264199002153 homodimer interface [polypeptide binding]; other site 264199002154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264199002155 catalytic residue [active] 264199002156 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 264199002157 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 264199002158 THF binding site; other site 264199002159 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 264199002160 substrate binding site [chemical binding]; other site 264199002161 THF binding site; other site 264199002162 zinc-binding site [ion binding]; other site 264199002163 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 264199002164 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 264199002165 FAD binding site [chemical binding]; other site 264199002166 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 264199002167 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 264199002168 active site 264199002169 substrate binding site [chemical binding]; other site 264199002170 metal binding site [ion binding]; metal-binding site 264199002171 Predicted membrane protein [Function unknown]; Region: COG4684 264199002172 Flavoprotein; Region: Flavoprotein; cl08021 264199002173 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 264199002174 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 264199002175 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 264199002176 Potassium binding sites [ion binding]; other site 264199002177 Cesium cation binding sites [ion binding]; other site 264199002178 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264199002179 active site 264199002180 phosphorylation site [posttranslational modification] 264199002181 intermolecular recognition site; other site 264199002182 dimerization interface [polypeptide binding]; other site 264199002183 Helix-turn-helix domains; Region: HTH; cl00088 264199002184 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264199002185 dimer interface [polypeptide binding]; other site 264199002186 phosphorylation site [posttranslational modification] 264199002187 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264199002188 ATP binding site [chemical binding]; other site 264199002189 Mg2+ binding site [ion binding]; other site 264199002190 G-X-G motif; other site 264199002191 putative transposase OrfB; Reviewed; Region: PHA02517 264199002192 Integrase core domain; Region: rve; cl01316 264199002193 Helix-turn-helix domains; Region: HTH; cl00088 264199002194 Helix-turn-helix domains; Region: HTH; cl00088 264199002195 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264199002196 Helix-turn-helix domains; Region: HTH; cl00088 264199002197 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 264199002198 pantothenate kinase; Provisional; Region: PRK05439 264199002199 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 264199002200 ATP-binding site [chemical binding]; other site 264199002201 CoA-binding site [chemical binding]; other site 264199002202 Mg2+-binding site [ion binding]; other site 264199002203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264199002204 S-adenosylmethionine binding site [chemical binding]; other site 264199002205 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 264199002206 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 264199002207 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 264199002208 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 264199002209 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 264199002210 active site 264199002211 catalytic residue [active] 264199002212 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 264199002213 active site 264199002214 catalytic motif [active] 264199002215 Zn binding site [ion binding]; other site 264199002216 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 264199002217 ligand binding site [chemical binding]; other site 264199002218 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 264199002219 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 264199002220 Walker A/P-loop; other site 264199002221 ATP binding site [chemical binding]; other site 264199002222 Q-loop/lid; other site 264199002223 ABC transporter signature motif; other site 264199002224 Walker B; other site 264199002225 D-loop; other site 264199002226 H-loop/switch region; other site 264199002227 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 264199002228 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 264199002229 TM-ABC transporter signature motif; other site 264199002230 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 264199002231 TM-ABC transporter signature motif; other site 264199002232 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264199002233 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 264199002234 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 264199002235 active site 264199002236 substrate binding site [chemical binding]; other site 264199002237 catalytic site [active] 264199002238 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199002239 ATP binding site [chemical binding]; other site 264199002240 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 264199002241 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199002242 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 264199002243 aspartate aminotransferase; Provisional; Region: PRK05764 264199002244 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264199002245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264199002246 homodimer interface [polypeptide binding]; other site 264199002247 catalytic residue [active] 264199002248 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 264199002249 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 264199002250 putative dimer interface [polypeptide binding]; other site 264199002251 putative anticodon binding site; other site 264199002252 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 264199002253 homodimer interface [polypeptide binding]; other site 264199002254 motif 1; other site 264199002255 motif 2; other site 264199002256 active site 264199002257 motif 3; other site 264199002258 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 264199002259 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264199002260 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 264199002261 homotrimer interaction site [polypeptide binding]; other site 264199002262 putative active site [active] 264199002263 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 264199002264 Ligand Binding Site [chemical binding]; other site 264199002265 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 264199002266 active site 264199002267 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 264199002268 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 264199002269 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 264199002270 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199002271 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 264199002272 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 264199002273 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 264199002274 dimer interface [polypeptide binding]; other site 264199002275 phosphate binding site [ion binding]; other site 264199002276 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 264199002277 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 264199002278 Peptidase family C69; Region: Peptidase_C69; cl01920 264199002279 Peptidase family C69; Region: Peptidase_C69; cl01920 264199002280 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 264199002281 DNA-binding site [nucleotide binding]; DNA binding site 264199002282 RNA-binding motif; other site 264199002283 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 264199002284 DNA-binding site [nucleotide binding]; DNA binding site 264199002285 RNA-binding motif; other site 264199002286 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264199002287 MULE transposase domain; Region: MULE; pfam10551 264199002288 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 264199002289 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264199002290 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264199002291 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264199002292 MULE transposase domain; Region: MULE; pfam10551 264199002293 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264199002294 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 264199002295 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199002296 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 264199002297 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 264199002298 dimer interface [polypeptide binding]; other site 264199002299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264199002300 catalytic residue [active] 264199002301 cystathionine beta-lyase; Provisional; Region: PRK07671 264199002302 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 264199002303 homodimer interface [polypeptide binding]; other site 264199002304 substrate-cofactor binding pocket; other site 264199002305 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264199002306 catalytic residue [active] 264199002307 serine O-acetyltransferase; Region: cysE; TIGR01172 264199002308 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 264199002309 trimer interface [polypeptide binding]; other site 264199002310 active site 264199002311 substrate binding site [chemical binding]; other site 264199002312 CoA binding site [chemical binding]; other site 264199002313 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264199002314 MULE transposase domain; Region: MULE; pfam10551 264199002315 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 264199002316 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 264199002317 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 264199002318 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 264199002319 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl01939 264199002320 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 264199002321 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 264199002322 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 264199002323 metal binding site [ion binding]; metal-binding site 264199002324 YodA lipocalin-like domain; Region: YodA; cl01365 264199002325 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 264199002326 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 264199002327 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264199002328 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 264199002329 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264199002330 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 264199002331 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 264199002332 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl00743 264199002333 Integrase core domain; Region: rve; cl01316 264199002334 Transcriptional regulator [Transcription]; Region: LysR; COG0583 264199002335 Helix-turn-helix domains; Region: HTH; cl00088 264199002336 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 264199002337 dimerization interface [polypeptide binding]; other site 264199002338 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 264199002339 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 264199002340 glutaminase active site [active] 264199002341 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 264199002342 dimer interface [polypeptide binding]; other site 264199002343 active site 264199002344 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 264199002345 dimer interface [polypeptide binding]; other site 264199002346 active site 264199002347 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 264199002348 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 264199002349 PhnA protein; Region: PhnA; pfam03831 264199002350 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264199002351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264199002352 dimer interface [polypeptide binding]; other site 264199002353 conserved gate region; other site 264199002354 ABC-ATPase subunit interface; other site 264199002355 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264199002356 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199002357 Walker A/P-loop; other site 264199002358 ATP binding site [chemical binding]; other site 264199002359 Q-loop/lid; other site 264199002360 ABC transporter signature motif; other site 264199002361 Walker B; other site 264199002362 D-loop; other site 264199002363 H-loop/switch region; other site 264199002364 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264199002365 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264199002366 substrate binding pocket [chemical binding]; other site 264199002367 membrane-bound complex binding site; other site 264199002368 hinge residues; other site 264199002369 Y-family of DNA polymerases; Region: PolY; cl12025 264199002370 Y-family of DNA polymerases; Region: PolY; cl12025 264199002371 DNA binding site [nucleotide binding] 264199002372 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 264199002373 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 264199002374 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 264199002375 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199002376 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199002377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 264199002378 ATP binding site [chemical binding]; other site 264199002379 putative Mg++ binding site [ion binding]; other site 264199002380 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 264199002381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 264199002382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 264199002383 GMP synthase; Reviewed; Region: guaA; PRK00074 264199002384 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 264199002385 AMP/PPi binding site [chemical binding]; other site 264199002386 candidate oxyanion hole; other site 264199002387 catalytic triad [active] 264199002388 potential glutamine specificity residues [chemical binding]; other site 264199002389 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 264199002390 ATP Binding subdomain [chemical binding]; other site 264199002391 Dimerization subdomain; other site 264199002392 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 264199002393 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264199002394 DNA-binding site [nucleotide binding]; DNA binding site 264199002395 UTRA domain; Region: UTRA; cl01230 264199002396 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 264199002397 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 264199002398 signal recognition particle protein; Provisional; Region: PRK10867 264199002399 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 264199002400 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 264199002401 P loop; other site 264199002402 GTP binding site [chemical binding]; other site 264199002403 Signal peptide binding domain; Region: SRP_SPB; pfam02978 264199002404 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 264199002405 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 264199002406 Helix-turn-helix domains; Region: HTH; cl00088 264199002407 3H domain; Region: 3H; pfam02829 264199002408 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264199002409 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 264199002410 non-specific DNA binding site [nucleotide binding]; other site 264199002411 salt bridge; other site 264199002412 sequence-specific DNA binding site [nucleotide binding]; other site 264199002413 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 264199002414 Catalytic site [active] 264199002415 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 264199002416 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The...; Region: YlqF; cd01856 264199002417 GTP/Mg2+ binding site [chemical binding]; other site 264199002418 G4 box; other site 264199002419 G5 box; other site 264199002420 G1 box; other site 264199002421 Switch I region; other site 264199002422 G2 box; other site 264199002423 G3 box; other site 264199002424 Switch II region; other site 264199002425 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 264199002426 RNA/DNA hybrid binding site [nucleotide binding]; other site 264199002427 active site 264199002428 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 264199002429 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 264199002430 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 264199002431 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 264199002432 DNA topoisomerase I; Validated; Region: PRK05582 264199002433 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 264199002434 active site 264199002435 interdomain interaction site; other site 264199002436 putative metal-binding site [ion binding]; other site 264199002437 nucleotide binding site [chemical binding]; other site 264199002438 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 264199002439 domain I; other site 264199002440 DNA binding groove [nucleotide binding] 264199002441 phosphate binding site [ion binding]; other site 264199002442 domain II; other site 264199002443 domain III; other site 264199002444 nucleotide binding site [chemical binding]; other site 264199002445 catalytic site [active] 264199002446 domain IV; other site 264199002447 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 264199002448 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 264199002449 putative transposase OrfB; Reviewed; Region: PHA02517 264199002450 Integrase core domain; Region: rve; cl01316 264199002451 Helix-turn-helix domains; Region: HTH; cl00088 264199002452 Helix-turn-helix domains; Region: HTH; cl00088 264199002453 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264199002454 Helix-turn-helix domains; Region: HTH; cl00088 264199002455 TraX protein; Region: TraX; cl05434 264199002456 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264199002457 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264199002458 active site 264199002459 phosphorylation site [posttranslational modification] 264199002460 intermolecular recognition site; other site 264199002461 dimerization interface [polypeptide binding]; other site 264199002462 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264199002463 DNA binding site [nucleotide binding] 264199002464 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264199002465 dimer interface [polypeptide binding]; other site 264199002466 phosphorylation site [posttranslational modification] 264199002467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264199002468 ATP binding site [chemical binding]; other site 264199002469 Mg2+ binding site [ion binding]; other site 264199002470 G-X-G motif; other site 264199002471 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 264199002472 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 264199002473 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 264199002474 substrate binding site [chemical binding]; other site 264199002475 THF binding site; other site 264199002476 zinc-binding site [ion binding]; other site 264199002477 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 264199002478 active site 264199002479 multimer interface [polypeptide binding]; other site 264199002480 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 264199002481 active site residue [active] 264199002482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199002483 NAD(P) binding site [chemical binding]; other site 264199002484 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199002485 GTP-binding protein LepA; Provisional; Region: PRK05433 264199002486 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 264199002487 G1 box; other site 264199002488 putative GEF interaction site [polypeptide binding]; other site 264199002489 GTP/Mg2+ binding site [chemical binding]; other site 264199002490 Switch I region; other site 264199002491 G2 box; other site 264199002492 G3 box; other site 264199002493 Switch II region; other site 264199002494 G4 box; other site 264199002495 G5 box; other site 264199002496 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 264199002497 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 264199002498 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 264199002499 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 264199002500 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264199002501 non-specific DNA binding site [nucleotide binding]; other site 264199002502 salt bridge; other site 264199002503 sequence-specific DNA binding site [nucleotide binding]; other site 264199002504 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 264199002505 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264199002506 non-specific DNA binding site [nucleotide binding]; other site 264199002507 salt bridge; other site 264199002508 sequence-specific DNA binding site [nucleotide binding]; other site 264199002509 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 264199002510 Flagellin N-methylase; Region: FliB; cl00497 264199002511 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 264199002512 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264199002513 FeS/SAM binding site; other site 264199002514 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; cl14869 264199002515 Arginase family; Region: Arginase; cl00306 264199002516 acetolactate synthase; Reviewed; Region: PRK08617 264199002517 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 264199002518 PYR/PP interface [polypeptide binding]; other site 264199002519 dimer interface [polypeptide binding]; other site 264199002520 TPP binding site [chemical binding]; other site 264199002521 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 264199002522 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 264199002523 TPP-binding site [chemical binding]; other site 264199002524 dimer interface [polypeptide binding]; other site 264199002525 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408 264199002526 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 264199002527 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264199002528 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 264199002529 FtsX-like permease family; Region: FtsX; pfam02687 264199002530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199002531 NAD(P) binding site [chemical binding]; other site 264199002532 active site 264199002533 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264199002534 Helix-turn-helix domains; Region: HTH; cl00088 264199002535 Cation efflux family; Region: Cation_efflux; cl00316 264199002536 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 264199002537 active site 264199002538 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 264199002539 active site 264199002540 N-terminal domain interface [polypeptide binding]; other site 264199002541 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 264199002542 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 264199002543 catalytic Zn binding site [ion binding]; other site 264199002544 NAD(P) binding site [chemical binding]; other site 264199002545 structural Zn binding site [ion binding]; other site 264199002546 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264199002547 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264199002548 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 264199002549 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 264199002550 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264199002551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264199002552 motif II; other site 264199002553 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 264199002554 intersubunit interface [polypeptide binding]; other site 264199002555 MatE; Region: MatE; cl10513 264199002556 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 264199002557 MatE; Region: MatE; cl10513 264199002558 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 264199002559 Domain of unknown function (DUF814); Region: DUF814; pfam05670 264199002560 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 264199002561 conserved cys residue [active] 264199002562 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 264199002563 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 264199002564 FAD binding pocket [chemical binding]; other site 264199002565 FAD binding motif [chemical binding]; other site 264199002566 phosphate binding motif [ion binding]; other site 264199002567 beta-alpha-beta structure motif; other site 264199002568 NAD binding pocket [chemical binding]; other site 264199002569 Iron coordination center [ion binding]; other site 264199002570 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 264199002571 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 264199002572 heterodimer interface [polypeptide binding]; other site 264199002573 active site 264199002574 FMN binding site [chemical binding]; other site 264199002575 homodimer interface [polypeptide binding]; other site 264199002576 substrate binding site [chemical binding]; other site 264199002577 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 264199002578 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 264199002579 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 264199002580 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 264199002581 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 264199002582 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 264199002583 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 264199002584 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 264199002585 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 264199002586 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 264199002587 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 264199002588 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 264199002589 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 264199002590 active site 264199002591 dimer interface [polypeptide binding]; other site 264199002592 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 264199002593 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 264199002594 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 264199002595 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264199002596 putative substrate translocation pore; other site 264199002597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 264199002598 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 264199002599 Integrase core domain; Region: rve; cl01316 264199002600 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 264199002601 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264199002602 substrate binding pocket [chemical binding]; other site 264199002603 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl15306 264199002604 membrane-bound complex binding site; other site 264199002605 hinge residues; other site 264199002606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264199002607 dimer interface [polypeptide binding]; other site 264199002608 conserved gate region; other site 264199002609 ABC-ATPase subunit interface; other site 264199002610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 264199002611 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 264199002612 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 264199002613 active site 264199002614 metal binding site [ion binding]; metal-binding site 264199002615 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 264199002616 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 264199002617 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 264199002618 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 264199002619 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 264199002620 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 264199002621 G1 box; other site 264199002622 GTP/Mg2+ binding site [chemical binding]; other site 264199002623 Switch I region; other site 264199002624 G2 box; other site 264199002625 Switch II region; other site 264199002626 G3 box; other site 264199002627 G4 box; other site 264199002628 G5 box; other site 264199002629 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 264199002630 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 264199002631 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 264199002632 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199002633 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 264199002634 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 264199002635 homodimer interface [polypeptide binding]; other site 264199002636 substrate-cofactor binding pocket; other site 264199002637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264199002638 catalytic residue [active] 264199002639 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 264199002640 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 264199002641 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 264199002642 dimer interface [polypeptide binding]; other site 264199002643 catalytic triad [active] 264199002644 peroxidatic and resolving cysteines [active] 264199002645 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 264199002646 Domain of unknown function (DUF1858); Region: DUF1858; cl14817 264199002647 Uncharacterized conserved protein [Function unknown]; Region: COG2461 264199002648 Family of unknown function (DUF438); Region: DUF438; pfam04282 264199002649 Uncharacterized conserved protein [Function unknown]; Region: COG2461 264199002650 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 264199002651 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 264199002652 RNA binding site [nucleotide binding]; other site 264199002653 active site 264199002654 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 264199002655 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 264199002656 active site 264199002657 Riboflavin kinase; Region: Flavokinase; cl03312 264199002658 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 264199002659 ArsC family; Region: ArsC; pfam03960 264199002660 putative catalytic residues [active] 264199002661 thiol/disulfide switch; other site 264199002662 Uncharacterised protein family (UPF0223); Region: UPF0223; cl11484 264199002663 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 264199002664 active site 264199002665 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 264199002666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264199002667 S-adenosylmethionine binding site [chemical binding]; other site 264199002668 Uncharacterized conserved protein [Function unknown]; Region: COG3270 264199002669 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264199002670 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 264199002671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264199002672 dimer interface [polypeptide binding]; other site 264199002673 conserved gate region; other site 264199002674 putative PBP binding loops; other site 264199002675 ABC-ATPase subunit interface; other site 264199002676 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 264199002677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264199002678 dimer interface [polypeptide binding]; other site 264199002679 conserved gate region; other site 264199002680 putative PBP binding loops; other site 264199002681 ABC-ATPase subunit interface; other site 264199002682 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 264199002683 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 264199002684 Walker A/P-loop; other site 264199002685 ATP binding site [chemical binding]; other site 264199002686 Q-loop/lid; other site 264199002687 ABC transporter signature motif; other site 264199002688 Walker B; other site 264199002689 D-loop; other site 264199002690 H-loop/switch region; other site 264199002691 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 264199002692 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 264199002693 Walker A/P-loop; other site 264199002694 ATP binding site [chemical binding]; other site 264199002695 Q-loop/lid; other site 264199002696 ABC transporter signature motif; other site 264199002697 Walker B; other site 264199002698 D-loop; other site 264199002699 H-loop/switch region; other site 264199002700 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 264199002701 PhoU domain; Region: PhoU; pfam01895 264199002702 PhoU domain; Region: PhoU; pfam01895 264199002703 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 264199002704 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 264199002705 Zn binding site [ion binding]; other site 264199002706 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 264199002707 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264199002708 DNA binding site [nucleotide binding] 264199002709 Int/Topo IB signature motif; other site 264199002710 active site 264199002711 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 264199002712 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 264199002713 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 264199002714 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264199002715 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 264199002716 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 264199002717 Transcriptional regulators [Transcription]; Region: PurR; COG1609 264199002718 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264199002719 DNA binding site [nucleotide binding] 264199002720 domain linker motif; other site 264199002721 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 264199002722 putative dimerization interface [polypeptide binding]; other site 264199002723 putative ligand binding site [chemical binding]; other site 264199002724 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 264199002725 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 264199002726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 264199002727 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 264199002728 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 264199002729 Iron permease FTR1 family; Region: FTR1; cl00475 264199002730 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 264199002731 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 264199002732 Imelysin; Region: Peptidase_M75; cl09159 264199002733 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 264199002734 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 264199002735 putative ligand binding residues [chemical binding]; other site 264199002736 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 264199002737 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 264199002738 Walker A/P-loop; other site 264199002739 ATP binding site [chemical binding]; other site 264199002740 Q-loop/lid; other site 264199002741 ABC transporter signature motif; other site 264199002742 Walker B; other site 264199002743 D-loop; other site 264199002744 H-loop/switch region; other site 264199002745 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 264199002746 ABC-ATPase subunit interface; other site 264199002747 dimer interface [polypeptide binding]; other site 264199002748 putative PBP binding regions; other site 264199002749 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 264199002750 ABC-ATPase subunit interface; other site 264199002751 dimer interface [polypeptide binding]; other site 264199002752 putative PBP binding regions; other site 264199002753 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 264199002754 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 264199002755 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 264199002756 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 264199002757 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 264199002758 active site 264199002759 catalytic site [active] 264199002760 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 264199002761 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264199002762 MULE transposase domain; Region: MULE; pfam10551 264199002763 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 264199002764 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 264199002765 nudix motif; other site 264199002766 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 264199002767 active site 264199002768 HIGH motif; other site 264199002769 dimer interface [polypeptide binding]; other site 264199002770 KMSKS motif; other site 264199002771 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264199002772 non-specific DNA binding site [nucleotide binding]; other site 264199002773 salt bridge; other site 264199002774 sequence-specific DNA binding site [nucleotide binding]; other site 264199002775 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 264199002776 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 264199002777 Helix-turn-helix domains; Region: HTH; cl00088 264199002778 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264199002779 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 264199002780 active site 264199002781 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264199002782 E3 interaction surface; other site 264199002783 lipoyl attachment site [posttranslational modification]; other site 264199002784 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 264199002785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199002786 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264199002787 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 264199002788 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 264199002789 E3 interaction surface; other site 264199002790 lipoyl attachment site [posttranslational modification]; other site 264199002791 e3 binding domain; Region: E3_binding; pfam02817 264199002792 e3 binding domain; Region: E3_binding; pfam02817 264199002793 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 264199002794 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 264199002795 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 264199002796 alpha subunit interface [polypeptide binding]; other site 264199002797 TPP binding site [chemical binding]; other site 264199002798 heterodimer interface [polypeptide binding]; other site 264199002799 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 264199002800 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 264199002801 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 264199002802 tetramer interface [polypeptide binding]; other site 264199002803 TPP-binding site [chemical binding]; other site 264199002804 heterodimer interface [polypeptide binding]; other site 264199002805 phosphorylation loop region [posttranslational modification] 264199002806 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 264199002807 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 264199002808 dihydroorotase; Validated; Region: pyrC; PRK09357 264199002809 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264199002810 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 264199002811 active site 264199002812 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 264199002813 ligand binding site [chemical binding]; other site 264199002814 active site 264199002815 UGI interface [polypeptide binding]; other site 264199002816 catalytic site [active] 264199002817 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 264199002818 Cation efflux family; Region: Cation_efflux; cl00316 264199002819 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 264199002820 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 264199002821 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 264199002822 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 264199002823 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 264199002824 active site 264199002825 nucleophile elbow; other site 264199002826 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 264199002827 active site 264199002828 oxyanion hole [active] 264199002829 catalytic triad [active] 264199002830 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 264199002831 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 264199002832 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 264199002833 ATP binding site [chemical binding]; other site 264199002834 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 264199002835 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 264199002836 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 264199002837 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 264199002838 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 264199002839 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 264199002840 Domain of unknown function DUF20; Region: UPF0118; cl00465 264199002841 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264199002842 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264199002843 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 264199002844 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264199002845 VanZ like family; Region: VanZ; cl01971 264199002846 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 264199002847 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264199002848 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 264199002849 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264199002850 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 264199002851 Core-2/I-Branching enzyme; Region: Branch; pfam02485 264199002852 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264199002853 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 264199002854 putative ADP-binding pocket [chemical binding]; other site 264199002855 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 264199002856 O-Antigen ligase; Region: Wzy_C; cl04850 264199002857 Glycosyl transferase family 11; Region: Glyco_transf_11; pfam01531 264199002858 Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488 264199002859 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 264199002860 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 264199002861 trimer interface [polypeptide binding]; other site 264199002862 active site 264199002863 substrate binding site [chemical binding]; other site 264199002864 CoA binding site [chemical binding]; other site 264199002865 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264199002866 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 264199002867 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 264199002868 trimer interface [polypeptide binding]; other site 264199002869 active site 264199002870 substrate binding site [chemical binding]; other site 264199002871 CoA binding site [chemical binding]; other site 264199002872 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264199002873 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl15759 264199002874 Bacterial sugar transferase; Region: Bac_transf; cl00939 264199002875 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 264199002876 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 264199002877 Bacterial sugar transferase; Region: Bac_transf; cl00939 264199002878 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 264199002879 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199002880 Chain length determinant protein; Region: Wzz; cl01623 264199002881 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 264199002882 DNA polymerase processivity factor; Region: DNA_PPF; pfam02916 264199002883 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 264199002884 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 264199002885 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 264199002886 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 264199002887 conserved cys residue [active] 264199002888 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 264199002889 pore gating glutamate residue; other site 264199002890 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 264199002891 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 264199002892 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 264199002893 Sulfatase; Region: Sulfatase; cl10460 264199002894 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 264199002895 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 264199002896 tetramer (dimer of dimers) interface [polypeptide binding]; other site 264199002897 active site 264199002898 dimer interface [polypeptide binding]; other site 264199002899 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 264199002900 Helix-turn-helix domains; Region: HTH; cl00088 264199002901 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264199002902 YSIRK type signal peptide; Region: YSIRK_signal; cl04650 264199002903 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 264199002904 putative uracil binding site [chemical binding]; other site 264199002905 putative active site [active] 264199002906 dipeptidase PepV; Reviewed; Region: PRK07318 264199002907 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 264199002908 active site 264199002909 metal binding site [ion binding]; metal-binding site 264199002910 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 264199002911 active site 1 [active] 264199002912 dimer interface [polypeptide binding]; other site 264199002913 hexamer interface [polypeptide binding]; other site 264199002914 active site 2 [active] 264199002915 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264199002916 Coenzyme A binding pocket [chemical binding]; other site 264199002917 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 264199002918 23S rRNA binding site [nucleotide binding]; other site 264199002919 L21 binding site [polypeptide binding]; other site 264199002920 L13 binding site [polypeptide binding]; other site 264199002921 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 264199002922 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 264199002923 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 264199002924 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 264199002925 cytidylate kinase; Provisional; Region: cmk; PRK00023 264199002926 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 264199002927 CMP-binding site; other site 264199002928 The sites determining sugar specificity; other site 264199002929 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 264199002930 peptidase T; Region: peptidase-T; TIGR01882 264199002931 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 264199002932 metal binding site [ion binding]; metal-binding site 264199002933 dimer interface [polypeptide binding]; other site 264199002934 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 264199002935 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 264199002936 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 264199002937 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 264199002938 binding surface 264199002939 TPR motif; other site 264199002940 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 264199002941 binding surface 264199002942 TPR motif; other site 264199002943 Domain of unknown function DUF20; Region: UPF0118; cl00465 264199002944 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 264199002945 putative active site [active] 264199002946 nucleotide binding site [chemical binding]; other site 264199002947 nudix motif; other site 264199002948 putative metal binding site [ion binding]; other site 264199002949 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 264199002950 FtsX-like permease family; Region: FtsX; pfam02687 264199002951 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 264199002952 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199002953 Walker A/P-loop; other site 264199002954 ATP binding site [chemical binding]; other site 264199002955 Q-loop/lid; other site 264199002956 ABC transporter signature motif; other site 264199002957 Walker B; other site 264199002958 D-loop; other site 264199002959 H-loop/switch region; other site 264199002960 peptide chain release factor 2; Validated; Region: prfB; PRK00578 264199002961 RF-1 domain; Region: RF-1; cl02875 264199002962 RF-1 domain; Region: RF-1; cl02875 264199002963 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 264199002964 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 264199002965 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 264199002966 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264199002967 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 264199002968 dimer interface [polypeptide binding]; other site 264199002969 FMN binding site [chemical binding]; other site 264199002970 NADPH bind site [chemical binding]; other site 264199002971 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 264199002972 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 264199002973 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264199002974 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264199002975 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 264199002976 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 264199002977 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264199002978 Coenzyme A binding pocket [chemical binding]; other site 264199002979 sugar phosphate phosphatase; Provisional; Region: PRK10513 264199002980 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264199002981 active site 264199002982 motif I; other site 264199002983 motif II; other site 264199002984 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264199002985 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264199002986 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264199002987 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 264199002988 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 264199002989 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 264199002990 putative active site [active] 264199002991 heme pocket [chemical binding]; other site 264199002992 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 264199002993 dimer interface [polypeptide binding]; other site 264199002994 phosphorylation site [posttranslational modification] 264199002995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264199002996 ATP binding site [chemical binding]; other site 264199002997 Mg2+ binding site [ion binding]; other site 264199002998 G-X-G motif; other site 264199002999 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264199003000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264199003001 active site 264199003002 phosphorylation site [posttranslational modification] 264199003003 intermolecular recognition site; other site 264199003004 dimerization interface [polypeptide binding]; other site 264199003005 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264199003006 DNA binding site [nucleotide binding] 264199003007 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264199003008 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 264199003009 Walker A/P-loop; other site 264199003010 ATP binding site [chemical binding]; other site 264199003011 Q-loop/lid; other site 264199003012 ABC transporter signature motif; other site 264199003013 Walker B; other site 264199003014 D-loop; other site 264199003015 H-loop/switch region; other site 264199003016 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264199003017 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264199003018 substrate binding pocket [chemical binding]; other site 264199003019 membrane-bound complex binding site; other site 264199003020 hinge residues; other site 264199003021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264199003022 dimer interface [polypeptide binding]; other site 264199003023 conserved gate region; other site 264199003024 putative PBP binding loops; other site 264199003025 ABC-ATPase subunit interface; other site 264199003026 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264199003027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264199003028 dimer interface [polypeptide binding]; other site 264199003029 conserved gate region; other site 264199003030 putative PBP binding loops; other site 264199003031 ABC-ATPase subunit interface; other site 264199003032 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 264199003033 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 264199003034 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 264199003035 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 264199003036 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 264199003037 hinge; other site 264199003038 active site 264199003039 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 264199003040 UDP-glucose 4-epimerase; Region: PLN02240 264199003041 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 264199003042 NAD binding site [chemical binding]; other site 264199003043 homodimer interface [polypeptide binding]; other site 264199003044 active site 264199003045 substrate binding site [chemical binding]; other site 264199003046 S-adenosylmethionine synthetase; Validated; Region: PRK05250 264199003047 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 264199003048 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 264199003049 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 264199003050 Helix-turn-helix domains; Region: HTH; cl00088 264199003051 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 264199003052 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 264199003053 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 264199003054 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 264199003055 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264199003056 Walker A motif; other site 264199003057 ATP binding site [chemical binding]; other site 264199003058 Walker B motif; other site 264199003059 arginine finger; other site 264199003060 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 264199003061 GAF domain; Region: GAF; cl00853 264199003062 IPP transferase; Region: IPPT; cl00403 264199003063 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 264199003064 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 264199003065 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 264199003066 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 264199003067 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 264199003068 putative Cl- selectivity filter; other site 264199003069 putative pore gating glutamate residue; other site 264199003070 Chorismate mutase type II; Region: CM_2; cl00693 264199003071 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 264199003072 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 264199003073 Cl- selectivity filter; other site 264199003074 Cl- binding residues [ion binding]; other site 264199003075 pore gating glutamate residue; other site 264199003076 dimer interface [polypeptide binding]; other site 264199003077 H+/Cl- coupling transport residue; other site 264199003078 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 264199003079 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 264199003080 Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5549 264199003081 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 264199003082 active site 264199003083 Predicted esterase [General function prediction only]; Region: COG0627 264199003084 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264199003085 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 264199003086 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264199003087 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 264199003088 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 264199003089 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199003090 Walker A/P-loop; other site 264199003091 ATP binding site [chemical binding]; other site 264199003092 Q-loop/lid; other site 264199003093 ABC transporter signature motif; other site 264199003094 Walker B; other site 264199003095 D-loop; other site 264199003096 H-loop/switch region; other site 264199003097 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 264199003098 TM-ABC transporter signature motif; other site 264199003099 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 264199003100 zinc binding site [ion binding]; other site 264199003101 putative ligand binding site [chemical binding]; other site 264199003102 pyruvate kinase; Provisional; Region: PRK05826 264199003103 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 264199003104 domain interfaces; other site 264199003105 active site 264199003106 6-phosphofructokinase; Provisional; Region: PRK03202 264199003107 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 264199003108 active site 264199003109 ADP/pyrophosphate binding site [chemical binding]; other site 264199003110 dimerization interface [polypeptide binding]; other site 264199003111 allosteric effector site; other site 264199003112 fructose-1,6-bisphosphate binding site; other site 264199003113 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 264199003114 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 264199003115 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 264199003116 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 264199003117 generic binding surface II; other site 264199003118 generic binding surface I; other site 264199003119 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 264199003120 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 264199003121 substrate binding site [chemical binding]; other site 264199003122 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 264199003123 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 264199003124 substrate binding site [chemical binding]; other site 264199003125 ligand binding site [chemical binding]; other site 264199003126 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 264199003127 tartrate dehydrogenase; Provisional; Region: PRK08194 264199003128 2-isopropylmalate synthase; Validated; Region: PRK00915 264199003129 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 264199003130 active site 264199003131 catalytic residues [active] 264199003132 metal binding site [ion binding]; metal-binding site 264199003133 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 264199003134 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264199003135 catalytic core [active] 264199003136 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 264199003137 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 264199003138 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 264199003139 active site 264199003140 FMN binding site [chemical binding]; other site 264199003141 substrate binding site [chemical binding]; other site 264199003142 catalytic residues [active] 264199003143 homodimer interface [polypeptide binding]; other site 264199003144 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 264199003145 IHF dimer interface [polypeptide binding]; other site 264199003146 IHF - DNA interface [nucleotide binding]; other site 264199003147 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548 264199003148 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 264199003149 active site 264199003150 catalytic triad [active] 264199003151 oxyanion hole [active] 264199003152 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 264199003153 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 264199003154 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 264199003155 Walker A/P-loop; other site 264199003156 ATP binding site [chemical binding]; other site 264199003157 Q-loop/lid; other site 264199003158 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 264199003159 ABC transporter signature motif; other site 264199003160 Walker B; other site 264199003161 D-loop; other site 264199003162 H-loop/switch region; other site 264199003163 Arginine repressor [Transcription]; Region: ArgR; COG1438 264199003164 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 264199003165 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 264199003166 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 264199003167 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 264199003168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 264199003169 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 264199003170 substrate binding pocket [chemical binding]; other site 264199003171 chain length determination region; other site 264199003172 substrate-Mg2+ binding site; other site 264199003173 catalytic residues [active] 264199003174 aspartate-rich region 1; other site 264199003175 active site lid residues [active] 264199003176 aspartate-rich region 2; other site 264199003177 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 264199003178 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 264199003179 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 264199003180 generic binding surface II; other site 264199003181 generic binding surface I; other site 264199003182 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 264199003183 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 264199003184 minor groove reading motif; other site 264199003185 helix-hairpin-helix signature motif; other site 264199003186 substrate binding pocket [chemical binding]; other site 264199003187 active site 264199003188 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 264199003189 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 264199003190 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 264199003191 Homoserine O-succinyltransferase; Region: HTS; pfam04204 264199003192 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 264199003193 proposed active site lysine [active] 264199003194 conserved cys residue [active] 264199003195 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 264199003196 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 264199003197 DHH family; Region: DHH; pfam01368 264199003198 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 264199003199 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 264199003200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199003201 NAD(P) binding site [chemical binding]; other site 264199003202 active site 264199003203 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264199003204 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 264199003205 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 264199003206 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 264199003207 G1 box; other site 264199003208 GTP/Mg2+ binding site [chemical binding]; other site 264199003209 Switch I region; other site 264199003210 G2 box; other site 264199003211 G3 box; other site 264199003212 Switch II region; other site 264199003213 G4 box; other site 264199003214 G5 box; other site 264199003215 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 264199003216 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 264199003217 hypothetical protein; Provisional; Region: PRK07329 264199003218 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 264199003219 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 264199003220 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264199003221 active site 264199003222 motif I; other site 264199003223 motif II; other site 264199003224 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264199003225 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 264199003226 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264199003227 active site 264199003228 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 264199003229 active site 264199003230 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 264199003231 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264199003232 FeS/SAM binding site; other site 264199003233 HemN C-terminal region; Region: HemN_C; pfam06969 264199003234 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 264199003235 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 264199003236 NAD binding site [chemical binding]; other site 264199003237 substrate binding site [chemical binding]; other site 264199003238 homodimer interface [polypeptide binding]; other site 264199003239 active site 264199003240 Cupin domain; Region: Cupin_2; cl09118 264199003241 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 264199003242 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 264199003243 substrate binding site; other site 264199003244 tetramer interface; other site 264199003245 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 264199003246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199003247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199003248 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 264199003249 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 264199003250 Uncharacterized conserved protein [Function unknown]; Region: COG0327 264199003251 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 264199003252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 264199003253 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 264199003254 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 264199003255 active site 264199003256 substrate binding site [chemical binding]; other site 264199003257 metal binding site [ion binding]; metal-binding site 264199003258 YbbR-like protein; Region: YbbR; pfam07949 264199003259 YbbR-like protein; Region: YbbR; pfam07949 264199003260 Uncharacterized conserved protein [Function unknown]; Region: COG1624 264199003261 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 264199003262 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 264199003263 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 264199003264 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 264199003265 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 264199003266 catalytic triad [active] 264199003267 Predicted integral membrane protein [Function unknown]; Region: COG0392 264199003268 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 264199003269 Uncharacterized conserved protein [Function unknown]; Region: COG2898 264199003270 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 264199003271 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 264199003272 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 264199003273 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 264199003274 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199003275 Q-loop/lid; other site 264199003276 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 264199003277 ABC transporter signature motif; other site 264199003278 Walker B; other site 264199003279 D-loop; other site 264199003280 ABC transporter; Region: ABC_tran_2; pfam12848 264199003281 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 264199003282 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 264199003283 Sugar specificity; other site 264199003284 Pyrimidine base specificity; other site 264199003285 ATP-binding site [chemical binding]; other site 264199003286 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199003287 DEAD-like helicases superfamily; Region: DEXDc; smart00487 264199003288 ATP binding site [chemical binding]; other site 264199003289 putative Mg++ binding site [ion binding]; other site 264199003290 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264199003291 nucleotide binding region [chemical binding]; other site 264199003292 ATP-binding site [chemical binding]; other site 264199003293 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 264199003294 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 264199003295 tetrameric interface [polypeptide binding]; other site 264199003296 activator binding site; other site 264199003297 NADP binding site [chemical binding]; other site 264199003298 substrate binding site [chemical binding]; other site 264199003299 catalytic residues [active] 264199003300 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 264199003301 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 264199003302 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 264199003303 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 264199003304 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 264199003305 dimerization domain swap beta strand [polypeptide binding]; other site 264199003306 regulatory protein interface [polypeptide binding]; other site 264199003307 active site 264199003308 regulatory phosphorylation site [posttranslational modification]; other site 264199003309 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 264199003310 isocitrate dehydrogenase; Validated; Region: PRK06451 264199003311 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 264199003312 dimer interface [polypeptide binding]; other site 264199003313 Citrate synthase; Region: Citrate_synt; pfam00285 264199003314 active site 264199003315 citrylCoA binding site [chemical binding]; other site 264199003316 oxalacetate/citrate binding site [chemical binding]; other site 264199003317 coenzyme A binding site [chemical binding]; other site 264199003318 catalytic triad [active] 264199003319 aconitate hydratase; Validated; Region: PRK09277 264199003320 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 264199003321 substrate binding site [chemical binding]; other site 264199003322 ligand binding site [chemical binding]; other site 264199003323 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 264199003324 substrate binding site [chemical binding]; other site 264199003325 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 264199003326 catalytic residues [active] 264199003327 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 264199003328 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 264199003329 Class I ribonucleotide reductase; Region: RNR_I; cd01679 264199003330 active site 264199003331 dimer interface [polypeptide binding]; other site 264199003332 catalytic residues [active] 264199003333 effector binding site; other site 264199003334 R2 peptide binding site; other site 264199003335 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 264199003336 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 264199003337 dimer interface [polypeptide binding]; other site 264199003338 putative radical transfer pathway; other site 264199003339 diiron center [ion binding]; other site 264199003340 tyrosyl radical; other site 264199003341 Helix-turn-helix domains; Region: HTH; cl00088 264199003342 Transposase; Region: DEDD_Tnp_IS110; pfam01548 264199003343 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 264199003344 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 264199003345 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 264199003346 active site 264199003347 metal binding site [ion binding]; metal-binding site 264199003348 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 264199003349 active site 264199003350 catalytic site [active] 264199003351 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 264199003352 DNA gyrase subunit A; Validated; Region: PRK05560 264199003353 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 264199003354 CAP-like domain; other site 264199003355 active site 264199003356 primary dimer interface [polypeptide binding]; other site 264199003357 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264199003358 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264199003359 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264199003360 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264199003361 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264199003362 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 264199003363 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 264199003364 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 264199003365 tetramer (dimer of dimers) interface [polypeptide binding]; other site 264199003366 NAD binding site [chemical binding]; other site 264199003367 dimer interface [polypeptide binding]; other site 264199003368 substrate binding site [chemical binding]; other site 264199003369 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 264199003370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199003371 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 264199003372 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 264199003373 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 264199003374 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199003375 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 264199003376 ABC transporter; Region: ABC_tran_2; pfam12848 264199003377 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 264199003378 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 264199003379 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 264199003380 dimer interface [polypeptide binding]; other site 264199003381 pyridoxal binding site [chemical binding]; other site 264199003382 ATP binding site [chemical binding]; other site 264199003383 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264199003384 DNA-binding site [nucleotide binding]; DNA binding site 264199003385 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264199003386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264199003387 homodimer interface [polypeptide binding]; other site 264199003388 catalytic residue [active] 264199003389 ATP cone domain; Region: ATP-cone; pfam03477 264199003390 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 264199003391 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 264199003392 putative tRNA-binding site [nucleotide binding]; other site 264199003393 B3/4 domain; Region: B3_4; cl11458 264199003394 tRNA synthetase B5 domain; Region: B5; cl08394 264199003395 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 264199003396 dimer interface [polypeptide binding]; other site 264199003397 motif 1; other site 264199003398 motif 3; other site 264199003399 motif 2; other site 264199003400 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 264199003401 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264199003402 Coenzyme A binding pocket [chemical binding]; other site 264199003403 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 264199003404 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 264199003405 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 264199003406 dimer interface [polypeptide binding]; other site 264199003407 motif 1; other site 264199003408 active site 264199003409 motif 2; other site 264199003410 motif 3; other site 264199003411 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 264199003412 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 264199003413 Walker A/P-loop; other site 264199003414 ATP binding site [chemical binding]; other site 264199003415 Q-loop/lid; other site 264199003416 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 264199003417 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 264199003418 dimer interface [polypeptide binding]; other site 264199003419 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 264199003420 ABC transporter signature motif; other site 264199003421 Walker B; other site 264199003422 D-loop; other site 264199003423 H-loop/switch region; other site 264199003424 ribonuclease III; Reviewed; Region: rnc; PRK00102 264199003425 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 264199003426 dimerization interface [polypeptide binding]; other site 264199003427 active site 264199003428 metal binding site [ion binding]; metal-binding site 264199003429 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 264199003430 dsRNA binding site [nucleotide binding]; other site 264199003431 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 264199003432 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 264199003433 dimer interface [polypeptide binding]; other site 264199003434 active site 264199003435 catalytic residue [active] 264199003436 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 264199003437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199003438 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 264199003439 A new structural DNA glycosylase; Region: AlkD_like; cl11434 264199003440 active site 264199003441 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 264199003442 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264199003443 Coenzyme A binding pocket [chemical binding]; other site 264199003444 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264199003445 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 264199003446 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 264199003447 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 264199003448 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 264199003449 putative active site [active] 264199003450 catalytic site [active] 264199003451 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 264199003452 putative active site [active] 264199003453 catalytic site [active] 264199003454 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 264199003455 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 264199003456 GIY-YIG motif/motif A; other site 264199003457 active site 264199003458 catalytic site [active] 264199003459 putative DNA binding site [nucleotide binding]; other site 264199003460 metal binding site [ion binding]; metal-binding site 264199003461 UvrB/uvrC motif; Region: UVR; pfam02151 264199003462 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 264199003463 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 264199003464 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264199003465 active site 264199003466 motif I; other site 264199003467 motif II; other site 264199003468 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 264199003469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264199003470 dimer interface [polypeptide binding]; other site 264199003471 conserved gate region; other site 264199003472 ABC-ATPase subunit interface; other site 264199003473 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199003474 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 264199003475 Walker A/P-loop; other site 264199003476 ATP binding site [chemical binding]; other site 264199003477 Q-loop/lid; other site 264199003478 ABC transporter signature motif; other site 264199003479 Walker B; other site 264199003480 D-loop; other site 264199003481 H-loop/switch region; other site 264199003482 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 264199003483 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 264199003484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264199003485 dimer interface [polypeptide binding]; other site 264199003486 conserved gate region; other site 264199003487 ABC-ATPase subunit interface; other site 264199003488 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 264199003489 active sites [active] 264199003490 tetramer interface [polypeptide binding]; other site 264199003491 Protein of unknown function (DUF917); Region: DUF917; pfam06032 264199003492 urocanate hydratase; Provisional; Region: PRK05414 264199003493 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 264199003494 NAD(P) binding site [chemical binding]; other site 264199003495 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 264199003496 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 264199003497 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 264199003498 putative L-serine binding site [chemical binding]; other site 264199003499 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 264199003500 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 264199003501 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 264199003502 Protein of unknown function (DUF990); Region: DUF990; cl01496 264199003503 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 264199003504 Protein of unknown function (DUF990); Region: DUF990; cl01496 264199003505 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199003506 H-loop/switch region; other site 264199003507 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199003508 ABC transporter signature motif; other site 264199003509 Walker B; other site 264199003510 D-loop; other site 264199003511 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199003512 Walker A/P-loop; other site 264199003513 ATP binding site [chemical binding]; other site 264199003514 Q-loop/lid; other site 264199003515 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264199003516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264199003517 active site 264199003518 phosphorylation site [posttranslational modification] 264199003519 intermolecular recognition site; other site 264199003520 dimerization interface [polypeptide binding]; other site 264199003521 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264199003522 DNA binding residues [nucleotide binding] 264199003523 dimerization interface [polypeptide binding]; other site 264199003524 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 264199003525 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 264199003526 Histidine kinase; Region: HisKA_3; pfam07730 264199003527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 264199003528 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 264199003529 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 264199003530 Walker A/P-loop; other site 264199003531 ATP binding site [chemical binding]; other site 264199003532 Q-loop/lid; other site 264199003533 ABC transporter signature motif; other site 264199003534 Walker B; other site 264199003535 D-loop; other site 264199003536 H-loop/switch region; other site 264199003537 Membrane transport protein; Region: Mem_trans; cl09117 264199003538 bile acid transporter; Region: bass; TIGR00841 264199003539 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 264199003540 active site 264199003541 catalytic motif [active] 264199003542 Zn binding site [ion binding]; other site 264199003543 FtsX-like permease family; Region: FtsX; pfam02687 264199003544 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 264199003545 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 264199003546 Walker A/P-loop; other site 264199003547 ATP binding site [chemical binding]; other site 264199003548 Q-loop/lid; other site 264199003549 ABC transporter signature motif; other site 264199003550 Walker B; other site 264199003551 D-loop; other site 264199003552 H-loop/switch region; other site 264199003553 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 264199003554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264199003555 ATP binding site [chemical binding]; other site 264199003556 Mg2+ binding site [ion binding]; other site 264199003557 G-X-G motif; other site 264199003558 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 264199003559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264199003560 active site 264199003561 phosphorylation site [posttranslational modification] 264199003562 intermolecular recognition site; other site 264199003563 dimerization interface [polypeptide binding]; other site 264199003564 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264199003565 DNA binding site [nucleotide binding] 264199003566 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 264199003567 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 264199003568 Permease family; Region: Xan_ur_permease; cl00967 264199003569 Permease family; Region: Xan_ur_permease; cl00967 264199003570 multidrug efflux protein; Reviewed; Region: PRK01766 264199003571 MatE; Region: MatE; cl10513 264199003572 MatE; Region: MatE; cl10513 264199003573 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 264199003574 SelR domain; Region: SelR; cl00369 264199003575 putative transposase OrfB; Reviewed; Region: PHA02517 264199003576 Integrase core domain; Region: rve; cl01316 264199003577 Helix-turn-helix domains; Region: HTH; cl00088 264199003578 Helix-turn-helix domains; Region: HTH; cl00088 264199003579 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 264199003580 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 264199003581 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 264199003582 CsbD-like; Region: CsbD; cl01888 264199003583 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 264199003584 Amino acid permease; Region: AA_permease; cl00524 264199003585 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 264199003586 dimer interface [polypeptide binding]; other site 264199003587 FMN binding site [chemical binding]; other site 264199003588 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 264199003589 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264199003590 putative metal binding site [ion binding]; other site 264199003591 Predicted transcriptional regulator [Transcription]; Region: COG1959 264199003592 Helix-turn-helix domains; Region: HTH; cl00088 264199003593 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 264199003594 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 264199003595 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 264199003596 dimer interface [polypeptide binding]; other site 264199003597 FMN binding site [chemical binding]; other site 264199003598 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 264199003599 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 264199003600 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 264199003601 active site 264199003602 catalytic tetrad [active] 264199003603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199003604 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 264199003605 T5orf172 domain; Region: T5orf172; cl11176 264199003606 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 264199003607 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264199003608 ATP binding site [chemical binding]; other site 264199003609 putative Mg++ binding site [ion binding]; other site 264199003610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 264199003611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 264199003612 hypothetical protein; Provisional; Region: PRK13663 264199003613 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 264199003614 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 264199003615 DNA binding site [nucleotide binding] 264199003616 Response regulator receiver domain; Region: Response_reg; pfam00072 264199003617 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264199003618 active site 264199003619 phosphorylation site [posttranslational modification] 264199003620 intermolecular recognition site; other site 264199003621 dimerization interface [polypeptide binding]; other site 264199003622 Fibronectin-binding repeat; Region: SSURE; pfam11966 264199003623 DNA polymerase IV; Reviewed; Region: PRK03103 264199003624 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 264199003625 active site 264199003626 DNA binding site [nucleotide binding] 264199003627 LysE type translocator; Region: LysE; cl00565 264199003628 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264199003629 active site 264199003630 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 264199003631 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 264199003632 Ligand binding site; other site 264199003633 metal-binding site 264199003634 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 264199003635 exonuclease SbcC; Region: sbcc; TIGR00618 264199003636 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 264199003637 Walker A/P-loop; other site 264199003638 ATP binding site [chemical binding]; other site 264199003639 Q-loop/lid; other site 264199003640 ABC transporter signature motif; other site 264199003641 Walker B; other site 264199003642 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 264199003643 ABC transporter signature motif; other site 264199003644 Walker B; other site 264199003645 D-loop; other site 264199003646 H-loop/switch region; other site 264199003647 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 264199003648 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 264199003649 active site 264199003650 metal binding site [ion binding]; metal-binding site 264199003651 DNA binding site [nucleotide binding] 264199003652 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 264199003653 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 264199003654 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 264199003655 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 264199003656 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 264199003657 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 264199003658 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 264199003659 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 264199003660 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 264199003661 HPr interaction site; other site 264199003662 glycerol kinase (GK) interaction site [polypeptide binding]; other site 264199003663 active site 264199003664 phosphorylation site [posttranslational modification] 264199003665 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 264199003666 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 264199003667 active site 264199003668 catalytic residues [active] 264199003669 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 264199003670 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 264199003671 NAD binding site [chemical binding]; other site 264199003672 homodimer interface [polypeptide binding]; other site 264199003673 active site 264199003674 substrate binding site [chemical binding]; other site 264199003675 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 264199003676 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 264199003677 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 264199003678 galactokinase; Provisional; Region: PRK05322 264199003679 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 264199003680 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 264199003681 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 264199003682 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 264199003683 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264199003684 DNA binding site [nucleotide binding] 264199003685 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 264199003686 putative dimerization interface [polypeptide binding]; other site 264199003687 putative ligand binding site [chemical binding]; other site 264199003688 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 264199003689 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 264199003690 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 264199003691 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199003692 Walker B; other site 264199003693 D-loop; other site 264199003694 H-loop/switch region; other site 264199003695 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199003696 ATP binding site [chemical binding]; other site 264199003697 Q-loop/lid; other site 264199003698 ABC transporter signature motif; other site 264199003699 Walker B; other site 264199003700 D-loop; other site 264199003701 H-loop/switch region; other site 264199003702 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 264199003703 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 264199003704 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 264199003705 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 264199003706 Helix-turn-helix domains; Region: HTH; cl00088 264199003707 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264199003708 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 264199003709 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 264199003710 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199003711 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 264199003712 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 264199003713 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199003714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199003715 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 264199003716 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 264199003717 RimM N-terminal domain; Region: RimM; pfam01782 264199003718 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 264199003719 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 264199003720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264199003721 active site 264199003722 phosphorylation site [posttranslational modification] 264199003723 intermolecular recognition site; other site 264199003724 dimerization interface [polypeptide binding]; other site 264199003725 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 264199003726 DNA binding residues [nucleotide binding] 264199003727 dimerization interface [polypeptide binding]; other site 264199003728 Histidine kinase; Region: HisKA_3; pfam07730 264199003729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264199003730 ATP binding site [chemical binding]; other site 264199003731 Mg2+ binding site [ion binding]; other site 264199003732 G-X-G motif; other site 264199003733 Predicted membrane protein (DUF2154); Region: DUF2154; cl12089 264199003734 Ion channel; Region: Ion_trans_2; cl11596 264199003735 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 264199003736 Catalytic domain of Protein Kinases; Region: PKc; cd00180 264199003737 active site 264199003738 ATP binding site [chemical binding]; other site 264199003739 substrate binding site [chemical binding]; other site 264199003740 activation loop (A-loop); other site 264199003741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 264199003742 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 264199003743 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 264199003744 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 264199003745 active site 264199003746 16S rRNA methyltransferase B; Provisional; Region: PRK14902 264199003747 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 264199003748 putative RNA binding site [nucleotide binding]; other site 264199003749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 264199003750 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 264199003751 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 264199003752 putative active site [active] 264199003753 substrate binding site [chemical binding]; other site 264199003754 putative cosubstrate binding site; other site 264199003755 catalytic site [active] 264199003756 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 264199003757 substrate binding site [chemical binding]; other site 264199003758 primosome assembly protein PriA; Validated; Region: PRK05580 264199003759 primosome assembly protein PriA; Validated; Region: PRK05580 264199003760 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264199003761 ATP binding site [chemical binding]; other site 264199003762 putative Mg++ binding site [ion binding]; other site 264199003763 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264199003764 nucleotide binding region [chemical binding]; other site 264199003765 ATP-binding site [chemical binding]; other site 264199003766 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 264199003767 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 264199003768 catalytic site [active] 264199003769 G-X2-G-X-G-K; other site 264199003770 acetyl-CoA synthetase; Provisional; Region: PTZ00237 264199003771 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 264199003772 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 264199003773 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 264199003774 P loop; other site 264199003775 GTP binding site [chemical binding]; other site 264199003776 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264199003777 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 264199003778 active site 264199003779 motif I; other site 264199003780 motif II; other site 264199003781 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264199003782 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264199003783 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 264199003784 active site 264199003785 motif I; other site 264199003786 motif II; other site 264199003787 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264199003788 Predicted transcriptional regulators [Transcription]; Region: COG1725 264199003789 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264199003790 DNA-binding site [nucleotide binding]; DNA binding site 264199003791 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 264199003792 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 264199003793 Walker A/P-loop; other site 264199003794 ATP binding site [chemical binding]; other site 264199003795 Q-loop/lid; other site 264199003796 ABC transporter signature motif; other site 264199003797 Walker B; other site 264199003798 D-loop; other site 264199003799 H-loop/switch region; other site 264199003800 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 264199003801 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 264199003802 Walker A/P-loop; other site 264199003803 ATP binding site [chemical binding]; other site 264199003804 Q-loop/lid; other site 264199003805 ABC transporter signature motif; other site 264199003806 Walker B; other site 264199003807 D-loop; other site 264199003808 H-loop/switch region; other site 264199003809 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264199003810 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 264199003811 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 264199003812 Walker A/P-loop; other site 264199003813 ATP binding site [chemical binding]; other site 264199003814 Q-loop/lid; other site 264199003815 ABC transporter signature motif; other site 264199003816 Walker B; other site 264199003817 D-loop; other site 264199003818 H-loop/switch region; other site 264199003819 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264199003820 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 264199003821 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 264199003822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264199003823 dimer interface [polypeptide binding]; other site 264199003824 conserved gate region; other site 264199003825 putative PBP binding loops; other site 264199003826 ABC-ATPase subunit interface; other site 264199003827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264199003828 dimer interface [polypeptide binding]; other site 264199003829 conserved gate region; other site 264199003830 putative PBP binding loops; other site 264199003831 ABC-ATPase subunit interface; other site 264199003832 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 264199003833 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 264199003834 peptide binding site [polypeptide binding]; other site 264199003835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 264199003836 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264199003837 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 264199003838 peptide binding site [polypeptide binding]; other site 264199003839 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 264199003840 Integrase core domain; Region: rve_3; cl15866 264199003841 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 264199003842 ABC transporter signature motif; other site 264199003843 Walker B; other site 264199003844 D-loop; other site 264199003845 H-loop/switch region; other site 264199003846 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 264199003847 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 264199003848 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 264199003849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 264199003850 putative substrate translocation pore; other site 264199003851 Integrase core domain; Region: rve; cl01316 264199003852 putative transposase OrfB; Reviewed; Region: PHA02517 264199003853 Helix-turn-helix domains; Region: HTH; cl00088 264199003854 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 264199003855 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 264199003856 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 264199003857 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 264199003858 active site 264199003859 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 264199003860 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 264199003861 synthetase active site [active] 264199003862 NTP binding site [chemical binding]; other site 264199003863 metal binding site [ion binding]; metal-binding site 264199003864 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 264199003865 putative active site [active] 264199003866 putative metal binding residues [ion binding]; other site 264199003867 signature motif; other site 264199003868 putative triphosphate binding site [ion binding]; other site 264199003869 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 264199003870 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 264199003871 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264199003872 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 264199003873 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264199003874 catalytic residue [active] 264199003875 Domain of unknown function (DUF1831); Region: DUF1831; pfam08866 264199003876 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 264199003877 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 264199003878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199003879 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 264199003880 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 264199003881 catalytic triad [active] 264199003882 hypothetical protein; Reviewed; Region: PRK00024 264199003883 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 264199003884 MPN+ (JAMM) motif; other site 264199003885 Zinc-binding site [ion binding]; other site 264199003886 Rhamnan synthesis protein F; Region: RgpF; cl01529 264199003887 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264199003888 active site 264199003889 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 264199003890 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 264199003891 Walker A/P-loop; other site 264199003892 ATP binding site [chemical binding]; other site 264199003893 Q-loop/lid; other site 264199003894 ABC transporter signature motif; other site 264199003895 Walker B; other site 264199003896 D-loop; other site 264199003897 H-loop/switch region; other site 264199003898 ABC-2 type transporter; Region: ABC2_membrane; cl11417 264199003899 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 264199003900 Probable Catalytic site; other site 264199003901 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 264199003902 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 264199003903 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 264199003904 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 264199003905 active site 264199003906 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 264199003907 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 264199003908 Ligand binding site; other site 264199003909 Putative Catalytic site; other site 264199003910 DXD motif; other site 264199003911 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 264199003912 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 264199003913 NADP binding site [chemical binding]; other site 264199003914 active site 264199003915 putative substrate binding site [chemical binding]; other site 264199003916 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 264199003917 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 264199003918 Ligand binding site; other site 264199003919 Putative Catalytic site; other site 264199003920 DXD motif; other site 264199003921 Predicted membrane protein (DUF2142); Region: DUF2142; cl01937 264199003922 Domain of unknown function DUF59; Region: DUF59; cl00941 264199003923 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 264199003924 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 264199003925 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 264199003926 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 264199003927 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 264199003928 DNA binding residues [nucleotide binding] 264199003929 DNA primase; Validated; Region: dnaG; PRK05667 264199003930 CHC2 zinc finger; Region: zf-CHC2; cl15369 264199003931 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 264199003932 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 264199003933 active site 264199003934 metal binding site [ion binding]; metal-binding site 264199003935 interdomain interaction site; other site 264199003936 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 264199003937 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264199003938 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264199003939 substrate binding pocket [chemical binding]; other site 264199003940 membrane-bound complex binding site; other site 264199003941 hinge residues; other site 264199003942 transaminase; Validated; Region: PRK07324 264199003943 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264199003944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264199003945 homodimer interface [polypeptide binding]; other site 264199003946 catalytic residue [active] 264199003947 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264199003948 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264199003949 substrate binding pocket [chemical binding]; other site 264199003950 membrane-bound complex binding site; other site 264199003951 hinge residues; other site 264199003952 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264199003953 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264199003954 substrate binding pocket [chemical binding]; other site 264199003955 membrane-bound complex binding site; other site 264199003956 hinge residues; other site 264199003957 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 264199003958 putative active site [active] 264199003959 nucleotide binding site [chemical binding]; other site 264199003960 nudix motif; other site 264199003961 putative metal binding site [ion binding]; other site 264199003962 excinuclease ABC subunit B; Provisional; Region: PRK05298 264199003963 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264199003964 ATP binding site [chemical binding]; other site 264199003965 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264199003966 nucleotide binding region [chemical binding]; other site 264199003967 ATP-binding site [chemical binding]; other site 264199003968 Ultra-violet resistance protein B; Region: UvrB; pfam12344 264199003969 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 264199003970 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264199003971 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264199003972 substrate binding pocket [chemical binding]; other site 264199003973 membrane-bound complex binding site; other site 264199003974 hinge residues; other site 264199003975 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264199003976 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264199003977 substrate binding pocket [chemical binding]; other site 264199003978 membrane-bound complex binding site; other site 264199003979 hinge residues; other site 264199003980 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264199003981 dimer interface [polypeptide binding]; other site 264199003982 conserved gate region; other site 264199003983 putative PBP binding loops; other site 264199003984 ABC-ATPase subunit interface; other site 264199003985 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264199003986 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 264199003987 Walker A/P-loop; other site 264199003988 ATP binding site [chemical binding]; other site 264199003989 Q-loop/lid; other site 264199003990 ABC transporter signature motif; other site 264199003991 Walker B; other site 264199003992 D-loop; other site 264199003993 H-loop/switch region; other site 264199003994 GTPase CgtA; Reviewed; Region: obgE; PRK12297 264199003995 GTP1/OBG; Region: GTP1_OBG; pfam01018 264199003996 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 264199003997 G1 box; other site 264199003998 GTP/Mg2+ binding site [chemical binding]; other site 264199003999 Switch I region; other site 264199004000 G2 box; other site 264199004001 G3 box; other site 264199004002 Switch II region; other site 264199004003 G4 box; other site 264199004004 G5 box; other site 264199004005 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 264199004006 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 264199004007 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264199004008 RNA binding surface [nucleotide binding]; other site 264199004009 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 264199004010 active site 264199004011 uracil binding [chemical binding]; other site 264199004012 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 264199004013 Predicted transcriptional regulator [Transcription]; Region: COG5340 264199004014 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 264199004015 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264199004016 non-specific DNA binding site [nucleotide binding]; other site 264199004017 salt bridge; other site 264199004018 sequence-specific DNA binding site [nucleotide binding]; other site 264199004019 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 264199004020 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264199004021 FeS/SAM binding site; other site 264199004022 Radical SAM superfamily; Region: Radical_SAM; pfam04055 264199004023 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; cl14869 264199004024 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264199004025 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 264199004026 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 264199004027 Walker A/P-loop; other site 264199004028 ATP binding site [chemical binding]; other site 264199004029 Q-loop/lid; other site 264199004030 ABC transporter signature motif; other site 264199004031 Walker B; other site 264199004032 D-loop; other site 264199004033 H-loop/switch region; other site 264199004034 Domain of unknown function (DUF4299); Region: DUF4299; pfam14132 264199004035 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 264199004036 CoenzymeA binding site [chemical binding]; other site 264199004037 subunit interaction site [polypeptide binding]; other site 264199004038 PHB binding site; other site 264199004039 EamA-like transporter family; Region: EamA; cl01037 264199004040 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 264199004041 EamA-like transporter family; Region: EamA; cl01037 264199004042 phosphoserine phosphatase SerB; Region: serB; TIGR00338 264199004043 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264199004044 motif II; other site 264199004045 septation ring formation regulator EzrA; Provisional; Region: PRK04778 264199004046 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 264199004047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 264199004048 Mg2+ binding site [ion binding]; other site 264199004049 G-X-G motif; other site 264199004050 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 264199004051 anchoring element; other site 264199004052 dimer interface [polypeptide binding]; other site 264199004053 ATP binding site [chemical binding]; other site 264199004054 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 264199004055 active site 264199004056 putative metal-binding site [ion binding]; other site 264199004057 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 264199004058 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 264199004059 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264199004060 motif II; other site 264199004061 LrgB-like family; Region: LrgB; cl00596 264199004062 LrgA family; Region: LrgA; cl00608 264199004063 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 264199004064 ArsC family; Region: ArsC; pfam03960 264199004065 putative ArsC-like catalytic residues; other site 264199004066 putative TRX-like catalytic residues [active] 264199004067 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 264199004068 DNA binding site [nucleotide binding] 264199004069 active site 264199004070 glyoxylate reductase; Reviewed; Region: PRK13243 264199004071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199004072 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 264199004073 L-serine binding site [chemical binding]; other site 264199004074 ACT domain interface; other site 264199004075 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 264199004076 Aminotransferase class-V; Region: Aminotran_5; pfam00266 264199004077 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 264199004078 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 264199004079 catalytic residue [active] 264199004080 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 264199004081 N-acetylmannosamine kinase; Provisional; Region: PRK05082 264199004082 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 264199004083 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 264199004084 dimer interface [polypeptide binding]; other site 264199004085 active site 264199004086 metal binding site [ion binding]; metal-binding site 264199004087 glutathione binding site [chemical binding]; other site 264199004088 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 264199004089 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 264199004090 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 264199004091 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 264199004092 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 264199004093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264199004094 dimer interface [polypeptide binding]; other site 264199004095 conserved gate region; other site 264199004096 putative PBP binding loops; other site 264199004097 ABC-ATPase subunit interface; other site 264199004098 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 264199004099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264199004100 dimer interface [polypeptide binding]; other site 264199004101 conserved gate region; other site 264199004102 putative PBP binding loops; other site 264199004103 ABC-ATPase subunit interface; other site 264199004104 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 264199004105 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues required...; Region: ABC_PotA_N; cd03300 264199004106 Walker A/P-loop; other site 264199004107 ATP binding site [chemical binding]; other site 264199004108 Q-loop/lid; other site 264199004109 ABC transporter signature motif; other site 264199004110 Walker B; other site 264199004111 D-loop; other site 264199004112 H-loop/switch region; other site 264199004113 TOBE domain; Region: TOBE_2; cl01440 264199004114 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 264199004115 FAD binding domain; Region: FAD_binding_4; pfam01565 264199004116 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 264199004117 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 264199004118 catalytic center binding site [active] 264199004119 ATP binding site [chemical binding]; other site 264199004120 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 264199004121 homooctamer interface [polypeptide binding]; other site 264199004122 active site 264199004123 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 264199004124 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 264199004125 active site 264199004126 Na/Ca binding site [ion binding]; other site 264199004127 catalytic site [active] 264199004128 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 264199004129 dihydropteroate synthase; Region: DHPS; TIGR01496 264199004130 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 264199004131 substrate binding pocket [chemical binding]; other site 264199004132 dimer interface [polypeptide binding]; other site 264199004133 inhibitor binding site; inhibition site 264199004134 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 264199004135 homodecamer interface [polypeptide binding]; other site 264199004136 GTP cyclohydrolase I; Provisional; Region: PLN03044 264199004137 active site 264199004138 putative catalytic site residues [active] 264199004139 zinc binding site [ion binding]; other site 264199004140 GTP-CH-I/GFRP interaction surface; other site 264199004141 Amino acid permease; Region: AA_permease; cl00524 264199004142 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 264199004143 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 264199004144 hypothetical protein; Provisional; Region: PRK00468; cl00794 264199004145 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 264199004146 Domain of unknown function (DUF1971); Region: DUF1971; cl01451 264199004147 tellurite resistance protein TehB; Provisional; Region: PRK12335 264199004148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264199004149 S-adenosylmethionine binding site [chemical binding]; other site 264199004150 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 264199004151 active site 264199004152 DNA binding site [nucleotide binding] 264199004153 putative phosphate binding site [ion binding]; other site 264199004154 putative catalytic site [active] 264199004155 metal binding site A [ion binding]; metal-binding site 264199004156 AP binding site [nucleotide binding]; other site 264199004157 metal binding site B [ion binding]; metal-binding site 264199004158 QueT transporter; Region: QueT; cl01932 264199004159 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 264199004160 putative lipid kinase; Reviewed; Region: PRK13055 264199004161 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 264199004162 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 264199004163 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 264199004164 nucleotide binding pocket [chemical binding]; other site 264199004165 K-X-D-G motif; other site 264199004166 catalytic site [active] 264199004167 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 264199004168 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 264199004169 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 264199004170 Dimer interface [polypeptide binding]; other site 264199004171 BRCT sequence motif; other site 264199004172 QueT transporter; Region: QueT; cl01932 264199004173 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 264199004174 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 264199004175 active site 264199004176 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 264199004177 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264199004178 DNA-binding site [nucleotide binding]; DNA binding site 264199004179 DRTGG domain; Region: DRTGG; cl12147 264199004180 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 264199004181 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 264199004182 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264199004183 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 264199004184 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 264199004185 hinge; other site 264199004186 active site 264199004187 Competence protein; Region: Competence; cl00471 264199004188 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264199004189 SLBB domain; Region: SLBB; pfam10531 264199004190 comEA protein; Region: comE; TIGR01259 264199004191 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 264199004192 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 264199004193 putative acyl-acceptor binding pocket; other site 264199004194 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 264199004195 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 264199004196 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 264199004197 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264199004198 S-adenosylmethionine binding site [chemical binding]; other site 264199004199 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 264199004200 GIY-YIG motif/motif A; other site 264199004201 putative active site [active] 264199004202 putative metal binding site [ion binding]; other site 264199004203 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 264199004204 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264199004205 ATP binding site [chemical binding]; other site 264199004206 Mg++ binding site [ion binding]; other site 264199004207 motif III; other site 264199004208 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264199004209 nucleotide binding region [chemical binding]; other site 264199004210 ATP-binding site [chemical binding]; other site 264199004211 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 264199004212 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 264199004213 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 264199004214 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264199004215 non-specific DNA binding site [nucleotide binding]; other site 264199004216 salt bridge; other site 264199004217 sequence-specific DNA binding site [nucleotide binding]; other site 264199004218 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 264199004219 H+ Antiporter protein; Region: 2A0121; TIGR00900 264199004220 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 264199004221 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 264199004222 G1 box; other site 264199004223 putative GEF interaction site [polypeptide binding]; other site 264199004224 GTP/Mg2+ binding site [chemical binding]; other site 264199004225 Switch I region; other site 264199004226 G2 box; other site 264199004227 G3 box; other site 264199004228 Switch II region; other site 264199004229 G4 box; other site 264199004230 G5 box; other site 264199004231 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 264199004232 Predicted integral membrane protein [Function unknown]; Region: COG5522; cl02331 264199004233 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 264199004234 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 264199004235 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 264199004236 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 264199004237 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 264199004238 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264199004239 substrate binding pocket [chemical binding]; other site 264199004240 membrane-bound complex binding site; other site 264199004241 hinge residues; other site 264199004242 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264199004243 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 264199004244 Walker A/P-loop; other site 264199004245 ATP binding site [chemical binding]; other site 264199004246 Q-loop/lid; other site 264199004247 ABC transporter signature motif; other site 264199004248 Walker B; other site 264199004249 D-loop; other site 264199004250 H-loop/switch region; other site 264199004251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264199004252 dimer interface [polypeptide binding]; other site 264199004253 conserved gate region; other site 264199004254 putative PBP binding loops; other site 264199004255 ABC-ATPase subunit interface; other site 264199004256 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 264199004257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264199004258 dimer interface [polypeptide binding]; other site 264199004259 conserved gate region; other site 264199004260 putative PBP binding loops; other site 264199004261 ABC-ATPase subunit interface; other site 264199004262 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 264199004263 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 264199004264 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 264199004265 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264199004266 metal-binding site [ion binding] 264199004267 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 264199004268 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 264199004269 metal-binding site [ion binding] 264199004270 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264199004271 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264199004272 Helix-turn-helix domains; Region: HTH; cl00088 264199004273 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 264199004274 substrate binding site [chemical binding]; other site 264199004275 active site 264199004276 catalytic residues [active] 264199004277 heterodimer interface [polypeptide binding]; other site 264199004278 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 264199004279 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 264199004280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264199004281 catalytic residue [active] 264199004282 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 264199004283 active site 264199004284 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 264199004285 active site 264199004286 ribulose/triose binding site [chemical binding]; other site 264199004287 phosphate binding site [ion binding]; other site 264199004288 substrate (anthranilate) binding pocket [chemical binding]; other site 264199004289 product (indole) binding pocket [chemical binding]; other site 264199004290 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 264199004291 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 264199004292 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 264199004293 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 264199004294 Glutamine amidotransferase class-I; Region: GATase; pfam00117 264199004295 glutamine binding [chemical binding]; other site 264199004296 catalytic triad [active] 264199004297 anthranilate synthase component I; Provisional; Region: PRK13570 264199004298 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 264199004299 chorismate binding enzyme; Region: Chorismate_bind; cl10555 264199004300 Chorismate mutase type II; Region: CM_2; cl00693 264199004301 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 264199004302 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 264199004303 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 264199004304 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 264199004305 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 264199004306 DNA binding residues [nucleotide binding] 264199004307 dimer interface [polypeptide binding]; other site 264199004308 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 264199004309 active site 264199004310 substrate binding site [chemical binding]; other site 264199004311 catalytic site [active] 264199004312 Helix-turn-helix domains; Region: HTH; cl00088 264199004313 phosphodiesterase; Provisional; Region: PRK12704 264199004314 Domain of unknown function DUF59; Region: DUF59; cl00941 264199004315 6-phosphogluconate dehydratase; Region: edd; TIGR01196 264199004316 Dehydratase family; Region: ILVD_EDD; cl00340 264199004317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199004318 flavoprotein, HI0933 family; Region: TIGR00275 264199004319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264199004320 S-adenosylmethionine binding site [chemical binding]; other site 264199004321 Phosphotransferase enzyme family; Region: APH; pfam01636 264199004322 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 264199004323 active site 264199004324 ATP binding site [chemical binding]; other site 264199004325 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 264199004326 substrate binding site [chemical binding]; other site 264199004327 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 264199004328 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 264199004329 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 264199004330 Walker A/P-loop; other site 264199004331 ATP binding site [chemical binding]; other site 264199004332 Q-loop/lid; other site 264199004333 ABC transporter signature motif; other site 264199004334 Walker B; other site 264199004335 D-loop; other site 264199004336 H-loop/switch region; other site 264199004337 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 264199004338 HIT family signature motif; other site 264199004339 catalytic residue [active] 264199004340 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 264199004341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264199004342 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 264199004343 Walker A motif; other site 264199004344 ATP binding site [chemical binding]; other site 264199004345 Walker B motif; other site 264199004346 arginine finger; other site 264199004347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264199004348 Walker A motif; other site 264199004349 ATP binding site [chemical binding]; other site 264199004350 Walker B motif; other site 264199004351 arginine finger; other site 264199004352 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 264199004353 hypothetical protein; Provisional; Region: PRK13670 264199004354 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 264199004355 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 264199004356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264199004357 S-adenosylmethionine binding site [chemical binding]; other site 264199004358 Domain of unknown function DUF143; Region: DUF143; cl00519 264199004359 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 264199004360 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 264199004361 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 264199004362 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 264199004363 active site 264199004364 (T/H)XGH motif; other site 264199004365 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663 264199004366 GTPase YqeH; Provisional; Region: PRK13796 264199004367 YqeH. YqeH is an essential GTP-binding protein. Depletion of YqeH induces an excess initiation of DNA replication, suggesting that it negatively controls initiation of chromosome replication. The YqeH subfamily is common in eukaryotes and sporadically...; Region: YqeH; cd01855 264199004368 GTP/Mg2+ binding site [chemical binding]; other site 264199004369 G4 box; other site 264199004370 G5 box; other site 264199004371 G1 box; other site 264199004372 Switch I region; other site 264199004373 G2 box; other site 264199004374 G3 box; other site 264199004375 Switch II region; other site 264199004376 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264199004377 active site 264199004378 motif I; other site 264199004379 motif II; other site 264199004380 EamA-like transporter family; Region: EamA; cl01037 264199004381 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 264199004382 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 264199004383 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 264199004384 GatB domain; Region: GatB_Yqey; cl11497 264199004385 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 264199004386 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 264199004387 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 264199004388 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 264199004389 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 264199004390 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 264199004391 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 264199004392 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 264199004393 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 264199004394 Isochorismatase family; Region: Isochorismatase; pfam00857 264199004395 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 264199004396 catalytic triad [active] 264199004397 conserved cis-peptide bond; other site 264199004398 transcriptional repressor CodY; Validated; Region: PRK04158 264199004399 CodY GAF-like domain; Region: CodY; pfam06018 264199004400 Helix-turn-helix domains; Region: HTH; cl00088 264199004401 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 264199004402 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 264199004403 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264199004404 homodimer interface [polypeptide binding]; other site 264199004405 catalytic residue [active] 264199004406 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 264199004407 Ligand Binding Site [chemical binding]; other site 264199004408 Integrase core domain; Region: rve; cl01316 264199004409 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 264199004410 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264199004411 FeS/SAM binding site; other site 264199004412 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 264199004413 Domain of unknown function DUF21; Region: DUF21; pfam01595 264199004414 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 264199004415 Transporter associated domain; Region: CorC_HlyC; cl08393 264199004416 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 264199004417 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199004418 Walker A/P-loop; other site 264199004419 ATP binding site [chemical binding]; other site 264199004420 Q-loop/lid; other site 264199004421 ABC transporter signature motif; other site 264199004422 Walker B; other site 264199004423 D-loop; other site 264199004424 H-loop/switch region; other site 264199004425 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 264199004426 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 264199004427 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 264199004428 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 264199004429 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 264199004430 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 264199004431 protein binding site [polypeptide binding]; other site 264199004432 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 264199004433 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 264199004434 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 264199004435 active site 264199004436 (T/H)XGH motif; other site 264199004437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264199004438 S-adenosylmethionine binding site [chemical binding]; other site 264199004439 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199004440 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 264199004441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199004442 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 264199004443 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 264199004444 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 264199004445 Walker A/P-loop; other site 264199004446 ATP binding site [chemical binding]; other site 264199004447 Q-loop/lid; other site 264199004448 ABC transporter signature motif; other site 264199004449 Walker B; other site 264199004450 D-loop; other site 264199004451 H-loop/switch region; other site 264199004452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 264199004453 dimer interface [polypeptide binding]; other site 264199004454 conserved gate region; other site 264199004455 putative PBP binding loops; other site 264199004456 ABC-ATPase subunit interface; other site 264199004457 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 264199004458 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 264199004459 substrate binding pocket [chemical binding]; other site 264199004460 membrane-bound complex binding site; other site 264199004461 hinge residues; other site 264199004462 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 264199004463 active site 264199004464 DNA polymerase IV; Validated; Region: PRK02406 264199004465 DNA binding site [nucleotide binding] 264199004466 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 264199004467 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 264199004468 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 264199004469 active site 264199004470 zinc binding site [ion binding]; other site 264199004471 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264199004472 Coenzyme A binding pocket [chemical binding]; other site 264199004473 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 264199004474 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 264199004475 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 264199004476 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 264199004477 DNA binding site [nucleotide binding] 264199004478 Int/Topo IB signature motif; other site 264199004479 active site 264199004480 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cl00630 264199004481 putative active site [active] 264199004482 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 264199004483 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 264199004484 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 264199004485 Walker A/P-loop; other site 264199004486 ATP binding site [chemical binding]; other site 264199004487 Q-loop/lid; other site 264199004488 ABC transporter signature motif; other site 264199004489 Walker B; other site 264199004490 D-loop; other site 264199004491 H-loop/switch region; other site 264199004492 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264199004493 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 264199004494 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 264199004495 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 264199004496 amphipathic channel; other site 264199004497 Asn-Pro-Ala signature motifs; other site 264199004498 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 264199004499 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; cl07696 264199004500 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 264199004501 Enterocin A Immunity; Region: EntA_Immun; pfam08951 264199004502 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 264199004503 catalytic residues [active] 264199004504 Helix-turn-helix domains; Region: HTH; cl00088 264199004505 Helix-turn-helix domains; Region: HTH; cl00088 264199004506 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264199004507 Helix-turn-helix domains; Region: HTH; cl00088 264199004508 putative transposase OrfB; Reviewed; Region: PHA02517 264199004509 Integrase core domain; Region: rve; cl01316 264199004510 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 264199004511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 264199004512 active site 264199004513 phosphorylation site [posttranslational modification] 264199004514 intermolecular recognition site; other site 264199004515 dimerization interface [polypeptide binding]; other site 264199004516 LytTr DNA-binding domain; Region: LytTR; cl04498 264199004517 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 264199004518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 264199004519 COMC family; Region: ComC; pfam03047 264199004520 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 264199004521 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 264199004522 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39B; cd02418 264199004523 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 264199004524 putative active site [active] 264199004525 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 264199004526 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199004527 Walker A/P-loop; other site 264199004528 ATP binding site [chemical binding]; other site 264199004529 Q-loop/lid; other site 264199004530 ABC transporter signature motif; other site 264199004531 Walker B; other site 264199004532 D-loop; other site 264199004533 H-loop/switch region; other site 264199004534 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264199004535 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 264199004536 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 264199004537 Walker A/P-loop; other site 264199004538 ATP binding site [chemical binding]; other site 264199004539 Q-loop/lid; other site 264199004540 ABC transporter signature motif; other site 264199004541 Walker B; other site 264199004542 D-loop; other site 264199004543 H-loop/switch region; other site 264199004544 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 264199004545 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 264199004546 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199004547 Walker A/P-loop; other site 264199004548 ATP binding site [chemical binding]; other site 264199004549 Q-loop/lid; other site 264199004550 ABC transporter signature motif; other site 264199004551 Walker B; other site 264199004552 D-loop; other site 264199004553 H-loop/switch region; other site 264199004554 VanZ like family; Region: VanZ; cl01971 264199004555 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 264199004556 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264199004557 FeS/SAM binding site; other site 264199004558 Protein of unknown function (DUF1027); Region: DUF1027; cl09961 264199004559 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 264199004560 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 264199004561 active site 264199004562 metal binding site [ion binding]; metal-binding site 264199004563 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 264199004564 DEAD-like helicases superfamily; Region: DEXDc; smart00487 264199004565 ATP binding site [chemical binding]; other site 264199004566 Mg++ binding site [ion binding]; other site 264199004567 motif III; other site 264199004568 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264199004569 nucleotide binding region [chemical binding]; other site 264199004570 ATP-binding site [chemical binding]; other site 264199004571 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 264199004572 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 264199004573 Mg++ binding site [ion binding]; other site 264199004574 putative catalytic motif [active] 264199004575 putative substrate binding site [chemical binding]; other site 264199004576 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 264199004577 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 264199004578 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264199004579 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 264199004580 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 264199004581 Septum formation initiator; Region: DivIC; cl11433 264199004582 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 264199004583 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 264199004584 Protein of unknown function (DUF805); Region: DUF805; cl01224 264199004585 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 264199004586 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 264199004587 putative catalytic cysteine [active] 264199004588 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 264199004589 nucleotide binding site [chemical binding]; other site 264199004590 homotetrameric interface [polypeptide binding]; other site 264199004591 putative phosphate binding site [ion binding]; other site 264199004592 putative allosteric binding site; other site 264199004593 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199004594 ABC transporter signature motif; other site 264199004595 Walker B; other site 264199004596 D-loop; other site 264199004597 H-loop/switch region; other site 264199004598 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199004599 Walker A/P-loop; other site 264199004600 ATP binding site [chemical binding]; other site 264199004601 Q-loop/lid; other site 264199004602 Protein of unknown function (DUF554); Region: DUF554; cl00784 264199004603 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 264199004604 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199004605 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199004606 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 264199004607 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 264199004608 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 264199004609 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264199004610 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 264199004611 active site 264199004612 motif I; other site 264199004613 motif II; other site 264199004614 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264199004615 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 264199004616 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 264199004617 active site 264199004618 homotetramer interface [polypeptide binding]; other site 264199004619 homodimer interface [polypeptide binding]; other site 264199004620 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 264199004621 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 264199004622 generic binding surface II; other site 264199004623 ssDNA binding site; other site 264199004624 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 264199004625 ATP binding site [chemical binding]; other site 264199004626 putative Mg++ binding site [ion binding]; other site 264199004627 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264199004628 nucleotide binding region [chemical binding]; other site 264199004629 ATP-binding site [chemical binding]; other site 264199004630 alanine racemase; Reviewed; Region: alr; PRK00053 264199004631 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 264199004632 active site 264199004633 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 264199004634 dimer interface [polypeptide binding]; other site 264199004635 substrate binding site [chemical binding]; other site 264199004636 catalytic residues [active] 264199004637 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 264199004638 NeuB family; Region: NeuB; cl00496 264199004639 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 264199004640 NeuB family; Region: NeuB; cl00496 264199004641 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 264199004642 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 264199004643 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199004644 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 264199004645 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 264199004646 nucleotide binding region [chemical binding]; other site 264199004647 ATP-binding site [chemical binding]; other site 264199004648 SEC-C motif; Region: SEC-C; pfam02810 264199004649 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 264199004650 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 264199004651 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 264199004652 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 264199004653 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 264199004654 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 264199004655 active site turn [active] 264199004656 phosphorylation site [posttranslational modification] 264199004657 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 264199004658 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 264199004659 HPr interaction site; other site 264199004660 glycerol kinase (GK) interaction site [polypeptide binding]; other site 264199004661 active site 264199004662 phosphorylation site [posttranslational modification] 264199004663 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 264199004664 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 264199004665 substrate binding [chemical binding]; other site 264199004666 active site 264199004667 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 264199004668 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 264199004669 DNA binding site [nucleotide binding] 264199004670 domain linker motif; other site 264199004671 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 264199004672 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 264199004673 putative RNA binding site [nucleotide binding]; other site 264199004674 Protein of unknown function (DUF322); Region: DUF322; cl00574 264199004675 elongation factor P; Validated; Region: PRK00529 264199004676 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 264199004677 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 264199004678 RNA binding site [nucleotide binding]; other site 264199004679 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 264199004680 RNA binding site [nucleotide binding]; other site 264199004681 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 264199004682 catalytic motif [active] 264199004683 Zn binding site [ion binding]; other site 264199004684 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 264199004685 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 264199004686 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 264199004687 active site 264199004688 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199004689 Q-loop/lid; other site 264199004690 ABC transporter signature motif; other site 264199004691 Walker B; other site 264199004692 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 264199004693 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 264199004694 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 264199004695 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 264199004696 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 264199004697 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 264199004698 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 264199004699 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 264199004700 Domain of unknown function (DUF4300); Region: DUF4300; pfam14133 264199004701 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 264199004702 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 264199004703 dimer interface [polypeptide binding]; other site 264199004704 ssDNA binding site [nucleotide binding]; other site 264199004705 tetramer (dimer of dimers) interface [polypeptide binding]; other site 264199004706 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 264199004707 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 264199004708 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 264199004709 minor groove reading motif; other site 264199004710 helix-hairpin-helix signature motif; other site 264199004711 substrate binding pocket [chemical binding]; other site 264199004712 active site 264199004713 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 264199004714 DNA binding and oxoG recognition site [nucleotide binding] 264199004715 DNA polymerase I; Provisional; Region: PRK05755 264199004716 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 264199004717 active site 264199004718 metal binding site 1 [ion binding]; metal-binding site 264199004719 putative 5' ssDNA interaction site; other site 264199004720 metal binding site 3; metal-binding site 264199004721 metal binding site 2 [ion binding]; metal-binding site 264199004722 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 264199004723 putative DNA binding site [nucleotide binding]; other site 264199004724 putative metal binding site [ion binding]; other site 264199004725 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 264199004726 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 264199004727 active site 264199004728 DNA binding site [nucleotide binding] 264199004729 catalytic site [active] 264199004730 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 264199004731 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 264199004732 Walker A/P-loop; other site 264199004733 ATP binding site [chemical binding]; other site 264199004734 Q-loop/lid; other site 264199004735 ABC transporter signature motif; other site 264199004736 Walker B; other site 264199004737 D-loop; other site 264199004738 H-loop/switch region; other site 264199004739 Smr domain; Region: Smr; cl02619 264199004740 Colicin V production protein; Region: Colicin_V; cl00567 264199004741 ribonuclease HIII; Provisional; Region: PRK00996 264199004742 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 264199004743 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 264199004744 RNA/DNA hybrid binding site [nucleotide binding]; other site 264199004745 active site 264199004746 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 264199004747 Catalytic site [active] 264199004748 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 264199004749 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 264199004750 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 264199004751 AzlC protein; Region: AzlC; cl00570 264199004752 UGMP family protein; Validated; Region: PRK09604 264199004753 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 264199004754 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 264199004755 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 264199004756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 264199004757 Coenzyme A binding pocket [chemical binding]; other site 264199004758 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 264199004759 Protein of unknown function (DUF1447); Region: DUF1447; cl11492 264199004760 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 264199004761 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 264199004762 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 264199004763 NlpC/P60 family; Region: NLPC_P60; cl11438 264199004764 glutamine synthetase, type I; Region: GlnA; TIGR00653 264199004765 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 264199004766 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 264199004767 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 264199004768 DNA binding residues [nucleotide binding] 264199004769 putative dimer interface [polypeptide binding]; other site 264199004770 Bacterial protein of unknown function (DUF939); Region: DUF939; cl12136 264199004771 Transposase; Region: DDE_Tnp_ISL3; pfam01610 264199004772 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 264199004773 Phosphoglycerate kinase; Region: PGK; pfam00162 264199004774 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 264199004775 substrate binding site [chemical binding]; other site 264199004776 hinge regions; other site 264199004777 ADP binding site [chemical binding]; other site 264199004778 catalytic site [active] 264199004779 Transposase IS200 like; Region: Y1_Tnp; cl00848 264199004780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 264199004781 putative transposase OrfB; Reviewed; Region: PHA02517 264199004782 Integrase core domain; Region: rve; cl01316 264199004783 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 264199004784 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 264199004785 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 264199004786 elongation factor G; Reviewed; Region: PRK00007 264199004787 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G; cd01886 264199004788 G1 box; other site 264199004789 putative GEF interaction site [polypeptide binding]; other site 264199004790 GTP/Mg2+ binding site [chemical binding]; other site 264199004791 Switch I region; other site 264199004792 G2 box; other site 264199004793 G3 box; other site 264199004794 Switch II region; other site 264199004795 G4 box; other site 264199004796 G5 box; other site 264199004797 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 264199004798 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 264199004799 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 264199004800 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 264199004801 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 264199004802 S17 interaction site [polypeptide binding]; other site 264199004803 S8 interaction site; other site 264199004804 16S rRNA interaction site [nucleotide binding]; other site 264199004805 streptomycin interaction site [chemical binding]; other site 264199004806 23S rRNA interaction site [nucleotide binding]; other site 264199004807 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 264199004808 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 264199004809 Integrase core domain; Region: rve; cl01316 264199004810 pur operon repressor; Provisional; Region: PRK09213 264199004811 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 264199004812 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 264199004813 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 264199004814 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492 264199004815 generic binding surface II; other site 264199004816 generic binding surface I; other site 264199004817 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 264199004818 Zn2+ binding site [ion binding]; other site 264199004819 Mg2+ binding site [ion binding]; other site 264199004820 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 264199004821 RmuC family; Region: RmuC; pfam02646 264199004822 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 264199004823 Thiamine pyrophosphokinase; Region: TPK; cd07995 264199004824 active site 264199004825 dimerization interface [polypeptide binding]; other site 264199004826 thiamine binding site [chemical binding]; other site 264199004827 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 264199004828 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 264199004829 substrate binding site [chemical binding]; other site 264199004830 hexamer interface [polypeptide binding]; other site 264199004831 metal binding site [ion binding]; metal-binding site 264199004832 GTPase RsgA; Reviewed; Region: PRK00098 264199004833 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854 264199004834 GTPase/OB domain interface [polypeptide binding]; other site 264199004835 GTPase/Zn-binding domain interface [polypeptide binding]; other site 264199004836 GTP/Mg2+ binding site [chemical binding]; other site 264199004837 G4 box; other site 264199004838 G1 box; other site 264199004839 Switch I region; other site 264199004840 G2 box; other site 264199004841 G3 box; other site 264199004842 Switch II region; other site 264199004843 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 264199004844 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 264199004845 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 264199004846 putative active site [active] 264199004847 putative metal binding site [ion binding]; other site 264199004848 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 264199004849 active site 264199004850 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199004851 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 264199004852 catalytic residues [active] 264199004853 Macro domain, Unknown family 1. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_1; cd02906 264199004854 putative ADP-ribose binding site [chemical binding]; other site 264199004855 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 264199004856 catalytic residues [active] 264199004857 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 264199004858 Transposase IS200 like; Region: Y1_Tnp; cl00848 264199004859 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 264199004860 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 264199004861 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 264199004862 G-X-X-G motif; other site 264199004863 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 264199004864 RxxxH motif; other site 264199004865 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 264199004866 Ribonuclease P; Region: Ribonuclease_P; cl00457 264199004867 argininosuccinate lyase; Provisional; Region: PRK00855 264199004868 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 264199004869 active sites [active] 264199004870 tetramer interface [polypeptide binding]; other site 264199004871 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 264199004872 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 264199004873 ANP binding site [chemical binding]; other site 264199004874 Substrate Binding Site II [chemical binding]; other site 264199004875 Substrate Binding Site I [chemical binding]; other site 264199004876 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 264199004877 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 264199004878 active site 264199004879 HIGH motif; other site 264199004880 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 264199004881 active site 264199004882 KMSKS motif; other site 264199004883 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 264199004884 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 264199004885 mRNA/rRNA interface [nucleotide binding]; other site 264199004886 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 264199004887 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 264199004888 23S rRNA interface [nucleotide binding]; other site 264199004889 L7/L12 interface [polypeptide binding]; other site 264199004890 putative thiostrepton binding site; other site 264199004891 L25 interface [polypeptide binding]; other site 264199004892 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 264199004893 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 264199004894 active site clefts [active] 264199004895 zinc binding site [ion binding]; other site 264199004896 dimer interface [polypeptide binding]; other site 264199004897 Protein of unknown function DUF124; Region: DUF124; cl00884 264199004898 Protein of unknown function DUF124; Region: DUF124; cl00884 264199004899 DNA repair protein RadA; Provisional; Region: PRK11823 264199004900 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199004901 Walker A motif; other site 264199004902 ATP binding site [chemical binding]; other site 264199004903 Walker B motif; other site 264199004904 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 264199004905 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 264199004906 trimer interface [polypeptide binding]; other site 264199004907 active site 264199004908 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 264199004909 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 264199004910 Uncharacterized conserved protein [Function unknown]; Region: COG2461 264199004911 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 264199004912 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 264199004913 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 264199004914 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199004915 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 264199004916 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 264199004917 active site 264199004918 tetramer interface; other site 264199004919 putative transposase OrfB; Reviewed; Region: PHA02517 264199004920 Integrase core domain; Region: rve; cl01316 264199004921 Helix-turn-helix domains; Region: HTH; cl00088 264199004922 Helix-turn-helix domains; Region: HTH; cl00088 264199004923 Rhomboid family; Region: Rhomboid; cl11446 264199004924 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 264199004925 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 264199004926 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 264199004927 metal binding site [ion binding]; metal-binding site 264199004928 putative dimer interface [polypeptide binding]; other site 264199004929 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 264199004930 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapD_N; pfam08503 264199004931 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 264199004932 trimer interface [polypeptide binding]; other site 264199004933 active site 264199004934 substrate binding site [chemical binding]; other site 264199004935 CoA binding site [chemical binding]; other site 264199004936 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 264199004937 motif II; other site 264199004938 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 264199004939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 264199004940 S-adenosylmethionine binding site [chemical binding]; other site 264199004941 class IIb bacteriocin, lactobin A/cerein 7B family; Region: bact_IIb_cerein; TIGR03949 264199004942 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 264199004943 nucleoside/Zn binding site; other site 264199004944 dimer interface [polypeptide binding]; other site 264199004945 catalytic motif [active] 264199004946 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 264199004947 dimer interface [polypeptide binding]; other site 264199004948 ssDNA binding site [nucleotide binding]; other site 264199004949 tetramer (dimer of dimers) interface [polypeptide binding]; other site 264199004950 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 264199004951 CPxP motif; other site 264199004952 YeeE/YedE family (DUF395); Region: DUF395; cl01018 264199004953 putative inner membrane protein; Provisional; Region: PRK11099 264199004954 YeeE/YedE family (DUF395); Region: DUF395; cl01018 264199004955 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 264199004956 putative tRNA-binding site [nucleotide binding]; other site 264199004957 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 264199004958 catalytic residues [active] 264199004959 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 264199004960 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 264199004961 oligomer interface [polypeptide binding]; other site 264199004962 active site 264199004963 metal binding site [ion binding]; metal-binding site 264199004964 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 264199004965 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199004966 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 264199004967 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 264199004968 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 264199004969 non-specific DNA binding site [nucleotide binding]; other site 264199004970 salt bridge; other site 264199004971 sequence-specific DNA binding site [nucleotide binding]; other site 264199004972 Acetokinase family; Region: Acetate_kinase; cl01029 264199004973 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 264199004974 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 264199004975 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 264199004976 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 264199004977 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 264199004978 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 264199004979 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 264199004980 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 264199004981 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199004982 Walker A motif; other site 264199004983 ATP binding site [chemical binding]; other site 264199004984 Walker B motif; other site 264199004985 Protein of unknown function (DUF1033); Region: DUF1033; cl11549 264199004986 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 264199004987 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 264199004988 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 264199004989 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 264199004990 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 264199004991 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 264199004992 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 264199004993 G-loop; other site 264199004994 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 264199004995 DNA binding site [nucleotide binding] 264199004996 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 264199004997 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 264199004998 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 264199004999 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 264199005000 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 264199005001 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 264199005002 RPB1 interaction site [polypeptide binding]; other site 264199005003 RPB10 interaction site [polypeptide binding]; other site 264199005004 RPB11 interaction site [polypeptide binding]; other site 264199005005 RPB3 interaction site [polypeptide binding]; other site 264199005006 RPB12 interaction site [polypeptide binding]; other site 264199005007 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 264199005008 Transglycosylase; Region: Transgly; cl07896 264199005009 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 264199005010 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 264199005011 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 264199005012 active site 264199005013 HIGH motif; other site 264199005014 dimer interface [polypeptide binding]; other site 264199005015 KMSKS motif; other site 264199005016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264199005017 RNA binding surface [nucleotide binding]; other site 264199005018 ketol-acid reductoisomerase; Provisional; Region: PRK05479 264199005019 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199005020 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 264199005021 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 264199005022 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 264199005023 putative valine binding site [chemical binding]; other site 264199005024 dimer interface [polypeptide binding]; other site 264199005025 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 264199005026 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 264199005027 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 264199005028 PYR/PP interface [polypeptide binding]; other site 264199005029 dimer interface [polypeptide binding]; other site 264199005030 TPP binding site [chemical binding]; other site 264199005031 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 264199005032 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 264199005033 TPP-binding site [chemical binding]; other site 264199005034 dimer interface [polypeptide binding]; other site 264199005035 Dehydratase family; Region: ILVD_EDD; cl00340 264199005036 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 264199005037 DAK2 domain; Region: Dak2; cl03685 264199005038 Protein of unknown function (DUF322); Region: DUF322; cl00574 264199005039 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 264199005040 MatE; Region: MatE; cl10513 264199005041 MatE; Region: MatE; cl10513 264199005042 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560 264199005043 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 264199005044 pyridoxal 5'-phosphate binding site [chemical binding]; other site 264199005045 catalytic residue [active] 264199005046 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 264199005047 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 264199005048 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 264199005049 active site 264199005050 NAD binding site [chemical binding]; other site 264199005051 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 264199005052 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 264199005053 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 264199005054 catalytic residues [active] 264199005055 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 264199005056 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 264199005057 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 264199005058 active site 264199005059 Zn binding site [ion binding]; other site 264199005060 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 264199005061 maltodextrin glucosidase; Provisional; Region: PRK10785 264199005062 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 264199005063 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 264199005064 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 264199005065 HPr interaction site; other site 264199005066 glycerol kinase (GK) interaction site [polypeptide binding]; other site 264199005067 active site 264199005068 phosphorylation site [posttranslational modification] 264199005069 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 264199005070 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 264199005071 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 264199005072 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 264199005073 DNA-binding site [nucleotide binding]; DNA binding site 264199005074 UTRA domain; Region: UTRA; cl01230 264199005075 Protein of unknown function (DUF436); Region: DUF436; cl01860 264199005076 Integrase core domain; Region: rve; cl01316 264199005077 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 264199005078 hypothetical protein; Provisional; Region: PRK08185 264199005079 intersubunit interface [polypeptide binding]; other site 264199005080 active site 264199005081 zinc binding site [ion binding]; other site 264199005082 Na+ binding site [ion binding]; other site 264199005083 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 264199005084 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 264199005085 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 264199005086 Integrase core domain; Region: rve; cl01316 264199005087 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 264199005088 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 264199005089 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 264199005090 alphaNTD homodimer interface [polypeptide binding]; other site 264199005091 alphaNTD - beta interaction site [polypeptide binding]; other site 264199005092 alphaNTD - beta' interaction site [polypeptide binding]; other site 264199005093 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 264199005094 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 264199005095 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 264199005096 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 264199005097 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 264199005098 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 264199005099 rRNA binding site [nucleotide binding]; other site 264199005100 predicted 30S ribosome binding site; other site 264199005101 adenylate kinase; Reviewed; Region: adk; PRK00279 264199005102 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 264199005103 AMP-binding site [chemical binding]; other site 264199005104 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 264199005105 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 264199005106 SecY translocase; Region: SecY; pfam00344 264199005107 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 264199005108 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 264199005109 23S rRNA binding site [nucleotide binding]; other site 264199005110 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 264199005111 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 264199005112 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 264199005113 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 264199005114 23S rRNA interface [nucleotide binding]; other site 264199005115 L21e interface [polypeptide binding]; other site 264199005116 5S rRNA interface [nucleotide binding]; other site 264199005117 L27 interface [polypeptide binding]; other site 264199005118 L5 interface [polypeptide binding]; other site 264199005119 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 264199005120 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 264199005121 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 264199005122 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 264199005123 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 264199005124 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 264199005125 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 264199005126 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 264199005127 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 264199005128 KOW motif; Region: KOW; cl00354 264199005129 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 264199005130 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 264199005131 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 264199005132 23S rRNA interface [nucleotide binding]; other site 264199005133 putative translocon interaction site; other site 264199005134 signal recognition particle (SRP54) interaction site; other site 264199005135 L23 interface [polypeptide binding]; other site 264199005136 trigger factor interaction site; other site 264199005137 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 264199005138 23S rRNA interface [nucleotide binding]; other site 264199005139 5S rRNA interface [nucleotide binding]; other site 264199005140 putative antibiotic binding site [chemical binding]; other site 264199005141 L25 interface [polypeptide binding]; other site 264199005142 L27 interface [polypeptide binding]; other site 264199005143 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 264199005144 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 264199005145 G-X-X-G motif; other site 264199005146 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 264199005147 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 264199005148 putative translocon binding site; other site 264199005149 protein-rRNA interface [nucleotide binding]; other site 264199005150 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 264199005151 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 264199005152 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 264199005153 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 264199005154 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 264199005155 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 264199005156 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 264199005157 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 264199005158 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 264199005159 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264199005160 Walker A motif; other site 264199005161 ATP binding site [chemical binding]; other site 264199005162 Walker B motif; other site 264199005163 arginine finger; other site 264199005164 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 264199005165 OpgC protein; Region: OpgC_C; cl00792 264199005166 Acyltransferase family; Region: Acyl_transf_3; pfam01757 264199005167 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 264199005168 catalytic triad [active] 264199005169 catalytic triad [active] 264199005170 oxyanion hole [active] 264199005171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 264199005172 Low molecular weight phosphatase family; Region: LMWPc; cd00115 264199005173 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 264199005174 active site 264199005175 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 264199005176 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 264199005177 GDP-binding site [chemical binding]; other site 264199005178 ACT binding site; other site 264199005179 IMP binding site; other site 264199005180 Adenylate kinase and related kinases [Nucleotide transport and metabolism]; Region: Adk; COG0563 264199005181 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199005182 Transposase, Mutator family; Region: Transposase_mut; pfam00872 264199005183 MULE transposase domain; Region: MULE; pfam10551 264199005184 Helix-turn-helix domains; Region: HTH; cl00088 264199005185 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 264199005186 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 264199005187 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 264199005188 active site 264199005189 ATP binding site [chemical binding]; other site 264199005190 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264199005191 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 264199005192 Walker A/P-loop; other site 264199005193 ATP binding site [chemical binding]; other site 264199005194 Q-loop/lid; other site 264199005195 ABC transporter signature motif; other site 264199005196 Walker B; other site 264199005197 D-loop; other site 264199005198 H-loop/switch region; other site 264199005199 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 264199005200 anaerobic sulfatase-maturase; Provisional; Region: PRK13758 264199005201 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264199005202 FeS/SAM binding site; other site 264199005203 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 264199005204 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199005205 Walker A/P-loop; other site 264199005206 ATP binding site [chemical binding]; other site 264199005207 Q-loop/lid; other site 264199005208 ABC transporter signature motif; other site 264199005209 Walker B; other site 264199005210 D-loop; other site 264199005211 H-loop/switch region; other site 264199005212 Replication initiation factor; Region: Rep_trans; pfam02486 264199005213 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 264199005214 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 264199005215 Phage integrase family; Region: Phage_integrase; pfam00589 264199005216 Int/Topo IB signature motif; other site 264199005217 recombination factor protein RarA; Reviewed; Region: PRK13342 264199005218 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 264199005219 Walker A motif; other site 264199005220 ATP binding site [chemical binding]; other site 264199005221 Walker B motif; other site 264199005222 arginine finger; other site 264199005223 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 264199005224 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 264199005225 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 264199005226 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 264199005227 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 264199005228 Predicted membrane protein (DUF2079); Region: DUF2079; cl01374 264199005229 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 264199005230 ATP cone domain; Region: ATP-cone; pfam03477 264199005231 Class III ribonucleotide reductase; Region: RNR_III; cd01675 264199005232 effector binding site; other site 264199005233 active site 264199005234 Zn binding site [ion binding]; other site 264199005235 glycine loop; other site 264199005236 Predicted acetyltransferase [General function prediction only]; Region: COG3981 264199005237 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 264199005238 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 264199005239 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 264199005240 FeS/SAM binding site; other site 264199005241 Protein of unknown function (DUF328); Region: DUF328; cl01143 264199005242 Uncharacterized conserved protein [Function unknown]; Region: COG1284 264199005243 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 264199005244 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 264199005245 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 264199005246 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 264199005247 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 264199005248 dimer interface [polypeptide binding]; other site 264199005249 anticodon binding site; other site 264199005250 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 264199005251 homodimer interface [polypeptide binding]; other site 264199005252 motif 1; other site 264199005253 active site 264199005254 motif 2; other site 264199005255 GAD domain; Region: GAD; pfam02938 264199005256 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 264199005257 motif 3; other site 264199005258 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 264199005259 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 264199005260 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 264199005261 dimer interface [polypeptide binding]; other site 264199005262 motif 1; other site 264199005263 active site 264199005264 motif 2; other site 264199005265 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 264199005266 anticodon binding site; other site 264199005267 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 264199005268 substrate binding site [chemical binding]; other site 264199005269 zinc-binding site [ion binding]; other site 264199005270 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 264199005271 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 264199005272 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 264199005273 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 264199005274 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 264199005275 Domain of unknown function (DUF389); Region: DUF389; cl00781 264199005276 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 264199005277 Small integral membrane protein (DUF2273); Region: DUF2273; cl11575 264199005278 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 264199005279 Integrase core domain; Region: rve; cl01316 264199005280 Protein of unknown function (DUF322); Region: DUF322; cl00574 264199005281 CsbD-like; Region: CsbD; cl01888 264199005282 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 264199005283 putative active site [active] 264199005284 putative CoA binding site [chemical binding]; other site 264199005285 nudix motif; other site 264199005286 metal binding site [ion binding]; metal-binding site 264199005287 Helix-turn-helix domains; Region: HTH; cl00088 264199005288 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 264199005289 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 264199005290 Predicted membrane protein [Function unknown]; Region: COG1511 264199005291 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 264199005292 ABC-2 type transporter; Region: ABC2_membrane; cl11417 264199005293 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 264199005294 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 264199005295 Helix-turn-helix domains; Region: HTH; cl00088 264199005296 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 264199005297 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 264199005298 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 264199005299 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 264199005300 RNA binding surface [nucleotide binding]; other site 264199005301 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 264199005302 replicative DNA helicase; Provisional; Region: PRK05748 264199005303 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 264199005304 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 264199005305 Walker A motif; other site 264199005306 ATP binding site [chemical binding]; other site 264199005307 Walker B motif; other site 264199005308 DNA binding loops [nucleotide binding] 264199005309 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 264199005310 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 264199005311 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 264199005312 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 264199005313 DHH family; Region: DHH; pfam01368 264199005314 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 264199005315 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 264199005316 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 264199005317 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 264199005318 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 264199005319 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 264199005320 putative peptidoglycan binding site; other site 264199005321 Cobalt transport protein; Region: CbiQ; cl00463 264199005322 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 264199005323 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 264199005324 Walker A/P-loop; other site 264199005325 ATP binding site [chemical binding]; other site 264199005326 Q-loop/lid; other site 264199005327 ABC transporter signature motif; other site 264199005328 Walker B; other site 264199005329 D-loop; other site 264199005330 H-loop/switch region; other site 264199005331 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 264199005332 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 264199005333 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 264199005334 Walker A/P-loop; other site 264199005335 ATP binding site [chemical binding]; other site 264199005336 Q-loop/lid; other site 264199005337 ABC transporter signature motif; other site 264199005338 Walker B; other site 264199005339 D-loop; other site 264199005340 H-loop/switch region; other site 264199005341 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 264199005342 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 264199005343 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 264199005344 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264199005345 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 264199005346 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264199005347 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 264199005348 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 264199005349 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 264199005350 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 264199005351 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 264199005352 Walker A/P-loop; other site 264199005353 ATP binding site [chemical binding]; other site 264199005354 Q-loop/lid; other site 264199005355 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 264199005356 ABC transporter signature motif; other site 264199005357 Walker B; other site 264199005358 D-loop; other site 264199005359 H-loop/switch region; other site 264199005360 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 264199005361 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 264199005362 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 264199005363 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 264199005364 active site 264199005365 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 264199005366 Integrase core domain; Region: rve; cl01316 264199005367 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 264199005368 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 264199005369 active site 264199005370 HIGH motif; other site 264199005371 dimer interface [polypeptide binding]; other site 264199005372 KMSKS motif; other site 264199005373 Uncharacterized conserved protein [Function unknown]; Region: COG1284 264199005374 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 264199005375 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 264199005376 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 264199005377 Walker A/P-loop; other site 264199005378 ATP binding site [chemical binding]; other site 264199005379 Q-loop/lid; other site 264199005380 ABC transporter signature motif; other site 264199005381 Walker B; other site 264199005382 D-loop; other site 264199005383 H-loop/switch region; other site 264199005384 ABC transporter; Region: ABC_tran_2; pfam12848 264199005385 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 264199005386 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 264199005387 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 264199005388 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 264199005389 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 264199005390 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 264199005391 protein binding site [polypeptide binding]; other site 264199005392 ParB-like partition proteins; Region: parB_part; TIGR00180 264199005393 ParB-like nuclease domain; Region: ParBc; cl02129