-- dump date 20111121_015201 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type NP_821175.1 29826541 1211754 complement(1380..1811) 1 NC_003155.4 hypothetical protein 1811 1211754 SAV_1 Streptomyces avermitilis MA-4680 hypothetical protein NP_821175.1 1380 R 227882 CDS NP_821176.1 29826542 1211755 2466..2699 1 NC_003155.4 PF04851: Type III restriction enzyme, res subunit; hypothetical protein 2699 1211755 SAV_2 Streptomyces avermitilis MA-4680 hypothetical protein NP_821176.1 2466 D 227882 CDS NP_821177.1 29826543 1211756 2765..3310 1 NC_003155.4 endonuclease VII 3310 1211756 SAV_3 Streptomyces avermitilis MA-4680 endonuclease VII NP_821177.1 2765 D 227882 CDS NP_821178.1 29826544 1211757 complement(3433..3939) 1 NC_003155.4 hypothetical protein 3939 1211757 SAV_4 Streptomyces avermitilis MA-4680 hypothetical protein NP_821178.1 3433 R 227882 CDS NP_821179.1 29826545 1211758 3994..4932 1 NC_003155.4 PF07336: Protein of unknown function (DUF1470); hypothetical protein 4932 1211758 SAV_5 Streptomyces avermitilis MA-4680 hypothetical protein NP_821179.1 3994 D 227882 CDS NP_821180.1 29826546 1211759 4936..7563 1 NC_003155.4 helicase 7563 1211759 SAV_6 Streptomyces avermitilis MA-4680 helicase NP_821180.1 4936 D 227882 CDS NP_821181.1 29826547 1211760 7554..9626 1 NC_003155.4 PF00589: Phage integrase family; transposase 9626 1211760 SAV_7 Streptomyces avermitilis MA-4680 transposase NP_821181.1 7554 D 227882 CDS NP_821182.1 29826548 1211761 complement(9886..10635) 1 NC_003155.4 hypothetical protein 10635 1211761 SAV_8 Streptomyces avermitilis MA-4680 hypothetical protein NP_821182.1 9886 R 227882 CDS NP_821183.1 29826549 1211762 complement(10632..10805) 1 NC_003155.4 hypothetical protein 10805 1211762 SAV_9 Streptomyces avermitilis MA-4680 hypothetical protein NP_821183.1 10632 R 227882 CDS NP_821184.1 29826550 1211763 complement(11101..13497) 1 NC_003155.4 hypothetical protein 13497 1211763 SAV_10 Streptomyces avermitilis MA-4680 hypothetical protein NP_821184.1 11101 R 227882 CDS NP_821185.1 29826551 1211764 complement(13376..15523) 1 NC_003155.4 PF00004: ATPase family associated with various cellular activities (AAA); hypothetical protein 15523 1211764 SAV_11 Streptomyces avermitilis MA-4680 hypothetical protein NP_821185.1 13376 R 227882 CDS NP_821186.1 29826552 1211765 complement(15815..17701) 1 NC_003155.4 PF00805: Pentapeptide repeats (8 copies); hypothetical protein 17701 1211765 SAV_12 Streptomyces avermitilis MA-4680 hypothetical protein NP_821186.1 15815 R 227882 CDS NP_821187.1 29826553 1211766 17828..18922 1 NC_003155.4 PF03457: Helicase associated domain; hypothetical protein 18922 1211766 SAV_13 Streptomyces avermitilis MA-4680 hypothetical protein NP_821187.1 17828 D 227882 CDS NP_821188.1 29826554 1211767 19446..20279 1 NC_003155.4 hypothetical protein 20279 1211767 SAV_14 Streptomyces avermitilis MA-4680 hypothetical protein NP_821188.1 19446 D 227882 CDS NP_821189.1 29826555 1211768 21562..22080 1 NC_003155.4 hypothetical protein 22080 1211768 SAV_15 Streptomyces avermitilis MA-4680 hypothetical protein NP_821189.1 21562 D 227882 CDS NP_821190.1 29826556 1211769 22243..22770 1 NC_003155.4 hypothetical protein 22770 1211769 SAV_16 Streptomyces avermitilis MA-4680 hypothetical protein NP_821190.1 22243 D 227882 CDS NP_821191.1 29826557 1211770 23457..23621 1 NC_003155.4 hypothetical protein 23621 1211770 SAV_17 Streptomyces avermitilis MA-4680 hypothetical protein NP_821191.1 23457 D 227882 CDS NP_821192.1 29826558 1211771 23675..24559 1 NC_003155.4 IS1647-like transposase 24559 1211771 SAV_18 Streptomyces avermitilis MA-4680 IS1647-like transposase NP_821192.1 23675 D 227882 CDS NP_821193.1 29826559 1211772 complement(24570..24983) 1 NC_003155.4 hypothetical protein 24983 1211772 SAV_19 Streptomyces avermitilis MA-4680 hypothetical protein NP_821193.1 24570 R 227882 CDS NP_821194.1 29826560 1211773 complement(25166..25690) 1 NC_003155.4 hypothetical protein 25690 1211773 SAV_20 Streptomyces avermitilis MA-4680 hypothetical protein NP_821194.1 25166 R 227882 CDS NP_821195.1 29826561 1211774 complement(25699..29451) 1 NC_003155.4 PF05593: RHS Repeat; Rhs protein 29451 rhsA 1211774 rhsA Streptomyces avermitilis MA-4680 Rhs protein NP_821195.1 25699 R 227882 CDS NP_821196.1 29826562 1211775 complement(29508..30080) 1 NC_003155.4 hypothetical protein 30080 1211775 SAV_22 Streptomyces avermitilis MA-4680 hypothetical protein NP_821196.1 29508 R 227882 CDS NP_821197.1 29826563 1211776 complement(30107..30394) 1 NC_003155.4 hypothetical protein 30394 1211776 SAV_23 Streptomyces avermitilis MA-4680 hypothetical protein NP_821197.1 30107 R 227882 CDS NP_821198.1 29826564 1211777 complement(30394..31323) 1 NC_003155.4 hypothetical protein 31323 1211777 SAV_24 Streptomyces avermitilis MA-4680 hypothetical protein NP_821198.1 30394 R 227882 CDS NP_821199.1 29826565 1211778 complement(32197..32559) 1 NC_003155.4 hypothetical protein 32559 1211778 SAV_25 Streptomyces avermitilis MA-4680 hypothetical protein NP_821199.1 32197 R 227882 CDS NP_821200.1 29826566 1210016 complement(32552..33124) 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 33124 sig1 1210016 sig1 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_821200.1 32552 R 227882 CDS NP_821201.1 29826567 1211779 complement(33121..33411) 1 NC_003155.4 hypothetical protein 33411 1211779 SAV_27 Streptomyces avermitilis MA-4680 hypothetical protein NP_821201.1 33121 R 227882 CDS NP_821202.1 29826568 1211780 34056..35792 1 NC_003155.4 two-component system sensor kinase 35792 1211780 SAV_28 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_821202.1 34056 D 227882 CDS NP_821203.1 29826569 1211781 37315..37656 1 NC_003155.4 ParR family transcriptional regulator 37656 1211781 SAV_29 Streptomyces avermitilis MA-4680 ParR family transcriptional regulator NP_821203.1 37315 D 227882 CDS NP_821204.1 29826570 1211782 37653..38609 1 NC_003155.4 hypothetical protein 38609 1211782 SAV_30 Streptomyces avermitilis MA-4680 hypothetical protein NP_821204.1 37653 D 227882 CDS NP_821205.1 29826571 1211783 38623..39624 1 NC_003155.4 PF01569: PAP2 superfamily; prepilin peptidase-like protein 39624 1211783 SAV_31 Streptomyces avermitilis MA-4680 prepilin peptidase-like protein NP_821205.1 38623 D 227882 CDS NP_821206.1 29826572 1211784 41010..41612 1 NC_003155.4 hypothetical protein 41612 1211784 SAV_32 Streptomyces avermitilis MA-4680 hypothetical protein NP_821206.1 41010 D 227882 CDS NP_821207.1 29826573 1211785 complement(41665..41967) 1 NC_003155.4 hypothetical protein 41967 1211785 SAV_33 Streptomyces avermitilis MA-4680 hypothetical protein NP_821207.1 41665 R 227882 CDS NP_821208.1 29826574 1211786 42010..44046 1 NC_003155.4 hypothetical protein 44046 1211786 SAV_34 Streptomyces avermitilis MA-4680 hypothetical protein NP_821208.1 42010 D 227882 CDS NP_821209.1 29826575 1211787 complement(44107..44958) 1 NC_003155.4 hypothetical protein 44958 1211787 SAV_35 Streptomyces avermitilis MA-4680 hypothetical protein NP_821209.1 44107 R 227882 CDS NP_821210.1 29826576 1211788 complement(45160..45432) 1 NC_003155.4 hypothetical protein 45432 1211788 SAV_36 Streptomyces avermitilis MA-4680 hypothetical protein NP_821210.1 45160 R 227882 CDS NP_821211.1 29826577 1211789 complement(45819..47141) 1 NC_003155.4 hypothetical protein 47141 1211789 SAV_37 Streptomyces avermitilis MA-4680 hypothetical protein NP_821211.1 45819 R 227882 CDS NP_821212.1 29826578 1211790 complement(47239..48180) 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 48180 1211790 SAV_38 Streptomyces avermitilis MA-4680 hydrolase NP_821212.1 47239 R 227882 CDS NP_821213.1 29826579 1211791 49166..49456 1 NC_003155.4 probably pseudogene; terminal protein Tpg-like protein 49456 1211791 SAV_39 Streptomyces avermitilis MA-4680 terminal protein Tpg-like protein NP_821213.1 49166 D 227882 CDS NP_821214.1 29826580 1211792 complement(49694..50434) 1 NC_003155.4 hypothetical protein 50434 1211792 SAV_40 Streptomyces avermitilis MA-4680 hypothetical protein NP_821214.1 49694 R 227882 CDS NP_821215.1 29826581 1211793 complement(50521..50901) 1 NC_003155.4 hypothetical protein 50901 1211793 SAV_41 Streptomyces avermitilis MA-4680 hypothetical protein NP_821215.1 50521 R 227882 CDS NP_821216.1 29826582 1211794 51232..52623 1 NC_003155.4 hypothetical protein 52623 1211794 SAV_42 Streptomyces avermitilis MA-4680 hypothetical protein NP_821216.1 51232 D 227882 CDS NP_821217.1 29826583 1211795 53113..53505 1 NC_003155.4 Tn5741 family, partial; Tn5741 family transposase 53505 1211795 SAV_43 Streptomyces avermitilis MA-4680 Tn5741 family transposase NP_821217.1 53113 D 227882 CDS NP_821218.1 29826584 1211796 54215..55330 1 NC_003155.4 PF07470: Glycosyl Hydrolase Family 88; unsaturated glucuronyl hydrolase 55330 1211796 SAV_44 Streptomyces avermitilis MA-4680 unsaturated glucuronyl hydrolase NP_821218.1 54215 D 227882 CDS NP_821219.1 29826585 1211797 complement(55687..56061) 1 NC_003155.4 IS5 family transposase 56061 1211797 SAV_45 Streptomyces avermitilis MA-4680 IS5 family transposase NP_821219.1 55687 R 227882 CDS NP_821220.1 29826586 1211798 complement(56052..56441) 1 NC_003155.4 IS5 family; IS1647-like transposase 56441 1211798 SAV_46 Streptomyces avermitilis MA-4680 IS1647-like transposase NP_821220.1 56052 R 227882 CDS NP_821221.1 29826587 1211799 56620..57810 1 NC_003155.4 IS200/IS605 family; IS200-like transposase 57810 1211799 SAV_47 Streptomyces avermitilis MA-4680 IS200-like transposase NP_821221.1 56620 D 227882 CDS NP_821222.1 29826588 1211800 complement(58168..58824) 1 NC_003155.4 hypothetical protein 58824 1211800 SAV_48 Streptomyces avermitilis MA-4680 hypothetical protein NP_821222.1 58168 R 227882 CDS NP_821223.1 29826589 1211801 58919..59212 1 NC_003155.4 hypothetical protein 59212 1211801 SAV_49 Streptomyces avermitilis MA-4680 hypothetical protein NP_821223.1 58919 D 227882 CDS NP_821224.1 29826590 1211802 complement(59260..61488) 1 NC_003155.4 hypothetical protein 61488 1211802 SAV_50 Streptomyces avermitilis MA-4680 hypothetical protein NP_821224.1 59260 R 227882 CDS NP_821225.1 29826591 1211803 complement(62242..62751) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 62751 1211803 SAV_51 Streptomyces avermitilis MA-4680 acetyltransferase NP_821225.1 62242 R 227882 CDS NP_821226.1 29826592 1211804 complement(62965..63342) 1 NC_003155.4 hypothetical protein 63342 1211804 SAV_52 Streptomyces avermitilis MA-4680 hypothetical protein NP_821226.1 62965 R 227882 CDS NP_821227.1 29826593 1211805 63529..64401 1 NC_003155.4 transcriptional regulatory protein 64401 1211805 SAV_53 Streptomyces avermitilis MA-4680 transcriptional regulatory protein NP_821227.1 63529 D 227882 CDS NP_821228.1 29826594 1211806 complement(64481..64588) 1 NC_003155.4 hypothetical protein 64588 1211806 SAV_54 Streptomyces avermitilis MA-4680 hypothetical protein NP_821228.1 64481 R 227882 CDS NP_821229.1 29826595 1211807 complement(64632..65045) 1 NC_003155.4 hypothetical protein 65045 1211807 SAV_55 Streptomyces avermitilis MA-4680 hypothetical protein NP_821229.1 64632 R 227882 CDS NP_821230.1 29826596 1211808 complement(65216..65398) 1 NC_003155.4 hypothetical protein 65398 1211808 SAV_56 Streptomyces avermitilis MA-4680 hypothetical protein NP_821230.1 65216 R 227882 CDS NP_821231.1 29826597 1211809 complement(65536..66591) 1 NC_003155.4 PF01833: IPT/TIG domain; hypothetical protein 66591 1211809 SAV_57 Streptomyces avermitilis MA-4680 hypothetical protein NP_821231.1 65536 R 227882 CDS NP_821232.1 29826598 1211810 complement(66803..67546) 1 NC_003155.4 PF01833: IPT/TIG domain; hypothetical protein 67546 1211810 SAV_58 Streptomyces avermitilis MA-4680 hypothetical protein NP_821232.1 66803 R 227882 CDS NP_821233.1 29826599 1211811 69136..69402 1 NC_003155.4 hypothetical protein 69402 1211811 SAV_59 Streptomyces avermitilis MA-4680 hypothetical protein NP_821233.1 69136 D 227882 CDS NP_821234.1 29826600 1211812 complement(70102..70617) 1 NC_003155.4 hypothetical protein 70617 1211812 SAV_60 Streptomyces avermitilis MA-4680 hypothetical protein NP_821234.1 70102 R 227882 CDS NP_821235.1 29826601 1211813 complement(70718..71920) 1 NC_003155.4 IS200/IS605 family; IS200-like transposase 71920 1211813 SAV_61 Streptomyces avermitilis MA-4680 IS200-like transposase NP_821235.1 70718 R 227882 CDS NP_821236.1 29826602 1211814 72189..72680 1 NC_003155.4 transmembrane transport protein 72680 1211814 SAV_62 Streptomyces avermitilis MA-4680 transmembrane transport protein NP_821236.1 72189 D 227882 CDS NP_821237.1 29826603 1211815 72680..72901 1 NC_003155.4 transcriptional regulatory protein 72901 1211815 SAV_63 Streptomyces avermitilis MA-4680 transcriptional regulatory protein NP_821237.1 72680 D 227882 CDS NP_821238.1 29826604 1211816 73063..73698 1 NC_003155.4 hypothetical protein 73698 1211816 SAV_64 Streptomyces avermitilis MA-4680 hypothetical protein NP_821238.1 73063 D 227882 CDS NP_821239.1 29826605 1211817 74098..74520 1 NC_003155.4 hypothetical protein 74520 1211817 SAV_65 Streptomyces avermitilis MA-4680 hypothetical protein NP_821239.1 74098 D 227882 CDS NP_821240.1 29826606 1211818 complement(74429..74899) 1 NC_003155.4 IS200/IS605 family, truncated; IS200-like transposase 74899 1211818 SAV_66 Streptomyces avermitilis MA-4680 IS200-like transposase NP_821240.1 74429 R 227882 CDS NP_821241.1 29826607 1211819 75600..76676 1 NC_003155.4 PF00165: Bacterial regulatory helix-turn-helix proteins, araC family; regulatory protein 76676 1211819 SAV_67 Streptomyces avermitilis MA-4680 regulatory protein NP_821241.1 75600 D 227882 CDS NP_821242.1 29826608 1211820 77069..78430 1 NC_003155.4 hypothetical protein 78430 1211820 SAV_68 Streptomyces avermitilis MA-4680 hypothetical protein NP_821242.1 77069 D 227882 CDS NP_821243.1 29826609 1211821 78733..78972 1 NC_003155.4 hypothetical protein 78972 1211821 SAV_69 Streptomyces avermitilis MA-4680 hypothetical protein NP_821243.1 78733 D 227882 CDS NP_821244.1 29826610 1211822 complement(79005..79262) 1 NC_003155.4 hypothetical protein 79262 1211822 SAV_70 Streptomyces avermitilis MA-4680 hypothetical protein NP_821244.1 79005 R 227882 CDS NP_821245.1 29826611 1211823 79425..79850 1 NC_003155.4 PF03364: Streptomyces cyclase/dehydrase; putavie cyclase/dehydrase 79850 1211823 SAV_71 Streptomyces avermitilis MA-4680 putavie cyclase/dehydrase NP_821245.1 79425 D 227882 CDS NP_821246.1 29826612 1211824 complement(80560..82215) 1 NC_003155.4 two-component system sensor kinase 82215 1211824 SAV_72 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_821246.1 80560 R 227882 CDS NP_821247.1 29826613 1211825 complement(82208..82954) 1 NC_003155.4 two-component system response regulator 82954 1211825 SAV_73 Streptomyces avermitilis MA-4680 two-component system response regulator NP_821247.1 82208 R 227882 CDS NP_821248.1 29826614 1211826 83059..84600 1 NC_003155.4 hypothetical protein 84600 1211826 SAV_74 Streptomyces avermitilis MA-4680 hypothetical protein NP_821248.1 83059 D 227882 CDS NP_821249.1 29826615 1211827 85042..85431 1 NC_003155.4 PF01042: Endoribonuclease L-PSP; endoribonuclease L-PSP 85431 1211827 SAV_75 Streptomyces avermitilis MA-4680 endoribonuclease L-PSP NP_821249.1 85042 D 227882 CDS NP_821250.1 29826616 1210017 86073..87080 1 NC_003155.4 terpene biosynthesis; terpene cyclase 87080 tpc1 1210017 tpc1 Streptomyces avermitilis MA-4680 terpene cyclase NP_821250.1 86073 D 227882 CDS NP_821251.1 29826617 1211828 complement(87168..87629) 1 NC_003155.4 truncated methyltransferase; hypothetical protein 87629 1211828 SAV_77 Streptomyces avermitilis MA-4680 hypothetical protein NP_821251.1 87168 R 227882 CDS NP_821252.1 29826618 1211829 complement(87716..88276) 1 NC_003155.4 hypothetical protein 88276 1211829 SAV_78 Streptomyces avermitilis MA-4680 hypothetical protein NP_821252.1 87716 R 227882 CDS NP_821253.2 57833847 1211830 complement(88693..89706) 1 NC_003155.4 hypothetical protein 89706 1211830 SAV_79 Streptomyces avermitilis MA-4680 hypothetical protein NP_821253.2 88693 R 227882 CDS NP_821254.1 29826620 1211831 complement(89844..90179) 1 NC_003155.4 mycinamicin resistance protein homolog; rRNA methyltransferase 90179 1211831 SAV_80 Streptomyces avermitilis MA-4680 rRNA methyltransferase NP_821254.1 89844 R 227882 CDS NP_821255.1 29826621 1211832 complement(90422..91192) 1 NC_003155.4 PF01522: Polysaccharide deacetylase; oligosaccharide deacetylase 91192 1211832 SAV_81 Streptomyces avermitilis MA-4680 oligosaccharide deacetylase NP_821255.1 90422 R 227882 CDS NP_821256.1 29826622 1211833 complement(91736..92317) 1 NC_003155.4 TetR family transcriptional regulator 92317 1211833 SAV_82 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_821256.1 91736 R 227882 CDS NP_821257.1 29826623 1211834 92523..92741 1 NC_003155.4 hypothetical protein 92741 1211834 SAV_83 Streptomyces avermitilis MA-4680 hypothetical protein NP_821257.1 92523 D 227882 CDS NP_821258.1 29826624 1211835 complement(92939..94183) 1 NC_003155.4 PF05139: Erythromycin esterase; hypothetical protein 94183 1211835 SAV_84 Streptomyces avermitilis MA-4680 hypothetical protein NP_821258.1 92939 R 227882 CDS NP_821259.1 29826625 1211836 94242..95009 1 NC_003155.4 MerR family transcriptional regulator 95009 1211836 SAV_85 Streptomyces avermitilis MA-4680 MerR family transcriptional regulator NP_821259.1 94242 D 227882 CDS NP_821260.1 29826626 1211837 complement(95110..96105) 1 NC_003155.4 LuxR-family transcriptional regulatory protein; erythropoiesis-stimulating protein 96105 1211837 SAV_86 Streptomyces avermitilis MA-4680 erythropoiesis-stimulating protein NP_821260.1 95110 R 227882 CDS NP_821261.1 29826627 1211838 96235..96567 1 NC_003155.4 hypothetical protein 96567 1211838 SAV_87 Streptomyces avermitilis MA-4680 hypothetical protein NP_821261.1 96235 D 227882 CDS NP_821262.1 29826628 1211839 complement(99274..100050) 1 NC_003155.4 PF00125: Core histone H2A/H2B/H3/H4; hypothetical protein 100050 1211839 SAV_88 Streptomyces avermitilis MA-4680 hypothetical protein NP_821262.1 99274 R 227882 CDS NP_821263.1 29826629 1211840 complement(100279..100866) 1 NC_003155.4 PF03752: Short repeats of unknown function; hypothetical protein 100866 1211840 SAV_89 Streptomyces avermitilis MA-4680 hypothetical protein NP_821263.1 100279 R 227882 CDS NP_821264.1 29826630 1211841 100955..101362 1 NC_003155.4 hydrolase 101362 1211841 SAV_90 Streptomyces avermitilis MA-4680 hydrolase NP_821264.1 100955 D 227882 CDS NP_821265.1 29826631 1211842 101447..101893 1 NC_003155.4 hypothetical protein 101893 1211842 SAV_91 Streptomyces avermitilis MA-4680 hypothetical protein NP_821265.1 101447 D 227882 CDS NP_821266.1 29826632 1211843 102549..103163 1 NC_003155.4 PF04203: Sortase family; lipoprotein 103163 1211843 SAV_92 Streptomyces avermitilis MA-4680 lipoprotein NP_821266.1 102549 D 227882 CDS NP_821267.1 29826633 1210018 103255..103746 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 103746 sig2 1210018 sig2 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_821267.1 103255 D 227882 CDS NP_821268.1 29826634 1211844 103709..104197 1 NC_003155.4 hypothetical protein 104197 1211844 SAV_94 Streptomyces avermitilis MA-4680 hypothetical protein NP_821268.1 103709 D 227882 CDS NP_821269.1 29826635 1211845 104696..106234 1 NC_003155.4 protein 106234 1211845 SAV_95 Streptomyces avermitilis MA-4680 protein NP_821269.1 104696 D 227882 CDS NP_821270.1 29826636 1211846 106628..107440 1 NC_003155.4 hypothetical protein 107440 1211846 SAV_96 Streptomyces avermitilis MA-4680 hypothetical protein NP_821270.1 106628 D 227882 CDS NP_821271.1 29826637 1211847 complement(107491..108027) 1 NC_003155.4 hypothetical protein 108027 1211847 SAV_97 Streptomyces avermitilis MA-4680 hypothetical protein NP_821271.1 107491 R 227882 CDS NP_821272.1 29826638 1211848 complement(108349..110238) 1 NC_003155.4 PF00723: Glycosyl hydrolases family 15; glycosyl hydrolase 110238 1211848 SAV_98 Streptomyces avermitilis MA-4680 glycosyl hydrolase NP_821272.1 108349 R 227882 CDS NP_821273.1 29826639 1211849 110830..113364 1 NC_003155.4 PF03176: MMPL family; integral membrane protein 113364 1211849 SAV_99 Streptomyces avermitilis MA-4680 integral membrane protein NP_821273.1 110830 D 227882 CDS NP_821274.1 29826640 1211850 113361..114866 1 NC_003155.4 pks11; polyketide synthase 114866 pks11-1 1211850 pks11-1 Streptomyces avermitilis MA-4680 polyketide synthase NP_821274.1 113361 D 227882 CDS NP_821275.1 29826641 1211851 114860..118594 1 NC_003155.4 pks11 containing aminotransferase domain; polyketide synthase 118594 pks11-2 1211851 pks11-2 Streptomyces avermitilis MA-4680 polyketide synthase NP_821275.1 114860 D 227882 CDS NP_821276.1 29826642 1211852 complement(118868..119221) 1 NC_003155.4 hypothetical protein 119221 1211852 SAV_102 Streptomyces avermitilis MA-4680 hypothetical protein NP_821276.1 118868 R 227882 CDS NP_821277.1 29826643 1211853 119461..120039 1 NC_003155.4 IS256 family transposase 120039 1211853 SAV_103 Streptomyces avermitilis MA-4680 IS256 family transposase NP_821277.1 119461 D 227882 CDS NP_821278.1 29826644 1211854 120102..120611 1 NC_003155.4 IS256 family, partial; IS256 family transposase 120611 1211854 SAV_104 Streptomyces avermitilis MA-4680 IS256 family transposase NP_821278.1 120102 D 227882 CDS NP_821279.1 29826645 1211855 complement(121935..122162) 1 NC_003155.4 hypothetical protein 122162 1211855 SAV_105 Streptomyces avermitilis MA-4680 hypothetical protein NP_821279.1 121935 R 227882 CDS NP_821280.1 29826646 1211856 123637..124200 1 NC_003155.4 hypothetical protein 124200 1211856 SAV_106 Streptomyces avermitilis MA-4680 hypothetical protein NP_821280.1 123637 D 227882 CDS NP_821281.1 29826647 1211857 124557..124883 1 NC_003155.4 hypothetical protein 124883 1211857 SAV_107 Streptomyces avermitilis MA-4680 hypothetical protein NP_821281.1 124557 D 227882 CDS NP_821282.1 29826648 1211858 124945..125364 1 NC_003155.4 hypothetical protein 125364 1211858 SAV_108 Streptomyces avermitilis MA-4680 hypothetical protein NP_821282.1 124945 D 227882 CDS NP_821283.1 29826649 1210019 125995..127230 1 NC_003155.4 CYP154A2; cytochrome P450 hydroxylase 127230 cyp1 1210019 cyp1 Streptomyces avermitilis MA-4680 cytochrome P450 hydroxylase NP_821283.1 125995 D 227882 CDS NP_821284.1 29826650 1211859 127243..128214 1 NC_003155.4 IS112 homolog; transposase 128214 1211859 SAV_110 Streptomyces avermitilis MA-4680 transposase NP_821284.1 127243 D 227882 CDS NP_821285.1 29826651 1211860 complement(128414..128743) 1 NC_003155.4 LuxR family transcriptional regulator 128743 1211860 SAV_111 Streptomyces avermitilis MA-4680 LuxR family transcriptional regulator NP_821285.1 128414 R 227882 CDS NP_821286.1 29826652 1211861 129497..132031 1 NC_003155.4 PF01590: GAF domain; hypothetical protein 132031 1211861 SAV_112 Streptomyces avermitilis MA-4680 hypothetical protein NP_821286.1 129497 D 227882 CDS NP_821287.1 29826653 1211862 132082..132333 1 NC_003155.4 hypothetical protein 132333 1211862 SAV_113 Streptomyces avermitilis MA-4680 hypothetical protein NP_821287.1 132082 D 227882 CDS NP_821288.1 29826654 1211863 132479..133000 1 NC_003155.4 IS6 family transposase 133000 1211863 SAV_114 Streptomyces avermitilis MA-4680 IS6 family transposase NP_821288.1 132479 D 227882 CDS NP_821289.1 29826655 1211864 132949..133668 1 NC_003155.4 IS6 family; IS6 family transposase 133668 1211864 SAV_115 Streptomyces avermitilis MA-4680 IS6 family transposase NP_821289.1 132949 D 227882 CDS NP_821290.1 29826656 1211865 133696..134031 1 NC_003155.4 hypothetical protein 134031 1211865 SAV_116 Streptomyces avermitilis MA-4680 hypothetical protein NP_821290.1 133696 D 227882 CDS NP_821291.1 29826657 1211866 134166..134822 1 NC_003155.4 hypothetical protein 134822 1211866 SAV_117 Streptomyces avermitilis MA-4680 hypothetical protein NP_821291.1 134166 D 227882 CDS NP_821292.1 29826658 1211867 136682..137041 1 NC_003155.4 IS1647-like transposase 137041 1211867 SAV_118 Streptomyces avermitilis MA-4680 IS1647-like transposase NP_821292.1 136682 D 227882 CDS NP_821293.2 57833848 1211868 136846..137490 1 NC_003155.4 IS1647-like transposase 137490 1211868 SAV_119 Streptomyces avermitilis MA-4680 IS1647-like transposase NP_821293.2 136846 D 227882 CDS NP_821294.1 29826660 1211869 137556..138740 1 NC_003155.4 IS4 family transposase 138740 1211869 SAV_120 Streptomyces avermitilis MA-4680 IS4 family transposase NP_821294.1 137556 D 227882 CDS NP_821295.1 29826661 1211870 138932..139393 1 NC_003155.4 hypothetical protein 139393 1211870 SAV_121 Streptomyces avermitilis MA-4680 hypothetical protein NP_821295.1 138932 D 227882 CDS NP_821296.1 29826662 1211871 complement(139360..140565) 1 NC_003155.4 IS110 family transposase 140565 1211871 SAV_122 Streptomyces avermitilis MA-4680 IS110 family transposase NP_821296.1 139360 R 227882 CDS NP_821297.1 29826663 1211872 140787..141911 1 NC_003155.4 PF01135: Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT); O-methyltransferase 141911 1211872 SAV_123 Streptomyces avermitilis MA-4680 O-methyltransferase NP_821297.1 140787 D 227882 CDS NP_821298.1 29826664 1211873 complement(141787..142821) 1 NC_003155.4 hypothetical protein 142821 1211873 SAV_124 Streptomyces avermitilis MA-4680 hypothetical protein NP_821298.1 141787 R 227882 CDS NP_821299.1 29826665 1211874 142975..143661 1 NC_003155.4 PF00597: DedA family; hypothetical protein 143661 1211874 SAV_125 Streptomyces avermitilis MA-4680 hypothetical protein NP_821299.1 142975 D 227882 CDS NP_821300.1 29826666 1211875 143658..144263 1 NC_003155.4 PF01569: PAP2 superfamily; integral membrane protein 144263 1211875 SAV_126 Streptomyces avermitilis MA-4680 integral membrane protein NP_821300.1 143658 D 227882 CDS NP_821301.1 29826667 1211876 144260..144988 1 NC_003155.4 PF01569: PAP2 superfamily; hypothetical protein 144988 1211876 SAV_127 Streptomyces avermitilis MA-4680 hypothetical protein NP_821301.1 144260 D 227882 CDS NP_821302.1 29826668 1211877 144942..145604 1 NC_003155.4 two-component system response regulator 145604 1211877 SAV_128 Streptomyces avermitilis MA-4680 two-component system response regulator NP_821302.1 144942 D 227882 CDS NP_821303.1 29826669 1211878 145601..146962 1 NC_003155.4 two-component system sensor kinase 146962 1211878 SAV_129 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_821303.1 145601 D 227882 CDS NP_821304.1 29826670 1211879 complement(146943..147743) 1 NC_003155.4 PF03988: Repeat of Unknown Function (DUF347); integral membrane protein 147743 1211879 SAV_130 Streptomyces avermitilis MA-4680 integral membrane protein NP_821304.1 146943 R 227882 CDS NP_821305.1 29826671 1211880 complement(147993..148823) 1 NC_003155.4 PF03988: Repeat of Unknown Function (DUF347); integral membrane protein 148823 1211880 SAV_131 Streptomyces avermitilis MA-4680 integral membrane protein NP_821305.1 147993 R 227882 CDS NP_821306.1 29826672 1211881 148993..149274 1 NC_003155.4 hypothetical protein 149274 1211881 SAV_132 Streptomyces avermitilis MA-4680 hypothetical protein NP_821306.1 148993 D 227882 CDS NP_821307.1 29826673 1211882 149373..150071 1 NC_003155.4 transporter 150071 1211882 SAV_133 Streptomyces avermitilis MA-4680 transporter NP_821307.1 149373 D 227882 CDS NP_821308.1 29826674 1211883 complement(150032..151414) 1 NC_003155.4 two-component system sensor kinase 151414 1211883 SAV_134 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_821308.1 150032 R 227882 CDS NP_821309.1 29826675 1211884 151606..152274 1 NC_003155.4 lipoprotein 152274 1211884 SAV_135 Streptomyces avermitilis MA-4680 lipoprotein NP_821309.1 151606 D 227882 CDS NP_821310.1 29826676 1211885 152278..153018 1 NC_003155.4 ABC transporter ATP-binding protein 153018 1211885 SAV_136 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_821310.1 152278 D 227882 CDS NP_821311.1 29826677 1211886 153005..153718 1 NC_003155.4 ABC transporter ATP-binding protein 153718 1211886 SAV_137 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_821311.1 153005 D 227882 CDS NP_821312.1 29826678 1211887 153715..156363 1 NC_003155.4 PF02687: Predicted permease; ABC transporter permease 156363 1211887 SAV_138 Streptomyces avermitilis MA-4680 ABC transporter permease NP_821312.1 153715 D 227882 CDS NP_821313.1 29826679 1211888 156360..157139 1 NC_003155.4 two-component system response regulator 157139 1211888 SAV_139 Streptomyces avermitilis MA-4680 two-component system response regulator NP_821313.1 156360 D 227882 CDS NP_821314.1 29826680 1211889 complement(157954..158928) 1 NC_003155.4 hydroxylase 158928 1211889 SAV_140 Streptomyces avermitilis MA-4680 hydroxylase NP_821314.1 157954 R 227882 CDS NP_821315.1 29826681 1211890 complement(158997..160031) 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; epoxide hydrolase 160031 ephA1 1211890 ephA1 Streptomyces avermitilis MA-4680 epoxide hydrolase NP_821315.1 158997 R 227882 CDS NP_821316.1 29826682 1211891 complement(160053..160754) 1 NC_003155.4 PF00106: short chain dehydrogenase; short chain dehydrogenase 160754 1211891 SAV_142 Streptomyces avermitilis MA-4680 short chain dehydrogenase NP_821316.1 160053 R 227882 CDS NP_821317.1 29826683 1211892 complement(161392..161961) 1 NC_003155.4 TetR family transcriptional regulator 161961 1211892 SAV_143 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_821317.1 161392 R 227882 CDS NP_821318.1 29826684 1211893 complement(162195..163493) 1 NC_003155.4 PF01061: ABC-2 type transporter; hypothetical protein 163493 1211893 SAV_144 Streptomyces avermitilis MA-4680 hypothetical protein NP_821318.1 162195 R 227882 CDS NP_821319.1 29826685 1211894 complement(163767..165950) 1 NC_003155.4 PF03176: MMPL family; membrane tranport protein 165950 1211894 SAV_145 Streptomyces avermitilis MA-4680 membrane tranport protein NP_821319.1 163767 R 227882 CDS NP_821320.1 29826686 1211895 166102..166851 1 NC_003155.4 TetR family transcriptional regulator 166851 1211895 SAV_146 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_821320.1 166102 D 227882 CDS NP_821321.1 29826687 1211896 167014..167367 1 NC_003155.4 hypothetical protein 167367 1211896 SAV_147 Streptomyces avermitilis MA-4680 hypothetical protein NP_821321.1 167014 D 227882 CDS NP_821322.1 29826688 1211897 complement(167757..168923) 1 NC_003155.4 PF03022: Major royal jelly protein; hypothetical protein 168923 1211897 SAV_148 Streptomyces avermitilis MA-4680 hypothetical protein NP_821322.1 167757 R 227882 CDS NP_821323.1 29826689 1211898 complement(169217..169735) 1 NC_003155.4 hypothetical protein 169735 1211898 SAV_149 Streptomyces avermitilis MA-4680 hypothetical protein NP_821323.1 169217 R 227882 CDS NP_821324.1 29826690 1211899 complement(169801..170613) 1 NC_003155.4 PF00106: short chain dehydrogenase; short chain dehydrogenase 170613 1211899 SAV_150 Streptomyces avermitilis MA-4680 short chain dehydrogenase NP_821324.1 169801 R 227882 CDS NP_821325.1 29826691 1211900 complement(171402..172043) 1 NC_003155.4 TetR family transcriptional regulator 172043 1211900 SAV_151 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_821325.1 171402 R 227882 CDS NP_821326.1 29826692 1211901 172191..173102 1 NC_003155.4 PF00106: short chain dehydrogenase; short chain dehydrogenase 173102 1211901 SAV_152 Streptomyces avermitilis MA-4680 short chain dehydrogenase NP_821326.1 172191 D 227882 CDS NP_821327.1 29826693 1211902 173107..174243 1 NC_003155.4 hypothetical protein 174243 1211902 SAV_153 Streptomyces avermitilis MA-4680 hypothetical protein NP_821327.1 173107 D 227882 CDS NP_821328.1 29826694 1211903 174240..175163 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 175163 1211903 SAV_154 Streptomyces avermitilis MA-4680 hydrolase NP_821328.1 174240 D 227882 CDS NP_821329.1 29826695 1211904 175255..176166 1 NC_003155.4 hypothetical protein 176166 1211904 SAV_155 Streptomyces avermitilis MA-4680 hypothetical protein NP_821329.1 175255 D 227882 CDS NP_821330.1 29826696 1211905 176190..177290 1 NC_003155.4 PF00111: 2Fe-2S iron-sulfur cluster binding domain; iron-sulfur oxidoreductase 177290 1211905 SAV_156 Streptomyces avermitilis MA-4680 iron-sulfur oxidoreductase NP_821330.1 176190 D 227882 CDS NP_821331.1 29826697 1211906 complement(177538..179952) 1 NC_003155.4 PF06827: Zinc finger found in FPG and IleRS; hypothetical protein 179952 1211906 SAV_157 Streptomyces avermitilis MA-4680 hypothetical protein NP_821331.1 177538 R 227882 CDS NP_821332.1 29826698 1211907 complement(179949..180287) 1 NC_003155.4 hypothetical protein 180287 1211907 SAV_158 Streptomyces avermitilis MA-4680 hypothetical protein NP_821332.1 179949 R 227882 CDS NP_821333.1 29826699 1211908 complement(180284..181426) 1 NC_003155.4 PF00589: Phage integrase family; integrase/recombinase 181426 int1 1211908 int1 Streptomyces avermitilis MA-4680 integrase/recombinase NP_821333.1 180284 R 227882 CDS NP_821334.1 29826700 1211909 181802..182389 1 NC_003155.4 hypothetical protein 182389 1211909 SAV_160 Streptomyces avermitilis MA-4680 hypothetical protein NP_821334.1 181802 D 227882 CDS NP_821335.1 29826701 1211910 182430..182948 1 NC_003155.4 hypothetical protein 182948 1211910 SAV_161 Streptomyces avermitilis MA-4680 hypothetical protein NP_821335.1 182430 D 227882 CDS NP_821336.1 29826702 1211911 182945..183952 1 NC_003155.4 hypothetical protein 183952 1211911 SAV_162 Streptomyces avermitilis MA-4680 hypothetical protein NP_821336.1 182945 D 227882 CDS NP_821337.1 29826703 1211912 184316..184795 1 NC_003155.4 hypothetical protein 184795 1211912 SAV_163 Streptomyces avermitilis MA-4680 hypothetical protein NP_821337.1 184316 D 227882 CDS NP_821338.1 29826704 1211913 complement(185138..185368) 1 NC_003155.4 hypothetical protein 185368 1211913 SAV_164 Streptomyces avermitilis MA-4680 hypothetical protein NP_821338.1 185138 R 227882 CDS NP_821339.1 29826705 1211914 185890..186507 1 NC_003155.4 hypothetical protein 186507 1211914 SAV_165 Streptomyces avermitilis MA-4680 hypothetical protein NP_821339.1 185890 D 227882 CDS NP_821340.1 29826706 1211915 186549..186905 1 NC_003155.4 hypothetical protein 186905 1211915 SAV_166 Streptomyces avermitilis MA-4680 hypothetical protein NP_821340.1 186549 D 227882 CDS NP_821341.1 29826707 1211916 187026..187742 1 NC_003155.4 hypothetical protein 187742 1211916 SAV_167 Streptomyces avermitilis MA-4680 hypothetical protein NP_821341.1 187026 D 227882 CDS NP_821342.1 29826708 1211917 188180..189094 1 NC_003155.4 hypothetical protein 189094 1211917 SAV_168 Streptomyces avermitilis MA-4680 hypothetical protein NP_821342.1 188180 D 227882 CDS NP_821343.1 29826709 1211918 complement(188910..189866) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; hypothetical protein 189866 1211918 SAV_169 Streptomyces avermitilis MA-4680 hypothetical protein NP_821343.1 188910 R 227882 CDS NP_821344.1 29826710 1211919 complement(190026..191453) 1 NC_003155.4 hypothetical protein 191453 1211919 SAV_170 Streptomyces avermitilis MA-4680 hypothetical protein NP_821344.1 190026 R 227882 CDS NP_821345.1 29826711 1211920 complement(191479..192900) 1 NC_003155.4 hypothetical protein 192900 1211920 SAV_171 Streptomyces avermitilis MA-4680 hypothetical protein NP_821345.1 191479 R 227882 CDS NP_821346.1 29826712 1211921 193615..194553 1 NC_003155.4 hypothetical protein 194553 1211921 SAV_172 Streptomyces avermitilis MA-4680 hypothetical protein NP_821346.1 193615 D 227882 CDS NP_821347.1 29826713 1211922 194571..194891 1 NC_003155.4 hypothetical protein 194891 1211922 SAV_173 Streptomyces avermitilis MA-4680 hypothetical protein NP_821347.1 194571 D 227882 CDS NP_821348.1 29826714 1211923 194888..195463 1 NC_003155.4 hypothetical protein 195463 1211923 SAV_174 Streptomyces avermitilis MA-4680 hypothetical protein NP_821348.1 194888 D 227882 CDS NP_821349.1 29826715 1211924 195460..198141 1 NC_003155.4 ATP/GTP-binding protein 198141 1211924 SAV_175 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_821349.1 195460 D 227882 CDS NP_821350.1 29826716 1211925 198138..198488 1 NC_003155.4 hypothetical protein 198488 1211925 SAV_176 Streptomyces avermitilis MA-4680 hypothetical protein NP_821350.1 198138 D 227882 CDS NP_821351.1 29826717 1211926 198490..201222 1 NC_003155.4 PF01970: Integral membrane protein DUF112; hypothetical protein 201222 1211926 SAV_177 Streptomyces avermitilis MA-4680 hypothetical protein NP_821351.1 198490 D 227882 CDS NP_821352.1 29826718 1211927 201219..202370 1 NC_003155.4 Seems to have a cleavable N-term signal sequence; NLP/P60-family protein 202370 1211927 SAV_178 Streptomyces avermitilis MA-4680 NLP/P60-family protein NP_821352.1 201219 D 227882 CDS NP_821353.1 29826719 1211928 202367..203014 1 NC_003155.4 hypothetical protein 203014 1211928 SAV_179 Streptomyces avermitilis MA-4680 hypothetical protein NP_821353.1 202367 D 227882 CDS NP_821354.1 29826720 1211929 203056..205614 1 NC_003155.4 ATP/GTP-binding protein 205614 1211929 SAV_180 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_821354.1 203056 D 227882 CDS NP_821355.1 29826721 1211930 205611..206525 1 NC_003155.4 hypothetical protein 206525 1211930 SAV_181 Streptomyces avermitilis MA-4680 hypothetical protein NP_821355.1 205611 D 227882 CDS NP_821356.1 29826722 1211931 207837..208697 1 NC_003155.4 hypothetical protein 208697 1211931 SAV_182 Streptomyces avermitilis MA-4680 hypothetical protein NP_821356.1 207837 D 227882 CDS NP_821357.1 29826723 1211932 208719..209423 1 NC_003155.4 hypothetical protein 209423 1211932 SAV_183 Streptomyces avermitilis MA-4680 hypothetical protein NP_821357.1 208719 D 227882 CDS NP_821358.1 29826724 1211933 209423..210250 1 NC_003155.4 hypothetical protein 210250 1211933 SAV_184 Streptomyces avermitilis MA-4680 hypothetical protein NP_821358.1 209423 D 227882 CDS NP_821359.1 29826725 1211934 210240..211733 1 NC_003155.4 PF00437: Type II/IV secretion system protein; ATP/GTP-binding protein 211733 1211934 SAV_185 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_821359.1 210240 D 227882 CDS NP_821360.1 29826726 1211935 211730..212659 1 NC_003155.4 PF00482: Bacterial type II secretion system protein F domain; integral membrane protein 212659 1211935 SAV_186 Streptomyces avermitilis MA-4680 integral membrane protein NP_821360.1 211730 D 227882 CDS NP_821361.1 29826727 1211936 212678..213562 1 NC_003155.4 PF00482: Bacterial type II secretion system protein F domain; integral membrane protein 213562 1211936 SAV_187 Streptomyces avermitilis MA-4680 integral membrane protein NP_821361.1 212678 D 227882 CDS NP_821362.1 29826728 1211937 213608..213823 1 NC_003155.4 hypothetical protein 213823 1211937 SAV_188 Streptomyces avermitilis MA-4680 hypothetical protein NP_821362.1 213608 D 227882 CDS NP_821363.1 29826729 1211938 213820..214248 1 NC_003155.4 hypothetical protein 214248 1211938 SAV_189 Streptomyces avermitilis MA-4680 hypothetical protein NP_821363.1 213820 D 227882 CDS NP_821364.1 29826730 1211939 214245..214706 1 NC_003155.4 hypothetical protein 214706 1211939 SAV_190 Streptomyces avermitilis MA-4680 hypothetical protein NP_821364.1 214245 D 227882 CDS NP_821365.1 29826731 1211940 214706..215158 1 NC_003155.4 hypothetical protein 215158 1211940 SAV_191 Streptomyces avermitilis MA-4680 hypothetical protein NP_821365.1 214706 D 227882 CDS NP_821366.1 29826732 1211941 215158..218625 1 NC_003155.4 PF01476: LysM domain; hypothetical protein 218625 1211941 SAV_192 Streptomyces avermitilis MA-4680 hypothetical protein NP_821366.1 215158 D 227882 CDS NP_821367.1 29826733 1211942 218903..220732 1 NC_003155.4 hypothetical protein 220732 1211942 SAV_193 Streptomyces avermitilis MA-4680 hypothetical protein NP_821367.1 218903 D 227882 CDS NP_821368.1 29826734 1211943 complement(220848..221402) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 221402 1211943 SAV_194 Streptomyces avermitilis MA-4680 acetyltransferase NP_821368.1 220848 R 227882 CDS NP_821369.1 29826735 1211944 complement(221399..222835) 1 NC_003155.4 PF06036: Streptomyces protein of unknown function (DUF921); hypothetical protein 222835 1211944 SAV_195 Streptomyces avermitilis MA-4680 hypothetical protein NP_821369.1 221399 R 227882 CDS NP_821370.1 29826736 1211945 222871..224691 1 NC_003155.4 PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; hypothetical protein 224691 1211945 SAV_196 Streptomyces avermitilis MA-4680 hypothetical protein NP_821370.1 222871 D 227882 CDS NP_821371.1 29826737 1211946 225238..226227 1 NC_003155.4 hypothetical protein 226227 1211946 SAV_197 Streptomyces avermitilis MA-4680 hypothetical protein NP_821371.1 225238 D 227882 CDS NP_821372.1 29826738 1211947 226312..227820 1 NC_003155.4 amino acid/metabolite permease 227820 1211947 SAV_198 Streptomyces avermitilis MA-4680 amino acid/metabolite permease NP_821372.1 226312 D 227882 CDS NP_821373.1 29826739 1211948 227817..228737 1 NC_003155.4 glutamine synthetase 228737 1211948 SAV_199 Streptomyces avermitilis MA-4680 glutamine synthetase NP_821373.1 227817 D 227882 CDS NP_821374.1 29826740 1211949 complement(229825..236937) 1 NC_003155.4 PF05593: RHS Repeat; large protein 236937 1211949 SAV_200 Streptomyces avermitilis MA-4680 large protein NP_821374.1 229825 R 227882 CDS NP_821375.1 29826741 1211950 237437..237682 1 NC_003155.4 hypothetical protein 237682 1211950 SAV_201 Streptomyces avermitilis MA-4680 hypothetical protein NP_821375.1 237437 D 227882 CDS NP_821376.1 29826742 1211951 complement(237840..238601) 1 NC_003155.4 hypothetical protein 238601 1211951 SAV_202 Streptomyces avermitilis MA-4680 hypothetical protein NP_821376.1 237840 R 227882 CDS NP_821377.1 29826743 1211952 complement(239037..239462) 1 NC_003155.4 hypothetical protein 239462 1211952 SAV_203 Streptomyces avermitilis MA-4680 hypothetical protein NP_821377.1 239037 R 227882 CDS NP_821378.1 29826744 1211953 complement(239788..240234) 1 NC_003155.4 hypothetical protein 240234 1211953 SAV_204 Streptomyces avermitilis MA-4680 hypothetical protein NP_821378.1 239788 R 227882 CDS NP_821379.1 29826745 1211954 240325..240903 1 NC_003155.4 TetR family transcriptional regulator 240903 1211954 SAV_205 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_821379.1 240325 D 227882 CDS NP_821380.1 29826746 1211955 complement(241742..241966) 1 NC_003155.4 Tn4561 family, truncated; Tn4561 family transposase 241966 1211955 SAV_206 Streptomyces avermitilis MA-4680 Tn4561 family transposase NP_821380.1 241742 R 227882 CDS NP_821381.1 29826747 1211956 complement(241989..242195) 1 NC_003155.4 truncated; transposase 242195 1211956 SAV_207 Streptomyces avermitilis MA-4680 transposase NP_821381.1 241989 R 227882 CDS NP_821382.1 29826748 1211957 complement(242908..243411) 1 NC_003155.4 IstB-like ATP-binding protein 243411 1211957 SAV_208 Streptomyces avermitilis MA-4680 IstB-like ATP-binding protein NP_821382.1 242908 R 227882 CDS NP_821383.1 29826749 1211958 complement(243581..244771) 1 NC_003155.4 IS110 family transposase 244771 1211958 SAV_209 Streptomyces avermitilis MA-4680 IS110 family transposase NP_821383.1 243581 R 227882 CDS NP_821384.1 29826750 1211959 complement(245081..246040) 1 NC_003155.4 regulatory protein 246040 1211959 SAV_210 Streptomyces avermitilis MA-4680 regulatory protein NP_821384.1 245081 R 227882 CDS NP_821385.1 29826751 1211960 complement(246027..246653) 1 NC_003155.4 hypothetical protein 246653 1211960 SAV_211 Streptomyces avermitilis MA-4680 hypothetical protein NP_821385.1 246027 R 227882 CDS NP_821386.1 29826752 1211961 complement(247471..248142) 1 NC_003155.4 hypothetical protein 248142 1211961 SAV_212 Streptomyces avermitilis MA-4680 hypothetical protein NP_821386.1 247471 R 227882 CDS NP_821387.1 29826753 1211962 complement(248139..248741) 1 NC_003155.4 probably pseudogene; ECF subfamily RNA polymerase sigma factor 248741 sig60 1211962 sig60 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_821387.1 248139 R 227882 CDS NP_821388.1 29826754 1211963 complement(249173..249661) 1 NC_003155.4 hypothetical protein 249661 1211963 SAV_214 Streptomyces avermitilis MA-4680 hypothetical protein NP_821388.1 249173 R 227882 CDS NP_821389.1 29826755 1211964 complement(249733..253416) 1 NC_003155.4 PF05729: NACHT domain; hypothetical protein 253416 1211964 SAV_215 Streptomyces avermitilis MA-4680 hypothetical protein NP_821389.1 249733 R 227882 CDS NP_821390.1 29826756 1211965 complement(254011..254895) 1 NC_003155.4 PF03819: MazG nucleotide pyrophosphohydrolase domain; pyrophosphatase 254895 1211965 SAV_216 Streptomyces avermitilis MA-4680 pyrophosphatase NP_821390.1 254011 R 227882 CDS NP_821391.1 29826757 1211966 255013..255273 1 NC_003155.4 PF00550: Phosphopantetheine attachment site; ACP 255273 fabC4 1211966 fabC4 Streptomyces avermitilis MA-4680 ACP NP_821391.1 255013 D 227882 CDS NP_821392.1 29826758 1211967 255270..255677 1 NC_003155.4 transcriptional regulator 255677 1211967 SAV_218 Streptomyces avermitilis MA-4680 transcriptional regulator NP_821392.1 255270 D 227882 CDS NP_821393.1 29826759 1211968 255674..256570 1 NC_003155.4 PF06114 :Domain of unknown function (DUF955); hypothetical protein 256570 1211968 SAV_219 Streptomyces avermitilis MA-4680 hypothetical protein NP_821393.1 255674 D 227882 CDS NP_821394.1 29826760 1211969 256598..257401 1 NC_003155.4 hypothetical protein 257401 1211969 SAV_220 Streptomyces avermitilis MA-4680 hypothetical protein NP_821394.1 256598 D 227882 CDS NP_821395.1 29826761 1211970 complement(257443..258474) 1 NC_003155.4 hypothetical protein 258474 1211970 SAV_221 Streptomyces avermitilis MA-4680 hypothetical protein NP_821395.1 257443 R 227882 CDS NP_821396.1 29826762 1211971 258522..258809 1 NC_003155.4 hypothetical protein 258809 1211971 SAV_222 Streptomyces avermitilis MA-4680 hypothetical protein NP_821396.1 258522 D 227882 CDS NP_821397.1 29826763 1211972 260024..261079 1 NC_003155.4 PF03457: Helicase associated domain; DNA-binding protein 261079 1211972 SAV_223 Streptomyces avermitilis MA-4680 DNA-binding protein NP_821397.1 260024 D 227882 CDS NP_821398.1 29826764 1211973 261139..262191 1 NC_003155.4 hypothetical protein 262191 1211973 SAV_224 Streptomyces avermitilis MA-4680 hypothetical protein NP_821398.1 261139 D 227882 CDS NP_821399.1 29826765 1211974 complement(263244..264521) 1 NC_003155.4 IS6120-like transposase 264521 1211974 SAV_225 Streptomyces avermitilis MA-4680 IS6120-like transposase NP_821399.1 263244 R 227882 CDS NP_821400.1 29826766 1211975 complement(264551..266317) 1 NC_003155.4 PF00078: Reverse transcriptase (RNA-dependent DNA polymerase); reverse transcriptase 266317 1211975 SAV_226 Streptomyces avermitilis MA-4680 reverse transcriptase NP_821400.1 264551 R 227882 CDS NP_821401.1 29826767 1211976 266680..268044 1 NC_003155.4 similar to IS 4-family transposase; transposase 268044 1211976 SAV_227 Streptomyces avermitilis MA-4680 transposase NP_821401.1 266680 D 227882 CDS NP_821402.1 29826768 1211977 268251..269444 1 NC_003155.4 hypothetical protein 269444 1211977 SAV_228 Streptomyces avermitilis MA-4680 hypothetical protein NP_821402.1 268251 D 227882 CDS NP_821403.1 29826769 1211978 269776..270012 1 NC_003155.4 transposase 270012 1211978 SAV_229 Streptomyces avermitilis MA-4680 transposase NP_821403.1 269776 D 227882 CDS NP_821404.1 29826770 1211979 complement(270055..271758) 1 NC_003155.4 PF05935: Arylsulfotransferase (ASST); hypothetical protein 271758 1211979 SAV_230 Streptomyces avermitilis MA-4680 hypothetical protein NP_821404.1 270055 R 227882 CDS NP_821405.1 29826771 1211980 complement(272429..273277) 1 NC_003155.4 MerR family transcriptional regulator 273277 1211980 SAV_231 Streptomyces avermitilis MA-4680 MerR family transcriptional regulator NP_821405.1 272429 R 227882 CDS NP_821406.1 29826772 1211981 complement(273444..273962) 1 NC_003155.4 hypothetical protein 273962 1211981 SAV_232 Streptomyces avermitilis MA-4680 hypothetical protein NP_821406.1 273444 R 227882 CDS NP_821407.1 29826773 1211982 complement(274210..274494) 1 NC_003155.4 hypothetical protein 274494 1211982 SAV_233 Streptomyces avermitilis MA-4680 hypothetical protein NP_821407.1 274210 R 227882 CDS NP_821408.1 29826774 1211983 complement(274689..275168) 1 NC_003155.4 PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; regulatory protein 275168 1211983 SAV_234 Streptomyces avermitilis MA-4680 regulatory protein NP_821408.1 274689 R 227882 CDS NP_821409.1 29826775 1211984 275233..275721 1 NC_003155.4 PF01740: STAS domain; anti-sigma factor antagonist 275721 1211984 SAV_235 Streptomyces avermitilis MA-4680 anti-sigma factor antagonist NP_821409.1 275233 D 227882 CDS NP_821410.1 29826776 1211985 275872..276393 1 NC_003155.4 hypothetical protein 276393 1211985 SAV_236 Streptomyces avermitilis MA-4680 hypothetical protein NP_821410.1 275872 D 227882 CDS NP_821411.1 29826777 1211986 276877..278016 1 NC_003155.4 DNA-binding protein 278016 1211986 SAV_237 Streptomyces avermitilis MA-4680 DNA-binding protein NP_821411.1 276877 D 227882 CDS NP_821412.1 29826778 1211987 278037..278444 1 NC_003155.4 DNA-binding protein 278444 1211987 SAV_238 Streptomyces avermitilis MA-4680 DNA-binding protein NP_821412.1 278037 D 227882 CDS NP_821413.1 29826779 1211988 complement(278470..279057) 1 NC_003155.4 hypothetical protein 279057 1211988 SAV_239 Streptomyces avermitilis MA-4680 hypothetical protein NP_821413.1 278470 R 227882 CDS NP_821414.1 29826780 1211989 complement(279267..279635) 1 NC_003155.4 hypothetical protein 279635 1211989 SAV_240 Streptomyces avermitilis MA-4680 hypothetical protein NP_821414.1 279267 R 227882 CDS NP_821415.1 29826781 1211990 complement(279644..279919) 1 NC_003155.4 PF03869: Arc-like DNA binding domain; hypothetical protein 279919 1211990 SAV_241 Streptomyces avermitilis MA-4680 hypothetical protein NP_821415.1 279644 R 227882 CDS NP_821416.1 29826782 1211991 complement(280342..280782) 1 NC_003155.4 hypothetical protein 280782 1211991 SAV_242 Streptomyces avermitilis MA-4680 hypothetical protein NP_821416.1 280342 R 227882 CDS NP_821417.1 29826783 1211992 complement(281208..281585) 1 NC_003155.4 hypothetical protein 281585 1211992 SAV_243 Streptomyces avermitilis MA-4680 hypothetical protein NP_821417.1 281208 R 227882 CDS NP_821418.1 29826784 1211993 281928..282242 1 NC_003155.4 MerR family transcriptional regulator 282242 1211993 SAV_244 Streptomyces avermitilis MA-4680 MerR family transcriptional regulator NP_821418.1 281928 D 227882 CDS NP_821419.1 29826785 1211994 complement(282829..283503) 1 NC_003155.4 PF01810: LysE type translocator; LysE family efflux protein 283503 1211994 SAV_245 Streptomyces avermitilis MA-4680 LysE family efflux protein NP_821419.1 282829 R 227882 CDS NP_821420.1 29826786 1211995 complement(283694..284041) 1 NC_003155.4 hypothetical protein 284041 1211995 SAV_246 Streptomyces avermitilis MA-4680 hypothetical protein NP_821420.1 283694 R 227882 CDS NP_821421.1 29826787 1211996 284429..286645 1 NC_003155.4 PF05729: NACHT domain; hypothetical protein 286645 1211996 SAV_247 Streptomyces avermitilis MA-4680 hypothetical protein NP_821421.1 284429 D 227882 CDS NP_821422.1 29826788 1211997 complement(287461..287775) 1 NC_003155.4 hypothetical protein 287775 1211997 SAV_248 Streptomyces avermitilis MA-4680 hypothetical protein NP_821422.1 287461 R 227882 CDS NP_821423.1 29826789 1211998 complement(288173..288562) 1 NC_003155.4 hypothetical protein 288562 1211998 SAV_249 Streptomyces avermitilis MA-4680 hypothetical protein NP_821423.1 288173 R 227882 CDS NP_821424.1 29826790 1211999 288726..292160 1 NC_003155.4 PF00515: TPR Domain; hypothetical protein 292160 1211999 SAV_250 Streptomyces avermitilis MA-4680 hypothetical protein NP_821424.1 288726 D 227882 CDS NP_821425.1 29826791 1212000 complement(292968..293723) 1 NC_003155.4 PF02355: Protein export membrane protein; integral membrane protein 293723 1212000 SAV_251 Streptomyces avermitilis MA-4680 integral membrane protein NP_821425.1 292968 R 227882 CDS NP_821426.1 29826792 1212001 294014..294610 1 NC_003155.4 ABC transporter ATP-binding protein 294610 1212001 SAV_252 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_821426.1 294014 D 227882 CDS NP_821427.1 29826793 1212002 294912..295244 1 NC_003155.4 MutT-family protein 295244 1212002 SAV_253 Streptomyces avermitilis MA-4680 MutT-family protein NP_821427.1 294912 D 227882 CDS NP_821428.1 29826794 1212003 295675..296976 1 NC_003155.4 Tn5741 family, truncated; Tn5741 family transposase 296976 1212003 SAV_254 Streptomyces avermitilis MA-4680 Tn5741 family transposase NP_821428.1 295675 D 227882 CDS NP_821429.1 29826795 1212004 296991..298436 1 NC_003155.4 PF01433: Peptidase family M1; metallopeptidase 298436 1212004 SAV_255 Streptomyces avermitilis MA-4680 metallopeptidase NP_821429.1 296991 D 227882 CDS NP_821430.1 29826796 1212005 298664..299872 1 NC_003155.4 PF01609: Transposase DDE domain; transposase 299872 1212005 SAV_256 Streptomyces avermitilis MA-4680 transposase NP_821430.1 298664 D 227882 CDS NP_821431.1 29826797 1212006 complement(299873..300469) 1 NC_003155.4 ABC transporter ATP-binding protein 300469 1212006 SAV_257 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_821431.1 299873 R 227882 CDS NP_821432.1 29826798 1212007 complement(300882..301145) 1 NC_003155.4 hypothetical protein 301145 1212007 SAV_258 Streptomyces avermitilis MA-4680 hypothetical protein NP_821432.1 300882 R 227882 CDS NP_821433.1 29826799 1212008 complement(301142..303052) 1 NC_003155.4 asparagine synthetase 303052 asnH1 1212008 asnH1 Streptomyces avermitilis MA-4680 asparagine synthetase NP_821433.1 301142 R 227882 CDS NP_821434.1 29826800 1212009 303674..304072 1 NC_003155.4 transposase 304072 1212009 SAV_260 Streptomyces avermitilis MA-4680 transposase NP_821434.1 303674 D 227882 CDS NP_821435.1 29826801 1212010 304104..304334 1 NC_003155.4 hypothetical protein 304334 1212010 SAV_261 Streptomyces avermitilis MA-4680 hypothetical protein NP_821435.1 304104 D 227882 CDS NP_821436.1 29826802 1212011 304527..305000 1 NC_003155.4 hypothetical protein 305000 1212011 SAV_262 Streptomyces avermitilis MA-4680 hypothetical protein NP_821436.1 304527 D 227882 CDS NP_821437.1 29826803 1212012 complement(305311..306945) 1 NC_003155.4 IS6 family transposase 306945 1212012 SAV_263 Streptomyces avermitilis MA-4680 IS6 family transposase NP_821437.1 305311 R 227882 CDS NP_821438.1 29826804 1212013 complement(307092..309302) 1 NC_003155.4 hypothetical protein 309302 1212013 SAV_264 Streptomyces avermitilis MA-4680 hypothetical protein NP_821438.1 307092 R 227882 CDS NP_821439.1 29826805 1212014 309794..310207 1 NC_003155.4 hypothetical protein 310207 1212014 SAV_265 Streptomyces avermitilis MA-4680 hypothetical protein NP_821439.1 309794 D 227882 CDS NP_821440.1 29826806 1212015 complement(310455..311114) 1 NC_003155.4 hypothetical protein 311114 1212015 SAV_266 Streptomyces avermitilis MA-4680 hypothetical protein NP_821440.1 310455 R 227882 CDS NP_821441.1 29826807 1212016 311330..311680 1 NC_003155.4 hypothetical protein 311680 1212016 SAV_267 Streptomyces avermitilis MA-4680 hypothetical protein NP_821441.1 311330 D 227882 CDS NP_821442.1 29826808 1212017 complement(312030..312479) 1 NC_003155.4 hypothetical protein 312479 1212017 SAV_268 Streptomyces avermitilis MA-4680 hypothetical protein NP_821442.1 312030 R 227882 CDS NP_821443.1 29826809 1212018 complement(312589..314877) 1 NC_003155.4 hypothetical protein 314877 1212018 SAV_269 Streptomyces avermitilis MA-4680 hypothetical protein NP_821443.1 312589 R 227882 CDS NP_821444.1 29826810 1212019 315325..315852 1 NC_003155.4 hypothetical protein 315852 1212019 SAV_270 Streptomyces avermitilis MA-4680 hypothetical protein NP_821444.1 315325 D 227882 CDS NP_821445.1 29826811 1212020 complement(317520..317873) 1 NC_003155.4 hypothetical protein 317873 1212020 SAV_271 Streptomyces avermitilis MA-4680 hypothetical protein NP_821445.1 317520 R 227882 CDS NP_821446.1 29826812 1212021 319056..320099 1 NC_003155.4 hypothetical protein 320099 1212021 SAV_272 Streptomyces avermitilis MA-4680 hypothetical protein NP_821446.1 319056 D 227882 CDS NP_821447.1 29826813 1212022 320615..320959 1 NC_003155.4 DNA invertase/recombinase 320959 1212022 SAV_273 Streptomyces avermitilis MA-4680 DNA invertase/recombinase NP_821447.1 320615 D 227882 CDS NP_821448.1 29826814 1212023 complement(320979..321200) 1 NC_003155.4 IS630 family transposase 321200 1212023 SAV_274 Streptomyces avermitilis MA-4680 IS630 family transposase NP_821448.1 320979 R 227882 CDS NP_821449.1 29826815 1212024 321655..322395 1 NC_003155.4 PF06036: Streptomyces protein of unknown function (DUF921); hypothetical protein 322395 1212024 SAV_275 Streptomyces avermitilis MA-4680 hypothetical protein NP_821449.1 321655 D 227882 CDS NP_821450.1 29826816 1212025 322432..322938 1 NC_003155.4 MutT-family protein 322938 1212025 SAV_276 Streptomyces avermitilis MA-4680 MutT-family protein NP_821450.1 322432 D 227882 CDS NP_821451.1 29826817 1212026 323014..323400 1 NC_003155.4 hypothetical protein 323400 1212026 SAV_277 Streptomyces avermitilis MA-4680 hypothetical protein NP_821451.1 323014 D 227882 CDS NP_821452.1 29826818 1212027 complement(323714..324121) 1 NC_003155.4 hypothetical protein 324121 1212027 SAV_278 Streptomyces avermitilis MA-4680 hypothetical protein NP_821452.1 323714 R 227882 CDS NP_821453.1 29826819 1212028 324309..325121 1 NC_003155.4 PF02945: Recombination endonuclease VII; endonuclease 325121 1212028 SAV_279 Streptomyces avermitilis MA-4680 endonuclease NP_821453.1 324309 D 227882 CDS NP_821454.1 29826820 1212029 325362..325622 1 NC_003155.4 hypothetical protein 325622 1212029 SAV_280 Streptomyces avermitilis MA-4680 hypothetical protein NP_821454.1 325362 D 227882 CDS NP_821455.1 29826821 1212030 325633..326067 1 NC_003155.4 hypothetical protein 326067 1212030 SAV_281 Streptomyces avermitilis MA-4680 hypothetical protein NP_821455.1 325633 D 227882 CDS NP_821456.1 29826822 1212031 complement(326189..326509) 1 NC_003155.4 hypothetical protein 326509 1212031 SAV_282 Streptomyces avermitilis MA-4680 hypothetical protein NP_821456.1 326189 R 227882 CDS NP_821457.1 29826823 1212032 326629..327654 1 NC_003155.4 hypothetical protein 327654 1212032 SAV_283 Streptomyces avermitilis MA-4680 hypothetical protein NP_821457.1 326629 D 227882 CDS NP_821458.1 29826824 1212033 complement(327842..327994) 1 NC_003155.4 hypothetical protein 327994 1212033 SAV_284 Streptomyces avermitilis MA-4680 hypothetical protein NP_821458.1 327842 R 227882 CDS NP_821459.1 29826825 1212034 328293..328691 1 NC_003155.4 hypothetical protein 328691 1212034 SAV_285 Streptomyces avermitilis MA-4680 hypothetical protein NP_821459.1 328293 D 227882 CDS NP_821460.1 29826826 1212035 complement(329452..336546) 1 NC_003155.4 PF05593: RHS Repeat; large protein 336546 1212035 SAV_286 Streptomyces avermitilis MA-4680 large protein NP_821460.1 329452 R 227882 CDS NP_821461.1 29826827 1212036 complement(336652..337179) 1 NC_003155.4 IS630 family; IS630 family transposase 337179 1212036 SAV_287 Streptomyces avermitilis MA-4680 IS630 family transposase NP_821461.1 336652 R 227882 CDS NP_821462.1 29826828 1212037 complement(337203..337778) 1 NC_003155.4 IS630 family transposase 337778 1212037 SAV_288 Streptomyces avermitilis MA-4680 IS630 family transposase NP_821462.1 337203 R 227882 CDS NP_821463.1 29826829 1212038 337911..339185 1 NC_003155.4 IS4 family transposase 339185 1212038 SAV_289 Streptomyces avermitilis MA-4680 IS4 family transposase NP_821463.1 337911 D 227882 CDS NP_821464.1 29826830 1212039 complement(339271..339735) 1 NC_003155.4 IS3L-like transposase 339735 1212039 SAV_290 Streptomyces avermitilis MA-4680 IS3L-like transposase NP_821464.1 339271 R 227882 CDS NP_821465.1 29826831 1212040 complement(339819..341939) 1 NC_003155.4 IS30 family; IS30 family transposase 341939 1212040 SAV_291 Streptomyces avermitilis MA-4680 IS30 family transposase NP_821465.1 339819 R 227882 CDS NP_821466.1 29826832 1212041 343063..343689 1 NC_003155.4 TetR family transcriptional regulator 343689 1212041 SAV_292 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_821466.1 343063 D 227882 CDS NP_821467.1 29826833 1212042 complement(343805..345154) 1 NC_003155.4 PF00175: Oxidoreductase NAD-binding domain; oxidoreductase 345154 1212042 SAV_293 Streptomyces avermitilis MA-4680 oxidoreductase NP_821467.1 343805 R 227882 CDS NP_821468.1 29826834 1212043 complement(345361..345771) 1 NC_003155.4 invasion protein 345771 1212043 SAV_294 Streptomyces avermitilis MA-4680 invasion protein NP_821468.1 345361 R 227882 CDS NP_821469.1 29826835 1212044 complement(345826..346056) 1 NC_003155.4 hypothetical protein 346056 1212044 SAV_295 Streptomyces avermitilis MA-4680 hypothetical protein NP_821469.1 345826 R 227882 CDS NP_821470.1 29826836 1212045 complement(346092..347669) 1 NC_003155.4 PF01360: Monooxygenase; hypothetical protein 347669 1212045 SAV_296 Streptomyces avermitilis MA-4680 hypothetical protein NP_821470.1 346092 R 227882 CDS NP_821471.1 29826837 1212046 complement(347666..348571) 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; alpha/beta hydrolase 348571 1212046 SAV_297 Streptomyces avermitilis MA-4680 alpha/beta hydrolase NP_821471.1 347666 R 227882 CDS NP_821472.1 29826838 1212047 complement(348591..349424) 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; alpha/beta hydrolase 349424 1212047 SAV_298 Streptomyces avermitilis MA-4680 alpha/beta hydrolase NP_821472.1 348591 R 227882 CDS NP_821473.1 29826839 1212048 349710..350726 1 NC_003155.4 arylesterase/monoxygenase 350726 lipW 1212048 lipW Streptomyces avermitilis MA-4680 arylesterase/monoxygenase NP_821473.1 349710 D 227882 CDS NP_821474.1 29826840 1212049 complement(351026..352264) 1 NC_003155.4 IS256 family transposase 352264 1212049 SAV_300 Streptomyces avermitilis MA-4680 IS256 family transposase NP_821474.1 351026 R 227882 CDS NP_821475.1 29826841 1212050 352678..353949 1 NC_003155.4 PF01609: Transposase DDE domain; hypothetical protein 353949 1212050 SAV_301 Streptomyces avermitilis MA-4680 hypothetical protein NP_821475.1 352678 D 227882 CDS NP_821476.1 29826842 1212051 354545..354832 1 NC_003155.4 hypothetical protein 354832 1212051 SAV_302 Streptomyces avermitilis MA-4680 hypothetical protein NP_821476.1 354545 D 227882 CDS NP_821477.1 29826843 1212052 355009..356106 1 NC_003155.4 IS116/IS110/IS902 family; IS110 family transposase 356106 1212052 SAV_303 Streptomyces avermitilis MA-4680 IS110 family transposase NP_821477.1 355009 D 227882 CDS NP_821478.1 29826844 1212053 complement(355951..357105) 1 NC_003155.4 hypothetical protein 357105 1212053 SAV_304 Streptomyces avermitilis MA-4680 hypothetical protein NP_821478.1 355951 R 227882 CDS NP_821479.1 29826845 1212054 357868..359805 1 NC_003155.4 hypothetical protein 359805 1212054 SAV_305 Streptomyces avermitilis MA-4680 hypothetical protein NP_821479.1 357868 D 227882 CDS NP_821480.1 29826846 1212055 360375..361958 1 NC_003155.4 transcriptional regulatory protein 361958 1212055 SAV_306 Streptomyces avermitilis MA-4680 transcriptional regulatory protein NP_821480.1 360375 D 227882 CDS NP_821481.1 29826847 1212056 362562..363170 1 NC_003155.4 hypothetical protein 363170 1212056 SAV_307 Streptomyces avermitilis MA-4680 hypothetical protein NP_821481.1 362562 D 227882 CDS NP_821482.1 29826848 1212057 complement(364046..364411) 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein 364411 1212057 SAV_308 Streptomyces avermitilis MA-4680 hypothetical protein NP_821482.1 364046 R 227882 CDS NP_821483.1 29826849 1212058 366810..368000 1 NC_003155.4 PF07592: Rhodopirellula transposase; transposase 368000 1212058 SAV_309 Streptomyces avermitilis MA-4680 transposase NP_821483.1 366810 D 227882 CDS NP_821484.1 29826850 1212059 368148..368522 1 NC_003155.4 transposase 368522 1212059 SAV_310 Streptomyces avermitilis MA-4680 transposase NP_821484.1 368148 D 227882 CDS NP_821485.1 29826851 1212060 complement(368620..369621) 1 NC_003155.4 IS4 family, partial; IS4 family transposase 369621 1212060 SAV_311 Streptomyces avermitilis MA-4680 IS4 family transposase NP_821485.1 368620 R 227882 CDS NP_821486.2 57833849 1212061 complement(369344..370132) 1 NC_003155.4 IS4 family transposase 370132 1212061 SAV_312 Streptomyces avermitilis MA-4680 IS4 family transposase NP_821486.2 369344 R 227882 CDS YP_001621480.1 162960845 5815321 complement(370323..370796) 1 NC_003155.4 IS630 family IS885-like transposase 370796 5815321 SAV_7574 Streptomyces avermitilis MA-4680 IS630 family IS885-like transposase YP_001621480.1 370323 R 227882 CDS NP_821487.1 29826853 1212062 complement(371009..372637) 1 NC_003155.4 IS4 family transposase 372637 1212062 SAV_313 Streptomyces avermitilis MA-4680 IS4 family transposase NP_821487.1 371009 R 227882 CDS NP_821488.1 29826854 1212063 372788..373066 1 NC_003155.4 IS3 family transposase 373066 1212063 SAV_314 Streptomyces avermitilis MA-4680 IS3 family transposase NP_821488.1 372788 D 227882 CDS NP_821489.1 29826855 1212064 373063..373980 1 NC_003155.4 IS3 family transposase 373980 1212064 SAV_315 Streptomyces avermitilis MA-4680 IS3 family transposase NP_821489.1 373063 D 227882 CDS NP_821490.3 162960846 1212065 complement(374009..374506) 1 NC_003155.4 IS5 family, frame shift; IS630 family ISBs2-like transposase 374506 1212065 SAV_316 Streptomyces avermitilis MA-4680 IS630 family ISBs2-like transposase NP_821490.3 374009 R 227882 CDS NP_821491.1 29826857 1212066 complement(374674..375582) 1 NC_003155.4 IS5 family; hypothetical protein 375582 1212066 SAV_317 Streptomyces avermitilis MA-4680 hypothetical protein NP_821491.1 374674 R 227882 CDS NP_821492.2 57833851 1212067 complement(375668..376681) 1 NC_003155.4 IS5 family; hypothetical protein 376681 1212067 SAV_318 Streptomyces avermitilis MA-4680 hypothetical protein NP_821492.2 375668 R 227882 CDS NP_821493.2 57833852 1212068 376883..378157 1 NC_003155.4 IS4 family transposase 378157 1212068 SAV_319 Streptomyces avermitilis MA-4680 IS4 family transposase NP_821493.2 376883 D 227882 CDS NP_821494.1 29826860 1212069 complement(378281..378862) 1 NC_003155.4 hypothetical protein 378862 1212069 SAV_320 Streptomyces avermitilis MA-4680 hypothetical protein NP_821494.1 378281 R 227882 CDS NP_821495.1 29826861 1212070 complement(379220..380458) 1 NC_003155.4 PF01590: GAF domain; magnesium or manganese-dependent protein phosphatase 380458 prpB1 1212070 prpB1 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_821495.1 379220 R 227882 CDS NP_821496.1 29826862 1212071 complement(380736..381536) 1 NC_003155.4 PF03006: Haemolysin-III related; hypothetical protein 381536 1212071 SAV_322 Streptomyces avermitilis MA-4680 hypothetical protein NP_821496.1 380736 R 227882 CDS NP_821497.1 29826863 1212072 complement(381592..381924) 1 NC_003155.4 MerR family transcriptional regulator 381924 1212072 SAV_323 Streptomyces avermitilis MA-4680 MerR family transcriptional regulator NP_821497.1 381592 R 227882 CDS NP_821498.1 29826864 1212073 complement(383053..383349) 1 NC_003155.4 transcription regulator ArsR 383349 1212073 SAV_324 Streptomyces avermitilis MA-4680 transcription regulator ArsR NP_821498.1 383053 R 227882 CDS NP_821499.1 29826865 1212074 complement(383431..384198) 1 NC_003155.4 hypothetical protein 384198 1212074 SAV_325 Streptomyces avermitilis MA-4680 hypothetical protein NP_821499.1 383431 R 227882 CDS NP_821500.1 29826866 1212075 complement(385228..385533) 1 NC_003155.4 PF03819: MazG nucleotide pyrophosphohydrolase domain; hypothetical protein 385533 1212075 SAV_326 Streptomyces avermitilis MA-4680 hypothetical protein NP_821500.1 385228 R 227882 CDS NP_821501.1 29826867 1212076 complement(386051..386746) 1 NC_003155.4 hypothetical protein 386746 1212076 SAV_327 Streptomyces avermitilis MA-4680 hypothetical protein NP_821501.1 386051 R 227882 CDS NP_821502.1 29826868 1212077 386768..387076 1 NC_003155.4 hypothetical protein 387076 1212077 SAV_328 Streptomyces avermitilis MA-4680 hypothetical protein NP_821502.1 386768 D 227882 CDS NP_821503.1 29826869 1212078 387129..387536 1 NC_003155.4 hypothetical protein 387536 1212078 SAV_329 Streptomyces avermitilis MA-4680 hypothetical protein NP_821503.1 387129 D 227882 CDS NP_821504.1 29826870 1212079 complement(387639..387947) 1 NC_003155.4 hypothetical protein 387947 1212079 SAV_330 Streptomyces avermitilis MA-4680 hypothetical protein NP_821504.1 387639 R 227882 CDS NP_821505.1 29826871 1212080 complement(387951..388265) 1 NC_003155.4 hypothetical protein 388265 1212080 SAV_331 Streptomyces avermitilis MA-4680 hypothetical protein NP_821505.1 387951 R 227882 CDS NP_821506.1 29826872 1212081 complement(388386..388766) 1 NC_003155.4 hypothetical protein 388766 1212081 SAV_333 Streptomyces avermitilis MA-4680 hypothetical protein NP_821506.1 388386 R 227882 CDS NP_821507.1 29826873 1212082 388722..388958 1 NC_003155.4 hypothetical protein 388958 1212082 SAV_332 Streptomyces avermitilis MA-4680 hypothetical protein NP_821507.1 388722 D 227882 CDS NP_821508.1 29826874 1212083 389084..389704 1 NC_003155.4 hypothetical protein 389704 1212083 SAV_334 Streptomyces avermitilis MA-4680 hypothetical protein NP_821508.1 389084 D 227882 CDS NP_821509.1 29826875 1212084 complement(389694..391292) 1 NC_003155.4 hypothetical protein 391292 1212084 SAV_335 Streptomyces avermitilis MA-4680 hypothetical protein NP_821509.1 389694 R 227882 CDS NP_821510.1 29826876 1212085 complement(391476..392177) 1 NC_003155.4 hypothetical protein 392177 1212085 SAV_336 Streptomyces avermitilis MA-4680 hypothetical protein NP_821510.1 391476 R 227882 CDS NP_821511.1 29826877 1212086 392309..393166 1 NC_003155.4 hypothetical protein 393166 1212086 SAV_337 Streptomyces avermitilis MA-4680 hypothetical protein NP_821511.1 392309 D 227882 CDS NP_821512.1 29826878 1212087 complement(393683..394816) 1 NC_003155.4 hypothetical protein 394816 1212087 SAV_338 Streptomyces avermitilis MA-4680 hypothetical protein NP_821512.1 393683 R 227882 CDS NP_821513.1 29826879 1210021 complement(394813..395724) 1 NC_003155.4 PF00056: lactate/malate dehydrogenase, NAD binding domain; lactate dehydrogenase 395724 ldhA 1210021 ldhA Streptomyces avermitilis MA-4680 lactate dehydrogenase NP_821513.1 394813 R 227882 CDS NP_821514.1 29826880 1212088 complement(395736..397091) 1 NC_003155.4 hypothetical protein 397091 1212088 SAV_340 Streptomyces avermitilis MA-4680 hypothetical protein NP_821514.1 395736 R 227882 CDS NP_821515.1 29826881 1212089 complement(397379..397615) 1 NC_003155.4 hypothetical protein 397615 1212089 SAV_341 Streptomyces avermitilis MA-4680 hypothetical protein NP_821515.1 397379 R 227882 CDS NP_821516.1 29826882 1212090 complement(397612..398019) 1 NC_003155.4 hypothetical protein 398019 1212090 SAV_342 Streptomyces avermitilis MA-4680 hypothetical protein NP_821516.1 397612 R 227882 CDS NP_821517.1 29826883 1212091 398215..399555 1 NC_003155.4 PF06036: Streptomyces protein of unknown function (DUF921); regulatory protein 399555 1212091 SAV_343 Streptomyces avermitilis MA-4680 regulatory protein NP_821517.1 398215 D 227882 CDS NP_821518.1 29826884 1212092 complement(399603..400892) 1 NC_003155.4 PF06054: Competence protein CoiA-like family; hypothetical protein 400892 1212092 SAV_344 Streptomyces avermitilis MA-4680 hypothetical protein NP_821518.1 399603 R 227882 CDS NP_821519.1 29826885 1212093 401070..401894 1 NC_003155.4 hypothetical protein 401894 1212093 SAV_345 Streptomyces avermitilis MA-4680 hypothetical protein NP_821519.1 401070 D 227882 CDS NP_821520.1 29826886 1212094 402923..404059 1 NC_003155.4 hypothetical protein 404059 1212094 SAV_346 Streptomyces avermitilis MA-4680 hypothetical protein NP_821520.1 402923 D 227882 CDS NP_821521.1 29826887 1212095 complement(404592..405830) 1 NC_003155.4 IS256 family transposase 405830 1212095 SAV_347 Streptomyces avermitilis MA-4680 IS256 family transposase NP_821521.1 404592 R 227882 CDS NP_821522.1 29826888 1210022 406594..408870 1 NC_003155.4 catalase 408870 katB 1210022 katB Streptomyces avermitilis MA-4680 catalase NP_821522.1 406594 D 227882 CDS NP_821523.1 29826889 1212096 408998..409465 1 NC_003155.4 hypothetical protein 409465 1212096 SAV_349 Streptomyces avermitilis MA-4680 hypothetical protein NP_821523.1 408998 D 227882 CDS NP_821524.1 29826890 1212097 complement(409830..411953) 1 NC_003155.4 PF01590: GAF domain; magnesium or manganese-dependent protein phosphatase 411953 prpD 1212097 prpD Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_821524.1 409830 R 227882 CDS NP_821525.1 29826891 1212098 complement(412866..413366) 1 NC_003155.4 hypothetical protein 413366 1212098 SAV_351 Streptomyces avermitilis MA-4680 hypothetical protein NP_821525.1 412866 R 227882 CDS NP_821526.1 29826892 1212099 413661..414347 1 NC_003155.4 hypothetical protein 414347 1212099 SAV_352 Streptomyces avermitilis MA-4680 hypothetical protein NP_821526.1 413661 D 227882 CDS NP_821527.1 29826893 1212100 414815..416212 1 NC_003155.4 hypothetical protein 416212 1212100 SAV_353 Streptomyces avermitilis MA-4680 hypothetical protein NP_821527.1 414815 D 227882 CDS NP_821528.1 29826894 1212101 416987..419176 1 NC_003155.4 hypothetical protein 419176 1212101 SAV_354 Streptomyces avermitilis MA-4680 hypothetical protein NP_821528.1 416987 D 227882 CDS NP_821529.1 29826895 1212102 419179..420861 1 NC_003155.4 PF00534: Glycosyl transferases group 1; glycosyltransferase 420861 1212102 SAV_355 Streptomyces avermitilis MA-4680 glycosyltransferase NP_821529.1 419179 D 227882 CDS NP_821530.1 29826896 1212103 420855..422207 1 NC_003155.4 hypothetical protein 422207 1212103 SAV_356 Streptomyces avermitilis MA-4680 hypothetical protein NP_821530.1 420855 D 227882 CDS NP_821531.1 29826897 1210023 422345..423352 1 NC_003155.4 UDP-glucose 4-epimerase 423352 galE4 1210023 galE4 Streptomyces avermitilis MA-4680 UDP-glucose 4-epimerase NP_821531.1 422345 D 227882 CDS NP_821532.1 29826898 1210024 423399..424112 1 NC_003155.4 mannose-1-phosphate guanyltransferase 424112 mpg1 1210024 mpg1 Streptomyces avermitilis MA-4680 mannose-1-phosphate guanyltransferase NP_821532.1 423399 D 227882 CDS NP_821533.1 29826899 1212104 424117..425016 1 NC_003155.4 NDP-hexose 4-ketoreductase 425016 1212104 SAV_359 Streptomyces avermitilis MA-4680 NDP-hexose 4-ketoreductase NP_821533.1 424117 D 227882 CDS NP_821534.1 29826900 1212105 425013..425681 1 NC_003155.4 hypothetical protein 425681 1212105 SAV_360 Streptomyces avermitilis MA-4680 hypothetical protein NP_821534.1 425013 D 227882 CDS NP_821535.1 29826901 1212106 425823..426356 1 NC_003155.4 hypothetical protein 426356 1212106 SAV_361 Streptomyces avermitilis MA-4680 hypothetical protein NP_821535.1 425823 D 227882 CDS NP_821536.1 29826902 1212107 complement(426615..427010) 1 NC_003155.4 hypothetical protein 427010 1212107 SAV_362 Streptomyces avermitilis MA-4680 hypothetical protein NP_821536.1 426615 R 227882 CDS NP_821537.1 29826903 1212108 complement(427297..428631) 1 NC_003155.4 hypothetical protein 428631 1212108 SAV_363 Streptomyces avermitilis MA-4680 hypothetical protein NP_821537.1 427297 R 227882 CDS NP_821538.1 29826904 1212109 complement(428654..429688) 1 NC_003155.4 IS116/IS110/IS902 family; IS110 family transposase 429688 1212109 SAV_364 Streptomyces avermitilis MA-4680 IS110 family transposase NP_821538.1 428654 R 227882 CDS NP_821539.1 29826905 1212110 430053..431681 1 NC_003155.4 IS4 family transposase 431681 1212110 SAV_365 Streptomyces avermitilis MA-4680 IS4 family transposase NP_821539.1 430053 D 227882 CDS NP_821540.1 29826906 1212111 432038..434323 1 NC_003155.4 hypothetical protein 434323 1212111 SAV_366 Streptomyces avermitilis MA-4680 hypothetical protein NP_821540.1 432038 D 227882 CDS NP_821541.1 29826907 1210025 434410..437262 1 NC_003155.4 SNF2/RAD54 family helicase 437262 helZ1 1210025 helZ1 Streptomyces avermitilis MA-4680 SNF2/RAD54 family helicase NP_821541.1 434410 D 227882 CDS NP_821542.1 29826908 1212112 437259..438503 1 NC_003155.4 PF04434: SWIM zinc finger; hypothetical protein 438503 1212112 SAV_368 Streptomyces avermitilis MA-4680 hypothetical protein NP_821542.1 437259 D 227882 CDS NP_821543.1 29826909 1212113 438792..439298 1 NC_003155.4 hypothetical protein 439298 1212113 SAV_369 Streptomyces avermitilis MA-4680 hypothetical protein NP_821543.1 438792 D 227882 CDS NP_821544.1 29826910 1212114 complement(439342..439959) 1 NC_003155.4 PF00589: Phage integrase family; integrase 439959 int2 1212114 int2 Streptomyces avermitilis MA-4680 integrase NP_821544.1 439342 R 227882 CDS NP_821545.1 29826911 1212115 complement(439970..440566) 1 NC_003155.4 PF03807: NADP oxidoreductase coenzyme F420-dependent; oxidoreductase 440566 1212115 SAV_371 Streptomyces avermitilis MA-4680 oxidoreductase NP_821545.1 439970 R 227882 CDS NP_821546.1 29826912 1212116 complement(440608..441426) 1 NC_003155.4 PF00459: Inositol monophosphatase family; myo-inositol 1-monophosphatase 441426 suhB2 1212116 suhB2 Streptomyces avermitilis MA-4680 myo-inositol 1-monophosphatase NP_821546.1 440608 R 227882 CDS NP_821547.1 29826913 1212117 441565..442470 1 NC_003155.4 LysR family transcriptional regulator 442470 1212117 SAV_373 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_821547.1 441565 D 227882 CDS NP_821548.1 29826914 1212118 443421..443774 1 NC_003155.4 hypothetical protein 443774 1212118 SAV_374 Streptomyces avermitilis MA-4680 hypothetical protein NP_821548.1 443421 D 227882 CDS NP_821549.1 29826915 1212119 444076..444585 1 NC_003155.4 IS200/IS605 family; IS200-like transposase 444585 1212119 SAV_375 Streptomyces avermitilis MA-4680 IS200-like transposase NP_821549.1 444076 D 227882 CDS NP_821550.1 29826916 1212120 complement(444528..445748) 1 NC_003155.4 PF02954: Bacterial regulatory protein, Fis family; hypothetical protein 445748 1212120 SAV_376 Streptomyces avermitilis MA-4680 hypothetical protein NP_821550.1 444528 R 227882 CDS NP_821551.1 29826917 1210026 445913..447400 1 NC_003155.4 PF00501: AMP-binding enzyme; acyl-CoA synthetase, long-chain fatty acid:CoA ligase 447400 fadD1 1210026 fadD1 Streptomyces avermitilis MA-4680 acyl-CoA synthetase, long-chain fatty acid:CoA ligase NP_821551.1 445913 D 227882 CDS NP_821552.1 29826918 1212121 complement(448119..448310) 1 NC_003155.4 Tn5741 family, truncated; Tn5741 family transposase 448310 1212121 SAV_378 Streptomyces avermitilis MA-4680 Tn5741 family transposase NP_821552.1 448119 R 227882 CDS NP_821553.1 29826919 1212122 complement(449403..449558) 1 NC_003155.4 hypothetical protein 449558 1212122 SAV_379 Streptomyces avermitilis MA-4680 hypothetical protein NP_821553.1 449403 R 227882 CDS NP_821554.1 29826920 1212123 complement(449586..452924) 1 NC_003155.4 hypothetical protein 452924 1212123 SAV_380 Streptomyces avermitilis MA-4680 hypothetical protein NP_821554.1 449586 R 227882 CDS NP_821555.1 29826921 1212124 453216..454730 1 NC_003155.4 PF04984: Phage tail sheath protein; phage tail sheath protein 454730 1212124 SAV_381 Streptomyces avermitilis MA-4680 phage tail sheath protein NP_821555.1 453216 D 227882 CDS NP_821556.1 29826922 1212125 454732..455262 1 NC_003155.4 hypothetical protein 455262 1212125 SAV_382 Streptomyces avermitilis MA-4680 hypothetical protein NP_821556.1 454732 D 227882 CDS NP_821557.1 29826923 1212126 455295..456008 1 NC_003155.4 hypothetical protein 456008 1212126 SAV_383 Streptomyces avermitilis MA-4680 hypothetical protein NP_821557.1 455295 D 227882 CDS NP_821558.1 29826924 1212127 456005..456901 1 NC_003155.4 hypothetical protein 456901 1212127 SAV_384 Streptomyces avermitilis MA-4680 hypothetical protein NP_821558.1 456005 D 227882 CDS NP_821559.1 29826925 1212128 456898..458088 1 NC_003155.4 hypothetical protein 458088 1212128 SAV_385 Streptomyces avermitilis MA-4680 hypothetical protein NP_821559.1 456898 D 227882 CDS NP_821560.1 29826926 1212129 458085..459584 1 NC_003155.4 hypothetical protein 459584 1212129 SAV_386 Streptomyces avermitilis MA-4680 hypothetical protein NP_821560.1 458085 D 227882 CDS NP_821561.1 29826927 1212130 459466..460251 1 NC_003155.4 PF00004: ATPase family associated with various cellular activities (AAA); ATPase AAA 460251 1212130 SAV_387 Streptomyces avermitilis MA-4680 ATPase AAA NP_821561.1 459466 D 227882 CDS NP_821562.1 29826928 1212131 460571..461251 1 NC_003155.4 hypothetical protein 461251 1212131 SAV_388 Streptomyces avermitilis MA-4680 hypothetical protein NP_821562.1 460571 D 227882 CDS NP_821563.1 29826929 1212132 461251..461568 1 NC_003155.4 hypothetical protein 461568 1212132 SAV_389 Streptomyces avermitilis MA-4680 hypothetical protein NP_821563.1 461251 D 227882 CDS NP_821564.1 29826930 1212133 461558..462664 1 NC_003155.4 hypothetical protein 462664 1212133 SAV_390 Streptomyces avermitilis MA-4680 hypothetical protein NP_821564.1 461558 D 227882 CDS NP_821565.1 29826931 1212134 462705..463295 1 NC_003155.4 hypothetical protein 463295 1212134 SAV_391 Streptomyces avermitilis MA-4680 hypothetical protein NP_821565.1 462705 D 227882 CDS NP_821566.1 29826932 1212135 463306..463653 1 NC_003155.4 hypothetical protein 463653 1212135 SAV_392 Streptomyces avermitilis MA-4680 hypothetical protein NP_821566.1 463306 D 227882 CDS NP_821567.1 29826933 1212136 463650..464039 1 NC_003155.4 PF04965: GPW / gp25 family; hypothetical protein 464039 1212136 SAV_393 Streptomyces avermitilis MA-4680 hypothetical protein NP_821567.1 463650 D 227882 CDS NP_821568.1 29826934 1212137 464036..466855 1 NC_003155.4 hypothetical protein 466855 1212137 SAV_394 Streptomyces avermitilis MA-4680 hypothetical protein NP_821568.1 464036 D 227882 CDS NP_821569.1 29826935 1212138 466862..469465 1 NC_003155.4 hypothetical protein 469465 1212138 SAV_395 Streptomyces avermitilis MA-4680 hypothetical protein NP_821569.1 466862 D 227882 CDS NP_821570.1 29826936 1212139 469462..471561 1 NC_003155.4 hypothetical protein 471561 1212139 SAV_396 Streptomyces avermitilis MA-4680 hypothetical protein NP_821570.1 469462 D 227882 CDS NP_821571.1 29826937 1212140 471571..472863 1 NC_003155.4 hypothetical protein 472863 1212140 SAV_397 Streptomyces avermitilis MA-4680 hypothetical protein NP_821571.1 471571 D 227882 CDS NP_821572.1 29826938 1212141 472897..474789 1 NC_003155.4 hypothetical protein 474789 1212141 SAV_398 Streptomyces avermitilis MA-4680 hypothetical protein NP_821572.1 472897 D 227882 CDS NP_821573.1 29826939 1212142 complement(474824..475045) 1 NC_003155.4 hypothetical protein 475045 1212142 SAV_399 Streptomyces avermitilis MA-4680 hypothetical protein NP_821573.1 474824 R 227882 CDS NP_821574.1 29826940 1212143 complement(475108..475824) 1 NC_003155.4 PF03704: Bacterial transcriptional activator domain; transcriptional regulator 475824 1212143 SAV_400 Streptomyces avermitilis MA-4680 transcriptional regulator NP_821574.1 475108 R 227882 CDS NP_821575.1 29826941 1212144 476025..478859 1 NC_003155.4 LuxR family transcriptional regulator 478859 1212144 SAV_401 Streptomyces avermitilis MA-4680 LuxR family transcriptional regulator NP_821575.1 476025 D 227882 CDS NP_821576.1 29826942 1212145 complement(479076..479630) 1 NC_003155.4 hypothetical protein 479630 1212145 SAV_402 Streptomyces avermitilis MA-4680 hypothetical protein NP_821576.1 479076 R 227882 CDS NP_821577.1 29826943 1210027 complement(479883..481349) 1 NC_003155.4 pyridine nucleotide transhydrogenase, beta subunit 481349 pntB 1210027 pntB Streptomyces avermitilis MA-4680 pyridine nucleotide transhydrogenase, beta subunit NP_821577.1 479883 R 227882 CDS NP_821578.1 29826944 1210028 complement(481356..482912) 1 NC_003155.4 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 482912 pntA 1210028 pntA Streptomyces avermitilis MA-4680 NAD(P) transhydrogenase subunit alpha NP_821578.1 481356 R 227882 CDS NP_821579.1 29826945 1212146 484188..484907 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 484907 1212146 SAV_405 Streptomyces avermitilis MA-4680 acetyltransferase NP_821579.1 484188 D 227882 CDS NP_821580.1 29826946 1212147 484941..485378 1 NC_003155.4 PF00293: NUDIX domain; hypothetical protein 485378 1212147 SAV_406 Streptomyces avermitilis MA-4680 hypothetical protein NP_821580.1 484941 D 227882 CDS NP_821581.1 29826947 1212148 485375..485860 1 NC_003155.4 dipeptidase 485860 1212148 SAV_7575 Streptomyces avermitilis MA-4680 dipeptidase NP_821581.1 485375 D 227882 CDS NP_821582.1 29826948 1210029 complement(486648..487415) 1 NC_003155.4 filipin gene cluster; thioesterase 487415 pteH 1210029 pteH Streptomyces avermitilis MA-4680 thioesterase NP_821582.1 486648 R 227882 CDS NP_821583.1 29826949 1210030 complement(487512..489155) 1 NC_003155.4 filipin gene cluster, PF05199: GMC oxidoreductase; cholesterol oxidase 489155 pteG 1210030 pteG Streptomyces avermitilis MA-4680 cholesterol oxidase NP_821583.1 487512 R 227882 CDS NP_821584.1 29826950 1210031 complement(489621..490319) 1 NC_003155.4 filipin gene cluster; LuxR family transcriptional regulator 490319 pteF 1210031 pteF Streptomyces avermitilis MA-4680 LuxR family transcriptional regulator NP_821584.1 489621 R 227882 CDS NP_821585.1 29826951 1210032 490902..494192 1 NC_003155.4 filipin gene cluster, PF06498: Adenylate cyclase associated, PF03704: Bacterial transcriptional activator domain; DnrI/RedD/AfsR family transcriptional regulator 494192 pteR 1210032 pteR Streptomyces avermitilis MA-4680 DnrI/RedD/AfsR family transcriptional regulator NP_821585.1 490902 D 227882 CDS NP_821586.1 29826952 1210033 complement(494248..494442) 1 NC_003155.4 fdxI, filipin gene cluster; ferredoxin 494442 pteE 1210033 pteE Streptomyces avermitilis MA-4680 ferredoxin NP_821586.1 494248 R 227882 CDS NP_821587.1 29826953 1210034 complement(494487..495737) 1 NC_003155.4 CYP105D6, fdxI is located at downstream, filipin gene cluster; cytochrome P450 hydroxylase 495737 pteD 1210034 pteD Streptomyces avermitilis MA-4680 cytochrome P450 hydroxylase NP_821587.1 494487 R 227882 CDS NP_821588.1 29826954 1210035 complement(496283..497482) 1 NC_003155.4 CYP105P1, filipin gene cluster; cytochrome P450 hydroxylase 497482 pteC 1210035 pteC Streptomyces avermitilis MA-4680 cytochrome P450 hydroxylase NP_821588.1 496283 R 227882 CDS NP_821589.1 29826955 1210036 complement(497529..498785) 1 NC_003155.4 filipin gene cluster, PF00107: Zinc-binding dehydrogenase; dehydrogenase 498785 pteB 1210036 pteB Streptomyces avermitilis MA-4680 dehydrogenase NP_821589.1 497529 R 227882 CDS NP_821590.1 29826956 1210037 complement(498846..508904) 1 NC_003155.4 filipin gene cluster; modular polyketide synthase 508904 pteA5 1210037 pteA5 Streptomyces avermitilis MA-4680 modular polyketide synthase NP_821590.1 498846 R 227882 CDS NP_821591.1 29826957 1210038 complement(508951..527388) 1 NC_003155.4 filipin gene cluster; modular polyketide synthase 527388 pteA4 1210038 pteA4 Streptomyces avermitilis MA-4680 modular polyketide synthase NP_821591.1 508951 R 227882 CDS NP_821592.1 29826958 1210039 complement(527468..532975) 1 NC_003155.4 filipin gene cluster; modular polyketide synthase 532975 pteA3 1210039 pteA3 Streptomyces avermitilis MA-4680 modular polyketide synthase NP_821592.1 527468 R 227882 CDS NP_821593.1 29826959 1210040 complement(533011..543705) 1 NC_003155.4 filipin gene cluster; modular polyketide synthase 543705 pteA2 1210040 pteA2 Streptomyces avermitilis MA-4680 modular polyketide synthase NP_821593.1 533011 R 227882 CDS NP_821594.1 29826960 1210041 complement(543777..567017) 1 NC_003155.4 filipin gene cluster; modular polyketide synthase 567017 pteA1 1210041 pteA1 Streptomyces avermitilis MA-4680 modular polyketide synthase NP_821594.1 543777 R 227882 CDS NP_821595.1 29826961 1212149 567663..568697 1 NC_003155.4 PF01526: Transposase; transposase 568697 1212149 SAV_420 Streptomyces avermitilis MA-4680 transposase NP_821595.1 567663 D 227882 CDS NP_821596.1 29826962 1212150 568699..569952 1 NC_003155.4 PF03734: ErfK/YbiS/YcfS/YnhG; lipoprotein 569952 1212150 SAV_421 Streptomyces avermitilis MA-4680 lipoprotein NP_821596.1 568699 D 227882 CDS NP_821597.1 29826963 1212151 complement(570215..570763) 1 NC_003155.4 hypothetical protein 570763 1212151 SAV_422 Streptomyces avermitilis MA-4680 hypothetical protein NP_821597.1 570215 R 227882 CDS NP_821598.1 29826964 1212152 570940..571578 1 NC_003155.4 IS30 family, partial; IS30 family transposase 571578 1212152 SAV_423 Streptomyces avermitilis MA-4680 IS30 family transposase NP_821598.1 570940 D 227882 CDS YP_187527.1 57833853 3238945 571598..571915 1 NC_003155.4 IS3 family, partial; IS3 family transposase 571915 3238945 SAV_7576 Streptomyces avermitilis MA-4680 IS3 family transposase YP_187527.1 571598 D 227882 CDS NP_821599.1 29826965 1210042 complement(573907..574845) 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 574845 sig3 1210042 sig3 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_821599.1 573907 R 227882 CDS NP_821600.1 29826966 1212153 complement(574856..576046) 1 NC_003155.4 PF00070: Pyridine nucleotide-disulphide oxidoreductase; oxidoreductase 576046 1212153 SAV_425 Streptomyces avermitilis MA-4680 oxidoreductase NP_821600.1 574856 R 227882 CDS NP_821601.1 29826967 1212154 complement(576232..576603) 1 NC_003155.4 hypothetical protein 576603 1212154 SAV_426 Streptomyces avermitilis MA-4680 hypothetical protein NP_821601.1 576232 R 227882 CDS NP_821602.1 29826968 1212155 complement(576830..577165) 1 NC_003155.4 hypothetical protein 577165 1212155 SAV_427 Streptomyces avermitilis MA-4680 hypothetical protein NP_821602.1 576830 R 227882 CDS NP_821603.1 29826969 1212156 complement(577719..578180) 1 NC_003155.4 PF03364: Streptomyces cyclase/dehydrase; hypothetical protein 578180 1212156 SAV_428 Streptomyces avermitilis MA-4680 hypothetical protein NP_821603.1 577719 R 227882 CDS NP_821604.1 29826970 1212157 579136..579753 1 NC_003155.4 PF02627: Carboxymuconolactone decarboxylase family; hypothetical protein 579753 1212157 SAV_429 Streptomyces avermitilis MA-4680 hypothetical protein NP_821604.1 579136 D 227882 CDS NP_821605.1 29826971 1212158 579746..580549 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 580549 1212158 SAV_430 Streptomyces avermitilis MA-4680 dehydrogenase NP_821605.1 579746 D 227882 CDS NP_821606.1 29826972 1212159 complement(580610..581254) 1 NC_003155.4 TetR family transcriptional regulator 581254 1212159 SAV_431 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_821606.1 580610 R 227882 CDS NP_821607.1 29826973 1212160 581626..582858 1 NC_003155.4 PF02415: Chlamydia polymorphic membrane protein (Chlamydia_PMP); hypothetical protein 582858 1212160 SAV_432 Streptomyces avermitilis MA-4680 hypothetical protein NP_821607.1 581626 D 227882 CDS NP_821608.1 29826974 1212161 582893..584755 1 NC_003155.4 PF00135: Carboxylesterase; carboxylesterase 584755 1212161 SAV_433 Streptomyces avermitilis MA-4680 carboxylesterase NP_821608.1 582893 D 227882 CDS NP_821609.1 29826975 1212162 584755..585144 1 NC_003155.4 hypothetical protein 585144 1212162 SAV_434 Streptomyces avermitilis MA-4680 hypothetical protein NP_821609.1 584755 D 227882 CDS NP_821610.1 29826976 1212163 585449..585874 1 NC_003155.4 hypothetical protein 585874 1212163 SAV_435 Streptomyces avermitilis MA-4680 hypothetical protein NP_821610.1 585449 D 227882 CDS NP_821611.1 29826977 1212164 complement(585858..586517) 1 NC_003155.4 TetR family transcriptional regulator 586517 1212164 SAV_436 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_821611.1 585858 R 227882 CDS NP_821612.1 29826978 1212165 complement(587625..590051) 1 NC_003155.4 PF01590: GAF domain; magnesium or manganese-dependent protein phosphatase 590051 prpM1 1212165 prpM1 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_821612.1 587625 R 227882 CDS NP_821613.1 29826979 1212166 complement(590678..591778) 1 NC_003155.4 hypothetical protein 591778 1212166 SAV_438 Streptomyces avermitilis MA-4680 hypothetical protein NP_821613.1 590678 R 227882 CDS NP_821614.1 29826980 1212167 complement(592072..592773) 1 NC_003155.4 hypothetical protein 592773 1212167 SAV_439 Streptomyces avermitilis MA-4680 hypothetical protein NP_821614.1 592072 R 227882 CDS NP_821615.1 29826981 1210043 594232..595248 1 NC_003155.4 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 595248 rpoA2 1210043 rpoA2 Streptomyces avermitilis MA-4680 DNA-directed RNA polymerase subunit alpha NP_821615.1 594232 D 227882 CDS NP_821616.1 29826982 1212168 595471..596031 1 NC_003155.4 IS3L-like transposase 596031 1212168 SAV_441 Streptomyces avermitilis MA-4680 IS3L-like transposase NP_821616.1 595471 D 227882 CDS NP_821617.1 29826983 1212169 596538..596843 1 NC_003155.4 hypothetical protein 596843 1212169 SAV_442 Streptomyces avermitilis MA-4680 hypothetical protein NP_821617.1 596538 D 227882 CDS NP_821618.1 29826984 1212170 596972..597148 1 NC_003155.4 hypothetical protein 597148 1212170 SAV_443 Streptomyces avermitilis MA-4680 hypothetical protein NP_821618.1 596972 D 227882 CDS NP_821619.1 29826985 1212171 complement(598312..600774) 1 NC_003155.4 PF05593: RHS Repeat; cell wall-associated protein 600774 wapA 1212171 wapA Streptomyces avermitilis MA-4680 cell wall-associated protein NP_821619.1 598312 R 227882 CDS NP_821620.1 29826986 1212172 complement(601030..601425) 1 NC_003155.4 Tn4561 family, truncated; Tn4561 family transposase 601425 1212172 SAV_445 Streptomyces avermitilis MA-4680 Tn4561 family transposase NP_821620.1 601030 R 227882 CDS NP_821621.1 29826987 1212173 complement(601349..601615) 1 NC_003155.4 IS630 family, truncated; IS630 family transposase 601615 1212173 SAV_446 Streptomyces avermitilis MA-4680 IS630 family transposase NP_821621.1 601349 R 227882 CDS NP_821622.1 29826988 1212174 601641..601862 1 NC_003155.4 IS630 family, truncated; IS630 family transposase 601862 1212174 SAV_447 Streptomyces avermitilis MA-4680 IS630 family transposase NP_821622.1 601641 D 227882 CDS NP_821623.1 29826989 1212175 complement(602829..603446) 1 NC_003155.4 TetR family transcriptional regulator 603446 1212175 SAV_448 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_821623.1 602829 R 227882 CDS NP_821624.1 29826990 1212176 603569..603973 1 NC_003155.4 hypothetical protein 603973 1212176 SAV_449 Streptomyces avermitilis MA-4680 hypothetical protein NP_821624.1 603569 D 227882 CDS NP_821625.1 29826991 1212177 604002..604904 1 NC_003155.4 hypothetical protein 604904 1212177 SAV_450 Streptomyces avermitilis MA-4680 hypothetical protein NP_821625.1 604002 D 227882 CDS NP_821626.1 29826992 1210044 complement(605005..605373) 1 NC_003155.4 PF01740: STAS domain; anti-sigma factor antagonist 605373 bldG 1210044 bldG Streptomyces avermitilis MA-4680 anti-sigma factor antagonist NP_821626.1 605005 R 227882 CDS NP_821627.1 29826993 1212178 605510..606031 1 NC_003155.4 hypothetical protein 606031 1212178 SAV_452 Streptomyces avermitilis MA-4680 hypothetical protein NP_821627.1 605510 D 227882 CDS NP_821628.1 29826994 1212179 606058..606540 1 NC_003155.4 hypothetical protein 606540 1212179 SAV_453 Streptomyces avermitilis MA-4680 hypothetical protein NP_821628.1 606058 D 227882 CDS NP_821629.1 29826995 1212180 606685..607839 1 NC_003155.4 hypothetical protein 607839 1212180 SAV_454 Streptomyces avermitilis MA-4680 hypothetical protein NP_821629.1 606685 D 227882 CDS NP_821630.1 29826996 1212181 complement(607861..608373) 1 NC_003155.4 hypothetical protein 608373 1212181 SAV_455 Streptomyces avermitilis MA-4680 hypothetical protein NP_821630.1 607861 R 227882 CDS NP_821631.1 29826997 1212182 608423..609064 1 NC_003155.4 hypothetical protein 609064 1212182 SAV_456 Streptomyces avermitilis MA-4680 hypothetical protein NP_821631.1 608423 D 227882 CDS NP_821632.1 29826998 1212183 complement(609036..610703) 1 NC_003155.4 PF04434: SWIM zinc finger; hypothetical protein 610703 1212183 SAV_457 Streptomyces avermitilis MA-4680 hypothetical protein NP_821632.1 609036 R 227882 CDS NP_821633.1 29826999 1212184 complement(611754..612434) 1 NC_003155.4 hsp18 transcriptional regulator 612434 1212184 SAV_458 Streptomyces avermitilis MA-4680 hsp18 transcriptional regulator NP_821633.1 611754 R 227882 CDS NP_821634.1 29827000 1210045 612565..612999 1 NC_003155.4 PF00011: Hsp20/alpha crystallin family; heat shock protein 612999 hspX 1210045 hspX Streptomyces avermitilis MA-4680 heat shock protein NP_821634.1 612565 D 227882 CDS NP_821635.1 29827001 1212185 613088..613483 1 NC_003155.4 hypothetical protein 613483 1212185 SAV_460 Streptomyces avermitilis MA-4680 hypothetical protein NP_821635.1 613088 D 227882 CDS NP_821636.1 29827002 1212186 complement(613563..614081) 1 NC_003155.4 hypothetical protein 614081 1212186 SAV_461 Streptomyces avermitilis MA-4680 hypothetical protein NP_821636.1 613563 R 227882 CDS NP_821637.1 29827003 1212187 complement(614386..614700) 1 NC_003155.4 hypothetical protein 614700 1212187 SAV_462 Streptomyces avermitilis MA-4680 hypothetical protein NP_821637.1 614386 R 227882 CDS NP_821638.1 29827004 1212188 complement(614793..614951) 1 NC_003155.4 hypothetical protein 614951 1212188 SAV_463 Streptomyces avermitilis MA-4680 hypothetical protein NP_821638.1 614793 R 227882 CDS NP_821639.1 29827005 1212189 complement(615205..615528) 1 NC_003155.4 hypothetical protein 615528 1212189 SAV_464 Streptomyces avermitilis MA-4680 hypothetical protein NP_821639.1 615205 R 227882 CDS NP_821640.1 29827006 1212190 615875..616378 1 NC_003155.4 PF00190: Cupin doamin, 100% same as SAV878; hypothetical protein 616378 1212190 SAV_465 Streptomyces avermitilis MA-4680 hypothetical protein NP_821640.1 615875 D 227882 CDS NP_821641.1 29827007 1212191 618189..618728 1 NC_003155.4 hypothetical protein 618728 1212191 SAV_466 Streptomyces avermitilis MA-4680 hypothetical protein NP_821641.1 618189 D 227882 CDS NP_821642.1 29827008 1212192 618731..619111 1 NC_003155.4 hypothetical protein 619111 1212192 SAV_467 Streptomyces avermitilis MA-4680 hypothetical protein NP_821642.1 618731 D 227882 CDS NP_821643.1 29827009 1212193 619319..619990 1 NC_003155.4 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily; oxygenase 619990 1212193 SAV_468 Streptomyces avermitilis MA-4680 oxygenase NP_821643.1 619319 D 227882 CDS NP_821644.1 29827010 1212194 620530..621735 1 NC_003155.4 PF03403: Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II; lipase 621735 1212194 SAV_469 Streptomyces avermitilis MA-4680 lipase NP_821644.1 620530 D 227882 CDS NP_821645.1 29827011 1212195 621832..622614 1 NC_003155.4 PF01609: Transposase DDE domain; transposase 622614 1212195 SAV_470 Streptomyces avermitilis MA-4680 transposase NP_821645.1 621832 D 227882 CDS NP_821646.1 29827012 1212196 622993..623559 1 NC_003155.4 PF01872: RibD C-terminal domain; hypothetical protein 623559 1212196 SAV_471 Streptomyces avermitilis MA-4680 hypothetical protein NP_821646.1 622993 D 227882 CDS NP_821647.1 29827013 1212197 complement(624344..625432) 1 NC_003155.4 PF00165: Bacterial regulatory helix-turn-helix proteins, araC family; regulatory protein 625432 1212197 SAV_472 Streptomyces avermitilis MA-4680 regulatory protein NP_821647.1 624344 R 227882 CDS NP_821648.1 29827014 1212198 complement(625518..626249) 1 NC_003155.4 transposase 626249 1212198 SAV_473 Streptomyces avermitilis MA-4680 transposase NP_821648.1 625518 R 227882 CDS NP_821649.1 29827015 1212199 complement(626420..627271) 1 NC_003155.4 methyltransferase 627271 1212199 SAV_474 Streptomyces avermitilis MA-4680 methyltransferase NP_821649.1 626420 R 227882 CDS NP_821650.1 29827016 1212200 complement(627377..627523) 1 NC_003155.4 hypothetical protein 627523 1212200 SAV_475 Streptomyces avermitilis MA-4680 hypothetical protein NP_821650.1 627377 R 227882 CDS NP_821651.1 29827017 1212201 complement(627541..628107) 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein 628107 1212201 SAV_476 Streptomyces avermitilis MA-4680 hypothetical protein NP_821651.1 627541 R 227882 CDS NP_821652.1 29827018 1212202 628625..628882 1 NC_003155.4 hypothetical protein 628882 1212202 SAV_477 Streptomyces avermitilis MA-4680 hypothetical protein NP_821652.1 628625 D 227882 CDS NP_821653.1 29827019 1212203 629473..629790 1 NC_003155.4 hypothetical protein 629790 1212203 SAV_478 Streptomyces avermitilis MA-4680 hypothetical protein NP_821653.1 629473 D 227882 CDS NP_821654.1 29827020 1212204 complement(629806..630354) 1 NC_003155.4 IS630 family (630954..629809) Translation will be controlled by framenshift with SAV480.; IS630 family transposase 630354 1212204 SAV_479 Streptomyces avermitilis MA-4680 IS630 family transposase NP_821654.1 629806 R 227882 CDS NP_821655.1 29827021 1212205 complement(630351..630686) 1 NC_003155.4 IS630 family (630954..629809) Target sequence (TA).; IS630 family transposase 630686 1212205 SAV_480 Streptomyces avermitilis MA-4680 IS630 family transposase NP_821655.1 630351 R 227882 CDS NP_821656.1 29827022 1212206 complement(630951..631274) 1 NC_003155.4 hypothetical protein 631274 1212206 SAV_482 Streptomyces avermitilis MA-4680 hypothetical protein NP_821656.1 630951 R 227882 CDS NP_821657.1 29827023 1212207 631222..631539 1 NC_003155.4 hypothetical protein 631539 1212207 SAV_481 Streptomyces avermitilis MA-4680 hypothetical protein NP_821657.1 631222 D 227882 CDS NP_821658.1 29827024 1212208 complement(631562..631783) 1 NC_003155.4 hypothetical protein 631783 1212208 SAV_483 Streptomyces avermitilis MA-4680 hypothetical protein NP_821658.1 631562 R 227882 CDS NP_821659.1 29827025 1212209 complement(631817..632638) 1 NC_003155.4 ubiE/COQ5 methyltransferase family protein 632638 1212209 SAV_484 Streptomyces avermitilis MA-4680 ubiE/COQ5 methyltransferase family protein NP_821659.1 631817 R 227882 CDS NP_821660.1 29827026 1212210 632948..633259 1 NC_003155.4 hypothetical protein 633259 1212210 SAV_485 Streptomyces avermitilis MA-4680 hypothetical protein NP_821660.1 632948 D 227882 CDS NP_821661.1 29827027 1212211 633243..633470 1 NC_003155.4 hypothetical protein 633470 1212211 SAV_486 Streptomyces avermitilis MA-4680 hypothetical protein NP_821661.1 633243 D 227882 CDS NP_821662.1 29827028 1212212 complement(633937..634218) 1 NC_003155.4 hypothetical protein 634218 1212212 SAV_487 Streptomyces avermitilis MA-4680 hypothetical protein NP_821662.1 633937 R 227882 CDS NP_821663.1 29827029 1212213 complement(634378..635061) 1 NC_003155.4 TetR family transcriptional regulator 635061 1212213 SAV_488 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_821663.1 634378 R 227882 CDS NP_821664.1 29827030 1212214 635181..635900 1 NC_003155.4 hypothetical protein 635900 1212214 SAV_489 Streptomyces avermitilis MA-4680 hypothetical protein NP_821664.1 635181 D 227882 CDS NP_821665.1 29827031 1212215 complement(636261..636563) 1 NC_003155.4 hypothetical protein 636563 1212215 SAV_490 Streptomyces avermitilis MA-4680 hypothetical protein NP_821665.1 636261 R 227882 CDS NP_821666.1 29827032 1212216 complement(636931..637317) 1 NC_003155.4 PF01638: Transcriptional regulator; transcriptional regulator 637317 1212216 SAV_491 Streptomyces avermitilis MA-4680 transcriptional regulator NP_821666.1 636931 R 227882 CDS NP_821667.1 29827033 1210046 637423..638256 1 NC_003155.4 enoyl-CoA hydratase 638256 echA1 1210046 echA1 Streptomyces avermitilis MA-4680 enoyl-CoA hydratase NP_821667.1 637423 D 227882 CDS NP_821668.1 29827034 1212217 complement(639053..639388) 1 NC_003155.4 hypothetical protein 639388 1212217 SAV_493 Streptomyces avermitilis MA-4680 hypothetical protein NP_821668.1 639053 R 227882 CDS NP_821669.1 29827035 1212218 complement(640006..640821) 1 NC_003155.4 hypothetical protein 640821 1212218 SAV_494 Streptomyces avermitilis MA-4680 hypothetical protein NP_821669.1 640006 R 227882 CDS NP_821670.1 29827036 1212219 641145..641333 1 NC_003155.4 hypothetical protein 641333 1212219 SAV_495 Streptomyces avermitilis MA-4680 hypothetical protein NP_821670.1 641145 D 227882 CDS NP_821671.1 29827037 1212220 641343..641822 1 NC_003155.4 hypothetical protein 641822 1212220 SAV_496 Streptomyces avermitilis MA-4680 hypothetical protein NP_821671.1 641343 D 227882 CDS NP_821672.1 29827038 1212221 642389..642613 1 NC_003155.4 probably pseudogene; integrase/recombinase 642613 int3 1212221 int3 Streptomyces avermitilis MA-4680 integrase/recombinase NP_821672.1 642389 D 227882 CDS NP_821673.1 29827039 1212222 642610..643092 1 NC_003155.4 integrase/recombinase 643092 int4 1212222 int4 Streptomyces avermitilis MA-4680 integrase/recombinase NP_821673.1 642610 D 227882 CDS NP_821674.1 29827040 1212223 complement(643080..643727) 1 NC_003155.4 PF00320: GATA zinc finger; hypothetical protein 643727 1212223 SAV_499 Streptomyces avermitilis MA-4680 hypothetical protein NP_821674.1 643080 R 227882 CDS NP_821675.1 29827041 1212224 643739..644002 1 NC_003155.4 hypothetical protein 644002 1212224 SAV_500 Streptomyces avermitilis MA-4680 hypothetical protein NP_821675.1 643739 D 227882 CDS NP_821676.1 29827042 1212225 complement(644154..645011) 1 NC_003155.4 nuclease 645011 1212225 SAV_501 Streptomyces avermitilis MA-4680 nuclease NP_821676.1 644154 R 227882 CDS NP_821677.1 29827043 1212226 complement(645222..645671) 1 NC_003155.4 hypothetical protein 645671 1212226 SAV_502 Streptomyces avermitilis MA-4680 hypothetical protein NP_821677.1 645222 R 227882 CDS NP_821678.1 29827044 1212227 complement(646464..646712) 1 NC_003155.4 hypothetical protein 646712 1212227 SAV_503 Streptomyces avermitilis MA-4680 hypothetical protein NP_821678.1 646464 R 227882 CDS NP_821679.1 29827045 1210047 complement(646906..647130) 1 NC_003155.4 translation initiation factor IF-1 647130 infA2 1210047 infA2 Streptomyces avermitilis MA-4680 translation initiation factor IF-1 NP_821679.1 646906 R 227882 CDS YP_187528.1 57833854 3238948 complement(648107..648520) 1 NC_003155.4 IS5 family; hypothetical protein 648520 3238948 SAV_7577 Streptomyces avermitilis MA-4680 hypothetical protein YP_187528.1 648107 R 227882 CDS NP_821680.1 29827046 1212228 complement(648664..649314) 1 NC_003155.4 PF03992: Antibiotic biosynthesis monooxygenase; monooxygenase 649314 1212228 SAV_505 Streptomyces avermitilis MA-4680 monooxygenase NP_821680.1 648664 R 227882 CDS NP_821681.1 29827047 1212229 650027..650887 1 NC_003155.4 PF07690: Major Facilitator Superfamily; hypothetical protein 650887 1212229 SAV_506 Streptomyces avermitilis MA-4680 hypothetical protein NP_821681.1 650027 D 227882 CDS NP_821682.1 29827048 1212230 complement(652300..653355) 1 NC_003155.4 cinnamoyl-CoA reductase 653355 1212230 SAV_507 Streptomyces avermitilis MA-4680 cinnamoyl-CoA reductase NP_821682.1 652300 R 227882 CDS NP_821683.1 29827049 1212231 653742..654326 1 NC_003155.4 TetR family transcriptional regulator 654326 1212231 SAV_508 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_821683.1 653742 D 227882 CDS NP_821684.1 29827050 1212232 complement(654353..654727) 1 NC_003155.4 transposase 654727 1212232 SAV_509 Streptomyces avermitilis MA-4680 transposase NP_821684.1 654353 R 227882 CDS NP_821685.1 29827051 1212233 654951..655112 1 NC_003155.4 hypothetical protein 655112 1212233 SAV_510 Streptomyces avermitilis MA-4680 hypothetical protein NP_821685.1 654951 D 227882 CDS NP_821686.1 29827052 1212234 complement(655559..656608) 1 NC_003155.4 PF01966: HD domain; hypothetical protein 656608 1212234 SAV_511 Streptomyces avermitilis MA-4680 hypothetical protein NP_821686.1 655559 R 227882 CDS NP_821687.1 29827053 1212235 complement(656762..657562) 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 657562 1212235 SAV_512 Streptomyces avermitilis MA-4680 hydrolase NP_821687.1 656762 R 227882 CDS NP_821688.1 29827054 1212236 657798..658799 1 NC_003155.4 PF01965: DJ-1/PfpI family; AraC family transcription regulator 658799 1212236 SAV_513 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_821688.1 657798 D 227882 CDS NP_821689.1 29827055 1212237 658738..659214 1 NC_003155.4 hypothetical protein 659214 1212237 SAV_514 Streptomyces avermitilis MA-4680 hypothetical protein NP_821689.1 658738 D 227882 CDS NP_821690.1 29827056 1212238 complement(659554..660030) 1 NC_003155.4 PF01799: [2Fe-2S] binding domain; oxidoreductase with iron-sulfur subunit 660030 1212238 SAV_515 Streptomyces avermitilis MA-4680 oxidoreductase with iron-sulfur subunit NP_821690.1 659554 R 227882 CDS NP_821691.1 29827057 1212239 complement(660050..662125) 1 NC_003155.4 PF02738: Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding domain; oxidoreductase 662125 1212239 SAV_516 Streptomyces avermitilis MA-4680 oxidoreductase NP_821691.1 660050 R 227882 CDS NP_821692.1 29827058 1212240 complement(662516..663070) 1 NC_003155.4 PF01527: Transposase; hypothetical protein 663070 1212240 SAV_517 Streptomyces avermitilis MA-4680 hypothetical protein NP_821692.1 662516 R 227882 CDS NP_821693.1 29827059 1212241 complement(663079..663246) 1 NC_003155.4 hypothetical protein 663246 1212241 SAV_518 Streptomyces avermitilis MA-4680 hypothetical protein NP_821693.1 663079 R 227882 CDS NP_821694.1 29827060 1212242 complement(663296..664171) 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 664171 1212242 SAV_519 Streptomyces avermitilis MA-4680 hydrolase NP_821694.1 663296 R 227882 CDS NP_821695.1 29827061 1212243 complement(664226..664873) 1 NC_003155.4 PF01638: Transcriptional regulator; transcriptional regulator 664873 1212243 SAV_520 Streptomyces avermitilis MA-4680 transcriptional regulator NP_821695.1 664226 R 227882 CDS NP_821696.1 29827062 1212244 665000..665731 1 NC_003155.4 hypothetical protein 665731 1212244 SAV_521 Streptomyces avermitilis MA-4680 hypothetical protein NP_821696.1 665000 D 227882 CDS NP_821697.1 29827063 1212245 665728..665937 1 NC_003155.4 hypothetical protein 665937 1212245 SAV_522 Streptomyces avermitilis MA-4680 hypothetical protein NP_821697.1 665728 D 227882 CDS NP_821698.1 29827064 1212246 complement(666194..667279) 1 NC_003155.4 transposase 667279 1212246 SAV_523 Streptomyces avermitilis MA-4680 transposase NP_821698.1 666194 R 227882 CDS NP_821699.1 29827065 1212247 668142..668879 1 NC_003155.4 CDP-diacylglycerol phosphotidylhydrolase 668879 cdh 1212247 cdh Streptomyces avermitilis MA-4680 CDP-diacylglycerol phosphotidylhydrolase NP_821699.1 668142 D 227882 CDS NP_821700.1 29827066 1212248 669258..669710 1 NC_003155.4 transposase 669710 1212248 SAV_525 Streptomyces avermitilis MA-4680 transposase NP_821700.1 669258 D 227882 CDS NP_821701.1 29827067 1212249 complement(670688..671113) 1 NC_003155.4 hypothetical protein 671113 1212249 SAV_526 Streptomyces avermitilis MA-4680 hypothetical protein NP_821701.1 670688 R 227882 CDS NP_821702.1 29827068 1210048 671956..672573 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 672573 sig4 1210048 sig4 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_821702.1 671956 D 227882 CDS NP_821703.1 29827069 1212250 672570..673388 1 NC_003155.4 integral membrane protein 673388 1212250 SAV_528 Streptomyces avermitilis MA-4680 integral membrane protein NP_821703.1 672570 D 227882 CDS NP_821704.1 29827070 1212251 673385..674218 1 NC_003155.4 ABC transporter ATP-binding protein 674218 1212251 SAV_529 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_821704.1 673385 D 227882 CDS NP_821705.1 29827071 1212252 674215..675609 1 NC_003155.4 hypothetical protein 675609 1212252 SAV_530 Streptomyces avermitilis MA-4680 hypothetical protein NP_821705.1 674215 D 227882 CDS NP_821706.1 29827072 1212253 675606..676181 1 NC_003155.4 hypothetical protein 676181 1212253 SAV_531 Streptomyces avermitilis MA-4680 hypothetical protein NP_821706.1 675606 D 227882 CDS NP_821707.1 29827073 1212254 676319..676693 1 NC_003155.4 hypothetical protein 676693 1212254 SAV_532 Streptomyces avermitilis MA-4680 hypothetical protein NP_821707.1 676319 D 227882 CDS NP_821708.1 29827074 1212255 676902..677138 1 NC_003155.4 hypothetical protein 677138 1212255 SAV_533 Streptomyces avermitilis MA-4680 hypothetical protein NP_821708.1 676902 D 227882 CDS NP_821709.1 29827075 1212256 677241..678026 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 678026 1212256 SAV_534 Streptomyces avermitilis MA-4680 acetyltransferase NP_821709.1 677241 D 227882 CDS NP_821710.1 29827076 1212257 678091..678423 1 NC_003155.4 hypothetical protein 678423 1212257 SAV_535 Streptomyces avermitilis MA-4680 hypothetical protein NP_821710.1 678091 D 227882 CDS NP_821711.1 29827077 1212258 complement(678456..678746) 1 NC_003155.4 hypothetical protein 678746 1212258 SAV_536 Streptomyces avermitilis MA-4680 hypothetical protein NP_821711.1 678456 R 227882 CDS NP_821712.1 29827078 1212259 679055..679966 1 NC_003155.4 Sir2-family regulator protein 679966 1212259 SAV_537 Streptomyces avermitilis MA-4680 Sir2-family regulator protein NP_821712.1 679055 D 227882 CDS NP_821713.1 29827079 1212260 680351..680782 1 NC_003155.4 hypothetical protein 680782 1212260 SAV_538 Streptomyces avermitilis MA-4680 hypothetical protein NP_821713.1 680351 D 227882 CDS NP_821714.1 29827080 1212261 complement(681371..682687) 1 NC_003155.4 hypothetical protein 682687 1212261 SAV_539 Streptomyces avermitilis MA-4680 hypothetical protein NP_821714.1 681371 R 227882 CDS NP_821715.1 29827081 1212262 complement(683712..684113) 1 NC_003155.4 MerR family transcriptional regulator 684113 1212262 SAV_540 Streptomyces avermitilis MA-4680 MerR family transcriptional regulator NP_821715.1 683712 R 227882 CDS NP_821716.1 29827082 1212263 684229..684993 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase 684993 1212263 SAV_541 Streptomyces avermitilis MA-4680 3-oxoadipate enol-lactone hydrolase/4-carboxymuconolactone decarboxylase NP_821716.1 684229 D 227882 CDS NP_821717.1 29827083 1212264 685826..686794 1 NC_003155.4 hypothetical protein 686794 1212264 SAV_542 Streptomyces avermitilis MA-4680 hypothetical protein NP_821717.1 685826 D 227882 CDS NP_821718.1 29827084 1210049 complement(687276..688139) 1 NC_003155.4 PF02882: Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain; methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase 688139 folD2 1210049 folD2 Streptomyces avermitilis MA-4680 methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase NP_821718.1 687276 R 227882 CDS NP_821719.1 29827085 1212265 complement(688569..689843) 1 NC_003155.4 PF00082: Subtilase family; serine protease 689843 1212265 SAV_544 Streptomyces avermitilis MA-4680 serine protease NP_821719.1 688569 R 227882 CDS NP_821720.1 29827086 1210050 complement(690137..690814) 1 NC_003155.4 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 690814 ribA 1210050 ribA Streptomyces avermitilis MA-4680 GTP cyclohydrolase II NP_821720.1 690137 R 227882 CDS NP_821721.1 29827087 1212266 complement(690909..691955) 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 691955 1212266 SAV_546 Streptomyces avermitilis MA-4680 dehydrogenase NP_821721.1 690909 R 227882 CDS NP_821722.1 29827088 1212267 complement(692180..693268) 1 NC_003155.4 PF00515: TPR Domain; hypothetical protein 693268 1212267 SAV_547 Streptomyces avermitilis MA-4680 hypothetical protein NP_821722.1 692180 R 227882 CDS NP_821723.1 29827089 1212268 complement(693265..694434) 1 NC_003155.4 hypothetical protein 694434 1212268 SAV_548 Streptomyces avermitilis MA-4680 hypothetical protein NP_821723.1 693265 R 227882 CDS NP_821724.1 29827090 1212269 complement(694471..695799) 1 NC_003155.4 peroxidase 695799 1212269 SAV_549 Streptomyces avermitilis MA-4680 peroxidase NP_821724.1 694471 R 227882 CDS NP_821725.1 29827091 1212270 complement(695916..696545) 1 NC_003155.4 hypothetical protein 696545 1212270 SAV_550 Streptomyces avermitilis MA-4680 hypothetical protein NP_821725.1 695916 R 227882 CDS NP_821726.1 29827092 1212271 complement(696920..697507) 1 NC_003155.4 TetR family transcriptional regulator 697507 1212271 SAV_551 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_821726.1 696920 R 227882 CDS NP_821727.1 29827093 1212272 complement(697702..699213) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 699213 1212272 SAV_552 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_821727.1 697702 R 227882 CDS NP_821728.1 29827094 1212273 complement(700072..700701) 1 NC_003155.4 hypothetical protein 700701 1212273 SAV_553 Streptomyces avermitilis MA-4680 hypothetical protein NP_821728.1 700072 R 227882 CDS NP_821729.1 29827095 1212274 701238..702260 1 NC_003155.4 LacI family transcriptional regulator 702260 1212274 SAV_554 Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_821729.1 701238 D 227882 CDS NP_821730.1 29827096 1210051 702503..703630 1 NC_003155.4 endo-1,4-beta-glucanase 703630 celA1 1210051 celA1 Streptomyces avermitilis MA-4680 endo-1,4-beta-glucanase NP_821730.1 702503 D 227882 CDS NP_821731.1 29827097 1210052 703943..704353 1 NC_003155.4 cellulose binding protein 704353 celS1 1210052 celS1 Streptomyces avermitilis MA-4680 cellulose binding protein NP_821731.1 703943 D 227882 CDS NP_821732.1 29827098 1210053 704446..706671 1 NC_003155.4 cellulose 1,4-beta-cellobiosidase 706671 guxA1 1210053 guxA1 Streptomyces avermitilis MA-4680 cellulose 1,4-beta-cellobiosidase NP_821732.1 704446 D 227882 CDS NP_821733.1 29827099 1212275 707738..708082 1 NC_003155.4 hypothetical protein 708082 1212275 SAV_558 Streptomyces avermitilis MA-4680 hypothetical protein NP_821733.1 707738 D 227882 CDS NP_821734.1 29827100 1212276 708335..708796 1 NC_003155.4 hypothetical protein 708796 1212276 SAV_559 Streptomyces avermitilis MA-4680 hypothetical protein NP_821734.1 708335 D 227882 CDS NP_821735.1 29827101 1212277 709185..710330 1 NC_003155.4 PF03824: High-affinity nickel-transport protein; high-affinity nickel-transport protein 710330 nicT1 1212277 nicT1 Streptomyces avermitilis MA-4680 high-affinity nickel-transport protein NP_821735.1 709185 D 227882 CDS NP_821736.1 29827102 1212278 complement(710518..711135) 1 NC_003155.4 PF00881: Nitroreductase family; hypothetical protein 711135 1212278 SAV_561 Streptomyces avermitilis MA-4680 hypothetical protein NP_821736.1 710518 R 227882 CDS NP_821737.1 29827103 1210054 complement(711283..713301) 1 NC_003155.4 AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase; acetoacetyl-CoA synthetase 713301 acsA3 1210054 acsA3 Streptomyces avermitilis MA-4680 acetoacetyl-CoA synthetase NP_821737.1 711283 R 227882 CDS NP_821738.1 29827104 1210055 complement(713315..714925) 1 NC_003155.4 catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate hydroxylase 714925 mhpA 1210055 mhpA Streptomyces avermitilis MA-4680 3-(3-hydroxyphenyl)propionate hydroxylase NP_821738.1 713315 R 227882 CDS NP_821739.1 29827105 1212279 complement(714922..715860) 1 NC_003155.4 PF01557: Fumarylacetoacetate (FAA) hydrolase family; 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase 715860 1212279 SAV_564 Streptomyces avermitilis MA-4680 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase NP_821739.1 714922 R 227882 CDS NP_821740.1 29827106 1210056 complement(715857..716894) 1 NC_003155.4 2,3-dihydroxybiphenyl-1,2-dioxygenase 716894 bphC 1210056 bphC Streptomyces avermitilis MA-4680 2,3-dihydroxybiphenyl-1,2-dioxygenase NP_821740.1 715857 R 227882 CDS NP_821741.1 29827107 1212280 717140..717775 1 NC_003155.4 TetR family transcriptional regulator 717775 1212280 SAV_566 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_821741.1 717140 D 227882 CDS NP_821742.1 29827108 1212281 717968..719413 1 NC_003155.4 PF01590: GAF domain; hypothetical protein 719413 1212281 SAV_567 Streptomyces avermitilis MA-4680 hypothetical protein NP_821742.1 717968 D 227882 CDS NP_821743.1 29827109 1212282 719128..720147 1 NC_003155.4 PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; magnesium or manganese-dependent protein phosphatase 720147 prpI1 1212282 prpI1 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_821743.1 719128 D 227882 CDS NP_821744.1 29827110 1212283 720606..721364 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 721364 1212283 SAV_569 Streptomyces avermitilis MA-4680 hydrolase NP_821744.1 720606 D 227882 CDS NP_821745.1 29827111 1212284 721705..722091 1 NC_003155.4 PF04686: Streptomyces sporulation and cell division protein, SsgA; cell division protein, regulatory protein 722091 ssgA3 1212284 ssgA3 Streptomyces avermitilis MA-4680 cell division protein, regulatory protein NP_821745.1 721705 D 227882 CDS NP_821746.1 29827112 1212285 722855..723661 1 NC_003155.4 PF03691: Uncharacterised protein family (UPF0167); hypothetical protein 723661 1212285 SAV_571 Streptomyces avermitilis MA-4680 hypothetical protein NP_821746.1 722855 D 227882 CDS NP_821747.1 29827113 1212286 complement(723643..724497) 1 NC_003155.4 PF07287: Protein of unknown function (DUF1446); hypothetical protein 724497 1212286 SAV_572 Streptomyces avermitilis MA-4680 hypothetical protein NP_821747.1 723643 R 227882 CDS NP_821748.1 29827114 1212287 complement(724687..725370) 1 NC_003155.4 hypothetical protein 725370 1212287 SAV_573 Streptomyces avermitilis MA-4680 hypothetical protein NP_821748.1 724687 R 227882 CDS NP_821749.1 29827115 1212288 complement(725598..726644) 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 726644 1212288 SAV_574 Streptomyces avermitilis MA-4680 dehydrogenase NP_821749.1 725598 R 227882 CDS NP_821750.1 29827116 1210057 complement(726776..729997) 1 NC_003155.4 CYP102D1, bifunctional P450:NADPH-P450 reductase; cytochrome P450 729997 cyp2 1210057 cyp2 Streptomyces avermitilis MA-4680 cytochrome P450 NP_821750.1 726776 R 227882 CDS NP_821751.1 29827117 1212289 730897..731553 1 NC_003155.4 TetR family transcriptional regulator 731553 1212289 SAV_576 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_821751.1 730897 D 227882 CDS NP_821752.1 29827118 1212290 complement(732025..732822) 1 NC_003155.4 TetR family transcriptional regulator 732822 1212290 SAV_577 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_821752.1 732025 R 227882 CDS NP_821753.1 29827119 1212291 complement(733207..733389) 1 NC_003155.4 hypothetical protein 733389 1212291 SAV_578 Streptomyces avermitilis MA-4680 hypothetical protein NP_821753.1 733207 R 227882 CDS NP_821754.1 29827120 1212292 complement(734105..734434) 1 NC_003155.4 hypothetical protein 734434 1212292 SAV_579 Streptomyces avermitilis MA-4680 hypothetical protein NP_821754.1 734105 R 227882 CDS NP_821755.1 29827121 1212293 complement(734503..734922) 1 NC_003155.4 PF04686: Streptomyces sporulation and cell division protein, SsgA; cell division protein, regulatory protein 734922 ssgA4 1212293 ssgA4 Streptomyces avermitilis MA-4680 cell division protein, regulatory protein NP_821755.1 734503 R 227882 CDS NP_821756.1 29827122 1212294 complement(734950..735294) 1 NC_003155.4 hypothetical protein 735294 1212294 SAV_581 Streptomyces avermitilis MA-4680 hypothetical protein NP_821756.1 734950 R 227882 CDS NP_821757.1 29827123 1210058 735716..735925 1 NC_003155.4 ferredoxin 735925 fdxA 1210058 fdxA Streptomyces avermitilis MA-4680 ferredoxin NP_821757.1 735716 D 227882 CDS NP_821758.1 29827124 1210059 735915..737279 1 NC_003155.4 ferredoxin reductase 737279 fprA 1210059 fprA Streptomyces avermitilis MA-4680 ferredoxin reductase NP_821758.1 735915 D 227882 CDS NP_821759.1 29827125 1210060 737312..738511 1 NC_003155.4 CYP147B1, fdxA and fprA are located at upstream; cytochrome P450 738511 cyp3 1210060 cyp3 Streptomyces avermitilis MA-4680 cytochrome P450 NP_821759.1 737312 D 227882 CDS NP_821760.1 29827126 1212295 complement(738601..739236) 1 NC_003155.4 TetR family transcriptional regulator 739236 1212295 SAV_585 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_821760.1 738601 R 227882 CDS NP_821761.1 29827127 1212296 739502..741964 1 NC_003155.4 PF00989: PAS domain, PF01590: GAF domain; magnesium or manganese-dependent protein phosphatase 741964 prpL1 1212296 prpL1 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_821761.1 739502 D 227882 CDS NP_821762.1 29827128 1212297 742052..744481 1 NC_003155.4 PF01590: GAF domain; magnesium or manganese-dependent protein phosphatase 744481 prpJ1 1212297 prpJ1 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_821762.1 742052 D 227882 CDS NP_821763.1 29827129 1212298 complement(744841..745287) 1 NC_003155.4 transcription regulator AsnC 745287 1212298 SAV_588 Streptomyces avermitilis MA-4680 transcription regulator AsnC NP_821763.1 744841 R 227882 CDS NP_821764.1 29827130 1212299 745381..746199 1 NC_003155.4 PF00296: Luciferase-like monooxygenase; F420-dependent dehydrogenase 746199 1212299 SAV_589 Streptomyces avermitilis MA-4680 F420-dependent dehydrogenase NP_821764.1 745381 D 227882 CDS NP_821765.1 29827131 1212300 746196..746633 1 NC_003155.4 PF00383: Cytidine and deoxycytidylate deaminase zinc-binding region; cytidine/deoxycytidine deaminase 746633 cdd1 1212300 cdd1 Streptomyces avermitilis MA-4680 cytidine/deoxycytidine deaminase NP_821765.1 746196 D 227882 CDS NP_821766.1 29827132 1210061 complement(746752..747162) 1 NC_003155.4 gas vesicle synthesis protein 747162 gvpK1 1210061 gvpK1 Streptomyces avermitilis MA-4680 gas vesicle synthesis protein NP_821766.1 746752 R 227882 CDS NP_821767.1 29827133 1210062 complement(747159..747446) 1 NC_003155.4 gas vesicle synthesis protein 747446 gvpS1 1210062 gvpS1 Streptomyces avermitilis MA-4680 gas vesicle synthesis protein NP_821767.1 747159 R 227882 CDS NP_821768.1 29827134 1210063 complement(747446..748261) 1 NC_003155.4 gas vesicle synthesis protein 748261 gvpL1 1210063 gvpL1 Streptomyces avermitilis MA-4680 gas vesicle synthesis protein NP_821768.1 747446 R 227882 CDS NP_821769.1 29827135 1210064 complement(748258..748707) 1 NC_003155.4 gas vesicle synthesis protein 748707 gvpJ1 1210064 gvpJ1 Streptomyces avermitilis MA-4680 gas vesicle synthesis protein NP_821769.1 748258 R 227882 CDS NP_821770.1 29827136 1212301 complement(748704..748928) 1 NC_003155.4 hypothetical protein 748928 1212301 SAV_595 Streptomyces avermitilis MA-4680 hypothetical protein NP_821770.1 748704 R 227882 CDS NP_821771.1 29827137 1210065 complement(748925..749176) 1 NC_003155.4 gas vesicle synthesis protein 749176 gvpG1 1210065 gvpG1 Streptomyces avermitilis MA-4680 gas vesicle synthesis protein NP_821771.1 748925 R 227882 CDS NP_821772.1 29827138 1210066 complement(749194..749916) 1 NC_003155.4 gas vesicle synthesis protein 749916 gvpF1 1210066 gvpF1 Streptomyces avermitilis MA-4680 gas vesicle synthesis protein NP_821772.1 749194 R 227882 CDS NP_821773.1 29827139 1210067 complement(749920..750369) 1 NC_003155.4 similar to the gas vesicle synthesis protein GvpA in other bacteria but contains an extended C-terminal tail; function in the Streptomyces group is unknown but they contain several homologs of other gas vesicle synthesis proteins; gas vesicle synthesis-like protein 750369 gvpA1 1210067 gvpA1 Streptomyces avermitilis MA-4680 gas vesicle synthesis-like protein NP_821773.1 749920 R 227882 CDS NP_821774.1 29827140 1210068 complement(750480..750848) 1 NC_003155.4 gas vesicle synthesis protein 750848 gvpO1 1210068 gvpO1 Streptomyces avermitilis MA-4680 gas vesicle synthesis protein NP_821774.1 750480 R 227882 CDS NP_821775.1 29827141 1212302 complement(751402..752148) 1 NC_003155.4 PF00005: ABC transporter; Fe+3/siderophore ABC transporter transport system ATP-binding protein 752148 fecC 1212302 fecC Streptomyces avermitilis MA-4680 Fe+3/siderophore ABC transporter transport system ATP-binding protein NP_821775.1 751402 R 227882 CDS NP_821776.1 29827142 1212303 complement(752205..753176) 1 NC_003155.4 PF01032: FecCD transport family; Fe+3/siderophore ABC transporter permease 753176 fecD 1212303 fecD Streptomyces avermitilis MA-4680 Fe+3/siderophore ABC transporter permease NP_821776.1 752205 R 227882 CDS NP_821777.1 29827143 1212304 complement(753242..754285) 1 NC_003155.4 PF01497: Periplasmic binding protein; Fe+3/siderophore ABC transporter -binding protein 754285 fecB 1212304 fecB Streptomyces avermitilis MA-4680 Fe+3/siderophore ABC transporter -binding protein NP_821777.1 753242 R 227882 CDS NP_821778.1 29827144 1212305 complement(754376..758698) 1 NC_003155.4 nrps6 gene cluster; non-ribosomal peptide synthetase 758698 nrps6 1212305 nrps6 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_821778.1 754376 R 227882 CDS NP_821779.1 29827145 1212306 complement(758706..758963) 1 NC_003155.4 nrps6 gene cluster, PF00550: Phosphopantetheine attachment site; hypothetical protein 758963 1212306 SAV_604 Streptomyces avermitilis MA-4680 hypothetical protein NP_821779.1 758706 R 227882 CDS NP_821780.1 29827146 1210069 complement(758996..760552) 1 NC_003155.4 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 760552 fadD2 1210069 fadD2 Streptomyces avermitilis MA-4680 long-chain-fatty-acid--CoA ligase NP_821780.1 758996 R 227882 CDS NP_821781.1 29827147 1212307 complement(760605..761123) 1 NC_003155.4 nrps6 gene cluster; hypothetical protein 761123 1212307 SAV_606 Streptomyces avermitilis MA-4680 hypothetical protein NP_821781.1 760605 R 227882 CDS NP_821782.1 29827148 1212308 complement(761120..762010) 1 NC_003155.4 nrps6 gene cluster, PF02668: Taurine catabolism dioxygenase TauD, TfdA family; taurine catabolism dioxygenase 762010 1212308 SAV_607 Streptomyces avermitilis MA-4680 taurine catabolism dioxygenase NP_821782.1 761120 R 227882 CDS NP_821783.1 29827149 1210070 complement(762046..762285) 1 NC_003155.4 nrps6 gene cluster, PF00550: Phosphopantetheine attachment site; ACP 762285 fabC2 1210070 fabC2 Streptomyces avermitilis MA-4680 ACP NP_821783.1 762046 R 227882 CDS NP_821784.2 161511223 1210071 complement(762282..763352) 1 NC_003155.4 FabH; beta-ketoacyl-ACP synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-ACP synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase III 763352 fabH4 1210071 fabH4 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP synthase III NP_821784.2 762282 R 227882 CDS NP_821785.1 29827151 1212309 complement(763424..764821) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; MFS transporter protein 764821 1212309 SAV_610 Streptomyces avermitilis MA-4680 MFS transporter protein NP_821785.1 763424 R 227882 CDS NP_821786.1 29827152 1212310 complement(765101..765853) 1 NC_003155.4 PF05118: Aspartyl/Asparaginyl beta-hydroxylase; beta-hydroxylase 765853 1212310 SAV_611 Streptomyces avermitilis MA-4680 beta-hydroxylase NP_821786.1 765101 R 227882 CDS NP_821787.1 29827153 1212311 complement(765882..766415) 1 NC_003155.4 hypothetical protein 766415 1212311 SAV_612 Streptomyces avermitilis MA-4680 hypothetical protein NP_821787.1 765882 R 227882 CDS NP_821788.1 29827154 1212312 767298..767819 1 NC_003155.4 PF04314: Protein of unknown function (DUF461); hypothetical protein 767819 1212312 SAV_613 Streptomyces avermitilis MA-4680 hypothetical protein NP_821788.1 767298 D 227882 CDS NP_821789.1 29827155 1210072 complement(767899..768552) 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 768552 sig5 1210072 sig5 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_821789.1 767899 R 227882 CDS NP_821790.1 29827156 1212313 complement(768752..769429) 1 NC_003155.4 hypothetical protein 769429 1212313 SAV_615 Streptomyces avermitilis MA-4680 hypothetical protein NP_821790.1 768752 R 227882 CDS NP_821791.1 29827157 1212314 complement(769580..770101) 1 NC_003155.4 PF04314: Protein of unknown function (DUF461); hypothetical protein 770101 1212314 SAV_616 Streptomyces avermitilis MA-4680 hypothetical protein NP_821791.1 769580 R 227882 CDS NP_821792.1 29827158 1210073 complement(770098..772353) 1 NC_003155.4 PF00122: E1-E2 ATPase; cation-transporting P-type ATPase 772353 ctpB 1210073 ctpB Streptomyces avermitilis MA-4680 cation-transporting P-type ATPase NP_821792.1 770098 R 227882 CDS NP_821793.1 29827159 1212315 complement(772353..772664) 1 NC_003155.4 hypothetical protein 772664 1212315 SAV_618 Streptomyces avermitilis MA-4680 hypothetical protein NP_821793.1 772353 R 227882 CDS NP_821794.1 29827160 1212316 complement(773199..773498) 1 NC_003155.4 hypothetical protein 773498 1212316 SAV_619 Streptomyces avermitilis MA-4680 hypothetical protein NP_821794.1 773199 R 227882 CDS NP_821795.1 29827161 1212317 complement(773556..774389) 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 774389 1212317 SAV_620 Streptomyces avermitilis MA-4680 hydrolase NP_821795.1 773556 R 227882 CDS NP_821796.1 29827162 1212318 774469..774984 1 NC_003155.4 MarR family transcriptional regulator 774984 1212318 SAV_621 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_821796.1 774469 D 227882 CDS NP_821797.1 29827163 1212319 775498..775956 1 NC_003155.4 hypothetical protein 775956 1212319 SAV_622 Streptomyces avermitilis MA-4680 hypothetical protein NP_821797.1 775498 D 227882 CDS NP_821798.1 29827164 1212320 776002..776298 1 NC_003155.4 LuxR family transcriptional regulator 776298 1212320 SAV_623 Streptomyces avermitilis MA-4680 LuxR family transcriptional regulator NP_821798.1 776002 D 227882 CDS NP_821799.1 29827165 1212321 complement(776473..777039) 1 NC_003155.4 hypothetical protein 777039 1212321 SAV_624 Streptomyces avermitilis MA-4680 hypothetical protein NP_821799.1 776473 R 227882 CDS NP_821800.1 29827166 1212322 777216..778127 1 NC_003155.4 LysR family transcriptional regulator 778127 1212322 SAV_625 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_821800.1 777216 D 227882 CDS NP_821801.1 29827167 1212323 778334..779140 1 NC_003155.4 hypothetical protein 779140 1212323 SAV_626 Streptomyces avermitilis MA-4680 hypothetical protein NP_821801.1 778334 D 227882 CDS NP_821802.1 29827168 1212324 complement(779554..781029) 1 NC_003155.4 PF03663: Glycosyl hydrolase family 76; glycosyl hydrolase 781029 1212324 SAV_627 Streptomyces avermitilis MA-4680 glycosyl hydrolase NP_821802.1 779554 R 227882 CDS NP_821803.1 29827169 1210074 complement(781050..782660) 1 NC_003155.4 alpha-galactosidase 782660 agaA1 1210074 agaA1 Streptomyces avermitilis MA-4680 alpha-galactosidase NP_821803.1 781050 R 227882 CDS NP_821804.1 29827170 1212325 782844..783239 1 NC_003155.4 hypothetical protein 783239 1212325 SAV_629 Streptomyces avermitilis MA-4680 hypothetical protein NP_821804.1 782844 D 227882 CDS NP_821805.1 29827171 1212326 complement(783885..784940) 1 NC_003155.4 LacI family transcriptional regulator 784940 1212326 SAV_630 Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_821805.1 783885 R 227882 CDS NP_821806.1 29827172 1212327 complement(785031..785402) 1 NC_003155.4 hypothetical protein 785402 1212327 SAV_632 Streptomyces avermitilis MA-4680 hypothetical protein NP_821806.1 785031 R 227882 CDS NP_821807.1 29827173 1212328 785356..785871 1 NC_003155.4 PF00754: F5/8 type C domain; hypothetical protein 785871 1212328 SAV_631 Streptomyces avermitilis MA-4680 hypothetical protein NP_821807.1 785356 D 227882 CDS NP_821808.1 29827174 1212329 786451..786915 1 NC_003155.4 hypothetical protein 786915 1212329 SAV_633 Streptomyces avermitilis MA-4680 hypothetical protein NP_821808.1 786451 D 227882 CDS NP_821809.1 29827175 1212330 788248..789312 1 NC_003155.4 IS110 family; IS110 family transposase 789312 1212330 SAV_634 Streptomyces avermitilis MA-4680 IS110 family transposase NP_821809.1 788248 D 227882 CDS NP_821810.1 29827176 1210075 complement(789498..790355) 1 NC_003155.4 enoyl-CoA hydratase 790355 echA2 1210075 echA2 Streptomyces avermitilis MA-4680 enoyl-CoA hydratase NP_821810.1 789498 R 227882 CDS NP_821811.1 29827177 1212331 complement(790843..791451) 1 NC_003155.4 PF01965: DJ-1/PfpI family; AraC family transcription regulator 791451 1212331 SAV_636 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_821811.1 790843 R 227882 CDS NP_821812.1 29827178 1212332 complement(792236..792676) 1 NC_003155.4 hypothetical protein 792676 1212332 SAV_637 Streptomyces avermitilis MA-4680 hypothetical protein NP_821812.1 792236 R 227882 CDS NP_821813.1 29827179 1212333 793192..794145 1 NC_003155.4 hypothetical protein 794145 1212333 SAV_638 Streptomyces avermitilis MA-4680 hypothetical protein NP_821813.1 793192 D 227882 CDS NP_821814.1 29827180 1210076 complement(794749..795285) 1 NC_003155.4 serine/threonine protein kinase 795285 pkn1 1210076 pkn1 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_821814.1 794749 R 227882 CDS NP_821815.1 29827181 1212334 796901..797425 1 NC_003155.4 hypothetical protein 797425 1212334 SAV_640 Streptomyces avermitilis MA-4680 hypothetical protein NP_821815.1 796901 D 227882 CDS NP_821816.1 29827182 1212335 797764..798072 1 NC_003155.4 hypothetical protein 798072 1212335 SAV_641 Streptomyces avermitilis MA-4680 hypothetical protein NP_821816.1 797764 D 227882 CDS NP_821817.1 29827183 1212336 complement(798051..801284) 1 NC_003155.4 PF05729: NACHT domain; hypothetical protein 801284 1212336 SAV_642 Streptomyces avermitilis MA-4680 hypothetical protein NP_821817.1 798051 R 227882 CDS NP_821818.1 29827184 1212337 complement(801354..801581) 1 NC_003155.4 hypothetical protein 801581 1212337 SAV_643 Streptomyces avermitilis MA-4680 hypothetical protein NP_821818.1 801354 R 227882 CDS NP_821819.1 29827185 1212338 802775..803185 1 NC_003155.4 hypothetical protein 803185 1212338 SAV_644 Streptomyces avermitilis MA-4680 hypothetical protein NP_821819.1 802775 D 227882 CDS NP_821820.1 29827186 1212339 complement(803307..803486) 1 NC_003155.4 hypothetical protein 803486 1212339 SAV_645 Streptomyces avermitilis MA-4680 hypothetical protein NP_821820.1 803307 R 227882 CDS NP_821821.1 29827187 1212340 complement(803533..804099) 1 NC_003155.4 frameshift; two-component system sensor kinase 804099 1212340 SAV_646 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_821821.1 803533 R 227882 CDS NP_821822.1 29827188 1212341 complement(804165..804863) 1 NC_003155.4 frameshift; sensor kinase 804863 1212341 SAV_647 Streptomyces avermitilis MA-4680 sensor kinase NP_821822.1 804165 R 227882 CDS NP_821823.1 29827189 1212342 complement(804917..805603) 1 NC_003155.4 two-component system response regulator 805603 1212342 SAV_648 Streptomyces avermitilis MA-4680 two-component system response regulator NP_821823.1 804917 R 227882 CDS NP_821824.1 29827190 1212343 complement(806100..806720) 1 NC_003155.4 similar to aminonucleoside antibiotic A201A phosphotransferase; phosphotransferase (aminonucleoside antibiotic resistance) 806720 ard 1212343 ard Streptomyces avermitilis MA-4680 phosphotransferase (aminonucleoside antibiotic resistance) NP_821824.1 806100 R 227882 CDS NP_821825.1 29827191 1212344 807493..808398 1 NC_003155.4 methyltransferase 808398 1212344 SAV_650 Streptomyces avermitilis MA-4680 methyltransferase NP_821825.1 807493 D 227882 CDS NP_821826.1 29827192 1212345 complement(808509..808670) 1 NC_003155.4 hypothetical protein 808670 1212345 SAV_651 Streptomyces avermitilis MA-4680 hypothetical protein NP_821826.1 808509 R 227882 CDS NP_821827.1 29827193 1212346 complement(809624..810859) 1 NC_003155.4 probable membrane efflux protein, PF07690: Major Facilitator Superfamily; fosmidmycin resistance protein 810859 1212346 SAV_652 Streptomyces avermitilis MA-4680 fosmidmycin resistance protein NP_821827.1 809624 R 227882 CDS NP_821828.1 29827194 1212347 810866..811657 1 NC_003155.4 PF00165: Bacterial regulatory helix-turn-helix proteins, araC family; AraC family transcription regulator 811657 1212347 SAV_653 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_821828.1 810866 D 227882 CDS NP_821829.1 29827195 1212348 complement(811793..812788) 1 NC_003155.4 PF00248: Aldo/keto reductase family; oxidoreductase 812788 1212348 SAV_654 Streptomyces avermitilis MA-4680 oxidoreductase NP_821829.1 811793 R 227882 CDS NP_821830.1 29827196 1212349 812915..813775 1 NC_003155.4 DNA-binding protein 813775 1212349 SAV_655 Streptomyces avermitilis MA-4680 DNA-binding protein NP_821830.1 812915 D 227882 CDS NP_821831.1 29827197 1212350 complement(813831..814319) 1 NC_003155.4 hypothetical protein 814319 1212350 SAV_656 Streptomyces avermitilis MA-4680 hypothetical protein NP_821831.1 813831 R 227882 CDS NP_821832.1 29827198 1212351 complement(814839..815231) 1 NC_003155.4 hypothetical protein 815231 1212351 SAV_657 Streptomyces avermitilis MA-4680 hypothetical protein NP_821832.1 814839 R 227882 CDS NP_821833.1 29827199 1212352 complement(815233..816663) 1 NC_003155.4 hypothetical protein 816663 1212352 SAV_658 Streptomyces avermitilis MA-4680 hypothetical protein NP_821833.1 815233 R 227882 CDS NP_821834.1 29827200 1212353 complement(817263..818171) 1 NC_003155.4 AraC family transcription regulator 818171 1212353 SAV_659 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_821834.1 817263 R 227882 CDS NP_821835.1 29827201 1210077 818311..818904 1 NC_003155.4 PF00753: Metallo-beta-lactamase superfamily; metallo-beta-lactamase 818904 blaB1 1210077 blaB1 Streptomyces avermitilis MA-4680 metallo-beta-lactamase NP_821835.1 818311 D 227882 CDS NP_821836.1 29827202 1212354 complement(818939..819619) 1 NC_003155.4 hypothetical protein 819619 1212354 SAV_661 Streptomyces avermitilis MA-4680 hypothetical protein NP_821836.1 818939 R 227882 CDS NP_821837.1 29827203 1212355 complement(819960..820334) 1 NC_003155.4 hypothetical protein 820334 1212355 SAV_662 Streptomyces avermitilis MA-4680 hypothetical protein NP_821837.1 819960 R 227882 CDS NP_821838.1 29827204 1210078 820435..821349 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 821349 sig6 1210078 sig6 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_821838.1 820435 D 227882 CDS NP_821839.1 29827205 1212356 821389..822165 1 NC_003155.4 methyltransferase 822165 1212356 SAV_664 Streptomyces avermitilis MA-4680 methyltransferase NP_821839.1 821389 D 227882 CDS NP_821840.1 29827206 1210079 complement(822808..823653) 1 NC_003155.4 PF00106: short chain dehydrogenase; 3-oxoacyl-ACP reductase 823653 fabG1 1210079 fabG1 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP reductase NP_821840.1 822808 R 227882 CDS NP_821841.1 29827207 1212357 complement(824426..824581) 1 NC_003155.4 hypothetical protein 824581 1212357 SAV_666 Streptomyces avermitilis MA-4680 hypothetical protein NP_821841.1 824426 R 227882 CDS NP_821842.1 29827208 1212358 complement(824979..826418) 1 NC_003155.4 similar to dihydrolipoamide dehydrogenase, PF00070: Pyridine nucleotide-disulphide oxidoreductase; oxidoreductase 826418 lpdB1 1212358 lpdB1 Streptomyces avermitilis MA-4680 oxidoreductase NP_821842.1 824979 R 227882 CDS NP_821843.1 29827209 1212359 complement(826839..827309) 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; lyase 827309 1212359 SAV_668 Streptomyces avermitilis MA-4680 lyase NP_821843.1 826839 R 227882 CDS NP_821844.1 29827210 1212360 827554..828144 1 NC_003155.4 TetR family transcriptional regulator 828144 1212360 SAV_669 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_821844.1 827554 D 227882 CDS NP_821845.1 29827211 1212361 complement(828242..829534) 1 NC_003155.4 PF01609: Transposase DDE domain; transposase 829534 insA 1212361 insA Streptomyces avermitilis MA-4680 transposase NP_821845.1 828242 R 227882 CDS NP_821846.1 29827212 1212362 829572..830048 1 NC_003155.4 PF02452: PemK-like protein; hypothetical protein 830048 1212362 SAV_671 Streptomyces avermitilis MA-4680 hypothetical protein NP_821846.1 829572 D 227882 CDS NP_821847.1 29827213 1212363 830486..830860 1 NC_003155.4 hypothetical protein 830860 1212363 SAV_672 Streptomyces avermitilis MA-4680 hypothetical protein NP_821847.1 830486 D 227882 CDS NP_821848.1 29827214 1212364 830882..831715 1 NC_003155.4 hypothetical protein 831715 1212364 SAV_673 Streptomyces avermitilis MA-4680 hypothetical protein NP_821848.1 830882 D 227882 CDS NP_821849.1 29827215 1212365 831803..832024 1 NC_003155.4 hypothetical protein 832024 1212365 SAV_674 Streptomyces avermitilis MA-4680 hypothetical protein NP_821849.1 831803 D 227882 CDS NP_821850.1 29827216 1212366 complement(832592..833383) 1 NC_003155.4 TetR family transcriptional regulator 833383 1212366 SAV_675 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_821850.1 832592 R 227882 CDS NP_821851.1 29827217 1212367 833510..834505 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 834505 1212367 SAV_676 Streptomyces avermitilis MA-4680 dehydrogenase NP_821851.1 833510 D 227882 CDS NP_821852.1 29827218 1212368 complement(834687..835604) 1 NC_003155.4 PF05200: Glutamyl-tRNAGlu reductase, NAD(P) binding domain; dehydrogenase 835604 1212368 SAV_677 Streptomyces avermitilis MA-4680 dehydrogenase NP_821852.1 834687 R 227882 CDS NP_821853.1 29827219 1212369 835665..836027 1 NC_003155.4 PF01638: Transcriptional regulator; transcriptional regulator 836027 1212369 SAV_678 Streptomyces avermitilis MA-4680 transcriptional regulator NP_821853.1 835665 D 227882 CDS NP_821854.1 29827220 1212370 836553..836768 1 NC_003155.4 hypothetical protein 836768 1212370 SAV_679 Streptomyces avermitilis MA-4680 hypothetical protein NP_821854.1 836553 D 227882 CDS NP_821855.1 29827221 1212371 837091..837753 1 NC_003155.4 hypothetical protein 837753 1212371 SAV_680 Streptomyces avermitilis MA-4680 hypothetical protein NP_821855.1 837091 D 227882 CDS NP_821856.1 29827222 1212372 837899..838645 1 NC_003155.4 PF01636: Phosphotransferase enzyme family; phosphotransferase 838645 1212372 SAV_681 Streptomyces avermitilis MA-4680 phosphotransferase NP_821856.1 837899 D 227882 CDS NP_821857.1 29827223 1212373 complement(838664..838882) 1 NC_003155.4 IS5 family; hypothetical protein 838882 1212373 SAV_682 Streptomyces avermitilis MA-4680 hypothetical protein NP_821857.1 838664 R 227882 CDS NP_821858.1 29827224 1212374 complement(839061..839342) 1 NC_003155.4 transposase 839342 1212374 SAV_683 Streptomyces avermitilis MA-4680 transposase NP_821858.1 839061 R 227882 CDS NP_821859.1 29827225 1212375 complement(839489..839665) 1 NC_003155.4 hypothetical protein 839665 1212375 SAV_684 Streptomyces avermitilis MA-4680 hypothetical protein NP_821859.1 839489 R 227882 CDS NP_821860.1 29827226 1212376 complement(839801..840232) 1 NC_003155.4 hypothetical protein 840232 1212376 SAV_685 Streptomyces avermitilis MA-4680 hypothetical protein NP_821860.1 839801 R 227882 CDS NP_821861.1 29827227 1212377 840508..840777 1 NC_003155.4 hypothetical protein 840777 1212377 SAV_686 Streptomyces avermitilis MA-4680 hypothetical protein NP_821861.1 840508 D 227882 CDS NP_821862.1 29827228 1212378 840896..841369 1 NC_003155.4 PF03794: Domain of Unknown function; hypothetical protein 841369 1212378 SAV_687 Streptomyces avermitilis MA-4680 hypothetical protein NP_821862.1 840896 D 227882 CDS NP_821863.1 29827229 1212379 842362..842616 1 NC_003155.4 hypothetical protein 842616 1212379 SAV_688 Streptomyces avermitilis MA-4680 hypothetical protein NP_821863.1 842362 D 227882 CDS NP_821864.1 29827230 1212380 complement(842970..843443) 1 NC_003155.4 hypothetical protein 843443 1212380 SAV_689 Streptomyces avermitilis MA-4680 hypothetical protein NP_821864.1 842970 R 227882 CDS NP_821865.1 29827231 1212381 843495..843770 1 NC_003155.4 transposase 843770 1212381 SAV_690 Streptomyces avermitilis MA-4680 transposase NP_821865.1 843495 D 227882 CDS NP_821866.1 29827232 1212382 complement(843915..844562) 1 NC_003155.4 hsp18 transcriptional regulator 844562 1212382 SAV_691 Streptomyces avermitilis MA-4680 hsp18 transcriptional regulator NP_821866.1 843915 R 227882 CDS NP_821867.1 29827233 1210080 844710..845141 1 NC_003155.4 heat shock protein 845141 hsp18 1210080 hsp18 Streptomyces avermitilis MA-4680 heat shock protein NP_821867.1 844710 D 227882 CDS NP_821868.1 29827234 1212383 complement(846848..847663) 1 NC_003155.4 hypothetical protein 847663 1212383 SAV_693 Streptomyces avermitilis MA-4680 hypothetical protein NP_821868.1 846848 R 227882 CDS NP_821869.1 29827235 1212384 complement(848379..849155) 1 NC_003155.4 ABC transporter permease 849155 1212384 SAV_694 Streptomyces avermitilis MA-4680 ABC transporter permease NP_821869.1 848379 R 227882 CDS NP_821870.1 29827236 1212385 complement(849152..850117) 1 NC_003155.4 ABC transporter ATP-binding protein 850117 1212385 SAV_695 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_821870.1 849152 R 227882 CDS NP_821871.1 29827237 1212386 complement(850165..850836) 1 NC_003155.4 hypothetical protein 850836 1212386 SAV_696 Streptomyces avermitilis MA-4680 hypothetical protein NP_821871.1 850165 R 227882 CDS NP_821872.1 29827238 1212387 851082..851816 1 NC_003155.4 PF01047: MarR family; hypothetical protein 851816 1212387 SAV_697 Streptomyces avermitilis MA-4680 hypothetical protein NP_821872.1 851082 D 227882 CDS NP_821873.1 29827239 1212388 complement(851975..853549) 1 NC_003155.4 PF00989: PAS domain; magnesium or manganese-dependent protein phosphatase 853549 prpC1 1212388 prpC1 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_821873.1 851975 R 227882 CDS NP_821874.1 29827240 1212389 853859..854782 1 NC_003155.4 PF00106: short chain dehydrogenase; short chain dehydrogenase 854782 1212389 SAV_699 Streptomyces avermitilis MA-4680 short chain dehydrogenase NP_821874.1 853859 D 227882 CDS NP_821875.1 29827241 1210081 854938..855585 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 855585 sig7 1210081 sig7 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_821875.1 854938 D 227882 CDS NP_821876.1 29827242 1212390 855582..856205 1 NC_003155.4 hypothetical protein 856205 1212390 SAV_701 Streptomyces avermitilis MA-4680 hypothetical protein NP_821876.1 855582 D 227882 CDS NP_821877.1 29827243 1212391 856474..857739 1 NC_003155.4 PF01757: Acyltransferase family; acyltransferase 857739 1212391 SAV_702 Streptomyces avermitilis MA-4680 acyltransferase NP_821877.1 856474 D 227882 CDS NP_821878.1 29827244 1212392 858470..859033 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 859033 1212392 SAV_703 Streptomyces avermitilis MA-4680 acetyltransferase NP_821878.1 858470 D 227882 CDS NP_821879.1 29827245 1212393 859191..859688 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 859688 1212393 SAV_704 Streptomyces avermitilis MA-4680 acetyltransferase NP_821879.1 859191 D 227882 CDS NP_821880.1 29827246 1212394 860134..860766 1 NC_003155.4 TetR family transcriptional regulator 860766 1212394 SAV_705 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_821880.1 860134 D 227882 CDS NP_821881.1 29827247 1212395 complement(861137..862141) 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 862141 1212395 SAV_706 Streptomyces avermitilis MA-4680 dehydrogenase NP_821881.1 861137 R 227882 CDS NP_821882.1 29827248 1212396 complement(862181..862846) 1 NC_003155.4 PF03807: NADP oxidoreductase coenzyme F420-dependent; hypothetical protein 862846 1212396 SAV_707 Streptomyces avermitilis MA-4680 hypothetical protein NP_821882.1 862181 R 227882 CDS NP_821883.1 29827249 1212397 complement(862995..863978) 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 863978 1212397 SAV_708 Streptomyces avermitilis MA-4680 dehydrogenase NP_821883.1 862995 R 227882 CDS NP_821884.1 29827250 1212398 complement(864552..864953) 1 NC_003155.4 hypothetical protein 864953 1212398 SAV_709 Streptomyces avermitilis MA-4680 hypothetical protein NP_821884.1 864552 R 227882 CDS NP_821885.1 29827251 1212399 complement(864970..865173) 1 NC_003155.4 hypothetical protein 865173 1212399 SAV_710 Streptomyces avermitilis MA-4680 hypothetical protein NP_821885.1 864970 R 227882 CDS NP_821886.1 29827252 1212400 complement(865372..865893) 1 NC_003155.4 PF01638: Transcriptional regulator; transcriptional regulator 865893 1212400 SAV_711 Streptomyces avermitilis MA-4680 transcriptional regulator NP_821886.1 865372 R 227882 CDS NP_821887.1 29827253 1212401 complement(865902..866057) 1 NC_003155.4 hypothetical protein 866057 1212401 SAV_712 Streptomyces avermitilis MA-4680 hypothetical protein NP_821887.1 865902 R 227882 CDS NP_821888.1 29827254 1212402 complement(866302..866511) 1 NC_003155.4 truncated; transposase 866511 1212402 SAV_713 Streptomyces avermitilis MA-4680 transposase NP_821888.1 866302 R 227882 CDS NP_821889.1 29827255 1212403 complement(866655..867341) 1 NC_003155.4 phosphatase 867341 1212403 SAV_714 Streptomyces avermitilis MA-4680 phosphatase NP_821889.1 866655 R 227882 CDS NP_821890.1 29827256 1212404 complement(867789..868694) 1 NC_003155.4 PF00058: Low-density lipoprotein receptor repeat class B; hypothetical protein 868694 1212404 SAV_715 Streptomyces avermitilis MA-4680 hypothetical protein NP_821890.1 867789 R 227882 CDS NP_821891.1 29827257 1210082 complement(868691..869677) 1 NC_003155.4 PF02737: 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; 3-hydroxyacyl-CoA dehydrogenase 869677 fadC6 1210082 fadC6 Streptomyces avermitilis MA-4680 3-hydroxyacyl-CoA dehydrogenase NP_821891.1 868691 R 227882 CDS NP_821892.1 29827258 1210083 complement(869743..870525) 1 NC_003155.4 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 870525 echA3 1210083 echA3 Streptomyces avermitilis MA-4680 enoyl-CoA hydratase NP_821892.1 869743 R 227882 CDS NP_821893.1 29827259 1212405 complement(870522..871754) 1 NC_003155.4 fatty acid-CoA racemase 871754 1212405 SAV_718 Streptomyces avermitilis MA-4680 fatty acid-CoA racemase NP_821893.1 870522 R 227882 CDS NP_821894.1 29827260 1210084 complement(871760..873001) 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; glutaryl-CoA dehydrogenase 873001 gcdH1 1210084 gcdH1 Streptomyces avermitilis MA-4680 glutaryl-CoA dehydrogenase NP_821894.1 871760 R 227882 CDS NP_821895.1 29827261 1212406 873180..873584 1 NC_003155.4 truncated; transposase 873584 1212406 SAV_720 Streptomyces avermitilis MA-4680 transposase NP_821895.1 873180 D 227882 CDS NP_821896.1 29827262 1212407 complement(873611..873907) 1 NC_003155.4 hydrolase 873907 1212407 SAV_721 Streptomyces avermitilis MA-4680 hydrolase NP_821896.1 873611 R 227882 CDS NP_821897.1 29827263 1212408 875568..875810 1 NC_003155.4 truncated; AraC family transcription regulator 875810 1212408 SAV_722 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_821897.1 875568 D 227882 CDS NP_821898.1 29827264 1212409 875850..876020 1 NC_003155.4 hypothetical protein 876020 1212409 SAV_723 Streptomyces avermitilis MA-4680 hypothetical protein NP_821898.1 875850 D 227882 CDS NP_821899.1 29827265 1212410 876545..877597 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 877597 1212410 SAV_724 Streptomyces avermitilis MA-4680 dehydrogenase NP_821899.1 876545 D 227882 CDS NP_821900.1 29827266 1212411 complement(877599..878420) 1 NC_003155.4 hypothetical protein 878420 1212411 SAV_725 Streptomyces avermitilis MA-4680 hypothetical protein NP_821900.1 877599 R 227882 CDS NP_821901.1 29827267 1212412 complement(878482..879468) 1 NC_003155.4 oxidoreductase 879468 1212412 SAV_726 Streptomyces avermitilis MA-4680 oxidoreductase NP_821901.1 878482 R 227882 CDS NP_821902.1 29827268 1212413 complement(880629..881234) 1 NC_003155.4 hypothetical protein 881234 1212413 SAV_727 Streptomyces avermitilis MA-4680 hypothetical protein NP_821902.1 880629 R 227882 CDS NP_821903.1 29827269 1212414 complement(881179..881442) 1 NC_003155.4 hypothetical protein 881442 1212414 SAV_728 Streptomyces avermitilis MA-4680 hypothetical protein NP_821903.1 881179 R 227882 CDS NP_821904.1 29827270 1212415 complement(881547..882500) 1 NC_003155.4 LysR family transcriptional regulator 882500 1212415 SAV_729 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_821904.1 881547 R 227882 CDS NP_821905.1 29827271 1212416 882605..883498 1 NC_003155.4 PF01073: 3-beta hydroxysteroid dehydrogenase/isomerase family; hypothetical protein 883498 1212416 SAV_730 Streptomyces avermitilis MA-4680 hypothetical protein NP_821905.1 882605 D 227882 CDS NP_821906.1 29827272 1212417 883572..883937 1 NC_003155.4 hypothetical protein 883937 1212417 SAV_731 Streptomyces avermitilis MA-4680 hypothetical protein NP_821906.1 883572 D 227882 CDS NP_821907.1 29827273 1212418 884059..884292 1 NC_003155.4 hypothetical protein 884292 1212418 SAV_732 Streptomyces avermitilis MA-4680 hypothetical protein NP_821907.1 884059 D 227882 CDS NP_821908.1 29827274 1212419 complement(884559..885191) 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein 885191 1212419 SAV_733 Streptomyces avermitilis MA-4680 hypothetical protein NP_821908.1 884559 R 227882 CDS NP_821909.1 29827275 1212420 885591..887036 1 NC_003155.4 PF03572: Peptidase family S41B; protease 887036 1212420 SAV_734 Streptomyces avermitilis MA-4680 protease NP_821909.1 885591 D 227882 CDS NP_821910.1 29827276 1212421 887118..887300 1 NC_003155.4 hypothetical protein 887300 1212421 SAV_735 Streptomyces avermitilis MA-4680 hypothetical protein NP_821910.1 887118 D 227882 CDS NP_821911.1 29827277 1212422 887475..887681 1 NC_003155.4 PF00126: Bacterial regulatory helix-turn-helix protein, lysR family; transcriptional regulator 887681 1212422 SAV_736 Streptomyces avermitilis MA-4680 transcriptional regulator NP_821911.1 887475 D 227882 CDS NP_821912.1 29827278 1212423 complement(887698..888492) 1 NC_003155.4 PF00702: haloacid dehalogenase-like hydrolase; 2-haloalkanoic acid dehalogenase 888492 1212423 SAV_737 Streptomyces avermitilis MA-4680 2-haloalkanoic acid dehalogenase NP_821912.1 887698 R 227882 CDS NP_821913.1 29827279 1212424 complement(888636..888812) 1 NC_003155.4 PF05532: CsbD-like; hypothetical protein 888812 1212424 SAV_738 Streptomyces avermitilis MA-4680 hypothetical protein NP_821913.1 888636 R 227882 CDS NP_821914.1 29827280 1212425 888992..889162 1 NC_003155.4 hypothetical protein 889162 1212425 SAV_739 Streptomyces avermitilis MA-4680 hypothetical protein NP_821914.1 888992 D 227882 CDS NP_821915.1 29827281 1212426 889498..889851 1 NC_003155.4 PF05239: PRC-barrel domain; hypothetical protein 889851 1212426 SAV_740 Streptomyces avermitilis MA-4680 hypothetical protein NP_821915.1 889498 D 227882 CDS NP_821916.1 29827282 1210085 890067..890906 1 NC_003155.4 RNA polymerase alternative sigma factor; RNA polymerase sigma factor 890906 sig8 1210085 sig8 Streptomyces avermitilis MA-4680 RNA polymerase sigma factor NP_821916.1 890067 D 227882 CDS NP_821917.1 29827283 1212427 891284..892279 1 NC_003155.4 PF00165: Bacterial regulatory helix-turn-helix proteins, araC family; AraC family transcription regulator 892279 1212427 SAV_742 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_821917.1 891284 D 227882 CDS NP_821918.1 29827284 1212428 892951..893352 1 NC_003155.4 PF03995: Peptidase inhibitor family I36; peptidase inhibitor 893352 1212428 SAV_743 Streptomyces avermitilis MA-4680 peptidase inhibitor NP_821918.1 892951 D 227882 CDS NP_821919.1 29827285 1212429 complement(893346..893903) 1 NC_003155.4 IS630 family transposase 893903 1212429 SAV_744 Streptomyces avermitilis MA-4680 IS630 family transposase NP_821919.1 893346 R 227882 CDS NP_821920.1 29827286 1212430 complement(893900..894439) 1 NC_003155.4 IS630 family transposase 894439 1212430 SAV_745 Streptomyces avermitilis MA-4680 IS630 family transposase NP_821920.1 893900 R 227882 CDS NP_821921.1 29827287 1212431 894729..895703 1 NC_003155.4 hypothetical protein 895703 1212431 SAV_746 Streptomyces avermitilis MA-4680 hypothetical protein NP_821921.1 894729 D 227882 CDS NP_821922.1 29827288 1212432 896150..897283 1 NC_003155.4 hypothetical protein 897283 1212432 SAV_747 Streptomyces avermitilis MA-4680 hypothetical protein NP_821922.1 896150 D 227882 CDS NP_821923.1 29827289 1212433 897643..899004 1 NC_003155.4 hypothetical protein 899004 1212433 SAV_748 Streptomyces avermitilis MA-4680 hypothetical protein NP_821923.1 897643 D 227882 CDS NP_821924.1 29827290 1212434 complement(899196..899828) 1 NC_003155.4 methyltransferase 899828 1212434 SAV_749 Streptomyces avermitilis MA-4680 methyltransferase NP_821924.1 899196 R 227882 CDS NP_821925.1 29827291 1212435 900012..900425 1 NC_003155.4 TetR family transcriptional regulator 900425 1212435 SAV_750 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_821925.1 900012 D 227882 CDS NP_821926.1 29827292 1212436 901504..902592 1 NC_003155.4 ATP-dependent carboxylate-amine ligase; carboxylate-amine ligase 902592 1212436 SAV_751 Streptomyces avermitilis MA-4680 carboxylate-amine ligase NP_821926.1 901504 D 227882 CDS NP_821927.1 29827293 1212437 complement(903011..903400) 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein 903400 1212437 SAV_752 Streptomyces avermitilis MA-4680 hypothetical protein NP_821927.1 903011 R 227882 CDS NP_821928.1 29827294 1212438 complement(903457..903648) 1 NC_003155.4 hypothetical protein 903648 1212438 SAV_753 Streptomyces avermitilis MA-4680 hypothetical protein NP_821928.1 903457 R 227882 CDS NP_821929.1 29827295 1212439 903755..904408 1 NC_003155.4 TetR family transcriptional regulator 904408 1212439 SAV_754 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_821929.1 903755 D 227882 CDS NP_821930.1 29827296 1212440 904587..905627 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 905627 1212440 SAV_755 Streptomyces avermitilis MA-4680 dehydrogenase NP_821930.1 904587 D 227882 CDS NP_821931.1 29827297 1212441 complement(906101..908071) 1 NC_003155.4 hypothetical protein 908071 1212441 SAV_756 Streptomyces avermitilis MA-4680 hypothetical protein NP_821931.1 906101 R 227882 CDS NP_821932.1 29827298 1212442 909086..910072 1 NC_003155.4 PF03734: ErfK/YbiS/YcfS/YnhG; hypothetical protein 910072 1212442 SAV_757 Streptomyces avermitilis MA-4680 hypothetical protein NP_821932.1 909086 D 227882 CDS NP_821933.1 29827299 1212443 complement(910889..911494) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 911494 1212443 SAV_758 Streptomyces avermitilis MA-4680 acetyltransferase NP_821933.1 910889 R 227882 CDS NP_821934.1 29827300 1212444 911580..912161 1 NC_003155.4 hypothetical protein 912161 1212444 SAV_759 Streptomyces avermitilis MA-4680 hypothetical protein NP_821934.1 911580 D 227882 CDS NP_821935.1 29827301 1212445 complement(912097..912768) 1 NC_003155.4 PF00394: Multicopper oxidase; multicopper oxidase 912768 1212445 SAV_760 Streptomyces avermitilis MA-4680 multicopper oxidase NP_821935.1 912097 R 227882 CDS NP_821936.1 29827302 1212446 complement(912621..912968) 1 NC_003155.4 hypothetical protein 912968 1212446 SAV_761 Streptomyces avermitilis MA-4680 hypothetical protein NP_821936.1 912621 R 227882 CDS NP_821937.1 29827303 1212447 913425..914252 1 NC_003155.4 methyltransferase 914252 1212447 SAV_762 Streptomyces avermitilis MA-4680 methyltransferase NP_821937.1 913425 D 227882 CDS NP_821938.1 29827304 1212448 complement(914353..914658) 1 NC_003155.4 hypothetical protein 914658 1212448 SAV_763 Streptomyces avermitilis MA-4680 hypothetical protein NP_821938.1 914353 R 227882 CDS NP_821939.1 29827305 1212449 complement(914734..915531) 1 NC_003155.4 hypothetical protein 915531 1212449 SAV_764 Streptomyces avermitilis MA-4680 hypothetical protein NP_821939.1 914734 R 227882 CDS NP_821940.1 29827306 1212450 complement(915541..915750) 1 NC_003155.4 hypothetical protein 915750 1212450 SAV_765 Streptomyces avermitilis MA-4680 hypothetical protein NP_821940.1 915541 R 227882 CDS NP_821941.1 29827307 1212451 915952..916188 1 NC_003155.4 hypothetical protein 916188 1212451 SAV_766 Streptomyces avermitilis MA-4680 hypothetical protein NP_821941.1 915952 D 227882 CDS NP_821942.1 29827308 1212452 complement(916344..918416) 1 NC_003155.4 PF00989: PAS domain, PF01590: GAF domain; magnesium or manganese-dependent protein phosphatase 918416 prpJ2 1212452 prpJ2 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_821942.1 916344 R 227882 CDS NP_821943.1 29827309 1212453 918676..919065 1 NC_003155.4 hypothetical protein 919065 1212453 SAV_768 Streptomyces avermitilis MA-4680 hypothetical protein NP_821943.1 918676 D 227882 CDS NP_821944.1 29827310 1212454 complement(919505..919888) 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein 919888 1212454 SAV_769 Streptomyces avermitilis MA-4680 hypothetical protein NP_821944.1 919505 R 227882 CDS NP_821945.1 29827311 1212455 complement(920542..921387) 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 921387 1212455 SAV_770 Streptomyces avermitilis MA-4680 dehydrogenase NP_821945.1 920542 R 227882 CDS NP_821946.1 29827312 1212456 921494..922408 1 NC_003155.4 LysR family transcriptional regulator 922408 1212456 SAV_771 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_821946.1 921494 D 227882 CDS NP_821947.1 29827313 1212457 complement(922521..922928) 1 NC_003155.4 GntR family transcriptional regulator 922928 1212457 SAV_772 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_821947.1 922521 R 227882 CDS NP_821948.1 29827314 1212458 complement(922853..923590) 1 NC_003155.4 hypothetical protein 923590 1212458 SAV_773 Streptomyces avermitilis MA-4680 hypothetical protein NP_821948.1 922853 R 227882 CDS NP_821949.1 29827315 1212459 complement(923778..925370) 1 NC_003155.4 PF01360: Monooxygenase; monooxygenase 925370 1212459 SAV_774 Streptomyces avermitilis MA-4680 monooxygenase NP_821949.1 923778 R 227882 CDS NP_821950.1 29827316 1212460 925541..926167 1 NC_003155.4 similar to actII-1; TetR family transcriptional regulator 926167 1212460 SAV_775 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_821950.1 925541 D 227882 CDS NP_821951.1 29827317 1212461 complement(926268..926516) 1 NC_003155.4 hypothetical protein 926516 1212461 SAV_776 Streptomyces avermitilis MA-4680 hypothetical protein NP_821951.1 926268 R 227882 CDS NP_821952.1 29827318 1212462 complement(926586..927077) 1 NC_003155.4 hypothetical protein 927077 1212462 SAV_777 Streptomyces avermitilis MA-4680 hypothetical protein NP_821952.1 926586 R 227882 CDS NP_821953.1 29827319 1212463 927524..928555 1 NC_003155.4 PF00657: GDSL-like Lipase/Acylhydrolase; hypothetical protein 928555 1212463 SAV_778 Streptomyces avermitilis MA-4680 hypothetical protein NP_821953.1 927524 D 227882 CDS NP_821954.1 29827320 1212464 928799..928972 1 NC_003155.4 transposase 928972 1212464 SAV_779 Streptomyces avermitilis MA-4680 transposase NP_821954.1 928799 D 227882 CDS NP_821955.1 29827321 1212465 complement(929152..930075) 1 NC_003155.4 PF00296: Luciferase-like monooxygenase; monooxygenase 930075 1212465 SAV_780 Streptomyces avermitilis MA-4680 monooxygenase NP_821955.1 929152 R 227882 CDS NP_821956.1 29827322 1212466 930473..930895 1 NC_003155.4 hypothetical protein 930895 1212466 SAV_781 Streptomyces avermitilis MA-4680 hypothetical protein NP_821956.1 930473 D 227882 CDS NP_821957.1 29827323 1212467 complement(930904..931179) 1 NC_003155.4 hypothetical protein 931179 1212467 SAV_782 Streptomyces avermitilis MA-4680 hypothetical protein NP_821957.1 930904 R 227882 CDS NP_821958.1 29827324 1212468 931759..932133 1 NC_003155.4 hypothetical protein 932133 1212468 SAV_783 Streptomyces avermitilis MA-4680 hypothetical protein NP_821958.1 931759 D 227882 CDS NP_821959.1 29827325 1212469 932225..932773 1 NC_003155.4 hypothetical protein 932773 1212469 SAV_784 Streptomyces avermitilis MA-4680 hypothetical protein NP_821959.1 932225 D 227882 CDS NP_821960.1 29827326 1212470 complement(934229..934714) 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein 934714 1212470 SAV_785 Streptomyces avermitilis MA-4680 hypothetical protein NP_821960.1 934229 R 227882 CDS NP_821961.1 29827327 1212471 complement(935953..938727) 1 NC_003155.4 PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; membrane protein; magnesium or manganese-dependent protein phosphatase 938727 prpJ3 1212471 prpJ3 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_821961.1 935953 R 227882 CDS NP_821962.1 29827328 1212472 complement(939117..939773) 1 NC_003155.4 weak similarity to chloramphenicol phosphotransferase; hypothetical protein 939773 1212472 SAV_787 Streptomyces avermitilis MA-4680 hypothetical protein NP_821962.1 939117 R 227882 CDS NP_821963.1 29827329 1212473 complement(940165..940638) 1 NC_003155.4 PF02627: Carboxymuconolactone decarboxylase family; hypothetical protein 940638 1212473 SAV_788 Streptomyces avermitilis MA-4680 hypothetical protein NP_821963.1 940165 R 227882 CDS NP_821964.1 29827330 1212474 complement(940910..942349) 1 NC_003155.4 PF00171: Aldehyde dehydrogenase family; aldehyde dehydrogenase 942349 1212474 SAV_789 Streptomyces avermitilis MA-4680 aldehyde dehydrogenase NP_821964.1 940910 R 227882 CDS NP_821965.1 29827331 1212475 complement(942366..942767) 1 NC_003155.4 hypothetical protein 942767 1212475 SAV_790 Streptomyces avermitilis MA-4680 hypothetical protein NP_821965.1 942366 R 227882 CDS NP_821966.1 29827332 1212476 complement(942846..944381) 1 NC_003155.4 PF02133: Permease for cytosine/purines, uracil, thiamine, allantoin; transmembrane transport protein 944381 1212476 SAV_791 Streptomyces avermitilis MA-4680 transmembrane transport protein NP_821966.1 942846 R 227882 CDS NP_821967.1 29827333 1212477 944545..945936 1 NC_003155.4 transcriptional regulator 945936 1212477 SAV_792 Streptomyces avermitilis MA-4680 transcriptional regulator NP_821967.1 944545 D 227882 CDS NP_821968.1 29827334 1212478 946221..946775 1 NC_003155.4 PF07681: DoxX; hypothetical protein 946775 1212478 SAV_793 Streptomyces avermitilis MA-4680 hypothetical protein NP_821968.1 946221 D 227882 CDS NP_821969.1 29827335 1212479 947036..948439 1 NC_003155.4 amino acid permease; ABC transporter permease 948439 1212479 SAV_794 Streptomyces avermitilis MA-4680 ABC transporter permease NP_821969.1 947036 D 227882 CDS NP_821970.1 29827336 1212480 complement(948548..949270) 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein 949270 1212480 SAV_795 Streptomyces avermitilis MA-4680 hypothetical protein NP_821970.1 948548 R 227882 CDS NP_821971.1 29827337 1212481 complement(949418..950035) 1 NC_003155.4 hypothetical protein 950035 1212481 SAV_796 Streptomyces avermitilis MA-4680 hypothetical protein NP_821971.1 949418 R 227882 CDS NP_821972.1 29827338 1212482 complement(950601..950984) 1 NC_003155.4 hypothetical protein 950984 1212482 SAV_797 Streptomyces avermitilis MA-4680 hypothetical protein NP_821972.1 950601 R 227882 CDS NP_821973.1 29827339 1212483 complement(950995..951585) 1 NC_003155.4 hypothetical protein 951585 1212483 SAV_798 Streptomyces avermitilis MA-4680 hypothetical protein NP_821973.1 950995 R 227882 CDS NP_821974.1 29827340 1212484 complement(951567..951881) 1 NC_003155.4 hypothetical protein 951881 1212484 SAV_799 Streptomyces avermitilis MA-4680 hypothetical protein NP_821974.1 951567 R 227882 CDS NP_821975.1 29827341 1212485 951882..952160 1 NC_003155.4 hypothetical protein 952160 1212485 SAV_800 Streptomyces avermitilis MA-4680 hypothetical protein NP_821975.1 951882 D 227882 CDS NP_821976.1 29827342 1210086 952657..954111 1 NC_003155.4 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 954111 argG1 1210086 argG1 Streptomyces avermitilis MA-4680 argininosuccinate synthase NP_821976.1 952657 D 227882 CDS NP_821977.1 29827343 1212486 954464..955318 1 NC_003155.4 hypothetical protein 955318 1212486 SAV_802 Streptomyces avermitilis MA-4680 hypothetical protein NP_821977.1 954464 D 227882 CDS NP_821978.1 29827344 1210087 complement(955607..957277) 1 NC_003155.4 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 957277 pgmA 1210087 pgmA Streptomyces avermitilis MA-4680 phosphoglucomutase NP_821978.1 955607 R 227882 CDS NP_821979.1 29827345 1212487 complement(957808..958059) 1 NC_003155.4 hypothetical protein 958059 1212487 SAV_804 Streptomyces avermitilis MA-4680 hypothetical protein NP_821979.1 957808 R 227882 CDS NP_821980.1 29827346 1212488 complement(958134..958262) 1 NC_003155.4 hypothetical protein 958262 1212488 SAV_805 Streptomyces avermitilis MA-4680 hypothetical protein NP_821980.1 958134 R 227882 CDS NP_821981.1 29827347 1212489 958610..960352 1 NC_003155.4 PF00515: TRP domain; hypothetical protein 960352 1212489 SAV_806 Streptomyces avermitilis MA-4680 hypothetical protein NP_821981.1 958610 D 227882 CDS NP_821982.1 29827348 1212490 960571..960810 1 NC_003155.4 hypothetical protein 960810 1212490 SAV_807 Streptomyces avermitilis MA-4680 hypothetical protein NP_821982.1 960571 D 227882 CDS NP_821983.1 29827349 1212491 complement(961036..962355) 1 NC_003155.4 PF00989: PAS domain; magnesium or manganese-dependent protein phosphatase 962355 prpC2 1212491 prpC2 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_821983.1 961036 R 227882 CDS NP_821984.1 29827350 1210088 complement(962573..963100) 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 963100 sig9 1210088 sig9 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_821984.1 962573 R 227882 CDS NP_821985.1 29827351 1212492 complement(963156..964286) 1 NC_003155.4 PF00070: Pyridine nucleotide-disulphide oxidoreductase; dehydrogenase 964286 1212492 SAV_810 Streptomyces avermitilis MA-4680 dehydrogenase NP_821985.1 963156 R 227882 CDS NP_821986.1 29827352 1212493 complement(964283..964678) 1 NC_003155.4 hypothetical protein 964678 1212493 SAV_811 Streptomyces avermitilis MA-4680 hypothetical protein NP_821986.1 964283 R 227882 CDS NP_821987.1 29827353 1212494 complement(964891..965100) 1 NC_003155.4 small hydrophilic protein 965100 1212494 SAV_812 Streptomyces avermitilis MA-4680 small hydrophilic protein NP_821987.1 964891 R 227882 CDS NP_821988.1 29827354 1212495 complement(965305..965661) 1 NC_003155.4 PF05239: PRC-barrel domain; hypothetical protein 965661 1212495 SAV_813 Streptomyces avermitilis MA-4680 hypothetical protein NP_821988.1 965305 R 227882 CDS NP_821989.1 29827355 1212496 complement(966143..966421) 1 NC_003155.4 hypothetical protein 966421 1212496 SAV_814 Streptomyces avermitilis MA-4680 hypothetical protein NP_821989.1 966143 R 227882 CDS NP_821990.1 29827356 1212497 967134..967313 1 NC_003155.4 hypothetical protein 967313 1212497 SAV_815 Streptomyces avermitilis MA-4680 hypothetical protein NP_821990.1 967134 D 227882 CDS NP_821991.1 29827357 1212498 967424..967597 1 NC_003155.4 PF05532: CsbD-like; hypothetical protein 967597 1212498 SAV_816 Streptomyces avermitilis MA-4680 hypothetical protein NP_821991.1 967424 D 227882 CDS NP_821992.1 29827358 1212499 complement(968219..968503) 1 NC_003155.4 hypothetical protein 968503 1212499 SAV_817 Streptomyces avermitilis MA-4680 hypothetical protein NP_821992.1 968219 R 227882 CDS NP_821993.1 29827359 1212500 968939..970015 1 NC_003155.4 hypothetical protein 970015 1212500 SAV_818 Streptomyces avermitilis MA-4680 hypothetical protein NP_821993.1 968939 D 227882 CDS NP_821994.1 29827360 1212501 970221..971444 1 NC_003155.4 lipase 971444 1212501 SAV_819 Streptomyces avermitilis MA-4680 lipase NP_821994.1 970221 D 227882 CDS NP_821995.1 29827361 1212502 complement(971806..972096) 1 NC_003155.4 hypothetical protein 972096 1212502 SAV_820 Streptomyces avermitilis MA-4680 hypothetical protein NP_821995.1 971806 R 227882 CDS NP_821996.1 29827362 1212503 complement(972201..972629) 1 NC_003155.4 IS200/IS605 family; IS200-like transposase 972629 1212503 SAV_821 Streptomyces avermitilis MA-4680 IS200-like transposase NP_821996.1 972201 R 227882 CDS NP_821997.1 29827363 1212504 972680..973894 1 NC_003155.4 IS200/IS605 family; IS200-like transposase 973894 1212504 SAV_822 Streptomyces avermitilis MA-4680 IS200-like transposase NP_821997.1 972680 D 227882 CDS NP_821998.1 29827364 1212505 complement(974221..974766) 1 NC_003155.4 hypothetical protein 974766 1212505 SAV_823 Streptomyces avermitilis MA-4680 hypothetical protein NP_821998.1 974221 R 227882 CDS NP_821999.1 29827365 1212506 975546..975818 1 NC_003155.4 hypothetical protein 975818 1212506 SAV_824 Streptomyces avermitilis MA-4680 hypothetical protein NP_821999.1 975546 D 227882 CDS NP_822000.1 29827366 1210089 complement(976138..977037) 1 NC_003155.4 aminoglycoside phosphotransferase 977037 aph1 1210089 aph1 Streptomyces avermitilis MA-4680 aminoglycoside phosphotransferase NP_822000.1 976138 R 227882 CDS NP_822001.1 29827367 1210090 complement(977461..977664) 1 NC_003155.4 cold shock protein 977664 cspD1 1210090 cspD1 Streptomyces avermitilis MA-4680 cold shock protein NP_822001.1 977461 R 227882 CDS NP_822002.1 29827368 1210091 978292..979311 1 NC_003155.4 3-oxoacyl-ACP synthase III 979311 fabH6 1210091 fabH6 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP synthase III NP_822002.1 978292 D 227882 CDS NP_822003.1 29827369 1212507 complement(979582..982674) 1 NC_003155.4 PF05592: Bacterial alpha-L-rhamnosidase; rhamnosidase 982674 1212507 SAV_828 Streptomyces avermitilis MA-4680 rhamnosidase NP_822003.1 979582 R 227882 CDS NP_822004.1 29827370 1212508 complement(983146..983523) 1 NC_003155.4 hypothetical protein 983523 1212508 SAV_829 Streptomyces avermitilis MA-4680 hypothetical protein NP_822004.1 983146 R 227882 CDS NP_822005.1 29827371 1212509 complement(983523..983747) 1 NC_003155.4 hypothetical protein 983747 1212509 SAV_830 Streptomyces avermitilis MA-4680 hypothetical protein NP_822005.1 983523 R 227882 CDS NP_822006.1 29827372 1212510 complement(983914..984960) 1 NC_003155.4 LacI family transcriptional regulator 984960 1212510 SAV_831 Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_822006.1 983914 R 227882 CDS NP_822007.1 29827373 1212511 complement(984957..985991) 1 NC_003155.4 GFO/IDH/MOCA-family protein 985991 1212511 SAV_832 Streptomyces avermitilis MA-4680 GFO/IDH/MOCA-family protein NP_822007.1 984957 R 227882 CDS NP_822008.1 29827374 1212512 complement(985988..986839) 1 NC_003155.4 PF00702: haloacid dehalogenase-like hydrolase; hydrolase 986839 1212512 SAV_833 Streptomyces avermitilis MA-4680 hydrolase NP_822008.1 985988 R 227882 CDS NP_822009.1 29827375 1212513 complement(986811..988160) 1 NC_003155.4 sensory transduction pleiotropic regulatory protein 988160 1212513 SAV_834 Streptomyces avermitilis MA-4680 sensory transduction pleiotropic regulatory protein NP_822009.1 986811 R 227882 CDS NP_822010.1 29827376 1212514 complement(988169..989314) 1 NC_003155.4 glycosyltransferase 989314 1212514 SAV_835 Streptomyces avermitilis MA-4680 glycosyltransferase NP_822010.1 988169 R 227882 CDS NP_822011.1 29827377 1212515 complement(989357..990832) 1 NC_003155.4 PF01554: MatE; efflux family protein 990832 matE 1212515 matE Streptomyces avermitilis MA-4680 efflux family protein NP_822011.1 989357 R 227882 CDS NP_822012.1 29827378 1212516 complement(991134..991487) 1 NC_003155.4 NADH:FMN oxidoreductase 991487 1212516 SAV_837 Streptomyces avermitilis MA-4680 NADH:FMN oxidoreductase NP_822012.1 991134 R 227882 CDS NP_822013.1 29827379 1210092 complement(991484..992719) 1 NC_003155.4 CYP178A1, nrps7 gene cluster; cytochrome P450 992719 cyp4 1210092 cyp4 Streptomyces avermitilis MA-4680 cytochrome P450 NP_822013.1 991484 R 227882 CDS NP_822014.1 29827380 1212517 complement(992728..994536) 1 NC_003155.4 nrps7 gene cluster; non-ribosomal peptide synthetase 994536 nrps7-1 1212517 nrps7-1 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_822014.1 992728 R 227882 CDS NP_822015.1 29827381 1212518 complement(994545..995348) 1 NC_003155.4 nrps7 gene cluster; thioesterase 995348 1212518 SAV_840 Streptomyces avermitilis MA-4680 thioesterase NP_822015.1 994545 R 227882 CDS NP_822016.1 29827382 1212519 complement(995480..996217) 1 NC_003155.4 nrps7 gene cluster; ThiG-like protein 996217 1212519 SAV_841 Streptomyces avermitilis MA-4680 ThiG-like protein NP_822016.1 995480 R 227882 CDS NP_822017.1 29827383 1212520 complement(996214..997125) 1 NC_003155.4 nrps7 gene cluster; branched-chain amino acid aminotransferase 997125 1212520 SAV_842 Streptomyces avermitilis MA-4680 branched-chain amino acid aminotransferase NP_822017.1 996214 R 227882 CDS NP_822018.1 29827384 1212521 complement(997152..997847) 1 NC_003155.4 nrps7 gene cluster; thioesterase 997847 1212521 SAV_843 Streptomyces avermitilis MA-4680 thioesterase NP_822018.1 997152 R 227882 CDS NP_822019.1 29827385 1212522 complement(997877..999166) 1 NC_003155.4 nrps7 gene cluster; non-ribosomal peptide synthetase 999166 nrps7-2 1212522 nrps7-2 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_822019.1 997877 R 227882 CDS NP_822020.1 29827386 1212523 complement(999163..1002321) 1 NC_003155.4 nrps7 gene cluster; modular polyketide synthase 1002321 1212523 SAV_845 Streptomyces avermitilis MA-4680 modular polyketide synthase NP_822020.1 999163 R 227882 CDS NP_822021.1 29827387 1212524 complement(1002287..1004011) 1 NC_003155.4 nrps7 gene cluster; non-ribosomal peptide synthetase 1004011 nrps7-3 1212524 nrps7-3 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_822021.1 1002287 R 227882 CDS NP_822022.1 29827388 1212525 complement(1004016..1007462) 1 NC_003155.4 nrps7 gene cluster; non-ribosomal peptide synthetase 1007462 nrps7-4 1212525 nrps7-4 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_822022.1 1004016 R 227882 CDS NP_822023.1 29827389 1212526 complement(1007459..1009384) 1 NC_003155.4 nrps7 gene cluster; non-ribosomal peptide synthetase 1009384 nrps7-5 1212526 nrps7-5 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_822023.1 1007459 R 227882 CDS NP_822024.1 29827390 1212527 complement(1009432..1011063) 1 NC_003155.4 nrps7 gene cluster; methyltransferase 1011063 1212527 SAV_849 Streptomyces avermitilis MA-4680 methyltransferase NP_822024.1 1009432 R 227882 CDS NP_822025.1 29827391 1212528 1012883..1013704 1 NC_003155.4 nrps7 gene cluster; hypothetical protein 1013704 1212528 SAV_850 Streptomyces avermitilis MA-4680 hypothetical protein NP_822025.1 1012883 D 227882 CDS NP_822026.1 29827392 1212529 complement(1013750..1013968) 1 NC_003155.4 nrps7 gene cluster; MbtH-like protein 1013968 1212529 SAV_851 Streptomyces avermitilis MA-4680 MbtH-like protein NP_822026.1 1013750 R 227882 CDS NP_822027.1 29827393 1212530 complement(1014084..1015736) 1 NC_003155.4 nrps7 gene cluster; non-ribosomal peptide synthetase 1015736 nrps7-6 1212530 nrps7-6 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_822027.1 1014084 R 227882 CDS NP_822028.1 29827394 1212531 complement(1015739..1017331) 1 NC_003155.4 nrps7 gene cluster; non-ribosomal peptide synthetase 1017331 nrps7-7 1212531 nrps7-7 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_822028.1 1015739 R 227882 CDS NP_822029.1 29827395 1212532 complement(1017328..1019550) 1 NC_003155.4 nrps7 gene cluster; amidase 1019550 1212532 SAV_854 Streptomyces avermitilis MA-4680 amidase NP_822029.1 1017328 R 227882 CDS NP_822030.1 29827396 1212533 complement(1019547..1021202) 1 NC_003155.4 nrps7 gene cluster; non-ribosomal peptide synthetase 1021202 nrps7-8 1212533 nrps7-8 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_822030.1 1019547 R 227882 CDS NP_822031.1 29827397 1212534 complement(1021234..1022031) 1 NC_003155.4 nrps7 gene cluster; thioesterase 1022031 1212534 SAV_856 Streptomyces avermitilis MA-4680 thioesterase NP_822031.1 1021234 R 227882 CDS NP_822032.1 29827398 1212535 1023063..1024484 1 NC_003155.4 nrps7 gene cluster; non-ribosomal peptide synthetase 1024484 nrps7-9 1212535 nrps7-9 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_822032.1 1023063 D 227882 CDS NP_822033.1 29827399 1212536 1024676..1024900 1 NC_003155.4 nrps7 gene cluster; hypothetical protein 1024900 1212536 SAV_858 Streptomyces avermitilis MA-4680 hypothetical protein NP_822033.1 1024676 D 227882 CDS NP_822034.1 29827400 1212537 1025128..1026513 1 NC_003155.4 nrps7 gene cluster; non-ribosomal peptide synthetase 1026513 nrps7-10 1212537 nrps7-10 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_822034.1 1025128 D 227882 CDS NP_822035.1 29827401 1212538 1026551..1028176 1 NC_003155.4 nrps7 gene cluster; non-ribosomal peptide synthetase 1028176 nrps7-11 1212538 nrps7-11 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_822035.1 1026551 D 227882 CDS NP_822036.1 29827402 1212539 1028236..1029129 1 NC_003155.4 nrps7 gene cluster; reductase 1029129 1212539 SAV_861 Streptomyces avermitilis MA-4680 reductase NP_822036.1 1028236 D 227882 CDS NP_822037.1 29827403 1212540 complement(1029133..1031103) 1 NC_003155.4 nrps7 gene cluster; hypothetical protein 1031103 1212540 SAV_862 Streptomyces avermitilis MA-4680 hypothetical protein NP_822037.1 1029133 R 227882 CDS NP_822038.1 29827404 1212541 complement(1031106..1032413) 1 NC_003155.4 Catalyzes the formation of malnoyl-CoA, which in turn controls the rate of fatty acid metabolism; hypothetical protein 1032413 1212541 SAV_863 Streptomyces avermitilis MA-4680 hypothetical protein NP_822038.1 1031106 R 227882 CDS NP_822039.1 29827405 1212542 complement(1032421..1032669) 1 NC_003155.4 nrps7 gene cluster; peptide carrier protein 1032669 1212542 SAV_864 Streptomyces avermitilis MA-4680 peptide carrier protein NP_822039.1 1032421 R 227882 CDS NP_822040.1 29827406 1212543 complement(1032666..1035416) 1 NC_003155.4 nrps7 gene cluster; non-ribosomal peptide synthetase 1035416 nrps7-12 1212543 nrps7-12 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_822040.1 1032666 R 227882 CDS NP_822041.1 29827407 1212544 complement(1035525..1035992) 1 NC_003155.4 nrps7 gene cluster; hypothetical protein 1035992 1212544 SAV_866 Streptomyces avermitilis MA-4680 hypothetical protein NP_822041.1 1035525 R 227882 CDS NP_822042.1 29827408 1212545 1036695..1038659 1 NC_003155.4 nrps7 gene cluster; ABC transporter ATP-binding protein 1038659 1212545 SAV_867 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_822042.1 1036695 D 227882 CDS NP_822043.1 29827409 1212546 1038659..1040461 1 NC_003155.4 nrps7 gene cluster; ABC transporter ATP-binding protein 1040461 1212546 SAV_868 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_822043.1 1038659 D 227882 CDS NP_822044.1 29827410 1212547 1040665..1042269 1 NC_003155.4 nrps7 gene cluster; non-ribosomal peptide synthetase 1042269 nrps7-13 1212547 nrps7-13 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_822044.1 1040665 D 227882 CDS NP_822045.1 29827411 1212548 1042274..1042495 1 NC_003155.4 hypothetical protein 1042495 1212548 SAV_870 Streptomyces avermitilis MA-4680 hypothetical protein NP_822045.1 1042274 D 227882 CDS NP_822046.1 29827412 1212549 1042499..1043434 1 NC_003155.4 PF05721: Phytanoyl-CoA dioxygenase (PhyH); dioxygenase 1043434 1212549 SAV_871 Streptomyces avermitilis MA-4680 dioxygenase NP_822046.1 1042499 D 227882 CDS NP_822047.1 29827413 1212550 1043718..1044683 1 NC_003155.4 PF00248: Aldo/keto reductase family; oxidoreductase 1044683 1212550 SAV_872 Streptomyces avermitilis MA-4680 oxidoreductase NP_822047.1 1043718 D 227882 CDS NP_822048.1 29827414 1212551 complement(1044960..1045295) 1 NC_003155.4 PF03621: MbtH-like protein; hypothetical protein 1045295 1212551 SAV_873 Streptomyces avermitilis MA-4680 hypothetical protein NP_822048.1 1044960 R 227882 CDS NP_822049.1 29827415 1212552 1045629..1047416 1 NC_003155.4 PF00497: Bacterial extracellular solute-binding proteins, family 3; solute-binding dependent transport lipoprotein 1047416 1212552 SAV_874 Streptomyces avermitilis MA-4680 solute-binding dependent transport lipoprotein NP_822049.1 1045629 D 227882 CDS NP_822050.1 29827416 1212553 complement(1047772..1048737) 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; proline iminopeptidase 1048737 pip 1212553 pip Streptomyces avermitilis MA-4680 proline iminopeptidase NP_822050.1 1047772 R 227882 CDS NP_822051.1 29827417 1212554 1049165..1049596 1 NC_003155.4 hypothetical protein 1049596 1212554 SAV_876 Streptomyces avermitilis MA-4680 hypothetical protein NP_822051.1 1049165 D 227882 CDS NP_822052.1 29827418 1210093 1050455..1050985 1 NC_003155.4 similar to Cpt(Q56148) chloramphenicol-producing Streptomyces venezuelae. Streptomyces coelicolor A3(2) has different resistance mechanism (probably efflux, CmlR); chloramphenicol 3-O phosphotransferase 1050985 cpt 1210093 cpt Streptomyces avermitilis MA-4680 chloramphenicol 3-O phosphotransferase NP_822052.1 1050455 D 227882 CDS NP_822053.1 29827419 1212555 1051615..1052112 1 NC_003155.4 PF00190: Cupin doamin, 100% same as SAV465; hypothetical protein 1052112 1212555 SAV_878 Streptomyces avermitilis MA-4680 hypothetical protein NP_822053.1 1051615 D 227882 CDS NP_822054.1 29827420 1212556 complement(1052915..1053874) 1 NC_003155.4 probably involving non-homologous end-joining; Ku70/Ku80 protein 1053874 ku2 1212556 ku2 Streptomyces avermitilis MA-4680 Ku70/Ku80 protein NP_822054.1 1052915 R 227882 CDS NP_822055.1 29827421 1212557 complement(1054267..1054536) 1 NC_003155.4 TetR family transcriptional regulator 1054536 1212557 SAV_880 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_822055.1 1054267 R 227882 CDS NP_822056.1 29827422 1212558 1054718..1055842 1 NC_003155.4 PF01360: Monooxygenase; monooxygenase 1055842 1212558 SAV_881 Streptomyces avermitilis MA-4680 monooxygenase NP_822056.1 1054718 D 227882 CDS NP_822057.1 29827423 1212559 complement(1056028..1056786) 1 NC_003155.4 TetR family transcriptional regulator 1056786 1212559 SAV_882 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_822057.1 1056028 R 227882 CDS NP_822058.1 29827424 1212560 1056846..1057706 1 NC_003155.4 PF01113: Dihydrodipicolinate reductase, N-terminus; hypothetical protein 1057706 1212560 SAV_883 Streptomyces avermitilis MA-4680 hypothetical protein NP_822058.1 1056846 D 227882 CDS NP_822059.1 29827425 1212561 1057857..1058840 1 NC_003155.4 PF00665: Integrase core domain; transposase 1058840 1212561 SAV_884 Streptomyces avermitilis MA-4680 transposase NP_822059.1 1057857 D 227882 CDS NP_822060.1 29827426 1212562 1059494..1059823 1 NC_003155.4 PF03992: Antibiotic biosynthesis monooxygenase; hypothetical protein 1059823 1212562 SAV_885 Streptomyces avermitilis MA-4680 hypothetical protein NP_822060.1 1059494 D 227882 CDS NP_822061.1 29827427 1212563 complement(1060061..1060657) 1 NC_003155.4 PF00753: Metallo-beta-lactamase superfamily; hypothetical protein 1060657 1212563 SAV_886 Streptomyces avermitilis MA-4680 hypothetical protein NP_822061.1 1060061 R 227882 CDS NP_822062.1 29827428 1212564 1061121..1065185 1 NC_003155.4 PF00754: F5/8 type C domain; glycosyl hydrolase 1065185 1212564 SAV_887 Streptomyces avermitilis MA-4680 glycosyl hydrolase NP_822062.1 1061121 D 227882 CDS NP_822063.1 29827429 1212565 complement(1065315..1066835) 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 1066835 1212565 SAV_888 Streptomyces avermitilis MA-4680 hydrolase NP_822063.1 1065315 R 227882 CDS NP_822064.1 29827430 1212566 complement(1066921..1067280) 1 NC_003155.4 hypothetical protein 1067280 1212566 SAV_889 Streptomyces avermitilis MA-4680 hypothetical protein NP_822064.1 1066921 R 227882 CDS NP_822065.1 29827431 1212567 1067692..1069515 1 NC_003155.4 hypothetical protein 1069515 1212567 SAV_890 Streptomyces avermitilis MA-4680 hypothetical protein NP_822065.1 1067692 D 227882 CDS NP_822066.1 29827432 1212568 complement(1069805..1070419) 1 NC_003155.4 quaternary amine transporter 1070419 1212568 SAV_891 Streptomyces avermitilis MA-4680 quaternary amine transporter NP_822066.1 1069805 R 227882 CDS NP_822067.1 29827433 1212569 complement(1070683..1071018) 1 NC_003155.4 hypothetical protein 1071018 1212569 SAV_892 Streptomyces avermitilis MA-4680 hypothetical protein NP_822067.1 1070683 R 227882 CDS NP_822068.1 29827434 1210094 complement(1071654..1071857) 1 NC_003155.4 cold shock protein 1071857 cspD2 1210094 cspD2 Streptomyces avermitilis MA-4680 cold shock protein NP_822068.1 1071654 R 227882 CDS NP_822069.1 29827435 1212570 complement(1072353..1072856) 1 NC_003155.4 hypothetical protein 1072856 1212570 SAV_894 Streptomyces avermitilis MA-4680 hypothetical protein NP_822069.1 1072353 R 227882 CDS NP_822070.1 29827436 1212571 complement(1073232..1073465) 1 NC_003155.4 hypothetical protein 1073465 1212571 SAV_895 Streptomyces avermitilis MA-4680 hypothetical protein NP_822070.1 1073232 R 227882 CDS NP_822071.1 29827437 1212572 1074296..1074871 1 NC_003155.4 PF02342: Bacterial stress protein; tellurium resistance protein 1074871 terD1 1212572 terD1 Streptomyces avermitilis MA-4680 tellurium resistance protein NP_822071.1 1074296 D 227882 CDS NP_822072.1 29827438 1212573 complement(1075047..1075406) 1 NC_003155.4 alpha-amylase inhibitor 1075406 1212573 SAV_897 Streptomyces avermitilis MA-4680 alpha-amylase inhibitor NP_822072.1 1075047 R 227882 CDS NP_822073.1 29827439 1210095 complement(1076865..1077479) 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 1077479 sig10 1210095 sig10 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_822073.1 1076865 R 227882 CDS NP_822074.1 29827440 1212574 complement(1077654..1078340) 1 NC_003155.4 hypothetical protein 1078340 1212574 SAV_899 Streptomyces avermitilis MA-4680 hypothetical protein NP_822074.1 1077654 R 227882 CDS NP_822075.1 29827441 1212575 complement(1078669..1079067) 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein 1079067 1212575 SAV_900 Streptomyces avermitilis MA-4680 hypothetical protein NP_822075.1 1078669 R 227882 CDS NP_822076.1 29827442 1212576 1079174..1080226 1 NC_003155.4 transcriptional regulator 1080226 1212576 SAV_901 Streptomyces avermitilis MA-4680 transcriptional regulator NP_822076.1 1079174 D 227882 CDS NP_822077.1 29827443 1212577 1080407..1080958 1 NC_003155.4 hypothetical protein 1080958 1212577 SAV_902 Streptomyces avermitilis MA-4680 hypothetical protein NP_822077.1 1080407 D 227882 CDS NP_822078.1 29827444 1212578 1081464..1082558 1 NC_003155.4 hypothetical protein 1082558 1212578 SAV_903 Streptomyces avermitilis MA-4680 hypothetical protein NP_822078.1 1081464 D 227882 CDS NP_822079.1 29827445 1212579 1082866..1083876 1 NC_003155.4 PF00248: Aldo/keto reductase family; oxidoreductase 1083876 1212579 SAV_904 Streptomyces avermitilis MA-4680 oxidoreductase NP_822079.1 1082866 D 227882 CDS NP_822080.1 29827446 1212580 complement(1084639..1084959) 1 NC_003155.4 hypothetical protein 1084959 1212580 SAV_905 Streptomyces avermitilis MA-4680 hypothetical protein NP_822080.1 1084639 R 227882 CDS NP_822081.1 29827447 1212581 complement(1085023..1086564) 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; protease 1086564 1212581 SAV_906 Streptomyces avermitilis MA-4680 protease NP_822081.1 1085023 R 227882 CDS NP_822082.1 29827448 1212582 complement(1086726..1087349) 1 NC_003155.4 hypothetical protein 1087349 1212582 SAV_907 Streptomyces avermitilis MA-4680 hypothetical protein NP_822082.1 1086726 R 227882 CDS NP_822083.1 29827449 1212583 1087677..1088615 1 NC_003155.4 PF01073: 3-beta hydroxysteroid dehydrogenase/isomerase family; dehydrogenase 1088615 1212583 SAV_908 Streptomyces avermitilis MA-4680 dehydrogenase NP_822083.1 1087677 D 227882 CDS NP_822084.1 29827450 1210096 1088612..1089535 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 1089535 sig11 1210096 sig11 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_822084.1 1088612 D 227882 CDS NP_822085.1 29827451 1212584 1089696..1090277 1 NC_003155.4 PF03358: NADPH-dependent FMN reductase; reductase 1090277 1212584 SAV_910 Streptomyces avermitilis MA-4680 reductase NP_822085.1 1089696 D 227882 CDS NP_822086.1 29827452 1212585 1090528..1091295 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 1091295 1212585 SAV_911 Streptomyces avermitilis MA-4680 dehydrogenase NP_822086.1 1090528 D 227882 CDS NP_822087.1 29827453 1212586 complement(1091689..1092819) 1 NC_003155.4 PF01360: Monooxygenase; pentachlorophenol 4-monooxygenase 1092819 pcpB 1212586 pcpB Streptomyces avermitilis MA-4680 pentachlorophenol 4-monooxygenase NP_822087.1 1091689 R 227882 CDS NP_822088.1 29827454 1212587 1092937..1093518 1 NC_003155.4 TetR family transcriptional regulator 1093518 1212587 SAV_913 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_822088.1 1092937 D 227882 CDS NP_822089.1 29827455 1212588 1093703..1094287 1 NC_003155.4 PF00582: Universal stress protein family; hypothetical protein 1094287 1212588 SAV_914 Streptomyces avermitilis MA-4680 hypothetical protein NP_822089.1 1093703 D 227882 CDS NP_822090.1 29827456 1212589 1094554..1094970 1 NC_003155.4 hypothetical protein 1094970 1212589 SAV_915 Streptomyces avermitilis MA-4680 hypothetical protein NP_822090.1 1094554 D 227882 CDS NP_822091.1 29827457 1210097 1094980..1096380 1 NC_003155.4 PF02784: Pyridoxal-dependent decarboxylase, pyridoxal binding domain; diaminopimelate decarboxylase 1096380 lysA2 1210097 lysA2 Streptomyces avermitilis MA-4680 diaminopimelate decarboxylase NP_822091.1 1094980 D 227882 CDS NP_822092.1 29827458 1210098 complement(1097100..1097768) 1 NC_003155.4 one of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; the C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C 1097768 kdpC 1210098 kdpC Streptomyces avermitilis MA-4680 potassium-transporting ATPase subunit C NP_822092.1 1097100 R 227882 CDS NP_822093.1 29827459 1210099 complement(1097793..1099877) 1 NC_003155.4 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B 1099877 kdpB 1210099 kdpB Streptomyces avermitilis MA-4680 potassium-transporting ATPase subunit B NP_822093.1 1097793 R 227882 CDS NP_822094.1 29827460 1210100 complement(1099967..1101631) 1 NC_003155.4 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 1101631 kdpA 1210100 kdpA Streptomyces avermitilis MA-4680 potassium-transporting ATPase subunit A NP_822094.1 1099967 R 227882 CDS NP_822095.1 29827461 1212590 complement(1101987..1102472) 1 NC_003155.4 hypothetical protein 1102472 1212590 SAV_920 Streptomyces avermitilis MA-4680 hypothetical protein NP_822095.1 1101987 R 227882 CDS NP_822096.1 29827462 1212591 complement(1102907..1103326) 1 NC_003155.4 PF01740: STAS domain; anti-sigma factor antagonist 1103326 1212591 SAV_921 Streptomyces avermitilis MA-4680 anti-sigma factor antagonist NP_822096.1 1102907 R 227882 CDS NP_822097.1 29827463 1212592 complement(1103319..1104566) 1 NC_003155.4 PF00785: PAC motif; magnesium or manganese-dependent protein phosphatase 1104566 prpC3 1212592 prpC3 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_822097.1 1103319 R 227882 CDS NP_822098.1 29827464 1212593 complement(1104566..1105369) 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 1105369 1212593 SAV_923 Streptomyces avermitilis MA-4680 hydrolase NP_822098.1 1104566 R 227882 CDS NP_822099.1 29827465 1212594 1105704..1108190 1 NC_003155.4 PF01590: GAF domain; magnesium or manganese-dependent protein phosphatase 1108190 prpC4 1212594 prpC4 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_822099.1 1105704 D 227882 CDS NP_822100.1 29827466 1212595 1108453..1109142 1 NC_003155.4 hypothetical protein 1109142 1212595 SAV_925 Streptomyces avermitilis MA-4680 hypothetical protein NP_822100.1 1108453 D 227882 CDS NP_822101.1 29827467 1212596 1109139..1119155 1 NC_003155.4 a giant polypeptide 3338 aa; transcriptional activator SRCAP-like protein 1119155 1212596 SAV_926 Streptomyces avermitilis MA-4680 transcriptional activator SRCAP-like protein NP_822101.1 1109139 D 227882 CDS NP_822102.1 29827468 1212597 1119155..1120723 1 NC_003155.4 hypothetical protein 1120723 1212597 SAV_927 Streptomyces avermitilis MA-4680 hypothetical protein NP_822102.1 1119155 D 227882 CDS NP_822103.1 29827469 1212598 1120720..1121583 1 NC_003155.4 hypothetical protein 1121583 1212598 SAV_928 Streptomyces avermitilis MA-4680 hypothetical protein NP_822103.1 1120720 D 227882 CDS NP_822104.1 29827470 1212599 1121580..1125176 1 NC_003155.4 hypothetical protein 1125176 1212599 SAV_929 Streptomyces avermitilis MA-4680 hypothetical protein NP_822104.1 1121580 D 227882 CDS NP_822105.1 29827471 1212600 1125173..1127746 1 NC_003155.4 N-acetylmuramoyl-L-alanine amidase 1127746 1212600 SAV_930 Streptomyces avermitilis MA-4680 N-acetylmuramoyl-L-alanine amidase NP_822105.1 1125173 D 227882 CDS NP_822106.1 29827472 1212601 complement(1127788..1128495) 1 NC_003155.4 two-component system response regulator 1128495 1212601 SAV_931 Streptomyces avermitilis MA-4680 two-component system response regulator NP_822106.1 1127788 R 227882 CDS NP_822107.1 29827473 1212602 complement(1128492..1129679) 1 NC_003155.4 two-component system sensor kinase 1129679 1212602 SAV_932 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_822107.1 1128492 R 227882 CDS NP_822108.1 29827474 1212603 1129772..1130797 1 NC_003155.4 ABC transporter ATP-binding protein 1130797 1212603 SAV_933 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_822108.1 1129772 D 227882 CDS NP_822109.1 29827475 1212604 1130794..1131567 1 NC_003155.4 ABC transporter permease 1131567 1212604 SAV_934 Streptomyces avermitilis MA-4680 ABC transporter permease NP_822109.1 1130794 D 227882 CDS NP_822110.1 29827476 1210101 1132045..1134894 1 NC_003155.4 positive response regulator for avermectin biosynthetic gene cluster, avermectin gene cluster; LuxR family transcriptional regulator 1134894 aveR 1210101 aveR Streptomyces avermitilis MA-4680 LuxR family transcriptional regulator NP_822110.1 1132045 D 227882 CDS NP_822111.1 29827477 1210102 complement(1134941..1135849) 1 NC_003155.4 avermectin gene cluster; C-5 ketoreductase 1135849 aveF 1210102 aveF Streptomyces avermitilis MA-4680 C-5 ketoreductase NP_822111.1 1134941 R 227882 CDS NP_822112.1 29827478 1210103 complement(1136629..1137480) 1 NC_003155.4 avermectin gene cluster; C5-O-methyltransferase 1137480 aveD 1210103 aveD Streptomyces avermitilis MA-4680 C5-O-methyltransferase NP_822112.1 1136629 R 227882 CDS NP_822113.1 29827479 1210104 1137817..1149735 1 NC_003155.4 avermectin gene cluster; type I polyketide synthase AVES 1 1149735 aveA1 1210104 aveA1 Streptomyces avermitilis MA-4680 type I polyketide synthase AVES 1 NP_822113.1 1137817 D 227882 CDS NP_822114.1 29827480 1210105 1149787..1168506 1 NC_003155.4 avermectin gene cluster; type I polyketide synthase AVES 2 1168506 aveA2 1210105 aveA2 Streptomyces avermitilis MA-4680 type I polyketide synthase AVES 2 NP_822114.1 1149787 D 227882 CDS NP_822115.1 29827481 1210106 1168503..1169546 1 NC_003155.4 avermectin gene cluster; AveC 1169546 aveC 1210106 aveC Streptomyces avermitilis MA-4680 AveC NP_822115.1 1168503 D 227882 CDS NP_822116.1 29827482 1210107 complement(1169630..1171000) 1 NC_003155.4 CYP171A1, avermectin gene cluster; cytochrome P450 hydroxylase 1171000 aveE 1210107 aveE Streptomyces avermitilis MA-4680 cytochrome P450 hydroxylase NP_822116.1 1169630 R 227882 CDS NP_822117.1 29827483 1210108 complement(1171152..1187750) 1 NC_003155.4 avermectin gene cluster; type I polyketide synthase AVES 3 1187750 aveA3 1210108 aveA3 Streptomyces avermitilis MA-4680 type I polyketide synthase AVES 3 NP_822117.1 1171152 R 227882 CDS NP_822118.1 29827484 1210109 complement(1187928..1202573) 1 NC_003155.4 avermectin gene cluster; type I polyketide synthase AVES 4 1202573 aveA4 1210109 aveA4 Streptomyces avermitilis MA-4680 type I polyketide synthase AVES 4 NP_822118.1 1187928 R 227882 CDS NP_822119.1 29827485 1210110 1202833..1203546 1 NC_003155.4 not involved in biosynthesis of avermectin, PF00106: short chain dehydrogenase; reductase 1203546 orf-1 1210110 orf-1 Streptomyces avermitilis MA-4680 reductase NP_822119.1 1202833 D 227882 CDS NP_822120.1 29827486 1210111 1203604..1204842 1 NC_003155.4 avermectin gene cluster, PF00201: UDP-glucoronosyl and UDP-glucosyl transferase; glycosyl transferase 1204842 aveBI 1210111 aveBI Streptomyces avermitilis MA-4680 glycosyl transferase NP_822120.1 1203604 D 227882 CDS NP_822121.1 29827487 1210112 complement(1204748..1205815) 1 NC_003155.4 avermectin gene cluster; dTDP-glucose 4,6-dehydratase 1205815 aveBII 1210112 aveBII Streptomyces avermitilis MA-4680 dTDP-glucose 4,6-dehydratase NP_822121.1 1204748 R 227882 CDS NP_822122.1 29827488 1210113 complement(1205812..1206711) 1 NC_003155.4 avermectin gene cluster; glucose-1-phosphate thymidyltransferase 1206711 aveBIII 1210113 aveBIII Streptomyces avermitilis MA-4680 glucose-1-phosphate thymidyltransferase NP_822122.1 1205812 R 227882 CDS NP_822123.1 29827489 1210114 1206837..1207868 1 NC_003155.4 avermectin gene cluster; dTDP-4-keto-6-deoxy-L-hexose 4-reductase 1207868 aveBIV 1210114 aveBIV Streptomyces avermitilis MA-4680 dTDP-4-keto-6-deoxy-L-hexose 4-reductase NP_822123.1 1206837 D 227882 CDS NP_822124.1 29827490 1210115 complement(1207922..1208599) 1 NC_003155.4 avermectin gene cluster; dTDP-4-keto-6-deoxyhexose 3,5-epimerase 1208599 aveBV 1210115 aveBV Streptomyces avermitilis MA-4680 dTDP-4-keto-6-deoxyhexose 3,5-epimerase NP_822124.1 1207922 R 227882 CDS NP_822125.1 29827491 1210116 complement(1208661..1210070) 1 NC_003155.4 avermectin gene cluster; dTDP-4-keto-6-deoxy-L-hexose2,3-dehydratase 1210070 aveBVI 1210116 aveBVI Streptomyces avermitilis MA-4680 dTDP-4-keto-6-deoxy-L-hexose2,3-dehydratase NP_822125.1 1208661 R 227882 CDS NP_822126.1 29827492 1210117 complement(1210067..1210840) 1 NC_003155.4 avermectin gene cluster; dTDP-6-deoxy-L-hexose 3-O-methyltransferase 1210840 aveBVII 1210117 aveBVII Streptomyces avermitilis MA-4680 dTDP-6-deoxy-L-hexose 3-O-methyltransferase NP_822126.1 1210067 R 227882 CDS NP_822127.1 29827493 1210118 complement(1210927..1211970) 1 NC_003155.4 avermectin gene cluster; dTDP-4-keto-6-deoxy-L-hexose 2,3-reductase 1211970 aveBVIII 1210118 aveBVIII Streptomyces avermitilis MA-4680 dTDP-4-keto-6-deoxy-L-hexose 2,3-reductase NP_822127.1 1210927 R 227882 CDS NP_822128.1 29827494 1210119 1212208..1212960 1 NC_003155.4 avermectin gene cluster; thioesterase 1212960 aveG 1210119 aveG Streptomyces avermitilis MA-4680 thioesterase NP_822128.1 1212208 D 227882 CDS NP_822129.1 29827495 1210120 1213312..1214895 1 NC_003155.4 glutamate synthase(ferredoxin) 1214895 yerD1 1210120 yerD1 Streptomyces avermitilis MA-4680 glutamate synthase(ferredoxin) NP_822129.1 1213312 D 227882 CDS NP_822130.1 29827496 1212605 1214909..1216672 1 NC_003155.4 PF02776: Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; pyruvate dehydrogenase/oxidase FAD and thiamine PPi cofactors 1216672 poxB1 1212605 poxB1 Streptomyces avermitilis MA-4680 pyruvate dehydrogenase/oxidase FAD and thiamine PPi cofactors NP_822130.1 1214909 D 227882 CDS NP_822131.1 29827497 1212606 complement(1216895..1218094) 1 NC_003155.4 PF01590: GAF domain; magnesium or manganese-dependent protein phosphatase 1218094 prpB2 1212606 prpB2 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_822131.1 1216895 R 227882 CDS NP_822132.1 29827498 1212607 1218275..1218448 1 NC_003155.4 PF05532: CsbD-like; hypothetical protein 1218448 1212607 SAV_957 Streptomyces avermitilis MA-4680 hypothetical protein NP_822132.1 1218275 D 227882 CDS NP_822133.1 29827499 1212608 1218971..1219141 1 NC_003155.4 hypothetical protein 1219141 1212608 SAV_958 Streptomyces avermitilis MA-4680 hypothetical protein NP_822133.1 1218971 D 227882 CDS NP_822134.1 29827500 1212609 1219332..1219616 1 NC_003155.4 hypothetical protein 1219616 1212609 SAV_959 Streptomyces avermitilis MA-4680 hypothetical protein NP_822134.1 1219332 D 227882 CDS NP_822135.1 29827501 1212610 1219827..1220234 1 NC_003155.4 PF04946: DGPF domain; hypothetical protein 1220234 1212610 SAV_960 Streptomyces avermitilis MA-4680 hypothetical protein NP_822135.1 1219827 D 227882 CDS NP_822136.1 29827502 1210121 1220243..1221388 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 1221388 sig12 1210121 sig12 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_822136.1 1220243 D 227882 CDS NP_822137.1 29827503 1212611 1221488..1221802 1 NC_003155.4 hypothetical protein 1221802 1212611 SAV_962 Streptomyces avermitilis MA-4680 hypothetical protein NP_822137.1 1221488 D 227882 CDS NP_822138.1 29827504 1212612 1222029..1223162 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; glutathione-independent formaldehyde dehydrogenase 1223162 fdhA 1212612 fdhA Streptomyces avermitilis MA-4680 glutathione-independent formaldehyde dehydrogenase NP_822138.1 1222029 D 227882 CDS NP_822139.1 29827505 1212613 1223517..1223957 1 NC_003155.4 PF02987: Late embryogenesis abundant protein; hypothetical protein 1223957 1212613 SAV_964 Streptomyces avermitilis MA-4680 hypothetical protein NP_822139.1 1223517 D 227882 CDS NP_822140.1 29827506 1212614 complement(1224632..1225057) 1 NC_003155.4 PF01638: Transcriptional regulator; transcriptional regulator 1225057 1212614 SAV_965 Streptomyces avermitilis MA-4680 transcriptional regulator NP_822140.1 1224632 R 227882 CDS NP_822141.1 29827507 1212615 1225192..1225653 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein 1225653 1212615 SAV_966 Streptomyces avermitilis MA-4680 hypothetical protein NP_822141.1 1225192 D 227882 CDS NP_822142.1 29827508 1212616 complement(1226230..1227438) 1 NC_003155.4 glycosyl hydrolase 1227438 1212616 SAV_967 Streptomyces avermitilis MA-4680 glycosyl hydrolase NP_822142.1 1226230 R 227882 CDS NP_822143.1 29827509 1212617 complement(1227720..1228718) 1 NC_003155.4 PF02653: Branched-chain amino acid transport system / permease component; ribose/xylose/arabinose/galactoside ABC transporter permease 1228718 1212617 SAV_968 Streptomyces avermitilis MA-4680 ribose/xylose/arabinose/galactoside ABC transporter permease NP_822143.1 1227720 R 227882 CDS NP_822144.1 29827510 1212618 complement(1228751..1229716) 1 NC_003155.4 sugar ABC transporter permease 1229716 1212618 SAV_969 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_822144.1 1228751 R 227882 CDS NP_822145.1 29827511 1212619 complement(1229709..1231277) 1 NC_003155.4 sugar ABC transporter ATP-binding protein 1231277 1212619 SAV_970 Streptomyces avermitilis MA-4680 sugar ABC transporter ATP-binding protein NP_822145.1 1229709 R 227882 CDS NP_822146.1 29827512 1212620 complement(1231383..1232498) 1 NC_003155.4 sugar ABC transporter periplasmic solute-binding protein 1232498 1212620 SAV_971 Streptomyces avermitilis MA-4680 sugar ABC transporter periplasmic solute-binding protein NP_822146.1 1231383 R 227882 CDS NP_822147.1 29827513 1212621 complement(1232679..1233692) 1 NC_003155.4 LacI family transcriptional regulator 1233692 1212621 SAV_972 Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_822147.1 1232679 R 227882 CDS NP_822148.1 29827514 1212622 1233874..1236525 1 NC_003155.4 PF07691: PA14 domain; hydrolase 1236525 1212622 SAV_973 Streptomyces avermitilis MA-4680 hydrolase NP_822148.1 1233874 D 227882 CDS NP_822149.1 29827515 1212623 1236913..1237734 1 NC_003155.4 non-heme chloroperoxidase 1237734 1212623 SAV_974 Streptomyces avermitilis MA-4680 non-heme chloroperoxidase NP_822149.1 1236913 D 227882 CDS NP_822150.1 29827516 1210122 complement(1238122..1239828) 1 NC_003155.4 serine/threonine protein kinase 1239828 pkn2 1210122 pkn2 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_822150.1 1238122 R 227882 CDS NP_822151.1 29827517 1212624 1239936..1240271 1 NC_003155.4 nucleotide-binding protein 1240271 1212624 SAV_976 Streptomyces avermitilis MA-4680 nucleotide-binding protein NP_822151.1 1239936 D 227882 CDS NP_822152.2 57833855 1212625 1240310..1241584 1 NC_003155.4 IS4 family transposase 1241584 1212625 SAV_977 Streptomyces avermitilis MA-4680 IS4 family transposase NP_822152.2 1240310 D 227882 CDS NP_822153.1 29827519 1212626 complement(1241684..1242469) 1 NC_003155.4 PF00665: Integrase core domain; transposase 1242469 1212626 SAV_978 Streptomyces avermitilis MA-4680 transposase NP_822153.1 1241684 R 227882 CDS NP_822154.1 29827520 1212627 complement(1242469..1242702) 1 NC_003155.4 transposase 1242702 1212627 SAV_979 Streptomyces avermitilis MA-4680 transposase NP_822154.1 1242469 R 227882 CDS YP_001621481.1 162960847 5815322 complement(1242699..1243340) 1 NC_003155.4 hypothetical protein 1243340 5815322 SAV_7578 Streptomyces avermitilis MA-4680 hypothetical protein YP_001621481.1 1242699 R 227882 CDS NP_822155.1 29827521 1212628 1243471..1244862 1 NC_003155.4 GntR family transcriptional regulator 1244862 1212628 SAV_980 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_822155.1 1243471 D 227882 CDS NP_822156.1 29827522 1212629 1244924..1245541 1 NC_003155.4 hypothetical protein 1245541 1212629 SAV_981 Streptomyces avermitilis MA-4680 hypothetical protein NP_822156.1 1244924 D 227882 CDS NP_822157.1 29827523 1212630 1245553..1245675 1 NC_003155.4 hypothetical protein 1245675 1212630 SAV_982 Streptomyces avermitilis MA-4680 hypothetical protein NP_822157.1 1245553 D 227882 CDS NP_822158.1 29827524 1212631 1246455..1247330 1 NC_003155.4 methyltransferase 1247330 1212631 SAV_983 Streptomyces avermitilis MA-4680 methyltransferase NP_822158.1 1246455 D 227882 CDS NP_822159.1 29827525 1212632 complement(1247421..1250234) 1 NC_003155.4 hypothetical protein 1250234 1212632 SAV_984 Streptomyces avermitilis MA-4680 hypothetical protein NP_822159.1 1247421 R 227882 CDS NP_822160.1 29827526 1212633 complement(1250231..1251346) 1 NC_003155.4 PF00004: ATPase family associated with various cellular activities (AAA); hypothetical protein 1251346 1212633 SAV_985 Streptomyces avermitilis MA-4680 hypothetical protein NP_822160.1 1250231 R 227882 CDS NP_822161.1 29827527 1212634 complement(1251356..1252792) 1 NC_003155.4 PF05762: VWA domain containing CoxE-like protein; hypothetical protein 1252792 1212634 SAV_986 Streptomyces avermitilis MA-4680 hypothetical protein NP_822161.1 1251356 R 227882 CDS NP_822162.1 29827528 1212635 complement(1252789..1254189) 1 NC_003155.4 hypothetical protein 1254189 1212635 SAV_987 Streptomyces avermitilis MA-4680 hypothetical protein NP_822162.1 1252789 R 227882 CDS NP_822163.1 29827529 1212636 complement(1254189..1254668) 1 NC_003155.4 hypothetical protein 1254668 1212636 SAV_988 Streptomyces avermitilis MA-4680 hypothetical protein NP_822163.1 1254189 R 227882 CDS NP_822164.1 29827530 1212637 1254946..1255869 1 NC_003155.4 phosphotransferase 1255869 1212637 SAV_989 Streptomyces avermitilis MA-4680 phosphotransferase NP_822164.1 1254946 D 227882 CDS NP_822165.1 29827531 1212638 1256164..1256619 1 NC_003155.4 protein 1256619 1212638 SAV_990 Streptomyces avermitilis MA-4680 protein NP_822165.1 1256164 D 227882 CDS NP_822166.1 29827532 1212639 1257106..1257552 1 NC_003155.4 hypothetical protein 1257552 1212639 SAV_991 Streptomyces avermitilis MA-4680 hypothetical protein NP_822166.1 1257106 D 227882 CDS NP_822167.1 29827533 1212640 1257609..1258790 1 NC_003155.4 PF03631: Ribonuclease BN-like family; ribonuclease BN family membrane protein 1258790 1212640 SAV_992 Streptomyces avermitilis MA-4680 ribonuclease BN family membrane protein NP_822167.1 1257609 D 227882 CDS NP_822168.1 29827534 1212641 complement(1258992..1259420) 1 NC_003155.4 cysteine transferase 1259420 1212641 SAV_993 Streptomyces avermitilis MA-4680 cysteine transferase NP_822168.1 1258992 R 227882 CDS NP_822169.1 29827535 1212642 1259676..1260971 1 NC_003155.4 conventional protein tyrosine phosphatase 1260971 ptpA1 1212642 ptpA1 Streptomyces avermitilis MA-4680 conventional protein tyrosine phosphatase NP_822169.1 1259676 D 227882 CDS NP_822170.1 29827536 1212643 complement(1261279..1261713) 1 NC_003155.4 hypothetical protein 1261713 1212643 SAV_995 Streptomyces avermitilis MA-4680 hypothetical protein NP_822170.1 1261279 R 227882 CDS NP_822171.1 29827537 1212644 1262191..1262457 1 NC_003155.4 hypothetical protein 1262457 1212644 SAV_996 Streptomyces avermitilis MA-4680 hypothetical protein NP_822171.1 1262191 D 227882 CDS NP_822172.1 29827538 1210123 1262450..1263121 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 1263121 sig13 1210123 sig13 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_822172.1 1262450 D 227882 CDS NP_822173.1 29827539 1212645 1263118..1264992 1 NC_003155.4 PF01435: Peptidase family M48; hypothetical protein 1264992 1212645 SAV_998 Streptomyces avermitilis MA-4680 hypothetical protein NP_822173.1 1263118 D 227882 CDS NP_822174.1 29827540 1212646 complement(1265082..1266182) 1 NC_003155.4 ATP-dependent carboxylate-amine ligase; carboxylate-amine ligase 1266182 1212646 SAV_999 Streptomyces avermitilis MA-4680 carboxylate-amine ligase NP_822174.1 1265082 R 227882 CDS NP_822175.1 29827541 1210124 complement(1266577..1267947) 1 NC_003155.4 PF00089: Trypsin; serine protease 1267947 sprC 1210124 sprC Streptomyces avermitilis MA-4680 serine protease NP_822175.1 1266577 R 227882 CDS NP_822176.1 29827542 1212647 complement(1268233..1269867) 1 NC_003155.4 PF01593: Flavin containing amine oxidoreductase; dehydrogenase 1269867 1212647 SAV_1001 Streptomyces avermitilis MA-4680 dehydrogenase NP_822176.1 1268233 R 227882 CDS NP_822177.1 29827543 1212648 complement(1269949..1270425) 1 NC_003155.4 PF03364: Streptomyces cyclase/dehydrase; hypothetical protein 1270425 1212648 SAV_1002 Streptomyces avermitilis MA-4680 hypothetical protein NP_822177.1 1269949 R 227882 CDS NP_822178.1 29827544 1212649 complement(1270524..1271402) 1 NC_003155.4 PF00106: short chain dehydrogenase; short chain dehydrogenase 1271402 1212649 SAV_1003 Streptomyces avermitilis MA-4680 short chain dehydrogenase NP_822178.1 1270524 R 227882 CDS NP_822179.1 29827545 1212650 1271761..1272111 1 NC_003155.4 hypothetical protein 1272111 1212650 SAV_1004 Streptomyces avermitilis MA-4680 hypothetical protein NP_822179.1 1271761 D 227882 CDS NP_822180.1 29827546 1212651 complement(1272152..1272571) 1 NC_003155.4 PF00571: CBS domain; oxidoreductase 1272571 1212651 SAV_1005 Streptomyces avermitilis MA-4680 oxidoreductase NP_822180.1 1272152 R 227882 CDS NP_822181.1 29827547 1212652 complement(1272888..1273169) 1 NC_003155.4 PF04226: Transglycosylase associated protein; hypothetical protein 1273169 1212652 SAV_1006 Streptomyces avermitilis MA-4680 hypothetical protein NP_822181.1 1272888 R 227882 CDS NP_822182.1 29827548 1212653 1273736..1274263 1 NC_003155.4 hypothetical protein 1274263 1212653 SAV_1007 Streptomyces avermitilis MA-4680 hypothetical protein NP_822182.1 1273736 D 227882 CDS NP_822183.1 29827549 1212654 1274688..1276823 1 NC_003155.4 hypothetical protein 1276823 1212654 SAV_1008 Streptomyces avermitilis MA-4680 hypothetical protein NP_822183.1 1274688 D 227882 CDS NP_822184.1 29827550 1212655 1276910..1278451 1 NC_003155.4 glycosyltransferase 1278451 1212655 SAV_1009 Streptomyces avermitilis MA-4680 glycosyltransferase NP_822184.1 1276910 D 227882 CDS NP_822185.1 29827551 1212656 1278448..1279854 1 NC_003155.4 hypothetical protein 1279854 1212656 SAV_1010 Streptomyces avermitilis MA-4680 hypothetical protein NP_822185.1 1278448 D 227882 CDS NP_822186.1 29827552 1210125 1280007..1280801 1 NC_003155.4 UDP-glucose 4-epimerase 1280801 galE5 1210125 galE5 Streptomyces avermitilis MA-4680 UDP-glucose 4-epimerase NP_822186.1 1280007 D 227882 CDS NP_822187.1 29827553 1212657 1280798..1281016 1 NC_003155.4 hypothetical protein 1281016 1212657 SAV_1012 Streptomyces avermitilis MA-4680 hypothetical protein NP_822187.1 1280798 D 227882 CDS NP_822188.1 29827554 1210126 1281049..1281762 1 NC_003155.4 mannose-1-phosphate guanyltransferase 1281762 mpg2 1210126 mpg2 Streptomyces avermitilis MA-4680 mannose-1-phosphate guanyltransferase NP_822188.1 1281049 D 227882 CDS NP_822189.1 29827555 1212658 1281770..1282696 1 NC_003155.4 NDP-hexose 4-ketoreductase 1282696 1212658 SAV_1014 Streptomyces avermitilis MA-4680 NDP-hexose 4-ketoreductase NP_822189.1 1281770 D 227882 CDS NP_822190.1 29827556 1212659 1282693..1283355 1 NC_003155.4 hypothetical protein 1283355 1212659 SAV_1015 Streptomyces avermitilis MA-4680 hypothetical protein NP_822190.1 1282693 D 227882 CDS NP_822191.1 29827557 1212660 complement(1283443..1283901) 1 NC_003155.4 hypothetical protein 1283901 1212660 SAV_1016 Streptomyces avermitilis MA-4680 hypothetical protein NP_822191.1 1283443 R 227882 CDS NP_822192.1 29827558 1212661 1284066..1284428 1 NC_003155.4 PF07300: Protein of unknown function (DUF1452); hypothetical protein 1284428 1212661 SAV_1017 Streptomyces avermitilis MA-4680 hypothetical protein NP_822192.1 1284066 D 227882 CDS NP_822193.1 29827559 1212662 complement(1284484..1285032) 1 NC_003155.4 PF06532: Protein of unknown function (DUF1109); integral membrane protein 1285032 1212662 SAV_1018 Streptomyces avermitilis MA-4680 integral membrane protein NP_822193.1 1284484 R 227882 CDS NP_822194.1 29827560 1210127 complement(1285187..1286689) 1 NC_003155.4 crt gene cluster, conversion of beta-carotene to isorenieratene; beta-carotene desaturase/methylase 1286689 crtU 1210127 crtU Streptomyces avermitilis MA-4680 beta-carotene desaturase/methylase NP_822194.1 1285187 R 227882 CDS NP_822195.1 29827561 1210128 complement(1286743..1287474) 1 NC_003155.4 crt gene cluster; methyltransferase 1287474 crtT 1210128 crtT Streptomyces avermitilis MA-4680 methyltransferase NP_822195.1 1286743 R 227882 CDS NP_822196.1 29827562 1210129 complement(1287518..1288711) 1 NC_003155.4 crt gene cluster; lycopene cyclase 1288711 crtY 1210129 crtY Streptomyces avermitilis MA-4680 lycopene cyclase NP_822196.1 1287518 R 227882 CDS NP_822197.2 57833856 1210130 1289024..1290265 1 NC_003155.4 crt gene cluster, probably geranylgeranyl pyrophosphate synthase; polyprenyl diphosphate synthase 1290265 crtE 1210130 crtE Streptomyces avermitilis MA-4680 polyprenyl diphosphate synthase NP_822197.2 1289024 D 227882 CDS NP_822198.1 29827564 1210131 1290262..1291803 1 NC_003155.4 crt gene cluster; phytoene desaturase 1291803 crtI 1210131 crtI Streptomyces avermitilis MA-4680 phytoene desaturase NP_822198.1 1290262 D 227882 CDS NP_822199.1 29827565 1210132 1291800..1292828 1 NC_003155.4 crt gene cluster; phytoene synthase 1292828 crtB 1210132 crtB Streptomyces avermitilis MA-4680 phytoene synthase NP_822199.1 1291800 D 227882 CDS NP_822200.1 29827566 1210133 1292825..1293904 1 NC_003155.4 crt gene cluster; methylesterase 1293904 crtV 1210133 crtV Streptomyces avermitilis MA-4680 methylesterase NP_822200.1 1292825 D 227882 CDS NP_822201.1 29827567 1212663 complement(1294125..1296224) 1 NC_003155.4 PF00652: QXW lectin repeat; protein 1296224 1212663 SAV_1026 Streptomyces avermitilis MA-4680 protein NP_822201.1 1294125 R 227882 CDS NP_822202.1 29827568 1210134 complement(1296307..1298349) 1 NC_003155.4 beta-galactosidase 1298349 bga1 1210134 bga1 Streptomyces avermitilis MA-4680 beta-galactosidase NP_822202.1 1296307 R 227882 CDS NP_822203.1 29827569 1212664 complement(1298401..1299738) 1 NC_003155.4 PF00497: Bacterial extracellular solute-binding proteins, family 3; solute-binding lipoprotein 1299738 1212664 SAV_1028 Streptomyces avermitilis MA-4680 solute-binding lipoprotein NP_822203.1 1298401 R 227882 CDS NP_822204.1 29827570 1212665 complement(1299830..1300786) 1 NC_003155.4 ABC transporter permease 1300786 1212665 SAV_1029 Streptomyces avermitilis MA-4680 ABC transporter permease NP_822204.1 1299830 R 227882 CDS NP_822205.1 29827571 1212666 complement(1300791..1301717) 1 NC_003155.4 ABC transporter permease 1301717 1212666 SAV_1030 Streptomyces avermitilis MA-4680 ABC transporter permease NP_822205.1 1300791 R 227882 CDS NP_822206.1 29827572 1212667 1301900..1302979 1 NC_003155.4 LacI family transcriptional regulator 1302979 1212667 SAV_1031 Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_822206.1 1301900 D 227882 CDS NP_822207.1 29827573 1212668 1303150..1303467 1 NC_003155.4 hypothetical protein 1303467 1212668 SAV_1032 Streptomyces avermitilis MA-4680 hypothetical protein NP_822207.1 1303150 D 227882 CDS NP_822208.1 29827574 1212669 1303909..1306188 1 NC_003155.4 PF05976: Bacterial membrane protein of unknown function (DUF893); integral membrane protein 1306188 1212669 SAV_1033 Streptomyces avermitilis MA-4680 integral membrane protein NP_822208.1 1303909 D 227882 CDS NP_822209.1 29827575 1212670 complement(1306217..1307035) 1 NC_003155.4 hypothetical protein 1307035 1212670 SAV_1034 Streptomyces avermitilis MA-4680 hypothetical protein NP_822209.1 1306217 R 227882 CDS NP_822210.1 29827576 1212671 complement(1307347..1308420) 1 NC_003155.4 ATP-NAD kinase 1308420 1212671 SAV_1035 Streptomyces avermitilis MA-4680 ATP-NAD kinase NP_822210.1 1307347 R 227882 CDS NP_822211.1 29827577 1212672 complement(1308470..1309264) 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 1309264 1212672 SAV_1036 Streptomyces avermitilis MA-4680 dehydrogenase NP_822211.1 1308470 R 227882 CDS NP_822212.1 29827578 1212673 complement(1309966..1312341) 1 NC_003155.4 PF02868: Thermolysin metallopeptidase, alpha-helical domain; neutral zinc metalloprotease 1312341 1212673 SAV_1037 Streptomyces avermitilis MA-4680 neutral zinc metalloprotease NP_822212.1 1309966 R 227882 CDS NP_822213.1 29827579 1210135 complement(1312721..1313665) 1 NC_003155.4 porphobilinogen deaminase 1313665 hemC2 1210135 hemC2 Streptomyces avermitilis MA-4680 porphobilinogen deaminase NP_822213.1 1312721 R 227882 CDS NP_822214.1 29827580 1212674 complement(1313907..1314851) 1 NC_003155.4 PF00144: Beta-lactamase; hypothetical protein 1314851 1212674 SAV_1039 Streptomyces avermitilis MA-4680 hypothetical protein NP_822214.1 1313907 R 227882 CDS NP_822215.1 29827581 1212675 complement(1315062..1315349) 1 NC_003155.4 hypothetical protein 1315349 1212675 SAV_1040 Streptomyces avermitilis MA-4680 hypothetical protein NP_822215.1 1315062 R 227882 CDS NP_822216.1 29827582 1212676 1315431..1316003 1 NC_003155.4 hypothetical protein 1316003 1212676 SAV_1041 Streptomyces avermitilis MA-4680 hypothetical protein NP_822216.1 1315431 D 227882 CDS NP_822217.1 29827583 1212677 complement(1316740..1318020) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; hypothetical protein 1318020 1212677 SAV_1042 Streptomyces avermitilis MA-4680 hypothetical protein NP_822217.1 1316740 R 227882 CDS NP_822218.1 29827584 1212678 complement(1318574..1320019) 1 NC_003155.4 alpha-arabinofuranosidase II 1320019 1212678 SAV_1043 Streptomyces avermitilis MA-4680 alpha-arabinofuranosidase II NP_822218.1 1318574 R 227882 CDS NP_822219.1 29827585 1212679 complement(1320038..1321573) 1 NC_003155.4 PF04616: Glycosyl hydrolases family 43; hydrolase 1321573 1212679 SAV_1044 Streptomyces avermitilis MA-4680 hydrolase NP_822219.1 1320038 R 227882 CDS NP_822220.1 29827586 1212680 complement(1321655..1322329) 1 NC_003155.4 hypothetical protein 1322329 1212680 SAV_1045 Streptomyces avermitilis MA-4680 hypothetical protein NP_822220.1 1321655 R 227882 CDS NP_822221.1 29827587 1212681 complement(1322480..1323022) 1 NC_003155.4 hypothetical protein 1323022 1212681 SAV_1046 Streptomyces avermitilis MA-4680 hypothetical protein NP_822221.1 1322480 R 227882 CDS NP_822222.1 29827588 1212682 1323552..1323782 1 NC_003155.4 regulatory protein 1323782 1212682 SAV_1047 Streptomyces avermitilis MA-4680 regulatory protein NP_822222.1 1323552 D 227882 CDS NP_822223.1 29827589 1212683 1323943..1324863 1 NC_003155.4 DNA-binding protein 1324863 1212683 SAV_1048 Streptomyces avermitilis MA-4680 DNA-binding protein NP_822223.1 1323943 D 227882 CDS NP_822224.1 29827590 1212684 complement(1324945..1325763) 1 NC_003155.4 PF04672: Protein of unknown function (DUF574); hypothetical protein 1325763 1212684 SAV_1049 Streptomyces avermitilis MA-4680 hypothetical protein NP_822224.1 1324945 R 227882 CDS NP_822225.1 29827591 1212685 complement(1325884..1326741) 1 NC_003155.4 PF00248: Aldo/keto reductase family; oxidoreductase 1326741 1212685 SAV_1050 Streptomyces avermitilis MA-4680 oxidoreductase NP_822225.1 1325884 R 227882 CDS NP_822226.1 29827592 1212686 1327109..1328002 1 NC_003155.4 PF01408: Oxidoreductase family, NAD-binding Rossmann fold; oxidoreductase 1328002 1212686 SAV_1051 Streptomyces avermitilis MA-4680 oxidoreductase NP_822226.1 1327109 D 227882 CDS NP_822227.1 29827593 1212687 complement(1328062..1328871) 1 NC_003155.4 PF04672: Protein of unknown function (DUF574); hypothetical protein 1328871 1212687 SAV_1052 Streptomyces avermitilis MA-4680 hypothetical protein NP_822227.1 1328062 R 227882 CDS NP_822228.1 29827594 1212688 1329176..1330375 1 NC_003155.4 sugar hydrolase 1330375 1212688 SAV_1053 Streptomyces avermitilis MA-4680 sugar hydrolase NP_822228.1 1329176 D 227882 CDS NP_822229.1 29827595 1212689 complement(1330445..1332496) 1 NC_003155.4 PF00989: PAS domain, PF01590: GAF domain; magnesium or manganese-dependent protein phosphatase 1332496 prpJ4 1212689 prpJ4 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_822229.1 1330445 R 227882 CDS NP_822230.1 29827596 1212690 complement(1332766..1333503) 1 NC_003155.4 PF03861: ANTAR domain; hypothetical protein 1333503 1212690 SAV_1055 Streptomyces avermitilis MA-4680 hypothetical protein NP_822230.1 1332766 R 227882 CDS NP_822231.1 29827597 1212691 complement(1333655..1334098) 1 NC_003155.4 MarR family transcriptional regulator 1334098 1212691 SAV_1056 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_822231.1 1333655 R 227882 CDS NP_822232.1 29827598 1212692 complement(1334264..1334701) 1 NC_003155.4 hypothetical protein 1334701 1212692 SAV_1057 Streptomyces avermitilis MA-4680 hypothetical protein NP_822232.1 1334264 R 227882 CDS NP_822233.1 29827599 1212693 complement(1334840..1336405) 1 NC_003155.4 hypothetical protein 1336405 1212693 SAV_1058 Streptomyces avermitilis MA-4680 hypothetical protein NP_822233.1 1334840 R 227882 CDS NP_822234.1 29827600 1212694 1336683..1337606 1 NC_003155.4 PF04471: Restriction endonuclease; hypothetical protein 1337606 1212694 SAV_1059 Streptomyces avermitilis MA-4680 hypothetical protein NP_822234.1 1336683 D 227882 CDS NP_822235.1 29827601 1212695 1337762..1338721 1 NC_003155.4 PF03631: Ribonuclease BN-like family; ribonuclease BN 1338721 1212695 SAV_1060 Streptomyces avermitilis MA-4680 ribonuclease BN NP_822235.1 1337762 D 227882 CDS NP_822236.1 29827602 1212696 complement(1339060..1340271) 1 NC_003155.4 aminotransferase 1340271 1212696 SAV_1061 Streptomyces avermitilis MA-4680 aminotransferase NP_822236.1 1339060 R 227882 CDS NP_822237.1 29827603 1212697 complement(1340359..1341237) 1 NC_003155.4 hypothetical protein 1341237 1212697 SAV_1062 Streptomyces avermitilis MA-4680 hypothetical protein NP_822237.1 1340359 R 227882 CDS NP_822238.1 29827604 1212698 complement(1341421..1341708) 1 NC_003155.4 hypothetical protein 1341708 1212698 SAV_1063 Streptomyces avermitilis MA-4680 hypothetical protein NP_822238.1 1341421 R 227882 CDS NP_822239.1 29827605 1212699 1342008..1343222 1 NC_003155.4 phospholipase 1343222 1212699 SAV_1064 Streptomyces avermitilis MA-4680 phospholipase NP_822239.1 1342008 D 227882 CDS NP_822240.1 29827606 1212700 complement(1343403..1344437) 1 NC_003155.4 PF00043: Glutathione S-transferase, C-terminal domain; hypothetical protein 1344437 1212700 SAV_1065 Streptomyces avermitilis MA-4680 hypothetical protein NP_822240.1 1343403 R 227882 CDS NP_822241.1 29827607 1212701 1344973..1345542 1 NC_003155.4 hypothetical protein 1345542 1212701 SAV_1066 Streptomyces avermitilis MA-4680 hypothetical protein NP_822241.1 1344973 D 227882 CDS NP_822242.1 29827608 1212702 complement(1345801..1346481) 1 NC_003155.4 PF00106: short chain dehydrogenase; short chain dehydrogenase 1346481 1212702 SAV_1067 Streptomyces avermitilis MA-4680 short chain dehydrogenase NP_822242.1 1345801 R 227882 CDS NP_822243.1 29827609 1212703 1346651..1347208 1 NC_003155.4 TetR family transcriptional regulator 1347208 1212703 SAV_1068 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_822243.1 1346651 D 227882 CDS NP_822244.1 29827610 1212704 complement(1347446..1348486) 1 NC_003155.4 PF00753: Metallo-beta-lactamase superfamily; hypothetical protein 1348486 1212704 SAV_1069 Streptomyces avermitilis MA-4680 hypothetical protein NP_822244.1 1347446 R 227882 CDS NP_822245.1 29827611 1212705 complement(1348483..1349763) 1 NC_003155.4 hypothetical protein 1349763 1212705 SAV_1070 Streptomyces avermitilis MA-4680 hypothetical protein NP_822245.1 1348483 R 227882 CDS NP_822246.1 29827612 1212706 complement(1349760..1350932) 1 NC_003155.4 hypothetical protein 1350932 1212706 SAV_1071 Streptomyces avermitilis MA-4680 hypothetical protein NP_822246.1 1349760 R 227882 CDS NP_822247.1 29827613 1212707 1351064..1352230 1 NC_003155.4 hypothetical protein 1352230 1212707 SAV_1072 Streptomyces avermitilis MA-4680 hypothetical protein NP_822247.1 1351064 D 227882 CDS NP_822248.1 29827614 1212708 1352542..1352922 1 NC_003155.4 hypothetical protein 1352922 1212708 SAV_1073 Streptomyces avermitilis MA-4680 hypothetical protein NP_822248.1 1352542 D 227882 CDS NP_822249.1 29827615 1210136 1352919..1353386 1 NC_003155.4 PF00578: AhpC/TSA family; bacterioferritin comigratory protein 1353386 bcp1 1210136 bcp1 Streptomyces avermitilis MA-4680 bacterioferritin comigratory protein NP_822249.1 1352919 D 227882 CDS NP_822250.1 29827616 1212709 complement(1353464..1354747) 1 NC_003155.4 PF00657: GDSL-like Lipase/Acylhydrolase; protein 1354747 1212709 SAV_1075 Streptomyces avermitilis MA-4680 protein NP_822250.1 1353464 R 227882 CDS NP_822251.1 29827617 1212710 complement(1354744..1357158) 1 NC_003155.4 hypothetical protein 1357158 1212710 SAV_1076 Streptomyces avermitilis MA-4680 hypothetical protein NP_822251.1 1354744 R 227882 CDS NP_822252.1 29827618 1212711 complement(1357289..1359115) 1 NC_003155.4 melibiase 1359115 1212711 SAV_1077 Streptomyces avermitilis MA-4680 melibiase NP_822252.1 1357289 R 227882 CDS NP_822253.1 29827619 1212712 complement(1359193..1360014) 1 NC_003155.4 ABC transporter permease 1360014 1212712 SAV_1078 Streptomyces avermitilis MA-4680 ABC transporter permease NP_822253.1 1359193 R 227882 CDS NP_822254.1 29827620 1212713 complement(1360116..1361069) 1 NC_003155.4 ABC transporter permease 1361069 1212713 SAV_1079 Streptomyces avermitilis MA-4680 ABC transporter permease NP_822254.1 1360116 R 227882 CDS NP_822255.1 29827621 1212714 complement(1361096..1362439) 1 NC_003155.4 ABC transporter substrate-binding protein 1362439 1212714 SAV_1080 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_822255.1 1361096 R 227882 CDS NP_822256.1 29827622 1212715 complement(1362458..1363636) 1 NC_003155.4 transcriptional regulator 1363636 1212715 SAV_1081 Streptomyces avermitilis MA-4680 transcriptional regulator NP_822256.1 1362458 R 227882 CDS NP_822257.1 29827623 1210137 1363816..1365948 1 NC_003155.4 alpha-galactosidase 1365948 agaB1 1210137 agaB1 Streptomyces avermitilis MA-4680 alpha-galactosidase NP_822257.1 1363816 D 227882 CDS NP_822258.1 29827624 1212716 complement(1366037..1366684) 1 NC_003155.4 protein 1366684 1212716 SAV_1083 Streptomyces avermitilis MA-4680 protein NP_822258.1 1366037 R 227882 CDS NP_822259.1 29827625 1212717 1367063..1367647 1 NC_003155.4 hypothetical protein 1367647 1212717 SAV_1084 Streptomyces avermitilis MA-4680 hypothetical protein NP_822259.1 1367063 D 227882 CDS NP_822260.1 29827626 1212718 1368024..1372298 1 NC_003155.4 two-component system sensor kinase 1372298 1212718 SAV_1085 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_822260.1 1368024 D 227882 CDS NP_822261.1 29827627 1212719 1372393..1374891 1 NC_003155.4 PF03861: ANTAR domain; magnesium or manganese-dependent protein phosphatase 1374891 prpF 1212719 prpF Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_822261.1 1372393 D 227882 CDS NP_822262.1 29827628 1210138 1375028..1375915 1 NC_003155.4 RNA polymerase alternative sigma factor; RNA polymerase sigma factor 1375915 sig14 1210138 sig14 Streptomyces avermitilis MA-4680 RNA polymerase sigma factor NP_822262.1 1375028 D 227882 CDS NP_822263.1 29827629 1212720 complement(1375979..1376152) 1 NC_003155.4 PF05532: CsbD-like; hypothetical protein 1376152 1212720 SAV_1088 Streptomyces avermitilis MA-4680 hypothetical protein NP_822263.1 1375979 R 227882 CDS NP_822264.1 29827630 1212721 complement(1376258..1376590) 1 NC_003155.4 hypothetical protein 1376590 1212721 SAV_1089 Streptomyces avermitilis MA-4680 hypothetical protein NP_822264.1 1376258 R 227882 CDS NP_822265.1 29827631 1212722 complement(1376875..1377075) 1 NC_003155.4 hypothetical protein 1377075 1212722 SAV_1090 Streptomyces avermitilis MA-4680 hypothetical protein NP_822265.1 1376875 R 227882 CDS NP_822266.1 29827632 1212723 1377301..1377678 1 NC_003155.4 PF01740: STAS domain; anti-sigma factor antagonist 1377678 1212723 SAV_1091 Streptomyces avermitilis MA-4680 anti-sigma factor antagonist NP_822266.1 1377301 D 227882 CDS NP_822267.1 29827633 1212724 complement(1377924..1378400) 1 NC_003155.4 MarR family transcriptional regulator 1378400 1212724 SAV_1092 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_822267.1 1377924 R 227882 CDS NP_822268.1 29827634 1212725 1378554..1379741 1 NC_003155.4 PF01590: GAF domain; magnesium or manganese-dependent protein phosphatase 1379741 prpB3 1212725 prpB3 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_822268.1 1378554 D 227882 CDS NP_822269.1 29827635 1210139 1379931..1380830 1 NC_003155.4 positive regulator 1380830 rsbR 1210139 rsbR Streptomyces avermitilis MA-4680 positive regulator NP_822269.1 1379931 D 227882 CDS NP_822270.1 29827636 1210140 1380827..1381246 1 NC_003155.4 PF01740: STAS domain; anti-sigma factor antagonist 1381246 rsbS 1210140 rsbS Streptomyces avermitilis MA-4680 anti-sigma factor antagonist NP_822270.1 1380827 D 227882 CDS NP_822271.1 29827637 1210141 1381294..1381689 1 NC_003155.4 PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; anti-sigma factor 1381689 rsbT 1210141 rsbT Streptomyces avermitilis MA-4680 anti-sigma factor NP_822271.1 1381294 D 227882 CDS NP_822272.1 29827638 1212726 1381686..1382759 1 NC_003155.4 PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; magnesium or manganese-dependent protein phosphatase 1382759 prpI2 1212726 prpI2 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_822272.1 1381686 D 227882 CDS NP_822273.1 29827639 1212727 1382756..1384498 1 NC_003155.4 PF01590: GAF domain; magnesium or manganese-dependent protein phosphatase 1384498 prpB4 1212727 prpB4 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_822273.1 1382756 D 227882 CDS NP_822274.1 29827640 1212728 complement(1384489..1384995) 1 NC_003155.4 MarR family transcriptional regulator 1384995 1212728 SAV_1099 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_822274.1 1384489 R 227882 CDS NP_822275.1 29827641 1212729 1385447..1385881 1 NC_003155.4 regulatory protein 1385881 1212729 SAV_1100 Streptomyces avermitilis MA-4680 regulatory protein NP_822275.1 1385447 D 227882 CDS NP_822276.1 29827642 1212730 complement(1386020..1386520) 1 NC_003155.4 hypothetical protein 1386520 1212730 SAV_1101 Streptomyces avermitilis MA-4680 hypothetical protein NP_822276.1 1386020 R 227882 CDS NP_822277.1 29827643 1212731 complement(1386577..1386972) 1 NC_003155.4 PF01740: STAS domain; anti-sigma factor antagonist 1386972 1212731 SAV_1102 Streptomyces avermitilis MA-4680 anti-sigma factor antagonist NP_822277.1 1386577 R 227882 CDS NP_822278.1 29827644 1212732 complement(1387458..1387943) 1 NC_003155.4 regulatory protein 1387943 1212732 SAV_1103 Streptomyces avermitilis MA-4680 regulatory protein NP_822278.1 1387458 R 227882 CDS NP_822279.1 29827645 1210142 1388246..1390171 1 NC_003155.4 PF00501: AMP-binding enzyme; acyl-CoA synthetase, long-chain fatty acid:CoA ligase 1390171 fadD3 1210142 fadD3 Streptomyces avermitilis MA-4680 acyl-CoA synthetase, long-chain fatty acid:CoA ligase NP_822279.1 1388246 D 227882 CDS NP_822280.1 29827646 1212733 complement(1390246..1390983) 1 NC_003155.4 hypothetical protein 1390983 1212733 SAV_1105 Streptomyces avermitilis MA-4680 hypothetical protein NP_822280.1 1390246 R 227882 CDS NP_822281.1 29827647 1212734 complement(1391231..1392991) 1 NC_003155.4 PF02163: Peptidase family M50; hypothetical protein 1392991 1212734 SAV_1106 Streptomyces avermitilis MA-4680 hypothetical protein NP_822281.1 1391231 R 227882 CDS NP_822282.1 29827648 1212735 complement(1393073..1393315) 1 NC_003155.4 hypothetical protein 1393315 1212735 SAV_1107 Streptomyces avermitilis MA-4680 hypothetical protein NP_822282.1 1393073 R 227882 CDS NP_822283.1 29827649 1212736 complement(1393534..1393842) 1 NC_003155.4 hypothetical protein 1393842 1212736 SAV_1108 Streptomyces avermitilis MA-4680 hypothetical protein NP_822283.1 1393534 R 227882 CDS NP_822284.1 29827650 1212737 1393981..1394376 1 NC_003155.4 hypothetical protein 1394376 1212737 SAV_1109 Streptomyces avermitilis MA-4680 hypothetical protein NP_822284.1 1393981 D 227882 CDS NP_822285.1 29827651 1212738 1394582..1394878 1 NC_003155.4 hypothetical protein 1394878 1212738 SAV_1110 Streptomyces avermitilis MA-4680 hypothetical protein NP_822285.1 1394582 D 227882 CDS NP_822286.1 29827652 1212739 complement(1395202..1396032) 1 NC_003155.4 PF04951: D-aminopeptidase; D-aminopeptidase 1396032 1212739 SAV_1111 Streptomyces avermitilis MA-4680 D-aminopeptidase NP_822286.1 1395202 R 227882 CDS NP_822287.1 29827653 1212740 1396223..1397143 1 NC_003155.4 PF02668: Taurine catabolism dioxygenase TauD, TfdA family; taurine catabolism dioxygenase 1397143 1212740 SAV_1112 Streptomyces avermitilis MA-4680 taurine catabolism dioxygenase NP_822287.1 1396223 D 227882 CDS NP_822288.1 29827654 1212741 complement(1397147..1397677) 1 NC_003155.4 hypothetical protein 1397677 1212741 SAV_1113 Streptomyces avermitilis MA-4680 hypothetical protein NP_822288.1 1397147 R 227882 CDS NP_822289.1 29827655 1212742 1397751..1398434 1 NC_003155.4 hypothetical protein 1398434 1212742 SAV_1114 Streptomyces avermitilis MA-4680 hypothetical protein NP_822289.1 1397751 D 227882 CDS NP_822290.1 29827656 1212743 1398758..1400167 1 NC_003155.4 arabinofuranosidase 1400167 1212743 SAV_1115 Streptomyces avermitilis MA-4680 arabinofuranosidase NP_822290.1 1398758 D 227882 CDS NP_822291.1 29827657 1212744 1400293..1402032 1 NC_003155.4 PF02366: Dolichyl-phosphate-mannose-protein mannosyltransferase; hypothetical protein 1402032 1212744 SAV_1116 Streptomyces avermitilis MA-4680 hypothetical protein NP_822291.1 1400293 D 227882 CDS NP_822292.1 29827658 1212745 complement(1402053..1403417) 1 NC_003155.4 PF01433: Peptidase family M1; metallopeptidase 1403417 1212745 SAV_1117 Streptomyces avermitilis MA-4680 metallopeptidase NP_822292.1 1402053 R 227882 CDS NP_822293.1 29827659 1212746 1403619..1403963 1 NC_003155.4 hypothetical protein 1403963 1212746 SAV_1118 Streptomyces avermitilis MA-4680 hypothetical protein NP_822293.1 1403619 D 227882 CDS NP_822294.1 29827660 1212747 complement(1404364..1405710) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; membrane transport protein 1405710 1212747 SAV_1119 Streptomyces avermitilis MA-4680 membrane transport protein NP_822294.1 1404364 R 227882 CDS NP_822295.1 29827661 1212748 complement(1405778..1406389) 1 NC_003155.4 PF01810: LysE type translocator; hypothetical protein 1406389 1212748 SAV_1120 Streptomyces avermitilis MA-4680 hypothetical protein NP_822295.1 1405778 R 227882 CDS NP_822296.1 29827662 1212749 1406456..1407412 1 NC_003155.4 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 1407412 1212749 SAV_1121 Streptomyces avermitilis MA-4680 chromosome replication initiation inhibitor protein NP_822296.1 1406456 D 227882 CDS NP_822297.1 29827663 1212750 1407714..1409957 1 NC_003155.4 hypothetical protein 1409957 1212750 SAV_1122 Streptomyces avermitilis MA-4680 hypothetical protein NP_822297.1 1407714 D 227882 CDS NP_822298.1 29827664 1212751 1409996..1410571 1 NC_003155.4 hypothetical protein 1410571 1212751 SAV_1123 Streptomyces avermitilis MA-4680 hypothetical protein NP_822298.1 1409996 D 227882 CDS NP_822299.1 29827665 1212752 complement(1410593..1411429) 1 NC_003155.4 PF02743: Cache domain; hypothetical protein 1411429 1212752 SAV_1124 Streptomyces avermitilis MA-4680 hypothetical protein NP_822299.1 1410593 R 227882 CDS NP_822300.1 29827666 1212753 1411647..1412945 1 NC_003155.4 ABC transporter 1412945 1212753 SAV_1125 Streptomyces avermitilis MA-4680 ABC transporter NP_822300.1 1411647 D 227882 CDS NP_822301.1 29827667 1210143 complement(1412969..1414465) 1 NC_003155.4 xylulose kinase 1414465 xylB2 1210143 xylB2 Streptomyces avermitilis MA-4680 xylulose kinase NP_822301.1 1412969 R 227882 CDS NP_822302.1 29827668 1212754 1414635..1415312 1 NC_003155.4 PF01987: Protein of unknown function DUF124; hypothetical protein 1415312 1212754 SAV_1127 Streptomyces avermitilis MA-4680 hypothetical protein NP_822302.1 1414635 D 227882 CDS NP_822303.1 29827669 1212755 complement(1415378..1417162) 1 NC_003155.4 PF02868: Thermolysin metallopeptidase, alpha-helical domain; neutral zinc metalloprotease 1417162 1212755 SAV_1128 Streptomyces avermitilis MA-4680 neutral zinc metalloprotease NP_822303.1 1415378 R 227882 CDS NP_822304.1 29827670 1210144 complement(1417491..1418525) 1 NC_003155.4 probably farnesyl pyrophosphate synthase; polyprenyl diphosphate synthase 1418525 idsA1 1210144 idsA1 Streptomyces avermitilis MA-4680 polyprenyl diphosphate synthase NP_822304.1 1417491 R 227882 CDS NP_822305.1 29827671 1212756 complement(1418522..1419580) 1 NC_003155.4 PF00515: TPR Domain; hypothetical protein 1419580 1212756 SAV_1130 Streptomyces avermitilis MA-4680 hypothetical protein NP_822305.1 1418522 R 227882 CDS NP_822306.1 29827672 1212757 1419909..1420535 1 NC_003155.4 alkylated DNA repair protein 1420535 1212757 SAV_1131 Streptomyces avermitilis MA-4680 alkylated DNA repair protein NP_822306.1 1419909 D 227882 CDS NP_822307.1 29827673 1212758 complement(1420548..1421135) 1 NC_003155.4 TetR family transcriptional regulator 1421135 1212758 SAV_1132 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_822307.1 1420548 R 227882 CDS NP_822308.1 29827674 1212759 complement(1421141..1422697) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; membrane transport protein 1422697 1212759 SAV_1133 Streptomyces avermitilis MA-4680 membrane transport protein NP_822308.1 1421141 R 227882 CDS NP_822309.1 29827675 1212760 complement(1422761..1423966) 1 NC_003155.4 PF01360: Monooxygenase; hydroxylase 1423966 1212760 SAV_1134 Streptomyces avermitilis MA-4680 hydroxylase NP_822309.1 1422761 R 227882 CDS NP_822310.1 29827676 1212761 1424120..1424587 1 NC_003155.4 hypothetical protein 1424587 1212761 SAV_1135 Streptomyces avermitilis MA-4680 hypothetical protein NP_822310.1 1424120 D 227882 CDS NP_822311.1 29827677 1210145 1424869..1425225 1 NC_003155.4 melanin biosynthesis; tyrosinase co-factor protein 1425225 melC2 1210145 melC2 Streptomyces avermitilis MA-4680 tyrosinase co-factor protein NP_822311.1 1424869 D 227882 CDS NP_822312.1 29827678 1210146 1425261..1426085 1 NC_003155.4 melanin biosynthesis; tyrosinase 1426085 melC1 1210146 melC1 Streptomyces avermitilis MA-4680 tyrosinase NP_822312.1 1425261 D 227882 CDS NP_822313.1 29827679 1212762 complement(1426227..1426937) 1 NC_003155.4 PF00075: RNase H; ribonuclease H 1426937 rnhA 1212762 rnhA Streptomyces avermitilis MA-4680 ribonuclease H NP_822313.1 1426227 R 227882 CDS NP_822314.1 29827680 1212763 1427146..1427637 1 NC_003155.4 PF01047: MarR family; hypothetical protein 1427637 1212763 SAV_1139 Streptomyces avermitilis MA-4680 hypothetical protein NP_822314.1 1427146 D 227882 CDS NP_822315.1 29827681 1212764 complement(1427717..1428514) 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hydroxylase 1428514 1212764 SAV_1140 Streptomyces avermitilis MA-4680 hydroxylase NP_822315.1 1427717 R 227882 CDS NP_822316.1 29827682 1212765 1428660..1429664 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; alcohol dehydrogenase 1429664 adhA1 1212765 adhA1 Streptomyces avermitilis MA-4680 alcohol dehydrogenase NP_822316.1 1428660 D 227882 CDS NP_822317.1 29827683 1212766 1429684..1430985 1 NC_003155.4 PF01590: GAF domain; magnesium or manganese-dependent protein phosphatase 1430985 prpB5 1212766 prpB5 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_822317.1 1429684 D 227882 CDS NP_822318.1 29827684 1212767 1431142..1432050 1 NC_003155.4 hypothetical protein 1432050 1212767 SAV_1143 Streptomyces avermitilis MA-4680 hypothetical protein NP_822318.1 1431142 D 227882 CDS NP_822319.1 29827685 1212768 1432284..1434848 1 NC_003155.4 PF02210: Laminin G domain; protein 1434848 1212768 SAV_1144 Streptomyces avermitilis MA-4680 protein NP_822319.1 1432284 D 227882 CDS NP_822320.1 29827686 1212769 complement(1434873..1435355) 1 NC_003155.4 DNA-binding protein 1435355 1212769 SAV_1145 Streptomyces avermitilis MA-4680 DNA-binding protein NP_822320.1 1434873 R 227882 CDS NP_822321.1 29827687 1212770 1435653..1436306 1 NC_003155.4 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 1436306 clpP4 1212770 clpP4 Streptomyces avermitilis MA-4680 ATP-dependent Clp protease proteolytic subunit NP_822321.1 1435653 D 227882 CDS NP_822322.1 29827688 1212771 1436308..1436910 1 NC_003155.4 PF00574: Clp protease; ATP-dependent Clp protease proteolytic subunit 2 1436910 clpP5 1212771 clpP5 Streptomyces avermitilis MA-4680 ATP-dependent Clp protease proteolytic subunit 2 NP_822322.1 1436308 D 227882 CDS NP_822323.1 29827689 1212772 complement(1437000..1437455) 1 NC_003155.4 DNA-binding protein 1437455 1212772 SAV_1148 Streptomyces avermitilis MA-4680 DNA-binding protein NP_822323.1 1437000 R 227882 CDS NP_822324.1 29827690 1212773 1437699..1439168 1 NC_003155.4 PF01839: FG-GAP repeat; esterase 1439168 1212773 SAV_1149 Streptomyces avermitilis MA-4680 esterase NP_822324.1 1437699 D 227882 CDS NP_822325.1 29827691 1212774 1439316..1439543 1 NC_003155.4 hypothetical protein 1439543 1212774 SAV_1150 Streptomyces avermitilis MA-4680 hypothetical protein NP_822325.1 1439316 D 227882 CDS NP_822326.1 29827692 1210147 1439664..1440551 1 NC_003155.4 RNA polymerase alternative sigma factor; RNA polymerase sigma factor 1440551 sig15 1210147 sig15 Streptomyces avermitilis MA-4680 RNA polymerase sigma factor NP_822326.1 1439664 D 227882 CDS NP_822327.1 29827693 1212775 complement(1440671..1442164) 1 NC_003155.4 PF00781: Diacylglycerol kinase catalytic domain (presumed); hypothetical protein 1442164 1212775 SAV_1152 Streptomyces avermitilis MA-4680 hypothetical protein NP_822327.1 1440671 R 227882 CDS NP_822328.1 29827694 1212776 complement(1442225..1442683) 1 NC_003155.4 regulatory protein 1442683 1212776 SAV_1153 Streptomyces avermitilis MA-4680 regulatory protein NP_822328.1 1442225 R 227882 CDS NP_822329.1 29827695 1212777 complement(1442897..1444327) 1 NC_003155.4 hypothetical protein 1444327 1212777 SAV_1154 Streptomyces avermitilis MA-4680 hypothetical protein NP_822329.1 1442897 R 227882 CDS NP_822330.1 29827696 1212778 1444480..1445736 1 NC_003155.4 hypothetical protein 1445736 1212778 SAV_1155 Streptomyces avermitilis MA-4680 hypothetical protein NP_822330.1 1444480 D 227882 CDS NP_822331.1 29827697 1212779 1445834..1446853 1 NC_003155.4 PF00296: Luciferase-like monooxygenase; monooxygenase 1446853 1212779 SAV_1156 Streptomyces avermitilis MA-4680 monooxygenase NP_822331.1 1445834 D 227882 CDS NP_822332.1 29827698 1210148 complement(1446863..1447837) 1 NC_003155.4 serine/threonine protein kinase 1447837 pkn3 1210148 pkn3 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_822332.1 1446863 R 227882 CDS NP_822333.1 29827699 1212780 complement(1447837..1448433) 1 NC_003155.4 hypothetical protein 1448433 1212780 SAV_1158 Streptomyces avermitilis MA-4680 hypothetical protein NP_822333.1 1447837 R 227882 CDS NP_822334.1 29827700 1212781 complement(1448439..1450781) 1 NC_003155.4 ABC transporter ATP-binding protein 1450781 1212781 SAV_1159 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_822334.1 1448439 R 227882 CDS NP_822335.1 29827701 1212782 complement(1450848..1451258) 1 NC_003155.4 hypothetical protein 1451258 1212782 SAV_1160 Streptomyces avermitilis MA-4680 hypothetical protein NP_822335.1 1450848 R 227882 CDS NP_822336.1 29827702 1212783 1451671..1452057 1 NC_003155.4 isomerase 1452057 1212783 SAV_1161 Streptomyces avermitilis MA-4680 isomerase NP_822336.1 1451671 D 227882 CDS NP_822337.1 29827703 1212784 complement(1452141..1453103) 1 NC_003155.4 PF00248: Aldo/keto reductase family; ion channel subunit 1453103 1212784 SAV_1162 Streptomyces avermitilis MA-4680 ion channel subunit NP_822337.1 1452141 R 227882 CDS NP_822338.1 29827704 1212785 1453280..1454158 1 NC_003155.4 LysR family transcriptional regulator 1454158 1212785 SAV_1163 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_822338.1 1453280 D 227882 CDS NP_822339.1 29827705 1212786 1454314..1454829 1 NC_003155.4 hypothetical protein 1454829 1212786 SAV_1164 Streptomyces avermitilis MA-4680 hypothetical protein NP_822339.1 1454314 D 227882 CDS NP_822340.1 29827706 1210149 complement(1454811..1455875) 1 NC_003155.4 catalyzes the formation of inosine from adenosine; adenosine deaminase 1455875 add1 1210149 add1 Streptomyces avermitilis MA-4680 adenosine deaminase NP_822340.1 1454811 R 227882 CDS NP_822341.1 29827707 1212787 complement(1455900..1456307) 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein 1456307 1212787 SAV_1166 Streptomyces avermitilis MA-4680 hypothetical protein NP_822341.1 1455900 R 227882 CDS NP_822342.1 29827708 1212788 complement(1456484..1457401) 1 NC_003155.4 PF01435: Peptidase family M48; hypothetical protein 1457401 1212788 SAV_1167 Streptomyces avermitilis MA-4680 hypothetical protein NP_822342.1 1456484 R 227882 CDS NP_822343.1 29827709 1212789 complement(1457398..1457769) 1 NC_003155.4 PF01047: MarR family; hypothetical protein 1457769 1212789 SAV_1168 Streptomyces avermitilis MA-4680 hypothetical protein NP_822343.1 1457398 R 227882 CDS NP_822344.1 29827710 1212790 1457969..1458820 1 NC_003155.4 PF01569: PAP2 superfamily; hypothetical protein 1458820 1212790 SAV_1169 Streptomyces avermitilis MA-4680 hypothetical protein NP_822344.1 1457969 D 227882 CDS NP_822345.1 29827711 1212791 1458666..1459718 1 NC_003155.4 PF01758: Sodium Bile acid symporter family; sodium-dependent transporter 1459718 1212791 SAV_1170 Streptomyces avermitilis MA-4680 sodium-dependent transporter NP_822345.1 1458666 D 227882 CDS NP_822346.1 29827712 1210150 complement(1460052..1461257) 1 NC_003155.4 CYP107F2; cytochrome P450 1461257 cyp5 1210150 cyp5 Streptomyces avermitilis MA-4680 cytochrome P450 NP_822346.1 1460052 R 227882 CDS NP_822347.1 29827713 1212792 complement(1461860..1462783) 1 NC_003155.4 PF00248: Aldo/keto reductase family; oxidoreductase 1462783 1212792 SAV_1172 Streptomyces avermitilis MA-4680 oxidoreductase NP_822347.1 1461860 R 227882 CDS NP_822348.1 29827714 1212793 complement(1462809..1464203) 1 NC_003155.4 hypothetical protein 1464203 1212793 SAV_1173 Streptomyces avermitilis MA-4680 hypothetical protein NP_822348.1 1462809 R 227882 CDS NP_822349.1 29827715 1212794 1464641..1465246 1 NC_003155.4 hypothetical protein 1465246 1212794 SAV_1174 Streptomyces avermitilis MA-4680 hypothetical protein NP_822349.1 1464641 D 227882 CDS NP_822350.1 29827716 1212795 complement(1465703..1466494) 1 NC_003155.4 hypothetical protein 1466494 1212795 SAV_1175 Streptomyces avermitilis MA-4680 hypothetical protein NP_822350.1 1465703 R 227882 CDS NP_822351.1 29827717 1212796 complement(1466669..1466827) 1 NC_003155.4 hypothetical protein 1466827 1212796 SAV_1176 Streptomyces avermitilis MA-4680 hypothetical protein NP_822351.1 1466669 R 227882 CDS NP_822352.1 29827718 1212797 complement(1466876..1468402) 1 NC_003155.4 Activates fatty acids by binding to coenzyme A; acyl-CoA synthase 1468402 1212797 SAV_1177 Streptomyces avermitilis MA-4680 acyl-CoA synthase NP_822352.1 1466876 R 227882 CDS NP_822353.1 29827719 1210151 complement(1468399..1470597) 1 NC_003155.4 similar to Streptomyces griseus pabAB; para-aminobenzoic acid synthase 1470597 pabAB 1210151 pabAB Streptomyces avermitilis MA-4680 para-aminobenzoic acid synthase NP_822353.1 1468399 R 227882 CDS NP_822354.1 29827720 1212798 complement(1470594..1471157) 1 NC_003155.4 hypothetical protein 1471157 1212798 SAV_1179 Streptomyces avermitilis MA-4680 hypothetical protein NP_822354.1 1470594 R 227882 CDS NP_822355.1 29827721 1212799 1471456..1473141 1 NC_003155.4 PF05547: Immune inhibitor A peptidase M6; protease 1473141 1212799 SAV_1180 Streptomyces avermitilis MA-4680 protease NP_822355.1 1471456 D 227882 CDS NP_822356.1 29827722 1212800 1473145..1473453 1 NC_003155.4 hypothetical protein 1473453 1212800 SAV_1181 Streptomyces avermitilis MA-4680 hypothetical protein NP_822356.1 1473145 D 227882 CDS NP_822357.1 29827723 1212801 1473954..1474355 1 NC_003155.4 hypothetical protein 1474355 1212801 SAV_1182 Streptomyces avermitilis MA-4680 hypothetical protein NP_822357.1 1473954 D 227882 CDS NP_822358.1 29827724 1212802 complement(1474359..1474949) 1 NC_003155.4 PF04264: YceI like family; hypothetical protein 1474949 1212802 SAV_1183 Streptomyces avermitilis MA-4680 hypothetical protein NP_822358.1 1474359 R 227882 CDS NP_822359.1 29827725 1212803 1475033..1475533 1 NC_003155.4 MarR family transcriptional regulator 1475533 1212803 SAV_1184 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_822359.1 1475033 D 227882 CDS NP_822360.1 29827726 1212804 complement(1475897..1476667) 1 NC_003155.4 LysR family trancsriptional regulator 1476667 1212804 SAV_1185 Streptomyces avermitilis MA-4680 LysR family trancsriptional regulator NP_822360.1 1475897 R 227882 CDS NP_822361.1 29827727 1212805 1476726..1477133 1 NC_003155.4 hypothetical protein 1477133 1212805 SAV_1186 Streptomyces avermitilis MA-4680 hypothetical protein NP_822361.1 1476726 D 227882 CDS NP_822362.1 29827728 1210152 complement(1477301..1478626) 1 NC_003155.4 PF00171: Aldehyde dehydrogenase family; aldehyde dehydrogenase 1478626 aldH 1210152 aldH Streptomyces avermitilis MA-4680 aldehyde dehydrogenase NP_822362.1 1477301 R 227882 CDS NP_822363.1 29827729 1212806 complement(1478786..1479250) 1 NC_003155.4 MarR family transcriptional regulator 1479250 amiA 1212806 amiA Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_822363.1 1478786 R 227882 CDS NP_822364.1 29827730 1212807 1479316..1480428 1 NC_003155.4 regulatory protein 1480428 1212807 SAV_1189 Streptomyces avermitilis MA-4680 regulatory protein NP_822364.1 1479316 D 227882 CDS NP_822365.1 29827731 1212808 1480655..1481956 1 NC_003155.4 ABC transporter substrate-binding protein 1481956 1212808 SAV_1190 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_822365.1 1480655 D 227882 CDS NP_822366.1 29827732 1212809 1482024..1482920 1 NC_003155.4 branched-chain amino acid ABC transporter permease 1482920 1212809 SAV_1191 Streptomyces avermitilis MA-4680 branched-chain amino acid ABC transporter permease NP_822366.1 1482024 D 227882 CDS NP_822367.1 29827733 1212810 1482917..1484026 1 NC_003155.4 branched-chain amino acid ABC transporter permease 1484026 1212810 SAV_1192 Streptomyces avermitilis MA-4680 branched-chain amino acid ABC transporter permease NP_822367.1 1482917 D 227882 CDS NP_822368.1 29827734 1212811 1484023..1484829 1 NC_003155.4 ABC transporter ATP-binding protein 1484829 1212811 SAV_1193 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_822368.1 1484023 D 227882 CDS NP_822369.1 29827735 1212812 1484829..1485521 1 NC_003155.4 ABC transporter ATP-binding protein 1485521 1212812 SAV_1194 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_822369.1 1484829 D 227882 CDS NP_822370.1 29827736 1210153 complement(1485526..1486716) 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 1486716 sig16 1210153 sig16 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_822370.1 1485526 R 227882 CDS NP_822371.1 29827737 1212813 complement(1486716..1487108) 1 NC_003155.4 PF04946: DGPF domain; hypothetical protein 1487108 1212813 SAV_1196 Streptomyces avermitilis MA-4680 hypothetical protein NP_822371.1 1486716 R 227882 CDS NP_822372.1 29827738 1212814 1487174..1488235 1 NC_003155.4 PF02771: Acyl-CoA dehydrogenase, N-terminal domain; hypothetical protein 1488235 1212814 SAV_1197 Streptomyces avermitilis MA-4680 hypothetical protein NP_822372.1 1487174 D 227882 CDS NP_822373.1 29827739 1212815 1488724..1488921 1 NC_003155.4 IS630 family, partial; IS630 family transposase 1488921 1212815 SAV_1198 Streptomyces avermitilis MA-4680 IS630 family transposase NP_822373.1 1488724 D 227882 CDS NP_822374.1 29827740 1212816 complement(1488976..1490019) 1 NC_003155.4 AraC family transcription regulator 1490019 1212816 SAV_1199 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_822374.1 1488976 R 227882 CDS NP_822375.1 29827741 1212817 1490156..1491082 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 1491082 1212817 SAV_1200 Streptomyces avermitilis MA-4680 dehydrogenase NP_822375.1 1490156 D 227882 CDS NP_822376.1 29827742 1212818 1491478..1492473 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 1492473 1212818 SAV_1201 Streptomyces avermitilis MA-4680 dehydrogenase NP_822376.1 1491478 D 227882 CDS NP_822377.1 29827743 1212819 1492522..1493124 1 NC_003155.4 TetR family transcriptional regulator 1493124 1212819 SAV_1202 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_822377.1 1492522 D 227882 CDS NP_822378.1 29827744 1212820 complement(1493561..1493815) 1 NC_003155.4 hypothetical protein 1493815 1212820 SAV_1203 Streptomyces avermitilis MA-4680 hypothetical protein NP_822378.1 1493561 R 227882 CDS NP_822379.2 57833857 1212821 complement(1493973..1495142) 1 NC_003155.4 IS630 family transposase 1495142 1212821 SAV_1204 Streptomyces avermitilis MA-4680 IS630 family transposase NP_822379.2 1493973 R 227882 CDS NP_822380.1 29827746 1212822 complement(1495178..1496359) 1 NC_003155.4 PF00296: Luciferase-like monooxygenase; alkanesulfonate monooxygenase 1496359 ssuD1 1212822 ssuD1 Streptomyces avermitilis MA-4680 alkanesulfonate monooxygenase NP_822380.1 1495178 R 227882 CDS NP_822381.1 29827747 1212823 complement(1496417..1497601) 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 1497601 1212823 SAV_1206 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_822381.1 1496417 R 227882 CDS NP_822382.1 29827748 1212824 complement(1497607..1498161) 1 NC_003155.4 PF03358: NADPH-dependent FMN reductase; NAD(P)H-dependent FMN reductase 1498161 1212824 SAV_1207 Streptomyces avermitilis MA-4680 NAD(P)H-dependent FMN reductase NP_822382.1 1497607 R 227882 CDS NP_822383.1 29827749 1212825 complement(1498327..1499448) 1 NC_003155.4 PF00296: Luciferase-like monooxygenase; monooxygenase 1499448 1212825 SAV_1208 Streptomyces avermitilis MA-4680 monooxygenase NP_822383.1 1498327 R 227882 CDS NP_822384.1 29827750 1212826 1499955..1500875 1 NC_003155.4 LysR family transcriptional regulator 1500875 1212826 SAV_1209 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_822384.1 1499955 D 227882 CDS NP_822385.1 29827751 1212827 1500906..1501055 1 NC_003155.4 hypothetical protein 1501055 1212827 SAV_1210 Streptomyces avermitilis MA-4680 hypothetical protein NP_822385.1 1500906 D 227882 CDS NP_822386.1 29827752 1212828 1501530..1503104 1 NC_003155.4 PF01073: 3-beta-hydroxysteroid dehydrogenase/isomerase family; oxidoreductase 1503104 1212828 SAV_1211 Streptomyces avermitilis MA-4680 oxidoreductase NP_822386.1 1501530 D 227882 CDS NP_822387.1 29827753 1210154 1503492..1504865 1 NC_003155.4 deoxyribodipyrimidine photolyase 1504865 phrB 1210154 phrB Streptomyces avermitilis MA-4680 deoxyribodipyrimidine photolyase NP_822387.1 1503492 D 227882 CDS NP_822388.1 29827754 1212829 complement(1504925..1506178) 1 NC_003155.4 PF01593: Flavin containing amine oxidoreductase; oxidoreductase 1506178 1212829 SAV_1213 Streptomyces avermitilis MA-4680 oxidoreductase NP_822388.1 1504925 R 227882 CDS NP_822389.1 29827755 1212830 complement(1506484..1507527) 1 NC_003155.4 probably regulates carotenoid biosynthesis; transcriptional regulator 1507527 1212830 SAV_1214 Streptomyces avermitilis MA-4680 transcriptional regulator NP_822389.1 1506484 R 227882 CDS NP_822390.1 29827756 1210155 1507710..1508324 1 NC_003155.4 probably regulates carotenoid biosynthesis; ECF subfamily RNA polymerase sigma factor 1508324 sig17 1210155 sig17 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_822390.1 1507710 D 227882 CDS NP_822391.1 29827757 1212831 1508862..1509881 1 NC_003155.4 PF03631: Ribonuclease BN-like family; ribonuclease BN family membrane protein 1509881 1212831 SAV_1216 Streptomyces avermitilis MA-4680 ribonuclease BN family membrane protein NP_822391.1 1508862 D 227882 CDS NP_822392.1 29827758 1210156 complement(1509820..1510692) 1 NC_003155.4 PF00753: Metallo-beta-lactamase superfamily; metallo-beta-lactamase 1510692 blaB2 1210156 blaB2 Streptomyces avermitilis MA-4680 metallo-beta-lactamase NP_822392.1 1509820 R 227882 CDS NP_822393.1 29827759 1212832 1510755..1511354 1 NC_003155.4 TetR family transcriptional regulator 1511354 1212832 SAV_1218 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_822393.1 1510755 D 227882 CDS NP_822394.1 29827760 1212833 1511493..1511933 1 NC_003155.4 PF03779: SPW repeat; hypothetical protein 1511933 1212833 SAV_1219 Streptomyces avermitilis MA-4680 hypothetical protein NP_822394.1 1511493 D 227882 CDS NP_822395.1 29827761 1212834 1512151..1513404 1 NC_003155.4 PF01636: Phosphotransferase enzyme family; hypothetical protein 1513404 1212834 SAV_1220 Streptomyces avermitilis MA-4680 hypothetical protein NP_822395.1 1512151 D 227882 CDS NP_822396.1 29827762 1212835 complement(1513650..1515119) 1 NC_003155.4 amino acid permease 1515119 1212835 SAV_1221 Streptomyces avermitilis MA-4680 amino acid permease NP_822396.1 1513650 R 227882 CDS NP_822397.1 29827763 1212836 1515303..1516502 1 NC_003155.4 transcriptional regulator 1516502 1212836 SAV_1222 Streptomyces avermitilis MA-4680 transcriptional regulator NP_822397.1 1515303 D 227882 CDS NP_822398.1 29827764 1212837 1516617..1519331 1 NC_003155.4 beta-mannosidase 1519331 1212837 SAV_1223 Streptomyces avermitilis MA-4680 beta-mannosidase NP_822398.1 1516617 D 227882 CDS NP_822399.1 29827765 1212838 complement(1519410..1520858) 1 NC_003155.4 hydrolase 1520858 1212838 SAV_1224 Streptomyces avermitilis MA-4680 hydrolase NP_822399.1 1519410 R 227882 CDS NP_822400.1 29827766 1212839 1521090..1521353 1 NC_003155.4 transglycosylase associated protein 1521353 1212839 SAV_1225 Streptomyces avermitilis MA-4680 transglycosylase associated protein NP_822400.1 1521090 D 227882 CDS NP_822401.1 29827767 1212840 1521511..1522497 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 1522497 1212840 SAV_1226 Streptomyces avermitilis MA-4680 acetyltransferase NP_822401.1 1521511 D 227882 CDS NP_822402.1 29827768 1212841 complement(1522627..1523400) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 1523400 1212841 SAV_1227 Streptomyces avermitilis MA-4680 acetyltransferase NP_822402.1 1522627 R 227882 CDS NP_822403.1 29827769 1212842 1523648..1524178 1 NC_003155.4 possible transporter; hypothetical protein 1524178 1212842 SAV_1228 Streptomyces avermitilis MA-4680 hypothetical protein NP_822403.1 1523648 D 227882 CDS NP_822404.1 29827770 1212843 complement(1524392..1525243) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 1525243 1212843 SAV_1229 Streptomyces avermitilis MA-4680 acetyltransferase NP_822404.1 1524392 R 227882 CDS NP_822405.1 29827771 1212844 complement(1525501..1526181) 1 NC_003155.4 PF03777: Small domain (DUF320); protein 1526181 1212844 SAV_1230 Streptomyces avermitilis MA-4680 protein NP_822405.1 1525501 R 227882 CDS NP_822406.1 29827772 1212845 1526437..1528074 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; protease 1528074 1212845 SAV_1231 Streptomyces avermitilis MA-4680 protease NP_822406.1 1526437 D 227882 CDS NP_822407.1 29827773 1210157 1528178..1529773 1 NC_003155.4 glutamate synthase(ferredoxin) 1529773 yerD2 1210157 yerD2 Streptomyces avermitilis MA-4680 glutamate synthase(ferredoxin) NP_822407.1 1528178 D 227882 CDS NP_822408.1 29827774 1212846 1529952..1531049 1 NC_003155.4 PF03465: eRF1 domain 3; hypothetical protein 1531049 1212846 SAV_1233 Streptomyces avermitilis MA-4680 hypothetical protein NP_822408.1 1529952 D 227882 CDS NP_822409.1 29827775 1210158 1531131..1532162 1 NC_003155.4 inositol metabolism, PF01408: Oxidoreductase family, NAD-binding Rossmann fold; myo-inositol 2-dehydrogenase 1532162 iolG 1210158 iolG Streptomyces avermitilis MA-4680 myo-inositol 2-dehydrogenase NP_822409.1 1531131 D 227882 CDS NP_822410.1 29827776 1212847 1532453..1533922 1 NC_003155.4 PF00785: PAC motif; magnesium or manganese-dependent protein phosphatase 1533922 prpC5 1212847 prpC5 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_822410.1 1532453 D 227882 CDS NP_822411.1 29827777 1212848 complement(1534044..1535540) 1 NC_003155.4 regulatory protein 1535540 1212848 SAV_1236 Streptomyces avermitilis MA-4680 regulatory protein NP_822411.1 1534044 R 227882 CDS NP_822412.1 29827778 1212849 1535774..1536916 1 NC_003155.4 PF01636: Phosphotransferase enzyme family; hypothetical protein 1536916 1212849 SAV_1237 Streptomyces avermitilis MA-4680 hypothetical protein NP_822412.1 1535774 D 227882 CDS NP_822413.1 29827779 1212850 1537201..1539180 1 NC_003155.4 amidase 1539180 1212850 SAV_1238 Streptomyces avermitilis MA-4680 amidase NP_822413.1 1537201 D 227882 CDS NP_822414.1 29827780 1212851 complement(1539243..1539740) 1 NC_003155.4 hypothetical protein 1539740 1212851 SAV_1239 Streptomyces avermitilis MA-4680 hypothetical protein NP_822414.1 1539243 R 227882 CDS NP_822415.1 29827781 1212852 1540024..1540284 1 NC_003155.4 hypothetical protein 1540284 1212852 SAV_1240 Streptomyces avermitilis MA-4680 hypothetical protein NP_822415.1 1540024 D 227882 CDS NP_822416.1 29827782 1212853 complement(1540468..1540710) 1 NC_003155.4 homology to bldB, PF04149: Domain of unknown function (DUF397); hypothetical protein 1540710 1212853 SAV_1241 Streptomyces avermitilis MA-4680 hypothetical protein NP_822416.1 1540468 R 227882 CDS NP_822417.1 29827783 1212854 complement(1540794..1541960) 1 NC_003155.4 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 1541960 1212854 SAV_1242 Streptomyces avermitilis MA-4680 acetyl-CoA acetyltransferase NP_822417.1 1540794 R 227882 CDS NP_822418.1 29827784 1212855 complement(1541957..1543006) 1 NC_003155.4 lipid-transfer protein 1543006 1212855 SAV_1243 Streptomyces avermitilis MA-4680 lipid-transfer protein NP_822418.1 1541957 R 227882 CDS NP_822419.1 29827785 1212856 complement(1543003..1543923) 1 NC_003155.4 PF01796: Domain of unknown function DUF35; hypothetical protein 1543923 1212856 SAV_1244 Streptomyces avermitilis MA-4680 hypothetical protein NP_822419.1 1543003 R 227882 CDS NP_822420.1 29827786 1210159 complement(1543977..1544753) 1 NC_003155.4 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1544753 echA4 1210159 echA4 Streptomyces avermitilis MA-4680 enoyl-CoA hydratase NP_822420.1 1543977 R 227882 CDS NP_822421.1 29827787 1210160 1544829..1546583 1 NC_003155.4 activates fatty acids by binding to coenzyme A; in Mycobacterium may be involved in virulence; acyl-CoA synthetase 1546583 fadD4 1210160 fadD4 Streptomyces avermitilis MA-4680 acyl-CoA synthetase NP_822421.1 1544829 D 227882 CDS NP_822422.1 29827788 1210161 1546700..1547473 1 NC_003155.4 cyclic nucleotide phosphodiesterase 1547473 cpdA 1210161 cpdA Streptomyces avermitilis MA-4680 cyclic nucleotide phosphodiesterase NP_822422.1 1546700 D 227882 CDS NP_822423.1 29827789 1212857 complement(1547571..1548623) 1 NC_003155.4 PF01590: GAF domain; hypothetical protein 1548623 1212857 SAV_1248 Streptomyces avermitilis MA-4680 hypothetical protein NP_822423.1 1547571 R 227882 CDS NP_822424.1 29827790 1212858 1549424..1551430 1 NC_003155.4 nrps8 gene cluster; modular polyketide synthase 1551430 1212858 SAV_1249 Streptomyces avermitilis MA-4680 modular polyketide synthase NP_822424.1 1549424 D 227882 CDS NP_822425.1 29827791 1212859 1551427..1552974 1 NC_003155.4 nrps8 gene cluster; non-ribosomal peptide synthetase 1552974 nrps8 1212859 nrps8 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_822425.1 1551427 D 227882 CDS NP_822426.1 29827792 1212860 1553040..1554224 1 NC_003155.4 nrps8 gene cluster; hydroxylase 1554224 1212860 SAV_1251 Streptomyces avermitilis MA-4680 hydroxylase NP_822426.1 1553040 D 227882 CDS NP_822427.1 29827793 1210162 1554555..1557221 1 NC_003155.4 multi-component regulatory system-1; sensor-like histidine kinase 1557221 cvnA1 1210162 cvnA1 Streptomyces avermitilis MA-4680 sensor-like histidine kinase NP_822427.1 1554555 D 227882 CDS NP_822428.1 29827794 1210163 1557218..1557667 1 NC_003155.4 multi-component regulatory system-1, PF03259: Roadblock/LC7 domain; hypothetical protein 1557667 cvnB1 1210163 cvnB1 Streptomyces avermitilis MA-4680 hypothetical protein NP_822428.1 1557218 D 227882 CDS NP_822429.1 29827795 1210164 1557660..1558034 1 NC_003155.4 multi-component regulatory system-1, PF05331: Protein of unknown function (DUF742); hypothetical protein 1558034 cvnC1 1210164 cvnC1 Streptomyces avermitilis MA-4680 hypothetical protein NP_822429.1 1557660 D 227882 CDS NP_822430.1 29827796 1210165 1558015..1558614 1 NC_003155.4 multi-component regulatory system-1; ATP/GTP-binding protein 1558614 cvnD1 1210165 cvnD1 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_822430.1 1558015 D 227882 CDS NP_822431.1 29827797 1212861 complement(1558633..1559469) 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 1559469 1212861 SAV_1256 Streptomyces avermitilis MA-4680 hydrolase NP_822431.1 1558633 R 227882 CDS NP_822432.1 29827798 1210166 1559656..1560951 1 NC_003155.4 phenylacetate:CoA ligase 1560951 paaK 1210166 paaK Streptomyces avermitilis MA-4680 phenylacetate:CoA ligase NP_822432.1 1559656 D 227882 CDS NP_822433.1 29827799 1210167 complement(1561000..1562499) 1 NC_003155.4 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 1562499 fadD5 1210167 fadD5 Streptomyces avermitilis MA-4680 acyl-CoA synthetase NP_822433.1 1561000 R 227882 CDS NP_822434.1 29827800 1210168 complement(1562796..1564346) 1 NC_003155.4 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 1564346 fadD6 1210168 fadD6 Streptomyces avermitilis MA-4680 long-chain-fatty-acid--CoA ligase NP_822434.1 1562796 R 227882 CDS NP_822435.1 29827801 1212862 complement(1564343..1565452) 1 NC_003155.4 PF03060: 2-nitropropane dioxygenase; dioxygenase 1565452 1212862 SAV_1260 Streptomyces avermitilis MA-4680 dioxygenase NP_822435.1 1564343 R 227882 CDS NP_822436.1 29827802 1210169 1565622..1567469 1 NC_003155.4 PF00144: Beta-lactamase; beta-lactamase 1567469 blaA1 1210169 blaA1 Streptomyces avermitilis MA-4680 beta-lactamase NP_822436.1 1565622 D 227882 CDS NP_822437.1 29827803 1212863 1567506..1568018 1 NC_003155.4 hypothetical protein 1568018 1212863 SAV_1262 Streptomyces avermitilis MA-4680 hypothetical protein NP_822437.1 1567506 D 227882 CDS NP_822438.1 29827804 1212864 complement(1568444..1569079) 1 NC_003155.4 TetR family transcriptional regulator 1569079 1212864 SAV_1263 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_822438.1 1568444 R 227882 CDS NP_822439.1 29827805 1212865 complement(1569085..1570686) 1 NC_003155.4 PF01593: Flavin containing amine oxidoreductase; oxidoreductase 1570686 1212865 SAV_1264 Streptomyces avermitilis MA-4680 oxidoreductase NP_822439.1 1569085 R 227882 CDS NP_822440.1 29827806 1210170 complement(1570968..1573232) 1 NC_003155.4 serine/threonine protein kinase 1573232 pkn4 1210170 pkn4 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_822440.1 1570968 R 227882 CDS NP_822441.1 29827807 1212866 complement(1573293..1574150) 1 NC_003155.4 hypothetical protein 1574150 1212866 SAV_1266 Streptomyces avermitilis MA-4680 hypothetical protein NP_822441.1 1573293 R 227882 CDS NP_822442.1 29827808 1210171 complement(1574160..1575338) 1 NC_003155.4 PF02770: Acyl-CoA dehydrogenase, middle domain; acyl-CoA dehydrogenase 1575338 fadE14 1210171 fadE14 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_822442.1 1574160 R 227882 CDS NP_822443.1 29827809 1212867 complement(1575577..1576035) 1 NC_003155.4 PF03860: Domain of Unknown Function (DUF326); hypothetical protein 1576035 1212867 SAV_1268 Streptomyces avermitilis MA-4680 hypothetical protein NP_822443.1 1575577 R 227882 CDS NP_822444.1 29827810 1212868 complement(1576268..1576669) 1 NC_003155.4 hypothetical protein 1576669 1212868 SAV_1269 Streptomyces avermitilis MA-4680 hypothetical protein NP_822444.1 1576268 R 227882 CDS NP_822445.1 29827811 1212869 1576753..1577319 1 NC_003155.4 PadR-like family transcriptional regulator 1577319 1212869 SAV_1270 Streptomyces avermitilis MA-4680 PadR-like family transcriptional regulator NP_822445.1 1576753 D 227882 CDS NP_822446.1 29827812 1212870 complement(1577424..1578050) 1 NC_003155.4 DNA-binding protein 1578050 1212870 SAV_1271 Streptomyces avermitilis MA-4680 DNA-binding protein NP_822446.1 1577424 R 227882 CDS NP_822447.1 29827813 1212871 complement(1578130..1579200) 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 1579200 1212871 SAV_1272 Streptomyces avermitilis MA-4680 dehydrogenase NP_822447.1 1578130 R 227882 CDS NP_822448.1 29827814 1212872 complement(1579336..1581717) 1 NC_003155.4 PF03894: D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; putative phosphoketolase 1581717 1212872 SAV_1273 Streptomyces avermitilis MA-4680 putative phosphoketolase NP_822448.1 1579336 R 227882 CDS NP_822449.1 29827815 1212873 1581753..1582556 1 NC_003155.4 regulatory protein 1582556 1212873 SAV_1274 Streptomyces avermitilis MA-4680 regulatory protein NP_822449.1 1581753 D 227882 CDS NP_822450.1 29827816 1212874 complement(1582571..1583443) 1 NC_003155.4 stress-inducible protein 1583443 1212874 SAV_1275 Streptomyces avermitilis MA-4680 stress-inducible protein NP_822450.1 1582571 R 227882 CDS NP_822451.1 29827817 1212875 complement(1583527..1583880) 1 NC_003155.4 hypothetical protein 1583880 1212875 SAV_1276 Streptomyces avermitilis MA-4680 hypothetical protein NP_822451.1 1583527 R 227882 CDS NP_822452.1 29827818 1212876 complement(1583840..1586992) 1 NC_003155.4 PF05729: NACHT domain; hypothetical protein 1586992 1212876 SAV_1277 Streptomyces avermitilis MA-4680 hypothetical protein NP_822452.1 1583840 R 227882 CDS NP_822453.1 29827819 1212877 1587146..1587679 1 NC_003155.4 PF00027: Cyclic nucleotide-binding domain; CRP-like regulatory protein 1587679 1212877 SAV_1278 Streptomyces avermitilis MA-4680 CRP-like regulatory protein NP_822453.1 1587146 D 227882 CDS NP_822454.1 29827820 1212878 1587800..1588627 1 NC_003155.4 PF04672: Protein of unknown function (DUF574); hypothetical protein 1588627 1212878 SAV_1279 Streptomyces avermitilis MA-4680 hypothetical protein NP_822454.1 1587800 D 227882 CDS NP_822455.1 29827821 1212879 complement(1588857..1589567) 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 1589567 1212879 SAV_1280 Streptomyces avermitilis MA-4680 dehydrogenase NP_822455.1 1588857 R 227882 CDS NP_822456.1 29827822 1212880 complement(1589771..1590874) 1 NC_003155.4 two-component system sensor kinase 1590874 1212880 SAV_1281 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_822456.1 1589771 R 227882 CDS NP_822457.1 29827823 1212881 complement(1590871..1591551) 1 NC_003155.4 two-component system response regulator 1591551 1212881 SAV_1282 Streptomyces avermitilis MA-4680 two-component system response regulator NP_822457.1 1590871 R 227882 CDS NP_822458.1 29827824 1212882 1591712..1592941 1 NC_003155.4 PF04235: Protein of unknown function (DUF418); hypothetical protein 1592941 1212882 SAV_1283 Streptomyces avermitilis MA-4680 hypothetical protein NP_822458.1 1591712 D 227882 CDS NP_822459.1 29827825 1212883 1593064..1593717 1 NC_003155.4 PF00300: Phosphoglycerate mutase family; hypothetical protein 1593717 1212883 SAV_1284 Streptomyces avermitilis MA-4680 hypothetical protein NP_822459.1 1593064 D 227882 CDS NP_822460.1 29827826 1210172 1594134..1595126 1 NC_003155.4 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK 1595126 dak1 1210172 dak1 Streptomyces avermitilis MA-4680 dihydroxyacetone kinase subunit DhaK NP_822460.1 1594134 D 227882 CDS NP_822461.1 29827827 1210173 1595172..1595771 1 NC_003155.4 PF02734: Dak2 domain; dihydroxyacetone kinase subunit 2 1595771 dak2 1210173 dak2 Streptomyces avermitilis MA-4680 dihydroxyacetone kinase subunit 2 NP_822461.1 1595172 D 227882 CDS NP_822462.1 29827828 1212884 1595764..1596180 1 NC_003155.4 PF03610: PTS system fructose IIA component; dihydroxyacetone kinase phosphotransfer protein 1596180 1212884 SAV_1287 Streptomyces avermitilis MA-4680 dihydroxyacetone kinase phosphotransfer protein NP_822462.1 1595764 D 227882 CDS NP_822463.1 29827829 1212885 complement(1596355..1597128) 1 NC_003155.4 PF07335: Fungal chitosanase; protein 1597128 1212885 SAV_1288 Streptomyces avermitilis MA-4680 protein NP_822463.1 1596355 R 227882 CDS NP_822464.1 29827830 1212886 1597420..1598451 1 NC_003155.4 PF00041: Fibronectin type III domain; sugar hydrolase 1598451 1212886 SAV_1289 Streptomyces avermitilis MA-4680 sugar hydrolase NP_822464.1 1597420 D 227882 CDS NP_822465.1 29827831 1212887 1598664..1599200 1 NC_003155.4 hypothetical protein 1599200 1212887 SAV_1290 Streptomyces avermitilis MA-4680 hypothetical protein NP_822465.1 1598664 D 227882 CDS NP_822466.1 29827832 1212888 complement(1599274..1599819) 1 NC_003155.4 PadR-like family transcriptional regulator 1599819 1212888 SAV_1291 Streptomyces avermitilis MA-4680 PadR-like family transcriptional regulator NP_822466.1 1599274 R 227882 CDS NP_822467.1 29827833 1210174 complement(1599862..1601877) 1 NC_003155.4 PF00724: NADH:flavin oxidoreductase / NADH oxidase family; 2,4-dienoyl-CoA reductase 1601877 fadH 1210174 fadH Streptomyces avermitilis MA-4680 2,4-dienoyl-CoA reductase NP_822467.1 1599862 R 227882 CDS NP_822468.1 29827834 1212889 complement(1602176..1602994) 1 NC_003155.4 methyltransferase 1602994 1212889 SAV_1293 Streptomyces avermitilis MA-4680 methyltransferase NP_822468.1 1602176 R 227882 CDS NP_822469.1 29827835 1212890 complement(1603173..1604291) 1 NC_003155.4 hypothetical protein 1604291 1212890 SAV_1294 Streptomyces avermitilis MA-4680 hypothetical protein NP_822469.1 1603173 R 227882 CDS NP_822470.1 29827836 1212891 1604339..1604869 1 NC_003155.4 MarR family transcriptional regulator 1604869 1212891 SAV_1295 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_822470.1 1604339 D 227882 CDS NP_822471.1 29827837 1212892 complement(1604909..1605814) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 1605814 1212892 SAV_1296 Streptomyces avermitilis MA-4680 acetyltransferase NP_822471.1 1604909 R 227882 CDS NP_822472.1 29827838 1212893 complement(1605811..1606731) 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 1606731 1212893 SAV_1297 Streptomyces avermitilis MA-4680 dehydrogenase NP_822472.1 1605811 R 227882 CDS NP_822473.1 29827839 1212894 1606980..1607585 1 NC_003155.4 PF00174: Oxidoreductase molybdopterin binding domain; hypothetical protein 1607585 1212894 SAV_1298 Streptomyces avermitilis MA-4680 hypothetical protein NP_822473.1 1606980 D 227882 CDS NP_822474.1 29827840 1212895 1607578..1608333 1 NC_003155.4 PF00970: Oxidoreductase FAD-binding domain; oxidoreductase 1608333 1212895 SAV_1299 Streptomyces avermitilis MA-4680 oxidoreductase NP_822474.1 1607578 D 227882 CDS NP_822475.1 29827841 1212896 complement(1608351..1609238) 1 NC_003155.4 stress-inducible protein 1609238 1212896 SAV_1300 Streptomyces avermitilis MA-4680 stress-inducible protein NP_822475.1 1608351 R 227882 CDS NP_822476.1 29827842 1212897 1609344..1610210 1 NC_003155.4 hypothetical protein 1610210 1212897 SAV_1301 Streptomyces avermitilis MA-4680 hypothetical protein NP_822476.1 1609344 D 227882 CDS NP_822477.1 29827843 1210175 1610532..1611500 1 NC_003155.4 PF05448: Acetyl xylan esterase (AXE1); acetyl xylan esterase 1611500 axe1 1210175 axe1 Streptomyces avermitilis MA-4680 acetyl xylan esterase NP_822477.1 1610532 D 227882 CDS NP_822478.1 29827844 1212898 1611497..1611916 1 NC_003155.4 hypothetical protein 1611916 1212898 SAV_1303 Streptomyces avermitilis MA-4680 hypothetical protein NP_822478.1 1611497 D 227882 CDS NP_822479.1 29827845 1212899 1612092..1613258 1 NC_003155.4 esterase 1613258 1212899 SAV_1304 Streptomyces avermitilis MA-4680 esterase NP_822479.1 1612092 D 227882 CDS NP_822480.1 29827846 1212900 1613379..1614131 1 NC_003155.4 GntR family transcriptional regulator 1614131 1212900 SAV_1305 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_822480.1 1613379 D 227882 CDS NP_822481.1 29827847 1212901 complement(1614307..1615050) 1 NC_003155.4 methyltransferase 1615050 1212901 SAV_1306 Streptomyces avermitilis MA-4680 methyltransferase NP_822481.1 1614307 R 227882 CDS NP_822482.1 29827848 1210176 1615206..1616795 1 NC_003155.4 oligo-1,6-glucosidase 1616795 dexA 1210176 dexA Streptomyces avermitilis MA-4680 oligo-1,6-glucosidase NP_822482.1 1615206 D 227882 CDS NP_822483.1 29827849 1210177 complement(1616797..1618128) 1 NC_003155.4 CYP154D1; cytochrome P450 hydroxylase 1618128 cyp6 1210177 cyp6 Streptomyces avermitilis MA-4680 cytochrome P450 hydroxylase NP_822483.1 1616797 R 227882 CDS NP_822484.1 29827850 1212902 complement(1618155..1619378) 1 NC_003155.4 PF02771: Acyl-CoA dehydrogenase, N-terminal domain; hypothetical protein 1619378 1212902 SAV_1309 Streptomyces avermitilis MA-4680 hypothetical protein NP_822484.1 1618155 R 227882 CDS NP_822485.1 29827851 1210178 1619721..1620860 1 NC_003155.4 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 1620860 rho 1210178 rho Streptomyces avermitilis MA-4680 transcription termination factor Rho NP_822485.1 1619721 D 227882 CDS NP_822486.1 29827852 1210179 1620939..1622105 1 NC_003155.4 PF00768: D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase 1622105 dacA 1210179 dacA Streptomyces avermitilis MA-4680 D-alanyl-D-alanine carboxypeptidase NP_822486.1 1620939 D 227882 CDS NP_822487.1 29827853 1212903 complement(1621832..1623214) 1 NC_003155.4 hypothetical protein 1623214 1212903 SAV_1312 Streptomyces avermitilis MA-4680 hypothetical protein NP_822487.1 1621832 R 227882 CDS NP_822488.1 29827854 1212904 complement(1623211..1624611) 1 NC_003155.4 hypothetical protein 1624611 1212904 SAV_1313 Streptomyces avermitilis MA-4680 hypothetical protein NP_822488.1 1623211 R 227882 CDS NP_822489.1 29827855 1210180 complement(1624746..1625687) 1 NC_003155.4 catalyzes the formation of glutamate from glutamine; glutaminase 1625687 glsA 1210180 glsA Streptomyces avermitilis MA-4680 glutaminase NP_822489.1 1624746 R 227882 CDS NP_822490.1 29827856 1210181 complement(1625891..1627303) 1 NC_003155.4 catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 1627303 aspA 1210181 aspA Streptomyces avermitilis MA-4680 aspartate ammonia-lyase NP_822490.1 1625891 R 227882 CDS NP_822491.1 29827857 1212905 complement(1627395..1628381) 1 NC_003155.4 L-asparaginase II 1628381 1212905 SAV_1316 Streptomyces avermitilis MA-4680 L-asparaginase II NP_822491.1 1627395 R 227882 CDS NP_822492.1 29827858 1212906 complement(1628423..1629883) 1 NC_003155.4 L-asparagine permease 1629883 ansP1 1212906 ansP1 Streptomyces avermitilis MA-4680 L-asparagine permease NP_822492.1 1628423 R 227882 CDS NP_822493.1 29827859 1212907 complement(1629880..1630647) 1 NC_003155.4 GntR-family transcriptional regulator; L-asparagine operon repressor 1630647 1212907 SAV_1318 Streptomyces avermitilis MA-4680 L-asparagine operon repressor NP_822493.1 1629880 R 227882 CDS NP_822494.1 29827860 1210182 complement(1630747..1631580) 1 NC_003155.4 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters UDP disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase 1631580 uppP 1210182 uppP Streptomyces avermitilis MA-4680 UDP pyrophosphate phosphatase NP_822494.1 1630747 R 227882 CDS NP_822495.1 29827861 1212908 complement(1631650..1632024) 1 NC_003155.4 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1632024 ccrB 1212908 ccrB Streptomyces avermitilis MA-4680 camphor resistance protein CrcB NP_822495.1 1631650 R 227882 CDS NP_822496.1 29827862 1212909 complement(1632021..1632263) 1 NC_003155.4 PF02641: Uncharacterized ACR, COG1993; hypothetical protein 1632263 1212909 SAV_1321 Streptomyces avermitilis MA-4680 hypothetical protein NP_822496.1 1632021 R 227882 CDS NP_822497.1 29827863 1212910 complement(1632260..1632736) 1 NC_003155.4 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1632736 ccrB 1212910 ccrB Streptomyces avermitilis MA-4680 camphor resistance protein CrcB NP_822497.1 1632260 R 227882 CDS NP_822498.1 29827864 1212911 complement(1633159..1633446) 1 NC_003155.4 hypothetical protein 1633446 1212911 SAV_1323 Streptomyces avermitilis MA-4680 hypothetical protein NP_822498.1 1633159 R 227882 CDS NP_822499.1 29827865 1212912 complement(1633617..1635185) 1 NC_003155.4 arabinogalactan endo-1,4-beta-galactosidase 1635185 1212912 SAV_1324 Streptomyces avermitilis MA-4680 arabinogalactan endo-1,4-beta-galactosidase NP_822499.1 1633617 R 227882 CDS NP_822500.1 29827866 1210183 complement(1635320..1637341) 1 NC_003155.4 beta-galactosidase 1637341 bga2 1210183 bga2 Streptomyces avermitilis MA-4680 beta-galactosidase NP_822500.1 1635320 R 227882 CDS NP_822501.1 29827867 1212913 1637527..1638846 1 NC_003155.4 PF00497: Bacterial extracellular solute-binding proteins, family 3; solute-binding lipoprotein 1638846 1212913 SAV_1326 Streptomyces avermitilis MA-4680 solute-binding lipoprotein NP_822501.1 1637527 D 227882 CDS NP_822502.1 29827868 1212914 1638843..1639766 1 NC_003155.4 ABC transporter permease 1639766 1212914 SAV_1327 Streptomyces avermitilis MA-4680 ABC transporter permease NP_822502.1 1638843 D 227882 CDS NP_822503.1 29827869 1212915 1639763..1640668 1 NC_003155.4 ABC transporter permease 1640668 1212915 SAV_1328 Streptomyces avermitilis MA-4680 ABC transporter permease NP_822503.1 1639763 D 227882 CDS NP_822504.1 29827870 1212916 1640665..1641696 1 NC_003155.4 LacI family transcriptional regulator 1641696 1212916 SAV_1329 Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_822504.1 1640665 D 227882 CDS NP_822505.1 29827871 1212917 1641935..1642291 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein 1642291 1212917 SAV_1330 Streptomyces avermitilis MA-4680 hypothetical protein NP_822505.1 1641935 D 227882 CDS NP_822506.1 29827872 1212918 1642375..1642764 1 NC_003155.4 MarR family transcriptional regulator 1642764 1212918 SAV_1331 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_822506.1 1642375 D 227882 CDS NP_822507.1 29827873 1212919 1642815..1643843 1 NC_003155.4 PF02913: FAD linked oxidases, C-terminal domain; oxidoreductase 1643843 1212919 SAV_1332 Streptomyces avermitilis MA-4680 oxidoreductase NP_822507.1 1642815 D 227882 CDS NP_822508.1 29827874 1212920 complement(1644029..1644448) 1 NC_003155.4 hypothetical protein 1644448 1212920 SAV_1333 Streptomyces avermitilis MA-4680 hypothetical protein NP_822508.1 1644029 R 227882 CDS NP_822509.1 29827875 1212921 1645153..1646346 1 NC_003155.4 membrane protein; magnesium or manganese-dependent protein phosphatase 1646346 prpB6 1212921 prpB6 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_822509.1 1645153 D 227882 CDS NP_822510.1 29827876 1212922 complement(1646423..1646920) 1 NC_003155.4 hypothetical protein 1646920 1212922 SAV_1335 Streptomyces avermitilis MA-4680 hypothetical protein NP_822510.1 1646423 R 227882 CDS NP_822511.1 29827877 1212923 complement(1647024..1648022) 1 NC_003155.4 rhodanese family protein 1648022 1212923 SAV_1336 Streptomyces avermitilis MA-4680 rhodanese family protein NP_822511.1 1647024 R 227882 CDS NP_822512.1 29827878 1212924 1648366..1649301 1 NC_003155.4 ABC transporter substrate-binding protein 1649301 1212924 SAV_1337 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_822512.1 1648366 D 227882 CDS NP_822513.1 29827879 1212925 1649428..1650465 1 NC_003155.4 ABC transporter substrate-binding protein 1650465 1212925 SAV_1338 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_822513.1 1649428 D 227882 CDS NP_822514.1 29827880 1212926 1650462..1651235 1 NC_003155.4 ABC transporter permease 1651235 1212926 SAV_1339 Streptomyces avermitilis MA-4680 ABC transporter permease NP_822514.1 1650462 D 227882 CDS NP_822515.1 29827881 1212927 1651199..1652026 1 NC_003155.4 ABC transporter ATP-binding protein 1652026 1212927 SAV_1340 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_822515.1 1651199 D 227882 CDS NP_822516.1 29827882 1212928 1652023..1653147 1 NC_003155.4 PF01636: Phosphotransferase enzyme family; hypothetical protein 1653147 1212928 SAV_1341 Streptomyces avermitilis MA-4680 hypothetical protein NP_822516.1 1652023 D 227882 CDS NP_822517.1 29827883 1212929 1653663..1655132 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 1655132 1212929 SAV_1342 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_822517.1 1653663 D 227882 CDS NP_822518.1 29827884 1212930 complement(1655307..1656512) 1 NC_003155.4 PF00923: Transaldolase; hypothetical protein 1656512 1212930 SAV_1343 Streptomyces avermitilis MA-4680 hypothetical protein NP_822518.1 1655307 R 227882 CDS NP_822519.1 29827885 1212931 complement(1656575..1657990) 1 NC_003155.4 PF01593: Flavin containing amine oxidoreductase; dehydrogenase 1657990 1212931 SAV_1344 Streptomyces avermitilis MA-4680 dehydrogenase NP_822519.1 1656575 R 227882 CDS NP_822520.1 29827886 1212932 complement(1657983..1659725) 1 NC_003155.4 hypothetical protein 1659725 1212932 SAV_1345 Streptomyces avermitilis MA-4680 hypothetical protein NP_822520.1 1657983 R 227882 CDS NP_822521.1 29827887 1212933 complement(1659744..1661201) 1 NC_003155.4 acid:CoA ligase 1661201 1212933 SAV_1346 Streptomyces avermitilis MA-4680 acid:CoA ligase NP_822521.1 1659744 R 227882 CDS NP_822522.1 29827888 1210184 complement(1661612..1662823) 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; glutaryl-CoA dehydrogenase 1662823 gcdH2 1210184 gcdH2 Streptomyces avermitilis MA-4680 glutaryl-CoA dehydrogenase NP_822522.1 1661612 R 227882 CDS NP_822523.1 29827889 1210185 complement(1662820..1663776) 1 NC_003155.4 PF02737: 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; 3-hydroxyacyl-CoA dehydrogenase 1663776 fadC7 1210185 fadC7 Streptomyces avermitilis MA-4680 3-hydroxyacyl-CoA dehydrogenase NP_822523.1 1662820 R 227882 CDS NP_822524.1 29827890 1210186 complement(1663815..1664570) 1 NC_003155.4 converts acetoacetate to acetone and carbon dioxide; acetoacetate decarboxylase 1664570 adc 1210186 adc Streptomyces avermitilis MA-4680 acetoacetate decarboxylase NP_822524.1 1663815 R 227882 CDS NP_822525.1 29827891 1210187 complement(1664591..1665361) 1 NC_003155.4 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1665361 echA5 1210187 echA5 Streptomyces avermitilis MA-4680 enoyl-CoA hydratase NP_822525.1 1664591 R 227882 CDS NP_822526.1 29827892 1212934 complement(1665388..1666557) 1 NC_003155.4 fatty acid-CoA racemase 1666557 1212934 SAV_1351 Streptomyces avermitilis MA-4680 fatty acid-CoA racemase NP_822526.1 1665388 R 227882 CDS NP_822527.1 29827893 1212935 complement(1666726..1667637) 1 NC_003155.4 LysR family transcriptional regulator 1667637 1212935 SAV_1352 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_822527.1 1666726 R 227882 CDS NP_822528.1 29827894 1212936 complement(1667828..1669231) 1 NC_003155.4 PF00754: F5/8 type C domain; protein 1669231 1212936 SAV_1353 Streptomyces avermitilis MA-4680 protein NP_822528.1 1667828 R 227882 CDS NP_822529.1 29827895 1212937 complement(1669689..1671080) 1 NC_003155.4 amino acid permease 1671080 1212937 SAV_1354 Streptomyces avermitilis MA-4680 amino acid permease NP_822529.1 1669689 R 227882 CDS NP_822530.1 29827896 1212938 complement(1671135..1672004) 1 NC_003155.4 PF00795: Carbon-nitrogen hydrolase; hydrolase 1672004 1212938 SAV_1355 Streptomyces avermitilis MA-4680 hydrolase NP_822530.1 1671135 R 227882 CDS NP_822531.1 29827897 1212939 1672099..1672869 1 NC_003155.4 GntR family transcriptional regulator 1672869 1212939 SAV_1356 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_822531.1 1672099 D 227882 CDS NP_822532.1 29827898 1212940 1673000..1674022 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; alcohol dehydrogenase 1674022 adhA2 1212940 adhA2 Streptomyces avermitilis MA-4680 alcohol dehydrogenase NP_822532.1 1673000 D 227882 CDS NP_822533.1 29827899 1212941 complement(1674152..1674853) 1 NC_003155.4 hypothetical protein 1674853 1212941 SAV_1358 Streptomyces avermitilis MA-4680 hypothetical protein NP_822533.1 1674152 R 227882 CDS NP_822534.1 29827900 1212942 1674937..1675689 1 NC_003155.4 TetR family transcriptional regulator 1675689 1212942 SAV_1359 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_822534.1 1674937 D 227882 CDS NP_822535.1 29827901 1212943 1675968..1676225 1 NC_003155.4 hypothetical protein 1676225 1212943 SAV_1360 Streptomyces avermitilis MA-4680 hypothetical protein NP_822535.1 1675968 D 227882 CDS NP_822536.1 29827902 1212944 1676443..1677468 1 NC_003155.4 hypothetical protein 1677468 1212944 SAV_1361 Streptomyces avermitilis MA-4680 hypothetical protein NP_822536.1 1676443 D 227882 CDS NP_822537.1 29827903 1212945 complement(1677776..1678258) 1 NC_003155.4 transcriptional regulator 1678258 1212945 SAV_1362 Streptomyces avermitilis MA-4680 transcriptional regulator NP_822537.1 1677776 R 227882 CDS NP_822538.1 29827904 1212946 1678404..1679132 1 NC_003155.4 PF01113: Dihydrodipicolinate reductase, N-terminus; protein 1679132 1212946 SAV_1363 Streptomyces avermitilis MA-4680 protein NP_822538.1 1678404 D 227882 CDS NP_822539.1 29827905 1212947 1679068..1680150 1 NC_003155.4 hypothetical protein 1680150 1212947 SAV_1364 Streptomyces avermitilis MA-4680 hypothetical protein NP_822539.1 1679068 D 227882 CDS NP_822540.1 29827906 1212948 complement(1680147..1680689) 1 NC_003155.4 hypothetical protein 1680689 1212948 SAV_1365 Streptomyces avermitilis MA-4680 hypothetical protein NP_822540.1 1680147 R 227882 CDS NP_822541.1 29827907 1212949 1680974..1683826 1 NC_003155.4 PF01447: Thermolysin metallopeptidase, catalytic domain; metalloprotease 1683826 1212949 SAV_1366 Streptomyces avermitilis MA-4680 metalloprotease NP_822541.1 1680974 D 227882 CDS NP_822542.1 29827908 1212950 complement(1684007..1684810) 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 1684810 1212950 SAV_1367 Streptomyces avermitilis MA-4680 dehydrogenase NP_822542.1 1684007 R 227882 CDS NP_822543.1 29827909 1212951 complement(1684807..1685763) 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 1685763 1212951 SAV_1368 Streptomyces avermitilis MA-4680 dehydrogenase NP_822543.1 1684807 R 227882 CDS NP_822544.1 29827910 1212952 1686236..1686775 1 NC_003155.4 PF04341: Protein of unknown function, DUF485; hypothetical protein 1686775 1212952 SAV_1369 Streptomyces avermitilis MA-4680 hypothetical protein NP_822544.1 1686236 D 227882 CDS NP_822545.1 29827911 1212953 1686772..1688388 1 NC_003155.4 PF00474: Sodium:solute symporter family; transmembrane transport protein 1688388 1212953 SAV_1370 Streptomyces avermitilis MA-4680 transmembrane transport protein NP_822545.1 1686772 D 227882 CDS NP_822546.1 29827912 1212954 1688543..1689622 1 NC_003155.4 AraC family transcription regulator 1689622 1212954 SAV_1371 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_822546.1 1688543 D 227882 CDS NP_822547.1 29827913 1210189 1689619..1691415 1 NC_003155.4 acetolactate synthase 1691415 ilvB2 1210189 ilvB2 Streptomyces avermitilis MA-4680 acetolactate synthase NP_822547.1 1689619 D 227882 CDS NP_822548.1 29827914 1212955 1691387..1692040 1 NC_003155.4 hypothetical protein 1692040 1212955 SAV_1373 Streptomyces avermitilis MA-4680 hypothetical protein NP_822548.1 1691387 D 227882 CDS NP_822549.1 29827915 1210190 1692037..1693056 1 NC_003155.4 3-oxoacyl-ACP synthase III 1693056 fabH5 1210190 fabH5 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP synthase III NP_822549.1 1692037 D 227882 CDS NP_822550.1 29827916 1210191 1693060..1694154 1 NC_003155.4 EC:2.6.1.9; histidinol-phosphate aminotransferase 1694154 hisC3 1210191 hisC3 Streptomyces avermitilis MA-4680 histidinol-phosphate aminotransferase NP_822550.1 1693060 D 227882 CDS NP_822551.1 29827917 1212956 complement(1694414..1695211) 1 NC_003155.4 PF07398: Protein of unknown function (DUF1503); hypothetical protein 1695211 1212956 SAV_1376 Streptomyces avermitilis MA-4680 hypothetical protein NP_822551.1 1694414 R 227882 CDS NP_822552.1 29827918 1212957 complement(1695242..1695415) 1 NC_003155.4 hypothetical protein 1695415 1212957 SAV_1377 Streptomyces avermitilis MA-4680 hypothetical protein NP_822552.1 1695242 R 227882 CDS NP_822553.1 29827919 1212958 complement(1695483..1696991) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; membrane transport protein 1696991 1212958 SAV_1378 Streptomyces avermitilis MA-4680 membrane transport protein NP_822553.1 1695483 R 227882 CDS NP_822554.1 29827920 1212959 1697123..1697560 1 NC_003155.4 MarR family transcriptional regulator 1697560 1212959 SAV_1379 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_822554.1 1697123 D 227882 CDS NP_822555.1 29827921 1212960 complement(1697945..1698727) 1 NC_003155.4 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1698727 fabG 1212960 fabG Streptomyces avermitilis MA-4680 3-ketoacyl-ACP reductase NP_822555.1 1697945 R 227882 CDS NP_822556.1 29827922 1210192 complement(1698729..1699994) 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 1699994 fadE15 1210192 fadE15 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_822556.1 1698729 R 227882 CDS NP_822557.1 29827923 1212961 complement(1700439..1701167) 1 NC_003155.4 TetR family transcriptional regulator 1701167 1212961 SAV_1382 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_822557.1 1700439 R 227882 CDS NP_822558.1 29827924 1212962 complement(1701234..1701881) 1 NC_003155.4 PF00702: haloacid dehalogenase-like hydrolase; hydrolase 1701881 1212962 SAV_1383 Streptomyces avermitilis MA-4680 hydrolase NP_822558.1 1701234 R 227882 CDS NP_822559.1 29827925 1210193 complement(1702011..1703210) 1 NC_003155.4 atoB: acetyl-CoA C-acetyltransferase, PF00108: Thiolase, N-terminal domain; 3-ketoacyl-CoA thiolase 1703210 fadA5 1210193 fadA5 Streptomyces avermitilis MA-4680 3-ketoacyl-CoA thiolase NP_822559.1 1702011 R 227882 CDS NP_822560.1 29827926 1212963 complement(1703980..1705092) 1 NC_003155.4 hypothetical protein 1705092 1212963 SAV_1385 Streptomyces avermitilis MA-4680 hypothetical protein NP_822560.1 1703980 R 227882 CDS NP_822561.1 29827927 1212964 complement(1706772..1708142) 1 NC_003155.4 similar to glycolate oxidase: PF01565: FAD binding domain; (S)-2-hydroxy-acid oxidase 1708142 glcD1 1212964 glcD1 Streptomyces avermitilis MA-4680 (S)-2-hydroxy-acid oxidase NP_822561.1 1706772 R 227882 CDS NP_822562.1 29827928 1212965 complement(1708139..1708849) 1 NC_003155.4 GntR family transcriptional regulator 1708849 1212965 SAV_1387 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_822562.1 1708139 R 227882 CDS NP_822563.1 29827929 1212966 1708859..1709566 1 NC_003155.4 PF00857: Isochorismatase family; isochorismatase 1709566 1212966 SAV_1388 Streptomyces avermitilis MA-4680 isochorismatase NP_822563.1 1708859 D 227882 CDS NP_822564.1 29827930 1212967 1709632..1710909 1 NC_003155.4 hypothetical protein 1710909 1212967 SAV_1389 Streptomyces avermitilis MA-4680 hypothetical protein NP_822564.1 1709632 D 227882 CDS NP_822565.1 29827931 1212968 1711093..1712622 1 NC_003155.4 PF00743: Flavin-binding monooxygenase-like; aromatic-ring hydroxylase 1712622 1212968 SAV_1390 Streptomyces avermitilis MA-4680 aromatic-ring hydroxylase NP_822565.1 1711093 D 227882 CDS NP_822566.1 29827932 1212969 complement(1714511..1717072) 1 NC_003155.4 PF00989: PAS domain, PF01590: GAF domain; magnesium or manganese-dependent protein phosphatase 1717072 prpJ5 1212969 prpJ5 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_822566.1 1714511 R 227882 CDS NP_822567.1 29827933 1212970 complement(1717280..1719070) 1 NC_003155.4 PF01590: GAF domain; transcriptional regulator 1719070 1212970 SAV_1392 Streptomyces avermitilis MA-4680 transcriptional regulator NP_822567.1 1717280 R 227882 CDS NP_822568.1 29827934 1212971 1719247..1720272 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; alcohol dehydrogenase 1720272 adhA3 1212971 adhA3 Streptomyces avermitilis MA-4680 alcohol dehydrogenase NP_822568.1 1719247 D 227882 CDS NP_822569.1 29827935 1212972 1720293..1721894 1 NC_003155.4 ABC transporter substrate-binding protein 1721894 1212972 SAV_1394 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_822569.1 1720293 D 227882 CDS NP_822570.1 29827936 1212973 1721916..1722854 1 NC_003155.4 ABC transporter permease 1722854 1212973 SAV_1395 Streptomyces avermitilis MA-4680 ABC transporter permease NP_822570.1 1721916 D 227882 CDS NP_822571.1 29827937 1212974 1722851..1723696 1 NC_003155.4 ABC transporter permease 1723696 1212974 SAV_1396 Streptomyces avermitilis MA-4680 ABC transporter permease NP_822571.1 1722851 D 227882 CDS NP_822572.1 29827938 1212975 1723693..1724781 1 NC_003155.4 sugar ABC transporter ATP-binding protein 1724781 1212975 SAV_1397 Streptomyces avermitilis MA-4680 sugar ABC transporter ATP-binding protein NP_822572.1 1723693 D 227882 CDS NP_822573.1 29827939 1212976 1724783..1725862 1 NC_003155.4 sugar ABC transporter ATP-binding protein 1725862 1212976 SAV_1398 Streptomyces avermitilis MA-4680 sugar ABC transporter ATP-binding protein NP_822573.1 1724783 D 227882 CDS NP_822574.1 29827940 1212977 1726146..1728530 1 NC_003155.4 hypothetical protein 1728530 1212977 SAV_1399 Streptomyces avermitilis MA-4680 hypothetical protein NP_822574.1 1726146 D 227882 CDS NP_822575.1 29827941 1212978 1728527..1729672 1 NC_003155.4 hypothetical protein 1729672 1212978 SAV_1400 Streptomyces avermitilis MA-4680 hypothetical protein NP_822575.1 1728527 D 227882 CDS NP_822576.1 29827942 1212979 1729690..1730592 1 NC_003155.4 hypothetical protein 1730592 1212979 SAV_1401 Streptomyces avermitilis MA-4680 hypothetical protein NP_822576.1 1729690 D 227882 CDS NP_822577.1 29827943 1212980 1730649..1731056 1 NC_003155.4 hypothetical protein 1731056 1212980 SAV_1402 Streptomyces avermitilis MA-4680 hypothetical protein NP_822577.1 1730649 D 227882 CDS NP_822578.1 29827944 1212981 1731053..1731502 1 NC_003155.4 hypothetical protein 1731502 1212981 SAV_1403 Streptomyces avermitilis MA-4680 hypothetical protein NP_822578.1 1731053 D 227882 CDS NP_822579.1 29827945 1212982 complement(1731705..1732691) 1 NC_003155.4 PF00248: Aldo/keto reductase family; oxidoreductase 1732691 1212982 SAV_1404 Streptomyces avermitilis MA-4680 oxidoreductase NP_822579.1 1731705 R 227882 CDS NP_822580.1 29827946 1212983 complement(1732688..1733521) 1 NC_003155.4 PF04909: Amidohydrolase; amidohydrolase 1733521 1212983 SAV_1405 Streptomyces avermitilis MA-4680 amidohydrolase NP_822580.1 1732688 R 227882 CDS NP_822581.1 29827947 1212984 1734129..1734905 1 NC_003155.4 GntR family transcriptional regulator 1734905 1212984 SAV_1406 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_822581.1 1734129 D 227882 CDS NP_822582.1 29827948 1212985 1734993..1738382 1 NC_003155.4 PF00041: Fibronectin type III domain; hypothetical protein 1738382 1212985 SAV_1407 Streptomyces avermitilis MA-4680 hypothetical protein NP_822582.1 1734993 D 227882 CDS NP_822583.1 29827949 1212986 1738439..1739536 1 NC_003155.4 racemase 1739536 1212986 SAV_1408 Streptomyces avermitilis MA-4680 racemase NP_822583.1 1738439 D 227882 CDS NP_822584.1 29827950 1212987 1739569..1740954 1 NC_003155.4 solute-binding protein 1740954 1212987 SAV_1409 Streptomyces avermitilis MA-4680 solute-binding protein NP_822584.1 1739569 D 227882 CDS NP_822585.1 29827951 1212988 1740951..1741883 1 NC_003155.4 ABC transporter permease 1741883 1212988 SAV_1410 Streptomyces avermitilis MA-4680 ABC transporter permease NP_822585.1 1740951 D 227882 CDS NP_822586.1 29827952 1212989 1741880..1742794 1 NC_003155.4 ABC transporter permease 1742794 1212989 SAV_1411 Streptomyces avermitilis MA-4680 ABC transporter permease NP_822586.1 1741880 D 227882 CDS NP_822587.1 29827953 1212990 1742840..1744534 1 NC_003155.4 hypothetical protein 1744534 1212990 SAV_1412 Streptomyces avermitilis MA-4680 hypothetical protein NP_822587.1 1742840 D 227882 CDS NP_822588.1 29827954 1210194 1744531..1745499 1 NC_003155.4 glucokinase 1745499 glkA2 1210194 glkA2 Streptomyces avermitilis MA-4680 glucokinase NP_822588.1 1744531 D 227882 CDS NP_822589.1 29827955 1212991 complement(1746233..1747186) 1 NC_003155.4 hypothetical protein 1747186 1212991 SAV_1414 Streptomyces avermitilis MA-4680 hypothetical protein NP_822589.1 1746233 R 227882 CDS NP_822590.1 29827956 1212992 complement(1747548..1747778) 1 NC_003155.4 protease 1747778 1212992 SAV_1415 Streptomyces avermitilis MA-4680 protease NP_822590.1 1747548 R 227882 CDS NP_822591.1 29827957 1212993 1748025..1748549 1 NC_003155.4 hypothetical protein 1748549 1212993 SAV_1416 Streptomyces avermitilis MA-4680 hypothetical protein NP_822591.1 1748025 D 227882 CDS NP_822592.1 29827958 1212994 1748916..1749656 1 NC_003155.4 hypothetical protein 1749656 1212994 SAV_1417 Streptomyces avermitilis MA-4680 hypothetical protein NP_822592.1 1748916 D 227882 CDS NP_822593.1 29827959 1212995 1750041..1751474 1 NC_003155.4 PF00083: Sugar (and other) transporter; transporter 1751474 1212995 SAV_1418 Streptomyces avermitilis MA-4680 transporter NP_822593.1 1750041 D 227882 CDS NP_822594.1 29827960 1212996 complement(1751539..1753476) 1 NC_003155.4 PF01590: GAF domain; hypothetical protein 1753476 1212996 SAV_1419 Streptomyces avermitilis MA-4680 hypothetical protein NP_822594.1 1751539 R 227882 CDS NP_822595.1 29827961 1212997 complement(1753546..1754346) 1 NC_003155.4 PF00106: short chain dehydrogenase; 3-hydroxybutyrate dehydrogenase 1754346 bdhA 1212997 bdhA Streptomyces avermitilis MA-4680 3-hydroxybutyrate dehydrogenase NP_822595.1 1753546 R 227882 CDS NP_822596.1 29827962 1212998 complement(1754407..1754880) 1 NC_003155.4 MutT/NUDIX-family protein 1754880 1212998 SAV_1421 Streptomyces avermitilis MA-4680 MutT/NUDIX-family protein NP_822596.1 1754407 R 227882 CDS NP_822597.1 29827963 1212999 complement(1754929..1756548) 1 NC_003155.4 polyprenol-phosphate-mannosyl transferase 1756548 1212999 SAV_1422 Streptomyces avermitilis MA-4680 polyprenol-phosphate-mannosyl transferase NP_822597.1 1754929 R 227882 CDS NP_822598.1 29827964 1213000 1756680..1757813 1 NC_003155.4 PF04932: O-Antigen Polymerase; hypothetical protein 1757813 1213000 SAV_1423 Streptomyces avermitilis MA-4680 hypothetical protein NP_822598.1 1756680 D 227882 CDS NP_822599.1 29827965 1213001 complement(1757862..1758407) 1 NC_003155.4 hypothetical protein 1758407 1213001 SAV_1424 Streptomyces avermitilis MA-4680 hypothetical protein NP_822599.1 1757862 R 227882 CDS NP_822600.1 29827966 1210195 complement(1758546..1759331) 1 NC_003155.4 glutamate racemase 1759331 murI 1210195 murI Streptomyces avermitilis MA-4680 glutamate racemase NP_822600.1 1758546 R 227882 CDS NP_822601.1 29827967 1213002 1759390..1760565 1 NC_003155.4 PF00535: Glycosyl transferase; glycosyl transferase 1760565 1213002 SAV_1426 Streptomyces avermitilis MA-4680 glycosyl transferase NP_822601.1 1759390 D 227882 CDS NP_822602.1 29827968 1213003 complement(1760590..1761915) 1 NC_003155.4 PF02342: Bacterial stress protein; tellurium resistance protein 1761915 terA 1213003 terA Streptomyces avermitilis MA-4680 tellurium resistance protein NP_822602.1 1760590 R 227882 CDS NP_822603.1 29827969 1213004 1762252..1762692 1 NC_003155.4 hypothetical protein 1762692 1213004 SAV_1428 Streptomyces avermitilis MA-4680 hypothetical protein NP_822603.1 1762252 D 227882 CDS NP_822604.1 29827970 1213005 1762737..1763561 1 NC_003155.4 PF03473: MOSC domain, PF03476: MOSC N-terminal beta barrel domain; hypothetical protein 1763561 1213005 SAV_1429 Streptomyces avermitilis MA-4680 hypothetical protein NP_822604.1 1762737 D 227882 CDS NP_822605.1 29827971 1213006 1763811..1764416 1 NC_003155.4 hypothetical protein 1764416 1213006 SAV_1430 Streptomyces avermitilis MA-4680 hypothetical protein NP_822605.1 1763811 D 227882 CDS NP_822606.1 29827972 1210196 1764524..1766962 1 NC_003155.4 ATPases of the AAA+ class, PF00004: ATPase family associated with various cellular activities (AAA); sporulation protein K-like protein 1766962 spoVK 1210196 spoVK Streptomyces avermitilis MA-4680 sporulation protein K-like protein NP_822606.1 1764524 D 227882 CDS NP_822607.1 29827973 1213007 complement(1766932..1769265) 1 NC_003155.4 hypothetical protein 1769265 1213007 SAV_1432 Streptomyces avermitilis MA-4680 hypothetical protein NP_822607.1 1766932 R 227882 CDS NP_822608.1 29827974 1213008 1769668..1770498 1 NC_003155.4 DeoR family transcriptional regulator 1770498 1213008 SAV_1433 Streptomyces avermitilis MA-4680 DeoR family transcriptional regulator NP_822608.1 1769668 D 227882 CDS NP_822609.1 29827975 1213009 1770611..1771090 1 NC_003155.4 PF03364: Streptomyces cyclase/dehydrase; hypothetical protein 1771090 1213009 SAV_1434 Streptomyces avermitilis MA-4680 hypothetical protein NP_822609.1 1770611 D 227882 CDS NP_822610.1 29827976 1213010 complement(1771143..1772267) 1 NC_003155.4 cysteine synthase/cystathionine beta-synthase family protein 1772267 cysK1 1213010 cysK1 Streptomyces avermitilis MA-4680 cysteine synthase/cystathionine beta-synthase family protein NP_822610.1 1771143 R 227882 CDS NP_822611.1 29827977 1213011 1772634..1772957 1 NC_003155.4 hypothetical protein 1772957 1213011 SAV_1436 Streptomyces avermitilis MA-4680 hypothetical protein NP_822611.1 1772634 D 227882 CDS NP_822612.1 29827978 1213012 1773206..1773721 1 NC_003155.4 regulatory protein 1773721 1213012 SAV_1437 Streptomyces avermitilis MA-4680 regulatory protein NP_822612.1 1773206 D 227882 CDS NP_822613.1 29827979 1213013 complement(1773932..1774243) 1 NC_003155.4 hypothetical protein 1774243 1213013 SAV_1438 Streptomyces avermitilis MA-4680 hypothetical protein NP_822613.1 1773932 R 227882 CDS NP_822614.1 29827980 1213014 1774392..1774967 1 NC_003155.4 TetR family transcriptional regulator 1774967 1213014 SAV_1439 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_822614.1 1774392 D 227882 CDS NP_822615.1 29827981 1213015 1775061..1775645 1 NC_003155.4 hypothetical protein 1775645 1213015 SAV_1440 Streptomyces avermitilis MA-4680 hypothetical protein NP_822615.1 1775061 D 227882 CDS NP_822616.1 29827982 1213016 1775639..1776550 1 NC_003155.4 phosphotriesterase-family protein 1776550 1213016 SAV_1441 Streptomyces avermitilis MA-4680 phosphotriesterase-family protein NP_822616.1 1775639 D 227882 CDS NP_822617.1 29827983 1213017 complement(1776636..1777880) 1 NC_003155.4 transcriptional regulator 1777880 1213017 SAV_1442 Streptomyces avermitilis MA-4680 transcriptional regulator NP_822617.1 1776636 R 227882 CDS NP_822618.1 29827984 1213018 complement(1778014..1778682) 1 NC_003155.4 alkylation damage repair; DNA repair protein 1778682 1213018 SAV_1443 Streptomyces avermitilis MA-4680 DNA repair protein NP_822618.1 1778014 R 227882 CDS NP_822619.1 29827985 1213019 1778763..1779905 1 NC_003155.4 ribosomal RNA small subunit methyltransferase 1779905 rsmC 1213019 rsmC Streptomyces avermitilis MA-4680 ribosomal RNA small subunit methyltransferase NP_822619.1 1778763 D 227882 CDS NP_822620.1 29827986 1210197 complement(1779895..1780800) 1 NC_003155.4 tagatose-bisphosphate aldolase 1780800 gatY 1210197 gatY Streptomyces avermitilis MA-4680 tagatose-bisphosphate aldolase NP_822620.1 1779895 R 227882 CDS NP_822621.1 29827987 1213020 complement(1780834..1781784) 1 NC_003155.4 PF01380: SIS domain; putave phosphosugar isomerase 1781784 1213020 SAV_1446 Streptomyces avermitilis MA-4680 putave phosphosugar isomerase NP_822621.1 1780834 R 227882 CDS NP_822622.1 29827988 1213021 1781851..1782630 1 NC_003155.4 DeoR family transcriptional regulator 1782630 1213021 SAV_1447 Streptomyces avermitilis MA-4680 DeoR family transcriptional regulator NP_822622.1 1781851 D 227882 CDS NP_822623.1 29827989 1213022 1782944..1783813 1 NC_003155.4 PF07728: ATPase family associated with various cellular activities (AAA); MoxR-like ATPase 1783813 1213022 SAV_1448 Streptomyces avermitilis MA-4680 MoxR-like ATPase NP_822623.1 1782944 D 227882 CDS NP_822624.1 29827990 1213023 1783810..1785183 1 NC_003155.4 PF05762: VWA domain containing CoxE-like protein; hypothetical protein 1785183 1213023 SAV_1449 Streptomyces avermitilis MA-4680 hypothetical protein NP_822624.1 1783810 D 227882 CDS NP_822625.1 29827991 1210198 1785294..1787336 1 NC_003155.4 alpha-glucuronidase 1787336 1210198 SAV_1450 Streptomyces avermitilis MA-4680 alpha-glucuronidase NP_822625.1 1785294 D 227882 CDS NP_822626.1 29827992 1210199 complement(1787385..1789421) 1 NC_003155.4 beta-galactosidase 1789421 bga3 1210199 bga3 Streptomyces avermitilis MA-4680 beta-galactosidase NP_822626.1 1787385 R 227882 CDS NP_822627.1 29827993 1213024 complement(1789418..1790179) 1 NC_003155.4 hypothetical protein 1790179 1213024 SAV_1452 Streptomyces avermitilis MA-4680 hypothetical protein NP_822627.1 1789418 R 227882 CDS NP_822628.1 29827994 1210200 complement(1790131..1791654) 1 NC_003155.4 xylan 1,4-beta-xylosidase 1791654 xynB1 1210200 xynB1 Streptomyces avermitilis MA-4680 xylan 1,4-beta-xylosidase NP_822628.1 1790131 R 227882 CDS NP_822629.1 29827995 1213025 complement(1791651..1793300) 1 NC_003155.4 ABC transporter substrate-binding protein 1793300 1213025 SAV_1454 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_822629.1 1791651 R 227882 CDS NP_822630.1 29827996 1213026 complement(1793336..1794262) 1 NC_003155.4 PF00528: Binding-protein-dependent transport system inner membrane component; ABC transporter permease 1794262 1213026 SAV_1455 Streptomyces avermitilis MA-4680 ABC transporter permease NP_822630.1 1793336 R 227882 CDS NP_822631.1 29827997 1210201 complement(1794256..1795254) 1 NC_003155.4 multiple sugar ABC transport permease 1795254 lplB 1210201 lplB Streptomyces avermitilis MA-4680 multiple sugar ABC transport permease NP_822631.1 1794256 R 227882 CDS NP_822632.1 29827998 1213027 1795541..1796542 1 NC_003155.4 PF05448: Acetyl xylan esterase (AXE1); acetyl xylan esterase 1796542 axe2 1213027 axe2 Streptomyces avermitilis MA-4680 acetyl xylan esterase NP_822632.1 1795541 D 227882 CDS NP_822633.1 29827999 1213028 complement(1796587..1797810) 1 NC_003155.4 PF00534: Glycosyl transferases group 1; glycosyl transferase 1797810 1213028 SAV_1458 Streptomyces avermitilis MA-4680 glycosyl transferase NP_822633.1 1796587 R 227882 CDS NP_822634.1 29828000 1213029 complement(1797842..1800043) 1 NC_003155.4 glycogen debranching enzyme 1800043 1213029 SAV_1459 Streptomyces avermitilis MA-4680 glycogen debranching enzyme NP_822634.1 1797842 R 227882 CDS NP_822635.1 29828001 1213030 1800284..1803319 1 NC_003155.4 ATP/GTP-binding protein 1803319 1213030 SAV_1460 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_822635.1 1800284 D 227882 CDS NP_822636.1 29828002 1213031 1803393..1804592 1 NC_003155.4 PF07690: Major Facilitator Superfamily; integral membrane transport protein 1804592 1213031 SAV_1461 Streptomyces avermitilis MA-4680 integral membrane transport protein NP_822636.1 1803393 D 227882 CDS NP_822637.1 29828003 1213032 complement(1804744..1805259) 1 NC_003155.4 MarR family transcriptional regulator 1805259 1213032 SAV_1463 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_822637.1 1804744 R 227882 CDS NP_822638.1 29828004 1213033 1805240..1806721 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 1806721 1213033 SAV_1462 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_822638.1 1805240 D 227882 CDS NP_822639.1 29828005 1213034 complement(1806823..1807488) 1 NC_003155.4 two-component system response regulator 1807488 1213034 SAV_1464 Streptomyces avermitilis MA-4680 two-component system response regulator NP_822639.1 1806823 R 227882 CDS NP_822640.1 29828006 1213035 complement(1807485..1808822) 1 NC_003155.4 two-component system sensor kinase 1808822 1213035 SAV_1465 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_822640.1 1807485 R 227882 CDS NP_822641.1 29828007 1213036 complement(1808928..1809578) 1 NC_003155.4 TetR family transcriptional regulator 1809578 1213036 SAV_1466 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_822641.1 1808928 R 227882 CDS NP_822642.1 29828008 1213037 1809764..1810807 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 1810807 1213037 SAV_1467 Streptomyces avermitilis MA-4680 dehydrogenase NP_822642.1 1809764 D 227882 CDS NP_822643.1 29828009 1213038 complement(1810861..1811595) 1 NC_003155.4 TetR family transcriptional regulator 1811595 1213038 SAV_1468 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_822643.1 1810861 R 227882 CDS NP_822644.1 29828010 1213039 1811682..1812233 1 NC_003155.4 PF04075: Domain of unknown function (DUF385); hypothetical protein 1812233 1213039 SAV_1469 Streptomyces avermitilis MA-4680 hypothetical protein NP_822644.1 1811682 D 227882 CDS NP_822645.1 29828011 1213040 complement(1812317..1813522) 1 NC_003155.4 hydrogenase 1813522 1213040 SAV_1470 Streptomyces avermitilis MA-4680 hydrogenase NP_822645.1 1812317 R 227882 CDS NP_822646.1 29828012 1213041 1813707..1815062 1 NC_003155.4 PF01546: Peptidase family M20/M25/M40; hypothetical protein 1815062 1213041 SAV_1471 Streptomyces avermitilis MA-4680 hypothetical protein NP_822646.1 1813707 D 227882 CDS NP_822647.1 29828013 1213042 1815103..1815852 1 NC_003155.4 PF00753: Metallo-beta-lactamase superfamily; metallo-beta-lactamase-like protein 1815852 1213042 SAV_1472 Streptomyces avermitilis MA-4680 metallo-beta-lactamase-like protein NP_822647.1 1815103 D 227882 CDS NP_822648.1 29828014 1213043 complement(1815974..1817014) 1 NC_003155.4 ATP/GTP-binding protein 1817014 1213043 SAV_1473 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_822648.1 1815974 R 227882 CDS NP_822649.1 29828015 1213044 complement(1817167..1817361) 1 NC_003155.4 protein 1817361 1213044 SAV_1474 Streptomyces avermitilis MA-4680 protein NP_822649.1 1817167 R 227882 CDS NP_822650.1 29828016 1210202 1817779..1819827 1 NC_003155.4 alpha-galactosidase 1819827 agaB2 1210202 agaB2 Streptomyces avermitilis MA-4680 alpha-galactosidase NP_822650.1 1817779 D 227882 CDS NP_822651.1 29828017 1213045 complement(1819858..1820817) 1 NC_003155.4 transcriptional regulator 1820817 1213045 SAV_1476 Streptomyces avermitilis MA-4680 transcriptional regulator NP_822651.1 1819858 R 227882 CDS NP_822652.1 29828018 1213046 1821069..1822106 1 NC_003155.4 LacI family transcriptional regulator 1822106 1213046 SAV_1477 Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_822652.1 1821069 D 227882 CDS NP_822653.1 29828019 1213047 complement(1822322..1823641) 1 NC_003155.4 hypothetical protein 1823641 1213047 SAV_1478 Streptomyces avermitilis MA-4680 hypothetical protein NP_822653.1 1822322 R 227882 CDS NP_822654.1 29828020 1213048 1823751..1824662 1 NC_003155.4 PF03372: Endonuclease/Exonuclease/phosphatase family; hypothetical protein 1824662 1213048 SAV_1479 Streptomyces avermitilis MA-4680 hypothetical protein NP_822654.1 1823751 D 227882 CDS NP_822655.1 29828021 1210203 complement(1824783..1825745) 1 NC_003155.4 electron transfer flavoprotein, alpha subunit 1825745 fixB 1210203 fixB Streptomyces avermitilis MA-4680 electron transfer flavoprotein, alpha subunit NP_822655.1 1824783 R 227882 CDS NP_822656.1 29828022 1210204 complement(1825800..1826594) 1 NC_003155.4 electron transfer flavoprotein, beta subunit 1826594 fixA 1210204 fixA Streptomyces avermitilis MA-4680 electron transfer flavoprotein, beta subunit NP_822656.1 1825800 R 227882 CDS NP_822657.1 29828023 1210205 complement(1826786..1827292) 1 NC_003155.4 flavin-dependent reductase 1827292 thiX1 1210205 thiX1 Streptomyces avermitilis MA-4680 flavin-dependent reductase NP_822657.1 1826786 R 227882 CDS NP_822658.1 29828024 1210206 complement(1827499..1827912) 1 NC_003155.4 thioredoxin 1827912 trxA4 1210206 trxA4 Streptomyces avermitilis MA-4680 thioredoxin NP_822658.1 1827499 R 227882 CDS NP_822659.1 29828025 1213049 1828015..1828431 1 NC_003155.4 hypothetical protein 1828431 1213049 SAV_1484 Streptomyces avermitilis MA-4680 hypothetical protein NP_822659.1 1828015 D 227882 CDS NP_822660.1 29828026 1210207 1828617..1829345 1 NC_003155.4 1-acylglycerol-3-phosphate O-acyltransferase 1829345 plsC1 1210207 plsC1 Streptomyces avermitilis MA-4680 1-acylglycerol-3-phosphate O-acyltransferase NP_822660.1 1828617 D 227882 CDS NP_822661.1 29828027 1213050 complement(1829350..1830042) 1 NC_003155.4 PF03483: B3/4 domain; hypothetical protein 1830042 1213050 SAV_1486 Streptomyces avermitilis MA-4680 hypothetical protein NP_822661.1 1829350 R 227882 CDS NP_822662.1 29828028 1213051 complement(1830057..1830656) 1 NC_003155.4 hypothetical protein 1830656 1213051 SAV_1487 Streptomyces avermitilis MA-4680 hypothetical protein NP_822662.1 1830057 R 227882 CDS NP_822663.1 29828029 1210208 complement(1830717..1831787) 1 NC_003155.4 L-threonine aldolase 1831787 ltaA 1210208 ltaA Streptomyces avermitilis MA-4680 L-threonine aldolase NP_822663.1 1830717 R 227882 CDS NP_822664.1 29828030 1213052 complement(1831784..1832530) 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 1832530 1213052 SAV_1489 Streptomyces avermitilis MA-4680 dehydrogenase NP_822664.1 1831784 R 227882 CDS NP_822665.1 29828031 1213053 complement(1832569..1833966) 1 NC_003155.4 hypothetical protein 1833966 1213053 SAV_1490 Streptomyces avermitilis MA-4680 hypothetical protein NP_822665.1 1832569 R 227882 CDS NP_822666.1 29828032 1213054 complement(1834048..1834539) 1 NC_003155.4 hypothetical protein 1834539 1213054 SAV_1491 Streptomyces avermitilis MA-4680 hypothetical protein NP_822666.1 1834048 R 227882 CDS NP_822667.1 29828033 1210209 1834659..1835342 1 NC_003155.4 glycerophosphoryl diester phosphodiesterase 1835342 glpQ5 1210209 glpQ5 Streptomyces avermitilis MA-4680 glycerophosphoryl diester phosphodiesterase NP_822667.1 1834659 D 227882 CDS NP_822668.1 29828034 1213055 complement(1835346..1835885) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 1835885 1213055 SAV_1493 Streptomyces avermitilis MA-4680 acetyltransferase NP_822668.1 1835346 R 227882 CDS NP_822669.1 29828035 1213056 1835957..1836349 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein 1836349 1213056 SAV_1494 Streptomyces avermitilis MA-4680 hypothetical protein NP_822669.1 1835957 D 227882 CDS NP_822670.1 29828036 1213057 1836411..1837175 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hydroxylase 1837175 1213057 SAV_1495 Streptomyces avermitilis MA-4680 hydroxylase NP_822670.1 1836411 D 227882 CDS NP_822671.1 29828037 1213058 complement(1837172..1837690) 1 NC_003155.4 PF00190: Cupin; hypothetical protein 1837690 1213058 SAV_1496 Streptomyces avermitilis MA-4680 hypothetical protein NP_822671.1 1837172 R 227882 CDS NP_822672.1 29828038 1213059 complement(1837808..1838404) 1 NC_003155.4 MarR family transcriptional regulator 1838404 1213059 SAV_1497 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_822672.1 1837808 R 227882 CDS NP_822673.1 29828039 1213060 complement(1838401..1840062) 1 NC_003155.4 integral membrane protein 1840062 1213060 SAV_1498 Streptomyces avermitilis MA-4680 integral membrane protein NP_822673.1 1838401 R 227882 CDS NP_822674.1 29828040 1213061 1840223..1840771 1 NC_003155.4 integral membrane protein 1840771 1213061 SAV_1499 Streptomyces avermitilis MA-4680 integral membrane protein NP_822674.1 1840223 D 227882 CDS NP_822675.1 29828041 1213062 1840948..1841883 1 NC_003155.4 PF01435: Peptidase family M48; integral membrane protein 1841883 1213062 SAV_1500 Streptomyces avermitilis MA-4680 integral membrane protein NP_822675.1 1840948 D 227882 CDS NP_822676.1 29828042 1213063 1841987..1842670 1 NC_003155.4 PF01569: PAP2 superfamily; hypothetical protein 1842670 1213063 SAV_1501 Streptomyces avermitilis MA-4680 hypothetical protein NP_822676.1 1841987 D 227882 CDS NP_822677.1 29828043 1213064 1842744..1843442 1 NC_003155.4 PF00702: haloacid dehalogenase-like hydrolase; hydrolase 1843442 1213064 SAV_1502 Streptomyces avermitilis MA-4680 hydrolase NP_822677.1 1842744 D 227882 CDS NP_822678.1 29828044 1213065 1843601..1844320 1 NC_003155.4 TetR family transcriptional regulator 1844320 1213065 SAV_1503 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_822678.1 1843601 D 227882 CDS NP_822679.1 29828045 1213066 complement(1844308..1845810) 1 NC_003155.4 protein 1845810 1213066 SAV_1504 Streptomyces avermitilis MA-4680 protein NP_822679.1 1844308 R 227882 CDS NP_822680.1 29828046 1213067 1845876..1846595 1 NC_003155.4 PF03713: Domain of unknown function (DUF305); lipoprotein 1846595 1213067 SAV_1505 Streptomyces avermitilis MA-4680 lipoprotein NP_822680.1 1845876 D 227882 CDS NP_822681.1 29828047 1213068 complement(1846605..1847069) 1 NC_003155.4 hypothetical protein 1847069 1213068 SAV_1506 Streptomyces avermitilis MA-4680 hypothetical protein NP_822681.1 1846605 R 227882 CDS NP_822682.1 29828048 1210210 1847273..1848619 1 NC_003155.4 NADPH-ferredoxin reductase 1848619 fprB 1210210 fprB Streptomyces avermitilis MA-4680 NADPH-ferredoxin reductase NP_822682.1 1847273 D 227882 CDS NP_822683.1 29828049 1210211 1848745..1850100 1 NC_003155.4 xanthine/uracil permease 1850100 pbuX1 1210211 pbuX1 Streptomyces avermitilis MA-4680 xanthine/uracil permease NP_822683.1 1848745 D 227882 CDS NP_822684.1 29828050 1213069 complement(1850086..1850445) 1 NC_003155.4 transcription regulator ArsR 1850445 1213069 SAV_1509 Streptomyces avermitilis MA-4680 transcription regulator ArsR NP_822684.1 1850086 R 227882 CDS NP_822685.1 29828051 1213070 1850562..1851641 1 NC_003155.4 PF00724: NADH:flavin oxidoreductase / NADH oxidase family; oxidoreductase 1851641 1213070 SAV_1510 Streptomyces avermitilis MA-4680 oxidoreductase NP_822685.1 1850562 D 227882 CDS NP_822686.1 29828052 1213071 complement(1851838..1852749) 1 NC_003155.4 sugar kinase 1852749 1213071 SAV_1511 Streptomyces avermitilis MA-4680 sugar kinase NP_822686.1 1851838 R 227882 CDS NP_822687.1 29828053 1213072 complement(1852830..1853459) 1 NC_003155.4 hypothetical protein 1853459 1213072 SAV_1512 Streptomyces avermitilis MA-4680 hypothetical protein NP_822687.1 1852830 R 227882 CDS NP_822688.1 29828054 1213073 1853697..1854839 1 NC_003155.4 PF02012: BNR/Asp-box repeat; hypothetical protein 1854839 1213073 SAV_1513 Streptomyces avermitilis MA-4680 hypothetical protein NP_822688.1 1853697 D 227882 CDS NP_822689.1 29828055 1210212 1855017..1856780 1 NC_003155.4 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 1856780 malS1 1210212 malS1 Streptomyces avermitilis MA-4680 malate dehydrogenase NP_822689.1 1855017 D 227882 CDS NP_822690.1 29828056 1213074 1856893..1857978 1 NC_003155.4 PF03547: Auxin Efflux Carrier; transport integral membrane protein 1857978 1213074 SAV_1515 Streptomyces avermitilis MA-4680 transport integral membrane protein NP_822690.1 1856893 D 227882 CDS NP_822691.1 29828057 1213075 1858078..1859835 1 NC_003155.4 PF05976: Bacterial membrane protein of unknown function (DUF893); integral membrane protein 1859835 1213075 SAV_1516 Streptomyces avermitilis MA-4680 integral membrane protein NP_822691.1 1858078 D 227882 CDS NP_822692.1 29828058 1213076 1859956..1860894 1 NC_003155.4 LysR family transcriptional regulator 1860894 1213076 SAV_1517 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_822692.1 1859956 D 227882 CDS NP_822693.1 29828059 1213077 complement(1860949..1861248) 1 NC_003155.4 hypothetical protein 1861248 1213077 SAV_1518 Streptomyces avermitilis MA-4680 hypothetical protein NP_822693.1 1860949 R 227882 CDS NP_822694.1 29828060 1213078 1861569..1862282 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 1862282 1213078 SAV_1519 Streptomyces avermitilis MA-4680 dehydrogenase NP_822694.1 1861569 D 227882 CDS NP_822695.1 29828061 1213079 1862701..1863681 1 NC_003155.4 catalyzes the formation of pyruvate from D-cysteine; D-cysteine desulfhydrase 1863681 1213079 SAV_1520 Streptomyces avermitilis MA-4680 D-cysteine desulfhydrase NP_822695.1 1862701 D 227882 CDS NP_822696.1 29828062 1213080 1863707..1864315 1 NC_003155.4 PF07336: Protein of unknown function (DUF1470); hypothetical protein 1864315 1213080 SAV_1521 Streptomyces avermitilis MA-4680 hypothetical protein NP_822696.1 1863707 D 227882 CDS NP_822697.1 29828063 1213081 1864635..1865171 1 NC_003155.4 epoxide hydrolase 1865171 1213081 SAV_1522 Streptomyces avermitilis MA-4680 epoxide hydrolase NP_822697.1 1864635 D 227882 CDS NP_822698.1 29828064 1213082 1865337..1865780 1 NC_003155.4 lyase 1865780 1213082 SAV_1523 Streptomyces avermitilis MA-4680 lyase NP_822698.1 1865337 D 227882 CDS NP_822699.1 29828065 1213083 complement(1865838..1866458) 1 NC_003155.4 TetR family transcriptional regulator 1866458 1213083 SAV_1524 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_822699.1 1865838 R 227882 CDS NP_822700.1 29828066 1213084 complement(1866759..1867412) 1 NC_003155.4 muconolactone delta-isomerase 1867412 1213084 SAV_1525 Streptomyces avermitilis MA-4680 muconolactone delta-isomerase NP_822700.1 1866759 R 227882 CDS NP_822701.1 29828067 1213085 1867505..1868419 1 NC_003155.4 LysR family transcriptional regulator 1868419 1213085 SAV_1526 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_822701.1 1867505 D 227882 CDS NP_822702.1 29828068 1210213 complement(1869096..1869773) 1 NC_003155.4 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 1869773 ung1 1210213 ung1 Streptomyces avermitilis MA-4680 uracil-DNA glycosylase NP_822702.1 1869096 R 227882 CDS NP_822703.1 29828069 1213086 1870024..1871082 1 NC_003155.4 PF01869: BadF/BadG/BcrA/BcrD ATPase family; hypothetical protein 1871082 1213086 SAV_1528 Streptomyces avermitilis MA-4680 hypothetical protein NP_822703.1 1870024 D 227882 CDS NP_822704.1 29828070 1213087 1871275..1872198 1 NC_003155.4 hypothetical protein 1872198 1213087 SAV_1529 Streptomyces avermitilis MA-4680 hypothetical protein NP_822704.1 1871275 D 227882 CDS NP_822705.1 29828071 1213088 complement(1872321..1873361) 1 NC_003155.4 protein 1873361 1213088 SAV_1530 Streptomyces avermitilis MA-4680 protein NP_822705.1 1872321 R 227882 CDS NP_822706.2 57833858 1213089 complement(1873463..1875013) 1 NC_003155.4 nitric oxide synthase 1875013 nos 1213089 nos Streptomyces avermitilis MA-4680 nitric oxide synthase NP_822706.2 1873463 R 227882 CDS NP_822707.1 29828073 1213090 complement(1875451..1877058) 1 NC_003155.4 hypothetical protein 1877058 1213090 SAV_7579 Streptomyces avermitilis MA-4680 hypothetical protein NP_822707.1 1875451 R 227882 CDS NP_822708.1 29828074 1213091 1877224..1877448 1 NC_003155.4 hypothetical protein 1877448 1213091 SAV_1532 Streptomyces avermitilis MA-4680 hypothetical protein NP_822708.1 1877224 D 227882 CDS NP_822709.1 29828075 1213092 complement(1877473..1877823) 1 NC_003155.4 PF03861: ANTAR domain; hypothetical protein 1877823 1213092 SAV_1533 Streptomyces avermitilis MA-4680 hypothetical protein NP_822709.1 1877473 R 227882 CDS NP_822710.1 29828076 1213093 1878051..1878527 1 NC_003155.4 transcription regulator AsnC 1878527 1213093 SAV_1534 Streptomyces avermitilis MA-4680 transcription regulator AsnC NP_822710.1 1878051 D 227882 CDS NP_822711.1 29828077 1213094 1878548..1879243 1 NC_003155.4 PF00702: haloacid dehalogenase-like hydrolase; hydrolase 1879243 1213094 SAV_1535 Streptomyces avermitilis MA-4680 hydrolase NP_822711.1 1878548 D 227882 CDS NP_822712.1 29828078 1213095 complement(1879347..1880507) 1 NC_003155.4 PF02625: XdhC and CoxI family; hypothetical protein 1880507 1213095 SAV_1536 Streptomyces avermitilis MA-4680 hypothetical protein NP_822712.1 1879347 R 227882 CDS NP_822713.1 29828079 1213096 complement(1880483..1882642) 1 NC_003155.4 frameshift; oxidoreductase 1882642 1213096 SAV_1538 Streptomyces avermitilis MA-4680 oxidoreductase NP_822713.1 1880483 R 227882 CDS NP_822714.1 29828080 1213097 complement(1880500..1881987) 1 NC_003155.4 frameshift, PF02738: Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding domain; oxidoreductase 1881987 1213097 SAV_1537 Streptomyces avermitilis MA-4680 oxidoreductase NP_822714.1 1880500 R 227882 CDS NP_822715.1 29828081 1213098 complement(1882639..1883631) 1 NC_003155.4 PF00941: FAD binding domain in molybdopterin dehydrogenase; oxidoreductase molybdopterin binding subunit 1883631 1213098 SAV_1539 Streptomyces avermitilis MA-4680 oxidoreductase molybdopterin binding subunit NP_822715.1 1882639 R 227882 CDS NP_822716.1 29828082 1210214 complement(1883628..1884200) 1 NC_003155.4 xanthine dehydrogenase 1884200 pucE 1210214 pucE Streptomyces avermitilis MA-4680 xanthine dehydrogenase NP_822716.1 1883628 R 227882 CDS NP_822717.1 29828083 1213099 1884456..1885052 1 NC_003155.4 TetR family transcriptional regulator 1885052 1213099 SAV_1541 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_822717.1 1884456 D 227882 CDS NP_822718.1 29828084 1213100 complement(1885125..1886015) 1 NC_003155.4 PF01210: NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; dehydrogenase 1886015 1213100 SAV_1542 Streptomyces avermitilis MA-4680 dehydrogenase NP_822718.1 1885125 R 227882 CDS NP_822719.1 29828085 1213101 complement(1886233..1887933) 1 NC_003155.4 hypothetical protein 1887933 1213101 SAV_1543 Streptomyces avermitilis MA-4680 hypothetical protein NP_822719.1 1886233 R 227882 CDS NP_822720.1 29828086 1213102 complement(1888040..1889335) 1 NC_003155.4 PF01757: Acyltransferase family; hypothetical protein 1889335 1213102 SAV_1544 Streptomyces avermitilis MA-4680 hypothetical protein NP_822720.1 1888040 R 227882 CDS NP_822721.1 29828087 1213103 complement(1889510..1890109) 1 NC_003155.4 hypothetical protein 1890109 1213103 SAV_1545 Streptomyces avermitilis MA-4680 hypothetical protein NP_822721.1 1889510 R 227882 CDS NP_822722.1 29828088 1213104 complement(1890201..1890755) 1 NC_003155.4 PF02627: Carboxymuconolactone decarboxylase family; hypothetical protein 1890755 1213104 SAV_1546 Streptomyces avermitilis MA-4680 hypothetical protein NP_822722.1 1890201 R 227882 CDS NP_822723.1 29828089 1210215 complement(1890784..1891254) 1 NC_003155.4 ribose-5-phosphate isomerase 1891254 rpiB1 1210215 rpiB1 Streptomyces avermitilis MA-4680 ribose-5-phosphate isomerase NP_822723.1 1890784 R 227882 CDS NP_822724.1 29828090 1213105 complement(1891269..1892069) 1 NC_003155.4 carboxylesterase 1892069 1213105 SAV_1548 Streptomyces avermitilis MA-4680 carboxylesterase NP_822724.1 1891269 R 227882 CDS NP_822725.1 29828091 1213106 complement(1892133..1893269) 1 NC_003155.4 esterase/lipase 1893269 1213106 SAV_1549 Streptomyces avermitilis MA-4680 esterase/lipase NP_822725.1 1892133 R 227882 CDS NP_822726.1 29828092 1213107 complement(1893266..1895794) 1 NC_003155.4 pks2 gene cluster; modular polyketide synthase 1895794 pks2-1 1213107 pks2-1 Streptomyces avermitilis MA-4680 modular polyketide synthase NP_822726.1 1893266 R 227882 CDS NP_822727.1 29828093 1213108 complement(1895828..1910257) 1 NC_003155.4 pks2 gene cluster; modular polyketide synthase 1910257 pks2-2 1213108 pks2-2 Streptomyces avermitilis MA-4680 modular polyketide synthase NP_822727.1 1895828 R 227882 CDS NP_822728.1 29828094 1213109 complement(1910558..1912282) 1 NC_003155.4 pks2 gene cluster; non-ribosomal peptide synthetase 1912282 pks2-3 1213109 pks2-3 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_822728.1 1910558 R 227882 CDS NP_822729.1 29828095 1213110 1912604..1913284 1 NC_003155.4 pks2 gene cluster; methyltransferase 1913284 1213110 SAV_1553 Streptomyces avermitilis MA-4680 methyltransferase NP_822729.1 1912604 D 227882 CDS NP_822730.1 29828096 1213111 1913338..1915320 1 NC_003155.4 PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; magnesium or manganese-dependent protein phosphatase 1915320 prpE1 1213111 prpE1 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_822730.1 1913338 D 227882 CDS NP_822731.1 29828097 1213112 complement(1915333..1916745) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; integral membrane protein 1916745 1213112 SAV_1555 Streptomyces avermitilis MA-4680 integral membrane protein NP_822731.1 1915333 R 227882 CDS NP_822732.1 29828098 1213113 1916763..1917722 1 NC_003155.4 AraC family transcription regulator 1917722 1213113 SAV_1556 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_822732.1 1916763 D 227882 CDS NP_822733.1 29828099 1213114 complement(1919349..1919771) 1 NC_003155.4 PF01894: Uncharacterised protein family UPF0047; hypothetical protein 1919771 1213114 SAV_1557 Streptomyces avermitilis MA-4680 hypothetical protein NP_822733.1 1919349 R 227882 CDS NP_822734.1 29828100 1213115 1920171..1920977 1 NC_003155.4 ABC transporter permease 1920977 1213115 SAV_1558 Streptomyces avermitilis MA-4680 ABC transporter permease NP_822734.1 1920171 D 227882 CDS NP_822735.1 29828101 1213116 1920950..1921732 1 NC_003155.4 ABC transporter ATP-binding protein 1921732 1213116 SAV_1559 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_822735.1 1920950 D 227882 CDS NP_822736.1 29828102 1213117 1921845..1922873 1 NC_003155.4 sulfonate binding protein precursor 1922873 1213117 SAV_1560 Streptomyces avermitilis MA-4680 sulfonate binding protein precursor NP_822736.1 1921845 D 227882 CDS NP_822737.1 29828103 1210216 1922873..1924027 1 NC_003155.4 PF00296: Luciferase-like monooxygenase; alkanesulfonate monooxygenase 1924027 ssuD2 1210216 ssuD2 Streptomyces avermitilis MA-4680 alkanesulfonate monooxygenase NP_822737.1 1922873 D 227882 CDS NP_822738.1 29828104 1213118 1924069..1925157 1 NC_003155.4 PF00070: Pyridine nucleotide-disulphide oxidoreductase; oxidoreductase 1925157 1213118 SAV_1562 Streptomyces avermitilis MA-4680 oxidoreductase NP_822738.1 1924069 D 227882 CDS NP_822739.1 29828105 1210217 complement(1925174..1926019) 1 NC_003155.4 aminodeoxychorismate lyase 1926019 pabC 1210217 pabC Streptomyces avermitilis MA-4680 aminodeoxychorismate lyase NP_822739.1 1925174 R 227882 CDS NP_822740.1 29828106 1213119 complement(1926063..1927862) 1 NC_003155.4 ABC transporter ATP-binding protein 1927862 1213119 SAV_1564 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_822740.1 1926063 R 227882 CDS NP_822741.1 29828107 1213120 1927957..1928412 1 NC_003155.4 MarR family transcriptional regulator 1928412 1213120 SAV_1565 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_822741.1 1927957 D 227882 CDS NP_822742.1 29828108 1213121 complement(1928740..1928997) 1 NC_003155.4 hypothetical protein 1928997 1213121 SAV_1566 Streptomyces avermitilis MA-4680 hypothetical protein NP_822742.1 1928740 R 227882 CDS NP_822743.1 29828109 1213122 complement(1929019..1930644) 1 NC_003155.4 hypothetical protein 1930644 1213122 SAV_1567 Streptomyces avermitilis MA-4680 hypothetical protein NP_822743.1 1929019 R 227882 CDS NP_822744.1 29828110 1213123 complement(1930839..1931663) 1 NC_003155.4 lipoprotein 1931663 1213123 SAV_1568 Streptomyces avermitilis MA-4680 lipoprotein NP_822744.1 1930839 R 227882 CDS NP_822745.1 29828111 1213124 1931874..1933736 1 NC_003155.4 hypothetical protein 1933736 1213124 SAV_1569 Streptomyces avermitilis MA-4680 hypothetical protein NP_822745.1 1931874 D 227882 CDS NP_822746.1 29828112 1213125 1933733..1935514 1 NC_003155.4 ABC transporter ATP-binding protein 1935514 1213125 SAV_1570 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_822746.1 1933733 D 227882 CDS NP_822747.1 29828113 1213126 1936091..1936561 1 NC_003155.4 hypothetical protein 1936561 1213126 SAV_1571 Streptomyces avermitilis MA-4680 hypothetical protein NP_822747.1 1936091 D 227882 CDS NP_822748.1 29828114 1210218 1936716..1936991 1 NC_003155.4 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 type B 1936991 rpmE2 1210218 rpmE2 Streptomyces avermitilis MA-4680 50S ribosomal protein L31 type B NP_822748.1 1936716 D 227882 CDS NP_822749.1 29828115 1213127 complement(1937072..1937866) 1 NC_003155.4 PF04307: Predicted membrane-bound metal-dependent hydrolase (DUF457); integral membrane protein 1937866 1213127 SAV_1574 Streptomyces avermitilis MA-4680 integral membrane protein NP_822749.1 1937072 R 227882 CDS NP_822750.1 29828116 1213128 1937865..1940525 1 NC_003155.4 PF00270: DEAD/DEAH box helicase; ATP-dependent helicase 1940525 1213128 SAV_1573 Streptomyces avermitilis MA-4680 ATP-dependent helicase NP_822750.1 1937865 D 227882 CDS NP_822751.1 29828117 1210219 1940545..1941411 1 NC_003155.4 PF02551: Acyl-CoA thioesterase; acyl-CoA thioesterase 1941411 tesB1 1210219 tesB1 Streptomyces avermitilis MA-4680 acyl-CoA thioesterase NP_822751.1 1940545 D 227882 CDS NP_822752.1 29828118 1213129 complement(1941471..1942481) 1 NC_003155.4 hypothetical protein 1942481 1213129 SAV_1576 Streptomyces avermitilis MA-4680 hypothetical protein NP_822752.1 1941471 R 227882 CDS NP_822753.1 29828119 1213130 complement(1942608..1943024) 1 NC_003155.4 PF03259: Roadblock/LC7 domain; hypothetical protein 1943024 1213130 SAV_1577 Streptomyces avermitilis MA-4680 hypothetical protein NP_822753.1 1942608 R 227882 CDS NP_822754.1 29828120 1213131 1943111..1943548 1 NC_003155.4 PF01243: Pyridoxamine 5'-phosphate oxidase; hypothetical protein 1943548 1213131 SAV_1578 Streptomyces avermitilis MA-4680 hypothetical protein NP_822754.1 1943111 D 227882 CDS NP_822755.1 29828121 1210220 complement(1943568..1944173) 1 NC_003155.4 multi-component regulatory system-2; ATP/GTP-binding protein 1944173 cvnD2 1210220 cvnD2 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_822755.1 1943568 R 227882 CDS NP_822756.1 29828122 1210221 complement(1944205..1944618) 1 NC_003155.4 multi-component regulatory system-2, PF05331: Protein of unknown function (DUF742); hypothetical protein 1944618 cvnC2 1210221 cvnC2 Streptomyces avermitilis MA-4680 hypothetical protein NP_822756.1 1944205 R 227882 CDS NP_822757.1 29828123 1210222 complement(1944638..1945075) 1 NC_003155.4 multi-component regulatory system-2, PF03259: Roadblock/LC7 domain; hypothetical protein 1945075 cvnB2 1210222 cvnB2 Streptomyces avermitilis MA-4680 hypothetical protein NP_822757.1 1944638 R 227882 CDS NP_822758.1 29828124 1210223 complement(1945072..1947624) 1 NC_003155.4 multi-component regulatory system-2; sensor-like histidine kinase 1947624 cvnA2 1210223 cvnA2 Streptomyces avermitilis MA-4680 sensor-like histidine kinase NP_822758.1 1945072 R 227882 CDS NP_822759.1 29828125 1213132 complement(1947688..1948419) 1 NC_003155.4 PF03707: Bacterial signalling protein N terminal repeat; integral membrane protein 1948419 1213132 SAV_1583 Streptomyces avermitilis MA-4680 integral membrane protein NP_822759.1 1947688 R 227882 CDS NP_822760.1 29828126 1213133 1948605..1949213 1 NC_003155.4 methyltransferase 1949213 1213133 SAV_1584 Streptomyces avermitilis MA-4680 methyltransferase NP_822760.1 1948605 D 227882 CDS NP_822761.1 29828127 1213134 complement(1949240..1949998) 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hypothetical protein 1949998 1213134 SAV_1585 Streptomyces avermitilis MA-4680 hypothetical protein NP_822761.1 1949240 R 227882 CDS NP_822762.1 29828128 1213135 1950129..1950671 1 NC_003155.4 PadR-like family transcriptional regulator 1950671 1213135 SAV_1586 Streptomyces avermitilis MA-4680 PadR-like family transcriptional regulator NP_822762.1 1950129 D 227882 CDS NP_822763.1 29828129 1213136 complement(1950648..1951553) 1 NC_003155.4 hypothetical protein 1951553 1213136 SAV_1587 Streptomyces avermitilis MA-4680 hypothetical protein NP_822763.1 1950648 R 227882 CDS NP_822764.1 29828130 1213137 1951608..1951949 1 NC_003155.4 hypothetical protein 1951949 1213137 SAV_1588 Streptomyces avermitilis MA-4680 hypothetical protein NP_822764.1 1951608 D 227882 CDS NP_822765.1 29828131 1213138 1952105..1952986 1 NC_003155.4 hypothetical protein 1952986 1213138 SAV_1589 Streptomyces avermitilis MA-4680 hypothetical protein NP_822765.1 1952105 D 227882 CDS NP_822766.1 29828132 1213139 complement(1953112..1953348) 1 NC_003155.4 hypothetical protein 1953348 1213139 SAV_1590 Streptomyces avermitilis MA-4680 hypothetical protein NP_822766.1 1953112 R 227882 CDS NP_822767.1 29828133 1210224 complement(1953419..1954480) 1 NC_003155.4 PF00487: Fatty acid desaturase; delta-6 fatty acid desaturase 1954480 fadS1 1210224 fadS1 Streptomyces avermitilis MA-4680 delta-6 fatty acid desaturase NP_822767.1 1953419 R 227882 CDS NP_822768.1 29828134 1210225 1954746..1957685 1 NC_003155.4 SNF2/RAD54 family helicase 1957685 helZ2 1210225 helZ2 Streptomyces avermitilis MA-4680 SNF2/RAD54 family helicase NP_822768.1 1954746 D 227882 CDS NP_822769.1 29828135 1213140 1957682..1958959 1 NC_003155.4 hypothetical protein 1958959 1213140 SAV_1593 Streptomyces avermitilis MA-4680 hypothetical protein NP_822769.1 1957682 D 227882 CDS NP_822770.1 29828136 1213141 complement(1959084..1960367) 1 NC_003155.4 hypothetical protein 1960367 1213141 SAV_1594 Streptomyces avermitilis MA-4680 hypothetical protein NP_822770.1 1959084 R 227882 CDS NP_822771.1 29828137 1213142 complement(1960490..1962097) 1 NC_003155.4 initiates steroid ring degradation; catalyzes the transhydrogenation of 3-keto-4-ene-steroid to 3-keto-1,4-diene-steroid e.g., progesterone to 1,4-androstadiene-3,17-dione; 3-ketosteroid-delta-1-dehydrogenase 1962097 1213142 SAV_1595 Streptomyces avermitilis MA-4680 3-ketosteroid-delta-1-dehydrogenase NP_822771.1 1960490 R 227882 CDS NP_822772.1 29828138 1213143 1962456..1962950 1 NC_003155.4 hypothetical protein 1962950 1213143 SAV_1596 Streptomyces avermitilis MA-4680 hypothetical protein NP_822772.1 1962456 D 227882 CDS NP_822773.1 29828139 1213144 complement(1963035..1964003) 1 NC_003155.4 PF00248: Aldo/keto reductase family; oxidoreductase 1964003 1213144 SAV_1597 Streptomyces avermitilis MA-4680 oxidoreductase NP_822773.1 1963035 R 227882 CDS NP_822774.1 29828140 1213145 1964411..1965265 1 NC_003155.4 PF00656: Caspase domain; hypothetical protein 1965265 1213145 SAV_1598 Streptomyces avermitilis MA-4680 hypothetical protein NP_822774.1 1964411 D 227882 CDS NP_822775.1 29828141 1213146 1965484..1966050 1 NC_003155.4 PF03745: Domain of unknown function (DUF309); hypothetical protein 1966050 1213146 SAV_1599 Streptomyces avermitilis MA-4680 hypothetical protein NP_822775.1 1965484 D 227882 CDS NP_822776.1 29828142 1213147 1966110..1966880 1 NC_003155.4 catalyzes the formation of precorrin 6x from precorrin 5; precorrin 6A synthase 1966880 cobF 1213147 cobF Streptomyces avermitilis MA-4680 precorrin 6A synthase NP_822776.1 1966110 D 227882 CDS NP_822777.1 29828143 1213148 complement(1967656..1968402) 1 NC_003155.4 CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6; cobalt-precorrin-6x reductase 1968402 cobK 1213148 cobK Streptomyces avermitilis MA-4680 cobalt-precorrin-6x reductase NP_822777.1 1967656 R 227882 CDS NP_822778.1 29828144 1213149 complement(1968424..1969197) 1 NC_003155.4 PF01925: Domain of unknown function DUF81; integral membrane protein 1969197 1213149 SAV_1602 Streptomyces avermitilis MA-4680 integral membrane protein NP_822778.1 1968424 R 227882 CDS NP_822779.1 29828145 1210227 complement(1969300..1970811) 1 NC_003155.4 PF00501: AMP-binding enzyme; acyl-CoA synthetase, long-chain fatty acid:CoA ligase 1970811 fadD7 1210227 fadD7 Streptomyces avermitilis MA-4680 acyl-CoA synthetase, long-chain fatty acid:CoA ligase NP_822779.1 1969300 R 227882 CDS NP_822780.1 29828146 1210228 complement(1970941..1972128) 1 NC_003155.4 PF00108: Thiolase, N-terminal domain; beta-ketoadipyl-CoA thiolase 1972128 pcaF1 1210228 pcaF1 Streptomyces avermitilis MA-4680 beta-ketoadipyl-CoA thiolase NP_822780.1 1970941 R 227882 CDS NP_822781.1 29828147 1213150 1972321..1972803 1 NC_003155.4 PF00210: ferritin-like domain; starvation-induced DNA protecting protein 1972803 mrgA1 1213150 mrgA1 Streptomyces avermitilis MA-4680 starvation-induced DNA protecting protein NP_822781.1 1972321 D 227882 CDS NP_822782.1 29828148 1213151 1972823..1973470 1 NC_003155.4 PF00730: HhH-GPD superfamily base excision DNA repair protein; endonuclease III-like protein 1973470 1213151 SAV_1606 Streptomyces avermitilis MA-4680 endonuclease III-like protein NP_822782.1 1972823 D 227882 CDS NP_822783.1 29828149 1213152 1973812..1975050 1 NC_003155.4 PF01594: Domain of unknown function DUF20; integral membrane protein 1975050 1213152 SAV_1607 Streptomyces avermitilis MA-4680 integral membrane protein NP_822783.1 1973812 D 227882 CDS NP_822784.1 29828150 1213153 complement(1975282..1975818) 1 NC_003155.4 MarR family transcriptional regulator 1975818 1213153 SAV_1608 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_822784.1 1975282 R 227882 CDS NP_822785.1 29828151 1210229 complement(1975840..1977057) 1 NC_003155.4 ferredoxin reductase 1977057 fprC 1210229 fprC Streptomyces avermitilis MA-4680 ferredoxin reductase NP_822785.1 1975840 R 227882 CDS NP_822786.1 29828152 1210230 complement(1977054..1977251) 1 NC_003155.4 ferredoxin 1977251 fdxB 1210230 fdxB Streptomyces avermitilis MA-4680 ferredoxin NP_822786.1 1977054 R 227882 CDS NP_822787.1 29828153 1210231 complement(1977286..1978527) 1 NC_003155.4 CYP105Q1, fdxB and fprC are located at downstream; cytochrome P450 1978527 cyp7 1210231 cyp7 Streptomyces avermitilis MA-4680 cytochrome P450 NP_822787.1 1977286 R 227882 CDS NP_822788.1 29828154 1213154 complement(1978871..1979575) 1 NC_003155.4 two-component system response regulator 1979575 1213154 SAV_1612 Streptomyces avermitilis MA-4680 two-component system response regulator NP_822788.1 1978871 R 227882 CDS NP_822789.1 29828155 1213155 1979878..1980648 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 1980648 1213155 SAV_1613 Streptomyces avermitilis MA-4680 dehydrogenase NP_822789.1 1979878 D 227882 CDS NP_822790.1 29828156 1213156 complement(1980949..1982277) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; benzoate transport protein 1982277 1213156 SAV_1614 Streptomyces avermitilis MA-4680 benzoate transport protein NP_822790.1 1980949 R 227882 CDS NP_822791.1 29828157 1210232 complement(1982532..1983482) 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; catechol 2,3-dioxygenase 1983482 xylE 1210232 xylE Streptomyces avermitilis MA-4680 catechol 2,3-dioxygenase NP_822791.1 1982532 R 227882 CDS NP_822792.1 29828158 1213157 complement(1983493..1984566) 1 NC_003155.4 transmenmbrane protein 1984566 1213157 SAV_1616 Streptomyces avermitilis MA-4680 transmenmbrane protein NP_822792.1 1983493 R 227882 CDS NP_822793.1 29828159 1213158 complement(1984590..1985300) 1 NC_003155.4 hypothetical protein 1985300 1213158 SAV_1617 Streptomyces avermitilis MA-4680 hypothetical protein NP_822793.1 1984590 R 227882 CDS NP_822794.1 29828160 1213159 complement(1985297..1986046) 1 NC_003155.4 PF02585: Uncharacterised LmbE-like protein, COG2120; hypothetical protein 1986046 1213159 SAV_1618 Streptomyces avermitilis MA-4680 hypothetical protein NP_822794.1 1985297 R 227882 CDS NP_822795.1 29828161 1213160 complement(1986092..1986742) 1 NC_003155.4 GntR family transcriptional regulator 1986742 1213160 SAV_1619 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_822795.1 1986092 R 227882 CDS NP_822796.1 29828162 1213161 complement(1987073..1988569) 1 NC_003155.4 amino acid permease 1988569 1213161 SAV_1620 Streptomyces avermitilis MA-4680 amino acid permease NP_822796.1 1987073 R 227882 CDS NP_822797.1 29828163 1213162 complement(1988569..1990113) 1 NC_003155.4 PF00732: GMC oxidoreductase; oxidoreductase 1990113 1213162 SAV_1621 Streptomyces avermitilis MA-4680 oxidoreductase NP_822797.1 1988569 R 227882 CDS NP_822798.1 29828164 1210233 complement(1990145..1991611) 1 NC_003155.4 glycine betaine aldehyde dehydrogenase 1991611 gbsA1 1210233 gbsA1 Streptomyces avermitilis MA-4680 glycine betaine aldehyde dehydrogenase NP_822798.1 1990145 R 227882 CDS NP_822799.1 29828165 1213163 1992287..1992997 1 NC_003155.4 transketolase A subunit 1992997 1213163 SAV_1623 Streptomyces avermitilis MA-4680 transketolase A subunit NP_822799.1 1992287 D 227882 CDS NP_822800.1 29828166 1213164 1993096..1994007 1 NC_003155.4 transketolase B subunit 1994007 1213164 SAV_1624 Streptomyces avermitilis MA-4680 transketolase B subunit NP_822800.1 1993096 D 227882 CDS NP_822801.1 29828167 1213165 complement(1994047..1994535) 1 NC_003155.4 PF04944: Uncharacterised BCR (COG3801); hypothetical protein 1994535 1213165 SAV_1625 Streptomyces avermitilis MA-4680 hypothetical protein NP_822801.1 1994047 R 227882 CDS NP_822802.1 29828168 1213166 complement(1994576..1995481) 1 NC_003155.4 LysR family transcriptional regulator 1995481 1213166 SAV_1626 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_822802.1 1994576 R 227882 CDS NP_822803.1 29828169 1210235 complement(1995767..1996963) 1 NC_003155.4 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate coenzyme A ligase 1996963 kbl 1210235 kbl Streptomyces avermitilis MA-4680 2-amino-3-ketobutyrate coenzyme A ligase NP_822803.1 1995767 R 227882 CDS NP_822804.1 29828170 1210236 complement(1996980..1998008) 1 NC_003155.4 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase 1998008 tdh 1210236 tdh Streptomyces avermitilis MA-4680 L-threonine 3-dehydrogenase NP_822804.1 1996980 R 227882 CDS NP_822805.1 29828171 1213167 complement(1998258..1998839) 1 NC_003155.4 PF01590: GAF domain; hypothetical protein 1998839 1213167 SAV_1629 Streptomyces avermitilis MA-4680 hypothetical protein NP_822805.1 1998258 R 227882 CDS NP_822806.1 29828172 1210237 complement(1998868..1999416) 1 NC_003155.4 multi-component regulatory system-3; ATP/GTP-binding protein 1999416 cvnD3 1210237 cvnD3 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_822806.1 1998868 R 227882 CDS NP_822807.1 29828173 1210238 complement(1999445..1999765) 1 NC_003155.4 multi-component regulatory system-3, PF05331: Protein of unknown function (DUF742); hypothetical protein 1999765 cvnC3 1210238 cvnC3 Streptomyces avermitilis MA-4680 hypothetical protein NP_822807.1 1999445 R 227882 CDS NP_822808.1 29828174 1210239 complement(1999819..2000253) 1 NC_003155.4 multi-component regulatory system-3, PF03259: Roadblock/LC7 domain; hypothetical protein 2000253 cvnB3 1210239 cvnB3 Streptomyces avermitilis MA-4680 hypothetical protein NP_822808.1 1999819 R 227882 CDS NP_822809.1 29828175 1210240 complement(2000524..2002077) 1 NC_003155.4 multi-component regulatory system-3; sensor-like histidine kinase 2002077 cvnA3 1210240 cvnA3 Streptomyces avermitilis MA-4680 sensor-like histidine kinase NP_822809.1 2000524 R 227882 CDS NP_822810.1 29828176 1213168 complement(2002445..2003665) 1 NC_003155.4 PF00753: Metallo-beta-lactamase superfamily; hypothetical protein 2003665 1213168 SAV_1634 Streptomyces avermitilis MA-4680 hypothetical protein NP_822810.1 2002445 R 227882 CDS NP_822811.1 29828177 1213169 2003675..2004457 1 NC_003155.4 PF02627: Carboxymuconolactone decarboxylase family; hypothetical protein 2004457 1213169 SAV_1635 Streptomyces avermitilis MA-4680 hypothetical protein NP_822811.1 2003675 D 227882 CDS NP_822812.1 29828178 1210241 2004635..2005813 1 NC_003155.4 glutamate dehydrogenase 2005813 rocG 1210241 rocG Streptomyces avermitilis MA-4680 glutamate dehydrogenase NP_822812.1 2004635 D 227882 CDS NP_822813.1 29828179 1213170 2005912..2006532 1 NC_003155.4 TetR family transcriptional regulator 2006532 1213170 SAV_1637 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_822813.1 2005912 D 227882 CDS NP_822814.1 29828180 1213171 complement(2006611..2007396) 1 NC_003155.4 PF00657: GDSL-like Lipase/Acylhydrolase; hypothetical protein 2007396 1213171 SAV_1638 Streptomyces avermitilis MA-4680 hypothetical protein NP_822814.1 2006611 R 227882 CDS NP_822815.1 29828181 1213172 complement(2007541..2008260) 1 NC_003155.4 hypothetical protein 2008260 1213172 SAV_1639 Streptomyces avermitilis MA-4680 hypothetical protein NP_822815.1 2007541 R 227882 CDS NP_822816.1 29828182 1213173 complement(2008712..2009617) 1 NC_003155.4 PF01551: Peptidase family M23; peptidase 2009617 1213173 SAV_1640 Streptomyces avermitilis MA-4680 peptidase NP_822816.1 2008712 R 227882 CDS NP_822817.1 29828183 1210242 complement(2010083..2012185) 1 NC_003155.4 alpha-galactosidase 2012185 agaB3 1210242 agaB3 Streptomyces avermitilis MA-4680 alpha-galactosidase NP_822817.1 2010083 R 227882 CDS NP_822818.1 29828184 1213174 2012323..2013120 1 NC_003155.4 conventional protein tyrosine phosphatase 2013120 ptpA2 1213174 ptpA2 Streptomyces avermitilis MA-4680 conventional protein tyrosine phosphatase NP_822818.1 2012323 D 227882 CDS NP_822819.1 29828185 1213175 complement(2013146..2013340) 1 NC_003155.4 small hydrophobic protein 2013340 1213175 SAV_1643 Streptomyces avermitilis MA-4680 small hydrophobic protein NP_822819.1 2013146 R 227882 CDS NP_822820.1 29828186 1213176 complement(2013292..2013918) 1 NC_003155.4 regulatory protein 2013918 1213176 SAV_1644 Streptomyces avermitilis MA-4680 regulatory protein NP_822820.1 2013292 R 227882 CDS NP_822821.1 29828187 1213177 complement(2014006..2015436) 1 NC_003155.4 aminotransferase 2015436 1213177 SAV_1645 Streptomyces avermitilis MA-4680 aminotransferase NP_822821.1 2014006 R 227882 CDS NP_822822.1 29828188 1210243 complement(2015433..2017331) 1 NC_003155.4 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 2017331 dxs1 1210243 dxs1 Streptomyces avermitilis MA-4680 1-deoxy-D-xylulose-5-phosphate synthase NP_822822.1 2015433 R 227882 CDS NP_822823.1 29828189 1210244 complement(2017360..2018517) 1 NC_003155.4 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 2018517 ispG 1210244 ispG Streptomyces avermitilis MA-4680 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase NP_822823.1 2017360 R 227882 CDS NP_822824.1 29828190 1213178 complement(2018522..2019544) 1 NC_003155.4 PF04055: radical SAM superfamily domain; hypothetical protein 2019544 1213178 SAV_1648 Streptomyces avermitilis MA-4680 hypothetical protein NP_822824.1 2018522 R 227882 CDS NP_822825.1 29828191 1213179 complement(2019550..2020194) 1 NC_003155.4 PF01048: Phosphorylase family; hypothetical protein 2020194 1213179 SAV_1649 Streptomyces avermitilis MA-4680 hypothetical protein NP_822825.1 2019550 R 227882 CDS NP_822826.1 29828192 1210245 complement(2020191..2022191) 1 NC_003155.4 squalene/hopene gene cluster, shc; squalene-hopene cyclase 2022191 hopA 1210245 hopA Streptomyces avermitilis MA-4680 squalene-hopene cyclase NP_822826.1 2020191 R 227882 CDS NP_822827.1 29828193 1210246 complement(2022306..2023436) 1 NC_003155.4 squalene/hopene gene cluster, probably farnesyl pyrophosphate synthase; polyprenyl diphosphate synthase 2023436 hopB 1210246 hopB Streptomyces avermitilis MA-4680 polyprenyl diphosphate synthase NP_822827.1 2022306 R 227882 CDS NP_822828.1 29828194 1210247 complement(2023433..2024860) 1 NC_003155.4 squalene/hopene gene cluster, sqd; squalene/phytoene dehydrogenase 2024860 hopC 1210247 hopC Streptomyces avermitilis MA-4680 squalene/phytoene dehydrogenase NP_822828.1 2023433 R 227882 CDS NP_822829.1 29828195 1210248 complement(2024997..2025947) 1 NC_003155.4 squalene/hopene gene cluster, sqs1; squalene/phytoene synthase 2025947 hopD 1210248 hopD Streptomyces avermitilis MA-4680 squalene/phytoene synthase NP_822829.1 2024997 R 227882 CDS NP_822830.1 29828196 1210249 complement(2025944..2026846) 1 NC_003155.4 squalene/hopene gene cluster, sqs2; squalene/phytoene synthase 2026846 hopE 1210249 hopE Streptomyces avermitilis MA-4680 squalene/phytoene synthase NP_822830.1 2025944 R 227882 CDS NP_822831.1 29828197 1213180 complement(2027207..2027986) 1 NC_003155.4 ABC transporter ATP-binding protein 2027986 1213180 SAV_1655 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_822831.1 2027207 R 227882 CDS NP_822832.1 29828198 1213181 complement(2027979..2028908) 1 NC_003155.4 ABC transporter permease 2028908 1213181 SAV_1656 Streptomyces avermitilis MA-4680 ABC transporter permease NP_822832.1 2027979 R 227882 CDS NP_822833.1 29828199 1213182 complement(2029006..2029890) 1 NC_003155.4 glycosyltransferase 2029890 1213182 SAV_1657 Streptomyces avermitilis MA-4680 glycosyltransferase NP_822833.1 2029006 R 227882 CDS NP_822834.1 29828200 1213183 complement(2029887..2030570) 1 NC_003155.4 transferase 2030570 1213183 SAV_1658 Streptomyces avermitilis MA-4680 transferase NP_822834.1 2029887 R 227882 CDS NP_822835.1 29828201 1210250 complement(2030644..2031705) 1 NC_003155.4 glycerol 1-phosphate dehydrogenase 2031705 gldA 1210250 gldA Streptomyces avermitilis MA-4680 glycerol 1-phosphate dehydrogenase NP_822835.1 2030644 R 227882 CDS NP_822836.1 29828202 1213184 complement(2031693..2032445) 1 NC_003155.4 nucleotide sugar-1-phosphate transferase 2032445 1213184 SAV_1660 Streptomyces avermitilis MA-4680 nucleotide sugar-1-phosphate transferase NP_822836.1 2031693 R 227882 CDS NP_822837.1 29828203 1213185 complement(2032442..2034163) 1 NC_003155.4 transferase 2034163 1213185 SAV_1661 Streptomyces avermitilis MA-4680 transferase NP_822837.1 2032442 R 227882 CDS NP_822838.1 29828204 1210251 2034577..2035557 1 NC_003155.4 UDP-glucose 4-epimerase 2035557 galE6 1210251 galE6 Streptomyces avermitilis MA-4680 UDP-glucose 4-epimerase NP_822838.1 2034577 D 227882 CDS NP_822839.1 29828205 1210252 2035914..2036507 1 NC_003155.4 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 2036507 idi 1210252 idi Streptomyces avermitilis MA-4680 isopentenyl-diphosphate delta-isomerase NP_822839.1 2035914 D 227882 CDS NP_822840.1 29828206 1213186 complement(2036581..2037156) 1 NC_003155.4 regulatory protein 2037156 1213186 SAV_1664 Streptomyces avermitilis MA-4680 regulatory protein NP_822840.1 2036581 R 227882 CDS NP_822841.1 29828207 1210253 2037350..2038099 1 NC_003155.4 enoyl-CoA hydratase 2038099 echA6 1210253 echA6 Streptomyces avermitilis MA-4680 enoyl-CoA hydratase NP_822841.1 2037350 D 227882 CDS NP_822842.1 29828208 1210254 complement(2038086..2038721) 1 NC_003155.4 4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme 2038721 thiJ 1210254 thiJ Streptomyces avermitilis MA-4680 4-methyl-5(B-hydroxyethyl)-thiazole monophosphate biosynthesis enzyme NP_822842.1 2038086 R 227882 CDS NP_822843.1 29828209 1213187 complement(2038747..2039751) 1 NC_003155.4 AraC family transcription regulator 2039751 1213187 SAV_1667 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_822843.1 2038747 R 227882 CDS NP_822844.1 29828210 1213188 2039912..2040679 1 NC_003155.4 hypothetical protein 2040679 1213188 SAV_1668 Streptomyces avermitilis MA-4680 hypothetical protein NP_822844.1 2039912 D 227882 CDS NP_822845.1 29828211 1213189 2040961..2043393 1 NC_003155.4 transcription accessory protein 2043393 1213189 SAV_1669 Streptomyces avermitilis MA-4680 transcription accessory protein NP_822845.1 2040961 D 227882 CDS NP_822846.1 29828212 1213190 complement(2043550..2045190) 1 NC_003155.4 ABC transporter ATP-binding protein 2045190 1213190 SAV_1670 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_822846.1 2043550 R 227882 CDS NP_822847.1 29828213 1213191 complement(2045266..2046285) 1 NC_003155.4 oxidoreductase 2046285 1213191 SAV_1671 Streptomyces avermitilis MA-4680 oxidoreductase NP_822847.1 2045266 R 227882 CDS NP_822848.1 29828214 1210255 2046352..2047305 1 NC_003155.4 D-amino acid oxidase 2047305 dao 1210255 dao Streptomyces avermitilis MA-4680 D-amino acid oxidase NP_822848.1 2046352 D 227882 CDS NP_822849.1 29828215 1213192 complement(2047310..2048605) 1 NC_003155.4 PF00246: Zinc carboxypeptidase; carboxypeptidase 2048605 1213192 SAV_1673 Streptomyces avermitilis MA-4680 carboxypeptidase NP_822849.1 2047310 R 227882 CDS NP_822850.1 29828216 1213193 complement(2048602..2050632) 1 NC_003155.4 catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue; x-prolyl-dipeptidyl aminopeptidase 2050632 1213193 SAV_1674 Streptomyces avermitilis MA-4680 x-prolyl-dipeptidyl aminopeptidase NP_822850.1 2048602 R 227882 CDS NP_822851.1 29828217 1213194 2050745..2052238 1 NC_003155.4 PF01433: Peptidase family M1; metallopeptidase 2052238 1213194 SAV_1675 Streptomyces avermitilis MA-4680 metallopeptidase NP_822851.1 2050745 D 227882 CDS NP_822852.1 29828218 1213195 complement(2052475..2052954) 1 NC_003155.4 hypothetical protein 2052954 1213195 SAV_1676 Streptomyces avermitilis MA-4680 hypothetical protein NP_822852.1 2052475 R 227882 CDS NP_822853.1 29828219 1213196 complement(2052998..2054461) 1 NC_003155.4 L-asparagine permease 2054461 ansP2 1213196 ansP2 Streptomyces avermitilis MA-4680 L-asparagine permease NP_822853.1 2052998 R 227882 CDS NP_822854.1 29828220 1213197 2054785..2055480 1 NC_003155.4 MerR family transcriptional regulator 2055480 1213197 SAV_1678 Streptomyces avermitilis MA-4680 MerR family transcriptional regulator NP_822854.1 2054785 D 227882 CDS NP_822855.1 29828221 1213198 complement(2055588..2056229) 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 2056229 1213198 SAV_1679 Streptomyces avermitilis MA-4680 dehydrogenase NP_822855.1 2055588 R 227882 CDS NP_822856.1 29828222 1210256 complement(2056428..2058635) 1 NC_003155.4 similar to glyoxysomal fatty acid beta-oxidation multifunctional protein MFP-a: including enoyl-CoA hydratase; 3-2-trans-enoyl-CoA isomerase; 3-hydroxybutyryl-CoA epimerase; 3-hydroxyacyl-CoA dehydrogenase; fatty acid oxidation complex alpha-subunit 2058635 fadB1 1210256 fadB1 Streptomyces avermitilis MA-4680 fatty acid oxidation complex alpha-subunit NP_822856.1 2056428 R 227882 CDS NP_822857.1 29828223 1210257 complement(2058688..2059902) 1 NC_003155.4 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 2059902 fadA4 1210257 fadA4 Streptomyces avermitilis MA-4680 acetyl-CoA acetyltransferase NP_822857.1 2058688 R 227882 CDS NP_822858.1 29828224 1213199 complement(2060054..2061247) 1 NC_003155.4 PF02515: CoA-transferase family III; fatty acid-CoA racemase 2061247 mcr 1213199 mcr Streptomyces avermitilis MA-4680 fatty acid-CoA racemase NP_822858.1 2060054 R 227882 CDS NP_822859.1 29828225 1213200 2061478..2062653 1 NC_003155.4 hypothetical protein 2062653 1213200 SAV_1683 Streptomyces avermitilis MA-4680 hypothetical protein NP_822859.1 2061478 D 227882 CDS NP_822860.1 29828226 1213201 complement(2062697..2063386) 1 NC_003155.4 endonuclease V 2063386 1213201 SAV_1684 Streptomyces avermitilis MA-4680 endonuclease V NP_822860.1 2062697 R 227882 CDS NP_822861.1 29828227 1213202 complement(2063421..2063747) 1 NC_003155.4 hypothetical protein 2063747 1213202 SAV_1685 Streptomyces avermitilis MA-4680 hypothetical protein NP_822861.1 2063421 R 227882 CDS NP_822862.1 29828228 1213203 complement(2063861..2064913) 1 NC_003155.4 PF02012: BNR/Asp-box repeat; oxidoreductase 2064913 1213203 SAV_1686 Streptomyces avermitilis MA-4680 oxidoreductase NP_822862.1 2063861 R 227882 CDS NP_822863.1 29828229 1213204 2065246..2065662 1 NC_003155.4 PF04686: Streptomyces sporulation and cell division protein, SsgA; cell division protein, regulatory protein 2065662 ssgA5 1213204 ssgA5 Streptomyces avermitilis MA-4680 cell division protein, regulatory protein NP_822863.1 2065246 D 227882 CDS NP_822864.1 29828230 1213205 complement(2065923..2066678) 1 NC_003155.4 hypothetical protein 2066678 1213205 SAV_1688 Streptomyces avermitilis MA-4680 hypothetical protein NP_822864.1 2065923 R 227882 CDS NP_822865.1 29828231 1213206 2066918..2068537 1 NC_003155.4 ABC transporter ATP-binding protein 2068537 1213206 SAV_1689 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_822865.1 2066918 D 227882 CDS NP_822866.1 29828232 1210258 2068821..2069597 1 NC_003155.4 dimethylarginine dimethylaminohydrolase 2069597 ddh 1210258 ddh Streptomyces avermitilis MA-4680 dimethylarginine dimethylaminohydrolase NP_822866.1 2068821 D 227882 CDS NP_822867.1 29828233 1213207 2069818..2070792 1 NC_003155.4 acyl-ACP desaturase 2070792 1213207 SAV_1691 Streptomyces avermitilis MA-4680 acyl-ACP desaturase NP_822867.1 2069818 D 227882 CDS NP_822868.1 29828234 1213208 complement(2070860..2071630) 1 NC_003155.4 hypothetical protein 2071630 1213208 SAV_1692 Streptomyces avermitilis MA-4680 hypothetical protein NP_822868.1 2070860 R 227882 CDS NP_822869.1 29828235 1213209 complement(2071759..2072004) 1 NC_003155.4 WhiB-family transcriptional regulator 2072004 whmD 1213209 whmD Streptomyces avermitilis MA-4680 WhiB-family transcriptional regulator NP_822869.1 2071759 R 227882 CDS NP_822870.1 29828236 1213210 2072296..2073087 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hydroxylase 2073087 1213210 SAV_1694 Streptomyces avermitilis MA-4680 hydroxylase NP_822870.1 2072296 D 227882 CDS NP_822871.1 29828237 1213211 complement(2073171..2074217) 1 NC_003155.4 LacI family transcriptional regulator 2074217 1213211 SAV_1695 Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_822871.1 2073171 R 227882 CDS NP_822872.1 29828238 1213212 complement(2074412..2075428) 1 NC_003155.4 hypothetical protein 2075428 1213212 SAV_1696 Streptomyces avermitilis MA-4680 hypothetical protein NP_822872.1 2074412 R 227882 CDS NP_822873.1 29828239 1210259 2075503..2076573 1 NC_003155.4 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; in mycobacteria LigC has weak intrinsic nick joining activities and is not essential for growth; ATP-dependent DNA ligase 2076573 ligC 1210259 ligC Streptomyces avermitilis MA-4680 ATP-dependent DNA ligase NP_822873.1 2075503 D 227882 CDS NP_822874.1 29828240 1213213 2076901..2077878 1 NC_003155.4 hypothetical protein 2077878 1213213 SAV_1698 Streptomyces avermitilis MA-4680 hypothetical protein NP_822874.1 2076901 D 227882 CDS NP_822875.1 29828241 1213214 complement(2077925..2078392) 1 NC_003155.4 MarR family transcriptional regulator 2078392 1213214 SAV_1699 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_822875.1 2077925 R 227882 CDS NP_822876.1 29828242 1210260 2078649..2079431 1 NC_003155.4 PF01144: Coenzyme A transferase; 3-oxoacid CoA-transferase subunit A 2079431 scoA 1210260 scoA Streptomyces avermitilis MA-4680 3-oxoacid CoA-transferase subunit A NP_822876.1 2078649 D 227882 CDS NP_822877.1 29828243 1210261 2079431..2080078 1 NC_003155.4 PF01144: Coenzyme A transferase; 3-oxoacid CoA-transferase subunit B 2080078 scoB 1210261 scoB Streptomyces avermitilis MA-4680 3-oxoacid CoA-transferase subunit B NP_822877.1 2079431 D 227882 CDS NP_822878.1 29828244 1210262 2080075..2080491 1 NC_003155.4 PF00108: Thiolase, N-terminal domain; beta-ketoadipyl-CoA thiolase 2080491 pcaF2 1210262 pcaF2 Streptomyces avermitilis MA-4680 beta-ketoadipyl-CoA thiolase NP_822878.1 2080075 D 227882 CDS NP_822879.1 29828245 1210263 2080504..2081274 1 NC_003155.4 PF00775: Dioxygenase; protocatechuate 3,4-dioxygenase beta subunit 2081274 pcaH 1210263 pcaH Streptomyces avermitilis MA-4680 protocatechuate 3,4-dioxygenase beta subunit NP_822879.1 2080504 D 227882 CDS NP_822880.1 29828246 1210264 2081220..2081840 1 NC_003155.4 PF00775: Dioxygenase; protocatechuate 3,4-dioxygenase alpha subunit 2081840 pcaG 1210264 pcaG Streptomyces avermitilis MA-4680 protocatechuate 3,4-dioxygenase alpha subunit NP_822880.1 2081220 D 227882 CDS NP_822881.1 29828247 1210265 2081837..2083174 1 NC_003155.4 PF00206: Lyase; 3-carboxy-cis,cis-muconate cycloisomerase 2083174 pcaB 1210265 pcaB Streptomyces avermitilis MA-4680 3-carboxy-cis,cis-muconate cycloisomerase NP_822881.1 2081837 D 227882 CDS NP_822882.1 29828248 1210266 2083171..2084310 1 NC_003155.4 PF02627: Carboxymuconolactone decarboxylase family; 3-oxoadipate enol-lactone hydrolase 2084310 pcaL1 1210266 pcaL1 Streptomyces avermitilis MA-4680 3-oxoadipate enol-lactone hydrolase NP_822882.1 2083171 D 227882 CDS NP_822883.1 29828249 1213215 complement(2084414..2087101) 1 NC_003155.4 regulatory protein 2087101 1213215 SAV_1707 Streptomyces avermitilis MA-4680 regulatory protein NP_822883.1 2084414 R 227882 CDS NP_822884.1 29828250 1213216 2087282..2088634 1 NC_003155.4 PF00083: Sugar (and other) transporter; integral membrane transport protein 2088634 1213216 SAV_1708 Streptomyces avermitilis MA-4680 integral membrane transport protein NP_822884.1 2087282 D 227882 CDS NP_822885.1 29828251 1213217 2088639..2089793 1 NC_003155.4 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 2089793 anmK 1213217 anmK Streptomyces avermitilis MA-4680 anhydro-N-acetylmuramic acid kinase NP_822885.1 2088639 D 227882 CDS NP_822886.1 29828252 1213218 2089889..2090881 1 NC_003155.4 hypothetical protein 2090881 1213218 SAV_1710 Streptomyces avermitilis MA-4680 hypothetical protein NP_822886.1 2089889 D 227882 CDS NP_822887.1 29828253 1213219 complement(2091029..2091643) 1 NC_003155.4 TetR family transcriptional regulator 2091643 1213219 SAV_1711 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_822887.1 2091029 R 227882 CDS NP_822888.1 29828254 1213220 2091875..2092885 1 NC_003155.4 hypothetical protein 2092885 1213220 SAV_1712 Streptomyces avermitilis MA-4680 hypothetical protein NP_822888.1 2091875 D 227882 CDS NP_822889.1 29828255 1213221 2092882..2093826 1 NC_003155.4 integral membrane protein 2093826 1213221 SAV_1713 Streptomyces avermitilis MA-4680 integral membrane protein NP_822889.1 2092882 D 227882 CDS NP_822890.1 29828256 1213222 complement(2093917..2094774) 1 NC_003155.4 PF03803: Scramblase; hypothetical protein 2094774 1213222 SAV_1714 Streptomyces avermitilis MA-4680 hypothetical protein NP_822890.1 2093917 R 227882 CDS NP_822891.1 29828257 1210267 complement(2094827..2096878) 1 NC_003155.4 PF04185: Phosphoesterase family; non-hemolytic phospholipase C 2096878 plcA 1210267 plcA Streptomyces avermitilis MA-4680 non-hemolytic phospholipase C NP_822891.1 2094827 R 227882 CDS NP_822892.1 29828258 1213223 complement(2097186..2097869) 1 NC_003155.4 LysR family transcriptional regulator 2097869 1213223 SAV_1716 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_822892.1 2097186 R 227882 CDS NP_822893.1 29828259 1213224 complement(2097860..2098342) 1 NC_003155.4 hypothetical protein 2098342 1213224 SAV_1717 Streptomyces avermitilis MA-4680 hypothetical protein NP_822893.1 2097860 R 227882 CDS NP_822894.1 29828260 1213225 2098481..2098867 1 NC_003155.4 substrate-binding protein 2098867 1213225 SAV_1718 Streptomyces avermitilis MA-4680 substrate-binding protein NP_822894.1 2098481 D 227882 CDS NP_822895.1 29828261 1213226 2098919..2099743 1 NC_003155.4 ABC transporter substrate-binding protein 2099743 1213226 SAV_1719 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_822895.1 2098919 D 227882 CDS NP_822896.1 29828262 1213227 2099740..2100609 1 NC_003155.4 ABC transporter permease 2100609 1213227 SAV_1720 Streptomyces avermitilis MA-4680 ABC transporter permease NP_822896.1 2099740 D 227882 CDS NP_822897.1 29828263 1213228 2100606..2101700 1 NC_003155.4 ABC transporter ATP-binding protein 2101700 1213228 SAV_1721 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_822897.1 2100606 D 227882 CDS NP_822898.1 29828264 1213229 2101766..2102668 1 NC_003155.4 PF03473: MOSC domain; hypothetical protein 2102668 1213229 SAV_1722 Streptomyces avermitilis MA-4680 hypothetical protein NP_822898.1 2101766 D 227882 CDS NP_822899.1 29828265 1213230 complement(2102982..2105156) 1 NC_003155.4 mycodextranase 2105156 1213230 SAV_1723 Streptomyces avermitilis MA-4680 mycodextranase NP_822899.1 2102982 R 227882 CDS NP_822900.1 29828266 1210268 complement(2105214..2106815) 1 NC_003155.4 alpha-glucosidase 2106815 aglA1 1210268 aglA1 Streptomyces avermitilis MA-4680 alpha-glucosidase NP_822900.1 2105214 R 227882 CDS NP_822901.1 29828267 1213231 complement(2106847..2107722) 1 NC_003155.4 ABC transporter permease 2107722 1213231 SAV_1725 Streptomyces avermitilis MA-4680 ABC transporter permease NP_822901.1 2106847 R 227882 CDS NP_822902.1 29828268 1213232 complement(2107719..2108675) 1 NC_003155.4 ABC transporter permease 2108675 1213232 SAV_1726 Streptomyces avermitilis MA-4680 ABC transporter permease NP_822902.1 2107719 R 227882 CDS NP_822903.1 29828269 1213233 complement(2108681..2110021) 1 NC_003155.4 sugar uptake sugar ABC transporter substrate-binding protein 2110021 1213233 SAV_1727 Streptomyces avermitilis MA-4680 sugar uptake sugar ABC transporter substrate-binding protein NP_822903.1 2108681 R 227882 CDS NP_822904.1 29828270 1213234 complement(2110168..2111160) 1 NC_003155.4 LacI family transcriptional regulator 2111160 1213234 SAV_1728 Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_822904.1 2110168 R 227882 CDS NP_822905.1 29828271 1213235 complement(2111207..2111935) 1 NC_003155.4 GntR family transcriptional regulator 2111935 1213235 SAV_1729 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_822905.1 2111207 R 227882 CDS NP_822906.1 29828272 1213236 complement(2111948..2112949) 1 NC_003155.4 proline racemase 2112949 1213236 SAV_1730 Streptomyces avermitilis MA-4680 proline racemase NP_822906.1 2111948 R 227882 CDS NP_822907.1 29828273 1210269 complement(2112964..2113854) 1 NC_003155.4 dihydrodipicolinate synthase 2113854 dapA1 1210269 dapA1 Streptomyces avermitilis MA-4680 dihydrodipicolinate synthase NP_822907.1 2112964 R 227882 CDS NP_822908.1 29828274 1213237 complement(2113851..2115350) 1 NC_003155.4 oxidase 2115350 1213237 SAV_1732 Streptomyces avermitilis MA-4680 oxidase NP_822908.1 2113851 R 227882 CDS NP_822909.1 29828275 1213238 complement(2115340..2115639) 1 NC_003155.4 hypothetical protein 2115639 1213238 SAV_1733 Streptomyces avermitilis MA-4680 hypothetical protein NP_822909.1 2115340 R 227882 CDS NP_822910.1 29828276 1213239 complement(2115636..2116883) 1 NC_003155.4 PF01266: FAD dependent oxidoreductase; oxidoreductase 2116883 1213239 SAV_1734 Streptomyces avermitilis MA-4680 oxidoreductase NP_822910.1 2115636 R 227882 CDS NP_822911.1 29828277 1213240 complement(2116980..2117837) 1 NC_003155.4 ABC transporter permease 2117837 1213240 SAV_1735 Streptomyces avermitilis MA-4680 ABC transporter permease NP_822911.1 2116980 R 227882 CDS NP_822912.1 29828278 1213241 complement(2117818..2118711) 1 NC_003155.4 ABC transporter permease 2118711 1213241 SAV_1736 Streptomyces avermitilis MA-4680 ABC transporter permease NP_822912.1 2117818 R 227882 CDS NP_822913.1 29828279 1213242 complement(2118719..2119963) 1 NC_003155.4 ABC transporter 2119963 1213242 SAV_1737 Streptomyces avermitilis MA-4680 ABC transporter NP_822913.1 2118719 R 227882 CDS NP_822914.1 29828280 1213243 complement(2119989..2121026) 1 NC_003155.4 ABC transporter ATP-binding protein 2121026 1213243 SAV_1738 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_822914.1 2119989 R 227882 CDS NP_822915.1 29828281 1213244 2121131..2121886 1 NC_003155.4 GntR family transcriptional regulator 2121886 1213244 SAV_1739 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_822915.1 2121131 D 227882 CDS NP_822916.1 29828282 1213245 2121925..2122722 1 NC_003155.4 PF02743: Cache domain; hypothetical protein 2122722 1213245 SAV_1740 Streptomyces avermitilis MA-4680 hypothetical protein NP_822916.1 2121925 D 227882 CDS NP_822917.1 29828283 1213246 complement(2122777..2123445) 1 NC_003155.4 PF00989: PAS domain; hypothetical protein 2123445 1213246 SAV_1741 Streptomyces avermitilis MA-4680 hypothetical protein NP_822917.1 2122777 R 227882 CDS NP_822918.1 29828284 1213247 2123698..2124354 1 NC_003155.4 transcriptional regulator 2124354 1213247 SAV_1742 Streptomyces avermitilis MA-4680 transcriptional regulator NP_822918.1 2123698 D 227882 CDS NP_822919.1 29828285 1213248 2124387..2124917 1 NC_003155.4 hypothetical protein 2124917 1213248 SAV_1743 Streptomyces avermitilis MA-4680 hypothetical protein NP_822919.1 2124387 D 227882 CDS NP_822920.1 29828286 1213249 2124930..2126135 1 NC_003155.4 integral membrane protein 2126135 1213249 SAV_1744 Streptomyces avermitilis MA-4680 integral membrane protein NP_822920.1 2124930 D 227882 CDS NP_822921.1 29828287 1213250 2126119..2127579 1 NC_003155.4 PF01360: Monooxygenase; monooxygenase 2127579 1213250 SAV_1745 Streptomyces avermitilis MA-4680 monooxygenase NP_822921.1 2126119 D 227882 CDS NP_822922.1 29828288 1213251 complement(2127643..2128686) 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 2128686 1213251 SAV_1746 Streptomyces avermitilis MA-4680 hydrolase NP_822922.1 2127643 R 227882 CDS NP_822923.1 29828289 1213252 2128854..2129156 1 NC_003155.4 hypothetical protein 2129156 1213252 SAV_1747 Streptomyces avermitilis MA-4680 hypothetical protein NP_822923.1 2128854 D 227882 CDS NP_822924.1 29828290 1210270 complement(2129199..2129888) 1 NC_003155.4 PF01648: 4'-phosphopantetheinyl transferase superfamily; phosphopantetheinyl transferase 2129888 pptA2 1210270 pptA2 Streptomyces avermitilis MA-4680 phosphopantetheinyl transferase NP_822924.1 2129199 R 227882 CDS NP_822925.1 29828291 1213253 complement(2129885..2130757) 1 NC_003155.4 SimX4-like protein 2130757 1213253 SAV_1749 Streptomyces avermitilis MA-4680 SimX4-like protein NP_822925.1 2129885 R 227882 CDS NP_822926.1 29828292 1213254 2131075..2132220 1 NC_003155.4 PF02222: ATP-grasp domain; hypothetical protein 2132220 1213254 SAV_1750 Streptomyces avermitilis MA-4680 hypothetical protein NP_822926.1 2131075 D 227882 CDS NP_822927.1 29828293 1210271 2132343..2134028 1 NC_003155.4 chitinase A 2134028 chiA2 1210271 chiA2 Streptomyces avermitilis MA-4680 chitinase A NP_822927.1 2132343 D 227882 CDS NP_822928.1 29828294 1213255 complement(2134074..2135324) 1 NC_003155.4 PF01120: Alpha-L-fucosidase; glycosyl hydrolase 2135324 1213255 SAV_1752 Streptomyces avermitilis MA-4680 glycosyl hydrolase NP_822928.1 2134074 R 227882 CDS NP_822929.1 29828295 1210272 complement(2135431..2138499) 1 NC_003155.4 alpha-mannosidase 2138499 ama1 1210272 ama1 Streptomyces avermitilis MA-4680 alpha-mannosidase NP_822929.1 2135431 R 227882 CDS NP_822930.1 29828296 1210273 complement(2138564..2139901) 1 NC_003155.4 6-phospho-beta-glucosidase 2139901 bglA1 1210273 bglA1 Streptomyces avermitilis MA-4680 6-phospho-beta-glucosidase NP_822930.1 2138564 R 227882 CDS NP_822931.1 29828297 1213256 complement(2139898..2140683) 1 NC_003155.4 DeoR family transcriptional regulator 2140683 1213256 SAV_1755 Streptomyces avermitilis MA-4680 DeoR family transcriptional regulator NP_822931.1 2139898 R 227882 CDS NP_822932.1 29828298 1213257 2140789..2141826 1 NC_003155.4 carbohydrate kinase 2141826 1213257 SAV_1756 Streptomyces avermitilis MA-4680 carbohydrate kinase NP_822932.1 2140789 D 227882 CDS NP_822933.1 29828299 1213258 2141900..2143195 1 NC_003155.4 sugar ABC transporter substrate-binding protein 2143195 1213258 SAV_1757 Streptomyces avermitilis MA-4680 sugar ABC transporter substrate-binding protein NP_822933.1 2141900 D 227882 CDS NP_822934.1 29828300 1213259 2143197..2144159 1 NC_003155.4 sugar ABC transporter permease 2144159 1213259 SAV_1758 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_822934.1 2143197 D 227882 CDS NP_822935.1 29828301 1213260 2144172..2145008 1 NC_003155.4 sugar ABC transporter permease 2145008 1213260 SAV_1759 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_822935.1 2144172 D 227882 CDS NP_822936.1 29828302 1210274 2145008..2147932 1 NC_003155.4 beta-galactosidase 2147932 bga4 1210274 bga4 Streptomyces avermitilis MA-4680 beta-galactosidase NP_822936.1 2145008 D 227882 CDS NP_822937.1 29828303 1213261 2148133..2149821 1 NC_003155.4 PF02231: PHP domain N-terminal region; hypothetical protein 2149821 1213261 SAV_1761 Streptomyces avermitilis MA-4680 hypothetical protein NP_822937.1 2148133 D 227882 CDS NP_822938.1 29828304 1213262 complement(2150017..2152782) 1 NC_003155.4 similar to StaR of Streptomyces toyocaensis NRRL15009; hypothetical protein 2152782 1213262 SAV_1762 Streptomyces avermitilis MA-4680 hypothetical protein NP_822938.1 2150017 R 227882 CDS NP_822939.1 29828305 1213263 2153091..2154362 1 NC_003155.4 PF03734: ErfK/YbiS/YcfS/YnhG; lipoprotein 2154362 1213263 SAV_1763 Streptomyces avermitilis MA-4680 lipoprotein NP_822939.1 2153091 D 227882 CDS NP_822940.1 29828306 1210275 2155064..2156464 1 NC_003155.4 endo-1,3-beta-glucanase 2156464 lamA1 1210275 lamA1 Streptomyces avermitilis MA-4680 endo-1,3-beta-glucanase NP_822940.1 2155064 D 227882 CDS NP_822941.1 29828307 1213264 complement(2156557..2157453) 1 NC_003155.4 AraC family transcription regulator 2157453 1213264 SAV_1765 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_822941.1 2156557 R 227882 CDS NP_822942.1 29828308 1210276 2157594..2159675 1 NC_003155.4 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 2159675 tkt1 1210276 tkt1 Streptomyces avermitilis MA-4680 transketolase NP_822942.1 2157594 D 227882 CDS NP_822943.1 29828309 1210277 2159695..2160831 1 NC_003155.4 catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate; transaldolase 2160831 tal1 1210277 tal1 Streptomyces avermitilis MA-4680 transaldolase NP_822943.1 2159695 D 227882 CDS NP_822944.1 29828310 1210278 2160828..2162474 1 NC_003155.4 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 2162474 zwf1 1210278 zwf1 Streptomyces avermitilis MA-4680 glucose-6-phosphate 1-dehydrogenase NP_822944.1 2160828 D 227882 CDS NP_822945.1 29828311 1213265 2162471..2163406 1 NC_003155.4 oxppcycle protein 2163406 opcA1 1213265 opcA1 Streptomyces avermitilis MA-4680 oxppcycle protein NP_822945.1 2162471 D 227882 CDS NP_822946.1 29828312 1210279 2163399..2165048 1 NC_003155.4 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 2165048 pgi 1210279 pgi Streptomyces avermitilis MA-4680 glucose-6-phosphate isomerase NP_822946.1 2163399 D 227882 CDS NP_822947.1 29828313 1210280 2165064..2165942 1 NC_003155.4 similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate; 6-phosphogluconate dehydrogenase 2165942 gnd1 1210280 gnd1 Streptomyces avermitilis MA-4680 6-phosphogluconate dehydrogenase NP_822947.1 2165064 D 227882 CDS NP_822948.1 29828314 1213266 2165949..2166560 1 NC_003155.4 mutase 2166560 1213266 SAV_1772 Streptomyces avermitilis MA-4680 mutase NP_822948.1 2165949 D 227882 CDS NP_822949.1 29828315 1213267 2166642..2167097 1 NC_003155.4 PF05099: Tellurite resistance protein TerB; tellurium resistance protein 2167097 terB 1213267 terB Streptomyces avermitilis MA-4680 tellurium resistance protein NP_822949.1 2166642 D 227882 CDS NP_822950.1 29828316 1213268 2167468..2170362 1 NC_003155.4 PF03098: animal haem peroxidase; peroxidase 2170362 1213268 SAV_1774 Streptomyces avermitilis MA-4680 peroxidase NP_822950.1 2167468 D 227882 CDS NP_822951.1 29828317 1213269 2170472..2171929 1 NC_003155.4 hypothetical protein 2171929 1213269 SAV_1775 Streptomyces avermitilis MA-4680 hypothetical protein NP_822951.1 2170472 D 227882 CDS NP_822952.1 29828318 1210281 complement(2171936..2173741) 1 NC_003155.4 sugar phosphate isomerase/epimerase 2173741 1210281 SAV_1776 Streptomyces avermitilis MA-4680 sugar phosphate isomerase/epimerase NP_822952.1 2171936 R 227882 CDS NP_822953.1 29828319 1210282 complement(2173767..2174642) 1 NC_003155.4 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 2174642 aroE 1210282 aroE Streptomyces avermitilis MA-4680 shikimate 5-dehydrogenase NP_822953.1 2173767 R 227882 CDS NP_822954.1 29828320 1213270 2174818..2175483 1 NC_003155.4 TetR family transcriptional regulator 2175483 1213270 SAV_1778 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_822954.1 2174818 D 227882 CDS NP_822955.1 29828321 1213271 2175736..2177088 1 NC_003155.4 PF00083: Sugar (and other) transporter; 3-(2-hydroxyphenyl) propionic acid transporter 2177088 1213271 SAV_1779 Streptomyces avermitilis MA-4680 3-(2-hydroxyphenyl) propionic acid transporter NP_822955.1 2175736 D 227882 CDS NP_822956.1 29828322 1213272 complement(2177265..2177702) 1 NC_003155.4 PF01243: Pyridoxamine 5'-phosphate oxidase; hypothetical protein 2177702 1213272 SAV_1780 Streptomyces avermitilis MA-4680 hypothetical protein NP_822956.1 2177265 R 227882 CDS NP_822957.1 29828323 1213273 2177771..2178355 1 NC_003155.4 TetR family transcriptional regulator 2178355 1213273 SAV_1781 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_822957.1 2177771 D 227882 CDS NP_822958.1 29828324 1213274 2178352..2179725 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 2179725 1213274 SAV_1782 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_822958.1 2178352 D 227882 CDS NP_822959.1 29828325 1213275 2179785..2181011 1 NC_003155.4 PF00144: Beta-lactamase; hypothetical protein 2181011 1213275 SAV_1783 Streptomyces avermitilis MA-4680 hypothetical protein NP_822959.1 2179785 D 227882 CDS NP_822960.1 29828326 1213276 complement(2181020..2181445) 1 NC_003155.4 PF07366: Protein of unknown function (DUF1486); hypothetical protein 2181445 1213276 SAV_1784 Streptomyces avermitilis MA-4680 hypothetical protein NP_822960.1 2181020 R 227882 CDS NP_822961.1 29828327 1213277 complement(2181486..2182337) 1 NC_003155.4 hypothetical protein 2182337 1213277 SAV_1785 Streptomyces avermitilis MA-4680 hypothetical protein NP_822961.1 2181486 R 227882 CDS NP_822962.1 29828328 1213278 complement(2182334..2183068) 1 NC_003155.4 MerR family transcriptional regulator 2183068 1213278 SAV_1786 Streptomyces avermitilis MA-4680 MerR family transcriptional regulator NP_822962.1 2182334 R 227882 CDS NP_822963.1 29828329 1213279 complement(2183193..2184347) 1 NC_003155.4 PF03435: Saccharopine dehydrogenase; saccharopine dehydrogenase 2184347 1213279 SAV_1787 Streptomyces avermitilis MA-4680 saccharopine dehydrogenase NP_822963.1 2183193 R 227882 CDS NP_822964.1 29828330 1213280 complement(2184340..2185449) 1 NC_003155.4 PF05222: Alanine dehydrogenase/PNT, N-terminal domain; saccharopine dehydrogenase 2185449 1213280 SAV_1788 Streptomyces avermitilis MA-4680 saccharopine dehydrogenase NP_822964.1 2184340 R 227882 CDS NP_822965.1 29828331 1213281 complement(2185446..2186591) 1 NC_003155.4 sarcosine oxidase subunit beta 2186591 1213281 SAV_1789 Streptomyces avermitilis MA-4680 sarcosine oxidase subunit beta NP_822965.1 2185446 R 227882 CDS NP_822966.1 29828332 1210283 complement(2186588..2187568) 1 NC_003155.4 ornithine cyclodeaminase 2187568 arcB1 1210283 arcB1 Streptomyces avermitilis MA-4680 ornithine cyclodeaminase NP_822966.1 2186588 R 227882 CDS NP_822967.1 29828333 1210284 complement(2187813..2188505) 1 NC_003155.4 GTP cyclohydrolase II 2188505 ribA2 1210284 ribA2 Streptomyces avermitilis MA-4680 GTP cyclohydrolase II NP_822967.1 2187813 R 227882 CDS NP_822968.1 29828334 1213282 2188543..2189343 1 NC_003155.4 PF02633: Creatinine amidohydrolase; hypothetical protein 2189343 1213282 SAV_1792 Streptomyces avermitilis MA-4680 hypothetical protein NP_822968.1 2188543 D 227882 CDS NP_822969.1 29828335 1213283 complement(2189175..2190674) 1 NC_003155.4 PF03706: Uncharacterised protein family (UPF0104); hypothetical protein 2190674 1213283 SAV_1793 Streptomyces avermitilis MA-4680 hypothetical protein NP_822969.1 2189175 R 227882 CDS NP_822970.1 29828336 1213284 complement(2190671..2191627) 1 NC_003155.4 hypothetical protein 2191627 1213284 SAV_1794 Streptomyces avermitilis MA-4680 hypothetical protein NP_822970.1 2190671 R 227882 CDS NP_822971.1 29828337 1213285 complement(2191624..2192766) 1 NC_003155.4 PF00534: Glycosyl transferases group 1; glycosyl transferase 2192766 1213285 SAV_1795 Streptomyces avermitilis MA-4680 glycosyl transferase NP_822971.1 2191624 R 227882 CDS NP_822972.1 29828338 1213286 complement(2192859..2193257) 1 NC_003155.4 PF01242: 6-pyruvoyl tetrahydropterin synthase; hypothetical protein 2193257 1213286 SAV_1796 Streptomyces avermitilis MA-4680 hypothetical protein NP_822972.1 2192859 R 227882 CDS NP_822973.1 29828339 1213287 complement(2193432..2194412) 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 2194412 1213287 SAV_1797 Streptomyces avermitilis MA-4680 dehydrogenase NP_822973.1 2193432 R 227882 CDS NP_822974.1 29828340 1213288 2194521..2195243 1 NC_003155.4 PF01066: CDP-alcohol phosphatidyltransferase; hypothetical protein 2195243 1213288 SAV_1798 Streptomyces avermitilis MA-4680 hypothetical protein NP_822974.1 2194521 D 227882 CDS NP_822975.1 29828341 1213289 complement(2195380..2197470) 1 NC_003155.4 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 2197470 fusA3 1213289 fusA3 Streptomyces avermitilis MA-4680 elongation factor G NP_822975.1 2195380 R 227882 CDS NP_822976.1 29828342 1213290 complement(2197922..2199811) 1 NC_003155.4 PF00754: F5/8 type C domain; protein 2199811 1213290 SAV_1800 Streptomyces avermitilis MA-4680 protein NP_822976.1 2197922 R 227882 CDS NP_822977.1 29828343 1210285 complement(2200016..2201374) 1 NC_003155.4 beta-glucosidase 2201374 bglC1 1210285 bglC1 Streptomyces avermitilis MA-4680 beta-glucosidase NP_822977.1 2200016 R 227882 CDS NP_822978.1 29828344 1213291 complement(2201404..2202276) 1 NC_003155.4 sugar ABC transporter permease 2202276 1213291 SAV_1802 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_822978.1 2201404 R 227882 CDS NP_822979.1 29828345 1213292 complement(2202269..2203267) 1 NC_003155.4 sugar ABC transporter permease 2203267 1213292 SAV_1803 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_822979.1 2202269 R 227882 CDS NP_822980.1 29828346 1213293 complement(2203282..2204598) 1 NC_003155.4 sugar ABC transporter substrate-binding protein 2204598 1213293 SAV_1804 Streptomyces avermitilis MA-4680 sugar ABC transporter substrate-binding protein NP_822980.1 2203282 R 227882 CDS NP_822981.1 29828347 1213294 2204780..2206078 1 NC_003155.4 transcriptional regulator 2206078 1213294 SAV_1805 Streptomyces avermitilis MA-4680 transcriptional regulator NP_822981.1 2204780 D 227882 CDS NP_822982.1 29828348 1213295 2206416..2208215 1 NC_003155.4 protein 2208215 1213295 SAV_1806 Streptomyces avermitilis MA-4680 protein NP_822982.1 2206416 D 227882 CDS NP_822983.1 29828349 1213296 complement(2208269..2209414) 1 NC_003155.4 PF00877: NlpC/P60 family; hypothetical protein 2209414 1213296 SAV_1807 Streptomyces avermitilis MA-4680 hypothetical protein NP_822983.1 2208269 R 227882 CDS NP_822984.1 29828350 1210286 complement(2209514..2210155) 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 2210155 sig18 1210286 sig18 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_822984.1 2209514 R 227882 CDS NP_822985.1 29828351 1213297 complement(2210275..2210961) 1 NC_003155.4 PF01427: D-ala-D-ala dipeptidase; dipeptidase 2210961 1213297 SAV_1809 Streptomyces avermitilis MA-4680 dipeptidase NP_822985.1 2210275 R 227882 CDS NP_822986.1 29828352 1213298 complement(2211087..2212124) 1 NC_003155.4 frameshift; regulatory protein 2212124 1213298 SAV_1810 Streptomyces avermitilis MA-4680 regulatory protein NP_822986.1 2211087 R 227882 CDS NP_822987.1 29828353 1213299 complement(2212064..2214322) 1 NC_003155.4 frameshift; regulatory protein 2214322 1213299 SAV_1811 Streptomyces avermitilis MA-4680 regulatory protein NP_822987.1 2212064 R 227882 CDS NP_822988.1 29828354 1213300 2214722..2215747 1 NC_003155.4 hypothetical protein 2215747 1213300 SAV_1812 Streptomyces avermitilis MA-4680 hypothetical protein NP_822988.1 2214722 D 227882 CDS NP_822989.1 29828355 1213301 2215992..2216453 1 NC_003155.4 hypothetical protein 2216453 1213301 SAV_1813 Streptomyces avermitilis MA-4680 hypothetical protein NP_822989.1 2215992 D 227882 CDS NP_822990.1 29828356 1213302 complement(2217271..2219466) 1 NC_003155.4 ATP/GTP-binding protein 2219466 1213302 SAV_1814 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_822990.1 2217271 R 227882 CDS NP_822991.1 29828357 1213303 complement(2220285..2222168) 1 NC_003155.4 ATP/GTP-binding protein 2222168 1213303 SAV_1815 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_822991.1 2220285 R 227882 CDS NP_822992.1 29828358 1213304 complement(2223614..2225155) 1 NC_003155.4 PF00171: Aldehyde dehydrogenase family; aldehyde dehydrogenase 2225155 1213304 SAV_1816 Streptomyces avermitilis MA-4680 aldehyde dehydrogenase NP_822992.1 2223614 R 227882 CDS NP_822993.1 29828359 1210288 complement(2225284..2226183) 1 NC_003155.4 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 2226183 sucD1 1210288 sucD1 Streptomyces avermitilis MA-4680 succinyl-CoA synthetase subunit alpha NP_822993.1 2225284 R 227882 CDS NP_822994.1 29828360 1210289 complement(2226195..2227325) 1 NC_003155.4 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 2227325 sucC 1210289 sucC Streptomyces avermitilis MA-4680 succinyl-CoA synthetase subunit beta NP_822994.1 2226195 R 227882 CDS NP_822995.1 29828361 1210290 2227504..2229198 1 NC_003155.4 TPP-requiring enzyme (acetolactate synthase II) 2229198 ilvB3 1210290 ilvB3 Streptomyces avermitilis MA-4680 TPP-requiring enzyme (acetolactate synthase II) NP_822995.1 2227504 D 227882 CDS NP_822996.1 29828362 1213305 2229211..2230440 1 NC_003155.4 catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase 2230440 1213305 SAV_1820 Streptomyces avermitilis MA-4680 formyl-coenzyme A transferase NP_822996.1 2229211 D 227882 CDS NP_822997.1 29828363 1213306 2230442..2232589 1 NC_003155.4 acyl-CoA synthetase (NDP forming type) 2232589 acdA1 1213306 acdA1 Streptomyces avermitilis MA-4680 acyl-CoA synthetase (NDP forming type) NP_822997.1 2230442 D 227882 CDS NP_822998.1 29828364 1213307 2232616..2234097 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane transport protein 2234097 1213307 SAV_1822 Streptomyces avermitilis MA-4680 transmembrane transport protein NP_822998.1 2232616 D 227882 CDS NP_822999.1 29828365 1213308 2234099..2235505 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane transport protein 2235505 1213308 SAV_1823 Streptomyces avermitilis MA-4680 transmembrane transport protein NP_822999.1 2234099 D 227882 CDS NP_823000.1 29828366 1213309 complement(2235737..2236741) 1 NC_003155.4 DNA-binding protein 2236741 1213309 SAV_1824 Streptomyces avermitilis MA-4680 DNA-binding protein NP_823000.1 2235737 R 227882 CDS NP_823001.1 29828367 1213310 complement(2236754..2237962) 1 NC_003155.4 PF01408: Oxidoreductase family, NAD-binding Rossmann fold; oxidoreductase 2237962 1213310 SAV_1825 Streptomyces avermitilis MA-4680 oxidoreductase NP_823001.1 2236754 R 227882 CDS NP_823002.1 29828368 1213311 complement(2238014..2239063) 1 NC_003155.4 PF00532: Periplasmic binding proteins and sugar binding domain of the LacI family; solute binding protein 2239063 1213311 SAV_1826 Streptomyces avermitilis MA-4680 solute binding protein NP_823002.1 2238014 R 227882 CDS NP_823003.1 29828369 1213312 complement(2239081..2240100) 1 NC_003155.4 ABC transporter permease 2240100 1213312 SAV_1827 Streptomyces avermitilis MA-4680 ABC transporter permease NP_823003.1 2239081 R 227882 CDS NP_823004.1 29828370 1213313 complement(2240097..2241635) 1 NC_003155.4 ABC transporter ATP-binding protein 2241635 1213313 SAV_1828 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_823004.1 2240097 R 227882 CDS NP_823005.1 29828371 1213314 complement(2241772..2242962) 1 NC_003155.4 transcriptional regulator 2242962 1213314 SAV_1829 Streptomyces avermitilis MA-4680 transcriptional regulator NP_823005.1 2241772 R 227882 CDS NP_823006.1 29828372 1213315 complement(2243335..2244009) 1 NC_003155.4 GntR family transcriptional regulator 2244009 1213315 SAV_1830 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_823006.1 2243335 R 227882 CDS NP_823007.1 29828373 1210291 complement(2244160..2245107) 1 NC_003155.4 FabH; beta-ketoacyl-ACP synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-ACP synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase III 2245107 fabH2 1210291 fabH2 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP synthase III NP_823007.1 2244160 R 227882 CDS NP_823008.1 29828374 1213316 complement(2245408..2246739) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; integral membrane transporter 2246739 1213316 SAV_1832 Streptomyces avermitilis MA-4680 integral membrane transporter NP_823008.1 2245408 R 227882 CDS NP_823009.1 29828375 1213317 2247042..2248013 1 NC_003155.4 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 2248013 1213317 SAV_1833 Streptomyces avermitilis MA-4680 2-dehydropantoate 2-reductase NP_823009.1 2247042 D 227882 CDS NP_823010.1 29828376 1213318 2248010..2249935 1 NC_003155.4 PF00384: Molybdopterin oxidoreductase; formate dehydrogenase, major subunit (formate dehydrogenase alpha subunit) 2249935 fdnG 1213318 fdnG Streptomyces avermitilis MA-4680 formate dehydrogenase, major subunit (formate dehydrogenase alpha subunit) NP_823010.1 2248010 D 227882 CDS NP_823011.1 29828377 1210292 2249944..2251767 1 NC_003155.4 NADH dehydrogenase I chain F 2251767 nuoF2 1210292 nuoF2 Streptomyces avermitilis MA-4680 NADH dehydrogenase I chain F NP_823011.1 2249944 D 227882 CDS NP_823012.1 29828378 1210293 2251764..2252624 1 NC_003155.4 NADH dehydrogenase I chain G 2252624 nuoG2 1210293 nuoG2 Streptomyces avermitilis MA-4680 NADH dehydrogenase I chain G NP_823012.1 2251764 D 227882 CDS NP_823013.1 29828379 1210294 2252632..2253480 1 NC_003155.4 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 2253480 fdhD 1210294 fdhD Streptomyces avermitilis MA-4680 formate dehydrogenase accessory protein NP_823013.1 2252632 D 227882 CDS NP_823014.1 29828380 1213319 complement(2253602..2254159) 1 NC_003155.4 2,3-dihydroxy-2,3-dihydrobenzoate synthase, PF00857: Isochorismatase family; isochorismatase 2254159 dhbB 1213319 dhbB Streptomyces avermitilis MA-4680 isochorismatase NP_823014.1 2253602 R 227882 CDS NP_823015.1 29828381 1213320 complement(2254179..2254613) 1 NC_003155.4 MarR family transcriptional regulator 2254613 1213320 SAV_1839 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_823015.1 2254179 R 227882 CDS NP_823016.1 29828382 1213321 2254913..2255629 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 2255629 1213321 SAV_1840 Streptomyces avermitilis MA-4680 dehydrogenase NP_823016.1 2254913 D 227882 CDS NP_823017.1 29828383 1213322 2255652..2256032 1 NC_003155.4 hypothetical protein 2256032 1213322 SAV_1841 Streptomyces avermitilis MA-4680 hypothetical protein NP_823017.1 2255652 D 227882 CDS NP_823018.1 29828384 1210295 2256926..2258803 1 NC_003155.4 neuraminidase 2258803 nanH 1210295 nanH Streptomyces avermitilis MA-4680 neuraminidase NP_823018.1 2256926 D 227882 CDS NP_823019.1 29828385 1213323 2258814..2260046 1 NC_003155.4 hypothetical protein 2260046 1213323 SAV_1843 Streptomyces avermitilis MA-4680 hypothetical protein NP_823019.1 2258814 D 227882 CDS NP_823020.1 29828386 1213324 complement(2259985..2261025) 1 NC_003155.4 PF01758: Sodium Bile acid symporter family; hypothetical protein 2261025 1213324 SAV_1844 Streptomyces avermitilis MA-4680 hypothetical protein NP_823020.1 2259985 R 227882 CDS NP_823021.1 29828387 1213325 2261159..2262028 1 NC_003155.4 LysR family transcriptional regulator 2262028 1213325 SAV_1845 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_823021.1 2261159 D 227882 CDS NP_823022.1 29828388 1213326 complement(2262049..2263026) 1 NC_003155.4 transcription regulator AsnC 2263026 1213326 SAV_1846 Streptomyces avermitilis MA-4680 transcription regulator AsnC NP_823022.1 2262049 R 227882 CDS NP_823023.1 29828389 1213327 2263141..2264625 1 NC_003155.4 PF07690: Major Facilitator Superfamily; integral membrane efflux protein 2264625 1213327 SAV_1847 Streptomyces avermitilis MA-4680 integral membrane efflux protein NP_823023.1 2263141 D 227882 CDS NP_823024.1 29828390 1210296 2264965..2266791 1 NC_003155.4 PF00501: AMP-binding enzyme; acyl-CoA synthetase, long-chain fatty acid:CoA ligase 2266791 fadD8 1210296 fadD8 Streptomyces avermitilis MA-4680 acyl-CoA synthetase, long-chain fatty acid:CoA ligase NP_823024.1 2264965 D 227882 CDS NP_823025.1 29828391 1213328 2267015..2267851 1 NC_003155.4 PF00248: Aldo/keto reductase family; oxidoreductase 2267851 1213328 SAV_1849 Streptomyces avermitilis MA-4680 oxidoreductase NP_823025.1 2267015 D 227882 CDS NP_823026.1 29828392 1213329 2268155..2268856 1 NC_003155.4 PF07335: Fungal chitosanase; protein 2268856 1213329 SAV_1850 Streptomyces avermitilis MA-4680 protein NP_823026.1 2268155 D 227882 CDS NP_823027.1 29828393 1213330 complement(2268934..2269635) 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 2269635 1213330 SAV_1851 Streptomyces avermitilis MA-4680 dehydrogenase NP_823027.1 2268934 R 227882 CDS NP_823028.1 29828394 1213331 complement(2269812..2270690) 1 NC_003155.4 hypothetical protein 2270690 1213331 SAV_1852 Streptomyces avermitilis MA-4680 hypothetical protein NP_823028.1 2269812 R 227882 CDS NP_823029.1 29828395 1210297 complement(2270907..2272616) 1 NC_003155.4 cellulose 1,4-beta-cellobiosidase 2272616 guxA2 1210297 guxA2 Streptomyces avermitilis MA-4680 cellulose 1,4-beta-cellobiosidase NP_823029.1 2270907 R 227882 CDS NP_823030.1 29828396 1210298 complement(2272630..2274108) 1 NC_003155.4 endo-1,4-beta-glucanase 2274108 celA2 1210298 celA2 Streptomyces avermitilis MA-4680 endo-1,4-beta-glucanase NP_823030.1 2272630 R 227882 CDS NP_823031.1 29828397 1210299 2274373..2277294 1 NC_003155.4 cellulose 1,4-beta-cellobiosidase 2277294 guxA3 1210299 guxA3 Streptomyces avermitilis MA-4680 cellulose 1,4-beta-cellobiosidase NP_823031.1 2274373 D 227882 CDS NP_823032.1 29828398 1210300 2277394..2280042 1 NC_003155.4 endo-1,4-beta-glucanase 2280042 celA3 1210300 celA3 Streptomyces avermitilis MA-4680 endo-1,4-beta-glucanase NP_823032.1 2277394 D 227882 CDS NP_823033.1 29828399 1213332 complement(2281132..2283006) 1 NC_003155.4 rhamnogalacturonan lyase 2283006 1213332 SAV_1857 Streptomyces avermitilis MA-4680 rhamnogalacturonan lyase NP_823033.1 2281132 R 227882 CDS NP_823034.1 29828400 1210301 complement(2283348..2283653) 1 NC_003155.4 4-alpha-hydroxytetrahydrobiopterin dehydratase activity; catalyzes the formation of (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7, 8-dihydro-6H-pterin from (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7, 8-tetrahydro-4a-hydroxypterin; functions in recycling tetrahydrobiopterin (BH4) in phenylalanine hydroxylase reaction; pterin-4-alpha-carbinolamine dehydratase 2283653 phhB 1210301 phhB Streptomyces avermitilis MA-4680 pterin-4-alpha-carbinolamine dehydratase NP_823034.1 2283348 R 227882 CDS NP_823035.1 29828401 1210302 complement(2283712..2284779) 1 NC_003155.4 ADP-ribosylglycohydrolase 2284779 draG1 1210302 draG1 Streptomyces avermitilis MA-4680 ADP-ribosylglycohydrolase NP_823035.1 2283712 R 227882 CDS NP_823036.1 29828402 1213333 2284808..2285665 1 NC_003155.4 DNA-binding protein 2285665 1213333 SAV_1860 Streptomyces avermitilis MA-4680 DNA-binding protein NP_823036.1 2284808 D 227882 CDS NP_823037.1 29828403 1213334 2285819..2286682 1 NC_003155.4 DNA-binding protein 2286682 1213334 SAV_1861 Streptomyces avermitilis MA-4680 DNA-binding protein NP_823037.1 2285819 D 227882 CDS NP_823038.1 29828404 1213335 complement(2286988..2287413) 1 NC_003155.4 ATP/GTP-binding protein 2287413 1213335 SAV_1862 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_823038.1 2286988 R 227882 CDS NP_823039.1 29828405 1213336 2287656..2288348 1 NC_003155.4 hypothetical protein 2288348 1213336 SAV_1863 Streptomyces avermitilis MA-4680 hypothetical protein NP_823039.1 2287656 D 227882 CDS NP_823040.1 29828406 1213337 2289461..2290849 1 NC_003155.4 PF00092: von Willebrand factor type A domain; hypothetical protein 2290849 1213337 SAV_1864 Streptomyces avermitilis MA-4680 hypothetical protein NP_823040.1 2289461 D 227882 CDS NP_823041.1 29828407 1213338 complement(2290934..2291254) 1 NC_003155.4 hypothetical protein 2291254 1213338 SAV_1865 Streptomyces avermitilis MA-4680 hypothetical protein NP_823041.1 2290934 R 227882 CDS NP_823042.1 29828408 1213339 complement(2291726..2293855) 1 NC_003155.4 hypothetical protein 2293855 1213339 SAV_1866 Streptomyces avermitilis MA-4680 hypothetical protein NP_823042.1 2291726 R 227882 CDS NP_823043.1 29828409 1213340 complement(2293994..2294419) 1 NC_003155.4 hypothetical protein 2294419 1213340 SAV_1867 Streptomyces avermitilis MA-4680 hypothetical protein NP_823043.1 2293994 R 227882 CDS NP_823044.1 29828410 1213341 2294521..2295288 1 NC_003155.4 PF00753: Metallo-beta-lactamase superfamily; hypothetical protein 2295288 1213341 SAV_1868 Streptomyces avermitilis MA-4680 hypothetical protein NP_823044.1 2294521 D 227882 CDS NP_823045.1 29828411 1213342 2295335..2295958 1 NC_003155.4 PF00597: DedA family; integral membrane protein 2295958 1213342 SAV_1869 Streptomyces avermitilis MA-4680 integral membrane protein NP_823045.1 2295335 D 227882 CDS NP_823046.1 29828412 1213343 complement(2296065..2297234) 1 NC_003155.4 PF00753: Metallo-beta-lactamase superfamily; hypothetical protein 2297234 1213343 SAV_1870 Streptomyces avermitilis MA-4680 hypothetical protein NP_823046.1 2296065 R 227882 CDS NP_823047.1 29828413 1213344 complement(2297231..2298556) 1 NC_003155.4 hypothetical protein 2298556 1213344 SAV_1871 Streptomyces avermitilis MA-4680 hypothetical protein NP_823047.1 2297231 R 227882 CDS NP_823048.1 29828414 1213345 complement(2298642..2299712) 1 NC_003155.4 hypothetical protein 2299712 1213345 SAV_1872 Streptomyces avermitilis MA-4680 hypothetical protein NP_823048.1 2298642 R 227882 CDS NP_823049.1 29828415 1210303 complement(2300101..2300895) 1 NC_003155.4 RNA polymerase alternative sigma factor; RNA polymerase sigma factor 2300895 sig19 1210303 sig19 Streptomyces avermitilis MA-4680 RNA polymerase sigma factor NP_823049.1 2300101 R 227882 CDS NP_823050.1 29828416 1213346 2301229..2301639 1 NC_003155.4 hypothetical protein 2301639 1213346 SAV_1874 Streptomyces avermitilis MA-4680 hypothetical protein NP_823050.1 2301229 D 227882 CDS NP_823051.1 29828417 1213347 2301742..2302188 1 NC_003155.4 PF00571: CBS domain; oxidoreductase 2302188 1213347 SAV_1875 Streptomyces avermitilis MA-4680 oxidoreductase NP_823051.1 2301742 D 227882 CDS NP_823052.1 29828418 1213348 2302227..2302772 1 NC_003155.4 PF01965: DJ-1/PfpI family; intracellular protease/amidase 2302772 pfpI1 1213348 pfpI1 Streptomyces avermitilis MA-4680 intracellular protease/amidase NP_823052.1 2302227 D 227882 CDS NP_823053.1 29828419 1213349 complement(2302968..2303285) 1 NC_003155.4 hypothetical protein 2303285 1213349 SAV_1877 Streptomyces avermitilis MA-4680 hypothetical protein NP_823053.1 2302968 R 227882 CDS NP_823054.1 29828420 1213350 complement(2303415..2305034) 1 NC_003155.4 ABC transporter ATP-binding protein 2305034 1213350 SAV_1878 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_823054.1 2303415 R 227882 CDS NP_823055.1 29828421 1213351 2305147..2306640 1 NC_003155.4 PF01569: PAP2 superfamily; hypothetical protein 2306640 1213351 SAV_1879 Streptomyces avermitilis MA-4680 hypothetical protein NP_823055.1 2305147 D 227882 CDS NP_823056.1 29828422 1213352 2306776..2307597 1 NC_003155.4 UbiE family methyltransferase 2307597 1213352 SAV_1880 Streptomyces avermitilis MA-4680 UbiE family methyltransferase NP_823056.1 2306776 D 227882 CDS NP_823057.1 29828423 1210304 complement(2307611..2307895) 1 NC_003155.4 gas vesicle synthesis protein 2307895 gvpK2 1210304 gvpK2 Streptomyces avermitilis MA-4680 gas vesicle synthesis protein NP_823057.1 2307611 R 227882 CDS NP_823058.1 29828424 1210305 complement(2307892..2308086) 1 NC_003155.4 gas vesicle synthesis protein 2308086 gvpS2 1210305 gvpS2 Streptomyces avermitilis MA-4680 gas vesicle synthesis protein NP_823058.1 2307892 R 227882 CDS NP_823059.1 29828425 1210306 complement(2308083..2308850) 1 NC_003155.4 gas vesicle synthesis protein 2308850 gvpL2 1210306 gvpL2 Streptomyces avermitilis MA-4680 gas vesicle synthesis protein NP_823059.1 2308083 R 227882 CDS NP_823060.1 29828426 1210307 complement(2308847..2309173) 1 NC_003155.4 gas vesicle synthesis protein 2309173 gvpJ2 1210307 gvpJ2 Streptomyces avermitilis MA-4680 gas vesicle synthesis protein NP_823060.1 2308847 R 227882 CDS NP_823061.1 29828427 1213353 complement(2309170..2310306) 1 NC_003155.4 PF03364: Streptomyces cyclase/dehydrase; hypothetical protein 2310306 1213353 SAV_1885 Streptomyces avermitilis MA-4680 hypothetical protein NP_823061.1 2309170 R 227882 CDS NP_823062.1 29828428 1213354 complement(2310299..2310985) 1 NC_003155.4 hypothetical protein 2310985 1213354 SAV_1886 Streptomyces avermitilis MA-4680 hypothetical protein NP_823062.1 2310299 R 227882 CDS NP_823063.1 29828429 1210308 complement(2310982..2311245) 1 NC_003155.4 gas vesicle synthesis protein 2311245 gvpG2 1210308 gvpG2 Streptomyces avermitilis MA-4680 gas vesicle synthesis protein NP_823063.1 2310982 R 227882 CDS NP_823064.1 29828430 1210309 complement(2311286..2312053) 1 NC_003155.4 gas vesicle synthesis protein 2312053 gvpF2 1210309 gvpF2 Streptomyces avermitilis MA-4680 gas vesicle synthesis protein NP_823064.1 2311286 R 227882 CDS NP_823065.1 29828431 1210310 complement(2312050..2312475) 1 NC_003155.4 similar to the gas vesicle synthesis protein GvpA in other bacteria but contains an extended C-terminal tail; function in the Streptomyces group is unknown but they contain several homologs of other gas vesicle synthesis proteins; gas vesicle synthesis-like protein 2312475 gvpA2 1210310 gvpA2 Streptomyces avermitilis MA-4680 gas vesicle synthesis-like protein NP_823065.1 2312050 R 227882 CDS NP_823066.1 29828432 1210311 complement(2312532..2312879) 1 NC_003155.4 gas vesicle synthesis protein 2312879 gvpO2 1210311 gvpO2 Streptomyces avermitilis MA-4680 gas vesicle synthesis protein NP_823066.1 2312532 R 227882 CDS NP_823067.1 29828433 1210312 complement(2313083..2314933) 1 NC_003155.4 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 2314933 tkt3 1210312 tkt3 Streptomyces avermitilis MA-4680 transketolase NP_823067.1 2313083 R 227882 CDS NP_823068.1 29828434 1213355 complement(2314930..2316291) 1 NC_003155.4 PF00070: Pyridine nucleotide-disulphide oxidoreductase; NADH dehydrogenase 2316291 ndh1 1213355 ndh1 Streptomyces avermitilis MA-4680 NADH dehydrogenase NP_823068.1 2314930 R 227882 CDS NP_823069.1 29828435 1213356 complement(2316560..2317171) 1 NC_003155.4 PF07332: Protein of unknown function (DUF1469); hypothetical protein 2317171 1213356 SAV_1893 Streptomyces avermitilis MA-4680 hypothetical protein NP_823069.1 2316560 R 227882 CDS NP_823070.1 29828436 1213357 2317239..2317592 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein 2317592 1213357 SAV_1894 Streptomyces avermitilis MA-4680 hypothetical protein NP_823070.1 2317239 D 227882 CDS NP_823071.1 29828437 1213358 complement(2317670..2318566) 1 NC_003155.4 arginase 2318566 argI 1213358 argI Streptomyces avermitilis MA-4680 arginase NP_823071.1 2317670 R 227882 CDS NP_823072.1 29828438 1213359 complement(2318593..2319135) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 2319135 1213359 SAV_1896 Streptomyces avermitilis MA-4680 acetyltransferase NP_823072.1 2318593 R 227882 CDS NP_823073.1 29828439 1213360 complement(2319187..2320119) 1 NC_003155.4 PF02016: LD-carboxypeptidase; carboxylpeptidase 2320119 1213360 SAV_1897 Streptomyces avermitilis MA-4680 carboxylpeptidase NP_823073.1 2319187 R 227882 CDS NP_823074.1 29828440 1213361 complement(2320116..2322116) 1 NC_003155.4 PF00326: Prolyl oligopeptidase family; acyl-peptide hydrolase 2322116 1213361 SAV_1898 Streptomyces avermitilis MA-4680 acyl-peptide hydrolase NP_823074.1 2320116 R 227882 CDS NP_823075.1 29828441 1213362 complement(2322130..2323452) 1 NC_003155.4 PF01546: Peptidase family M20/M25/M40; hypothetical protein 2323452 1213362 SAV_1899 Streptomyces avermitilis MA-4680 hypothetical protein NP_823075.1 2322130 R 227882 CDS NP_823076.1 29828442 1213363 complement(2323445..2324278) 1 NC_003155.4 PF04951: D-aminopeptidase; D-aminopeptidase 2324278 1213363 SAV_1900 Streptomyces avermitilis MA-4680 D-aminopeptidase NP_823076.1 2323445 R 227882 CDS NP_823077.1 29828443 1213364 complement(2324383..2325108) 1 NC_003155.4 PF05724: Thiopurine S-methyltransferase (TPMT); hypothetical protein 2325108 1213364 SAV_1901 Streptomyces avermitilis MA-4680 hypothetical protein NP_823077.1 2324383 R 227882 CDS NP_823078.1 29828444 1213365 complement(2325246..2327708) 1 NC_003155.4 PF07228: Stage II sporulation protein E (SpoIIE); hypothetical protein 2327708 1213365 SAV_1902 Streptomyces avermitilis MA-4680 hypothetical protein NP_823078.1 2325246 R 227882 CDS NP_823079.1 29828445 1213366 complement(2327906..2330284) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 2330284 1213366 SAV_1903 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_823079.1 2327906 R 227882 CDS NP_823080.1 29828446 1213367 complement(2330438..2330881) 1 NC_003155.4 PF03364: Streptomyces cyclase/dehydrase; hypothetical protein 2330881 1213367 SAV_1904 Streptomyces avermitilis MA-4680 hypothetical protein NP_823080.1 2330438 R 227882 CDS NP_823081.1 29828447 1213368 2331042..2332082 1 NC_003155.4 PF04055: Radical SAM superfamily; hypothetical protein 2332082 1213368 SAV_1905 Streptomyces avermitilis MA-4680 hypothetical protein NP_823081.1 2331042 D 227882 CDS NP_823082.1 29828448 1213369 2332219..2333796 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; peptidase 2333796 1213369 SAV_1906 Streptomyces avermitilis MA-4680 peptidase NP_823082.1 2332219 D 227882 CDS NP_823083.1 29828449 1213370 2333984..2334619 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 2334619 1213370 SAV_1907 Streptomyces avermitilis MA-4680 acetyltransferase NP_823083.1 2333984 D 227882 CDS NP_823084.1 29828450 1213371 complement(2334531..2335139) 1 NC_003155.4 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 2335139 prpL2 1213371 prpL2 Streptomyces avermitilis MA-4680 adenylosuccinate lyase NP_823084.1 2334531 R 227882 CDS NP_823085.1 29828451 1210313 2335501..2337306 1 NC_003155.4 PF02737: 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; 3-hydroxyacyl-CoA dehydrogenase 2337306 fadC1 1210313 fadC1 Streptomyces avermitilis MA-4680 3-hydroxyacyl-CoA dehydrogenase NP_823085.1 2335501 D 227882 CDS NP_823086.1 29828452 1213372 2337443..2338258 1 NC_003155.4 TetR family transcriptional regulator 2338258 1213372 SAV_1910 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_823086.1 2337443 D 227882 CDS NP_823087.1 29828453 1210314 2338670..2340007 1 NC_003155.4 crotonyl-CoA reductase 2340007 ccrA2 1210314 ccrA2 Streptomyces avermitilis MA-4680 crotonyl-CoA reductase NP_823087.1 2338670 D 227882 CDS NP_823088.1 29828454 1210315 2340018..2342066 1 NC_003155.4 methylmalonyl-CoA mutase, coenzyme B12-dependent alpha subunit 2342066 meaA1 1210315 meaA1 Streptomyces avermitilis MA-4680 methylmalonyl-CoA mutase, coenzyme B12-dependent alpha subunit NP_823088.1 2340018 D 227882 CDS NP_823089.1 29828455 1213373 2342063..2343028 1 NC_003155.4 citrate lyase beta chain 2343028 citE2 1213373 citE2 Streptomyces avermitilis MA-4680 citrate lyase beta chain NP_823089.1 2342063 D 227882 CDS NP_823090.1 29828456 1213374 2343034..2343561 1 NC_003155.4 PF01575: MaoC like domain; hypothetical protein 2343561 1213374 SAV_1914 Streptomyces avermitilis MA-4680 hypothetical protein NP_823090.1 2343034 D 227882 CDS NP_823091.1 29828457 1210316 2343564..2344769 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 2344769 fadE5 1210316 fadE5 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_823091.1 2343564 D 227882 CDS NP_823092.1 29828458 1213375 2344940..2345587 1 NC_003155.4 catalyzes the decarboxylaton of phospatidyl-L-sering to phosphatidylethanolamine; phosphatidylserine decarboxylase 2345587 psd 1213375 psd Streptomyces avermitilis MA-4680 phosphatidylserine decarboxylase NP_823092.1 2344940 D 227882 CDS NP_823093.1 29828459 1210317 2345646..2346428 1 NC_003155.4 PF01066: CDP-alcohol phosphatidyltransferase; phosphatidylserine synthase 2346428 pssA 1210317 pssA Streptomyces avermitilis MA-4680 phosphatidylserine synthase NP_823093.1 2345646 D 227882 CDS NP_823094.1 29828460 1213376 complement(2346527..2347678) 1 NC_003155.4 glycerate kinase 2347678 glxK 1213376 glxK Streptomyces avermitilis MA-4680 glycerate kinase NP_823094.1 2346527 R 227882 CDS NP_823095.1 29828461 1213377 2347825..2348958 1 NC_003155.4 PF03747: ADP-ribosylglycohydrolase; hypothetical protein 2348958 1213377 SAV_1919 Streptomyces avermitilis MA-4680 hypothetical protein NP_823095.1 2347825 D 227882 CDS NP_823096.1 29828462 1213378 2349134..2349628 1 NC_003155.4 PF00293: NUDIX domain; hypothetical protein 2349628 1213378 SAV_1920 Streptomyces avermitilis MA-4680 hypothetical protein NP_823096.1 2349134 D 227882 CDS NP_823097.1 29828463 1213379 2350196..2350636 1 NC_003155.4 integral membrane protein 2350636 1213379 SAV_1921 Streptomyces avermitilis MA-4680 integral membrane protein NP_823097.1 2350196 D 227882 CDS NP_823098.1 29828464 1210318 2350818..2351657 1 NC_003155.4 glucose 1-dehydrogenase 2351657 gdh 1210318 gdh Streptomyces avermitilis MA-4680 glucose 1-dehydrogenase NP_823098.1 2350818 D 227882 CDS NP_823099.1 29828465 1210319 2352169..2353203 1 NC_003155.4 frameshift; cytochrome bd-I oxidase subunit I 2353203 cydA2 1210319 cydA2 Streptomyces avermitilis MA-4680 cytochrome bd-I oxidase subunit I NP_823099.1 2352169 D 227882 CDS NP_823100.1 29828466 1210320 2353200..2354249 1 NC_003155.4 cytochrome bd-I oxidase subunit II 2354249 cydB2 1210320 cydB2 Streptomyces avermitilis MA-4680 cytochrome bd-I oxidase subunit II NP_823100.1 2353200 D 227882 CDS NP_823101.1 29828467 1213380 2354246..2354812 1 NC_003155.4 gluconokinase 2354812 gntK1 1213380 gntK1 Streptomyces avermitilis MA-4680 gluconokinase NP_823101.1 2354246 D 227882 CDS NP_823102.1 29828468 1213381 complement(2354964..2355419) 1 NC_003155.4 PF01839: FG-GAP repeat; hypothetical protein 2355419 1213381 SAV_1926 Streptomyces avermitilis MA-4680 hypothetical protein NP_823102.1 2354964 R 227882 CDS NP_823103.1 29828469 1213382 2355609..2356976 1 NC_003155.4 integral membrane protein 2356976 1213382 SAV_1927 Streptomyces avermitilis MA-4680 integral membrane protein NP_823103.1 2355609 D 227882 CDS NP_823104.1 29828470 1213383 complement(2356960..2357916) 1 NC_003155.4 PF04087: Domain of unknown function (DUF389); integral membrane protein 2357916 1213383 SAV_1928 Streptomyces avermitilis MA-4680 integral membrane protein NP_823104.1 2356960 R 227882 CDS NP_823105.1 29828471 1213384 2358051..2358983 1 NC_003155.4 PF04199: Putative cyclase; cyclase 2358983 1213384 SAV_1929 Streptomyces avermitilis MA-4680 cyclase NP_823105.1 2358051 D 227882 CDS NP_823106.1 29828472 1213385 2359062..2360699 1 NC_003155.4 PF00732: GMC oxidoreductase; choline dehydrogenase 2360699 chd 1213385 chd Streptomyces avermitilis MA-4680 choline dehydrogenase NP_823106.1 2359062 D 227882 CDS NP_823107.1 29828473 1213386 2360696..2362114 1 NC_003155.4 hypothetical protein 2362114 1213386 SAV_1931 Streptomyces avermitilis MA-4680 hypothetical protein NP_823107.1 2360696 D 227882 CDS NP_823108.1 29828474 1213387 2362140..2363957 1 NC_003155.4 PF00723: Glycosyl hydrolases family 15; glycosyl hydrolase 2363957 1213387 SAV_1932 Streptomyces avermitilis MA-4680 glycosyl hydrolase NP_823108.1 2362140 D 227882 CDS NP_823109.1 29828475 1210321 complement(2363976..2364458) 1 NC_003155.4 methylated-DNA--protein-cysteine S-methyltransferase 2364458 ogt1 1210321 ogt1 Streptomyces avermitilis MA-4680 methylated-DNA--protein-cysteine S-methyltransferase NP_823109.1 2363976 R 227882 CDS NP_823110.1 29828476 1210322 complement(2364468..2365934) 1 NC_003155.4 PF06029: AlkA N-terminal domain; ADA-like regulatory protein 2365934 alkA1 1210322 alkA1 Streptomyces avermitilis MA-4680 ADA-like regulatory protein NP_823110.1 2364468 R 227882 CDS NP_823111.1 29828477 1213388 complement(2366193..2367722) 1 NC_003155.4 PF00355: Rieske [2Fe-2S] domain; iron-sulfur binding oxidoreductase 2367722 1213388 SAV_1935 Streptomyces avermitilis MA-4680 iron-sulfur binding oxidoreductase NP_823111.1 2366193 R 227882 CDS NP_823112.1 29828478 1213389 complement(2368372..2369790) 1 NC_003155.4 PF01593: Flavin containing amine oxidoreductase; dehydrogenase 2369790 1213389 SAV_1936 Streptomyces avermitilis MA-4680 dehydrogenase NP_823112.1 2368372 R 227882 CDS NP_823113.1 29828479 1213390 complement(2369954..2370799) 1 NC_003155.4 PF00459: Inositol monophosphatase family; inositol monophosphatase 2370799 1213390 SAV_1937 Streptomyces avermitilis MA-4680 inositol monophosphatase NP_823113.1 2369954 R 227882 CDS NP_823114.1 29828480 1213391 complement(2370885..2372822) 1 NC_003155.4 PF01019: Gamma-glutamyltranspeptidase; gamma-glutamyltranspeptidase 2372822 ggt1 1213391 ggt1 Streptomyces avermitilis MA-4680 gamma-glutamyltranspeptidase NP_823114.1 2370885 R 227882 CDS NP_823115.1 29828481 1213392 2373040..2373903 1 NC_003155.4 hypothetical protein 2373903 1213392 SAV_1939 Streptomyces avermitilis MA-4680 hypothetical protein NP_823115.1 2373040 D 227882 CDS NP_823116.1 29828482 1213393 complement(2373980..2374411) 1 NC_003155.4 hypothetical protein 2374411 1213393 SAV_1940 Streptomyces avermitilis MA-4680 hypothetical protein NP_823116.1 2373980 R 227882 CDS NP_823117.1 29828483 1213394 complement(2374703..2375866) 1 NC_003155.4 Catalyzes the reversible two-electron oxidation of formate to carbon dioxide. It allows the assimilation of carbon dioxide and provides energy for growth through oxidative phosphorylation coupled to the reduction of oxygen, nitrate, sulphate or fumarate; formate dehydrogenase 2375866 fdh 1213394 fdh Streptomyces avermitilis MA-4680 formate dehydrogenase NP_823117.1 2374703 R 227882 CDS NP_823118.1 29828484 1213395 2376076..2376690 1 NC_003155.4 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 2376690 ccrB 1213395 ccrB Streptomyces avermitilis MA-4680 camphor resistance protein CrcB NP_823118.1 2376076 D 227882 CDS YP_001621482.1 162960848 5815323 2376687..2377058 1 NC_003155.4 putative camphor resistance protein CrcB 2377058 crcB4 5815323 crcB4 Streptomyces avermitilis MA-4680 putative camphor resistance protein CrcB YP_001621482.1 2376687 D 227882 CDS NP_823119.1 29828485 1213396 2377711..2378349 1 NC_003155.4 amidate substrates transporter protein 2378349 1213396 SAV_1943 Streptomyces avermitilis MA-4680 amidate substrates transporter protein NP_823119.1 2377711 D 227882 CDS NP_823120.1 29828486 1213397 2378374..2379624 1 NC_003155.4 acetamidase 2379624 1213397 SAV_1944 Streptomyces avermitilis MA-4680 acetamidase NP_823120.1 2378374 D 227882 CDS NP_823121.1 29828487 1213398 complement(2379723..2380619) 1 NC_003155.4 hypothetical protein 2380619 1213398 SAV_1945 Streptomyces avermitilis MA-4680 hypothetical protein NP_823121.1 2379723 R 227882 CDS NP_823122.1 29828488 1213399 2380833..2381501 1 NC_003155.4 hypothetical protein 2381501 1213399 SAV_1946 Streptomyces avermitilis MA-4680 hypothetical protein NP_823122.1 2380833 D 227882 CDS NP_823123.1 29828489 1213400 complement(2381561..2383102) 1 NC_003155.4 allantoin permease 2383102 1213400 SAV_1947 Streptomyces avermitilis MA-4680 allantoin permease NP_823123.1 2381561 R 227882 CDS NP_823124.1 29828490 1213401 complement(2383259..2384284) 1 NC_003155.4 N5,N10-methylene- tetrahydromethanopterin reductase 2384284 1213401 SAV_1948 Streptomyces avermitilis MA-4680 N5,N10-methylene- tetrahydromethanopterin reductase NP_823124.1 2383259 R 227882 CDS NP_823125.1 29828491 1213402 complement(2384296..2385696) 1 NC_003155.4 catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position; phenylhydantoinase 2385696 dht 1213402 dht Streptomyces avermitilis MA-4680 phenylhydantoinase NP_823125.1 2384296 R 227882 CDS NP_823126.1 29828492 1213403 complement(2385800..2386642) 1 NC_003155.4 PF00795: Carbon-nitrogen hydrolase; hydrolase 2386642 1213403 SAV_1950 Streptomyces avermitilis MA-4680 hydrolase NP_823126.1 2385800 R 227882 CDS NP_823127.1 29828493 1213404 complement(2386791..2388350) 1 NC_003155.4 regulatory protein 2388350 1213404 SAV_1951 Streptomyces avermitilis MA-4680 regulatory protein NP_823127.1 2386791 R 227882 CDS NP_823128.1 29828494 1213405 complement(2388408..2389688) 1 NC_003155.4 aminotransferase 2389688 1213405 SAV_1952 Streptomyces avermitilis MA-4680 aminotransferase NP_823128.1 2388408 R 227882 CDS NP_823129.1 29828495 1213406 complement(2389685..2390527) 1 NC_003155.4 PF00795: Carbon-nitrogen hydrolase; hydrolase 2390527 1213406 SAV_1953 Streptomyces avermitilis MA-4680 hydrolase NP_823129.1 2389685 R 227882 CDS NP_823130.1 29828496 1213407 complement(2390738..2392417) 1 NC_003155.4 PF01391: Collagen triple helix repeat (20 copies); hypothetical protein 2392417 1213407 SAV_1954 Streptomyces avermitilis MA-4680 hypothetical protein NP_823130.1 2390738 R 227882 CDS NP_823131.1 29828497 1213408 complement(2392503..2392760) 1 NC_003155.4 DNA-binding protein 2392760 1213408 SAV_1955 Streptomyces avermitilis MA-4680 DNA-binding protein NP_823131.1 2392503 R 227882 CDS NP_823132.1 29828498 1213409 2392839..2393624 1 NC_003155.4 PF00557: metallopeptidase family M24; methionine aminopeptidase 2393624 map1 1213409 map1 Streptomyces avermitilis MA-4680 methionine aminopeptidase NP_823132.1 2392839 D 227882 CDS NP_823133.1 29828499 1210323 complement(2393820..2395619) 1 NC_003155.4 PF01019: Gamma-glutamyltranspeptidase; gamma-glutamyltranspeptidase 2395619 ggt2 1210323 ggt2 Streptomyces avermitilis MA-4680 gamma-glutamyltranspeptidase NP_823133.1 2393820 R 227882 CDS NP_823134.1 29828500 1213410 2395725..2396480 1 NC_003155.4 protein 2396480 1213410 SAV_1958 Streptomyces avermitilis MA-4680 protein NP_823134.1 2395725 D 227882 CDS NP_823135.1 29828501 1213411 2396597..2398165 1 NC_003155.4 PF02129: X-Pro dipeptidyl-peptidase (S15 family); acyl esterase 2398165 1213411 SAV_1959 Streptomyces avermitilis MA-4680 acyl esterase NP_823135.1 2396597 D 227882 CDS NP_823136.1 29828502 1210324 complement(2398214..2399104) 1 NC_003155.4 ABC transporter permease; glutamate transporter permease 2399104 gluD1 1210324 gluD1 Streptomyces avermitilis MA-4680 glutamate transporter permease NP_823136.1 2398214 R 227882 CDS NP_823137.1 29828503 1210325 complement(2399101..2399745) 1 NC_003155.4 ABC transporter permease; glutamate transporter permease 2399745 gluC1 1210325 gluC1 Streptomyces avermitilis MA-4680 glutamate transporter permease NP_823137.1 2399101 R 227882 CDS NP_823138.1 29828504 1210326 complement(2399757..2400674) 1 NC_003155.4 ABC transporter substrate-binding protein; glutamate binding periplasmic protein 2400674 gluB1 1210326 gluB1 Streptomyces avermitilis MA-4680 glutamate binding periplasmic protein NP_823138.1 2399757 R 227882 CDS NP_823139.1 29828505 1210327 complement(2400693..2401454) 1 NC_003155.4 ABC transporter ATP-binding protein; glutamate uptake system ATP-binding protein 2401454 gluA1 1210327 gluA1 Streptomyces avermitilis MA-4680 glutamate uptake system ATP-binding protein NP_823139.1 2400693 R 227882 CDS NP_823140.1 29828506 1213412 complement(2401552..2401992) 1 NC_003155.4 hypothetical protein 2401992 1213412 SAV_1964 Streptomyces avermitilis MA-4680 hypothetical protein NP_823140.1 2401552 R 227882 CDS NP_823141.1 29828507 1213413 2402200..2403963 1 NC_003155.4 PF00657: GDSL-like Lipase/Acylhydrolase; protein 2403963 1213413 SAV_1965 Streptomyces avermitilis MA-4680 protein NP_823141.1 2402200 D 227882 CDS NP_823142.1 29828508 1210328 complement(2403970..2404758) 1 NC_003155.4 exonuclease 2404758 xthA 1210328 xthA Streptomyces avermitilis MA-4680 exonuclease NP_823142.1 2403970 R 227882 CDS NP_823143.1 29828509 1213414 complement(2404839..2405474) 1 NC_003155.4 PF00753: Metallo-beta-lactamase superfamily; hypothetical protein 2405474 1213414 SAV_1967 Streptomyces avermitilis MA-4680 hypothetical protein NP_823143.1 2404839 R 227882 CDS NP_823144.1 29828510 1213415 complement(2405547..2406842) 1 NC_003155.4 PF02627: Carboxymuconolactone decarboxylase family; 3-oxoadipate enol-lactone hydrolase 2406842 pcaL2 1213415 pcaL2 Streptomyces avermitilis MA-4680 3-oxoadipate enol-lactone hydrolase NP_823144.1 2405547 R 227882 CDS NP_823145.1 29828511 1213416 complement(2406875..2407447) 1 NC_003155.4 IS110 family; IS110 family transposase 2407447 1213416 SAV_1969 Streptomyces avermitilis MA-4680 IS110 family transposase NP_823145.1 2406875 R 227882 CDS NP_823146.1 29828512 1213417 complement(2407717..2408478) 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 2408478 1213417 SAV_1970 Streptomyces avermitilis MA-4680 dehydrogenase NP_823146.1 2407717 R 227882 CDS NP_823147.1 29828513 1213418 2408669..2409541 1 NC_003155.4 DNA-binding protein 2409541 1213418 SAV_1971 Streptomyces avermitilis MA-4680 DNA-binding protein NP_823147.1 2408669 D 227882 CDS NP_823148.1 29828514 1213419 complement(2409621..2409863) 1 NC_003155.4 hypothetical protein 2409863 1213419 SAV_1972 Streptomyces avermitilis MA-4680 hypothetical protein NP_823148.1 2409621 R 227882 CDS NP_823149.1 29828515 1213420 complement(2410108..2410929) 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 2410929 1213420 SAV_1973 Streptomyces avermitilis MA-4680 hydrolase NP_823149.1 2410108 R 227882 CDS NP_823150.1 29828516 1213421 complement(2411322..2412089) 1 NC_003155.4 PF00557: metallopeptidase family M24; methionine aminopeptidase 2412089 map2 1213421 map2 Streptomyces avermitilis MA-4680 methionine aminopeptidase NP_823150.1 2411322 R 227882 CDS NP_823151.1 29828517 1213422 2412155..2412460 1 NC_003155.4 DNA-binding protein 2412460 1213422 SAV_1975 Streptomyces avermitilis MA-4680 DNA-binding protein NP_823151.1 2412155 D 227882 CDS NP_823152.1 29828518 1213423 complement(2412485..2412787) 1 NC_003155.4 hypothetical protein 2412787 1213423 SAV_1976 Streptomyces avermitilis MA-4680 hypothetical protein NP_823152.1 2412485 R 227882 CDS NP_823153.1 29828519 1213424 complement(2413020..2415392) 1 NC_003155.4 PF04434: SWIM zinc finger; hypothetical protein 2415392 1213424 SAV_1977 Streptomyces avermitilis MA-4680 hypothetical protein NP_823153.1 2413020 R 227882 CDS NP_823154.1 29828520 1210329 complement(2415389..2418277) 1 NC_003155.4 SNF2/RAD54 family helicase 2418277 helZ3 1210329 helZ3 Streptomyces avermitilis MA-4680 SNF2/RAD54 family helicase NP_823154.1 2415389 R 227882 CDS NP_823155.1 29828521 1213425 complement(2418373..2418957) 1 NC_003155.4 hypothetical protein 2418957 1213425 SAV_1979 Streptomyces avermitilis MA-4680 hypothetical protein NP_823155.1 2418373 R 227882 CDS NP_823156.1 29828522 1213426 complement(2418954..2420099) 1 NC_003155.4 sugar kinase 2420099 1213426 SAV_1980 Streptomyces avermitilis MA-4680 sugar kinase NP_823156.1 2418954 R 227882 CDS NP_823157.1 29828523 1213427 complement(2420149..2420991) 1 NC_003155.4 sugar ABC transporter ATP-binding protein 2420991 1213427 SAV_1981 Streptomyces avermitilis MA-4680 sugar ABC transporter ATP-binding protein NP_823157.1 2420149 R 227882 CDS NP_823158.1 29828524 1213428 complement(2420988..2422019) 1 NC_003155.4 sugar ABC transporter permease 2422019 1213428 SAV_1982 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_823158.1 2420988 R 227882 CDS NP_823159.1 29828525 1213429 complement(2422016..2423020) 1 NC_003155.4 sugar ABC substrate-bindig protein 2423020 1213429 SAV_1983 Streptomyces avermitilis MA-4680 sugar ABC substrate-bindig protein NP_823159.1 2422016 R 227882 CDS NP_823160.1 29828526 1213430 complement(2423172..2423921) 1 NC_003155.4 PF07702: UbiC transcription regulator-associated; GntR family transcriptional regulator 2423921 1213430 SAV_1984 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_823160.1 2423172 R 227882 CDS NP_823161.1 29828527 1213431 2424038..2425048 1 NC_003155.4 PF01408: Oxidoreductase family, NAD-binding Rossmann fold; oxidoreductase 2425048 1213431 SAV_1985 Streptomyces avermitilis MA-4680 oxidoreductase NP_823161.1 2424038 D 227882 CDS NP_823162.1 29828528 1210330 complement(2425067..2425492) 1 NC_003155.4 phenylacetic acid degradation protein 2425492 paaI 1210330 paaI Streptomyces avermitilis MA-4680 phenylacetic acid degradation protein NP_823162.1 2425067 R 227882 CDS NP_823163.1 29828529 1210331 complement(2425563..2426744) 1 NC_003155.4 CYP107L2, adjacent to paaI; cytochrome P450 hydroxylase 2426744 cyp8 1210331 cyp8 Streptomyces avermitilis MA-4680 cytochrome P450 hydroxylase NP_823163.1 2425563 R 227882 CDS NP_823164.1 29828530 1213432 complement(2426786..2427457) 1 NC_003155.4 two-component system response regulator 2427457 1213432 SAV_1988 Streptomyces avermitilis MA-4680 two-component system response regulator NP_823164.1 2426786 R 227882 CDS NP_823165.1 29828531 1213433 2427604..2428632 1 NC_003155.4 similar to norsolorinic acid reductase, PF00248: Aldo/keto reductase family; aryl-alcohol dehydrogenase 2428632 1213433 SAV_1989 Streptomyces avermitilis MA-4680 aryl-alcohol dehydrogenase NP_823165.1 2427604 D 227882 CDS NP_823166.1 29828532 1213434 complement(2428735..2430174) 1 NC_003155.4 two-component system sensor kinase 2430174 1213434 SAV_1990 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_823166.1 2428735 R 227882 CDS NP_823167.1 29828533 1213435 complement(2430390..2430785) 1 NC_003155.4 PF00545: ribonuclease; guanyl-specific ribonuclease Sa3 precursor (RNase Sa3) 2430785 1213435 SAV_1991 Streptomyces avermitilis MA-4680 guanyl-specific ribonuclease Sa3 precursor (RNase Sa3) NP_823167.1 2430390 R 227882 CDS NP_823168.1 29828534 1213436 complement(2430872..2431777) 1 NC_003155.4 PF00892: Integral membrane protein DUF6; hypothetical protein 2431777 1213436 SAV_1992 Streptomyces avermitilis MA-4680 hypothetical protein NP_823168.1 2430872 R 227882 CDS NP_823169.1 29828535 1213437 complement(2431903..2432511) 1 NC_003155.4 PF01872: RibD C-terminal domain; hypothetical protein 2432511 1213437 SAV_1993 Streptomyces avermitilis MA-4680 hypothetical protein NP_823169.1 2431903 R 227882 CDS NP_823170.1 29828536 1213438 2432709..2433716 1 NC_003155.4 cation transporter 2433716 1213438 SAV_1994 Streptomyces avermitilis MA-4680 cation transporter NP_823170.1 2432709 D 227882 CDS NP_823171.1 29828537 1213439 complement(2433754..2434884) 1 NC_003155.4 catalyzes the formation of S-ureidoglycolate and urea from allantoate; allantoicase 2434884 1213439 SAV_1995 Streptomyces avermitilis MA-4680 allantoicase NP_823171.1 2433754 R 227882 CDS NP_823172.1 29828538 1210332 complement(2434954..2436291) 1 NC_003155.4 allantoinase 2436291 pucH 1210332 pucH Streptomyces avermitilis MA-4680 allantoinase NP_823172.1 2434954 R 227882 CDS NP_823173.1 29828539 1213440 2436542..2437345 1 NC_003155.4 IclR family transcriptional regulator 2437345 1213440 SAV_1997 Streptomyces avermitilis MA-4680 IclR family transcriptional regulator NP_823173.1 2436542 D 227882 CDS NP_823174.1 29828540 1213441 complement(2437674..2438168) 1 NC_003155.4 hypothetical protein 2438168 1213441 SAV_1998 Streptomyces avermitilis MA-4680 hypothetical protein NP_823174.1 2437674 R 227882 CDS NP_823175.1 29828541 1213442 2438198..2438797 1 NC_003155.4 hypothetical protein 2438797 1213442 SAV_1999 Streptomyces avermitilis MA-4680 hypothetical protein NP_823175.1 2438198 D 227882 CDS NP_823176.1 29828542 1210333 2439019..2440644 1 NC_003155.4 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle; malate synthase 2440644 aceB1 1210333 aceB1 Streptomyces avermitilis MA-4680 malate synthase NP_823176.1 2439019 D 227882 CDS NP_823177.1 29828543 1213443 complement(2440649..2440948) 1 NC_003155.4 PF05169: Selenoprotein W-related family; hypothetical protein 2440948 1213443 SAV_2001 Streptomyces avermitilis MA-4680 hypothetical protein NP_823177.1 2440649 R 227882 CDS NP_823178.1 29828544 1213444 complement(2440927..2441841) 1 NC_003155.4 hypothetical protein 2441841 1213444 SAV_2002 Streptomyces avermitilis MA-4680 hypothetical protein NP_823178.1 2440927 R 227882 CDS NP_823179.1 29828545 1213445 complement(2441883..2443400) 1 NC_003155.4 iron transport protein 2443400 1213445 SAV_2003 Streptomyces avermitilis MA-4680 iron transport protein NP_823179.1 2441883 R 227882 CDS NP_823180.1 29828546 1213446 2443486..2444994 1 NC_003155.4 iron transport protein 2444994 1213446 SAV_2004 Streptomyces avermitilis MA-4680 iron transport protein NP_823180.1 2443486 D 227882 CDS NP_823181.1 29828547 1213447 2445049..2446311 1 NC_003155.4 PF00092: von Willebrand factor type A domain; hypothetical protein 2446311 1213447 SAV_2005 Streptomyces avermitilis MA-4680 hypothetical protein NP_823181.1 2445049 D 227882 CDS NP_823182.1 29828548 1213448 2446311..2447156 1 NC_003155.4 hypothetical protein 2447156 1213448 SAV_2006 Streptomyces avermitilis MA-4680 hypothetical protein NP_823182.1 2446311 D 227882 CDS NP_823183.1 29828549 1213449 complement(2447531..2448187) 1 NC_003155.4 transcriptional regulator 2448187 1213449 SAV_2007 Streptomyces avermitilis MA-4680 transcriptional regulator NP_823183.1 2447531 R 227882 CDS NP_823184.1 29828550 1213450 2448255..2449463 1 NC_003155.4 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 2449463 aspB1 1213450 aspB1 Streptomyces avermitilis MA-4680 aminotransferase AlaT NP_823184.1 2448255 D 227882 CDS NP_823185.1 29828551 1213451 2449575..2450174 1 NC_003155.4 mutase 2450174 1213451 SAV_2009 Streptomyces avermitilis MA-4680 mutase NP_823185.1 2449575 D 227882 CDS NP_823186.1 29828552 1213452 complement(2450191..2450817) 1 NC_003155.4 hypothetical protein 2450817 1213452 SAV_2010 Streptomyces avermitilis MA-4680 hypothetical protein NP_823186.1 2450191 R 227882 CDS NP_823187.1 29828553 1213453 2450999..2451421 1 NC_003155.4 PF03061: Thioesterase superfamily; hypothetical protein 2451421 1213453 SAV_2011 Streptomyces avermitilis MA-4680 hypothetical protein NP_823187.1 2450999 D 227882 CDS NP_823188.1 29828554 1213454 complement(2451474..2451875) 1 NC_003155.4 PF01638: Transcriptional regulator; transcriptional regulator 2451875 1213454 SAV_2012 Streptomyces avermitilis MA-4680 transcriptional regulator NP_823188.1 2451474 R 227882 CDS NP_823189.1 29828555 1213455 2451977..2453437 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transport integral membrane protein 2453437 1213455 SAV_2013 Streptomyces avermitilis MA-4680 transport integral membrane protein NP_823189.1 2451977 D 227882 CDS NP_823190.1 29828556 1213456 2453633..2455819 1 NC_003155.4 alpha-N-acetylglucosaminidase 2455819 1213456 SAV_2014 Streptomyces avermitilis MA-4680 alpha-N-acetylglucosaminidase NP_823190.1 2453633 D 227882 CDS NP_823191.1 29828557 1213457 2455947..2456762 1 NC_003155.4 PF01374: Glycosyl hydrolase family 46; chitosanase 2456762 csn1 1213457 csn1 Streptomyces avermitilis MA-4680 chitosanase NP_823191.1 2455947 D 227882 CDS NP_823192.1 29828558 1213458 complement(2456869..2458329) 1 NC_003155.4 xanthine/uracil permease 2458329 pbuX2 1213458 pbuX2 Streptomyces avermitilis MA-4680 xanthine/uracil permease NP_823192.1 2456869 R 227882 CDS NP_823193.1 29828559 1213459 complement(2458527..2459906) 1 NC_003155.4 catalyzes the transformation of hydroxyatrazine to N-isopropylammelide and ethylamine in the atrazine degradation pathway.; hydroxydechloroatrazine ethylaminohydrolase 2459906 1213459 SAV_2017 Streptomyces avermitilis MA-4680 hydroxydechloroatrazine ethylaminohydrolase NP_823193.1 2458527 R 227882 CDS NP_823194.1 29828560 1210334 complement(2460041..2460988) 1 NC_003155.4 uricase 2460988 pucL 1210334 pucL Streptomyces avermitilis MA-4680 uricase NP_823194.1 2460041 R 227882 CDS NP_823195.1 29828561 1213460 complement(2460995..2461402) 1 NC_003155.4 PF00576: Transthyretin precursor (formerly prealbumin); hypothetical protein 2461402 1213460 SAV_2019 Streptomyces avermitilis MA-4680 hypothetical protein NP_823195.1 2460995 R 227882 CDS NP_823196.1 29828562 1213461 complement(2461399..2461917) 1 NC_003155.4 putative OHCU decarboxylase 2461917 1213461 SAV_2020 Streptomyces avermitilis MA-4680 putative OHCU decarboxylase NP_823196.1 2461399 R 227882 CDS NP_823197.1 29828563 1213462 complement(2462114..2462482) 1 NC_003155.4 DNA-binding protein 2462482 1213462 SAV_2021 Streptomyces avermitilis MA-4680 DNA-binding protein NP_823197.1 2462114 R 227882 CDS NP_823198.1 29828564 1213463 complement(2462479..2462730) 1 NC_003155.4 hypothetical protein 2462730 1213463 SAV_2022 Streptomyces avermitilis MA-4680 hypothetical protein NP_823198.1 2462479 R 227882 CDS NP_823199.1 29828565 1213464 2463053..2464564 1 NC_003155.4 hypothetical protein 2464564 1213464 SAV_2023 Streptomyces avermitilis MA-4680 hypothetical protein NP_823199.1 2463053 D 227882 CDS NP_823200.1 29828566 1213465 2464761..2465618 1 NC_003155.4 hydroxypyruvate isomerase 2465618 gip 1213465 gip Streptomyces avermitilis MA-4680 hydroxypyruvate isomerase NP_823200.1 2464761 D 227882 CDS NP_823201.1 29828567 1213466 2465738..2466655 1 NC_003155.4 PF03446: NAD binding domain of 6-phosphogluconate dehydrogenase; 2-hydroxy-3-oxopropionate reductase 2466655 garR 1213466 garR Streptomyces avermitilis MA-4680 2-hydroxy-3-oxopropionate reductase NP_823201.1 2465738 D 227882 CDS NP_823202.1 29828568 1210335 2466817..2468274 1 NC_003155.4 catalase 2468274 katA3 1210335 katA3 Streptomyces avermitilis MA-4680 catalase NP_823202.1 2466817 D 227882 CDS NP_823203.1 29828569 1213467 2468588..2468824 1 NC_003155.4 hypothetical protein 2468824 1213467 SAV_2027 Streptomyces avermitilis MA-4680 hypothetical protein NP_823203.1 2468588 D 227882 CDS NP_823204.1 29828570 1213468 complement(2469196..2470980) 1 NC_003155.4 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; glyoxylate carboligase 2470980 gcl 1213468 gcl Streptomyces avermitilis MA-4680 glyoxylate carboligase NP_823204.1 2469196 R 227882 CDS NP_823205.1 29828571 1213469 2471145..2472263 1 NC_003155.4 hypothetical protein 2472263 1213469 SAV_2029 Streptomyces avermitilis MA-4680 hypothetical protein NP_823205.1 2471145 D 227882 CDS NP_823206.1 29828572 1213470 complement(2472283..2473905) 1 NC_003155.4 activates fatty acids by binding to coenzyme A; AMP-binding domain protein 2473905 1213470 SAV_2030 Streptomyces avermitilis MA-4680 AMP-binding domain protein NP_823206.1 2472283 R 227882 CDS NP_823207.1 29828573 1210336 complement(2473902..2475581) 1 NC_003155.4 acetyl-CoA synthetase 2475581 acsA4 1210336 acsA4 Streptomyces avermitilis MA-4680 acetyl-CoA synthetase NP_823207.1 2473902 R 227882 CDS NP_823208.1 29828574 1213471 2475684..2476523 1 NC_003155.4 LuxR family transcriptional regulator 2476523 1213471 SAV_2032 Streptomyces avermitilis MA-4680 LuxR family transcriptional regulator NP_823208.1 2475684 D 227882 CDS NP_823209.1 29828575 1213472 2476757..2479567 1 NC_003155.4 LuxR family transcriptional regulator 2479567 1213472 SAV_2033 Streptomyces avermitilis MA-4680 LuxR family transcriptional regulator NP_823209.1 2476757 D 227882 CDS NP_823210.1 29828576 1213473 2480500..2481291 1 NC_003155.4 PF00089: Trypsin; trypsin-like protease 2481291 1213473 SAV_2034 Streptomyces avermitilis MA-4680 trypsin-like protease NP_823210.1 2480500 D 227882 CDS NP_823211.1 29828577 1213474 complement(2481442..2482710) 1 NC_003155.4 hypothetical protein 2482710 1213474 SAV_2035 Streptomyces avermitilis MA-4680 hypothetical protein NP_823211.1 2481442 R 227882 CDS NP_823212.1 29828578 1213475 2482828..2483988 1 NC_003155.4 metal-transport protein 2483988 1213475 SAV_2036 Streptomyces avermitilis MA-4680 metal-transport protein NP_823212.1 2482828 D 227882 CDS NP_823213.1 29828579 1213476 complement(2484187..2484477) 1 NC_003155.4 hypothetical protein 2484477 1213476 SAV_2037 Streptomyces avermitilis MA-4680 hypothetical protein NP_823213.1 2484187 R 227882 CDS NP_823214.1 29828580 1213477 complement(2484587..2484862) 1 NC_003155.4 hypothetical protein 2484862 1213477 SAV_2038 Streptomyces avermitilis MA-4680 hypothetical protein NP_823214.1 2484587 R 227882 CDS NP_823215.1 29828581 1210337 2485130..2486941 1 NC_003155.4 methylmalonyl-CoA mutase subunit beta 2486941 mcmB 1210337 mcmB Streptomyces avermitilis MA-4680 methylmalonyl-CoA mutase subunit beta NP_823215.1 2485130 D 227882 CDS NP_823216.1 29828582 1210338 2486941..2489115 1 NC_003155.4 MDM; functions in conversion of succinate to propionate; methylmalonyl-CoA mutase 2489115 meaA2 1210338 meaA2 Streptomyces avermitilis MA-4680 methylmalonyl-CoA mutase NP_823216.1 2486941 D 227882 CDS NP_823217.1 29828583 1213478 2489130..2490116 1 NC_003155.4 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 2490116 argK1 1213478 argK1 Streptomyces avermitilis MA-4680 arginine/ornithine transport system ATPase NP_823217.1 2489130 D 227882 CDS NP_823218.1 29828584 1213479 complement(2490199..2491605) 1 NC_003155.4 DNA-binding protein 2491605 1213479 SAV_2042 Streptomyces avermitilis MA-4680 DNA-binding protein NP_823218.1 2490199 R 227882 CDS NP_823219.1 29828585 1210339 2491982..2493265 1 NC_003155.4 Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates; isocitrate lyase 2493265 aceA 1210339 aceA Streptomyces avermitilis MA-4680 isocitrate lyase NP_823219.1 2491982 D 227882 CDS NP_823220.1 29828586 1213480 2493411..2495003 1 NC_003155.4 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle; malate synthase 2495003 aceB2 1213480 aceB2 Streptomyces avermitilis MA-4680 malate synthase NP_823220.1 2493411 D 227882 CDS NP_823221.1 29828587 1210340 2495000..2495869 1 NC_003155.4 converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; 3-hydroxybutyryl-CoA dehydrogenase 2495869 fadC2 1210340 fadC2 Streptomyces avermitilis MA-4680 3-hydroxybutyryl-CoA dehydrogenase NP_823221.1 2495000 D 227882 CDS NP_823222.1 29828588 1210341 2496389..2498707 1 NC_003155.4 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase 2498707 metE 1210341 metE Streptomyces avermitilis MA-4680 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase NP_823222.1 2496389 D 227882 CDS NP_823223.1 29828589 1213481 2498826..2499458 1 NC_003155.4 PF00300: Phosphoglycerate mutase family; hypothetical protein 2499458 1213481 SAV_2047 Streptomyces avermitilis MA-4680 hypothetical protein NP_823223.1 2498826 D 227882 CDS NP_823224.1 29828590 1213482 complement(2499563..2499997) 1 NC_003155.4 hypothetical protein 2499997 1213482 SAV_2048 Streptomyces avermitilis MA-4680 hypothetical protein NP_823224.1 2499563 R 227882 CDS NP_823225.1 29828591 1213483 complement(2500177..2500935) 1 NC_003155.4 hypothetical protein 2500935 1213483 SAV_2049 Streptomyces avermitilis MA-4680 hypothetical protein NP_823225.1 2500177 R 227882 CDS NP_823226.1 29828592 1213484 complement(2500955..2501176) 1 NC_003155.4 hypothetical protein 2501176 1213484 SAV_2050 Streptomyces avermitilis MA-4680 hypothetical protein NP_823226.1 2500955 R 227882 CDS NP_823227.1 29828593 1213485 complement(2501322..2501942) 1 NC_003155.4 PF00144: Beta-lactamase; hydrolase 2501942 1213485 SAV_2051 Streptomyces avermitilis MA-4680 hydrolase NP_823227.1 2501322 R 227882 CDS NP_823228.1 29828594 1213486 2502254..2503138 1 NC_003155.4 PF04138: GtrA-like protein; hypothetical protein 2503138 1213486 SAV_2052 Streptomyces avermitilis MA-4680 hypothetical protein NP_823228.1 2502254 D 227882 CDS NP_823229.1 29828595 1210342 2503388..2503894 1 NC_003155.4 methylated-DNA--protein-cysteine S-methyltransferase 2503894 ogt2 1210342 ogt2 Streptomyces avermitilis MA-4680 methylated-DNA--protein-cysteine S-methyltransferase NP_823229.1 2503388 D 227882 CDS NP_823230.1 29828596 1213487 2504022..2504753 1 NC_003155.4 hypothetical protein 2504753 1213487 SAV_2054 Streptomyces avermitilis MA-4680 hypothetical protein NP_823230.1 2504022 D 227882 CDS NP_823231.1 29828597 1213488 complement(2504984..2505988) 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 2505988 1213488 SAV_2055 Streptomyces avermitilis MA-4680 dehydrogenase NP_823231.1 2504984 R 227882 CDS NP_823232.1 29828598 1213489 2506218..2506607 1 NC_003155.4 TetR family transcriptional regulator 2506607 1213489 SAV_2056 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_823232.1 2506218 D 227882 CDS NP_823233.1 29828599 1213490 complement(2506932..2507261) 1 NC_003155.4 hypothetical protein 2507261 1213490 SAV_2057 Streptomyces avermitilis MA-4680 hypothetical protein NP_823233.1 2506932 R 227882 CDS NP_823234.1 29828600 1213491 2507392..2508177 1 NC_003155.4 PF03861: ANTAR domain; hypothetical protein 2508177 1213491 SAV_2058 Streptomyces avermitilis MA-4680 hypothetical protein NP_823234.1 2507392 D 227882 CDS NP_823235.1 29828601 1213492 complement(2508252..2509550) 1 NC_003155.4 two-component system sensor kinase 2509550 1213492 SAV_2059 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_823235.1 2508252 R 227882 CDS NP_823236.1 29828602 1213493 2509863..2510627 1 NC_003155.4 deacetylase 2510627 1213493 SAV_2060 Streptomyces avermitilis MA-4680 deacetylase NP_823236.1 2509863 D 227882 CDS NP_823237.1 29828603 1210343 complement(2510664..2511890) 1 NC_003155.4 CYP179A1; cytochrome P450 2511890 cyp9 1210343 cyp9 Streptomyces avermitilis MA-4680 cytochrome P450 NP_823237.1 2510664 R 227882 CDS NP_823238.1 29828604 1213494 complement(2512000..2513007) 1 NC_003155.4 hypothetical protein 2513007 1213494 SAV_2062 Streptomyces avermitilis MA-4680 hypothetical protein NP_823238.1 2512000 R 227882 CDS NP_823239.1 29828605 1213495 2513146..2513595 1 NC_003155.4 PF03364: Streptomyces cyclase/dehydrase; hypothetical protein 2513595 1213495 SAV_2063 Streptomyces avermitilis MA-4680 hypothetical protein NP_823239.1 2513146 D 227882 CDS NP_823240.1 29828606 1213496 2513783..2514493 1 NC_003155.4 methyltransferase 2514493 1213496 SAV_2064 Streptomyces avermitilis MA-4680 methyltransferase NP_823240.1 2513783 D 227882 CDS NP_823241.1 29828607 1213497 complement(2514502..2515653) 1 NC_003155.4 PF02625: XdhC and CoxI family; hypothetical protein 2515653 1213497 SAV_2065 Streptomyces avermitilis MA-4680 hypothetical protein NP_823241.1 2514502 R 227882 CDS NP_823242.1 29828608 1213498 complement(2515726..2517183) 1 NC_003155.4 permease 2517183 1213498 SAV_2066 Streptomyces avermitilis MA-4680 permease NP_823242.1 2515726 R 227882 CDS NP_823243.1 29828609 1210344 complement(2517348..2519729) 1 NC_003155.4 xanthine dehydrogenase 2519729 pucB 1210344 pucB Streptomyces avermitilis MA-4680 xanthine dehydrogenase NP_823243.1 2517348 R 227882 CDS NP_823244.1 29828610 1213499 complement(2519732..2520322) 1 NC_003155.4 PF01799: [2Fe-2S] binding domain; oxidoreductase 2520322 1213499 SAV_2068 Streptomyces avermitilis MA-4680 oxidoreductase NP_823244.1 2519732 R 227882 CDS NP_823245.1 29828611 1213500 complement(2520322..2521221) 1 NC_003155.4 PF00941: FAD binding domain in molybdopterin dehydrogenase; dehydrogenase 2521221 1213500 SAV_2069 Streptomyces avermitilis MA-4680 dehydrogenase NP_823245.1 2520322 R 227882 CDS NP_823246.1 29828612 1213501 2521609..2523282 1 NC_003155.4 regulatory protein 2523282 1213501 SAV_2070 Streptomyces avermitilis MA-4680 regulatory protein NP_823246.1 2521609 D 227882 CDS NP_823247.1 29828613 1213502 2523435..2524208 1 NC_003155.4 hypothetical protein 2524208 1213502 SAV_2071 Streptomyces avermitilis MA-4680 hypothetical protein NP_823247.1 2523435 D 227882 CDS NP_823248.1 29828614 1213503 complement(2524283..2524564) 1 NC_003155.4 hypothetical protein 2524564 1213503 SAV_2072 Streptomyces avermitilis MA-4680 hypothetical protein NP_823248.1 2524283 R 227882 CDS NP_823249.1 29828615 1213504 complement(2524698..2525588) 1 NC_003155.4 GntR family transcriptional regulator 2525588 1213504 SAV_2073 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_823249.1 2524698 R 227882 CDS NP_823250.1 29828616 1213505 2525772..2526599 1 NC_003155.4 hypothetical protein 2526599 1213505 SAV_2074 Streptomyces avermitilis MA-4680 hypothetical protein NP_823250.1 2525772 D 227882 CDS NP_823251.1 29828617 1213506 2526922..2527974 1 NC_003155.4 hypothetical protein 2527974 1213506 SAV_2075 Streptomyces avermitilis MA-4680 hypothetical protein NP_823251.1 2526922 D 227882 CDS NP_823252.1 29828618 1213507 complement(2528041..2528463) 1 NC_003155.4 regulatory protein 2528463 1213507 SAV_2076 Streptomyces avermitilis MA-4680 regulatory protein NP_823252.1 2528041 R 227882 CDS NP_823253.1 29828619 1213508 complement(2529077..2529568) 1 NC_003155.4 hypothetical protein 2529568 1213508 SAV_2077 Streptomyces avermitilis MA-4680 hypothetical protein NP_823253.1 2529077 R 227882 CDS NP_823254.1 29828620 1213509 complement(2529637..2530509) 1 NC_003155.4 hypothetical protein 2530509 1213509 SAV_2078 Streptomyces avermitilis MA-4680 hypothetical protein NP_823254.1 2529637 R 227882 CDS NP_823255.1 29828621 1213510 complement(2530721..2532463) 1 NC_003155.4 catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase 2532463 poxB2 1213510 poxB2 Streptomyces avermitilis MA-4680 pyruvate dehydrogenase NP_823255.1 2530721 R 227882 CDS NP_823256.1 29828622 1213511 complement(2532518..2534542) 1 NC_003155.4 hypothetical protein 2534542 1213511 SAV_2080 Streptomyces avermitilis MA-4680 hypothetical protein NP_823256.1 2532518 R 227882 CDS NP_823257.1 29828623 1213512 2535097..2536080 1 NC_003155.4 LuxR family transcriptional regulator 2536080 1213512 SAV_2081 Streptomyces avermitilis MA-4680 LuxR family transcriptional regulator NP_823257.1 2535097 D 227882 CDS NP_823258.1 29828624 1213513 2536117..2536599 1 NC_003155.4 hypothetical protein 2536599 1213513 SAV_2082 Streptomyces avermitilis MA-4680 hypothetical protein NP_823258.1 2536117 D 227882 CDS NP_823259.1 29828625 1213514 complement(2536749..2538014) 1 NC_003155.4 PF00657: GDSL-like Lipase/Acylhydrolase; protein 2538014 1213514 SAV_2083 Streptomyces avermitilis MA-4680 protein NP_823259.1 2536749 R 227882 CDS NP_823260.1 29828626 1213515 2538106..2538507 1 NC_003155.4 PF01243: Pyridoxamine 5'-phosphate oxidase; hypothetical protein 2538507 1213515 SAV_2084 Streptomyces avermitilis MA-4680 hypothetical protein NP_823260.1 2538106 D 227882 CDS NP_823261.1 29828627 1210345 complement(2538571..2539989) 1 NC_003155.4 PF06029: AlkA N-terminal domain; ADA-like regulatory protein 2539989 alkA2 1210345 alkA2 Streptomyces avermitilis MA-4680 ADA-like regulatory protein NP_823261.1 2538571 R 227882 CDS NP_823262.1 29828628 1213516 complement(2540161..2541288) 1 NC_003155.4 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 2541288 1213516 SAV_2086 Streptomyces avermitilis MA-4680 ribosome-associated GTPase NP_823262.1 2540161 R 227882 CDS NP_823263.1 29828629 1213517 complement(2543124..2544659) 1 NC_003155.4 cellulose-binding protein 2544659 1213517 SAV_2087 Streptomyces avermitilis MA-4680 cellulose-binding protein NP_823263.1 2543124 R 227882 CDS NP_823264.1 29828630 1213518 complement(2545065..2546384) 1 NC_003155.4 PF04055: Radical SAM superfamily; hypothetical protein 2546384 1213518 SAV_2088 Streptomyces avermitilis MA-4680 hypothetical protein NP_823264.1 2545065 R 227882 CDS NP_823265.1 29828631 1213519 complement(2546610..2547617) 1 NC_003155.4 PF02826: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; 2-hydroxyacid dehydrogenase 2547617 1213519 SAV_2089 Streptomyces avermitilis MA-4680 2-hydroxyacid dehydrogenase NP_823265.1 2546610 R 227882 CDS NP_823266.1 29828632 1213520 2547752..2549020 1 NC_003155.4 xylitol oxidase 2549020 1213520 SAV_2090 Streptomyces avermitilis MA-4680 xylitol oxidase NP_823266.1 2547752 D 227882 CDS NP_823267.1 29828633 1213521 2549143..2550417 1 NC_003155.4 repressor for sugar metabolism; transcriptional regulator 2550417 1213521 SAV_2091 Streptomyces avermitilis MA-4680 transcriptional regulator NP_823267.1 2549143 D 227882 CDS NP_823268.1 29828634 1213522 2550619..2551920 1 NC_003155.4 sugar ABC transporter substrate-binding protein 2551920 1213522 SAV_2092 Streptomyces avermitilis MA-4680 sugar ABC transporter substrate-binding protein NP_823268.1 2550619 D 227882 CDS NP_823269.1 29828635 1213523 2551959..2552921 1 NC_003155.4 sugar ABC transporter permeases protein 2552921 1213523 SAV_2093 Streptomyces avermitilis MA-4680 sugar ABC transporter permeases protein NP_823269.1 2551959 D 227882 CDS NP_823270.1 29828636 1213524 2552918..2553808 1 NC_003155.4 sugar ABC transporter permeases protein 2553808 1213524 SAV_2094 Streptomyces avermitilis MA-4680 sugar ABC transporter permeases protein NP_823270.1 2552918 D 227882 CDS NP_823271.1 29828637 1210346 2553836..2556883 1 NC_003155.4 beta-galactosidase 2556883 bga5 1210346 bga5 Streptomyces avermitilis MA-4680 beta-galactosidase NP_823271.1 2553836 D 227882 CDS NP_823272.1 29828638 1213525 2557028..2558104 1 NC_003155.4 beta-1,4-xylanase 2558104 1213525 SAV_2096 Streptomyces avermitilis MA-4680 beta-1,4-xylanase NP_823272.1 2557028 D 227882 CDS NP_823273.1 29828639 1213526 complement(2558196..2560583) 1 NC_003155.4 probably MDR transport; uvrA-like protein 2560583 1213526 SAV_2097 Streptomyces avermitilis MA-4680 uvrA-like protein NP_823273.1 2558196 R 227882 CDS NP_823274.1 29828640 1213527 2560900..2561484 1 NC_003155.4 TetR family transcriptional regulator 2561484 1213527 SAV_2098 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_823274.1 2560900 D 227882 CDS NP_823275.1 29828641 1213528 2561477..2562298 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 2562298 1213528 SAV_2099 Streptomyces avermitilis MA-4680 hydrolase NP_823275.1 2561477 D 227882 CDS NP_823276.1 29828642 1213529 2562322..2563719 1 NC_003155.4 hypothetical protein 2563719 1213529 SAV_2100 Streptomyces avermitilis MA-4680 hypothetical protein NP_823276.1 2562322 D 227882 CDS NP_823277.1 29828643 1213530 2563757..2564527 1 NC_003155.4 hypothetical protein 2564527 1213530 SAV_2101 Streptomyces avermitilis MA-4680 hypothetical protein NP_823277.1 2563757 D 227882 CDS NP_823278.1 29828644 1213531 complement(2564514..2564933) 1 NC_003155.4 PF00293: NUDIX domain; hypothetical protein 2564933 1213531 SAV_2102 Streptomyces avermitilis MA-4680 hypothetical protein NP_823278.1 2564514 R 227882 CDS NP_823279.1 29828645 1213532 complement(2565010..2565795) 1 NC_003155.4 hypothetical protein 2565795 1213532 SAV_2103 Streptomyces avermitilis MA-4680 hypothetical protein NP_823279.1 2565010 R 227882 CDS NP_823280.1 29828646 1213533 complement(2565792..2566313) 1 NC_003155.4 hypothetical protein 2566313 1213533 SAV_2104 Streptomyces avermitilis MA-4680 hypothetical protein NP_823280.1 2565792 R 227882 CDS NP_823281.1 29828647 1213534 2566572..2567558 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; epoxide hydrolase 2567558 ephB 1213534 ephB Streptomyces avermitilis MA-4680 epoxide hydrolase NP_823281.1 2566572 D 227882 CDS NP_823282.1 29828648 1213535 complement(2567544..2569253) 1 NC_003155.4 hypothetical protein 2569253 1213535 SAV_2106 Streptomyces avermitilis MA-4680 hypothetical protein NP_823282.1 2567544 R 227882 CDS NP_823283.1 29828649 1213536 complement(2569356..2570378) 1 NC_003155.4 PF00657: GDSL-like Lipase/Acylhydrolase; hypothetical protein 2570378 1213536 SAV_2107 Streptomyces avermitilis MA-4680 hypothetical protein NP_823283.1 2569356 R 227882 CDS NP_823284.1 29828650 1213537 2570591..2572267 1 NC_003155.4 rhamnogalacturonase B precursor 2572267 1213537 SAV_2108 Streptomyces avermitilis MA-4680 rhamnogalacturonase B precursor NP_823284.1 2570591 D 227882 CDS NP_823285.1 29828651 1213538 complement(2572280..2573674) 1 NC_003155.4 beta-xylosidase 2573674 1213538 SAV_2109 Streptomyces avermitilis MA-4680 beta-xylosidase NP_823285.1 2572280 R 227882 CDS NP_823286.1 29828652 1213539 2574066..2574395 1 NC_003155.4 hypothetical protein 2574395 1213539 SAV_2110 Streptomyces avermitilis MA-4680 hypothetical protein NP_823286.1 2574066 D 227882 CDS NP_823287.1 29828653 1213540 2574586..2575527 1 NC_003155.4 converts homocysteine and S-adenosyl-methionine to methionine and S-adenosyl-homocysteine or S-methyl-methionine and homocysteine to two methionines; homocysteine methyltransferase 2575527 mmuM 1213540 mmuM Streptomyces avermitilis MA-4680 homocysteine methyltransferase NP_823287.1 2574586 D 227882 CDS NP_823288.1 29828654 1213541 complement(2575584..2576834) 1 NC_003155.4 PF03747: ADP-ribosylglycohydrolase; hydrolase 2576834 1213541 SAV_2112 Streptomyces avermitilis MA-4680 hydrolase NP_823288.1 2575584 R 227882 CDS NP_823289.1 29828655 1213542 complement(2577155..2578756) 1 NC_003155.4 carboxylesterase 2578756 1213542 SAV_2113 Streptomyces avermitilis MA-4680 carboxylesterase NP_823289.1 2577155 R 227882 CDS NP_823290.1 29828656 1213543 2579136..2580185 1 NC_003155.4 LacI family transcriptional regulator 2580185 1213543 SAV_2114 Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_823290.1 2579136 D 227882 CDS NP_823291.1 29828657 1213544 2580182..2582632 1 NC_003155.4 hypothetical protein 2582632 1213544 SAV_2115 Streptomyces avermitilis MA-4680 hypothetical protein NP_823291.1 2580182 D 227882 CDS NP_823292.1 29828658 1213545 complement(2582629..2583333) 1 NC_003155.4 glycosyl hydrolase 2583333 1213545 SAV_2116 Streptomyces avermitilis MA-4680 glycosyl hydrolase NP_823292.1 2582629 R 227882 CDS NP_823293.1 29828659 1213546 complement(2583441..2584100) 1 NC_003155.4 hypothetical protein 2584100 1213546 SAV_2117 Streptomyces avermitilis MA-4680 hypothetical protein NP_823293.1 2583441 R 227882 CDS NP_823294.1 29828660 1213547 2584256..2584654 1 NC_003155.4 quinone binding protein 2584654 1213547 SAV_2118 Streptomyces avermitilis MA-4680 quinone binding protein NP_823294.1 2584256 D 227882 CDS NP_823295.1 29828661 1213548 complement(2584640..2585353) 1 NC_003155.4 AraC family transcription regulator 2585353 1213548 SAV_2119 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_823295.1 2584640 R 227882 CDS NP_823296.1 29828662 1213549 complement(2585462..2586424) 1 NC_003155.4 AraC family transcription regulator 2586424 1213549 SAV_2120 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_823296.1 2585462 R 227882 CDS NP_823297.1 29828663 1213550 2586505..2587338 1 NC_003155.4 PF01113: Dihydrodipicolinate reductase, N-terminus; hypothetical protein 2587338 1213550 SAV_2121 Streptomyces avermitilis MA-4680 hypothetical protein NP_823297.1 2586505 D 227882 CDS NP_823298.1 29828664 1213551 complement(2587406..2588443) 1 NC_003155.4 PF03631: Ribonuclease BN-like family; ribonuclease BN-like family integral membrane protein 2588443 1213551 SAV_2122 Streptomyces avermitilis MA-4680 ribonuclease BN-like family integral membrane protein NP_823298.1 2587406 R 227882 CDS NP_823299.1 29828665 1210347 2588694..2590343 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 2590343 fadE23 1210347 fadE23 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_823299.1 2588694 D 227882 CDS NP_823300.1 29828666 1213552 2590650..2591975 1 NC_003155.4 regulatory protein 2591975 1213552 SAV_2124 Streptomyces avermitilis MA-4680 regulatory protein NP_823300.1 2590650 D 227882 CDS NP_823301.1 29828667 1213553 2592140..2593543 1 NC_003155.4 protein 2593543 1213553 SAV_2125 Streptomyces avermitilis MA-4680 protein NP_823301.1 2592140 D 227882 CDS NP_823302.1 29828668 1210348 2593623..2594195 1 NC_003155.4 acetyltransferase 2594195 cysE 1210348 cysE Streptomyces avermitilis MA-4680 acetyltransferase NP_823302.1 2593623 D 227882 CDS NP_823303.1 29828669 1210349 2594566..2596260 1 NC_003155.4 ferredoxin-nitrite reductase 2596260 nirA 1210349 nirA Streptomyces avermitilis MA-4680 ferredoxin-nitrite reductase NP_823303.1 2594566 D 227882 CDS NP_823304.1 29828670 1213554 2596328..2596507 1 NC_003155.4 hypothetical protein 2596507 1213554 SAV_2128 Streptomyces avermitilis MA-4680 hypothetical protein NP_823304.1 2596328 D 227882 CDS NP_823305.1 29828671 1210350 2596504..2597241 1 NC_003155.4 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 2597241 cysH 1210350 cysH Streptomyces avermitilis MA-4680 phosphoadenosine phosphosulfate reductase NP_823305.1 2596504 D 227882 CDS NP_823306.1 29828672 1210351 2597283..2597819 1 NC_003155.4 adenylylsulfate kinase 2597819 cysC1 1210351 cysC1 Streptomyces avermitilis MA-4680 adenylylsulfate kinase NP_823306.1 2597283 D 227882 CDS NP_823307.1 29828673 1210352 2597816..2598751 1 NC_003155.4 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 2598751 cysD1 1210352 cysD1 Streptomyces avermitilis MA-4680 sulfate adenylyltransferase subunit 2 NP_823307.1 2597816 D 227882 CDS NP_823308.1 29828674 1210353 2598754..2600217 1 NC_003155.4 frameshift; sulfate adenylyltransferase large subunit 2600217 cysN1 1210353 cysN1 Streptomyces avermitilis MA-4680 sulfate adenylyltransferase large subunit NP_823308.1 2598754 D 227882 CDS NP_823309.1 29828675 3238944 2599904..2600110 1 NC_003155.4 frameshift; sulfate adenylyltransferase subunit 1 2600110 3238944 SAV_2133 Streptomyces avermitilis MA-4680 sulfate adenylyltransferase subunit 1 NP_823309.1 2599904 D 227882 CDS NP_823310.1 29828676 1213555 2600310..2601458 1 NC_003155.4 sulfate ABC transporter substrate-binding protein 2601458 1213555 SAV_2134 Streptomyces avermitilis MA-4680 sulfate ABC transporter substrate-binding protein NP_823310.1 2600310 D 227882 CDS NP_823311.1 29828677 1213556 2601471..2602283 1 NC_003155.4 ABC transporter ATP-binding protein 2602283 1213556 SAV_2135 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_823311.1 2601471 D 227882 CDS NP_823312.1 29828678 1213557 2602270..2603181 1 NC_003155.4 ABC transporter permease 2603181 1213557 SAV_2136 Streptomyces avermitilis MA-4680 ABC transporter permease NP_823312.1 2602270 D 227882 CDS NP_823313.1 29828679 1213558 2603189..2603926 1 NC_003155.4 PF01903: CbiX; hypothetical protein 2603926 1213558 SAV_2137 Streptomyces avermitilis MA-4680 hypothetical protein NP_823313.1 2603189 D 227882 CDS NP_823314.1 29828680 1213559 complement(2603984..2604580) 1 NC_003155.4 hypothetical protein 2604580 1213559 SAV_2138 Streptomyces avermitilis MA-4680 hypothetical protein NP_823314.1 2603984 R 227882 CDS NP_823315.1 29828681 1213560 2604877..2605152 1 NC_003155.4 hypothetical protein 2605152 1213560 SAV_2139 Streptomyces avermitilis MA-4680 hypothetical protein NP_823315.1 2604877 D 227882 CDS NP_823316.1 29828682 1213561 complement(2605221..2605766) 1 NC_003155.4 hypothetical protein 2605766 1213561 SAV_2140 Streptomyces avermitilis MA-4680 hypothetical protein NP_823316.1 2605221 R 227882 CDS NP_823317.1 29828683 1213562 2606063..2608336 1 NC_003155.4 PF03176: MMPL family; integral membrane protein 2608336 1213562 SAV_2141 Streptomyces avermitilis MA-4680 integral membrane protein NP_823317.1 2606063 D 227882 CDS NP_823318.1 29828684 1213563 complement(2608407..2609378) 1 NC_003155.4 phosphatidylglycerophosphate synthase 2609378 1213563 SAV_2142 Streptomyces avermitilis MA-4680 phosphatidylglycerophosphate synthase NP_823318.1 2608407 R 227882 CDS NP_823319.1 29828685 1213564 complement(2609665..2610945) 1 NC_003155.4 ABC transporter substrate-binding protein 2610945 1213564 SAV_2143 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_823319.1 2609665 R 227882 CDS NP_823320.1 29828686 1213565 complement(2610945..2611778) 1 NC_003155.4 ABC transporter permease 2611778 1213565 SAV_2144 Streptomyces avermitilis MA-4680 ABC transporter permease NP_823320.1 2610945 R 227882 CDS NP_823321.1 29828687 1213566 complement(2611775..2612713) 1 NC_003155.4 ABC transporter permease 2612713 1213566 SAV_2145 Streptomyces avermitilis MA-4680 ABC transporter permease NP_823321.1 2611775 R 227882 CDS NP_823322.1 29828688 1213567 2612960..2613823 1 NC_003155.4 PF01636: Phosphotransferase enzyme family; hypothetical protein 2613823 1213567 SAV_2146 Streptomyces avermitilis MA-4680 hypothetical protein NP_823322.1 2612960 D 227882 CDS NP_823323.1 29828689 1210354 complement(2613862..2614584) 1 NC_003155.4 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 2614584 dnaQ3 1210354 dnaQ3 Streptomyces avermitilis MA-4680 DNA polymerase III subunit epsilon NP_823323.1 2613862 R 227882 CDS NP_823324.1 29828690 1213568 complement(2614725..2616017) 1 NC_003155.4 hypothetical protein 2616017 1213568 SAV_2148 Streptomyces avermitilis MA-4680 hypothetical protein NP_823324.1 2614725 R 227882 CDS NP_823325.1 29828691 1213569 complement(2616079..2617398) 1 NC_003155.4 copper amine oxidase 2617398 1213569 SAV_2149 Streptomyces avermitilis MA-4680 copper amine oxidase NP_823325.1 2616079 R 227882 CDS NP_823326.1 29828692 1213570 complement(2617549..2618409) 1 NC_003155.4 hypothetical protein 2618409 1213570 SAV_2150 Streptomyces avermitilis MA-4680 hypothetical protein NP_823326.1 2617549 R 227882 CDS NP_823327.1 29828693 1213571 2618580..2620688 1 NC_003155.4 glycogen debranching enzyme 2620688 1213571 SAV_2151 Streptomyces avermitilis MA-4680 glycogen debranching enzyme NP_823327.1 2618580 D 227882 CDS NP_823328.1 29828694 1210355 2621126..2623513 1 NC_003155.4 alpha-amylase 2623513 amyA1 1210355 amyA1 Streptomyces avermitilis MA-4680 alpha-amylase NP_823328.1 2621126 D 227882 CDS NP_823329.1 29828695 1213572 complement(2623527..2624516) 1 NC_003155.4 LysR family transcriptional regulator 2624516 1213572 SAV_2153 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_823329.1 2623527 R 227882 CDS NP_823330.1 29828696 1210356 2624596..2626032 1 NC_003155.4 dihydrolipoamide dehydrogenase 2626032 lpdA2 1210356 lpdA2 Streptomyces avermitilis MA-4680 dihydrolipoamide dehydrogenase NP_823330.1 2624596 D 227882 CDS NP_823331.1 29828697 1213573 2626186..2627436 1 NC_003155.4 PF02826: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; 3-hydroxyacyl-CoA dehydrogenase 2627436 1213573 SAV_2155 Streptomyces avermitilis MA-4680 3-hydroxyacyl-CoA dehydrogenase NP_823331.1 2626186 D 227882 CDS NP_823332.1 29828698 1210357 complement(2627476..2627916) 1 NC_003155.4 PF00720: Subtilisin inhibitor-like; subtilisin inhibitor 2627916 sti1 1210357 sti1 Streptomyces avermitilis MA-4680 subtilisin inhibitor NP_823332.1 2627476 R 227882 CDS NP_823333.1 29828699 1213574 complement(2627913..2629322) 1 NC_003155.4 3-hydroxyacyl-CoA dehydrogenase 2629322 1213574 SAV_2157 Streptomyces avermitilis MA-4680 3-hydroxyacyl-CoA dehydrogenase NP_823333.1 2627913 R 227882 CDS NP_823334.1 29828700 1213575 complement(2629485..2630123) 1 NC_003155.4 hypothetical protein 2630123 1213575 SAV_2158 Streptomyces avermitilis MA-4680 hypothetical protein NP_823334.1 2629485 R 227882 CDS NP_823335.1 29828701 1210358 2630209..2631954 1 NC_003155.4 PF00498: FHA domain; alpha-amylase 2631954 amyA2 1210358 amyA2 Streptomyces avermitilis MA-4680 alpha-amylase NP_823335.1 2630209 D 227882 CDS NP_823336.1 29828702 1213576 complement(2632064..2632999) 1 NC_003155.4 transferase 2632999 1213576 SAV_2160 Streptomyces avermitilis MA-4680 transferase NP_823336.1 2632064 R 227882 CDS NP_823337.1 29828703 1213577 complement(2633043..2634188) 1 NC_003155.4 PF00557: metallopeptidase family M24; peptidase 2634188 1213577 SAV_2161 Streptomyces avermitilis MA-4680 peptidase NP_823337.1 2633043 R 227882 CDS NP_823338.1 29828704 1213578 complement(2634707..2635048) 1 NC_003155.4 PF00595: PDZ domain (Also known as DHR or GLGF); hypothetical protein 2635048 1213578 SAV_2162 Streptomyces avermitilis MA-4680 hypothetical protein NP_823338.1 2634707 R 227882 CDS NP_823339.1 29828705 1210359 complement(2635583..2637760) 1 NC_003155.4 geosmin biosynthesis; germacradienol synthase 2637760 geoA 1210359 geoA Streptomyces avermitilis MA-4680 germacradienol synthase NP_823339.1 2635583 R 227882 CDS NP_823340.1 29828706 1210360 2637962..2638741 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 2638741 1210360 SAV_2164 Streptomyces avermitilis MA-4680 hydrolase NP_823340.1 2637962 D 227882 CDS NP_823341.1 29828707 1210361 2638738..2640003 1 NC_003155.4 CYP180A1; cytochrome P450 2640003 1210361 SAV_2165 Streptomyces avermitilis MA-4680 cytochrome P450 NP_823341.1 2638738 D 227882 CDS NP_823342.1 29828708 1213579 complement(2640012..2641226) 1 NC_003155.4 PF01937: Protein of unknown function DUF89; hypothetical protein 2641226 1213579 SAV_2166 Streptomyces avermitilis MA-4680 hypothetical protein NP_823342.1 2640012 R 227882 CDS NP_823343.1 29828709 1213580 complement(2641219..2641800) 1 NC_003155.4 hypothetical protein 2641800 1213580 SAV_2167 Streptomyces avermitilis MA-4680 hypothetical protein NP_823343.1 2641219 R 227882 CDS NP_823344.1 29828710 1213581 2641968..2642903 1 NC_003155.4 PF03067: Chitin binding domain; cellulose-binding protein 2642903 1213581 SAV_2168 Streptomyces avermitilis MA-4680 cellulose-binding protein NP_823344.1 2641968 D 227882 CDS NP_823345.1 29828711 1213582 complement(2643034..2644206) 1 NC_003155.4 hypothetical protein 2644206 1213582 SAV_2169 Streptomyces avermitilis MA-4680 hypothetical protein NP_823345.1 2643034 R 227882 CDS NP_823346.1 29828712 1213583 2644470..2645144 1 NC_003155.4 cholesterol esterase 2645144 1213583 SAV_2170 Streptomyces avermitilis MA-4680 cholesterol esterase NP_823346.1 2644470 D 227882 CDS NP_823347.1 29828713 1213584 2645144..2645563 1 NC_003155.4 hypothetical protein 2645563 1213584 SAV_2171 Streptomyces avermitilis MA-4680 hypothetical protein NP_823347.1 2645144 D 227882 CDS NP_823348.1 29828714 1213585 complement(2645871..2646671) 1 NC_003155.4 SgaA homolog, PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hydroxylase 2646671 1213585 SAV_2172 Streptomyces avermitilis MA-4680 hydroxylase NP_823348.1 2645871 R 227882 CDS NP_823349.1 29828715 1213586 complement(2646843..2647331) 1 NC_003155.4 hypothetical protein 2647331 1213586 SAV_2173 Streptomyces avermitilis MA-4680 hypothetical protein NP_823349.1 2646843 R 227882 CDS NP_823350.1 29828716 1213587 complement(2647309..2648019) 1 NC_003155.4 PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; hypothetical protein 2648019 1213587 SAV_2174 Streptomyces avermitilis MA-4680 hypothetical protein NP_823350.1 2647309 R 227882 CDS NP_823351.1 29828717 1213588 2648187..2649062 1 NC_003155.4 DNA-binding protein 2649062 1213588 SAV_2175 Streptomyces avermitilis MA-4680 DNA-binding protein NP_823351.1 2648187 D 227882 CDS NP_823352.1 29828718 1210362 2649063..2649314 1 NC_003155.4 regulatory protein, PF04149: Domain of unknown function (DUF397); AbaA-like protein 2649314 abaA1 1210362 abaA1 Streptomyces avermitilis MA-4680 AbaA-like protein NP_823352.1 2649063 D 227882 CDS NP_823353.1 29828719 1213589 2649403..2650233 1 NC_003155.4 PF04672: Protein of unknown function (DUF574); hypothetical protein 2650233 1213589 SAV_2177 Streptomyces avermitilis MA-4680 hypothetical protein NP_823353.1 2649403 D 227882 CDS NP_823354.1 29828720 1213590 complement(2650339..2651343) 1 NC_003155.4 ABC transporter substrate-binding protein 2651343 1213590 SAV_2178 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_823354.1 2650339 R 227882 CDS NP_823355.1 29828721 1210363 2651518..2654274 1 NC_003155.4 multi-component regulatory system-4; sensor-like histidine kinase 2654274 cvnA4 1210363 cvnA4 Streptomyces avermitilis MA-4680 sensor-like histidine kinase NP_823355.1 2651518 D 227882 CDS NP_823356.1 29828722 1210364 2654271..2654747 1 NC_003155.4 multi-component regulatory system-4, PF03259: Roadblock/LC7 domain; hypothetical protein 2654747 cvnB4 1210364 cvnB4 Streptomyces avermitilis MA-4680 hypothetical protein NP_823356.1 2654271 D 227882 CDS NP_823357.1 29828723 1210365 2654781..2655221 1 NC_003155.4 multi-component regulatory system-4, PF05331: Protein of unknown function (DUF742); hypothetical protein 2655221 cvnC4 1210365 cvnC4 Streptomyces avermitilis MA-4680 hypothetical protein NP_823357.1 2654781 D 227882 CDS NP_823358.1 29828724 1210366 2655208..2655783 1 NC_003155.4 multi-component regulatory system-4; ATP/GTP-binding protein 2655783 cvnD4 1210366 cvnD4 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_823358.1 2655208 D 227882 CDS NP_823359.1 29828725 1213591 complement(2655841..2656509) 1 NC_003155.4 ABC transporter permease 2656509 1213591 SAV_2183 Streptomyces avermitilis MA-4680 ABC transporter permease NP_823359.1 2655841 R 227882 CDS NP_823360.1 29828726 1213592 complement(2656506..2657228) 1 NC_003155.4 ABC transporter permease 2657228 1213592 SAV_2184 Streptomyces avermitilis MA-4680 ABC transporter permease NP_823360.1 2656506 R 227882 CDS NP_823361.1 29828727 1213593 complement(2657225..2658352) 1 NC_003155.4 ABC transporter ATP-binding protein 2658352 1213593 SAV_2185 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_823361.1 2657225 R 227882 CDS NP_823362.1 29828728 1210367 complement(2658461..2660437) 1 NC_003155.4 alpha-galactosidase 2660437 agaA2 1210367 agaA2 Streptomyces avermitilis MA-4680 alpha-galactosidase NP_823362.1 2658461 R 227882 CDS NP_823363.1 29828729 1213594 2660768..2661793 1 NC_003155.4 ABC transporter substrate-binding protein 2661793 1213594 SAV_2187 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_823363.1 2660768 D 227882 CDS NP_823364.1 29828730 1210368 2662022..2664511 1 NC_003155.4 multi-component regulatory system-5; sensor-like histidine kinase 2664511 cvnA5 1210368 cvnA5 Streptomyces avermitilis MA-4680 sensor-like histidine kinase NP_823364.1 2662022 D 227882 CDS NP_823365.1 29828731 1210369 2664523..2664954 1 NC_003155.4 multi-component regulatory system-5, PF03259: Roadblock/LC7 domain; hypothetical protein 2664954 cvnB5 1210369 cvnB5 Streptomyces avermitilis MA-4680 hypothetical protein NP_823365.1 2664523 D 227882 CDS NP_823366.1 29828732 1210370 2664956..2665312 1 NC_003155.4 multi-component regulatory system-5, PF05331: Protein of unknown function (DUF742); hypothetical protein 2665312 cvnC5 1210370 cvnC5 Streptomyces avermitilis MA-4680 hypothetical protein NP_823366.1 2664956 D 227882 CDS NP_823367.1 29828733 1210371 2665299..2665883 1 NC_003155.4 multi-component regulatory system-5; ATP/GTP-binding protein 2665883 cvnD5 1210371 cvnD5 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_823367.1 2665299 D 227882 CDS NP_823368.1 29828734 1213595 complement(2665941..2666678) 1 NC_003155.4 thiamine biosynthesis lipoprotein precursor 2666678 apbE1 1213595 apbE1 Streptomyces avermitilis MA-4680 thiamine biosynthesis lipoprotein precursor NP_823368.1 2665941 R 227882 CDS NP_823369.1 29828735 1213596 complement(2666680..2667099) 1 NC_003155.4 PF04205: FMN-binding domain; hypothetical protein 2667099 1213596 SAV_2193 Streptomyces avermitilis MA-4680 hypothetical protein NP_823369.1 2666680 R 227882 CDS NP_823370.1 29828736 1213597 complement(2667119..2668537) 1 NC_003155.4 PF01794: Ferric reductase like transmembrane component; oxidoreductase 2668537 1213597 SAV_2194 Streptomyces avermitilis MA-4680 oxidoreductase NP_823370.1 2667119 R 227882 CDS NP_823371.1 29828737 1213598 2668563..2669351 1 NC_003155.4 two-component system response regulator 2669351 1213598 SAV_2195 Streptomyces avermitilis MA-4680 two-component system response regulator NP_823371.1 2668563 D 227882 CDS NP_823372.1 29828738 1213599 2669348..2670784 1 NC_003155.4 two-component system sensor kinase 2670784 1213599 SAV_2196 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_823372.1 2669348 D 227882 CDS NP_823373.1 29828739 1213600 complement(2670814..2672757) 1 NC_003155.4 PF00733: Asparagine synthase; hypothetical protein 2672757 1213600 SAV_2197 Streptomyces avermitilis MA-4680 hypothetical protein NP_823373.1 2670814 R 227882 CDS NP_823374.1 29828740 1213601 complement(2672633..2673259) 1 NC_003155.4 hypothetical protein 2673259 1213601 SAV_2198 Streptomyces avermitilis MA-4680 hypothetical protein NP_823374.1 2672633 R 227882 CDS NP_823375.1 29828741 1213602 complement(2673659..2677531) 1 NC_003155.4 PF00004: ATPase family associated with various cellular activities (AAA); hypothetical protein 2677531 1213602 SAV_2199 Streptomyces avermitilis MA-4680 hypothetical protein NP_823375.1 2673659 R 227882 CDS NP_823376.1 29828742 1213603 2677693..2677977 1 NC_003155.4 hypothetical protein 2677977 1213603 SAV_2200 Streptomyces avermitilis MA-4680 hypothetical protein NP_823376.1 2677693 D 227882 CDS NP_823377.1 29828743 1213604 2677988..2678917 1 NC_003155.4 hypothetical protein 2678917 1213604 SAV_2201 Streptomyces avermitilis MA-4680 hypothetical protein NP_823377.1 2677988 D 227882 CDS NP_823378.1 29828744 1213605 2679054..2682824 1 NC_003155.4 hypothetical protein 2682824 1213605 SAV_2202 Streptomyces avermitilis MA-4680 hypothetical protein NP_823378.1 2679054 D 227882 CDS NP_823379.1 29828745 1213606 2683170..2684009 1 NC_003155.4 PF00702: haloacid dehalogenase-like hydrolase; hydrolase 2684009 1213606 SAV_2203 Streptomyces avermitilis MA-4680 hydrolase NP_823379.1 2683170 D 227882 CDS NP_823380.1 29828746 1213607 complement(2684050..2684457) 1 NC_003155.4 PF01641: SelR domain; oxidoreductase 2684457 1213607 SAV_2204 Streptomyces avermitilis MA-4680 oxidoreductase NP_823380.1 2684050 R 227882 CDS NP_823381.1 29828747 1210372 complement(2684471..2685865) 1 NC_003155.4 UDP-N-acetylmuramoyl-L-alanine ligase 2685865 murC 1210372 murC Streptomyces avermitilis MA-4680 UDP-N-acetylmuramoyl-L-alanine ligase NP_823381.1 2684471 R 227882 CDS NP_823382.1 29828748 1213608 complement(2686042..2686515) 1 NC_003155.4 hypothetical protein 2686515 1213608 SAV_2206 Streptomyces avermitilis MA-4680 hypothetical protein NP_823382.1 2686042 R 227882 CDS NP_823383.1 29828749 1213609 complement(2686713..2687531) 1 NC_003155.4 PF01872: RibD C-terminal domain; hypothetical protein 2687531 1213609 SAV_2208 Streptomyces avermitilis MA-4680 hypothetical protein NP_823383.1 2686713 R 227882 CDS NP_823384.1 29828750 1213610 2687530..2688666 1 NC_003155.4 ATP/GTP-binding protein 2688666 1213610 SAV_2207 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_823384.1 2687530 D 227882 CDS NP_823385.1 29828751 1213611 2688824..2689216 1 NC_003155.4 hypothetical protein 2689216 1213611 SAV_2209 Streptomyces avermitilis MA-4680 hypothetical protein NP_823385.1 2688824 D 227882 CDS NP_823386.1 29828752 1210373 2689365..2689946 1 NC_003155.4 carbonic anhydrase 2689946 cynT1 1210373 cynT1 Streptomyces avermitilis MA-4680 carbonic anhydrase NP_823386.1 2689365 D 227882 CDS NP_823387.1 29828753 1213612 2689943..2691433 1 NC_003155.4 sulfate transporter 2691433 1213612 SAV_2211 Streptomyces avermitilis MA-4680 sulfate transporter NP_823387.1 2689943 D 227882 CDS NP_823388.1 29828754 1213613 2691565..2692521 1 NC_003155.4 PF01145: SPFH domain / Band 7 family; membrane protease subunit stomatin/prohibitin-like protein 2692521 1213613 SAV_2212 Streptomyces avermitilis MA-4680 membrane protease subunit stomatin/prohibitin-like protein NP_823388.1 2691565 D 227882 CDS NP_823389.1 29828755 1213614 2692611..2693993 1 NC_003155.4 PF05787: Bacterial protein of unknown function (DUF839); hypothetical protein 2693993 1213614 SAV_2213 Streptomyces avermitilis MA-4680 hypothetical protein NP_823389.1 2692611 D 227882 CDS NP_823390.1 29828756 1213615 2694231..2695100 1 NC_003155.4 PF01522: Polysaccharide deacetylase; lipoprotein 2695100 1213615 SAV_2214 Streptomyces avermitilis MA-4680 lipoprotein NP_823390.1 2694231 D 227882 CDS NP_823391.1 29828757 1213616 2695154..2695333 1 NC_003155.4 hypothetical protein 2695333 1213616 SAV_2215 Streptomyces avermitilis MA-4680 hypothetical protein NP_823391.1 2695154 D 227882 CDS NP_823392.1 29828758 1213617 2695406..2696179 1 NC_003155.4 PF01981: Domain of unknown function UPF0099; hypothetical protein 2696179 1213617 SAV_2216 Streptomyces avermitilis MA-4680 hypothetical protein NP_823392.1 2695406 D 227882 CDS NP_823393.1 29828759 1213618 2696357..2697145 1 NC_003155.4 protein 2697145 1213618 SAV_2217 Streptomyces avermitilis MA-4680 protein NP_823393.1 2696357 D 227882 CDS NP_823394.1 29828760 1213619 2697334..2698797 1 NC_003155.4 PF05114: Protein of unknown function (DUF692); hypothetical protein 2698797 1213619 SAV_2218 Streptomyces avermitilis MA-4680 hypothetical protein NP_823394.1 2697334 D 227882 CDS NP_823395.1 29828761 1213620 2699175..2699942 1 NC_003155.4 protein 2699942 1213620 SAV_2219 Streptomyces avermitilis MA-4680 protein NP_823395.1 2699175 D 227882 CDS NP_823396.1 29828762 1213621 2700103..2700870 1 NC_003155.4 integral membrane protein 2700870 1213621 SAV_2220 Streptomyces avermitilis MA-4680 integral membrane protein NP_823396.1 2700103 D 227882 CDS NP_823397.1 29828763 1213622 complement(2701084..2701815) 1 NC_003155.4 PF06778: Chlorite dismutase; hypothetical protein 2701815 1213622 SAV_2221 Streptomyces avermitilis MA-4680 hypothetical protein NP_823397.1 2701084 R 227882 CDS NP_823398.1 29828764 1210374 complement(2701820..2702470) 1 NC_003155.4 frameshift; protoporphyrinogen oxidase 2702470 hemY 1210374 hemY Streptomyces avermitilis MA-4680 protoporphyrinogen oxidase NP_823398.1 2701820 R 227882 CDS NP_823399.1 29828765 1213623 complement(2701864..2703288) 1 NC_003155.4 frameshift; protoporphyrinogen oxidase 2703288 1213623 SAV_2223 Streptomyces avermitilis MA-4680 protoporphyrinogen oxidase NP_823399.1 2701864 R 227882 CDS NP_823400.1 29828766 1213624 2703486..2704460 1 NC_003155.4 lipoprotein 2704460 1213624 SAV_2224 Streptomyces avermitilis MA-4680 lipoprotein NP_823400.1 2703486 D 227882 CDS NP_823401.1 29828767 1213625 2704494..2705894 1 NC_003155.4 PF00070: Pyridine nucleotide-disulphide oxidoreductase; flavoprotein oxidoreductase 2705894 1213625 SAV_2225 Streptomyces avermitilis MA-4680 flavoprotein oxidoreductase NP_823401.1 2704494 D 227882 CDS NP_823402.1 29828768 1213626 complement(2705952..2706365) 1 NC_003155.4 hypothetical protein 2706365 1213626 SAV_2226 Streptomyces avermitilis MA-4680 hypothetical protein NP_823402.1 2705952 R 227882 CDS NP_823403.1 29828769 1213627 2706401..2707219 1 NC_003155.4 PF01694: Rhomboid family; hypothetical protein 2707219 1213627 SAV_2227 Streptomyces avermitilis MA-4680 hypothetical protein NP_823403.1 2706401 D 227882 CDS NP_823404.1 29828770 1210375 complement(2707230..2708297) 1 NC_003155.4 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 2708297 hemE 1210375 hemE Streptomyces avermitilis MA-4680 uroporphyrinogen decarboxylase NP_823404.1 2707230 R 227882 CDS NP_823405.1 29828771 1213628 2708486..2709157 1 NC_003155.4 hypothetical protein 2709157 1213628 SAV_2229 Streptomyces avermitilis MA-4680 hypothetical protein NP_823405.1 2708486 D 227882 CDS NP_823406.1 29828772 1213629 2709485..2710147 1 NC_003155.4 two-component system response regulator 2710147 1213629 SAV_2230 Streptomyces avermitilis MA-4680 two-component system response regulator NP_823406.1 2709485 D 227882 CDS NP_823407.1 29828773 1210376 2710371..2711651 1 NC_003155.4 PF01612: 3'-5' exonuclease; ribonuclease D 2711651 rnd 1210376 rnd Streptomyces avermitilis MA-4680 ribonuclease D NP_823407.1 2710371 D 227882 CDS NP_823408.1 29828774 1213630 complement(2711655..2712053) 1 NC_003155.4 hypothetical protein 2712053 1213630 SAV_2232 Streptomyces avermitilis MA-4680 hypothetical protein NP_823408.1 2711655 R 227882 CDS NP_823409.1 29828775 1210377 2712145..2713371 1 NC_003155.4 PF00108: Thiolase, N-terminal domain; 3-ketoacyl-CoA thiolase 2713371 fadA8 1210377 fadA8 Streptomyces avermitilis MA-4680 3-ketoacyl-CoA thiolase NP_823409.1 2712145 D 227882 CDS NP_823410.1 29828776 1210378 2713368..2715494 1 NC_003155.4 similar to glyoxysomal fatty acid beta-oxidation multifunctional protein MFP-a: including enoyl-CoA hydratase; 3-2-trans-enoyl-CoA isomerase; 3-hydroxybutyryl-CoA epimerase; 3-hydroxyacyl-CoA dehydrogenase; fatty acid oxidation complex alpha-subunit 2715494 fadB2 1210378 fadB2 Streptomyces avermitilis MA-4680 fatty acid oxidation complex alpha-subunit NP_823410.1 2713368 D 227882 CDS NP_823411.1 29828777 1210379 complement(2715592..2720106) 1 NC_003155.4 galactosamine-containing minor teichoic acid biosynthesis protein 2720106 ggaB 1210379 ggaB Streptomyces avermitilis MA-4680 galactosamine-containing minor teichoic acid biosynthesis protein NP_823411.1 2715592 R 227882 CDS NP_823412.1 29828778 1213631 complement(2720088..2721308) 1 NC_003155.4 PF01066: CDP-alcohol phosphatidyltransferase; hypothetical protein 2721308 1213631 SAV_2236 Streptomyces avermitilis MA-4680 hypothetical protein NP_823412.1 2720088 R 227882 CDS NP_823413.1 29828779 1213632 complement(2721613..2723190) 1 NC_003155.4 hypothetical protein 2723190 1213632 SAV_2237 Streptomyces avermitilis MA-4680 hypothetical protein NP_823413.1 2721613 R 227882 CDS NP_823414.1 29828780 1213633 complement(2723231..2724472) 1 NC_003155.4 hypothetical protein 2724472 1213633 SAV_2238 Streptomyces avermitilis MA-4680 hypothetical protein NP_823414.1 2723231 R 227882 CDS NP_823415.1 29828781 1210380 complement(2724430..2725416) 1 NC_003155.4 UDP-glucose 4-epimerase 2725416 galE7 1210380 galE7 Streptomyces avermitilis MA-4680 UDP-glucose 4-epimerase NP_823415.1 2724430 R 227882 CDS NP_823416.1 29828782 1213634 2725600..2726709 1 NC_003155.4 transcriptional regulator 2726709 1213634 SAV_2240 Streptomyces avermitilis MA-4680 transcriptional regulator NP_823416.1 2725600 D 227882 CDS NP_823417.1 29828783 1213635 2726824..2727189 1 NC_003155.4 hypothetical protein 2727189 1213635 SAV_2241 Streptomyces avermitilis MA-4680 hypothetical protein NP_823417.1 2726824 D 227882 CDS NP_823418.1 29828784 1213636 complement(2727250..2728743) 1 NC_003155.4 PF02366: Dolichyl-phosphate-mannose-protein mannosyltransferase; hypothetical protein 2728743 1213636 SAV_2242 Streptomyces avermitilis MA-4680 hypothetical protein NP_823418.1 2727250 R 227882 CDS NP_823419.1 29828785 1213637 complement(2728807..2730330) 1 NC_003155.4 PF00324: Amino acid permease; cationic amino acid transporter 2730330 1213637 SAV_2243 Streptomyces avermitilis MA-4680 cationic amino acid transporter NP_823419.1 2728807 R 227882 CDS NP_823420.1 29828786 1210381 complement(2730469..2732397) 1 NC_003155.4 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 2732397 dxs2 1210381 dxs2 Streptomyces avermitilis MA-4680 1-deoxy-D-xylulose-5-phosphate synthase NP_823420.1 2730469 R 227882 CDS NP_823421.1 29828787 1213638 complement(2732614..2733906) 1 NC_003155.4 ABC transporter permease 2733906 1213638 SAV_2245 Streptomyces avermitilis MA-4680 ABC transporter permease NP_823421.1 2732614 R 227882 CDS NP_823422.1 29828788 1213639 complement(2733903..2734691) 1 NC_003155.4 ABC transporter ATP-binding protein 2734691 1213639 SAV_2246 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_823422.1 2733903 R 227882 CDS NP_823423.1 29828789 1213640 complement(2734874..2735983) 1 NC_003155.4 ABC transporter substrate-binding protein 2735983 1213640 SAV_2247 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_823423.1 2734874 R 227882 CDS NP_823424.1 29828790 1213641 complement(2736105..2737304) 1 NC_003155.4 transcriptional regulator 2737304 1213641 SAV_2248 Streptomyces avermitilis MA-4680 transcriptional regulator NP_823424.1 2736105 R 227882 CDS NP_823425.1 29828791 1213642 complement(2737656..2738576) 1 NC_003155.4 ABC transporter permease 2738576 1213642 SAV_2249 Streptomyces avermitilis MA-4680 ABC transporter permease NP_823425.1 2737656 R 227882 CDS NP_823426.1 29828792 1213643 complement(2738576..2739499) 1 NC_003155.4 PF00528: Binding-protein-dependent transport system inner membrane component; ABC transporter permease 2739499 1213643 SAV_2250 Streptomyces avermitilis MA-4680 ABC transporter permease NP_823426.1 2738576 R 227882 CDS NP_823427.1 29828793 1213644 complement(2739559..2741016) 1 NC_003155.4 ABC transporter substrate-binding protein 2741016 1213644 SAV_2251 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_823427.1 2739559 R 227882 CDS NP_823428.1 29828794 1213645 2741507..2745352 1 NC_003155.4 ATP/GTP-binding protein 2745352 1213645 SAV_2252 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_823428.1 2741507 D 227882 CDS NP_823429.1 29828795 1213646 complement(2745431..2748745) 1 NC_003155.4 hypothetical protein 2748745 1213646 SAV_2253 Streptomyces avermitilis MA-4680 hypothetical protein NP_823429.1 2745431 R 227882 CDS NP_823430.1 29828796 1210382 complement(2749073..2750248) 1 NC_003155.4 cellulose binding protein 2750248 celS2 1210382 celS2 Streptomyces avermitilis MA-4680 cellulose binding protein NP_823430.1 2749073 R 227882 CDS NP_823431.1 29828797 1213647 2750352..2750849 1 NC_003155.4 hypothetical protein 2750849 1213647 SAV_2255 Streptomyces avermitilis MA-4680 hypothetical protein NP_823431.1 2750352 D 227882 CDS NP_823432.1 29828798 1213648 complement(2750900..2752438) 1 NC_003155.4 two-component system sensor kinase 2752438 1213648 SAV_2256 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_823432.1 2750900 R 227882 CDS NP_823433.1 29828799 1213649 complement(2752435..2753160) 1 NC_003155.4 two-component system response regulator 2753160 1213649 SAV_2257 Streptomyces avermitilis MA-4680 two-component system response regulator NP_823433.1 2752435 R 227882 CDS NP_823434.1 29828800 1210383 complement(2753293..2756010) 1 NC_003155.4 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 2756010 acnA 1210383 acnA Streptomyces avermitilis MA-4680 aconitate hydratase NP_823434.1 2753293 R 227882 CDS NP_823435.1 29828801 1213650 2756601..2756798 1 NC_003155.4 hypothetical protein 2756798 1213650 SAV_2259 Streptomyces avermitilis MA-4680 hypothetical protein NP_823435.1 2756601 D 227882 CDS NP_823436.1 29828802 1210384 2757079..2758392 1 NC_003155.4 UDP-N-acetylglucosamine transferase 2758392 murA1 1210384 murA1 Streptomyces avermitilis MA-4680 UDP-N-acetylglucosamine transferase NP_823436.1 2757079 D 227882 CDS NP_823437.1 29828803 1213651 complement(2758588..2759262) 1 NC_003155.4 hypothetical protein 2759262 1213651 SAV_2261 Streptomyces avermitilis MA-4680 hypothetical protein NP_823437.1 2758588 R 227882 CDS NP_823438.1 29828804 1210385 complement(2759311..2761302) 1 NC_003155.4 serine/threonine protein kinase 2761302 pkn5 1210385 pkn5 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_823438.1 2759311 R 227882 CDS NP_823439.1 29828805 1213652 complement(2761657..2762247) 1 NC_003155.4 TetR family transcriptional regulator 2762247 1213652 SAV_2263 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_823439.1 2761657 R 227882 CDS NP_823440.1 29828806 1213653 2762407..2763975 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 2763975 1213653 SAV_2264 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_823440.1 2762407 D 227882 CDS NP_823441.1 29828807 1213654 2764008..2764211 1 NC_003155.4 hypothetical protein 2764211 1213654 SAV_2265 Streptomyces avermitilis MA-4680 hypothetical protein NP_823441.1 2764008 D 227882 CDS NP_823442.1 29828808 1213655 complement(2764348..2765037) 1 NC_003155.4 PF00702: haloacid dehalogenase-like hydrolase; hypothetical protein 2765037 1213655 SAV_2266 Streptomyces avermitilis MA-4680 hypothetical protein NP_823442.1 2764348 R 227882 CDS NP_823443.1 29828809 1213656 complement(2765027..2766250) 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; oxidoreductase 2766250 1213656 SAV_2267 Streptomyces avermitilis MA-4680 oxidoreductase NP_823443.1 2765027 R 227882 CDS NP_823444.1 29828810 1213657 2766319..2766939 1 NC_003155.4 similar to gamma-butyrolactone-dependent transcriptional regulator; TetR family transcriptional regulator 2766939 1213657 SAV_2268 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_823444.1 2766319 D 227882 CDS NP_823445.1 29828811 1210386 complement(2766968..2768005) 1 NC_003155.4 homology to BarX, FarX, AfsA, and ScbA: containing A-factor biosynthesis repeat motif; gamma-butyrolactone biosynthesis protein 2768005 avaA 1210386 avaA Streptomyces avermitilis MA-4680 gamma-butyrolactone biosynthesis protein NP_823445.1 2766968 R 227882 CDS NP_823446.1 29828812 1213658 2768197..2768853 1 NC_003155.4 similar to gamma-butyrolactone-dependent transcriptional regulator; TetR family transcriptional regulator 2768853 1213658 SAV_2270 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_823446.1 2768197 D 227882 CDS NP_823447.2 57833859 1213659 complement(2769076..2770635) 1 NC_003155.4 VlmK homolog, PF03972: MmgE/PrpD family; hypothetical protein 2770635 1213659 SAV_2272 Streptomyces avermitilis MA-4680 hypothetical protein NP_823447.2 2769076 R 227882 CDS NP_823449.1 29828815 1213661 complement(2770752..2771120) 1 NC_003155.4 isomerase 2771120 1213661 SAV_2273 Streptomyces avermitilis MA-4680 isomerase NP_823449.1 2770752 R 227882 CDS NP_823450.1 29828816 1213662 complement(2771212..2772171) 1 NC_003155.4 VlmJ homolog, PF00781: Diacylglycerol kinase catalytic domain (presumed); hypothetical protein 2772171 1213662 SAV_2274 Streptomyces avermitilis MA-4680 hypothetical protein NP_823450.1 2771212 R 227882 CDS NP_823451.1 29828817 1213663 complement(2772328..2773797) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 2773797 1213663 SAV_2275 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_823451.1 2772328 R 227882 CDS NP_823452.1 29828818 1210387 complement(2773878..2774897) 1 NC_003155.4 pks3 gene cluster; 3-oxoacyl-ACP synthase III 2774897 fabH7 1210387 fabH7 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP synthase III NP_823452.1 2773878 R 227882 CDS NP_823453.1 29828819 1213664 complement(2775228..2775995) 1 NC_003155.4 pks3 gene cluster; thioesterase 2775995 1213664 SAV_2277 Streptomyces avermitilis MA-4680 thioesterase NP_823453.1 2775228 R 227882 CDS NP_823454.1 29828820 1213665 complement(2776016..2777119) 1 NC_003155.4 pks3 gene cluster, PF00296: Luciferase-like monooxygenase; F420-dependent dehydrogenase 2777119 1213665 SAV_2278 Streptomyces avermitilis MA-4680 F420-dependent dehydrogenase NP_823454.1 2776016 R 227882 CDS NP_823455.1 29828821 1213666 complement(2777158..2778762) 1 NC_003155.4 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 2778762 1213666 SAV_2279 Streptomyces avermitilis MA-4680 long-chain-fatty-acid--CoA ligase NP_823455.1 2777158 R 227882 CDS NP_823456.1 29828822 1213667 complement(2778808..2780709) 1 NC_003155.4 pks3 gene cluster; modular polyketide synthase 2780709 pks3-1 1213667 pks3-1 Streptomyces avermitilis MA-4680 modular polyketide synthase NP_823456.1 2778808 R 227882 CDS NP_823457.1 29828823 1213668 complement(2780706..2784467) 1 NC_003155.4 pks3 gene cluster; modular polyketide synthase 2784467 pks3-2 1213668 pks3-2 Streptomyces avermitilis MA-4680 modular polyketide synthase NP_823457.1 2780706 R 227882 CDS NP_823458.1 29828824 1213669 complement(2784503..2784841) 1 NC_003155.4 pks3 gene cluster; ACP 2784841 pks3-3 1213669 pks3-3 Streptomyces avermitilis MA-4680 ACP NP_823458.1 2784503 R 227882 CDS NP_823459.1 29828825 1213670 2785013..2786644 1 NC_003155.4 PF00171: Aldehyde dehydrogenase family; aldehyde dehydrogenase 2786644 1213670 SAV_2283 Streptomyces avermitilis MA-4680 aldehyde dehydrogenase NP_823459.1 2785013 D 227882 CDS NP_823460.1 29828826 1213671 2786679..2787818 1 NC_003155.4 VlmH homolog; isobutylamine N-hydroxylase 2787818 1213671 SAV_2284 Streptomyces avermitilis MA-4680 isobutylamine N-hydroxylase NP_823460.1 2786679 D 227882 CDS NP_823461.1 29828827 1213672 2787876..2789159 1 NC_003155.4 ornithine aminotransferase 2789159 rocD3 1213672 rocD3 Streptomyces avermitilis MA-4680 ornithine aminotransferase NP_823461.1 2787876 D 227882 CDS NP_823462.1 29828828 1213673 2789162..2789644 1 NC_003155.4 PF03364: Streptomyces cyclase/dehydrase; hypothetical protein 2789644 1213673 SAV_2286 Streptomyces avermitilis MA-4680 hypothetical protein NP_823462.1 2789162 D 227882 CDS NP_823463.1 29828829 1213674 2789666..2790202 1 NC_003155.4 hypothetical protein 2790202 1213674 SAV_2287 Streptomyces avermitilis MA-4680 hypothetical protein NP_823463.1 2789666 D 227882 CDS NP_823464.1 29828830 1213675 2790199..2790753 1 NC_003155.4 PF01613: Flavin reductase like domain; NADPH-flavin oxidoreductase 2790753 1213675 SAV_2288 Streptomyces avermitilis MA-4680 NADPH-flavin oxidoreductase NP_823464.1 2790199 D 227882 CDS NP_823465.1 29828831 1213676 2790750..2791733 1 NC_003155.4 VlmB homolog; hypothetical protein 2791733 1213676 SAV_2289 Streptomyces avermitilis MA-4680 hypothetical protein NP_823465.1 2790750 D 227882 CDS NP_823466.1 29828832 1210388 2791730..2792737 1 NC_003155.4 FabH; beta-ketoacyl-ACP synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-ACP synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase III 2792737 fabH3 1210388 fabH3 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP synthase III NP_823466.1 2791730 D 227882 CDS NP_823467.1 29828833 1210389 2792843..2793073 1 NC_003155.4 PF00550: Phosphopantetheine attachment site; ACP 2793073 fabC3 1210389 fabC3 Streptomyces avermitilis MA-4680 ACP NP_823467.1 2792843 D 227882 CDS NP_823468.1 29828834 1210390 2793073..2794293 1 NC_003155.4 PF00109: Beta-ketoacyl synthase, N-terminal domain; 3-oxoacyl-ACP synthase II 2794293 fabF 1210390 fabF Streptomyces avermitilis MA-4680 3-oxoacyl-ACP synthase II NP_823468.1 2793073 D 227882 CDS NP_823469.1 29828835 1213677 2794444..2795964 1 NC_003155.4 amino acid permease 2795964 1213677 SAV_2293 Streptomyces avermitilis MA-4680 amino acid permease NP_823469.1 2794444 D 227882 CDS NP_823470.1 29828836 1210391 2795948..2797231 1 NC_003155.4 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 2797231 serS2 1210391 serS2 Streptomyces avermitilis MA-4680 seryl-tRNA synthetase NP_823470.1 2795948 D 227882 CDS NP_823471.1 29828837 1210392 complement(2797311..2798093) 1 NC_003155.4 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-ACP reductase 2798093 fabI2 1210392 fabI2 Streptomyces avermitilis MA-4680 enoyl-ACP reductase NP_823471.1 2797311 R 227882 CDS NP_823472.1 29828838 1210393 complement(2798090..2798416) 1 NC_003155.4 ferredoxin 2798416 fdxC 1210393 fdxC Streptomyces avermitilis MA-4680 ferredoxin NP_823472.1 2798090 R 227882 CDS NP_823473.1 29828839 1213678 complement(2798419..2799828) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; sugar transporter 2799828 1213678 SAV_2297 Streptomyces avermitilis MA-4680 sugar transporter NP_823473.1 2798419 R 227882 CDS NP_823474.1 29828840 1210394 complement(2800061..2801158) 1 NC_003155.4 PF00487: Fatty acid desaturase; fatty acid desaturase 2801158 fadS2 1210394 fadS2 Streptomyces avermitilis MA-4680 fatty acid desaturase NP_823474.1 2800061 R 227882 CDS NP_823475.1 29828841 1213679 complement(2801444..2801644) 1 NC_003155.4 hypothetical protein 2801644 1213679 SAV_2299 Streptomyces avermitilis MA-4680 hypothetical protein NP_823475.1 2801444 R 227882 CDS NP_823476.1 29828842 1213680 complement(2801738..2802733) 1 NC_003155.4 VlmA homolog, PF04329: Family of unknown function (DUF470); hypothetical protein 2802733 1213680 SAV_2300 Streptomyces avermitilis MA-4680 hypothetical protein NP_823476.1 2801738 R 227882 CDS NP_823477.1 29828843 1213681 2803964..2804761 1 NC_003155.4 regulatory protein 2804761 1213681 SAV_2301 Streptomyces avermitilis MA-4680 regulatory protein NP_823477.1 2803964 D 227882 CDS NP_823478.1 29828844 1213682 2805029..2805460 1 NC_003155.4 hypothetical protein 2805460 1213682 SAV_2302 Streptomyces avermitilis MA-4680 hypothetical protein NP_823478.1 2805029 D 227882 CDS NP_823479.1 29828845 1210395 2805537..2807081 1 NC_003155.4 PF01039: Carboxyl transferase domain; methylmalonyl-CoA decarboxylase alpha subunit 2807081 mmdA1 1210395 mmdA1 Streptomyces avermitilis MA-4680 methylmalonyl-CoA decarboxylase alpha subunit NP_823479.1 2805537 D 227882 CDS NP_823480.1 29828846 1213683 2807097..2807282 1 NC_003155.4 hypothetical protein 2807282 1213683 SAV_2304 Streptomyces avermitilis MA-4680 hypothetical protein NP_823480.1 2807097 D 227882 CDS NP_823481.1 29828847 1213684 complement(2807844..2808242) 1 NC_003155.4 PF01042: Endoribonuclease L-PSP; hypothetical protein 2808242 1213684 SAV_2305 Streptomyces avermitilis MA-4680 hypothetical protein NP_823481.1 2807844 R 227882 CDS NP_823482.1 29828848 1210396 complement(2808239..2809366) 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 2809366 fadE10 1210396 fadE10 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_823482.1 2808239 R 227882 CDS NP_823483.1 29828849 1213685 2809477..2811261 1 NC_003155.4 PF00501: AMP-binding enzyme; fatty acid:CoA ligase 2811261 1213685 SAV_2307 Streptomyces avermitilis MA-4680 fatty acid:CoA ligase NP_823483.1 2809477 D 227882 CDS NP_823484.1 29828850 1213686 2811277..2812119 1 NC_003155.4 regulator 2812119 1213686 SAV_2308 Streptomyces avermitilis MA-4680 regulator NP_823484.1 2811277 D 227882 CDS NP_823485.1 29828851 1213687 2812203..2813102 1 NC_003155.4 PF00685: Sulfotransferase domain; hypothetical protein 2813102 1213687 SAV_2309 Streptomyces avermitilis MA-4680 hypothetical protein NP_823485.1 2812203 D 227882 CDS NP_823486.1 29828852 1213688 2813099..2813509 1 NC_003155.4 hypothetical protein 2813509 1213688 SAV_2310 Streptomyces avermitilis MA-4680 hypothetical protein NP_823486.1 2813099 D 227882 CDS NP_823487.1 29828853 1210397 2813587..2814753 1 NC_003155.4 UDP-glucose:polyglycerol phosphate glucosyltransferase 2814753 tagE 1210397 tagE Streptomyces avermitilis MA-4680 UDP-glucose:polyglycerol phosphate glucosyltransferase NP_823487.1 2813587 D 227882 CDS NP_823488.1 29828854 1210398 2814750..2815301 1 NC_003155.4 adenylylsulfate kinase 2815301 cysC2 1210398 cysC2 Streptomyces avermitilis MA-4680 adenylylsulfate kinase NP_823488.1 2814750 D 227882 CDS NP_823489.1 29828855 1210399 2815298..2816233 1 NC_003155.4 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 2816233 cysD2 1210399 cysD2 Streptomyces avermitilis MA-4680 sulfate adenylyltransferase subunit 2 NP_823489.1 2815298 D 227882 CDS NP_823490.1 29828856 1210400 2816236..2817456 1 NC_003155.4 sulfate adenylyltransferase large subunit 2817456 cysN2 1210400 cysN2 Streptomyces avermitilis MA-4680 sulfate adenylyltransferase large subunit NP_823490.1 2816236 D 227882 CDS NP_823491.1 29828857 1213689 complement(2817480..2819747) 1 NC_003155.4 catalyzes the conversion of salicylyl-CoA to gentisyl-CoA; salicylyl-CoA 5-hydroxylase 2819747 1213689 SAV_2315 Streptomyces avermitilis MA-4680 salicylyl-CoA 5-hydroxylase NP_823491.1 2817480 R 227882 CDS NP_823492.1 29828858 1210401 complement(2819750..2820577) 1 NC_003155.4 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 2820577 echA7 1210401 echA7 Streptomyces avermitilis MA-4680 enoyl-CoA hydratase NP_823492.1 2819750 R 227882 CDS NP_823493.1 29828859 1213690 2820828..2821328 1 NC_003155.4 PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; regulatory protein 2821328 1213690 SAV_2317 Streptomyces avermitilis MA-4680 regulatory protein NP_823493.1 2820828 D 227882 CDS NP_823494.1 29828860 1213691 complement(2821288..2822730) 1 NC_003155.4 amino acid permease 2822730 1213691 SAV_2318 Streptomyces avermitilis MA-4680 amino acid permease NP_823494.1 2821288 R 227882 CDS NP_823495.1 29828861 1210402 complement(2822927..2823934) 1 NC_003155.4 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase 2823934 argF 1210402 argF Streptomyces avermitilis MA-4680 ornithine carbamoyltransferase NP_823495.1 2822927 R 227882 CDS NP_823496.1 29828862 1210403 complement(2824044..2825273) 1 NC_003155.4 arginine deiminase 2825273 arcA 1210403 arcA Streptomyces avermitilis MA-4680 arginine deiminase NP_823496.1 2824044 R 227882 CDS NP_823497.1 29828863 1213692 2825412..2826434 1 NC_003155.4 PF01145: SPFH domain / Band 7 family; hypothetical protein 2826434 1213692 SAV_2321 Streptomyces avermitilis MA-4680 hypothetical protein NP_823497.1 2825412 D 227882 CDS NP_823498.1 29828864 1213693 2826431..2827324 1 NC_003155.4 PF03459: TOBE domain; hypothetical protein 2827324 1213693 SAV_2322 Streptomyces avermitilis MA-4680 hypothetical protein NP_823498.1 2826431 D 227882 CDS NP_823499.1 29828865 1210404 complement(2827733..2830279) 1 NC_003155.4 PF00149: Calcineurin-like phosphoesterase; serine/threonine protein phosphatase 2830279 prpA1 1210404 prpA1 Streptomyces avermitilis MA-4680 serine/threonine protein phosphatase NP_823499.1 2827733 R 227882 CDS NP_823500.1 29828866 1213694 complement(2830276..2831763) 1 NC_003155.4 hypothetical protein 2831763 1213694 SAV_2324 Streptomyces avermitilis MA-4680 hypothetical protein NP_823500.1 2830276 R 227882 CDS NP_823501.1 29828867 1213695 2831927..2832853 1 NC_003155.4 PF00296: Luciferase-like monooxygenase; monooxygenase 2832853 1213695 SAV_2325 Streptomyces avermitilis MA-4680 monooxygenase NP_823501.1 2831927 D 227882 CDS NP_823502.1 29828868 1213696 complement(2832931..2833392) 1 NC_003155.4 hypothetical protein 2833392 1213696 SAV_2326 Streptomyces avermitilis MA-4680 hypothetical protein NP_823502.1 2832931 R 227882 CDS NP_823503.1 29828869 1213697 complement(2833584..2833916) 1 NC_003155.4 PF03819: MazG nucleotide pyrophosphohydrolase domain; hypothetical protein 2833916 1213697 SAV_2327 Streptomyces avermitilis MA-4680 hypothetical protein NP_823503.1 2833584 R 227882 CDS NP_823504.1 29828870 1213698 complement(2833913..2835130) 1 NC_003155.4 bldA-regulated nucleotide binding protein 2835130 1213698 SAV_2328 Streptomyces avermitilis MA-4680 bldA-regulated nucleotide binding protein NP_823504.1 2833913 R 227882 CDS NP_823505.1 29828871 1213699 complement(2835232..2835636) 1 NC_003155.4 PF04472: Protein of unknown function (DUF552); hypothetical protein 2835636 1213699 SAV_2329 Streptomyces avermitilis MA-4680 hypothetical protein NP_823505.1 2835232 R 227882 CDS NP_823506.1 29828872 1210405 2835881..2839939 1 NC_003155.4 assimilatory nitrate reductase large subunit 2839939 narB 1210405 narB Streptomyces avermitilis MA-4680 assimilatory nitrate reductase large subunit NP_823506.1 2835881 D 227882 CDS NP_823507.1 29828873 1213700 2840065..2841777 1 NC_003155.4 hypothetical protein 2841777 1213700 SAV_2331 Streptomyces avermitilis MA-4680 hypothetical protein NP_823507.1 2840065 D 227882 CDS NP_823508.1 29828874 1213701 complement(2841786..2842133) 1 NC_003155.4 transcription regulator ArsR 2842133 1213701 SAV_2332 Streptomyces avermitilis MA-4680 transcription regulator ArsR NP_823508.1 2841786 R 227882 CDS NP_823509.1 29828875 1213702 2842425..2843558 1 NC_003155.4 high-affinity nickel-transport protein 2843558 nicT2 1213702 nicT2 Streptomyces avermitilis MA-4680 high-affinity nickel-transport protein NP_823509.1 2842425 D 227882 CDS NP_823510.1 29828876 1213703 complement(2843585..2844349) 1 NC_003155.4 hypothetical protein 2844349 1213703 SAV_2334 Streptomyces avermitilis MA-4680 hypothetical protein NP_823510.1 2843585 R 227882 CDS NP_823511.1 29828877 1213704 complement(2844389..2845000) 1 NC_003155.4 hypothetical protein 2845000 1213704 SAV_2335 Streptomyces avermitilis MA-4680 hypothetical protein NP_823511.1 2844389 R 227882 CDS NP_823512.1 29828878 1213705 complement(2845071..2850074) 1 NC_003155.4 regulatory protein 2850074 1213705 SAV_2336 Streptomyces avermitilis MA-4680 regulatory protein NP_823512.1 2845071 R 227882 CDS NP_823513.1 29828879 1213706 complement(2850071..2851015) 1 NC_003155.4 PF07728: ATPase family associated with various cellular activities (AAA); MoxR-like ATPase 2851015 1213706 SAV_2337 Streptomyces avermitilis MA-4680 MoxR-like ATPase NP_823513.1 2850071 R 227882 CDS NP_823514.1 29828880 1213707 complement(2851012..2853117) 1 NC_003155.4 hypothetical protein 2853117 1213707 SAV_2338 Streptomyces avermitilis MA-4680 hypothetical protein NP_823514.1 2851012 R 227882 CDS NP_823515.1 29828881 1213708 complement(2853138..2854208) 1 NC_003155.4 hypothetical protein 2854208 1213708 SAV_2339 Streptomyces avermitilis MA-4680 hypothetical protein NP_823515.1 2853138 R 227882 CDS NP_823516.1 29828882 1213709 2854441..2854833 1 NC_003155.4 substrate-binding protein 2854833 1213709 SAV_2340 Streptomyces avermitilis MA-4680 substrate-binding protein NP_823516.1 2854441 D 227882 CDS NP_823517.1 29828883 1213710 2855062..2855481 1 NC_003155.4 molibdenum binding protein 2855481 1213710 SAV_2341 Streptomyces avermitilis MA-4680 molibdenum binding protein NP_823517.1 2855062 D 227882 CDS NP_823518.1 29828884 1213711 2855649..2856317 1 NC_003155.4 PF00597: DedA family; hypothetical protein 2856317 1213711 SAV_2342 Streptomyces avermitilis MA-4680 hypothetical protein NP_823518.1 2855649 D 227882 CDS NP_823519.1 29828885 1213712 complement(2856344..2857687) 1 NC_003155.4 PF03706: Uncharacterised protein family (UPF0104); hypothetical protein 2857687 1213712 SAV_2343 Streptomyces avermitilis MA-4680 hypothetical protein NP_823519.1 2856344 R 227882 CDS NP_823520.1 29828886 1213713 complement(2857684..2859243) 1 NC_003155.4 hypothetical protein 2859243 1213713 SAV_2344 Streptomyces avermitilis MA-4680 hypothetical protein NP_823520.1 2857684 R 227882 CDS NP_823521.1 29828887 1213714 complement(2859641..2860309) 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 2860309 1213714 SAV_2345 Streptomyces avermitilis MA-4680 dehydrogenase NP_823521.1 2859641 R 227882 CDS NP_823522.1 29828888 1213715 2860718..2861371 1 NC_003155.4 cell wall surface anchor family protein; hypothetical protein 2861371 1213715 SAV_2346 Streptomyces avermitilis MA-4680 hypothetical protein NP_823522.1 2860718 D 227882 CDS NP_823523.1 29828889 1210406 complement(2861430..2861708) 1 NC_003155.4 gas vesicle synthesis protein 2861708 gvpK3 1210406 gvpK3 Streptomyces avermitilis MA-4680 gas vesicle synthesis protein NP_823523.1 2861430 R 227882 CDS NP_823524.1 29828890 1210407 complement(2861705..2861932) 1 NC_003155.4 gas vesicle synthesis protein 2861932 gvpS3 1210407 gvpS3 Streptomyces avermitilis MA-4680 gas vesicle synthesis protein NP_823524.1 2861705 R 227882 CDS NP_823525.1 29828891 1210408 complement(2861936..2862751) 1 NC_003155.4 gas vesicle synthesis protein 2862751 gvpL3 1210408 gvpL3 Streptomyces avermitilis MA-4680 gas vesicle synthesis protein NP_823525.1 2861936 R 227882 CDS NP_823526.1 29828892 1210409 complement(2862748..2863107) 1 NC_003155.4 gas vesicle synthesis protein 2863107 gvpJ3 1210409 gvpJ3 Streptomyces avermitilis MA-4680 gas vesicle synthesis protein NP_823526.1 2862748 R 227882 CDS NP_823527.1 29828893 1213716 complement(2863100..2864230) 1 NC_003155.4 PF03364: Streptomyces cyclase/dehydrase; hypothetical protein 2864230 1213716 SAV_2351 Streptomyces avermitilis MA-4680 hypothetical protein NP_823527.1 2863100 R 227882 CDS NP_823528.1 29828894 1213717 complement(2864237..2865367) 1 NC_003155.4 hypothetical protein 2865367 1213717 SAV_2352 Streptomyces avermitilis MA-4680 hypothetical protein NP_823528.1 2864237 R 227882 CDS NP_823529.1 29828895 1210410 complement(2865374..2865628) 1 NC_003155.4 gas vesicle synthesis protein 2865628 gvpG3 1210410 gvpG3 Streptomyces avermitilis MA-4680 gas vesicle synthesis protein NP_823529.1 2865374 R 227882 CDS NP_823530.1 29828896 1210411 complement(2865630..2866379) 1 NC_003155.4 gas vesicle synthesis protein 2866379 gvpF3 1210411 gvpF3 Streptomyces avermitilis MA-4680 gas vesicle synthesis protein NP_823530.1 2865630 R 227882 CDS NP_823531.1 29828897 1210412 complement(2866383..2866853) 1 NC_003155.4 similar to the gas vesicle synthesis protein GvpA in other bacteria but contains an extended C-terminal tail; function in the Streptomyces group is unknown but they contain several homologs of other gas vesicle synthesis proteins; gas vesicle synthesis-like protein 2866853 gvpA3 1210412 gvpA3 Streptomyces avermitilis MA-4680 gas vesicle synthesis-like protein NP_823531.1 2866383 R 227882 CDS NP_823532.1 29828898 1210413 complement(2866887..2867207) 1 NC_003155.4 gas vesicle synthesis protein 2867207 gvpO3 1210413 gvpO3 Streptomyces avermitilis MA-4680 gas vesicle synthesis protein NP_823532.1 2866887 R 227882 CDS NP_823533.1 29828899 1213718 complement(2867520..2867744) 1 NC_003155.4 hypothetical protein 2867744 1213718 SAV_2357 Streptomyces avermitilis MA-4680 hypothetical protein NP_823533.1 2867520 R 227882 CDS NP_823534.1 29828900 1213719 complement(2867801..2868622) 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 2868622 1213719 SAV_2358 Streptomyces avermitilis MA-4680 dehydrogenase NP_823534.1 2867801 R 227882 CDS NP_823535.1 29828901 1213720 2868840..2869376 1 NC_003155.4 hypothetical protein 2869376 1213720 SAV_2359 Streptomyces avermitilis MA-4680 hypothetical protein NP_823535.1 2868840 D 227882 CDS NP_823536.1 29828902 1213721 2869373..2870353 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 2870353 1213721 SAV_2360 Streptomyces avermitilis MA-4680 acetyltransferase NP_823536.1 2869373 D 227882 CDS NP_823537.1 29828903 1213722 2870350..2871699 1 NC_003155.4 sugar ABC transporter substrate-binding protein 2871699 1213722 SAV_2361 Streptomyces avermitilis MA-4680 sugar ABC transporter substrate-binding protein NP_823537.1 2870350 D 227882 CDS NP_823538.1 29828904 1213723 2871696..2872658 1 NC_003155.4 sugar ABC transporter permease 2872658 1213723 SAV_2362 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_823538.1 2871696 D 227882 CDS NP_823539.1 29828905 1213724 2872697..2873524 1 NC_003155.4 ABC transporter permease 2873524 1213724 SAV_2363 Streptomyces avermitilis MA-4680 ABC transporter permease NP_823539.1 2872697 D 227882 CDS NP_823540.1 29828906 1213725 complement(2873756..2875672) 1 NC_003155.4 ABC transporter ATP-binding protein 2875672 1213725 SAV_2364 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_823540.1 2873756 R 227882 CDS NP_823541.1 29828907 1213726 complement(2875669..2877462) 1 NC_003155.4 ABC transporter ATP-binding protein 2877462 1213726 SAV_2365 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_823541.1 2875669 R 227882 CDS NP_823542.1 29828908 1213727 2877941..2878606 1 NC_003155.4 pks5 gene cluster; hydroxylase 2878606 1213727 SAV_2366 Streptomyces avermitilis MA-4680 hydroxylase NP_823542.1 2877941 D 227882 CDS NP_823543.1 29828909 1213728 complement(2878682..2880001) 1 NC_003155.4 enzyme from Treponema denticola exhibits NADH-dependent trans-2-enoyl-CoA reductase activity; trans-2-enoyl-CoA reductase 2880001 1213728 SAV_2367 Streptomyces avermitilis MA-4680 trans-2-enoyl-CoA reductase NP_823543.1 2878682 R 227882 CDS NP_823544.1 29828910 1213729 complement(2879868..2893364) 1 NC_003155.4 pks5 gene cluster; modular polyketide synthase 2893364 pks5 1213729 pks5 Streptomyces avermitilis MA-4680 modular polyketide synthase NP_823544.1 2879868 R 227882 CDS NP_823545.1 29828911 1213730 2893601..2894413 1 NC_003155.4 pks5 gene cluster; regulatory protein 2894413 1213730 SAV_2369 Streptomyces avermitilis MA-4680 regulatory protein NP_823545.1 2893601 D 227882 CDS NP_823546.1 29828912 1213731 complement(2894488..2895315) 1 NC_003155.4 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 2895315 fabG 1213731 fabG Streptomyces avermitilis MA-4680 3-ketoacyl-ACP reductase NP_823546.1 2894488 R 227882 CDS NP_823547.1 29828913 1213732 complement(2895312..2895968) 1 NC_003155.4 two-component system response regulator 2895968 1213732 SAV_2371 Streptomyces avermitilis MA-4680 two-component system response regulator NP_823547.1 2895312 R 227882 CDS NP_823548.1 29828914 1213733 complement(2896543..2897352) 1 NC_003155.4 methyltransferase 2897352 1213733 SAV_2372 Streptomyces avermitilis MA-4680 methyltransferase NP_823548.1 2896543 R 227882 CDS NP_823549.1 29828915 1213734 complement(2897395..2897655) 1 NC_003155.4 pks9 gene cluster, similar to actIORF3; ACP 2897655 pks9-1 1213734 pks9-1 Streptomyces avermitilis MA-4680 ACP NP_823549.1 2897395 R 227882 CDS NP_823550.1 29828916 1213735 2897904..2898908 1 NC_003155.4 pks9 gene cluster; 3-oxoacyl-ACP synthase III 2898908 pks9-2 1213735 pks9-2 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP synthase III NP_823550.1 2897904 D 227882 CDS NP_823551.1 29828917 1213736 complement(2899008..2900258) 1 NC_003155.4 pks9 gene cluster, similar to actIORF2; 3-oxoacyl-ACP synthase II 2900258 pks9-3 1213736 pks9-3 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP synthase II NP_823551.1 2899008 R 227882 CDS NP_823552.1 29828918 1213737 complement(2900251..2901483) 1 NC_003155.4 pks9 gene cluster, similar to actIORF1; 3-oxoacyl-ACP synthase I 2901483 pks9-4 1213737 pks9-4 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP synthase I NP_823552.1 2900251 R 227882 CDS NP_823553.1 29828919 1210414 complement(2901616..2902815) 1 NC_003155.4 CYP107Y1, pks9 gene cluster; cytochrome P450 2902815 cyp10 1210414 cyp10 Streptomyces avermitilis MA-4680 cytochrome P450 NP_823553.1 2901616 R 227882 CDS NP_823554.1 29828920 1213738 complement(2903139..2904644) 1 NC_003155.4 pks9 gene cluster, PF01360: Monooxygenase; polyketide oxidase/hydroxylase 2904644 1213738 SAV_2378 Streptomyces avermitilis MA-4680 polyketide oxidase/hydroxylase NP_823554.1 2903139 R 227882 CDS NP_823555.1 29828921 1213739 complement(2904712..2905497) 1 NC_003155.4 pks9 gene cluster; hypothetical protein 2905497 1213739 SAV_2379 Streptomyces avermitilis MA-4680 hypothetical protein NP_823555.1 2904712 R 227882 CDS NP_823556.1 29828922 1213740 complement(2905494..2906435) 1 NC_003155.4 pks9 gene cluster; ABC transporter ATP-binding protein 2906435 1213740 SAV_2380 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_823556.1 2905494 R 227882 CDS NP_823557.1 29828923 1213741 2906589..2907374 1 NC_003155.4 pks9 gene cluster; TetR family transcriptional regulator 2907374 1213741 SAV_2381 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_823557.1 2906589 D 227882 CDS NP_823558.1 29828924 1213742 complement(2907341..2908420) 1 NC_003155.4 pks9 gene cluster; O-methyltransferase 2908420 1213742 SAV_2382 Streptomyces avermitilis MA-4680 O-methyltransferase NP_823558.1 2907341 R 227882 CDS NP_823559.1 29828925 1213743 complement(2908487..2909455) 1 NC_003155.4 pks9 gene cluster, similar to actVII; aromatase 2909455 1213743 SAV_2383 Streptomyces avermitilis MA-4680 aromatase NP_823559.1 2908487 R 227882 CDS NP_823560.1 29828926 1213744 2909637..2910314 1 NC_003155.4 pks9 gene cluster; cyclase 2910314 1213744 SAV_2384 Streptomyces avermitilis MA-4680 cyclase NP_823560.1 2909637 D 227882 CDS NP_823561.1 29828927 1210415 2910356..2911516 1 NC_003155.4 CYP181A1, pks9 gene cluster; cytochrome P450 2911516 cyp11 1210415 cyp11 Streptomyces avermitilis MA-4680 cytochrome P450 NP_823561.1 2910356 D 227882 CDS NP_823562.1 29828928 1213745 2911652..2912356 1 NC_003155.4 pks9 gene cluster; ClpX-like protein 2912356 1213745 SAV_2386 Streptomyces avermitilis MA-4680 ClpX-like protein NP_823562.1 2911652 D 227882 CDS NP_823563.1 29828929 1213746 2912795..2913535 1 NC_003155.4 pks9 gene cluster; 3-oxoacyl-ACP reductase 2913535 1213746 SAV_2387 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP reductase NP_823563.1 2912795 D 227882 CDS NP_823564.1 29828930 1213747 2914052..2914291 1 NC_003155.4 probably pseudogene; phosphopantetheinyl transferase 2914291 1213747 SAV_2388 Streptomyces avermitilis MA-4680 phosphopantetheinyl transferase NP_823564.1 2914052 D 227882 CDS NP_823565.1 29828931 1213748 complement(2914573..2915874) 1 NC_003155.4 RNA methyltransferase 2915874 1213748 SAV_2389 Streptomyces avermitilis MA-4680 RNA methyltransferase NP_823565.1 2914573 R 227882 CDS NP_823566.1 29828932 1213749 complement(2915994..2918045) 1 NC_003155.4 amino acid permease 2918045 1213749 SAV_2390 Streptomyces avermitilis MA-4680 amino acid permease NP_823566.1 2915994 R 227882 CDS NP_823567.1 29828933 1210416 2918457..2919128 1 NC_003155.4 PF02254: TrkA-N domain; potassium transporter 2919128 trkA 1210416 trkA Streptomyces avermitilis MA-4680 potassium transporter NP_823567.1 2918457 D 227882 CDS NP_823568.1 29828934 1210417 2919128..2919805 1 NC_003155.4 PF02254: TrkA-N domain; potassium transporter 2919805 trkB 1210417 trkB Streptomyces avermitilis MA-4680 potassium transporter NP_823568.1 2919128 D 227882 CDS NP_823569.1 29828935 1213750 complement(2919948..2920715) 1 NC_003155.4 hypothetical protein 2920715 1213750 SAV_2393 Streptomyces avermitilis MA-4680 hypothetical protein NP_823569.1 2919948 R 227882 CDS NP_823570.1 29828936 1213751 complement(2920719..2921237) 1 NC_003155.4 hypothetical protein 2921237 1213751 SAV_2394 Streptomyces avermitilis MA-4680 hypothetical protein NP_823570.1 2920719 R 227882 CDS NP_823571.1 29828937 1210418 complement(2921239..2921955) 1 NC_003155.4 PF00072: Response regulator receiver domain; two-component system response regulator for high-affinity potassium transport system 2921955 kdpE 1210418 kdpE Streptomyces avermitilis MA-4680 two-component system response regulator for high-affinity potassium transport system NP_823571.1 2921239 R 227882 CDS NP_823572.1 29828938 1210419 complement(2921949..2924504) 1 NC_003155.4 PF02702: Osmosensitive K+ channel His kinase sensor domain; two-component system sensor kinase for high-affinity potassium transport system 2924504 kdpD 1210419 kdpD Streptomyces avermitilis MA-4680 two-component system sensor kinase for high-affinity potassium transport system NP_823572.1 2921949 R 227882 CDS NP_823573.1 29828939 1213752 complement(2924628..2925842) 1 NC_003155.4 protein 2925842 1213752 SAV_2397 Streptomyces avermitilis MA-4680 protein NP_823573.1 2924628 R 227882 CDS NP_823574.1 29828940 1213753 complement(2926016..2926780) 1 NC_003155.4 hypothetical protein 2926780 1213753 SAV_2398 Streptomyces avermitilis MA-4680 hypothetical protein NP_823574.1 2926016 R 227882 CDS NP_823575.1 29828941 1210420 complement(2926782..2927309) 1 NC_003155.4 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 2927309 dut 1210420 dut Streptomyces avermitilis MA-4680 deoxyuridine 5'-triphosphate nucleotidohydrolase NP_823575.1 2926782 R 227882 CDS NP_823576.1 29828942 1213754 complement(2927306..2927890) 1 NC_003155.4 PF03061: Thioesterase superfamily; hypothetical protein 2927890 1213754 SAV_2400 Streptomyces avermitilis MA-4680 hypothetical protein NP_823576.1 2927306 R 227882 CDS NP_823577.1 29828943 1213755 2927949..2928410 1 NC_003155.4 protein 2928410 1213755 SAV_2401 Streptomyces avermitilis MA-4680 protein NP_823577.1 2927949 D 227882 CDS NP_823578.1 29828944 1213756 complement(2928537..2929472) 1 NC_003155.4 hypothetical protein 2929472 1213756 SAV_2402 Streptomyces avermitilis MA-4680 hypothetical protein NP_823578.1 2928537 R 227882 CDS NP_823579.1 29828945 1213757 complement(2929486..2929782) 1 NC_003155.4 hypothetical protein 2929782 1213757 SAV_2403 Streptomyces avermitilis MA-4680 hypothetical protein NP_823579.1 2929486 R 227882 CDS NP_823580.1 29828946 1210421 complement(2930179..2931426) 1 NC_003155.4 transfer copper to melC; two-component system sensor kinase 2931426 cutS 1210421 cutS Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_823580.1 2930179 R 227882 CDS NP_823581.1 29828947 1210422 complement(2931433..2932086) 1 NC_003155.4 two-component system response regulator 2932086 cutR 1210422 cutR Streptomyces avermitilis MA-4680 two-component system response regulator NP_823581.1 2931433 R 227882 CDS NP_823582.1 29828948 1210423 complement(2932782..2933600) 1 NC_003155.4 spectinomycin resistance or Li+ sensitivity. extragenic suppressor protein homolog, PF00459: Inositol monophosphatase family; myo-inositol 1-monophosphatase 2933600 suhB1 1210423 suhB1 Streptomyces avermitilis MA-4680 myo-inositol 1-monophosphatase NP_823582.1 2932782 R 227882 CDS NP_823583.1 29828949 1210424 complement(2933609..2934736) 1 NC_003155.4 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 2934736 hemH 1210424 hemH Streptomyces avermitilis MA-4680 ferrochelatase NP_823583.1 2933609 R 227882 CDS NP_823584.1 29828950 1213758 2934898..2936136 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 2936136 1213758 SAV_2408 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_823584.1 2934898 D 227882 CDS NP_823585.1 29828951 1213759 2936096..2937415 1 NC_003155.4 PF01565: FAD binding domain; FAD-dependent oxidoreductase 2937415 1213759 SAV_2409 Streptomyces avermitilis MA-4680 FAD-dependent oxidoreductase NP_823585.1 2936096 D 227882 CDS NP_823586.1 29828952 1213760 complement(2937339..2938130) 1 NC_003155.4 hypothetical protein 2938130 1213760 SAV_2410 Streptomyces avermitilis MA-4680 hypothetical protein NP_823586.1 2937339 R 227882 CDS NP_823587.1 29828953 1213761 2938603..2939649 1 NC_003155.4 DNA-binding protein 2939649 1213761 SAV_2411 Streptomyces avermitilis MA-4680 DNA-binding protein NP_823587.1 2938603 D 227882 CDS NP_823588.1 29828954 1210425 complement(2939732..2940583) 1 NC_003155.4 thiosulfate sulfurtransferase 2940583 sseB 1210425 sseB Streptomyces avermitilis MA-4680 thiosulfate sulfurtransferase NP_823588.1 2939732 R 227882 CDS NP_823589.1 29828955 1213762 2940907..2941710 1 NC_003155.4 SgaA homolog; hydroxylase 2941710 1213762 SAV_2413 Streptomyces avermitilis MA-4680 hydroxylase NP_823589.1 2940907 D 227882 CDS NP_823590.1 29828956 1210426 complement(2941783..2942433) 1 NC_003155.4 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 2942433 tdk 1210426 tdk Streptomyces avermitilis MA-4680 thymidine kinase NP_823590.1 2941783 R 227882 CDS NP_823591.1 29828957 1213763 complement(2942495..2943682) 1 NC_003155.4 PF01663: Type I phosphodiesterase / nucleotide pyrophosphatase; phosphodiesterase 2943682 1213763 SAV_2415 Streptomyces avermitilis MA-4680 phosphodiesterase NP_823591.1 2942495 R 227882 CDS NP_823592.1 29828958 1213764 complement(2943682..2944269) 1 NC_003155.4 hypothetical protein 2944269 1213764 SAV_2416 Streptomyces avermitilis MA-4680 hypothetical protein NP_823592.1 2943682 R 227882 CDS NP_823593.1 29828959 1213765 complement(2944322..2947171) 1 NC_003155.4 acyl-CoA synthetase (NDP forming type) 2947171 acdA2 1213765 acdA2 Streptomyces avermitilis MA-4680 acyl-CoA synthetase (NDP forming type) NP_823593.1 2944322 R 227882 CDS NP_823594.1 29828960 1210427 2947307..2947588 1 NC_003155.4 PF00381: PTS HPr component phosphorylation site; phosphocarrier protein 2947588 hpr 1210427 hpr Streptomyces avermitilis MA-4680 phosphocarrier protein NP_823594.1 2947307 D 227882 CDS NP_823595.1 29828961 1213766 complement(2947869..2948564) 1 NC_003155.4 GntR family transcriptional regulator 2948564 1213766 SAV_2419 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_823595.1 2947869 R 227882 CDS NP_823596.1 29828962 1213767 complement(2948761..2949537) 1 NC_003155.4 PF01551: Peptidase family M23; peptidase 2949537 1213767 SAV_2420 Streptomyces avermitilis MA-4680 peptidase NP_823596.1 2948761 R 227882 CDS NP_823597.1 29828963 1213768 complement(2949913..2951301) 1 NC_003155.4 PF05193: Peptidase M16 inactive domain; protease 2951301 1213768 SAV_2421 Streptomyces avermitilis MA-4680 protease NP_823597.1 2949913 R 227882 CDS NP_823598.1 29828964 1213769 complement(2951298..2952662) 1 NC_003155.4 PF05193: Peptidase M16 inactive domain; protease 2952662 1213769 SAV_2422 Streptomyces avermitilis MA-4680 protease NP_823598.1 2951298 R 227882 CDS NP_823599.1 29828965 1210428 2952967..2955423 1 NC_003155.4 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 2955423 parC 1210428 parC Streptomyces avermitilis MA-4680 DNA topoisomerase IV subunit A NP_823599.1 2952967 D 227882 CDS NP_823600.1 29828966 1210429 complement(2955436..2956521) 1 NC_003155.4 cobalamin biosynthesis, PF02492: CobW/HypB/UreG, nucleotide-binding domain; cobalamin synthesis protein 2956521 cobW 1210429 cobW Streptomyces avermitilis MA-4680 cobalamin synthesis protein NP_823600.1 2955436 R 227882 CDS NP_823601.1 29828967 1213770 2956894..2957415 1 NC_003155.4 protein 2957415 1213770 SAV_2425 Streptomyces avermitilis MA-4680 protein NP_823601.1 2956894 D 227882 CDS NP_823602.1 29828968 1213771 2957588..2957917 1 NC_003155.4 hypothetical protein 2957917 1213771 SAV_2426 Streptomyces avermitilis MA-4680 hypothetical protein NP_823602.1 2957588 D 227882 CDS NP_823603.1 29828969 1210430 complement(2957989..2959155) 1 NC_003155.4 citrate synthase 2959155 citA3 1210430 citA3 Streptomyces avermitilis MA-4680 citrate synthase NP_823603.1 2957989 R 227882 CDS NP_823604.1 29828970 1213772 2959252..2960508 1 NC_003155.4 PF00285: Citrate synthase; citrate synthase-like protein 2960508 1213772 SAV_2428 Streptomyces avermitilis MA-4680 citrate synthase-like protein NP_823604.1 2959252 D 227882 CDS NP_823605.1 29828971 1213773 2960607..2961554 1 NC_003155.4 PF06091: Bacterial protein of unknown function (DUF942); hypothetical protein 2961554 1213773 SAV_2429 Streptomyces avermitilis MA-4680 hypothetical protein NP_823605.1 2960607 D 227882 CDS NP_823606.1 29828972 1213774 2961753..2963480 1 NC_003155.4 two-component system sensor kinase 2963480 1213774 SAV_2430 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_823606.1 2961753 D 227882 CDS NP_823607.1 29828973 1213775 2963477..2964166 1 NC_003155.4 two-component system response regulator 2964166 1213775 SAV_2431 Streptomyces avermitilis MA-4680 two-component system response regulator NP_823607.1 2963477 D 227882 CDS NP_823608.1 29828974 1213776 complement(2964195..2965256) 1 NC_003155.4 ABC transporter substrate-binding protein 2965256 1213776 SAV_2432 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_823608.1 2964195 R 227882 CDS NP_823609.1 29828975 1213777 complement(2965387..2966280) 1 NC_003155.4 ABC transporter permease 2966280 1213777 SAV_2433 Streptomyces avermitilis MA-4680 ABC transporter permease NP_823609.1 2965387 R 227882 CDS NP_823610.1 29828976 1213778 complement(2966252..2967103) 1 NC_003155.4 ABC transporter ATP-binding protein 2967103 1213778 SAV_2434 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_823610.1 2966252 R 227882 CDS NP_823611.1 29828977 1213779 2967230..2967922 1 NC_003155.4 two-component system response regulator 2967922 1213779 SAV_2435 Streptomyces avermitilis MA-4680 two-component system response regulator NP_823611.1 2967230 D 227882 CDS NP_823612.1 29828978 1213780 complement(2967960..2969552) 1 NC_003155.4 PF00474: Sodium:solute symporter family; sodium:solute symporter 2969552 1213780 SAV_2436 Streptomyces avermitilis MA-4680 sodium:solute symporter NP_823612.1 2967960 R 227882 CDS NP_823613.1 29828979 1213781 complement(2969549..2970079) 1 NC_003155.4 PF04341: Protein of unknown function, DUF485; hypothetical protein 2970079 1213781 SAV_2437 Streptomyces avermitilis MA-4680 hypothetical protein NP_823613.1 2969549 R 227882 CDS NP_823614.1 29828980 1213782 complement(2970142..2970825) 1 NC_003155.4 two-component system response regulator 2970825 1213782 SAV_2438 Streptomyces avermitilis MA-4680 two-component system response regulator NP_823614.1 2970142 R 227882 CDS NP_823615.1 29828981 1213783 complement(2970822..2971976) 1 NC_003155.4 two-component system sensor kinase 2971976 1213783 SAV_2439 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_823615.1 2970822 R 227882 CDS NP_823616.1 29828982 1213784 complement(2971973..2972521) 1 NC_003155.4 integral membrane protein 2972521 1213784 SAV_2440 Streptomyces avermitilis MA-4680 integral membrane protein NP_823616.1 2971973 R 227882 CDS NP_823617.1 29828983 1213785 complement(2972580..2972771) 1 NC_003155.4 hypothetical protein 2972771 1213785 SAV_2441 Streptomyces avermitilis MA-4680 hypothetical protein NP_823617.1 2972580 R 227882 CDS NP_823618.1 29828984 1210431 complement(2972825..2974948) 1 NC_003155.4 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 2974948 parE 1210431 parE Streptomyces avermitilis MA-4680 DNA topoisomerase IV subunit B NP_823618.1 2972825 R 227882 CDS NP_823619.1 29828985 1213786 complement(2975869..2976687) 1 NC_003155.4 PF00089: Trypsin; serine protease 2976687 1213786 SAV_2443 Streptomyces avermitilis MA-4680 serine protease NP_823619.1 2975869 R 227882 CDS NP_823620.1 29828986 1210432 complement(2976855..2978393) 1 NC_003155.4 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; RNA polymerase sigma factor 2978393 rpoD 1210432 rpoD Streptomyces avermitilis MA-4680 RNA polymerase sigma factor NP_823620.1 2976855 R 227882 CDS NP_823621.1 29828987 1213787 complement(2979000..2979863) 1 NC_003155.4 GntR-family transcriptional regulator; sporulation transcription factor 2979863 whiH 1213787 whiH Streptomyces avermitilis MA-4680 sporulation transcription factor NP_823621.1 2979000 R 227882 CDS NP_823622.1 29828988 1213788 complement(2980050..2981795) 1 NC_003155.4 ABC transporter ATP-binding protein 2981795 1213788 SAV_2446 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_823622.1 2980050 R 227882 CDS NP_823623.1 29828989 1213789 complement(2981909..2982661) 1 NC_003155.4 PF00293: NUDIX domain; DNA hydrolase 2982661 1213789 SAV_2447 Streptomyces avermitilis MA-4680 DNA hydrolase NP_823623.1 2981909 R 227882 CDS NP_823624.1 29828990 1213790 complement(2982785..2985184) 1 NC_003155.4 glycogen debranching enzyme 2985184 1213790 SAV_2448 Streptomyces avermitilis MA-4680 glycogen debranching enzyme NP_823624.1 2982785 R 227882 CDS NP_823625.1 29828991 1213791 complement(2985293..2987020) 1 NC_003155.4 hypothetical protein 2987020 1213791 SAV_2449 Streptomyces avermitilis MA-4680 hypothetical protein NP_823625.1 2985293 R 227882 CDS NP_823626.1 29828992 1213792 2987332..2989536 1 NC_003155.4 PF00270: DEAD/DEAH box helicase; ATP-dependent DNA helicase 2989536 1213792 SAV_2450 Streptomyces avermitilis MA-4680 ATP-dependent DNA helicase NP_823626.1 2987332 D 227882 CDS NP_823627.1 29828993 1213793 2989772..2990407 1 NC_003155.4 hypothetical protein 2990407 1213793 SAV_2451 Streptomyces avermitilis MA-4680 hypothetical protein NP_823627.1 2989772 D 227882 CDS NP_823628.1 29828994 1213794 complement(2990953..2991579) 1 NC_003155.4 hypothetical protein 2991579 1213794 SAV_2452 Streptomyces avermitilis MA-4680 hypothetical protein NP_823628.1 2990953 R 227882 CDS NP_823629.1 29828995 1210433 complement(2991649..2992350) 1 NC_003155.4 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 2992350 rnhB 1210433 rnhB Streptomyces avermitilis MA-4680 ribonuclease HII NP_823629.1 2991649 R 227882 CDS NP_823630.1 29828996 1213795 complement(2992627..2993250) 1 NC_003155.4 TetR family transcriptional regulator 2993250 1213795 SAV_2454 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_823630.1 2992627 R 227882 CDS NP_823631.1 29828997 1213796 2993440..2994999 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 2994999 1213796 SAV_2455 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_823631.1 2993440 D 227882 CDS NP_823632.1 29828998 1213797 complement(2995226..2997046) 1 NC_003155.4 hypothetical protein 2997046 1213797 SAV_2456 Streptomyces avermitilis MA-4680 hypothetical protein NP_823632.1 2995226 R 227882 CDS NP_823633.1 29828999 1213798 complement(2997383..2998288) 1 NC_003155.4 PF03747: ADP-ribosylglycohydrolase; hydrolase 2998288 1213798 SAV_2457 Streptomyces avermitilis MA-4680 hydrolase NP_823633.1 2997383 R 227882 CDS NP_823634.1 29829000 1213799 complement(2998301..2998960) 1 NC_003155.4 PF00300: Phosphoglycerate mutase family; hypothetical protein 2998960 1213799 SAV_2458 Streptomyces avermitilis MA-4680 hypothetical protein NP_823634.1 2998301 R 227882 CDS NP_823635.1 29829001 1213800 complement(2999154..2999759) 1 NC_003155.4 hypothetical protein 2999759 1213800 SAV_2459 Streptomyces avermitilis MA-4680 hypothetical protein NP_823635.1 2999154 R 227882 CDS NP_823636.1 29829002 1213801 2999916..3000449 1 NC_003155.4 hypothetical protein 3000449 1213801 SAV_2460 Streptomyces avermitilis MA-4680 hypothetical protein NP_823636.1 2999916 D 227882 CDS NP_823637.1 29829003 1210434 complement(3000542..3003436) 1 NC_003155.4 catalyzes the reduction of ribonucleotides to deoxyribonucleotides; the rate-limiting step in dNTP synthesis; vitamin B12-dependent ribonucleotide reductase 3003436 nrdA 1210434 nrdA Streptomyces avermitilis MA-4680 vitamin B12-dependent ribonucleotide reductase NP_823637.1 3000542 R 227882 CDS NP_823638.1 29829004 1213802 complement(3003586..3004149) 1 NC_003155.4 transcriptional regulator NrdR 3004149 nrdR 1213802 nrdR Streptomyces avermitilis MA-4680 transcriptional regulator NrdR NP_823638.1 3003586 R 227882 CDS NP_823639.1 29829005 1210435 3004668..3005447 1 NC_003155.4 Represses a number of genes involved in the response to DNA damage; LexA repressor 3005447 lexA 1210435 lexA Streptomyces avermitilis MA-4680 LexA repressor NP_823639.1 3004668 D 227882 CDS NP_823640.1 29829006 1210436 complement(3005610..3007643) 1 NC_003155.4 ATP-dependent helicase 3007643 dinG 1210436 dinG Streptomyces avermitilis MA-4680 ATP-dependent helicase NP_823640.1 3005610 R 227882 CDS NP_823641.1 29829007 1213803 complement(3007876..3009009) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; hypothetical protein 3009009 1213803 SAV_2465 Streptomyces avermitilis MA-4680 hypothetical protein NP_823641.1 3007876 R 227882 CDS NP_823642.1 29829008 1213804 complement(3009049..3011109) 1 NC_003155.4 iron transport protein 3011109 1213804 SAV_2466 Streptomyces avermitilis MA-4680 iron transport protein NP_823642.1 3009049 R 227882 CDS NP_823643.1 29829009 1213805 complement(3011275..3012729) 1 NC_003155.4 class III aminotransferase 3012729 1213805 SAV_2467 Streptomyces avermitilis MA-4680 class III aminotransferase NP_823643.1 3011275 R 227882 CDS NP_823644.1 29829010 1213806 3013261..3014493 1 NC_003155.4 protein 3014493 1213806 SAV_2468 Streptomyces avermitilis MA-4680 protein NP_823644.1 3013261 D 227882 CDS NP_823645.1 29829011 1213807 3014689..3015882 1 NC_003155.4 protein 3015882 1213807 SAV_2469 Streptomyces avermitilis MA-4680 protein NP_823645.1 3014689 D 227882 CDS NP_823646.1 29829012 1213808 complement(3015948..3017441) 1 NC_003155.4 ATP/GTP-binding protein 3017441 1213808 SAV_2470 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_823646.1 3015948 R 227882 CDS NP_823647.1 29829013 1213809 complement(3017627..3019096) 1 NC_003155.4 PF01433: Peptidase family M1; metallopeptidase 3019096 1213809 SAV_2471 Streptomyces avermitilis MA-4680 metallopeptidase NP_823647.1 3017627 R 227882 CDS NP_823648.1 29829014 1210437 complement(3019308..3021470) 1 NC_003155.4 PF04607: Region found in RelA / SpoT proteins; ppGpp synthetase/hydrolase 3021470 relA1 1210437 relA1 Streptomyces avermitilis MA-4680 ppGpp synthetase/hydrolase NP_823648.1 3019308 R 227882 CDS NP_823649.1 29829015 1210438 complement(3021769..3022638) 1 NC_003155.4 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 3022638 dapF 1210438 dapF Streptomyces avermitilis MA-4680 diaminopimelate epimerase NP_823649.1 3021769 R 227882 CDS NP_823650.1 29829016 1213810 complement(3022962..3023495) 1 NC_003155.4 hypothetical protein 3023495 1213810 SAV_2474 Streptomyces avermitilis MA-4680 hypothetical protein NP_823650.1 3022962 R 227882 CDS NP_823651.1 29829017 1210439 complement(3023598..3024536) 1 NC_003155.4 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 3024536 miaA 1210439 miaA Streptomyces avermitilis MA-4680 tRNA delta(2)-isopentenylpyrophosphate transferase NP_823651.1 3023598 R 227882 CDS NP_823652.1 29829018 1213811 3024719..3025084 1 NC_003155.4 hypothetical protein 3025084 1213811 SAV_2476 Streptomyces avermitilis MA-4680 hypothetical protein NP_823652.1 3024719 D 227882 CDS NP_823653.1 29829019 1213812 3025109..3025384 1 NC_003155.4 hypothetical protein 3025384 1213812 SAV_2477 Streptomyces avermitilis MA-4680 hypothetical protein NP_823653.1 3025109 D 227882 CDS NP_823654.1 29829020 1213813 complement(3025529..3026248) 1 NC_003155.4 PF02900: Catalytic LigB subunit of aromatic ring-opening dioxygenase; hypothetical protein 3026248 1213813 SAV_2478 Streptomyces avermitilis MA-4680 hypothetical protein NP_823654.1 3025529 R 227882 CDS NP_823655.1 29829021 1213814 complement(3026318..3027844) 1 NC_003155.4 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 3027844 1213814 SAV_2479 Streptomyces avermitilis MA-4680 (dimethylallyl)adenosine tRNA methylthiotransferase NP_823655.1 3026318 R 227882 CDS NP_823656.1 29829022 1213815 complement(3027958..3028434) 1 NC_003155.4 PF03819: MazG nucleotide pyrophosphohydrolase domain; hypothetical protein 3028434 1213815 SAV_2480 Streptomyces avermitilis MA-4680 hypothetical protein NP_823656.1 3027958 R 227882 CDS NP_823657.1 29829023 1213816 3028547..3029545 1 NC_003155.4 PF03466: LysR substrate binding domain; protein 3029545 1213816 SAV_2481 Streptomyces avermitilis MA-4680 protein NP_823657.1 3028547 D 227882 CDS NP_823658.1 29829024 1213817 complement(3029568..3030974) 1 NC_003155.4 two-component system sensor kinase 3030974 1213817 SAV_2482 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_823658.1 3029568 R 227882 CDS NP_823659.1 29829025 1213818 complement(3030984..3031670) 1 NC_003155.4 two-component system response regulator 3031670 1213818 SAV_2483 Streptomyces avermitilis MA-4680 two-component system response regulator NP_823659.1 3030984 R 227882 CDS NP_823660.1 29829026 1210440 3031983..3032759 1 NC_003155.4 ABC transporter ATP-binding protein; glutamate uptake system ATP-binding protein 3032759 gluA2 1210440 gluA2 Streptomyces avermitilis MA-4680 glutamate uptake system ATP-binding protein NP_823660.1 3031983 D 227882 CDS NP_823661.1 29829027 1210441 3032876..3033709 1 NC_003155.4 ABC transporter substrate-binding protein; glutamate ABC transporter substrate-binding protein 3033709 gluB2 1210441 gluB2 Streptomyces avermitilis MA-4680 glutamate ABC transporter substrate-binding protein NP_823661.1 3032876 D 227882 CDS NP_823662.1 29829028 1210442 3033795..3034460 1 NC_003155.4 ABC transporter permease; glutamate ABC transporter permease 3034460 gluC2 1210442 gluC2 Streptomyces avermitilis MA-4680 glutamate ABC transporter permease NP_823662.1 3033795 D 227882 CDS NP_823663.1 29829029 1210443 3034457..3035362 1 NC_003155.4 ABC transporter permease; glutamate ABC transporter permease 3035362 gluD2 1210443 gluD2 Streptomyces avermitilis MA-4680 glutamate ABC transporter permease NP_823663.1 3034457 D 227882 CDS NP_823664.1 29829030 1213819 3035563..3037428 1 NC_003155.4 PF01360: Monooxygenase; monooxygenase 3037428 1213819 SAV_2488 Streptomyces avermitilis MA-4680 monooxygenase NP_823664.1 3035563 D 227882 CDS NP_823665.1 29829031 1213820 3037719..3038264 1 NC_003155.4 PF05995: cysteine dioxygenase type I; cysteine dioxygenase 3038264 cdo1 1213820 cdo1 Streptomyces avermitilis MA-4680 cysteine dioxygenase NP_823665.1 3037719 D 227882 CDS NP_823666.1 29829032 1213821 3038261..3038662 1 NC_003155.4 PF00581: Rhodanese-like domain; hypothetical protein 3038662 1213821 SAV_2490 Streptomyces avermitilis MA-4680 hypothetical protein NP_823666.1 3038261 D 227882 CDS NP_823667.2 161511222 1210444 complement(3038800..3039597) 1 NC_003155.4 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 3039597 recX 1210444 recX Streptomyces avermitilis MA-4680 recombination regulator RecX NP_823667.2 3038800 R 227882 CDS NP_823668.1 29829034 1210445 complement(3039751..3040884) 1 NC_003155.4 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 3040884 recA 1210445 recA Streptomyces avermitilis MA-4680 recombinase A NP_823668.1 3039751 R 227882 CDS NP_823669.1 29829035 1213822 3041349..3042380 1 NC_003155.4 hypothetical protein 3042380 1213822 SAV_2493 Streptomyces avermitilis MA-4680 hypothetical protein NP_823669.1 3041349 D 227882 CDS NP_823670.1 29829036 1213823 complement(3042423..3043574) 1 NC_003155.4 PF01594: Domain of unknown function DUF20; hypothetical protein 3043574 1213823 SAV_2494 Streptomyces avermitilis MA-4680 hypothetical protein NP_823670.1 3042423 R 227882 CDS NP_823671.1 29829037 1213824 complement(3043786..3043980) 1 NC_003155.4 hypothetical protein 3043980 1213824 SAV_2495 Streptomyces avermitilis MA-4680 hypothetical protein NP_823671.1 3043786 R 227882 CDS NP_823672.1 29829038 1213825 3044061..3045005 1 NC_003155.4 hypothetical protein 3045005 1213825 SAV_2496 Streptomyces avermitilis MA-4680 hypothetical protein NP_823672.1 3044061 D 227882 CDS NP_823673.1 29829039 1213826 complement(3045039..3045347) 1 NC_003155.4 PF06063: Domain of unknown function (DUF931); hypothetical protein 3045347 1213826 SAV_2497 Streptomyces avermitilis MA-4680 hypothetical protein NP_823673.1 3045039 R 227882 CDS NP_823674.1 29829040 1213827 complement(3045344..3046252) 1 NC_003155.4 PF03591: AzlC protein; hypothetical protein 3046252 1213827 SAV_2498 Streptomyces avermitilis MA-4680 hypothetical protein NP_823674.1 3045344 R 227882 CDS NP_823675.1 29829041 1213828 complement(3046200..3047096) 1 NC_003155.4 AraC family transcription regulator 3047096 1213828 SAV_2499 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_823675.1 3046200 R 227882 CDS NP_823676.1 29829042 1210446 3047311..3052287 1 NC_003155.4 PF00270: DEAD/DEAH box helicase; ATP-dependent DNA helicase 3052287 lhr 1210446 lhr Streptomyces avermitilis MA-4680 ATP-dependent DNA helicase NP_823676.1 3047311 D 227882 CDS NP_823677.1 29829043 1210447 3052491..3053333 1 NC_003155.4 involved in DNA repair; nick DNA at apurinic/apyrimidinic sites. PF01149: Formamidopyrimidine-DNA glycosylase N-terminal domain; endonuclease VIII and DNA N-glycosylase with an AP lyase activity 3053333 nei1 1210447 nei1 Streptomyces avermitilis MA-4680 endonuclease VIII and DNA N-glycosylase with an AP lyase activity NP_823677.1 3052491 D 227882 CDS NP_823678.1 29829044 1210448 3053367..3054131 1 NC_003155.4 PF00106: short chain dehydrogenase; 3-oxoacyl-ACP reductase 3054131 fabG3 1210448 fabG3 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP reductase NP_823678.1 3053367 D 227882 CDS NP_823679.1 29829045 1213829 complement(3054324..3054602) 1 NC_003155.4 hypothetical protein 3054602 1213829 SAV_2503 Streptomyces avermitilis MA-4680 hypothetical protein NP_823679.1 3054324 R 227882 CDS NP_823680.1 29829046 1213830 complement(3054804..3055274) 1 NC_003155.4 PF00210: ferritin-like domain; starvation-induced DNA protecting protein 3055274 mrgA2 1213830 mrgA2 Streptomyces avermitilis MA-4680 starvation-induced DNA protecting protein NP_823680.1 3054804 R 227882 CDS NP_823681.1 29829047 1213831 complement(3055519..3055896) 1 NC_003155.4 DNA-binding protein 3055896 1213831 SAV_2505 Streptomyces avermitilis MA-4680 DNA-binding protein NP_823681.1 3055519 R 227882 CDS NP_823682.1 29829048 1213832 complement(3056006..3056551) 1 NC_003155.4 competence-damage inducible protein 3056551 1213832 SAV_2506 Streptomyces avermitilis MA-4680 competence-damage inducible protein NP_823682.1 3056006 R 227882 CDS NP_823683.1 29829049 1210449 complement(3056548..3057396) 1 NC_003155.4 phosphatidylglycerophosphate synthase 3057396 pgsA1 1210449 pgsA1 Streptomyces avermitilis MA-4680 phosphatidylglycerophosphate synthase NP_823683.1 3056548 R 227882 CDS NP_823684.1 29829050 1213833 complement(3057393..3058880) 1 NC_003155.4 PF00919: Uncharacterized protein family UPF0004; hypothetical protein 3058880 1213833 SAV_2508 Streptomyces avermitilis MA-4680 hypothetical protein NP_823684.1 3057393 R 227882 CDS NP_823685.1 29829051 1213834 complement(3058992..3059888) 1 NC_003155.4 hypothetical protein 3059888 1213834 SAV_2509 Streptomyces avermitilis MA-4680 hypothetical protein NP_823685.1 3058992 R 227882 CDS NP_823686.1 29829052 1210450 complement(3060126..3062879) 1 NC_003155.4 DNA translocase FtsK 3062879 ftsK 1210450 ftsK Streptomyces avermitilis MA-4680 DNA translocase FtsK NP_823686.1 3060126 R 227882 CDS NP_823687.1 29829053 1213835 complement(3062987..3063673) 1 NC_003155.4 two-component system response regulator 3063673 1213835 SAV_2511 Streptomyces avermitilis MA-4680 two-component system response regulator NP_823687.1 3062987 R 227882 CDS NP_823688.1 29829054 1213836 complement(3063948..3069437) 1 NC_003155.4 two-component system sensor kinase 3069437 1213836 SAV_2512 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_823688.1 3063948 R 227882 CDS NP_823689.1 29829055 1213837 3069826..3072573 1 NC_003155.4 PF01590: GAF domain; magnesium or manganese-dependent protein phosphatase 3072573 prpM2 1213837 prpM2 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_823689.1 3069826 D 227882 CDS NP_823690.1 29829056 1213838 complement(3072791..3073468) 1 NC_003155.4 PF01041: DegT/DnrJ/EryC1/StrS aminotransferase family; hypothetical protein 3073468 1213838 SAV_2514 Streptomyces avermitilis MA-4680 hypothetical protein NP_823690.1 3072791 R 227882 CDS NP_823691.1 29829057 1213839 complement(3079351..3081036) 1 NC_003155.4 PF00753: Metallo-beta-lactamase superfamily; metallo-beta-lactamase superfamily hydrolase 3081036 1213839 SAV_2515 Streptomyces avermitilis MA-4680 metallo-beta-lactamase superfamily hydrolase NP_823691.1 3079351 R 227882 CDS NP_823692.1 29829058 1210455 complement(3081165..3082064) 1 NC_003155.4 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 3082064 dapA 1210455 dapA Streptomyces avermitilis MA-4680 dihydrodipicolinate synthase NP_823692.1 3081165 R 227882 CDS NP_823693.1 29829059 1210456 complement(3082295..3083035) 1 NC_003155.4 flavin dependent thymidylate synthase; ThyX; thymidylate synthase complementing protein; catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate; the enzyme from Mycobacterium tuberculosis forms homotetramers; uses FAD as a cofactor; FAD-dependent thymidylate synthase 3083035 thyX 1210456 thyX Streptomyces avermitilis MA-4680 FAD-dependent thymidylate synthase NP_823693.1 3082295 R 227882 CDS NP_823694.1 29829060 1213840 3083239..3083478 1 NC_003155.4 hypothetical protein 3083478 1213840 SAV_2518 Streptomyces avermitilis MA-4680 hypothetical protein NP_823694.1 3083239 D 227882 CDS NP_823695.1 29829061 1213841 3083604..3084161 1 NC_003155.4 hypothetical protein 3084161 1213841 SAV_2519 Streptomyces avermitilis MA-4680 hypothetical protein NP_823695.1 3083604 D 227882 CDS NP_823696.1 29829062 1213842 complement(3084239..3084691) 1 NC_003155.4 PF00515: TPR Domain; hypothetical protein 3084691 1213842 SAV_2520 Streptomyces avermitilis MA-4680 hypothetical protein NP_823696.1 3084239 R 227882 CDS NP_823697.1 29829063 1210457 complement(3084697..3085449) 1 NC_003155.4 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 3085449 dapB 1210457 dapB Streptomyces avermitilis MA-4680 dihydrodipicolinate reductase NP_823697.1 3084697 R 227882 CDS NP_823698.1 29829064 1213843 complement(3085474..3086853) 1 NC_003155.4 PF05193: Peptidase M16 inactive domain; protease 3086853 1213843 SAV_2522 Streptomyces avermitilis MA-4680 protease NP_823698.1 3085474 R 227882 CDS NP_823699.1 29829065 1210458 complement(3086850..3089066) 1 NC_003155.4 polynucleotide phosphorylase/polyadenylase 3089066 pnp 1210458 pnp Streptomyces avermitilis MA-4680 polynucleotide phosphorylase/polyadenylase NP_823699.1 3086850 R 227882 CDS NP_823700.1 29829066 1210459 complement(3089414..3089701) 1 NC_003155.4 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 3089701 rpsO 1210459 rpsO Streptomyces avermitilis MA-4680 30S ribosomal protein S15 NP_823700.1 3089414 R 227882 CDS NP_823701.1 29829067 1213844 complement(3089920..3091380) 1 NC_003155.4 PF01011: PQQ enzyme repeat; hypothetical protein 3091380 1213844 SAV_2525 Streptomyces avermitilis MA-4680 hypothetical protein NP_823701.1 3089920 R 227882 CDS NP_823702.1 29829068 1213845 complement(3091623..3093125) 1 NC_003155.4 PF01011: PQQ enzyme repeat; hypothetical protein 3093125 1213845 SAV_2526 Streptomyces avermitilis MA-4680 hypothetical protein NP_823702.1 3091623 R 227882 CDS NP_823703.1 29829069 1213846 complement(3093280..3094788) 1 NC_003155.4 PF04600: Protein of unknown function (DUF571); hypothetical protein 3094788 1213846 SAV_2527 Streptomyces avermitilis MA-4680 hypothetical protein NP_823703.1 3093280 R 227882 CDS NP_823704.1 29829070 1213847 3095123..3099094 1 NC_003155.4 FtsK/SpoIIIE family protein 3099094 1213847 SAV_2528 Streptomyces avermitilis MA-4680 FtsK/SpoIIIE family protein NP_823704.1 3095123 D 227882 CDS NP_823705.1 29829071 1210460 3099241..3099561 1 NC_003155.4 BldB protein 3099561 bldB 1210460 bldB Streptomyces avermitilis MA-4680 BldB protein NP_823705.1 3099241 D 227882 CDS NP_823706.1 29829072 1213848 3099693..3100982 1 NC_003155.4 hypothetical protein 3100982 1213848 SAV_2530 Streptomyces avermitilis MA-4680 hypothetical protein NP_823706.1 3099693 D 227882 CDS NP_823707.1 29829073 1213849 complement(3101017..3102105) 1 NC_003155.4 hypothetical protein 3102105 1213849 SAV_2531 Streptomyces avermitilis MA-4680 hypothetical protein NP_823707.1 3101017 R 227882 CDS NP_823708.1 29829074 1213850 complement(3102549..3102848) 1 NC_003155.4 PF06013: Proteins of 100 residues with WXG; hypothetical protein 3102848 1213850 SAV_2532 Streptomyces avermitilis MA-4680 hypothetical protein NP_823708.1 3102549 R 227882 CDS NP_823709.1 29829075 1213851 complement(3102929..3103279) 1 NC_003155.4 hypothetical protein 3103279 1213851 SAV_2533 Streptomyces avermitilis MA-4680 hypothetical protein NP_823709.1 3102929 R 227882 CDS NP_823710.1 29829076 1213852 complement(3103399..3104616) 1 NC_003155.4 PF00082: Subtilase family; serine protease 3104616 1213852 SAV_2534 Streptomyces avermitilis MA-4680 serine protease NP_823710.1 3103399 R 227882 CDS NP_823711.1 29829077 1213853 complement(3104717..3106504) 1 NC_003155.4 hypothetical protein 3106504 1213853 SAV_2535 Streptomyces avermitilis MA-4680 hypothetical protein NP_823711.1 3104717 R 227882 CDS NP_823712.1 29829078 1213854 complement(3106501..3107028) 1 NC_003155.4 hypothetical protein 3107028 1213854 SAV_2536 Streptomyces avermitilis MA-4680 hypothetical protein NP_823712.1 3106501 R 227882 CDS NP_823713.1 29829079 1213855 3107404..3107856 1 NC_003155.4 hypothetical protein 3107856 1213855 SAV_2537 Streptomyces avermitilis MA-4680 hypothetical protein NP_823713.1 3107404 D 227882 CDS NP_823714.1 29829080 1213856 3107861..3110161 1 NC_003155.4 hypothetical protein 3110161 1213856 SAV_2538 Streptomyces avermitilis MA-4680 hypothetical protein NP_823714.1 3107861 D 227882 CDS NP_823715.1 29829081 1213857 complement(3111308..3111895) 1 NC_003155.4 hypothetical protein 3111895 1213857 SAV_2539 Streptomyces avermitilis MA-4680 hypothetical protein NP_823715.1 3111308 R 227882 CDS NP_823716.1 29829082 1213858 complement(3111892..3113190) 1 NC_003155.4 PF00082: Subtilase family; serine protease 3113190 1213858 SAV_2540 Streptomyces avermitilis MA-4680 serine protease NP_823716.1 3111892 R 227882 CDS NP_823717.1 29829083 1213859 complement(3113221..3114744) 1 NC_003155.4 PF05108: Protein of unknown function (DUF690); hypothetical protein 3114744 1213859 SAV_2541 Streptomyces avermitilis MA-4680 hypothetical protein NP_823717.1 3113221 R 227882 CDS NP_823718.1 29829084 1213860 3114971..3116308 1 NC_003155.4 hypothetical protein 3116308 1213860 SAV_2542 Streptomyces avermitilis MA-4680 hypothetical protein NP_823718.1 3114971 D 227882 CDS NP_823719.1 29829085 1213861 3116308..3117111 1 NC_003155.4 hypothetical protein 3117111 1213861 SAV_2543 Streptomyces avermitilis MA-4680 hypothetical protein NP_823719.1 3116308 D 227882 CDS NP_823720.1 29829086 1213862 3118702..3121134 1 NC_003155.4 PF01656: CobQ/CobB/MinD/ParA nucleotide binding domain; hypothetical protein 3121134 1213862 SAV_2544 Streptomyces avermitilis MA-4680 hypothetical protein NP_823720.1 3118702 D 227882 CDS NP_823721.1 29829087 1213863 complement(3121210..3122004) 1 NC_003155.4 hypothetical protein 3122004 1213863 SAV_2545 Streptomyces avermitilis MA-4680 hypothetical protein NP_823721.1 3121210 R 227882 CDS NP_823722.1 29829088 1210461 complement(3122078..3123031) 1 NC_003155.4 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 3123031 ribF 1210461 ribF Streptomyces avermitilis MA-4680 bifunctional riboflavin kinase/FMN adenylyltransferase NP_823722.1 3122078 R 227882 CDS NP_823723.1 29829089 1213864 complement(3123180..3126779) 1 NC_003155.4 hypothetical protein 3126779 1213864 SAV_2547 Streptomyces avermitilis MA-4680 hypothetical protein NP_823723.1 3123180 R 227882 CDS NP_823724.1 29829090 1210462 complement(3127064..3127969) 1 NC_003155.4 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 3127969 truB 1210462 truB Streptomyces avermitilis MA-4680 tRNA pseudouridine synthase B NP_823724.1 3127064 R 227882 CDS NP_823725.1 29829091 1210463 complement(3127966..3128439) 1 NC_003155.4 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 3128439 rbfA 1210463 rbfA Streptomyces avermitilis MA-4680 ribosome-binding factor A NP_823725.1 3127966 R 227882 CDS NP_823726.1 29829092 1213865 complement(3128474..3128767) 1 NC_003155.4 PF04456: Protein of unknown function (DUF503); hypothetical protein 3128767 1213865 SAV_2550 Streptomyces avermitilis MA-4680 hypothetical protein NP_823726.1 3128474 R 227882 CDS NP_823727.1 29829093 1210464 complement(3128920..3132060) 1 NC_003155.4 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 3132060 infB 1210464 infB Streptomyces avermitilis MA-4680 translation initiation factor IF-2 NP_823727.1 3128920 R 227882 CDS NP_823728.1 29829094 1213866 complement(3132208..3132501) 1 NC_003155.4 PF04296: Protein of unknown function (DUF448); hypothetical protein 3132501 1213866 SAV_2552 Streptomyces avermitilis MA-4680 hypothetical protein NP_823728.1 3132208 R 227882 CDS NP_823729.1 29829095 1210465 complement(3132616..3133602) 1 NC_003155.4 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 3133602 nusA 1210465 nusA Streptomyces avermitilis MA-4680 transcription elongation factor NusA NP_823729.1 3132616 R 227882 CDS NP_823730.1 29829096 1213867 complement(3133605..3134114) 1 NC_003155.4 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 3134114 1213867 SAV_2554 Streptomyces avermitilis MA-4680 hypothetical protein NP_823730.1 3133605 R 227882 CDS NP_823731.1 29829097 1213868 3134389..3135087 1 NC_003155.4 hypothetical protein 3135087 1213868 SAV_2555 Streptomyces avermitilis MA-4680 hypothetical protein NP_823731.1 3134389 D 227882 CDS NP_823732.1 29829098 1213869 3135084..3135587 1 NC_003155.4 hypothetical protein 3135587 1213869 SAV_2556 Streptomyces avermitilis MA-4680 hypothetical protein NP_823732.1 3135084 D 227882 CDS NP_823733.1 29829099 1210466 3135663..3136565 1 NC_003155.4 homology to streptomycin 6-phosphotransferase; phosphotransferase 3136565 aph2 1210466 aph2 Streptomyces avermitilis MA-4680 phosphotransferase NP_823733.1 3135663 D 227882 CDS NP_823734.1 29829100 1210467 complement(3136889..3138583) 1 NC_003155.4 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 3138583 proS1 1210467 proS1 Streptomyces avermitilis MA-4680 prolyl-tRNA synthetase NP_823734.1 3136889 R 227882 CDS NP_823735.1 29829101 1213870 complement(3138697..3139266) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 3139266 1213870 SAV_2559 Streptomyces avermitilis MA-4680 acetyltransferase NP_823735.1 3138697 R 227882 CDS NP_823736.1 29829102 1213871 complement(3139424..3140311) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 3140311 1213871 SAV_2560 Streptomyces avermitilis MA-4680 acetyltransferase NP_823736.1 3139424 R 227882 CDS NP_823737.1 29829103 1210468 complement(3140456..3141613) 1 NC_003155.4 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 3141613 ispG 1210468 ispG Streptomyces avermitilis MA-4680 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase NP_823737.1 3140456 R 227882 CDS NP_823738.1 29829104 1213872 complement(3141782..3143086) 1 NC_003155.4 PF02163: Peptidase family M50; metalloprotease 3143086 1213872 SAV_2562 Streptomyces avermitilis MA-4680 metalloprotease NP_823738.1 3141782 R 227882 CDS NP_823739.1 29829105 1210469 complement(3143083..3144267) 1 NC_003155.4 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 3144267 dxr 1210469 dxr Streptomyces avermitilis MA-4680 1-deoxy-D-xylulose 5-phosphate reductoisomerase NP_823739.1 3143083 R 227882 CDS NP_823740.1 29829106 1213873 3144529..3144978 1 NC_003155.4 PF00932: Intermediate filament tail domain; protein 3144978 1213873 SAV_2564 Streptomyces avermitilis MA-4680 protein NP_823740.1 3144529 D 227882 CDS NP_823741.1 29829107 1210470 complement(3144985..3147747) 1 NC_003155.4 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 3147747 secA2 1210470 secA2 Streptomyces avermitilis MA-4680 preprotein translocase subunit SecA NP_823741.1 3144985 R 227882 CDS NP_823742.1 29829108 1213874 complement(3147845..3148330) 1 NC_003155.4 hypothetical protein 3148330 1213874 SAV_2566 Streptomyces avermitilis MA-4680 hypothetical protein NP_823742.1 3147845 R 227882 CDS NP_823743.1 29829109 1210471 complement(3148433..3150373) 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 3150373 fadE11 1210471 fadE11 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_823743.1 3148433 R 227882 CDS NP_823744.1 29829110 1210472 complement(3150501..3151310) 1 NC_003155.4 endo-1,4-beta-glucanase 3151310 celA4 1210472 celA4 Streptomyces avermitilis MA-4680 endo-1,4-beta-glucanase NP_823744.1 3150501 R 227882 CDS NP_823745.1 29829111 1213875 3151535..3152548 1 NC_003155.4 LacI family transcriptional regulator 3152548 1213875 SAV_2569 Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_823745.1 3151535 D 227882 CDS NP_823746.1 29829112 1213876 3152878..3154806 1 NC_003155.4 PF01055: Glycosyl hydrolases family 31; glycosyl hydrolase 3154806 1213876 SAV_2570 Streptomyces avermitilis MA-4680 glycosyl hydrolase NP_823746.1 3152878 D 227882 CDS NP_823747.1 29829113 1213877 complement(3154862..3155575) 1 NC_003155.4 PF01670: Glycosyl hydrolase family 12; hypothetical protein 3155575 1213877 SAV_2571 Streptomyces avermitilis MA-4680 hypothetical protein NP_823747.1 3154862 R 227882 CDS NP_823748.1 29829114 1213878 complement(3155611..3157809) 1 NC_003155.4 hypothetical protein 3157809 1213878 SAV_2572 Streptomyces avermitilis MA-4680 hypothetical protein NP_823748.1 3155611 R 227882 CDS NP_823749.1 29829115 1210473 complement(3157806..3159785) 1 NC_003155.4 beta-galactosidase 3159785 bga6 1210473 bga6 Streptomyces avermitilis MA-4680 beta-galactosidase NP_823749.1 3157806 R 227882 CDS NP_823750.1 29829116 1213879 complement(3159785..3162004) 1 NC_003155.4 PF02012: BNR/Asp-box repeat; endo-1,4-beta-glucanase 3162004 1213879 SAV_2574 Streptomyces avermitilis MA-4680 endo-1,4-beta-glucanase NP_823750.1 3159785 R 227882 CDS NP_823751.1 29829117 1213880 complement(3162175..3163110) 1 NC_003155.4 ABC transporter permease 3163110 1213880 SAV_2575 Streptomyces avermitilis MA-4680 ABC transporter permease NP_823751.1 3162175 R 227882 CDS NP_823752.1 29829118 1213881 complement(3163107..3164192) 1 NC_003155.4 ABC transporter permease 3164192 1213881 SAV_2576 Streptomyces avermitilis MA-4680 ABC transporter permease NP_823752.1 3163107 R 227882 CDS NP_823753.1 29829119 1210474 complement(3164197..3165879) 1 NC_003155.4 multiple sugar ABC transporter substrate-binding protein 3165879 lplA 1210474 lplA Streptomyces avermitilis MA-4680 multiple sugar ABC transporter substrate-binding protein NP_823753.1 3164197 R 227882 CDS NP_823754.1 29829120 1213882 3166246..3169110 1 NC_003155.4 PF01915: Glycosyl hydrolase family 3 C terminal domain; sugar hydrolase 3169110 1213882 SAV_2578 Streptomyces avermitilis MA-4680 sugar hydrolase NP_823754.1 3166246 D 227882 CDS NP_823755.1 29829121 1213883 complement(3169298..3170743) 1 NC_003155.4 aldehyde dehydrogenase 3170743 1213883 SAV_2579 Streptomyces avermitilis MA-4680 aldehyde dehydrogenase NP_823755.1 3169298 R 227882 CDS NP_823756.1 29829122 1213884 complement(3170953..3172035) 1 NC_003155.4 frameshift; regulatory protein 3172035 1213884 SAV_2580 Streptomyces avermitilis MA-4680 regulatory protein NP_823756.1 3170953 R 227882 CDS NP_823757.1 29829123 1213885 complement(3171843..3172622) 1 NC_003155.4 frameshift; regulatory protein 3172622 1213885 SAV_2581 Streptomyces avermitilis MA-4680 regulatory protein NP_823757.1 3171843 R 227882 CDS NP_823758.1 29829124 1213886 complement(3172738..3175179) 1 NC_003155.4 ATP/GTP-binding protein 3175179 1213886 SAV_2582 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_823758.1 3172738 R 227882 CDS NP_823759.1 29829125 1210475 3175462..3176796 1 NC_003155.4 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 3176796 gabT 1210475 gabT Streptomyces avermitilis MA-4680 4-aminobutyrate aminotransferase NP_823759.1 3175462 D 227882 CDS NP_823760.1 29829126 1213887 3176974..3177798 1 NC_003155.4 PF01569: PAP2 superfamily; hypothetical protein 3177798 1213887 SAV_2584 Streptomyces avermitilis MA-4680 hypothetical protein NP_823760.1 3176974 D 227882 CDS NP_823761.1 29829127 1210476 complement(3177737..3179566) 1 NC_003155.4 chitinase B 3179566 chiB 1210476 chiB Streptomyces avermitilis MA-4680 chitinase B NP_823761.1 3177737 R 227882 CDS NP_823762.1 29829128 1213888 complement(3179635..3181170) 1 NC_003155.4 frameshift; hypothetical protein 3181170 1213888 SAV_2587 Streptomyces avermitilis MA-4680 hypothetical protein NP_823762.1 3179635 R 227882 CDS NP_823763.1 29829129 1213889 complement(3179751..3179960) 1 NC_003155.4 frameshift; hypothetical protein 3179960 1213889 SAV_2586 Streptomyces avermitilis MA-4680 hypothetical protein NP_823763.1 3179751 R 227882 CDS NP_823764.1 29829130 1213890 complement(3181199..3181999) 1 NC_003155.4 PF00528: Binding-protein-dependent transport system inner membrane component; polyamine ABC transporter permease 3181999 1213890 SAV_2588 Streptomyces avermitilis MA-4680 polyamine ABC transporter permease NP_823764.1 3181199 R 227882 CDS NP_823765.1 29829131 1213891 complement(3182000..3182944) 1 NC_003155.4 polyamine ABC transporter permease 3182944 1213891 SAV_2589 Streptomyces avermitilis MA-4680 polyamine ABC transporter permease NP_823765.1 3182000 R 227882 CDS NP_823766.1 29829132 1213892 complement(3182941..3184104) 1 NC_003155.4 polyamine ABC transporter ATP-binding protein 3184104 1213892 SAV_2590 Streptomyces avermitilis MA-4680 polyamine ABC transporter ATP-binding protein NP_823766.1 3182941 R 227882 CDS NP_823767.1 29829133 1213893 complement(3184101..3185348) 1 NC_003155.4 polyamine ABC transporter substrate-binding protein 3185348 1213893 SAV_2591 Streptomyces avermitilis MA-4680 polyamine ABC transporter substrate-binding protein NP_823767.1 3184101 R 227882 CDS NP_823768.1 29829134 1213894 complement(3185428..3186951) 1 NC_003155.4 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase 3186951 1213894 SAV_2592 Streptomyces avermitilis MA-4680 gamma-aminobutyraldehyde dehydrogenase NP_823768.1 3185428 R 227882 CDS NP_823769.1 29829135 1213895 3187135..3187722 1 NC_003155.4 hypothetical protein 3187722 1213895 SAV_2593 Streptomyces avermitilis MA-4680 hypothetical protein NP_823769.1 3187135 D 227882 CDS NP_823770.1 29829136 1213896 complement(3187745..3188071) 1 NC_003155.4 hypothetical protein 3188071 1213896 SAV_2594 Streptomyces avermitilis MA-4680 hypothetical protein NP_823770.1 3187745 R 227882 CDS NP_823771.1 29829137 1210477 3189222..3190298 1 NC_003155.4 catalyzes the formation of inosine from adenosine; adenosine deaminase 3190298 add2 1210477 add2 Streptomyces avermitilis MA-4680 adenosine deaminase NP_823771.1 3189222 D 227882 CDS NP_823772.1 29829138 1210478 3190331..3191011 1 NC_003155.4 glycerophosphoryl diester phosphodiesterase 3191011 glpQ1 1210478 glpQ1 Streptomyces avermitilis MA-4680 glycerophosphoryl diester phosphodiesterase NP_823772.1 3190331 D 227882 CDS NP_823773.1 29829139 1210479 complement(3191131..3193035) 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 3193035 sig20 1210479 sig20 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_823773.1 3191131 R 227882 CDS NP_823774.1 29829140 1213897 complement(3193078..3193662) 1 NC_003155.4 hypothetical protein 3193662 1213897 SAV_2598 Streptomyces avermitilis MA-4680 hypothetical protein NP_823774.1 3193078 R 227882 CDS NP_823775.1 29829141 1213898 3193693..3194193 1 NC_003155.4 hypothetical protein 3194193 1213898 SAV_2599 Streptomyces avermitilis MA-4680 hypothetical protein NP_823775.1 3193693 D 227882 CDS NP_823776.1 29829142 1210480 3194289..3196817 1 NC_003155.4 PF07724: ATPase family associated with various cellular activities (AAA); ATP-dependent Clp protease 3196817 clpC1 1210480 clpC1 Streptomyces avermitilis MA-4680 ATP-dependent Clp protease NP_823776.1 3194289 D 227882 CDS NP_823777.1 29829143 1213899 3197051..3197644 1 NC_003155.4 PadR-like family transcriptional regulator 3197644 1213899 SAV_2601 Streptomyces avermitilis MA-4680 PadR-like family transcriptional regulator NP_823777.1 3197051 D 227882 CDS NP_823778.1 29829144 1213900 3197875..3198312 1 NC_003155.4 PF02566: OsmC-like protein; hypothetical protein 3198312 1213900 SAV_2602 Streptomyces avermitilis MA-4680 hypothetical protein NP_823778.1 3197875 D 227882 CDS NP_823779.1 29829145 1213901 complement(3198583..3199818) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; multi-drug efflux transporter 3199818 1213901 SAV_2603 Streptomyces avermitilis MA-4680 multi-drug efflux transporter NP_823779.1 3198583 R 227882 CDS NP_823780.1 29829146 1213902 3199977..3202772 1 NC_003155.4 protein 3202772 1213902 SAV_2604 Streptomyces avermitilis MA-4680 protein NP_823780.1 3199977 D 227882 CDS NP_823781.1 29829147 1213903 3202942..3203868 1 NC_003155.4 PF03060: 2-nitropropane dioxygenase; dioxygenase 3203868 1213903 SAV_2605 Streptomyces avermitilis MA-4680 dioxygenase NP_823781.1 3202942 D 227882 CDS NP_823782.1 29829148 1213904 complement(3204071..3205114) 1 NC_003155.4 sulfate transporter 3205114 1213904 SAV_2606 Streptomyces avermitilis MA-4680 sulfate transporter NP_823782.1 3204071 R 227882 CDS NP_823783.1 29829149 1213905 3205645..3205962 1 NC_003155.4 frameshift; transposase 3205962 1213905 SAV_2607 Streptomyces avermitilis MA-4680 transposase NP_823783.1 3205645 D 227882 CDS NP_823784.1 29829150 1213906 3205662..3206138 1 NC_003155.4 frameshift; transposase 3206138 1213906 SAV_2608 Streptomyces avermitilis MA-4680 transposase NP_823784.1 3205662 D 227882 CDS NP_823785.1 29829151 1213907 complement(3206678..3207868) 1 NC_003155.4 ABC transporter substrate-binding protein 3207868 1213907 SAV_2609 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_823785.1 3206678 R 227882 CDS NP_823786.1 29829152 1213908 complement(3208119..3209558) 1 NC_003155.4 PF00171: Aldehyde dehydrogenase family; aldehyde dehydrogenase 3209558 1213908 SAV_2610 Streptomyces avermitilis MA-4680 aldehyde dehydrogenase NP_823786.1 3208119 R 227882 CDS NP_823787.1 29829153 1213909 3209748..3210248 1 NC_003155.4 transcription regulator AsnC 3210248 1213909 SAV_2611 Streptomyces avermitilis MA-4680 transcription regulator AsnC NP_823787.1 3209748 D 227882 CDS NP_823788.1 29829154 1213910 3210233..3211612 1 NC_003155.4 hypothetical protein 3211612 1213910 SAV_2612 Streptomyces avermitilis MA-4680 hypothetical protein NP_823788.1 3210233 D 227882 CDS NP_823789.1 29829155 1213911 3211871..3212608 1 NC_003155.4 ABC transporter ATP-binding protein 3212608 1213911 SAV_2613 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_823789.1 3211871 D 227882 CDS NP_823790.1 29829156 1213912 3212590..3213984 1 NC_003155.4 hypothetical protein 3213984 1213912 SAV_2614 Streptomyces avermitilis MA-4680 hypothetical protein NP_823790.1 3212590 D 227882 CDS NP_823791.1 29829157 1213913 3214075..3214482 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein 3214482 1213913 SAV_2615 Streptomyces avermitilis MA-4680 hypothetical protein NP_823791.1 3214075 D 227882 CDS NP_823792.1 29829158 1213914 3214509..3215627 1 NC_003155.4 PF03641: Possible lysine decarboxylase; hypothetical protein 3215627 1213914 SAV_2616 Streptomyces avermitilis MA-4680 hypothetical protein NP_823792.1 3214509 D 227882 CDS NP_823793.1 29829159 1213915 3215775..3216449 1 NC_003155.4 hypothetical protein 3216449 1213915 SAV_2617 Streptomyces avermitilis MA-4680 hypothetical protein NP_823793.1 3215775 D 227882 CDS NP_823794.1 29829160 1213916 complement(3216570..3217607) 1 NC_003155.4 ABC transporter ATP-binding protein 3217607 1213916 SAV_2618 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_823794.1 3216570 R 227882 CDS NP_823795.1 29829161 1213917 complement(3217608..3219308) 1 NC_003155.4 hypothetical protein 3219308 1213917 SAV_2619 Streptomyces avermitilis MA-4680 hypothetical protein NP_823795.1 3217608 R 227882 CDS NP_823796.1 29829162 1213918 complement(3219272..3220357) 1 NC_003155.4 ABC transporter substrate-binding protein 3220357 1213918 SAV_2620 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_823796.1 3219272 R 227882 CDS NP_823797.1 29829163 1213919 complement(3220568..3221674) 1 NC_003155.4 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 3221674 1213919 SAV_2621 Streptomyces avermitilis MA-4680 ribosomal RNA large subunit methyltransferase N NP_823797.1 3220568 R 227882 CDS NP_823798.1 29829164 1213920 complement(3221960..3222370) 1 NC_003155.4 hypothetical protein 3222370 1213920 SAV_2622 Streptomyces avermitilis MA-4680 hypothetical protein NP_823798.1 3221960 R 227882 CDS NP_823799.1 29829165 1210481 complement(3222628..3223806) 1 NC_003155.4 phosphatidate cytidylyltransferase 3223806 cdsA 1210481 cdsA Streptomyces avermitilis MA-4680 phosphatidate cytidylyltransferase NP_823799.1 3222628 R 227882 CDS NP_823800.1 29829166 1210482 complement(3223806..3224363) 1 NC_003155.4 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 3224363 frr 1210482 frr Streptomyces avermitilis MA-4680 ribosome recycling factor NP_823800.1 3223806 R 227882 CDS NP_823801.1 29829167 1210483 complement(3224517..3225275) 1 NC_003155.4 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 3225275 pyrH 1210483 pyrH Streptomyces avermitilis MA-4680 uridylate kinase NP_823801.1 3224517 R 227882 CDS NP_823802.1 29829168 1210484 complement(3225476..3226312) 1 NC_003155.4 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 3226312 tsf 1210484 tsf Streptomyces avermitilis MA-4680 elongation factor Ts NP_823802.1 3225476 R 227882 CDS NP_823803.1 29829169 1210485 complement(3226409..3227335) 1 NC_003155.4 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 3227335 rpsB 1210485 rpsB Streptomyces avermitilis MA-4680 30S ribosomal protein S2 NP_823803.1 3226409 R 227882 CDS NP_823804.1 29829170 1213921 3227598..3228296 1 NC_003155.4 PF01551: Peptidase family M23; peptidase 3228296 1213921 SAV_2628 Streptomyces avermitilis MA-4680 peptidase NP_823804.1 3227598 D 227882 CDS NP_823805.1 29829171 1213922 complement(3228411..3228950) 1 NC_003155.4 TetR family transcriptional regulator 3228950 1213922 SAV_2629 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_823805.1 3228411 R 227882 CDS NP_823806.1 29829172 1210486 complement(3229155..3229997) 1 NC_003155.4 involved in the initiation of sporulation and glycogen biosynthesis; RNA polymerase sigma factor WhiG 3229997 whiG 1210486 whiG Streptomyces avermitilis MA-4680 RNA polymerase sigma factor WhiG NP_823806.1 3229155 R 227882 CDS NP_823807.1 29829173 1213923 complement(3230270..3231415) 1 NC_003155.4 DNA processing Smf-family protein 3231415 1213923 SAV_2631 Streptomyces avermitilis MA-4680 DNA processing Smf-family protein NP_823807.1 3230270 R 227882 CDS NP_823808.1 29829174 1213924 complement(3231412..3233037) 1 NC_003155.4 magnesium chelatase 3233037 1213924 SAV_2632 Streptomyces avermitilis MA-4680 magnesium chelatase NP_823808.1 3231412 R 227882 CDS NP_823809.1 29829175 1213925 complement(3233037..3233579) 1 NC_003155.4 PF02021: Uncharacterised protein family UPF0102; hypothetical protein 3233579 1213925 SAV_2633 Streptomyces avermitilis MA-4680 hypothetical protein NP_823809.1 3233037 R 227882 CDS NP_823810.1 29829176 1213926 complement(3233591..3233899) 1 NC_003155.4 hypothetical protein 3233899 1213926 SAV_2634 Streptomyces avermitilis MA-4680 hypothetical protein NP_823810.1 3233591 R 227882 CDS NP_823811.1 29829177 1213927 complement(3234017..3234544) 1 NC_003155.4 PF00293: NUDIX domain; MutT/NUDIX family hydrolase 3234544 1213927 SAV_2635 Streptomyces avermitilis MA-4680 MutT/NUDIX family hydrolase NP_823811.1 3234017 R 227882 CDS NP_823812.1 29829178 1213928 complement(3234534..3235277) 1 NC_003155.4 PF00717: Peptidase S24-like; signal peptidase 3235277 1213928 SAV_2636 Streptomyces avermitilis MA-4680 signal peptidase NP_823812.1 3234534 R 227882 CDS NP_823813.1 29829179 1213929 complement(3235357..3236232) 1 NC_003155.4 PF00717: Peptidase S24-like; signal peptidase 3236232 1213929 SAV_2637 Streptomyces avermitilis MA-4680 signal peptidase NP_823813.1 3235357 R 227882 CDS NP_823814.1 29829180 1213930 complement(3236204..3237286) 1 NC_003155.4 PF00717: Peptidase S24-like; signal peptidase 3237286 1213930 SAV_2638 Streptomyces avermitilis MA-4680 signal peptidase NP_823814.1 3236204 R 227882 CDS NP_823815.1 29829181 1213931 complement(3237279..3237995) 1 NC_003155.4 PF00717: Peptidase S24-like; signal peptidase 3237995 1213931 SAV_2639 Streptomyces avermitilis MA-4680 signal peptidase NP_823815.1 3237279 R 227882 CDS NP_823816.1 29829182 1210487 complement(3238041..3238391) 1 NC_003155.4 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 3238391 rplS 1210487 rplS Streptomyces avermitilis MA-4680 50S ribosomal protein L19 NP_823816.1 3238041 R 227882 CDS NP_823817.1 29829183 1210488 complement(3238527..3239375) 1 NC_003155.4 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 3239375 trmD 1210488 trmD Streptomyces avermitilis MA-4680 tRNA (guanine-N(1)-)-methyltransferase NP_823817.1 3238527 R 227882 CDS NP_823818.1 29829184 1210489 complement(3239375..3239935) 1 NC_003155.4 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 3239935 rimM 1210489 rimM Streptomyces avermitilis MA-4680 16S rRNA-processing protein RimM NP_823818.1 3239375 R 227882 CDS NP_823819.1 29829185 1213932 complement(3240044..3240283) 1 NC_003155.4 hypothetical protein 3240283 1213932 SAV_2643 Streptomyces avermitilis MA-4680 hypothetical protein NP_823819.1 3240044 R 227882 CDS NP_823820.1 29829186 1210490 complement(3240286..3240714) 1 NC_003155.4 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 3240714 rpsP 1210490 rpsP Streptomyces avermitilis MA-4680 30S ribosomal protein S16 NP_823820.1 3240286 R 227882 CDS NP_823821.1 29829187 1213933 complement(3240997..3241593) 1 NC_003155.4 hypothetical protein 3241593 1213933 SAV_2645 Streptomyces avermitilis MA-4680 hypothetical protein NP_823821.1 3240997 R 227882 CDS NP_823822.1 29829188 1210491 complement(3241855..3243270) 1 NC_003155.4 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 3243270 proS2 1210491 proS2 Streptomyces avermitilis MA-4680 prolyl-tRNA synthetase NP_823822.1 3241855 R 227882 CDS NP_823823.1 29829189 1213934 3243503..3244366 1 NC_003155.4 hypothetical protein 3244366 1213934 SAV_2647 Streptomyces avermitilis MA-4680 hypothetical protein NP_823823.1 3243503 D 227882 CDS NP_823824.1 29829190 1210492 complement(3244452..3246002) 1 NC_003155.4 signal recognition particle 3246002 ffh 1210492 ffh Streptomyces avermitilis MA-4680 signal recognition particle NP_823824.1 3244452 R 227882 CDS NP_823825.2 57833860 1210493 complement(3246143..3248602) 1 NC_003155.4 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; also involved in adenylylating and deadelnylyating GlnK; PII uridylyl-transferase 3248602 glnD 1210493 glnD Streptomyces avermitilis MA-4680 PII uridylyl-transferase NP_823825.2 3246143 R 227882 CDS NP_823826.1 29829192 1210494 complement(3248625..3248963) 1 NC_003155.4 regulatory protein for glutamine synthetase; glnB-homolog; nitrogen regulatory protein P-II 3248963 glnB1 1210494 glnB1 Streptomyces avermitilis MA-4680 nitrogen regulatory protein P-II NP_823826.1 3248625 R 227882 CDS NP_823827.1 29829193 1213935 complement(3248960..3250300) 1 NC_003155.4 ammonium transporter 3250300 amtB1 1213935 amtB1 Streptomyces avermitilis MA-4680 ammonium transporter NP_823827.1 3248960 R 227882 CDS NP_823828.1 29829194 1213936 complement(3250639..3252114) 1 NC_003155.4 regulatory protein 3252114 1213936 SAV_2652 Streptomyces avermitilis MA-4680 regulatory protein NP_823828.1 3250639 R 227882 CDS NP_823829.1 29829195 1213937 3252563..3253225 1 NC_003155.4 hypothetical protein 3253225 1213937 SAV_2653 Streptomyces avermitilis MA-4680 hypothetical protein NP_823829.1 3252563 D 227882 CDS NP_823830.1 29829196 1210495 complement(3253315..3254544) 1 NC_003155.4 signal recognition particle 3254544 ftsY 1210495 ftsY Streptomyces avermitilis MA-4680 signal recognition particle NP_823830.1 3253315 R 227882 CDS NP_823831.1 29829197 1213938 3254633..3256105 1 NC_003155.4 allantoin permease 3256105 1213938 SAV_2655 Streptomyces avermitilis MA-4680 allantoin permease NP_823831.1 3254633 D 227882 CDS NP_823832.1 29829198 1213939 3256152..3257132 1 NC_003155.4 PF00296: Luciferase-like monooxygenase; hypothetical protein 3257132 1213939 SAV_2656 Streptomyces avermitilis MA-4680 hypothetical protein NP_823832.1 3256152 D 227882 CDS NP_823833.1 29829199 1210496 complement(3257219..3258631) 1 NC_003155.4 L-arabinose permease 3258631 araE 1210496 araE Streptomyces avermitilis MA-4680 L-arabinose permease NP_823833.1 3257219 R 227882 CDS NP_823834.1 29829200 1210497 complement(3258894..3262502) 1 NC_003155.4 PF02483: SMC family, C-terminal domain; chromosome segregation protein 3262502 smc 1210497 smc Streptomyces avermitilis MA-4680 chromosome segregation protein NP_823834.1 3258894 R 227882 CDS NP_823835.1 29829201 1210498 complement(3263295..3263576) 1 NC_003155.4 catalyzes the hydrolysis of acylphosphate; acylphosphatase 3263576 acyP 1210498 acyP Streptomyces avermitilis MA-4680 acylphosphatase NP_823835.1 3263295 R 227882 CDS NP_823836.1 29829202 1213940 3263727..3264662 1 NC_003155.4 PF00188: SCP-like extracellular protein; hypothetical protein 3264662 1213940 SAV_2660 Streptomyces avermitilis MA-4680 hypothetical protein NP_823836.1 3263727 D 227882 CDS NP_823837.1 29829203 1213941 complement(3264841..3265464) 1 NC_003155.4 PF00258: Flavodoxin; hypothetical protein 3265464 1213941 SAV_2661 Streptomyces avermitilis MA-4680 hypothetical protein NP_823837.1 3264841 R 227882 CDS NP_823838.1 29829204 1213942 3265560..3265973 1 NC_003155.4 PF01638: Transcriptional regulator; transcriptional regulator 3265973 1213942 SAV_2662 Streptomyces avermitilis MA-4680 transcriptional regulator NP_823838.1 3265560 D 227882 CDS NP_823839.1 29829205 1213943 complement(3265995..3267308) 1 NC_003155.4 PF00144: Beta-lactamase; beta-lactamase 3267308 1213943 SAV_2663 Streptomyces avermitilis MA-4680 beta-lactamase NP_823839.1 3265995 R 227882 CDS NP_823840.1 29829206 1210499 complement(3267410..3268270) 1 NC_003155.4 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 3268270 mutM1 1210499 mutM1 Streptomyces avermitilis MA-4680 formamidopyrimidine-DNA glycosylase NP_823840.1 3267410 R 227882 CDS NP_823841.1 29829207 1210500 complement(3268331..3269161) 1 NC_003155.4 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 3269161 rnc 1210500 rnc Streptomyces avermitilis MA-4680 ribonuclease III NP_823841.1 3268331 R 227882 CDS NP_823842.1 29829208 1210501 complement(3269181..3269354) 1 NC_003155.4 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 3269354 rpmF 1210501 rpmF Streptomyces avermitilis MA-4680 50S ribosomal protein L32 NP_823842.1 3269181 R 227882 CDS NP_823843.1 29829209 1213944 complement(3269357..3270010) 1 NC_003155.4 PF02620: Uncharacterized ACR, COG1399; hypothetical protein 3270010 1213944 SAV_2667 Streptomyces avermitilis MA-4680 hypothetical protein NP_823843.1 3269357 R 227882 CDS NP_823844.1 29829210 1213945 complement(3270151..3271242) 1 NC_003155.4 PF05227: CHASE3 domain; hypothetical protein 3271242 1213945 SAV_2668 Streptomyces avermitilis MA-4680 hypothetical protein NP_823844.1 3270151 R 227882 CDS NP_823845.1 29829211 1210502 complement(3271392..3271871) 1 NC_003155.4 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 3271871 coaD 1210502 coaD Streptomyces avermitilis MA-4680 phosphopantetheine adenylyltransferase NP_823845.1 3271392 R 227882 CDS NP_823846.1 29829212 1213946 complement(3271898..3272485) 1 NC_003155.4 RNA methylase 3272485 1213946 SAV_2670 Streptomyces avermitilis MA-4680 RNA methylase NP_823846.1 3271898 R 227882 CDS NP_823847.1 29829213 1210503 complement(3272525..3275752) 1 NC_003155.4 PF00271: Helicase conserved C-terminal domain; ATP-dependent DNA helicase 3275752 recG 1210503 recG Streptomyces avermitilis MA-4680 ATP-dependent DNA helicase NP_823847.1 3272525 R 227882 CDS NP_823848.1 29829214 1210504 3276139..3277977 1 NC_003155.4 HSP90 family protein 3277977 htpG 1210504 htpG Streptomyces avermitilis MA-4680 HSP90 family protein NP_823848.1 3276139 D 227882 CDS NP_823849.1 29829215 1213947 3277935..3280910 1 NC_003155.4 PF04012: PspA/IM30 family; hypothetical protein 3280910 1213947 SAV_2673 Streptomyces avermitilis MA-4680 hypothetical protein NP_823849.1 3277935 D 227882 CDS NP_823850.1 29829216 1210505 complement(3281061..3282776) 1 NC_003155.4 dihydroxyacetone kinase 3282776 dak3 1210505 dak3 Streptomyces avermitilis MA-4680 dihydroxyacetone kinase NP_823850.1 3281061 R 227882 CDS NP_823851.1 29829217 1210506 3283164..3283349 1 NC_003155.4 required for 70S ribosome assembly; 50S ribosomal protein L28 3283349 rpmB 1210506 rpmB Streptomyces avermitilis MA-4680 50S ribosomal protein L28 NP_823851.1 3283164 D 227882 CDS NP_823852.1 29829218 1210507 complement(3283489..3284451) 1 NC_003155.4 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 3284451 thiL 1210507 thiL Streptomyces avermitilis MA-4680 thiamine monophosphate kinase NP_823852.1 3283489 R 227882 CDS NP_823853.1 29829219 1213948 3284697..3284930 1 NC_003155.4 PF01037: AsnC family; hypothetical protein 3284930 1213948 SAV_2677 Streptomyces avermitilis MA-4680 hypothetical protein NP_823853.1 3284697 D 227882 CDS NP_823854.1 29829220 1213949 3284951..3285442 1 NC_003155.4 hypothetical protein 3285442 1213949 SAV_2678 Streptomyces avermitilis MA-4680 hypothetical protein NP_823854.1 3284951 D 227882 CDS NP_823855.1 29829221 1210508 complement(3285458..3286615) 1 NC_003155.4 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 3286615 ddl 1210508 ddl Streptomyces avermitilis MA-4680 D-alanyl-alanine synthetase A NP_823855.1 3285458 R 227882 CDS NP_823856.1 29829222 1210509 complement(3286753..3287763) 1 NC_003155.4 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 3287763 gpsA 1210509 gpsA Streptomyces avermitilis MA-4680 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase NP_823856.1 3286753 R 227882 CDS NP_823857.1 29829223 1210510 complement(3287760..3288560) 1 NC_003155.4 1-acylglycerol-3-phosphate O-acyltransferase 3288560 plsC2 1210510 plsC2 Streptomyces avermitilis MA-4680 1-acylglycerol-3-phosphate O-acyltransferase NP_823857.1 3287760 R 227882 CDS NP_823858.1 29829224 1213950 3288705..3289355 1 NC_003155.4 PF01983: Protein of unknown function DUF121; hypothetical protein 3289355 1213950 SAV_2682 Streptomyces avermitilis MA-4680 hypothetical protein NP_823858.1 3288705 D 227882 CDS NP_823859.1 29829225 1213951 3289365..3289568 1 NC_003155.4 hypothetical protein 3289568 1213951 SAV_2683 Streptomyces avermitilis MA-4680 hypothetical protein NP_823859.1 3289365 D 227882 CDS NP_823860.1 29829226 1213952 complement(3289655..3290308) 1 NC_003155.4 PF00216: Bacterial DNA-binding protein; histone-like DNA-binding protein 3290308 1213952 SAV_2684 Streptomyces avermitilis MA-4680 histone-like DNA-binding protein NP_823860.1 3289655 R 227882 CDS NP_823861.1 29829227 1210511 complement(3290964..3291557) 1 NC_003155.4 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 3291557 leuD 1210511 leuD Streptomyces avermitilis MA-4680 isopropylmalate isomerase small subunit NP_823861.1 3290964 R 227882 CDS NP_823862.1 29829228 1210512 complement(3291564..3292997) 1 NC_003155.4 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 3292997 leuC 1210512 leuC Streptomyces avermitilis MA-4680 isopropylmalate isomerase large subunit NP_823862.1 3291564 R 227882 CDS NP_823863.1 29829229 1213953 3293189..3293905 1 NC_003155.4 IclR family transcriptional regulator 3293905 1213953 SAV_2687 Streptomyces avermitilis MA-4680 IclR family transcriptional regulator NP_823863.1 3293189 D 227882 CDS NP_823864.1 29829230 1213954 complement(3293979..3294476) 1 NC_003155.4 hypothetical protein 3294476 1213954 SAV_2688 Streptomyces avermitilis MA-4680 hypothetical protein NP_823864.1 3293979 R 227882 CDS NP_823865.1 29829231 1213955 3294558..3295202 1 NC_003155.4 transcriptional regulator 3295202 1213955 SAV_2689 Streptomyces avermitilis MA-4680 transcriptional regulator NP_823865.1 3294558 D 227882 CDS NP_823866.1 29829232 1213956 complement(3295851..3296987) 1 NC_003155.4 PF00702: haloacid dehalogenase-like hydrolase; hydrolase 3296987 1213956 SAV_2690 Streptomyces avermitilis MA-4680 hydrolase NP_823866.1 3295851 R 227882 CDS NP_823867.1 29829233 1210518 complement(3297120..3298634) 1 NC_003155.4 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 3298634 gltX 1210518 gltX Streptomyces avermitilis MA-4680 glutamyl-tRNA synthetase NP_823867.1 3297120 R 227882 CDS NP_823868.1 29829234 1213957 complement(3298627..3299403) 1 NC_003155.4 PF01557: Fumarylacetoacetate (FAA) hydrolase family; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase 3299403 1213957 SAV_2692 Streptomyces avermitilis MA-4680 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase NP_823868.1 3298627 R 227882 CDS NP_823869.1 29829235 1213958 complement(3299569..3299742) 1 NC_003155.4 hypothetical protein 3299742 1213958 SAV_2693 Streptomyces avermitilis MA-4680 hypothetical protein NP_823869.1 3299569 R 227882 CDS NP_823870.1 29829236 1210519 3300359..3304195 1 NC_003155.4 multi-component regulatory system-6; sensor-like histidine kinase 3304195 cvnA6 1210519 cvnA6 Streptomyces avermitilis MA-4680 sensor-like histidine kinase NP_823870.1 3300359 D 227882 CDS NP_823871.1 29829237 1210520 3304205..3304618 1 NC_003155.4 multi-component regulatory system-6, PF03259: Roadblock/LC7 domain; hypothetical protein 3304618 cvnB6 1210520 cvnB6 Streptomyces avermitilis MA-4680 hypothetical protein NP_823871.1 3304205 D 227882 CDS NP_823872.1 29829238 1210521 3304730..3305128 1 NC_003155.4 multi-component regulatory system-6, PF05331: Protein of unknown function (DUF742); hypothetical protein 3305128 cvnC6 1210521 cvnC6 Streptomyces avermitilis MA-4680 hypothetical protein NP_823872.1 3304730 D 227882 CDS NP_823873.1 29829239 1210522 3305109..3305687 1 NC_003155.4 multi-component regulatory system-6; ATP/GTP-binding protein 3305687 cvnD6 1210522 cvnD6 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_823873.1 3305109 D 227882 CDS NP_823874.1 29829240 1210523 3306085..3309330 1 NC_003155.4 multi-component regulatory system-7; sensor-like histidine kinase 3309330 cvnA7 1210523 cvnA7 Streptomyces avermitilis MA-4680 sensor-like histidine kinase NP_823874.1 3306085 D 227882 CDS NP_823875.1 29829241 1210524 3309341..3309754 1 NC_003155.4 multi-component regulatory system-7, PF03259: Roadblock/LC7 domain; hypothetical protein 3309754 cvnB7 1210524 cvnB7 Streptomyces avermitilis MA-4680 hypothetical protein NP_823875.1 3309341 D 227882 CDS NP_823876.1 29829242 1210525 3309851..3310435 1 NC_003155.4 multi-component regulatory system-7, PF05331: Protein of unknown function (DUF742); hypothetical protein 3310435 cvnC7 1210525 cvnC7 Streptomyces avermitilis MA-4680 hypothetical protein NP_823876.1 3309851 D 227882 CDS NP_823877.1 29829243 1210526 3310473..3310997 1 NC_003155.4 multi-component regulatory system-7; ATP/GTP-binding protein 3310997 cvnD7 1210526 cvnD7 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_823877.1 3310473 D 227882 CDS NP_823878.1 29829244 1213959 complement(3311416..3311610) 1 NC_003155.4 hypothetical protein 3311610 1213959 SAV_2702 Streptomyces avermitilis MA-4680 hypothetical protein NP_823878.1 3311416 R 227882 CDS NP_823879.1 29829245 1210527 complement(3311668..3313263) 1 NC_003155.4 PF01039: Carboxyl transferase domain; methylmalonyl-CoA decarboxylase alpha subunit 3313263 mmdA2 1210527 mmdA2 Streptomyces avermitilis MA-4680 methylmalonyl-CoA decarboxylase alpha subunit NP_823879.1 3311668 R 227882 CDS NP_823880.1 29829246 1213960 complement(3313418..3315745) 1 NC_003155.4 PF02278: Polysaccharide lyase family 8, super-sandwich domain; polysaccharide lyase (hyaluronidase) 3315745 1213960 SAV_2704 Streptomyces avermitilis MA-4680 polysaccharide lyase (hyaluronidase) NP_823880.1 3313418 R 227882 CDS NP_823881.1 29829247 1213961 complement(3315813..3316322) 1 NC_003155.4 hypothetical protein 3316322 1213961 SAV_2705 Streptomyces avermitilis MA-4680 hypothetical protein NP_823881.1 3315813 R 227882 CDS NP_823882.1 29829248 1213962 3316560..3317180 1 NC_003155.4 PF04264: YceI like family; hypothetical protein 3317180 1213962 SAV_2706 Streptomyces avermitilis MA-4680 hypothetical protein NP_823882.1 3316560 D 227882 CDS NP_823883.1 29829249 1213963 complement(3317290..3318660) 1 NC_003155.4 hypothetical protein 3318660 1213963 SAV_2707 Streptomyces avermitilis MA-4680 hypothetical protein NP_823883.1 3317290 R 227882 CDS NP_823884.1 29829250 1213964 complement(3318766..3321801) 1 NC_003155.4 PF00933: Glycosyl hydrolase family 3 N terminal domain; glycosyl hydrolase 3321801 1213964 SAV_2708 Streptomyces avermitilis MA-4680 glycosyl hydrolase NP_823884.1 3318766 R 227882 CDS NP_823885.1 29829251 1213965 3321963..3323906 1 NC_003155.4 PF00652: QXW lectin repeat; glycosyl hydrolase 3323906 1213965 SAV_2709 Streptomyces avermitilis MA-4680 glycosyl hydrolase NP_823885.1 3321963 D 227882 CDS NP_823886.1 29829252 1210528 complement(3323914..3325518) 1 NC_003155.4 catalyzes the formation of 2-isopropylmalate from 1-methyl-2-oxobutanoate and acetyl-CoA; putative alpha-isopropylmalate/homocitrate synthase family transferase 3325518 leuA1 1210528 leuA1 Streptomyces avermitilis MA-4680 putative alpha-isopropylmalate/homocitrate synthase family transferase NP_823886.1 3323914 R 227882 CDS NP_823887.1 29829253 1213966 complement(3325807..3327138) 1 NC_003155.4 PF00083: Sugar (and other) transporter; transporter 3327138 1213966 SAV_2711 Streptomyces avermitilis MA-4680 transporter NP_823887.1 3325807 R 227882 CDS NP_823888.1 29829254 1213967 complement(3327202..3328545) 1 NC_003155.4 PF07676: WD40-like Beta Propeller Repeat; hypothetical protein 3328545 1213967 SAV_2712 Streptomyces avermitilis MA-4680 hypothetical protein NP_823888.1 3327202 R 227882 CDS NP_823889.1 29829255 1213968 complement(3328981..3329601) 1 NC_003155.4 TetR family transcriptional regulator 3329601 1213968 SAV_2713 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_823889.1 3328981 R 227882 CDS NP_823890.1 29829256 1210529 complement(3329613..3330653) 1 NC_003155.4 agmatine deiminase 3330653 aguA 1210529 aguA Streptomyces avermitilis MA-4680 agmatine deiminase NP_823890.1 3329613 R 227882 CDS NP_823891.1 29829257 1210530 complement(3330663..3332333) 1 NC_003155.4 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 3332333 ureC 1210530 ureC Streptomyces avermitilis MA-4680 urease subunit alpha NP_823891.1 3330663 R 227882 CDS NP_823892.1 29829258 1210531 complement(3332330..3333013) 1 NC_003155.4 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; bifunctional urease subunit gamma/beta 3333013 ureAB 1210531 ureAB Streptomyces avermitilis MA-4680 bifunctional urease subunit gamma/beta NP_823892.1 3332330 R 227882 CDS NP_823893.1 29829259 1210532 complement(3333251..3334339) 1 NC_003155.4 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 3334339 ilvE 1210532 ilvE Streptomyces avermitilis MA-4680 branched-chain amino acid aminotransferase NP_823893.1 3333251 R 227882 CDS NP_823894.1 29829260 1210533 complement(3334606..3335649) 1 NC_003155.4 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 3335649 leuB 1210533 leuB Streptomyces avermitilis MA-4680 3-isopropylmalate dehydrogenase NP_823894.1 3334606 R 227882 CDS NP_823895.1 29829261 1213969 3335713..3337362 1 NC_003155.4 phosphoesterase 3337362 ppe1 1213969 ppe1 Streptomyces avermitilis MA-4680 phosphoesterase NP_823895.1 3335713 D 227882 CDS NP_823896.1 29829262 1213970 complement(3337468..3337599) 1 NC_003155.4 hypothetical protein 3337599 1213970 SAV_2720 Streptomyces avermitilis MA-4680 hypothetical protein NP_823896.1 3337468 R 227882 CDS NP_823897.1 29829263 1210534 complement(3338018..3338587) 1 NC_003155.4 aminoglycoside 2'-N-acetyltransferase 3338587 aac1 1210534 aac1 Streptomyces avermitilis MA-4680 aminoglycoside 2'-N-acetyltransferase NP_823897.1 3338018 R 227882 CDS NP_823898.1 29829264 1213971 3338680..3339549 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 3339549 1213971 SAV_2722 Streptomyces avermitilis MA-4680 hydrolase NP_823898.1 3338680 D 227882 CDS NP_823899.1 29829265 1213972 complement(3339557..3341188) 1 NC_003155.4 delta-1-pyrroline-5-carboxylate dehydrogenase 3341188 rocA 1213972 rocA Streptomyces avermitilis MA-4680 delta-1-pyrroline-5-carboxylate dehydrogenase NP_823899.1 3339557 R 227882 CDS NP_823900.1 29829266 1210535 complement(3341334..3342260) 1 NC_003155.4 proline dehydrogenase 3342260 putA 1210535 putA Streptomyces avermitilis MA-4680 proline dehydrogenase NP_823900.1 3341334 R 227882 CDS NP_823901.1 29829267 1213973 3342426..3343625 1 NC_003155.4 transcriptional regulator 3343625 1213973 SAV_2725 Streptomyces avermitilis MA-4680 transcriptional regulator NP_823901.1 3342426 D 227882 CDS NP_823902.1 29829268 1213974 complement(3343682..3345178) 1 NC_003155.4 hypothetical protein 3345178 1213974 SAV_2726 Streptomyces avermitilis MA-4680 hypothetical protein NP_823902.1 3343682 R 227882 CDS NP_823903.1 29829269 1213975 complement(3345291..3345881) 1 NC_003155.4 TetR family transcriptional regulator 3345881 1213975 SAV_2727 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_823903.1 3345291 R 227882 CDS NP_823904.1 29829270 1213976 3346066..3347538 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 3347538 1213976 SAV_2728 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_823904.1 3346066 D 227882 CDS NP_823905.1 29829271 1213977 3347780..3350794 1 NC_003155.4 LuxR family transcriptional regulator 3350794 1213977 SAV_2729 Streptomyces avermitilis MA-4680 LuxR family transcriptional regulator NP_823905.1 3347780 D 227882 CDS NP_823906.1 29829272 1210536 complement(3350907..3352496) 1 NC_003155.4 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 3352496 serA 1210536 serA Streptomyces avermitilis MA-4680 D-3-phosphoglycerate dehydrogenase NP_823906.1 3350907 R 227882 CDS NP_823907.1 29829273 1210537 complement(3352764..3353765) 1 NC_003155.4 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 3353765 ilvC 1210537 ilvC Streptomyces avermitilis MA-4680 ketol-acid reductoisomerase NP_823907.1 3352764 R 227882 CDS NP_823908.1 29829274 1210538 complement(3353885..3354412) 1 NC_003155.4 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 3354412 ilvH 1210538 ilvH Streptomyces avermitilis MA-4680 acetolactate synthase 3 regulatory subunit NP_823908.1 3353885 R 227882 CDS NP_823909.1 29829275 1210539 complement(3354433..3356283) 1 NC_003155.4 acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; acetolactate synthase 1 catalytic subunit 3356283 ilvB1 1210539 ilvB1 Streptomyces avermitilis MA-4680 acetolactate synthase 1 catalytic subunit NP_823909.1 3354433 R 227882 CDS NP_823910.1 29829276 1213978 complement(3356515..3359652) 1 NC_003155.4 PF00563: EAL domain; integral membrane phosphodiesterase 3359652 1213978 SAV_2734 Streptomyces avermitilis MA-4680 integral membrane phosphodiesterase NP_823910.1 3356515 R 227882 CDS NP_823911.1 29829277 1213979 complement(3359884..3360825) 1 NC_003155.4 PF02826: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; dehydrogenase 3360825 1213979 SAV_2735 Streptomyces avermitilis MA-4680 dehydrogenase NP_823911.1 3359884 R 227882 CDS NP_823912.1 29829278 1213980 3360967..3361899 1 NC_003155.4 PF00248: Aldo/keto reductase family; oxidoreductase 3361899 1213980 SAV_2736 Streptomyces avermitilis MA-4680 oxidoreductase NP_823912.1 3360967 D 227882 CDS NP_823913.1 29829279 1213981 3362169..3363332 1 NC_003155.4 PF05481: Mycobacterium 19 kDa lipoprotein antigen; oxidoreductase 3363332 1213981 SAV_2737 Streptomyces avermitilis MA-4680 oxidoreductase NP_823913.1 3362169 D 227882 CDS NP_823914.1 29829280 1213982 complement(3363349..3363621) 1 NC_003155.4 hypothetical protein 3363621 1213982 SAV_2738 Streptomyces avermitilis MA-4680 hypothetical protein NP_823914.1 3363349 R 227882 CDS NP_823915.1 29829281 1213983 complement(3363618..3367091) 1 NC_003155.4 LuxR family transcriptional regulator 3367091 1213983 SAV_2739 Streptomyces avermitilis MA-4680 LuxR family transcriptional regulator NP_823915.1 3363618 R 227882 CDS NP_823916.1 29829282 1213984 complement(3367088..3367390) 1 NC_003155.4 hypothetical protein 3367390 1213984 SAV_2740 Streptomyces avermitilis MA-4680 hypothetical protein NP_823916.1 3367088 R 227882 CDS NP_823917.1 29829283 1213985 complement(3367493..3368104) 1 NC_003155.4 hypothetical protein 3368104 1213985 SAV_2741 Streptomyces avermitilis MA-4680 hypothetical protein NP_823917.1 3367493 R 227882 CDS NP_823918.1 29829284 1213986 complement(3368140..3368715) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 3368715 1213986 SAV_2742 Streptomyces avermitilis MA-4680 acetyltransferase NP_823918.1 3368140 R 227882 CDS NP_823919.1 29829285 1210540 complement(3369059..3370576) 1 NC_003155.4 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 3370576 gatB 1210540 gatB Streptomyces avermitilis MA-4680 aspartyl/glutamyl-tRNA amidotransferase subunit B NP_823919.1 3369059 R 227882 CDS NP_823920.1 29829286 1213987 complement(3370593..3370835) 1 NC_003155.4 hypothetical protein 3370835 1213987 SAV_2744 Streptomyces avermitilis MA-4680 hypothetical protein NP_823920.1 3370593 R 227882 CDS NP_823921.1 29829287 1210541 complement(3370832..3372337) 1 NC_003155.4 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 3372337 gatA 1210541 gatA Streptomyces avermitilis MA-4680 aspartyl/glutamyl-tRNA amidotransferase subunit A NP_823921.1 3370832 R 227882 CDS NP_823922.1 29829288 1210542 complement(3372343..3372639) 1 NC_003155.4 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 3372639 gatC 1210542 gatC Streptomyces avermitilis MA-4680 aspartyl/glutamyl-tRNA amidotransferase subunit C NP_823922.1 3372343 R 227882 CDS NP_823923.1 29829289 1213988 complement(3372950..3375286) 1 NC_003155.4 PF00563: EAL domain; phosphodiesterase 3375286 1213988 SAV_2747 Streptomyces avermitilis MA-4680 phosphodiesterase NP_823923.1 3372950 R 227882 CDS NP_823924.1 29829290 1210543 complement(3375523..3377715) 1 NC_003155.4 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 3377715 ligA 1210543 ligA Streptomyces avermitilis MA-4680 NAD-dependent DNA ligase LigA NP_823924.1 3375523 R 227882 CDS NP_823925.1 29829291 1213989 complement(3377731..3378738) 1 NC_003155.4 PF01717: Methionine synthase, vitamin-B12 independent; hypothetical protein 3378738 1213989 SAV_2749 Streptomyces avermitilis MA-4680 hypothetical protein NP_823925.1 3377731 R 227882 CDS NP_823926.1 29829292 1213990 complement(3378845..3379543) 1 NC_003155.4 PF00106: short chain dehydrogenase; short chain dehydrogenase 3379543 1213990 SAV_2750 Streptomyces avermitilis MA-4680 short chain dehydrogenase NP_823926.1 3378845 R 227882 CDS NP_823927.1 29829293 1213991 complement(3379551..3380090) 1 NC_003155.4 PF03641: possible lysine decarboxylase; hypothetical protein 3380090 1213991 SAV_2751 Streptomyces avermitilis MA-4680 hypothetical protein NP_823927.1 3379551 R 227882 CDS NP_823928.1 29829294 1213992 3380142..3380465 1 NC_003155.4 hypothetical protein 3380465 1213992 SAV_2752 Streptomyces avermitilis MA-4680 hypothetical protein NP_823928.1 3380142 D 227882 CDS NP_823929.1 29829295 1210544 complement(3380608..3381738) 1 NC_003155.4 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 3381738 mnmA 1210544 mnmA Streptomyces avermitilis MA-4680 tRNA-specific 2-thiouridylase MnmA NP_823929.1 3380608 R 227882 CDS NP_823930.1 29829296 1210545 3381799..3382455 1 NC_003155.4 PF01510: N-acetylmuramoyl-L-alanine amidase; N-acetylmuramoyl-L-alanine amidase 3382455 amiA1 1210545 amiA1 Streptomyces avermitilis MA-4680 N-acetylmuramoyl-L-alanine amidase NP_823930.1 3381799 D 227882 CDS NP_823931.1 29829297 1213993 3382802..3384250 1 NC_003155.4 multicopper oxidase 3384250 1213993 SAV_2755 Streptomyces avermitilis MA-4680 multicopper oxidase NP_823931.1 3382802 D 227882 CDS NP_823932.1 29829298 1213994 complement(3384316..3385485) 1 NC_003155.4 pyridoxal-phosphate-dependent aminotransferase 3385485 1213994 SAV_2756 Streptomyces avermitilis MA-4680 pyridoxal-phosphate-dependent aminotransferase NP_823932.1 3384316 R 227882 CDS NP_823933.1 29829299 1213995 complement(3385700..3385966) 1 NC_003155.4 hypothetical protein 3385966 1213995 SAV_2757 Streptomyces avermitilis MA-4680 hypothetical protein NP_823933.1 3385700 R 227882 CDS NP_823934.1 29829300 1213996 complement(3386006..3386173) 1 NC_003155.4 hypothetical protein 3386173 1213996 SAV_2758 Streptomyces avermitilis MA-4680 hypothetical protein NP_823934.1 3386006 R 227882 CDS NP_823935.1 29829301 1213997 3386308..3386934 1 NC_003155.4 TetR family transcriptional regulator 3386934 1213997 SAV_2759 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_823935.1 3386308 D 227882 CDS NP_823936.1 29829302 1213998 complement(3387595..3388551) 1 NC_003155.4 DeoR family transcriptional regulator 3388551 1213998 SAV_2760 Streptomyces avermitilis MA-4680 DeoR family transcriptional regulator NP_823936.1 3387595 R 227882 CDS NP_823937.1 29829303 1213999 3388666..3389250 1 NC_003155.4 hypothetical protein 3389250 1213999 SAV_2761 Streptomyces avermitilis MA-4680 hypothetical protein NP_823937.1 3388666 D 227882 CDS NP_823938.1 29829304 1214000 complement(3389237..3390097) 1 NC_003155.4 hypothetical protein 3390097 1214000 SAV_2762 Streptomyces avermitilis MA-4680 hypothetical protein NP_823938.1 3389237 R 227882 CDS NP_823939.1 29829305 1214001 complement(3390195..3390851) 1 NC_003155.4 PF03458: UPF0126 domain; hypothetical protein 3390851 1214001 SAV_2763 Streptomyces avermitilis MA-4680 hypothetical protein NP_823939.1 3390195 R 227882 CDS NP_823940.1 29829306 1214002 complement(3390899..3392290) 1 NC_003155.4 PF01433: Peptidase family M1; metallopeptidase 3392290 1214002 SAV_2764 Streptomyces avermitilis MA-4680 metallopeptidase NP_823940.1 3390899 R 227882 CDS NP_823941.1 29829307 1210546 complement(3392387..3393913) 1 NC_003155.4 tetra,pentapeptide transport system; ABC transporter ATP-binding protein 3393913 appF 1210546 appF Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_823941.1 3392387 R 227882 CDS NP_823942.1 29829308 1214003 complement(3393910..3395007) 1 NC_003155.4 ABC transporter ATP-binding protein 3395007 1214003 SAV_2766 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_823942.1 3393910 R 227882 CDS NP_823943.1 29829309 1214004 complement(3395004..3396011) 1 NC_003155.4 ABC transporter permease 3396011 dppB 1214004 dppB Streptomyces avermitilis MA-4680 ABC transporter permease NP_823943.1 3395004 R 227882 CDS NP_823944.1 29829310 1214005 complement(3396081..3397853) 1 NC_003155.4 ABC transporter substrate-binding protein 3397853 1214005 SAV_2768 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_823944.1 3396081 R 227882 CDS NP_823945.1 29829311 1214006 complement(3397890..3398888) 1 NC_003155.4 ABC transporter permease 3398888 appC 1214006 appC Streptomyces avermitilis MA-4680 ABC transporter permease NP_823945.1 3397890 R 227882 CDS NP_823946.1 29829312 1214007 complement(3399282..3400088) 1 NC_003155.4 hypothetical protein 3400088 1214007 SAV_2770 Streptomyces avermitilis MA-4680 hypothetical protein NP_823946.1 3399282 R 227882 CDS NP_823947.1 29829313 1214008 complement(3400233..3401015) 1 NC_003155.4 PF07179: SseB protein; hypothetical protein 3401015 1214008 SAV_2771 Streptomyces avermitilis MA-4680 hypothetical protein NP_823947.1 3400233 R 227882 CDS NP_823948.1 29829314 1214009 complement(3401168..3401854) 1 NC_003155.4 ATP/GTP-binding protein 3401854 1214009 SAV_2772 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_823948.1 3401168 R 227882 CDS NP_823949.1 29829315 1210547 3402270..3403388 1 NC_003155.4 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system protein T 3403388 gcvT 1210547 gcvT Streptomyces avermitilis MA-4680 glycine cleavage system protein T NP_823949.1 3402270 D 227882 CDS NP_823950.1 29829316 1210548 3403534..3403911 1 NC_003155.4 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 3403911 gcvH 1210548 gcvH Streptomyces avermitilis MA-4680 glycine cleavage system protein H NP_823950.1 3403534 D 227882 CDS NP_823951.1 29829317 1210549 3403925..3405187 1 NC_003155.4 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 3405187 glyA 1210549 glyA Streptomyces avermitilis MA-4680 serine hydroxymethyltransferase NP_823951.1 3403925 D 227882 CDS NP_823952.1 29829318 1210550 3405295..3406662 1 NC_003155.4 L-serine dehydratase 3406662 sdaA 1210550 sdaA Streptomyces avermitilis MA-4680 L-serine dehydratase NP_823952.1 3405295 D 227882 CDS NP_823953.1 29829319 1214010 3406782..3407336 1 NC_003155.4 PF01183: Glycosyl hydrolases family 25; glycosyl hydrolase 3407336 1214010 SAV_2777 Streptomyces avermitilis MA-4680 glycosyl hydrolase NP_823953.1 3406782 D 227882 CDS NP_823954.1 29829320 1214011 3407533..3407886 1 NC_003155.4 PF03473: MOSC domain; hypothetical protein 3407886 1214011 SAV_2778 Streptomyces avermitilis MA-4680 hypothetical protein NP_823954.1 3407533 D 227882 CDS NP_823955.1 29829321 1214012 complement(3407939..3408601) 1 NC_003155.4 PF03807: NADP oxidoreductase coenzyme F420-dependent; hypothetical protein 3408601 1214012 SAV_2779 Streptomyces avermitilis MA-4680 hypothetical protein NP_823955.1 3407939 R 227882 CDS NP_823956.1 29829322 1214013 complement(3408831..3409043) 1 NC_003155.4 PF00036: EF hand; calcium-binding protein 3409043 1214013 SAV_2780 Streptomyces avermitilis MA-4680 calcium-binding protein NP_823956.1 3408831 R 227882 CDS NP_823957.1 29829323 1214014 complement(3409094..3410020) 1 NC_003155.4 MerR family transcriptional regulator 3410020 1214014 SAV_2781 Streptomyces avermitilis MA-4680 MerR family transcriptional regulator NP_823957.1 3409094 R 227882 CDS NP_823958.1 29829324 1214015 3410077..3410793 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; hypothetical protein 3410793 1214015 SAV_2782 Streptomyces avermitilis MA-4680 hypothetical protein NP_823958.1 3410077 D 227882 CDS NP_823959.1 29829325 1214016 complement(3410760..3411956) 1 NC_003155.4 hypothetical protein 3411956 1214016 SAV_2783 Streptomyces avermitilis MA-4680 hypothetical protein NP_823959.1 3410760 R 227882 CDS NP_823960.1 29829326 1214017 complement(3411956..3412846) 1 NC_003155.4 polysaccharide deacetylase 3412846 1214017 SAV_2784 Streptomyces avermitilis MA-4680 polysaccharide deacetylase NP_823960.1 3411956 R 227882 CDS NP_823961.1 29829327 1214018 complement(3413140..3413748) 1 NC_003155.4 regulatory protein 3413748 1214018 SAV_2785 Streptomyces avermitilis MA-4680 regulatory protein NP_823961.1 3413140 R 227882 CDS NP_823962.1 29829328 1210551 complement(3413998..3414765) 1 NC_003155.4 enoyl-CoA hydratase 3414765 echA8 1210551 echA8 Streptomyces avermitilis MA-4680 enoyl-CoA hydratase NP_823962.1 3413998 R 227882 CDS NP_823963.1 29829329 1214019 complement(3414846..3416087) 1 NC_003155.4 PF03734: ErfK/YbiS/YcfS/YnhG; lipoprotein 3416087 1214019 SAV_2787 Streptomyces avermitilis MA-4680 lipoprotein NP_823963.1 3414846 R 227882 CDS NP_823964.1 29829330 1214020 complement(3416278..3417507) 1 NC_003155.4 PF03734: ErfK/YbiS/YcfS/YnhG; lipoprotein 3417507 1214020 SAV_2788 Streptomyces avermitilis MA-4680 lipoprotein NP_823964.1 3416278 R 227882 CDS NP_823965.1 29829331 1214021 3417664..3419913 1 NC_003155.4 glycogen debranching enzyme 3419913 1214021 SAV_2789 Streptomyces avermitilis MA-4680 glycogen debranching enzyme NP_823965.1 3417664 D 227882 CDS NP_823966.1 29829332 1214022 3419980..3421941 1 NC_003155.4 ABC transporter ATP-binding protein 3421941 1214022 SAV_2790 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_823966.1 3419980 D 227882 CDS NP_823967.1 29829333 1214023 3421938..3423800 1 NC_003155.4 ABC transporter ATP-binding protein 3423800 1214023 SAV_2791 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_823967.1 3421938 D 227882 CDS NP_823968.1 29829334 1214024 3423822..3425543 1 NC_003155.4 hypothetical protein 3425543 1214024 SAV_2792 Streptomyces avermitilis MA-4680 hypothetical protein NP_823968.1 3423822 D 227882 CDS NP_823969.1 29829335 1214025 3425540..3427306 1 NC_003155.4 ABC transporter ATP-binding protein 3427306 1214025 SAV_2793 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_823969.1 3425540 D 227882 CDS NP_823970.1 29829336 1214026 3427706..3429751 1 NC_003155.4 PF02868: Thermolysin metallopeptidase, alpha-helical domain; neutral zinc metalloprotease 3429751 1214026 SAV_2794 Streptomyces avermitilis MA-4680 neutral zinc metalloprotease NP_823970.1 3427706 D 227882 CDS NP_823971.1 29829337 1214027 3430049..3431713 1 NC_003155.4 PF02868: Thermolysin metallopeptidase, alpha-helical domain; neutral zinc metalloprotease 3431713 1214027 SAV_2795 Streptomyces avermitilis MA-4680 neutral zinc metalloprotease NP_823971.1 3430049 D 227882 CDS NP_823972.1 29829338 1214028 3431816..3432322 1 NC_003155.4 hypothetical protein 3432322 1214028 SAV_2796 Streptomyces avermitilis MA-4680 hypothetical protein NP_823972.1 3431816 D 227882 CDS NP_823973.1 29829339 1214029 complement(3432341..3432931) 1 NC_003155.4 regulatory protein 3432931 1214029 SAV_2797 Streptomyces avermitilis MA-4680 regulatory protein NP_823973.1 3432341 R 227882 CDS NP_823974.1 29829340 1214030 3433035..3433889 1 NC_003155.4 DNA-binding protein 3433889 1214030 SAV_2798 Streptomyces avermitilis MA-4680 DNA-binding protein NP_823974.1 3433035 D 227882 CDS NP_823975.1 29829341 1214031 3433901..3434089 1 NC_003155.4 PF04149: Domain of unknown function (DUF397); hypothetical protein 3434089 1214031 SAV_2799 Streptomyces avermitilis MA-4680 hypothetical protein NP_823975.1 3433901 D 227882 CDS NP_823976.1 29829342 1210552 complement(3434877..3437513) 1 NC_003155.4 glycogen phosphorylase 3437513 glgP 1210552 glgP Streptomyces avermitilis MA-4680 glycogen phosphorylase NP_823976.1 3434877 R 227882 CDS NP_823977.1 29829343 1214032 3437980..3439188 1 NC_003155.4 PF00082: Subtilase family; serine protease 3439188 1214032 SAV_2801 Streptomyces avermitilis MA-4680 serine protease NP_823977.1 3437980 D 227882 CDS NP_823978.1 29829344 1210553 3439435..3441540 1 NC_003155.4 alpha-amylase 3441540 amyA3 1210553 amyA3 Streptomyces avermitilis MA-4680 alpha-amylase NP_823978.1 3439435 D 227882 CDS NP_823979.1 29829345 1214033 3441537..3443255 1 NC_003155.4 trehalose synthase 3443255 treS1 1214033 treS1 Streptomyces avermitilis MA-4680 trehalose synthase NP_823979.1 3441537 D 227882 CDS NP_823980.1 29829346 1214034 3443356..3444756 1 NC_003155.4 pep2 protein 3444756 1214034 SAV_2804 Streptomyces avermitilis MA-4680 pep2 protein NP_823980.1 3443356 D 227882 CDS NP_823981.1 29829347 1210554 3444809..3447325 1 NC_003155.4 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme 3447325 glgB 1210554 glgB Streptomyces avermitilis MA-4680 glycogen branching enzyme NP_823981.1 3444809 D 227882 CDS NP_823982.1 29829348 1210555 complement(3447322..3448770) 1 NC_003155.4 CYP182A1; cytochrome P450 3448770 cyp12 1210555 cyp12 Streptomyces avermitilis MA-4680 cytochrome P450 NP_823982.1 3447322 R 227882 CDS NP_823983.1 29829349 1214035 complement(3448795..3451122) 1 NC_003155.4 PF00580: UvrD/REP helicase; hypothetical protein 3451122 1214035 SAV_2807 Streptomyces avermitilis MA-4680 hypothetical protein NP_823983.1 3448795 R 227882 CDS NP_823984.1 29829350 1210556 complement(3451261..3451575) 1 NC_003155.4 thioredoxin 3451575 trxA5 1210556 trxA5 Streptomyces avermitilis MA-4680 thioredoxin NP_823984.1 3451261 R 227882 CDS NP_823985.1 29829351 1214036 complement(3451590..3452018) 1 NC_003155.4 MerR family transcriptional regulator 3452018 1214036 SAV_2809 Streptomyces avermitilis MA-4680 MerR family transcriptional regulator NP_823985.1 3451590 R 227882 CDS NP_823986.1 29829352 1214037 complement(3452062..3452511) 1 NC_003155.4 transcription regulator AsnC 3452511 1214037 SAV_2810 Streptomyces avermitilis MA-4680 transcription regulator AsnC NP_823986.1 3452062 R 227882 CDS NP_823987.1 29829353 1214038 3452696..3453592 1 NC_003155.4 reductase 3453592 1214038 SAV_2811 Streptomyces avermitilis MA-4680 reductase NP_823987.1 3452696 D 227882 CDS NP_823988.1 29829354 1214039 3453820..3454674 1 NC_003155.4 PF00227: Proteasome A-type and B-type; 20S proteasome beta-subunit 3454674 prcB2 1214039 prcB2 Streptomyces avermitilis MA-4680 20S proteasome beta-subunit NP_823988.1 3453820 D 227882 CDS NP_823989.1 29829355 1214040 complement(3454813..3456540) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 3456540 1214040 SAV_2813 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_823989.1 3454813 R 227882 CDS NP_823990.1 29829356 1214041 3456690..3457307 1 NC_003155.4 regulatory protein 3457307 1214041 SAV_2814 Streptomyces avermitilis MA-4680 regulatory protein NP_823990.1 3456690 D 227882 CDS NP_823991.1 29829357 1214042 complement(3457386..3458798) 1 NC_003155.4 PF00375: Sodium:dicarboxylate symporter family; sodium:dicarboxylate symporter 3458798 dctA 1214042 dctA Streptomyces avermitilis MA-4680 sodium:dicarboxylate symporter NP_823991.1 3457386 R 227882 CDS NP_823992.1 29829358 1214043 3458968..3460665 1 NC_003155.4 two-component system sensor kinase 3460665 1214043 SAV_2816 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_823992.1 3458968 D 227882 CDS NP_823993.1 29829359 1214044 3460662..3461339 1 NC_003155.4 two-component system response regulator 3461339 1214044 SAV_2817 Streptomyces avermitilis MA-4680 two-component system response regulator NP_823993.1 3460662 D 227882 CDS NP_823994.1 29829360 1214045 3461710..3463107 1 NC_003155.4 ABC transporter substrate-binding protein 3463107 1214045 SAV_2818 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_823994.1 3461710 D 227882 CDS NP_823995.1 29829361 1214046 3463104..3464033 1 NC_003155.4 ABC transporter permease 3464033 1214046 SAV_2819 Streptomyces avermitilis MA-4680 ABC transporter permease NP_823995.1 3463104 D 227882 CDS NP_823996.1 29829362 1214047 3464035..3464874 1 NC_003155.4 PF00528: Binding-protein-dependent transport system inner membrane component; ABC transporter permease 3464874 1214047 SAV_2820 Streptomyces avermitilis MA-4680 ABC transporter permease NP_823996.1 3464035 D 227882 CDS NP_823997.1 29829363 1214048 3465344..3466060 1 NC_003155.4 hypothetical protein 3466060 1214048 SAV_2821 Streptomyces avermitilis MA-4680 hypothetical protein NP_823997.1 3465344 D 227882 CDS NP_823998.1 29829364 1210557 complement(3466103..3467128) 1 NC_003155.4 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 3467128 pfkA1 1210557 pfkA1 Streptomyces avermitilis MA-4680 6-phosphofructokinase NP_823998.1 3466103 R 227882 CDS NP_823999.1 29829365 1210558 3467325..3469415 1 NC_003155.4 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 3469415 pta 1210558 pta Streptomyces avermitilis MA-4680 phosphate acetyltransferase NP_823999.1 3467325 D 227882 CDS NP_824000.1 29829366 1210559 3469412..3470629 1 NC_003155.4 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 3470629 ackA 1210559 ackA Streptomyces avermitilis MA-4680 acetate kinase NP_824000.1 3469412 D 227882 CDS NP_824001.1 29829367 1210560 3470703..3472133 1 NC_003155.4 glycolysis; pyruvate kinase 3472133 pykA1 1210560 pykA1 Streptomyces avermitilis MA-4680 pyruvate kinase NP_824001.1 3470703 D 227882 CDS NP_824002.1 29829368 1214049 complement(3472320..3473618) 1 NC_003155.4 PF02987: Late embryogenesis abundant protein; hypothetical protein 3473618 1214049 SAV_2826 Streptomyces avermitilis MA-4680 hypothetical protein NP_824002.1 3472320 R 227882 CDS NP_824003.1 29829369 1214050 complement(3473608..3474174) 1 NC_003155.4 hypothetical protein 3474174 1214050 SAV_2827 Streptomyces avermitilis MA-4680 hypothetical protein NP_824003.1 3473608 R 227882 CDS NP_824004.1 29829370 1214051 complement(3474369..3475013) 1 NC_003155.4 cholesterol esterase 3475013 1214051 SAV_2829 Streptomyces avermitilis MA-4680 cholesterol esterase NP_824004.1 3474369 R 227882 CDS NP_824005.1 29829371 1214052 3474961..3475311 1 NC_003155.4 hypothetical protein 3475311 1214052 SAV_2828 Streptomyces avermitilis MA-4680 hypothetical protein NP_824005.1 3474961 D 227882 CDS NP_824006.1 29829372 1210561 complement(3475638..3476624) 1 NC_003155.4 thioredoxin 3476624 trxA6 1210561 trxA6 Streptomyces avermitilis MA-4680 thioredoxin NP_824006.1 3475638 R 227882 CDS NP_824007.1 29829373 1214053 3476861..3477496 1 NC_003155.4 TetR family transcriptional regulator 3477496 1214053 SAV_2831 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_824007.1 3476861 D 227882 CDS NP_824008.1 29829374 1210562 complement(3477658..3479358) 1 NC_003155.4 isobutyryl-CoA mutase subunit A 3479358 icmA 1210562 icmA Streptomyces avermitilis MA-4680 isobutyryl-CoA mutase subunit A NP_824008.1 3477658 R 227882 CDS NP_824009.1 29829375 1214054 complement(3479435..3479773) 1 NC_003155.4 hypothetical protein 3479773 1214054 SAV_2833 Streptomyces avermitilis MA-4680 hypothetical protein NP_824009.1 3479435 R 227882 CDS NP_824010.1 29829376 1214055 complement(3479839..3480273) 1 NC_003155.4 MarR family transcriptional regulator 3480273 1214055 SAV_2834 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_824010.1 3479839 R 227882 CDS NP_824011.1 29829377 1210563 complement(3480598..3482187) 1 NC_003155.4 spore-pigment gene cluster, PF01360: Monooxygenase; polyketide hydroxylase 3482187 sppF 1210563 sppF Streptomyces avermitilis MA-4680 polyketide hydroxylase NP_824011.1 3480598 R 227882 CDS NP_824012.1 29829378 1210564 3482594..3483718 1 NC_003155.4 spore-pigment gene cluster, PF04486: SchA / CurD like protein; WhiE I-like protein 3483718 sppG 1210564 sppG Streptomyces avermitilis MA-4680 WhiE I-like protein NP_824012.1 3482594 D 227882 CDS NP_824013.1 29829379 1210565 3483792..3484235 1 NC_003155.4 spore-pigment gene cluster; WhiE II-like protein 3484235 sppH 1210565 sppH Streptomyces avermitilis MA-4680 WhiE II-like protein NP_824013.1 3483792 D 227882 CDS NP_824014.1 29829380 1210566 3484232..3485497 1 NC_003155.4 spore-pigment gene cluster, PF00109: Beta-ketoacyl synthase, N-terminal domain; 3-oxoacyl-ACP synthase I 3485497 sppA 1210566 sppA Streptomyces avermitilis MA-4680 3-oxoacyl-ACP synthase I NP_824014.1 3484232 D 227882 CDS NP_824015.1 29829381 1210567 3485497..3486747 1 NC_003155.4 spore-pigment gene cluster, PF00109: Beta-ketoacyl synthase, N-terminal domain; 3-oxoacyl-ACP synthase II, chain length factor 3486747 sppB 1210567 sppB Streptomyces avermitilis MA-4680 3-oxoacyl-ACP synthase II, chain length factor NP_824015.1 3485497 D 227882 CDS NP_824016.1 29829382 1210568 3486734..3487018 1 NC_003155.4 spore-pigment gene cluster, PF00550: Phosphopantetheine attachment site; ACP 3487018 sppC 1210568 sppC Streptomyces avermitilis MA-4680 ACP NP_824016.1 3486734 D 227882 CDS NP_824017.1 29829383 1210569 3487020..3487499 1 NC_003155.4 spore-pigment gene cluster, PF03364: Streptomyces cyclase/dehydrase; cyclase I 3487499 sppD 1210569 sppD Streptomyces avermitilis MA-4680 cyclase I NP_824017.1 3487020 D 227882 CDS NP_824018.1 29829384 1210570 3487579..3487905 1 NC_003155.4 spore-pigment gene cluster, PF04673: Polyketide synthesis cyclase; cyclase II 3487905 sppE 1210570 sppE Streptomyces avermitilis MA-4680 cyclase II NP_824018.1 3487579 D 227882 CDS NP_824019.1 29829385 1214056 complement(3488000..3488995) 1 NC_003155.4 O-methyltransferase 3488995 1214056 SAV_2843 Streptomyces avermitilis MA-4680 O-methyltransferase NP_824019.1 3488000 R 227882 CDS NP_824020.1 29829386 1214057 complement(3489081..3490139) 1 NC_003155.4 PF07602: Protein of unknown function (DUF1565); protein 3490139 1214057 SAV_2844 Streptomyces avermitilis MA-4680 protein NP_824020.1 3489081 R 227882 CDS NP_824021.1 29829387 1214058 complement(3490385..3491017) 1 NC_003155.4 TetR family transcriptional regulator 3491017 1214058 SAV_2845 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_824021.1 3490385 R 227882 CDS NP_824022.1 29829388 1214059 complement(3491014..3491694) 1 NC_003155.4 hypothetical protein 3491694 1214059 SAV_2846 Streptomyces avermitilis MA-4680 hypothetical protein NP_824022.1 3491014 R 227882 CDS NP_824023.1 29829389 1214060 complement(3491691..3492443) 1 NC_003155.4 hypothetical protein 3492443 1214060 SAV_2847 Streptomyces avermitilis MA-4680 hypothetical protein NP_824023.1 3491691 R 227882 CDS NP_824024.1 29829390 1214061 complement(3492609..3492902) 1 NC_003155.4 PF01910: Domain of unknown function DUF77; hypothetical protein 3492902 1214061 SAV_2848 Streptomyces avermitilis MA-4680 hypothetical protein NP_824024.1 3492609 R 227882 CDS NP_824025.1 29829391 1214062 complement(3492899..3493243) 1 NC_003155.4 hypothetical protein 3493243 1214062 SAV_2849 Streptomyces avermitilis MA-4680 hypothetical protein NP_824025.1 3492899 R 227882 CDS NP_824026.1 29829392 1214063 3493420..3494052 1 NC_003155.4 PF01987: Protein of unknown function DUF124; hypothetical protein 3494052 1214063 SAV_2850 Streptomyces avermitilis MA-4680 hypothetical protein NP_824026.1 3493420 D 227882 CDS NP_824027.1 29829393 1214064 3494045..3494704 1 NC_003155.4 PF01987: Protein of unknown function DUF124; hypothetical protein 3494704 1214064 SAV_2851 Streptomyces avermitilis MA-4680 hypothetical protein NP_824027.1 3494045 D 227882 CDS NP_824028.1 29829394 1214065 3494701..3495498 1 NC_003155.4 PF01987: Protein of unknown function DUF124; hypothetical protein 3495498 1214065 SAV_2852 Streptomyces avermitilis MA-4680 hypothetical protein NP_824028.1 3494701 D 227882 CDS NP_824029.1 29829395 1214066 3495591..3496067 1 NC_003155.4 MarR family transcriptional regulator 3496067 1214066 SAV_2853 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_824029.1 3495591 D 227882 CDS NP_824030.1 29829396 1214067 complement(3496431..3497429) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; hypothetical protein 3497429 1214067 SAV_2854 Streptomyces avermitilis MA-4680 hypothetical protein NP_824030.1 3496431 R 227882 CDS NP_824031.1 29829397 1214068 complement(3497612..3498568) 1 NC_003155.4 lysine arginine ornithine transport system kinase 3498568 argK2 1214068 argK2 Streptomyces avermitilis MA-4680 lysine arginine ornithine transport system kinase NP_824031.1 3497612 R 227882 CDS NP_824032.1 29829398 1210571 complement(3498639..3499841) 1 NC_003155.4 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase 3499841 fadA1 1210571 fadA1 Streptomyces avermitilis MA-4680 acetyl-CoA acetyltransferase NP_824032.1 3498639 R 227882 CDS NP_824033.1 29829399 1214069 3499939..3500430 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein 3500430 1214069 SAV_2857 Streptomyces avermitilis MA-4680 hypothetical protein NP_824033.1 3499939 D 227882 CDS NP_824034.1 29829400 1214070 3500758..3504534 1 NC_003155.4 PF02370: M protein repeat; M protein 3504534 1214070 SAV_2858 Streptomyces avermitilis MA-4680 M protein NP_824034.1 3500758 D 227882 CDS NP_824035.1 29829401 1214071 3504717..3505655 1 NC_003155.4 cellulose-binding protein 3505655 1214071 SAV_2859 Streptomyces avermitilis MA-4680 cellulose-binding protein NP_824035.1 3504717 D 227882 CDS NP_824036.1 29829402 1214072 3505744..3506694 1 NC_003155.4 ABC transporter ATP-binding protein 3506694 1214072 SAV_2860 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_824036.1 3505744 D 227882 CDS NP_824037.1 29829403 1214073 3506697..3507467 1 NC_003155.4 ABC transporter permease 3507467 1214073 SAV_2861 Streptomyces avermitilis MA-4680 ABC transporter permease NP_824037.1 3506697 D 227882 CDS NP_824038.1 29829404 1214074 3507648..3508979 1 NC_003155.4 ABC transporter ATP-binding protein 3508979 1214074 SAV_2862 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_824038.1 3507648 D 227882 CDS NP_824039.1 29829405 1214075 3509005..3509874 1 NC_003155.4 ABC transporter permease 3509874 1214075 SAV_2863 Streptomyces avermitilis MA-4680 ABC transporter permease NP_824039.1 3509005 D 227882 CDS NP_824040.1 29829406 1214076 complement(3509904..3510236) 1 NC_003155.4 ATP/GTP-binding protein 3510236 1214076 SAV_2864 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_824040.1 3509904 R 227882 CDS NP_824041.1 29829407 1214077 3510457..3511485 1 NC_003155.4 luciferase-family protein 3511485 1214077 SAV_2865 Streptomyces avermitilis MA-4680 luciferase-family protein NP_824041.1 3510457 D 227882 CDS NP_824042.1 29829408 1214078 complement(3511582..3511974) 1 NC_003155.4 hypothetical protein 3511974 1214078 SAV_2866 Streptomyces avermitilis MA-4680 hypothetical protein NP_824042.1 3511582 R 227882 CDS NP_824043.1 29829409 1214079 3512218..3512889 1 NC_003155.4 PF01939: Protein of unknown function DUF91; hypothetical protein 3512889 1214079 SAV_2867 Streptomyces avermitilis MA-4680 hypothetical protein NP_824043.1 3512218 D 227882 CDS NP_824044.1 29829410 1214080 complement(3513017..3515560) 1 NC_003155.4 PF05729: NACHT domain; hypothetical protein 3515560 1214080 SAV_2868 Streptomyces avermitilis MA-4680 hypothetical protein NP_824044.1 3513017 R 227882 CDS NP_824045.1 29829411 1214081 complement(3515964..3516287) 1 NC_003155.4 PF01740: STAS domain; anti-sigma factor antagonist 3516287 1214081 SAV_2869 Streptomyces avermitilis MA-4680 anti-sigma factor antagonist NP_824045.1 3515964 R 227882 CDS NP_824046.1 29829412 1210572 complement(3516433..3517281) 1 NC_003155.4 PF02737: 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; 3-hydroxyacyl-CoA dehydrogenase 3517281 fadC3 1210572 fadC3 Streptomyces avermitilis MA-4680 3-hydroxyacyl-CoA dehydrogenase NP_824046.1 3516433 R 227882 CDS NP_824047.1 29829413 1214082 complement(3517449..3518090) 1 NC_003155.4 TetR family transcriptional regulator 3518090 1214082 SAV_2871 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_824047.1 3517449 R 227882 CDS NP_824048.1 29829414 1214083 3518171..3518953 1 NC_003155.4 ABC transporter ATP-binding protein 3518953 1214083 SAV_2872 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_824048.1 3518171 D 227882 CDS NP_824049.1 29829415 1214084 3518985..3519734 1 NC_003155.4 hypothetical protein 3519734 1214084 SAV_2873 Streptomyces avermitilis MA-4680 hypothetical protein NP_824049.1 3518985 D 227882 CDS NP_824050.1 29829416 1214085 3519748..3520320 1 NC_003155.4 cobalamin adenosyltransferase 3520320 1214085 SAV_2874 Streptomyces avermitilis MA-4680 cobalamin adenosyltransferase NP_824050.1 3519748 D 227882 CDS NP_824051.1 29829417 1214086 complement(3520317..3520940) 1 NC_003155.4 hypothetical protein 3520940 1214086 SAV_2875 Streptomyces avermitilis MA-4680 hypothetical protein NP_824051.1 3520317 R 227882 CDS NP_824052.1 29829418 1210573 3521015..3522199 1 NC_003155.4 two-component system sensor kinase 3522199 chiS 1210573 chiS Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_824052.1 3521015 D 227882 CDS NP_824053.1 29829419 1210574 3522196..3522837 1 NC_003155.4 two-component system response regulator 3522837 chiR 1210574 chiR Streptomyces avermitilis MA-4680 two-component system response regulator NP_824053.1 3522196 D 227882 CDS NP_824054.1 29829420 1210575 3522979..3524802 1 NC_003155.4 chitinase C precursor 3524802 chiC 1210575 chiC Streptomyces avermitilis MA-4680 chitinase C precursor NP_824054.1 3522979 D 227882 CDS NP_824055.1 29829421 1214087 complement(3524875..3525327) 1 NC_003155.4 hypothetical protein 3525327 1214087 SAV_2879 Streptomyces avermitilis MA-4680 hypothetical protein NP_824055.1 3524875 R 227882 CDS NP_824056.1 29829422 1210576 complement(3525460..3525834) 1 NC_003155.4 produces ATP from ADP in the presence of a proton gradient across the membrane; the epsilon subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit epsilon 3525834 atpC 1210576 atpC Streptomyces avermitilis MA-4680 F0F1 ATP synthase subunit epsilon NP_824056.1 3525460 R 227882 CDS NP_824057.1 29829423 1210577 complement(3525945..3527381) 1 NC_003155.4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 3527381 atpD 1210577 atpD Streptomyces avermitilis MA-4680 F0F1 ATP synthase subunit beta NP_824057.1 3525945 R 227882 CDS NP_824058.1 29829424 1210578 complement(3527381..3528298) 1 NC_003155.4 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 3528298 atpG 1210578 atpG Streptomyces avermitilis MA-4680 F0F1 ATP synthase subunit gamma NP_824058.1 3527381 R 227882 CDS NP_824059.1 29829425 1210579 complement(3528320..3529909) 1 NC_003155.4 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 3529909 atpA 1210579 atpA Streptomyces avermitilis MA-4680 F0F1 ATP synthase subunit alpha NP_824059.1 3528320 R 227882 CDS NP_824060.1 29829426 1210580 complement(3530039..3530860) 1 NC_003155.4 produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 3530860 atpH 1210580 atpH Streptomyces avermitilis MA-4680 F0F1 ATP synthase subunit delta NP_824060.1 3530039 R 227882 CDS NP_824061.1 29829427 1210581 complement(3530857..3531417) 1 NC_003155.4 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 3531417 atpF 1210581 atpF Streptomyces avermitilis MA-4680 F0F1 ATP synthase subunit B NP_824061.1 3530857 R 227882 CDS NP_824062.1 29829428 1210582 complement(3531439..3531681) 1 NC_003155.4 PF00137: ATP synthase subunit C; F-type proton-transporting ATPase c chain 3531681 atpE 1210582 atpE Streptomyces avermitilis MA-4680 F-type proton-transporting ATPase c chain NP_824062.1 3531439 R 227882 CDS NP_824063.1 29829429 1210583 complement(3531750..3532559) 1 NC_003155.4 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 3532559 atpB 1210583 atpB Streptomyces avermitilis MA-4680 F0F1 ATP synthase subunit A NP_824063.1 3531750 R 227882 CDS NP_824064.1 29829430 1210584 complement(3532782..3533195) 1 NC_003155.4 PF06942: GlpM protein; ATP synthase protein I 3533195 atpI 1210584 atpI Streptomyces avermitilis MA-4680 ATP synthase protein I NP_824064.1 3532782 R 227882 CDS NP_824065.1 29829431 1210585 complement(3533486..3534304) 1 NC_003155.4 converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; 3-hydroxybutyryl-CoA dehydrogenase 3534304 fadC4 1210585 fadC4 Streptomyces avermitilis MA-4680 3-hydroxybutyryl-CoA dehydrogenase NP_824065.1 3533486 R 227882 CDS NP_824066.1 29829432 1210586 complement(3534525..3535877) 1 NC_003155.4 concerning oligomycin biosynthesis; crotonyl-CoA reductase 3535877 ccrA1 1210586 ccrA1 Streptomyces avermitilis MA-4680 crotonyl-CoA reductase NP_824066.1 3534525 R 227882 CDS NP_824067.1 29829433 1214088 complement(3536018..3536521) 1 NC_003155.4 hypothetical protein 3536521 1214088 SAV_2891 Streptomyces avermitilis MA-4680 hypothetical protein NP_824067.1 3536018 R 227882 CDS NP_824068.1 29829434 1210587 3536766..3548678 1 NC_003155.4 oligomycin gene cluster; modular polyketide synthase 3548678 olmA4 1210587 olmA4 Streptomyces avermitilis MA-4680 modular polyketide synthase NP_824068.1 3536766 D 227882 CDS NP_824069.1 29829435 1210588 3548827..3554550 1 NC_003155.4 oligomycin gene cluster; modular polyketide synthase 3554550 olmA5 1210588 olmA5 Streptomyces avermitilis MA-4680 modular polyketide synthase NP_824069.1 3548827 D 227882 CDS NP_824070.1 29829436 1210589 3554746..3555960 1 NC_003155.4 CYP107W1, oligomycin gene cluster; cytochrome P450 hydroxylase 3555960 olmB 1210589 olmB Streptomyces avermitilis MA-4680 cytochrome P450 hydroxylase NP_824070.1 3554746 D 227882 CDS NP_824071.1 29829437 1210590 complement(3556431..3567272) 1 NC_003155.4 oligomycin gene cluster; modular polyketide synthase 3567272 olmA7 1210590 olmA7 Streptomyces avermitilis MA-4680 modular polyketide synthase NP_824071.1 3556431 R 227882 CDS NP_824072.1 29829438 1210591 complement(3567331..3581388) 1 NC_003155.4 oligomycin gene cluster; modular polyketide synthase 3581388 olmA6 1210591 olmA6 Streptomyces avermitilis MA-4680 modular polyketide synthase NP_824072.1 3567331 R 227882 CDS NP_824073.1 29829439 1210592 complement(3581534..3593353) 1 NC_003155.4 oligomycin gene cluster; modular polyketide synthase 3593353 olmA3 1210592 olmA3 Streptomyces avermitilis MA-4680 modular polyketide synthase NP_824073.1 3581534 R 227882 CDS NP_824074.1 29829440 1210593 complement(3593359..3607881) 1 NC_003155.4 oligomycin gene cluster; modular polyketide synthase 3607881 olmA2 1210593 olmA2 Streptomyces avermitilis MA-4680 modular polyketide synthase NP_824074.1 3593359 R 227882 CDS NP_824075.1 29829441 1210594 complement(3607907..3626347) 1 NC_003155.4 oligomycin gene cluster; modular polyketide synthase 3626347 olmA1 1210594 olmA1 Streptomyces avermitilis MA-4680 modular polyketide synthase NP_824075.1 3607907 R 227882 CDS NP_824076.1 29829442 1214089 complement(3626534..3626872) 1 NC_003155.4 probably pseudogene; P450-like protein 3626872 1214089 SAV_2900 Streptomyces avermitilis MA-4680 P450-like protein NP_824076.1 3626534 R 227882 CDS NP_824077.1 29829443 1210595 complement(3627319..3630147) 1 NC_003155.4 oligomycin gene cluster; LuxR family transcriptional regulator 3630147 olmRII 1210595 olmRII Streptomyces avermitilis MA-4680 LuxR family transcriptional regulator NP_824077.1 3627319 R 227882 CDS NP_824078.1 29829444 1210596 complement(3630367..3633162) 1 NC_003155.4 oligomycin gene cluster; LuxR family transcriptional regulator 3633162 olmRI 1210596 olmRI Streptomyces avermitilis MA-4680 LuxR family transcriptional regulator NP_824078.1 3630367 R 227882 CDS NP_824079.1 29829445 1210597 complement(3633834..3634592) 1 NC_003155.4 oligomycin gene cluster; thioesterase 3634592 olmC 1210597 olmC Streptomyces avermitilis MA-4680 thioesterase NP_824079.1 3633834 R 227882 CDS NP_824080.1 29829446 1214090 3634930..3635895 1 NC_003155.4 SimX4-like protein 3635895 1214090 SAV_2904 Streptomyces avermitilis MA-4680 SimX4-like protein NP_824080.1 3634930 D 227882 CDS NP_824081.1 29829447 1210598 3635892..3636674 1 NC_003155.4 PF01648: 4'-phosphopantetheinyl transferase superfamily; phosphopantetheinyl transferase 3636674 pptA1 1210598 pptA1 Streptomyces avermitilis MA-4680 phosphopantetheinyl transferase NP_824081.1 3635892 D 227882 CDS NP_824082.1 29829448 1210599 3636671..3637804 1 NC_003155.4 methylmalonyl-CoA mutase subunit alpha 3637804 mcmA1 1210599 mcmA1 Streptomyces avermitilis MA-4680 methylmalonyl-CoA mutase subunit alpha NP_824082.1 3636671 D 227882 CDS NP_824083.1 29829449 1210600 complement(3637912..3639336) 1 NC_003155.4 teichoic acid linkage unit synthesis (synthesis of UDPpyrophosphate-N- aetylglucosamine) 3639336 tagO 1210600 tagO Streptomyces avermitilis MA-4680 teichoic acid linkage unit synthesis (synthesis of UDPpyrophosphate-N- aetylglucosamine) NP_824083.1 3637912 R 227882 CDS NP_824084.1 29829450 1210601 complement(3639464..3640735) 1 NC_003155.4 serine hydroxymethyltransferase 3640735 glyA2 1210601 glyA2 Streptomyces avermitilis MA-4680 serine hydroxymethyltransferase NP_824084.1 3639464 R 227882 CDS NP_824085.1 29829451 1214091 complement(3640880..3641545) 1 NC_003155.4 PF01451: Low molecular weight phosphotyrosine protein phosphatase; low molecular weight protein tyrosine phosphatase 3641545 ptpB3 1214091 ptpB3 Streptomyces avermitilis MA-4680 low molecular weight protein tyrosine phosphatase NP_824085.1 3640880 R 227882 CDS NP_824086.1 29829452 1214092 complement(3641542..3642189) 1 NC_003155.4 PF01300: yrdC domain; hypothetical protein 3642189 1214092 SAV_2910 Streptomyces avermitilis MA-4680 hypothetical protein NP_824086.1 3641542 R 227882 CDS NP_824087.1 29829453 1214093 complement(3642242..3643123) 1 NC_003155.4 methyltransferase 3643123 1214093 SAV_2911 Streptomyces avermitilis MA-4680 methyltransferase NP_824087.1 3642242 R 227882 CDS NP_824088.1 29829454 1210602 complement(3643170..3644246) 1 NC_003155.4 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 3644246 prfA 1210602 prfA Streptomyces avermitilis MA-4680 peptide chain release factor 1 NP_824088.1 3643170 R 227882 CDS NP_824089.1 29829455 1210603 complement(3644421..3644642) 1 NC_003155.4 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 3644642 rpmE 1210603 rpmE Streptomyces avermitilis MA-4680 50S ribosomal protein L31 NP_824089.1 3644421 R 227882 CDS NP_824090.1 29829456 1214094 complement(3644839..3645978) 1 NC_003155.4 transcriptional regulator 3645978 1214094 SAV_2914 Streptomyces avermitilis MA-4680 transcriptional regulator NP_824090.1 3644839 R 227882 CDS NP_824091.1 29829457 1210604 complement(3646335..3648401) 1 NC_003155.4 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 3648401 rho 1210604 rho Streptomyces avermitilis MA-4680 transcription termination factor Rho NP_824091.1 3646335 R 227882 CDS NP_824092.1 29829458 1210605 complement(3648821..3649738) 1 NC_003155.4 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 3649738 thrB 1210605 thrB Streptomyces avermitilis MA-4680 homoserine kinase NP_824092.1 3648821 R 227882 CDS NP_824093.1 29829459 1210606 complement(3650076..3651134) 1 NC_003155.4 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 3651134 thrC1 1210606 thrC1 Streptomyces avermitilis MA-4680 threonine synthase NP_824093.1 3650076 R 227882 CDS NP_824094.1 29829460 1210607 complement(3651141..3652430) 1 NC_003155.4 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 3652430 thrA 1210607 thrA Streptomyces avermitilis MA-4680 homoserine dehydrogenase NP_824094.1 3651141 R 227882 CDS NP_824095.1 29829461 1210608 complement(3652587..3653978) 1 NC_003155.4 PF02784: Pyridoxal-dependent decarboxylase, pyridoxal binding domain; diaminopimelate decarboxylase 3653978 lysA1 1210608 lysA1 Streptomyces avermitilis MA-4680 diaminopimelate decarboxylase NP_824095.1 3652587 R 227882 CDS NP_824096.1 29829462 1210609 complement(3654002..3655060) 1 NC_003155.4 arginyl-tRNA synthetase 3655060 argS1 1210609 argS1 Streptomyces avermitilis MA-4680 arginyl-tRNA synthetase NP_824096.1 3654002 R 227882 CDS NP_824097.1 29829463 1214095 complement(3655220..3655813) 1 NC_003155.4 two-component system response regulator 3655813 1214095 SAV_2921 Streptomyces avermitilis MA-4680 two-component system response regulator NP_824097.1 3655220 R 227882 CDS NP_824098.1 29829464 1214096 complement(3656330..3657742) 1 NC_003155.4 integrin homolog, PF01839: FG-GAP repeat; hypothetical protein 3657742 1214096 SAV_2922 Streptomyces avermitilis MA-4680 hypothetical protein NP_824098.1 3656330 R 227882 CDS NP_824099.1 29829465 1214097 complement(3657810..3659339) 1 NC_003155.4 integrin homolog, PF01839: FG-GAP repeat; hypothetical protein 3659339 1214097 SAV_2923 Streptomyces avermitilis MA-4680 hypothetical protein NP_824099.1 3657810 R 227882 CDS NP_824100.1 29829466 1214098 3659419..3659685 1 NC_003155.4 hypothetical protein 3659685 1214098 SAV_2924 Streptomyces avermitilis MA-4680 hypothetical protein NP_824100.1 3659419 D 227882 CDS NP_824101.1 29829467 1214099 complement(3662215..3664023) 1 NC_003155.4 hypothetical protein 3664023 1214099 SAV_2925 Streptomyces avermitilis MA-4680 hypothetical protein NP_824101.1 3662215 R 227882 CDS NP_824102.1 29829468 1214100 complement(3664680..3666734) 1 NC_003155.4 PF02463: RecF/RecN/SMC N terminal domain; hypothetical protein 3666734 1214100 SAV_2926 Streptomyces avermitilis MA-4680 hypothetical protein NP_824102.1 3664680 R 227882 CDS NP_824103.1 29829469 1214101 complement(3666731..3666895) 1 NC_003155.4 hypothetical protein 3666895 1214101 SAV_2927 Streptomyces avermitilis MA-4680 hypothetical protein NP_824103.1 3666731 R 227882 CDS NP_824104.1 29829470 1214102 complement(3666923..3669067) 1 NC_003155.4 DNA repair helicase 3669067 1214102 SAV_2928 Streptomyces avermitilis MA-4680 DNA repair helicase NP_824104.1 3666923 R 227882 CDS NP_824105.1 29829471 1214103 complement(3672466..3672861) 1 NC_003155.4 hypothetical protein 3672861 1214103 SAV_2929 Streptomyces avermitilis MA-4680 hypothetical protein NP_824105.1 3672466 R 227882 CDS NP_824106.1 29829472 1214104 complement(3672836..3674863) 1 NC_003155.4 PF02463: RecF/RecN/SMC N terminal domain; hypothetical protein 3674863 1214104 SAV_2930 Streptomyces avermitilis MA-4680 hypothetical protein NP_824106.1 3672836 R 227882 CDS NP_824107.1 29829473 1214105 complement(3674850..3676427) 1 NC_003155.4 PF01507: Phosphoadenosine phosphosulfate reductase family; hypothetical protein 3676427 1214105 SAV_2931 Streptomyces avermitilis MA-4680 hypothetical protein NP_824107.1 3674850 R 227882 CDS NP_824108.1 29829474 1214106 complement(3676424..3677563) 1 NC_003155.4 hypothetical protein 3677563 1214106 SAV_2932 Streptomyces avermitilis MA-4680 hypothetical protein NP_824108.1 3676424 R 227882 CDS NP_824109.1 29829475 1210611 3677808..3678962 1 NC_003155.4 L-cysteine desulfurase (pyridoxal phosphate-dependent) 3678962 iscS 1210611 iscS Streptomyces avermitilis MA-4680 L-cysteine desulfurase (pyridoxal phosphate-dependent) NP_824109.1 3677808 D 227882 CDS NP_824110.1 29829476 1214107 complement(3678968..3680404) 1 NC_003155.4 hypothetical protein 3680404 1214107 SAV_2934 Streptomyces avermitilis MA-4680 hypothetical protein NP_824110.1 3678968 R 227882 CDS NP_824111.1 29829477 1214108 3683155..3683652 1 NC_003155.4 hypothetical protein 3683652 1214108 SAV_2935 Streptomyces avermitilis MA-4680 hypothetical protein NP_824111.1 3683155 D 227882 CDS NP_824112.1 29829478 1214109 complement(3683691..3684662) 1 NC_003155.4 PF00589: Phage integrase family; integrase 3684662 int5 1214109 int5 Streptomyces avermitilis MA-4680 integrase NP_824112.1 3683691 R 227882 CDS NP_824113.1 29829479 1214110 complement(3684643..3684981) 1 NC_003155.4 integrase 3684981 int6 1214110 int6 Streptomyces avermitilis MA-4680 integrase NP_824113.1 3684643 R 227882 CDS NP_824114.1 29829480 1210612 complement(3685159..3685857) 1 NC_003155.4 replication initiator protein 3685857 repSA3 1210612 repSA3 Streptomyces avermitilis MA-4680 replication initiator protein NP_824114.1 3685159 R 227882 CDS NP_824115.1 29829481 1214111 complement(3686010..3686846) 1 NC_003155.4 PF02031: Streptomyces extracellular neutral proteinase (M7) family; metalloprotease 3686846 1214111 SAV_2939 Streptomyces avermitilis MA-4680 metalloprotease NP_824115.1 3686010 R 227882 CDS NP_824116.1 29829482 1214112 complement(3687593..3688159) 1 NC_003155.4 hypothetical protein 3688159 1214112 SAV_2940 Streptomyces avermitilis MA-4680 hypothetical protein NP_824116.1 3687593 R 227882 CDS NP_824117.1 29829483 1214113 3689026..3689523 1 NC_003155.4 hypothetical protein 3689523 1214113 SAV_2941 Streptomyces avermitilis MA-4680 hypothetical protein NP_824117.1 3689026 D 227882 CDS NP_824118.1 29829484 1214114 3689583..3689798 1 NC_003155.4 hypothetical protein 3689798 1214114 SAV_2942 Streptomyces avermitilis MA-4680 hypothetical protein NP_824118.1 3689583 D 227882 CDS NP_824119.1 29829485 1214115 complement(3689937..3691580) 1 NC_003155.4 hypothetical protein 3691580 1214115 SAV_2943 Streptomyces avermitilis MA-4680 hypothetical protein NP_824119.1 3689937 R 227882 CDS NP_824120.1 29829486 1210613 3692368..3693618 1 NC_003155.4 PF00109: Beta-ketoacyl synthase, N-terminal domain; 3-oxoacyl-ACP synthase II 3693618 fabB2 1210613 fabB2 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP synthase II NP_824120.1 3692368 D 227882 CDS NP_824121.1 29829487 1214116 complement(3693749..3694849) 1 NC_003155.4 probably involving non-homologous end-joining; Ku70/Ku80 protein 3694849 ku1 1214116 ku1 Streptomyces avermitilis MA-4680 Ku70/Ku80 protein NP_824121.1 3693749 R 227882 CDS NP_824122.1 29829488 1214117 3694892..3695773 1 NC_003155.4 ATP-dependent DNA ligase; DNA ligase 3695773 ligD 1214117 ligD Streptomyces avermitilis MA-4680 DNA ligase NP_824122.1 3694892 D 227882 CDS NP_824123.1 29829489 1214118 complement(3695855..3696658) 1 NC_003155.4 hypothetical protein 3696658 1214118 SAV_2947 Streptomyces avermitilis MA-4680 hypothetical protein NP_824123.1 3695855 R 227882 CDS NP_824124.1 29829490 1214119 3696783..3697262 1 NC_003155.4 PF00782: Dual specificity phosphatase, catalytic domain; conventional protein tyrosine phosphatase 3697262 ptpA3 1214119 ptpA3 Streptomyces avermitilis MA-4680 conventional protein tyrosine phosphatase NP_824124.1 3696783 D 227882 CDS NP_824125.1 29829491 1214120 3697443..3698333 1 NC_003155.4 lipoprotein 3698333 1214120 SAV_2949 Streptomyces avermitilis MA-4680 lipoprotein NP_824125.1 3697443 D 227882 CDS NP_824126.1 29829492 1214121 3698330..3699625 1 NC_003155.4 two-component system sensor kinase 3699625 1214121 SAV_2950 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_824126.1 3698330 D 227882 CDS NP_824127.1 29829493 1214122 3699662..3701029 1 NC_003155.4 PF01098: Cell cycle protein; cell division membrane protein 3701029 ftsW4 1214122 ftsW4 Streptomyces avermitilis MA-4680 cell division membrane protein NP_824127.1 3699662 D 227882 CDS NP_824128.1 29829494 1210614 3701049..3702506 1 NC_003155.4 PF00905: Penicillin binding protein transpeptidase domain; penicillin-binding protein 3702506 pbp1 1210614 pbp1 Streptomyces avermitilis MA-4680 penicillin-binding protein NP_824128.1 3701049 D 227882 CDS NP_824129.1 29829495 1214123 complement(3702582..3703688) 1 NC_003155.4 hypothetical protein 3703688 1214123 SAV_2953 Streptomyces avermitilis MA-4680 hypothetical protein NP_824129.1 3702582 R 227882 CDS NP_824130.1 29829496 1214124 3703839..3704774 1 NC_003155.4 hypothetical protein 3704774 1214124 SAV_2954 Streptomyces avermitilis MA-4680 hypothetical protein NP_824130.1 3703839 D 227882 CDS NP_824131.1 29829497 1214125 3705104..3705829 1 NC_003155.4 TetR family transcriptional regulator 3705829 1214125 SAV_2955 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_824131.1 3705104 D 227882 CDS NP_824132.1 29829498 1214126 3705840..3706205 1 NC_003155.4 hypothetical protein 3706205 1214126 SAV_2956 Streptomyces avermitilis MA-4680 hypothetical protein NP_824132.1 3705840 D 227882 CDS NP_824133.1 29829499 1214127 3706309..3707724 1 NC_003155.4 NLP/P60-family protein 3707724 1214127 SAV_2957 Streptomyces avermitilis MA-4680 NLP/P60-family protein NP_824133.1 3706309 D 227882 CDS NP_824134.1 29829500 1214128 complement(3707729..3708982) 1 NC_003155.4 oxygenase subunit 3708982 1214128 SAV_2958 Streptomyces avermitilis MA-4680 oxygenase subunit NP_824134.1 3707729 R 227882 CDS NP_824135.1 29829501 1210615 complement(3709010..3709636) 1 NC_003155.4 multi-component regulatory system-8; ATP/GTP-binding protein 3709636 cvnD8 1210615 cvnD8 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_824135.1 3709010 R 227882 CDS NP_824136.1 29829502 1210616 complement(3709617..3710033) 1 NC_003155.4 multi-component regulatory system-8, PF05331: Protein of unknown function (DUF742); hypothetical protein 3710033 cvnC8 1210616 cvnC8 Streptomyces avermitilis MA-4680 hypothetical protein NP_824136.1 3709617 R 227882 CDS NP_824137.1 29829503 1210617 complement(3710030..3710455) 1 NC_003155.4 multi-component regulatory system-8, PF03259: Roadblock/LC7 domain; hypothetical protein 3710455 cvnB8 1210617 cvnB8 Streptomyces avermitilis MA-4680 hypothetical protein NP_824137.1 3710030 R 227882 CDS NP_824138.1 29829504 1210618 complement(3710530..3713454) 1 NC_003155.4 multi-component regulatory system-8; sensor-like histidine kinase 3713454 cvnA8 1210618 cvnA8 Streptomyces avermitilis MA-4680 sensor-like histidine kinase NP_824138.1 3710530 R 227882 CDS NP_824139.1 29829505 1214129 3713815..3714603 1 NC_003155.4 hypothetical protein 3714603 1214129 SAV_2963 Streptomyces avermitilis MA-4680 hypothetical protein NP_824139.1 3713815 D 227882 CDS NP_824140.1 29829506 1214130 complement(3714919..3715434) 1 NC_003155.4 MarR family transcriptional regulator 3715434 1214130 SAV_2964 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_824140.1 3714919 R 227882 CDS NP_824141.1 29829507 1214131 3715703..3716521 1 NC_003155.4 PF01183: Glycosyl hydrolases family 25; lysozyme precursor 3716521 1214131 SAV_2965 Streptomyces avermitilis MA-4680 lysozyme precursor NP_824141.1 3715703 D 227882 CDS NP_824142.1 29829508 1210619 complement(3716613..3719048) 1 NC_003155.4 PF05362: Lon protease (S16) C-terminal proteolytic domain; lon class III heat-shock ATP-dependent protease 3719048 lonA 1210619 lonA Streptomyces avermitilis MA-4680 lon class III heat-shock ATP-dependent protease NP_824142.1 3716613 R 227882 CDS NP_824143.1 29829509 1214132 3719100..3719969 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; hypothetical protein 3719969 1214132 SAV_2967 Streptomyces avermitilis MA-4680 hypothetical protein NP_824143.1 3719100 D 227882 CDS NP_824144.1 29829510 1214133 complement(3720061..3721011) 1 NC_003155.4 hypothetical protein 3721011 1214133 SAV_2968 Streptomyces avermitilis MA-4680 hypothetical protein NP_824144.1 3720061 R 227882 CDS NP_824145.1 29829511 1214134 3721098..3721775 1 NC_003155.4 hypothetical protein 3721775 1214134 SAV_2969 Streptomyces avermitilis MA-4680 hypothetical protein NP_824145.1 3721098 D 227882 CDS NP_824146.1 29829512 1214135 3721889..3722626 1 NC_003155.4 two-component system response regulator 3722626 1214135 SAV_2970 Streptomyces avermitilis MA-4680 two-component system response regulator NP_824146.1 3721889 D 227882 CDS NP_824147.1 29829513 1214136 3722623..3723729 1 NC_003155.4 two-component system sensor kinase 3723729 1214136 SAV_2971 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_824147.1 3722623 D 227882 CDS NP_824148.1 29829514 1210620 3724011..3727841 1 NC_003155.4 kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; alpha-ketoglutarate decarboxylase 3727841 kgd 1210620 kgd Streptomyces avermitilis MA-4680 alpha-ketoglutarate decarboxylase NP_824148.1 3724011 D 227882 CDS NP_824149.1 29829515 1214137 complement(3727917..3731909) 1 NC_003155.4 ATP/GTP-binding protein 3731909 1214137 SAV_2973 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_824149.1 3727917 R 227882 CDS NP_824150.1 29829516 1214138 3732001..3732165 1 NC_003155.4 hypothetical protein 3732165 1214138 SAV_2974 Streptomyces avermitilis MA-4680 hypothetical protein NP_824150.1 3732001 D 227882 CDS NP_824151.1 29829517 1214139 3732202..3732525 1 NC_003155.4 hypothetical protein 3732525 1214139 SAV_2975 Streptomyces avermitilis MA-4680 hypothetical protein NP_824151.1 3732202 D 227882 CDS NP_824152.1 29829518 1214140 3732823..3733992 1 NC_003155.4 hypothetical protein 3733992 1214140 SAV_2976 Streptomyces avermitilis MA-4680 hypothetical protein NP_824152.1 3732823 D 227882 CDS NP_824153.1 29829519 1214141 3733994..3735070 1 NC_003155.4 PadR-like family transcriptional regulator 3735070 1214141 SAV_2977 Streptomyces avermitilis MA-4680 PadR-like family transcriptional regulator NP_824153.1 3733994 D 227882 CDS NP_824154.1 29829520 1214142 complement(3735319..3735885) 1 NC_003155.4 PF02861: Clp amino terminal domain; hypothetical protein 3735885 1214142 SAV_2978 Streptomyces avermitilis MA-4680 hypothetical protein NP_824154.1 3735319 R 227882 CDS NP_824155.1 29829521 1214143 complement(3735885..3736094) 1 NC_003155.4 hypothetical protein 3736094 1214143 SAV_2979 Streptomyces avermitilis MA-4680 hypothetical protein NP_824155.1 3735885 R 227882 CDS NP_824156.1 29829522 1214144 complement(3736264..3737229) 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 3737229 1214144 SAV_2980 Streptomyces avermitilis MA-4680 dehydrogenase NP_824156.1 3736264 R 227882 CDS NP_824157.1 29829523 1214145 complement(3737501..3738724) 1 NC_003155.4 PF03949: Malic enzyme, NAD binding domain; malate oxidoreductase 3738724 1214145 SAV_2981 Streptomyces avermitilis MA-4680 malate oxidoreductase NP_824157.1 3737501 R 227882 CDS NP_824158.1 29829524 1210621 3739316..3740275 1 NC_003155.4 ABC transporter periplasmic component; arginine/ornithine binding protein 3740275 aotJ 1210621 aotJ Streptomyces avermitilis MA-4680 arginine/ornithine binding protein NP_824158.1 3739316 D 227882 CDS NP_824159.1 29829525 1210622 3740309..3741247 1 NC_003155.4 ABC transporter permease; arginine/ornithine transport permease 3741247 aotM 1210622 aotM Streptomyces avermitilis MA-4680 arginine/ornithine transport permease NP_824159.1 3740309 D 227882 CDS NP_824160.1 29829526 1210623 3741244..3742035 1 NC_003155.4 ABC transporter ATP-binding protein; arginine/ornithine transport ATP-binding protein 3742035 aotP 1210623 aotP Streptomyces avermitilis MA-4680 arginine/ornithine transport ATP-binding protein NP_824160.1 3741244 D 227882 CDS NP_824161.1 29829527 1210624 complement(3742164..3742949) 1 NC_003155.4 methyltransferase 3742949 metZ 1210624 metZ Streptomyces avermitilis MA-4680 methyltransferase NP_824161.1 3742164 R 227882 CDS NP_824162.1 29829528 1214146 3743033..3743662 1 NC_003155.4 PF07336: Protein of unknown function (DUF1470); hypothetical protein 3743662 1214146 SAV_2986 Streptomyces avermitilis MA-4680 hypothetical protein NP_824162.1 3743033 D 227882 CDS NP_824163.1 29829529 1214147 complement(3743566..3744000) 1 NC_003155.4 PF00717: Peptidase S24-like; signal peptidase protein 3744000 1214147 SAV_2987 Streptomyces avermitilis MA-4680 signal peptidase protein NP_824163.1 3743566 R 227882 CDS NP_824164.1 29829530 1210625 3744146..3744541 1 NC_003155.4 Ni-containing superoxide dismutase; superoxide dismutase 3744541 sodN 1210625 sodN Streptomyces avermitilis MA-4680 superoxide dismutase NP_824164.1 3744146 D 227882 CDS NP_824165.1 29829531 1214148 complement(3744875..3745384) 1 NC_003155.4 MarR family transcriptional regulator 3745384 1214148 SAV_2989 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_824165.1 3744875 R 227882 CDS NP_824166.1 29829532 1210626 3745497..3746501 1 NC_003155.4 ptlK, probably pentalenolactone resistance gene; glyceraldehyde-3-phosphate dehydrogenase 3746501 gap1 1210626 gap1 Streptomyces avermitilis MA-4680 glyceraldehyde-3-phosphate dehydrogenase NP_824166.1 3745497 D 227882 CDS NP_824167.1 29829533 1210627 3746784..3747719 1 NC_003155.4 pentalenolactone gene cluster, PF05721: Phytanoyl-CoA dioxygenase (PhyH); hypothetical protein 3747719 ptlH 1210627 ptlH Streptomyces avermitilis MA-4680 hypothetical protein NP_824167.1 3746784 D 227882 CDS NP_824168.1 29829534 1210628 3747777..3749231 1 NC_003155.4 pentalenolactone gene cluster, PF07690: Major Facilitator Superfamily; transport protein 3749231 ptlG 1210628 ptlG Streptomyces avermitilis MA-4680 transport protein NP_824168.1 3747777 D 227882 CDS NP_824169.1 29829535 1210629 3749307..3750119 1 NC_003155.4 pentalenolactone gene cluster, PF00106: short chain dehydrogenase; oxidoreductase 3750119 ptlF 1210629 ptlF Streptomyces avermitilis MA-4680 oxidoreductase NP_824169.1 3749307 D 227882 CDS NP_824170.1 29829536 1210630 3750177..3751961 1 NC_003155.4 pentalenolactone gene cluster, PF00743: Flavin-binding monooxygenase-like; monooxygenase 3751961 ptlE 1210630 ptlE Streptomyces avermitilis MA-4680 monooxygenase NP_824170.1 3750177 D 227882 CDS NP_824171.1 29829537 1210631 3751962..3752882 1 NC_003155.4 pentalenolactone gene cluster, PF02668: Taurine catabolism dioxygenase TauD, TfdA family; dioxygenase 3752882 ptlD 1210631 ptlD Streptomyces avermitilis MA-4680 dioxygenase NP_824171.1 3751962 D 227882 CDS NP_824172.1 29829538 1210632 3752934..3753110 1 NC_003155.4 pentalenolactone gene cluster; hypothetical protein 3753110 ptlC 1210632 ptlC Streptomyces avermitilis MA-4680 hypothetical protein NP_824172.1 3752934 D 227882 CDS NP_824173.1 29829539 1210633 3753107..3754120 1 NC_003155.4 pentalenolactone gene cluster, probably farnesyl pyrophosphate synthase (idsA2); polyprenyl diphosphate synthase 3754120 ptlB 1210633 ptlB Streptomyces avermitilis MA-4680 polyprenyl diphosphate synthase NP_824173.1 3753107 D 227882 CDS NP_824174.1 29829540 1210634 3754725..3755735 1 NC_003155.4 pentalenolactone gene cluster; pentalenene synthase 3755735 ptlA 1210634 ptlA Streptomyces avermitilis MA-4680 pentalenene synthase NP_824174.1 3754725 D 227882 CDS NP_824175.1 29829541 1210635 3755792..3757141 1 NC_003155.4 cyp13, CYP183A1, pentalenolactone gene cluster; cytochrome P450 3757141 ptlI 1210635 ptlI Streptomyces avermitilis MA-4680 cytochrome P450 NP_824175.1 3755792 D 227882 CDS NP_824176.1 29829542 1210636 3757201..3757662 1 NC_003155.4 pentalenolactone gene cluster; AraC family transcription regulator 3757662 ptlR 1210636 ptlR Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_824176.1 3757201 D 227882 CDS NP_824177.1 29829543 1210637 3757659..3758093 1 NC_003155.4 pentalenolactone gene cluster; lyase 3758093 ptlJ 1210637 ptlJ Streptomyces avermitilis MA-4680 lyase NP_824177.1 3757659 D 227882 CDS NP_824178.1 29829544 1214149 3758163..3758933 1 NC_003155.4 hypothetical protein 3758933 1214149 SAV_3002 Streptomyces avermitilis MA-4680 hypothetical protein NP_824178.1 3758163 D 227882 CDS NP_824179.1 29829545 1214150 complement(3759224..3759571) 1 NC_003155.4 PF06108: Protein of unknown function (DUF952); hypothetical protein 3759571 1214150 SAV_3003 Streptomyces avermitilis MA-4680 hypothetical protein NP_824179.1 3759224 R 227882 CDS NP_824180.1 29829546 1214151 complement(3759667..3759882) 1 NC_003155.4 hypothetical protein 3759882 1214151 SAV_3004 Streptomyces avermitilis MA-4680 hypothetical protein NP_824180.1 3759667 R 227882 CDS NP_824181.1 29829547 1214152 complement(3759930..3760520) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 3760520 1214152 SAV_3005 Streptomyces avermitilis MA-4680 acetyltransferase NP_824181.1 3759930 R 227882 CDS NP_824182.1 29829548 1210638 complement(3760742..3761926) 1 NC_003155.4 probably farnesyl pyrophosphate synthase; polyprenyl diphosphate synthase 3761926 idsB 1210638 idsB Streptomyces avermitilis MA-4680 polyprenyl diphosphate synthase NP_824182.1 3760742 R 227882 CDS NP_824183.1 29829549 1210639 complement(3762063..3763469) 1 NC_003155.4 similar to sporulation-specific protein; nucleotide-binding protein 3763469 eshA 1210639 eshA Streptomyces avermitilis MA-4680 nucleotide-binding protein NP_824183.1 3762063 R 227882 CDS NP_824184.1 29829550 1214153 3764080..3764757 1 NC_003155.4 PF01510: N-acetylmuramoyl-L-alanine amidase; hypothetical protein 3764757 1214153 SAV_3008 Streptomyces avermitilis MA-4680 hypothetical protein NP_824184.1 3764080 D 227882 CDS NP_824185.1 29829551 1214154 3764786..3765721 1 NC_003155.4 1-aminocyclopropane-1-carboxylate deaminase 3765721 1214154 SAV_3009 Streptomyces avermitilis MA-4680 1-aminocyclopropane-1-carboxylate deaminase NP_824185.1 3764786 D 227882 CDS NP_824186.1 29829552 1214155 complement(3765728..3767329) 1 NC_003155.4 PF00999: Sodium/hydrogen exchanger family; sodium/proton antiporter 3767329 1214155 SAV_3010 Streptomyces avermitilis MA-4680 sodium/proton antiporter NP_824186.1 3765728 R 227882 CDS NP_824187.1 29829553 1214156 3767391..3767651 1 NC_003155.4 PF02148: Zn-finger in ubiquitin-hydrolases and other protein; hypothetical protein 3767651 1214156 SAV_3011 Streptomyces avermitilis MA-4680 hypothetical protein NP_824187.1 3767391 D 227882 CDS NP_824188.1 29829554 1210640 3767924..3768337 1 NC_003155.4 rshA; anti-sigma factor 3768337 rsbW 1210640 rsbW Streptomyces avermitilis MA-4680 anti-sigma factor NP_824188.1 3767924 D 227882 CDS NP_824189.1 29829555 1210641 3768334..3769509 1 NC_003155.4 RNA polymerase alternative sigma factor; RNA polymerase sigma factor, sigH 3769509 sig21 1210641 sig21 Streptomyces avermitilis MA-4680 RNA polymerase sigma factor, sigH NP_824189.1 3768334 D 227882 CDS NP_824190.1 29829556 1214157 complement(3769563..3770036) 1 NC_003155.4 integral membrane protein 3770036 1214157 SAV_3014 Streptomyces avermitilis MA-4680 integral membrane protein NP_824190.1 3769563 R 227882 CDS NP_824191.1 29829557 1214158 3770150..3771118 1 NC_003155.4 PF00781: Diacylglycerol kinase catalytic domain (presumed); hypothetical protein 3771118 1214158 SAV_3015 Streptomyces avermitilis MA-4680 hypothetical protein NP_824191.1 3770150 D 227882 CDS NP_824192.1 29829558 1210642 3771438..3771695 1 NC_003155.4 PF02467: Transcription factor WhiB; WhiB-family transcriptional regulator 3771695 wblE 1210642 wblE Streptomyces avermitilis MA-4680 WhiB-family transcriptional regulator NP_824192.1 3771438 D 227882 CDS NP_824193.1 29829559 1214159 complement(3771944..3773449) 1 NC_003155.4 two-component system sensor kinase 3773449 1214159 SAV_3017 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_824193.1 3771944 R 227882 CDS NP_824194.1 29829560 1210643 3773972..3774757 1 NC_003155.4 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase 3774757 nagB 1210643 nagB Streptomyces avermitilis MA-4680 glucosamine-6-phosphate deaminase NP_824194.1 3773972 D 227882 CDS NP_824195.1 29829561 1214160 complement(3774850..3776454) 1 NC_003155.4 beta-N-acetylhexosaminidase 3776454 nagZ1 1214160 nagZ1 Streptomyces avermitilis MA-4680 beta-N-acetylhexosaminidase NP_824195.1 3774850 R 227882 CDS NP_824196.1 29829562 1214161 complement(3776463..3777305) 1 NC_003155.4 sugar ABC transporter permease 3777305 1214161 SAV_3020 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_824196.1 3776463 R 227882 CDS NP_824197.1 29829563 1214162 complement(3777302..3778291) 1 NC_003155.4 sugar ABC transporter permease 3778291 1214162 SAV_3021 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_824197.1 3777302 R 227882 CDS NP_824198.1 29829564 1214163 complement(3778407..3779726) 1 NC_003155.4 sugar ABC transporter substrate-binding protein 3779726 1214163 SAV_3022 Streptomyces avermitilis MA-4680 sugar ABC transporter substrate-binding protein NP_824198.1 3778407 R 227882 CDS NP_824199.1 29829565 1214164 3780104..3780868 1 NC_003155.4 PF07702: UbiC transcription regulator-associated; GntR family transcriptional regulator 3780868 1214164 SAV_3023 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_824199.1 3780104 D 227882 CDS NP_824200.1 29829566 1214165 3781105..3781359 1 NC_003155.4 hypothetical protein 3781359 1214165 SAV_3024 Streptomyces avermitilis MA-4680 hypothetical protein NP_824200.1 3781105 D 227882 CDS NP_824201.1 29829567 1214166 3781368..3782984 1 NC_003155.4 PF00474: Sodium:solute symporter family; sodium/proline symporter 3782984 1214166 SAV_3025 Streptomyces avermitilis MA-4680 sodium/proline symporter NP_824201.1 3781368 D 227882 CDS NP_824202.1 29829568 1210644 3783420..3785801 1 NC_003155.4 ribonucleoside-diphosphate reductase alpha chain 3785801 nrdL 1210644 nrdL Streptomyces avermitilis MA-4680 ribonucleoside-diphosphate reductase alpha chain NP_824202.1 3783420 D 227882 CDS NP_824203.1 29829569 1210645 3785798..3786814 1 NC_003155.4 ribonucleoside-diphosphate reductase beta chain 3786814 nrdM 1210645 nrdM Streptomyces avermitilis MA-4680 ribonucleoside-diphosphate reductase beta chain NP_824203.1 3785798 D 227882 CDS NP_824204.1 29829570 1214167 3786909..3787418 1 NC_003155.4 hypothetical protein 3787418 1214167 SAV_3028 Streptomyces avermitilis MA-4680 hypothetical protein NP_824204.1 3786909 D 227882 CDS NP_824205.1 29829571 1214168 complement(3787379..3787609) 1 NC_003155.4 hypothetical protein 3787609 1214168 SAV_3029 Streptomyces avermitilis MA-4680 hypothetical protein NP_824205.1 3787379 R 227882 CDS NP_824206.1 29829572 1214169 3787680..3788660 1 NC_003155.4 AraC family transcription regulator 3788660 1214169 SAV_3030 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_824206.1 3787680 D 227882 CDS NP_824207.1 29829573 1210646 complement(3788761..3790131) 1 NC_003155.4 CYP170A2; cytochrome P450 hydroxylase 3790131 cyp14 1210646 cyp14 Streptomyces avermitilis MA-4680 cytochrome P450 hydroxylase NP_824207.1 3788761 R 227882 CDS NP_824208.1 29829574 1210647 complement(3790128..3791219) 1 NC_003155.4 terpene biosynthesis; terpene cyclase 3791219 tpc2 1210647 tpc2 Streptomyces avermitilis MA-4680 terpene cyclase NP_824208.1 3790128 R 227882 CDS NP_824209.1 29829575 1210648 complement(3791551..3792201) 1 NC_003155.4 polypeptide deformylase 3792201 def1 1210648 def1 Streptomyces avermitilis MA-4680 polypeptide deformylase NP_824209.1 3791551 R 227882 CDS NP_824210.1 29829576 1214170 complement(3792275..3793255) 1 NC_003155.4 hypothetical protein 3793255 1214170 SAV_3034 Streptomyces avermitilis MA-4680 hypothetical protein NP_824210.1 3792275 R 227882 CDS NP_824211.1 29829577 1214171 complement(3793397..3794725) 1 NC_003155.4 PF01966: HD domain; lipoprotein 3794725 1214171 SAV_3035 Streptomyces avermitilis MA-4680 lipoprotein NP_824211.1 3793397 R 227882 CDS NP_824212.1 29829578 1214172 complement(3794722..3796161) 1 NC_003155.4 PF01966: HD domain; hypothetical protein 3796161 1214172 SAV_3036 Streptomyces avermitilis MA-4680 hypothetical protein NP_824212.1 3794722 R 227882 CDS NP_824213.1 29829579 1214173 complement(3796337..3796648) 1 NC_003155.4 anti-sigma factor 3796648 1214173 SAV_3037 Streptomyces avermitilis MA-4680 anti-sigma factor NP_824213.1 3796337 R 227882 CDS NP_824214.1 29829580 1210649 complement(3796645..3797328) 1 NC_003155.4 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 3797328 sig22 1210649 sig22 Streptomyces avermitilis MA-4680 RNA polymerase sigma factor RpoE NP_824214.1 3796645 R 227882 CDS NP_824215.1 29829581 1214174 complement(3797574..3798209) 1 NC_003155.4 hypothetical protein 3798209 1214174 SAV_3039 Streptomyces avermitilis MA-4680 hypothetical protein NP_824215.1 3797574 R 227882 CDS NP_824216.1 29829582 1214175 complement(3798211..3799050) 1 NC_003155.4 PF02586: Uncharacterised ACR, COG2135; hypothetical protein 3799050 1214175 SAV_3040 Streptomyces avermitilis MA-4680 hypothetical protein NP_824216.1 3798211 R 227882 CDS NP_824217.1 29829583 1214176 3799157..3799888 1 NC_003155.4 integral membrane protein 3799888 1214176 SAV_3041 Streptomyces avermitilis MA-4680 integral membrane protein NP_824217.1 3799157 D 227882 CDS NP_824218.1 29829584 1210650 3800068..3801408 1 NC_003155.4 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 3801408 aroA 1210650 aroA Streptomyces avermitilis MA-4680 3-phosphoshikimate 1-carboxyvinyltransferase NP_824218.1 3800068 D 227882 CDS NP_824219.1 29829585 1214177 3801425..3802435 1 NC_003155.4 PF03193: Protein of unknown function, DUF258; hypothetical protein 3802435 1214177 SAV_3043 Streptomyces avermitilis MA-4680 hypothetical protein NP_824219.1 3801425 D 227882 CDS NP_824220.1 29829586 1214178 3802556..3802879 1 NC_003155.4 SMR-type multi-drug efflux transporter 3802879 sugE 1214178 sugE Streptomyces avermitilis MA-4680 SMR-type multi-drug efflux transporter NP_824220.1 3802556 D 227882 CDS NP_824221.1 29829587 1214179 complement(3802902..3804689) 1 NC_003155.4 ABC transporter ATP-binding protein 3804689 1214179 SAV_3045 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_824221.1 3802902 R 227882 CDS NP_824222.1 29829588 1210651 complement(3804695..3805603) 1 NC_003155.4 PF00528: Binding-protein-dependent transport system inner membrane component; peptide ABC transporter permease 3805603 oppC1 1210651 oppC1 Streptomyces avermitilis MA-4680 peptide ABC transporter permease NP_824222.1 3804695 R 227882 CDS NP_824223.1 29829589 1210652 complement(3805600..3806595) 1 NC_003155.4 peptide ABC transporter permease 3806595 oppB1 1210652 oppB1 Streptomyces avermitilis MA-4680 peptide ABC transporter permease NP_824223.1 3805600 R 227882 CDS NP_824224.1 29829590 1210653 3806749..3808437 1 NC_003155.4 extracellular solute-binding dependent transport lipoprotein 3808437 oppA1 1210653 oppA1 Streptomyces avermitilis MA-4680 extracellular solute-binding dependent transport lipoprotein NP_824224.1 3806749 D 227882 CDS NP_824225.1 29829591 1214180 complement(3808424..3809056) 1 NC_003155.4 TetR family transcriptional regulator 3809056 1214180 SAV_3049 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_824225.1 3808424 R 227882 CDS NP_824226.1 29829592 1214181 3809245..3810045 1 NC_003155.4 fructose-1,6-bisphosphatase 3810045 1214181 SAV_3050 Streptomyces avermitilis MA-4680 fructose-1,6-bisphosphatase NP_824226.1 3809245 D 227882 CDS NP_824227.1 29829593 1214182 3810212..3810604 1 NC_003155.4 PF00571: CBS domain; hypothetical protein 3810604 1214182 SAV_3051 Streptomyces avermitilis MA-4680 hypothetical protein NP_824227.1 3810212 D 227882 CDS NP_824228.1 29829594 1210654 complement(3810692..3812143) 1 NC_003155.4 catalase 3812143 katA1 1210654 katA1 Streptomyces avermitilis MA-4680 catalase NP_824228.1 3810692 R 227882 CDS NP_824229.1 29829595 1210655 3812287..3812703 1 NC_003155.4 hydrogen peroxide sensitive repressor 3812703 catR 1210655 catR Streptomyces avermitilis MA-4680 hydrogen peroxide sensitive repressor NP_824229.1 3812287 D 227882 CDS NP_824230.1 29829596 1214183 complement(3813377..3815227) 1 NC_003155.4 PF00515: TPR Domain; hypothetical protein 3815227 1214183 SAV_3054 Streptomyces avermitilis MA-4680 hypothetical protein NP_824230.1 3813377 R 227882 CDS NP_824231.1 29829597 1214184 complement(3815575..3818571) 1 NC_003155.4 PF03699: Uncharacterised protein family (UPF0182); integral membrane protein 3818571 1214184 SAV_3055 Streptomyces avermitilis MA-4680 integral membrane protein NP_824231.1 3815575 R 227882 CDS NP_824232.1 29829598 1214185 3818730..3819278 1 NC_003155.4 hypothetical protein 3819278 1214185 SAV_3056 Streptomyces avermitilis MA-4680 hypothetical protein NP_824232.1 3818730 D 227882 CDS NP_824233.1 29829599 1214186 complement(3819427..3820524) 1 NC_003155.4 PF00595: PDZ domain (Also known as DHR or GLGF); protein 3820524 1214186 SAV_3057 Streptomyces avermitilis MA-4680 protein NP_824233.1 3819427 R 227882 CDS NP_824234.1 29829600 1214187 complement(3820609..3820773) 1 NC_003155.4 hypothetical protein 3820773 1214187 SAV_3058 Streptomyces avermitilis MA-4680 hypothetical protein NP_824234.1 3820609 R 227882 CDS NP_824235.1 29829601 1210658 complement(3820914..3821375) 1 NC_003155.4 molybdopterin biosynthesis protein E 3821375 moaE 1210658 moaE Streptomyces avermitilis MA-4680 molybdopterin biosynthesis protein E NP_824235.1 3820914 R 227882 CDS NP_824236.1 29829602 1214188 complement(3821579..3822691) 1 NC_003155.4 PF01370: NAD dependent epimerase/dehydratase family; hypothetical protein 3822691 1214188 SAV_3060 Streptomyces avermitilis MA-4680 hypothetical protein NP_824236.1 3821579 R 227882 CDS NP_824237.1 29829603 1214189 3822882..3824333 1 NC_003155.4 hypothetical protein 3824333 1214189 SAV_3061 Streptomyces avermitilis MA-4680 hypothetical protein NP_824237.1 3822882 D 227882 CDS NP_824238.1 29829604 1214190 3824330..3824851 1 NC_003155.4 PF00293: NUDIX domain; hypothetical protein 3824851 1214190 SAV_3062 Streptomyces avermitilis MA-4680 hypothetical protein NP_824238.1 3824330 D 227882 CDS NP_824239.1 29829605 1214191 complement(3824933..3825688) 1 NC_003155.4 PF01987: Protein of unknown function DUF124; hypothetical protein 3825688 1214191 SAV_3063 Streptomyces avermitilis MA-4680 hypothetical protein NP_824239.1 3824933 R 227882 CDS NP_824240.1 29829606 1214192 complement(3825705..3826385) 1 NC_003155.4 PF01987: Protein of unknown function DUF124; hypothetical protein 3826385 1214192 SAV_3064 Streptomyces avermitilis MA-4680 hypothetical protein NP_824240.1 3825705 R 227882 CDS NP_824241.1 29829607 1214193 complement(3826397..3828073) 1 NC_003155.4 PF01987: Protein of unknown function DUF124; hypothetical protein 3828073 1214193 SAV_3065 Streptomyces avermitilis MA-4680 hypothetical protein NP_824241.1 3826397 R 227882 CDS NP_824242.1 29829608 1214194 complement(3828199..3828642) 1 NC_003155.4 PF01863: Protein of unknown function DUF45; hypothetical protein 3828642 1214194 SAV_3066 Streptomyces avermitilis MA-4680 hypothetical protein NP_824242.1 3828199 R 227882 CDS NP_824243.1 29829609 1214195 3829013..3830236 1 NC_003155.4 PF00899: ThiF family; hypothetical protein 3830236 1214195 SAV_3067 Streptomyces avermitilis MA-4680 hypothetical protein NP_824243.1 3829013 D 227882 CDS NP_824244.1 29829610 1214196 3830229..3831584 1 NC_003155.4 ABC transporter ATP-binding protein 3831584 1214196 SAV_3068 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_824244.1 3830229 D 227882 CDS NP_824245.1 29829611 1214197 complement(3831857..3832180) 1 NC_003155.4 hypothetical protein 3832180 1214197 SAV_3069 Streptomyces avermitilis MA-4680 hypothetical protein NP_824245.1 3831857 R 227882 CDS NP_824246.1 29829612 1214198 complement(3832177..3832545) 1 NC_003155.4 WhiB-family transcriptional regulator 3832545 1214198 SAV_3070 Streptomyces avermitilis MA-4680 WhiB-family transcriptional regulator NP_824246.1 3832177 R 227882 CDS NP_824247.1 29829613 1214199 complement(3832722..3833069) 1 NC_003155.4 hypothetical protein 3833069 1214199 SAV_3071 Streptomyces avermitilis MA-4680 hypothetical protein NP_824247.1 3832722 R 227882 CDS NP_824248.1 29829614 1210659 complement(3833208..3835520) 1 NC_003155.4 ATP-dependent DNA helicase 3835520 uvrD4 1210659 uvrD4 Streptomyces avermitilis MA-4680 ATP-dependent DNA helicase NP_824248.1 3833208 R 227882 CDS NP_824249.1 29829615 1214200 3835666..3835908 1 NC_003155.4 glutaredoxin-like protein 3835908 1214200 SAV_3073 Streptomyces avermitilis MA-4680 glutaredoxin-like protein NP_824249.1 3835666 D 227882 CDS NP_824250.1 29829616 1214201 complement(3836030..3836977) 1 NC_003155.4 PF00293: NUDIX domain; hypothetical protein 3836977 1214201 SAV_3074 Streptomyces avermitilis MA-4680 hypothetical protein NP_824250.1 3836030 R 227882 CDS NP_824251.1 29829617 1214202 complement(3837142..3838545) 1 NC_003155.4 PF01546: Peptidase family M20/M25/M40; peptidase 3838545 1214202 SAV_3075 Streptomyces avermitilis MA-4680 peptidase NP_824251.1 3837142 R 227882 CDS NP_824252.1 29829618 1210660 complement(3838556..3842164) 1 NC_003155.4 ATP-dependent DNA helicase 3842164 uvrD3 1210660 uvrD3 Streptomyces avermitilis MA-4680 ATP-dependent DNA helicase NP_824252.1 3838556 R 227882 CDS NP_824253.1 29829619 1210661 complement(3842216..3845605) 1 NC_003155.4 ATP-dependent DNA helicase 3845605 uvrD2 1210661 uvrD2 Streptomyces avermitilis MA-4680 ATP-dependent DNA helicase NP_824253.1 3842216 R 227882 CDS NP_824254.1 29829620 1214203 complement(3845872..3846345) 1 NC_003155.4 PF01035: 6-O-methylguanine DNA methyltransferase, DNA binding domain; hypothetical protein 3846345 1214203 SAV_3078 Streptomyces avermitilis MA-4680 hypothetical protein NP_824254.1 3845872 R 227882 CDS NP_824255.1 29829621 1214204 3846424..3849318 1 NC_003155.4 PF03706: Uncharacterised protein family (UPF0104); integral membrane protein 3849318 1214204 SAV_3079 Streptomyces avermitilis MA-4680 integral membrane protein NP_824255.1 3846424 D 227882 CDS NP_824256.1 29829622 1214205 3849387..3850937 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; protease 3850937 1214205 SAV_3080 Streptomyces avermitilis MA-4680 protease NP_824256.1 3849387 D 227882 CDS NP_824257.1 29829623 1214206 3851057..3852610 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; protease 3852610 1214206 SAV_3081 Streptomyces avermitilis MA-4680 protease NP_824257.1 3851057 D 227882 CDS NP_824258.1 29829624 1214207 complement(3852673..3853851) 1 NC_003155.4 The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; molybdopterin biosynthesis-like protein MoeZ 3853851 1214207 SAV_3082 Streptomyces avermitilis MA-4680 molybdopterin biosynthesis-like protein MoeZ NP_824258.1 3852673 R 227882 CDS NP_824259.1 29829625 1214208 complement(3853915..3854664) 1 NC_003155.4 hypothetical protein 3854664 1214208 SAV_3083 Streptomyces avermitilis MA-4680 hypothetical protein NP_824259.1 3853915 R 227882 CDS NP_824260.1 29829626 1214209 complement(3854652..3855611) 1 NC_003155.4 NDP-hexose 4-ketoreductase 3855611 1214209 SAV_3084 Streptomyces avermitilis MA-4680 NDP-hexose 4-ketoreductase NP_824260.1 3854652 R 227882 CDS NP_824261.1 29829627 1214210 complement(3855812..3856843) 1 NC_003155.4 hypothetical protein 3856843 1214210 SAV_3085 Streptomyces avermitilis MA-4680 hypothetical protein NP_824261.1 3855812 R 227882 CDS NP_824262.1 29829628 1214211 complement(3857047..3858975) 1 NC_003155.4 glycosyltransferase 3858975 1214211 SAV_3086 Streptomyces avermitilis MA-4680 glycosyltransferase NP_824262.1 3857047 R 227882 CDS NP_824263.1 29829629 1214212 complement(3859166..3860767) 1 NC_003155.4 ABC transporter ATP-binding protein 3860767 1214212 SAV_3087 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_824263.1 3859166 R 227882 CDS NP_824264.1 29829630 1214213 complement(3860764..3861762) 1 NC_003155.4 oligopeptide transport; ABC transporter 3861762 1214213 SAV_3088 Streptomyces avermitilis MA-4680 ABC transporter NP_824264.1 3860764 R 227882 CDS NP_824265.1 29829631 1214214 complement(3861759..3862841) 1 NC_003155.4 oligopeptide transport; ABC transporter 3862841 1214214 SAV_3089 Streptomyces avermitilis MA-4680 ABC transporter NP_824265.1 3861759 R 227882 CDS NP_824266.1 29829632 1214215 complement(3862846..3864564) 1 NC_003155.4 oligopeptide transport; ABC transporter substrate-binding protein 3864564 1214215 SAV_3090 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_824266.1 3862846 R 227882 CDS NP_824267.1 29829633 1214216 complement(3864860..3866410) 1 NC_003155.4 hypothetical protein 3866410 1214216 SAV_3091 Streptomyces avermitilis MA-4680 hypothetical protein NP_824267.1 3864860 R 227882 CDS NP_824268.1 29829634 1214217 complement(3866419..3867456) 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 3867456 1214217 SAV_3092 Streptomyces avermitilis MA-4680 hydrolase NP_824268.1 3866419 R 227882 CDS NP_824269.1 29829635 1214218 3867692..3867913 1 NC_003155.4 hypothetical protein 3867913 1214218 SAV_3093 Streptomyces avermitilis MA-4680 hypothetical protein NP_824269.1 3867692 D 227882 CDS NP_824270.1 29829636 1214219 3868223..3868864 1 NC_003155.4 TetR family transcriptional regulator 3868864 1214219 SAV_3094 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_824270.1 3868223 D 227882 CDS NP_824271.1 29829637 1214220 3868964..3869248 1 NC_003155.4 hypothetical protein 3869248 1214220 SAV_3095 Streptomyces avermitilis MA-4680 hypothetical protein NP_824271.1 3868964 D 227882 CDS NP_824272.1 29829638 1214221 3869353..3869706 1 NC_003155.4 hypothetical protein 3869706 1214221 SAV_3096 Streptomyces avermitilis MA-4680 hypothetical protein NP_824272.1 3869353 D 227882 CDS NP_824273.1 29829639 1214222 complement(3869891..3870637) 1 NC_003155.4 hypothetical protein 3870637 1214222 SAV_3097 Streptomyces avermitilis MA-4680 hypothetical protein NP_824273.1 3869891 R 227882 CDS NP_824274.1 29829640 1210662 3871098..3873377 1 NC_003155.4 PF00270: DEAD/DEAH box helicase; ATP-dependent RNA helicase 3873377 rhlE 1210662 rhlE Streptomyces avermitilis MA-4680 ATP-dependent RNA helicase NP_824274.1 3871098 D 227882 CDS NP_824275.1 29829641 1214223 3873623..3874495 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 3874495 1214223 SAV_3099 Streptomyces avermitilis MA-4680 hydrolase NP_824275.1 3873623 D 227882 CDS NP_824276.1 29829642 1214224 complement(3874618..3875514) 1 NC_003155.4 hypothetical protein 3875514 1214224 SAV_3100 Streptomyces avermitilis MA-4680 hypothetical protein NP_824276.1 3874618 R 227882 CDS NP_824277.1 29829643 1214225 3875749..3875925 1 NC_003155.4 hypothetical protein 3875925 1214225 SAV_3101 Streptomyces avermitilis MA-4680 hypothetical protein NP_824277.1 3875749 D 227882 CDS NP_824278.1 29829644 1214226 complement(3876042..3876647) 1 NC_003155.4 PF01914: MarC family integral membrane protein; integral membrane protein 3876647 1214226 SAV_3102 Streptomyces avermitilis MA-4680 integral membrane protein NP_824278.1 3876042 R 227882 CDS NP_824279.1 29829645 1214227 complement(3876807..3877673) 1 NC_003155.4 PF02231: PHP domain N-terminal region; hypothetical protein 3877673 1214227 SAV_3103 Streptomyces avermitilis MA-4680 hypothetical protein NP_824279.1 3876807 R 227882 CDS NP_824280.1 29829646 1214228 complement(3877876..3878517) 1 NC_003155.4 hypothetical protein 3878517 1214228 SAV_3104 Streptomyces avermitilis MA-4680 hypothetical protein NP_824280.1 3877876 R 227882 CDS NP_824281.1 29829647 1214229 complement(3878805..3878993) 1 NC_003155.4 hypothetical protein 3878993 1214229 SAV_3105 Streptomyces avermitilis MA-4680 hypothetical protein NP_824281.1 3878805 R 227882 CDS NP_824282.1 29829648 1214230 complement(3879026..3879610) 1 NC_003155.4 hypothetical protein 3879610 1214230 SAV_3106 Streptomyces avermitilis MA-4680 hypothetical protein NP_824282.1 3879026 R 227882 CDS NP_824283.1 29829649 1214231 3880153..3881268 1 NC_003155.4 metal-transport protein 3881268 corA2 1214231 corA2 Streptomyces avermitilis MA-4680 metal-transport protein NP_824283.1 3880153 D 227882 CDS NP_824284.1 29829650 1214232 3881292..3881834 1 NC_003155.4 hypothetical protein 3881834 1214232 SAV_3108 Streptomyces avermitilis MA-4680 hypothetical protein NP_824284.1 3881292 D 227882 CDS NP_824285.1 29829651 1214233 complement(3882041..3882805) 1 NC_003155.4 lipoprotein 3882805 1214233 SAV_3109 Streptomyces avermitilis MA-4680 lipoprotein NP_824285.1 3882041 R 227882 CDS NP_824286.1 29829652 1214234 3883056..3884354 1 NC_003155.4 magnesium (Mg2+) transporter 3884354 1214234 SAV_3110 Streptomyces avermitilis MA-4680 magnesium (Mg2+) transporter NP_824286.1 3883056 D 227882 CDS NP_824287.1 29829653 1214235 3884344..3884940 1 NC_003155.4 PF06210: Protein of unknown function (DUF1003); hypothetical protein 3884940 1214235 SAV_3111 Streptomyces avermitilis MA-4680 hypothetical protein NP_824287.1 3884344 D 227882 CDS NP_824288.1 29829654 1214236 3884984..3886117 1 NC_003155.4 ATP-binding protein 3886117 1214236 SAV_3112 Streptomyces avermitilis MA-4680 ATP-binding protein NP_824288.1 3884984 D 227882 CDS NP_824289.1 29829655 1214237 complement(3886257..3886991) 1 NC_003155.4 hypothetical protein 3886991 1214237 SAV_3113 Streptomyces avermitilis MA-4680 hypothetical protein NP_824289.1 3886257 R 227882 CDS NP_824290.1 29829656 1214238 complement(3887259..3887705) 1 NC_003155.4 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 3887705 1214238 SAV_3114 Streptomyces avermitilis MA-4680 sec-independent translocase NP_824290.1 3887259 R 227882 CDS NP_824291.1 29829657 1214239 complement(3887910..3889769) 1 NC_003155.4 PF00089: Trypsin; serine protease 3889769 1214239 SAV_3115 Streptomyces avermitilis MA-4680 serine protease NP_824291.1 3887910 R 227882 CDS NP_824292.1 29829658 1214240 complement(3890222..3891226) 1 NC_003155.4 hypothetical protein 3891226 1214240 SAV_3116 Streptomyces avermitilis MA-4680 hypothetical protein NP_824292.1 3890222 R 227882 CDS NP_824293.1 29829659 1210663 complement(3891223..3891882) 1 NC_003155.4 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein is involved in heat shock, oxidative stress and virulence; RNA polymerase sigma factor SigE 3891882 sig23 1210663 sig23 Streptomyces avermitilis MA-4680 RNA polymerase sigma factor SigE NP_824293.1 3891223 R 227882 CDS NP_824294.1 29829660 1214241 3892325..3892849 1 NC_003155.4 O-methyltransferase 3892849 1214241 SAV_3118 Streptomyces avermitilis MA-4680 O-methyltransferase NP_824294.1 3892325 D 227882 CDS NP_824295.1 29829661 1214242 complement(3893015..3893260) 1 NC_003155.4 hypothetical protein 3893260 1214242 SAV_3119 Streptomyces avermitilis MA-4680 hypothetical protein NP_824295.1 3893015 R 227882 CDS NP_824296.1 29829662 1214243 3893559..3894362 1 NC_003155.4 enoyl-CoA hydratase/isomerase 3894362 1214243 SAV_3120 Streptomyces avermitilis MA-4680 enoyl-CoA hydratase/isomerase NP_824296.1 3893559 D 227882 CDS NP_824297.1 29829663 1210664 complement(3894382..3894963) 1 NC_003155.4 DNA-3-methyladenine glycosylase I 3894963 tagA 1210664 tagA Streptomyces avermitilis MA-4680 DNA-3-methyladenine glycosylase I NP_824297.1 3894382 R 227882 CDS NP_824298.1 29829664 1214244 complement(3894960..3895316) 1 NC_003155.4 protein 3895316 1214244 SAV_3122 Streptomyces avermitilis MA-4680 protein NP_824298.1 3894960 R 227882 CDS NP_824299.1 29829665 1210665 3895549..3896409 1 NC_003155.4 dihydropteroate synthase 3896409 folP1 1210665 folP1 Streptomyces avermitilis MA-4680 dihydropteroate synthase NP_824299.1 3895549 D 227882 CDS NP_824300.1 29829666 1214245 complement(3896455..3897213) 1 NC_003155.4 PF03641: Possible lysine decarboxylase; hypothetical protein 3897213 1214245 SAV_3124 Streptomyces avermitilis MA-4680 hypothetical protein NP_824300.1 3896455 R 227882 CDS NP_824301.1 29829667 1210666 complement(3897321..3898400) 1 NC_003155.4 catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate; succinyl-diaminopimelate desuccinylase 3898400 dapE 1210666 dapE Streptomyces avermitilis MA-4680 succinyl-diaminopimelate desuccinylase NP_824301.1 3897321 R 227882 CDS NP_824302.1 29829668 1214246 3898600..3899463 1 NC_003155.4 hypothetical protein 3899463 1214246 SAV_3126 Streptomyces avermitilis MA-4680 hypothetical protein NP_824302.1 3898600 D 227882 CDS NP_824303.1 29829669 1214247 3899804..3900253 1 NC_003155.4 ATP-binding protein 3900253 1214247 SAV_3127 Streptomyces avermitilis MA-4680 ATP-binding protein NP_824303.1 3899804 D 227882 CDS NP_824304.1 29829670 1214248 complement(3900319..3901413) 1 NC_003155.4 catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis; N-succinyldiaminopimelate aminotransferase 3901413 aspB2 1214248 aspB2 Streptomyces avermitilis MA-4680 N-succinyldiaminopimelate aminotransferase NP_824304.1 3900319 R 227882 CDS NP_824305.1 29829671 1210667 complement(3901642..3901962) 1 NC_003155.4 ferredoxin 3901962 fdxD 1210667 fdxD Streptomyces avermitilis MA-4680 ferredoxin NP_824305.1 3901642 R 227882 CDS NP_824306.1 29829672 1214249 3902103..3903476 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 3903476 1214249 SAV_3130 Streptomyces avermitilis MA-4680 acetyltransferase NP_824306.1 3902103 D 227882 CDS NP_824307.1 29829673 1214250 3903473..3904345 1 NC_003155.4 hypothetical protein 3904345 1214250 SAV_3131 Streptomyces avermitilis MA-4680 hypothetical protein NP_824307.1 3903473 D 227882 CDS NP_824308.1 29829674 1214251 complement(3904364..3904978) 1 NC_003155.4 two-component system response regulator 3904978 1214251 SAV_3132 Streptomyces avermitilis MA-4680 two-component system response regulator NP_824308.1 3904364 R 227882 CDS NP_824309.1 29829675 1214252 complement(3904989..3906146) 1 NC_003155.4 two-component system sensor kinase 3906146 1214252 SAV_3133 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_824309.1 3904989 R 227882 CDS NP_824310.1 29829676 1214253 complement(3906197..3906955) 1 NC_003155.4 ABC transporter permease 3906955 1214253 SAV_3134 Streptomyces avermitilis MA-4680 ABC transporter permease NP_824310.1 3906197 R 227882 CDS NP_824311.1 29829677 1214254 complement(3906952..3907860) 1 NC_003155.4 ABC transporter ATP-binding protein 3907860 1214254 SAV_3135 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_824311.1 3906952 R 227882 CDS NP_824312.1 29829678 1214255 complement(3908162..3910441) 1 NC_003155.4 hypothetical protein 3910441 1214255 SAV_3136 Streptomyces avermitilis MA-4680 hypothetical protein NP_824312.1 3908162 R 227882 CDS NP_824313.1 29829679 1214256 complement(3910607..3911026) 1 NC_003155.4 integral membrane protein 3911026 1214256 SAV_3137 Streptomyces avermitilis MA-4680 integral membrane protein NP_824313.1 3910607 R 227882 CDS NP_824314.1 29829680 1214257 complement(3911026..3911910) 1 NC_003155.4 mycothiol biosynthesis; N-acetyl-1-D-myo-inosityl-2-amino-2- deoxy-alpha-D-glucopyranoside deacetylase 3911910 mshB 1214257 mshB Streptomyces avermitilis MA-4680 N-acetyl-1-D-myo-inosityl-2-amino-2- deoxy-alpha-D-glucopyranoside deacetylase NP_824314.1 3911026 R 227882 CDS NP_824315.1 29829681 1214258 complement(3912070..3912966) 1 NC_003155.4 hypothetical protein 3912966 1214258 SAV_3139 Streptomyces avermitilis MA-4680 hypothetical protein NP_824315.1 3912070 R 227882 CDS NP_824316.1 29829682 1214259 complement(3913164..3913658) 1 NC_003155.4 regulatory protein 3913658 1214259 SAV_3140 Streptomyces avermitilis MA-4680 regulatory protein NP_824316.1 3913164 R 227882 CDS NP_824317.1 29829683 1214260 3913789..3914658 1 NC_003155.4 DNA-binding protein 3914658 1214260 SAV_3141 Streptomyces avermitilis MA-4680 DNA-binding protein NP_824317.1 3913789 D 227882 CDS NP_824318.1 29829684 1214261 3914655..3914867 1 NC_003155.4 PF04149: Domain of unknown function (DUF397); hypothetical protein 3914867 1214261 SAV_3142 Streptomyces avermitilis MA-4680 hypothetical protein NP_824318.1 3914655 D 227882 CDS NP_824319.1 29829685 1214262 complement(3914978..3915172) 1 NC_003155.4 protein 3915172 1214262 SAV_3143 Streptomyces avermitilis MA-4680 protein NP_824319.1 3914978 R 227882 CDS NP_824320.1 29829686 1214263 3915360..3917492 1 NC_003155.4 PF00326: Prolyl oligopeptidase family; peptidase 3917492 1214263 SAV_3144 Streptomyces avermitilis MA-4680 peptidase NP_824320.1 3915360 D 227882 CDS NP_824321.1 29829687 1214264 complement(3917642..3918727) 1 NC_003155.4 peptide ABC transporter ATP-binding protein 3918727 1214264 SAV_3145 Streptomyces avermitilis MA-4680 peptide ABC transporter ATP-binding protein NP_824321.1 3917642 R 227882 CDS NP_824322.1 29829688 1210668 complement(3918720..3919703) 1 NC_003155.4 peptide ABC transporter ATP-binding protein 3919703 dppD 1210668 dppD Streptomyces avermitilis MA-4680 peptide ABC transporter ATP-binding protein NP_824322.1 3918720 R 227882 CDS NP_824323.1 29829689 1210669 complement(3919711..3920631) 1 NC_003155.4 oligopeptide ABC transporter permease 3920631 oppC2 1210669 oppC2 Streptomyces avermitilis MA-4680 oligopeptide ABC transporter permease NP_824323.1 3919711 R 227882 CDS NP_824324.1 29829690 1210670 complement(3920681..3921604) 1 NC_003155.4 oligopeptide ABC transporter substrate-binding protein 3921604 oppB2 1210670 oppB2 Streptomyces avermitilis MA-4680 oligopeptide ABC transporter substrate-binding protein NP_824324.1 3920681 R 227882 CDS NP_824325.1 29829691 1210671 complement(3921659..3923281) 1 NC_003155.4 oligopeptide ABC transporter substrate-binding protein 3923281 oppA2 1210671 oppA2 Streptomyces avermitilis MA-4680 oligopeptide ABC transporter substrate-binding protein NP_824325.1 3921659 R 227882 CDS NP_824326.1 29829692 1210672 3923776..3924765 1 NC_003155.4 ABC transporter periplasmic component; ABC transporter permease 3924765 bldKA1 1210672 bldKA1 Streptomyces avermitilis MA-4680 ABC transporter permease NP_824326.1 3923776 D 227882 CDS NP_824327.1 29829693 1210673 3924847..3926610 1 NC_003155.4 ABC transporter periplasmic component; ABC transporter 3926610 bldKB1 1210673 bldKB1 Streptomyces avermitilis MA-4680 ABC transporter NP_824327.1 3924847 D 227882 CDS NP_824328.1 29829694 1210674 3926736..3927716 1 NC_003155.4 ABC transporter periplasmic component; ABC transporter permease 3927716 bldKC1 1210674 bldKC1 Streptomyces avermitilis MA-4680 ABC transporter permease NP_824328.1 3926736 D 227882 CDS NP_824329.1 29829695 1210675 3927777..3928847 1 NC_003155.4 ABC transporter ATP-binding protein; ABC transporter ATPase 3928847 bldKD1 1210675 bldKD1 Streptomyces avermitilis MA-4680 ABC transporter ATPase NP_824329.1 3927777 D 227882 CDS NP_824330.1 29829696 1210676 3928871..3929917 1 NC_003155.4 ABC transporter ATP-binding protein 3929917 bldKE1 1210676 bldKE1 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_824330.1 3928871 D 227882 CDS NP_824331.1 29829697 1214265 complement(3930088..3930255) 1 NC_003155.4 nrps3 gene cluster; MbtH-like protein 3930255 1214265 SAV_3155 Streptomyces avermitilis MA-4680 MbtH-like protein NP_824331.1 3930088 R 227882 CDS NP_824332.1 29829698 1214266 complement(3930306..3932183) 1 NC_003155.4 nrps3 gene cluster; non-ribosomal peptide synthetase 3932183 nrps3-1 1214266 nrps3-1 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_824332.1 3930306 R 227882 CDS NP_824333.1 29829699 1214267 complement(3932261..3933553) 1 NC_003155.4 nrps3 gene cluster, PF07690: Major Facilitator Superfamily; export protein 3933553 1214267 SAV_3157 Streptomyces avermitilis MA-4680 export protein NP_824333.1 3932261 R 227882 CDS NP_824334.1 29829700 1214268 complement(3933613..3934425) 1 NC_003155.4 nrps3 gene cluster; non-ribosomal peptide synthetase 3934425 nrps3-2 1214268 nrps3-2 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_824334.1 3933613 R 227882 CDS NP_824335.1 29829701 1214269 complement(3934439..3937489) 1 NC_003155.4 nrps3 gene cluster; non-ribosomal peptide synthetase 3937489 nrps3-3 1214269 nrps3-3 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_824335.1 3934439 R 227882 CDS NP_824336.1 29829702 1214270 complement(3937627..3938730) 1 NC_003155.4 nrps3 gene cluster; aminotransferase 3938730 1214270 SAV_3160 Streptomyces avermitilis MA-4680 aminotransferase NP_824336.1 3937627 R 227882 CDS NP_824337.1 29829703 1210677 complement(3938765..3939688) 1 NC_003155.4 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 3939688 dapF 1210677 dapF Streptomyces avermitilis MA-4680 diaminopimelate epimerase NP_824337.1 3938765 R 227882 CDS NP_824338.1 29829704 1214271 complement(3939735..3940430) 1 NC_003155.4 hypothetical protein 3940430 1214271 SAV_3162 Streptomyces avermitilis MA-4680 hypothetical protein NP_824338.1 3939735 R 227882 CDS NP_824339.1 29829705 1214272 complement(3940462..3941439) 1 NC_003155.4 hypothetical protein 3941439 1214272 SAV_3163 Streptomyces avermitilis MA-4680 hypothetical protein NP_824339.1 3940462 R 227882 CDS NP_824340.1 29829706 1214273 complement(3941820..3942062) 1 NC_003155.4 hypothetical protein 3942062 1214273 SAV_3164 Streptomyces avermitilis MA-4680 hypothetical protein NP_824340.1 3941820 R 227882 CDS NP_824341.1 29829707 1214274 3942121..3943161 1 NC_003155.4 LuxR family transcriptional regulator 3943161 1214274 SAV_3165 Streptomyces avermitilis MA-4680 LuxR family transcriptional regulator NP_824341.1 3942121 D 227882 CDS NP_824342.1 29829708 1214275 complement(3943089..3944108) 1 NC_003155.4 AraC family transcription regulator 3944108 1214275 SAV_3166 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_824342.1 3943089 R 227882 CDS NP_824343.1 29829709 1214276 3944179..3944508 1 NC_003155.4 hypothetical protein 3944508 1214276 SAV_3167 Streptomyces avermitilis MA-4680 hypothetical protein NP_824343.1 3944179 D 227882 CDS NP_824344.1 29829710 1214277 complement(3944522..3945043) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 3945043 1214277 SAV_3168 Streptomyces avermitilis MA-4680 acetyltransferase NP_824344.1 3944522 R 227882 CDS NP_824345.1 29829711 1214278 complement(3945049..3945456) 1 NC_003155.4 hypothetical protein 3945456 1214278 SAV_3169 Streptomyces avermitilis MA-4680 hypothetical protein NP_824345.1 3945049 R 227882 CDS NP_824346.1 29829712 1214279 complement(3945461..3945964) 1 NC_003155.4 PF04978: Protein of unknown function (DUF664); hypothetical protein 3945964 1214279 SAV_3170 Streptomyces avermitilis MA-4680 hypothetical protein NP_824346.1 3945461 R 227882 CDS NP_824347.1 29829713 1214280 3946132..3946872 1 NC_003155.4 methyltransferase 3946872 1214280 SAV_3171 Streptomyces avermitilis MA-4680 methyltransferase NP_824347.1 3946132 D 227882 CDS NP_824348.1 29829714 1210678 complement(3946897..3948111) 1 NC_003155.4 ABC transporter ATP-binding protein 3948111 bldKE2 1210678 bldKE2 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_824348.1 3946897 R 227882 CDS NP_824349.1 29829715 1210679 complement(3948185..3949246) 1 NC_003155.4 ABC transporter ATP-binding protein; ABC transporter ATPase 3949246 bldKD2 1210679 bldKD2 Streptomyces avermitilis MA-4680 ABC transporter ATPase NP_824349.1 3948185 R 227882 CDS NP_824350.1 29829716 1210680 complement(3949256..3950236) 1 NC_003155.4 ABC transporter periplasmic component; ABC transporter permease 3950236 bldKC2 1210680 bldKC2 Streptomyces avermitilis MA-4680 ABC transporter permease NP_824350.1 3949256 R 227882 CDS NP_824351.1 29829717 1210681 complement(3950336..3952147) 1 NC_003155.4 ABC transporter periplasmic component; ABC transporter 3952147 bldKB2 1210681 bldKB2 Streptomyces avermitilis MA-4680 ABC transporter NP_824351.1 3950336 R 227882 CDS NP_824352.1 29829718 1210682 complement(3952264..3953298) 1 NC_003155.4 ABC transporter periplasmic component; ABC transporter permease 3953298 bldKA2 1210682 bldKA2 Streptomyces avermitilis MA-4680 ABC transporter permease NP_824352.1 3952264 R 227882 CDS NP_824353.1 29829719 1214281 complement(3953896..3955803) 1 NC_003155.4 GTP-binding elongation factor 3955803 typA 1214281 typA Streptomyces avermitilis MA-4680 GTP-binding elongation factor NP_824353.1 3953896 R 227882 CDS NP_824354.1 29829720 1214282 complement(3955987..3958224) 1 NC_003155.4 PF00497: Bacterial extracellular solute-binding proteins, family 3; lipoprotein 3958224 1214282 SAV_3178 Streptomyces avermitilis MA-4680 lipoprotein NP_824354.1 3955987 R 227882 CDS NP_824355.1 29829721 1214283 3958634..3958921 1 NC_003155.4 hypothetical protein 3958921 1214283 SAV_3179 Streptomyces avermitilis MA-4680 hypothetical protein NP_824355.1 3958634 D 227882 CDS NP_824356.1 29829722 1214284 3958978..3959799 1 NC_003155.4 hypothetical protein 3959799 1214284 SAV_3180 Streptomyces avermitilis MA-4680 hypothetical protein NP_824356.1 3958978 D 227882 CDS NP_824357.1 29829723 1210683 3959816..3961819 1 NC_003155.4 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 3961819 sdhA 1210683 sdhA Streptomyces avermitilis MA-4680 succinate dehydrogenase flavoprotein subunit NP_824357.1 3959816 D 227882 CDS NP_824358.1 29829724 1210684 3961816..3962592 1 NC_003155.4 catalyzes the fumarate and succinate interconversion; fumarate reductase is used under anaerobic conditions with glucose or glycerol as carbon source; fumarate reductase iron-sulfur subunit 3962592 sdhB2 1210684 sdhB2 Streptomyces avermitilis MA-4680 fumarate reductase iron-sulfur subunit NP_824358.1 3961816 D 227882 CDS NP_824359.1 29829725 1214285 complement(3962688..3963926) 1 NC_003155.4 hypothetical protein 3963926 1214285 SAV_3183 Streptomyces avermitilis MA-4680 hypothetical protein NP_824359.1 3962688 R 227882 CDS NP_824360.1 29829726 1214286 3964078..3966321 1 NC_003155.4 hypothetical protein 3966321 1214286 SAV_3184 Streptomyces avermitilis MA-4680 hypothetical protein NP_824360.1 3964078 D 227882 CDS NP_824361.1 29829727 1214287 complement(3966409..3969351) 1 NC_003155.4 PF01590: GAF domain; magnesium or manganese-dependent protein phosphatase 3969351 prpM3 1214287 prpM3 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_824361.1 3966409 R 227882 CDS NP_824362.1 29829728 1214288 complement(3969517..3969975) 1 NC_003155.4 regulatory protein 3969975 1214288 SAV_3186 Streptomyces avermitilis MA-4680 regulatory protein NP_824362.1 3969517 R 227882 CDS NP_824363.1 29829729 1214289 complement(3970140..3970532) 1 NC_003155.4 mutT-like protein 3970532 1214289 SAV_3187 Streptomyces avermitilis MA-4680 mutT-like protein NP_824363.1 3970140 R 227882 CDS NP_824364.1 29829730 1214290 complement(3970606..3970788) 1 NC_003155.4 hypothetical protein 3970788 1214290 SAV_3188 Streptomyces avermitilis MA-4680 hypothetical protein NP_824364.1 3970606 R 227882 CDS NP_824365.1 29829731 1214291 complement(3971116..3971868) 1 NC_003155.4 GntR family transcriptional regulator 3971868 1214291 SAV_3189 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_824365.1 3971116 R 227882 CDS NP_824366.1 29829732 1214292 complement(3972016..3973185) 1 NC_003155.4 hypothetical protein 3973185 1214292 SAV_3190 Streptomyces avermitilis MA-4680 hypothetical protein NP_824366.1 3972016 R 227882 CDS NP_824367.1 29829733 1210685 3973434..3974567 1 NC_003155.4 threonine synthase 3974567 thrC2 1210685 thrC2 Streptomyces avermitilis MA-4680 threonine synthase NP_824367.1 3973434 D 227882 CDS NP_824368.1 29829734 1214293 complement(3974801..3976906) 1 NC_003155.4 bifunctional protein 3976906 1214293 SAV_3192 Streptomyces avermitilis MA-4680 bifunctional protein NP_824368.1 3974801 R 227882 CDS NP_824369.1 29829735 1210686 complement(3977231..3977905) 1 NC_003155.4 PF01648: 4'-phosphopantetheinyl transferase superfamily; phosphopantetheinyl transferase 3977905 pptA3 1210686 pptA3 Streptomyces avermitilis MA-4680 phosphopantetheinyl transferase NP_824369.1 3977231 R 227882 CDS NP_824370.1 29829736 1214294 complement(3977950..3978756) 1 NC_003155.4 PF00795: Carbon-nitrogen hydrolase; hydrolase 3978756 1214294 SAV_3194 Streptomyces avermitilis MA-4680 hydrolase NP_824370.1 3977950 R 227882 CDS NP_824371.1 29829737 1214295 complement(3978837..3979130) 1 NC_003155.4 PF06063: Domain of unknown function (DUF931); hypothetical protein 3979130 1214295 SAV_3195 Streptomyces avermitilis MA-4680 hypothetical protein NP_824371.1 3978837 R 227882 CDS NP_824372.1 29829738 1214296 complement(3979154..3980047) 1 NC_003155.4 PF03591: AzlC protein; hypothetical protein 3980047 1214296 SAV_3196 Streptomyces avermitilis MA-4680 hypothetical protein NP_824372.1 3979154 R 227882 CDS NP_824373.1 29829739 1214297 complement(3980213..3985519) 1 NC_003155.4 nrps1 gene cluster; non-ribosomal peptide synthetase 3985519 nrps1-1 1214297 nrps1-1 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_824373.1 3980213 R 227882 CDS NP_824374.1 29829740 1214298 complement(3985548..3989339) 1 NC_003155.4 nrps1 gene cluster; non-ribosomal peptide synthetase 3989339 nrps1-2 1214298 nrps1-2 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_824374.1 3985548 R 227882 CDS NP_824375.1 29829741 1214299 complement(3989374..3992310) 1 NC_003155.4 nrps1 gene cluster; non-ribosomal peptide synthetase 3992310 nrps1-3 1214299 nrps1-3 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_824375.1 3989374 R 227882 CDS NP_824376.1 29829742 1214300 complement(3992464..3993294) 1 NC_003155.4 nrps1 gene cluster, PF00106: short chain dehydrogenase; dehydrogenase 3993294 1214300 SAV_3200 Streptomyces avermitilis MA-4680 dehydrogenase NP_824376.1 3992464 R 227882 CDS NP_824377.1 29829743 1214301 complement(3993291..3994004) 1 NC_003155.4 nrps1 gene cluster; thioesterase 3994004 1214301 SAV_3201 Streptomyces avermitilis MA-4680 thioesterase NP_824377.1 3993291 R 227882 CDS NP_824378.1 29829744 1214302 complement(3994107..3994940) 1 NC_003155.4 nrps1 gene cluster; thioesterase 3994940 1214302 SAV_3202 Streptomyces avermitilis MA-4680 thioesterase NP_824378.1 3994107 R 227882 CDS NP_824379.1 29829745 1214303 3995124..3996191 1 NC_003155.4 nrps1 gene cluster, LuxR-family; regulatory protein 3996191 1214303 SAV_3203 Streptomyces avermitilis MA-4680 regulatory protein NP_824379.1 3995124 D 227882 CDS NP_824380.1 29829746 1214304 complement(3996878..3997273) 1 NC_003155.4 hypothetical protein 3997273 1214304 SAV_3204 Streptomyces avermitilis MA-4680 hypothetical protein NP_824380.1 3996878 R 227882 CDS NP_824381.1 29829747 1214305 complement(3997841..3998095) 1 NC_003155.4 homology to AviX3 Streptomyces viridochromogenes, PF06769: Protein of unknown function (DUF1224); hypothetical protein 3998095 1214305 SAV_3205 Streptomyces avermitilis MA-4680 hypothetical protein NP_824381.1 3997841 R 227882 CDS NP_824382.1 29829748 1214306 complement(3998092..3998373) 1 NC_003155.4 homology to AviX2 Streptomyces viridochromogenes, PF02604: Phd_YefM; hypothetical protein 3998373 1214306 SAV_3206 Streptomyces avermitilis MA-4680 hypothetical protein NP_824382.1 3998092 R 227882 CDS NP_824383.1 29829749 1214307 complement(3998574..3999662) 1 NC_003155.4 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 3999662 1214307 SAV_3207 Streptomyces avermitilis MA-4680 GTP-dependent nucleic acid-binding protein EngD NP_824383.1 3998574 R 227882 CDS NP_824384.1 29829750 1214308 3999878..4000591 1 NC_003155.4 hypothetical protein 4000591 1214308 SAV_3208 Streptomyces avermitilis MA-4680 hypothetical protein NP_824384.1 3999878 D 227882 CDS NP_824385.1 29829751 1210687 complement(4000786..4001532) 1 NC_003155.4 PF00480: ROK family; polyphosphate glucokinase 4001532 ppgK 1210687 ppgK Streptomyces avermitilis MA-4680 polyphosphate glucokinase NP_824385.1 4000786 R 227882 CDS NP_824386.1 29829752 1210688 complement(4001562..4002578) 1 NC_003155.4 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 4002578 ispH 1210688 ispH Streptomyces avermitilis MA-4680 4-hydroxy-3-methylbut-2-enyl diphosphate reductase NP_824386.1 4001562 R 227882 CDS NP_824387.1 29829753 1210689 4002836..4004044 1 NC_003155.4 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 4004044 xseA 1210689 xseA Streptomyces avermitilis MA-4680 exodeoxyribonuclease VII large subunit NP_824387.1 4002836 D 227882 CDS NP_824388.1 29829754 1210690 4004054..4004296 1 NC_003155.4 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 4004296 xseB 1210690 xseB Streptomyces avermitilis MA-4680 exodeoxyribonuclease VII small subunit NP_824388.1 4004054 D 227882 CDS NP_824389.1 29829755 1214309 4004666..4005256 1 NC_003155.4 PF00881: Nitroreductase family; hypothetical protein 4005256 1214309 SAV_3213 Streptomyces avermitilis MA-4680 hypothetical protein NP_824389.1 4004666 D 227882 CDS NP_824390.1 29829756 1214310 complement(4005458..4005979) 1 NC_003155.4 protein 4005979 1214310 SAV_3214 Streptomyces avermitilis MA-4680 protein NP_824390.1 4005458 R 227882 CDS NP_824391.1 29829757 1214311 4006107..4007141 1 NC_003155.4 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 4007141 glpX 1214311 glpX Streptomyces avermitilis MA-4680 fructose 1,6-bisphosphatase II NP_824391.1 4006107 D 227882 CDS NP_824392.1 29829758 1210691 complement(4007271..4007642) 1 NC_003155.4 PF02467: Transcription factor WhiB; WhiB-family transcriptional regulator 4007642 wblI 1210691 wblI Streptomyces avermitilis MA-4680 WhiB-family transcriptional regulator NP_824392.1 4007271 R 227882 CDS NP_824393.1 29829759 1214312 complement(4007817..4008521) 1 NC_003155.4 hypothetical protein 4008521 1214312 SAV_3217 Streptomyces avermitilis MA-4680 hypothetical protein NP_824393.1 4007817 R 227882 CDS NP_824394.1 29829760 1210692 4008701..4010377 1 NC_003155.4 fumarate hydratase class I 4010377 fumB 1210692 fumB Streptomyces avermitilis MA-4680 fumarate hydratase class I NP_824394.1 4008701 D 227882 CDS NP_824395.1 29829761 1214313 4010565..4011002 1 NC_003155.4 hypothetical protein 4011002 1214313 SAV_3219 Streptomyces avermitilis MA-4680 hypothetical protein NP_824395.1 4010565 D 227882 CDS NP_824396.1 29829762 1214314 4011015..4014206 1 NC_003155.4 PF05729: NACHT domain; hypothetical protein 4014206 1214314 SAV_3220 Streptomyces avermitilis MA-4680 hypothetical protein NP_824396.1 4011015 D 227882 CDS NP_824397.1 29829763 1210693 4014275..4015678 1 NC_003155.4 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 4015678 fumC 1210693 fumC Streptomyces avermitilis MA-4680 fumarate hydratase NP_824397.1 4014275 D 227882 CDS NP_824398.1 29829764 1214315 4015793..4016485 1 NC_003155.4 PF04167: Protein of unknown function (DUF402); hypothetical protein 4016485 1214315 SAV_3222 Streptomyces avermitilis MA-4680 hypothetical protein NP_824398.1 4015793 D 227882 CDS NP_824399.1 29829765 1214316 4016768..4018918 1 NC_003155.4 PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; magnesium or manganese-dependent protein phosphatase 4018918 prpE2 1214316 prpE2 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_824399.1 4016768 D 227882 CDS NP_824400.1 29829766 1210694 4019075..4020538 1 NC_003155.4 catalase 4020538 katA2 1210694 katA2 Streptomyces avermitilis MA-4680 catalase NP_824400.1 4019075 D 227882 CDS NP_824401.1 29829767 1210695 complement(4020616..4022949) 1 NC_003155.4 PF00912: Transglycosylase; penicillin-binding protein 4022949 pbp2 1210695 pbp2 Streptomyces avermitilis MA-4680 penicillin-binding protein NP_824401.1 4020616 R 227882 CDS NP_824402.1 29829768 1214317 4023232..4024179 1 NC_003155.4 PF01145: SPFH domain / Band 7 family; integral membrane protein 4024179 1214317 SAV_3226 Streptomyces avermitilis MA-4680 integral membrane protein NP_824402.1 4023232 D 227882 CDS NP_824403.1 29829769 1214318 4024176..4024439 1 NC_003155.4 hypothetical protein 4024439 1214318 SAV_3227 Streptomyces avermitilis MA-4680 hypothetical protein NP_824403.1 4024176 D 227882 CDS NP_824404.1 29829770 1214319 4024588..4025115 1 NC_003155.4 PadR-family transcriptional regulator 4025115 1214319 SAV_3228 Streptomyces avermitilis MA-4680 PadR-family transcriptional regulator NP_824404.1 4024588 D 227882 CDS NP_824405.1 29829771 1214320 4025112..4025798 1 NC_003155.4 ABC transporter ATP-binding protein 4025798 1214320 SAV_3229 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_824405.1 4025112 D 227882 CDS NP_824406.1 29829772 1214321 4025795..4028131 1 NC_003155.4 PF02687: Predicted permease; integral membrane protein 4028131 1214321 SAV_3230 Streptomyces avermitilis MA-4680 integral membrane protein NP_824406.1 4025795 D 227882 CDS NP_824407.1 29829773 1210696 complement(4028192..4029202) 1 NC_003155.4 hydrogen peroxide sensing regulator 4029202 oxyR 1210696 oxyR Streptomyces avermitilis MA-4680 hydrogen peroxide sensing regulator NP_824407.1 4028192 R 227882 CDS NP_824408.1 29829774 1210697 4029374..4029928 1 NC_003155.4 alkyl hydroperoxide reductase 4029928 ahpC 1210697 ahpC Streptomyces avermitilis MA-4680 alkyl hydroperoxide reductase NP_824408.1 4029374 D 227882 CDS NP_824409.1 29829775 1210698 4029935..4030468 1 NC_003155.4 alkylhydroperoxidase 4030468 ahpD 1210698 ahpD Streptomyces avermitilis MA-4680 alkylhydroperoxidase NP_824409.1 4029935 D 227882 CDS NP_824410.1 29829776 1214322 complement(4030554..4031876) 1 NC_003155.4 PF01594: Domain of unknown function DUF20; integral membrane protein 4031876 1214322 SAV_3234 Streptomyces avermitilis MA-4680 integral membrane protein NP_824410.1 4030554 R 227882 CDS NP_824411.1 29829777 1214323 complement(4032029..4032742) 1 NC_003155.4 PF06737: Transglycosylase-like domain; hypothetical protein 4032742 1214323 SAV_3235 Streptomyces avermitilis MA-4680 hypothetical protein NP_824411.1 4032029 R 227882 CDS NP_824412.1 29829778 1214324 complement(4033150..4034475) 1 NC_003155.4 ATP-binding protein 4034475 1214324 SAV_3236 Streptomyces avermitilis MA-4680 ATP-binding protein NP_824412.1 4033150 R 227882 CDS NP_824413.1 29829779 1210699 complement(4034777..4035550) 1 NC_003155.4 catalyzes the formation of UDP pyrophosphate from isopentenyl pyrophosphate; UDP pyrophosphate synthase 4035550 uppS1 1210699 uppS1 Streptomyces avermitilis MA-4680 UDP pyrophosphate synthase NP_824413.1 4034777 R 227882 CDS NP_824414.1 29829780 1214325 4036211..4036801 1 NC_003155.4 PF02643: Uncharacterized ACR, COG1430; hypothetical protein 4036801 1214325 SAV_3238 Streptomyces avermitilis MA-4680 hypothetical protein NP_824414.1 4036211 D 227882 CDS NP_824415.1 29829781 1214326 4037259..4038419 1 NC_003155.4 hypothetical protein 4038419 1214326 SAV_3239 Streptomyces avermitilis MA-4680 hypothetical protein NP_824415.1 4037259 D 227882 CDS NP_824416.1 29829782 1214327 complement(4038477..4039337) 1 NC_003155.4 hypothetical protein 4039337 1214327 SAV_3240 Streptomyces avermitilis MA-4680 hypothetical protein NP_824416.1 4038477 R 227882 CDS NP_824417.1 29829783 1214328 4039440..4039925 1 NC_003155.4 PF04978: Protein of unknown function (DUF664); hypothetical protein 4039925 1214328 SAV_3241 Streptomyces avermitilis MA-4680 hypothetical protein NP_824417.1 4039440 D 227882 CDS NP_824418.1 29829784 1214329 complement(4039968..4040474) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 4040474 1214329 SAV_3242 Streptomyces avermitilis MA-4680 acetyltransferase NP_824418.1 4039968 R 227882 CDS NP_824419.1 29829785 1214330 complement(4040505..4041377) 1 NC_003155.4 FMNH2-utilizing oxygenase 4041377 1214330 SAV_3243 Streptomyces avermitilis MA-4680 FMNH2-utilizing oxygenase NP_824419.1 4040505 R 227882 CDS NP_824420.1 29829786 1214331 complement(4041419..4042066) 1 NC_003155.4 PF01872: RibD C-terminal domain; hypothetical protein 4042066 1214331 SAV_3244 Streptomyces avermitilis MA-4680 hypothetical protein NP_824420.1 4041419 R 227882 CDS NP_824421.1 29829787 1214332 complement(4042190..4042870) 1 NC_003155.4 PF00691: OmpA family; protein 4042870 1214332 SAV_3245 Streptomyces avermitilis MA-4680 protein NP_824421.1 4042190 R 227882 CDS NP_824422.1 29829788 1214333 complement(4042874..4043467) 1 NC_003155.4 hypothetical protein 4043467 1214333 SAV_3246 Streptomyces avermitilis MA-4680 hypothetical protein NP_824422.1 4042874 R 227882 CDS NP_824423.1 29829789 1214334 complement(4043483..4044037) 1 NC_003155.4 hypothetical protein 4044037 1214334 SAV_3247 Streptomyces avermitilis MA-4680 hypothetical protein NP_824423.1 4043483 R 227882 CDS NP_824424.1 29829790 1214335 complement(4044097..4044312) 1 NC_003155.4 hypothetical protein 4044312 1214335 SAV_3248 Streptomyces avermitilis MA-4680 hypothetical protein NP_824424.1 4044097 R 227882 CDS NP_824425.1 29829791 1214336 complement(4044439..4045170) 1 NC_003155.4 two-component system response regulator 4045170 1214336 SAV_3249 Streptomyces avermitilis MA-4680 two-component system response regulator NP_824425.1 4044439 R 227882 CDS NP_824426.1 29829792 1214337 complement(4045163..4046581) 1 NC_003155.4 two-component system sensor kinase 4046581 1214337 SAV_3250 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_824426.1 4045163 R 227882 CDS NP_824427.1 29829793 1214338 complement(4046593..4047498) 1 NC_003155.4 PF00482: Bacterial type II secretion system protein F domain; hypothetical protein 4047498 1214338 SAV_3251 Streptomyces avermitilis MA-4680 hypothetical protein NP_824427.1 4046593 R 227882 CDS NP_824428.1 29829794 1214339 complement(4047510..4048451) 1 NC_003155.4 PF00482: Bacterial type II secretion system protein F domain; hypothetical protein 4048451 1214339 SAV_3252 Streptomyces avermitilis MA-4680 hypothetical protein NP_824428.1 4047510 R 227882 CDS NP_824429.1 29829795 1214340 complement(4048501..4049841) 1 NC_003155.4 secretory protein 4049841 1214340 SAV_3253 Streptomyces avermitilis MA-4680 secretory protein NP_824429.1 4048501 R 227882 CDS NP_824430.1 29829796 1214341 complement(4049931..4050083) 1 NC_003155.4 hypothetical protein 4050083 1214341 SAV_3254 Streptomyces avermitilis MA-4680 hypothetical protein NP_824430.1 4049931 R 227882 CDS NP_824431.1 29829797 1210700 complement(4050333..4051940) 1 NC_003155.4 septum site-determining protein 4051940 minD1 1210700 minD1 Streptomyces avermitilis MA-4680 septum site-determining protein NP_824431.1 4050333 R 227882 CDS NP_824432.1 29829798 1214342 complement(4052009..4052638) 1 NC_003155.4 PF06981: Flp pilus assembly protein CpaB; hypothetical protein 4052638 1214342 SAV_3256 Streptomyces avermitilis MA-4680 hypothetical protein NP_824432.1 4052009 R 227882 CDS NP_824433.1 29829799 1214343 complement(4052801..4053688) 1 NC_003155.4 hypothetical protein 4053688 1214343 SAV_3257 Streptomyces avermitilis MA-4680 hypothetical protein NP_824433.1 4052801 R 227882 CDS NP_824434.1 29829800 1210701 4054020..4055759 1 NC_003155.4 chitinase A 4055759 chiA1 1210701 chiA1 Streptomyces avermitilis MA-4680 chitinase A NP_824434.1 4054020 D 227882 CDS NP_824435.1 29829801 1214344 4056529..4056882 1 NC_003155.4 hypothetical protein 4056882 1214344 SAV_3259 Streptomyces avermitilis MA-4680 hypothetical protein NP_824435.1 4056529 D 227882 CDS NP_824436.1 29829802 1214345 4056905..4057366 1 NC_003155.4 hypothetical protein 4057366 1214345 SAV_3260 Streptomyces avermitilis MA-4680 hypothetical protein NP_824436.1 4056905 D 227882 CDS NP_824437.1 29829803 1214346 4057820..4059073 1 NC_003155.4 hypothetical protein 4059073 1214346 SAV_3261 Streptomyces avermitilis MA-4680 hypothetical protein NP_824437.1 4057820 D 227882 CDS NP_824438.1 29829804 1214347 complement(4059066..4059590) 1 NC_003155.4 regulatory protein 4059590 1214347 SAV_3262 Streptomyces avermitilis MA-4680 regulatory protein NP_824438.1 4059066 R 227882 CDS NP_824439.1 29829805 1214348 4059832..4060683 1 NC_003155.4 DNA-binding protein 4060683 1214348 SAV_3263 Streptomyces avermitilis MA-4680 DNA-binding protein NP_824439.1 4059832 D 227882 CDS NP_824440.1 29829806 1214349 4060692..4060886 1 NC_003155.4 hypothetical protein 4060886 1214349 SAV_3264 Streptomyces avermitilis MA-4680 hypothetical protein NP_824440.1 4060692 D 227882 CDS NP_824441.1 29829807 1214350 complement(4060888..4061418) 1 NC_003155.4 hypothetical protein 4061418 1214350 SAV_3265 Streptomyces avermitilis MA-4680 hypothetical protein NP_824441.1 4060888 R 227882 CDS NP_824442.1 29829808 1214351 4061623..4062975 1 NC_003155.4 PF00246: Zinc carboxypeptidase; carboxypeptidase 4062975 1214351 SAV_3266 Streptomyces avermitilis MA-4680 carboxypeptidase NP_824442.1 4061623 D 227882 CDS NP_824443.1 29829809 1214352 complement(4063001..4063606) 1 NC_003155.4 hypothetical protein 4063606 1214352 SAV_3267 Streptomyces avermitilis MA-4680 hypothetical protein NP_824443.1 4063001 R 227882 CDS NP_824444.1 29829810 1214353 complement(4063733..4065298) 1 NC_003155.4 PF00004: ATPase family associated with various cellular activities (AAA); ATPase 4065298 1214353 SAV_3268 Streptomyces avermitilis MA-4680 ATPase NP_824444.1 4063733 R 227882 CDS NP_824445.1 29829811 1214354 complement(4065495..4066115) 1 NC_003155.4 hypothetical protein 4066115 1214354 SAV_3269 Streptomyces avermitilis MA-4680 hypothetical protein NP_824445.1 4065495 R 227882 CDS NP_824446.1 29829812 1214355 complement(4066470..4068242) 1 NC_003155.4 PF04956: Conjugal transfer protein TrbC; hypothetical protein 4068242 1214355 SAV_3270 Streptomyces avermitilis MA-4680 hypothetical protein NP_824446.1 4066470 R 227882 CDS NP_824447.1 29829813 1214356 complement(4068315..4068863) 1 NC_003155.4 hypothetical protein 4068863 1214356 SAV_3271 Streptomyces avermitilis MA-4680 hypothetical protein NP_824447.1 4068315 R 227882 CDS NP_824448.1 29829814 1214357 4069022..4071052 1 NC_003155.4 PF00656: Caspase domain; hypothetical protein 4071052 1214357 SAV_3272 Streptomyces avermitilis MA-4680 hypothetical protein NP_824448.1 4069022 D 227882 CDS NP_824449.1 29829815 1214358 complement(4071033..4075478) 1 NC_003155.4 hypothetical protein 4075478 1214358 SAV_3273 Streptomyces avermitilis MA-4680 hypothetical protein NP_824449.1 4071033 R 227882 CDS NP_824450.1 29829816 1214359 complement(4075537..4076190) 1 NC_003155.4 hypothetical protein 4076190 1214359 SAV_3274 Streptomyces avermitilis MA-4680 hypothetical protein NP_824450.1 4075537 R 227882 CDS NP_824451.1 29829817 1214360 complement(4076193..4076861) 1 NC_003155.4 hypothetical protein 4076861 1214360 SAV_3275 Streptomyces avermitilis MA-4680 hypothetical protein NP_824451.1 4076193 R 227882 CDS NP_824452.1 29829818 1214361 complement(4076881..4078074) 1 NC_003155.4 hypothetical protein 4078074 1214361 SAV_3276 Streptomyces avermitilis MA-4680 hypothetical protein NP_824452.1 4076881 R 227882 CDS NP_824453.1 29829819 1214362 complement(4078192..4079679) 1 NC_003155.4 PF02447: GntP family permease; low-affinity gluconate transporter 4079679 1214362 SAV_3277 Streptomyces avermitilis MA-4680 low-affinity gluconate transporter NP_824453.1 4078192 R 227882 CDS NP_824454.1 29829820 1214363 complement(4079800..4080219) 1 NC_003155.4 PF01042: Endoribonuclease L-PSP; hypothetical protein 4080219 1214363 SAV_3278 Streptomyces avermitilis MA-4680 hypothetical protein NP_824454.1 4079800 R 227882 CDS NP_824455.1 29829821 1214364 complement(4080229..4081023) 1 NC_003155.4 IclR family transcriptional regulator 4081023 1214364 SAV_3279 Streptomyces avermitilis MA-4680 IclR family transcriptional regulator NP_824455.1 4080229 R 227882 CDS NP_824456.1 29829822 1210702 complement(4081020..4082105) 1 NC_003155.4 2-oxo-3-deoxygluconate kinase 4082105 kdgK 1210702 kdgK Streptomyces avermitilis MA-4680 2-oxo-3-deoxygluconate kinase NP_824456.1 4081020 R 227882 CDS NP_824457.1 29829823 1214365 4082240..4083511 1 NC_003155.4 PF01168: Alanine racemase, N-terminal domain; D-amino acid deaminase 4083511 1214365 SAV_3281 Streptomyces avermitilis MA-4680 D-amino acid deaminase NP_824457.1 4082240 D 227882 CDS NP_824458.1 29829824 1214366 4083587..4085179 1 NC_003155.4 PF01979: Amidohydrolase family; D-aminoacylase 4085179 1214366 SAV_3282 Streptomyces avermitilis MA-4680 D-aminoacylase NP_824458.1 4083587 D 227882 CDS NP_824459.1 29829825 1214367 complement(4085198..4085839) 1 NC_003155.4 hypothetical protein 4085839 1214367 SAV_3283 Streptomyces avermitilis MA-4680 hypothetical protein NP_824459.1 4085198 R 227882 CDS NP_824460.1 29829826 1214368 complement(4086337..4087140) 1 NC_003155.4 hypothetical protein 4087140 1214368 SAV_3284 Streptomyces avermitilis MA-4680 hypothetical protein NP_824460.1 4086337 R 227882 CDS NP_824461.1 29829827 1214369 4087192..4088403 1 NC_003155.4 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 4088403 aspB3 1214369 aspB3 Streptomyces avermitilis MA-4680 aminotransferase AlaT NP_824461.1 4087192 D 227882 CDS NP_824462.1 29829828 1214370 4088541..4088960 1 NC_003155.4 hypothetical protein 4088960 1214370 SAV_3286 Streptomyces avermitilis MA-4680 hypothetical protein NP_824462.1 4088541 D 227882 CDS NP_824463.1 29829829 1210703 complement(4089495..4091318) 1 NC_003155.4 catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using GTP; phosphoenolpyruvate carboxykinase 4091318 pck 1210703 pck Streptomyces avermitilis MA-4680 phosphoenolpyruvate carboxykinase NP_824463.1 4089495 R 227882 CDS NP_824464.1 29829830 1214371 4091675..4092388 1 NC_003155.4 PF03006: Uncharacterised protein family (Hly-III / UPF0073); hypothetical protein 4092388 1214371 SAV_3288 Streptomyces avermitilis MA-4680 hypothetical protein NP_824464.1 4091675 D 227882 CDS NP_824465.1 29829831 1214372 4092550..4094124 1 NC_003155.4 similar to monensin resistance protein MonT, PF07690: Major Facilitator Superfamily; integral membrane efflux protein 4094124 1214372 SAV_3289 Streptomyces avermitilis MA-4680 integral membrane efflux protein NP_824465.1 4092550 D 227882 CDS NP_824466.1 29829832 1214373 4094130..4094792 1 NC_003155.4 TetR family transcriptional regulator 4094792 1214373 SAV_3290 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_824466.1 4094130 D 227882 CDS NP_824467.1 29829833 1214374 4094797..4095522 1 NC_003155.4 PF01927: Protein of unknown function DUF82; hypothetical protein 4095522 1214374 SAV_3291 Streptomyces avermitilis MA-4680 hypothetical protein NP_824467.1 4094797 D 227882 CDS NP_824468.1 29829834 1214375 complement(4095519..4097792) 1 NC_003155.4 PF07250: Glyoxal oxidase N-terminus; hypothetical protein 4097792 1214375 SAV_3292 Streptomyces avermitilis MA-4680 hypothetical protein NP_824468.1 4095519 R 227882 CDS NP_824469.1 29829835 1210704 complement(4097945..4099147) 1 NC_003155.4 PF00535: Glycosyl transferase; dolichol-phosphate mannosyltransferase 4099147 dpm 1210704 dpm Streptomyces avermitilis MA-4680 dolichol-phosphate mannosyltransferase NP_824469.1 4097945 R 227882 CDS NP_824470.1 29829836 1214376 complement(4099144..4100784) 1 NC_003155.4 PF02366: Dolichyl-phosphate-mannose-protein mannosyltransferase; hypothetical protein 4100784 1214376 SAV_3294 Streptomyces avermitilis MA-4680 hypothetical protein NP_824470.1 4099144 R 227882 CDS NP_824471.1 29829837 1214377 complement(4100781..4102091) 1 NC_003155.4 PF00535: Glycosyl transferase; glycosyl transferase 4102091 1214377 SAV_3295 Streptomyces avermitilis MA-4680 glycosyl transferase NP_824471.1 4100781 R 227882 CDS NP_824472.1 29829838 1214378 complement(4102247..4104274) 1 NC_003155.4 PF03190: Protein of unknown function, DUF255; hypothetical protein 4104274 1214378 SAV_3296 Streptomyces avermitilis MA-4680 hypothetical protein NP_824472.1 4102247 R 227882 CDS NP_824473.1 29829839 1214379 4104456..4107692 1 NC_003155.4 regulatory protein 4107692 1214379 SAV_3297 Streptomyces avermitilis MA-4680 regulatory protein NP_824473.1 4104456 D 227882 CDS NP_824474.1 29829840 1214380 complement(4107799..4108113) 1 NC_003155.4 hypothetical protein 4108113 1214380 SAV_3298 Streptomyces avermitilis MA-4680 hypothetical protein NP_824474.1 4107799 R 227882 CDS NP_824475.1 29829841 1214381 complement(4108126..4108998) 1 NC_003155.4 PF02585: Uncharacterised LmbE-like protein, COG2120; hypothetical protein 4108998 1214381 SAV_3299 Streptomyces avermitilis MA-4680 hypothetical protein NP_824475.1 4108126 R 227882 CDS NP_824476.1 29829842 1214382 4109154..4109552 1 NC_003155.4 hypothetical protein 4109552 1214382 SAV_3300 Streptomyces avermitilis MA-4680 hypothetical protein NP_824476.1 4109154 D 227882 CDS NP_824477.1 29829843 1210705 4109721..4110218 1 NC_003155.4 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 4110218 greA 1210705 greA Streptomyces avermitilis MA-4680 transcription elongation factor GreA NP_824477.1 4109721 D 227882 CDS NP_824478.1 29829844 1210706 complement(4110484..4111713) 1 NC_003155.4 catalyzes the formation of 2-oxobutanoate from L-threonine; threonine dehydratase 4111713 ilvA 1210706 ilvA Streptomyces avermitilis MA-4680 threonine dehydratase NP_824478.1 4110484 R 227882 CDS NP_824479.1 29829845 1214383 4111884..4112384 1 NC_003155.4 MarR family transcriptional regulator 4112384 1214383 SAV_3303 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_824479.1 4111884 D 227882 CDS NP_824480.1 29829846 1214384 4112753..4113253 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 4113253 sig59 1214384 sig59 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_824480.1 4112753 D 227882 CDS NP_824481.1 29829847 1210707 complement(4113526..4114680) 1 NC_003155.4 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 4114680 metB 1210707 metB Streptomyces avermitilis MA-4680 cystathionine gamma-synthase NP_824481.1 4113526 R 227882 CDS NP_824482.1 29829848 1214385 4114899..4116017 1 NC_003155.4 hypothetical protein 4116017 1214385 SAV_3306 Streptomyces avermitilis MA-4680 hypothetical protein NP_824482.1 4114899 D 227882 CDS NP_824483.1 29829849 1214386 complement(4116264..4116776) 1 NC_003155.4 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 4116776 1214386 SAV_3307 Streptomyces avermitilis MA-4680 methionine sulfoxide reductase A NP_824483.1 4116264 R 227882 CDS NP_824484.1 29829850 1214387 4117077..4117670 1 NC_003155.4 hypothetical protein 4117670 1214387 SAV_3308 Streptomyces avermitilis MA-4680 hypothetical protein NP_824484.1 4117077 D 227882 CDS NP_824485.1 29829851 1214388 complement(4117931..4119991) 1 NC_003155.4 Mrr restriction system protein 4119991 savR 1214388 savR Streptomyces avermitilis MA-4680 Mrr restriction system protein NP_824485.1 4117931 R 227882 CDS NP_824486.1 29829852 1214389 4121085..4121843 1 NC_003155.4 hypothetical protein 4121843 1214389 SAV_3310 Streptomyces avermitilis MA-4680 hypothetical protein NP_824486.1 4121085 D 227882 CDS NP_824487.1 29829853 1214390 complement(4122010..4123197) 1 NC_003155.4 hypothetical protein 4123197 1214390 SAV_3311 Streptomyces avermitilis MA-4680 hypothetical protein NP_824487.1 4122010 R 227882 CDS NP_824488.1 29829854 1214391 4123347..4124225 1 NC_003155.4 PF03575: Peptidase family S51; hypothetical protein 4124225 1214391 SAV_3312 Streptomyces avermitilis MA-4680 hypothetical protein NP_824488.1 4123347 D 227882 CDS NP_824489.1 29829855 1214392 4124262..4125098 1 NC_003155.4 PF01032: FecCD transport family; iron-siderophore uptake system transmembrane component 4125098 1214392 SAV_3313 Streptomyces avermitilis MA-4680 iron-siderophore uptake system transmembrane component NP_824489.1 4124262 D 227882 CDS NP_824490.1 29829856 1210708 complement(4125234..4126277) 1 NC_003155.4 NADP-dependent alcohol dehydrogenase 4126277 adhA4 1210708 adhA4 Streptomyces avermitilis MA-4680 NADP-dependent alcohol dehydrogenase NP_824490.1 4125234 R 227882 CDS NP_824491.1 29829857 1214393 4126449..4127360 1 NC_003155.4 DNA-binding protein 4127360 1214393 SAV_3315 Streptomyces avermitilis MA-4680 DNA-binding protein NP_824491.1 4126449 D 227882 CDS NP_824492.1 29829858 1214394 complement(4127452..4128234) 1 NC_003155.4 PF01152: Bacterial-like globin; hypothetical protein 4128234 1214394 SAV_3316 Streptomyces avermitilis MA-4680 hypothetical protein NP_824492.1 4127452 R 227882 CDS NP_824493.1 29829859 1214395 complement(4128332..4128601) 1 NC_003155.4 hypothetical protein 4128601 1214395 SAV_3317 Streptomyces avermitilis MA-4680 hypothetical protein NP_824493.1 4128332 R 227882 CDS NP_824494.1 29829860 1210709 complement(4129027..4129605) 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 4129605 sig24 1210709 sig24 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_824494.1 4129027 R 227882 CDS NP_824495.1 29829861 1214396 complement(4129829..4133248) 1 NC_003155.4 PF00082: Subtilase family; subtilisin-like protease 4133248 1214396 SAV_3319 Streptomyces avermitilis MA-4680 subtilisin-like protease NP_824495.1 4129829 R 227882 CDS NP_824496.1 29829862 1214397 complement(4133353..4134036) 1 NC_003155.4 ABC transporter ATP-binding protein 4134036 1214397 SAV_3320 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_824496.1 4133353 R 227882 CDS NP_824497.1 29829863 1214398 complement(4134070..4135542) 1 NC_003155.4 PF02687: Predicted permease; integral membrane protein 4135542 1214398 SAV_3321 Streptomyces avermitilis MA-4680 integral membrane protein NP_824497.1 4134070 R 227882 CDS NP_824498.1 29829864 1214399 complement(4135745..4136995) 1 NC_003155.4 PF03734: ErfK/YbiS/YcfS/YnhG; lipoprotein 4136995 1214399 SAV_3322 Streptomyces avermitilis MA-4680 lipoprotein NP_824498.1 4135745 R 227882 CDS NP_824499.1 29829865 1214400 complement(4137239..4137532) 1 NC_003155.4 hypothetical protein 4137532 1214400 SAV_3323 Streptomyces avermitilis MA-4680 hypothetical protein NP_824499.1 4137239 R 227882 CDS NP_824500.1 29829866 1214401 4137694..4138038 1 NC_003155.4 hypothetical protein 4138038 1214401 SAV_3324 Streptomyces avermitilis MA-4680 hypothetical protein NP_824500.1 4137694 D 227882 CDS NP_824501.1 29829867 1210710 complement(4138180..4139724) 1 NC_003155.4 catalyzes the degradation of histidine to urocanate and ammmonia; histidine ammonia-lyase 4139724 hutH 1210710 hutH Streptomyces avermitilis MA-4680 histidine ammonia-lyase NP_824501.1 4138180 R 227882 CDS NP_824502.1 29829868 1214402 complement(4139856..4140947) 1 NC_003155.4 PF00990: GGDEF domain; protein 4140947 1214402 SAV_3326 Streptomyces avermitilis MA-4680 protein NP_824502.1 4139856 R 227882 CDS NP_824503.1 29829869 1210711 complement(4141081..4141893) 1 NC_003155.4 enoyl-CoA hydratase 4141893 echA9 1210711 echA9 Streptomyces avermitilis MA-4680 enoyl-CoA hydratase NP_824503.1 4141081 R 227882 CDS NP_824504.1 29829870 1214403 4142438..4142968 1 NC_003155.4 hypothetical protein 4142968 1214403 SAV_3328 Streptomyces avermitilis MA-4680 hypothetical protein NP_824504.1 4142438 D 227882 CDS NP_824505.1 29829871 1210712 complement(4143008..4144225) 1 NC_003155.4 PF00211: Adenylate and Guanylate cyclase catalytic domain; adenylate cyclase 4144225 cyaA 1210712 cyaA Streptomyces avermitilis MA-4680 adenylate cyclase NP_824505.1 4143008 R 227882 CDS NP_824506.1 29829872 1210713 complement(4144421..4145296) 1 NC_003155.4 biotin apo-protein ligase 4145296 birA 1210713 birA Streptomyces avermitilis MA-4680 biotin apo-protein ligase NP_824506.1 4144421 R 227882 CDS NP_824507.1 29829873 1210714 4145450..4147048 1 NC_003155.4 propionyl-CoA carboxylase, beta subunit 4147048 pccB 1210714 pccB Streptomyces avermitilis MA-4680 propionyl-CoA carboxylase, beta subunit NP_824507.1 4145450 D 227882 CDS NP_824508.1 29829874 1214404 4147065..4147274 1 NC_003155.4 hypothetical protein 4147274 1214404 SAV_3332 Streptomyces avermitilis MA-4680 hypothetical protein NP_824508.1 4147065 D 227882 CDS NP_824509.1 29829875 1214405 complement(4147295..4148542) 1 NC_003155.4 PF00657: GDSL-like Lipase/Acylhydrolase; protein 4148542 1214405 SAV_3333 Streptomyces avermitilis MA-4680 protein NP_824509.1 4147295 R 227882 CDS NP_824510.1 29829876 1214406 4148634..4148780 1 NC_003155.4 hypothetical protein 4148780 1214406 SAV_3334 Streptomyces avermitilis MA-4680 hypothetical protein NP_824510.1 4148634 D 227882 CDS NP_824511.1 29829877 1214407 4148785..4149405 1 NC_003155.4 PF02545: Maf-like protein; septum formation protein 4149405 1214407 SAV_3335 Streptomyces avermitilis MA-4680 septum formation protein NP_824511.1 4148785 D 227882 CDS NP_824512.1 29829878 1214408 complement(4149406..4149930) 1 NC_003155.4 integral membrane protein 4149930 1214408 SAV_3336 Streptomyces avermitilis MA-4680 integral membrane protein NP_824512.1 4149406 R 227882 CDS NP_824513.1 29829879 1210715 4150323..4152095 1 NC_003155.4 biotin carboxylase and biotin carboxyl carrier protein; acyl-CoA carboxylase alpha subunit 4152095 accA3 1210715 accA3 Streptomyces avermitilis MA-4680 acyl-CoA carboxylase alpha subunit NP_824513.1 4150323 D 227882 CDS NP_824514.1 29829880 1214409 complement(4152374..4153447) 1 NC_003155.4 PF00196: Bacterial regulatory proteins, luxR family; hypothetical protein 4153447 1214409 SAV_3338 Streptomyces avermitilis MA-4680 hypothetical protein NP_824514.1 4152374 R 227882 CDS NP_824515.1 29829881 1214410 complement(4153735..4154661) 1 NC_003155.4 DeoR family transcriptional regulator 4154661 1214410 SAV_3339 Streptomyces avermitilis MA-4680 DeoR family transcriptional regulator NP_824515.1 4153735 R 227882 CDS NP_824516.1 29829882 1214411 complement(4154875..4156302) 1 NC_003155.4 catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity; flavoprotein disulfide reductase 4156302 1214411 SAV_3340 Streptomyces avermitilis MA-4680 flavoprotein disulfide reductase NP_824516.1 4154875 R 227882 CDS NP_824517.1 29829883 1214412 4156420..4156857 1 NC_003155.4 hypothetical protein 4156857 1214412 SAV_3341 Streptomyces avermitilis MA-4680 hypothetical protein NP_824517.1 4156420 D 227882 CDS NP_824518.1 29829884 1210716 4157159..4157983 1 NC_003155.4 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 4157983 deoD 1210716 deoD Streptomyces avermitilis MA-4680 purine nucleoside phosphorylase NP_824518.1 4157159 D 227882 CDS NP_824519.1 29829885 1210717 4158185..4159816 1 NC_003155.4 phosphomannomutase 4159816 pmmB 1210717 pmmB Streptomyces avermitilis MA-4680 phosphomannomutase NP_824519.1 4158185 D 227882 CDS NP_824520.1 29829886 1214413 complement(4159993..4161672) 1 NC_003155.4 PF01545: Cation efflux family; hypothetical protein 4161672 1214413 SAV_3344 Streptomyces avermitilis MA-4680 hypothetical protein NP_824520.1 4159993 R 227882 CDS NP_824521.1 29829887 1214414 complement(4161915..4162571) 1 NC_003155.4 integral membrane protein 4162571 1214414 SAV_3345 Streptomyces avermitilis MA-4680 integral membrane protein NP_824521.1 4161915 R 227882 CDS NP_824522.1 29829888 1210718 4162733..4163722 1 NC_003155.4 deoxyribose-phosphate aldolase 4163722 deoC 1210718 deoC Streptomyces avermitilis MA-4680 deoxyribose-phosphate aldolase NP_824522.1 4162733 D 227882 CDS NP_824523.1 29829889 1214415 4163729..4165165 1 NC_003155.4 PF00171: Aldehyde dehydrogenase family; aldehyde dehydrogenase 4165165 1214415 SAV_3347 Streptomyces avermitilis MA-4680 aldehyde dehydrogenase NP_824523.1 4163729 D 227882 CDS NP_824524.1 29829890 1214416 4165158..4166066 1 NC_003155.4 PF00171: Aldehyde dehydrogenase family; aldehyde dehydrogenase 4166066 1214416 SAV_3348 Streptomyces avermitilis MA-4680 aldehyde dehydrogenase NP_824524.1 4165158 D 227882 CDS NP_824525.1 29829891 1214417 complement(4166279..4166674) 1 NC_003155.4 hypothetical protein 4166674 1214417 SAV_3349 Streptomyces avermitilis MA-4680 hypothetical protein NP_824525.1 4166279 R 227882 CDS NP_824526.1 29829892 1214418 4166728..4167432 1 NC_003155.4 ATP-binding protein 4167432 1214418 SAV_3350 Streptomyces avermitilis MA-4680 ATP-binding protein NP_824526.1 4166728 D 227882 CDS NP_824527.1 29829893 1210719 complement(4167629..4168249) 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 4168249 sig25 1210719 sig25 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_824527.1 4167629 R 227882 CDS NP_824528.1 29829894 1210720 4168730..4169407 1 NC_003155.4 PF00072: Response regulator receiver domain; two-component system response regulator 4169407 smrA 1210720 smrA Streptomyces avermitilis MA-4680 two-component system response regulator NP_824528.1 4168730 D 227882 CDS NP_824529.1 29829895 1210721 4169404..4170969 1 NC_003155.4 PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; two-component system sensor kinase 4170969 smrB 1210721 smrB Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_824529.1 4169404 D 227882 CDS NP_824530.1 29829896 1214419 4171002..4171631 1 NC_003155.4 lipoprotein 4171631 1214419 SAV_3354 Streptomyces avermitilis MA-4680 lipoprotein NP_824530.1 4171002 D 227882 CDS NP_824531.1 29829897 1214420 4171759..4172310 1 NC_003155.4 PF04892: VanZ like family; integral membrane protein 4172310 1214420 SAV_3355 Streptomyces avermitilis MA-4680 integral membrane protein NP_824531.1 4171759 D 227882 CDS NP_824532.1 29829898 1214421 4172399..4172602 1 NC_003155.4 PF04024: PspC domain; hypothetical protein 4172602 1214421 SAV_3356 Streptomyces avermitilis MA-4680 hypothetical protein NP_824532.1 4172399 D 227882 CDS NP_824533.1 29829899 1214422 complement(4172712..4173044) 1 NC_003155.4 protein 4173044 1214422 SAV_3357 Streptomyces avermitilis MA-4680 protein NP_824533.1 4172712 R 227882 CDS NP_824534.1 29829900 1210722 complement(4173175..4174389) 1 NC_003155.4 catalyzes the formation of inosine from adenosine; adenosine deaminase 4174389 add3 1210722 add3 Streptomyces avermitilis MA-4680 adenosine deaminase NP_824534.1 4173175 R 227882 CDS NP_824535.1 29829901 1214423 4174443..4175207 1 NC_003155.4 PF00326: Prolyl oligopeptidase family; hypothetical protein 4175207 1214423 SAV_3359 Streptomyces avermitilis MA-4680 hypothetical protein NP_824535.1 4174443 D 227882 CDS NP_824536.1 29829902 1214424 complement(4175295..4176248) 1 NC_003155.4 LysR family transcriptional regulator 4176248 1214424 SAV_3360 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_824536.1 4175295 R 227882 CDS NP_824537.1 29829903 1214425 4176312..4177604 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transport integral membrane protein 4177604 1214425 SAV_3361 Streptomyces avermitilis MA-4680 transport integral membrane protein NP_824537.1 4176312 D 227882 CDS NP_824538.1 29829904 1210723 4177745..4178875 1 NC_003155.4 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 4178875 dnaN2 1210723 dnaN2 Streptomyces avermitilis MA-4680 DNA polymerase III subunit beta NP_824538.1 4177745 D 227882 CDS NP_824539.1 29829905 1210724 4179014..4180018 1 NC_003155.4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; RNA polymerase factor sigma-70 4180018 sig26 1210724 sig26 Streptomyces avermitilis MA-4680 RNA polymerase factor sigma-70 NP_824539.1 4179014 D 227882 CDS NP_824540.1 29829906 1214426 complement(4179911..4180297) 1 NC_003155.4 hypothetical protein 4180297 1214426 SAV_3364 Streptomyces avermitilis MA-4680 hypothetical protein NP_824540.1 4179911 R 227882 CDS NP_824541.1 29829907 1210725 complement(4180427..4181710) 1 NC_003155.4 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 4181710 deoA 1210725 deoA Streptomyces avermitilis MA-4680 thymidine phosphorylase NP_824541.1 4180427 R 227882 CDS NP_824542.1 29829908 1210726 complement(4181779..4182195) 1 NC_003155.4 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 4182195 cdd2 1210726 cdd2 Streptomyces avermitilis MA-4680 cytidine deaminase NP_824542.1 4181779 R 227882 CDS NP_824543.1 29829909 1214427 complement(4182192..4183445) 1 NC_003155.4 sugar ABC transporter permease 4183445 1214427 SAV_3367 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_824543.1 4182192 R 227882 CDS NP_824544.1 29829910 1214428 complement(4183451..4184581) 1 NC_003155.4 PF02653: Branched-chain amino acid transport system / permease component; sugar ABC transporter permease 4184581 1214428 SAV_3368 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_824544.1 4183451 R 227882 CDS NP_824545.1 29829911 1214429 complement(4184578..4186161) 1 NC_003155.4 sugar ABC transporter ATP-binding protein 4186161 1214429 SAV_3369 Streptomyces avermitilis MA-4680 sugar ABC transporter ATP-binding protein NP_824545.1 4184578 R 227882 CDS NP_824546.1 29829912 1214430 complement(4186443..4187498) 1 NC_003155.4 PF02608: Basic membrane protein; lipoprotein 4187498 1214430 SAV_3370 Streptomyces avermitilis MA-4680 lipoprotein NP_824546.1 4186443 R 227882 CDS NP_824547.1 29829913 1214431 complement(4187781..4188854) 1 NC_003155.4 simple sugar transport system substrate-binding protein 4188854 1214431 SAV_7581 Streptomyces avermitilis MA-4680 simple sugar transport system substrate-binding protein NP_824547.1 4187781 R 227882 CDS NP_824548.1 29829914 1210727 complement(4189087..4190340) 1 NC_003155.4 PF01546: Peptidase family M20/M25/M40; metal-dependent amidase/aminoacylase/carboxypeptidase 4190340 1210727 SAV_3371 Streptomyces avermitilis MA-4680 metal-dependent amidase/aminoacylase/carboxypeptidase NP_824548.1 4189087 R 227882 CDS NP_824549.1 29829915 1214432 complement(4190713..4191786) 1 NC_003155.4 hypothetical protein 4191786 1214432 SAV_3372 Streptomyces avermitilis MA-4680 hypothetical protein NP_824549.1 4190713 R 227882 CDS NP_824550.1 29829916 1214433 complement(4191813..4192748) 1 NC_003155.4 N-acetylneuraminic acid (Neu5Ac) synthase 4192748 1214433 SAV_3373 Streptomyces avermitilis MA-4680 N-acetylneuraminic acid (Neu5Ac) synthase NP_824550.1 4191813 R 227882 CDS NP_824551.1 29829917 1214434 complement(4192762..4194060) 1 NC_003155.4 transferase 4194060 1214434 SAV_3374 Streptomyces avermitilis MA-4680 transferase NP_824551.1 4192762 R 227882 CDS NP_824552.1 29829918 1214435 complement(4194093..4195448) 1 NC_003155.4 hypothetical protein 4195448 1214435 SAV_3375 Streptomyces avermitilis MA-4680 hypothetical protein NP_824552.1 4194093 R 227882 CDS NP_824553.1 29829919 1214436 4195647..4196627 1 NC_003155.4 transferase 4196627 1214436 SAV_3376 Streptomyces avermitilis MA-4680 transferase NP_824553.1 4195647 D 227882 CDS NP_824554.1 29829920 1214437 4196624..4197958 1 NC_003155.4 hypothetical protein 4197958 1214437 SAV_3377 Streptomyces avermitilis MA-4680 hypothetical protein NP_824554.1 4196624 D 227882 CDS NP_824555.1 29829921 1214438 4197991..4199139 1 NC_003155.4 PF01757: Acyltransferase family; hypothetical protein 4199139 1214438 SAV_3378 Streptomyces avermitilis MA-4680 hypothetical protein NP_824555.1 4197991 D 227882 CDS NP_824556.1 29829922 1214439 complement(4199236..4199886) 1 NC_003155.4 TetR family transcriptional regulator 4199886 1214439 SAV_3379 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_824556.1 4199236 R 227882 CDS NP_824557.1 29829923 1214440 4199925..4201361 1 NC_003155.4 PF01360: Monooxygenase; hypothetical protein 4201361 1214440 SAV_3380 Streptomyces avermitilis MA-4680 hypothetical protein NP_824557.1 4199925 D 227882 CDS NP_824558.1 29829924 1214441 complement(4201358..4202011) 1 NC_003155.4 PF01810: LysE type translocator; leucine export protein LeuE 4202011 1214441 SAV_3381 Streptomyces avermitilis MA-4680 leucine export protein LeuE NP_824558.1 4201358 R 227882 CDS NP_824559.1 29829925 1210728 complement(4202111..4203691) 1 NC_003155.4 methylmalonyl-CoA mutase subunit alpha 4203691 mcmA2 1210728 mcmA2 Streptomyces avermitilis MA-4680 methylmalonyl-CoA mutase subunit alpha NP_824559.1 4202111 R 227882 CDS NP_824560.1 29829926 1214442 4203959..4204816 1 NC_003155.4 PF01471: Putative peptidoglycan binding domain; lipoprotein 4204816 1214442 SAV_3383 Streptomyces avermitilis MA-4680 lipoprotein NP_824560.1 4203959 D 227882 CDS NP_824561.1 29829927 1214443 complement(4205272..4206369) 1 NC_003155.4 hypothetical protein 4206369 1214443 SAV_3384 Streptomyces avermitilis MA-4680 hypothetical protein NP_824561.1 4205272 R 227882 CDS NP_824562.1 29829928 1210729 complement(4206366..4207079) 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 4207079 sig27 1210729 sig27 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_824562.1 4206366 R 227882 CDS NP_824563.1 29829929 1214444 complement(4207446..4208129) 1 NC_003155.4 hypothetical protein 4208129 1214444 SAV_3386 Streptomyces avermitilis MA-4680 hypothetical protein NP_824563.1 4207446 R 227882 CDS NP_824564.1 29829930 1210730 complement(4208154..4208843) 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 4208843 sig28 1210730 sig28 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_824564.1 4208154 R 227882 CDS NP_824565.1 29829931 1214445 4209033..4211747 1 NC_003155.4 PF01839: FG-GAP repeat; hypothetical protein 4211747 1214445 SAV_3388 Streptomyces avermitilis MA-4680 hypothetical protein NP_824565.1 4209033 D 227882 CDS NP_824566.1 29829932 1214446 complement(4211824..4212282) 1 NC_003155.4 hypothetical protein 4212282 1214446 SAV_3389 Streptomyces avermitilis MA-4680 hypothetical protein NP_824566.1 4211824 R 227882 CDS NP_824567.1 29829933 1214447 complement(4212357..4212917) 1 NC_003155.4 hypothetical protein 4212917 1214447 SAV_3390 Streptomyces avermitilis MA-4680 hypothetical protein NP_824567.1 4212357 R 227882 CDS NP_824568.1 29829934 1214448 complement(4213002..4213529) 1 NC_003155.4 hypothetical protein 4213529 1214448 SAV_3391 Streptomyces avermitilis MA-4680 hypothetical protein NP_824568.1 4213002 R 227882 CDS NP_824569.1 29829935 1214449 complement(4213630..4214691) 1 NC_003155.4 hypothetical protein 4214691 1214449 SAV_3392 Streptomyces avermitilis MA-4680 hypothetical protein NP_824569.1 4213630 R 227882 CDS NP_824570.1 29829936 1214450 complement(4214726..4216363) 1 NC_003155.4 beta-N-acetylglucosaminidase 4216363 nagZ2 1214450 nagZ2 Streptomyces avermitilis MA-4680 beta-N-acetylglucosaminidase NP_824570.1 4214726 R 227882 CDS NP_824571.1 29829937 1214451 4216717..4217205 1 NC_003155.4 putative OHCU decarboxylase 4217205 1214451 SAV_3394 Streptomyces avermitilis MA-4680 putative OHCU decarboxylase NP_824571.1 4216717 D 227882 CDS NP_824572.1 29829938 1210731 4217404..4217784 1 NC_003155.4 succinate dehydrogenase cytochrome b-556 subunit 4217784 sdhC 1210731 sdhC Streptomyces avermitilis MA-4680 succinate dehydrogenase cytochrome b-556 subunit NP_824572.1 4217404 D 227882 CDS NP_824573.1 29829939 1210732 4217790..4218272 1 NC_003155.4 succinate dehydrogenase hydrophobic membrane anchor protein 4218272 sdhD 1210732 sdhD Streptomyces avermitilis MA-4680 succinate dehydrogenase hydrophobic membrane anchor protein NP_824573.1 4217790 D 227882 CDS NP_824574.1 29829940 1210733 4218295..4220049 1 NC_003155.4 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 4220049 sdhA 1210733 sdhA Streptomyces avermitilis MA-4680 succinate dehydrogenase flavoprotein subunit NP_824574.1 4218295 D 227882 CDS NP_824575.1 29829941 1210734 4220049..4220822 1 NC_003155.4 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 4220822 sdhB 1210734 sdhB Streptomyces avermitilis MA-4680 succinate dehydrogenase iron-sulfur subunit NP_824575.1 4220049 D 227882 CDS NP_824576.1 29829942 1214452 complement(4220893..4221156) 1 NC_003155.4 PF05154: TM2 domain; hypothetical protein 4221156 1214452 SAV_3399 Streptomyces avermitilis MA-4680 hypothetical protein NP_824576.1 4220893 R 227882 CDS NP_824577.1 29829943 1214453 complement(4221425..4221835) 1 NC_003155.4 hypothetical protein 4221835 1214453 SAV_3400 Streptomyces avermitilis MA-4680 hypothetical protein NP_824577.1 4221425 R 227882 CDS NP_824578.1 29829944 1214454 complement(4221828..4222328) 1 NC_003155.4 PF05154: TM2 domain; hypothetical protein 4222328 1214454 SAV_3401 Streptomyces avermitilis MA-4680 hypothetical protein NP_824578.1 4221828 R 227882 CDS NP_824579.1 29829945 1214455 complement(4222417..4224888) 1 NC_003155.4 hypothetical protein 4224888 1214455 SAV_3402 Streptomyces avermitilis MA-4680 hypothetical protein NP_824579.1 4222417 R 227882 CDS NP_824580.1 29829946 1214456 complement(4224891..4225385) 1 NC_003155.4 hypothetical protein 4225385 1214456 SAV_3403 Streptomyces avermitilis MA-4680 hypothetical protein NP_824580.1 4224891 R 227882 CDS NP_824581.1 29829947 1214457 4225432..4225845 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein 4225845 1214457 SAV_3404 Streptomyces avermitilis MA-4680 hypothetical protein NP_824581.1 4225432 D 227882 CDS NP_824582.1 29829948 1214458 4226006..4226413 1 NC_003155.4 hypothetical protein 4226413 1214458 SAV_3405 Streptomyces avermitilis MA-4680 hypothetical protein NP_824582.1 4226006 D 227882 CDS NP_824583.1 29829949 1214459 4226410..4226928 1 NC_003155.4 PF04134: Protein of unknown function, DUF393; hypothetical protein 4226928 1214459 SAV_3406 Streptomyces avermitilis MA-4680 hypothetical protein NP_824583.1 4226410 D 227882 CDS NP_824584.1 29829950 1214460 4226939..4227736 1 NC_003155.4 TetR family transcriptional regulator 4227736 1214460 SAV_3407 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_824584.1 4226939 D 227882 CDS NP_824585.1 29829951 1214461 complement(4227749..4230178) 1 NC_003155.4 PF03176: MMPL family; integral membrane export protein 4230178 1214461 SAV_3408 Streptomyces avermitilis MA-4680 integral membrane export protein NP_824585.1 4227749 R 227882 CDS NP_824586.1 29829952 1214462 4230348..4231079 1 NC_003155.4 two-component system response regulator 4231079 1214462 SAV_3409 Streptomyces avermitilis MA-4680 two-component system response regulator NP_824586.1 4230348 D 227882 CDS NP_824587.1 29829953 1214463 4231076..4232521 1 NC_003155.4 two-component system sensor kinase 4232521 1214463 SAV_3410 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_824587.1 4231076 D 227882 CDS NP_824588.1 29829954 1214464 complement(4232582..4233871) 1 NC_003155.4 PF00149: Calcineurin-like phosphoesterase; hypothetical protein 4233871 1214464 SAV_3411 Streptomyces avermitilis MA-4680 hypothetical protein NP_824588.1 4232582 R 227882 CDS NP_824589.1 29829955 1214465 complement(4233904..4234146) 1 NC_003155.4 integral membrane protein 4234146 1214465 SAV_3412 Streptomyces avermitilis MA-4680 integral membrane protein NP_824589.1 4233904 R 227882 CDS NP_824590.1 29829956 1210735 4234250..4235593 1 NC_003155.4 PF00768: D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase 4235593 dacB 1210735 dacB Streptomyces avermitilis MA-4680 D-alanyl-D-alanine carboxypeptidase NP_824590.1 4234250 D 227882 CDS NP_824591.1 29829957 1214466 complement(4235541..4236575) 1 NC_003155.4 PF03631: Ribonuclease BN-like family; ribonuclease BN family membrane protein 4236575 1214466 SAV_3414 Streptomyces avermitilis MA-4680 ribonuclease BN family membrane protein NP_824591.1 4235541 R 227882 CDS NP_824592.1 29829958 1214467 4236669..4237433 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 4237433 1214467 SAV_3415 Streptomyces avermitilis MA-4680 dehydrogenase NP_824592.1 4236669 D 227882 CDS NP_824593.1 29829959 1214468 complement(4237848..4238429) 1 NC_003155.4 protein 4238429 1214468 SAV_3416 Streptomyces avermitilis MA-4680 protein NP_824593.1 4237848 R 227882 CDS NP_824594.1 29829960 1210736 complement(4238566..4239579) 1 NC_003155.4 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 4239579 trpS1 1210736 trpS1 Streptomyces avermitilis MA-4680 tryptophanyl-tRNA synthetase NP_824594.1 4238566 R 227882 CDS NP_824595.1 29829961 1214469 4239779..4240402 1 NC_003155.4 hypothetical protein 4240402 1214469 SAV_3418 Streptomyces avermitilis MA-4680 hypothetical protein NP_824595.1 4239779 D 227882 CDS NP_824596.1 29829962 1210737 complement(4240427..4241875) 1 NC_003155.4 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 4241875 glyA 1210737 glyA Streptomyces avermitilis MA-4680 serine hydroxymethyltransferase NP_824596.1 4240427 R 227882 CDS NP_824597.1 29829963 1210738 4242088..4243341 1 NC_003155.4 ornithine aminotransferase 4243341 rocD1 1210738 rocD1 Streptomyces avermitilis MA-4680 ornithine aminotransferase NP_824597.1 4242088 D 227882 CDS NP_824598.1 29829964 1214470 complement(4243356..4244543) 1 NC_003155.4 glutathionylspermidine synthase 4244543 1214470 SAV_3421 Streptomyces avermitilis MA-4680 glutathionylspermidine synthase NP_824598.1 4243356 R 227882 CDS NP_824599.1 29829965 1214471 complement(4244574..4244936) 1 NC_003155.4 hypothetical protein 4244936 1214471 SAV_3422 Streptomyces avermitilis MA-4680 hypothetical protein NP_824599.1 4244574 R 227882 CDS NP_824600.1 29829966 1214472 4245054..4245878 1 NC_003155.4 PF00892: Integral membrane protein DUF6; integral membrane protein 4245878 1214472 SAV_3423 Streptomyces avermitilis MA-4680 integral membrane protein NP_824600.1 4245054 D 227882 CDS NP_824601.1 29829967 1214473 complement(4245920..4246339) 1 NC_003155.4 regulatory protein 4246339 1214473 SAV_3424 Streptomyces avermitilis MA-4680 regulatory protein NP_824601.1 4245920 R 227882 CDS NP_824602.1 29829968 1214474 4246533..4247384 1 NC_003155.4 DNA-binding protein 4247384 1214474 SAV_3425 Streptomyces avermitilis MA-4680 DNA-binding protein NP_824602.1 4246533 D 227882 CDS NP_824603.1 29829969 1214475 4247394..4247594 1 NC_003155.4 PF04149: Domain of unknown function (DUF397); hypothetical protein 4247594 1214475 SAV_3426 Streptomyces avermitilis MA-4680 hypothetical protein NP_824603.1 4247394 D 227882 CDS NP_824604.1 29829970 1214476 complement(4247635..4249071) 1 NC_003155.4 GntR family transcriptional regulator 4249071 1214476 SAV_3427 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_824604.1 4247635 R 227882 CDS NP_824605.1 29829971 1214477 4249119..4249640 1 NC_003155.4 PF02627: Carboxymuconolactone decarboxylase family; hypothetical protein 4249640 1214477 SAV_3428 Streptomyces avermitilis MA-4680 hypothetical protein NP_824605.1 4249119 D 227882 CDS NP_824606.1 29829972 1214478 4249762..4250478 1 NC_003155.4 transferase 4250478 1214478 SAV_3429 Streptomyces avermitilis MA-4680 transferase NP_824606.1 4249762 D 227882 CDS NP_824607.1 29829973 1214479 complement(4250525..4251499) 1 NC_003155.4 glycine betaine-binding lipoprotein 4251499 1214479 SAV_3430 Streptomyces avermitilis MA-4680 glycine betaine-binding lipoprotein NP_824607.1 4250525 R 227882 CDS NP_824608.1 29829974 1214480 complement(4251501..4253444) 1 NC_003155.4 glycine/betaine ABC transporter permease 4253444 1214480 SAV_3431 Streptomyces avermitilis MA-4680 glycine/betaine ABC transporter permease NP_824608.1 4251501 R 227882 CDS NP_824609.1 29829975 1214481 complement(4253444..4254613) 1 NC_003155.4 glycine/betaine ABC transporter ATP-binding protein 4254613 1214481 SAV_3432 Streptomyces avermitilis MA-4680 glycine/betaine ABC transporter ATP-binding protein NP_824609.1 4253444 R 227882 CDS NP_824610.1 29829976 1214482 complement(4254610..4256160) 1 NC_003155.4 PF00732: GMC oxidoreductase; oxidoreductase 4256160 1214482 SAV_3433 Streptomyces avermitilis MA-4680 oxidoreductase NP_824610.1 4254610 R 227882 CDS NP_824611.1 29829977 1210739 complement(4256271..4257800) 1 NC_003155.4 glycine betaine aldehyde dehydrogenase 4257800 gbsA2 1210739 gbsA2 Streptomyces avermitilis MA-4680 glycine betaine aldehyde dehydrogenase NP_824611.1 4256271 R 227882 CDS NP_824612.1 29829978 1214483 complement(4258097..4259335) 1 NC_003155.4 PF04554: Extensin-like region; hypothetical protein 4259335 1214483 SAV_3435 Streptomyces avermitilis MA-4680 hypothetical protein NP_824612.1 4258097 R 227882 CDS NP_824613.1 29829979 1210740 complement(4259507..4260496) 1 NC_003155.4 catalyzes the oxidation of malate to oxaloacetate; malate dehydrogenase 4260496 mdh 1210740 mdh Streptomyces avermitilis MA-4680 malate dehydrogenase NP_824613.1 4259507 R 227882 CDS NP_824614.1 29829980 1214484 complement(4261015..4262277) 1 NC_003155.4 PF01381: Helix-turn-helix; hypothetical protein 4262277 1214484 SAV_3437 Streptomyces avermitilis MA-4680 hypothetical protein NP_824614.1 4261015 R 227882 CDS NP_824615.1 29829981 1214485 complement(4262617..4263129) 1 NC_003155.4 hypothetical protein 4263129 1214485 SAV_3438 Streptomyces avermitilis MA-4680 hypothetical protein NP_824615.1 4262617 R 227882 CDS NP_824616.1 29829982 1214486 4263664..4264200 1 NC_003155.4 hypothetical protein 4264200 1214486 SAV_3439 Streptomyces avermitilis MA-4680 hypothetical protein NP_824616.1 4263664 D 227882 CDS NP_824617.1 29829983 1214487 complement(4264282..4264899) 1 NC_003155.4 hypothetical protein 4264899 1214487 SAV_3440 Streptomyces avermitilis MA-4680 hypothetical protein NP_824617.1 4264282 R 227882 CDS NP_824618.1 29829984 1214488 complement(4265174..4265803) 1 NC_003155.4 hypothetical protein 4265803 1214488 SAV_3441 Streptomyces avermitilis MA-4680 hypothetical protein NP_824618.1 4265174 R 227882 CDS NP_824619.1 29829985 1210741 complement(4265904..4266758) 1 NC_003155.4 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 4266758 folD1 1210741 folD1 Streptomyces avermitilis MA-4680 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase NP_824619.1 4265904 R 227882 CDS NP_824620.1 29829986 1214489 4267000..4267671 1 NC_003155.4 PF06271: RDD family; hypothetical protein 4267671 1214489 SAV_3443 Streptomyces avermitilis MA-4680 hypothetical protein NP_824620.1 4267000 D 227882 CDS NP_824621.1 29829987 1210742 complement(4267834..4269417) 1 NC_003155.4 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 4269417 purH 1210742 purH Streptomyces avermitilis MA-4680 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase NP_824621.1 4267834 R 227882 CDS NP_824622.1 29829988 1210743 complement(4269414..4270043) 1 NC_003155.4 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 4270043 purN 1210743 purN Streptomyces avermitilis MA-4680 phosphoribosylglycinamide formyltransferase NP_824622.1 4269414 R 227882 CDS NP_824623.1 29829989 1214490 4270386..4271324 1 NC_003155.4 hypothetical protein 4271324 1214490 SAV_3446 Streptomyces avermitilis MA-4680 hypothetical protein NP_824623.1 4270386 D 227882 CDS NP_824624.1 29829990 1214491 complement(4271414..4271809) 1 NC_003155.4 hypothetical protein 4271809 1214491 SAV_3447 Streptomyces avermitilis MA-4680 hypothetical protein NP_824624.1 4271414 R 227882 CDS NP_824625.1 29829991 1214492 complement(4271816..4272148) 1 NC_003155.4 hypothetical protein 4272148 1214492 SAV_3448 Streptomyces avermitilis MA-4680 hypothetical protein NP_824625.1 4271816 R 227882 CDS NP_824626.1 29829992 1214493 complement(4272171..4273145) 1 NC_003155.4 integral membrane protein 4273145 1214493 SAV_3449 Streptomyces avermitilis MA-4680 integral membrane protein NP_824626.1 4272171 R 227882 CDS NP_824627.1 29829993 1214494 4273338..4274450 1 NC_003155.4 hypothetical protein 4274450 1214494 SAV_3450 Streptomyces avermitilis MA-4680 hypothetical protein NP_824627.1 4273338 D 227882 CDS NP_824628.1 29829994 1210744 complement(4274601..4275485) 1 NC_003155.4 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 4275485 sucD2 1210744 sucD2 Streptomyces avermitilis MA-4680 succinyl-CoA synthetase subunit alpha NP_824628.1 4274601 R 227882 CDS NP_824629.1 29829995 1210745 complement(4275507..4276685) 1 NC_003155.4 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 4276685 sucC 1210745 sucC Streptomyces avermitilis MA-4680 succinyl-CoA synthetase subunit beta NP_824629.1 4275507 R 227882 CDS NP_824630.1 29829996 1214495 complement(4277143..4279029) 1 NC_003155.4 threonine-rich protein; hypothetical protein 4279029 1214495 SAV_3453 Streptomyces avermitilis MA-4680 hypothetical protein NP_824630.1 4277143 R 227882 CDS NP_824631.1 29829997 1214496 complement(4279317..4280501) 1 NC_003155.4 hypothetical protein 4280501 1214496 SAV_3454 Streptomyces avermitilis MA-4680 hypothetical protein NP_824631.1 4279317 R 227882 CDS NP_824632.1 29829998 1214497 complement(4280661..4281710) 1 NC_003155.4 PF05762: VWA domain containing CoxE-like protein; hypothetical protein 4281710 1214497 SAV_3455 Streptomyces avermitilis MA-4680 hypothetical protein NP_824632.1 4280661 R 227882 CDS NP_824633.1 29829999 1214498 complement(4281929..4284355) 1 NC_003155.4 hypothetical protein 4284355 1214498 SAV_3456 Streptomyces avermitilis MA-4680 hypothetical protein NP_824633.1 4281929 R 227882 CDS NP_824634.1 29830000 1214499 complement(4284524..4285732) 1 NC_003155.4 PF07728: ATPase family associated with various cellular activities (AAA); MoxR-like ATPase 4285732 1214499 SAV_3457 Streptomyces avermitilis MA-4680 MoxR-like ATPase NP_824634.1 4284524 R 227882 CDS NP_824635.1 29830001 1214500 4286007..4287221 1 NC_003155.4 PF04434: SWIM zinc finger; hypothetical protein 4287221 1214500 SAV_3458 Streptomyces avermitilis MA-4680 hypothetical protein NP_824635.1 4286007 D 227882 CDS NP_824636.1 29830002 1214501 4287278..4288918 1 NC_003155.4 hypothetical protein 4288918 1214501 SAV_3459 Streptomyces avermitilis MA-4680 hypothetical protein NP_824636.1 4287278 D 227882 CDS NP_824637.1 29830003 1210746 complement(4289212..4289628) 1 NC_003155.4 isobutyryl-CoA mutase subunit B 4289628 icmB 1210746 icmB Streptomyces avermitilis MA-4680 isobutyryl-CoA mutase subunit B NP_824637.1 4289212 R 227882 CDS NP_824638.1 29830004 1214502 4290165..4291025 1 NC_003155.4 lipase 4291025 1214502 SAV_3461 Streptomyces avermitilis MA-4680 lipase NP_824638.1 4290165 D 227882 CDS NP_824639.1 29830005 1214503 4291312..4292910 1 NC_003155.4 PF01551: Peptidase family M23; peptidase 4292910 1214503 SAV_3462 Streptomyces avermitilis MA-4680 peptidase NP_824639.1 4291312 D 227882 CDS NP_824640.1 29830006 1210747 complement(4293057..4295642) 1 NC_003155.4 ATP-dependent DNA helicase 4295642 uvrD1 1210747 uvrD1 Streptomyces avermitilis MA-4680 ATP-dependent DNA helicase NP_824640.1 4293057 R 227882 CDS NP_824641.1 29830007 1214504 4296320..4297516 1 NC_003155.4 Seems to have no N-terminal signal sequence; NLP/P60-family protein 4297516 1214504 SAV_3464 Streptomyces avermitilis MA-4680 NLP/P60-family protein NP_824641.1 4296320 D 227882 CDS NP_824642.1 29830008 1214505 4297586..4298611 1 NC_003155.4 PF03595: C4-dicarboxylate transporter/malic acid transport protein; integral membrane protein 4298611 1214505 SAV_3465 Streptomyces avermitilis MA-4680 integral membrane protein NP_824642.1 4297586 D 227882 CDS NP_824643.1 29830009 1214506 complement(4298589..4298942) 1 NC_003155.4 integral membrane protein 4298942 1214506 SAV_3466 Streptomyces avermitilis MA-4680 integral membrane protein NP_824643.1 4298589 R 227882 CDS NP_824644.1 29830010 1214507 4299352..4300428 1 NC_003155.4 NLP/P60-family protein 4300428 1214507 SAV_3467 Streptomyces avermitilis MA-4680 NLP/P60-family protein NP_824644.1 4299352 D 227882 CDS NP_824645.1 29830011 1214508 4300610..4301392 1 NC_003155.4 hypothetical protein 4301392 1214508 SAV_3468 Streptomyces avermitilis MA-4680 hypothetical protein NP_824645.1 4300610 D 227882 CDS NP_824646.1 29830012 1214509 complement(4301418..4301591) 1 NC_003155.4 hypothetical protein 4301591 1214509 SAV_3469 Streptomyces avermitilis MA-4680 hypothetical protein NP_824646.1 4301418 R 227882 CDS NP_824647.1 29830013 1214510 complement(4301738..4302469) 1 NC_003155.4 two-component system response regulator 4302469 1214510 SAV_3470 Streptomyces avermitilis MA-4680 two-component system response regulator NP_824647.1 4301738 R 227882 CDS NP_824648.1 29830014 1214511 complement(4302466..4303755) 1 NC_003155.4 two-component system sensor kinase 4303755 1214511 SAV_3471 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_824648.1 4302466 R 227882 CDS NP_824649.1 29830015 1214512 4303934..4305370 1 NC_003155.4 PF04024: PspC domain; hypothetical protein 4305370 1214512 SAV_3472 Streptomyces avermitilis MA-4680 hypothetical protein NP_824649.1 4303934 D 227882 CDS NP_824650.1 29830016 1214513 4305357..4305617 1 NC_003155.4 hypothetical protein 4305617 1214513 SAV_3473 Streptomyces avermitilis MA-4680 hypothetical protein NP_824650.1 4305357 D 227882 CDS NP_824651.1 29830017 1214514 complement(4305813..4306331) 1 NC_003155.4 PF07681: DoxX; hypothetical protein 4306331 1214514 SAV_3474 Streptomyces avermitilis MA-4680 hypothetical protein NP_824651.1 4305813 R 227882 CDS NP_824652.1 29830018 1214515 complement(4306512..4307801) 1 NC_003155.4 hypothetical protein 4307801 1214515 SAV_3475 Streptomyces avermitilis MA-4680 hypothetical protein NP_824652.1 4306512 R 227882 CDS NP_824653.1 29830019 1214516 4308124..4309002 1 NC_003155.4 hypothetical protein 4309002 1214516 SAV_3476 Streptomyces avermitilis MA-4680 hypothetical protein NP_824653.1 4308124 D 227882 CDS NP_824654.1 29830020 1214517 complement(4309008..4309829) 1 NC_003155.4 hypothetical protein 4309829 fucA1 1214517 fucA1 Streptomyces avermitilis MA-4680 hypothetical protein NP_824654.1 4309008 R 227882 CDS NP_824655.1 29830021 1214518 4310058..4310534 1 NC_003155.4 PF01243: Pyridoxamine 5'-phosphate oxidase; hypothetical protein 4310534 1214518 SAV_3478 Streptomyces avermitilis MA-4680 hypothetical protein NP_824655.1 4310058 D 227882 CDS NP_824656.1 29830022 1210748 complement(4310567..4312144) 1 NC_003155.4 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 4312144 guaA 1210748 guaA Streptomyces avermitilis MA-4680 GMP synthase NP_824656.1 4310567 R 227882 CDS NP_824657.1 29830023 1214519 complement(4312291..4313571) 1 NC_003155.4 two-component system sensor kinase 4313571 1214519 SAV_3480 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_824657.1 4312291 R 227882 CDS NP_824658.1 29830024 1214520 complement(4313612..4314289) 1 NC_003155.4 two-component system response regulator 4314289 1214520 SAV_3481 Streptomyces avermitilis MA-4680 two-component system response regulator NP_824658.1 4313612 R 227882 CDS NP_824659.1 29830025 1214521 4314888..4316384 1 NC_003155.4 PF00854: POT family; di-tripeptide transporter 4316384 1214521 SAV_3482 Streptomyces avermitilis MA-4680 di-tripeptide transporter NP_824659.1 4314888 D 227882 CDS NP_824660.1 29830026 1214522 complement(4316481..4317110) 1 NC_003155.4 phosphoglycerate mutase 4317110 1214522 SAV_3483 Streptomyces avermitilis MA-4680 phosphoglycerate mutase NP_824660.1 4316481 R 227882 CDS NP_824661.1 29830027 1214523 complement(4317304..4318536) 1 NC_003155.4 hypothetical protein 4318536 1214523 SAV_3484 Streptomyces avermitilis MA-4680 hypothetical protein NP_824661.1 4317304 R 227882 CDS NP_824662.1 29830028 1214524 complement(4318608..4319714) 1 NC_003155.4 hypothetical protein 4319714 1214524 SAV_3485 Streptomyces avermitilis MA-4680 hypothetical protein NP_824662.1 4318608 R 227882 CDS NP_824663.1 29830029 1214525 complement(4319729..4320781) 1 NC_003155.4 hypothetical protein 4320781 1214525 SAV_3486 Streptomyces avermitilis MA-4680 hypothetical protein NP_824663.1 4319729 R 227882 CDS NP_824664.1 29830030 1214526 complement(4320873..4321568) 1 NC_003155.4 PF00746: Gram positive anchor; hypothetical protein 4321568 1214526 SAV_3487 Streptomyces avermitilis MA-4680 hypothetical protein NP_824664.1 4320873 R 227882 CDS NP_824665.1 29830031 1214527 complement(4321740..4322399) 1 NC_003155.4 similar to sigma factor regulator prsI; regulator protein 4322399 1214527 SAV_3488 Streptomyces avermitilis MA-4680 regulator protein NP_824665.1 4321740 R 227882 CDS NP_824666.1 29830032 1214528 complement(4322655..4323023) 1 NC_003155.4 PF01740: STAS domain; anti-sigma factor antagonist 4323023 1214528 SAV_3489 Streptomyces avermitilis MA-4680 anti-sigma factor antagonist NP_824666.1 4322655 R 227882 CDS NP_824667.1 29830033 1210749 4323274..4324194 1 NC_003155.4 RNA polymerase alternative sigma factor; RNA polymerase sigma factor 4324194 sig29 1210749 sig29 Streptomyces avermitilis MA-4680 RNA polymerase sigma factor NP_824667.1 4323274 D 227882 CDS NP_824668.1 29830034 1214529 4324523..4326172 1 NC_003155.4 PF00652: QXW lectin repeat; hypothetical protein 4326172 1214529 SAV_3491 Streptomyces avermitilis MA-4680 hypothetical protein NP_824668.1 4324523 D 227882 CDS NP_824669.1 29830035 1214530 4326262..4326837 1 NC_003155.4 hypothetical protein 4326837 1214530 SAV_3492 Streptomyces avermitilis MA-4680 hypothetical protein NP_824669.1 4326262 D 227882 CDS NP_824670.1 29830036 1210750 complement(4326856..4328100) 1 NC_003155.4 catalyzes the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway; imidazolonepropionase 4328100 hutI 1210750 hutI Streptomyces avermitilis MA-4680 imidazolonepropionase NP_824670.1 4326856 R 227882 CDS NP_824671.1 29830037 1214531 complement(4328136..4329470) 1 NC_003155.4 catalyzes the deimination of N-formimino-L-glutamate to ammonia and N-formyl-L-glutamate; N-formimino-L-glutamate deiminase 4329470 1214531 SAV_3494 Streptomyces avermitilis MA-4680 N-formimino-L-glutamate deiminase NP_824671.1 4328136 R 227882 CDS NP_824672.1 29830038 1214532 complement(4329467..4330708) 1 NC_003155.4 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase 4330708 1214532 SAV_3495 Streptomyces avermitilis MA-4680 allantoate amidohydrolase NP_824672.1 4329467 R 227882 CDS NP_824673.1 29830039 1210751 complement(4330705..4332369) 1 NC_003155.4 catalyzes the formation of 4-imidazolone-5-propanoate from urocanate during histidine metabolism; urocanate hydratase 4332369 hutU 1210751 hutU Streptomyces avermitilis MA-4680 urocanate hydratase NP_824673.1 4330705 R 227882 CDS NP_824674.1 29830040 1214533 4332475..4333932 1 NC_003155.4 PF02784: Pyridoxal-dependent decarboxylase, pyridoxal binding domain; lysine/ornithine decarboxylase 4333932 1214533 SAV_3497 Streptomyces avermitilis MA-4680 lysine/ornithine decarboxylase NP_824674.1 4332475 D 227882 CDS NP_824675.1 29830041 1214534 4334240..4334635 1 NC_003155.4 hypothetical protein 4334635 1214534 SAV_3498 Streptomyces avermitilis MA-4680 hypothetical protein NP_824675.1 4334240 D 227882 CDS NP_824676.1 29830042 1214535 4334632..4335756 1 NC_003155.4 hypothetical protein 4335756 1214535 SAV_3499 Streptomyces avermitilis MA-4680 hypothetical protein NP_824676.1 4334632 D 227882 CDS NP_824677.1 29830043 1214536 4335795..4336316 1 NC_003155.4 PF03259: Roadblock/LC7 domain; hypothetical protein 4336316 1214536 SAV_3500 Streptomyces avermitilis MA-4680 hypothetical protein NP_824677.1 4335795 D 227882 CDS NP_824678.1 29830044 1214537 4336331..4336705 1 NC_003155.4 hypothetical protein 4336705 1214537 SAV_3501 Streptomyces avermitilis MA-4680 hypothetical protein NP_824678.1 4336331 D 227882 CDS NP_824679.1 29830045 1214538 complement(4336713..4337297) 1 NC_003155.4 integral membrane protein 4337297 1214538 SAV_3502 Streptomyces avermitilis MA-4680 integral membrane protein NP_824679.1 4336713 R 227882 CDS NP_824680.1 29830046 1214539 complement(4337483..4338343) 1 NC_003155.4 transcriptional regulator 4338343 1214539 SAV_3503 Streptomyces avermitilis MA-4680 transcriptional regulator NP_824680.1 4337483 R 227882 CDS NP_824681.1 29830047 1210752 complement(4338340..4339986) 1 NC_003155.4 EC:4.3.1.3; histidine ammonia-lyase 4339986 hutH2 1210752 hutH2 Streptomyces avermitilis MA-4680 histidine ammonia-lyase NP_824681.1 4338340 R 227882 CDS NP_824682.1 29830048 1214540 4340087..4341157 1 NC_003155.4 ABC transporter ATP-binding protein 4341157 1214540 SAV_3505 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_824682.1 4340087 D 227882 CDS NP_824683.1 29830049 1214541 4341154..4341795 1 NC_003155.4 ABC transporter permease 4341795 1214541 SAV_3506 Streptomyces avermitilis MA-4680 ABC transporter permease NP_824683.1 4341154 D 227882 CDS NP_824684.1 29830050 1214542 4341774..4342493 1 NC_003155.4 ABC transporter permease 4342493 1214542 SAV_3507 Streptomyces avermitilis MA-4680 ABC transporter permease NP_824684.1 4341774 D 227882 CDS NP_824685.1 29830051 1214543 4342514..4343452 1 NC_003155.4 ABC transporter substrate-binding protein 4343452 1214543 SAV_3508 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_824685.1 4342514 D 227882 CDS NP_824686.1 29830052 1214544 4343554..4343979 1 NC_003155.4 hypothetical protein 4343979 1214544 SAV_3509 Streptomyces avermitilis MA-4680 hypothetical protein NP_824686.1 4343554 D 227882 CDS NP_824687.1 29830053 1210753 complement(4344378..4345772) 1 NC_003155.4 cystathionine beta-synthase 4345772 cysM1 1210753 cysM1 Streptomyces avermitilis MA-4680 cystathionine beta-synthase NP_824687.1 4344378 R 227882 CDS NP_824688.1 29830054 1214545 4345918..4346958 1 NC_003155.4 PF00657: GDSL-like Lipase/Acylhydrolase; protein 4346958 1214545 SAV_3511 Streptomyces avermitilis MA-4680 protein NP_824688.1 4345918 D 227882 CDS NP_824689.1 29830055 1210754 4347182..4348405 1 NC_003155.4 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 4348405 fadA2 1210754 fadA2 Streptomyces avermitilis MA-4680 acetyl-CoA acetyltransferase NP_824689.1 4347182 D 227882 CDS NP_824690.1 29830056 1214546 4348715..4349512 1 NC_003155.4 protein 4349512 1214546 SAV_3513 Streptomyces avermitilis MA-4680 protein NP_824690.1 4348715 D 227882 CDS NP_824691.1 29830057 1214547 complement(4349555..4349866) 1 NC_003155.4 hypothetical protein 4349866 1214547 SAV_3514 Streptomyces avermitilis MA-4680 hypothetical protein NP_824691.1 4349555 R 227882 CDS NP_824692.1 29830058 1214548 4349971..4350201 1 NC_003155.4 hypothetical protein 4350201 1214548 SAV_3515 Streptomyces avermitilis MA-4680 hypothetical protein NP_824692.1 4349971 D 227882 CDS NP_824693.1 29830059 1214549 complement(4350300..4351181) 1 NC_003155.4 PF06539: Protein of unknown function (DUF1112); integral membrane protein 4351181 1214549 SAV_3516 Streptomyces avermitilis MA-4680 integral membrane protein NP_824693.1 4350300 R 227882 CDS NP_824694.1 29830060 1210755 complement(4351218..4352609) 1 NC_003155.4 catalyzes the formation of protocatechuate from 4-hydroxybenzoate; 4-hydroxybenzoate 3-monooxygenase 4352609 pobA 1210755 pobA Streptomyces avermitilis MA-4680 4-hydroxybenzoate 3-monooxygenase NP_824694.1 4351218 R 227882 CDS NP_824695.1 29830061 1214550 complement(4352756..4353613) 1 NC_003155.4 PF01040: UbiA prenyltransferase family; hypothetical protein 4353613 1214550 SAV_3518 Streptomyces avermitilis MA-4680 hypothetical protein NP_824695.1 4352756 R 227882 CDS NP_824696.1 29830062 1210756 complement(4353631..4355043) 1 NC_003155.4 CYP107V1, pobA is located at downstream; cytochrome P450 hydroxylase 4355043 cyp15 1210756 cyp15 Streptomyces avermitilis MA-4680 cytochrome P450 hydroxylase NP_824696.1 4353631 R 227882 CDS NP_824697.1 29830063 1214551 complement(4355040..4355435) 1 NC_003155.4 hypothetical protein 4355435 1214551 SAV_3520 Streptomyces avermitilis MA-4680 hypothetical protein NP_824697.1 4355040 R 227882 CDS NP_824698.1 29830064 1214552 complement(4355459..4356544) 1 NC_003155.4 3-oxoacyl-ACP synthase III 4356544 1214552 SAV_3521 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP synthase III NP_824698.1 4355459 R 227882 CDS NP_824699.1 29830065 1210757 complement(4356548..4359637) 1 NC_003155.4 phosphoenolpyruvate synthase 4359637 ppsA 1210757 ppsA Streptomyces avermitilis MA-4680 phosphoenolpyruvate synthase NP_824699.1 4356548 R 227882 CDS NP_824700.1 29830066 1214553 complement(4359641..4360282) 1 NC_003155.4 PF04140: Isoprenylcysteine carboxyl methyltransferase (ICMT) family; hypothetical protein 4360282 1214553 SAV_3523 Streptomyces avermitilis MA-4680 hypothetical protein NP_824700.1 4359641 R 227882 CDS NP_824701.1 29830067 1214554 complement(4360279..4361172) 1 NC_003155.4 hypothetical protein 4361172 1214554 SAV_3524 Streptomyces avermitilis MA-4680 hypothetical protein NP_824701.1 4360279 R 227882 CDS NP_824702.1 29830068 1214555 4361587..4362429 1 NC_003155.4 hypothetical protein 4362429 1214555 SAV_3525 Streptomyces avermitilis MA-4680 hypothetical protein NP_824702.1 4361587 D 227882 CDS NP_824703.1 29830069 1214556 4363118..4363888 1 NC_003155.4 ABC transporter ATP-binding protein 4363888 1214556 SAV_3526 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_824703.1 4363118 D 227882 CDS NP_824704.1 29830070 1214557 4363962..4366490 1 NC_003155.4 ABC transporter permease 4366490 1214557 SAV_3527 Streptomyces avermitilis MA-4680 ABC transporter permease NP_824704.1 4363962 D 227882 CDS NP_824705.1 29830071 1210759 complement(4366558..4367847) 1 NC_003155.4 cyclopropane fatty acid synthase 4367847 cfa 1210759 cfa Streptomyces avermitilis MA-4680 cyclopropane fatty acid synthase NP_824705.1 4366558 R 227882 CDS NP_824706.1 29830072 1214558 complement(4368052..4369359) 1 NC_003155.4 PF00070: Pyridine nucleotide-disulphide oxidoreductase; NADH dehydrogenase 4369359 ndh2 1214558 ndh2 Streptomyces avermitilis MA-4680 NADH dehydrogenase NP_824706.1 4368052 R 227882 CDS NP_824707.1 29830073 1214559 complement(4370029..4370970) 1 NC_003155.4 PF02541: Ppx/GppA phosphatase family; exopolyphosphatase 4370970 ppx1 1214559 ppx1 Streptomyces avermitilis MA-4680 exopolyphosphatase NP_824707.1 4370029 R 227882 CDS NP_824708.1 29830074 1214560 complement(4371105..4371629) 1 NC_003155.4 PF04417: Protein of unknown function (DUF501); hypothetical protein 4371629 1214560 SAV_3531 Streptomyces avermitilis MA-4680 hypothetical protein NP_824708.1 4371105 R 227882 CDS NP_824709.1 29830075 1214561 complement(4371658..4372152) 1 NC_003155.4 PF04977: Septum formation initiator; hypothetical protein 4372152 1214561 SAV_3532 Streptomyces avermitilis MA-4680 hypothetical protein NP_824709.1 4371658 R 227882 CDS NP_824710.1 29830076 1210760 complement(4372251..4373537) 1 NC_003155.4 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 4373537 eno 1210760 eno Streptomyces avermitilis MA-4680 phosphopyruvate hydratase NP_824710.1 4372251 R 227882 CDS NP_824711.1 29830077 1214562 complement(4373879..4374562) 1 NC_003155.4 PF06737: Transglycosylase-like domain; protein 4374562 1214562 SAV_3534 Streptomyces avermitilis MA-4680 protein NP_824711.1 4373879 R 227882 CDS NP_824712.1 29830078 1214563 complement(4374923..4375882) 1 NC_003155.4 PF06737: Transglycosylase-like domain; protein 4375882 1214563 SAV_3535 Streptomyces avermitilis MA-4680 protein NP_824712.1 4374923 R 227882 CDS NP_824713.1 29830079 1210761 4376290..4377663 1 NC_003155.4 CYP107U2; cytochrome P450 4377663 1210761 SAV_3536 Streptomyces avermitilis MA-4680 cytochrome P450 NP_824713.1 4376290 D 227882 CDS NP_824714.1 29830080 1214564 complement(4377718..4378752) 1 NC_003155.4 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase 4378752 1214564 SAV_3537 Streptomyces avermitilis MA-4680 nucleoside triphosphate pyrophosphohydrolase NP_824714.1 4377718 R 227882 CDS NP_824715.1 29830081 1214565 complement(4378947..4379606) 1 NC_003155.4 lipoprotein 4379606 1214565 SAV_3538 Streptomyces avermitilis MA-4680 lipoprotein NP_824715.1 4378947 R 227882 CDS NP_824716.1 29830082 1214566 complement(4379753..4380481) 1 NC_003155.4 hypothetical protein 4380481 1214566 SAV_3539 Streptomyces avermitilis MA-4680 hypothetical protein NP_824716.1 4379753 R 227882 CDS NP_824717.1 29830083 1210762 complement(4380736..4382199) 1 NC_003155.4 serine/threonine protein kinase 4382199 pkn6 1210762 pkn6 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_824717.1 4380736 R 227882 CDS NP_824718.1 29830084 1214567 complement(4382265..4382855) 1 NC_003155.4 integral membrane protein 4382855 1214567 SAV_3541 Streptomyces avermitilis MA-4680 integral membrane protein NP_824718.1 4382265 R 227882 CDS NP_824719.1 29830085 1214568 complement(4383011..4385047) 1 NC_003155.4 weak homology to hsdM; type II restriction-modification system DNA adenine-specific methylase 4385047 savM1 1214568 savM1 Streptomyces avermitilis MA-4680 type II restriction-modification system DNA adenine-specific methylase NP_824719.1 4383011 R 227882 CDS NP_824720.1 29830086 1214569 4385750..4386499 1 NC_003155.4 lipoprotein 4386499 1214569 SAV_3543 Streptomyces avermitilis MA-4680 lipoprotein NP_824720.1 4385750 D 227882 CDS NP_824721.1 29830087 1214570 complement(4386709..4387428) 1 NC_003155.4 lipoprotein 4387428 1214570 SAV_3544 Streptomyces avermitilis MA-4680 lipoprotein NP_824721.1 4386709 R 227882 CDS NP_824722.1 29830088 1214571 complement(4387621..4388547) 1 NC_003155.4 hypothetical protein 4388547 1214571 SAV_3545 Streptomyces avermitilis MA-4680 hypothetical protein NP_824722.1 4387621 R 227882 CDS NP_824723.1 29830089 1214572 4388666..4389268 1 NC_003155.4 TetR family transcriptional regulator 4389268 1214572 SAV_3546 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_824723.1 4388666 D 227882 CDS NP_824724.1 29830090 1214573 4389314..4390057 1 NC_003155.4 ketoreductase 4390057 1214573 SAV_3547 Streptomyces avermitilis MA-4680 ketoreductase NP_824724.1 4389314 D 227882 CDS NP_824725.1 29830091 1214574 complement(4390175..4390561) 1 NC_003155.4 MerR family transcriptional regulator 4390561 1214574 SAV_3548 Streptomyces avermitilis MA-4680 MerR family transcriptional regulator NP_824725.1 4390175 R 227882 CDS NP_824726.1 29830092 1210763 complement(4390621..4394151) 1 NC_003155.4 transcriptional-repair coupling factor 4394151 mfd 1210763 mfd Streptomyces avermitilis MA-4680 transcriptional-repair coupling factor NP_824726.1 4390621 R 227882 CDS NP_824727.1 29830093 1214575 complement(4394409..4396976) 1 NC_003155.4 ABC transporter permease 4396976 1214575 SAV_3550 Streptomyces avermitilis MA-4680 ABC transporter permease NP_824727.1 4394409 R 227882 CDS NP_824728.1 29830094 1214576 complement(4396973..4397761) 1 NC_003155.4 ABC transporter ATP-binding protein 4397761 1214576 SAV_3551 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_824728.1 4396973 R 227882 CDS NP_824729.1 29830095 1214577 4398149..4399708 1 NC_003155.4 PF07690: Major Facilitator Superfamily; integral membrane transport protein 4399708 1214577 SAV_3552 Streptomyces avermitilis MA-4680 integral membrane transport protein NP_824729.1 4398149 D 227882 CDS NP_824730.1 29830096 1214578 4400034..4400513 1 NC_003155.4 PF04341: Protein of unknown function, DUF485; hypothetical protein 4400513 1214578 SAV_3553 Streptomyces avermitilis MA-4680 hypothetical protein NP_824730.1 4400034 D 227882 CDS NP_824731.1 29830097 1214579 4400510..4402156 1 NC_003155.4 PF00474: Sodium:solute symporter family; transmembrane transport protein 4402156 1214579 SAV_3554 Streptomyces avermitilis MA-4680 transmembrane transport protein NP_824731.1 4400510 D 227882 CDS NP_824732.1 29830098 1214580 complement(4402232..4403131) 1 NC_003155.4 cellulose-binding protein 4403131 1214580 SAV_3555 Streptomyces avermitilis MA-4680 cellulose-binding protein NP_824732.1 4402232 R 227882 CDS NP_824733.1 29830099 1214581 complement(4403425..4406136) 1 NC_003155.4 PF01391: Collagen triple helix repeat (20 copies); hypothetical protein 4406136 1214581 SAV_3556 Streptomyces avermitilis MA-4680 hypothetical protein NP_824733.1 4403425 R 227882 CDS NP_824734.1 29830100 1214582 complement(4406510..4407496) 1 NC_003155.4 hypothetical protein 4407496 1214582 SAV_3557 Streptomyces avermitilis MA-4680 hypothetical protein NP_824734.1 4406510 R 227882 CDS NP_824735.1 29830101 1214583 4407750..4408250 1 NC_003155.4 hypothetical protein 4408250 1214583 SAV_3558 Streptomyces avermitilis MA-4680 hypothetical protein NP_824735.1 4407750 D 227882 CDS NP_824736.1 29830102 1214584 4408326..4408820 1 NC_003155.4 hypothetical protein 4408820 1214584 SAV_3559 Streptomyces avermitilis MA-4680 hypothetical protein NP_824736.1 4408326 D 227882 CDS NP_824737.1 29830103 1214585 complement(4408838..4410157) 1 NC_003155.4 two-component system sensor kinase 4410157 1214585 SAV_3560 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_824737.1 4408838 R 227882 CDS NP_824738.1 29830104 1210765 4410718..4412166 1 NC_003155.4 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 4412166 glmU 1210765 glmU Streptomyces avermitilis MA-4680 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase NP_824738.1 4410718 D 227882 CDS NP_824739.1 29830105 1210766 4412314..4413288 1 NC_003155.4 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 4413288 prsA1 1210766 prsA1 Streptomyces avermitilis MA-4680 ribose-phosphate pyrophosphokinase NP_824739.1 4412314 D 227882 CDS NP_824740.1 29830106 1210767 4413467..4414060 1 NC_003155.4 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25/general stress protein Ctc 4414060 rplY 1210767 rplY Streptomyces avermitilis MA-4680 50S ribosomal protein L25/general stress protein Ctc NP_824740.1 4413467 D 227882 CDS NP_824741.1 29830107 1210768 4414139..4414750 1 NC_003155.4 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 4414750 pth 1210768 pth Streptomyces avermitilis MA-4680 peptidyl-tRNA hydrolase NP_824741.1 4414139 D 227882 CDS NP_824742.1 29830108 1214586 4414835..4415347 1 NC_003155.4 hypothetical protein 4415347 1214586 SAV_3565 Streptomyces avermitilis MA-4680 hypothetical protein NP_824742.1 4414835 D 227882 CDS NP_824743.1 29830109 1210769 complement(4415436..4418168) 1 NC_003155.4 phosphoenolpyruvate carboxylase 4418168 ppc 1210769 ppc Streptomyces avermitilis MA-4680 phosphoenolpyruvate carboxylase NP_824743.1 4415436 R 227882 CDS NP_824744.1 29830110 1210770 4418467..4419477 1 NC_003155.4 fatty acid desaturase 4419477 desC 1210770 desC Streptomyces avermitilis MA-4680 fatty acid desaturase NP_824744.1 4418467 D 227882 CDS NP_824745.1 29830111 1214587 4419474..4420151 1 NC_003155.4 TetR family transcriptional regulator 4420151 1214587 SAV_3568 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_824745.1 4419474 D 227882 CDS NP_824746.1 29830112 1214588 complement(4420266..4420634) 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein 4420634 1214588 SAV_3569 Streptomyces avermitilis MA-4680 hypothetical protein NP_824746.1 4420266 R 227882 CDS NP_824747.1 29830113 1214589 complement(4420634..4421443) 1 NC_003155.4 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 4421443 1214589 SAV_3570 Streptomyces avermitilis MA-4680 trans-aconitate 2-methyltransferase NP_824747.1 4420634 R 227882 CDS NP_824748.1 29830114 1214590 4421595..4422092 1 NC_003155.4 MarR family transcriptional regulator 4422092 1214590 SAV_3571 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_824748.1 4421595 D 227882 CDS NP_824749.1 29830115 1214591 complement(4422051..4422830) 1 NC_003155.4 two-component system response regulator 4422830 1214591 SAV_3572 Streptomyces avermitilis MA-4680 two-component system response regulator NP_824749.1 4422051 R 227882 CDS NP_824750.1 29830116 1214592 4423042..4423533 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 4423533 1214592 SAV_3573 Streptomyces avermitilis MA-4680 acetyltransferase NP_824750.1 4423042 D 227882 CDS NP_824751.1 29830117 1210771 complement(4423526..4424671) 1 NC_003155.4 galactokinase 4424671 galK 1210771 galK Streptomyces avermitilis MA-4680 galactokinase NP_824751.1 4423526 R 227882 CDS NP_824752.1 29830118 1210772 complement(4424675..4425634) 1 NC_003155.4 UDP-glucose 4-epimerase 4425634 galE1 1210772 galE1 Streptomyces avermitilis MA-4680 UDP-glucose 4-epimerase NP_824752.1 4424675 R 227882 CDS NP_824753.1 29830119 1210773 complement(4425631..4426716) 1 NC_003155.4 galactose-1-phosphate uridylyltransferase 4426716 galT 1210773 galT Streptomyces avermitilis MA-4680 galactose-1-phosphate uridylyltransferase NP_824753.1 4425631 R 227882 CDS NP_824754.1 29830120 1214593 4426894..4428603 1 NC_003155.4 Na+/galactose cotransporter 4428603 1214593 SAV_3577 Streptomyces avermitilis MA-4680 Na+/galactose cotransporter NP_824754.1 4426894 D 227882 CDS NP_824755.1 29830121 1214594 4428625..4428912 1 NC_003155.4 hypothetical protein 4428912 1214594 SAV_3578 Streptomyces avermitilis MA-4680 hypothetical protein NP_824755.1 4428625 D 227882 CDS NP_824756.1 29830122 1214595 4429108..4429905 1 NC_003155.4 PF07398: Protein of unknown function (DUF1503); hypothetical protein 4429905 1214595 SAV_3579 Streptomyces avermitilis MA-4680 hypothetical protein NP_824756.1 4429108 D 227882 CDS NP_824757.1 29830123 1214596 4430349..4430834 1 NC_003155.4 hypothetical protein 4430834 1214596 SAV_3580 Streptomyces avermitilis MA-4680 hypothetical protein NP_824757.1 4430349 D 227882 CDS NP_824758.1 29830124 1214597 complement(4430980..4431705) 1 NC_003155.4 two-component system response regulator 4431705 1214597 SAV_3581 Streptomyces avermitilis MA-4680 two-component system response regulator NP_824758.1 4430980 R 227882 CDS NP_824759.1 29830125 1214598 complement(4431956..4433449) 1 NC_003155.4 PF01011: PQQ enzyme repeat; hypothetical protein 4433449 1214598 SAV_3582 Streptomyces avermitilis MA-4680 hypothetical protein NP_824759.1 4431956 R 227882 CDS NP_824760.1 29830126 1214599 complement(4433916..4435787) 1 NC_003155.4 hypothetical protein 4435787 1214599 SAV_3583 Streptomyces avermitilis MA-4680 hypothetical protein NP_824760.1 4433916 R 227882 CDS NP_824761.1 29830127 1214600 complement(4436011..4437816) 1 NC_003155.4 ABC transporter ATP-binding protein 4437816 1214600 SAV_3584 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_824761.1 4436011 R 227882 CDS NP_824762.1 29830128 1214601 complement(4437912..4439246) 1 NC_003155.4 PF01757: Acyltransferase family; hypothetical protein 4439246 1214601 SAV_3585 Streptomyces avermitilis MA-4680 hypothetical protein NP_824762.1 4437912 R 227882 CDS NP_824763.1 29830129 1210774 complement(4439401..4440294) 1 NC_003155.4 catalyzes the phosphorylation of 4-diphosphocytidyl-2-C-methyl-D-erythritol in the nonmevalonate pathway of isoprenoid biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 4440294 cmek 1210774 cmek Streptomyces avermitilis MA-4680 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase NP_824763.1 4439401 R 227882 CDS NP_824764.1 29830130 1210775 complement(4440310..4441197) 1 NC_003155.4 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 4441197 ksgA 1210775 ksgA Streptomyces avermitilis MA-4680 dimethyladenosine transferase NP_824764.1 4440310 R 227882 CDS NP_824765.1 29830131 1214602 complement(4441559..4443094) 1 NC_003155.4 PF03990: Domain of unknown function (DUF348); hypothetical protein 4443094 1214602 SAV_3588 Streptomyces avermitilis MA-4680 hypothetical protein NP_824765.1 4441559 R 227882 CDS NP_824766.1 29830132 1214603 complement(4443175..4444062) 1 NC_003155.4 deoxyribonuclease 4444062 1214603 SAV_3589 Streptomyces avermitilis MA-4680 deoxyribonuclease NP_824766.1 4443175 R 227882 CDS NP_824767.1 29830133 1214604 complement(4444182..4444598) 1 NC_003155.4 hypothetical protein 4444598 1214604 SAV_3590 Streptomyces avermitilis MA-4680 hypothetical protein NP_824767.1 4444182 R 227882 CDS NP_824768.1 29830134 1214605 complement(4444966..4445832) 1 NC_003155.4 tetrapyrrole methylase 4445832 1214605 SAV_3591 Streptomyces avermitilis MA-4680 tetrapyrrole methylase NP_824768.1 4444966 R 227882 CDS NP_824769.1 29830135 1214606 4445895..4447634 1 NC_003155.4 PF02366: Dolichyl-phosphate-mannose-protein mannosyltransferase; integral membrane protein 4447634 1214606 SAV_3592 Streptomyces avermitilis MA-4680 integral membrane protein NP_824769.1 4445895 D 227882 CDS NP_824770.1 29830136 1214607 4449642..4450097 1 NC_003155.4 PF00383: Cytidine and deoxycytidylate deaminase zinc-binding region; hypothetical protein 4450097 1214607 SAV_3593 Streptomyces avermitilis MA-4680 hypothetical protein NP_824770.1 4449642 D 227882 CDS NP_824771.1 29830137 1214608 4450251..4451030 1 NC_003155.4 hypothetical protein 4451030 1214608 SAV_3594 Streptomyces avermitilis MA-4680 hypothetical protein NP_824771.1 4450251 D 227882 CDS NP_824772.1 29830138 1214609 4451252..4451962 1 NC_003155.4 hypothetical protein 4451962 1214609 SAV_3595 Streptomyces avermitilis MA-4680 hypothetical protein NP_824772.1 4451252 D 227882 CDS NP_824773.1 29830139 1214610 complement(4451880..4452179) 1 NC_003155.4 hypothetical protein 4452179 1214610 SAV_3596 Streptomyces avermitilis MA-4680 hypothetical protein NP_824773.1 4451880 R 227882 CDS NP_824774.1 29830140 1214611 complement(4452893..4453570) 1 NC_003155.4 PF02683: Cytochrome C biogenesis protein transmembrane region; hypothetical protein 4453570 1214611 SAV_3597 Streptomyces avermitilis MA-4680 hypothetical protein NP_824774.1 4452893 R 227882 CDS NP_824775.1 29830141 1214612 4454104..4454766 1 NC_003155.4 hypothetical protein 4454766 1214612 SAV_3598 Streptomyces avermitilis MA-4680 hypothetical protein NP_824775.1 4454104 D 227882 CDS NP_824776.1 29830142 1214613 4454905..4456275 1 NC_003155.4 peroxidase 4456275 1214613 SAV_3599 Streptomyces avermitilis MA-4680 peroxidase NP_824776.1 4454905 D 227882 CDS NP_824777.1 29830143 1214614 4456330..4457460 1 NC_003155.4 hypothetical protein 4457460 1214614 SAV_3600 Streptomyces avermitilis MA-4680 hypothetical protein NP_824777.1 4456330 D 227882 CDS NP_824778.1 29830144 1210776 4457596..4458960 1 NC_003155.4 PF00282: Pyridoxal-dependent decarboxylase conserved domain; glutamate decarboxylase 4458960 gadB1 1210776 gadB1 Streptomyces avermitilis MA-4680 glutamate decarboxylase NP_824778.1 4457596 D 227882 CDS NP_824779.1 29830145 1214615 complement(4459065..4460207) 1 NC_003155.4 hypothetical protein 4460207 1214615 SAV_3602 Streptomyces avermitilis MA-4680 hypothetical protein NP_824779.1 4459065 R 227882 CDS NP_824780.1 29830146 1210777 4460304..4461935 1 NC_003155.4 PF05223: NTF2-like N-terminal transpeptidase domain; penicillin-binding protein 4461935 pbp3 1210777 pbp3 Streptomyces avermitilis MA-4680 penicillin-binding protein NP_824780.1 4460304 D 227882 CDS NP_824781.1 29830147 1210778 4462029..4463702 1 NC_003155.4 PF05223: NTF2-like N-terminal transpeptidase domain; penicillin-binding protein 4463702 pbp4 1210778 pbp4 Streptomyces avermitilis MA-4680 penicillin-binding protein NP_824781.1 4462029 D 227882 CDS NP_824782.1 29830148 1214616 complement(4463747..4464088) 1 NC_003155.4 PF04686: Streptomyces sporulation and cell division protein, SsgA; cell division protein, regulatory protein 4464088 ssgA6 1214616 ssgA6 Streptomyces avermitilis MA-4680 cell division protein, regulatory protein NP_824782.1 4463747 R 227882 CDS NP_824783.1 29830149 1214617 4464253..4465308 1 NC_003155.4 cobalt ABC transporter permease component 4465308 cbiM 1214617 cbiM Streptomyces avermitilis MA-4680 cobalt ABC transporter permease component NP_824783.1 4464253 D 227882 CDS NP_824784.1 29830150 1214618 4465310..4466071 1 NC_003155.4 cobalt ABC transporter permease component 4466071 cbiQ 1214618 cbiQ Streptomyces avermitilis MA-4680 cobalt ABC transporter permease component NP_824784.1 4465310 D 227882 CDS NP_824785.1 29830151 1214619 4466086..4466874 1 NC_003155.4 ABC transporter ATP-binding protein 4466874 1214619 SAV_3608 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_824785.1 4466086 D 227882 CDS NP_824786.1 29830152 1214620 4466871..4467332 1 NC_003155.4 MarR family transcriptional regulator 4467332 1214620 SAV_3609 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_824786.1 4466871 D 227882 CDS NP_824787.1 29830153 1210779 4467529..4467933 1 NC_003155.4 organic hydroperoxide resistance protein 4467933 ohrB1 1210779 ohrB1 Streptomyces avermitilis MA-4680 organic hydroperoxide resistance protein NP_824787.1 4467529 D 227882 CDS NP_824788.1 29830154 1214621 4467965..4469167 1 NC_003155.4 esterase 4469167 1214621 SAV_3611 Streptomyces avermitilis MA-4680 esterase NP_824788.1 4467965 D 227882 CDS NP_824789.1 29830155 1214622 complement(4469212..4469487) 1 NC_003155.4 hypothetical protein 4469487 1214622 SAV_3612 Streptomyces avermitilis MA-4680 hypothetical protein NP_824789.1 4469212 R 227882 CDS NP_824790.1 29830156 1214623 complement(4469586..4470431) 1 NC_003155.4 PF00892: Integral membrane protein DUF6; integral membrane protein 4470431 1214623 SAV_3613 Streptomyces avermitilis MA-4680 integral membrane protein NP_824790.1 4469586 R 227882 CDS NP_824791.1 29830157 1214624 complement(4470428..4470979) 1 NC_003155.4 PF04073: YbaK / prolyl-tRNA synthetases associated domain; hypothetical protein 4470979 1214624 SAV_3614 Streptomyces avermitilis MA-4680 hypothetical protein NP_824791.1 4470428 R 227882 CDS NP_824792.1 29830158 1214625 complement(4471011..4471199) 1 NC_003155.4 PF04149: Domain of unknown function (DUF397); hypothetical protein 4471199 1214625 SAV_3615 Streptomyces avermitilis MA-4680 hypothetical protein NP_824792.1 4471011 R 227882 CDS NP_824793.1 29830159 1214626 complement(4471196..4471843) 1 NC_003155.4 DNA-binding protein 4471843 1214626 SAV_3617 Streptomyces avermitilis MA-4680 DNA-binding protein NP_824793.1 4471196 R 227882 CDS NP_824794.1 29830160 1214627 4471682..4472491 1 NC_003155.4 hypothetical protein 4472491 1214627 SAV_3616 Streptomyces avermitilis MA-4680 hypothetical protein NP_824794.1 4471682 D 227882 CDS NP_824795.1 29830161 1214628 complement(4472574..4474799) 1 NC_003155.4 PF03176: MMPL family; transmembrane transport protein 4474799 1214628 SAV_3618 Streptomyces avermitilis MA-4680 transmembrane transport protein NP_824795.1 4472574 R 227882 CDS NP_824796.1 29830162 1214629 complement(4474929..4475519) 1 NC_003155.4 TetR family transcriptional regulator 4475519 1214629 SAV_3619 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_824796.1 4474929 R 227882 CDS NP_824797.1 29830163 1214630 4475706..4479011 1 NC_003155.4 PF03572: Peptidase family S41; protease 4479011 1214630 SAV_3620 Streptomyces avermitilis MA-4680 protease NP_824797.1 4475706 D 227882 CDS NP_824798.1 29830164 1214631 complement(4479074..4479247) 1 NC_003155.4 hypothetical protein 4479247 1214631 SAV_3621 Streptomyces avermitilis MA-4680 hypothetical protein NP_824798.1 4479074 R 227882 CDS NP_824799.1 29830165 1214632 complement(4479277..4479522) 1 NC_003155.4 hypothetical protein 4479522 1214632 SAV_3622 Streptomyces avermitilis MA-4680 hypothetical protein NP_824799.1 4479277 R 227882 CDS NP_824800.1 29830166 1214633 complement(4479600..4480484) 1 NC_003155.4 PF00106: short chain dehydrogenase; short chain dehydrogenase 4480484 1214633 SAV_3623 Streptomyces avermitilis MA-4680 short chain dehydrogenase NP_824800.1 4479600 R 227882 CDS NP_824801.1 29830167 1214634 complement(4480481..4481404) 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 4481404 1214634 SAV_3624 Streptomyces avermitilis MA-4680 hydrolase NP_824801.1 4480481 R 227882 CDS NP_824802.1 29830168 1214635 complement(4481401..4482963) 1 NC_003155.4 PF00743: Flavin-binding monooxygenase-like; monooxygenase 4482963 1214635 SAV_3625 Streptomyces avermitilis MA-4680 monooxygenase NP_824802.1 4481401 R 227882 CDS NP_824803.1 29830169 1214636 4483072..4483740 1 NC_003155.4 MerR family transcriptional regulator 4483740 1214636 SAV_3626 Streptomyces avermitilis MA-4680 MerR family transcriptional regulator NP_824803.1 4483072 D 227882 CDS NP_824804.1 29830170 1210780 complement(4483778..4484641) 1 NC_003155.4 exodeoxyribonuclease 4484641 exoA 1210780 exoA Streptomyces avermitilis MA-4680 exodeoxyribonuclease NP_824804.1 4483778 R 227882 CDS NP_824805.1 29830171 1214637 4484640..4485131 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 4485131 1214637 SAV_3627 Streptomyces avermitilis MA-4680 acetyltransferase NP_824805.1 4484640 D 227882 CDS NP_824806.1 29830172 1214638 complement(4485157..4485609) 1 NC_003155.4 protein 4485609 1214638 SAV_3629 Streptomyces avermitilis MA-4680 protein NP_824806.1 4485157 R 227882 CDS NP_824807.1 29830173 1214639 complement(4485804..4486463) 1 NC_003155.4 two-component system response regulator 4486463 1214639 SAV_3630 Streptomyces avermitilis MA-4680 two-component system response regulator NP_824807.1 4485804 R 227882 CDS NP_824808.1 29830174 1214640 complement(4486436..4487725) 1 NC_003155.4 two-component system sensor kinase 4487725 1214640 SAV_3631 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_824808.1 4486436 R 227882 CDS NP_824809.1 29830175 1214641 4488112..4489959 1 NC_003155.4 AfsR homolog, PF03704: Bacterial transcriptional activator domain; regulatory protein 4489959 1214641 SAV_3632 Streptomyces avermitilis MA-4680 regulatory protein NP_824809.1 4488112 D 227882 CDS NP_824810.1 29830176 1214642 4490080..4490592 1 NC_003155.4 PF00597: DedA family; hypothetical protein 4490592 1214642 SAV_3633 Streptomyces avermitilis MA-4680 hypothetical protein NP_824810.1 4490080 D 227882 CDS NP_824811.1 29830177 1214643 4490744..4491490 1 NC_003155.4 ABC transporter ATP-binding protein 4491490 1214643 SAV_3634 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_824811.1 4490744 D 227882 CDS NP_824812.1 29830178 1214644 4491484..4493940 1 NC_003155.4 ABC transporter permease 4493940 1214644 SAV_3635 Streptomyces avermitilis MA-4680 ABC transporter permease NP_824812.1 4491484 D 227882 CDS NP_824813.1 29830179 1214645 complement(4494250..4495185) 1 NC_003155.4 nrps2 gene cluster; SyrP-like protein 4495185 1214645 SAV_3636 Streptomyces avermitilis MA-4680 SyrP-like protein NP_824813.1 4494250 R 227882 CDS NP_824814.1 29830180 1210781 complement(4495182..4495976) 1 NC_003155.4 nrps2 gene cluster, PF01648: 4'-phosphopantetheinyl transferase superfamily; phosphopantetheinyl transferase 4495976 pptA4 1210781 pptA4 Streptomyces avermitilis MA-4680 phosphopantetheinyl transferase NP_824814.1 4495182 R 227882 CDS NP_824815.1 29830181 1214646 complement(4496016..4496951) 1 NC_003155.4 nrps2 gene cluster; SyrP-like protein 4496951 1214646 SAV_3638 Streptomyces avermitilis MA-4680 SyrP-like protein NP_824815.1 4496016 R 227882 CDS NP_824816.1 29830182 1214647 complement(4496955..4497704) 1 NC_003155.4 nrps2 gene cluster; thioesterase 4497704 1214647 SAV_3639 Streptomyces avermitilis MA-4680 thioesterase NP_824816.1 4496955 R 227882 CDS NP_824817.1 29830183 1214648 complement(4497725..4499077) 1 NC_003155.4 nrps2 gene cluster, PF07690: Major Facilitator Superfamily; multidrug resistance protein 4499077 1214648 SAV_3640 Streptomyces avermitilis MA-4680 multidrug resistance protein NP_824817.1 4497725 R 227882 CDS NP_824818.1 29830184 1214649 complement(4499074..4499997) 1 NC_003155.4 nrps2 gene cluster; ornithine carbamoyltransferase 4499997 1214649 SAV_3641 Streptomyces avermitilis MA-4680 ornithine carbamoyltransferase NP_824818.1 4499074 R 227882 CDS NP_824819.1 29830185 1214650 complement(4500084..4511144) 1 NC_003155.4 nrps2 gene cluster; non-ribosomal peptide synthetase 4511144 nrps2-1 1214650 nrps2-1 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_824819.1 4500084 R 227882 CDS NP_824820.1 29830186 1214651 complement(4511156..4516285) 1 NC_003155.4 nrps2 gene cluster, NRPS involved in dihydroxy-benzoyl-glycine biosynthesis; non-ribosomal peptide synthetase 4516285 nrps2-2 1214651 nrps2-2 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_824820.1 4511156 R 227882 CDS NP_824821.1 29830187 1214652 complement(4516329..4516595) 1 NC_003155.4 nrps2 gene cluster; MbtH-like protein 4516595 1214652 SAV_3644 Streptomyces avermitilis MA-4680 MbtH-like protein NP_824821.1 4516329 R 227882 CDS NP_824822.1 29830188 1210782 complement(4516629..4517633) 1 NC_003155.4 nrps2 gene cluster; ornithine cyclodeaminase 4517633 arcB2 1210782 arcB2 Streptomyces avermitilis MA-4680 ornithine cyclodeaminase NP_824822.1 4516629 R 227882 CDS NP_824823.1 29830189 1214653 complement(4517725..4518525) 1 NC_003155.4 nrps2 gene cluster; methyltransferase 4518525 1214653 SAV_3646 Streptomyces avermitilis MA-4680 methyltransferase NP_824823.1 4517725 R 227882 CDS NP_824824.1 29830190 1214654 complement(4518522..4519862) 1 NC_003155.4 nrps2 gene cluster; non-ribosomal peptide synthetase 4519862 nrps2-3 1214654 nrps2-3 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_824824.1 4518522 R 227882 CDS NP_824825.1 29830191 1210783 complement(4519876..4520859) 1 NC_003155.4 nrps2 gene cluster; cysteine synthase 4520859 cysK2 1210783 cysK2 Streptomyces avermitilis MA-4680 cysteine synthase NP_824825.1 4519876 R 227882 CDS NP_824826.1 29830192 1214655 complement(4521113..4521379) 1 NC_003155.4 nrps2 gene cluster; peptide carrier protein 4521379 1214655 SAV_3649 Streptomyces avermitilis MA-4680 peptide carrier protein NP_824826.1 4521113 R 227882 CDS NP_824827.1 29830193 1210784 complement(4521379..4523208) 1 NC_003155.4 nrps2 gene cluster, PF02770: Acyl-CoA dehydrogenase, middle domain; acyl-CoA dehydrogenase 4523208 fadE25 1210784 fadE25 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_824827.1 4521379 R 227882 CDS NP_824828.1 29830194 1214656 complement(4523205..4526990) 1 NC_003155.4 nrps2 gene cluster; non-ribosomal peptide synthetase/acyl-CoA dehydrogenase fusion protein 4526990 nrps2-4 1214656 nrps2-4 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase/acyl-CoA dehydrogenase fusion protein NP_824828.1 4523205 R 227882 CDS NP_824829.1 29830195 1214657 complement(4527167..4527892) 1 NC_003155.4 isomerase 4527892 1214657 SAV_3652 Streptomyces avermitilis MA-4680 isomerase NP_824829.1 4527167 R 227882 CDS NP_824830.1 29830196 1210785 complement(4527901..4528842) 1 NC_003155.4 pks8 gene cluster, PF00106: short chain dehydrogenase; 3-oxoacyl-ACP reductase 4528842 fabG4 1210785 fabG4 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP reductase NP_824830.1 4527901 R 227882 CDS NP_824831.1 29830197 1210786 complement(4528854..4529351) 1 NC_003155.4 pks8 gene cluster; 3-hydroxyacyl-ACP dehydratase 4529351 fabA 1210786 fabA Streptomyces avermitilis MA-4680 3-hydroxyacyl-ACP dehydratase NP_824831.1 4528854 R 227882 CDS NP_824832.1 29830198 1214658 complement(4529354..4529818) 1 NC_003155.4 pks8 gene cluster; dehydratase 4529818 1214658 SAV_3655 Streptomyces avermitilis MA-4680 dehydratase NP_824832.1 4529354 R 227882 CDS NP_824833.1 29830199 1214659 complement(4529815..4530078) 1 NC_003155.4 pks8 gene cluster; ACP 4530078 pks8-1 1214659 pks8-1 Streptomyces avermitilis MA-4680 ACP NP_824833.1 4529815 R 227882 CDS NP_824834.1 29830200 1214660 complement(4530195..4531313) 1 NC_003155.4 pks8 gene cluster; 3-oxoacyl-ACP synthase I 4531313 pks8-2 1214660 pks8-2 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP synthase I NP_824834.1 4530195 R 227882 CDS NP_824835.1 29830201 1214661 complement(4531440..4532255) 1 NC_003155.4 pks8 gene cluster; 3-oxoacyl-ACP reductase 4532255 pks8-3 1214661 pks8-3 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP reductase NP_824835.1 4531440 R 227882 CDS NP_824836.1 29830202 1214662 complement(4532239..4533351) 1 NC_003155.4 pks8 gene cluster; 3-oxoacyl-ACP synthase II 4533351 pks8-4 1214662 pks8-4 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP synthase II NP_824836.1 4532239 R 227882 CDS NP_824837.1 29830203 1214663 complement(4533377..4534696) 1 NC_003155.4 pks8 gene cluster; 3-oxoacyl-ACP synthase I 4534696 pks8-5 1214663 pks8-5 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP synthase I NP_824837.1 4533377 R 227882 CDS NP_824838.1 29830204 1214664 complement(4534714..4535697) 1 NC_003155.4 pks8 gene cluster; hypothetical protein 4535697 1214664 SAV_3661 Streptomyces avermitilis MA-4680 hypothetical protein NP_824838.1 4534714 R 227882 CDS NP_824839.1 29830205 1214665 complement(4535694..4536419) 1 NC_003155.4 pks8 gene cluster, PF00561: alpha/beta hydrolase fold; hydrolase 4536419 1214665 SAV_3662 Streptomyces avermitilis MA-4680 hydrolase NP_824839.1 4535694 R 227882 CDS NP_824840.1 29830206 1214666 complement(4536612..4537697) 1 NC_003155.4 pks8 gene cluster; 3-oxoacyl-ACP synthase I 4537697 pks8-6 1214666 pks8-6 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP synthase I NP_824840.1 4536612 R 227882 CDS NP_824841.1 29830207 1214667 complement(4537694..4538857) 1 NC_003155.4 pks8 gene cluster; 3-oxoacyl-ACP synthase II 4538857 pks8-7 1214667 pks8-7 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP synthase II NP_824841.1 4537694 R 227882 CDS NP_824842.1 29830208 1214668 complement(4538875..4540161) 1 NC_003155.4 pks8 gene cluster; 3-oxoacyl-ACP synthase I 4540161 pks8-8 1214668 pks8-8 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP synthase I NP_824842.1 4538875 R 227882 CDS NP_824843.1 29830209 1214669 complement(4540196..4540450) 1 NC_003155.4 pks8 gene cluster; ACP 4540450 pks8-9 1214669 pks8-9 Streptomyces avermitilis MA-4680 ACP NP_824843.1 4540196 R 227882 CDS NP_824844.1 29830210 1214670 complement(4540555..4541568) 1 NC_003155.4 LuxR-family transcriptional regulatory protein; erythropoiesis-stimulating protein 4541568 1214670 SAV_3667 Streptomyces avermitilis MA-4680 erythropoiesis-stimulating protein NP_824844.1 4540555 R 227882 CDS NP_824845.1 29830211 1214671 complement(4542661..4544010) 1 NC_003155.4 hypothetical protein 4544010 1214671 SAV_3668 Streptomyces avermitilis MA-4680 hypothetical protein NP_824845.1 4542661 R 227882 CDS NP_824846.1 29830212 1210788 complement(4544195..4544665) 1 NC_003155.4 ribosomal-protein-alanine N-acetyltransferase 4544665 rimJ 1210788 rimJ Streptomyces avermitilis MA-4680 ribosomal-protein-alanine N-acetyltransferase NP_824846.1 4544195 R 227882 CDS NP_824847.1 29830213 1210789 complement(4544851..4545390) 1 NC_003155.4 probable molybdenum cofactor biosynthesis protein; molybdopterin biosynthesis protein 4545390 moaB 1210789 moaB Streptomyces avermitilis MA-4680 molybdopterin biosynthesis protein NP_824847.1 4544851 R 227882 CDS NP_824848.1 29830214 1210790 complement(4545387..4545899) 1 NC_003155.4 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 4545899 moaC 1210790 moaC Streptomyces avermitilis MA-4680 molybdenum cofactor biosynthesis protein MoaC NP_824848.1 4545387 R 227882 CDS NP_824849.1 29830215 1210791 complement(4545984..4547258) 1 NC_003155.4 molybdopterin biosynthesis protein 4547258 moaA1 1210791 moaA1 Streptomyces avermitilis MA-4680 molybdopterin biosynthesis protein NP_824849.1 4545984 R 227882 CDS NP_824850.1 29830216 1210792 complement(4547311..4548213) 1 NC_003155.4 UTP:glucose-1-phosphate uridylyltransferase 4548213 gtaB 1210792 gtaB Streptomyces avermitilis MA-4680 UTP:glucose-1-phosphate uridylyltransferase NP_824850.1 4547311 R 227882 CDS NP_824851.1 29830217 1214672 4548308..4548931 1 NC_003155.4 ligase 4548931 1214672 SAV_3674 Streptomyces avermitilis MA-4680 ligase NP_824851.1 4548308 D 227882 CDS NP_824852.1 29830218 1214673 complement(4549001..4551811) 1 NC_003155.4 PF01804: Penicillin amidase; penicillin acylase 4551811 pacB1 1214673 pacB1 Streptomyces avermitilis MA-4680 penicillin acylase NP_824852.1 4549001 R 227882 CDS NP_824853.1 29830219 1214674 4552050..4553621 1 NC_003155.4 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter 4553621 1214674 SAV_3676 Streptomyces avermitilis MA-4680 potassium/proton antiporter NP_824853.1 4552050 D 227882 CDS NP_824854.1 29830220 1214675 4553938..4555236 1 NC_003155.4 PF07690: Major Facilitator Superfamily; ABC transporter permease 4555236 1214675 SAV_3677 Streptomyces avermitilis MA-4680 ABC transporter permease NP_824854.1 4553938 D 227882 CDS NP_824855.1 29830221 1214676 4555305..4555646 1 NC_003155.4 hypothetical protein 4555646 1214676 SAV_3678 Streptomyces avermitilis MA-4680 hypothetical protein NP_824855.1 4555305 D 227882 CDS NP_824856.1 29830222 1210793 4555722..4556555 1 NC_003155.4 Catalyzes the reversible phosphorolysis of 5'-deoxy-5'- methylthioadenosine (MTA) to adenine and 5-methylthio-D-ribose-1- phosphate; 5'-methylthioadenosine phosphorylase 4556555 mtaP 1210793 mtaP Streptomyces avermitilis MA-4680 5'-methylthioadenosine phosphorylase NP_824856.1 4555722 D 227882 CDS NP_824857.1 29830223 1214677 4556821..4557315 1 NC_003155.4 PF06981: Flp pilus assembly protein CpaB; hypothetical protein 4557315 1214677 SAV_3680 Streptomyces avermitilis MA-4680 hypothetical protein NP_824857.1 4556821 D 227882 CDS NP_824858.1 29830224 1210794 4557442..4557918 1 NC_003155.4 mechanosensitive channel 4557918 mscL 1210794 mscL Streptomyces avermitilis MA-4680 mechanosensitive channel NP_824858.1 4557442 D 227882 CDS NP_824859.1 29830225 1214678 complement(4557974..4558150) 1 NC_003155.4 hypothetical protein 4558150 1214678 SAV_3682 Streptomyces avermitilis MA-4680 hypothetical protein NP_824859.1 4557974 R 227882 CDS NP_824860.1 29830226 1214679 4558240..4559496 1 NC_003155.4 PF06772: Bacterial low temperature requirement A protein (LtrA); hypothetical protein 4559496 1214679 SAV_3683 Streptomyces avermitilis MA-4680 hypothetical protein NP_824860.1 4558240 D 227882 CDS NP_824861.1 29830227 1214680 4559528..4560556 1 NC_003155.4 PF03576: peptidase family T4; hypothetical protein 4560556 1214680 SAV_3684 Streptomyces avermitilis MA-4680 hypothetical protein NP_824861.1 4559528 D 227882 CDS NP_824862.1 29830228 1214681 4560793..4562019 1 NC_003155.4 PF03734: ErfK/YbiS/YcfS/YnhG; lipoprotein 4562019 1214681 SAV_3685 Streptomyces avermitilis MA-4680 lipoprotein NP_824862.1 4560793 D 227882 CDS NP_824863.1 29830229 1214682 4562200..4562949 1 NC_003155.4 hypothetical protein 4562949 1214682 SAV_3686 Streptomyces avermitilis MA-4680 hypothetical protein NP_824863.1 4562200 D 227882 CDS NP_824864.1 29830230 1214683 complement(4563070..4563360) 1 NC_003155.4 hypothetical protein 4563360 1214683 SAV_3687 Streptomyces avermitilis MA-4680 hypothetical protein NP_824864.1 4563070 R 227882 CDS NP_824865.1 29830231 1210795 complement(4563555..4565669) 1 NC_003155.4 fructose-specific permease 4565669 fruA 1210795 fruA Streptomyces avermitilis MA-4680 fructose-specific permease NP_824865.1 4563555 R 227882 CDS NP_824866.1 29830232 1210796 complement(4565839..4566792) 1 NC_003155.4 1-phosphofructokinase 4566792 fruB 1210796 fruB Streptomyces avermitilis MA-4680 1-phosphofructokinase NP_824866.1 4565839 R 227882 CDS NP_824867.1 29830233 1214684 complement(4566789..4567550) 1 NC_003155.4 DeoR family transcriptional regulator 4567550 1214684 SAV_3690 Streptomyces avermitilis MA-4680 DeoR family transcriptional regulator NP_824867.1 4566789 R 227882 CDS NP_824868.1 29830234 1214685 complement(4567874..4569388) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 4569388 1214685 SAV_3691 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_824868.1 4567874 R 227882 CDS NP_824869.1 29830235 1214686 4569451..4570443 1 NC_003155.4 DeoR family transcriptional regulator 4570443 1214686 SAV_3692 Streptomyces avermitilis MA-4680 DeoR family transcriptional regulator NP_824869.1 4569451 D 227882 CDS NP_824870.1 29830236 1214687 complement(4570496..4571203) 1 NC_003155.4 TetR family transcriptional regulator 4571203 1214687 SAV_3693 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_824870.1 4570496 R 227882 CDS NP_824871.1 29830237 1210797 complement(4572086..4573081) 1 NC_003155.4 sigma-70 family; RNA polymerase sigma factor 4573081 sig30 1210797 sig30 Streptomyces avermitilis MA-4680 RNA polymerase sigma factor NP_824871.1 4572086 R 227882 CDS NP_824872.1 29830238 1210798 4573253..4573771 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; phosphinothricin N-acetyltransferase 4573771 bar 1210798 bar Streptomyces avermitilis MA-4680 phosphinothricin N-acetyltransferase NP_824872.1 4573253 D 227882 CDS NP_824873.1 29830239 1214688 complement(4573801..4574562) 1 NC_003155.4 PF02900: catalytic LigB subunit of aromatic ring-opening dioxygenase; hypothetical protein 4574562 1214688 SAV_3696 Streptomyces avermitilis MA-4680 hypothetical protein NP_824873.1 4573801 R 227882 CDS NP_824874.1 29830240 1214689 4574728..4575282 1 NC_003155.4 MarR family transcriptional regulator 4575282 1214689 SAV_3697 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_824874.1 4574728 D 227882 CDS NP_824875.1 29830241 1214690 complement(4575383..4576933) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 4576933 1214690 SAV_3698 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_824875.1 4575383 R 227882 CDS NP_824876.1 29830242 1214691 complement(4577150..4577794) 1 NC_003155.4 TetR family transcriptional regulator 4577794 1214691 SAV_3699 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_824876.1 4577150 R 227882 CDS NP_824877.1 29830243 1214692 4578033..4579352 1 NC_003155.4 hypothetical protein 4579352 1214692 SAV_3700 Streptomyces avermitilis MA-4680 hypothetical protein NP_824877.1 4578033 D 227882 CDS NP_824878.1 29830244 1214693 4579518..4581236 1 NC_003155.4 IclR family transcriptional regulator 4581236 1214693 SAV_3701 Streptomyces avermitilis MA-4680 IclR family transcriptional regulator NP_824878.1 4579518 D 227882 CDS NP_824879.1 29830245 1214694 4581428..4582084 1 NC_003155.4 TetR family transcriptional regulator 4582084 1214694 SAV_3702 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_824879.1 4581428 D 227882 CDS NP_824880.1 29830246 1214695 complement(4582127..4582990) 1 NC_003155.4 TetR family transcriptional regulator 4582990 1214695 SAV_3703 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_824880.1 4582127 R 227882 CDS NP_824881.1 29830247 1210799 complement(4583057..4584481) 1 NC_003155.4 CYP154B2, avaR is located at upstream; cytochrome P450 4584481 cyp17 1210799 cyp17 Streptomyces avermitilis MA-4680 cytochrome P450 NP_824881.1 4583057 R 227882 CDS NP_824882.1 29830248 1210800 complement(4584571..4585275) 1 NC_003155.4 gamma-butyrolactone receptor protein 4585275 avaR 1210800 avaR Streptomyces avermitilis MA-4680 gamma-butyrolactone receptor protein NP_824882.1 4584571 R 227882 CDS NP_824883.1 29830249 1214696 4585720..4587741 1 NC_003155.4 acyl-CoA oxidase 4587741 1214696 SAV_3706 Streptomyces avermitilis MA-4680 acyl-CoA oxidase NP_824883.1 4585720 D 227882 CDS NP_824884.1 29830250 1214697 4588309..4589343 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 4589343 adhA5 1214697 adhA5 Streptomyces avermitilis MA-4680 dehydrogenase NP_824884.1 4588309 D 227882 CDS NP_824885.1 29830251 1210802 complement(4590544..4591725) 1 NC_003155.4 PF00589: Phage integrase family; phage integrase 4591725 int7 1210802 int7 Streptomyces avermitilis MA-4680 phage integrase NP_824885.1 4590544 R 227882 CDS NP_824886.1 29830252 1210803 complement(4591725..4591925) 1 NC_003155.4 phage excisionase 4591925 xis 1210803 xis Streptomyces avermitilis MA-4680 phage excisionase NP_824886.1 4591725 R 227882 CDS NP_824887.1 29830253 1214698 complement(4592037..4592204) 1 NC_003155.4 hypothetical protein 4592204 1214698 SAV_3710 Streptomyces avermitilis MA-4680 hypothetical protein NP_824887.1 4592037 R 227882 CDS NP_824888.1 29830254 1214699 complement(4592396..4593871) 1 NC_003155.4 ATP-binding protein 4593871 1214699 SAV_3711 Streptomyces avermitilis MA-4680 ATP-binding protein NP_824888.1 4592396 R 227882 CDS NP_824889.1 29830255 1214700 complement(4593874..4594734) 1 NC_003155.4 hypothetical protein 4594734 1214700 SAV_3712 Streptomyces avermitilis MA-4680 hypothetical protein NP_824889.1 4593874 R 227882 CDS NP_824890.1 29830256 1214701 4594875..4595906 1 NC_003155.4 hypothetical protein 4595906 1214701 SAV_3713 Streptomyces avermitilis MA-4680 hypothetical protein NP_824890.1 4594875 D 227882 CDS NP_824891.1 29830257 1214702 complement(4595934..4596389) 1 NC_003155.4 hypothetical protein 4596389 1214702 SAV_3714 Streptomyces avermitilis MA-4680 hypothetical protein NP_824891.1 4595934 R 227882 CDS NP_824892.1 29830258 1210804 complement(4596559..4598637) 1 NC_003155.4 sporulation-related protein 4598637 traB1 1210804 traB1 Streptomyces avermitilis MA-4680 sporulation-related protein NP_824892.1 4596559 R 227882 CDS NP_824893.1 29830259 1210805 complement(4598651..4599220) 1 NC_003155.4 sporulation-related protein 4599220 traA1 1210805 traA1 Streptomyces avermitilis MA-4680 sporulation-related protein NP_824893.1 4598651 R 227882 CDS NP_824894.1 29830260 1214703 complement(4599240..4599740) 1 NC_003155.4 hypothetical protein 4599740 1214703 SAV_3717 Streptomyces avermitilis MA-4680 hypothetical protein NP_824894.1 4599240 R 227882 CDS NP_824895.1 29830261 1214704 complement(4599769..4600851) 1 NC_003155.4 PF01507: Phosphoadenosine phosphosulfate reductase family; hypothetical protein 4600851 1214704 SAV_3718 Streptomyces avermitilis MA-4680 hypothetical protein NP_824895.1 4599769 R 227882 CDS NP_824896.1 29830262 1214705 complement(4600848..4601825) 1 NC_003155.4 SpdB homolog; hypothetical protein 4601825 1214705 SAV_3719 Streptomyces avermitilis MA-4680 hypothetical protein NP_824896.1 4600848 R 227882 CDS NP_824897.1 29830263 1214706 complement(4601822..4602112) 1 NC_003155.4 hypothetical protein 4602112 1214706 SAV_3720 Streptomyces avermitilis MA-4680 hypothetical protein NP_824897.1 4601822 R 227882 CDS NP_824898.1 29830264 1214707 4602727..4603485 1 NC_003155.4 PF07702: UbiC transcription regulator-associated; GntR family transcriptional regulator 4603485 1214707 SAV_3721 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_824898.1 4602727 D 227882 CDS NP_824899.1 29830265 1214708 4605720..4607084 1 NC_003155.4 IS4 family; IS4 family transposase 4607084 1214708 SAV_3722 Streptomyces avermitilis MA-4680 IS4 family transposase NP_824899.1 4605720 D 227882 CDS NP_824900.1 29830266 1214709 complement(4607342..4608352) 1 NC_003155.4 hypothetical protein 4608352 1214709 SAV_3723 Streptomyces avermitilis MA-4680 hypothetical protein NP_824900.1 4607342 R 227882 CDS NP_824901.1 29830267 1214710 complement(4608844..4609239) 1 NC_003155.4 hypothetical protein 4609239 1214710 SAV_3724 Streptomyces avermitilis MA-4680 hypothetical protein NP_824901.1 4608844 R 227882 CDS NP_824902.1 29830268 1214711 complement(4609420..4610523) 1 NC_003155.4 hypothetical protein 4610523 1214711 SAV_3725 Streptomyces avermitilis MA-4680 hypothetical protein NP_824902.1 4609420 R 227882 CDS NP_824903.1 29830269 1214712 complement(4610608..4612356) 1 NC_003155.4 PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; hypothetical protein 4612356 1214712 SAV_3726 Streptomyces avermitilis MA-4680 hypothetical protein NP_824903.1 4610608 R 227882 CDS NP_824904.1 29830270 1214713 complement(4612749..4613219) 1 NC_003155.4 hypothetical protein 4613219 1214713 SAV_3727 Streptomyces avermitilis MA-4680 hypothetical protein NP_824904.1 4612749 R 227882 CDS NP_824905.1 29830271 1214714 complement(4614801..4615940) 1 NC_003155.4 PF00589: Phage integrase family; integrase 4615940 int8 1214714 int8 Streptomyces avermitilis MA-4680 integrase NP_824905.1 4614801 R 227882 CDS NP_824906.1 29830272 1210806 complement(4616145..4617458) 1 NC_003155.4 replication initiation protein 4617458 repSA1 1210806 repSA1 Streptomyces avermitilis MA-4680 replication initiation protein NP_824906.1 4616145 R 227882 CDS NP_824907.1 29830273 1214715 complement(4617607..4617852) 1 NC_003155.4 SpdD protein 4617852 spdD1 1214715 spdD1 Streptomyces avermitilis MA-4680 SpdD protein NP_824907.1 4617607 R 227882 CDS NP_824908.1 29830274 1214716 complement(4617877..4618071) 1 NC_003155.4 hypothetical protein 4618071 1214716 SAV_3731 Streptomyces avermitilis MA-4680 hypothetical protein NP_824908.1 4617877 R 227882 CDS NP_824909.1 29830275 1210807 complement(4618088..4618279) 1 NC_003155.4 mobile element transfer protein SpdB 4618279 spdB1 1210807 spdB1 Streptomyces avermitilis MA-4680 mobile element transfer protein SpdB NP_824909.1 4618088 R 227882 CDS NP_824910.1 29830276 1210808 complement(4618292..4618918) 1 NC_003155.4 mobile element transfer protein SpdA 4618918 spdA1 1210808 spdA1 Streptomyces avermitilis MA-4680 mobile element transfer protein SpdA NP_824910.1 4618292 R 227882 CDS NP_824911.1 29830277 1210809 complement(4619007..4620386) 1 NC_003155.4 plasmid transfer protein 4620386 traSA1 1210809 traSA1 Streptomyces avermitilis MA-4680 plasmid transfer protein NP_824911.1 4619007 R 227882 CDS NP_824912.1 29830278 1210810 complement(4620386..4620742) 1 NC_003155.4 replication activator protein Pra 4620742 pra1 1210810 pra1 Streptomyces avermitilis MA-4680 replication activator protein Pra NP_824912.1 4620386 R 227882 CDS NP_824913.1 29830279 1210811 complement(4620920..4621708) 1 NC_003155.4 PF07702: UbiC transcription regulator-associated; regulatory protein KorSA 4621708 korSA1 1210811 korSA1 Streptomyces avermitilis MA-4680 regulatory protein KorSA NP_824913.1 4620920 R 227882 CDS NP_824914.1 29830280 1214717 4621735..4622223 1 NC_003155.4 MutT-like protein 4622223 1214717 SAV_3737 Streptomyces avermitilis MA-4680 MutT-like protein NP_824914.1 4621735 D 227882 CDS NP_824915.1 29830281 1214718 4622270..4622698 1 NC_003155.4 regulatory protein 4622698 1214718 SAV_3738 Streptomyces avermitilis MA-4680 regulatory protein NP_824915.1 4622270 D 227882 CDS NP_824916.1 29830282 1214719 4622692..4623039 1 NC_003155.4 hypothetical protein 4623039 1214719 SAV_3739 Streptomyces avermitilis MA-4680 hypothetical protein NP_824916.1 4622692 D 227882 CDS NP_824917.1 29830283 1214720 4623036..4623425 1 NC_003155.4 hypothetical protein 4623425 1214720 SAV_3740 Streptomyces avermitilis MA-4680 hypothetical protein NP_824917.1 4623036 D 227882 CDS NP_824918.1 29830284 1214721 complement(4623466..4625235) 1 NC_003155.4 unclassified IS, PF00665: Integrase core domain; ISmav2-like transposase 4625235 1214721 SAV_3741 Streptomyces avermitilis MA-4680 ISmav2-like transposase NP_824918.1 4623466 R 227882 CDS NP_824919.1 29830285 1214722 complement(4626525..4627730) 1 NC_003155.4 hypothetical protein 4627730 1214722 SAV_3742 Streptomyces avermitilis MA-4680 hypothetical protein NP_824919.1 4626525 R 227882 CDS NP_824920.1 29830286 1214723 complement(4630443..4631972) 1 NC_003155.4 hypothetical protein 4631972 1214723 SAV_3743 Streptomyces avermitilis MA-4680 hypothetical protein NP_824920.1 4630443 R 227882 CDS NP_824921.1 29830287 1214724 4632395..4632796 1 NC_003155.4 hypothetical protein 4632796 1214724 SAV_3744 Streptomyces avermitilis MA-4680 hypothetical protein NP_824921.1 4632395 D 227882 CDS NP_824922.1 29830288 1214725 4633048..4633491 1 NC_003155.4 hypothetical protein 4633491 1214725 SAV_3745 Streptomyces avermitilis MA-4680 hypothetical protein NP_824922.1 4633048 D 227882 CDS NP_824923.1 29830289 1214726 4634597..4636144 1 NC_003155.4 hypothetical protein 4636144 1214726 SAV_3746 Streptomyces avermitilis MA-4680 hypothetical protein NP_824923.1 4634597 D 227882 CDS NP_824924.1 29830290 1214727 4637051..4637479 1 NC_003155.4 hypothetical protein 4637479 1214727 SAV_3747 Streptomyces avermitilis MA-4680 hypothetical protein NP_824924.1 4637051 D 227882 CDS NP_824925.1 29830291 1214728 complement(4638366..4639334) 1 NC_003155.4 hypothetical protein 4639334 1214728 SAV_3748 Streptomyces avermitilis MA-4680 hypothetical protein NP_824925.1 4638366 R 227882 CDS NP_824926.1 29830292 1214729 complement(4639693..4640202) 1 NC_003155.4 hypothetical protein 4640202 1214729 SAV_3749 Streptomyces avermitilis MA-4680 hypothetical protein NP_824926.1 4639693 R 227882 CDS NP_824927.1 29830293 1214730 4640621..4640953 1 NC_003155.4 hypothetical protein 4640953 1214730 SAV_3750 Streptomyces avermitilis MA-4680 hypothetical protein NP_824927.1 4640621 D 227882 CDS NP_824928.1 29830294 1214731 complement(4641303..4641581) 1 NC_003155.4 hypothetical protein 4641581 1214731 SAV_3751 Streptomyces avermitilis MA-4680 hypothetical protein NP_824928.1 4641303 R 227882 CDS NP_824929.1 29830295 1214732 complement(4641822..4643474) 1 NC_003155.4 PF01839: FG-GAP repeat; hypothetical protein 4643474 1214732 SAV_3752 Streptomyces avermitilis MA-4680 hypothetical protein NP_824929.1 4641822 R 227882 CDS NP_824930.1 29830296 1214733 complement(4643740..4644273) 1 NC_003155.4 hypothetical protein 4644273 1214733 SAV_3753 Streptomyces avermitilis MA-4680 hypothetical protein NP_824930.1 4643740 R 227882 CDS NP_824931.1 29830297 1214734 complement(4644830..4646323) 1 NC_003155.4 FAD-dependent oxygenase 4646323 1214734 SAV_3754 Streptomyces avermitilis MA-4680 FAD-dependent oxygenase NP_824931.1 4644830 R 227882 CDS NP_824932.1 29830298 1214735 complement(4646687..4647109) 1 NC_003155.4 PF01451: Low molecular weight phosphotyrosine protein phosphatase; low molecular weight protein tyrosine phosphatase 4647109 ptpB1 1214735 ptpB1 Streptomyces avermitilis MA-4680 low molecular weight protein tyrosine phosphatase NP_824932.1 4646687 R 227882 CDS NP_824933.1 29830299 1214736 4647099..4647371 1 NC_003155.4 hypothetical protein 4647371 1214736 SAV_3755 Streptomyces avermitilis MA-4680 hypothetical protein NP_824933.1 4647099 D 227882 CDS NP_824934.1 29830300 1214737 complement(4647424..4647828) 1 NC_003155.4 transcription regulator ArsR 4647828 1214737 SAV_3757 Streptomyces avermitilis MA-4680 transcription regulator ArsR NP_824934.1 4647424 R 227882 CDS NP_824935.1 29830301 1214738 4647908..4648378 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein 4648378 1214738 SAV_3758 Streptomyces avermitilis MA-4680 hypothetical protein NP_824935.1 4647908 D 227882 CDS NP_824936.1 29830302 1214739 complement(4648561..4649208) 1 NC_003155.4 hypothetical protein 4649208 1214739 SAV_3759 Streptomyces avermitilis MA-4680 hypothetical protein NP_824936.1 4648561 R 227882 CDS NP_824937.1 29830303 1214740 complement(4649384..4649980) 1 NC_003155.4 TetR family transcriptional regulator 4649980 1214740 SAV_3760 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_824937.1 4649384 R 227882 CDS NP_824938.1 29830304 1214741 4650129..4650857 1 NC_003155.4 PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; hypothetical protein 4650857 1214741 SAV_3761 Streptomyces avermitilis MA-4680 hypothetical protein NP_824938.1 4650129 D 227882 CDS NP_824939.1 29830305 1214742 complement(4650952..4651512) 1 NC_003155.4 hypothetical protein 4651512 1214742 SAV_3762 Streptomyces avermitilis MA-4680 hypothetical protein NP_824939.1 4650952 R 227882 CDS NP_824940.1 29830306 1214743 complement(4651594..4652211) 1 NC_003155.4 LysE family efflux protein 4652211 1214743 SAV_3763 Streptomyces avermitilis MA-4680 LysE family efflux protein NP_824940.1 4651594 R 227882 CDS NP_824941.1 29830307 1214744 4652323..4652781 1 NC_003155.4 transcription regulator AsnC 4652781 1214744 SAV_3764 Streptomyces avermitilis MA-4680 transcription regulator AsnC NP_824941.1 4652323 D 227882 CDS NP_824942.1 29830308 1214745 complement(4652819..4654066) 1 NC_003155.4 PF01041: DegT/DnrJ/EryC1/StrS aminotransferase family; hypothetical protein 4654066 1214745 SAV_3765 Streptomyces avermitilis MA-4680 hypothetical protein NP_824942.1 4652819 R 227882 CDS NP_824943.1 29830309 1214746 complement(4654181..4655296) 1 NC_003155.4 hypothetical protein 4655296 1214746 SAV_3766 Streptomyces avermitilis MA-4680 hypothetical protein NP_824943.1 4654181 R 227882 CDS NP_824944.1 29830310 1214747 4655867..4656193 1 NC_003155.4 hypothetical protein 4656193 1214747 SAV_3767 Streptomyces avermitilis MA-4680 hypothetical protein NP_824944.1 4655867 D 227882 CDS NP_824945.1 29830311 1214748 complement(4656757..4657602) 1 NC_003155.4 integral membrane protein 4657602 1214748 SAV_3768 Streptomyces avermitilis MA-4680 integral membrane protein NP_824945.1 4656757 R 227882 CDS NP_824946.1 29830312 1214749 complement(4658158..4660647) 1 NC_003155.4 PF01433: Peptidase family M1; aminopeptidase 4660647 1214749 SAV_3769 Streptomyces avermitilis MA-4680 aminopeptidase NP_824946.1 4658158 R 227882 CDS NP_824947.1 29830313 1214750 complement(4660850..4662259) 1 NC_003155.4 hypothetical protein 4662259 1214750 SAV_3770 Streptomyces avermitilis MA-4680 hypothetical protein NP_824947.1 4660850 R 227882 CDS NP_824948.1 29830314 1214751 complement(4662186..4663709) 1 NC_003155.4 PF05672: E-MAP-115 family; hypothetical protein 4663709 1214751 SAV_3771 Streptomyces avermitilis MA-4680 hypothetical protein NP_824948.1 4662186 R 227882 CDS NP_824949.1 29830315 1214752 complement(4663715..4666081) 1 NC_003155.4 hypothetical protein 4666081 1214752 SAV_3772 Streptomyces avermitilis MA-4680 hypothetical protein NP_824949.1 4663715 R 227882 CDS NP_824950.1 29830316 1214753 complement(4666101..4666883) 1 NC_003155.4 hypothetical protein 4666883 1214753 SAV_3773 Streptomyces avermitilis MA-4680 hypothetical protein NP_824950.1 4666101 R 227882 CDS NP_824951.1 29830317 1214754 4667076..4667594 1 NC_003155.4 hypothetical protein 4667594 1214754 SAV_3774 Streptomyces avermitilis MA-4680 hypothetical protein NP_824951.1 4667076 D 227882 CDS NP_824952.1 29830318 1214755 complement(4667663..4668403) 1 NC_003155.4 transcriptional regulator 4668403 1214755 SAV_3775 Streptomyces avermitilis MA-4680 transcriptional regulator NP_824952.1 4667663 R 227882 CDS NP_824953.1 29830319 1214756 complement(4668521..4669753) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; integral membrane protein 4669753 1214756 SAV_3776 Streptomyces avermitilis MA-4680 integral membrane protein NP_824953.1 4668521 R 227882 CDS NP_824954.1 29830320 1214757 4669812..4670795 1 NC_003155.4 transcriptional regulator 4670795 1214757 SAV_3777 Streptomyces avermitilis MA-4680 transcriptional regulator NP_824954.1 4669812 D 227882 CDS NP_824955.1 29830321 1210812 4670805..4671314 1 NC_003155.4 glutathione peroxidase 4671314 bsaA 1210812 bsaA Streptomyces avermitilis MA-4680 glutathione peroxidase NP_824955.1 4670805 D 227882 CDS NP_824956.1 29830322 1214758 4671387..4672286 1 NC_003155.4 MerR family transcriptional regulator 4672286 1214758 SAV_3779 Streptomyces avermitilis MA-4680 MerR family transcriptional regulator NP_824956.1 4671387 D 227882 CDS NP_824957.1 29830323 1214759 complement(4672352..4674325) 1 NC_003155.4 PF07695: 7TM diverse intracellular signalling; integral membrane protein 4674325 1214759 SAV_3780 Streptomyces avermitilis MA-4680 integral membrane protein NP_824957.1 4672352 R 227882 CDS NP_824958.1 29830324 1210813 complement(4674500..4677166) 1 NC_003155.4 PF00768: D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase 4677166 dacC 1210813 dacC Streptomyces avermitilis MA-4680 D-alanyl-D-alanine carboxypeptidase NP_824958.1 4674500 R 227882 CDS NP_824959.1 29830325 1214760 4677405..4678160 1 NC_003155.4 PF05719: Golgi phosphoprotein 3 (GPP34); hypothetical protein 4678160 1214760 SAV_3782 Streptomyces avermitilis MA-4680 hypothetical protein NP_824959.1 4677405 D 227882 CDS NP_824960.1 29830326 1214761 4678590..4679447 1 NC_003155.4 DNA-binding protein 4679447 1214761 SAV_3783 Streptomyces avermitilis MA-4680 DNA-binding protein NP_824960.1 4678590 D 227882 CDS NP_824961.1 29830327 1214762 4679677..4679886 1 NC_003155.4 PF04149: Domain of unknown function (DUF397); hypothetical protein 4679886 1214762 SAV_3784 Streptomyces avermitilis MA-4680 hypothetical protein NP_824961.1 4679677 D 227882 CDS NP_824962.1 29830328 1214763 complement(4680104..4680958) 1 NC_003155.4 hypothetical protein 4680958 1214763 SAV_3785 Streptomyces avermitilis MA-4680 hypothetical protein NP_824962.1 4680104 R 227882 CDS NP_824963.1 29830329 1214764 4681048..4681833 1 NC_003155.4 PF00106: short chain dehydrogenase; short chain dehydrogenase 4681833 1214764 SAV_3786 Streptomyces avermitilis MA-4680 short chain dehydrogenase NP_824963.1 4681048 D 227882 CDS NP_824964.1 29830330 1214765 4682066..4683634 1 NC_003155.4 PF00474: Sodium:solute symporter family; sodium-coupled permease 4683634 1214765 SAV_3787 Streptomyces avermitilis MA-4680 sodium-coupled permease NP_824964.1 4682066 D 227882 CDS NP_824965.1 29830331 1214766 complement(4683675..4684790) 1 NC_003155.4 PF03747: ADP-ribosylglycohydrolase; ADP-ribosylglycohydrolase 4684790 draG3 1214766 draG3 Streptomyces avermitilis MA-4680 ADP-ribosylglycohydrolase NP_824965.1 4683675 R 227882 CDS NP_824966.1 29830332 1214767 4684952..4686358 1 NC_003155.4 PF01839: FG-GAP repeat; hypothetical protein 4686358 1214767 SAV_3789 Streptomyces avermitilis MA-4680 hypothetical protein NP_824966.1 4684952 D 227882 CDS NP_824967.1 29830333 1210814 complement(4686492..4687670) 1 NC_003155.4 macrolide O-acyltransferase 4687670 mdmB 1210814 mdmB Streptomyces avermitilis MA-4680 macrolide O-acyltransferase NP_824967.1 4686492 R 227882 CDS NP_824968.1 29830334 1214768 4687844..4688230 1 NC_003155.4 hypothetical protein 4688230 1214768 SAV_3791 Streptomyces avermitilis MA-4680 hypothetical protein NP_824968.1 4687844 D 227882 CDS NP_824969.1 29830335 1214769 complement(4688318..4690384) 1 NC_003155.4 hypothetical protein 4690384 1214769 SAV_3792 Streptomyces avermitilis MA-4680 hypothetical protein NP_824969.1 4688318 R 227882 CDS NP_824970.1 29830336 1214770 4690672..4691025 1 NC_003155.4 hypothetical protein 4691025 1214770 SAV_3793 Streptomyces avermitilis MA-4680 hypothetical protein NP_824970.1 4690672 D 227882 CDS NP_824971.1 29830337 1214771 complement(4691032..4693617) 1 NC_003155.4 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis; FO synthase 4693617 fbiC 1214771 fbiC Streptomyces avermitilis MA-4680 FO synthase NP_824971.1 4691032 R 227882 CDS NP_824972.1 29830338 1214772 4693843..4695351 1 NC_003155.4 PF02231: PHP domain N-terminal region; protein 4695351 1214772 SAV_3795 Streptomyces avermitilis MA-4680 protein NP_824972.1 4693843 D 227882 CDS NP_824973.1 29830339 1214773 4695437..4695844 1 NC_003155.4 PF04075: Domain of unknown function (DUF385); hypothetical protein 4695844 1214773 SAV_3796 Streptomyces avermitilis MA-4680 hypothetical protein NP_824973.1 4695437 D 227882 CDS NP_824974.1 29830340 1214774 4695867..4697255 1 NC_003155.4 hypothetical protein 4697255 1214774 SAV_3797 Streptomyces avermitilis MA-4680 hypothetical protein NP_824974.1 4695867 D 227882 CDS NP_824975.1 29830341 1214775 complement(4697299..4698798) 1 NC_003155.4 PF00171: Aldehyde dehydrogenase family; aldehyde dehydrogenase 4698798 1214775 SAV_3798 Streptomyces avermitilis MA-4680 aldehyde dehydrogenase NP_824975.1 4697299 R 227882 CDS NP_824976.1 29830342 1214776 complement(4698795..4700525) 1 NC_003155.4 D-aminoacylase 4700525 1214776 SAV_3799 Streptomyces avermitilis MA-4680 D-aminoacylase NP_824976.1 4698795 R 227882 CDS NP_824977.1 29830343 1214777 complement(4700540..4701580) 1 NC_003155.4 PF00296: Luciferase-like monooxygenase; hypothetical protein 4701580 1214777 SAV_3800 Streptomyces avermitilis MA-4680 hypothetical protein NP_824977.1 4700540 R 227882 CDS NP_824978.1 29830344 1214778 complement(4701767..4702543) 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 4702543 1214778 SAV_3801 Streptomyces avermitilis MA-4680 dehydrogenase NP_824978.1 4701767 R 227882 CDS NP_824979.1 29830345 1214779 complement(4702552..4703481) 1 NC_003155.4 PF00296: Luciferase-like monooxygenase; hypothetical protein 4703481 1214779 SAV_3802 Streptomyces avermitilis MA-4680 hypothetical protein NP_824979.1 4702552 R 227882 CDS NP_824980.1 29830346 1214780 complement(4703478..4704737) 1 NC_003155.4 PF04909: Amidohydrolase; hypothetical protein 4704737 1214780 SAV_3803 Streptomyces avermitilis MA-4680 hypothetical protein NP_824980.1 4703478 R 227882 CDS NP_824981.1 29830347 1214781 4704929..4707871 1 NC_003155.4 AfsR homolog, PF03704: Bacterial transcriptional activator domain; transcriptional regulator 4707871 1214781 SAV_3804 Streptomyces avermitilis MA-4680 transcriptional regulator NP_824981.1 4704929 D 227882 CDS NP_824982.1 29830348 1214782 4708083..4708346 1 NC_003155.4 hypothetical protein 4708346 1214782 SAV_3805 Streptomyces avermitilis MA-4680 hypothetical protein NP_824982.1 4708083 D 227882 CDS NP_824983.1 29830349 1214783 complement(4708540..4710123) 1 NC_003155.4 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 4710123 fadD16 1214783 fadD16 Streptomyces avermitilis MA-4680 long-chain-fatty-acid--CoA ligase NP_824983.1 4708540 R 227882 CDS NP_824984.1 29830350 1210815 4710253..4711401 1 NC_003155.4 PF02803: Thiolase, C-terminal domain; lipid-transfer protein 4711401 ltp2 1210815 ltp2 Streptomyces avermitilis MA-4680 lipid-transfer protein NP_824984.1 4710253 D 227882 CDS NP_824985.1 29830351 1214784 4711403..4711819 1 NC_003155.4 PF01796: Domain of unknown function DUF35; hypothetical protein 4711819 1214784 SAV_3808 Streptomyces avermitilis MA-4680 hypothetical protein NP_824985.1 4711403 D 227882 CDS NP_824986.1 29830352 1210816 4711798..4712586 1 NC_003155.4 enoyl-CoA hydratase/isomerase 4712586 echA10 1210816 echA10 Streptomyces avermitilis MA-4680 enoyl-CoA hydratase/isomerase NP_824986.1 4711798 D 227882 CDS NP_824987.1 29830353 1214785 4712599..4713600 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; epoxide hydrolase 4713600 ephA2 1214785 ephA2 Streptomyces avermitilis MA-4680 epoxide hydrolase NP_824987.1 4712599 D 227882 CDS NP_824988.1 29830354 1214786 complement(4713644..4714243) 1 NC_003155.4 hypothetical protein 4714243 1214786 SAV_3811 Streptomyces avermitilis MA-4680 hypothetical protein NP_824988.1 4713644 R 227882 CDS NP_824989.1 29830355 1214787 complement(4714344..4714991) 1 NC_003155.4 hypothetical protein 4714991 1214787 SAV_3812 Streptomyces avermitilis MA-4680 hypothetical protein NP_824989.1 4714344 R 227882 CDS NP_824990.1 29830356 1214788 complement(4715060..4715671) 1 NC_003155.4 NADPH-dependent FMN reductase 4715671 1214788 SAV_3813 Streptomyces avermitilis MA-4680 NADPH-dependent FMN reductase NP_824990.1 4715060 R 227882 CDS NP_824991.1 29830357 1214789 complement(4715668..4715985) 1 NC_003155.4 PF01638: Transcriptional regulator; hypothetical protein 4715985 1214789 SAV_3814 Streptomyces avermitilis MA-4680 hypothetical protein NP_824991.1 4715668 R 227882 CDS NP_824992.1 29830358 1214790 4716009..4716572 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 4716572 1214790 SAV_3815 Streptomyces avermitilis MA-4680 dehydrogenase NP_824992.1 4716009 D 227882 CDS NP_824993.1 29830359 1210817 complement(4716713..4719061) 1 NC_003155.4 AfsK homolog; serine/threonine protein kinase 4719061 pkn7 1210817 pkn7 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_824993.1 4716713 R 227882 CDS NP_824994.1 29830360 1214791 complement(4719274..4720068) 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hydroxylase 4720068 1214791 SAV_3817 Streptomyces avermitilis MA-4680 hydroxylase NP_824994.1 4719274 R 227882 CDS NP_824995.1 29830361 1214792 4720214..4720849 1 NC_003155.4 TetR family transcriptional regulator 4720849 1214792 SAV_3818 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_824995.1 4720214 D 227882 CDS NP_824996.1 29830362 1214793 4721114..4721851 1 NC_003155.4 PF00485: Phosphoribulokinase / Uridine kinase family; putative fructose transport system kinase 4721851 frcK 1214793 frcK Streptomyces avermitilis MA-4680 putative fructose transport system kinase NP_824996.1 4721114 D 227882 CDS NP_824997.1 29830363 1214794 complement(4721838..4722311) 1 NC_003155.4 PF04075: Domain of unknown function (DUF385); hypothetical protein 4722311 1214794 SAV_3820 Streptomyces avermitilis MA-4680 hypothetical protein NP_824997.1 4721838 R 227882 CDS NP_824998.1 29830364 1210818 complement(4722311..4723552) 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 4723552 fadE9 1210818 fadE9 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_824998.1 4722311 R 227882 CDS NP_824999.1 29830365 1214795 4723667..4724836 1 NC_003155.4 PF02803: Thiolase, C-terminal domain; hypothetical protein 4724836 1214795 SAV_3822 Streptomyces avermitilis MA-4680 hypothetical protein NP_824999.1 4723667 D 227882 CDS NP_825000.1 29830366 1214796 complement(4724859..4726046) 1 NC_003155.4 hypothetical protein 4726046 1214796 SAV_3823 Streptomyces avermitilis MA-4680 hypothetical protein NP_825000.1 4724859 R 227882 CDS NP_825001.1 29830367 1214797 4726745..4727401 1 NC_003155.4 pyridoxamine 5'-phosphate oxidase 4727401 pdxH2 1214797 pdxH2 Streptomyces avermitilis MA-4680 pyridoxamine 5'-phosphate oxidase NP_825001.1 4726745 D 227882 CDS NP_825002.1 29830368 1214798 complement(4727458..4727865) 1 NC_003155.4 PF01796: Domain of unknown function DUF35; hypothetical protein 4727865 1214798 SAV_3825 Streptomyces avermitilis MA-4680 hypothetical protein NP_825002.1 4727458 R 227882 CDS NP_825003.1 29830369 1214799 complement(4727862..4728275) 1 NC_003155.4 PF07681: DoxX; hypothetical protein 4728275 1214799 SAV_3826 Streptomyces avermitilis MA-4680 hypothetical protein NP_825003.1 4727862 R 227882 CDS NP_825004.1 29830370 1214800 4728525..4729730 1 NC_003155.4 PF00743: Flavin-binding monooxygenase-like; monooxygenase 4729730 1214800 SAV_3827 Streptomyces avermitilis MA-4680 monooxygenase NP_825004.1 4728525 D 227882 CDS NP_825005.1 29830371 1214801 4730190..4732331 1 NC_003155.4 pimeloyl-CoA synthetase 4732331 1214801 SAV_3828 Streptomyces avermitilis MA-4680 pimeloyl-CoA synthetase NP_825005.1 4730190 D 227882 CDS NP_825006.1 29830372 1210819 4732417..4733256 1 NC_003155.4 enoyl-CoA hydratase 4733256 echA11 1210819 echA11 Streptomyces avermitilis MA-4680 enoyl-CoA hydratase NP_825006.1 4732417 D 227882 CDS NP_825007.1 29830373 1214802 4733339..4733938 1 NC_003155.4 PF01613: flavin reductase like domain; NADPH-flavin oxidoreductase 4733938 1214802 SAV_3830 Streptomyces avermitilis MA-4680 NADPH-flavin oxidoreductase NP_825007.1 4733339 D 227882 CDS NP_825008.1 29830374 1214803 complement(4733988..4735298) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; integral membrane protein 4735298 1214803 SAV_3831 Streptomyces avermitilis MA-4680 integral membrane protein NP_825008.1 4733988 R 227882 CDS NP_825009.1 29830375 1214804 4735370..4736383 1 NC_003155.4 AraC family transcription regulator 4736383 1214804 SAV_3832 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_825009.1 4735370 D 227882 CDS NP_825010.1 29830376 1214805 complement(4736424..4737473) 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; alcohol dehydrogenase 4737473 adhA6 1214805 adhA6 Streptomyces avermitilis MA-4680 alcohol dehydrogenase NP_825010.1 4736424 R 227882 CDS NP_825011.1 29830377 1210820 complement(4737486..4738637) 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 4738637 fadE8 1210820 fadE8 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_825011.1 4737486 R 227882 CDS NP_825012.1 29830378 1214806 complement(4738649..4739554) 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 4739554 1214806 SAV_3835 Streptomyces avermitilis MA-4680 dehydrogenase NP_825012.1 4738649 R 227882 CDS NP_825013.1 29830379 1214807 4739639..4740574 1 NC_003155.4 PF04199: Putative cyclase; cyclase 4740574 1214807 SAV_3836 Streptomyces avermitilis MA-4680 cyclase NP_825013.1 4739639 D 227882 CDS NP_825014.1 29830380 1214808 complement(4741128..4741661) 1 NC_003155.4 regulatory protein 4741661 1214808 SAV_3837 Streptomyces avermitilis MA-4680 regulatory protein NP_825014.1 4741128 R 227882 CDS NP_825015.1 29830381 1210821 complement(4742154..4743026) 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 4743026 fadE27 1210821 fadE27 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_825015.1 4742154 R 227882 CDS NP_825016.1 29830382 1210822 complement(4743032..4744186) 1 NC_003155.4 PF02770: Acyl-CoA dehydrogenase, middle domain; acyl-CoA dehydrogenase 4744186 fadE18 1210822 fadE18 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_825016.1 4743032 R 227882 CDS NP_825017.1 29830383 1214809 complement(4744186..4745454) 1 NC_003155.4 PF04909: Amidohydrolase; hypothetical protein 4745454 1214809 SAV_3840 Streptomyces avermitilis MA-4680 hypothetical protein NP_825017.1 4744186 R 227882 CDS NP_825018.1 29830384 1210823 4745600..4747099 1 NC_003155.4 similar to bifunctional enzyme MbtA: salicyl-AMP ligase + salicyl-S-ArCP synthetase. PF00501: AMP-binding enzyme; cyclohex-1-ene-1-carboxylate:CoA ligase 4747099 fadD17 1210823 fadD17 Streptomyces avermitilis MA-4680 cyclohex-1-ene-1-carboxylate:CoA ligase NP_825018.1 4745600 D 227882 CDS NP_825019.1 29830385 1214810 complement(4747103..4747615) 1 NC_003155.4 calcium binding protein 4747615 1214810 SAV_3842 Streptomyces avermitilis MA-4680 calcium binding protein NP_825019.1 4747103 R 227882 CDS NP_825020.1 29830386 1214811 complement(4747797..4748177) 1 NC_003155.4 PF01740: STAS domain; anti-sigma factor antagonist 4748177 1214811 SAV_3843 Streptomyces avermitilis MA-4680 anti-sigma factor antagonist NP_825020.1 4747797 R 227882 CDS NP_825021.1 29830387 1210824 4748570..4749151 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 4749151 sig31 1210824 sig31 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_825021.1 4748570 D 227882 CDS NP_825022.1 29830388 1214812 4749148..4750632 1 NC_003155.4 PF01391: Collagen triple helix repeat (20 copies); hypothetical protein 4750632 1214812 SAV_3845 Streptomyces avermitilis MA-4680 hypothetical protein NP_825022.1 4749148 D 227882 CDS NP_825023.1 29830389 1210825 complement(4750759..4751640) 1 NC_003155.4 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 4751640 purU 1210825 purU Streptomyces avermitilis MA-4680 formyltetrahydrofolate deformylase NP_825023.1 4750759 R 227882 CDS NP_825024.1 29830390 1214813 complement(4751772..4752272) 1 NC_003155.4 hypothetical protein 4752272 1214813 SAV_3847 Streptomyces avermitilis MA-4680 hypothetical protein NP_825024.1 4751772 R 227882 CDS NP_825025.1 29830391 1214814 4752390..4753676 1 NC_003155.4 lipoprotein 4753676 1214814 SAV_3848 Streptomyces avermitilis MA-4680 lipoprotein NP_825025.1 4752390 D 227882 CDS NP_825026.1 29830392 1214815 complement(4753710..4755389) 1 NC_003155.4 PF02757: YLP motif; hypothetical protein 4755389 1214815 SAV_3849 Streptomyces avermitilis MA-4680 hypothetical protein NP_825026.1 4753710 R 227882 CDS NP_825027.1 29830393 1214816 complement(4755648..4757033) 1 NC_003155.4 transcriptional regulator 4757033 1214816 SAV_3850 Streptomyces avermitilis MA-4680 transcriptional regulator NP_825027.1 4755648 R 227882 CDS NP_825028.1 29830394 1214817 4757351..4758004 1 NC_003155.4 hypothetical protein 4758004 1214817 SAV_3851 Streptomyces avermitilis MA-4680 hypothetical protein NP_825028.1 4757351 D 227882 CDS NP_825029.1 29830395 1214818 4758221..4759012 1 NC_003155.4 ABC transporter ATP-binding protein 4759012 1214818 SAV_3852 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_825029.1 4758221 D 227882 CDS NP_825030.1 29830396 1214819 4759009..4760643 1 NC_003155.4 integral membrane transport protein 4760643 1214819 SAV_3853 Streptomyces avermitilis MA-4680 integral membrane transport protein NP_825030.1 4759009 D 227882 CDS NP_825031.1 29830397 1214820 complement(4760834..4761757) 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 4761757 1214820 SAV_3854 Streptomyces avermitilis MA-4680 hydrolase NP_825031.1 4760834 R 227882 CDS NP_825032.1 29830398 1210826 complement(4762296..4762988) 1 NC_003155.4 iron dependent regulatory protein 4762988 ideR 1210826 ideR Streptomyces avermitilis MA-4680 iron dependent regulatory protein NP_825032.1 4762296 R 227882 CDS NP_825033.1 29830399 1214821 4763224..4763979 1 NC_003155.4 PF01380: SIS domain; hypothetical protein 4763979 1214821 SAV_3856 Streptomyces avermitilis MA-4680 hypothetical protein NP_825033.1 4763224 D 227882 CDS NP_825034.1 29830400 1214822 complement(4764023..4765453) 1 NC_003155.4 PF00989: PAS domain; hypothetical protein 4765453 1214822 SAV_3857 Streptomyces avermitilis MA-4680 hypothetical protein NP_825034.1 4764023 R 227882 CDS NP_825035.1 29830401 1210827 complement(4766266..4766940) 1 NC_003155.4 pyridoxamine 5'-phosphate oxidase 4766940 pdxH1 1210827 pdxH1 Streptomyces avermitilis MA-4680 pyridoxamine 5'-phosphate oxidase NP_825035.1 4766266 R 227882 CDS NP_825036.1 29830402 1210828 4767277..4768377 1 NC_003155.4 forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle; citrate synthase 2 4768377 citA2 1210828 citA2 Streptomyces avermitilis MA-4680 citrate synthase 2 NP_825036.1 4767277 D 227882 CDS NP_825037.1 29830403 1214823 complement(4768463..4769500) 1 NC_003155.4 PF03171: 2OG-Fe(II) oxygenase superfamily; iron/ascorbate-dependent oxidoreductase 4769500 1214823 SAV_3860 Streptomyces avermitilis MA-4680 iron/ascorbate-dependent oxidoreductase NP_825037.1 4768463 R 227882 CDS NP_825038.1 29830404 1214824 complement(4769864..4770511) 1 NC_003155.4 hypothetical protein 4770511 1214824 SAV_3861 Streptomyces avermitilis MA-4680 hypothetical protein NP_825038.1 4769864 R 227882 CDS NP_825039.1 29830405 1214825 complement(4770608..4771207) 1 NC_003155.4 TetR family transcriptional regulator 4771207 1214825 SAV_3862 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_825039.1 4770608 R 227882 CDS NP_825040.1 29830406 1210829 complement(4771195..4771929) 1 NC_003155.4 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 4771929 echA12 1210829 echA12 Streptomyces avermitilis MA-4680 enoyl-CoA hydratase NP_825040.1 4771195 R 227882 CDS NP_825041.1 29830407 1214826 complement(4771926..4773500) 1 NC_003155.4 4-coumarate:CoA ligase 4773500 1214826 SAV_3864 Streptomyces avermitilis MA-4680 4-coumarate:CoA ligase NP_825041.1 4771926 R 227882 CDS NP_825042.1 29830408 1210830 complement(4773556..4774716) 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 4774716 fadE13 1210830 fadE13 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_825042.1 4773556 R 227882 CDS NP_825043.1 29830409 1210831 complement(4774800..4776650) 1 NC_003155.4 acetyl/propionyl CoA carboxylase alpha subunit 4776650 accA2 1210831 accA2 Streptomyces avermitilis MA-4680 acetyl/propionyl CoA carboxylase alpha subunit NP_825043.1 4774800 R 227882 CDS NP_825044.1 29830410 1210832 complement(4776661..4778259) 1 NC_003155.4 acetyl/propionyl CoA carboxylase, beta subunit 4778259 accD2 1210832 accD2 Streptomyces avermitilis MA-4680 acetyl/propionyl CoA carboxylase, beta subunit NP_825044.1 4776661 R 227882 CDS NP_825045.1 29830411 1214827 complement(4778256..4779944) 1 NC_003155.4 PF07287: Protein of unknown function (DUF1446); hypothetical protein 4779944 1214827 SAV_3868 Streptomyces avermitilis MA-4680 hypothetical protein NP_825045.1 4778256 R 227882 CDS NP_825046.1 29830412 1214828 complement(4779941..4780744) 1 NC_003155.4 PF07398: Protein of unknown function (DUF1503); hypothetical protein 4780744 1214828 SAV_3869 Streptomyces avermitilis MA-4680 hypothetical protein NP_825046.1 4779941 R 227882 CDS NP_825047.1 29830413 1210833 complement(4780954..4782675) 1 NC_003155.4 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 4782675 malS2 1210833 malS2 Streptomyces avermitilis MA-4680 malate dehydrogenase NP_825047.1 4780954 R 227882 CDS NP_825048.1 29830414 1214829 complement(4782844..4783797) 1 NC_003155.4 PF00892: Integral membrane protein DUF6; integral membrane protein 4783797 1214829 SAV_3871 Streptomyces avermitilis MA-4680 integral membrane protein NP_825048.1 4782844 R 227882 CDS NP_825049.1 29830415 1214830 complement(4783941..4786316) 1 NC_003155.4 ABC transporter ATP-binding protein 4786316 1214830 SAV_3872 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_825049.1 4783941 R 227882 CDS NP_825050.1 29830416 1214831 4786449..4786634 1 NC_003155.4 hypothetical protein 4786634 1214831 SAV_3873 Streptomyces avermitilis MA-4680 hypothetical protein NP_825050.1 4786449 D 227882 CDS NP_825051.1 29830417 1214832 complement(4786855..4787421) 1 NC_003155.4 hypothetical protein 4787421 1214832 SAV_3874 Streptomyces avermitilis MA-4680 hypothetical protein NP_825051.1 4786855 R 227882 CDS NP_825052.1 29830418 1214833 complement(4787452..4787994) 1 NC_003155.4 hypothetical protein 4787994 1214833 SAV_3875 Streptomyces avermitilis MA-4680 hypothetical protein NP_825052.1 4787452 R 227882 CDS NP_825053.1 29830419 1214834 complement(4788125..4791073) 1 NC_003155.4 PF01565: FAD binding domain; oxidoreductase 4791073 1214834 SAV_3876 Streptomyces avermitilis MA-4680 oxidoreductase NP_825053.1 4788125 R 227882 CDS NP_825054.1 29830420 1210834 4791417..4793657 1 NC_003155.4 multi-component regulatory system-9; sensor-like histidine kinase 4793657 cvnA9 1210834 cvnA9 Streptomyces avermitilis MA-4680 sensor-like histidine kinase NP_825054.1 4791417 D 227882 CDS NP_825055.1 29830421 1210835 4793654..4794061 1 NC_003155.4 multi-component regulatory system-9, PF03259: Roadblock/LC7 domain; hypothetical protein 4794061 cvnB9 1210835 cvnB9 Streptomyces avermitilis MA-4680 hypothetical protein NP_825055.1 4793654 D 227882 CDS NP_825056.1 29830422 1210836 4794058..4794405 1 NC_003155.4 multi-component regulatory system-9, PF05331: Protein of unknown function (DUF742); hypothetical protein 4794405 cvnC9 1210836 cvnC9 Streptomyces avermitilis MA-4680 hypothetical protein NP_825056.1 4794058 D 227882 CDS NP_825057.1 29830423 1210837 4794479..4795021 1 NC_003155.4 multi-component regulatory system-9; ATP/GTP-binding protein 4795021 cvnD9 1210837 cvnD9 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_825057.1 4794479 D 227882 CDS NP_825058.1 29830424 1210838 4795018..4796253 1 NC_003155.4 CYP157A2, adjacent to multi-component regulatory system-9; cytochrome P450 hydroxylase 4796253 cyp18 1210838 cyp18 Streptomyces avermitilis MA-4680 cytochrome P450 hydroxylase NP_825058.1 4795018 D 227882 CDS NP_825059.1 29830425 1210839 4796250..4797452 1 NC_003155.4 CYP154C2, adjacent to CYP157A2; cytochrome P450 hydroxylase 4797452 cyp19 1210839 cyp19 Streptomyces avermitilis MA-4680 cytochrome P450 hydroxylase NP_825059.1 4796250 D 227882 CDS NP_825060.1 29830426 1214835 4797602..4798720 1 NC_003155.4 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; phosphoserine aminotransferase 4798720 serC 1214835 serC Streptomyces avermitilis MA-4680 phosphoserine aminotransferase NP_825060.1 4797602 D 227882 CDS NP_825061.1 29830427 1214836 complement(4798865..4799851) 1 NC_003155.4 hypothetical protein 4799851 1214836 SAV_3884 Streptomyces avermitilis MA-4680 hypothetical protein NP_825061.1 4798865 R 227882 CDS NP_825062.1 29830428 1214837 4799980..4800666 1 NC_003155.4 PF00657: GDSL-like Lipase/Acylhydrolase; hypothetical protein 4800666 1214837 SAV_3885 Streptomyces avermitilis MA-4680 hypothetical protein NP_825062.1 4799980 D 227882 CDS NP_825063.1 29830429 1214838 complement(4800887..4801681) 1 NC_003155.4 PF02353: Cyclopropane-fatty-acyl-phospholipid synthase; hypothetical protein 4801681 1214838 SAV_3886 Streptomyces avermitilis MA-4680 hypothetical protein NP_825063.1 4800887 R 227882 CDS NP_825064.1 29830430 1214839 complement(4801758..4803293) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 4803293 1214839 SAV_3887 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_825064.1 4801758 R 227882 CDS NP_825065.1 29830431 1210840 4803733..4804431 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 4804431 sig32 1210840 sig32 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_825065.1 4803733 D 227882 CDS NP_825066.1 29830432 1214840 4804428..4805537 1 NC_003155.4 hypothetical protein 4805537 1214840 SAV_3889 Streptomyces avermitilis MA-4680 hypothetical protein NP_825066.1 4804428 D 227882 CDS NP_825067.1 29830433 1214841 complement(4805796..4806788) 1 NC_003155.4 PF00248: Aldo/keto reductase family; NDP-4-keto-6-deoxy-L-hexose 2,3-reductase 4806788 1214841 SAV_3890 Streptomyces avermitilis MA-4680 NDP-4-keto-6-deoxy-L-hexose 2,3-reductase NP_825067.1 4805796 R 227882 CDS NP_825068.1 29830434 1214842 complement(4806853..4807905) 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; quinone oxidoreductase 4807905 1214842 SAV_3891 Streptomyces avermitilis MA-4680 quinone oxidoreductase NP_825068.1 4806853 R 227882 CDS NP_825069.1 29830435 1214843 complement(4808237..4808809) 1 NC_003155.4 PF02834: 2',5' RNA ligase family; hypothetical protein 4808809 1214843 SAV_3892 Streptomyces avermitilis MA-4680 hypothetical protein NP_825069.1 4808237 R 227882 CDS NP_825070.1 29830436 1214844 4808855..4809367 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; hypothetical protein 4809367 1214844 SAV_3893 Streptomyces avermitilis MA-4680 hypothetical protein NP_825070.1 4808855 D 227882 CDS NP_825071.1 29830437 1214845 complement(4809411..4810757) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; integral membrane efflux protein 4810757 1214845 SAV_3894 Streptomyces avermitilis MA-4680 integral membrane efflux protein NP_825071.1 4809411 R 227882 CDS NP_825072.1 29830438 1214846 complement(4810885..4811322) 1 NC_003155.4 MarR family transcriptional regulator 4811322 1214846 SAV_3895 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_825072.1 4810885 R 227882 CDS NP_825073.1 29830439 1214847 4811516..4811698 1 NC_003155.4 hypothetical protein 4811698 1214847 SAV_3896 Streptomyces avermitilis MA-4680 hypothetical protein NP_825073.1 4811516 D 227882 CDS NP_825074.1 29830440 1214848 complement(4811717..4813168) 1 NC_003155.4 PF00860: Permease family; permease 4813168 1214848 SAV_3897 Streptomyces avermitilis MA-4680 permease NP_825074.1 4811717 R 227882 CDS NP_825075.1 29830441 1214849 4813428..4813694 1 NC_003155.4 integral membrane protein 4813694 1214849 SAV_3898 Streptomyces avermitilis MA-4680 integral membrane protein NP_825075.1 4813428 D 227882 CDS NP_825076.1 29830442 1214850 4813851..4816244 1 NC_003155.4 PF00122: E1-E2 ATPase; integral membrane ATPase 4816244 ctpE 1214850 ctpE Streptomyces avermitilis MA-4680 integral membrane ATPase NP_825076.1 4813851 D 227882 CDS NP_825077.1 29830443 1214851 complement(4816257..4817168) 1 NC_003155.4 hypothetical protein 4817168 1214851 SAV_3900 Streptomyces avermitilis MA-4680 hypothetical protein NP_825077.1 4816257 R 227882 CDS NP_825078.1 29830444 1214852 complement(4817419..4820703) 1 NC_003155.4 hypothetical protein 4820703 1214852 SAV_3901 Streptomyces avermitilis MA-4680 hypothetical protein NP_825078.1 4817419 R 227882 CDS NP_825079.1 29830445 1214853 complement(4821179..4822105) 1 NC_003155.4 hypothetical protein 4822105 1214853 SAV_3902 Streptomyces avermitilis MA-4680 hypothetical protein NP_825079.1 4821179 R 227882 CDS NP_825080.1 29830446 1214854 4822801..4824225 1 NC_003155.4 PF07690: Major Facilitator Superfamily; integral membrane protein 4824225 1214854 SAV_3903 Streptomyces avermitilis MA-4680 integral membrane protein NP_825080.1 4822801 D 227882 CDS NP_825081.1 29830447 1214855 4824479..4824937 1 NC_003155.4 lipoprotein 4824937 1214855 SAV_3904 Streptomyces avermitilis MA-4680 lipoprotein NP_825081.1 4824479 D 227882 CDS NP_825082.1 29830448 1214856 4824994..4825665 1 NC_003155.4 PF01048: Phosphorylase family; hypothetical protein 4825665 1214856 SAV_3905 Streptomyces avermitilis MA-4680 hypothetical protein NP_825082.1 4824994 D 227882 CDS NP_825083.1 29830449 1214857 4825655..4826509 1 NC_003155.4 PF02642: Uncharacterized ACR, COG2107; hypothetical protein 4826509 1214857 SAV_3906 Streptomyces avermitilis MA-4680 hypothetical protein NP_825083.1 4825655 D 227882 CDS NP_825084.1 29830450 1210841 complement(4826562..4826945) 1 NC_003155.4 cold shock protein 4826945 cspB1 1210841 cspB1 Streptomyces avermitilis MA-4680 cold shock protein NP_825084.1 4826562 R 227882 CDS NP_825085.1 29830451 1214858 complement(4827361..4827990) 1 NC_003155.4 PF00702: haloacid dehalogenase-like hydrolase; hydrolase 4827990 1214858 SAV_3908 Streptomyces avermitilis MA-4680 hydrolase NP_825085.1 4827361 R 227882 CDS NP_825086.1 29830452 1214859 complement(4828326..4828865) 1 NC_003155.4 hypothetical protein 4828865 1214859 SAV_3909 Streptomyces avermitilis MA-4680 hypothetical protein NP_825086.1 4828326 R 227882 CDS NP_825087.1 29830453 1214860 4829201..4829344 1 NC_003155.4 hypothetical protein 4829344 1214860 SAV_3910 Streptomyces avermitilis MA-4680 hypothetical protein NP_825087.1 4829201 D 227882 CDS NP_825088.1 29830454 1214861 4829509..4832091 1 NC_003155.4 hypothetical protein 4832091 1214861 SAV_3911 Streptomyces avermitilis MA-4680 hypothetical protein NP_825088.1 4829509 D 227882 CDS NP_825089.1 29830455 1214862 4832156..4833799 1 NC_003155.4 ATP-dependent DNA helicase 4833799 1214862 SAV_3912 Streptomyces avermitilis MA-4680 ATP-dependent DNA helicase NP_825089.1 4832156 D 227882 CDS NP_825090.1 29830456 1214863 complement(4833757..4834953) 1 NC_003155.4 hypothetical protein 4834953 1214863 SAV_3913 Streptomyces avermitilis MA-4680 hypothetical protein NP_825090.1 4833757 R 227882 CDS NP_825091.1 29830457 1214864 complement(4835338..4835589) 1 NC_003155.4 hypothetical protein 4835589 1214864 SAV_3914 Streptomyces avermitilis MA-4680 hypothetical protein NP_825091.1 4835338 R 227882 CDS NP_825092.1 29830458 1210842 4835900..4837948 1 NC_003155.4 ATP-dependent DNA helicase 4837948 helD 1210842 helD Streptomyces avermitilis MA-4680 ATP-dependent DNA helicase NP_825092.1 4835900 D 227882 CDS NP_825093.1 29830459 1214865 complement(4838061..4839290) 1 NC_003155.4 protein 4839290 1214865 SAV_3916 Streptomyces avermitilis MA-4680 protein NP_825093.1 4838061 R 227882 CDS NP_825094.1 29830460 1214866 complement(4839478..4840176) 1 NC_003155.4 homeostasis protein 4840176 1214866 SAV_3917 Streptomyces avermitilis MA-4680 homeostasis protein NP_825094.1 4839478 R 227882 CDS NP_825095.1 29830461 1214867 complement(4840365..4841042) 1 NC_003155.4 hypothetical protein 4841042 1214867 SAV_3918 Streptomyces avermitilis MA-4680 hypothetical protein NP_825095.1 4840365 R 227882 CDS NP_825096.1 29830462 1214868 4841081..4841758 1 NC_003155.4 PF01966: HD domain; hypothetical protein 4841758 1214868 SAV_3919 Streptomyces avermitilis MA-4680 hypothetical protein NP_825096.1 4841081 D 227882 CDS NP_825097.1 29830463 1214869 4841782..4842768 1 NC_003155.4 PF00494: Squalene/phytoene synthase; phytoene synthase 4842768 1214869 SAV_3920 Streptomyces avermitilis MA-4680 phytoene synthase NP_825097.1 4841782 D 227882 CDS NP_825098.1 29830464 1214870 complement(4842758..4843042) 1 NC_003155.4 hypothetical protein 4843042 1214870 SAV_3921 Streptomyces avermitilis MA-4680 hypothetical protein NP_825098.1 4842758 R 227882 CDS NP_825099.1 29830465 1214871 complement(4843039..4843422) 1 NC_003155.4 hypothetical protein 4843422 1214871 SAV_3922 Streptomyces avermitilis MA-4680 hypothetical protein NP_825099.1 4843039 R 227882 CDS NP_825100.1 29830466 1214872 4843479..4844405 1 NC_003155.4 transcriptional regulator 4844405 1214872 SAV_3923 Streptomyces avermitilis MA-4680 transcriptional regulator NP_825100.1 4843479 D 227882 CDS NP_825101.1 29830467 1214873 4844522..4845457 1 NC_003155.4 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid-6-phosphate etherase 4845457 murQ 1214873 murQ Streptomyces avermitilis MA-4680 N-acetylmuramic acid-6-phosphate etherase NP_825101.1 4844522 D 227882 CDS NP_825102.1 29830468 1214874 4845474..4847111 1 NC_003155.4 PF02378: phosphotransferase system EIIC, PF00367: phosphotransferase system EIIB; PTS sucrose-specific enzyme IIBC component 4847111 scrA 1214874 scrA Streptomyces avermitilis MA-4680 PTS sucrose-specific enzyme IIBC component NP_825102.1 4845474 D 227882 CDS NP_825103.1 29830469 1214875 4847108..4847695 1 NC_003155.4 hypothetical protein 4847695 1214875 SAV_3926 Streptomyces avermitilis MA-4680 hypothetical protein NP_825103.1 4847108 D 227882 CDS NP_825104.1 29830470 1214876 4847846..4848223 1 NC_003155.4 PF01740: STAS domain; anti-sigma factor antagonist 4848223 1214876 SAV_3927 Streptomyces avermitilis MA-4680 anti-sigma factor antagonist NP_825104.1 4847846 D 227882 CDS NP_825105.1 29830471 1214877 4848241..4849965 1 NC_003155.4 PF00989: PAS domain; magnesium or manganese-dependent protein phosphatase 4849965 prpJ6 1214877 prpJ6 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_825105.1 4848241 D 227882 CDS NP_825106.1 29830472 1214878 complement(4850060..4851187) 1 NC_003155.4 PF00724: NADH:flavin oxidoreductase / NADH oxidase family; oxidoreductase 4851187 1214878 SAV_3929 Streptomyces avermitilis MA-4680 oxidoreductase NP_825106.1 4850060 R 227882 CDS NP_825107.1 29830473 1214879 4851499..4854066 1 NC_003155.4 hypothetical protein 4854066 1214879 SAV_3930 Streptomyces avermitilis MA-4680 hypothetical protein NP_825107.1 4851499 D 227882 CDS NP_825108.1 29830474 1210843 complement(4854193..4855818) 1 NC_003155.4 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 4855818 groEL 1210843 groEL Streptomyces avermitilis MA-4680 chaperonin GroEL NP_825108.1 4854193 R 227882 CDS NP_825109.1 29830475 1210844 complement(4856153..4856359) 1 NC_003155.4 cold shock protein 4856359 cspB2 1210844 cspB2 Streptomyces avermitilis MA-4680 cold shock protein NP_825109.1 4856153 R 227882 CDS NP_825110.1 29830476 1214880 complement(4856813..4857088) 1 NC_003155.4 PF02597: ThiS family; hypothetical protein 4857088 1214880 SAV_3933 Streptomyces avermitilis MA-4680 hypothetical protein NP_825110.1 4856813 R 227882 CDS NP_825111.1 29830477 1210845 complement(4857164..4858462) 1 NC_003155.4 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 4858462 thrC3 1210845 thrC3 Streptomyces avermitilis MA-4680 threonine synthase NP_825111.1 4857164 R 227882 CDS NP_825112.1 29830478 1214881 4858803..4859747 1 NC_003155.4 PF00535: Glycosyl transferase; putative glucosyl-3-phosphoglycerate synthase 4859747 1214881 SAV_3935 Streptomyces avermitilis MA-4680 putative glucosyl-3-phosphoglycerate synthase NP_825112.1 4858803 D 227882 CDS NP_825113.1 29830479 1214882 4859857..4861248 1 NC_003155.4 trehalose-6-phosphate synthase 4861248 otsA 1214882 otsA Streptomyces avermitilis MA-4680 trehalose-6-phosphate synthase NP_825113.1 4859857 D 227882 CDS NP_825114.1 29830480 1214883 complement(4861292..4862155) 1 NC_003155.4 trehalose-6-phosphatase 4862155 otsB 1214883 otsB Streptomyces avermitilis MA-4680 trehalose-6-phosphatase NP_825114.1 4861292 R 227882 CDS NP_825115.1 29830481 1214884 complement(4862257..4862502) 1 NC_003155.4 hypothetical protein 4862502 1214884 SAV_3938 Streptomyces avermitilis MA-4680 hypothetical protein NP_825115.1 4862257 R 227882 CDS NP_825116.1 29830482 1214885 complement(4862584..4863861) 1 NC_003155.4 ABC transporter substrate-binding protein 4863861 1214885 SAV_3939 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_825116.1 4862584 R 227882 CDS NP_825117.1 29830483 1214886 4864012..4864917 1 NC_003155.4 transcriptional regulator 4864917 1214886 SAV_3940 Streptomyces avermitilis MA-4680 transcriptional regulator NP_825117.1 4864012 D 227882 CDS NP_825118.1 29830484 1210846 4864917..4866062 1 NC_003155.4 N-acetylglucosamine-6-phosphate deacetylase 4866062 nagA 1210846 nagA Streptomyces avermitilis MA-4680 N-acetylglucosamine-6-phosphate deacetylase NP_825118.1 4864917 D 227882 CDS NP_825119.1 29830485 1214887 4866207..4867136 1 NC_003155.4 sugar kinase 4867136 1214887 SAV_3942 Streptomyces avermitilis MA-4680 sugar kinase NP_825119.1 4866207 D 227882 CDS NP_825120.1 29830486 1214888 complement(4867210..4868160) 1 NC_003155.4 dimeric protein 4868160 1214888 SAV_3943 Streptomyces avermitilis MA-4680 dimeric protein NP_825120.1 4867210 R 227882 CDS NP_825121.1 29830487 1214889 complement(4868278..4869984) 1 NC_003155.4 PF00990: GGDEF domain; hypothetical protein 4869984 1214889 SAV_3944 Streptomyces avermitilis MA-4680 hypothetical protein NP_825121.1 4868278 R 227882 CDS NP_825122.1 29830488 1214890 4870392..4870970 1 NC_003155.4 flavin-dependent reductase 4870970 thiX2 1214890 thiX2 Streptomyces avermitilis MA-4680 flavin-dependent reductase NP_825122.1 4870392 D 227882 CDS NP_825123.1 29830489 1214891 complement(4871149..4871577) 1 NC_003155.4 PF00472: Peptidyl-tRNA hydrolase domain; peptidyl-tRNA hydrolase domain protein 4871577 1214891 SAV_3946 Streptomyces avermitilis MA-4680 peptidyl-tRNA hydrolase domain protein NP_825123.1 4871149 R 227882 CDS NP_825124.1 29830490 1214892 4871772..4872347 1 NC_003155.4 PF02342: Bacterial stress protein; tellurium resistance protein 4872347 terD2 1214892 terD2 Streptomyces avermitilis MA-4680 tellurium resistance protein NP_825124.1 4871772 D 227882 CDS NP_825125.1 29830491 1214893 complement(4872707..4873561) 1 NC_003155.4 DNA-binding protein 4873561 1214893 SAV_3948 Streptomyces avermitilis MA-4680 DNA-binding protein NP_825125.1 4872707 R 227882 CDS NP_825126.1 29830492 1214894 4873781..4874197 1 NC_003155.4 regulatory protein 4874197 1214894 SAV_3949 Streptomyces avermitilis MA-4680 regulatory protein NP_825126.1 4873781 D 227882 CDS NP_825127.1 29830493 1214895 4874208..4875164 1 NC_003155.4 mutT-like protein 4875164 1214895 SAV_3950 Streptomyces avermitilis MA-4680 mutT-like protein NP_825127.1 4874208 D 227882 CDS NP_825128.2 57833861 1214896 4875231..4876352 1 NC_003155.4 IS630 family transposase 4876352 1214896 SAV_3951 Streptomyces avermitilis MA-4680 IS630 family transposase NP_825128.2 4875231 D 227882 CDS NP_825129.1 29830495 1214897 complement(4876393..4877802) 1 NC_003155.4 PF01433: Peptidase family M1; metallopeptidase 4877802 1214897 SAV_3952 Streptomyces avermitilis MA-4680 metallopeptidase NP_825129.1 4876393 R 227882 CDS NP_825130.1 29830496 1214898 4877882..4878382 1 NC_003155.4 hypothetical protein 4878382 1214898 SAV_3953 Streptomyces avermitilis MA-4680 hypothetical protein NP_825130.1 4877882 D 227882 CDS NP_825131.1 29830497 1214899 complement(4878430..4879224) 1 NC_003155.4 PF00805: Pentapeptide repeats (8 copies); hypothetical protein 4879224 1214899 SAV_3954 Streptomyces avermitilis MA-4680 hypothetical protein NP_825131.1 4878430 R 227882 CDS NP_825132.1 29830498 1214900 4879303..4880472 1 NC_003155.4 PF01593: Flavin containing amine oxidoreductase; hypothetical protein 4880472 1214900 SAV_3955 Streptomyces avermitilis MA-4680 hypothetical protein NP_825132.1 4879303 D 227882 CDS NP_825133.1 29830499 1214901 4880526..4881515 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 4881515 1214901 SAV_3956 Streptomyces avermitilis MA-4680 dehydrogenase NP_825133.1 4880526 D 227882 CDS NP_825134.1 29830500 1214902 4881639..4883138 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 4883138 1214902 SAV_3957 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_825134.1 4881639 D 227882 CDS NP_825135.1 29830501 1214903 complement(4883217..4883690) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 4883690 1214903 SAV_3958 Streptomyces avermitilis MA-4680 acetyltransferase NP_825135.1 4883217 R 227882 CDS NP_825136.1 29830502 1214904 complement(4883778..4885193) 1 NC_003155.4 PF01266: FAD dependent oxidoreductase; hypothetical protein 4885193 1214904 SAV_3959 Streptomyces avermitilis MA-4680 hypothetical protein NP_825136.1 4883778 R 227882 CDS NP_825137.1 29830503 1214905 complement(4885204..4885794) 1 NC_003155.4 hypothetical protein 4885794 1214905 SAV_3960 Streptomyces avermitilis MA-4680 hypothetical protein NP_825137.1 4885204 R 227882 CDS NP_825138.1 29830504 1210847 4885883..4886776 1 NC_003155.4 hydroxyurea resistance protein, PF04655: Aminoglycoside/hydroxyurea antibiotic resistance kinase; hydroxyurea phosphotransferase 4886776 hur 1210847 hur Streptomyces avermitilis MA-4680 hydroxyurea phosphotransferase NP_825138.1 4885883 D 227882 CDS NP_825139.1 29830505 1210849 4887143..4888279 1 NC_003155.4 ABC transporter ATP-binding protein 4888279 msiK 1210849 msiK Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_825139.1 4887143 D 227882 CDS NP_825140.1 29830506 1214906 4888508..4888966 1 NC_003155.4 hypothetical protein 4888966 1214906 SAV_3963 Streptomyces avermitilis MA-4680 hypothetical protein NP_825140.1 4888508 D 227882 CDS NP_825141.1 29830507 1214907 4889067..4889798 1 NC_003155.4 PF00483: Nucleotidyl transferase; guanyltransferase 4889798 1214907 SAV_3964 Streptomyces avermitilis MA-4680 guanyltransferase NP_825141.1 4889067 D 227882 CDS NP_825142.1 29830508 1214908 complement(4889986..4891683) 1 NC_003155.4 PF07681: DoxX; integral membrane protein 4891683 1214908 SAV_3965 Streptomyces avermitilis MA-4680 integral membrane protein NP_825142.1 4889986 R 227882 CDS NP_825143.1 29830509 1214909 complement(4891822..4892763) 1 NC_003155.4 PF00588: SpoU rRNA Methylase family; tRNA/rRNA methyltransferase 4892763 1214909 SAV_3966 Streptomyces avermitilis MA-4680 tRNA/rRNA methyltransferase NP_825143.1 4891822 R 227882 CDS NP_825144.1 29830510 1210850 complement(4892866..4894266) 1 NC_003155.4 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 4894266 cysS 1210850 cysS Streptomyces avermitilis MA-4680 cysteinyl-tRNA synthetase NP_825144.1 4892866 R 227882 CDS NP_825145.1 29830511 1210851 complement(4894477..4895001) 1 NC_003155.4 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4895001 ispF 1210851 ispF Streptomyces avermitilis MA-4680 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase NP_825145.1 4894477 R 227882 CDS NP_825146.1 29830512 1210852 complement(4894991..4895743) 1 NC_003155.4 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 4895743 ispD 1210852 ispD Streptomyces avermitilis MA-4680 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase NP_825146.1 4894991 R 227882 CDS NP_825147.1 29830513 1214910 complement(4896097..4896579) 1 NC_003155.4 CarD-like transcriptional regulator 4896579 1214910 SAV_3970 Streptomyces avermitilis MA-4680 CarD-like transcriptional regulator NP_825147.1 4896097 R 227882 CDS NP_825148.1 29830514 1214911 4897210..4897872 1 NC_003155.4 PF04314: Protein of unknown function (DUF461); lipoprotein 4897872 1214911 SAV_3971 Streptomyces avermitilis MA-4680 lipoprotein NP_825148.1 4897210 D 227882 CDS NP_825149.1 29830515 1214912 complement(4898071..4898742) 1 NC_003155.4 two-component system response regulator 4898742 phoP 1214912 phoP Streptomyces avermitilis MA-4680 two-component system response regulator NP_825149.1 4898071 R 227882 CDS NP_825150.1 29830516 1214913 complement(4898748..4900025) 1 NC_003155.4 two-component system sensor kinase 4900025 phoR 1214913 phoR Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_825150.1 4898748 R 227882 CDS NP_825151.1 29830517 1210853 4900250..4900939 1 NC_003155.4 phosphate transport system regulatory protein 4900939 phoU 1210853 phoU Streptomyces avermitilis MA-4680 phosphate transport system regulatory protein NP_825151.1 4900250 D 227882 CDS NP_825152.1 29830518 1214914 complement(4901155..4901307) 1 NC_003155.4 hypothetical protein 4901307 1214914 SAV_3975 Streptomyces avermitilis MA-4680 hypothetical protein NP_825152.1 4901155 R 227882 CDS NP_825153.1 29830519 1214915 complement(4901452..4902474) 1 NC_003155.4 PF00248: Aldo/keto reductase family; oxidoreductase 4902474 1214915 SAV_3976 Streptomyces avermitilis MA-4680 oxidoreductase NP_825153.1 4901452 R 227882 CDS NP_825154.1 29830520 1214916 4902641..4903567 1 NC_003155.4 AraC family transcription regulator 4903567 1214916 SAV_3977 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_825154.1 4902641 D 227882 CDS NP_825155.1 29830521 1214917 complement(4903668..4904975) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; integral membrane transport protein 4904975 1214917 SAV_3978 Streptomyces avermitilis MA-4680 integral membrane transport protein NP_825155.1 4903668 R 227882 CDS NP_825156.1 29830522 1210854 4905162..4905923 1 NC_003155.4 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 4905923 gpmA 1210854 gpmA Streptomyces avermitilis MA-4680 phosphoglyceromutase NP_825156.1 4905162 D 227882 CDS NP_825157.1 29830523 1214918 complement(4906639..4907955) 1 NC_003155.4 PF00589: Phage integrase family; phage-related integrase 4907955 int9 1214918 int9 Streptomyces avermitilis MA-4680 phage-related integrase NP_825157.1 4906639 R 227882 CDS NP_825158.1 29830524 1214919 complement(4907955..4908194) 1 NC_003155.4 hypothetical protein 4908194 1214919 SAV_3981 Streptomyces avermitilis MA-4680 hypothetical protein NP_825158.1 4907955 R 227882 CDS NP_825159.1 29830525 1210855 complement(4908187..4909554) 1 NC_003155.4 replication initiation protein 4909554 repSA2 1210855 repSA2 Streptomyces avermitilis MA-4680 replication initiation protein NP_825159.1 4908187 R 227882 CDS NP_825160.1 29830526 1210856 complement(4909627..4909908) 1 NC_003155.4 SpdD protein 4909908 spdD2 1210856 spdD2 Streptomyces avermitilis MA-4680 SpdD protein NP_825160.1 4909627 R 227882 CDS NP_825161.1 29830527 1214920 complement(4909901..4910095) 1 NC_003155.4 hypothetical protein 4910095 1214920 SAV_3984 Streptomyces avermitilis MA-4680 hypothetical protein NP_825161.1 4909901 R 227882 CDS NP_825162.1 29830528 1210857 complement(4910112..4910303) 1 NC_003155.4 mobile element transfer protein SpdB 4910303 spdB2 1210857 spdB2 Streptomyces avermitilis MA-4680 mobile element transfer protein SpdB NP_825162.1 4910112 R 227882 CDS NP_825163.1 29830529 1210858 complement(4910315..4910944) 1 NC_003155.4 mobile element transfer protein SpdA 4910944 spdA2 1210858 spdA2 Streptomyces avermitilis MA-4680 mobile element transfer protein SpdA NP_825163.1 4910315 R 227882 CDS NP_825164.1 29830530 1210859 complement(4911150..4912445) 1 NC_003155.4 plasmid transfer protein 4912445 traSA2 1210859 traSA2 Streptomyces avermitilis MA-4680 plasmid transfer protein NP_825164.1 4911150 R 227882 CDS NP_825165.1 29830531 1210860 complement(4912445..4912801) 1 NC_003155.4 replication activator protein Pra 4912801 pra2 1210860 pra2 Streptomyces avermitilis MA-4680 replication activator protein Pra NP_825165.1 4912445 R 227882 CDS NP_825166.1 29830532 1210861 complement(4912971..4913759) 1 NC_003155.4 PF07702: UbiC transcription regulator-associated; regulatory protein KorSA 4913759 korSA2 1210861 korSA2 Streptomyces avermitilis MA-4680 regulatory protein KorSA NP_825166.1 4912971 R 227882 CDS NP_825167.1 29830533 1214921 4913786..4914274 1 NC_003155.4 MutT-like protein 4914274 1214921 SAV_3990 Streptomyces avermitilis MA-4680 MutT-like protein NP_825167.1 4913786 D 227882 CDS NP_825168.1 29830534 1214922 4914291..4914755 1 NC_003155.4 regulatory protein 4914755 1214922 SAV_3991 Streptomyces avermitilis MA-4680 regulatory protein NP_825168.1 4914291 D 227882 CDS NP_825169.1 29830535 1214923 4914749..4915141 1 NC_003155.4 hypothetical protein 4915141 1214923 SAV_3992 Streptomyces avermitilis MA-4680 hypothetical protein NP_825169.1 4914749 D 227882 CDS NP_825170.1 29830536 1214924 complement(4915182..4915616) 1 NC_003155.4 hypothetical protein 4915616 1214924 SAV_3993 Streptomyces avermitilis MA-4680 hypothetical protein NP_825170.1 4915182 R 227882 CDS NP_825171.1 29830537 1210862 4915779..4916903 1 NC_003155.4 serine/threonine protein kinase 4916903 pkn8 1210862 pkn8 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_825171.1 4915779 D 227882 CDS NP_825172.1 29830538 1214925 4916980..4917876 1 NC_003155.4 hypothetical protein 4917876 1214925 SAV_3995 Streptomyces avermitilis MA-4680 hypothetical protein NP_825172.1 4916980 D 227882 CDS NP_825173.1 29830539 1214926 4918085..4918567 1 NC_003155.4 hypothetical protein 4918567 1214926 SAV_3996 Streptomyces avermitilis MA-4680 hypothetical protein NP_825173.1 4918085 D 227882 CDS NP_825174.1 29830540 1214927 complement(4918858..4919292) 1 NC_003155.4 PF07366: Protein of unknown function (DUF1486); hypothetical protein 4919292 1214927 SAV_3997 Streptomyces avermitilis MA-4680 hypothetical protein NP_825174.1 4918858 R 227882 CDS NP_825175.1 29830541 1214928 4919565..4920089 1 NC_003155.4 hypothetical protein 4920089 1214928 SAV_3998 Streptomyces avermitilis MA-4680 hypothetical protein NP_825175.1 4919565 D 227882 CDS NP_825176.1 29830542 1214929 4920086..4921093 1 NC_003155.4 hypothetical protein 4921093 1214929 SAV_3999 Streptomyces avermitilis MA-4680 hypothetical protein NP_825176.1 4920086 D 227882 CDS NP_825177.1 29830543 1214930 4921426..4921935 1 NC_003155.4 hypothetical protein 4921935 1214930 SAV_4000 Streptomyces avermitilis MA-4680 hypothetical protein NP_825177.1 4921426 D 227882 CDS NP_825178.1 29830544 1214931 complement(4921900..4922481) 1 NC_003155.4 hypothetical protein 4922481 1214931 SAV_4001 Streptomyces avermitilis MA-4680 hypothetical protein NP_825178.1 4921900 R 227882 CDS NP_825179.1 29830545 1214932 complement(4922628..4922972) 1 NC_003155.4 hypothetical protein 4922972 1214932 SAV_4002 Streptomyces avermitilis MA-4680 hypothetical protein NP_825179.1 4922628 R 227882 CDS NP_825180.1 29830546 1214933 4923144..4923956 1 NC_003155.4 AraC family transcription regulator 4923956 1214933 SAV_4003 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_825180.1 4923144 D 227882 CDS NP_825181.1 29830547 1214934 complement(4923935..4925701) 1 NC_003155.4 hypothetical protein 4925701 1214934 SAV_4004 Streptomyces avermitilis MA-4680 hypothetical protein NP_825181.1 4923935 R 227882 CDS NP_825182.1 29830548 1214935 complement(4925852..4926343) 1 NC_003155.4 hypothetical protein 4926343 1214935 SAV_4005 Streptomyces avermitilis MA-4680 hypothetical protein NP_825182.1 4925852 R 227882 CDS NP_825183.1 29830549 1214936 complement(4926336..4927730) 1 NC_003155.4 PF00534: Glycosyl transferases group 1; glycosyl transferase 4927730 glgA1 1214936 glgA1 Streptomyces avermitilis MA-4680 glycosyl transferase NP_825183.1 4926336 R 227882 CDS NP_825184.1 29830550 1214937 4927874..4928692 1 NC_003155.4 hypothetical protein 4928692 1214937 SAV_4007 Streptomyces avermitilis MA-4680 hypothetical protein NP_825184.1 4927874 D 227882 CDS NP_825185.1 29830551 1214938 4928935..4930026 1 NC_003155.4 Seems to have a cleavable N-term signal sequence; NLP/P60-family protein 4930026 1214938 SAV_4008 Streptomyces avermitilis MA-4680 NLP/P60-family protein NP_825185.1 4928935 D 227882 CDS NP_825186.1 29830552 1214939 4930332..4931780 1 NC_003155.4 PF00072: Response regulator receiver domain; magnesium or manganese-dependent protein phosphatase 4931780 prpG1 1214939 prpG1 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_825186.1 4930332 D 227882 CDS NP_825187.1 29830553 1214940 complement(4931839..4932180) 1 NC_003155.4 hypothetical protein 4932180 1214940 SAV_4010 Streptomyces avermitilis MA-4680 hypothetical protein NP_825187.1 4931839 R 227882 CDS NP_825188.1 29830554 1214941 complement(4932294..4932896) 1 NC_003155.4 PF05558: DREPP plasma membrane polypeptide; hypothetical protein 4932896 1214941 SAV_4011 Streptomyces avermitilis MA-4680 hypothetical protein NP_825188.1 4932294 R 227882 CDS NP_825189.1 29830555 1214942 complement(4932975..4933451) 1 NC_003155.4 DNA-binding protein 4933451 1214942 SAV_4012 Streptomyces avermitilis MA-4680 DNA-binding protein NP_825189.1 4932975 R 227882 CDS NP_825190.1 29830556 1214943 4933625..4934038 1 NC_003155.4 integral membrane protein 4934038 1214943 SAV_4013 Streptomyces avermitilis MA-4680 integral membrane protein NP_825190.1 4933625 D 227882 CDS NP_825191.1 29830557 1214944 complement(4934070..4935080) 1 NC_003155.4 PF00724: NADH:flavin oxidoreductase / NADH oxidase family; oxidoreductase 4935080 1214944 SAV_4014 Streptomyces avermitilis MA-4680 oxidoreductase NP_825191.1 4934070 R 227882 CDS NP_825192.1 29830558 1214945 4935246..4935623 1 NC_003155.4 MerR family transcriptional regulator 4935623 1214945 SAV_4015 Streptomyces avermitilis MA-4680 MerR family transcriptional regulator NP_825192.1 4935246 D 227882 CDS NP_825193.1 29830559 1214946 complement(4935669..4937714) 1 NC_003155.4 ATP/GTP-binding protein 4937714 1214946 SAV_4016 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_825193.1 4935669 R 227882 CDS NP_825194.1 29830560 1214947 complement(4937841..4938455) 1 NC_003155.4 TetR family transcriptional regulator 4938455 1214947 SAV_4017 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_825194.1 4937841 R 227882 CDS NP_825195.1 29830561 1214948 4938560..4939528 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 4939528 1214948 SAV_4018 Streptomyces avermitilis MA-4680 dehydrogenase NP_825195.1 4938560 D 227882 CDS NP_825196.1 29830562 1214949 complement(4939587..4941824) 1 NC_003155.4 PF01636: Phosphotransferase enzyme family; hypothetical protein 4941824 1214949 SAV_4019 Streptomyces avermitilis MA-4680 hypothetical protein NP_825196.1 4939587 R 227882 CDS NP_825197.1 29830563 1214950 complement(4942087..4942890) 1 NC_003155.4 PF00702: haloacid dehalogenase-like hydrolase; hydrolase 4942890 1214950 SAV_4020 Streptomyces avermitilis MA-4680 hydrolase NP_825197.1 4942087 R 227882 CDS NP_825198.1 29830564 1214951 complement(4942839..4943717) 1 NC_003155.4 GntR family transcriptional regulator 4943717 1214951 SAV_4021 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_825198.1 4942839 R 227882 CDS NP_825199.1 29830565 1214952 4943871..4944059 1 NC_003155.4 hypothetical protein 4944059 1214952 SAV_4022 Streptomyces avermitilis MA-4680 hypothetical protein NP_825199.1 4943871 D 227882 CDS NP_825200.1 29830566 1214953 complement(4944066..4944983) 1 NC_003155.4 GntR family transcriptional regulator 4944983 1214953 SAV_4023 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_825200.1 4944066 R 227882 CDS NP_825201.1 29830567 1214954 complement(4945345..4946601) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; hypothetical protein 4946601 1214954 SAV_4024 Streptomyces avermitilis MA-4680 hypothetical protein NP_825201.1 4945345 R 227882 CDS NP_825202.1 29830568 1214955 complement(4946725..4947714) 1 NC_003155.4 L-asparaginase II 4947714 1214955 SAV_4025 Streptomyces avermitilis MA-4680 L-asparaginase II NP_825202.1 4946725 R 227882 CDS NP_825203.1 29830569 1210863 complement(4947905..4948501) 1 NC_003155.4 AmfC protein 4948501 amfC 1210863 amfC Streptomyces avermitilis MA-4680 AmfC protein NP_825203.1 4947905 R 227882 CDS NP_825204.1 29830570 1214956 4948672..4949109 1 NC_003155.4 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 4949109 1214956 SAV_4027 Streptomyces avermitilis MA-4680 D-tyrosyl-tRNA(Tyr) deacylase NP_825204.1 4948672 D 227882 CDS NP_825205.1 29830571 1214957 complement(4949159..4950124) 1 NC_003155.4 PF01571: Glycine cleavage T-protein (aminomethyl transferase); hypothetical protein 4950124 1214957 SAV_4028 Streptomyces avermitilis MA-4680 hypothetical protein NP_825205.1 4949159 R 227882 CDS NP_825206.1 29830572 1214958 complement(4950135..4950572) 1 NC_003155.4 iron uptake regulatory protein 4950572 1214958 SAV_4029 Streptomyces avermitilis MA-4680 iron uptake regulatory protein NP_825206.1 4950135 R 227882 CDS NP_825207.1 29830573 1214959 complement(4950649..4951224) 1 NC_003155.4 hypothetical protein 4951224 1214959 SAV_4030 Streptomyces avermitilis MA-4680 hypothetical protein NP_825207.1 4950649 R 227882 CDS NP_825208.1 29830574 1214960 complement(4951514..4952359) 1 NC_003155.4 hypothetical protein 4952359 1214960 SAV_4031 Streptomyces avermitilis MA-4680 hypothetical protein NP_825208.1 4951514 R 227882 CDS NP_825209.1 29830575 1214961 complement(4952356..4953147) 1 NC_003155.4 hypothetical protein 4953147 1214961 SAV_4032 Streptomyces avermitilis MA-4680 hypothetical protein NP_825209.1 4952356 R 227882 CDS NP_825210.1 29830576 1214962 complement(4953222..4954115) 1 NC_003155.4 hypothetical protein 4954115 1214962 SAV_4033 Streptomyces avermitilis MA-4680 hypothetical protein NP_825210.1 4953222 R 227882 CDS NP_825211.1 29830577 1214963 4954208..4954555 1 NC_003155.4 PF02635: DsrE/DsrF-like family; hypothetical protein 4954555 1214963 SAV_4034 Streptomyces avermitilis MA-4680 hypothetical protein NP_825211.1 4954208 D 227882 CDS NP_825212.1 29830578 1214964 complement(4954885..4955196) 1 NC_003155.4 hypothetical protein 4955196 1214964 SAV_4035 Streptomyces avermitilis MA-4680 hypothetical protein NP_825212.1 4954885 R 227882 CDS NP_825213.1 29830579 1214965 complement(4955234..4955521) 1 NC_003155.4 PF07210: Protein of unknown function (DUF1416); hypothetical protein 4955521 1214965 SAV_4036 Streptomyces avermitilis MA-4680 hypothetical protein NP_825213.1 4955234 R 227882 CDS NP_825214.1 29830580 1210864 complement(4955552..4956391) 1 NC_003155.4 thiosulfate sulfurtransferase 4956391 cysA2 1210864 cysA2 Streptomyces avermitilis MA-4680 thiosulfate sulfurtransferase NP_825214.1 4955552 R 227882 CDS NP_825215.1 29830581 1214966 complement(4956838..4957581) 1 NC_003155.4 hypothetical protein 4957581 1214966 SAV_4038 Streptomyces avermitilis MA-4680 hypothetical protein NP_825215.1 4956838 R 227882 CDS NP_825216.1 29830582 1214967 complement(4957811..4959025) 1 NC_003155.4 integral membrane protein 4959025 1214967 SAV_4039 Streptomyces avermitilis MA-4680 integral membrane protein NP_825216.1 4957811 R 227882 CDS NP_825217.1 29830583 1210865 complement(4959022..4959276) 1 NC_003155.4 molybdopterin converting factor 4959276 moaD 1210865 moaD Streptomyces avermitilis MA-4680 molybdopterin converting factor NP_825217.1 4959022 R 227882 CDS NP_825218.1 29830584 1214968 complement(4959369..4960262) 1 NC_003155.4 PF00326: Prolyl oligopeptidase family; hydrolase 4960262 1214968 SAV_4041 Streptomyces avermitilis MA-4680 hydrolase NP_825218.1 4959369 R 227882 CDS NP_825219.1 29830585 1214969 4960555..4961364 1 NC_003155.4 two-component system response regulator 4961364 1214969 SAV_4042 Streptomyces avermitilis MA-4680 two-component system response regulator NP_825219.1 4960555 D 227882 CDS NP_825220.1 29830586 1214970 4961428..4962471 1 NC_003155.4 LacI family transcriptional regulator 4962471 1214970 SAV_4043 Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_825220.1 4961428 D 227882 CDS NP_825221.1 29830587 1214971 complement(4962728..4964491) 1 NC_003155.4 PF00089: Trypsin; trypsin-like protease 4964491 1214971 SAV_4044 Streptomyces avermitilis MA-4680 trypsin-like protease NP_825221.1 4962728 R 227882 CDS NP_825222.1 29830588 1214972 4964900..4966135 1 NC_003155.4 PF00089: Trypsin; serine protease 4966135 1214972 SAV_4045 Streptomyces avermitilis MA-4680 serine protease NP_825222.1 4964900 D 227882 CDS NP_825223.1 29830589 1214973 4966152..4966406 1 NC_003155.4 hypothetical protein 4966406 1214973 SAV_4046 Streptomyces avermitilis MA-4680 hypothetical protein NP_825223.1 4966152 D 227882 CDS NP_825224.1 29830590 1214974 4966793..4967524 1 NC_003155.4 two-component system response regulator 4967524 1214974 SAV_4047 Streptomyces avermitilis MA-4680 two-component system response regulator NP_825224.1 4966793 D 227882 CDS NP_825225.1 29830591 1214975 4967521..4969005 1 NC_003155.4 two-component system sensor kinase 4969005 1214975 SAV_4048 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_825225.1 4967521 D 227882 CDS NP_825226.1 29830592 1214976 complement(4969010..4969225) 1 NC_003155.4 regulatory protein 4969225 1214976 SAV_4049 Streptomyces avermitilis MA-4680 regulatory protein NP_825226.1 4969010 R 227882 CDS NP_825227.1 29830593 1214977 complement(4969213..4970046) 1 NC_003155.4 DNA-binding protein 4970046 1214977 SAV_4050 Streptomyces avermitilis MA-4680 DNA-binding protein NP_825227.1 4969213 R 227882 CDS NP_825228.1 29830594 1214978 4970507..4970803 1 NC_003155.4 hypothetical protein 4970803 1214978 SAV_4051 Streptomyces avermitilis MA-4680 hypothetical protein NP_825228.1 4970507 D 227882 CDS NP_825229.1 29830595 1214979 complement(4970862..4972535) 1 NC_003155.4 PF03023: MviN-like protein; hypothetical protein 4972535 1214979 SAV_4052 Streptomyces avermitilis MA-4680 hypothetical protein NP_825229.1 4970862 R 227882 CDS NP_825230.1 29830596 1214980 complement(4972612..4974417) 1 NC_003155.4 ABC transporter ATP-binding protein 4974417 1214980 SAV_4053 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_825230.1 4972612 R 227882 CDS NP_825231.1 29830597 1214981 4974504..4974677 1 NC_003155.4 hypothetical protein 4974677 1214981 SAV_4054 Streptomyces avermitilis MA-4680 hypothetical protein NP_825231.1 4974504 D 227882 CDS NP_825232.1 29830598 1214982 complement(4974733..4974867) 1 NC_003155.4 hypothetical protein 4974867 1214982 SAV_4055 Streptomyces avermitilis MA-4680 hypothetical protein NP_825232.1 4974733 R 227882 CDS NP_825233.1 29830599 1214983 complement(4975110..4976189) 1 NC_003155.4 hypothetical protein 4976189 1214983 SAV_4056 Streptomyces avermitilis MA-4680 hypothetical protein NP_825233.1 4975110 R 227882 CDS NP_825234.1 29830600 1214984 complement(4976461..4978272) 1 NC_003155.4 5'-nucleotidase 4978272 1214984 SAV_4057 Streptomyces avermitilis MA-4680 5'-nucleotidase NP_825234.1 4976461 R 227882 CDS NP_825235.1 29830601 1214985 4978424..4979350 1 NC_003155.4 mycothiol biosynthesis; acetyltransferase 4979350 mshD 1214985 mshD Streptomyces avermitilis MA-4680 acetyltransferase NP_825235.1 4978424 D 227882 CDS NP_825236.1 29830602 1214986 complement(4979424..4980002) 1 NC_003155.4 hypothetical protein 4980002 1214986 SAV_4059 Streptomyces avermitilis MA-4680 hypothetical protein NP_825236.1 4979424 R 227882 CDS NP_825237.1 29830603 1214987 complement(4980098..4981669) 1 NC_003155.4 hypothetical protein 4981669 1214987 SAV_4060 Streptomyces avermitilis MA-4680 hypothetical protein NP_825237.1 4980098 R 227882 CDS NP_825238.1 29830604 1214988 complement(4981666..4982532) 1 NC_003155.4 ABC transporter ATP-binding protein 4982532 1214988 SAV_4061 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_825238.1 4981666 R 227882 CDS NP_825239.1 29830605 1214989 complement(4982624..4982830) 1 NC_003155.4 hypothetical protein 4982830 1214989 SAV_4062 Streptomyces avermitilis MA-4680 hypothetical protein NP_825239.1 4982624 R 227882 CDS NP_825240.1 29830606 1214990 complement(4982830..4983687) 1 NC_003155.4 integral membrane protein 4983687 1214990 SAV_4063 Streptomyces avermitilis MA-4680 integral membrane protein NP_825240.1 4982830 R 227882 CDS NP_825241.1 29830607 1210866 complement(4983684..4984223) 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 4984223 sig33 1210866 sig33 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_825241.1 4983684 R 227882 CDS NP_825242.1 29830608 1214991 4984323..4984721 1 NC_003155.4 GntR family transcriptional regulator 4984721 1214991 SAV_4065 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_825242.1 4984323 D 227882 CDS NP_825243.1 29830609 1214992 4984718..4985635 1 NC_003155.4 ABC transporter ATP-binding protein 4985635 1214992 SAV_4066 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_825243.1 4984718 D 227882 CDS NP_825244.1 29830610 1214993 4985632..4986573 1 NC_003155.4 hypothetical protein 4986573 1214993 SAV_4067 Streptomyces avermitilis MA-4680 hypothetical protein NP_825244.1 4985632 D 227882 CDS NP_825245.1 29830611 1214994 4986585..4987538 1 NC_003155.4 hypothetical protein 4987538 1214994 SAV_4068 Streptomyces avermitilis MA-4680 hypothetical protein NP_825245.1 4986585 D 227882 CDS NP_825246.1 29830612 1210867 4987758..4990112 1 NC_003155.4 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 4990112 ppk 1210867 ppk Streptomyces avermitilis MA-4680 polyphosphate kinase NP_825246.1 4987758 D 227882 CDS NP_825247.1 29830613 1214995 4990093..4991175 1 NC_003155.4 hypothetical protein 4991175 1214995 SAV_4070 Streptomyces avermitilis MA-4680 hypothetical protein NP_825247.1 4990093 D 227882 CDS NP_825248.1 29830614 1214996 4991242..4991655 1 NC_003155.4 PF00293: NUDIX domain; hypothetical protein 4991655 1214996 SAV_4071 Streptomyces avermitilis MA-4680 hypothetical protein NP_825248.1 4991242 D 227882 CDS NP_825249.1 29830615 1210868 4991906..4993012 1 NC_003155.4 phosphate-binding protein precursor 4993012 pstS 1210868 pstS Streptomyces avermitilis MA-4680 phosphate-binding protein precursor NP_825249.1 4991906 D 227882 CDS NP_825250.1 29830616 1210869 4993113..4994120 1 NC_003155.4 PF00528: Binding-protein-dependent transport system inner membrane component; phosphate ABC transporter permease 4994120 pstC 1210869 pstC Streptomyces avermitilis MA-4680 phosphate ABC transporter permease NP_825250.1 4993113 D 227882 CDS NP_825251.1 29830617 1210870 4994117..4995178 1 NC_003155.4 phosphate ABC transporter permease 4995178 pstA 1210870 pstA Streptomyces avermitilis MA-4680 phosphate ABC transporter permease NP_825251.1 4994117 D 227882 CDS NP_825252.1 29830618 1210871 4995253..4996029 1 NC_003155.4 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 4996029 pstB 1210871 pstB Streptomyces avermitilis MA-4680 phosphate transporter ATP-binding protein NP_825252.1 4995253 D 227882 CDS NP_825253.1 29830619 1210872 complement(4996433..4997431) 1 NC_003155.4 low-affinity inorganic phosphate transporter 4997431 pitH1 1210872 pitH1 Streptomyces avermitilis MA-4680 low-affinity inorganic phosphate transporter NP_825253.1 4996433 R 227882 CDS NP_825254.1 29830620 1214997 complement(4997439..4998059) 1 NC_003155.4 Pit accessory protein 4998059 1214997 SAV_4077 Streptomyces avermitilis MA-4680 Pit accessory protein NP_825254.1 4997439 R 227882 CDS NP_825255.1 29830621 1214998 4998272..4998628 1 NC_003155.4 PF02583: Uncharacterised BCR, COG1937; hypothetical protein 4998628 1214998 SAV_4078 Streptomyces avermitilis MA-4680 hypothetical protein NP_825255.1 4998272 D 227882 CDS NP_825256.1 29830622 1214999 complement(4998730..4998918) 1 NC_003155.4 hypothetical protein 4998918 1214999 SAV_4079 Streptomyces avermitilis MA-4680 hypothetical protein NP_825256.1 4998730 R 227882 CDS NP_825257.1 29830623 1215000 complement(4999070..4999903) 1 NC_003155.4 lipoprotein 4999903 1215000 SAV_4080 Streptomyces avermitilis MA-4680 lipoprotein NP_825257.1 4999070 R 227882 CDS NP_825258.1 29830624 1215001 5000470..5002047 1 NC_003155.4 PF01565: FAD binding domain; lipoprotein 5002047 1215001 SAV_4081 Streptomyces avermitilis MA-4680 lipoprotein NP_825258.1 5000470 D 227882 CDS NP_825259.1 29830625 1215002 complement(5002135..5002833) 1 NC_003155.4 PF01569: PAP2 superfamily; integral membrane protein 5002833 1215002 SAV_4082 Streptomyces avermitilis MA-4680 integral membrane protein NP_825259.1 5002135 R 227882 CDS NP_825260.1 29830626 1215003 complement(5003027..5004034) 1 NC_003155.4 PF00877: NlpC/P60 family; transglycosylase 5004034 1215003 SAV_4083 Streptomyces avermitilis MA-4680 transglycosylase NP_825260.1 5003027 R 227882 CDS NP_825261.1 29830627 1210873 complement(5004166..5005890) 1 NC_003155.4 serine/threonine protein kinase 5005890 pkn9 1210873 pkn9 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_825261.1 5004166 R 227882 CDS NP_825262.1 29830628 1215004 complement(5005913..5006737) 1 NC_003155.4 PF00089: Trypsin; hypothetical protein 5006737 1215004 SAV_4085 Streptomyces avermitilis MA-4680 hypothetical protein NP_825262.1 5005913 R 227882 CDS NP_825263.1 29830629 1215005 complement(5006750..5007181) 1 NC_003155.4 regulatory protein 5007181 1215005 SAV_4086 Streptomyces avermitilis MA-4680 regulatory protein NP_825263.1 5006750 R 227882 CDS NP_825264.1 29830630 1215006 5007367..5008239 1 NC_003155.4 DNA-binding protein 5008239 1215006 SAV_4087 Streptomyces avermitilis MA-4680 DNA-binding protein NP_825264.1 5007367 D 227882 CDS NP_825265.1 29830631 1215007 5008236..5008451 1 NC_003155.4 PF04149: Domain of unknown function (DUF397); hypothetical protein 5008451 1215007 SAV_4088 Streptomyces avermitilis MA-4680 hypothetical protein NP_825265.1 5008236 D 227882 CDS NP_825266.1 29830632 1215008 5008444..5008689 1 NC_003155.4 PF04149: Domain of unknown function (DUF397); hypothetical protein 5008689 1215008 SAV_4089 Streptomyces avermitilis MA-4680 hypothetical protein NP_825266.1 5008444 D 227882 CDS NP_825267.1 29830633 1215009 complement(5008711..5009085) 1 NC_003155.4 hypothetical protein 5009085 1215009 SAV_4090 Streptomyces avermitilis MA-4680 hypothetical protein NP_825267.1 5008711 R 227882 CDS NP_825268.1 29830634 1215010 complement(5009394..5009873) 1 NC_003155.4 hypothetical protein 5009873 1215010 SAV_4091 Streptomyces avermitilis MA-4680 hypothetical protein NP_825268.1 5009394 R 227882 CDS NP_825269.1 29830635 1215011 complement(5009903..5010520) 1 NC_003155.4 PF00805: Pentapeptide repeats (8 copies); hypothetical protein 5010520 1215011 SAV_4092 Streptomyces avermitilis MA-4680 hypothetical protein NP_825269.1 5009903 R 227882 CDS NP_825270.1 29830636 1215012 complement(5010521..5011432) 1 NC_003155.4 hypothetical protein 5011432 1215012 SAV_4093 Streptomyces avermitilis MA-4680 hypothetical protein NP_825270.1 5010521 R 227882 CDS NP_825271.1 29830637 1215013 complement(5011670..5013994) 1 NC_003155.4 hypothetical protein 5013994 1215013 SAV_4094 Streptomyces avermitilis MA-4680 hypothetical protein NP_825271.1 5011670 R 227882 CDS NP_825272.1 29830638 1215014 complement(5013991..5014383) 1 NC_003155.4 hypothetical protein 5014383 1215014 SAV_4095 Streptomyces avermitilis MA-4680 hypothetical protein NP_825272.1 5013991 R 227882 CDS NP_825273.1 29830639 1215015 complement(5014424..5014741) 1 NC_003155.4 hypothetical protein 5014741 1215015 SAV_4096 Streptomyces avermitilis MA-4680 hypothetical protein NP_825273.1 5014424 R 227882 CDS NP_825274.1 29830640 1215016 complement(5014792..5015124) 1 NC_003155.4 hypothetical protein 5015124 1215016 SAV_4097 Streptomyces avermitilis MA-4680 hypothetical protein NP_825274.1 5014792 R 227882 CDS NP_825275.1 29830641 1215017 5015883..5016191 1 NC_003155.4 integral membrane protein 5016191 1215017 SAV_4098 Streptomyces avermitilis MA-4680 integral membrane protein NP_825275.1 5015883 D 227882 CDS NP_825276.1 29830642 1215018 5016402..5017253 1 NC_003155.4 integral membrane protein 5017253 1215018 SAV_4099 Streptomyces avermitilis MA-4680 integral membrane protein NP_825276.1 5016402 D 227882 CDS NP_825277.1 29830643 1215019 5017243..5018577 1 NC_003155.4 integral membrane protein 5018577 1215019 SAV_4100 Streptomyces avermitilis MA-4680 integral membrane protein NP_825277.1 5017243 D 227882 CDS NP_825278.1 29830644 1215020 5018592..5020133 1 NC_003155.4 hypothetical protein 5020133 1215020 SAV_4101 Streptomyces avermitilis MA-4680 hypothetical protein NP_825278.1 5018592 D 227882 CDS NP_825279.1 29830645 1215021 5020173..5021603 1 NC_003155.4 ATP/GTP-binding protein 5021603 1215021 SAV_4102 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_825279.1 5020173 D 227882 CDS NP_825280.1 29830646 1215022 5021723..5023351 1 NC_003155.4 hypothetical protein 5023351 1215022 SAV_4103 Streptomyces avermitilis MA-4680 hypothetical protein NP_825280.1 5021723 D 227882 CDS NP_825281.1 29830647 1215023 complement(5023429..5023974) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 5023974 1215023 SAV_4104 Streptomyces avermitilis MA-4680 acetyltransferase NP_825281.1 5023429 R 227882 CDS NP_825282.1 29830648 1215024 complement(5029929..5030477) 1 NC_003155.4 MarR family transcriptional regulator 5030477 1215024 SAV_4105 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_825282.1 5029929 R 227882 CDS NP_825283.1 29830649 1215025 5030639..5031910 1 NC_003155.4 PF07690: Major Facilitator Superfamily; hypothetical protein 5031910 1215025 SAV_4106 Streptomyces avermitilis MA-4680 hypothetical protein NP_825283.1 5030639 D 227882 CDS NP_825284.1 29830650 1215026 complement(5031992..5032807) 1 NC_003155.4 methyltransferase 5032807 1215026 SAV_4107 Streptomyces avermitilis MA-4680 methyltransferase NP_825284.1 5031992 R 227882 CDS NP_825285.1 29830651 1215027 complement(5032918..5034567) 1 NC_003155.4 PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; magnesium or manganese-dependent protein phosphatase 5034567 prpI3 1215027 prpI3 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_825285.1 5032918 R 227882 CDS NP_825286.1 29830652 1215028 complement(5034691..5036010) 1 NC_003155.4 PF00070: Pyridine nucleotide-disulphide oxidoreductase; NADH dehydrogenase 5036010 ndh3 1215028 ndh3 Streptomyces avermitilis MA-4680 NADH dehydrogenase NP_825286.1 5034691 R 227882 CDS NP_825287.1 29830653 1215029 5036435..5037193 1 NC_003155.4 TetR family transcriptional regulator 5037193 1215029 SAV_4110 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_825287.1 5036435 D 227882 CDS NP_825288.1 29830654 1215030 complement(5037479..5040880) 1 NC_003155.4 transcriptional regulator 5040880 1215030 SAV_4111 Streptomyces avermitilis MA-4680 transcriptional regulator NP_825288.1 5037479 R 227882 CDS NP_825289.1 29830655 1215031 complement(5041026..5042774) 1 NC_003155.4 PF00733: Asparagine synthase; hypothetical protein 5042774 1215031 SAV_4112 Streptomyces avermitilis MA-4680 hypothetical protein NP_825289.1 5041026 R 227882 CDS NP_825290.1 29830656 1210877 5043789..5045213 1 NC_003155.4 PF06036: Streptomyces protein of unknown function (DUF921); sporulation associated protein 5045213 sap 1210877 sap Streptomyces avermitilis MA-4680 sporulation associated protein NP_825290.1 5043789 D 227882 CDS NP_825291.1 29830657 1215032 5045350..5046591 1 NC_003155.4 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate; hydroxyglutarate oxidase 5046591 1215032 SAV_4114 Streptomyces avermitilis MA-4680 hydroxyglutarate oxidase NP_825291.1 5045350 D 227882 CDS NP_825292.1 29830658 1215033 5046990..5047862 1 NC_003155.4 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 5047862 trmB 1215033 trmB Streptomyces avermitilis MA-4680 tRNA (guanine-N(7)-)-methyltransferase NP_825292.1 5046990 D 227882 CDS NP_825293.1 29830659 1215034 5047927..5049288 1 NC_003155.4 hypothetical protein 5049288 1215034 SAV_4116 Streptomyces avermitilis MA-4680 hypothetical protein NP_825293.1 5047927 D 227882 CDS NP_825294.1 29830660 1215035 complement(5049328..5050272) 1 NC_003155.4 PF00248: Aldo/keto reductase family; oxidoreductase 5050272 1215035 SAV_4117 Streptomyces avermitilis MA-4680 oxidoreductase NP_825294.1 5049328 R 227882 CDS NP_825295.1 29830661 1215036 complement(5050422..5051465) 1 NC_003155.4 PF01551: Peptidase family M23; peptidase 5051465 1215036 SAV_4118 Streptomyces avermitilis MA-4680 peptidase NP_825295.1 5050422 R 227882 CDS NP_825296.1 29830662 1210879 complement(5052156..5053286) 1 NC_003155.4 riboflavin/cytosine deaminase 5053286 ribG 1210879 ribG Streptomyces avermitilis MA-4680 riboflavin/cytosine deaminase NP_825296.1 5052156 R 227882 CDS NP_825297.1 29830663 1215037 5053338..5053838 1 NC_003155.4 MarR family transcriptional regulator 5053838 1215037 SAV_4120 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_825297.1 5053338 D 227882 CDS NP_825298.1 29830664 1210880 5054141..5054848 1 NC_003155.4 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 5054848 ribA 1210880 ribA Streptomyces avermitilis MA-4680 GTP cyclohydrolase II NP_825298.1 5054141 D 227882 CDS NP_825299.1 29830665 1215038 complement(5055705..5057240) 1 NC_003155.4 PF00324: Amino acid permease; amino acid permease 5057240 1215038 SAV_4122 Streptomyces avermitilis MA-4680 amino acid permease NP_825299.1 5055705 R 227882 CDS NP_825300.1 29830666 1215039 complement(5057467..5059710) 1 NC_003155.4 PF00270: DEAD/DEAH box helicase; ATP-dependent RNA helicase 5059710 1215039 SAV_4123 Streptomyces avermitilis MA-4680 ATP-dependent RNA helicase NP_825300.1 5057467 R 227882 CDS NP_825301.1 29830667 1215040 complement(5060143..5060583) 1 NC_003155.4 hypothetical protein 5060583 1215040 SAV_4124 Streptomyces avermitilis MA-4680 hypothetical protein NP_825301.1 5060143 R 227882 CDS NP_825302.1 29830668 1215041 complement(5060838..5061188) 1 NC_003155.4 PF06262: Domain of unknown function (DUF1025); hypothetical protein 5061188 1215041 SAV_4125 Streptomyces avermitilis MA-4680 hypothetical protein NP_825302.1 5060838 R 227882 CDS NP_825303.1 29830669 1215042 5061300..5062937 1 NC_003155.4 PF00149: Calcineurin-like phosphoesterase; hypothetical protein 5062937 1215042 SAV_4126 Streptomyces avermitilis MA-4680 hypothetical protein NP_825303.1 5061300 D 227882 CDS NP_825304.1 29830670 1215043 5063566..5063889 1 NC_003155.4 hypothetical protein 5063889 1215043 SAV_4127 Streptomyces avermitilis MA-4680 hypothetical protein NP_825304.1 5063566 D 227882 CDS NP_825305.1 29830671 1210885 5064051..5068028 1 NC_003155.4 ATP-dependent helicase 5068028 hrpA 1210885 hrpA Streptomyces avermitilis MA-4680 ATP-dependent helicase NP_825305.1 5064051 D 227882 CDS NP_825306.1 29830672 1215044 5068384..5068575 1 NC_003155.4 hypothetical protein 5068575 1215044 SAV_4129 Streptomyces avermitilis MA-4680 hypothetical protein NP_825306.1 5068384 D 227882 CDS NP_825307.1 29830673 1215045 complement(5069093..5069299) 1 NC_003155.4 MerR family transcriptional regulator 5069299 1215045 SAV_4130 Streptomyces avermitilis MA-4680 MerR family transcriptional regulator NP_825307.1 5069093 R 227882 CDS NP_825308.1 29830674 1215046 complement(5069900..5070745) 1 NC_003155.4 hypothetical protein 5070745 1215046 SAV_4131 Streptomyces avermitilis MA-4680 hypothetical protein NP_825308.1 5069900 R 227882 CDS NP_825309.1 29830675 1210887 5070973..5072058 1 NC_003155.4 valine dehydrogenase (NADP+) 5072058 vdh 1210887 vdh Streptomyces avermitilis MA-4680 valine dehydrogenase (NADP+) NP_825309.1 5070973 D 227882 CDS NP_825310.1 29830676 1215047 5072358..5072609 1 NC_003155.4 hypothetical protein 5072609 1215047 SAV_4133 Streptomyces avermitilis MA-4680 hypothetical protein NP_825310.1 5072358 D 227882 CDS NP_825311.1 29830677 1210888 complement(5072757..5073851) 1 NC_003155.4 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 5073851 purM 1210888 purM Streptomyces avermitilis MA-4680 phosphoribosylaminoimidazole synthetase NP_825311.1 5072757 R 227882 CDS NP_825312.1 29830678 1210889 complement(5073884..5075464) 1 NC_003155.4 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 5075464 purF 1210889 purF Streptomyces avermitilis MA-4680 amidophosphoribosyltransferase NP_825312.1 5073884 R 227882 CDS NP_825313.1 29830679 1215048 complement(5075496..5076371) 1 NC_003155.4 PF03724: Domain of unknown function (306); hypothetical protein 5076371 1215048 SAV_4136 Streptomyces avermitilis MA-4680 hypothetical protein NP_825313.1 5075496 R 227882 CDS NP_825314.1 29830680 1215049 complement(5076528..5077325) 1 NC_003155.4 hypothetical protein 5077325 1215049 SAV_4137 Streptomyces avermitilis MA-4680 hypothetical protein NP_825314.1 5076528 R 227882 CDS NP_825315.1 29830681 1210890 complement(5077540..5079798) 1 NC_003155.4 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase II 5079798 purL 1210890 purL Streptomyces avermitilis MA-4680 phosphoribosylformylglycinamidine synthase II NP_825315.1 5077540 R 227882 CDS NP_825316.1 29830682 1210891 complement(5079795..5080499) 1 NC_003155.4 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase I 5080499 purQ 1210891 purQ Streptomyces avermitilis MA-4680 phosphoribosylformylglycinamidine synthase I NP_825316.1 5079795 R 227882 CDS NP_825317.1 29830683 1215050 complement(5080496..5080762) 1 NC_003155.4 With PurL and PurQ catalyzes the conversion of formylglycinamide ribonucleotide, ATP, and glutamine to formylglycinamidine ribonucleotide, ADP, and glutamate in the fourth step of the purine biosynthetic pathway; phosphoribosylformylglycinamidine synthase subunit PurS 5080762 purS 1215050 purS Streptomyces avermitilis MA-4680 phosphoribosylformylglycinamidine synthase subunit PurS NP_825317.1 5080496 R 227882 CDS NP_825318.1 29830684 1215051 5081122..5081439 1 NC_003155.4 Lsr2-like protein 5081439 1215051 SAV_4141 Streptomyces avermitilis MA-4680 Lsr2-like protein NP_825318.1 5081122 D 227882 CDS NP_825319.1 29830685 1215052 5082037..5083050 1 NC_003155.4 ABC transporter ATP-binding protein 5083050 1215052 SAV_4142 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_825319.1 5082037 D 227882 CDS NP_825320.1 29830686 1215053 5083047..5083826 1 NC_003155.4 ABC transporter permease 5083826 1215053 SAV_4143 Streptomyces avermitilis MA-4680 ABC transporter permease NP_825320.1 5083047 D 227882 CDS NP_825321.1 29830687 1215054 5083855..5085111 1 NC_003155.4 two-component system sensor kinase 5085111 1215054 SAV_4144 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_825321.1 5083855 D 227882 CDS NP_825322.1 29830688 1215055 5085153..5085755 1 NC_003155.4 two-component system response regulator 5085755 1215055 SAV_4145 Streptomyces avermitilis MA-4680 two-component system response regulator NP_825322.1 5085153 D 227882 CDS NP_825323.1 29830689 1210894 complement(5085906..5086805) 1 NC_003155.4 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 5086805 hemH 1210894 hemH Streptomyces avermitilis MA-4680 phosphoribosylaminoimidazole-succinocarboxamide synthase NP_825323.1 5085906 R 227882 CDS NP_825324.1 29830690 1215056 complement(5087009..5088553) 1 NC_003155.4 hypothetical protein 5088553 1215056 SAV_4147 Streptomyces avermitilis MA-4680 hypothetical protein NP_825324.1 5087009 R 227882 CDS NP_825325.1 29830691 1215057 complement(5088716..5090698) 1 NC_003155.4 similar to phage coat protein; hypothetical protein 5090698 1215057 SAV_4148 Streptomyces avermitilis MA-4680 hypothetical protein NP_825325.1 5088716 R 227882 CDS NP_825326.1 29830692 1210895 complement(5091096..5092349) 1 NC_003155.4 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 5092349 purD 1210895 purD Streptomyces avermitilis MA-4680 phosphoribosylamine--glycine ligase NP_825326.1 5091096 R 227882 CDS NP_825327.1 29830693 1210896 complement(5092430..5094970) 1 NC_003155.4 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 5094970 dnaZX 1210896 dnaZX Streptomyces avermitilis MA-4680 DNA polymerase III subunits gamma and tau NP_825327.1 5092430 R 227882 CDS NP_825328.1 29830694 1215058 5095612..5098305 1 NC_003155.4 PF01590: GAF domain; magnesium or manganese-dependent protein phosphatase 5098305 prpC6 1215058 prpC6 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_825328.1 5095612 D 227882 CDS NP_825329.1 29830695 1215059 5098501..5100099 1 NC_003155.4 PF01433: Peptidase family M1; metallopeptidase 5100099 1215059 SAV_4152 Streptomyces avermitilis MA-4680 metallopeptidase NP_825329.1 5098501 D 227882 CDS NP_825330.1 29830696 1215060 5100404..5102419 1 NC_003155.4 amidase 5102419 1215060 SAV_4153 Streptomyces avermitilis MA-4680 amidase NP_825330.1 5100404 D 227882 CDS NP_825331.1 29830697 1210898 5102772..5102975 1 NC_003155.4 cold shock protein 5102975 cspD3 1210898 cspD3 Streptomyces avermitilis MA-4680 cold shock protein NP_825331.1 5102772 D 227882 CDS NP_825332.1 29830698 1215061 5103407..5104915 1 NC_003155.4 PF00270: DEAD/DEAH box helicase; ATP-dependent RNA helicase 5104915 1215061 SAV_4155 Streptomyces avermitilis MA-4680 ATP-dependent RNA helicase NP_825332.1 5103407 D 227882 CDS NP_825333.1 29830699 1215062 5105027..5105323 1 NC_003155.4 PF00571: CBS domain; hypothetical protein 5105323 1215062 SAV_4156 Streptomyces avermitilis MA-4680 hypothetical protein NP_825333.1 5105027 D 227882 CDS NP_825334.1 29830700 1215063 5105369..5105683 1 NC_003155.4 hypothetical protein 5105683 1215063 SAV_4157 Streptomyces avermitilis MA-4680 hypothetical protein NP_825334.1 5105369 D 227882 CDS NP_825335.1 29830701 1215064 complement(5105820..5107415) 1 NC_003155.4 two-component system sensor kinase 5107415 1215064 SAV_4158 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_825335.1 5105820 R 227882 CDS NP_825336.1 29830702 1215065 complement(5107519..5108241) 1 NC_003155.4 two-component system response regulator 5108241 1215065 SAV_4159 Streptomyces avermitilis MA-4680 two-component system response regulator NP_825336.1 5107519 R 227882 CDS NP_825337.1 29830703 1215066 5108379..5109572 1 NC_003155.4 hypothetical protein 5109572 1215066 SAV_4160 Streptomyces avermitilis MA-4680 hypothetical protein NP_825337.1 5108379 D 227882 CDS NP_825338.1 29830704 1215067 5109633..5110922 1 NC_003155.4 hypothetical protein 5110922 1215067 SAV_4161 Streptomyces avermitilis MA-4680 hypothetical protein NP_825338.1 5109633 D 227882 CDS NP_825339.1 29830705 1215068 complement(5111059..5112135) 1 NC_003155.4 hypothetical protein 5112135 1215068 SAV_4162 Streptomyces avermitilis MA-4680 hypothetical protein NP_825339.1 5111059 R 227882 CDS NP_825340.1 29830706 1215069 complement(5112227..5113102) 1 NC_003155.4 hypothetical protein 5113102 1215069 SAV_4163 Streptomyces avermitilis MA-4680 hypothetical protein NP_825340.1 5112227 R 227882 CDS NP_825341.1 29830707 1215070 complement(5113132..5114418) 1 NC_003155.4 glycine-rich protein; hypothetical protein 5114418 1215070 SAV_4164 Streptomyces avermitilis MA-4680 hypothetical protein NP_825341.1 5113132 R 227882 CDS NP_825342.1 29830708 1215071 5114915..5115271 1 NC_003155.4 PF05239: PRC-barrel domain; hypothetical protein 5115271 1215071 SAV_4165 Streptomyces avermitilis MA-4680 hypothetical protein NP_825342.1 5114915 D 227882 CDS NP_825343.1 29830709 1215072 complement(5115396..5117165) 1 NC_003155.4 PF04234: Copper resistance protein CopC; hypothetical protein 5117165 1215072 SAV_4166 Streptomyces avermitilis MA-4680 hypothetical protein NP_825343.1 5115396 R 227882 CDS NP_825344.1 29830710 1215073 complement(5117411..5118334) 1 NC_003155.4 frameshift; dehydrogenase 5118334 1215073 SAV_4168 Streptomyces avermitilis MA-4680 dehydrogenase NP_825344.1 5117411 R 227882 CDS NP_825345.1 29830711 1215074 complement(5117503..5117910) 1 NC_003155.4 frameshift, PF00106: short chain dehydrogenase; dehydrogenase 5117910 1215074 SAV_4167 Streptomyces avermitilis MA-4680 dehydrogenase NP_825345.1 5117503 R 227882 CDS NP_825346.1 29830712 1215075 complement(5118322..5118801) 1 NC_003155.4 PF06172: Protein of unknown function (DUF985); hypothetical protein 5118801 1215075 SAV_4169 Streptomyces avermitilis MA-4680 hypothetical protein NP_825346.1 5118322 R 227882 CDS NP_825347.1 29830713 1215076 complement(5118812..5119426) 1 NC_003155.4 alcB homolog; aceytltranferase 5119426 1215076 SAV_4170 Streptomyces avermitilis MA-4680 aceytltranferase NP_825347.1 5118812 R 227882 CDS NP_825348.1 29830714 1215077 complement(5119416..5121623) 1 NC_003155.4 PF01804: Penicillin amidase; penicillin acylase 5121623 pacB2 1215077 pacB2 Streptomyces avermitilis MA-4680 penicillin acylase NP_825348.1 5119416 R 227882 CDS NP_825349.1 29830715 1215078 5121847..5122473 1 NC_003155.4 PF03729: Short repeat of unknown function (DUF308); hypothetical protein 5122473 1215078 SAV_4172 Streptomyces avermitilis MA-4680 hypothetical protein NP_825349.1 5121847 D 227882 CDS NP_825350.1 29830716 1215079 5122539..5123207 1 NC_003155.4 PF03729: Short repeat of unknown function (DUF308); hypothetical protein 5123207 1215079 SAV_4173 Streptomyces avermitilis MA-4680 hypothetical protein NP_825350.1 5122539 D 227882 CDS NP_825351.1 29830717 1215080 5123221..5123640 1 NC_003155.4 hypothetical protein 5123640 1215080 SAV_4174 Streptomyces avermitilis MA-4680 hypothetical protein NP_825351.1 5123221 D 227882 CDS NP_825352.1 29830718 1215081 complement(5123892..5125466) 1 NC_003155.4 PF05872: Bacterial protein of unknown function (DUF853); hypothetical protein 5125466 1215081 SAV_4175 Streptomyces avermitilis MA-4680 hypothetical protein NP_825352.1 5123892 R 227882 CDS NP_825353.1 29830719 1215082 5125590..5125886 1 NC_003155.4 hypothetical protein 5125886 1215082 SAV_4176 Streptomyces avermitilis MA-4680 hypothetical protein NP_825353.1 5125590 D 227882 CDS NP_825354.1 29830720 1215083 5126033..5126662 1 NC_003155.4 hypothetical protein 5126662 1215083 SAV_4177 Streptomyces avermitilis MA-4680 hypothetical protein NP_825354.1 5126033 D 227882 CDS NP_825355.1 29830721 1210899 complement(5126876..5127511) 1 NC_003155.4 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 5127511 upp 1210899 upp Streptomyces avermitilis MA-4680 uracil phosphoribosyltransferase NP_825355.1 5126876 R 227882 CDS NP_825356.1 29830722 1215084 5128249..5128800 1 NC_003155.4 hypothetical protein 5128800 1215084 SAV_4179 Streptomyces avermitilis MA-4680 hypothetical protein NP_825356.1 5128249 D 227882 CDS NP_825357.1 29830723 1215085 5129204..5129632 1 NC_003155.4 PF00383: Cytidine and deoxycytidylate deaminase zinc-binding region; cytidine/deoxycytidine deaminase 5129632 cdd3 1215085 cdd3 Streptomyces avermitilis MA-4680 cytidine/deoxycytidine deaminase NP_825357.1 5129204 D 227882 CDS NP_825358.1 29830724 1215086 complement(5130705..5131628) 1 NC_003155.4 phage integrase near tRNA gene, PF00589: Phage integrase family; integrase/recombinase 5131628 int10 1215086 int10 Streptomyces avermitilis MA-4680 integrase/recombinase NP_825358.1 5130705 R 227882 CDS NP_825359.1 29830725 1215087 5131802..5132035 1 NC_003155.4 hypothetical protein 5132035 1215087 SAV_4182 Streptomyces avermitilis MA-4680 hypothetical protein NP_825359.1 5131802 D 227882 CDS NP_825360.1 29830726 1215088 5133481..5133660 1 NC_003155.4 hypothetical protein 5133660 1215088 SAV_4183 Streptomyces avermitilis MA-4680 hypothetical protein NP_825360.1 5133481 D 227882 CDS NP_825361.1 29830727 1215089 5133707..5134000 1 NC_003155.4 hypothetical protein 5134000 1215089 SAV_4184 Streptomyces avermitilis MA-4680 hypothetical protein NP_825361.1 5133707 D 227882 CDS NP_825362.1 29830728 1210901 5134202..5135131 1 NC_003155.4 RNA polymerase alternative sigma factor; RNA polymerase sigma factor 5135131 sig34 1210901 sig34 Streptomyces avermitilis MA-4680 RNA polymerase sigma factor NP_825362.1 5134202 D 227882 CDS NP_825363.1 29830729 1210902 5135376..5136299 1 NC_003155.4 RNA polymerase alternative sigma factor; RNA polymerase sigma factor 5136299 sig35 1210902 sig35 Streptomyces avermitilis MA-4680 RNA polymerase sigma factor NP_825363.1 5135376 D 227882 CDS NP_825364.1 29830730 1215090 5136384..5137199 1 NC_003155.4 hypothetical protein 5137199 1215090 SAV_4187 Streptomyces avermitilis MA-4680 hypothetical protein NP_825364.1 5136384 D 227882 CDS NP_825365.1 29830731 1215091 complement(5137228..5137506) 1 NC_003155.4 hypothetical protein 5137506 1215091 SAV_4188 Streptomyces avermitilis MA-4680 hypothetical protein NP_825365.1 5137228 R 227882 CDS NP_825366.1 29830732 1215092 5137672..5138187 1 NC_003155.4 MarR family transcriptional regulator 5138187 1215092 SAV_4189 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_825366.1 5137672 D 227882 CDS NP_825367.1 29830733 1215093 5138210..5140771 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 5140771 1215093 SAV_4190 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_825367.1 5138210 D 227882 CDS NP_825368.1 29830734 1215094 5140882..5141703 1 NC_003155.4 PF04264: YceI like family; hypothetical protein 5141703 1215094 SAV_4191 Streptomyces avermitilis MA-4680 hypothetical protein NP_825368.1 5140882 D 227882 CDS NP_825369.1 29830735 1215095 5141773..5142243 1 NC_003155.4 ATP/GTP-binding protein 5142243 1215095 SAV_4192 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_825369.1 5141773 D 227882 CDS NP_825370.1 29830736 1215096 complement(5142316..5143086) 1 NC_003155.4 TetR family transcriptional regulator 5143086 1215096 SAV_4193 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_825370.1 5142316 R 227882 CDS NP_825371.1 29830737 1215097 complement(5143193..5144689) 1 NC_003155.4 homolog of virginiamycin S resistance gene (varS), PF07690: Major Facilitator Superfamily; transmembrane efflux protein 5144689 1215097 SAV_4194 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_825371.1 5143193 R 227882 CDS NP_825372.1 29830738 1215098 complement(5144801..5147050) 1 NC_003155.4 PF02366: Dolichyl-phosphate-mannose-protein mannosyltransferase; hypothetical protein 5147050 1215098 SAV_4195 Streptomyces avermitilis MA-4680 hypothetical protein NP_825372.1 5144801 R 227882 CDS NP_825373.1 29830739 1215099 complement(5147047..5148588) 1 NC_003155.4 homolog of dolichyl-phosphate beta-glucosyltransferase, PF04138: GtrA-like protein; glycosyl transferase 5148588 1215099 SAV_4196 Streptomyces avermitilis MA-4680 glycosyl transferase NP_825373.1 5147047 R 227882 CDS NP_825374.1 29830740 1215100 complement(5148603..5150222) 1 NC_003155.4 two-component system sensor kinase 5150222 1215100 SAV_4197 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_825374.1 5148603 R 227882 CDS NP_825375.1 29830741 1215101 complement(5150219..5151028) 1 NC_003155.4 two-component system response regulator 5151028 1215101 SAV_4198 Streptomyces avermitilis MA-4680 two-component system response regulator NP_825375.1 5150219 R 227882 CDS NP_825376.1 29830742 1215102 complement(5151183..5152112) 1 NC_003155.4 PF04909: Amidohydrolase; hypothetical protein 5152112 1215102 SAV_4199 Streptomyces avermitilis MA-4680 hypothetical protein NP_825376.1 5151183 R 227882 CDS NP_825377.1 29830743 1215103 complement(5152096..5152542) 1 NC_003155.4 PF03992: Antibiotic biosynthesis monooxygenase; hypothetical protein 5152542 1215103 SAV_4200 Streptomyces avermitilis MA-4680 hypothetical protein NP_825377.1 5152096 R 227882 CDS NP_825378.1 29830744 1215104 complement(5152683..5153546) 1 NC_003155.4 hypothetical protein 5153546 1215104 SAV_4201 Streptomyces avermitilis MA-4680 hypothetical protein NP_825378.1 5152683 R 227882 CDS NP_825379.1 29830745 1215105 complement(5153627..5154115) 1 NC_003155.4 hypothetical protein 5154115 1215105 SAV_4202 Streptomyces avermitilis MA-4680 hypothetical protein NP_825379.1 5153627 R 227882 CDS NP_825380.1 29830746 1215106 5154416..5154820 1 NC_003155.4 similar to cell wall lysis enzyme of phage; near tRNA genes; peptidoglycan-binding protein 5154820 1215106 SAV_4203 Streptomyces avermitilis MA-4680 peptidoglycan-binding protein NP_825380.1 5154416 D 227882 CDS NP_825381.1 29830747 1215107 5155522..5155989 1 NC_003155.4 PF00720: Subtilisin inhibitor-like; protein 5155989 1215107 SAV_4204 Streptomyces avermitilis MA-4680 protein NP_825381.1 5155522 D 227882 CDS NP_825382.1 29830748 1215108 5156280..5160719 1 NC_003155.4 two-component system sensor kinase/response regulator, bifunctional protein 5160719 1215108 SAV_4205 Streptomyces avermitilis MA-4680 two-component system sensor kinase/response regulator, bifunctional protein NP_825382.1 5156280 D 227882 CDS NP_825383.1 29830749 1210905 complement(5160810..5162486) 1 NC_003155.4 activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 5162486 fadD9 1210905 fadD9 Streptomyces avermitilis MA-4680 long-chain-fatty-acid--CoA ligase NP_825383.1 5160810 R 227882 CDS NP_825384.1 29830750 1210906 complement(5162654..5163124) 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 5163124 sig36 1210906 sig36 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_825384.1 5162654 R 227882 CDS NP_825385.1 29830751 1210907 complement(5163382..5164548) 1 NC_003155.4 lipid-transfer protein 5164548 ltp3 1210907 ltp3 Streptomyces avermitilis MA-4680 lipid-transfer protein NP_825385.1 5163382 R 227882 CDS NP_825386.1 29830752 1215109 complement(5164545..5164940) 1 NC_003155.4 probably involved in the lipid metabolism, PF01575: MaoC like domain; hypothetical protein 5164940 1215109 SAV_4209 Streptomyces avermitilis MA-4680 hypothetical protein NP_825386.1 5164545 R 227882 CDS NP_825387.1 29830753 1210908 complement(5164937..5166073) 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 5166073 fadE28 1210908 fadE28 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_825387.1 5164937 R 227882 CDS NP_825388.1 29830754 1215110 complement(5166075..5167025) 1 NC_003155.4 PF01796: Domain of unknown function DUF35; hypothetical protein 5167025 1215110 SAV_4211 Streptomyces avermitilis MA-4680 hypothetical protein NP_825388.1 5166075 R 227882 CDS NP_825389.1 29830755 1210909 complement(5167022..5168311) 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 5168311 fadE22 1210909 fadE22 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_825389.1 5167022 R 227882 CDS NP_825390.1 29830756 1215111 complement(5168572..5168808) 1 NC_003155.4 hypothetical protein 5168808 1215111 SAV_4213 Streptomyces avermitilis MA-4680 hypothetical protein NP_825390.1 5168572 R 227882 CDS NP_825391.1 29830757 1215112 5169189..5170106 1 NC_003155.4 hypothetical protein 5170106 1215112 SAV_4214 Streptomyces avermitilis MA-4680 hypothetical protein NP_825391.1 5169189 D 227882 CDS NP_825392.1 29830758 1215113 complement(5172533..5172976) 1 NC_003155.4 IS1647-like transposase 5172976 1215113 SAV_4215 Streptomyces avermitilis MA-4680 IS1647-like transposase NP_825392.1 5172533 R 227882 CDS NP_825393.2 57833862 1215114 complement(5172868..5173350) 1 NC_003155.4 IS1647-like transposase 5173350 1215114 SAV_4216 Streptomyces avermitilis MA-4680 IS1647-like transposase NP_825393.2 5172868 R 227882 CDS NP_825394.1 29830760 1215115 5173661..5174278 1 NC_003155.4 hypothetical protein 5174278 1215115 SAV_4217 Streptomyces avermitilis MA-4680 hypothetical protein NP_825394.1 5173661 D 227882 CDS NP_825395.1 29830761 1215116 complement(5174345..5174863) 1 NC_003155.4 hypothetical protein 5174863 1215116 SAV_4218 Streptomyces avermitilis MA-4680 hypothetical protein NP_825395.1 5174345 R 227882 CDS NP_825396.1 29830762 1215117 5174965..5176368 1 NC_003155.4 PF01580: FtsK/SpoIIIE family; hypothetical protein 5176368 1215117 SAV_4219 Streptomyces avermitilis MA-4680 hypothetical protein NP_825396.1 5174965 D 227882 CDS NP_825397.1 29830763 1215118 5176576..5176899 1 NC_003155.4 hypothetical protein 5176899 1215118 SAV_4220 Streptomyces avermitilis MA-4680 hypothetical protein NP_825397.1 5176576 D 227882 CDS NP_825398.1 29830764 1215119 5176989..5177345 1 NC_003155.4 hypothetical protein 5177345 1215119 SAV_4221 Streptomyces avermitilis MA-4680 hypothetical protein NP_825398.1 5176989 D 227882 CDS NP_825399.1 29830765 1215120 5177342..5177554 1 NC_003155.4 hypothetical protein 5177554 1215120 SAV_4222 Streptomyces avermitilis MA-4680 hypothetical protein NP_825399.1 5177342 D 227882 CDS NP_825400.1 29830766 1215121 complement(5177841..5179259) 1 NC_003155.4 PF00089: Trypsin; serine protease 5179259 1215121 SAV_4223 Streptomyces avermitilis MA-4680 serine protease NP_825400.1 5177841 R 227882 CDS NP_825401.1 29830767 1210911 5179544..5180353 1 NC_003155.4 glycerophosphoryl diester phosphodiesterase 5180353 glpQ2 1210911 glpQ2 Streptomyces avermitilis MA-4680 glycerophosphoryl diester phosphodiesterase NP_825401.1 5179544 D 227882 CDS NP_825402.1 29830768 1215122 5180472..5181125 1 NC_003155.4 regulatory protein 5181125 1215122 SAV_4225 Streptomyces avermitilis MA-4680 regulatory protein NP_825402.1 5180472 D 227882 CDS NP_825403.1 29830769 1215123 5181331..5182296 1 NC_003155.4 PF02810: SEC-C motif; hypothetical protein 5182296 1215123 SAV_4226 Streptomyces avermitilis MA-4680 hypothetical protein NP_825403.1 5181331 D 227882 CDS NP_825404.1 29830770 1215124 complement(5182632..5183207) 1 NC_003155.4 hypothetical protein 5183207 1215124 SAV_4227 Streptomyces avermitilis MA-4680 hypothetical protein NP_825404.1 5182632 R 227882 CDS NP_825405.1 29830771 1215125 complement(5183263..5183928) 1 NC_003155.4 hypothetical protein 5183928 1215125 SAV_4228 Streptomyces avermitilis MA-4680 hypothetical protein NP_825405.1 5183263 R 227882 CDS NP_825406.1 29830772 1215126 5184516..5185910 1 NC_003155.4 PF01590: GAF domain; magnesium or manganese-dependent protein phosphatase 5185910 prpB7 1215126 prpB7 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_825406.1 5184516 D 227882 CDS NP_825407.1 29830773 1210912 5185995..5187458 1 NC_003155.4 PF00557: metallopeptidase family M24; aminopeptidase P 5187458 pepP 1210912 pepP Streptomyces avermitilis MA-4680 aminopeptidase P NP_825407.1 5185995 D 227882 CDS NP_825408.1 29830774 1215127 5187590..5189005 1 NC_003155.4 GntR family transcriptional regulator 5189005 1215127 SAV_4231 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_825408.1 5187590 D 227882 CDS NP_825409.1 29830775 1215128 5189096..5190565 1 NC_003155.4 PF07690: Major Facilitator Superfamily; hypothetical protein 5190565 1215128 SAV_4232 Streptomyces avermitilis MA-4680 hypothetical protein NP_825409.1 5189096 D 227882 CDS NP_825410.1 29830776 1210913 complement(5190540..5191379) 1 NC_003155.4 2-(5''-triphosphoribosyl)-3'-dephospho- CoA synthase 5191379 mdcB 1210913 mdcB Streptomyces avermitilis MA-4680 2-(5''-triphosphoribosyl)-3'-dephospho- CoA synthase NP_825410.1 5190540 R 227882 CDS NP_825411.1 29830777 1215129 complement(5191389..5192423) 1 NC_003155.4 PF00775: Dioxygenase; protocatechuate dioxygenase 5192423 1215129 SAV_4234 Streptomyces avermitilis MA-4680 protocatechuate dioxygenase NP_825411.1 5191389 R 227882 CDS NP_825412.1 29830778 1215130 complement(5192478..5195684) 1 NC_003155.4 PF01885: RNA 2'-phosphotransferase, Tpt1 / KptA family; hypothetical protein 5195684 1215130 SAV_4235 Streptomyces avermitilis MA-4680 hypothetical protein NP_825412.1 5192478 R 227882 CDS NP_825413.1 29830779 1215131 complement(5195791..5196249) 1 NC_003155.4 PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; hypothetical protein 5196249 1215131 SAV_4236 Streptomyces avermitilis MA-4680 hypothetical protein NP_825413.1 5195791 R 227882 CDS NP_825414.1 29830780 1215132 5196492..5197385 1 NC_003155.4 hypothetical protein 5197385 1215132 SAV_4237 Streptomyces avermitilis MA-4680 hypothetical protein NP_825414.1 5196492 D 227882 CDS NP_825415.1 29830781 1215133 5197592..5198326 1 NC_003155.4 hypothetical protein 5198326 1215133 SAV_4238 Streptomyces avermitilis MA-4680 hypothetical protein NP_825415.1 5197592 D 227882 CDS NP_825416.1 29830782 1215134 5198431..5199084 1 NC_003155.4 PF02630: SCO1/SenC; hypothetical protein 5199084 1215134 SAV_4239 Streptomyces avermitilis MA-4680 hypothetical protein NP_825416.1 5198431 D 227882 CDS NP_825417.1 29830783 1215135 5199081..5199548 1 NC_003155.4 PF04314: Protein of unknown function (DUF461); hypothetical protein 5199548 1215135 SAV_4240 Streptomyces avermitilis MA-4680 hypothetical protein NP_825417.1 5199081 D 227882 CDS NP_825418.1 29830784 1215136 5199736..5201820 1 NC_003155.4 PF04234: Copper resistance protein CopC; integral membrane protein 5201820 1215136 SAV_4241 Streptomyces avermitilis MA-4680 integral membrane protein NP_825418.1 5199736 D 227882 CDS NP_825419.1 29830785 1215137 5201829..5203190 1 NC_003155.4 PF04261: Dyp-type peroxidase family; hypothetical protein 5203190 1215137 SAV_4242 Streptomyces avermitilis MA-4680 hypothetical protein NP_825419.1 5201829 D 227882 CDS NP_825420.1 29830786 1210914 5203261..5204193 1 NC_003155.4 prephenate dehydratase 5204193 pheA 1210914 pheA Streptomyces avermitilis MA-4680 prephenate dehydratase NP_825420.1 5203261 D 227882 CDS NP_825421.1 29830787 1210915 5204797..5206074 1 NC_003155.4 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 5206074 serS1 1210915 serS1 Streptomyces avermitilis MA-4680 seryl-tRNA synthetase NP_825421.1 5204797 D 227882 CDS NP_825422.1 29830788 1215138 5206071..5206901 1 NC_003155.4 PF00702: haloacid dehalogenase-like hydrolase; hydrolase 5206901 1215138 SAV_4245 Streptomyces avermitilis MA-4680 hydrolase NP_825422.1 5206071 D 227882 CDS NP_825423.1 29830789 1215139 complement(5207285..5207524) 1 NC_003155.4 hypothetical protein 5207524 1215139 SAV_4246 Streptomyces avermitilis MA-4680 hypothetical protein NP_825423.1 5207285 R 227882 CDS NP_825424.1 29830790 1215140 complement(5207671..5208390) 1 NC_003155.4 integral membrane protein 5208390 1215140 SAV_4247 Streptomyces avermitilis MA-4680 integral membrane protein NP_825424.1 5207671 R 227882 CDS NP_825425.1 29830791 1215141 complement(5208401..5209312) 1 NC_003155.4 ABC transporter ATP-binding protein 5209312 1215141 SAV_4248 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_825425.1 5208401 R 227882 CDS NP_825426.1 29830792 1215142 complement(5209309..5210238) 1 NC_003155.4 integral membrane protein 5210238 1215142 SAV_4249 Streptomyces avermitilis MA-4680 integral membrane protein NP_825426.1 5209309 R 227882 CDS NP_825427.1 29830793 1215143 complement(5210228..5211190) 1 NC_003155.4 ABC transporter ATP-binding protein 5211190 1215143 SAV_4250 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_825427.1 5210228 R 227882 CDS NP_825428.1 29830794 1215144 5211430..5212308 1 NC_003155.4 hypothetical protein 5212308 1215144 SAV_4251 Streptomyces avermitilis MA-4680 hypothetical protein NP_825428.1 5211430 D 227882 CDS NP_825429.1 29830795 1215145 5212305..5214059 1 NC_003155.4 PF00106: short chain dehydrogenase; short chain dehydrogenase 5214059 1215145 SAV_4252 Streptomyces avermitilis MA-4680 short chain dehydrogenase NP_825429.1 5212305 D 227882 CDS NP_825430.1 29830796 1215146 5214056..5214985 1 NC_003155.4 hypothetical protein 5214985 1215146 SAV_4253 Streptomyces avermitilis MA-4680 hypothetical protein NP_825430.1 5214056 D 227882 CDS NP_825431.1 29830797 1215147 5215099..5216022 1 NC_003155.4 MerR family transcriptional regulator 5216022 1215147 SAV_4254 Streptomyces avermitilis MA-4680 MerR family transcriptional regulator NP_825431.1 5215099 D 227882 CDS NP_825432.1 29830798 1215148 5216144..5217214 1 NC_003155.4 PF00296: Luciferase-like monooxygenase; hypothetical protein 5217214 1215148 SAV_4255 Streptomyces avermitilis MA-4680 hypothetical protein NP_825432.1 5216144 D 227882 CDS NP_825433.1 29830799 1215149 5217388..5218305 1 NC_003155.4 PF00702: haloacid dehalogenase-like hydrolase; hypothetical protein 5218305 1215149 SAV_4256 Streptomyces avermitilis MA-4680 hypothetical protein NP_825433.1 5217388 D 227882 CDS NP_825434.1 29830800 1215150 complement(5218386..5220092) 1 NC_003155.4 two-component system sensor kinase 5220092 1215150 SAV_4257 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_825434.1 5218386 R 227882 CDS NP_825435.1 29830801 1210917 complement(5220167..5223721) 1 NC_003155.4 ABC transporter ATP-binding protein 5223721 cydCD 1210917 cydCD Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_825435.1 5220167 R 227882 CDS NP_825436.1 29830802 1210918 complement(5223782..5224786) 1 NC_003155.4 cytochrome bd-I oxidase subunit II 5224786 cydB1 1210918 cydB1 Streptomyces avermitilis MA-4680 cytochrome bd-I oxidase subunit II NP_825436.1 5223782 R 227882 CDS NP_825437.1 29830803 1210919 complement(5224806..5226314) 1 NC_003155.4 cytochrome bd-I oxidase subunit I 5226314 cydA1 1210919 cydA1 Streptomyces avermitilis MA-4680 cytochrome bd-I oxidase subunit I NP_825437.1 5224806 R 227882 CDS NP_825438.1 29830804 1210920 complement(5226731..5227810) 1 NC_003155.4 EC:2.6.1.9; putative aminotransferase 5227810 hisC2 1210920 hisC2 Streptomyces avermitilis MA-4680 putative aminotransferase NP_825438.1 5226731 R 227882 CDS NP_825439.1 29830805 1210921 5228198..5229310 1 NC_003155.4 LacI family transcriptional regulator 5229310 rstP 1210921 rstP Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_825439.1 5228198 D 227882 CDS NP_825440.1 29830806 1210922 5229540..5230649 1 NC_003155.4 PF00149: Calcineurin-like phosphoesterase; serine/threonine protein phosphatase 5230649 prpA2 1210922 prpA2 Streptomyces avermitilis MA-4680 serine/threonine protein phosphatase NP_825440.1 5229540 D 227882 CDS NP_825441.1 29830807 1215151 5230838..5231695 1 NC_003155.4 hypothetical protein 5231695 1215151 SAV_4264 Streptomyces avermitilis MA-4680 hypothetical protein NP_825441.1 5230838 D 227882 CDS NP_825442.1 29830808 1210923 complement(5231881..5233686) 1 NC_003155.4 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 5233686 thiA 1210923 thiA Streptomyces avermitilis MA-4680 thiamine biosynthesis protein ThiC NP_825442.1 5231881 R 227882 CDS NP_825443.1 29830809 1215152 5233907..5235349 1 NC_003155.4 hypothetical protein 5235349 1215152 SAV_4266 Streptomyces avermitilis MA-4680 hypothetical protein NP_825443.1 5233907 D 227882 CDS NP_825444.1 29830810 1210924 complement(5235517..5235924) 1 NC_003155.4 PF04686: Streptomyces sporulation and cell division protein, SsgA; cell division protein, regulatory protein 5235924 ssgA1 1210924 ssgA1 Streptomyces avermitilis MA-4680 cell division protein, regulatory protein NP_825444.1 5235517 R 227882 CDS NP_825445.1 29830811 1210925 complement(5236053..5236778) 1 NC_003155.4 IclR family transcriptional regulator 5236778 ssfR 1210925 ssfR Streptomyces avermitilis MA-4680 IclR family transcriptional regulator NP_825445.1 5236053 R 227882 CDS NP_825446.1 29830812 1215153 complement(5237173..5237385) 1 NC_003155.4 membrane spanning protein 5237385 1215153 SAV_4269 Streptomyces avermitilis MA-4680 membrane spanning protein NP_825446.1 5237173 R 227882 CDS NP_825447.1 29830813 1215154 complement(5237549..5237866) 1 NC_003155.4 PF00190: Cupin; hypothetical protein 5237866 1215154 SAV_4270 Streptomyces avermitilis MA-4680 hypothetical protein NP_825447.1 5237549 R 227882 CDS NP_825448.1 29830814 1215155 5237980..5238360 1 NC_003155.4 PF04020: Membrane protein of unknown function; hypothetical protein 5238360 1215155 SAV_4271 Streptomyces avermitilis MA-4680 hypothetical protein NP_825448.1 5237980 D 227882 CDS NP_825449.1 29830815 1210926 5238369..5238860 1 NC_003155.4 PF01451: Low molecular weight phosphotyrosine protein phosphatase; low molecular weight protein tyrosine phosphatase 5238860 ptpB2 1210926 ptpB2 Streptomyces avermitilis MA-4680 low molecular weight protein tyrosine phosphatase NP_825449.1 5238369 D 227882 CDS NP_825450.1 29830816 1210927 5238857..5240002 1 NC_003155.4 catalyzes the formation of cysteine and 2-oxobutanoate from cystathionine; cystathionine gamma-lyase 5240002 cysA1 1210927 cysA1 Streptomyces avermitilis MA-4680 cystathionine gamma-lyase NP_825450.1 5238857 D 227882 CDS NP_825451.1 29830817 1210928 5240218..5241123 1 NC_003155.4 LysR family transcriptional regulator 5241123 abaB1 1210928 abaB1 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_825451.1 5240218 D 227882 CDS NP_825452.1 29830818 1215156 5241186..5241668 1 NC_003155.4 PF00293: NUDIX domain; hypothetical protein 5241668 1215156 SAV_4275 Streptomyces avermitilis MA-4680 hypothetical protein NP_825452.1 5241186 D 227882 CDS NP_825453.1 29830819 1215157 complement(5241692..5243389) 1 NC_003155.4 flavohemoprotein 5243389 fhbA 1215157 fhbA Streptomyces avermitilis MA-4680 flavohemoprotein NP_825453.1 5241692 R 227882 CDS NP_825454.1 29830820 1215158 complement(5243788..5244447) 1 NC_003155.4 PF00702: haloacid dehalogenase-like hydrolase; hypothetical protein 5244447 1215158 SAV_4277 Streptomyces avermitilis MA-4680 hypothetical protein NP_825454.1 5243788 R 227882 CDS NP_825455.1 29830821 1215159 5244596..5245462 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; hypothetical protein 5245462 1215159 SAV_4278 Streptomyces avermitilis MA-4680 hypothetical protein NP_825455.1 5244596 D 227882 CDS NP_825456.1 29830822 1215160 complement(5245573..5245992) 1 NC_003155.4 PF03928: Domain of unknown function (DUF336); hypothetical protein 5245992 1215160 SAV_4279 Streptomyces avermitilis MA-4680 hypothetical protein NP_825456.1 5245573 R 227882 CDS NP_825457.1 29830823 1215161 complement(5246135..5247343) 1 NC_003155.4 similar to cmlR, PF07690: Major Facilitator Superfamily; transmembrane efflux protein 5247343 1215161 SAV_4280 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_825457.1 5246135 R 227882 CDS NP_825458.1 29830824 1215162 5247484..5247942 1 NC_003155.4 MarR family transcriptional regulator 5247942 1215162 SAV_4281 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_825458.1 5247484 D 227882 CDS NP_825459.1 29830825 1215163 5247952..5248404 1 NC_003155.4 transcriptional regulator 5248404 1215163 SAV_4282 Streptomyces avermitilis MA-4680 transcriptional regulator NP_825459.1 5247952 D 227882 CDS NP_825460.1 29830826 1210929 complement(5248526..5249911) 1 NC_003155.4 PF00144: Beta-lactamase; beta-lactamase 5249911 blaA2 1210929 blaA2 Streptomyces avermitilis MA-4680 beta-lactamase NP_825460.1 5248526 R 227882 CDS NP_825461.1 29830827 1210930 complement(5249988..5251463) 1 NC_003155.4 replicative DNA helicase 5251463 dnaB 1210930 dnaB Streptomyces avermitilis MA-4680 replicative DNA helicase NP_825461.1 5249988 R 227882 CDS NP_825462.1 29830828 1210931 5251914..5253260 1 NC_003155.4 DNA-damage-inducible protein F 5253260 dinF 1210931 dinF Streptomyces avermitilis MA-4680 DNA-damage-inducible protein F NP_825462.1 5251914 D 227882 CDS NP_825463.1 29830829 1210932 complement(5253458..5253904) 1 NC_003155.4 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 5253904 rplI 1210932 rplI Streptomyces avermitilis MA-4680 50S ribosomal protein L9 NP_825463.1 5253458 R 227882 CDS NP_825464.1 29830830 1210933 complement(5253923..5254159) 1 NC_003155.4 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 5254159 rpsR 1210933 rpsR Streptomyces avermitilis MA-4680 30S ribosomal protein S18 NP_825464.1 5253923 R 227882 CDS NP_825465.1 29830831 1210934 complement(5254217..5254825) 1 NC_003155.4 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 5254825 ssb 1210934 ssb Streptomyces avermitilis MA-4680 single-stranded DNA-binding protein NP_825465.1 5254217 R 227882 CDS NP_825466.1 29830832 1210935 complement(5254905..5255195) 1 NC_003155.4 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 5255195 rpsF 1210935 rpsF Streptomyces avermitilis MA-4680 30S ribosomal protein S6 NP_825466.1 5254905 R 227882 CDS NP_825467.1 29830833 1215164 5255517..5255831 1 NC_003155.4 hypothetical protein 5255831 1215164 SAV_4290 Streptomyces avermitilis MA-4680 hypothetical protein NP_825467.1 5255517 D 227882 CDS NP_825468.1 29830834 1215165 5256054..5257175 1 NC_003155.4 PF02388: FemAB family; hypothetical protein 5257175 1215165 SAV_4291 Streptomyces avermitilis MA-4680 hypothetical protein NP_825468.1 5256054 D 227882 CDS NP_825469.1 29830835 1215166 5257274..5258305 1 NC_003155.4 PF01168: alanine racemase, N-terminal domain; hypothetical protein 5258305 1215166 SAV_4292 Streptomyces avermitilis MA-4680 hypothetical protein NP_825469.1 5257274 D 227882 CDS NP_825470.1 29830836 1215167 complement(5258389..5259906) 1 NC_003155.4 PF05007: Mannosyltransferase (PIG-M); hypothetical protein 5259906 1215167 SAV_4293 Streptomyces avermitilis MA-4680 hypothetical protein NP_825470.1 5258389 R 227882 CDS NP_825471.1 29830837 1210936 complement(5260016..5262805) 1 NC_003155.4 PF00912: Transglycosylase; penicillin-binding protein 5262805 pbp5 1210936 pbp5 Streptomyces avermitilis MA-4680 penicillin-binding protein NP_825471.1 5260016 R 227882 CDS NP_825472.1 29830838 1215168 5263084..5263767 1 NC_003155.4 ParR family transcriptional regulator 5263767 1215168 SAV_4295 Streptomyces avermitilis MA-4680 ParR family transcriptional regulator NP_825472.1 5263084 D 227882 CDS NP_825473.1 29830839 1215169 5263812..5264894 1 NC_003155.4 PF01658: Myo-inositol-1-phosphate synthase; 1L-myo-inositol-1-phosphate synthase 5264894 ino1 1215169 ino1 Streptomyces avermitilis MA-4680 1L-myo-inositol-1-phosphate synthase NP_825473.1 5263812 D 227882 CDS NP_825474.1 29830840 1215170 5264972..5266234 1 NC_003155.4 PF07690: Major Facilitator Superfamily; hypothetical protein 5266234 1215170 SAV_4297 Streptomyces avermitilis MA-4680 hypothetical protein NP_825474.1 5264972 D 227882 CDS NP_825475.1 29830841 1215171 5266349..5266840 1 NC_003155.4 hypothetical protein 5266840 1215171 SAV_4298 Streptomyces avermitilis MA-4680 hypothetical protein NP_825475.1 5266349 D 227882 CDS NP_825476.1 29830842 1210937 complement(5266959..5268401) 1 NC_003155.4 RNA nucleotidyltransferase 5268401 pcnA 1210937 pcnA Streptomyces avermitilis MA-4680 RNA nucleotidyltransferase NP_825476.1 5266959 R 227882 CDS NP_825477.1 29830843 1215172 5268648..5271065 1 NC_003155.4 hypothetical protein 5271065 1215172 SAV_4300 Streptomyces avermitilis MA-4680 hypothetical protein NP_825477.1 5268648 D 227882 CDS NP_825478.1 29830844 1215173 5271112..5273379 1 NC_003155.4 PF03023: MviN-like protein; hypothetical protein 5273379 1215173 SAV_4301 Streptomyces avermitilis MA-4680 hypothetical protein NP_825478.1 5271112 D 227882 CDS NP_825479.1 29830845 1215174 5273498..5275219 1 NC_003155.4 PF00069: Protein kinase domain; hypothetical protein 5275219 1215174 SAV_4302 Streptomyces avermitilis MA-4680 hypothetical protein NP_825479.1 5273498 D 227882 CDS NP_825480.1 29830846 1210938 5275249..5275962 1 NC_003155.4 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription: in Mycobacterium bovis this protein has been shown to be active at high temperatures and during stationary phase; RNA polymerase sigma factor SigM 5275962 sig37 1210938 sig37 Streptomyces avermitilis MA-4680 RNA polymerase sigma factor SigM NP_825480.1 5275249 D 227882 CDS NP_825481.1 29830847 1215175 5275959..5276882 1 NC_003155.4 hypothetical protein 5276882 1215175 SAV_4304 Streptomyces avermitilis MA-4680 hypothetical protein NP_825481.1 5275959 D 227882 CDS NP_825482.1 29830848 1210939 5277067..5278038 1 NC_003155.4 thioredoxin reductase (NADPH) 5278038 trxB1 1210939 trxB1 Streptomyces avermitilis MA-4680 thioredoxin reductase (NADPH) NP_825482.1 5277067 D 227882 CDS NP_825483.1 29830849 1210940 5278082..5278414 1 NC_003155.4 thioredoxin 5278414 trxA1 1210940 trxA1 Streptomyces avermitilis MA-4680 thioredoxin NP_825483.1 5278082 D 227882 CDS NP_825484.1 29830850 1215176 complement(5278554..5279171) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; hypothetical protein 5279171 1215176 SAV_4307 Streptomyces avermitilis MA-4680 hypothetical protein NP_825484.1 5278554 R 227882 CDS NP_825485.1 29830851 1210941 complement(5279501..5280604) 1 NC_003155.4 PF02195: ParB-like nuclease domain; ParB-like protein 5280604 parB 1210941 parB Streptomyces avermitilis MA-4680 ParB-like protein NP_825485.1 5279501 R 227882 CDS NP_825486.1 29830852 1210942 complement(5280601..5281674) 1 NC_003155.4 PF01656: CobQ/CobB/MinD/ParA nucleotide binding domain; partitioning or sporulation protein 5281674 parA1 1210942 parA1 Streptomyces avermitilis MA-4680 partitioning or sporulation protein NP_825486.1 5280601 R 227882 CDS NP_825487.1 29830853 1210943 complement(5281976..5282716) 1 NC_003155.4 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 5282716 gidB 1210943 gidB Streptomyces avermitilis MA-4680 16S rRNA methyltransferase GidB NP_825487.1 5281976 R 227882 CDS NP_825488.1 29830854 1210944 complement(5282854..5283366) 1 NC_003155.4 Jag-like protein 5283366 jag 1210944 jag Streptomyces avermitilis MA-4680 Jag-like protein NP_825488.1 5282854 R 227882 CDS NP_825489.1 29830855 1215177 complement(5283382..5284668) 1 NC_003155.4 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; putative inner membrane protein translocase component YidC 5284668 1215177 SAV_4312 Streptomyces avermitilis MA-4680 putative inner membrane protein translocase component YidC NP_825489.1 5283382 R 227882 CDS NP_825490.1 29830856 1215178 complement(5284672..5285025) 1 NC_003155.4 PF01809: Domain of unknown function DUF37; hypothetical protein 5285025 1215178 SAV_4313 Streptomyces avermitilis MA-4680 hypothetical protein NP_825490.1 5284672 R 227882 CDS NP_825491.1 29830857 1210945 complement(5285022..5285393) 1 NC_003155.4 PF00825: Ribonuclease P; RNase P component 5285393 rnpA 1210945 rnpA Streptomyces avermitilis MA-4680 RNase P component NP_825491.1 5285022 R 227882 CDS NP_825492.1 29830858 1210946 complement(5285412..5285549) 1 NC_003155.4 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 5285549 rpmH 1210946 rpmH Streptomyces avermitilis MA-4680 50S ribosomal protein L34 NP_825492.1 5285412 R 227882 CDS NP_825493.1 29830859 1210947 5285972..5287933 1 NC_003155.4 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 5287933 dnaA 1210947 dnaA Streptomyces avermitilis MA-4680 chromosomal replication initiation protein NP_825493.1 5285972 D 227882 CDS NP_825494.1 29830860 1210948 5289024..5290154 1 NC_003155.4 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 5290154 dnaN1 1210948 dnaN1 Streptomyces avermitilis MA-4680 DNA polymerase III subunit beta NP_825494.1 5289024 D 227882 CDS NP_825495.1 29830861 1210949 5290374..5291249 1 NC_003155.4 similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate; 6-phosphogluconate dehydrogenase 5291249 gnd2 1210949 gnd2 Streptomyces avermitilis MA-4680 6-phosphogluconate dehydrogenase NP_825495.1 5290374 D 227882 CDS NP_825496.1 29830862 1210950 5291312..5292433 1 NC_003155.4 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 5292433 recF 1210950 recF Streptomyces avermitilis MA-4680 recombination protein F NP_825496.1 5291312 D 227882 CDS NP_825497.1 29830863 1215179 5292430..5292975 1 NC_003155.4 PF05258: Protein of unknown function (DUF721); hypothetical protein 5292975 1215179 SAV_4320 Streptomyces avermitilis MA-4680 hypothetical protein NP_825497.1 5292430 D 227882 CDS NP_825498.1 29830864 1210951 5293712..5295790 1 NC_003155.4 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 5295790 gyrB 1210951 gyrB Streptomyces avermitilis MA-4680 DNA gyrase subunit B NP_825498.1 5293712 D 227882 CDS NP_825499.1 29830865 1210952 5295833..5298427 1 NC_003155.4 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 5298427 gyrA 1210952 gyrA Streptomyces avermitilis MA-4680 DNA gyrase subunit A NP_825499.1 5295833 D 227882 CDS NP_825500.1 29830866 1215180 5298567..5299181 1 NC_003155.4 hypothetical protein 5299181 1215180 SAV_4323 Streptomyces avermitilis MA-4680 hypothetical protein NP_825500.1 5298567 D 227882 CDS NP_825501.1 29830867 1215181 complement(5299713..5300060) 1 NC_003155.4 hypothetical protein 5300060 1215181 SAV_4324 Streptomyces avermitilis MA-4680 hypothetical protein NP_825501.1 5299713 R 227882 CDS NP_825502.1 29830868 1215182 5300774..5302279 1 NC_003155.4 hypothetical protein 5302279 1215182 SAV_4325 Streptomyces avermitilis MA-4680 hypothetical protein NP_825502.1 5300774 D 227882 CDS NP_825503.1 29830869 1210954 complement(5302280..5303974) 1 NC_003155.4 serine/threonine protein kinase 5303974 pkn10 1210954 pkn10 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_825503.1 5302280 R 227882 CDS NP_825504.1 29830870 1215183 complement(5304174..5304722) 1 NC_003155.4 DNA-binding protein 5304722 1215183 SAV_4327 Streptomyces avermitilis MA-4680 DNA-binding protein NP_825504.1 5304174 R 227882 CDS NP_825505.1 29830871 1215184 complement(5305386..5306087) 1 NC_003155.4 regulatory protein 5306087 1215184 SAV_4328 Streptomyces avermitilis MA-4680 regulatory protein NP_825505.1 5305386 R 227882 CDS NP_825506.1 29830872 1210956 5306491..5307051 1 NC_003155.4 peptidyl-prolyl cis-trans isomerase 5307051 ppiA 1210956 ppiA Streptomyces avermitilis MA-4680 peptidyl-prolyl cis-trans isomerase NP_825506.1 5306491 D 227882 CDS NP_825507.1 29830873 1215185 5307277..5308173 1 NC_003155.4 PF01694: Rhomboid family; hypothetical protein 5308173 1215185 SAV_4330 Streptomyces avermitilis MA-4680 hypothetical protein NP_825507.1 5307277 D 227882 CDS NP_825508.1 29830874 1210957 complement(5308456..5308710) 1 NC_003155.4 integral membrane protein involved in inhibition of the Z-ring formation; putative septation inhibitor protein 5308710 whiP 1210957 whiP Streptomyces avermitilis MA-4680 putative septation inhibitor protein NP_825508.1 5308456 R 227882 CDS NP_825509.1 29830875 1215186 5308853..5309665 1 NC_003155.4 PF05949: Bacterial protein of unknown function (DUF881); hypothetical protein 5309665 1215186 SAV_4332 Streptomyces avermitilis MA-4680 hypothetical protein NP_825509.1 5308853 D 227882 CDS NP_825510.1 29830876 1215187 5309712..5310404 1 NC_003155.4 PF04203: sortase family; hypothetical protein 5310404 1215187 SAV_4333 Streptomyces avermitilis MA-4680 hypothetical protein NP_825510.1 5309712 D 227882 CDS NP_825511.1 29830877 1215188 5310409..5310597 1 NC_003155.4 hypothetical protein 5310597 1215188 SAV_4334 Streptomyces avermitilis MA-4680 hypothetical protein NP_825511.1 5310409 D 227882 CDS NP_825512.1 29830878 1210958 5310594..5311232 1 NC_003155.4 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 5311232 pabA 1210958 pabA Streptomyces avermitilis MA-4680 para-aminobenzoate synthase component II NP_825512.1 5310594 D 227882 CDS NP_825513.1 29830879 1215189 5311229..5312578 1 NC_003155.4 PF04203: sortase family; hypothetical protein 5312578 1215189 SAV_4336 Streptomyces avermitilis MA-4680 hypothetical protein NP_825513.1 5311229 D 227882 CDS NP_825514.1 29830880 1215190 5312592..5313332 1 NC_003155.4 PF04203: sortase family; hypothetical protein 5313332 1215190 SAV_4337 Streptomyces avermitilis MA-4680 hypothetical protein NP_825514.1 5312592 D 227882 CDS NP_825515.1 29830881 1210959 complement(5313395..5315398) 1 NC_003155.4 serine/threonine protein kinase 5315398 pkn11 1210959 pkn11 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_825515.1 5313395 R 227882 CDS NP_825516.1 29830882 1210960 complement(5315569..5317053) 1 NC_003155.4 PF00905: Penicillin binding protein transpeptidase domain; penicillin-binding protein 5317053 pbp6 1210960 pbp6 Streptomyces avermitilis MA-4680 penicillin-binding protein NP_825516.1 5315569 R 227882 CDS NP_825517.1 29830883 1210961 complement(5317050..5318498) 1 NC_003155.4 PF01098: Cell cycle protein; cell division membrane protein 5318498 ftsW3 1210961 ftsW3 Streptomyces avermitilis MA-4680 cell division membrane protein NP_825517.1 5317050 R 227882 CDS NP_825518.1 29830884 1215191 complement(5318525..5320069) 1 NC_003155.4 PF00481: Protein phosphatase 2C; magnesium or manganese-dependent protein phosphatase 5320069 prpB8 1215191 prpB8 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_825518.1 5318525 R 227882 CDS NP_825519.1 29830885 1215192 complement(5320190..5320717) 1 NC_003155.4 PF00498: FHA domain; hypothetical protein 5320717 1215192 SAV_4342 Streptomyces avermitilis MA-4680 hypothetical protein NP_825519.1 5320190 R 227882 CDS NP_825520.1 29830886 1215193 complement(5320728..5321585) 1 NC_003155.4 PF00498: FHA domain; hypothetical protein 5321585 1215193 SAV_4343 Streptomyces avermitilis MA-4680 hypothetical protein NP_825520.1 5320728 R 227882 CDS NP_825521.1 29830887 1215194 complement(5322321..5322974) 1 NC_003155.4 ACP phosphodiesterase 5322974 acpD 1215194 acpD Streptomyces avermitilis MA-4680 ACP phosphodiesterase NP_825521.1 5322321 R 227882 CDS NP_825522.1 29830888 1215195 5323110..5323517 1 NC_003155.4 PF01638: Transcriptional regulator; transcriptional regulator 5323517 1215195 SAV_4345 Streptomyces avermitilis MA-4680 transcriptional regulator NP_825522.1 5323110 D 227882 CDS NP_825523.1 29830889 1215196 5323799..5325265 1 NC_003155.4 hypothetical protein 5325265 1215196 SAV_4346 Streptomyces avermitilis MA-4680 hypothetical protein NP_825523.1 5323799 D 227882 CDS NP_825524.1 29830890 1215197 5325561..5326400 1 NC_003155.4 PF00226: DnaJ domain; hypothetical protein 5326400 1215197 SAV_4347 Streptomyces avermitilis MA-4680 hypothetical protein NP_825524.1 5325561 D 227882 CDS NP_825525.1 29830891 1215198 5326463..5326792 1 NC_003155.4 PF00581: Rhodanese-like domain; hypothetical protein 5326792 1215198 SAV_4348 Streptomyces avermitilis MA-4680 hypothetical protein NP_825525.1 5326463 D 227882 CDS NP_825526.1 29830892 1210963 complement(5326971..5328110) 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 5328110 fadE19 1210963 fadE19 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_825526.1 5326971 R 227882 CDS NP_825527.1 29830893 1210964 complement(5328286..5329350) 1 NC_003155.4 phenylacetate catabolism; phenylacetic acid degradation NADH oxidoreductase 5329350 paaE 1210964 paaE Streptomyces avermitilis MA-4680 phenylacetic acid degradation NADH oxidoreductase NP_825527.1 5328286 R 227882 CDS NP_825528.1 29830894 1210965 complement(5329350..5329862) 1 NC_003155.4 phenylacetate catabolism; phenylacetic acid degradation protein 5329862 paaD 1210965 paaD Streptomyces avermitilis MA-4680 phenylacetic acid degradation protein NP_825528.1 5329350 R 227882 CDS NP_825529.1 29830895 1210966 complement(5329907..5330626) 1 NC_003155.4 phenylacetate catabolism; phenylacetic acid degradation protein 5330626 paaC 1210966 paaC Streptomyces avermitilis MA-4680 phenylacetic acid degradation protein NP_825529.1 5329907 R 227882 CDS NP_825530.1 29830896 1210967 complement(5330623..5330910) 1 NC_003155.4 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA; involved in phenylacetate degradation; phenylacetate-CoA oxygenase subunit PaaB 5330910 paaB 1210967 paaB Streptomyces avermitilis MA-4680 phenylacetate-CoA oxygenase subunit PaaB NP_825530.1 5330623 R 227882 CDS NP_825531.1 29830897 1210968 complement(5330912..5331931) 1 NC_003155.4 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA; phenylacetate-CoA oxygenase subunit PaaA 5331931 paaA 1210968 paaA Streptomyces avermitilis MA-4680 phenylacetate-CoA oxygenase subunit PaaA NP_825531.1 5330912 R 227882 CDS NP_825532.1 29830898 1215199 5332122..5333153 1 NC_003155.4 hypothetical protein 5333153 1215199 SAV_4355 Streptomyces avermitilis MA-4680 hypothetical protein NP_825532.1 5332122 D 227882 CDS NP_825533.1 29830899 1215200 5333153..5334382 1 NC_003155.4 hypothetical protein 5334382 1215200 SAV_4356 Streptomyces avermitilis MA-4680 hypothetical protein NP_825533.1 5333153 D 227882 CDS NP_825534.1 29830900 1215201 5334379..5335128 1 NC_003155.4 PF00588: SpoU rRNA Methylase family; rRNA methyltransferase 5335128 tsnR1 1215201 tsnR1 Streptomyces avermitilis MA-4680 rRNA methyltransferase NP_825534.1 5334379 D 227882 CDS NP_825535.1 29830901 1210969 complement(5335144..5336835) 1 NC_003155.4 phenylacetate catabolism; dehydrogenase 5336835 paaZ 1210969 paaZ Streptomyces avermitilis MA-4680 dehydrogenase NP_825535.1 5335144 R 227882 CDS NP_825536.1 29830902 1210970 5336984..5338498 1 NC_003155.4 converts 3-hydroxyadipyl-CoA to beta-ketoadipyl-CoA in phenylacetate degradation; 3-hydroxy-acyl-CoA dehydrogenase 5338498 paaH 1210970 paaH Streptomyces avermitilis MA-4680 3-hydroxy-acyl-CoA dehydrogenase NP_825536.1 5336984 D 227882 CDS NP_825537.1 29830903 1215202 5338495..5339085 1 NC_003155.4 TetR family transcriptional regulator 5339085 1215202 SAV_4360 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_825537.1 5338495 D 227882 CDS NP_825538.1 29830904 1215203 complement(5339088..5339495) 1 NC_003155.4 transcription regulator AsnC 5339495 1215203 SAV_4361 Streptomyces avermitilis MA-4680 transcription regulator AsnC NP_825538.1 5339088 R 227882 CDS NP_825539.1 29830905 1210971 5339763..5340908 1 NC_003155.4 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) E1-alpha chain 5340908 bkdA 1210971 bkdA Streptomyces avermitilis MA-4680 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) E1-alpha chain NP_825539.1 5339763 D 227882 CDS NP_825540.1 29830906 1210972 5340982..5341986 1 NC_003155.4 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) E1-beta chain 5341986 bkdB 1210972 bkdB Streptomyces avermitilis MA-4680 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) E1-beta chain NP_825540.1 5340982 D 227882 CDS NP_825541.1 29830907 1210973 5341986..5343353 1 NC_003155.4 branched-chain alpha-keto acid dehydrogenase subunit E2 5343353 bkdC 1210973 bkdC Streptomyces avermitilis MA-4680 branched-chain alpha-keto acid dehydrogenase subunit E2 NP_825541.1 5341986 D 227882 CDS NP_825542.1 29830908 1210974 5343429..5344316 1 NC_003155.4 molybdopterin-guanine dinucleotide biosynthesis protein 5344316 mobA 1210974 mobA Streptomyces avermitilis MA-4680 molybdopterin-guanine dinucleotide biosynthesis protein NP_825542.1 5343429 D 227882 CDS NP_825543.1 29830909 1210975 5344379..5345773 1 NC_003155.4 molybdopterin biosynthesis protein 5345773 moaA2 1210975 moaA2 Streptomyces avermitilis MA-4680 molybdopterin biosynthesis protein NP_825543.1 5344379 D 227882 CDS NP_825544.1 29830910 1215204 5345833..5346867 1 NC_003155.4 PF02254: TrkA-N domain; hypothetical protein 5346867 1215204 SAV_4367 Streptomyces avermitilis MA-4680 hypothetical protein NP_825544.1 5345833 D 227882 CDS NP_825545.1 29830911 1210976 5346952..5347932 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; quinone oxidoreductase 5347932 qor 1210976 qor Streptomyces avermitilis MA-4680 quinone oxidoreductase NP_825545.1 5346952 D 227882 CDS NP_825546.1 29830912 1215205 complement(5347961..5348923) 1 NC_003155.4 hypothetical protein 5348923 1215205 SAV_4369 Streptomyces avermitilis MA-4680 hypothetical protein NP_825546.1 5347961 R 227882 CDS NP_825547.1 29830913 1215206 5348987..5349532 1 NC_003155.4 hypothetical protein 5349532 1215206 SAV_4370 Streptomyces avermitilis MA-4680 hypothetical protein NP_825547.1 5348987 D 227882 CDS NP_825548.1 29830914 1210977 complement(5349704..5351356) 1 NC_003155.4 serine/threonine protein kinase 5351356 pkn12 1210977 pkn12 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_825548.1 5349704 R 227882 CDS NP_825549.1 29830915 1210978 5351732..5353231 1 NC_003155.4 serine/threonine protein kinase 5353231 pkn13 1210978 pkn13 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_825549.1 5351732 D 227882 CDS NP_825550.1 29830916 1215207 complement(5353436..5354485) 1 NC_003155.4 PF01636: Phosphotransferase enzyme family; hypothetical protein 5354485 1215207 SAV_4373 Streptomyces avermitilis MA-4680 hypothetical protein NP_825550.1 5353436 R 227882 CDS NP_825551.1 29830917 1215208 complement(5354574..5355068) 1 NC_003155.4 hypothetical protein 5355068 1215208 SAV_4374 Streptomyces avermitilis MA-4680 hypothetical protein NP_825551.1 5354574 R 227882 CDS NP_825552.1 29830918 1215209 complement(5355231..5355890) 1 NC_003155.4 two-component system response regulator 5355890 1215209 SAV_4375 Streptomyces avermitilis MA-4680 two-component system response regulator NP_825552.1 5355231 R 227882 CDS NP_825553.1 29830919 1210979 5356305..5357525 1 NC_003155.4 branched-chain alpha keto acid dehydrogenase E1 alpha subunit 5357525 bkdF 1210979 bkdF Streptomyces avermitilis MA-4680 branched-chain alpha keto acid dehydrogenase E1 alpha subunit NP_825553.1 5356305 D 227882 CDS NP_825554.1 29830920 1210980 5357527..5358504 1 NC_003155.4 branched-chain alpha keto acid dehydrogenase E1 beta subunit 5358504 bkdG 1210980 bkdG Streptomyces avermitilis MA-4680 branched-chain alpha keto acid dehydrogenase E1 beta subunit NP_825554.1 5357527 D 227882 CDS NP_825555.1 29830921 1210981 5358524..5359912 1 NC_003155.4 branched-chain alpha-keto acid dehydrogenase subunit E2 5359912 bkdH 1210981 bkdH Streptomyces avermitilis MA-4680 branched-chain alpha-keto acid dehydrogenase subunit E2 NP_825555.1 5358524 D 227882 CDS NP_825556.1 29830922 1210982 complement(5359989..5360819) 1 NC_003155.4 PF00768: D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase 5360819 dacD 1210982 dacD Streptomyces avermitilis MA-4680 D-alanyl-D-alanine carboxypeptidase NP_825556.1 5359989 R 227882 CDS NP_825557.1 29830923 1215210 5361083..5361766 1 NC_003155.4 GntR family transcriptional regulator 5361766 1215210 SAV_4380 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_825557.1 5361083 D 227882 CDS NP_825558.1 29830924 1215211 5361763..5363109 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane transport protein 5363109 1215211 SAV_4381 Streptomyces avermitilis MA-4680 transmembrane transport protein NP_825558.1 5361763 D 227882 CDS NP_825559.1 29830925 1215212 complement(5363265..5364089) 1 NC_003155.4 hypothetical protein 5364089 1215212 SAV_4382 Streptomyces avermitilis MA-4680 hypothetical protein NP_825559.1 5363265 R 227882 CDS NP_825560.1 29830926 1210983 5364245..5365051 1 NC_003155.4 PF00795: Carbon-nitrogen hydrolase; hydrolase 5365051 1210983 SAV_4383 Streptomyces avermitilis MA-4680 hydrolase NP_825560.1 5364245 D 227882 CDS NP_825561.1 29830927 1215213 complement(5365119..5365613) 1 NC_003155.4 PF04525: Protein of unknown function (DUF567); hypothetical protein 5365613 1215213 SAV_4384 Streptomyces avermitilis MA-4680 hypothetical protein NP_825561.1 5365119 R 227882 CDS NP_825562.1 29830928 1215214 complement(5365817..5366050) 1 NC_003155.4 hypothetical protein 5366050 1215214 SAV_4385 Streptomyces avermitilis MA-4680 hypothetical protein NP_825562.1 5365817 R 227882 CDS NP_825563.1 29830929 1215215 5366202..5367227 1 NC_003155.4 frameshift, PF01436: NHL repeat; hypothetical protein 5367227 1215215 SAV_4386 Streptomyces avermitilis MA-4680 hypothetical protein NP_825563.1 5366202 D 227882 CDS NP_825564.1 29830930 1215216 5367136..5368020 1 NC_003155.4 frameshift, PF01436: NHL repeat; hypothetical protein 5368020 1215216 SAV_4387 Streptomyces avermitilis MA-4680 hypothetical protein NP_825564.1 5367136 D 227882 CDS NP_825565.1 29830931 1215217 complement(5368069..5368317) 1 NC_003155.4 hypothetical protein 5368317 1215217 SAV_4388 Streptomyces avermitilis MA-4680 hypothetical protein NP_825565.1 5368069 R 227882 CDS NP_825566.1 29830932 1215218 complement(5368441..5369739) 1 NC_003155.4 catalyzes the removal of amino acids from the N termini of peptides; putative aminopeptidase 2 5369739 1215218 SAV_4389 Streptomyces avermitilis MA-4680 putative aminopeptidase 2 NP_825566.1 5368441 R 227882 CDS NP_825567.1 29830933 1210984 complement(5369895..5371721) 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 5371721 fadE24 1210984 fadE24 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_825567.1 5369895 R 227882 CDS NP_825568.1 29830934 1215219 5371864..5372328 1 NC_003155.4 hypothetical protein 5372328 1215219 SAV_4391 Streptomyces avermitilis MA-4680 hypothetical protein NP_825568.1 5371864 D 227882 CDS NP_825569.1 29830935 1215220 5372504..5373475 1 NC_003155.4 PF02678: Pirin, phage attachment site is located in the coding region.; pirin-like protein 5373475 1215220 SAV_4392 Streptomyces avermitilis MA-4680 pirin-like protein NP_825569.1 5372504 D 227882 CDS NP_825570.1 29830936 1215221 5373665..5374708 1 NC_003155.4 PF01594: Domain of unknown function DUF20; integral membrane protein 5374708 1215221 SAV_4393 Streptomyces avermitilis MA-4680 integral membrane protein NP_825570.1 5373665 D 227882 CDS NP_825571.1 29830937 1215222 complement(5374725..5376869) 1 NC_003155.4 PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; magnesium or manganese-dependent protein phosphatase 5376869 prpE3 1215222 prpE3 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_825571.1 5374725 R 227882 CDS NP_825572.1 29830938 1210986 5377024..5378787 1 NC_003155.4 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 5378787 aspS 1210986 aspS Streptomyces avermitilis MA-4680 aspartyl-tRNA synthetase NP_825572.1 5377024 D 227882 CDS NP_825573.1 29830939 1215223 5378974..5379849 1 NC_003155.4 PF00775: Dioxygenase; dioxygenase 5379849 1215223 SAV_4396 Streptomyces avermitilis MA-4680 dioxygenase NP_825573.1 5378974 D 227882 CDS NP_825574.1 29830940 1215224 5379859..5380140 1 NC_003155.4 hypothetical protein 5380140 1215224 SAV_4397 Streptomyces avermitilis MA-4680 hypothetical protein NP_825574.1 5379859 D 227882 CDS NP_825575.1 29830941 1215225 complement(5380424..5380867) 1 NC_003155.4 regulatory protein 5380867 1215225 SAV_4398 Streptomyces avermitilis MA-4680 regulatory protein NP_825575.1 5380424 R 227882 CDS NP_825576.1 29830942 1215226 5381111..5381959 1 NC_003155.4 DNA-binding protein 5381959 1215226 SAV_4399 Streptomyces avermitilis MA-4680 DNA-binding protein NP_825576.1 5381111 D 227882 CDS NP_825577.1 29830943 1215227 5382139..5382564 1 NC_003155.4 hypothetical protein 5382564 1215227 SAV_4400 Streptomyces avermitilis MA-4680 hypothetical protein NP_825577.1 5382139 D 227882 CDS NP_825578.1 29830944 1215228 complement(5382545..5383078) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 5383078 1215228 SAV_4401 Streptomyces avermitilis MA-4680 acetyltransferase NP_825578.1 5382545 R 227882 CDS NP_825579.1 29830945 1215229 complement(5383149..5383634) 1 NC_003155.4 hypothetical protein 5383634 1215229 SAV_4402 Streptomyces avermitilis MA-4680 hypothetical protein NP_825579.1 5383149 R 227882 CDS NP_825580.1 29830946 1210987 complement(5383799..5385523) 1 NC_003155.4 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 5385523 metS 1210987 metS Streptomyces avermitilis MA-4680 methionyl-tRNA synthetase NP_825580.1 5383799 R 227882 CDS NP_825581.1 29830947 1215230 complement(5385730..5387478) 1 NC_003155.4 PF00092: von Willebrand factor type A domain; hypothetical protein 5387478 1215230 SAV_4404 Streptomyces avermitilis MA-4680 hypothetical protein NP_825581.1 5385730 R 227882 CDS NP_825582.1 29830948 1215231 5387779..5389881 1 NC_003155.4 PF05787: Bacterial protein of unknown function (DUF839); hypothetical protein 5389881 1215231 SAV_4405 Streptomyces avermitilis MA-4680 hypothetical protein NP_825582.1 5387779 D 227882 CDS NP_825583.1 29830949 1215232 complement(5389939..5390889) 1 NC_003155.4 LysR family transcriptional regulator 5390889 1215232 SAV_4406 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_825583.1 5389939 R 227882 CDS NP_825584.1 29830950 1215233 5391097..5391780 1 NC_003155.4 PF02031: Streptomyces extracellular neutral proteinase (M7) family; metalloprotease 5391780 1215233 SAV_4407 Streptomyces avermitilis MA-4680 metalloprotease NP_825584.1 5391097 D 227882 CDS NP_825585.1 29830951 1215234 complement(5391918..5393858) 1 NC_003155.4 PF05976: Bacterial membrane protein of unknown function (DUF893); integral membrane protein 5393858 1215234 SAV_4408 Streptomyces avermitilis MA-4680 integral membrane protein NP_825585.1 5391918 R 227882 CDS NP_825586.1 29830952 1215235 complement(5393921..5394934) 1 NC_003155.4 PF03372: Endonuclease/Exonuclease/phosphatase family; hypothetical protein 5394934 1215235 SAV_4409 Streptomyces avermitilis MA-4680 hypothetical protein NP_825586.1 5393921 R 227882 CDS NP_825587.1 29830953 1215236 complement(5395143..5395928) 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 5395928 1215236 SAV_4410 Streptomyces avermitilis MA-4680 hydrolase NP_825587.1 5395143 R 227882 CDS NP_825588.1 29830954 1215237 5396010..5397446 1 NC_003155.4 frameshift; GntR family transcriptional regulator 5397446 1215237 SAV_4411 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_825588.1 5396010 D 227882 CDS NP_825589.1 29830955 1215238 5396629..5397363 1 NC_003155.4 frameshift; transcriptional regulator 5397363 1215238 SAV_4412 Streptomyces avermitilis MA-4680 transcriptional regulator NP_825589.1 5396629 D 227882 CDS NP_825590.1 29830956 1215239 complement(5397278..5398177) 1 NC_003155.4 hypothetical protein 5398177 1215239 SAV_4413 Streptomyces avermitilis MA-4680 hypothetical protein NP_825590.1 5397278 R 227882 CDS NP_825591.1 29830957 1215240 complement(5398569..5398967) 1 NC_003155.4 hypothetical protein 5398967 1215240 SAV_4414 Streptomyces avermitilis MA-4680 hypothetical protein NP_825591.1 5398569 R 227882 CDS NP_825592.1 29830958 1215241 5399204..5400463 1 NC_003155.4 PF01933: Uncharacterised protein family UPF0052; membrane protein; magnesium or manganese-dependent protein phosphatase 5400463 prpB9 1215241 prpB9 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_825592.1 5399204 D 227882 CDS NP_825593.1 29830959 1215242 5400539..5401288 1 NC_003155.4 two-component system response regulator 5401288 1215242 SAV_4416 Streptomyces avermitilis MA-4680 two-component system response regulator NP_825593.1 5400539 D 227882 CDS NP_825594.1 29830960 1215243 5401291..5402415 1 NC_003155.4 two-component system sensor kinase 5402415 1215243 SAV_4417 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_825594.1 5401291 D 227882 CDS NP_825595.1 29830961 1215244 5402498..5403640 1 NC_003155.4 hypothetical protein 5403640 1215244 SAV_4418 Streptomyces avermitilis MA-4680 hypothetical protein NP_825595.1 5402498 D 227882 CDS NP_825596.1 29830962 1215245 complement(5403680..5405776) 1 NC_003155.4 hypothetical protein 5405776 1215245 SAV_4419 Streptomyces avermitilis MA-4680 hypothetical protein NP_825596.1 5403680 R 227882 CDS NP_825597.1 29830963 1215246 complement(5405854..5406009) 1 NC_003155.4 hypothetical protein 5406009 1215246 SAV_4420 Streptomyces avermitilis MA-4680 hypothetical protein NP_825597.1 5405854 R 227882 CDS NP_825598.1 29830964 1215247 5406164..5407507 1 NC_003155.4 regulatory protein 5407507 1215247 SAV_4421 Streptomyces avermitilis MA-4680 regulatory protein NP_825598.1 5406164 D 227882 CDS NP_825599.1 29830965 1215248 complement(5407822..5408043) 1 NC_003155.4 hypothetical protein 5408043 1215248 SAV_4422 Streptomyces avermitilis MA-4680 hypothetical protein NP_825599.1 5407822 R 227882 CDS NP_825600.1 29830966 1210988 complement(5408114..5409736) 1 NC_003155.4 PF00912: Transglycosylase; penicillin-binding protein 5409736 pbp7 1210988 pbp7 Streptomyces avermitilis MA-4680 penicillin-binding protein NP_825600.1 5408114 R 227882 CDS NP_825601.1 29830967 1215249 complement(5409733..5410407) 1 NC_003155.4 hypothetical protein 5410407 1215249 SAV_4424 Streptomyces avermitilis MA-4680 hypothetical protein NP_825601.1 5409733 R 227882 CDS NP_825602.1 29830968 1210989 complement(5410404..5410841) 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 5410841 sig38 1210989 sig38 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_825602.1 5410404 R 227882 CDS NP_825603.1 29830969 1215250 complement(5410838..5411599) 1 NC_003155.4 PF03734: ErfK/YbiS/YcfS/YnhG; hypothetical protein 5411599 1215250 SAV_4426 Streptomyces avermitilis MA-4680 hypothetical protein NP_825603.1 5410838 R 227882 CDS NP_825604.1 29830970 1210990 5411790..5412317 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 5412317 sig39 1210990 sig39 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_825604.1 5411790 D 227882 CDS NP_825605.1 29830971 1215251 5412370..5413092 1 NC_003155.4 PF03734: ErfK/YbiS/YcfS/YnhG; hypothetical protein 5413092 1215251 SAV_4428 Streptomyces avermitilis MA-4680 hypothetical protein NP_825605.1 5412370 D 227882 CDS NP_825606.1 29830972 1215252 5413105..5413407 1 NC_003155.4 hypothetical protein 5413407 1215252 SAV_4429 Streptomyces avermitilis MA-4680 hypothetical protein NP_825606.1 5413105 D 227882 CDS NP_825607.1 29830973 1215253 complement(5413657..5414040) 1 NC_003155.4 hypothetical protein 5414040 1215253 SAV_4430 Streptomyces avermitilis MA-4680 hypothetical protein NP_825607.1 5413657 R 227882 CDS NP_825608.1 29830974 1215254 complement(5414741..5415433) 1 NC_003155.4 hypothetical protein 5415433 1215254 SAV_4431 Streptomyces avermitilis MA-4680 hypothetical protein NP_825608.1 5414741 R 227882 CDS NP_825609.1 29830975 1215255 complement(5415734..5418052) 1 NC_003155.4 PF00400: WD domain, G-beta repeat; beta transducin-like protein 5418052 1215255 SAV_4432 Streptomyces avermitilis MA-4680 beta transducin-like protein NP_825609.1 5415734 R 227882 CDS NP_825610.1 29830976 1215256 complement(5418049..5420319) 1 NC_003155.4 hypothetical protein 5420319 1215256 SAV_4433 Streptomyces avermitilis MA-4680 hypothetical protein NP_825610.1 5418049 R 227882 CDS NP_825611.1 29830977 1215257 5420456..5421829 1 NC_003155.4 PF02450: Lecithin:cholesterol acyltransferase; hypothetical protein 5421829 1215257 SAV_4434 Streptomyces avermitilis MA-4680 hypothetical protein NP_825611.1 5420456 D 227882 CDS NP_825612.1 29830978 1215258 5421978..5423018 1 NC_003155.4 hypothetical protein 5423018 1215258 SAV_4435 Streptomyces avermitilis MA-4680 hypothetical protein NP_825612.1 5421978 D 227882 CDS NP_825613.1 29830979 1215259 complement(5423150..5423887) 1 NC_003155.4 hypothetical protein 5423887 1215259 SAV_4436 Streptomyces avermitilis MA-4680 hypothetical protein NP_825613.1 5423150 R 227882 CDS NP_825614.1 29830980 1215260 5423925..5424692 1 NC_003155.4 hypothetical protein 5424692 1215260 SAV_4437 Streptomyces avermitilis MA-4680 hypothetical protein NP_825614.1 5423925 D 227882 CDS NP_825615.1 29830981 1215261 5424902..5425672 1 NC_003155.4 hypothetical protein 5425672 1215261 SAV_4438 Streptomyces avermitilis MA-4680 hypothetical protein NP_825615.1 5424902 D 227882 CDS NP_825616.1 29830982 1215262 5425825..5426880 1 NC_003155.4 permease 5426880 1215262 SAV_4439 Streptomyces avermitilis MA-4680 permease NP_825616.1 5425825 D 227882 CDS NP_825617.1 29830983 1215263 5426832..5427671 1 NC_003155.4 hypothetical protein 5427671 1215263 SAV_4440 Streptomyces avermitilis MA-4680 hypothetical protein NP_825617.1 5426832 D 227882 CDS NP_825618.1 29830984 1215264 complement(5427739..5428461) 1 NC_003155.4 hypothetical protein 5428461 1215264 SAV_4441 Streptomyces avermitilis MA-4680 hypothetical protein NP_825618.1 5427739 R 227882 CDS NP_825619.1 29830985 1215265 5428474..5429163 1 NC_003155.4 hypothetical protein 5429163 1215265 SAV_4442 Streptomyces avermitilis MA-4680 hypothetical protein NP_825619.1 5428474 D 227882 CDS NP_825620.2 162960849 1215266 complement(5429180..5430301) 1 NC_003155.4 IS630 family transposase 5430301 1215266 SAV_4443 Streptomyces avermitilis MA-4680 IS630 family transposase NP_825620.2 5429180 R 227882 CDS NP_825621.1 29830987 1215267 5430439..5431380 1 NC_003155.4 PF00702: haloacid dehalogenase-like hydrolase; hypothetical protein 5431380 1215267 SAV_4444 Streptomyces avermitilis MA-4680 hypothetical protein NP_825621.1 5430439 D 227882 CDS NP_825622.1 29830988 1215268 complement(5431462..5431839) 1 NC_003155.4 hypothetical protein 5431839 1215268 SAV_4445 Streptomyces avermitilis MA-4680 hypothetical protein NP_825622.1 5431462 R 227882 CDS NP_825623.1 29830989 1215269 complement(5431916..5433448) 1 NC_003155.4 PF00270: DEAD/DEAH box helicase; ATP-dependent RNA helicase 5433448 1215269 SAV_4446 Streptomyces avermitilis MA-4680 ATP-dependent RNA helicase NP_825623.1 5431916 R 227882 CDS NP_825624.1 29830990 1210991 complement(5433840..5434043) 1 NC_003155.4 cold shock protein 5434043 cspD4 1210991 cspD4 Streptomyces avermitilis MA-4680 cold shock protein NP_825624.1 5433840 R 227882 CDS NP_825625.1 29830991 1215270 complement(5434404..5434748) 1 NC_003155.4 MarR family transcriptional regulator 5434748 1215270 SAV_4448 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_825625.1 5434404 R 227882 CDS NP_825626.1 29830992 1215271 complement(5435200..5435382) 1 NC_003155.4 hypothetical protein 5435382 1215271 SAV_4449 Streptomyces avermitilis MA-4680 hypothetical protein NP_825626.1 5435200 R 227882 CDS NP_825627.1 29830993 1215272 5435482..5435955 1 NC_003155.4 hypothetical protein 5435955 1215272 SAV_4450 Streptomyces avermitilis MA-4680 hypothetical protein NP_825627.1 5435482 D 227882 CDS NP_825628.1 29830994 1215273 5436036..5436461 1 NC_003155.4 hypothetical protein 5436461 1215273 SAV_4451 Streptomyces avermitilis MA-4680 hypothetical protein NP_825628.1 5436036 D 227882 CDS NP_825629.1 29830995 1210992 5436525..5437490 1 NC_003155.4 PF00144: Beta-lactamase; beta-lactamase 5437490 blaA3 1210992 blaA3 Streptomyces avermitilis MA-4680 beta-lactamase NP_825629.1 5436525 D 227882 CDS NP_825630.1 29830996 1215274 5437523..5438674 1 NC_003155.4 two-component system sensor kinase 5438674 1215274 SAV_4453 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_825630.1 5437523 D 227882 CDS NP_825631.1 29830997 1215275 5438671..5439321 1 NC_003155.4 two-component system response regulator 5439321 1215275 SAV_4454 Streptomyces avermitilis MA-4680 two-component system response regulator NP_825631.1 5438671 D 227882 CDS NP_825632.1 29830998 1215276 5439435..5440601 1 NC_003155.4 PF00144: Beta-lactamase; beta-lactamase 5440601 1215276 SAV_4455 Streptomyces avermitilis MA-4680 beta-lactamase NP_825632.1 5439435 D 227882 CDS NP_825633.1 29830999 1215277 5440567..5440959 1 NC_003155.4 hypothetical protein 5440959 1215277 SAV_4456 Streptomyces avermitilis MA-4680 hypothetical protein NP_825633.1 5440567 D 227882 CDS NP_825634.1 29831000 1215278 complement(5440971..5442080) 1 NC_003155.4 PF06626: Protein of unknown function (DUF1152); hypothetical protein 5442080 1215278 SAV_4457 Streptomyces avermitilis MA-4680 hypothetical protein NP_825634.1 5440971 R 227882 CDS NP_825635.1 29831001 1215279 5442619..5442948 1 NC_003155.4 hypothetical protein 5442948 1215279 SAV_4458 Streptomyces avermitilis MA-4680 hypothetical protein NP_825635.1 5442619 D 227882 CDS NP_825636.1 29831002 1215280 5443230..5444921 1 NC_003155.4 PF01186: Lysyl oxidase; hypothetical protein 5444921 1215280 SAV_4459 Streptomyces avermitilis MA-4680 hypothetical protein NP_825636.1 5443230 D 227882 CDS NP_825637.1 29831003 1215281 5445508..5446695 1 NC_003155.4 hypothetical protein 5446695 1215281 SAV_4460 Streptomyces avermitilis MA-4680 hypothetical protein NP_825637.1 5445508 D 227882 CDS NP_825638.1 29831004 1215282 complement(5447060..5448367) 1 NC_003155.4 PF05257: CHAP domain; hypothetical protein 5448367 1215282 SAV_4461 Streptomyces avermitilis MA-4680 hypothetical protein NP_825638.1 5447060 R 227882 CDS NP_825639.1 29831005 1215283 5449474..5450733 1 NC_003155.4 PF03721: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-glucose/GDP-mannose dehydrogenase 5450733 wbpA 1215283 wbpA Streptomyces avermitilis MA-4680 UDP-glucose/GDP-mannose dehydrogenase NP_825639.1 5449474 D 227882 CDS NP_825640.1 29831006 1215284 5451109..5452428 1 NC_003155.4 similar to hyaluronate synthase, PF00535: Glycosyl transferase; glycosyl transferase 5452428 1215284 SAV_4463 Streptomyces avermitilis MA-4680 glycosyl transferase NP_825640.1 5451109 D 227882 CDS NP_825641.1 29831007 1210994 5453354..5453929 1 NC_003155.4 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 5453929 dcd 1210994 dcd Streptomyces avermitilis MA-4680 deoxycytidine triphosphate deaminase NP_825641.1 5453354 D 227882 CDS NP_825642.1 29831008 1210995 5453950..5454459 1 NC_003155.4 purine phosphoribosyltransferase 5454459 gptA 1210995 gptA Streptomyces avermitilis MA-4680 purine phosphoribosyltransferase NP_825642.1 5453950 D 227882 CDS NP_825643.1 29831009 1215285 complement(5455631..5456419) 1 NC_003155.4 IS1648-like transposase 5456419 1215285 SAV_4466 Streptomyces avermitilis MA-4680 IS1648-like transposase NP_825643.1 5455631 R 227882 CDS NP_825644.1 29831010 1215286 complement(5456416..5457267) 1 NC_003155.4 rRNA methyltransferase 5457267 1215286 SAV_4467 Streptomyces avermitilis MA-4680 rRNA methyltransferase NP_825644.1 5456416 R 227882 CDS NP_825645.1 29831011 1215287 complement(5457668..5459101) 1 NC_003155.4 PF07508: Recombinase; integrase/recombinase 5459101 int11 1215287 int11 Streptomyces avermitilis MA-4680 integrase/recombinase NP_825645.1 5457668 R 227882 CDS NP_825646.1 29831012 1215288 complement(5459306..5460319) 1 NC_003155.4 hypothetical protein 5460319 1215288 SAV_4469 Streptomyces avermitilis MA-4680 hypothetical protein NP_825646.1 5459306 R 227882 CDS NP_825647.1 29831013 1215289 complement(5460393..5460908) 1 NC_003155.4 regulatory protein 5460908 1215289 SAV_4470 Streptomyces avermitilis MA-4680 regulatory protein NP_825647.1 5460393 R 227882 CDS NP_825648.1 29831014 1215290 5460989..5461831 1 NC_003155.4 PF01381: Helix-turn-helix; DNA-binding protein 5461831 1215290 SAV_4471 Streptomyces avermitilis MA-4680 DNA-binding protein NP_825648.1 5460989 D 227882 CDS NP_825649.1 29831015 1215291 5461843..5462028 1 NC_003155.4 PF04149: Domain of unknown function (DUF397); hypothetical protein 5462028 1215291 SAV_4472 Streptomyces avermitilis MA-4680 hypothetical protein NP_825649.1 5461843 D 227882 CDS NP_825650.1 29831016 1215292 complement(5462069..5463505) 1 NC_003155.4 PF01839: FG-GAP repeat; integrin-like protein 5463505 1215292 SAV_4473 Streptomyces avermitilis MA-4680 integrin-like protein NP_825650.1 5462069 R 227882 CDS NP_825651.1 29831017 1215293 complement(5463525..5464970) 1 NC_003155.4 PF01839: FG-GAP repeat; integrin-like protein 5464970 1215293 SAV_4474 Streptomyces avermitilis MA-4680 integrin-like protein NP_825651.1 5463525 R 227882 CDS NP_825652.1 29831018 1215294 complement(5465049..5466422) 1 NC_003155.4 PF01839: FG-GAP repeat; integrin-like protein 5466422 1215294 SAV_4475 Streptomyces avermitilis MA-4680 integrin-like protein NP_825652.1 5465049 R 227882 CDS NP_825653.1 29831019 1215295 complement(5466471..5467916) 1 NC_003155.4 PF01839: FG-GAP repeat; integrin-like protein 5467916 1215295 SAV_4476 Streptomyces avermitilis MA-4680 integrin-like protein NP_825653.1 5466471 R 227882 CDS NP_825654.1 29831020 1215296 complement(5468142..5469623) 1 NC_003155.4 PF01839: FG-GAP repeat; integrin-like protein 5469623 1215296 SAV_4477 Streptomyces avermitilis MA-4680 integrin-like protein NP_825654.1 5468142 R 227882 CDS NP_825655.1 29831021 1215297 complement(5469949..5471394) 1 NC_003155.4 PF01839: FG-GAP repeat; integrin-like protein 5471394 1215297 SAV_4478 Streptomyces avermitilis MA-4680 integrin-like protein NP_825655.1 5469949 R 227882 CDS NP_825656.1 29831022 1215298 complement(5471488..5472954) 1 NC_003155.4 PF01839: FG-GAP repeat; integrin-like protein 5472954 1215298 SAV_4479 Streptomyces avermitilis MA-4680 integrin-like protein NP_825656.1 5471488 R 227882 CDS NP_825657.1 29831023 1215299 5473189..5473617 1 NC_003155.4 hypothetical protein 5473617 1215299 SAV_4480 Streptomyces avermitilis MA-4680 hypothetical protein NP_825657.1 5473189 D 227882 CDS NP_825658.1 29831024 1215300 complement(5473717..5475165) 1 NC_003155.4 PF02389: Cornifin (SPRR) family; hypothetical protein 5475165 1215300 SAV_4481 Streptomyces avermitilis MA-4680 hypothetical protein NP_825658.1 5473717 R 227882 CDS NP_825659.1 29831025 1215301 complement(5475393..5477660) 1 NC_003155.4 iron-sulphur-binding reductase 5477660 1215301 SAV_4482 Streptomyces avermitilis MA-4680 iron-sulphur-binding reductase NP_825659.1 5475393 R 227882 CDS NP_825660.1 29831026 1215302 5477906..5478958 1 NC_003155.4 PF00953: Glycosyl transferase; glycosyl transferase 5478958 1215302 SAV_4483 Streptomyces avermitilis MA-4680 glycosyl transferase NP_825660.1 5477906 D 227882 CDS NP_825661.1 29831027 1210996 5479054..5480922 1 NC_003155.4 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 5480922 dnaK 1210996 dnaK Streptomyces avermitilis MA-4680 molecular chaperone DnaK NP_825661.1 5479054 D 227882 CDS NP_825662.1 29831028 1210997 5480919..5481584 1 NC_003155.4 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 5481584 grpE1 1210997 grpE1 Streptomyces avermitilis MA-4680 heat shock protein GrpE NP_825662.1 5480919 D 227882 CDS NP_825663.1 29831029 1210998 5481621..5482811 1 NC_003155.4 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 5482811 dnaJ1 1210998 dnaJ1 Streptomyces avermitilis MA-4680 chaperone protein DnaJ NP_825663.1 5481621 D 227882 CDS NP_825664.1 29831030 1210999 5482816..5483265 1 NC_003155.4 repressor of dnaK operon; HspR protein 5483265 hspR 1210999 hspR Streptomyces avermitilis MA-4680 HspR protein NP_825664.1 5482816 D 227882 CDS NP_825665.1 29831031 1215303 5483746..5484882 1 NC_003155.4 sugar ABC transporter substrate-binding protein 5484882 1215303 SAV_4488 Streptomyces avermitilis MA-4680 sugar ABC transporter substrate-binding protein NP_825665.1 5483746 D 227882 CDS NP_825666.1 29831032 1215304 complement(5485086..5485415) 1 NC_003155.4 hypothetical protein 5485415 1215304 SAV_4489 Streptomyces avermitilis MA-4680 hypothetical protein NP_825666.1 5485086 R 227882 CDS NP_825667.1 29831033 1215305 complement(5485460..5487214) 1 NC_003155.4 PF02467: Transcription factor WhiB; hypothetical protein 5487214 1215305 SAV_4490 Streptomyces avermitilis MA-4680 hypothetical protein NP_825667.1 5485460 R 227882 CDS NP_825668.1 29831034 1215306 complement(5487162..5487797) 1 NC_003155.4 hypothetical protein 5487797 1215306 SAV_4491 Streptomyces avermitilis MA-4680 hypothetical protein NP_825668.1 5487162 R 227882 CDS NP_825669.1 29831035 1215307 complement(5487794..5489026) 1 NC_003155.4 hypothetical protein 5489026 1215307 SAV_4492 Streptomyces avermitilis MA-4680 hypothetical protein NP_825669.1 5487794 R 227882 CDS NP_825670.1 29831036 1215308 complement(5489023..5489739) 1 NC_003155.4 hypothetical protein 5489739 1215308 SAV_4493 Streptomyces avermitilis MA-4680 hypothetical protein NP_825670.1 5489023 R 227882 CDS NP_825671.1 29831037 1215309 complement(5489669..5490298) 1 NC_003155.4 hypothetical protein 5490298 1215309 SAV_4494 Streptomyces avermitilis MA-4680 hypothetical protein NP_825671.1 5489669 R 227882 CDS NP_825672.1 29831038 1215310 complement(5490512..5492782) 1 NC_003155.4 hypothetical protein 5492782 1215310 SAV_4495 Streptomyces avermitilis MA-4680 hypothetical protein NP_825672.1 5490512 R 227882 CDS NP_825673.1 29831039 1215311 complement(5492823..5493341) 1 NC_003155.4 hypothetical protein 5493341 1215311 SAV_4496 Streptomyces avermitilis MA-4680 hypothetical protein NP_825673.1 5492823 R 227882 CDS NP_825674.1 29831040 1215312 complement(5493352..5493963) 1 NC_003155.4 hypothetical protein 5493963 1215312 SAV_4497 Streptomyces avermitilis MA-4680 hypothetical protein NP_825674.1 5493352 R 227882 CDS NP_825675.1 29831041 1215313 complement(5493999..5496983) 1 NC_003155.4 hypothetical protein 5496983 1215313 SAV_4498 Streptomyces avermitilis MA-4680 hypothetical protein NP_825675.1 5493999 R 227882 CDS NP_825676.1 29831042 1215314 complement(5497036..5497533) 1 NC_003155.4 hypothetical protein 5497533 1215314 SAV_4499 Streptomyces avermitilis MA-4680 hypothetical protein NP_825676.1 5497036 R 227882 CDS NP_825677.1 29831043 1215315 complement(5497575..5497841) 1 NC_003155.4 hypothetical protein 5497841 1215315 SAV_4500 Streptomyces avermitilis MA-4680 hypothetical protein NP_825677.1 5497575 R 227882 CDS NP_825678.1 29831044 1215316 complement(5497917..5498972) 1 NC_003155.4 hypothetical protein 5498972 1215316 SAV_4502 Streptomyces avermitilis MA-4680 hypothetical protein NP_825678.1 5497917 R 227882 CDS NP_825679.1 29831045 1215317 5498944..5500545 1 NC_003155.4 hypothetical protein 5500545 1215317 SAV_4501 Streptomyces avermitilis MA-4680 hypothetical protein NP_825679.1 5498944 D 227882 CDS NP_825680.1 29831046 1215318 5500576..5501205 1 NC_003155.4 hypothetical protein 5501205 1215318 SAV_4503 Streptomyces avermitilis MA-4680 hypothetical protein NP_825680.1 5500576 D 227882 CDS NP_825681.1 29831047 1215319 5501202..5502227 1 NC_003155.4 hypothetical protein 5502227 1215319 SAV_4504 Streptomyces avermitilis MA-4680 hypothetical protein NP_825681.1 5501202 D 227882 CDS NP_825682.1 29831048 1215320 5502224..5502604 1 NC_003155.4 hypothetical protein 5502604 1215320 SAV_4505 Streptomyces avermitilis MA-4680 hypothetical protein NP_825682.1 5502224 D 227882 CDS NP_825683.1 29831049 1215321 5502822..5503505 1 NC_003155.4 hypothetical protein 5503505 1215321 SAV_4506 Streptomyces avermitilis MA-4680 hypothetical protein NP_825683.1 5502822 D 227882 CDS NP_825684.1 29831050 1215322 5503513..5505618 1 NC_003155.4 PF01551: Peptidase family M23; peptidase 5505618 1215322 SAV_4507 Streptomyces avermitilis MA-4680 peptidase NP_825684.1 5503513 D 227882 CDS NP_825685.1 29831051 1215323 5505620..5507065 1 NC_003155.4 PF01011: PQQ enzyme repeat; hypothetical protein 5507065 1215323 SAV_4508 Streptomyces avermitilis MA-4680 hypothetical protein NP_825685.1 5505620 D 227882 CDS NP_825686.1 29831052 1215324 5507102..5508832 1 NC_003155.4 conjugative transfer gene complex protein 5508832 trsK 1215324 trsK Streptomyces avermitilis MA-4680 conjugative transfer gene complex protein NP_825686.1 5507102 D 227882 CDS NP_825687.1 29831053 1215325 5509973..5511187 1 NC_003155.4 LuxR family transcriptional regulator 5511187 1215325 SAV_4510 Streptomyces avermitilis MA-4680 LuxR family transcriptional regulator NP_825687.1 5509973 D 227882 CDS NP_825688.1 29831054 1215326 complement(5511232..5512215) 1 NC_003155.4 LuxR family transcriptional regulator 5512215 1215326 SAV_4511 Streptomyces avermitilis MA-4680 LuxR family transcriptional regulator NP_825688.1 5511232 R 227882 CDS NP_825689.1 29831055 1215327 5512530..5512865 1 NC_003155.4 hypothetical protein 5512865 1215327 SAV_4512 Streptomyces avermitilis MA-4680 hypothetical protein NP_825689.1 5512530 D 227882 CDS NP_825690.1 29831056 1215328 complement(5513048..5513464) 1 NC_003155.4 PF01243: Pyridoxamine 5'-phosphate oxidase; hypothetical protein 5513464 1215328 SAV_4513 Streptomyces avermitilis MA-4680 hypothetical protein NP_825690.1 5513048 R 227882 CDS NP_825691.1 29831057 1211000 5513634..5516246 1 NC_003155.4 ATPases with chaperone activity, PF07724: ATPase family associated with various cellular activities (AAA); ATP-dependent Clp protease 5516246 clpB1 1211000 clpB1 Streptomyces avermitilis MA-4680 ATP-dependent Clp protease NP_825691.1 5513634 D 227882 CDS NP_825692.1 29831058 1215329 5516519..5517046 1 NC_003155.4 hypothetical protein 5517046 1215329 SAV_4515 Streptomyces avermitilis MA-4680 hypothetical protein NP_825692.1 5516519 D 227882 CDS NP_825693.1 29831059 1215330 complement(5517068..5518279) 1 NC_003155.4 PF04188: Protein of unknown function (DUF409); hypothetical protein 5518279 1215330 SAV_4516 Streptomyces avermitilis MA-4680 hypothetical protein NP_825693.1 5517068 R 227882 CDS NP_825694.1 29831060 1215331 complement(5518466..5519662) 1 NC_003155.4 aminotransferase 5519662 dapC 1215331 dapC Streptomyces avermitilis MA-4680 aminotransferase NP_825694.1 5518466 R 227882 CDS NP_825695.1 29831061 1215332 5520607..5521125 1 NC_003155.4 hypothetical protein 5521125 1215332 SAV_4518 Streptomyces avermitilis MA-4680 hypothetical protein NP_825695.1 5520607 D 227882 CDS NP_825696.1 29831062 1211001 5521235..5522881 1 NC_003155.4 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 5522881 speE 1211001 speE Streptomyces avermitilis MA-4680 spermidine synthase NP_825696.1 5521235 D 227882 CDS NP_825697.1 29831063 1215333 5522997..5523929 1 NC_003155.4 PF06240: Carbon monoxide dehydrogenase subunit G (CoxG); hypothetical protein 5523929 1215333 SAV_4520 Streptomyces avermitilis MA-4680 hypothetical protein NP_825697.1 5522997 D 227882 CDS NP_825698.1 29831064 1215334 5524053..5524841 1 NC_003155.4 PF01263: Aldose 1-epimerase; hypothetical protein 5524841 1215334 SAV_4521 Streptomyces avermitilis MA-4680 hypothetical protein NP_825698.1 5524053 D 227882 CDS NP_825699.1 29831065 1211002 5524875..5525423 1 NC_003155.4 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 5525423 pyrE 1211002 pyrE Streptomyces avermitilis MA-4680 orotate phosphoribosyltransferase NP_825699.1 5524875 D 227882 CDS NP_825700.1 29831066 1211003 5525590..5526612 1 NC_003155.4 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 5526612 fbaA 1211003 fbaA Streptomyces avermitilis MA-4680 fructose-bisphosphate aldolase NP_825700.1 5525590 D 227882 CDS NP_825701.1 29831067 1215335 5526702..5528291 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 5528291 1215335 SAV_4524 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_825701.1 5526702 D 227882 CDS NP_825702.1 29831068 1215336 5528433..5528846 1 NC_003155.4 hypothetical protein 5528846 1215336 SAV_4525 Streptomyces avermitilis MA-4680 hypothetical protein NP_825702.1 5528433 D 227882 CDS NP_825703.1 29831069 1211004 5529052..5529897 1 NC_003155.4 PF03301: Tryptophan 2,3-dioxygenase; tryptophan 2,3-dioxygenase 5529897 tdo 1211004 tdo Streptomyces avermitilis MA-4680 tryptophan 2,3-dioxygenase NP_825703.1 5529052 D 227882 CDS NP_825704.1 29831070 1215337 5529890..5531074 1 NC_003155.4 PF01053: Cys/Met metabolism PLP-dependent enzyme; hydrolase 5531074 1215337 SAV_4527 Streptomyces avermitilis MA-4680 hydrolase NP_825704.1 5529890 D 227882 CDS NP_825705.1 29831071 1215338 complement(5531090..5531443) 1 NC_003155.4 hypothetical protein 5531443 1215338 SAV_4528 Streptomyces avermitilis MA-4680 hypothetical protein NP_825705.1 5531090 R 227882 CDS NP_825706.1 29831072 1215339 complement(5531573..5533534) 1 NC_003155.4 PF00498: FHA domain; hypothetical protein 5533534 1215339 SAV_4529 Streptomyces avermitilis MA-4680 hypothetical protein NP_825706.1 5531573 R 227882 CDS NP_825707.1 29831073 1215340 complement(5533682..5534287) 1 NC_003155.4 TetR family transcriptional regulator 5534287 1215340 SAV_4530 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_825707.1 5533682 R 227882 CDS NP_825708.1 29831074 1215341 5534474..5535493 1 NC_003155.4 lipase/esterase 5535493 1215341 SAV_4531 Streptomyces avermitilis MA-4680 lipase/esterase NP_825708.1 5534474 D 227882 CDS NP_825709.1 29831075 1215342 5535768..5536859 1 NC_003155.4 PF06259: Domain of unknown function (DUF1023); hypothetical protein 5536859 1215342 SAV_4532 Streptomyces avermitilis MA-4680 hypothetical protein NP_825709.1 5535768 D 227882 CDS NP_825710.1 29831076 1215343 5536852..5538147 1 NC_003155.4 PF01757: Acyltransferase family; hypothetical protein 5538147 1215343 SAV_4533 Streptomyces avermitilis MA-4680 hypothetical protein NP_825710.1 5536852 D 227882 CDS NP_825711.1 29831077 1215344 5538158..5539612 1 NC_003155.4 two-component system sensor kinase 5539612 1215344 SAV_4534 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_825711.1 5538158 D 227882 CDS NP_825712.1 29831078 1215345 5539727..5540401 1 NC_003155.4 two-component system response regulator 5540401 1215345 SAV_4535 Streptomyces avermitilis MA-4680 two-component system response regulator NP_825712.1 5539727 D 227882 CDS NP_825713.1 29831079 1215346 5540582..5541961 1 NC_003155.4 two-component system sensor kinase 5541961 1215346 SAV_4536 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_825713.1 5540582 D 227882 CDS NP_825714.1 29831080 1215347 5541958..5542632 1 NC_003155.4 two-component system response regulator 5542632 1215347 SAV_4537 Streptomyces avermitilis MA-4680 two-component system response regulator NP_825714.1 5541958 D 227882 CDS NP_825715.1 29831081 1215348 5543067..5543252 1 NC_003155.4 PF04149: Domain of unknown function (DUF397); hypothetical protein 5543252 1215348 SAV_4538 Streptomyces avermitilis MA-4680 hypothetical protein NP_825715.1 5543067 D 227882 CDS NP_825716.1 29831082 1211005 5543376..5544593 1 NC_003155.4 CYP107P2; cytochrome P450 5544593 cyp20 1211005 cyp20 Streptomyces avermitilis MA-4680 cytochrome P450 NP_825716.1 5543376 D 227882 CDS NP_825717.1 29831083 1215349 complement(5544848..5546452) 1 NC_003155.4 ABC transporter permease 5546452 1215349 SAV_4540 Streptomyces avermitilis MA-4680 ABC transporter permease NP_825717.1 5544848 R 227882 CDS NP_825718.1 29831084 1215350 complement(5546449..5547363) 1 NC_003155.4 ABC transporter ATP-binding protein 5547363 1215350 SAV_4541 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_825718.1 5546449 R 227882 CDS NP_825719.1 29831085 1215351 5547552..5547962 1 NC_003155.4 PF01047: MarR family; hypothetical protein 5547962 1215351 SAV_4542 Streptomyces avermitilis MA-4680 hypothetical protein NP_825719.1 5547552 D 227882 CDS NP_825720.1 29831086 1215352 complement(5548088..5549590) 1 NC_003155.4 amino acid permease 5549590 1215352 SAV_4543 Streptomyces avermitilis MA-4680 amino acid permease NP_825720.1 5548088 R 227882 CDS NP_825721.1 29831087 1211006 5549845..5551239 1 NC_003155.4 ethanolamine ammonia-lyase large subunit 5551239 eutB 1211006 eutB Streptomyces avermitilis MA-4680 ethanolamine ammonia-lyase large subunit NP_825721.1 5549845 D 227882 CDS NP_825722.1 29831088 1211007 5551236..5552024 1 NC_003155.4 catalyzes the formation of acetaldehyde from ethanolamine; ethanolamine ammonia-lyase small subunit 5552024 eutC 1211007 eutC Streptomyces avermitilis MA-4680 ethanolamine ammonia-lyase small subunit NP_825722.1 5551236 D 227882 CDS NP_825723.1 29831089 1215353 complement(5552317..5553174) 1 NC_003155.4 hypothetical protein 5553174 1215353 SAV_4546 Streptomyces avermitilis MA-4680 hypothetical protein NP_825723.1 5552317 R 227882 CDS NP_825724.1 29831090 1211008 5553370..5554653 1 NC_003155.4 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 5554653 purA 1211008 purA Streptomyces avermitilis MA-4680 adenylosuccinate synthetase NP_825724.1 5553370 D 227882 CDS NP_825725.1 29831091 1215354 complement(5554881..5555531) 1 NC_003155.4 hypothetical protein 5555531 1215354 SAV_4548 Streptomyces avermitilis MA-4680 hypothetical protein NP_825725.1 5554881 R 227882 CDS NP_825726.1 29831092 1215355 complement(5555606..5558074) 1 NC_003155.4 PF00535: Glycosyl transferase; glycosyl transferase 5558074 1215355 SAV_4549 Streptomyces avermitilis MA-4680 glycosyl transferase NP_825726.1 5555606 R 227882 CDS NP_825727.1 29831093 1215356 complement(5558071..5558775) 1 NC_003155.4 GntR family transcriptional regulator 5558775 1215356 SAV_4550 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_825727.1 5558071 R 227882 CDS NP_825728.1 29831094 1215357 complement(5558978..5560333) 1 NC_003155.4 hypothetical protein 5560333 1215357 SAV_4551 Streptomyces avermitilis MA-4680 hypothetical protein NP_825728.1 5558978 R 227882 CDS NP_825729.1 29831095 1215358 5560534..5561136 1 NC_003155.4 PF01965: DJ-1/PfpI family; hypothetical protein 5561136 1215358 SAV_4552 Streptomyces avermitilis MA-4680 hypothetical protein NP_825729.1 5560534 D 227882 CDS NP_825730.1 29831096 1215359 5561133..5561588 1 NC_003155.4 MarR family transcriptional regulator 5561588 1215359 SAV_4553 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_825730.1 5561133 D 227882 CDS NP_825731.1 29831097 1211009 5561678..5563726 1 NC_003155.4 serine/threonine protein kinase 5563726 pkn14 1211009 pkn14 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_825731.1 5561678 D 227882 CDS NP_825732.1 29831098 1215360 complement(5563845..5564591) 1 NC_003155.4 hypothetical protein 5564591 1215360 SAV_4555 Streptomyces avermitilis MA-4680 hypothetical protein NP_825732.1 5563845 R 227882 CDS NP_825733.1 29831099 1215361 5564945..5565286 1 NC_003155.4 PF02575: Uncharacterised BCR, YbaB family COG0718; hypothetical protein 5565286 1215361 SAV_4556 Streptomyces avermitilis MA-4680 hypothetical protein NP_825733.1 5564945 D 227882 CDS NP_825734.1 29831100 1211010 5565399..5565998 1 NC_003155.4 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 5565998 recR 1211010 recR Streptomyces avermitilis MA-4680 recombination protein RecR NP_825734.1 5565399 D 227882 CDS NP_825735.1 29831101 1215362 5565991..5566650 1 NC_003155.4 hypothetical protein 5566650 1215362 SAV_4558 Streptomyces avermitilis MA-4680 hypothetical protein NP_825735.1 5565991 D 227882 CDS NP_825736.1 29831102 1211011 5567003..5568295 1 NC_003155.4 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP, in Bacillus, lysine sensitive; regulated by response to starvation.; aspartate kinase 5568295 lysC 1211011 lysC Streptomyces avermitilis MA-4680 aspartate kinase NP_825736.1 5567003 D 227882 CDS NP_825737.1 29831103 1211012 5568295..5569371 1 NC_003155.4 aspartate-semialdehyde dehydrogenase 5569371 asd1 1211012 asd1 Streptomyces avermitilis MA-4680 aspartate-semialdehyde dehydrogenase NP_825737.1 5568295 D 227882 CDS NP_825738.1 29831104 1211013 5569855..5570430 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 5570430 sig40 1211013 sig40 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_825738.1 5569855 D 227882 CDS NP_825739.1 29831105 1215363 5570427..5571629 1 NC_003155.4 hypothetical protein 5571629 1215363 SAV_4562 Streptomyces avermitilis MA-4680 hypothetical protein NP_825739.1 5570427 D 227882 CDS NP_825740.1 29831106 1215364 complement(5571715..5572542) 1 NC_003155.4 hypothetical protein 5572542 1215364 SAV_4563 Streptomyces avermitilis MA-4680 hypothetical protein NP_825740.1 5571715 R 227882 CDS NP_825741.1 29831107 1215365 complement(5572719..5574560) 1 NC_003155.4 PF00326: Prolyl oligopeptidase family; peptidase 5574560 1215365 SAV_4564 Streptomyces avermitilis MA-4680 peptidase NP_825741.1 5572719 R 227882 CDS NP_825742.1 29831108 1215366 complement(5574683..5576704) 1 NC_003155.4 PF02254: TrkA-N domain; hypothetical protein 5576704 1215366 SAV_4565 Streptomyces avermitilis MA-4680 hypothetical protein NP_825742.1 5574683 R 227882 CDS NP_825743.1 29831109 1215367 complement(5576837..5577484) 1 NC_003155.4 PF01638: Transcriptional regulator; hypothetical protein 5577484 1215367 SAV_4566 Streptomyces avermitilis MA-4680 hypothetical protein NP_825743.1 5576837 R 227882 CDS NP_825744.1 29831110 1215368 complement(5577789..5578559) 1 NC_003155.4 hypothetical protein 5578559 1215368 SAV_4567 Streptomyces avermitilis MA-4680 hypothetical protein NP_825744.1 5577789 R 227882 CDS NP_825745.1 29831111 1215369 complement(5578556..5579566) 1 NC_003155.4 permease 5579566 1215369 SAV_4568 Streptomyces avermitilis MA-4680 permease NP_825745.1 5578556 R 227882 CDS NP_825746.1 29831112 1215370 complement(5579758..5581179) 1 NC_003155.4 hypothetical protein 5581179 1215370 SAV_4569 Streptomyces avermitilis MA-4680 hypothetical protein NP_825746.1 5579758 R 227882 CDS NP_825747.1 29831113 1215371 5581246..5582550 1 NC_003155.4 PF00174: Oxidoreductase molybdopterin binding domain; hypothetical protein 5582550 1215371 SAV_4570 Streptomyces avermitilis MA-4680 hypothetical protein NP_825747.1 5581246 D 227882 CDS NP_825748.1 29831114 1215372 complement(5582954..5583853) 1 NC_003155.4 PF05724: Thiopurine S-methyltransferase (TPMT); hypothetical protein 5583853 1215372 SAV_4571 Streptomyces avermitilis MA-4680 hypothetical protein NP_825748.1 5582954 R 227882 CDS NP_825749.1 29831115 1215373 complement(5583850..5584467) 1 NC_003155.4 hypothetical protein 5584467 1215373 SAV_4572 Streptomyces avermitilis MA-4680 hypothetical protein NP_825749.1 5583850 R 227882 CDS NP_825750.1 29831116 1215374 complement(5584464..5585261) 1 NC_003155.4 glycosyltransferase 5585261 1215374 SAV_4573 Streptomyces avermitilis MA-4680 glycosyltransferase NP_825750.1 5584464 R 227882 CDS NP_825751.1 29831117 1211014 complement(5585503..5586504) 1 NC_003155.4 UDP-glucose 4-epimerase 5586504 galE2 1211014 galE2 Streptomyces avermitilis MA-4680 UDP-glucose 4-epimerase NP_825751.1 5585503 R 227882 CDS NP_825752.1 29831118 1215375 complement(5586743..5588008) 1 NC_003155.4 PF00082: Subtilase family; serine protease 5588008 1215375 SAV_4575 Streptomyces avermitilis MA-4680 serine protease NP_825752.1 5586743 R 227882 CDS NP_825753.1 29831119 1215376 complement(5588005..5589681) 1 NC_003155.4 hypothetical protein 5589681 1215376 SAV_4576 Streptomyces avermitilis MA-4680 hypothetical protein NP_825753.1 5588005 R 227882 CDS NP_825754.1 29831120 1215377 complement(5589742..5590305) 1 NC_003155.4 hypothetical protein 5590305 1215377 SAV_4577 Streptomyces avermitilis MA-4680 hypothetical protein NP_825754.1 5589742 R 227882 CDS NP_825755.1 29831121 1215378 5590803..5591261 1 NC_003155.4 hypothetical protein 5591261 1215378 SAV_4578 Streptomyces avermitilis MA-4680 hypothetical protein NP_825755.1 5590803 D 227882 CDS NP_825756.1 29831122 1215379 5591261..5593192 1 NC_003155.4 PF06259: Domain of unknown function (DUF1023); hypothetical protein 5593192 1215379 SAV_4579 Streptomyces avermitilis MA-4680 hypothetical protein NP_825756.1 5591261 D 227882 CDS NP_825757.1 29831123 1215380 complement(5594588..5595373) 1 NC_003155.4 hypothetical protein 5595373 1215380 SAV_4580 Streptomyces avermitilis MA-4680 hypothetical protein NP_825757.1 5594588 R 227882 CDS NP_825758.1 29831124 1215381 complement(5595461..5596387) 1 NC_003155.4 PF00149: Calcineurin-like phosphoesterase; hypothetical protein 5596387 1215381 SAV_4581 Streptomyces avermitilis MA-4680 hypothetical protein NP_825758.1 5595461 R 227882 CDS NP_825759.1 29831125 1215382 5596519..5596986 1 NC_003155.4 PF02637: GatB/Yqey domain; hypothetical protein 5596986 1215382 SAV_4582 Streptomyces avermitilis MA-4680 hypothetical protein NP_825759.1 5596519 D 227882 CDS NP_825760.1 29831126 1211016 complement(5597046..5599337) 1 NC_003155.4 PF00912: Transglycosylase; penicillin-binding protein 5599337 pbp8 1211016 pbp8 Streptomyces avermitilis MA-4680 penicillin-binding protein NP_825760.1 5597046 R 227882 CDS NP_825761.1 29831127 1211017 5599696..5600085 1 NC_003155.4 PF02467: Transcription factor WhiB; WhiB-family transcriptional regulator 5600085 wblA 1211017 wblA Streptomyces avermitilis MA-4680 WhiB-family transcriptional regulator NP_825761.1 5599696 D 227882 CDS NP_825762.1 29831128 1215383 complement(5600160..5601584) 1 NC_003155.4 PF02374: Anion-transporting ATPase; ion-transporting ATPase 5601584 1215383 SAV_4585 Streptomyces avermitilis MA-4680 ion-transporting ATPase NP_825762.1 5600160 R 227882 CDS NP_825763.1 29831129 1215384 complement(5601581..5602558) 1 NC_003155.4 PF02374: Anion-transporting ATPase; ion-transporting ATPase 5602558 1215384 SAV_4586 Streptomyces avermitilis MA-4680 ion-transporting ATPase NP_825763.1 5601581 R 227882 CDS NP_825764.1 29831130 1215385 5602654..5602815 1 NC_003155.4 hypothetical protein 5602815 1215385 SAV_4587 Streptomyces avermitilis MA-4680 hypothetical protein NP_825764.1 5602654 D 227882 CDS NP_825765.1 29831131 1215386 5602812..5603282 1 NC_003155.4 PF01042: Endoribonuclease L-PSP; hypothetical protein 5603282 1215386 SAV_4588 Streptomyces avermitilis MA-4680 hypothetical protein NP_825765.1 5602812 D 227882 CDS NP_825766.1 29831132 1215387 5603487..5604359 1 NC_003155.4 PF00293: NUDIX domain; hypothetical protein 5604359 1215387 SAV_4589 Streptomyces avermitilis MA-4680 hypothetical protein NP_825766.1 5603487 D 227882 CDS NP_825767.1 29831133 1215388 5604356..5605186 1 NC_003155.4 PF00753: Metallo-beta-lactamase superfamily; hydrolase 5605186 1215388 SAV_4590 Streptomyces avermitilis MA-4680 hydrolase NP_825767.1 5604356 D 227882 CDS NP_825768.1 29831134 1215389 complement(5605260..5606171) 1 NC_003155.4 PF01909: Nucleotidyltransferase domain; hypothetical protein 5606171 1215389 SAV_4591 Streptomyces avermitilis MA-4680 hypothetical protein NP_825768.1 5605260 R 227882 CDS NP_825769.1 29831135 1215390 complement(5606198..5606872) 1 NC_003155.4 transcriptional regulator 5606872 1215390 SAV_4592 Streptomyces avermitilis MA-4680 transcriptional regulator NP_825769.1 5606198 R 227882 CDS NP_825770.1 29831136 1211018 5607216..5608148 1 NC_003155.4 endonuclease III 5608148 nth 1211018 nth Streptomyces avermitilis MA-4680 endonuclease III NP_825770.1 5607216 D 227882 CDS NP_825771.1 29831137 1215391 5608210..5608977 1 NC_003155.4 PF00293: NUDIX domain; hypothetical protein 5608977 1215391 SAV_4594 Streptomyces avermitilis MA-4680 hypothetical protein NP_825771.1 5608210 D 227882 CDS NP_825772.1 29831138 1215392 5609098..5610297 1 NC_003155.4 PF00089: Trypsin; serine protease 5610297 1215392 SAV_4595 Streptomyces avermitilis MA-4680 serine protease NP_825772.1 5609098 D 227882 CDS NP_825773.1 29831139 1215393 complement(5610647..5611597) 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 5611597 1215393 SAV_4596 Streptomyces avermitilis MA-4680 hydrolase NP_825773.1 5610647 R 227882 CDS NP_825774.1 29831140 1215394 complement(5611594..5612070) 1 NC_003155.4 PF07332: Protein of unknown function (DUF1469); hypothetical protein 5612070 1215394 SAV_4597 Streptomyces avermitilis MA-4680 hypothetical protein NP_825774.1 5611594 R 227882 CDS NP_825775.1 29831141 1215395 complement(5612114..5613514) 1 NC_003155.4 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 5613514 nhaA 1215395 nhaA Streptomyces avermitilis MA-4680 pH-dependent sodium/proton antiporter NP_825775.1 5612114 R 227882 CDS NP_825776.1 29831142 1211019 complement(5613747..5615705) 1 NC_003155.4 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase 5615705 acsA1 1211019 acsA1 Streptomyces avermitilis MA-4680 acetyl-CoA synthetase NP_825776.1 5613747 R 227882 CDS NP_825777.1 29831143 1215396 complement(5616032..5618407) 1 NC_003155.4 PF00916: Sulfate transporter family; hypothetical protein 5618407 1215396 SAV_4600 Streptomyces avermitilis MA-4680 hypothetical protein NP_825777.1 5616032 R 227882 CDS NP_825778.1 29831144 1215397 5618725..5619996 1 NC_003155.4 hypothetical protein 5619996 1215397 SAV_4601 Streptomyces avermitilis MA-4680 hypothetical protein NP_825778.1 5618725 D 227882 CDS NP_825779.1 29831145 1215398 complement(5619986..5620975) 1 NC_003155.4 PF01656: CobQ/CobB/MinD/ParA nucleotide binding domain; carbon monoxide dehydrogenase accessory protein 5620975 cooC 1215398 cooC Streptomyces avermitilis MA-4680 carbon monoxide dehydrogenase accessory protein NP_825779.1 5619986 R 227882 CDS NP_825780.1 29831146 1215399 5621068..5621892 1 NC_003155.4 hypothetical protein 5621892 1215399 SAV_4603 Streptomyces avermitilis MA-4680 hypothetical protein NP_825780.1 5621068 D 227882 CDS NP_825781.1 29831147 1215400 complement(5622286..5623119) 1 NC_003155.4 morphological differentiation-associated protein 5623119 ssgB 1215400 ssgB Streptomyces avermitilis MA-4680 morphological differentiation-associated protein NP_825781.1 5622286 R 227882 CDS NP_825782.1 29831148 1211020 5623699..5624793 1 NC_003155.4 PF01656: CobQ/CobB/MinD/ParA nucleotide binding domain; septum site determining protein 5624793 minD2 1211020 minD2 Streptomyces avermitilis MA-4680 septum site determining protein NP_825782.1 5623699 D 227882 CDS NP_825783.1 29831149 1215401 5624790..5626091 1 NC_003155.4 PF00437: Type II/IV secretion system protein; hypothetical protein 5626091 1215401 SAV_4606 Streptomyces avermitilis MA-4680 hypothetical protein NP_825783.1 5624790 D 227882 CDS NP_825784.1 29831150 1215402 5626372..5627001 1 NC_003155.4 PF00482: Bacterial type II secretion system protein F domain; hypothetical protein 5627001 1215402 SAV_4607 Streptomyces avermitilis MA-4680 hypothetical protein NP_825784.1 5626372 D 227882 CDS NP_825785.1 29831151 1215403 5626998..5627498 1 NC_003155.4 hypothetical protein 5627498 1215403 SAV_4608 Streptomyces avermitilis MA-4680 hypothetical protein NP_825785.1 5626998 D 227882 CDS NP_825786.1 29831152 1215404 5627482..5627787 1 NC_003155.4 hypothetical protein 5627787 1215404 SAV_4609 Streptomyces avermitilis MA-4680 hypothetical protein NP_825786.1 5627482 D 227882 CDS NP_825787.1 29831153 1215405 5627907..5628140 1 NC_003155.4 hypothetical protein 5628140 1215405 SAV_4610 Streptomyces avermitilis MA-4680 hypothetical protein NP_825787.1 5627907 D 227882 CDS NP_825788.1 29831154 1215406 5628127..5628567 1 NC_003155.4 hypothetical protein 5628567 1215406 SAV_4611 Streptomyces avermitilis MA-4680 hypothetical protein NP_825788.1 5628127 D 227882 CDS NP_825789.1 29831155 1215407 5628315..5629013 1 NC_003155.4 hypothetical protein 5629013 1215407 SAV_4612 Streptomyces avermitilis MA-4680 hypothetical protein NP_825789.1 5628315 D 227882 CDS NP_825790.1 29831156 1215408 complement(5629010..5631517) 1 NC_003155.4 PF00270: DEAD/DEAH box helicase; ATP-dependent RNA helicase 5631517 1215408 SAV_4613 Streptomyces avermitilis MA-4680 ATP-dependent RNA helicase NP_825790.1 5629010 R 227882 CDS NP_825791.1 29831157 1211021 5631598..5631939 1 NC_003155.4 PF01740: STAS domain; anti-sigma factor antagonist 5631939 rsbV 1211021 rsbV Streptomyces avermitilis MA-4680 anti-sigma factor antagonist NP_825791.1 5631598 D 227882 CDS NP_825792.1 29831158 1215409 5632069..5632509 1 NC_003155.4 anti-sigma factor 5632509 1215409 SAV_4615 Streptomyces avermitilis MA-4680 anti-sigma factor NP_825792.1 5632069 D 227882 CDS NP_825793.1 29831159 1215410 5632824..5635229 1 NC_003155.4 pyrophosphate-energized proton pump; pyrophosphate-energized inorganic pyrophosphatase; H+-PPase; can cleave pyrophosphate to two phosphates; can generate a proton motive force and drive pyrophosphate synthesis when PMF is sufficient; membrane-bound proton-translocating pyrophosphatase 5635229 hppA 1215410 hppA Streptomyces avermitilis MA-4680 membrane-bound proton-translocating pyrophosphatase NP_825793.1 5632824 D 227882 CDS NP_825794.1 29831160 1215411 5635446..5636042 1 NC_003155.4 hypothetical protein 5636042 1215411 SAV_4617 Streptomyces avermitilis MA-4680 hypothetical protein NP_825794.1 5635446 D 227882 CDS NP_825795.1 29831161 1215412 5636158..5637747 1 NC_003155.4 rRNA or tRNA methyltransferase 5637747 1215412 SAV_4618 Streptomyces avermitilis MA-4680 rRNA or tRNA methyltransferase NP_825795.1 5636158 D 227882 CDS NP_825796.1 29831162 1211022 5637938..5640166 1 NC_003155.4 serine/threonine protein kinase 5640166 pkn15 1211022 pkn15 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_825796.1 5637938 D 227882 CDS NP_825797.1 29831163 1215413 5640163..5640504 1 NC_003155.4 hypothetical protein 5640504 1215413 SAV_4620 Streptomyces avermitilis MA-4680 hypothetical protein NP_825797.1 5640163 D 227882 CDS NP_825798.1 29831164 1211023 5640787..5643615 1 NC_003155.4 PF01131: DNA topoisomerase; DNA topoisomerase I 5643615 topA 1211023 topA Streptomyces avermitilis MA-4680 DNA topoisomerase I NP_825798.1 5640787 D 227882 CDS NP_825799.1 29831165 1211024 5643834..5647055 1 NC_003155.4 PF02223: Thymidylate kinase; thymidylate kinase 5647055 tmk 1211024 tmk Streptomyces avermitilis MA-4680 thymidylate kinase NP_825799.1 5643834 D 227882 CDS NP_825800.1 29831166 1211025 5647265..5648470 1 NC_003155.4 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 5648470 holB 1211025 holB Streptomyces avermitilis MA-4680 DNA polymerase III subunit delta' NP_825800.1 5647265 D 227882 CDS NP_825801.1 29831167 1211026 5648606..5650207 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; protease 5650207 slpD 1211026 slpD Streptomyces avermitilis MA-4680 protease NP_825801.1 5648606 D 227882 CDS NP_825802.1 29831168 1215414 complement(5650089..5651111) 1 NC_003155.4 integrated tRNA gene, PF00589: Phage integrase family; integrase/recombinase 5651111 int12 1215414 int12 Streptomyces avermitilis MA-4680 integrase/recombinase NP_825802.1 5650089 R 227882 CDS NP_825803.1 29831169 1215415 5651093..5651473 1 NC_003155.4 hypothetical protein 5651473 1215415 SAV_4625 Streptomyces avermitilis MA-4680 hypothetical protein NP_825803.1 5651093 D 227882 CDS NP_825804.1 29831170 1215416 complement(5651778..5652002) 1 NC_003155.4 hypothetical protein 5652002 1215416 SAV_4627 Streptomyces avermitilis MA-4680 hypothetical protein NP_825804.1 5651778 R 227882 CDS NP_825805.1 29831171 1215417 complement(5652810..5653526) 1 NC_003155.4 PF01590: GAF domain; hypothetical protein 5653526 1215417 SAV_4628 Streptomyces avermitilis MA-4680 hypothetical protein NP_825805.1 5652810 R 227882 CDS NP_825806.1 29831172 1215418 complement(5653610..5654485) 1 NC_003155.4 PF03861: ANTAR domain; hypothetical protein 5654485 1215418 SAV_4629 Streptomyces avermitilis MA-4680 hypothetical protein NP_825806.1 5653610 R 227882 CDS NP_825807.1 29831173 1215419 complement(5654485..5655219) 1 NC_003155.4 hypothetical protein 5655219 1215419 SAV_4630 Streptomyces avermitilis MA-4680 hypothetical protein NP_825807.1 5654485 R 227882 CDS NP_825808.1 29831174 1215420 complement(5655894..5656178) 1 NC_003155.4 PF03861: ANTAR domain; hypothetical protein 5656178 1215420 SAV_4631 Streptomyces avermitilis MA-4680 hypothetical protein NP_825808.1 5655894 R 227882 CDS NP_825809.1 29831175 1215421 complement(5656369..5656707) 1 NC_003155.4 hypothetical protein 5656707 1215421 SAV_4632 Streptomyces avermitilis MA-4680 hypothetical protein NP_825809.1 5656369 R 227882 CDS NP_825810.1 29831176 1215422 5657322..5657666 1 NC_003155.4 hypothetical protein 5657666 1215422 SAV_4633 Streptomyces avermitilis MA-4680 hypothetical protein NP_825810.1 5657322 D 227882 CDS NP_825811.1 29831177 1215423 5658328..5659263 1 NC_003155.4 glycosyltransferase 5659263 1215423 SAV_4634 Streptomyces avermitilis MA-4680 glycosyltransferase NP_825811.1 5658328 D 227882 CDS NP_825812.1 29831178 1215424 5659480..5662893 1 NC_003155.4 similar to AfsR, PF03704: Bacterial transcriptional activator domain; transcriptional regulator 5662893 1215424 SAV_4635 Streptomyces avermitilis MA-4680 transcriptional regulator NP_825812.1 5659480 D 227882 CDS NP_825813.1 29831179 1211028 complement(5662853..5664547) 1 NC_003155.4 DNA polymerase I 5664547 polA2 1211028 polA2 Streptomyces avermitilis MA-4680 DNA polymerase I NP_825813.1 5662853 R 227882 CDS NP_825814.1 29831180 1211029 complement(5664626..5665315) 1 NC_003155.4 ClpX protein 5665315 clpX1 1211029 clpX1 Streptomyces avermitilis MA-4680 ClpX protein NP_825814.1 5664626 R 227882 CDS NP_825815.1 29831181 1215425 5665530..5666657 1 NC_003155.4 hypothetical protein 5666657 1215425 SAV_4638 Streptomyces avermitilis MA-4680 hypothetical protein NP_825815.1 5665530 D 227882 CDS NP_825816.1 29831182 1215426 complement(5666668..5667186) 1 NC_003155.4 hypothetical protein 5667186 1215426 SAV_4639 Streptomyces avermitilis MA-4680 hypothetical protein NP_825816.1 5666668 R 227882 CDS NP_825817.1 29831183 1215427 complement(5667649..5668158) 1 NC_003155.4 PF05481: Mycobacterium 19 kDa lipoprotein antigen; hypothetical protein 5668158 1215427 SAV_4640 Streptomyces avermitilis MA-4680 hypothetical protein NP_825817.1 5667649 R 227882 CDS NP_825818.1 29831184 1211030 complement(5668223..5668528) 1 NC_003155.4 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 5668528 rpsN 1211030 rpsN Streptomyces avermitilis MA-4680 30S ribosomal protein S14 NP_825818.1 5668223 R 227882 CDS NP_825819.1 29831185 1211031 complement(5668528..5668749) 1 NC_003155.4 required for 70S ribosome assembly; 50S ribosomal protein L28 5668749 rpmB 1211031 rpmB Streptomyces avermitilis MA-4680 50S ribosomal protein L28 NP_825819.1 5668528 R 227882 CDS NP_825820.1 29831186 1211032 5668835..5668999 1 NC_003155.4 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 5668999 rpmG 1211032 rpmG Streptomyces avermitilis MA-4680 50S ribosomal protein L33 NP_825820.1 5668835 D 227882 CDS NP_825821.1 29831187 1211033 5669005..5669253 1 NC_003155.4 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 type B 5669253 rpmE2 1211033 rpmE2 Streptomyces avermitilis MA-4680 50S ribosomal protein L31 type B NP_825821.1 5669005 D 227882 CDS NP_825822.1 29831188 1215428 5669258..5670601 1 NC_003155.4 PF07683: Cobalamin synthesis protein cobW C-terminal domain; hypothetical protein 5670601 1215428 SAV_4645 Streptomyces avermitilis MA-4680 hypothetical protein NP_825822.1 5669258 D 227882 CDS NP_825823.1 29831189 1211034 5670601..5670837 1 NC_003155.4 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 5670837 rpsR2 1211034 rpsR2 Streptomyces avermitilis MA-4680 30S ribosomal protein S18 NP_825823.1 5670601 D 227882 CDS NP_825824.1 29831190 1215429 5671432..5671653 1 NC_003155.4 regulatory protein 5671653 1215429 SAV_4647 Streptomyces avermitilis MA-4680 regulatory protein NP_825824.1 5671432 D 227882 CDS NP_825825.1 29831191 1215430 complement(5671774..5672298) 1 NC_003155.4 regulatory protein 5672298 1215430 SAV_4648 Streptomyces avermitilis MA-4680 regulatory protein NP_825825.1 5671774 R 227882 CDS NP_825826.1 29831192 1215431 5672654..5673478 1 NC_003155.4 DNA-binding protein 5673478 1215431 SAV_4649 Streptomyces avermitilis MA-4680 DNA-binding protein NP_825826.1 5672654 D 227882 CDS NP_825827.1 29831193 1215432 5673611..5675071 1 NC_003155.4 PF00171: Aldehyde dehydrogenase family; aldehyde dehydrogenase 5675071 1215432 SAV_4650 Streptomyces avermitilis MA-4680 aldehyde dehydrogenase NP_825827.1 5673611 D 227882 CDS NP_825828.1 29831194 1215433 5675271..5675810 1 NC_003155.4 PF04978: Protein of unknown function (DUF664); hypothetical protein 5675810 1215433 SAV_4651 Streptomyces avermitilis MA-4680 hypothetical protein NP_825828.1 5675271 D 227882 CDS NP_825829.1 29831195 1215434 5675835..5676476 1 NC_003155.4 transcriptional regulator 5676476 1215434 SAV_4652 Streptomyces avermitilis MA-4680 transcriptional regulator NP_825829.1 5675835 D 227882 CDS NP_825830.1 29831196 1215435 5676565..5677497 1 NC_003155.4 ABC transporter ATP-binding protein 5677497 1215435 SAV_4653 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_825830.1 5676565 D 227882 CDS NP_825831.1 29831197 1215436 5677515..5678276 1 NC_003155.4 hypothetical protein 5678276 1215436 SAV_4654 Streptomyces avermitilis MA-4680 hypothetical protein NP_825831.1 5677515 D 227882 CDS NP_825832.1 29831198 1211035 complement(5678301..5679713) 1 NC_003155.4 PF00282: Pyridoxal-dependent decarboxylase conserved domain; glutamate decarboxylase 5679713 gadB2 1211035 gadB2 Streptomyces avermitilis MA-4680 glutamate decarboxylase NP_825832.1 5678301 R 227882 CDS NP_825833.1 29831199 1215437 complement(5679747..5681030) 1 NC_003155.4 PF00654: Voltage gated chloride channel; hypothetical protein 5681030 1215437 SAV_4656 Streptomyces avermitilis MA-4680 hypothetical protein NP_825833.1 5679747 R 227882 CDS NP_825834.1 29831200 1211036 5681130..5681891 1 NC_003155.4 MerR family transcriptional regulator 5681891 tipA 1211036 tipA Streptomyces avermitilis MA-4680 MerR family transcriptional regulator NP_825834.1 5681130 D 227882 CDS NP_825835.1 29831201 1215438 complement(5681955..5682320) 1 NC_003155.4 PF01906: Domain of unknown function DUF74; hypothetical protein 5682320 1215438 SAV_4658 Streptomyces avermitilis MA-4680 hypothetical protein NP_825835.1 5681955 R 227882 CDS NP_825836.1 29831202 1215439 5682461..5683480 1 NC_003155.4 PF00597: DedA family; hypothetical protein 5683480 1215439 SAV_4659 Streptomyces avermitilis MA-4680 hypothetical protein NP_825836.1 5682461 D 227882 CDS NP_825837.1 29831203 1215440 complement(5683583..5685244) 1 NC_003155.4 PF06738: Protein of unknown function (DUF1212); hypothetical protein 5685244 1215440 SAV_4660 Streptomyces avermitilis MA-4680 hypothetical protein NP_825837.1 5683583 R 227882 CDS NP_825838.1 29831204 1211037 complement(5685377..5685868) 1 NC_003155.4 inorganic pyrophosphatase 5685868 ppa 1211037 ppa Streptomyces avermitilis MA-4680 inorganic pyrophosphatase NP_825838.1 5685377 R 227882 CDS NP_825839.1 29831205 1215441 5686245..5687630 1 NC_003155.4 PF00768: D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase 5687630 dacE 1215441 dacE Streptomyces avermitilis MA-4680 D-alanyl-D-alanine carboxypeptidase NP_825839.1 5686245 D 227882 CDS NP_825840.1 29831206 1215442 5687726..5688859 1 NC_003155.4 hypothetical protein 5688859 1215442 SAV_4663 Streptomyces avermitilis MA-4680 hypothetical protein NP_825840.1 5687726 D 227882 CDS NP_825841.1 29831207 1215443 5689055..5690092 1 NC_003155.4 PF01171: PP-loop family; cell cycle protein 5690092 mesJ 1215443 mesJ Streptomyces avermitilis MA-4680 cell cycle protein NP_825841.1 5689055 D 227882 CDS NP_825842.1 29831208 1211038 5690146..5690706 1 NC_003155.4 hypoxanthine phosphoribosyltransferase 5690706 hprT 1211038 hprT Streptomyces avermitilis MA-4680 hypoxanthine phosphoribosyltransferase NP_825842.1 5690146 D 227882 CDS NP_825843.1 29831209 1211039 5690937..5692931 1 NC_003155.4 cell division protein FtsH 5692931 ftsH 1211039 ftsH Streptomyces avermitilis MA-4680 cell division protein FtsH NP_825843.1 5690937 D 227882 CDS NP_825844.1 29831210 1211040 5693074..5693679 1 NC_003155.4 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 5693679 folE 1211040 folE Streptomyces avermitilis MA-4680 GTP cyclohydrolase I NP_825844.1 5693074 D 227882 CDS NP_825845.1 29831211 1215444 complement(5693728..5694216) 1 NC_003155.4 hypothetical protein 5694216 1215444 SAV_4668 Streptomyces avermitilis MA-4680 hypothetical protein NP_825845.1 5693728 R 227882 CDS NP_825846.1 29831212 1211041 complement(5694270..5694881) 1 NC_003155.4 folic acid biosynthesis; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 5694881 folK 1211041 folK Streptomyces avermitilis MA-4680 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase NP_825846.1 5694270 R 227882 CDS NP_825847.1 29831213 1211042 complement(5694878..5695237) 1 NC_003155.4 folic acid biosynthesis; dihydroneopterin aldolase 5695237 folX 1211042 folX Streptomyces avermitilis MA-4680 dihydroneopterin aldolase NP_825847.1 5694878 R 227882 CDS NP_825848.1 29831214 1215445 complement(5695508..5696017) 1 NC_003155.4 hypothetical protein 5696017 1215445 SAV_4671 Streptomyces avermitilis MA-4680 hypothetical protein NP_825848.1 5695508 R 227882 CDS NP_825849.1 29831215 1211043 complement(5696014..5696946) 1 NC_003155.4 folic acid biosynthesis; dihydropteroate synthase 5696946 folP2 1211043 folP2 Streptomyces avermitilis MA-4680 dihydropteroate synthase NP_825849.1 5696014 R 227882 CDS NP_825850.1 29831216 1215446 complement(5697154..5698959) 1 NC_003155.4 PF04329: Family of unknown function (DUF470); hypothetical protein 5698959 1215446 SAV_4673 Streptomyces avermitilis MA-4680 hypothetical protein NP_825850.1 5697154 R 227882 CDS NP_825851.1 29831217 1215447 5699189..5700319 1 NC_003155.4 PF00756: Putative esterase; hypothetical protein 5700319 1215447 SAV_4674 Streptomyces avermitilis MA-4680 hypothetical protein NP_825851.1 5699189 D 227882 CDS NP_825852.1 29831218 1215448 5700632..5702176 1 NC_003155.4 hypothetical protein 5702176 1215448 SAV_4675 Streptomyces avermitilis MA-4680 hypothetical protein NP_825852.1 5700632 D 227882 CDS NP_825853.1 29831219 1215449 complement(5702276..5703649) 1 NC_003155.4 PF03703: Bacterial membrane flanked domain; hypothetical protein 5703649 1215449 SAV_4676 Streptomyces avermitilis MA-4680 hypothetical protein NP_825853.1 5702276 R 227882 CDS NP_825854.1 29831220 1215450 complement(5703664..5704185) 1 NC_003155.4 PF03703: Bacterial membrane flanked domain; integral membrane protein 5704185 1215450 SAV_4677 Streptomyces avermitilis MA-4680 integral membrane protein NP_825854.1 5703664 R 227882 CDS NP_825855.1 29831221 1211044 5704217..5705368 1 NC_003155.4 NADH dehydrogenase I chain D 5705368 nuoD2 1211044 nuoD2 Streptomyces avermitilis MA-4680 NADH dehydrogenase I chain D NP_825855.1 5704217 D 227882 CDS NP_825856.1 29831222 1215451 complement(5705333..5706391) 1 NC_003155.4 PF02636: Uncharacterized ACR, COG1565; hypothetical protein 5706391 1215451 SAV_4679 Streptomyces avermitilis MA-4680 hypothetical protein NP_825856.1 5705333 R 227882 CDS NP_825857.1 29831223 1215452 5706510..5707715 1 NC_003155.4 two-component system sensor kinase 5707715 1215452 SAV_4680 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_825857.1 5706510 D 227882 CDS NP_825858.1 29831224 1215453 5707796..5708467 1 NC_003155.4 two-component system response regulator 5708467 1215453 SAV_4681 Streptomyces avermitilis MA-4680 two-component system response regulator NP_825858.1 5707796 D 227882 CDS NP_825859.1 29831225 1215454 5708500..5709132 1 NC_003155.4 TmrB-like protein 5709132 1215454 SAV_4682 Streptomyces avermitilis MA-4680 TmrB-like protein NP_825859.1 5708500 D 227882 CDS NP_825860.1 29831226 1215455 complement(5709139..5710263) 1 NC_003155.4 transcription regulator ArsR 5710263 1215455 SAV_4683 Streptomyces avermitilis MA-4680 transcription regulator ArsR NP_825860.1 5709139 R 227882 CDS NP_825861.1 29831227 1215456 complement(5710565..5710693) 1 NC_003155.4 hypothetical protein 5710693 1215456 SAV_4684 Streptomyces avermitilis MA-4680 hypothetical protein NP_825861.1 5710565 R 227882 CDS NP_825862.1 29831228 1215457 complement(5710805..5712046) 1 NC_003155.4 L-allo-threonine aldolase 5712046 1215457 SAV_4685 Streptomyces avermitilis MA-4680 L-allo-threonine aldolase NP_825862.1 5710805 R 227882 CDS NP_825863.1 29831229 1215458 5712219..5713139 1 NC_003155.4 PF01210: NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; hypothetical protein 5713139 1215458 SAV_4686 Streptomyces avermitilis MA-4680 hypothetical protein NP_825863.1 5712219 D 227882 CDS NP_825864.1 29831230 1211045 5713136..5714137 1 NC_003155.4 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 5714137 panC 1211045 panC Streptomyces avermitilis MA-4680 pantoate--beta-alanine ligase NP_825864.1 5713136 D 227882 CDS NP_825865.1 29831231 1211046 5714134..5715951 1 NC_003155.4 catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 5715951 nadB 1211046 nadB Streptomyces avermitilis MA-4680 L-aspartate oxidase NP_825865.1 5714134 D 227882 CDS NP_825866.1 29831232 1211047 5715948..5716943 1 NC_003155.4 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase 5716943 nadC 1211047 nadC Streptomyces avermitilis MA-4680 nicotinate-nucleotide pyrophosphorylase NP_825866.1 5715948 D 227882 CDS NP_825867.1 29831233 1215459 5716953..5717750 1 NC_003155.4 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP; pantothenate kinase 5717750 1215459 SAV_4690 Streptomyces avermitilis MA-4680 pantothenate kinase NP_825867.1 5716953 D 227882 CDS NP_825868.1 29831234 1215460 5718058..5718780 1 NC_003155.4 hypothetical protein 5718780 1215460 SAV_4691 Streptomyces avermitilis MA-4680 hypothetical protein NP_825868.1 5718058 D 227882 CDS NP_825869.1 29831235 1215461 5718824..5719003 1 NC_003155.4 hypothetical protein 5719003 1215461 SAV_4692 Streptomyces avermitilis MA-4680 hypothetical protein NP_825869.1 5718824 D 227882 CDS NP_825870.1 29831236 1215462 5719170..5719703 1 NC_003155.4 hypothetical protein 5719703 1215462 SAV_4693 Streptomyces avermitilis MA-4680 hypothetical protein NP_825870.1 5719170 D 227882 CDS NP_825871.1 29831237 1215463 5719744..5720286 1 NC_003155.4 catalyzes the conversion of l-glutamate to a-N-acetyl-l-glutamate in arginine biosynthesis; N-acetylglutamate synthase 5720286 1215463 SAV_4694 Streptomyces avermitilis MA-4680 N-acetylglutamate synthase NP_825871.1 5719744 D 227882 CDS NP_825872.1 29831238 1215464 5720536..5720871 1 NC_003155.4 Lsr2-like protein 5720871 1215464 SAV_4695 Streptomyces avermitilis MA-4680 Lsr2-like protein NP_825872.1 5720536 D 227882 CDS NP_825873.1 29831239 1215465 complement(5720850..5721551) 1 NC_003155.4 proline-rich protein 5721551 1215465 SAV_4696 Streptomyces avermitilis MA-4680 proline-rich protein NP_825873.1 5720850 R 227882 CDS NP_825874.1 29831240 1211048 5721983..5724508 1 NC_003155.4 PF07724: ATPase family associated with various cellular activities (AAA); ATP-dependent Clp protease 5724508 clpC2 1211048 clpC2 Streptomyces avermitilis MA-4680 ATP-dependent Clp protease NP_825874.1 5721983 D 227882 CDS NP_825875.1 29831241 1215466 complement(5724587..5727706) 1 NC_003155.4 large ATP-binding protein 5727706 1215466 SAV_4698 Streptomyces avermitilis MA-4680 large ATP-binding protein NP_825875.1 5724587 R 227882 CDS NP_825876.1 29831242 1215467 complement(5727746..5728303) 1 NC_003155.4 hypothetical protein 5728303 1215467 SAV_4699 Streptomyces avermitilis MA-4680 hypothetical protein NP_825876.1 5727746 R 227882 CDS NP_825877.1 29831243 1215468 5728690..5729301 1 NC_003155.4 PF01551: Peptidase family M23; peptidase 5729301 1215468 SAV_4700 Streptomyces avermitilis MA-4680 peptidase NP_825877.1 5728690 D 227882 CDS NP_825878.1 29831244 1215469 complement(5729317..5729892) 1 NC_003155.4 TetR family transcriptional regulator 5729892 1215469 SAV_4701 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_825878.1 5729317 R 227882 CDS NP_825879.1 29831245 1215470 5730082..5731695 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 5731695 1215470 SAV_4702 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_825879.1 5730082 D 227882 CDS NP_825880.1 29831246 1215471 complement(5731882..5733345) 1 NC_003155.4 similar to AfsQ2; two-component system sensor kinase 5733345 1215471 SAV_4703 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_825880.1 5731882 R 227882 CDS NP_825881.1 29831247 1215472 complement(5733354..5734061) 1 NC_003155.4 similar to AfsQ1; two-component system response regulator 5734061 1215472 SAV_4704 Streptomyces avermitilis MA-4680 two-component system response regulator NP_825881.1 5733354 R 227882 CDS NP_825882.1 29831248 1215473 complement(5734105..5734695) 1 NC_003155.4 hypothetical protein 5734695 1215473 SAV_4705 Streptomyces avermitilis MA-4680 hypothetical protein NP_825882.1 5734105 R 227882 CDS NP_825883.1 29831249 1211049 complement(5734746..5735285) 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 5735285 sig41 1211049 sig41 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_825883.1 5734746 R 227882 CDS NP_825884.1 29831250 1211050 complement(5735621..5736562) 1 NC_003155.4 G/C -> T/A transversion; adenine glycosylase 5736562 mutY 1211050 mutY Streptomyces avermitilis MA-4680 adenine glycosylase NP_825884.1 5735621 R 227882 CDS NP_825885.1 29831251 1215474 5737512..5737886 1 NC_003155.4 hypothetical protein 5737886 1215474 SAV_4708 Streptomyces avermitilis MA-4680 hypothetical protein NP_825885.1 5737512 D 227882 CDS NP_825886.1 29831252 1215475 complement(5738160..5739284) 1 NC_003155.4 non-specific DNA-binding; scans chromosomes during sporulation for DNA-damage; delays initiation of sporulation; participates in a checkpoint signaling cascade for cell-cycle progression and DNA repair; DNA integrity scanning protein DisA 5739284 1215475 SAV_4709 Streptomyces avermitilis MA-4680 DNA integrity scanning protein DisA NP_825886.1 5738160 R 227882 CDS NP_825887.1 29831253 1211051 complement(5739366..5740775) 1 NC_003155.4 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 5740775 radA 1211051 radA Streptomyces avermitilis MA-4680 DNA repair protein RadA NP_825887.1 5739366 R 227882 CDS NP_825888.1 29831254 1215476 5741117..5742865 1 NC_003155.4 alanine-rich protein 5742865 1215476 SAV_4711 Streptomyces avermitilis MA-4680 alanine-rich protein NP_825888.1 5741117 D 227882 CDS NP_825889.1 29831255 1215477 complement(5742892..5743761) 1 NC_003155.4 hypothetical protein 5743761 1215477 SAV_4712 Streptomyces avermitilis MA-4680 hypothetical protein NP_825889.1 5742892 R 227882 CDS NP_825890.1 29831256 1215478 5743833..5744765 1 NC_003155.4 PF02541: Ppx/GppA phosphatase family; exopolyphosphatase 5744765 ppx2 1215478 ppx2 Streptomyces avermitilis MA-4680 exopolyphosphatase NP_825890.1 5743833 D 227882 CDS NP_825891.1 29831257 1215479 5745258..5746067 1 NC_003155.4 PF01261: AP endonuclease family 2; hypothetical protein 5746067 1215479 SAV_4714 Streptomyces avermitilis MA-4680 hypothetical protein NP_825891.1 5745258 D 227882 CDS NP_825892.1 29831258 1215480 5746064..5746681 1 NC_003155.4 TetR family transcriptional regulator 5746681 1215480 SAV_4715 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_825892.1 5746064 D 227882 CDS NP_825893.1 29831259 1211052 5746979..5748832 1 NC_003155.4 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 5748832 ilvD1 1211052 ilvD1 Streptomyces avermitilis MA-4680 dihydroxy-acid dehydratase NP_825893.1 5746979 D 227882 CDS NP_825894.1 29831260 1211053 complement(5748959..5751157) 1 NC_003155.4 AfsK homolog; serine/threonine protein kinase 5751157 pkn16 1211053 pkn16 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_825894.1 5748959 R 227882 CDS NP_825895.1 29831261 1215481 5751260..5751604 1 NC_003155.4 hypothetical protein 5751604 1215481 SAV_4718 Streptomyces avermitilis MA-4680 hypothetical protein NP_825895.1 5751260 D 227882 CDS NP_825896.1 29831262 1215482 5751675..5752259 1 NC_003155.4 hypothetical protein 5752259 1215482 SAV_4719 Streptomyces avermitilis MA-4680 hypothetical protein NP_825896.1 5751675 D 227882 CDS NP_825897.1 29831263 1215483 5752401..5753033 1 NC_003155.4 hypothetical protein 5753033 1215483 SAV_4720 Streptomyces avermitilis MA-4680 hypothetical protein NP_825897.1 5752401 D 227882 CDS NP_825898.1 29831264 1215484 complement(5753085..5754560) 1 NC_003155.4 PF00916: Sulfate transporter family; sulfate transporter 5754560 1215484 SAV_4721 Streptomyces avermitilis MA-4680 sulfate transporter NP_825898.1 5753085 R 227882 CDS NP_825899.1 29831265 1215485 5754929..5755756 1 NC_003155.4 ABC transporter ATP-binding protein 5755756 1215485 SAV_4722 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_825899.1 5754929 D 227882 CDS NP_825900.1 29831266 1215486 5755753..5756544 1 NC_003155.4 ABC transporter permease 5756544 1215486 SAV_4723 Streptomyces avermitilis MA-4680 ABC transporter permease NP_825900.1 5755753 D 227882 CDS NP_825901.1 29831267 1211054 5756668..5757477 1 NC_003155.4 pyrroline-5-carboxylate reductase 5757477 proC 1211054 proC Streptomyces avermitilis MA-4680 pyrroline-5-carboxylate reductase NP_825901.1 5756668 D 227882 CDS NP_825902.1 29831268 1211055 complement(5757496..5758491) 1 NC_003155.4 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 5758491 trpS2 1211055 trpS2 Streptomyces avermitilis MA-4680 tryptophanyl-tRNA synthetase NP_825902.1 5757496 R 227882 CDS NP_825903.1 29831269 1215487 5764588..5765232 1 NC_003155.4 PF00702: haloacid dehalogenase-like hydrolase; hydrolase 5765232 1215487 SAV_4726 Streptomyces avermitilis MA-4680 hydrolase NP_825903.1 5764588 D 227882 CDS NP_825904.1 29831270 1215488 5765381..5766082 1 NC_003155.4 hypothetical protein 5766082 1215488 SAV_4727 Streptomyces avermitilis MA-4680 hypothetical protein NP_825904.1 5765381 D 227882 CDS NP_825905.1 29831271 1215489 5766176..5767387 1 NC_003155.4 PF07690: Major Facilitator Superfamily; integral membrane transport protein 5767387 1215489 SAV_4728 Streptomyces avermitilis MA-4680 integral membrane transport protein NP_825905.1 5766176 D 227882 CDS NP_825906.1 29831272 1211059 5767407..5768510 1 NC_003155.4 acetoin dehydrogenase 5768510 acuC 1211059 acuC Streptomyces avermitilis MA-4680 acetoin dehydrogenase NP_825906.1 5767407 D 227882 CDS NP_825907.1 29831273 1215490 5768693..5769508 1 NC_003155.4 hypothetical protein 5769508 1215490 SAV_4730 Streptomyces avermitilis MA-4680 hypothetical protein NP_825907.1 5768693 D 227882 CDS NP_825908.1 29831274 1215491 5769605..5769850 1 NC_003155.4 hypothetical protein 5769850 1215491 SAV_4731 Streptomyces avermitilis MA-4680 hypothetical protein NP_825908.1 5769605 D 227882 CDS NP_825909.1 29831275 1215492 5770447..5771496 1 NC_003155.4 NAD-dependent epimerase/dehydratase 5771496 1215492 SAV_4732 Streptomyces avermitilis MA-4680 NAD-dependent epimerase/dehydratase NP_825909.1 5770447 D 227882 CDS NP_825910.1 29831276 1215493 5771511..5772557 1 NC_003155.4 acyltransferase 5772557 1215493 SAV_4733 Streptomyces avermitilis MA-4680 acyltransferase NP_825910.1 5771511 D 227882 CDS NP_825911.1 29831277 1215494 complement(5772617..5773852) 1 NC_003155.4 hypothetical protein 5773852 1215494 SAV_4734 Streptomyces avermitilis MA-4680 hypothetical protein NP_825911.1 5772617 R 227882 CDS NP_825912.1 29831278 1211060 complement(5774150..5774926) 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 5774926 sig42 1211060 sig42 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_825912.1 5774150 R 227882 CDS NP_825913.1 29831279 1211061 complement(5775345..5776235) 1 NC_003155.4 3-phosphoserine phosphatase 5776235 serB1 1211061 serB1 Streptomyces avermitilis MA-4680 3-phosphoserine phosphatase NP_825913.1 5775345 R 227882 CDS NP_825914.1 29831280 1215495 5776429..5776737 1 NC_003155.4 redoxin 5776737 1215495 SAV_4737 Streptomyces avermitilis MA-4680 redoxin NP_825914.1 5776429 D 227882 CDS NP_825915.1 29831281 1215496 5777053..5777811 1 NC_003155.4 modulates transcription in response to the NADH/NAD(+) redox state; redox-sensing transcriptional repressor Rex 5777811 1215496 SAV_4738 Streptomyces avermitilis MA-4680 redox-sensing transcriptional repressor Rex NP_825915.1 5777053 D 227882 CDS NP_825916.1 29831282 1211062 5777808..5779517 1 NC_003155.4 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 5779517 hemA 1211062 hemA Streptomyces avermitilis MA-4680 glutamyl-tRNA reductase NP_825916.1 5777808 D 227882 CDS NP_825917.1 29831283 1211063 5779514..5780488 1 NC_003155.4 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 5780488 hemC 1211063 hemC Streptomyces avermitilis MA-4680 porphobilinogen deaminase NP_825917.1 5779514 D 227882 CDS NP_825918.1 29831284 1211064 5780485..5782200 1 NC_003155.4 uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase 5782200 hemD 1211064 hemD Streptomyces avermitilis MA-4680 uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase NP_825918.1 5780485 D 227882 CDS NP_825919.1 29831285 1211065 5782340..5783332 1 NC_003155.4 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 5783332 hemB 1211065 hemB Streptomyces avermitilis MA-4680 delta-aminolevulinic acid dehydratase NP_825919.1 5782340 D 227882 CDS NP_825920.1 29831286 1215497 complement(5783378..5784094) 1 NC_003155.4 hypothetical protein 5784094 1215497 SAV_4743 Streptomyces avermitilis MA-4680 hypothetical protein NP_825920.1 5783378 R 227882 CDS NP_825921.1 29831287 1215498 5784150..5785505 1 NC_003155.4 DNA-binding protein 5785505 1215498 SAV_4744 Streptomyces avermitilis MA-4680 DNA-binding protein NP_825921.1 5784150 D 227882 CDS NP_825922.1 29831288 1215499 5785614..5786516 1 NC_003155.4 PF04672: Protein of unknown function (DUF574); hypothetical protein 5786516 1215499 SAV_4745 Streptomyces avermitilis MA-4680 hypothetical protein NP_825922.1 5785614 D 227882 CDS NP_825923.1 29831289 1215500 complement(5786563..5787516) 1 NC_003155.4 phosphotransferase 5787516 1215500 SAV_4746 Streptomyces avermitilis MA-4680 phosphotransferase NP_825923.1 5786563 R 227882 CDS NP_825924.1 29831290 1215501 complement(5787654..5788565) 1 NC_003155.4 hypothetical protein 5788565 1215501 SAV_4747 Streptomyces avermitilis MA-4680 hypothetical protein NP_825924.1 5787654 R 227882 CDS NP_825925.1 29831291 1211066 complement(5788728..5790500) 1 NC_003155.4 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 5790500 argS 1211066 argS Streptomyces avermitilis MA-4680 arginyl-tRNA synthetase NP_825925.1 5788728 R 227882 CDS NP_825926.1 29831292 1211067 5790745..5792391 1 NC_003155.4 class I; LysRS1; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri this enzyme charges both tRNA molecules for lysine that exist in this organism (but the tRNALysUUU very poorly) and in the presence of LysRS2 can charge tRNAPyl with lysine; lysyl-tRNA synthetase 5792391 lysK 1211067 lysK Streptomyces avermitilis MA-4680 lysyl-tRNA synthetase NP_825926.1 5790745 D 227882 CDS NP_825927.1 29831293 1215502 complement(5792501..5793820) 1 NC_003155.4 hypothetical protein 5793820 1215502 SAV_4750 Streptomyces avermitilis MA-4680 hypothetical protein NP_825927.1 5792501 R 227882 CDS NP_825928.1 29831294 1215503 complement(5793986..5794936) 1 NC_003155.4 hypothetical protein 5794936 1215503 SAV_4751 Streptomyces avermitilis MA-4680 hypothetical protein NP_825928.1 5793986 R 227882 CDS NP_825929.1 29831295 1215504 complement(5795091..5795966) 1 NC_003155.4 hypothetical protein 5795966 1215504 SAV_4752 Streptomyces avermitilis MA-4680 hypothetical protein NP_825929.1 5795091 R 227882 CDS NP_825930.1 29831296 1215505 5796203..5797396 1 NC_003155.4 PF01139: Uncharacterized protein family UPF0027; hypothetical protein 5797396 1215505 SAV_4753 Streptomyces avermitilis MA-4680 hypothetical protein NP_825930.1 5796203 D 227882 CDS NP_825931.1 29831297 1215506 complement(5797440..5797877) 1 NC_003155.4 hypothetical protein 5797877 1215506 SAV_4754 Streptomyces avermitilis MA-4680 hypothetical protein NP_825931.1 5797440 R 227882 CDS NP_825932.1 29831298 1215507 complement(5798544..5799323) 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 5799323 1215507 SAV_4755 Streptomyces avermitilis MA-4680 dehydrogenase NP_825932.1 5798544 R 227882 CDS NP_825933.1 29831299 1215508 complement(5799434..5799772) 1 NC_003155.4 hypothetical protein 5799772 1215508 SAV_4756 Streptomyces avermitilis MA-4680 hypothetical protein NP_825933.1 5799434 R 227882 CDS NP_825934.1 29831300 1215509 5799890..5800381 1 NC_003155.4 MarR family transcriptional regulator 5800381 1215509 SAV_4757 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_825934.1 5799890 D 227882 CDS NP_825935.1 29831301 1215510 complement(5800409..5800819) 1 NC_003155.4 PF01638: Transcriptional regulator; transcriptional regulator 5800819 1215510 SAV_4758 Streptomyces avermitilis MA-4680 transcriptional regulator NP_825935.1 5800409 R 227882 CDS NP_825936.1 29831302 1215511 5800956..5801834 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 5801834 1215511 SAV_4759 Streptomyces avermitilis MA-4680 dehydrogenase NP_825936.1 5800956 D 227882 CDS NP_825937.1 29831303 1215512 complement(5801897..5803312) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 5803312 1215512 SAV_4760 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_825937.1 5801897 R 227882 CDS NP_825938.1 29831304 1215513 5803321..5803845 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; hypothetical protein 5803845 1215513 SAV_4761 Streptomyces avermitilis MA-4680 hypothetical protein NP_825938.1 5803321 D 227882 CDS NP_825939.1 29831305 1215514 complement(5803942..5804751) 1 NC_003155.4 AraC family transcription regulator 5804751 1215514 SAV_4762 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_825939.1 5803942 R 227882 CDS NP_825940.1 29831306 1215515 5804947..5806041 1 NC_003155.4 PF00296: Luciferase-like monooxygenase; monooxygenase 5806041 1215515 SAV_4763 Streptomyces avermitilis MA-4680 monooxygenase NP_825940.1 5804947 D 227882 CDS NP_825941.1 29831307 1215516 5806041..5806769 1 NC_003155.4 NAD(P)H-dependent FMN reductase 5806769 1215516 SAV_4764 Streptomyces avermitilis MA-4680 NAD(P)H-dependent FMN reductase NP_825941.1 5806041 D 227882 CDS NP_825942.1 29831308 1215517 complement(5806803..5808941) 1 NC_003155.4 PF03929: PepSY-associated TM helix; hypothetical protein 5808941 1215517 SAV_4765 Streptomyces avermitilis MA-4680 hypothetical protein NP_825942.1 5806803 R 227882 CDS NP_825943.1 29831309 1215518 complement(5808938..5810263) 1 NC_003155.4 PF00534: Glycosyl transferases group 1; glycosyl transferase 5810263 1215518 SAV_4766 Streptomyces avermitilis MA-4680 glycosyl transferase NP_825943.1 5808938 R 227882 CDS NP_825944.1 29831310 1215519 5810406..5811143 1 NC_003155.4 two-component system response regulator 5811143 1215519 SAV_4767 Streptomyces avermitilis MA-4680 two-component system response regulator NP_825944.1 5810406 D 227882 CDS NP_825945.1 29831311 1215520 5811144..5812799 1 NC_003155.4 two-component system sensor kinase 5812799 1215520 SAV_4768 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_825945.1 5811144 D 227882 CDS NP_825946.1 29831312 1215521 complement(5812840..5814837) 1 NC_003155.4 PF03023: MviN-like protein; amino acid transporter 5814837 1215521 SAV_4769 Streptomyces avermitilis MA-4680 amino acid transporter NP_825946.1 5812840 R 227882 CDS NP_825947.1 29831313 1215522 5815106..5815591 1 NC_003155.4 hypothetical protein 5815591 1215522 SAV_4770 Streptomyces avermitilis MA-4680 hypothetical protein NP_825947.1 5815106 D 227882 CDS NP_825948.1 29831314 1215523 5815897..5816517 1 NC_003155.4 hypothetical protein 5816517 1215523 SAV_4771 Streptomyces avermitilis MA-4680 hypothetical protein NP_825948.1 5815897 D 227882 CDS NP_825949.1 29831315 1215524 complement(5816453..5817148) 1 NC_003155.4 DJ-1/PfpI family transcriptional regulator 5817148 1215524 SAV_4772 Streptomyces avermitilis MA-4680 DJ-1/PfpI family transcriptional regulator NP_825949.1 5816453 R 227882 CDS NP_825950.1 29831316 1215525 5817276..5818232 1 NC_003155.4 LysR family transcriptional regulator 5818232 abaB2 1215525 abaB2 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_825950.1 5817276 D 227882 CDS NP_825951.1 29831317 1215526 complement(5818290..5820326) 1 NC_003155.4 amino acid permease 5820326 1215526 SAV_4774 Streptomyces avermitilis MA-4680 amino acid permease NP_825951.1 5818290 R 227882 CDS NP_825952.1 29831318 1215527 complement(5820572..5821132) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; hypothetical protein 5821132 1215527 SAV_4775 Streptomyces avermitilis MA-4680 hypothetical protein NP_825952.1 5820572 R 227882 CDS NP_825953.1 29831319 1211068 5821553..5821756 1 NC_003155.4 cold shock protein 5821756 cspD5 1211068 cspD5 Streptomyces avermitilis MA-4680 cold shock protein NP_825953.1 5821553 D 227882 CDS NP_825954.1 29831320 1215528 complement(5822204..5822881) 1 NC_003155.4 PF03713: Domain of unknown function (DUF305); hypothetical protein 5822881 1215528 SAV_4777 Streptomyces avermitilis MA-4680 hypothetical protein NP_825954.1 5822204 R 227882 CDS NP_825955.1 29831321 1215529 complement(5822982..5823455) 1 NC_003155.4 hypothetical protein 5823455 1215529 SAV_4778 Streptomyces avermitilis MA-4680 hypothetical protein NP_825955.1 5822982 R 227882 CDS NP_825956.1 29831322 1215530 complement(5823653..5824519) 1 NC_003155.4 catalyzes the cleavage of carbon-halogen bonds in aliphatic compounds forming a primary alcohol and a halide; haloalkane dehalogenase 5824519 1215530 SAV_4779 Streptomyces avermitilis MA-4680 haloalkane dehalogenase NP_825956.1 5823653 R 227882 CDS NP_825957.1 29831323 1215531 complement(5824531..5824983) 1 NC_003155.4 PF01243: Pyridoxamine 5'-phosphate oxidase; hypothetical protein 5824983 1215531 SAV_4780 Streptomyces avermitilis MA-4680 hypothetical protein NP_825957.1 5824531 R 227882 CDS NP_825958.1 29831324 1215532 complement(5825037..5825858) 1 NC_003155.4 hypothetical protein 5825858 1215532 SAV_4781 Streptomyces avermitilis MA-4680 hypothetical protein NP_825958.1 5825037 R 227882 CDS NP_825959.1 29831325 1215533 5825957..5826550 1 NC_003155.4 TetR family transcriptional regulator 5826550 1215533 SAV_4782 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_825959.1 5825957 D 227882 CDS NP_825960.1 29831326 1215534 5826781..5827365 1 NC_003155.4 regulatory protein 5827365 1215534 SAV_4783 Streptomyces avermitilis MA-4680 regulatory protein NP_825960.1 5826781 D 227882 CDS NP_825961.1 29831327 1215535 5827528..5828130 1 NC_003155.4 hypothetical protein 5828130 1215535 SAV_4784 Streptomyces avermitilis MA-4680 hypothetical protein NP_825961.1 5827528 D 227882 CDS NP_825962.1 29831328 1215536 5828137..5828376 1 NC_003155.4 hypothetical protein 5828376 1215536 SAV_4785 Streptomyces avermitilis MA-4680 hypothetical protein NP_825962.1 5828137 D 227882 CDS NP_825963.1 29831329 1215537 5828339..5828806 1 NC_003155.4 hypothetical protein 5828806 1215537 SAV_4786 Streptomyces avermitilis MA-4680 hypothetical protein NP_825963.1 5828339 D 227882 CDS NP_825964.1 29831330 1215538 5829173..5829550 1 NC_003155.4 PF01740: STAS domain; anti-sigma factor antagonist 5829550 1215538 SAV_4787 Streptomyces avermitilis MA-4680 anti-sigma factor antagonist NP_825964.1 5829173 D 227882 CDS NP_825965.1 29831331 1215539 5829547..5830257 1 NC_003155.4 hypothetical protein 5830257 1215539 SAV_4788 Streptomyces avermitilis MA-4680 hypothetical protein NP_825965.1 5829547 D 227882 CDS NP_825966.1 29831332 1215540 complement(5830360..5831214) 1 NC_003155.4 PF04672: Protein of unknown function (DUF574); hypothetical protein 5831214 1215540 SAV_4789 Streptomyces avermitilis MA-4680 hypothetical protein NP_825966.1 5830360 R 227882 CDS NP_825967.1 29831333 1215541 complement(5831272..5832210) 1 NC_003155.4 LysR family transcriptional regulator 5832210 1215541 SAV_4790 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_825967.1 5831272 R 227882 CDS NP_825968.1 29831334 1215542 5832251..5833252 1 NC_003155.4 PF00892: Integral membrane protein DUF6; hypothetical protein 5833252 1215542 SAV_4791 Streptomyces avermitilis MA-4680 hypothetical protein NP_825968.1 5832251 D 227882 CDS NP_825969.1 29831335 1215543 5833276..5833944 1 NC_003155.4 PF01118: Semialdehyde dehydrogenase, NAD binding domain; hypothetical protein 5833944 1215543 SAV_4792 Streptomyces avermitilis MA-4680 hypothetical protein NP_825969.1 5833276 D 227882 CDS NP_825970.1 29831336 1215544 complement(5834013..5834450) 1 NC_003155.4 hypothetical protein 5834450 1215544 SAV_4793 Streptomyces avermitilis MA-4680 hypothetical protein NP_825970.1 5834013 R 227882 CDS NP_825971.1 29831337 1215545 5834609..5835223 1 NC_003155.4 hypothetical protein 5835223 1215545 SAV_4794 Streptomyces avermitilis MA-4680 hypothetical protein NP_825971.1 5834609 D 227882 CDS NP_825972.1 29831338 1211069 5835211..5836527 1 NC_003155.4 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 5836527 hemL 1211069 hemL Streptomyces avermitilis MA-4680 glutamate-1-semialdehyde aminotransferase NP_825972.1 5835211 D 227882 CDS NP_825973.1 29831339 1215546 5836524..5837216 1 NC_003155.4 phosphoglycerate mutase 5837216 1215546 SAV_4796 Streptomyces avermitilis MA-4680 phosphoglycerate mutase NP_825973.1 5836524 D 227882 CDS NP_825974.1 29831340 1215547 5837392..5838669 1 NC_003155.4 PF01522: Polysaccharide deacetylase; hypothetical protein 5838669 1215547 SAV_4797 Streptomyces avermitilis MA-4680 hypothetical protein NP_825974.1 5837392 D 227882 CDS NP_825975.1 29831341 1215548 5838736..5839368 1 NC_003155.4 PF00578: AhpC/TSA family; hypothetical protein 5839368 1215548 SAV_4798 Streptomyces avermitilis MA-4680 hypothetical protein NP_825975.1 5838736 D 227882 CDS NP_825976.1 29831342 1211070 5839375..5840157 1 NC_003155.4 cytochrome C biogenesis membrane protein 5840157 ccsA 1211070 ccsA Streptomyces avermitilis MA-4680 cytochrome C biogenesis membrane protein NP_825976.1 5839375 D 227882 CDS NP_825977.1 29831343 1211071 5840161..5841948 1 NC_003155.4 cytochrome C biogenesis membrane protein 5841948 ccs-1 1211071 ccs-1 Streptomyces avermitilis MA-4680 cytochrome C biogenesis membrane protein NP_825977.1 5840161 D 227882 CDS NP_825978.1 29831344 1211072 5841945..5843021 1 NC_003155.4 cytochrome C assembly protein 5843021 ccsB 1211072 ccsB Streptomyces avermitilis MA-4680 cytochrome C assembly protein NP_825978.1 5841945 D 227882 CDS NP_825979.1 29831345 1215549 5843152..5843637 1 NC_003155.4 hypothetical protein 5843637 1215549 SAV_4802 Streptomyces avermitilis MA-4680 hypothetical protein NP_825979.1 5843152 D 227882 CDS NP_825980.1 29831346 1215550 complement(5843661..5845208) 1 NC_003155.4 PF01094: Receptor family ligand binding region; hypothetical protein 5845208 1215550 SAV_4803 Streptomyces avermitilis MA-4680 hypothetical protein NP_825980.1 5843661 R 227882 CDS NP_825981.1 29831347 1215551 complement(5845208..5847307) 1 NC_003155.4 hypothetical protein 5847307 1215551 SAV_4804 Streptomyces avermitilis MA-4680 hypothetical protein NP_825981.1 5845208 R 227882 CDS NP_825982.1 29831348 1215552 complement(5847436..5848410) 1 NC_003155.4 PF03171: 2OG-Fe(II) oxygenase superfamily; oxidoreductase 5848410 1215552 SAV_4805 Streptomyces avermitilis MA-4680 oxidoreductase NP_825982.1 5847436 R 227882 CDS NP_825983.1 29831349 1211073 complement(5848403..5848864) 1 NC_003155.4 PF00383: Cytidine and deoxycytidylate deaminase zinc-binding region; cytidine/deoxycytidine deaminase 5848864 cdd4 1211073 cdd4 Streptomyces avermitilis MA-4680 cytidine/deoxycytidine deaminase NP_825983.1 5848403 R 227882 CDS NP_825984.1 29831350 1215553 complement(5849102..5849545) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 5849545 1215553 SAV_4807 Streptomyces avermitilis MA-4680 acetyltransferase NP_825984.1 5849102 R 227882 CDS NP_825985.1 29831351 1215554 complement(5849693..5850085) 1 NC_003155.4 hypothetical protein 5850085 1215554 SAV_4808 Streptomyces avermitilis MA-4680 hypothetical protein NP_825985.1 5849693 R 227882 CDS NP_825986.1 29831352 1211074 5850173..5851624 1 NC_003155.4 PF01977: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; decarboxylase 5851624 ubiX 1211074 ubiX Streptomyces avermitilis MA-4680 decarboxylase NP_825986.1 5850173 D 227882 CDS NP_825987.1 29831353 1211075 5851621..5852526 1 NC_003155.4 UbiA prenyltransferase family catalyzes the transfer of a prenyl group to various acceptors with hydrophobic ring structures in the biosynthesis of respiratory quinones, hemes, chlorophylls, vitamin E, and shikonin; prenyltransferase 5852526 ubiA 1211075 ubiA Streptomyces avermitilis MA-4680 prenyltransferase NP_825987.1 5851621 D 227882 CDS NP_825988.1 29831354 1211076 5852782..5853447 1 NC_003155.4 PF02441: Flavoprotein; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 5853447 ubiD 1211076 ubiD Streptomyces avermitilis MA-4680 3-octaprenyl-4-hydroxybenzoate carboxy-lyase NP_825988.1 5852782 D 227882 CDS NP_825989.1 29831355 1215555 5853523..5853978 1 NC_003155.4 transcription regulator AsnC 5853978 1215555 SAV_4812 Streptomyces avermitilis MA-4680 transcription regulator AsnC NP_825989.1 5853523 D 227882 CDS NP_825990.1 29831356 1215556 5854065..5855228 1 NC_003155.4 PF04055: Radical SAM superfamily; hypothetical protein 5855228 1215556 SAV_4813 Streptomyces avermitilis MA-4680 hypothetical protein NP_825990.1 5854065 D 227882 CDS NP_825991.1 29831357 1215557 5855236..5855772 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 5855772 1215557 SAV_4814 Streptomyces avermitilis MA-4680 acetyltransferase NP_825991.1 5855236 D 227882 CDS NP_825992.1 29831358 1215558 5855867..5856166 1 NC_003155.4 hypothetical protein 5856166 1215558 SAV_4815 Streptomyces avermitilis MA-4680 hypothetical protein NP_825992.1 5855867 D 227882 CDS NP_825993.1 29831359 1215559 5856259..5856900 1 NC_003155.4 TetR family transcriptional regulator 5856900 1215559 SAV_4816 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_825993.1 5856259 D 227882 CDS NP_825994.1 29831360 1215560 complement(5856928..5857854) 1 NC_003155.4 PF01575: MaoC like domain; dehydratase 5857854 1215560 SAV_4817 Streptomyces avermitilis MA-4680 dehydratase NP_825994.1 5856928 R 227882 CDS NP_825995.1 29831361 1211077 5858175..5860091 1 NC_003155.4 PF00501: AMP-binding enzyme; acyl-CoA synthetase, long-chain fatty acid:CoA ligase 5860091 fadD10 1211077 fadD10 Streptomyces avermitilis MA-4680 acyl-CoA synthetase, long-chain fatty acid:CoA ligase NP_825995.1 5858175 D 227882 CDS NP_825996.1 29831362 1215561 5860168..5860665 1 NC_003155.4 hypothetical protein 5860665 1215561 SAV_4819 Streptomyces avermitilis MA-4680 hypothetical protein NP_825996.1 5860168 D 227882 CDS NP_825997.1 29831363 1211078 complement(5860779..5860982) 1 NC_003155.4 cold shock protein 5860982 cspD6 1211078 cspD6 Streptomyces avermitilis MA-4680 cold shock protein NP_825997.1 5860779 R 227882 CDS NP_825998.1 29831364 1215562 5861326..5862174 1 NC_003155.4 PF02621: Uncharacterized ACR, COG1427; hypothetical protein 5862174 1215562 SAV_4821 Streptomyces avermitilis MA-4680 hypothetical protein NP_825998.1 5861326 D 227882 CDS NP_825999.1 29831365 1211079 5862253..5864004 1 NC_003155.4 serine/threonine protein kinase 5864004 pkn17 1211079 pkn17 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_825999.1 5862253 D 227882 CDS NP_826000.1 29831366 1215563 complement(5863997..5864677) 1 NC_003155.4 hypothetical protein 5864677 1215563 SAV_4823 Streptomyces avermitilis MA-4680 hypothetical protein NP_826000.1 5863997 R 227882 CDS NP_826001.1 29831367 1215564 5864704..5865447 1 NC_003155.4 PF01478: Type IV leader peptidase family; type IV peptidase 5865447 1215564 SAV_4824 Streptomyces avermitilis MA-4680 type IV peptidase NP_826001.1 5864704 D 227882 CDS NP_826002.1 29831368 1215565 5865567..5866766 1 NC_003155.4 PF04055: radical SAM superfamily domain; hypothetical protein 5866766 1215565 SAV_4825 Streptomyces avermitilis MA-4680 hypothetical protein NP_826002.1 5865567 D 227882 CDS NP_826003.1 29831369 1215566 5866774..5867223 1 NC_003155.4 hypothetical protein 5867223 1215566 SAV_4826 Streptomyces avermitilis MA-4680 hypothetical protein NP_826003.1 5866774 D 227882 CDS NP_826004.1 29831370 1215567 complement(5867255..5868304) 1 NC_003155.4 PF00704: Glycosyl hydrolases family 18; sugar hydrolase 5868304 1215567 SAV_4827 Streptomyces avermitilis MA-4680 sugar hydrolase NP_826004.1 5867255 R 227882 CDS NP_826005.1 29831371 1215568 5868612..5869004 1 NC_003155.4 hypothetical protein 5869004 1215568 SAV_4828 Streptomyces avermitilis MA-4680 hypothetical protein NP_826005.1 5868612 D 227882 CDS NP_826006.1 29831372 1215569 5869025..5871397 1 NC_003155.4 PF01522: Polysaccharide deacetylase; polysaccharide deacetylase/glycosyl transferase 5871397 1215569 SAV_4829 Streptomyces avermitilis MA-4680 polysaccharide deacetylase/glycosyl transferase NP_826006.1 5869025 D 227882 CDS NP_826007.1 29831373 1215570 5871397..5872812 1 NC_003155.4 PF01757: Acyltransferase family; hypothetical protein 5872812 1215570 SAV_4830 Streptomyces avermitilis MA-4680 hypothetical protein NP_826007.1 5871397 D 227882 CDS NP_826008.1 29831374 1211080 5872885..5873580 1 NC_003155.4 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 5873580 ubiE 1211080 ubiE Streptomyces avermitilis MA-4680 ubiquinone/menaquinone biosynthesis methyltransferase NP_826008.1 5872885 D 227882 CDS NP_826009.1 29831375 1215571 5873712..5876213 1 NC_003155.4 PF03884: Domain of unknown function (DUF329); hypothetical protein 5876213 1215571 SAV_4832 Streptomyces avermitilis MA-4680 hypothetical protein NP_826009.1 5873712 D 227882 CDS NP_826010.1 29831376 1215572 complement(5876206..5876553) 1 NC_003155.4 PF03793: PASTA domain; hypothetical protein 5876553 1215572 SAV_4833 Streptomyces avermitilis MA-4680 hypothetical protein NP_826010.1 5876206 R 227882 CDS NP_826011.1 29831377 1215573 complement(5876638..5877144) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 5877144 1215573 SAV_4834 Streptomyces avermitilis MA-4680 acetyltransferase NP_826011.1 5876638 R 227882 CDS NP_826012.1 29831378 1215574 5877245..5878549 1 NC_003155.4 PF01494: FAD binding domain; electron transfer oxidoreductase 5878549 1215574 SAV_4835 Streptomyces avermitilis MA-4680 electron transfer oxidoreductase NP_826012.1 5877245 D 227882 CDS NP_826013.1 29831379 1215575 complement(5878799..5879617) 1 NC_003155.4 Seems to have no N-terminal signal sequence; NLP/P60-family protein 5879617 1215575 SAV_4836 Streptomyces avermitilis MA-4680 NLP/P60-family protein NP_826013.1 5878799 R 227882 CDS NP_826014.1 29831380 1211081 5880403..5880762 1 NC_003155.4 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A 5880762 nuoA1 1211081 nuoA1 Streptomyces avermitilis MA-4680 NADH dehydrogenase subunit A NP_826014.1 5880403 D 227882 CDS NP_826015.1 29831381 1211082 5880778..5881332 1 NC_003155.4 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 5881332 nuoB1 1211082 nuoB1 Streptomyces avermitilis MA-4680 NADH dehydrogenase subunit B NP_826015.1 5880778 D 227882 CDS NP_826016.1 29831382 1211083 5881329..5882075 1 NC_003155.4 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit C 5882075 nuoC 1211083 nuoC Streptomyces avermitilis MA-4680 NADH dehydrogenase subunit C NP_826016.1 5881329 D 227882 CDS NP_826017.1 29831383 1211084 5882072..5883403 1 NC_003155.4 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit D 5883403 nuoD1 1211084 nuoD1 Streptomyces avermitilis MA-4680 NADH dehydrogenase subunit D NP_826017.1 5882072 D 227882 CDS NP_826018.1 29831384 1211085 5883400..5884263 1 NC_003155.4 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 5884263 nuoE 1211085 nuoE Streptomyces avermitilis MA-4680 NADH dehydrogenase subunit E NP_826018.1 5883400 D 227882 CDS NP_826019.1 29831385 1211086 5884260..5885609 1 NC_003155.4 NADH dehydrogenase I chain F 5885609 nuoF1 1211086 nuoF1 Streptomyces avermitilis MA-4680 NADH dehydrogenase I chain F NP_826019.1 5884260 D 227882 CDS NP_826020.1 29831386 1211087 5885606..5888110 1 NC_003155.4 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G 5888110 nuoG1 1211087 nuoG1 Streptomyces avermitilis MA-4680 NADH dehydrogenase subunit G NP_826020.1 5885606 D 227882 CDS NP_826021.1 29831387 1211088 5888107..5889471 1 NC_003155.4 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 5889471 nuoH1 1211088 nuoH1 Streptomyces avermitilis MA-4680 NADH dehydrogenase subunit H NP_826021.1 5888107 D 227882 CDS NP_826022.1 29831388 1211089 5889464..5890066 1 NC_003155.4 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 5890066 nuoI1 1211089 nuoI1 Streptomyces avermitilis MA-4680 NADH dehydrogenase subunit I NP_826022.1 5889464 D 227882 CDS NP_826023.1 29831389 1211090 5890063..5890905 1 NC_003155.4 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 5890905 nuoJ1 1211090 nuoJ1 Streptomyces avermitilis MA-4680 NADH dehydrogenase subunit J NP_826023.1 5890063 D 227882 CDS NP_826024.1 29831390 1211091 5890902..5891201 1 NC_003155.4 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 5891201 nuoK1 1211091 nuoK1 Streptomyces avermitilis MA-4680 NADH dehydrogenase subunit K NP_826024.1 5890902 D 227882 CDS NP_826025.1 29831391 1211092 5891215..5893119 1 NC_003155.4 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 5893119 nuoL1 1211092 nuoL1 Streptomyces avermitilis MA-4680 NADH dehydrogenase subunit L NP_826025.1 5891215 D 227882 CDS NP_826026.1 29831392 1211093 5893125..5894723 1 NC_003155.4 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 5894723 nuoM1 1211093 nuoM1 Streptomyces avermitilis MA-4680 NADH dehydrogenase subunit M NP_826026.1 5893125 D 227882 CDS NP_826027.1 29831393 1211094 5894720..5896348 1 NC_003155.4 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 5896348 nuoN1 1211094 nuoN1 Streptomyces avermitilis MA-4680 NADH dehydrogenase subunit N NP_826027.1 5894720 D 227882 CDS NP_826028.1 29831394 1211095 5896755..5898731 1 NC_003155.4 PF00270: DEAD/DEAH box helicase; ATP-dependent DNA helicase 5898731 recQ 1211095 recQ Streptomyces avermitilis MA-4680 ATP-dependent DNA helicase NP_826028.1 5896755 D 227882 CDS NP_826029.1 29831395 1215576 complement(5898810..5901629) 1 NC_003155.4 PF00890: FAD binding domain; putative oxidoreductase/HEAT repeat-containing protein 5901629 1215576 SAV_4852 Streptomyces avermitilis MA-4680 putative oxidoreductase/HEAT repeat-containing protein NP_826029.1 5898810 R 227882 CDS NP_826030.1 29831396 1215577 complement(5901695..5902507) 1 NC_003155.4 ABC transporter ATP-binding protein 5902507 1215577 SAV_4853 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_826030.1 5901695 R 227882 CDS NP_826031.1 29831397 1215578 complement(5902488..5903357) 1 NC_003155.4 ABC transporter permease 5903357 1215578 SAV_4854 Streptomyces avermitilis MA-4680 ABC transporter permease NP_826031.1 5902488 R 227882 CDS NP_826032.1 29831398 1215579 complement(5903354..5904700) 1 NC_003155.4 ABC transporter substrate-binding protein 5904700 1215579 SAV_4855 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_826032.1 5903354 R 227882 CDS NP_826033.1 29831399 1211096 complement(5904716..5904943) 1 NC_003155.4 ferredoxin 5904943 fdxE 1211096 fdxE Streptomyces avermitilis MA-4680 ferredoxin NP_826033.1 5904716 R 227882 CDS NP_826034.1 29831400 1215580 complement(5905018..5905797) 1 NC_003155.4 PF07702: UbiC transcription regulator-associated; GntR family transcriptional regulator 5905797 1215580 SAV_4857 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_826034.1 5905018 R 227882 CDS NP_826035.1 29831401 1211097 complement(5906169..5907392) 1 NC_003155.4 fumarylacetoacetase 5907392 fahA 1211097 fahA Streptomyces avermitilis MA-4680 fumarylacetoacetase NP_826035.1 5906169 R 227882 CDS NP_826036.1 29831402 1215581 5907567..5908856 1 NC_003155.4 hypothetical protein 5908856 1215581 SAV_4859 Streptomyces avermitilis MA-4680 hypothetical protein NP_826036.1 5907567 D 227882 CDS NP_826037.1 29831403 1215582 5908906..5910108 1 NC_003155.4 PF00070: Pyridine nucleotide-disulphide oxidoreductase; oxidoreductase 5910108 1215582 SAV_4860 Streptomyces avermitilis MA-4680 oxidoreductase NP_826037.1 5908906 D 227882 CDS NP_826038.1 29831404 1215583 5910408..5911220 1 NC_003155.4 PF00702: haloacid dehalogenase-like hydrolase; hydrolase 5911220 1215583 SAV_4861 Streptomyces avermitilis MA-4680 hydrolase NP_826038.1 5910408 D 227882 CDS NP_826039.1 29831405 1215584 complement(5911238..5911714) 1 NC_003155.4 PF01464: Transglycosylase SLT domain; hypothetical protein 5911714 1215584 SAV_4862 Streptomyces avermitilis MA-4680 hypothetical protein NP_826039.1 5911238 R 227882 CDS NP_826040.1 29831406 1215585 complement(5912224..5914278) 1 NC_003155.4 PF02129: Pro dipeptidyl-peptidase (S15 family); hypothetical protein 5914278 1215585 SAV_4863 Streptomyces avermitilis MA-4680 hypothetical protein NP_826040.1 5912224 R 227882 CDS NP_826041.1 29831407 1211098 5914570..5915580 1 NC_003155.4 probably geranylgeranyl pyrophosphate synthase; polyprenyl diphosphate synthase 5915580 grcC 1211098 grcC Streptomyces avermitilis MA-4680 polyprenyl diphosphate synthase NP_826041.1 5914570 D 227882 CDS NP_826042.1 29831408 1215586 5915733..5916761 1 NC_003155.4 hypothetical protein 5916761 1215586 SAV_4865 Streptomyces avermitilis MA-4680 hypothetical protein NP_826042.1 5915733 D 227882 CDS NP_826043.1 29831409 1215587 5917037..5918266 1 NC_003155.4 PF03548: Outer membrane lipoprotein carrier protein LolA; hypothetical protein 5918266 1215587 SAV_4866 Streptomyces avermitilis MA-4680 hypothetical protein NP_826043.1 5917037 D 227882 CDS NP_826044.1 29831410 1215588 5918301..5919341 1 NC_003155.4 ABC transporter ATP-binding protein 5919341 1215588 SAV_4867 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_826044.1 5918301 D 227882 CDS NP_826045.1 29831411 1215589 5919328..5920221 1 NC_003155.4 ABC transporter permease 5920221 1215589 SAV_4868 Streptomyces avermitilis MA-4680 ABC transporter permease NP_826045.1 5919328 D 227882 CDS NP_826046.1 29831412 1215590 complement(5920258..5920842) 1 NC_003155.4 PF02525: Flavodoxin-like fold; hypothetical protein 5920842 1215590 SAV_4869 Streptomyces avermitilis MA-4680 hypothetical protein NP_826046.1 5920258 R 227882 CDS NP_826047.1 29831413 1215591 complement(5921048..5921746) 1 NC_003155.4 hypothetical protein 5921746 1215591 SAV_4870 Streptomyces avermitilis MA-4680 hypothetical protein NP_826047.1 5921048 R 227882 CDS NP_826048.1 29831414 1215592 5921949..5923703 1 NC_003155.4 hypothetical protein 5923703 1215592 SAV_4871 Streptomyces avermitilis MA-4680 hypothetical protein NP_826048.1 5921949 D 227882 CDS NP_826049.1 29831415 1215593 complement(5923841..5924788) 1 NC_003155.4 PF04389: Peptidase family M28; aminopeptidase 5924788 1215593 SAV_4872 Streptomyces avermitilis MA-4680 aminopeptidase NP_826049.1 5923841 R 227882 CDS NP_826050.1 29831416 1215594 complement(5924915..5925895) 1 NC_003155.4 PF00892: Integral membrane protein DUF6; hypothetical protein 5925895 1215594 SAV_4873 Streptomyces avermitilis MA-4680 hypothetical protein NP_826050.1 5924915 R 227882 CDS NP_826051.1 29831417 1215595 complement(5926028..5926882) 1 NC_003155.4 PF01113: Dihydrodipicolinate reductase, N-terminus; hypothetical protein 5926882 1215595 SAV_4874 Streptomyces avermitilis MA-4680 hypothetical protein NP_826051.1 5926028 R 227882 CDS NP_826052.1 29831418 1215596 5926972..5927445 1 NC_003155.4 PF01638: Transcriptional regulator; transcriptional regulator 5927445 1215596 SAV_4875 Streptomyces avermitilis MA-4680 transcriptional regulator NP_826052.1 5926972 D 227882 CDS NP_826053.1 29831419 1215597 complement(5927459..5928538) 1 NC_003155.4 catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin; 2-oxoglutarate ferredoxin oxidoreductase subunit beta 5928538 korB 1215597 korB Streptomyces avermitilis MA-4680 2-oxoglutarate ferredoxin oxidoreductase subunit beta NP_826053.1 5927459 R 227882 CDS NP_826054.1 29831420 1215598 complement(5928531..5930459) 1 NC_003155.4 PF01855: Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-binding domain; 2-oxoglutarate ferredoxin oxidoreductase, alpha subunit 5930459 korA 1215598 korA Streptomyces avermitilis MA-4680 2-oxoglutarate ferredoxin oxidoreductase, alpha subunit NP_826054.1 5928531 R 227882 CDS NP_826055.1 29831421 1215599 complement(5930746..5931417) 1 NC_003155.4 two-component system response regulator 5931417 1215599 SAV_4878 Streptomyces avermitilis MA-4680 two-component system response regulator NP_826055.1 5930746 R 227882 CDS NP_826056.1 29831422 1215600 complement(5931931..5933289) 1 NC_003155.4 two-component system sensor kinase 5933289 1215600 SAV_4879 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_826056.1 5931931 R 227882 CDS NP_826057.1 29831423 1215601 complement(5933658..5934899) 1 NC_003155.4 two-component system sensor kinase 5934899 1215601 SAV_4880 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_826057.1 5933658 R 227882 CDS NP_826058.1 29831424 1211099 5935153..5935593 1 NC_003155.4 similar to many chloroplastic ubiquinone dehydrogenase; NADH dehydrogenase I chain A 5935593 nuoA2 1211099 nuoA2 Streptomyces avermitilis MA-4680 NADH dehydrogenase I chain A NP_826058.1 5935153 D 227882 CDS NP_826059.1 29831425 1211100 5935584..5936195 1 NC_003155.4 similar to many eukaryotic ubiquinone dehydrogenase; NADH dehydrogenase I chain B 5936195 nuoB2 1211100 nuoB2 Streptomyces avermitilis MA-4680 NADH dehydrogenase I chain B NP_826059.1 5935584 D 227882 CDS NP_826060.1 29831426 1215602 5936192..5937706 1 NC_003155.4 PF00329: Respiratory-chain NADH dehydrogenase, 30 Kd subunit; NADH dehydrogenase 5937706 1215602 SAV_4883 Streptomyces avermitilis MA-4680 NADH dehydrogenase NP_826060.1 5936192 D 227882 CDS NP_826061.1 29831427 1211101 5937703..5938671 1 NC_003155.4 NADH dehydrogenase I chain H 5938671 nuoH2 1211101 nuoH2 Streptomyces avermitilis MA-4680 NADH dehydrogenase I chain H NP_826061.1 5937703 D 227882 CDS NP_826062.1 29831428 1211102 5938674..5939324 1 NC_003155.4 NADH dehydrogenase I chain I 5939324 nuoI2 1211102 nuoI2 Streptomyces avermitilis MA-4680 NADH dehydrogenase I chain I NP_826062.1 5938674 D 227882 CDS NP_826063.1 29831429 1211103 5939321..5939944 1 NC_003155.4 NADH dehydrogenase I chain J 5939944 nuoJ2 1211103 nuoJ2 Streptomyces avermitilis MA-4680 NADH dehydrogenase I chain J NP_826063.1 5939321 D 227882 CDS NP_826064.1 29831430 1211104 5939944..5940333 1 NC_003155.4 NADH dehydrogenase I chain K 5940333 nuoK2 1211104 nuoK2 Streptomyces avermitilis MA-4680 NADH dehydrogenase I chain K NP_826064.1 5939944 D 227882 CDS NP_826065.1 29831431 1211105 5940330..5942321 1 NC_003155.4 NADH dehydrogenase I chain L 5942321 nuoL2 1211105 nuoL2 Streptomyces avermitilis MA-4680 NADH dehydrogenase I chain L NP_826065.1 5940330 D 227882 CDS NP_826066.1 29831432 1211106 5942328..5943911 1 NC_003155.4 PF05921: Actinomycete protein of unknown function (DUF875); NADH dehydrogenase I chain M 5943911 nuoM2 1211106 nuoM2 Streptomyces avermitilis MA-4680 NADH dehydrogenase I chain M NP_826066.1 5942328 D 227882 CDS NP_826067.1 29831433 1211107 5943908..5945407 1 NC_003155.4 NADH dehydrogenase I chain N 5945407 nuoN2 1211107 nuoN2 Streptomyces avermitilis MA-4680 NADH dehydrogenase I chain N NP_826067.1 5943908 D 227882 CDS NP_826068.1 29831434 1215603 5945620..5946483 1 NC_003155.4 putative metalloprotease; heat shock protein HtpX 5946483 htpX1 1215603 htpX1 Streptomyces avermitilis MA-4680 heat shock protein HtpX NP_826068.1 5945620 D 227882 CDS NP_826069.1 29831435 1215604 5946480..5946872 1 NC_003155.4 PF03733: Domain of unknown function (DUF307); hypothetical protein 5946872 1215604 SAV_4892 Streptomyces avermitilis MA-4680 hypothetical protein NP_826069.1 5946480 D 227882 CDS NP_826070.1 29831436 1215605 5946999..5947565 1 NC_003155.4 hypothetical protein 5947565 1215605 SAV_4893 Streptomyces avermitilis MA-4680 hypothetical protein NP_826070.1 5946999 D 227882 CDS NP_826071.1 29831437 1215606 complement(5947634..5948902) 1 NC_003155.4 amino acid transporter 5948902 1215606 SAV_4894 Streptomyces avermitilis MA-4680 amino acid transporter NP_826071.1 5947634 R 227882 CDS NP_826072.1 29831438 1215607 5949050..5949316 1 NC_003155.4 PF04226: Transglycosylase associated protein; hypothetical protein 5949316 1215607 SAV_4895 Streptomyces avermitilis MA-4680 hypothetical protein NP_826072.1 5949050 D 227882 CDS NP_826073.1 29831439 1215608 complement(5949458..5949946) 1 NC_003155.4 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; putative nucleotide-binding protein 5949946 1215608 SAV_4896 Streptomyces avermitilis MA-4680 putative nucleotide-binding protein NP_826073.1 5949458 R 227882 CDS NP_826074.1 29831440 1215609 complement(5952467..5953648) 1 NC_003155.4 PF01546: Peptidase family M20/M25/M40; amidohydrolase 5953648 amiB 1215609 amiB Streptomyces avermitilis MA-4680 amidohydrolase NP_826074.1 5952467 R 227882 CDS NP_826075.1 29831441 1215610 complement(5954090..5954746) 1 NC_003155.4 PF00106: short chain dehydrogenase; hypothetical protein 5954746 1215610 SAV_4898 Streptomyces avermitilis MA-4680 hypothetical protein NP_826075.1 5954090 R 227882 CDS NP_826076.1 29831442 1215611 complement(5954988..5956229) 1 NC_003155.4 PF01979: Amidohydrolase family; hydrolase 5956229 1215611 SAV_4899 Streptomyces avermitilis MA-4680 hydrolase NP_826076.1 5954988 R 227882 CDS NP_826077.1 29831443 1211111 5956882..5957046 1 NC_003155.4 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 5957046 rpmG 1211111 rpmG Streptomyces avermitilis MA-4680 50S ribosomal protein L33 NP_826077.1 5956882 D 227882 CDS NP_826078.1 29831444 1215612 5957202..5957654 1 NC_003155.4 PF05921: Actinomycete protein of unknown function (DUF875); hypothetical protein 5957654 1215612 SAV_4901 Streptomyces avermitilis MA-4680 hypothetical protein NP_826078.1 5957202 D 227882 CDS NP_826079.1 29831445 1215613 5957657..5958085 1 NC_003155.4 PF01575: MaoC like domain; hypothetical protein 5958085 1215613 SAV_4902 Streptomyces avermitilis MA-4680 hypothetical protein NP_826079.1 5957657 D 227882 CDS NP_826080.1 29831446 1215614 5958310..5958879 1 NC_003155.4 TetR family transcriptional regulator 5958879 1215614 SAV_4903 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_826080.1 5958310 D 227882 CDS NP_826081.1 29831447 1215615 5958993..5960462 1 NC_003155.4 drug resistance, PF07690: Major Facilitator Superfamily; transmembrane efflux protein 5960462 1215615 SAV_4904 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_826081.1 5958993 D 227882 CDS NP_826082.1 29831448 1211112 5960568..5961662 1 NC_003155.4 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 5961662 murB 1211112 murB Streptomyces avermitilis MA-4680 UDP-N-acetylenolpyruvoylglucosamine reductase NP_826082.1 5960568 D 227882 CDS NP_826083.1 29831449 1211113 complement(5961860..5962888) 1 NC_003155.4 catalyzes the formation of inosine from adenosine; adenosine deaminase 5962888 add4 1211113 add4 Streptomyces avermitilis MA-4680 adenosine deaminase NP_826083.1 5961860 R 227882 CDS NP_826084.1 29831450 1211114 complement(5963056..5964282) 1 NC_003155.4 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 5964282 aspC1 1211114 aspC1 Streptomyces avermitilis MA-4680 aspartate aminotransferase NP_826084.1 5963056 R 227882 CDS NP_826085.1 29831451 1211116 5964712..5964999 1 NC_003155.4 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 5964999 secE 1211116 secE Streptomyces avermitilis MA-4680 preprotein translocase subunit SecE NP_826085.1 5964712 D 227882 CDS NP_826086.1 29831452 1211117 5965077..5965940 1 NC_003155.4 transcription antitermination protein 5965940 nusG 1211117 nusG Streptomyces avermitilis MA-4680 transcription antitermination protein NP_826086.1 5965077 D 227882 CDS NP_826087.1 29831453 1211118 5966111..5966545 1 NC_003155.4 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 5966545 rplK 1211118 rplK Streptomyces avermitilis MA-4680 50S ribosomal protein L11 NP_826087.1 5966111 D 227882 CDS NP_826088.1 29831454 1211119 5966625..5967350 1 NC_003155.4 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 5967350 rplA 1211119 rplA Streptomyces avermitilis MA-4680 50S ribosomal protein L1 NP_826088.1 5966625 D 227882 CDS NP_826089.1 29831455 1211120 5967982..5968512 1 NC_003155.4 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 5968512 rplJ 1211120 rplJ Streptomyces avermitilis MA-4680 50S ribosomal protein L10 NP_826089.1 5967982 D 227882 CDS NP_826090.1 29831456 1211121 5968622..5969005 1 NC_003155.4 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 5969005 rplL 1211121 rplL Streptomyces avermitilis MA-4680 50S ribosomal protein L7/L12 NP_826090.1 5968622 D 227882 CDS NP_826091.1 29831457 1211122 5969568..5973113 1 NC_003155.4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 5973113 rpoB 1211122 rpoB Streptomyces avermitilis MA-4680 DNA-directed RNA polymerase subunit beta NP_826091.1 5969568 D 227882 CDS NP_826092.1 29831458 1211123 5973224..5977123 1 NC_003155.4 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 5977123 rpoC 1211123 rpoC Streptomyces avermitilis MA-4680 DNA-directed RNA polymerase subunit beta' NP_826092.1 5973224 D 227882 CDS NP_826093.1 29831459 1215616 5977160..5977861 1 NC_003155.4 hypothetical protein 5977861 1215616 SAV_4916 Streptomyces avermitilis MA-4680 hypothetical protein NP_826093.1 5977160 D 227882 CDS NP_826094.1 29831460 1211124 5978149..5978520 1 NC_003155.4 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 5978520 rpsL 1211124 rpsL Streptomyces avermitilis MA-4680 30S ribosomal protein S12 NP_826094.1 5978149 D 227882 CDS NP_826095.1 29831461 1211125 5978523..5978993 1 NC_003155.4 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 5978993 rpsG 1211125 rpsG Streptomyces avermitilis MA-4680 30S ribosomal protein S7 NP_826095.1 5978523 D 227882 CDS NP_826096.1 29831462 1211126 5979033..5981162 1 NC_003155.4 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 5981162 fusA1 1211126 fusA1 Streptomyces avermitilis MA-4680 elongation factor G NP_826096.1 5979033 D 227882 CDS NP_826097.1 29831463 1211127 5981306..5982499 1 NC_003155.4 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 5982499 tuf 1211127 tuf Streptomyces avermitilis MA-4680 elongation factor Tu NP_826097.1 5981306 D 227882 CDS NP_826098.1 29831464 1215617 5982592..5982705 1 NC_003155.4 hypothetical protein 5982705 1215617 SAV_4921 Streptomyces avermitilis MA-4680 hypothetical protein NP_826098.1 5982592 D 227882 CDS NP_826099.1 29831465 1215618 complement(5982754..5983359) 1 NC_003155.4 PF06821: Protein of unknown function (DUF1234); hypothetical protein 5983359 1215618 SAV_4922 Streptomyces avermitilis MA-4680 hypothetical protein NP_826099.1 5982754 R 227882 CDS NP_826100.1 29831466 1215619 5983411..5984361 1 NC_003155.4 LysR family transcriptional regulator 5984361 1215619 SAV_4923 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_826100.1 5983411 D 227882 CDS NP_826101.1 29831467 1215620 complement(5984370..5986484) 1 NC_003155.4 PF02585: Uncharacterised LmbE-like protein, COG2120; hypothetical protein 5986484 1215620 SAV_4924 Streptomyces avermitilis MA-4680 hypothetical protein NP_826101.1 5984370 R 227882 CDS NP_826102.1 29831468 1211128 5987138..5987446 1 NC_003155.4 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 5987446 rpsJ 1211128 rpsJ Streptomyces avermitilis MA-4680 30S ribosomal protein S10 NP_826102.1 5987138 D 227882 CDS NP_826103.1 29831469 1211129 5987464..5988108 1 NC_003155.4 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 5988108 rplC 1211129 rplC Streptomyces avermitilis MA-4680 50S ribosomal protein L3 NP_826103.1 5987464 D 227882 CDS NP_826104.1 29831470 1211130 5988114..5988779 1 NC_003155.4 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 5988779 rplD 1211130 rplD Streptomyces avermitilis MA-4680 50S ribosomal protein L4 NP_826104.1 5988114 D 227882 CDS NP_826105.1 29831471 1211131 5988779..5989195 1 NC_003155.4 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 5989195 rplW 1211131 rplW Streptomyces avermitilis MA-4680 50S ribosomal protein L23 NP_826105.1 5988779 D 227882 CDS NP_826106.1 29831472 1211132 5989235..5990071 1 NC_003155.4 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 5990071 rplB 1211132 rplB Streptomyces avermitilis MA-4680 50S ribosomal protein L2 NP_826106.1 5989235 D 227882 CDS NP_826107.1 29831473 1211133 5990084..5990365 1 NC_003155.4 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 5990365 rpsS 1211133 rpsS Streptomyces avermitilis MA-4680 30S ribosomal protein S19 NP_826107.1 5990084 D 227882 CDS NP_826108.1 29831474 1211134 5990408..5990755 1 NC_003155.4 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 5990755 rplV 1211134 rplV Streptomyces avermitilis MA-4680 50S ribosomal protein L22 NP_826108.1 5990408 D 227882 CDS NP_826109.1 29831475 1211135 5990755..5991582 1 NC_003155.4 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 5991582 rpsC 1211135 rpsC Streptomyces avermitilis MA-4680 30S ribosomal protein S3 NP_826109.1 5990755 D 227882 CDS NP_826110.1 29831476 1211136 5991589..5992008 1 NC_003155.4 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 5992008 rplP 1211136 rplP Streptomyces avermitilis MA-4680 50S ribosomal protein L16 NP_826110.1 5991589 D 227882 CDS NP_826111.1 29831477 1211137 5992008..5992232 1 NC_003155.4 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 5992232 rpmC 1211137 rpmC Streptomyces avermitilis MA-4680 50S ribosomal protein L29 NP_826111.1 5992008 D 227882 CDS NP_826112.1 29831478 1211138 5992232..5992516 1 NC_003155.4 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 5992516 rpsQ 1211138 rpsQ Streptomyces avermitilis MA-4680 30S ribosomal protein S17 NP_826112.1 5992232 D 227882 CDS NP_826113.1 29831479 1211139 5992620..5992988 1 NC_003155.4 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 5992988 rplN 1211139 rplN Streptomyces avermitilis MA-4680 50S ribosomal protein L14 NP_826113.1 5992620 D 227882 CDS NP_826114.1 29831480 1211140 5992991..5993314 1 NC_003155.4 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 5993314 rplX 1211140 rplX Streptomyces avermitilis MA-4680 50S ribosomal protein L24 NP_826114.1 5992991 D 227882 CDS NP_826115.1 29831481 1211141 5993314..5993871 1 NC_003155.4 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 5993871 rplE 1211141 rplE Streptomyces avermitilis MA-4680 50S ribosomal protein L5 NP_826115.1 5993314 D 227882 CDS NP_826116.1 29831482 1211142 5993877..5994062 1 NC_003155.4 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif; 30S ribosomal protein S14 5994062 rpsN 1211142 rpsN Streptomyces avermitilis MA-4680 30S ribosomal protein S14 NP_826116.1 5993877 D 227882 CDS NP_826117.1 29831483 1211143 5994274..5994672 1 NC_003155.4 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 5994672 rpsH 1211143 rpsH Streptomyces avermitilis MA-4680 30S ribosomal protein S8 NP_826117.1 5994274 D 227882 CDS NP_826118.1 29831484 1211144 5994697..5995236 1 NC_003155.4 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 5995236 rplF 1211144 rplF Streptomyces avermitilis MA-4680 50S ribosomal protein L6 NP_826118.1 5994697 D 227882 CDS NP_826119.1 29831485 1211145 5995240..5995623 1 NC_003155.4 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 5995623 rplR 1211145 rplR Streptomyces avermitilis MA-4680 50S ribosomal protein L18 NP_826119.1 5995240 D 227882 CDS NP_826120.1 29831486 1211146 5995665..5996270 1 NC_003155.4 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 5996270 rpsE 1211146 rpsE Streptomyces avermitilis MA-4680 30S ribosomal protein S5 NP_826120.1 5995665 D 227882 CDS NP_826121.1 29831487 1211147 5996273..5996455 1 NC_003155.4 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 5996455 rpmD 1211147 rpmD Streptomyces avermitilis MA-4680 50S ribosomal protein L30 NP_826121.1 5996273 D 227882 CDS NP_826122.1 29831488 1211148 5996458..5996913 1 NC_003155.4 late assembly protein; 50S ribosomal protein L15 5996913 rplO 1211148 rplO Streptomyces avermitilis MA-4680 50S ribosomal protein L15 NP_826122.1 5996458 D 227882 CDS NP_826123.1 29831489 1211149 5997158..5998474 1 NC_003155.4 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 5998474 secY 1211149 secY Streptomyces avermitilis MA-4680 preprotein translocase subunit SecY NP_826123.1 5997158 D 227882 CDS NP_826124.1 29831490 1211150 5998474..5999136 1 NC_003155.4 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 5999136 adk 1211150 adk Streptomyces avermitilis MA-4680 adenylate kinase NP_826124.1 5998474 D 227882 CDS NP_826125.1 29831491 1211151 5999283..6000119 1 NC_003155.4 PF00557: metallopeptidase family M24; methionine aminopeptidase 6000119 map3 1211151 map3 Streptomyces avermitilis MA-4680 methionine aminopeptidase NP_826125.1 5999283 D 227882 CDS NP_826126.1 29831492 1211152 6000287..6000508 1 NC_003155.4 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 6000508 infA 1211152 infA Streptomyces avermitilis MA-4680 translation initiation factor IF-1 NP_826126.1 6000287 D 227882 CDS NP_826127.1 29831493 1211153 6000568..6000681 1 NC_003155.4 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 6000681 rpmJ 1211153 rpmJ Streptomyces avermitilis MA-4680 50S ribosomal protein L36 NP_826127.1 6000568 D 227882 CDS NP_826128.1 29831494 1211154 6000885..6001265 1 NC_003155.4 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 6001265 rpsM 1211154 rpsM Streptomyces avermitilis MA-4680 30S ribosomal protein S13 NP_826128.1 6000885 D 227882 CDS NP_826129.1 29831495 1211155 6001363..6001767 1 NC_003155.4 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 6001767 rpsK 1211155 rpsK Streptomyces avermitilis MA-4680 30S ribosomal protein S11 NP_826129.1 6001363 D 227882 CDS NP_826130.1 29831496 1211156 6001910..6002932 1 NC_003155.4 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 6002932 rpoA 1211156 rpoA Streptomyces avermitilis MA-4680 DNA-directed RNA polymerase subunit alpha NP_826130.1 6001910 D 227882 CDS NP_826131.1 29831497 1211157 6003114..6003617 1 NC_003155.4 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 6003617 rplQ 1211157 rplQ Streptomyces avermitilis MA-4680 50S ribosomal protein L17 NP_826131.1 6003114 D 227882 CDS NP_826132.1 29831498 1211158 6003707..6004564 1 NC_003155.4 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 6004564 truA 1211158 truA Streptomyces avermitilis MA-4680 tRNA pseudouridine synthase A NP_826132.1 6003707 D 227882 CDS NP_826133.1 29831499 1215621 complement(6004569..6005456) 1 NC_003155.4 hypothetical protein 6005456 1215621 SAV_4956 Streptomyces avermitilis MA-4680 hypothetical protein NP_826133.1 6004569 R 227882 CDS NP_826134.1 29831500 1211159 6005829..6006272 1 NC_003155.4 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 6006272 rplM 1211159 rplM Streptomyces avermitilis MA-4680 50S ribosomal protein L13 NP_826134.1 6005829 D 227882 CDS NP_826135.1 29831501 1211160 6006315..6006836 1 NC_003155.4 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 6006836 rpsI 1211160 rpsI Streptomyces avermitilis MA-4680 30S ribosomal protein S9 NP_826135.1 6006315 D 227882 CDS NP_826136.1 29831502 1211161 6007048..6008406 1 NC_003155.4 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 6008406 glmM 1211161 glmM Streptomyces avermitilis MA-4680 phosphoglucosamine mutase NP_826136.1 6007048 D 227882 CDS NP_826137.1 29831503 1215622 complement(6008474..6009427) 1 NC_003155.4 PF04087: Domain of unknown function (DUF389); hypothetical protein 6009427 1215622 SAV_4960 Streptomyces avermitilis MA-4680 hypothetical protein NP_826137.1 6008474 R 227882 CDS NP_826138.1 29831504 1211162 complement(6009444..6010433) 1 NC_003155.4 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 6010433 coaA 1211162 coaA Streptomyces avermitilis MA-4680 pantothenate kinase NP_826138.1 6009444 R 227882 CDS NP_826139.1 29831505 1215623 6010591..6010848 1 NC_003155.4 hypothetical protein 6010848 1215623 SAV_4962 Streptomyces avermitilis MA-4680 hypothetical protein NP_826139.1 6010591 D 227882 CDS NP_826140.1 29831506 1211163 6011012..6012859 1 NC_003155.4 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 6012859 glmS1 1211163 glmS1 Streptomyces avermitilis MA-4680 glucosamine--fructose-6-phosphate aminotransferase NP_826140.1 6011012 D 227882 CDS NP_826141.1 29831507 1211164 6013029..6013400 1 NC_003155.4 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 6013400 acpS 1211164 acpS Streptomyces avermitilis MA-4680 4'-phosphopantetheinyl transferase NP_826141.1 6013029 D 227882 CDS NP_826142.1 29831508 1215624 6013441..6014871 1 NC_003155.4 PF03853: YjeF-related protein N-terminus; hypothetical protein 6014871 1215624 SAV_4965 Streptomyces avermitilis MA-4680 hypothetical protein NP_826142.1 6013441 D 227882 CDS NP_826143.1 29831509 1215625 6014923..6016140 1 NC_003155.4 PF03734: ErfK/YbiS/YcfS/YnhG; hypothetical protein 6016140 1215625 SAV_4966 Streptomyces avermitilis MA-4680 hypothetical protein NP_826143.1 6014923 D 227882 CDS NP_826144.1 29831510 1211165 6016209..6017384 1 NC_003155.4 alanine racemase 6017384 alr 1211165 alr Streptomyces avermitilis MA-4680 alanine racemase NP_826144.1 6016209 D 227882 CDS NP_826145.1 29831511 1215626 6017475..6018725 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 6018725 1215626 SAV_4968 Streptomyces avermitilis MA-4680 hydrolase NP_826145.1 6017475 D 227882 CDS NP_826146.1 29831512 1215627 6018685..6019212 1 NC_003155.4 PF02367: Uncharacterised P-loop hydrolase UPF0079; hypothetical protein 6019212 1215627 SAV_4969 Streptomyces avermitilis MA-4680 hypothetical protein NP_826146.1 6018685 D 227882 CDS NP_826147.1 29831513 1215628 6019468..6019644 1 NC_003155.4 hypothetical protein 6019644 1215628 SAV_4970 Streptomyces avermitilis MA-4680 hypothetical protein NP_826147.1 6019468 D 227882 CDS NP_826148.1 29831514 1215629 complement(6019730..6020284) 1 NC_003155.4 hypothetical protein 6020284 1215629 SAV_4971 Streptomyces avermitilis MA-4680 hypothetical protein NP_826148.1 6019730 R 227882 CDS NP_826149.1 29831515 1215630 6020407..6021054 1 NC_003155.4 PF00814: glycoprotease family; hypothetical protein 6021054 1215630 SAV_4972 Streptomyces avermitilis MA-4680 hypothetical protein NP_826149.1 6020407 D 227882 CDS NP_826150.1 29831516 1215631 6021072..6021554 1 NC_003155.4 probably ribosomal-protein-alanine N-acetyltransferase; ribosomal-protein-alanine N-acetyltransferase 6021554 1215631 SAV_4973 Streptomyces avermitilis MA-4680 ribosomal-protein-alanine N-acetyltransferase NP_826150.1 6021072 D 227882 CDS NP_826151.1 29831517 1211166 6021547..6022671 1 NC_003155.4 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease 6022671 gcp 1211166 gcp Streptomyces avermitilis MA-4680 putative DNA-binding/iron metalloprotein/AP endonuclease NP_826151.1 6021547 D 227882 CDS NP_826152.1 29831518 1215632 6022668..6022925 1 NC_003155.4 hypothetical protein 6022925 1215632 SAV_4975 Streptomyces avermitilis MA-4680 hypothetical protein NP_826152.1 6022668 D 227882 CDS NP_826153.1 29831519 1215633 6023026..6023868 1 NC_003155.4 DNA-binding protein 6023868 1215633 SAV_4976 Streptomyces avermitilis MA-4680 DNA-binding protein NP_826153.1 6023026 D 227882 CDS NP_826154.1 29831520 1215634 6023865..6024116 1 NC_003155.4 PF04149: Domain of unknown function (DUF397); hypothetical protein 6024116 1215634 SAV_4977 Streptomyces avermitilis MA-4680 hypothetical protein NP_826154.1 6023865 D 227882 CDS NP_826155.1 29831521 1215635 6024202..6025221 1 NC_003155.4 LacI family transcriptional regulator 6025221 1215635 SAV_4978 Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_826155.1 6024202 D 227882 CDS NP_826156.1 29831522 1215636 6025409..6026713 1 NC_003155.4 sugar ABC transporter substrate-binding protein 6026713 1215636 SAV_4979 Streptomyces avermitilis MA-4680 sugar ABC transporter substrate-binding protein NP_826156.1 6025409 D 227882 CDS NP_826157.1 29831523 1215637 6026723..6027775 1 NC_003155.4 sugar ABC transporter permease 6027775 1215637 SAV_4980 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_826157.1 6026723 D 227882 CDS NP_826158.1 29831524 1215638 6027772..6028668 1 NC_003155.4 sugar ABC transporter permease 6028668 1215638 SAV_4981 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_826158.1 6027772 D 227882 CDS NP_826159.1 29831525 1211167 6028705..6030933 1 NC_003155.4 xylan 1,4-beta-xylosidase 6030933 xynB2 1211167 xynB2 Streptomyces avermitilis MA-4680 xylan 1,4-beta-xylosidase NP_826159.1 6028705 D 227882 CDS NP_826160.1 29831526 1215639 6031078..6032187 1 NC_003155.4 LacI family transcriptional regulator 6032187 1215639 SAV_4983 Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_826160.1 6031078 D 227882 CDS NP_826161.1 29831527 1215640 6032380..6033735 1 NC_003155.4 PF00331: Glycosyl hydrolase family 10; beta-1,4-xylanase 6033735 1215640 SAV_4984 Streptomyces avermitilis MA-4680 beta-1,4-xylanase NP_826161.1 6032380 D 227882 CDS NP_826162.1 29831528 1215641 6033808..6034893 1 NC_003155.4 transcriptional regulator 6034893 1215641 SAV_4985 Streptomyces avermitilis MA-4680 transcriptional regulator NP_826162.1 6033808 D 227882 CDS NP_826163.1 29831529 1215642 6035075..6035431 1 NC_003155.4 PF04946: DGPF domain; hypothetical protein 6035431 1215642 SAV_4986 Streptomyces avermitilis MA-4680 hypothetical protein NP_826163.1 6035075 D 227882 CDS NP_826164.1 29831530 1211168 6035525..6036799 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 6036799 sig43 1211168 sig43 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_826164.1 6035525 D 227882 CDS NP_826165.1 29831531 1215643 complement(6036912..6038084) 1 NC_003155.4 hypothetical protein 6038084 1215643 SAV_4988 Streptomyces avermitilis MA-4680 hypothetical protein NP_826165.1 6036912 R 227882 CDS NP_826166.1 29831532 1215644 6038220..6039095 1 NC_003155.4 PF01522: Polysaccharide deacetylase; polysaccharide deacetylase 6039095 1215644 SAV_4989 Streptomyces avermitilis MA-4680 polysaccharide deacetylase NP_826166.1 6038220 D 227882 CDS NP_826167.1 29831533 1215645 6039092..6039922 1 NC_003155.4 PF01522: Polysaccharide deacetylase; polysaccharide deacetylase 6039922 1215645 SAV_4990 Streptomyces avermitilis MA-4680 polysaccharide deacetylase NP_826167.1 6039092 D 227882 CDS NP_826168.1 29831534 1211169 6040496..6040804 1 NC_003155.4 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 6040804 groES 1211169 groES Streptomyces avermitilis MA-4680 co-chaperonin GroES NP_826168.1 6040496 D 227882 CDS NP_826169.1 29831535 1211170 6040941..6042569 1 NC_003155.4 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is not essential for growth; chaperonin GroEL 6042569 groEL 1211170 groEL Streptomyces avermitilis MA-4680 chaperonin GroEL NP_826169.1 6040941 D 227882 CDS NP_826170.1 29831536 1215646 complement(6042693..6043442) 1 NC_003155.4 PF07366: Protein of unknown function (DUF1486); hypothetical protein 6043442 1215646 SAV_4993 Streptomyces avermitilis MA-4680 hypothetical protein NP_826170.1 6042693 R 227882 CDS NP_826171.1 29831537 1215647 complement(6043471..6044244) 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 6044244 1215647 SAV_4994 Streptomyces avermitilis MA-4680 dehydrogenase NP_826171.1 6043471 R 227882 CDS NP_826172.1 29831538 1215648 complement(6044407..6045075) 1 NC_003155.4 PF03473: MOSC domain; hypothetical protein 6045075 1215648 SAV_4995 Streptomyces avermitilis MA-4680 hypothetical protein NP_826172.1 6044407 R 227882 CDS NP_826173.1 29831539 1215649 6045156..6046052 1 NC_003155.4 LysR family transcriptional regulator 6046052 1215649 SAV_4996 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_826173.1 6045156 D 227882 CDS NP_826174.1 29831540 1211171 complement(6046179..6046508) 1 NC_003155.4 PF02467: Transcription factor WhiB; WhiB-family transcriptional regulator 6046508 wblB 1211171 wblB Streptomyces avermitilis MA-4680 WhiB-family transcriptional regulator NP_826174.1 6046179 R 227882 CDS NP_826175.1 29831541 1215650 6046898..6047509 1 NC_003155.4 two-component system response regulator 6047509 1215650 SAV_4998 Streptomyces avermitilis MA-4680 two-component system response regulator NP_826175.1 6046898 D 227882 CDS NP_826176.1 29831542 1211172 6047808..6048383 1 NC_003155.4 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this protein is involved in expression of ribosome-associated gene products in stationary phase; RNA polymerase sigma factor SigD 6048383 sig44 1211172 sig44 Streptomyces avermitilis MA-4680 RNA polymerase sigma factor SigD NP_826176.1 6047808 D 227882 CDS NP_826177.1 29831543 1211173 6048664..6050172 1 NC_003155.4 inosine-5'-monophosphate dehydrogenase 6050172 guaB1 1211173 guaB1 Streptomyces avermitilis MA-4680 inosine-5'-monophosphate dehydrogenase NP_826177.1 6048664 D 227882 CDS NP_826178.1 29831544 1211174 6050311..6051435 1 NC_003155.4 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase 6051435 guaB2 1211174 guaB2 Streptomyces avermitilis MA-4680 inosine 5-monophosphate dehydrogenase NP_826178.1 6050311 D 227882 CDS NP_826179.1 29831545 1215651 complement(6052108..6053316) 1 NC_003155.4 PF00984: UDP-glucose/GDP-mannose dehydrogenase family, central domain; UDP-glucose/GDP-mannose dehydrogenase 6053316 1215651 SAV_5002 Streptomyces avermitilis MA-4680 UDP-glucose/GDP-mannose dehydrogenase NP_826179.1 6052108 R 227882 CDS NP_826180.1 29831546 1211175 6053578..6055284 1 NC_003155.4 glycerol-3-phosphate dehydrogenase 6055284 glpD 1211175 glpD Streptomyces avermitilis MA-4680 glycerol-3-phosphate dehydrogenase NP_826180.1 6053578 D 227882 CDS NP_826181.1 29831547 1215652 complement(6055377..6056438) 1 NC_003155.4 PF00144: Beta-lactamase; beta-lactamase 6056438 1215652 SAV_5004 Streptomyces avermitilis MA-4680 beta-lactamase NP_826181.1 6055377 R 227882 CDS NP_826182.1 29831548 1211176 6056589..6058769 1 NC_003155.4 serine/threonine protein kinase 6058769 pkn18 1211176 pkn18 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_826182.1 6056589 D 227882 CDS NP_826183.1 29831549 1211177 6058940..6061621 1 NC_003155.4 serine/threonine protein kinase 6061621 pkn19 1211177 pkn19 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_826183.1 6058940 D 227882 CDS NP_826184.1 29831550 1211178 6061938..6063581 1 NC_003155.4 serine/threonine protein kinase 6063581 pkn20 1211178 pkn20 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_826184.1 6061938 D 227882 CDS NP_826185.1 29831551 1211179 6063790..6064947 1 NC_003155.4 serine/threonine protein kinase 6064947 pkn21 1211179 pkn21 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_826185.1 6063790 D 227882 CDS NP_826186.1 29831552 1215653 6065086..6065475 1 NC_003155.4 hypothetical protein 6065475 1215653 SAV_5009 Streptomyces avermitilis MA-4680 hypothetical protein NP_826186.1 6065086 D 227882 CDS NP_826187.1 29831553 1211180 6065586..6067322 1 NC_003155.4 serine/threonine protein kinase 6067322 pkn22 1211180 pkn22 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_826187.1 6065586 D 227882 CDS NP_826188.1 29831554 1215654 complement(6067364..6068167) 1 NC_003155.4 hypothetical protein 6068167 1215654 SAV_5011 Streptomyces avermitilis MA-4680 hypothetical protein NP_826188.1 6067364 R 227882 CDS NP_826189.1 29831555 1215655 complement(6068609..6068794) 1 NC_003155.4 PF04149: Domain of unknown function (DUF397); hypothetical protein 6068794 1215655 SAV_5012 Streptomyces avermitilis MA-4680 hypothetical protein NP_826189.1 6068609 R 227882 CDS NP_826190.1 29831556 1215656 complement(6068806..6069657) 1 NC_003155.4 DNA-binding protein 6069657 1215656 SAV_5013 Streptomyces avermitilis MA-4680 DNA-binding protein NP_826190.1 6068806 R 227882 CDS NP_826191.1 29831557 1215657 6069909..6070397 1 NC_003155.4 regulatory protein 6070397 1215657 SAV_5014 Streptomyces avermitilis MA-4680 regulatory protein NP_826191.1 6069909 D 227882 CDS NP_826192.1 29831558 1215658 6070502..6071875 1 NC_003155.4 PF00781: Diacylglycerol kinase catalytic domain (presumed); hypothetical protein 6071875 1215658 SAV_5015 Streptomyces avermitilis MA-4680 hypothetical protein NP_826192.1 6070502 D 227882 CDS NP_826193.1 29831559 1215659 6072117..6073748 1 NC_003155.4 NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; succinic semialdehyde dehydrogenase 6073748 gabD2 1215659 gabD2 Streptomyces avermitilis MA-4680 succinic semialdehyde dehydrogenase NP_826193.1 6072117 D 227882 CDS NP_826194.1 29831560 1215660 6073813..6075618 1 NC_003155.4 PF01266: FAD dependent oxidoreductase; cholesterol oxidase 6075618 choD 1215660 choD Streptomyces avermitilis MA-4680 cholesterol oxidase NP_826194.1 6073813 D 227882 CDS NP_826195.1 29831561 1215661 6075922..6076683 1 NC_003155.4 hypothetical protein 6076683 1215661 SAV_5018 Streptomyces avermitilis MA-4680 hypothetical protein NP_826195.1 6075922 D 227882 CDS NP_826196.1 29831562 1215662 complement(6077378..6077662) 1 NC_003155.4 hypothetical protein 6077662 1215662 SAV_5019 Streptomyces avermitilis MA-4680 hypothetical protein NP_826196.1 6077378 R 227882 CDS NP_826197.1 29831563 1215663 complement(6077928..6078473) 1 NC_003155.4 PF04138: GtrA-like protein; hypothetical protein 6078473 1215663 SAV_5020 Streptomyces avermitilis MA-4680 hypothetical protein NP_826197.1 6077928 R 227882 CDS NP_826198.1 29831564 1211181 6078590..6079813 1 NC_003155.4 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 6079813 purK 1211181 purK Streptomyces avermitilis MA-4680 phosphoribosylaminoimidazole carboxylase ATPase subunit NP_826198.1 6078590 D 227882 CDS NP_826199.1 29831565 1211182 6079810..6080343 1 NC_003155.4 phosphoribosylaminoimidazole carboxylase catalytic subunit 6080343 purE 1211182 purE Streptomyces avermitilis MA-4680 phosphoribosylaminoimidazole carboxylase catalytic subunit NP_826199.1 6079810 D 227882 CDS NP_826200.1 29831566 1215664 6080349..6081542 1 NC_003155.4 PF01244: Membrane dipeptidase (Peptidase family M19); dipeptidase 6081542 1215664 SAV_5023 Streptomyces avermitilis MA-4680 dipeptidase NP_826200.1 6080349 D 227882 CDS NP_826201.1 29831567 1215665 complement(6081579..6081971) 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein 6081971 1215665 SAV_5024 Streptomyces avermitilis MA-4680 hypothetical protein NP_826201.1 6081579 R 227882 CDS NP_826202.1 29831568 1211183 complement(6082205..6083548) 1 NC_003155.4 UDP-glucose 6-dehydrogenase 6083548 udgA 1211183 udgA Streptomyces avermitilis MA-4680 UDP-glucose 6-dehydrogenase NP_826202.1 6082205 R 227882 CDS NP_826203.1 29831569 1211184 6083724..6084881 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 6084881 fadE1 1211184 fadE1 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_826203.1 6083724 D 227882 CDS NP_826204.1 29831570 1215666 complement(6084970..6085605) 1 NC_003155.4 PF00702: haloacid dehalogenase-like hydrolase; hypothetical protein 6085605 1215666 SAV_5027 Streptomyces avermitilis MA-4680 hypothetical protein NP_826204.1 6084970 R 227882 CDS NP_826205.1 29831571 1215667 complement(6085605..6086798) 1 NC_003155.4 PF03816: Cell envelope-related transcriptional attenuator domain; transcriptional regulator 6086798 1215667 SAV_5028 Streptomyces avermitilis MA-4680 transcriptional regulator NP_826205.1 6085605 R 227882 CDS NP_826206.1 29831572 1215668 6086994..6087617 1 NC_003155.4 PF03061: Thioesterase superfamily; acyl-CoA hydrolase 6087617 1215668 SAV_5029 Streptomyces avermitilis MA-4680 acyl-CoA hydrolase NP_826206.1 6086994 D 227882 CDS NP_826207.1 29831573 1215669 complement(6087680..6089206) 1 NC_003155.4 PF03816: Cell envelope-related transcriptional attenuator domain; transcriptional regulator 6089206 1215669 SAV_5030 Streptomyces avermitilis MA-4680 transcriptional regulator NP_826207.1 6087680 R 227882 CDS NP_826208.1 29831574 1215670 6089279..6090307 1 NC_003155.4 PF00535: Glycosyl transferase; glycosyl transferase 6090307 1215670 SAV_5031 Streptomyces avermitilis MA-4680 glycosyl transferase NP_826208.1 6089279 D 227882 CDS NP_826209.1 29831575 1215671 complement(6090362..6092104) 1 NC_003155.4 PF03816: Cell envelope-related transcriptional attenuator domain; transcriptional regulator 6092104 1215671 SAV_5032 Streptomyces avermitilis MA-4680 transcriptional regulator NP_826209.1 6090362 R 227882 CDS NP_826210.1 29831576 1215672 complement(6092429..6093952) 1 NC_003155.4 PF03816: Cell envelope-related transcriptional attenuator domain; transcriptional regulator 6093952 1215672 SAV_5033 Streptomyces avermitilis MA-4680 transcriptional regulator NP_826210.1 6092429 R 227882 CDS NP_826211.1 29831577 1215673 complement(6094412..6095662) 1 NC_003155.4 PF03816: Cell envelope-related transcriptional attenuator domain; transcriptional regulator 6095662 1215673 SAV_5034 Streptomyces avermitilis MA-4680 transcriptional regulator NP_826211.1 6094412 R 227882 CDS NP_826212.1 29831578 1215674 complement(6095910..6096674) 1 NC_003155.4 hypothetical protein 6096674 1215674 SAV_5035 Streptomyces avermitilis MA-4680 hypothetical protein NP_826212.1 6095910 R 227882 CDS NP_826213.1 29831579 1215675 6096814..6098190 1 NC_003155.4 PF01510: N-acetylmuramoyl-L-alanine amidase; hypothetical protein 6098190 1215675 SAV_5036 Streptomyces avermitilis MA-4680 hypothetical protein NP_826213.1 6096814 D 227882 CDS NP_826214.1 29831580 1211185 6098346..6099428 1 NC_003155.4 PF00483: Nucleotidyl transferase; nucleotide phosphorylase 6099428 rmlA 1211185 rmlA Streptomyces avermitilis MA-4680 nucleotide phosphorylase NP_826214.1 6098346 D 227882 CDS NP_826215.1 29831581 1215676 complement(6099570..6100580) 1 NC_003155.4 hypothetical protein 6100580 1215676 SAV_5038 Streptomyces avermitilis MA-4680 hypothetical protein NP_826215.1 6099570 R 227882 CDS NP_826216.1 29831582 1215677 complement(6100654..6101925) 1 NC_003155.4 catalyzes the addition of gamma linked glutamate to 7,8-didemethyl-8-hydroxy-5-deazariboflavin coenzyme F420-0); F420-0--gamma-glutamyl ligase 6101925 1215677 SAV_5039 Streptomyces avermitilis MA-4680 F420-0--gamma-glutamyl ligase NP_826216.1 6100654 R 227882 CDS NP_826217.1 29831583 1215678 complement(6102195..6103154) 1 NC_003155.4 catalyzes the formation of the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) and GMP from actyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); LPPG:FO 2-phospho-L-lactate transferase 6103154 1215678 SAV_5040 Streptomyces avermitilis MA-4680 LPPG:FO 2-phospho-L-lactate transferase NP_826217.1 6102195 R 227882 CDS NP_826218.1 29831584 1215679 complement(6103189..6103716) 1 NC_003155.4 PF05995: cysteine dioxygenase type I; cysteine dioxygenase 6103716 cdo2 1215679 cdo2 Streptomyces avermitilis MA-4680 cysteine dioxygenase NP_826218.1 6103189 R 227882 CDS NP_826219.1 29831585 1211186 6104412..6104675 1 NC_003155.4 PF02467: Transcription factor WhiB; WhiB-family transcriptional regulator 6104675 whiB 1211186 whiB Streptomyces avermitilis MA-4680 WhiB-family transcriptional regulator NP_826219.1 6104412 D 227882 CDS NP_826220.1 29831586 1215680 6104897..6108574 1 NC_003155.4 PF00535: Glycosyl transferase; hypothetical protein 6108574 1215680 SAV_5043 Streptomyces avermitilis MA-4680 hypothetical protein NP_826220.1 6104897 D 227882 CDS NP_826221.1 29831587 1215681 6108571..6110079 1 NC_003155.4 protein 6110079 1215681 SAV_5044 Streptomyces avermitilis MA-4680 protein NP_826221.1 6108571 D 227882 CDS NP_826222.1 29831588 1215682 complement(6110158..6110730) 1 NC_003155.4 hypothetical protein 6110730 1215682 SAV_5045 Streptomyces avermitilis MA-4680 hypothetical protein NP_826222.1 6110158 R 227882 CDS NP_826223.1 29831589 1215683 6110912..6111385 1 NC_003155.4 hypothetical protein 6111385 1215683 SAV_5046 Streptomyces avermitilis MA-4680 hypothetical protein NP_826223.1 6110912 D 227882 CDS NP_826224.1 29831590 1215684 6111641..6113257 1 NC_003155.4 L-lactate permease 6113257 lldP 1215684 lldP Streptomyces avermitilis MA-4680 L-lactate permease NP_826224.1 6111641 D 227882 CDS NP_826225.1 29831591 1211187 6113505..6114872 1 NC_003155.4 converts mannose-6-phosphate to mannose-1-phosphate; the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells; phosphomannomutase/phosphoglucomutase 6114872 manB 1211187 manB Streptomyces avermitilis MA-4680 phosphomannomutase/phosphoglucomutase NP_826225.1 6113505 D 227882 CDS NP_826226.1 29831592 1215685 6115063..6115233 1 NC_003155.4 PF03966: Protein of unknown function (DUF343); hypothetical protein 6115233 1215685 SAV_5049 Streptomyces avermitilis MA-4680 hypothetical protein NP_826226.1 6115063 D 227882 CDS NP_826227.1 29831593 1215686 6115265..6116392 1 NC_003155.4 hypothetical protein 6116392 1215686 SAV_5050 Streptomyces avermitilis MA-4680 hypothetical protein NP_826227.1 6115265 D 227882 CDS NP_826228.1 29831594 1211188 6116496..6117647 1 NC_003155.4 mannose-6-phosphate isomerase 6117647 manA 1211188 manA Streptomyces avermitilis MA-4680 mannose-6-phosphate isomerase NP_826228.1 6116496 D 227882 CDS NP_826229.1 29831595 1215687 6117765..6118748 1 NC_003155.4 transport protein 6118748 1215687 SAV_5052 Streptomyces avermitilis MA-4680 transport protein NP_826229.1 6117765 D 227882 CDS NP_826230.1 29831596 1211189 6119333..6120790 1 NC_003155.4 catalyzes the formation of L-homocysteine from S-adenosyl-L-homocysteine; S-adenosyl-L-homocysteine hydrolase 6120790 sahH 1211189 sahH Streptomyces avermitilis MA-4680 S-adenosyl-L-homocysteine hydrolase NP_826230.1 6119333 D 227882 CDS NP_826231.1 29831597 1215688 6120938..6121552 1 NC_003155.4 PF06271: RDD family; hypothetical protein 6121552 1215688 SAV_5054 Streptomyces avermitilis MA-4680 hypothetical protein NP_826231.1 6120938 D 227882 CDS NP_826232.1 29831598 1215689 complement(6121647..6122654) 1 NC_003155.4 PF06271: RDD family; hypothetical protein 6122654 1215689 SAV_5055 Streptomyces avermitilis MA-4680 hypothetical protein NP_826232.1 6121647 R 227882 CDS NP_826233.1 29831599 1215690 6122773..6123780 1 NC_003155.4 PF01944: Integral membrane protein DUF95; hypothetical protein 6123780 1215690 SAV_5056 Streptomyces avermitilis MA-4680 hypothetical protein NP_826233.1 6122773 D 227882 CDS NP_826234.1 29831600 1215691 complement(6129669..6130979) 1 NC_003155.4 PF01882: Protein of unknown function DUF58; hypothetical protein 6130979 1215691 SAV_5057 Streptomyces avermitilis MA-4680 hypothetical protein NP_826234.1 6129669 R 227882 CDS NP_826235.1 29831601 1215692 complement(6130979..6131971) 1 NC_003155.4 regulatory protein 6131971 1215692 SAV_5058 Streptomyces avermitilis MA-4680 regulatory protein NP_826235.1 6130979 R 227882 CDS NP_826236.1 29831602 1215693 complement(6131968..6133107) 1 NC_003155.4 protein 6133107 1215693 SAV_5059 Streptomyces avermitilis MA-4680 protein NP_826236.1 6131968 R 227882 CDS NP_826237.1 29831603 1215694 complement(6133158..6133877) 1 NC_003155.4 integral membrane protein 6133877 1215694 SAV_5060 Streptomyces avermitilis MA-4680 integral membrane protein NP_826237.1 6133158 R 227882 CDS NP_826238.1 29831604 1215695 complement(6133912..6135261) 1 NC_003155.4 PF07415: Gammaherpesvirus latent membrane protein (LMP2) protein; integral membrane protein 6135261 1215695 SAV_5061 Streptomyces avermitilis MA-4680 integral membrane protein NP_826238.1 6133912 R 227882 CDS NP_826239.1 29831605 1211193 6135405..6136553 1 NC_003155.4 initiation factor eIF-2B alpha subunit 6136553 eif1 1211193 eif1 Streptomyces avermitilis MA-4680 initiation factor eIF-2B alpha subunit NP_826239.1 6135405 D 227882 CDS NP_826240.1 29831606 1215696 6136558..6137247 1 NC_003155.4 two-component system response regulator 6137247 1215696 SAV_5063 Streptomyces avermitilis MA-4680 two-component system response regulator NP_826240.1 6136558 D 227882 CDS NP_826241.1 29831607 1215697 6137249..6139327 1 NC_003155.4 two-component system sensor kinase 6139327 1215697 SAV_5064 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_826241.1 6137249 D 227882 CDS NP_826242.1 29831608 1215698 6139317..6141149 1 NC_003155.4 lipoprotein LpqB 6141149 1215698 SAV_5065 Streptomyces avermitilis MA-4680 lipoprotein LpqB NP_826242.1 6139317 D 227882 CDS NP_826243.1 29831609 1215699 6141156..6142175 1 NC_003155.4 PF00156: Phosphoribosyl transferase domain; hypothetical protein 6142175 1215699 SAV_5066 Streptomyces avermitilis MA-4680 hypothetical protein NP_826243.1 6141156 D 227882 CDS NP_826244.1 29831610 1215700 6142323..6143183 1 NC_003155.4 PF02482: Sigma 54 modulation protein / S30EA ribosomal protein; hypothetical protein 6143183 1215700 SAV_5067 Streptomyces avermitilis MA-4680 hypothetical protein NP_826244.1 6142323 D 227882 CDS NP_826245.1 29831611 1215701 6143389..6144135 1 NC_003155.4 two-component system response regulator 6144135 1215701 SAV_5068 Streptomyces avermitilis MA-4680 two-component system response regulator NP_826245.1 6143389 D 227882 CDS NP_826246.1 29831612 1215702 complement(6144163..6145365) 1 NC_003155.4 PF06224: Protein of unknown function (DUF1006); hypothetical protein 6145365 1215702 SAV_5069 Streptomyces avermitilis MA-4680 hypothetical protein NP_826246.1 6144163 R 227882 CDS NP_826247.1 29831613 1215703 complement(6145429..6145998) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 6145998 1215703 SAV_5070 Streptomyces avermitilis MA-4680 acetyltransferase NP_826247.1 6145429 R 227882 CDS NP_826248.1 29831614 1211194 6146233..6149052 1 NC_003155.4 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 6149052 secA1 1211194 secA1 Streptomyces avermitilis MA-4680 preprotein translocase subunit SecA NP_826248.1 6146233 D 227882 CDS NP_826249.1 29831615 1215704 complement(6149247..6149516) 1 NC_003155.4 hypothetical protein 6149516 1215704 SAV_5072 Streptomyces avermitilis MA-4680 hypothetical protein NP_826249.1 6149247 R 227882 CDS NP_826250.1 29831616 1215705 6150095..6150610 1 NC_003155.4 hypothetical protein 6150610 1215705 SAV_5073 Streptomyces avermitilis MA-4680 hypothetical protein NP_826250.1 6150095 D 227882 CDS NP_826251.1 29831617 1215706 6150756..6151430 1 NC_003155.4 phosphatase 6151430 1215706 SAV_5074 Streptomyces avermitilis MA-4680 phosphatase NP_826251.1 6150756 D 227882 CDS NP_826252.1 29831618 1215707 6152169..6157106 1 NC_003155.4 PF05088: Bacterial NAD-glutamate dehydrogenase; NAD-glutamate dehydrogenase 6157106 1215707 SAV_5075 Streptomyces avermitilis MA-4680 NAD-glutamate dehydrogenase NP_826252.1 6152169 D 227882 CDS NP_826253.1 29831619 1215708 6157319..6157807 1 NC_003155.4 PF04138: GtrA-like protein; hypothetical protein 6157807 1215708 SAV_5076 Streptomyces avermitilis MA-4680 hypothetical protein NP_826253.1 6157319 D 227882 CDS NP_826254.1 29831620 1215709 6157791..6159287 1 NC_003155.4 integral membrane protein 6159287 1215709 SAV_5077 Streptomyces avermitilis MA-4680 integral membrane protein NP_826254.1 6157791 D 227882 CDS NP_826255.1 29831621 1215710 complement(6159441..6161141) 1 NC_003155.4 transferase 6161141 1215710 SAV_5078 Streptomyces avermitilis MA-4680 transferase NP_826255.1 6159441 R 227882 CDS NP_826256.1 29831622 1211195 complement(6161138..6163360) 1 NC_003155.4 CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase 6163360 tagF 1211195 tagF Streptomyces avermitilis MA-4680 CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase NP_826256.1 6161138 R 227882 CDS NP_826257.1 29831623 1211196 complement(6163464..6164453) 1 NC_003155.4 teichoic acid translocation transport system; ABC transporter ATP-binding protein 6164453 tagH 1211196 tagH Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_826257.1 6163464 R 227882 CDS NP_826258.1 29831624 1215711 complement(6164446..6165405) 1 NC_003155.4 ABC transporter permease 6165405 1215711 SAV_5081 Streptomyces avermitilis MA-4680 ABC transporter permease NP_826258.1 6164446 R 227882 CDS NP_826259.1 29831625 1215712 6165643..6166281 1 NC_003155.4 TetR family transcriptional regulator 6166281 1215712 SAV_5082 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_826259.1 6165643 D 227882 CDS NP_826260.1 29831626 1215713 complement(6166489..6167544) 1 NC_003155.4 PF03747: ADP-ribosylglycohydrolase; ribosylglycoyhydrolase 6167544 1215713 SAV_5083 Streptomyces avermitilis MA-4680 ribosylglycoyhydrolase NP_826260.1 6166489 R 227882 CDS NP_826261.1 29831627 1215714 complement(6167549..6168172) 1 NC_003155.4 TetR family transcriptional regulator 6168172 1215714 SAV_5084 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_826261.1 6167549 R 227882 CDS NP_826262.1 29831628 1215715 6168271..6169239 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 6169239 1215715 SAV_5085 Streptomyces avermitilis MA-4680 dehydrogenase NP_826262.1 6168271 D 227882 CDS NP_826263.1 29831629 1211197 complement(6169307..6170287) 1 NC_003155.4 UDP-glucose 4-epimerase 6170287 galE3 1211197 galE3 Streptomyces avermitilis MA-4680 UDP-glucose 4-epimerase NP_826263.1 6169307 R 227882 CDS NP_826264.1 29831630 1215716 complement(6170365..6171960) 1 NC_003155.4 transferase 6171960 1215716 SAV_5087 Streptomyces avermitilis MA-4680 transferase NP_826264.1 6170365 R 227882 CDS NP_826265.1 29831631 1215717 complement(6172005..6173273) 1 NC_003155.4 hypothetical protein 6173273 1215717 SAV_5088 Streptomyces avermitilis MA-4680 hypothetical protein NP_826265.1 6172005 R 227882 CDS NP_826266.1 29831632 1215718 6173367..6174929 1 NC_003155.4 hypothetical protein 6174929 1215718 SAV_5089 Streptomyces avermitilis MA-4680 hypothetical protein NP_826266.1 6173367 D 227882 CDS NP_826267.1 29831633 1215719 complement(6175007..6175510) 1 NC_003155.4 MarR family transcriptional regulator 6175510 1215719 SAV_5090 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_826267.1 6175007 R 227882 CDS NP_826268.1 29831634 1215720 6175639..6176052 1 NC_003155.4 organic hydroperoxide resistance protein 6176052 ohrB2 1215720 ohrB2 Streptomyces avermitilis MA-4680 organic hydroperoxide resistance protein NP_826268.1 6175639 D 227882 CDS NP_826269.1 29831635 1215721 complement(6176259..6177581) 1 NC_003155.4 integral membrane protein 6177581 1215721 SAV_5092 Streptomyces avermitilis MA-4680 integral membrane protein NP_826269.1 6176259 R 227882 CDS NP_826270.1 29831636 1215722 complement(6177590..6179788) 1 NC_003155.4 PF04464: CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; glycosyl transferase 6179788 1215722 SAV_5093 Streptomyces avermitilis MA-4680 glycosyl transferase NP_826270.1 6177590 R 227882 CDS NP_826271.1 29831637 1215723 complement(6179794..6181983) 1 NC_003155.4 PF04464: CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; glycosyl transferase 6181983 1215723 SAV_5094 Streptomyces avermitilis MA-4680 glycosyl transferase NP_826271.1 6179794 R 227882 CDS NP_826272.1 29831638 1215724 complement(6182113..6184449) 1 NC_003155.4 PF04464: CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; glycosyl transferase 6184449 1215724 SAV_5095 Streptomyces avermitilis MA-4680 glycosyl transferase NP_826272.1 6182113 R 227882 CDS NP_826273.1 29831639 1215725 complement(6184571..6185452) 1 NC_003155.4 sugar ABC transporter permease 6185452 1215725 SAV_5096 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_826273.1 6184571 R 227882 CDS NP_826274.1 29831640 1215726 complement(6185449..6186729) 1 NC_003155.4 sugar ABC transporter permease 6186729 1215726 SAV_5097 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_826274.1 6185449 R 227882 CDS NP_826275.1 29831641 1215727 complement(6186823..6188214) 1 NC_003155.4 sugar ABC transporter substrate-binding protein 6188214 1215727 SAV_5098 Streptomyces avermitilis MA-4680 sugar ABC transporter substrate-binding protein NP_826275.1 6186823 R 227882 CDS NP_826276.1 29831642 1215728 complement(6188365..6192633) 1 NC_003155.4 PF00498: FHA domain; hypothetical protein 6192633 1215728 SAV_5099 Streptomyces avermitilis MA-4680 hypothetical protein NP_826276.1 6188365 R 227882 CDS NP_826277.1 29831643 1211198 6193092..6194813 1 NC_003155.4 serine/threonine protein kinase 6194813 pkn23 1211198 pkn23 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_826277.1 6193092 D 227882 CDS NP_826278.1 29831644 1211199 6194969..6196210 1 NC_003155.4 serine/threonine protein kinase 6196210 pkn24 1211199 pkn24 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_826278.1 6194969 D 227882 CDS NP_826279.1 29831645 1211200 6196323..6197429 1 NC_003155.4 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 6197429 prfB 1211200 prfB Streptomyces avermitilis MA-4680 peptide chain release factor 2 NP_826279.1 6196323 D 227882 CDS NP_826280.1 29831646 1215729 6197736..6198566 1 NC_003155.4 protein 6198566 1215729 SAV_5103 Streptomyces avermitilis MA-4680 protein NP_826280.1 6197736 D 227882 CDS NP_826281.1 29831647 1211201 6199189..6199878 1 NC_003155.4 ABC transporter ATP-binding protein; cell division ATP-binding protein 6199878 ftsE 1211201 ftsE Streptomyces avermitilis MA-4680 cell division ATP-binding protein NP_826281.1 6199189 D 227882 CDS NP_826282.1 29831648 1211202 6199908..6200825 1 NC_003155.4 cell division protein 6200825 ftsX 1211202 ftsX Streptomyces avermitilis MA-4680 cell division protein NP_826282.1 6199908 D 227882 CDS NP_826283.1 29831649 1215730 6200893..6202062 1 NC_003155.4 PF03572: Peptidase family S41; carboxy-terminal processing protease precursor 6202062 1215730 SAV_5106 Streptomyces avermitilis MA-4680 carboxy-terminal processing protease precursor NP_826283.1 6200893 D 227882 CDS NP_826284.1 29831650 1211203 6202121..6202654 1 NC_003155.4 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 6202654 smpB 1211203 smpB Streptomyces avermitilis MA-4680 SsrA-binding protein NP_826284.1 6202121 D 227882 CDS NP_826285.1 29831651 1215731 6203529..6204158 1 NC_003155.4 hypothetical protein 6204158 1215731 SAV_5108 Streptomyces avermitilis MA-4680 hypothetical protein NP_826285.1 6203529 D 227882 CDS NP_826286.1 29831652 1215732 complement(6204339..6204635) 1 NC_003155.4 hypothetical protein 6204635 1215732 SAV_5109 Streptomyces avermitilis MA-4680 hypothetical protein NP_826286.1 6204339 R 227882 CDS NP_826287.1 29831653 1215733 6205038..6205949 1 NC_003155.4 phosphotransferase 6205949 1215733 SAV_5110 Streptomyces avermitilis MA-4680 phosphotransferase NP_826287.1 6205038 D 227882 CDS NP_826288.1 29831654 1211205 6206060..6207481 1 NC_003155.4 CYP184A1; cytochrome P450 6207481 cyp21 1211205 cyp21 Streptomyces avermitilis MA-4680 cytochrome P450 NP_826288.1 6206060 D 227882 CDS NP_826289.1 29831655 1215734 complement(6207447..6208703) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 6208703 1215734 SAV_5112 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_826289.1 6207447 R 227882 CDS NP_826290.1 29831656 1215735 6208934..6209899 1 NC_003155.4 LysR family transcriptional regulator 6209899 1215735 SAV_5113 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_826290.1 6208934 D 227882 CDS NP_826291.1 29831657 1215736 6209993..6211513 1 NC_003155.4 hypothetical protein 6211513 1215736 SAV_5114 Streptomyces avermitilis MA-4680 hypothetical protein NP_826291.1 6209993 D 227882 CDS NP_826292.1 29831658 1215737 6211513..6213765 1 NC_003155.4 bi-functional transferase/deacetylase 6213765 1215737 SAV_5115 Streptomyces avermitilis MA-4680 bi-functional transferase/deacetylase NP_826292.1 6211513 D 227882 CDS NP_826293.1 29831659 1215738 6213762..6215018 1 NC_003155.4 PF01757: Acyltransferase family; integral membrane protein 6215018 1215738 SAV_5116 Streptomyces avermitilis MA-4680 integral membrane protein NP_826293.1 6213762 D 227882 CDS NP_826294.1 29831660 1215739 complement(6215339..6215887) 1 NC_003155.4 hypothetical protein 6215887 1215739 SAV_5117 Streptomyces avermitilis MA-4680 hypothetical protein NP_826294.1 6215339 R 227882 CDS NP_826295.1 29831661 1215740 complement(6216000..6216446) 1 NC_003155.4 PF03364: Streptomyces cyclase/dehydrase; hypothetical protein 6216446 1215740 SAV_5118 Streptomyces avermitilis MA-4680 hypothetical protein NP_826295.1 6216000 R 227882 CDS NP_826296.1 29831662 1211206 6216715..6218106 1 NC_003155.4 PF07690: Major Facilitator Superfamily; nitrate extrusion protein 6218106 narK 1211206 narK Streptomyces avermitilis MA-4680 nitrate extrusion protein NP_826296.1 6216715 D 227882 CDS NP_826297.1 29831663 1215741 6218210..6219370 1 NC_003155.4 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; bifunctional uroporphyrinogen-III synthetase/response regulator domain protein 6219370 1215741 SAV_5120 Streptomyces avermitilis MA-4680 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein NP_826297.1 6218210 D 227882 CDS NP_826298.1 29831664 1215742 complement(6219319..6219873) 1 NC_003155.4 hypothetical protein 6219873 1215742 SAV_5121 Streptomyces avermitilis MA-4680 hypothetical protein NP_826298.1 6219319 R 227882 CDS NP_826299.1 29831665 1215743 6220123..6220710 1 NC_003155.4 PF07336: Protein of unknown function (DUF1470); hypothetical protein 6220710 1215743 SAV_5122 Streptomyces avermitilis MA-4680 hypothetical protein NP_826299.1 6220123 D 227882 CDS NP_826300.1 29831666 1211207 6221200..6221796 1 NC_003155.4 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein regulates polyketide synthases and or membrane proteins; RNA polymerase sigma factor SigL 6221796 sig45 1211207 sig45 Streptomyces avermitilis MA-4680 RNA polymerase sigma factor SigL NP_826300.1 6221200 D 227882 CDS NP_826301.1 29831667 1215744 6221799..6222617 1 NC_003155.4 hypothetical protein 6222617 1215744 SAV_5124 Streptomyces avermitilis MA-4680 hypothetical protein NP_826301.1 6221799 D 227882 CDS NP_826302.1 29831668 1215745 6222701..6225211 1 NC_003155.4 ATP-dependent helicase 6225211 1215745 SAV_5125 Streptomyces avermitilis MA-4680 ATP-dependent helicase NP_826302.1 6222701 D 227882 CDS NP_826303.1 29831669 1215746 6225718..6227151 1 NC_003155.4 PF03949: Malic enzyme, NAD binding domain; malate oxidoreductase 6227151 1215746 SAV_5126 Streptomyces avermitilis MA-4680 malate oxidoreductase NP_826303.1 6225718 D 227882 CDS NP_826304.1 29831670 1211208 6227508..6227789 1 NC_003155.4 PF00216: Bacterial DNA-binding protein; DNA-binding protein HU 1 6227789 hup 1211208 hup Streptomyces avermitilis MA-4680 DNA-binding protein HU 1 NP_826304.1 6227508 D 227882 CDS NP_826305.1 29831671 1211209 complement(6227970..6229316) 1 NC_003155.4 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 6229316 murA2 1211209 murA2 Streptomyces avermitilis MA-4680 UDP-N-acetylglucosamine 1-carboxyvinyltransferase NP_826305.1 6227970 R 227882 CDS NP_826306.1 29831672 1215747 6229586..6230167 1 NC_003155.4 PF02622: Uncharacterized ACR, COG1678; hypothetical protein 6230167 1215747 SAV_5129 Streptomyces avermitilis MA-4680 hypothetical protein NP_826306.1 6229586 D 227882 CDS NP_826307.1 29831673 1215748 6230197..6230493 1 NC_003155.4 hypothetical protein 6230493 1215748 SAV_5130 Streptomyces avermitilis MA-4680 hypothetical protein NP_826307.1 6230197 D 227882 CDS NP_826308.1 29831674 1215749 6230779..6232119 1 NC_003155.4 sugar ABC transporter substrate-binding protein 6232119 1215749 SAV_5131 Streptomyces avermitilis MA-4680 sugar ABC transporter substrate-binding protein NP_826308.1 6230779 D 227882 CDS NP_826309.1 29831675 1215750 6232124..6233086 1 NC_003155.4 sugar ABC transporter permease 6233086 1215750 SAV_5132 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_826309.1 6232124 D 227882 CDS NP_826310.1 29831676 1215751 6233083..6233928 1 NC_003155.4 sugar ABC transporter permease 6233928 1215751 SAV_5133 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_826310.1 6233083 D 227882 CDS NP_826311.1 29831677 1215752 6233930..6235663 1 NC_003155.4 beta-N-acetylhexosaminidase 6235663 nagZ3 1215752 nagZ3 Streptomyces avermitilis MA-4680 beta-N-acetylhexosaminidase NP_826311.1 6233930 D 227882 CDS NP_826312.1 29831678 1215753 6235873..6236793 1 NC_003155.4 PF00941: FAD binding domain in molybdopterin dehydrogenase; dehydrogenase 6236793 1215753 SAV_5135 Streptomyces avermitilis MA-4680 dehydrogenase NP_826312.1 6235873 D 227882 CDS NP_826313.1 29831679 1215754 6236790..6238352 1 NC_003155.4 PF01799: [2Fe-2S] binding domain; hypothetical protein 6238352 1215754 SAV_5136 Streptomyces avermitilis MA-4680 hypothetical protein NP_826313.1 6236790 D 227882 CDS NP_826314.1 29831680 1215755 6238349..6240655 1 NC_003155.4 PF02738: Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding domain; dehydrogenase 6240655 1215755 SAV_5137 Streptomyces avermitilis MA-4680 dehydrogenase NP_826314.1 6238349 D 227882 CDS NP_826315.1 29831681 1215756 6240993..6242183 1 NC_003155.4 hypothetical protein 6242183 1215756 SAV_5138 Streptomyces avermitilis MA-4680 hypothetical protein NP_826315.1 6240993 D 227882 CDS NP_826316.1 29831682 1211211 6242641..6244095 1 NC_003155.4 PF07690: Major Facilitator Superfamily; multidrug resistance efflux protein 6244095 ebrB 1211211 ebrB Streptomyces avermitilis MA-4680 multidrug resistance efflux protein NP_826316.1 6242641 D 227882 CDS NP_826317.1 29831683 1211212 6244408..6246204 1 NC_003155.4 PF04851: Type III restriction enzyme, res subunit; protein involving differentiation 6246204 sdrA 1211212 sdrA Streptomyces avermitilis MA-4680 protein involving differentiation NP_826317.1 6244408 D 227882 CDS NP_826318.1 29831684 1211213 6246638..6247279 1 NC_003155.4 PF01614: Bacterial transcriptional regulator; differentiation regulon transcriptional regulator 6247279 sdrB 1211213 sdrB Streptomyces avermitilis MA-4680 differentiation regulon transcriptional regulator NP_826318.1 6246638 D 227882 CDS NP_826319.1 29831685 1211214 6247582..6248376 1 NC_003155.4 PF05362: Lon protease (S16) C-terminal proteolytic domain; protein 6248376 sdrC 1211214 sdrC Streptomyces avermitilis MA-4680 protein NP_826319.1 6247582 D 227882 CDS NP_826320.1 29831686 1215757 complement(6248588..6249226) 1 NC_003155.4 transcription regulator ArsR 6249226 1215757 SAV_5143 Streptomyces avermitilis MA-4680 transcription regulator ArsR NP_826320.1 6248588 R 227882 CDS NP_826321.1 29831687 1215758 complement(6249242..6250204) 1 NC_003155.4 ABC transporter substrate-binding protein 6250204 1215758 SAV_5144 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_826321.1 6249242 R 227882 CDS NP_826322.1 29831688 1215759 complement(6250201..6251031) 1 NC_003155.4 ABC transporter permease 6251031 1215759 SAV_5145 Streptomyces avermitilis MA-4680 ABC transporter permease NP_826322.1 6250201 R 227882 CDS NP_826323.1 29831689 1215760 complement(6251028..6252341) 1 NC_003155.4 ABC transporter ATP-binding protein 6252341 1215760 SAV_5146 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_826323.1 6251028 R 227882 CDS NP_826324.1 29831690 1215761 complement(6252334..6252981) 1 NC_003155.4 ABC transporter permease 6252981 1215761 SAV_5147 Streptomyces avermitilis MA-4680 ABC transporter permease NP_826324.1 6252334 R 227882 CDS NP_826325.1 29831691 1215762 complement(6253005..6253517) 1 NC_003155.4 transcription regulator AsnC 6253517 1215762 SAV_5148 Streptomyces avermitilis MA-4680 transcription regulator AsnC NP_826325.1 6253005 R 227882 CDS NP_826326.1 29831692 1211215 6253610..6254755 1 NC_003155.4 ochronotic pigment biosynthesis, PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; 4-hydroxyphenylpyruvate dioxygenase 6254755 hpd 1211215 hpd Streptomyces avermitilis MA-4680 4-hydroxyphenylpyruvate dioxygenase NP_826326.1 6253610 D 227882 CDS NP_826327.1 29831693 1215763 complement(6254901..6256490) 1 NC_003155.4 PF00515: TPR Domain; hypothetical protein 6256490 1215763 SAV_5150 Streptomyces avermitilis MA-4680 hypothetical protein NP_826327.1 6254901 R 227882 CDS NP_826328.1 29831694 1215764 6256583..6257998 1 NC_003155.4 similar to glycolate oxidase: PF01565: FAD binding domain; (S)-2-hydroxy-acid oxidase 6257998 glcD2 1215764 glcD2 Streptomyces avermitilis MA-4680 (S)-2-hydroxy-acid oxidase NP_826328.1 6256583 D 227882 CDS NP_826329.1 29831695 1215765 6258237..6259847 1 NC_003155.4 PF06271: RDD family; hypothetical protein 6259847 1215765 SAV_5152 Streptomyces avermitilis MA-4680 hypothetical protein NP_826329.1 6258237 D 227882 CDS NP_826330.1 29831696 1215766 6260266..6260712 1 NC_003155.4 PF06271: RDD family; hypothetical protein 6260712 1215766 SAV_5153 Streptomyces avermitilis MA-4680 hypothetical protein NP_826330.1 6260266 D 227882 CDS NP_826331.1 29831697 1215767 complement(6260892..6261176) 1 NC_003155.4 hypothetical protein 6261176 1215767 SAV_5154 Streptomyces avermitilis MA-4680 hypothetical protein NP_826331.1 6260892 R 227882 CDS NP_826332.1 29831698 1215768 6261636..6263981 1 NC_003155.4 PF05547: Immune inhibitor A peptidase M6; protease 6263981 1215768 SAV_5155 Streptomyces avermitilis MA-4680 protease NP_826332.1 6261636 D 227882 CDS NP_826333.1 29831699 1215769 6264103..6264486 1 NC_003155.4 hypothetical protein 6264486 1215769 SAV_5156 Streptomyces avermitilis MA-4680 hypothetical protein NP_826333.1 6264103 D 227882 CDS NP_826334.1 29831700 1211216 complement(6264870..6265454) 1 NC_003155.4 nicotinamidase 6265454 pncA 1211216 pncA Streptomyces avermitilis MA-4680 nicotinamidase NP_826334.1 6264870 R 227882 CDS NP_826335.1 29831701 1211217 complement(6265776..6267104) 1 NC_003155.4 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 6267104 pncB 1211217 pncB Streptomyces avermitilis MA-4680 nicotinate phosphoribosyltransferase NP_826335.1 6265776 R 227882 CDS NP_826336.1 29831702 1215770 6267279..6267596 1 NC_003155.4 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 6267596 clpS 1215770 clpS Streptomyces avermitilis MA-4680 ATP-dependent Clp protease adaptor protein ClpS NP_826336.1 6267279 D 227882 CDS NP_826337.1 29831703 1215771 6267609..6268214 1 NC_003155.4 hypothetical protein 6268214 1215771 SAV_5160 Streptomyces avermitilis MA-4680 hypothetical protein NP_826337.1 6267609 D 227882 CDS NP_826338.1 29831704 1215772 6268547..6269998 1 NC_003155.4 proline permease 6269998 1215772 SAV_5161 Streptomyces avermitilis MA-4680 proline permease NP_826338.1 6268547 D 227882 CDS NP_826339.1 29831705 1215773 6270089..6270511 1 NC_003155.4 PF01398: Mov34/MPN/PAD-1 family; hypothetical protein 6270511 1215773 SAV_5162 Streptomyces avermitilis MA-4680 hypothetical protein NP_826339.1 6270089 D 227882 CDS NP_826340.1 29831706 1215774 6270890..6271177 1 NC_003155.4 PF02597: ThiS family; hypothetical protein 6271177 1215774 SAV_5163 Streptomyces avermitilis MA-4680 hypothetical protein NP_826340.1 6270890 D 227882 CDS NP_826341.1 29831707 1211218 6271195..6272145 1 NC_003155.4 cysteine synthase 6272145 cysM2 1211218 cysM2 Streptomyces avermitilis MA-4680 cysteine synthase NP_826341.1 6271195 D 227882 CDS NP_826342.1 29831708 1215775 complement(6272273..6272719) 1 NC_003155.4 hypothetical protein 6272719 1215775 SAV_5165 Streptomyces avermitilis MA-4680 hypothetical protein NP_826342.1 6272273 R 227882 CDS NP_826343.1 29831709 1215776 6272994..6273746 1 NC_003155.4 PF00753: Metallo-beta-lactamase superfamily; hypothetical protein 6273746 1215776 SAV_5166 Streptomyces avermitilis MA-4680 hypothetical protein NP_826343.1 6272994 D 227882 CDS NP_826344.1 29831710 1215777 complement(6273825..6275093) 1 NC_003155.4 PF02378: Phosphotransferase system, EIIC; phosphotransferase system IIC component 6275093 ptsC1 1215777 ptsC1 Streptomyces avermitilis MA-4680 phosphotransferase system IIC component NP_826344.1 6273825 R 227882 CDS NP_826345.1 29831711 1215778 complement(6275343..6276629) 1 NC_003155.4 PF02378: Phosphotransferase system, EIIC; phosphotransferase system IIC component 6276629 ptsC2 1215778 ptsC2 Streptomyces avermitilis MA-4680 phosphotransferase system IIC component NP_826345.1 6275343 R 227882 CDS NP_826346.1 29831712 1215779 6276799..6277032 1 NC_003155.4 PF00367: Phosphotransferase system, EIIB; phosphotransferase system IIB component 6277032 ptsB 1215779 ptsB Streptomyces avermitilis MA-4680 phosphotransferase system IIB component NP_826346.1 6276799 D 227882 CDS NP_826347.1 29831713 1211219 6277137..6277871 1 NC_003155.4 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 6277871 rph 1211219 rph Streptomyces avermitilis MA-4680 ribonuclease PH NP_826347.1 6277137 D 227882 CDS NP_826348.1 29831714 1215780 6277931..6278347 1 NC_003155.4 protein 6278347 1215780 SAV_5171 Streptomyces avermitilis MA-4680 protein NP_826348.1 6277931 D 227882 CDS NP_826349.1 29831715 1215781 6278382..6278984 1 NC_003155.4 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; putative deoxyribonucleotide triphosphate pyrophosphatase 6278984 1215781 SAV_5172 Streptomyces avermitilis MA-4680 putative deoxyribonucleotide triphosphate pyrophosphatase NP_826349.1 6278382 D 227882 CDS NP_826350.1 29831716 1215782 complement(6279261..6280244) 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 6280244 1215782 SAV_5173 Streptomyces avermitilis MA-4680 hydrolase NP_826350.1 6279261 R 227882 CDS NP_826351.1 29831717 1215783 6280352..6280963 1 NC_003155.4 TetR family transcriptional regulator 6280963 1215783 SAV_5174 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_826351.1 6280352 D 227882 CDS NP_826352.1 29831718 1215784 complement(6281141..6282649) 1 NC_003155.4 PF00083: Sugar (and other) transporter; osmoprotectant transporter 6282649 1215784 SAV_5175 Streptomyces avermitilis MA-4680 osmoprotectant transporter NP_826352.1 6281141 R 227882 CDS NP_826353.1 29831719 1211221 complement(6282777..6283244) 1 NC_003155.4 PF00578: AhpC/TSA family; bacterioferritin comigratory protein 6283244 bcp2 1211221 bcp2 Streptomyces avermitilis MA-4680 bacterioferritin comigratory protein NP_826353.1 6282777 R 227882 CDS NP_826354.1 29831720 1215785 6283437..6283775 1 NC_003155.4 hypothetical protein 6283775 1215785 SAV_5177 Streptomyces avermitilis MA-4680 hypothetical protein NP_826354.1 6283437 D 227882 CDS NP_826355.1 29831721 1211222 6283819..6284175 1 NC_003155.4 GroES family molecular chaperone 6284175 groES2 1211222 groES2 Streptomyces avermitilis MA-4680 GroES family molecular chaperone NP_826355.1 6283819 D 227882 CDS NP_826356.1 29831722 1211223 complement(6284295..6286541) 1 NC_003155.4 PF00912: Transglycosylase; penicillin-binding protein 6286541 pbp9 1211223 pbp9 Streptomyces avermitilis MA-4680 penicillin-binding protein NP_826356.1 6284295 R 227882 CDS NP_826357.1 29831723 1215786 6286890..6287690 1 NC_003155.4 PF06182: Protein of unknown function (DUF990); hypothetical protein 6287690 1215786 SAV_5180 Streptomyces avermitilis MA-4680 hypothetical protein NP_826357.1 6286890 D 227882 CDS NP_826358.1 29831724 1215787 6287683..6288582 1 NC_003155.4 PF06182: Protein of unknown function (DUF990); integral membrane transport protein 6288582 1215787 SAV_5181 Streptomyces avermitilis MA-4680 integral membrane transport protein NP_826358.1 6287683 D 227882 CDS NP_826359.1 29831725 1215788 6288585..6289592 1 NC_003155.4 ABC transporter ATP-binding protein 6289592 1215788 SAV_5182 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_826359.1 6288585 D 227882 CDS NP_826360.1 29831726 1215789 6289626..6290528 1 NC_003155.4 hypothetical protein 6290528 1215789 SAV_5183 Streptomyces avermitilis MA-4680 hypothetical protein NP_826360.1 6289626 D 227882 CDS NP_826361.1 29831727 1215790 complement(6290569..6291963) 1 NC_003155.4 PF00657: GDSL-like Lipase/Acylhydrolase; protein 6291963 1215790 SAV_5184 Streptomyces avermitilis MA-4680 protein NP_826361.1 6290569 R 227882 CDS NP_826362.1 29831728 1215791 6292063..6293430 1 NC_003155.4 PF04286: Protein of unknown function (DUF445); hypothetical protein 6293430 1215791 SAV_5185 Streptomyces avermitilis MA-4680 hypothetical protein NP_826362.1 6292063 D 227882 CDS NP_826363.1 29831729 1215792 6293494..6294999 1 NC_003155.4 PF07690: Major Facilitator Superfamily; sugar transport protein 6294999 1215792 SAV_5186 Streptomyces avermitilis MA-4680 sugar transport protein NP_826363.1 6293494 D 227882 CDS NP_826364.1 29831730 1215793 6295078..6295557 1 NC_003155.4 hypothetical protein 6295557 1215793 SAV_5187 Streptomyces avermitilis MA-4680 hypothetical protein NP_826364.1 6295078 D 227882 CDS NP_826365.1 29831731 1215794 complement(6295642..6296151) 1 NC_003155.4 hypothetical protein 6296151 1215794 SAV_5188 Streptomyces avermitilis MA-4680 hypothetical protein NP_826365.1 6295642 R 227882 CDS NP_826366.1 29831732 1215795 complement(6296162..6296611) 1 NC_003155.4 integral membrane protein 6296611 1215795 SAV_5189 Streptomyces avermitilis MA-4680 integral membrane protein NP_826366.1 6296162 R 227882 CDS NP_826367.1 29831733 1215796 6296882..6297907 1 NC_003155.4 AraC family transcription regulator 6297907 1215796 SAV_5190 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_826367.1 6296882 D 227882 CDS NP_826368.1 29831734 1215797 complement(6297984..6298289) 1 NC_003155.4 hypothetical protein 6298289 1215797 SAV_5191 Streptomyces avermitilis MA-4680 hypothetical protein NP_826368.1 6297984 R 227882 CDS NP_826369.1 29831735 1215798 complement(6298444..6299172) 1 NC_003155.4 hypothetical protein 6299172 1215798 SAV_5192 Streptomyces avermitilis MA-4680 hypothetical protein NP_826369.1 6298444 R 227882 CDS NP_826370.1 29831736 1215799 complement(6299385..6299759) 1 NC_003155.4 PF03995: Peptidase inhibitor family I36; hypothetical protein 6299759 1215799 SAV_5193 Streptomyces avermitilis MA-4680 hypothetical protein NP_826370.1 6299385 R 227882 CDS NP_826371.1 29831737 1215800 complement(6299976..6300449) 1 NC_003155.4 hypothetical protein 6300449 1215800 SAV_5194 Streptomyces avermitilis MA-4680 hypothetical protein NP_826371.1 6299976 R 227882 CDS NP_826372.1 29831738 1215801 6301008..6301202 1 NC_003155.4 hypothetical protein 6301202 1215801 SAV_5195 Streptomyces avermitilis MA-4680 hypothetical protein NP_826372.1 6301008 D 227882 CDS NP_826373.1 29831739 1215802 6301177..6301710 1 NC_003155.4 hypothetical protein 6301710 1215802 SAV_5196 Streptomyces avermitilis MA-4680 hypothetical protein NP_826373.1 6301177 D 227882 CDS NP_826374.1 29831740 1215803 6301736..6302587 1 NC_003155.4 DNA-binding protein 6302587 1215803 SAV_5197 Streptomyces avermitilis MA-4680 DNA-binding protein NP_826374.1 6301736 D 227882 CDS NP_826375.1 29831741 1215804 complement(6302630..6303106) 1 NC_003155.4 hypothetical protein 6303106 1215804 SAV_5198 Streptomyces avermitilis MA-4680 hypothetical protein NP_826375.1 6302630 R 227882 CDS NP_826376.1 29831742 1215805 complement(6303268..6303480) 1 NC_003155.4 PF04149: Domain of unknown function (DUF397); hypothetical protein 6303480 1215805 SAV_5199 Streptomyces avermitilis MA-4680 hypothetical protein NP_826376.1 6303268 R 227882 CDS NP_826377.1 29831743 1215806 complement(6303477..6304325) 1 NC_003155.4 DNA-binding protein 6304325 1215806 SAV_5200 Streptomyces avermitilis MA-4680 DNA-binding protein NP_826377.1 6303477 R 227882 CDS NP_826378.1 29831744 1215807 6304532..6305194 1 NC_003155.4 PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; hypothetical protein 6305194 1215807 SAV_5201 Streptomyces avermitilis MA-4680 hypothetical protein NP_826378.1 6304532 D 227882 CDS NP_826379.1 29831745 1215808 complement(6305198..6308119) 1 NC_003155.4 ATP-dependent helicase 6308119 1215808 SAV_5202 Streptomyces avermitilis MA-4680 ATP-dependent helicase NP_826379.1 6305198 R 227882 CDS NP_826380.1 29831746 1215809 6309050..6309583 1 NC_003155.4 hypothetical protein 6309583 1215809 SAV_5203 Streptomyces avermitilis MA-4680 hypothetical protein NP_826380.1 6309050 D 227882 CDS NP_826381.1 29831747 1215810 complement(6309631..6310644) 1 NC_003155.4 PF02810: SEC-C motif; hypothetical protein 6310644 1215810 SAV_5204 Streptomyces avermitilis MA-4680 hypothetical protein NP_826381.1 6309631 R 227882 CDS NP_826382.1 29831748 1215811 complement(6310847..6312322) 1 NC_003155.4 endo-beta-1,6-galactanase 6312322 1215811 SAV_5205 Streptomyces avermitilis MA-4680 endo-beta-1,6-galactanase NP_826382.1 6310847 R 227882 CDS NP_826383.1 29831749 1215812 6312601..6313419 1 NC_003155.4 PF04203: Sortase family; hypothetical protein 6313419 1215812 SAV_5206 Streptomyces avermitilis MA-4680 hypothetical protein NP_826383.1 6312601 D 227882 CDS NP_826384.1 29831750 1215813 6313586..6313921 1 NC_003155.4 hypothetical protein 6313921 1215813 SAV_5207 Streptomyces avermitilis MA-4680 hypothetical protein NP_826384.1 6313586 D 227882 CDS NP_826385.1 29831751 1215814 6314034..6314765 1 NC_003155.4 PF02096: 60Kd inner membrane protein; hypothetical protein 6314765 1215814 SAV_5208 Streptomyces avermitilis MA-4680 hypothetical protein NP_826385.1 6314034 D 227882 CDS NP_826386.1 29831752 1211224 6314908..6315765 1 NC_003155.4 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase 6315765 hpcE 1211224 hpcE Streptomyces avermitilis MA-4680 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase NP_826386.1 6314908 D 227882 CDS NP_826387.1 29831753 1215815 complement(6315925..6316416) 1 NC_003155.4 PF06142: Protein of unknown function (DUF967); hypothetical protein 6316416 1215815 SAV_5210 Streptomyces avermitilis MA-4680 hypothetical protein NP_826387.1 6315925 R 227882 CDS NP_826388.1 29831754 1215816 complement(6316485..6317579) 1 NC_003155.4 PF01408: Oxidoreductase family, NAD-binding Rossmann fold; oxidoreductase 6317579 1215816 SAV_5211 Streptomyces avermitilis MA-4680 oxidoreductase NP_826388.1 6316485 R 227882 CDS NP_826389.1 29831755 1215817 6317639..6318925 1 NC_003155.4 transcriptional regulator 6318925 1215817 SAV_5212 Streptomyces avermitilis MA-4680 transcriptional regulator NP_826389.1 6317639 D 227882 CDS NP_826390.1 29831756 1215818 6319187..6320206 1 NC_003155.4 hypothetical protein 6320206 1215818 SAV_5213 Streptomyces avermitilis MA-4680 hypothetical protein NP_826390.1 6319187 D 227882 CDS NP_826391.1 29831757 1215819 6320308..6321087 1 NC_003155.4 N-acetyl-glucosamine catabolism protein 6321087 1215819 SAV_5214 Streptomyces avermitilis MA-4680 N-acetyl-glucosamine catabolism protein NP_826391.1 6320308 D 227882 CDS NP_826392.1 29831758 1215820 6321293..6321940 1 NC_003155.4 hypothetical protein 6321940 1215820 SAV_5215 Streptomyces avermitilis MA-4680 hypothetical protein NP_826392.1 6321293 D 227882 CDS NP_826393.1 29831759 1215821 6322057..6322722 1 NC_003155.4 PF04203: Sortase family; hypothetical protein 6322722 1215821 SAV_5216 Streptomyces avermitilis MA-4680 hypothetical protein NP_826393.1 6322057 D 227882 CDS NP_826394.1 29831760 1215822 6323049..6324065 1 NC_003155.4 endo-1,4-beta-glucanase 6324065 1215822 SAV_5217 Streptomyces avermitilis MA-4680 endo-1,4-beta-glucanase NP_826394.1 6323049 D 227882 CDS NP_826395.1 29831761 1215823 complement(6324186..6326123) 1 NC_003155.4 PF07646: Kelch motif; protein 6326123 1215823 SAV_5218 Streptomyces avermitilis MA-4680 protein NP_826395.1 6324186 R 227882 CDS NP_826396.1 29831762 1215824 complement(6326120..6328114) 1 NC_003155.4 PF00535: Glycosyl transferase; glycosyl transferase 6328114 1215824 SAV_5219 Streptomyces avermitilis MA-4680 glycosyl transferase NP_826396.1 6326120 R 227882 CDS NP_826397.1 29831763 1215825 complement(6328439..6329161) 1 NC_003155.4 GntR family transcriptional regulator 6329161 1215825 SAV_5220 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_826397.1 6328439 R 227882 CDS NP_826398.1 29831764 1215826 6329508..6330707 1 NC_003155.4 PF00877: NlpC/P60 family; hypothetical protein 6330707 1215826 SAV_5221 Streptomyces avermitilis MA-4680 hypothetical protein NP_826398.1 6329508 D 227882 CDS NP_826399.1 29831765 1215827 6330754..6331950 1 NC_003155.4 PF01145: SPFH domain / Band 7 family; hypothetical protein 6331950 1215827 SAV_5222 Streptomyces avermitilis MA-4680 hypothetical protein NP_826399.1 6330754 D 227882 CDS NP_826400.1 29831766 1211226 6332060..6332716 1 NC_003155.4 chitin binding protein 6332716 chb 1211226 chb Streptomyces avermitilis MA-4680 chitin binding protein NP_826400.1 6332060 D 227882 CDS NP_826401.1 29831767 1215828 6332821..6333291 1 NC_003155.4 hypothetical protein 6333291 1215828 SAV_5224 Streptomyces avermitilis MA-4680 hypothetical protein NP_826401.1 6332821 D 227882 CDS NP_826402.1 29831768 1211227 6333369..6335009 1 NC_003155.4 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 6335009 fadD11 1211227 fadD11 Streptomyces avermitilis MA-4680 acyl-CoA synthetase NP_826402.1 6333369 D 227882 CDS NP_826403.1 29831769 1215829 complement(6335273..6336124) 1 NC_003155.4 IclR family transcriptional regulator 6336124 1215829 SAV_5226 Streptomyces avermitilis MA-4680 IclR family transcriptional regulator NP_826403.1 6335273 R 227882 CDS NP_826404.1 29831770 1215830 complement(6336208..6337023) 1 NC_003155.4 amino acid ABC transporter ATP-binding protein 6337023 1215830 SAV_5227 Streptomyces avermitilis MA-4680 amino acid ABC transporter ATP-binding protein NP_826404.1 6336208 R 227882 CDS NP_826405.1 29831771 1215831 complement(6337013..6337663) 1 NC_003155.4 amino acid ABC transporter permease 6337663 1215831 SAV_5228 Streptomyces avermitilis MA-4680 amino acid ABC transporter permease NP_826405.1 6337013 R 227882 CDS NP_826406.1 29831772 1215832 complement(6337660..6338409) 1 NC_003155.4 amino acid ABC transporter permease 6338409 1215832 SAV_5229 Streptomyces avermitilis MA-4680 amino acid ABC transporter permease NP_826406.1 6337660 R 227882 CDS NP_826407.1 29831773 1215833 complement(6338406..6339332) 1 NC_003155.4 ABC transporter substrate-binding protein 6339332 1215833 SAV_5230 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_826407.1 6338406 R 227882 CDS NP_826408.1 29831774 1215834 6339462..6339950 1 NC_003155.4 hypothetical protein 6339950 1215834 SAV_5231 Streptomyces avermitilis MA-4680 hypothetical protein NP_826408.1 6339462 D 227882 CDS NP_826409.1 29831775 1215835 complement(6339980..6341422) 1 NC_003155.4 putative amidase 6341422 1215835 SAV_5232 Streptomyces avermitilis MA-4680 putative amidase NP_826409.1 6339980 R 227882 CDS NP_826410.1 29831776 1215836 complement(6341451..6342410) 1 NC_003155.4 NAD-binding protein 6342410 1215836 SAV_5233 Streptomyces avermitilis MA-4680 NAD-binding protein NP_826410.1 6341451 R 227882 CDS NP_826411.1 29831777 1215837 6342585..6343388 1 NC_003155.4 PF01177: Asp/Glu/Hydantoin racemase; decarboxylase 6343388 1215837 SAV_5234 Streptomyces avermitilis MA-4680 decarboxylase NP_826411.1 6342585 D 227882 CDS NP_826412.1 29831778 1215838 6343385..6344119 1 NC_003155.4 PF01177: Asp/Glu/Hydantoin racemase; decarboxylase 6344119 1215838 SAV_5235 Streptomyces avermitilis MA-4680 decarboxylase NP_826412.1 6343385 D 227882 CDS NP_826413.1 29831779 1215839 6344263..6345414 1 NC_003155.4 PF00296: Luciferase-like monooxygenase; LuxAB-like protein (oxygenase) 6345414 1215839 SAV_5236 Streptomyces avermitilis MA-4680 LuxAB-like protein (oxygenase) NP_826413.1 6344263 D 227882 CDS NP_826414.1 29831780 1215840 complement(6345466..6347328) 1 NC_003155.4 PF00563: EAL domain; sensory box/GGDEF family protein 6347328 1215840 SAV_5237 Streptomyces avermitilis MA-4680 sensory box/GGDEF family protein NP_826414.1 6345466 R 227882 CDS NP_826415.1 29831781 1215841 6347684..6349207 1 NC_003155.4 hypothetical protein 6349207 1215841 SAV_5238 Streptomyces avermitilis MA-4680 hypothetical protein NP_826415.1 6347684 D 227882 CDS NP_826416.1 29831782 1215842 complement(6349376..6350023) 1 NC_003155.4 hypothetical protein 6350023 1215842 SAV_5239 Streptomyces avermitilis MA-4680 hypothetical protein NP_826416.1 6349376 R 227882 CDS NP_826417.1 29831783 1215843 complement(6350223..6350588) 1 NC_003155.4 hypothetical protein 6350588 1215843 SAV_5240 Streptomyces avermitilis MA-4680 hypothetical protein NP_826417.1 6350223 R 227882 CDS NP_826418.1 29831784 1215844 complement(6350999..6352318) 1 NC_003155.4 PF00270: DEAD/DEAH box helicase; hypothetical protein 6352318 1215844 SAV_5241 Streptomyces avermitilis MA-4680 hypothetical protein NP_826418.1 6350999 R 227882 CDS NP_826419.1 29831785 1215845 complement(6352315..6353910) 1 NC_003155.4 hypothetical protein 6353910 1215845 SAV_5242 Streptomyces avermitilis MA-4680 hypothetical protein NP_826419.1 6352315 R 227882 CDS NP_826420.1 29831786 1215846 complement(6353901..6354941) 1 NC_003155.4 protein 6354941 1215846 SAV_5243 Streptomyces avermitilis MA-4680 protein NP_826420.1 6353901 R 227882 CDS NP_826421.1 29831787 1215847 complement(6355048..6356004) 1 NC_003155.4 hypothetical protein 6356004 1215847 SAV_5244 Streptomyces avermitilis MA-4680 hypothetical protein NP_826421.1 6355048 R 227882 CDS NP_826422.1 29831788 1215848 6356198..6356815 1 NC_003155.4 mutase 6356815 1215848 SAV_5245 Streptomyces avermitilis MA-4680 mutase NP_826422.1 6356198 D 227882 CDS NP_826423.1 29831789 1215849 complement(6356869..6358461) 1 NC_003155.4 PF06036: Streptomyces protein of unknown function (DUF921); hypothetical protein 6358461 1215849 SAV_5246 Streptomyces avermitilis MA-4680 hypothetical protein NP_826423.1 6356869 R 227882 CDS NP_826424.1 29831790 1215850 6358763..6359197 1 NC_003155.4 hypothetical protein 6359197 1215850 SAV_5247 Streptomyces avermitilis MA-4680 hypothetical protein NP_826424.1 6358763 D 227882 CDS NP_826425.1 29831791 1215851 6359325..6360218 1 NC_003155.4 hypothetical protein 6360218 1215851 SAV_5248 Streptomyces avermitilis MA-4680 hypothetical protein NP_826425.1 6359325 D 227882 CDS NP_826426.1 29831792 1215852 complement(6360258..6360788) 1 NC_003155.4 protein 6360788 1215852 SAV_5249 Streptomyces avermitilis MA-4680 protein NP_826426.1 6360258 R 227882 CDS NP_826427.1 29831793 1215853 6360937..6361680 1 NC_003155.4 two-component system response regulator 6361680 1215853 SAV_5250 Streptomyces avermitilis MA-4680 two-component system response regulator NP_826427.1 6360937 D 227882 CDS NP_826428.1 29831794 1215854 6361677..6363050 1 NC_003155.4 two-component system sensor kinase 6363050 1215854 SAV_5251 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_826428.1 6361677 D 227882 CDS NP_826429.1 29831795 1215855 6363284..6364753 1 NC_003155.4 PF00553: Cellulose binding domain; sugar hydrolase 6364753 1215855 SAV_5252 Streptomyces avermitilis MA-4680 sugar hydrolase NP_826429.1 6363284 D 227882 CDS NP_826430.1 29831796 1215856 complement(6364894..6366342) 1 NC_003155.4 beta-glucosidase 6366342 bglC2 1215856 bglC2 Streptomyces avermitilis MA-4680 beta-glucosidase NP_826430.1 6364894 R 227882 CDS NP_826431.1 29831797 1215857 complement(6366512..6367435) 1 NC_003155.4 cellobiose ABC transporter permease 6367435 cebG 1215857 cebG Streptomyces avermitilis MA-4680 cellobiose ABC transporter permease NP_826431.1 6366512 R 227882 CDS NP_826432.1 29831798 1215858 complement(6367448..6368464) 1 NC_003155.4 cellobiose ABC transporter permease 6368464 cebF 1215858 cebF Streptomyces avermitilis MA-4680 cellobiose ABC transporter permease NP_826432.1 6367448 R 227882 CDS NP_826433.1 29831799 1215859 complement(6368470..6369831) 1 NC_003155.4 cellobiose ABC transporter substrate-binding protein 6369831 cebE 1215859 cebE Streptomyces avermitilis MA-4680 cellobiose ABC transporter substrate-binding protein NP_826433.1 6368470 R 227882 CDS NP_826434.1 29831800 1215860 6370230..6371285 1 NC_003155.4 LacI family transcriptional regulator 6371285 1215860 SAV_5257 Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_826434.1 6370230 D 227882 CDS NP_826435.1 29831801 1215861 complement(6371369..6371977) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; hypothetical protein 6371977 1215861 SAV_5258 Streptomyces avermitilis MA-4680 hypothetical protein NP_826435.1 6371369 R 227882 CDS NP_826436.1 29831802 1215862 complement(6372118..6372600) 1 NC_003155.4 hypothetical protein 6372600 1215862 SAV_5259 Streptomyces avermitilis MA-4680 hypothetical protein NP_826436.1 6372118 R 227882 CDS NP_826437.1 29831803 1211231 complement(6372895..6373497) 1 NC_003155.4 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 6373497 orn 1211231 orn Streptomyces avermitilis MA-4680 oligoribonuclease NP_826437.1 6372895 R 227882 CDS NP_826438.1 29831804 1215863 complement(6373649..6374929) 1 NC_003155.4 AraC family transcription regulator 6374929 1215863 SAV_5261 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_826438.1 6373649 R 227882 CDS NP_826439.1 29831805 1215864 complement(6375308..6375745) 1 NC_003155.4 PF07172: Glycine rich protein family; hypothetical protein 6375745 1215864 SAV_5262 Streptomyces avermitilis MA-4680 hypothetical protein NP_826439.1 6375308 R 227882 CDS NP_826440.1 29831806 1215865 6376089..6376616 1 NC_003155.4 PF00582: Universal stress protein family; hypothetical protein 6376616 1215865 SAV_5263 Streptomyces avermitilis MA-4680 hypothetical protein NP_826440.1 6376089 D 227882 CDS NP_826441.1 29831807 1215866 6376767..6377333 1 NC_003155.4 PF01184: GPR1/FUN34/yaaH family; hypothetical protein 6377333 1215866 SAV_5264 Streptomyces avermitilis MA-4680 hypothetical protein NP_826441.1 6376767 D 227882 CDS NP_826442.1 29831808 1211232 complement(6377438..6379255) 1 NC_003155.4 L-glutamine-D-fructose-6-phosphate amidotransferase 6379255 glmS2 1211232 glmS2 Streptomyces avermitilis MA-4680 L-glutamine-D-fructose-6-phosphate amidotransferase NP_826442.1 6377438 R 227882 CDS NP_826443.1 29831809 1215867 complement(6379293..6379550) 1 NC_003155.4 hypothetical protein 6379550 1215867 SAV_5266 Streptomyces avermitilis MA-4680 hypothetical protein NP_826443.1 6379293 R 227882 CDS NP_826444.1 29831810 1211233 6379752..6381278 1 NC_003155.4 phosphoesterase 6381278 ppe2 1211233 ppe2 Streptomyces avermitilis MA-4680 phosphoesterase NP_826444.1 6379752 D 227882 CDS NP_826445.1 29831811 1211234 6381542..6383131 1 NC_003155.4 beta-N-acetylhexosaminidase 6383131 nagZ4 1211234 nagZ4 Streptomyces avermitilis MA-4680 beta-N-acetylhexosaminidase NP_826445.1 6381542 D 227882 CDS NP_826446.1 29831812 1211235 complement(6383181..6384953) 1 NC_003155.4 alcC, siderophore biosynthesis, PF04183: IucA / IucC family; siderophore biosynthetic enzyme 6384953 sidA 1211235 sidA Streptomyces avermitilis MA-4680 siderophore biosynthetic enzyme NP_826446.1 6383181 R 227882 CDS NP_826447.1 29831813 1211236 complement(6384950..6385501) 1 NC_003155.4 alcB, siderophore biosynthesis, PF00583: Acetyltransferase (GNAT) family; aceytltranferase 6385501 sidB 1211236 sidB Streptomyces avermitilis MA-4680 aceytltranferase NP_826447.1 6384950 R 227882 CDS NP_826448.1 29831814 1211237 complement(6385498..6386769) 1 NC_003155.4 alcA, siderophore biosynthesis; monooxigenase 6386769 sidC 1211237 sidC Streptomyces avermitilis MA-4680 monooxigenase NP_826448.1 6385498 R 227882 CDS NP_826449.1 29831815 1211238 complement(6386774..6388291) 1 NC_003155.4 rhbB, siderophore biosynthesis, PF00282: Pyridoxal-dependent decarboxylase conserved domain; L-2,4-diaminobutyrate decarboxylase 6388291 sidD 1211238 sidD Streptomyces avermitilis MA-4680 L-2,4-diaminobutyrate decarboxylase NP_826449.1 6386774 R 227882 CDS NP_826450.1 29831816 1215868 complement(6388354..6389226) 1 NC_003155.4 siderophore biosynthesis, PF04954: Siderophore-interacting protein; siderophore-interacting protein 6389226 sidE 1215868 sidE Streptomyces avermitilis MA-4680 siderophore-interacting protein NP_826450.1 6388354 R 227882 CDS NP_826451.1 29831817 1215869 complement(6389302..6390351) 1 NC_003155.4 siderophore biosynthesis; ferrichrome ABC transporter substrate-binding protein 6390351 sidF 1215869 sidF Streptomyces avermitilis MA-4680 ferrichrome ABC transporter substrate-binding protein NP_826451.1 6389302 R 227882 CDS NP_826452.1 29831818 1211239 complement(6390485..6391645) 1 NC_003155.4 acdH, PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 6391645 fadE4 1211239 fadE4 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_826452.1 6390485 R 227882 CDS NP_826453.1 29831819 1211240 complement(6391651..6392598) 1 NC_003155.4 hydroxymethylglutaryl-CoA lyase 6392598 hmgL 1211240 hmgL Streptomyces avermitilis MA-4680 hydroxymethylglutaryl-CoA lyase NP_826453.1 6391651 R 227882 CDS NP_826454.1 29831820 1211241 complement(6392595..6394697) 1 NC_003155.4 acetyl/propionyl CoA carboxylase alpha subunit 6394697 accA1 1211241 accA1 Streptomyces avermitilis MA-4680 acetyl/propionyl CoA carboxylase alpha subunit NP_826454.1 6392595 R 227882 CDS NP_826455.1 29831821 1211242 complement(6394706..6396337) 1 NC_003155.4 acetyl/propionyl CoA carboxylase, beta subunit 6396337 accD1 1211242 accD1 Streptomyces avermitilis MA-4680 acetyl/propionyl CoA carboxylase, beta subunit NP_826455.1 6394706 R 227882 CDS NP_826456.1 29831822 1215870 6396435..6397025 1 NC_003155.4 TetR family transcriptional regulator 6397025 1215870 SAV_5279 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_826456.1 6396435 D 227882 CDS NP_826457.1 29831823 1211243 6397123..6398280 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 6398280 fadE7 1211243 fadE7 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_826457.1 6397123 D 227882 CDS NP_826458.1 29831824 1211244 6398315..6399187 1 NC_003155.4 PF02551: Acyl-CoA thioesterase; acyl-CoA thioesterase 6399187 tesB2 1211244 tesB2 Streptomyces avermitilis MA-4680 acyl-CoA thioesterase NP_826458.1 6398315 D 227882 CDS NP_826459.1 29831825 1215871 complement(6399273..6400061) 1 NC_003155.4 hypothetical protein 6400061 1215871 SAV_5282 Streptomyces avermitilis MA-4680 hypothetical protein NP_826459.1 6399273 R 227882 CDS NP_826460.1 29831826 1215872 complement(6400144..6401757) 1 NC_003155.4 regulatory protein 6401757 1215872 SAV_5283 Streptomyces avermitilis MA-4680 regulatory protein NP_826460.1 6400144 R 227882 CDS NP_826461.1 29831827 1215873 6401945..6403405 1 NC_003155.4 PF00474: Sodium:solute symporter family; sodium:solute symporter 6403405 1215873 SAV_5284 Streptomyces avermitilis MA-4680 sodium:solute symporter NP_826461.1 6401945 D 227882 CDS NP_826462.1 29831828 1211245 6403444..6404412 1 NC_003155.4 agmatinase 6404412 speB 1211245 speB Streptomyces avermitilis MA-4680 agmatinase NP_826462.1 6403444 D 227882 CDS NP_826463.1 29831829 1211246 6404409..6406094 1 NC_003155.4 acetolactate synthase 6406094 ilvB4 1211246 ilvB4 Streptomyces avermitilis MA-4680 acetolactate synthase NP_826463.1 6404409 D 227882 CDS NP_826464.1 29831830 1215874 complement(6406163..6407590) 1 NC_003155.4 PF01839: FG-GAP repeat; hypothetical protein 6407590 1215874 SAV_5287 Streptomyces avermitilis MA-4680 hypothetical protein NP_826464.1 6406163 R 227882 CDS NP_826465.1 29831831 1215875 complement(6407814..6408467) 1 NC_003155.4 hypothetical protein 6408467 1215875 SAV_5288 Streptomyces avermitilis MA-4680 hypothetical protein NP_826465.1 6407814 R 227882 CDS NP_826466.1 29831832 1215876 complement(6408531..6409337) 1 NC_003155.4 PF04231: Endonuclease I; ribonuclease 6409337 1215876 SAV_5289 Streptomyces avermitilis MA-4680 ribonuclease NP_826466.1 6408531 R 227882 CDS NP_826467.1 29831833 1215877 complement(6409562..6411889) 1 NC_003155.4 PF02366: Dolichyl-phosphate-mannose-protein mannosyltransferase; integral membrane protein 6411889 1215877 SAV_5290 Streptomyces avermitilis MA-4680 integral membrane protein NP_826467.1 6409562 R 227882 CDS NP_826468.1 29831834 1215878 6412403..6412882 1 NC_003155.4 hypothetical protein 6412882 1215878 SAV_5291 Streptomyces avermitilis MA-4680 hypothetical protein NP_826468.1 6412403 D 227882 CDS NP_826469.1 29831835 1215879 6413260..6415170 1 NC_003155.4 PF01079: Hint module; hypothetical protein 6415170 1215879 SAV_5292 Streptomyces avermitilis MA-4680 hypothetical protein NP_826469.1 6413260 D 227882 CDS NP_826470.1 29831836 1215880 6415575..6416147 1 NC_003155.4 hypothetical protein 6416147 1215880 SAV_5293 Streptomyces avermitilis MA-4680 hypothetical protein NP_826470.1 6415575 D 227882 CDS NP_826471.1 29831837 1215881 complement(6416192..6416413) 1 NC_003155.4 regulatory protein 6416413 1215881 SAV_5294 Streptomyces avermitilis MA-4680 regulatory protein NP_826471.1 6416192 R 227882 CDS NP_826472.1 29831838 1215882 complement(6416406..6417206) 1 NC_003155.4 DNA-binding protein 6417206 1215882 SAV_5295 Streptomyces avermitilis MA-4680 DNA-binding protein NP_826472.1 6416406 R 227882 CDS NP_826473.1 29831839 1215883 6417274..6417711 1 NC_003155.4 hypothetical protein 6417711 1215883 SAV_5296 Streptomyces avermitilis MA-4680 hypothetical protein NP_826473.1 6417274 D 227882 CDS NP_826474.1 29831840 1215884 6417708..6418046 1 NC_003155.4 hypothetical protein 6418046 1215884 SAV_5297 Streptomyces avermitilis MA-4680 hypothetical protein NP_826474.1 6417708 D 227882 CDS NP_826475.1 29831841 1215885 6418264..6419196 1 NC_003155.4 protein 6419196 1215885 SAV_5298 Streptomyces avermitilis MA-4680 protein NP_826475.1 6418264 D 227882 CDS NP_826476.1 29831842 1215886 6419461..6423234 1 NC_003155.4 ABC transporter ATP-binding protein 6423234 1215886 SAV_5299 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_826476.1 6419461 D 227882 CDS NP_826477.1 29831843 1215887 6423971..6425419 1 NC_003155.4 PF05576: PS-10 peptidase S37; tripeptidyl aminopeptidase 6425419 1215887 SAV_5300 Streptomyces avermitilis MA-4680 tripeptidyl aminopeptidase NP_826477.1 6423971 D 227882 CDS NP_826478.1 29831844 1215888 complement(6425826..6426458) 1 NC_003155.4 hypothetical protein 6426458 1215888 SAV_5301 Streptomyces avermitilis MA-4680 hypothetical protein NP_826478.1 6425826 R 227882 CDS NP_826479.1 29831845 1211247 complement(6426573..6428423) 1 NC_003155.4 beta-N-acetylhexosaminidase 6428423 nagZ5 1211247 nagZ5 Streptomyces avermitilis MA-4680 beta-N-acetylhexosaminidase NP_826479.1 6426573 R 227882 CDS NP_826480.1 29831846 1215889 complement(6428842..6429768) 1 NC_003155.4 LysR family transcriptional regulator 6429768 1215889 SAV_5303 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_826480.1 6428842 R 227882 CDS NP_826481.1 29831847 1215890 6429856..6430776 1 NC_003155.4 PF00892: Integral membrane protein DUF6; hypothetical protein 6430776 1215890 SAV_5304 Streptomyces avermitilis MA-4680 hypothetical protein NP_826481.1 6429856 D 227882 CDS NP_826482.1 29831848 1215891 6430773..6431282 1 NC_003155.4 hypothetical protein 6431282 1215891 SAV_5305 Streptomyces avermitilis MA-4680 hypothetical protein NP_826482.1 6430773 D 227882 CDS NP_826483.1 29831849 1215892 complement(6431284..6433035) 1 NC_003155.4 hypothetical protein 6433035 1215892 SAV_5306 Streptomyces avermitilis MA-4680 hypothetical protein NP_826483.1 6431284 R 227882 CDS NP_826484.1 29831850 1215893 complement(6433101..6434729) 1 NC_003155.4 PF05419: GUN4-like; hypothetical protein 6434729 1215893 SAV_5307 Streptomyces avermitilis MA-4680 hypothetical protein NP_826484.1 6433101 R 227882 CDS NP_826485.1 29831851 1211248 complement(6434726..6435712) 1 NC_003155.4 serine/threonine protein kinase 6435712 pkn25 1211248 pkn25 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_826485.1 6434726 R 227882 CDS NP_826486.1 29831852 1215894 complement(6435765..6436322) 1 NC_003155.4 hypothetical protein 6436322 1215894 SAV_5309 Streptomyces avermitilis MA-4680 hypothetical protein NP_826486.1 6435765 R 227882 CDS NP_826487.1 29831853 1215895 complement(6436457..6437257) 1 NC_003155.4 PF01261: AP endonuclease family 2; hypothetical protein 6437257 1215895 SAV_5310 Streptomyces avermitilis MA-4680 hypothetical protein NP_826487.1 6436457 R 227882 CDS NP_826488.1 29831854 1215896 complement(6437291..6438223) 1 NC_003155.4 MarR family transcriptional regulator 6438223 1215896 SAV_5311 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_826488.1 6437291 R 227882 CDS NP_826489.1 29831855 1215897 complement(6438512..6439552) 1 NC_003155.4 LacI family transcriptional regulator 6439552 1215897 SAV_5312 Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_826489.1 6438512 R 227882 CDS NP_826490.1 29831856 1215898 6439787..6440938 1 NC_003155.4 PF01408: Oxidoreductase family, NAD-binding Rossmann fold; oxidoreductase 6440938 1215898 SAV_5313 Streptomyces avermitilis MA-4680 oxidoreductase NP_826490.1 6439787 D 227882 CDS NP_826491.1 29831857 1215899 6440935..6442086 1 NC_003155.4 PF06187: Protein of unknown function (DUF993); hypothetical protein 6442086 1215899 SAV_5314 Streptomyces avermitilis MA-4680 hypothetical protein NP_826491.1 6440935 D 227882 CDS NP_826492.1 29831858 1215900 6442083..6442916 1 NC_003155.4 PF01261: AP endonuclease family 2; hypothetical protein 6442916 1215900 SAV_5315 Streptomyces avermitilis MA-4680 hypothetical protein NP_826492.1 6442083 D 227882 CDS NP_826493.1 29831859 1211249 complement(6443152..6443541) 1 NC_003155.4 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 6443541 rbsD 1211249 rbsD Streptomyces avermitilis MA-4680 D-ribose pyranase NP_826493.1 6443152 R 227882 CDS NP_826494.1 29831860 1211250 complement(6443538..6444437) 1 NC_003155.4 PF00294: pfkB family carbohydrate kinase; ribokinase 6444437 rbsK 1211250 rbsK Streptomyces avermitilis MA-4680 ribokinase NP_826494.1 6443538 R 227882 CDS NP_826495.1 29831861 1211251 complement(6444518..6446464) 1 NC_003155.4 D-ribose transport system; D-ribose ABC transporter permease 6446464 rbsC 1211251 rbsC Streptomyces avermitilis MA-4680 D-ribose ABC transporter permease NP_826495.1 6444518 R 227882 CDS NP_826496.1 29831862 1211252 complement(6446454..6448022) 1 NC_003155.4 D-ribose transport system; D-ribose ABC transporter ATP-binding protein 6448022 rbsA 1211252 rbsA Streptomyces avermitilis MA-4680 D-ribose ABC transporter ATP-binding protein NP_826496.1 6446454 R 227882 CDS NP_826497.1 29831863 1211253 complement(6448019..6449083) 1 NC_003155.4 transcriptional regulator mediating carbon catabolite repression; LacI family transcriptional regulator 6449083 rbsR 1211253 rbsR Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_826497.1 6448019 R 227882 CDS NP_826498.1 29831864 1215901 6449441..6449773 1 NC_003155.4 hypothetical protein 6449773 1215901 SAV_5321 Streptomyces avermitilis MA-4680 hypothetical protein NP_826498.1 6449441 D 227882 CDS NP_826499.1 29831865 1215902 6449871..6450188 1 NC_003155.4 hypothetical protein 6450188 1215902 SAV_5322 Streptomyces avermitilis MA-4680 hypothetical protein NP_826499.1 6449871 D 227882 CDS NP_826500.1 29831866 1215903 6450229..6450627 1 NC_003155.4 hypothetical protein 6450627 1215903 SAV_5323 Streptomyces avermitilis MA-4680 hypothetical protein NP_826500.1 6450229 D 227882 CDS NP_826501.1 29831867 1215904 6450624..6453326 1 NC_003155.4 hypothetical protein 6453326 1215904 SAV_5324 Streptomyces avermitilis MA-4680 hypothetical protein NP_826501.1 6450624 D 227882 CDS NP_826502.1 29831868 1215905 6453323..6454330 1 NC_003155.4 hypothetical protein 6454330 1215905 SAV_5325 Streptomyces avermitilis MA-4680 hypothetical protein NP_826502.1 6453323 D 227882 CDS NP_826503.1 29831869 1215906 6454562..6454924 1 NC_003155.4 hypothetical protein 6454924 1215906 SAV_5326 Streptomyces avermitilis MA-4680 hypothetical protein NP_826503.1 6454562 D 227882 CDS NP_826504.1 29831870 1215907 6454903..6455595 1 NC_003155.4 hypothetical protein 6455595 1215907 SAV_5327 Streptomyces avermitilis MA-4680 hypothetical protein NP_826504.1 6454903 D 227882 CDS NP_826505.1 29831871 1215908 6455728..6456090 1 NC_003155.4 hypothetical protein 6456090 1215908 SAV_5328 Streptomyces avermitilis MA-4680 hypothetical protein NP_826505.1 6455728 D 227882 CDS NP_826506.1 29831872 1211254 6456160..6458436 1 NC_003155.4 PF05127: Putative ATPase (DUF699); exodeoxyribonuclease V 6458436 recD 1211254 recD Streptomyces avermitilis MA-4680 exodeoxyribonuclease V NP_826506.1 6456160 D 227882 CDS NP_826507.1 29831873 1211255 6458679..6459968 1 NC_003155.4 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 6459968 gltA 1211255 gltA Streptomyces avermitilis MA-4680 type II citrate synthase NP_826507.1 6458679 D 227882 CDS NP_826508.1 29831874 1211256 complement(6460625..6462877) 1 NC_003155.4 PF00122: E1-E2 ATPase; cation-transporting P-type ATPase 6462877 ctpA 1211256 ctpA Streptomyces avermitilis MA-4680 cation-transporting P-type ATPase NP_826508.1 6460625 R 227882 CDS NP_826509.1 29831875 1215909 complement(6462983..6463222) 1 NC_003155.4 copper chaperone 6463222 1215909 SAV_5332 Streptomyces avermitilis MA-4680 copper chaperone NP_826509.1 6462983 R 227882 CDS NP_826510.1 29831876 1215910 complement(6463533..6464231) 1 NC_003155.4 TetR family transcriptional regulator 6464231 1215910 SAV_5333 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_826510.1 6463533 R 227882 CDS NP_826511.1 29831877 1215911 6464399..6466717 1 NC_003155.4 PF03176: MMPL family; hypothetical protein 6466717 1215911 SAV_5334 Streptomyces avermitilis MA-4680 hypothetical protein NP_826511.1 6464399 D 227882 CDS NP_826512.1 29831878 1215912 6466793..6467836 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; oxidoreductase 6467836 1215912 SAV_5335 Streptomyces avermitilis MA-4680 oxidoreductase NP_826512.1 6466793 D 227882 CDS NP_826513.1 29831879 1215913 complement(6467912..6468190) 1 NC_003155.4 MarR family transcriptional regulator 6468190 1215913 SAV_5336 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_826513.1 6467912 R 227882 CDS NP_826514.1 29831880 1215914 complement(6468756..6469664) 1 NC_003155.4 inositol metaqbolism, PF06960: Myo-inositol catabolism protein N-terminus; IolE protein 6469664 iolE1 1215914 iolE1 Streptomyces avermitilis MA-4680 IolE protein NP_826514.1 6468756 R 227882 CDS NP_826515.1 29831881 1215915 6469797..6470747 1 NC_003155.4 inositol metabolism, PF00294: pfkB family carbohydrate kinase; IolC protein 6470747 iolC1 1215915 iolC1 Streptomyces avermitilis MA-4680 IolC protein NP_826515.1 6469797 D 227882 CDS NP_826516.1 29831882 1215916 6470744..6471778 1 NC_003155.4 PF04274: Tagatose 1,6-diphosphate aldolase, (LacD); hypothetical protein 6471778 1215916 SAV_5339 Streptomyces avermitilis MA-4680 hypothetical protein NP_826516.1 6470744 D 227882 CDS NP_826517.1 29831883 1211257 6471786..6472607 1 NC_003155.4 inositol metabolism, PF06845: Myo-inositol catabolism protein IolB; IolB protein 6472607 iolB1 1211257 iolB1 Streptomyces avermitilis MA-4680 IolB protein NP_826517.1 6471786 D 227882 CDS NP_826518.1 29831884 1211258 6472604..6474487 1 NC_003155.4 inositol metabolism, PF00205: Thiamine pyrophosphate enzyme, central domain; IolD protein 6474487 iolD1 1211258 iolD1 Streptomyces avermitilis MA-4680 IolD protein NP_826518.1 6472604 D 227882 CDS NP_826519.1 29831885 1211259 6474502..6476004 1 NC_003155.4 methylmalonic acid semialdehyde dehydrogenase 6476004 iolA 1211259 iolA Streptomyces avermitilis MA-4680 methylmalonic acid semialdehyde dehydrogenase NP_826519.1 6474502 D 227882 CDS NP_826520.1 29831886 1215917 6476304..6477713 1 NC_003155.4 PF00324: Amino acid permease; amino acid transporter 6477713 1215917 SAV_5343 Streptomyces avermitilis MA-4680 amino acid transporter NP_826520.1 6476304 D 227882 CDS NP_826521.1 29831887 1215918 6477929..6480523 1 NC_003155.4 ABC transporter ATP-binding protein 6480523 1215918 SAV_5344 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_826521.1 6477929 D 227882 CDS NP_826522.1 29831888 1215919 6480520..6481383 1 NC_003155.4 ABC transporter permease 6481383 1215919 SAV_5345 Streptomyces avermitilis MA-4680 ABC transporter permease NP_826522.1 6480520 D 227882 CDS NP_826523.1 29831889 1215920 6481983..6482243 1 NC_003155.4 hypothetical protein 6482243 1215920 SAV_5346 Streptomyces avermitilis MA-4680 hypothetical protein NP_826523.1 6481983 D 227882 CDS NP_826524.1 29831890 1215921 6482542..6482802 1 NC_003155.4 hypothetical protein 6482802 1215921 SAV_5347 Streptomyces avermitilis MA-4680 hypothetical protein NP_826524.1 6482542 D 227882 CDS NP_826525.1 29831891 1215922 6483136..6483474 1 NC_003155.4 hypothetical protein 6483474 1215922 SAV_5348 Streptomyces avermitilis MA-4680 hypothetical protein NP_826525.1 6483136 D 227882 CDS NP_826526.1 29831892 1215923 6483734..6484015 1 NC_003155.4 hypothetical protein 6484015 1215923 SAV_5349 Streptomyces avermitilis MA-4680 hypothetical protein NP_826526.1 6483734 D 227882 CDS NP_826527.1 29831893 1215924 6485437..6487158 1 NC_003155.4 hypothetical protein 6487158 1215924 SAV_5350 Streptomyces avermitilis MA-4680 hypothetical protein NP_826527.1 6485437 D 227882 CDS NP_826528.1 29831894 1215925 6487510..6488730 1 NC_003155.4 PF00746: Gram positive anchor; protein 6488730 1215925 SAV_5351 Streptomyces avermitilis MA-4680 protein NP_826528.1 6487510 D 227882 CDS NP_826529.1 29831895 1215926 complement(6488769..6489893) 1 NC_003155.4 hypothetical protein 6489893 1215926 SAV_5352 Streptomyces avermitilis MA-4680 hypothetical protein NP_826529.1 6488769 R 227882 CDS NP_826530.1 29831896 1215927 complement(6489890..6490564) 1 NC_003155.4 PF02706: Chain length determinant protein; hypothetical protein 6490564 1215927 SAV_5353 Streptomyces avermitilis MA-4680 hypothetical protein NP_826530.1 6489890 R 227882 CDS NP_826531.1 29831897 1215928 complement(6490564..6491739) 1 NC_003155.4 PF00534: Glycosyl transferases group 1; glycosyl transferase 6491739 1215928 SAV_5354 Streptomyces avermitilis MA-4680 glycosyl transferase NP_826531.1 6490564 R 227882 CDS NP_826532.1 29831898 1215929 complement(6491750..6492448) 1 NC_003155.4 PF01522: Polysaccharide deacetylase; polysaccharide deacetylase 6492448 1215929 SAV_5355 Streptomyces avermitilis MA-4680 polysaccharide deacetylase NP_826532.1 6491750 R 227882 CDS NP_826533.1 29831899 1215930 complement(6492519..6494279) 1 NC_003155.4 PF03023: MviN-like protein; hypothetical protein 6494279 1215930 SAV_5356 Streptomyces avermitilis MA-4680 hypothetical protein NP_826533.1 6492519 R 227882 CDS NP_826534.1 29831900 1215931 complement(6494276..6495631) 1 NC_003155.4 PF04932: O-Antigen Polymerase; hypothetical protein 6495631 1215931 SAV_5357 Streptomyces avermitilis MA-4680 hypothetical protein NP_826534.1 6494276 R 227882 CDS NP_826535.1 29831901 1215932 complement(6495638..6497113) 1 NC_003155.4 PF02397: Bacterial sugar transferase; sugar transferase 6497113 1215932 SAV_5358 Streptomyces avermitilis MA-4680 sugar transferase NP_826535.1 6495638 R 227882 CDS NP_826536.1 29831902 1215933 complement(6497110..6498351) 1 NC_003155.4 PF00534: Glycosyl transferases group 1; glycosyl transferase 6498351 1215933 SAV_5359 Streptomyces avermitilis MA-4680 glycosyl transferase NP_826536.1 6497110 R 227882 CDS NP_826537.1 29831903 1215934 6499049..6499312 1 NC_003155.4 protein 6499312 1215934 SAV_5360 Streptomyces avermitilis MA-4680 protein NP_826537.1 6499049 D 227882 CDS NP_826538.1 29831904 1211260 6500109..6500495 1 NC_003155.4 second mel operon; tyrosinase co-factor protein 6500495 melC2-2 1211260 melC2-2 Streptomyces avermitilis MA-4680 tyrosinase co-factor protein NP_826538.1 6500109 D 227882 CDS NP_826539.1 29831905 1211261 6500482..6501345 1 NC_003155.4 second mel operon, not form melanin; tyrosinase 6501345 melC1-2 1211261 melC1-2 Streptomyces avermitilis MA-4680 tyrosinase NP_826539.1 6500482 D 227882 CDS NP_826540.1 29831906 1215935 6501856..6503502 1 NC_003155.4 ATP-binding protein 6503502 1215935 SAV_5363 Streptomyces avermitilis MA-4680 ATP-binding protein NP_826540.1 6501856 D 227882 CDS NP_826541.1 29831907 1215936 6503805..6505673 1 NC_003155.4 ATP-binding protein 6505673 1215936 SAV_5364 Streptomyces avermitilis MA-4680 ATP-binding protein NP_826541.1 6503805 D 227882 CDS NP_826542.1 29831908 1215937 6505871..6506347 1 NC_003155.4 single-strand DNA-binding protein 6506347 1215937 SAV_5365 Streptomyces avermitilis MA-4680 single-strand DNA-binding protein NP_826542.1 6505871 D 227882 CDS NP_826543.1 29831909 1215938 6506611..6508026 1 NC_003155.4 PF05506: Domain of unknown function (DUF756); hypothetical protein 6508026 1215938 SAV_5366 Streptomyces avermitilis MA-4680 hypothetical protein NP_826543.1 6506611 D 227882 CDS NP_826544.1 29831910 1215939 6508321..6509964 1 NC_003155.4 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; putative ABC transporter ATP-binding protein 6509964 1215939 SAV_5367 Streptomyces avermitilis MA-4680 putative ABC transporter ATP-binding protein NP_826544.1 6508321 D 227882 CDS NP_826545.1 29831911 1215940 6509967..6510377 1 NC_003155.4 PF03061: Thioesterase superfamily; hypothetical protein 6510377 1215940 SAV_5368 Streptomyces avermitilis MA-4680 hypothetical protein NP_826545.1 6509967 D 227882 CDS NP_826546.1 29831912 1215941 6510374..6511069 1 NC_003155.4 hypothetical protein 6511069 1215941 SAV_5369 Streptomyces avermitilis MA-4680 hypothetical protein NP_826546.1 6510374 D 227882 CDS NP_826547.1 29831913 1215942 complement(6511098..6511502) 1 NC_003155.4 PF01152: Bacterial-like globin; globin-like protein 6511502 glbO 1215942 glbO Streptomyces avermitilis MA-4680 globin-like protein NP_826547.1 6511098 R 227882 CDS NP_826548.1 29831914 1215943 6511654..6512634 1 NC_003155.4 O-methyltransferase 6512634 1215943 SAV_5371 Streptomyces avermitilis MA-4680 O-methyltransferase NP_826548.1 6511654 D 227882 CDS NP_826549.1 29831915 1215944 complement(6512668..6514113) 1 NC_003155.4 PF00498: FHA domain; hypothetical protein 6514113 1215944 SAV_5372 Streptomyces avermitilis MA-4680 hypothetical protein NP_826549.1 6512668 R 227882 CDS NP_826550.1 29831916 1215945 complement(6514219..6515595) 1 NC_003155.4 PF00092: von Willebrand factor type A domain; hypothetical protein 6515595 1215945 SAV_5373 Streptomyces avermitilis MA-4680 hypothetical protein NP_826550.1 6514219 R 227882 CDS NP_826551.1 29831917 1215946 complement(6515722..6517065) 1 NC_003155.4 PF00481: Protein phosphatase 2C; magnesium or manganese-dependent protein phosphatase 6517065 prpB10 1215946 prpB10 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_826551.1 6515722 R 227882 CDS NP_826552.1 29831918 1211263 complement(6517066..6519570) 1 NC_003155.4 serine/threonine protein kinase 6519570 pkn26 1211263 pkn26 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_826552.1 6517066 R 227882 CDS NP_826553.1 29831919 1215947 complement(6519590..6520915) 1 NC_003155.4 hypothetical protein 6520915 1215947 SAV_5376 Streptomyces avermitilis MA-4680 hypothetical protein NP_826553.1 6519590 R 227882 CDS NP_826554.1 29831920 1215948 complement(6521003..6522010) 1 NC_003155.4 amino acid ABC transporter substrate-binding protein 6522010 1215948 SAV_5377 Streptomyces avermitilis MA-4680 amino acid ABC transporter substrate-binding protein NP_826554.1 6521003 R 227882 CDS NP_826555.1 29831921 1215949 complement(6522025..6523488) 1 NC_003155.4 protein 6523488 1215949 SAV_5378 Streptomyces avermitilis MA-4680 protein NP_826555.1 6522025 R 227882 CDS NP_826556.1 29831922 1215950 complement(6523797..6524753) 1 NC_003155.4 kinase 6524753 1215950 SAV_5379 Streptomyces avermitilis MA-4680 kinase NP_826556.1 6523797 R 227882 CDS NP_826557.1 29831923 1215951 complement(6524786..6526051) 1 NC_003155.4 6-phospho-beta-glucosidase 6526051 bglA2 1215951 bglA2 Streptomyces avermitilis MA-4680 6-phospho-beta-glucosidase NP_826557.1 6524786 R 227882 CDS NP_826558.1 29831924 1215952 complement(6526055..6526948) 1 NC_003155.4 sugar ABC transporter permease 6526948 1215952 SAV_5381 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_826558.1 6526055 R 227882 CDS NP_826559.1 29831925 1215953 complement(6526951..6527892) 1 NC_003155.4 sugar ABC transporter permease 6527892 1215953 SAV_5382 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_826559.1 6526951 R 227882 CDS NP_826560.1 29831926 1215954 complement(6527895..6529232) 1 NC_003155.4 sugar ABC transporter substrate-binding protein 6529232 1215954 SAV_5383 Streptomyces avermitilis MA-4680 sugar ABC transporter substrate-binding protein NP_826560.1 6527895 R 227882 CDS NP_826561.1 29831927 1215955 complement(6529378..6530589) 1 NC_003155.4 transcriptional regulator 6530589 1215955 SAV_5384 Streptomyces avermitilis MA-4680 transcriptional regulator NP_826561.1 6529378 R 227882 CDS NP_826562.1 29831928 1215956 complement(6531060..6532160) 1 NC_003155.4 PF00924: Mechanosensitive ion channel; hypothetical protein 6532160 1215956 SAV_5385 Streptomyces avermitilis MA-4680 hypothetical protein NP_826562.1 6531060 R 227882 CDS NP_826563.1 29831929 1215957 6532474..6533010 1 NC_003155.4 endonuclease 6533010 1215957 SAV_5386 Streptomyces avermitilis MA-4680 endonuclease NP_826563.1 6532474 D 227882 CDS NP_826564.1 29831930 1215958 complement(6533165..6534508) 1 NC_003155.4 PF02687: Predicted permease; hypothetical protein 6534508 1215958 SAV_5387 Streptomyces avermitilis MA-4680 hypothetical protein NP_826564.1 6533165 R 227882 CDS NP_826565.1 29831931 1215959 complement(6534505..6535218) 1 NC_003155.4 ABC transporter ATP-binding protein 6535218 1215959 SAV_5388 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_826565.1 6534505 R 227882 CDS NP_826566.1 29831932 1215960 complement(6535215..6535748) 1 NC_003155.4 PadR-family transcriptional regulator 6535748 1215960 SAV_5389 Streptomyces avermitilis MA-4680 PadR-family transcriptional regulator NP_826566.1 6535215 R 227882 CDS NP_826567.1 29831933 1215961 6535919..6536170 1 NC_003155.4 hypothetical protein 6536170 1215961 SAV_5390 Streptomyces avermitilis MA-4680 hypothetical protein NP_826567.1 6535919 D 227882 CDS NP_826568.1 29831934 1211264 6536171..6538393 1 NC_003155.4 4-alpha-glucanotransferase 6538393 malQ 1211264 malQ Streptomyces avermitilis MA-4680 4-alpha-glucanotransferase NP_826568.1 6536171 D 227882 CDS NP_826569.1 29831935 1215962 6538495..6538734 1 NC_003155.4 hypothetical protein 6538734 1215962 SAV_5392 Streptomyces avermitilis MA-4680 hypothetical protein NP_826569.1 6538495 D 227882 CDS NP_826570.1 29831936 1215963 complement(6538935..6539465) 1 NC_003155.4 MarR family transcriptional regulator 6539465 1215963 SAV_5393 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_826570.1 6538935 R 227882 CDS NP_826571.1 29831937 1215964 6539576..6540685 1 NC_003155.4 PF00892: Integral membrane protein DUF6; hypothetical protein 6540685 1215964 SAV_5394 Streptomyces avermitilis MA-4680 hypothetical protein NP_826571.1 6539576 D 227882 CDS NP_826572.1 29831938 1211265 complement(6540741..6543314) 1 NC_003155.4 PF01433: Peptidase family M1; aminopeptidase N 6543314 pepN1 1211265 pepN1 Streptomyces avermitilis MA-4680 aminopeptidase N NP_826572.1 6540741 R 227882 CDS NP_826573.1 29831939 1215965 6543427..6543948 1 NC_003155.4 PF06718: Protein of unknown function (DUF1203); hypothetical protein 6543948 1215965 SAV_5396 Streptomyces avermitilis MA-4680 hypothetical protein NP_826573.1 6543427 D 227882 CDS NP_826574.1 29831940 1211266 complement(6543990..6545006) 1 NC_003155.4 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 6545006 asd2 1211266 asd2 Streptomyces avermitilis MA-4680 aspartate-semialdehyde dehydrogenase NP_826574.1 6543990 R 227882 CDS NP_826575.1 29831941 1211267 6545341..6545880 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 6545880 sig46 1211267 sig46 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_826575.1 6545341 D 227882 CDS NP_826576.1 29831942 1215966 6545882..6546634 1 NC_003155.4 hypothetical protein 6546634 1215966 SAV_5399 Streptomyces avermitilis MA-4680 hypothetical protein NP_826576.1 6545882 D 227882 CDS NP_826577.1 29831943 1215967 complement(6546704..6550009) 1 NC_003155.4 PF00082: Subtilase family; serine protease 6550009 1215967 SAV_5400 Streptomyces avermitilis MA-4680 serine protease NP_826577.1 6546704 R 227882 CDS NP_826578.1 29831944 1215968 complement(6550265..6550801) 1 NC_003155.4 PF07336: Protein of unknown function (DUF1470); hypothetical protein 6550801 1215968 SAV_5401 Streptomyces avermitilis MA-4680 hypothetical protein NP_826578.1 6550265 R 227882 CDS NP_826579.1 29831945 1215969 6550921..6551373 1 NC_003155.4 lactoylglutathione lyase 6551373 gloA 1215969 gloA Streptomyces avermitilis MA-4680 lactoylglutathione lyase NP_826579.1 6550921 D 227882 CDS NP_826580.1 29831946 1215970 6551389..6552270 1 NC_003155.4 PF01243: Pyridoxamine 5'-phosphate oxidase; hypothetical protein 6552270 1215970 SAV_5403 Streptomyces avermitilis MA-4680 hypothetical protein NP_826580.1 6551389 D 227882 CDS NP_826581.1 29831947 1215971 6552280..6552738 1 NC_003155.4 PF00293: NUDIX domain; hypothetical protein 6552738 1215971 SAV_5404 Streptomyces avermitilis MA-4680 hypothetical protein NP_826581.1 6552280 D 227882 CDS NP_826582.1 29831948 1215972 6552981..6554771 1 NC_003155.4 PF00149: Calcineurin-like phosphoesterase; hypothetical protein 6554771 1215972 SAV_5405 Streptomyces avermitilis MA-4680 hypothetical protein NP_826582.1 6552981 D 227882 CDS NP_826583.1 29831949 1215973 complement(6554938..6556161) 1 NC_003155.4 PF01833: IPT/TIG domain; hypothetical protein 6556161 1215973 SAV_5406 Streptomyces avermitilis MA-4680 hypothetical protein NP_826583.1 6554938 R 227882 CDS NP_826584.1 29831950 1215974 complement(6556529..6556738) 1 NC_003155.4 PF04149: Domain of unknown function (DUF397); hypothetical protein 6556738 1215974 SAV_5407 Streptomyces avermitilis MA-4680 hypothetical protein NP_826584.1 6556529 R 227882 CDS NP_826585.1 29831951 1215975 complement(6556743..6557630) 1 NC_003155.4 DNA-binding protein 6557630 1215975 SAV_5408 Streptomyces avermitilis MA-4680 DNA-binding protein NP_826585.1 6556743 R 227882 CDS NP_826586.1 29831952 1215976 6557797..6558324 1 NC_003155.4 regulatory protein 6558324 1215976 SAV_5409 Streptomyces avermitilis MA-4680 regulatory protein NP_826586.1 6557797 D 227882 CDS NP_826587.1 29831953 1215977 complement(6558356..6559105) 1 NC_003155.4 hypothetical protein 6559105 1215977 SAV_5410 Streptomyces avermitilis MA-4680 hypothetical protein NP_826587.1 6558356 R 227882 CDS NP_826588.1 29831954 1215978 complement(6559622..6562129) 1 NC_003155.4 PF01433: Peptidase family M1; aminopeptidase N 6562129 pepN2 1215978 pepN2 Streptomyces avermitilis MA-4680 aminopeptidase N NP_826588.1 6559622 R 227882 CDS NP_826589.1 29831955 1215979 6562354..6562992 1 NC_003155.4 PF01323: DSBA-like thioredoxin domain; hypothetical protein 6562992 1215979 SAV_5412 Streptomyces avermitilis MA-4680 hypothetical protein NP_826589.1 6562354 D 227882 CDS NP_826590.1 29831956 1211268 complement(6563423..6564064) 1 NC_003155.4 Fe-containing superoxide dismutase; superoxide dismutase 6564064 sodF 1211268 sodF Streptomyces avermitilis MA-4680 superoxide dismutase NP_826590.1 6563423 R 227882 CDS NP_826591.1 29831957 1215980 complement(6564205..6565593) 1 NC_003155.4 amino acid permease 6565593 1215980 SAV_5414 Streptomyces avermitilis MA-4680 amino acid permease NP_826591.1 6564205 R 227882 CDS NP_826592.1 29831958 1215981 complement(6565752..6566651) 1 NC_003155.4 PF02668: Taurine catabolism dioxygenase TauD, TfdA family; taurine catabolism dioxygenase 6566651 1215981 SAV_5415 Streptomyces avermitilis MA-4680 taurine catabolism dioxygenase NP_826592.1 6565752 R 227882 CDS NP_826593.1 29831959 1215982 complement(6566666..6568027) 1 NC_003155.4 FMNH2-utilizing oxygenase 6568027 1215982 SAV_5416 Streptomyces avermitilis MA-4680 FMNH2-utilizing oxygenase NP_826593.1 6566666 R 227882 CDS NP_826594.1 29831960 1215983 complement(6568024..6568776) 1 NC_003155.4 ABC transporter ATP-binding protein 6568776 1215983 SAV_5417 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_826594.1 6568024 R 227882 CDS NP_826595.1 29831961 1215984 complement(6568752..6569624) 1 NC_003155.4 ABC transporter permease 6569624 1215984 SAV_5418 Streptomyces avermitilis MA-4680 ABC transporter permease NP_826595.1 6568752 R 227882 CDS NP_826596.1 29831962 1215985 complement(6569630..6570703) 1 NC_003155.4 PF00497: Bacterial extracellular solute-binding proteins, family 3; hypothetical protein 6570703 1215985 SAV_5419 Streptomyces avermitilis MA-4680 hypothetical protein NP_826596.1 6569630 R 227882 CDS NP_826597.1 29831963 1215986 complement(6571037..6572269) 1 NC_003155.4 transcriptional regulator 6572269 1215986 SAV_5420 Streptomyces avermitilis MA-4680 transcriptional regulator NP_826597.1 6571037 R 227882 CDS NP_826598.1 29831964 1211269 6572704..6573285 1 NC_003155.4 biotin synthase 6573285 bioY 1211269 bioY Streptomyces avermitilis MA-4680 biotin synthase NP_826598.1 6572704 D 227882 CDS NP_826599.1 29831965 1215987 complement(6573275..6574636) 1 NC_003155.4 FAD-dependent oxygenase 6574636 1215987 SAV_5422 Streptomyces avermitilis MA-4680 FAD-dependent oxygenase NP_826599.1 6573275 R 227882 CDS NP_826600.1 29831966 1215988 complement(6574704..6575474) 1 NC_003155.4 hypothetical protein 6575474 1215988 SAV_5423 Streptomyces avermitilis MA-4680 hypothetical protein NP_826600.1 6574704 R 227882 CDS NP_826601.1 29831967 1211270 6575595..6578006 1 NC_003155.4 serine/threonine protein kinase 6578006 pkn27 1211270 pkn27 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_826601.1 6575595 D 227882 CDS NP_826602.1 29831968 1211271 complement(6578092..6579576) 1 NC_003155.4 gamma-aminobutyrate permease 6579576 gabP 1211271 gabP Streptomyces avermitilis MA-4680 gamma-aminobutyrate permease NP_826602.1 6578092 R 227882 CDS NP_826603.1 29831969 1211272 6579813..6580292 1 NC_003155.4 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity; ribose-5-phosphate isomerase B 6580292 rpiB2 1211272 rpiB2 Streptomyces avermitilis MA-4680 ribose-5-phosphate isomerase B NP_826603.1 6579813 D 227882 CDS NP_826604.1 29831970 1215989 6580410..6581219 1 NC_003155.4 involved in DNA repair; nick DNA at apurinic/apyrimidinic sites; endonuclease VIII and DNA N-glycosylase with an AP lyase activity 6581219 nei2 1215989 nei2 Streptomyces avermitilis MA-4680 endonuclease VIII and DNA N-glycosylase with an AP lyase activity NP_826604.1 6580410 D 227882 CDS NP_826605.1 29831971 1215990 complement(6581347..6582576) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; hypothetical protein 6582576 1215990 SAV_5428 Streptomyces avermitilis MA-4680 hypothetical protein NP_826605.1 6581347 R 227882 CDS NP_826606.1 29831972 1215991 6582735..6583910 1 NC_003155.4 membrane protein; magnesium or manganese-dependent protein phosphatase 6583910 prpB11 1215991 prpB11 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_826606.1 6582735 D 227882 CDS NP_826607.1 29831973 1215992 6584175..6585122 1 NC_003155.4 ABC transporter ATP-binding protein 6585122 1215992 SAV_5430 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_826607.1 6584175 D 227882 CDS NP_826608.1 29831974 1215993 6585128..6587572 1 NC_003155.4 hypothetical protein 6587572 1215993 SAV_5431 Streptomyces avermitilis MA-4680 hypothetical protein NP_826608.1 6585128 D 227882 CDS NP_826609.1 29831975 1215994 6587774..6588106 1 NC_003155.4 hypothetical protein 6588106 1215994 SAV_5432 Streptomyces avermitilis MA-4680 hypothetical protein NP_826609.1 6587774 D 227882 CDS NP_826610.1 29831976 1215995 6588160..6588474 1 NC_003155.4 hypothetical protein 6588474 1215995 SAV_5433 Streptomyces avermitilis MA-4680 hypothetical protein NP_826610.1 6588160 D 227882 CDS NP_826611.1 29831977 1215996 6588533..6588928 1 NC_003155.4 hypothetical protein 6588928 1215996 SAV_5434 Streptomyces avermitilis MA-4680 hypothetical protein NP_826611.1 6588533 D 227882 CDS NP_826612.1 29831978 1215997 6588925..6591399 1 NC_003155.4 PF03496: Clostridial binary toxin A; hypothetical protein 6591399 1215997 SAV_5435 Streptomyces avermitilis MA-4680 hypothetical protein NP_826612.1 6588925 D 227882 CDS NP_826613.1 29831979 1215998 6591450..6591863 1 NC_003155.4 hypothetical protein 6591863 1215998 SAV_5436 Streptomyces avermitilis MA-4680 hypothetical protein NP_826613.1 6591450 D 227882 CDS NP_826614.1 29831980 1215999 6591994..6592602 1 NC_003155.4 hypothetical protein 6592602 1215999 SAV_5437 Streptomyces avermitilis MA-4680 hypothetical protein NP_826614.1 6591994 D 227882 CDS NP_826615.1 29831981 1216000 6592636..6593160 1 NC_003155.4 PF01966: HD domain; hypothetical protein 6593160 1216000 SAV_5438 Streptomyces avermitilis MA-4680 hypothetical protein NP_826615.1 6592636 D 227882 CDS NP_826616.1 29831982 1216001 complement(6593234..6593497) 1 NC_003155.4 hypothetical protein 6593497 1216001 SAV_5439 Streptomyces avermitilis MA-4680 hypothetical protein NP_826616.1 6593234 R 227882 CDS NP_826617.1 29831983 1216002 6593623..6594978 1 NC_003155.4 PF04600: Protein of unknown function (DUF571); hypothetical protein 6594978 1216002 SAV_5440 Streptomyces avermitilis MA-4680 hypothetical protein NP_826617.1 6593623 D 227882 CDS NP_826618.1 29831984 1216003 6595249..6596349 1 NC_003155.4 PF01656: CobQ/CobB/MinD/ParA nucleotide binding domain; hypothetical protein 6596349 1216003 SAV_5441 Streptomyces avermitilis MA-4680 hypothetical protein NP_826618.1 6595249 D 227882 CDS NP_826619.1 29831985 1216004 6596371..6600345 1 NC_003155.4 FtsK/SpoIIIE family protein 6600345 1216004 SAV_5442 Streptomyces avermitilis MA-4680 FtsK/SpoIIIE family protein NP_826619.1 6596371 D 227882 CDS NP_826620.1 29831986 1216005 6600481..6601911 1 NC_003155.4 hypothetical protein 6601911 1216005 SAV_5443 Streptomyces avermitilis MA-4680 hypothetical protein NP_826620.1 6600481 D 227882 CDS NP_826621.1 29831987 1216006 complement(6602030..6603157) 1 NC_003155.4 PF01757: acyltransferase family; hypothetical protein 6603157 1216006 SAV_5444 Streptomyces avermitilis MA-4680 hypothetical protein NP_826621.1 6602030 R 227882 CDS NP_826622.1 29831988 1216007 6603863..6604057 1 NC_003155.4 hypothetical protein 6604057 1216007 SAV_5445 Streptomyces avermitilis MA-4680 hypothetical protein NP_826622.1 6603863 D 227882 CDS NP_826623.1 29831989 1211275 6604924..6606315 1 NC_003155.4 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 6606315 tig 1211275 tig Streptomyces avermitilis MA-4680 trigger factor NP_826623.1 6604924 D 227882 CDS NP_826624.1 29831990 1211276 6607644..6608303 1 NC_003155.4 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 6608303 clpP 1211276 clpP Streptomyces avermitilis MA-4680 ATP-dependent Clp protease proteolytic subunit NP_826624.1 6607644 D 227882 CDS NP_826625.1 29831991 1211277 6608414..6609094 1 NC_003155.4 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 6609094 clpP2 1211277 clpP2 Streptomyces avermitilis MA-4680 ATP-dependent Clp protease proteolytic subunit NP_826625.1 6608414 D 227882 CDS NP_826626.1 29831992 1211278 6609255..6610541 1 NC_003155.4 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 6610541 clpX 1211278 clpX Streptomyces avermitilis MA-4680 ATP-dependent protease ATP-binding subunit ClpX NP_826626.1 6609255 D 227882 CDS NP_826627.1 29831993 1216008 complement(6610652..6611620) 1 NC_003155.4 hypothetical protein 6611620 1216008 SAV_5450 Streptomyces avermitilis MA-4680 hypothetical protein NP_826627.1 6610652 R 227882 CDS NP_826628.1 29831994 1211279 6611757..6614381 1 NC_003155.4 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 6614381 valS 1211279 valS Streptomyces avermitilis MA-4680 valyl-tRNA synthetase NP_826628.1 6611757 D 227882 CDS NP_826629.1 29831995 1211280 6614987..6616348 1 NC_003155.4 folylpolyglutamate synthase 6616348 fpgS 1211280 fpgS Streptomyces avermitilis MA-4680 folylpolyglutamate synthase NP_826629.1 6614987 D 227882 CDS NP_826630.1 29831996 1216009 6616354..6616722 1 NC_003155.4 hypothetical protein 6616722 1216009 SAV_5453 Streptomyces avermitilis MA-4680 hypothetical protein NP_826630.1 6616354 D 227882 CDS NP_826631.1 29831997 1211281 6616789..6617202 1 NC_003155.4 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 6617202 ndk 1211281 ndk Streptomyces avermitilis MA-4680 nucleoside diphosphate kinase NP_826631.1 6616789 D 227882 CDS NP_826632.1 29831998 1211282 6617490..6618521 1 NC_003155.4 functions in MreBCD complex in some organisms; rod shape-determining protein MreB 6618521 mreB1 1211282 mreB1 Streptomyces avermitilis MA-4680 rod shape-determining protein MreB NP_826632.1 6617490 D 227882 CDS NP_826633.1 29831999 1211283 6618682..6619626 1 NC_003155.4 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 6619626 mreC 1211283 mreC Streptomyces avermitilis MA-4680 rod shape-determining protein MreC NP_826633.1 6618682 D 227882 CDS NP_826634.1 29832000 1211284 6619640..6620311 1 NC_003155.4 PF04093: rod shape-determining protein MreD; rod shape-determining protein 6620311 mreD 1211284 mreD Streptomyces avermitilis MA-4680 rod shape-determining protein NP_826634.1 6619640 D 227882 CDS NP_826635.1 29832001 1211285 6620398..6622647 1 NC_003155.4 PF00905: Penicillin binding protein transpeptidase domain; penicillin-binding protein 6622647 pbp10 1211285 pbp10 Streptomyces avermitilis MA-4680 penicillin-binding protein NP_826635.1 6620398 D 227882 CDS NP_826636.1 29832002 1211286 6622682..6623878 1 NC_003155.4 PF01098: Cell cycle protein; cell division membrane protein 6623878 ftsW2 1211286 ftsW2 Streptomyces avermitilis MA-4680 cell division membrane protein NP_826636.1 6622682 D 227882 CDS NP_826637.1 29832003 1216010 6624084..6625607 1 NC_003155.4 hypothetical protein 6625607 1216010 SAV_5460 Streptomyces avermitilis MA-4680 hypothetical protein NP_826637.1 6624084 D 227882 CDS NP_826638.1 29832004 1216011 6625678..6627636 1 NC_003155.4 PF04055: radical SAM superfamily; hypothetical protein 6627636 1216011 SAV_5461 Streptomyces avermitilis MA-4680 hypothetical protein NP_826638.1 6625678 D 227882 CDS NP_826639.1 29832005 1216012 complement(6627793..6629124) 1 NC_003155.4 hypothetical protein 6629124 1216012 SAV_5462 Streptomyces avermitilis MA-4680 hypothetical protein NP_826639.1 6627793 R 227882 CDS NP_826640.1 29832006 1216013 6629472..6630719 1 NC_003155.4 integral membrane protein 6630719 1216013 SAV_5463 Streptomyces avermitilis MA-4680 integral membrane protein NP_826640.1 6629472 D 227882 CDS NP_826641.1 29832007 1216014 6630766..6631560 1 NC_003155.4 hypothetical protein 6631560 1216014 SAV_5464 Streptomyces avermitilis MA-4680 hypothetical protein NP_826641.1 6630766 D 227882 CDS NP_826642.1 29832008 1216015 6631806..6635969 1 NC_003155.4 PF00575: S1 RNA binding domain; hypothetical protein 6635969 1216015 SAV_5465 Streptomyces avermitilis MA-4680 hypothetical protein NP_826642.1 6631806 D 227882 CDS NP_826643.1 29832009 1216016 6636201..6637550 1 NC_003155.4 hypothetical protein 6637550 1216016 SAV_5466 Streptomyces avermitilis MA-4680 hypothetical protein NP_826643.1 6636201 D 227882 CDS NP_826644.1 29832010 1211287 6637749..6638069 1 NC_003155.4 50S ribosomal protein L21 6638069 rplU 1211287 rplU Streptomyces avermitilis MA-4680 50S ribosomal protein L21 NP_826644.1 6637749 D 227882 CDS NP_826645.1 29832011 1211288 6638084..6638338 1 NC_003155.4 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 6638338 rpmA 1211288 rpmA Streptomyces avermitilis MA-4680 50S ribosomal protein L27 NP_826645.1 6638084 D 227882 CDS NP_826646.1 29832012 1211289 6638508..6639947 1 NC_003155.4 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 6639947 obgE 1211289 obgE Streptomyces avermitilis MA-4680 GTPase ObgE NP_826646.1 6638508 D 227882 CDS NP_826647.1 29832013 1216017 complement(6640249..6642423) 1 NC_003155.4 hypothetical protein 6642423 1216017 SAV_5470 Streptomyces avermitilis MA-4680 hypothetical protein NP_826647.1 6640249 R 227882 CDS NP_826648.1 29832014 1211290 6642604..6643731 1 NC_003155.4 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 6643731 proB 1211290 proB Streptomyces avermitilis MA-4680 gamma-glutamyl kinase NP_826648.1 6642604 D 227882 CDS NP_826649.1 29832015 1216018 6643870..6644415 1 NC_003155.4 hypothetical protein 6644415 1216018 SAV_5472 Streptomyces avermitilis MA-4680 hypothetical protein NP_826649.1 6643870 D 227882 CDS NP_826650.1 29832016 1211291 6644624..6645910 1 NC_003155.4 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 6645910 proA 1211291 proA Streptomyces avermitilis MA-4680 gamma-glutamyl phosphate reductase NP_826650.1 6644624 D 227882 CDS NP_826651.1 29832017 1216019 6645936..6646688 1 NC_003155.4 hypothetical protein 6646688 1216019 SAV_5474 Streptomyces avermitilis MA-4680 hypothetical protein NP_826651.1 6645936 D 227882 CDS NP_826652.1 29832018 1216020 6646898..6647965 1 NC_003155.4 PF00866: Ring hydroxylating beta subunit; hypothetical protein 6647965 1216020 SAV_5475 Streptomyces avermitilis MA-4680 hypothetical protein NP_826652.1 6646898 D 227882 CDS NP_826653.1 29832019 1216021 complement(6648111..6649241) 1 NC_003155.4 PF01435: Peptidase family M48; hypothetical protein 6649241 1216021 SAV_5476 Streptomyces avermitilis MA-4680 hypothetical protein NP_826653.1 6648111 R 227882 CDS NP_826654.1 29832020 1216022 6649647..6649811 1 NC_003155.4 hypothetical protein 6649811 1216022 SAV_5477 Streptomyces avermitilis MA-4680 hypothetical protein NP_826654.1 6649647 D 227882 CDS NP_826655.1 29832021 1211292 6649972..6650646 1 NC_003155.4 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 6650646 nadD 1211292 nadD Streptomyces avermitilis MA-4680 nicotinic acid mononucleotide adenylyltransferase NP_826655.1 6649972 D 227882 CDS NP_826656.1 29832022 1216023 6650663..6652465 1 NC_003155.4 PF03816: Cell envelope-related transcriptional attenuator domain; hypothetical protein 6652465 1216023 SAV_5479 Streptomyces avermitilis MA-4680 hypothetical protein NP_826656.1 6650663 D 227882 CDS NP_826657.1 29832023 1216024 6652631..6653077 1 NC_003155.4 PF02410: Domain of unknown function DUF143; hypothetical protein 6653077 1216024 SAV_5480 Streptomyces avermitilis MA-4680 hypothetical protein NP_826657.1 6652631 D 227882 CDS NP_826658.1 29832024 1211293 6653074..6653748 1 NC_003155.4 phosphoglycerate mutase 6653748 gpm2 1211293 gpm2 Streptomyces avermitilis MA-4680 phosphoglycerate mutase NP_826658.1 6653074 D 227882 CDS NP_826659.1 29832025 1216025 complement(6654016..6654909) 1 NC_003155.4 DNA-binding protein 6654909 1216025 SAV_5482 Streptomyces avermitilis MA-4680 DNA-binding protein NP_826659.1 6654016 R 227882 CDS NP_826660.1 29832026 1216026 6655058..6656494 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane transport protein 6656494 1216026 SAV_5483 Streptomyces avermitilis MA-4680 transmembrane transport protein NP_826660.1 6655058 D 227882 CDS NP_826661.1 29832027 1216027 6656741..6656974 1 NC_003155.4 hypothetical protein 6656974 1216027 SAV_5484 Streptomyces avermitilis MA-4680 hypothetical protein NP_826661.1 6656741 D 227882 CDS NP_826662.1 29832028 1216028 complement(6656953..6658167) 1 NC_003155.4 hypothetical protein 6658167 1216028 SAV_5485 Streptomyces avermitilis MA-4680 hypothetical protein NP_826662.1 6656953 R 227882 CDS NP_826663.1 29832029 1216029 complement(6658504..6660078) 1 NC_003155.4 PF01512: Respiratory-chain NADH dehydrogenase 51 Kd subunit; oxidoreductase 6660078 1216029 SAV_5486 Streptomyces avermitilis MA-4680 oxidoreductase NP_826663.1 6658504 R 227882 CDS NP_826664.1 29832030 1216030 complement(6660114..6661424) 1 NC_003155.4 integral membrane protein 6661424 1216030 SAV_5487 Streptomyces avermitilis MA-4680 integral membrane protein NP_826664.1 6660114 R 227882 CDS NP_826665.1 29832031 1211296 6661895..6664783 1 NC_003155.4 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 6664783 leuS 1211296 leuS Streptomyces avermitilis MA-4680 leucyl-tRNA synthetase NP_826665.1 6661895 D 227882 CDS NP_826666.1 29832032 1216031 6664923..6665660 1 NC_003155.4 protein 6665660 1216031 SAV_5489 Streptomyces avermitilis MA-4680 protein NP_826666.1 6664923 D 227882 CDS NP_826667.1 29832033 1216032 6665733..6666578 1 NC_003155.4 PF02645: Uncharacterized protein, DegV family COG1307; hypothetical protein 6666578 1216032 SAV_5490 Streptomyces avermitilis MA-4680 hypothetical protein NP_826667.1 6665733 D 227882 CDS NP_826668.1 29832034 1216033 6666768..6667931 1 NC_003155.4 DNA-binding protein 6667931 1216033 SAV_5491 Streptomyces avermitilis MA-4680 DNA-binding protein NP_826668.1 6666768 D 227882 CDS NP_826669.1 29832035 1216034 6667928..6670450 1 NC_003155.4 PF03772: Competence protein; hypothetical protein 6670450 1216034 SAV_5492 Streptomyces avermitilis MA-4680 hypothetical protein NP_826669.1 6667928 D 227882 CDS NP_826670.1 29832036 1216035 6670511..6670789 1 NC_003155.4 probably phage genome; hypothetical protein 6670789 1216035 SAV_5493 Streptomyces avermitilis MA-4680 hypothetical protein NP_826670.1 6670511 D 227882 CDS NP_826671.1 29832037 1216036 6671196..6671525 1 NC_003155.4 probably phage genome; hypothetical protein 6671525 1216036 SAV_5494 Streptomyces avermitilis MA-4680 hypothetical protein NP_826671.1 6671196 D 227882 CDS NP_826672.1 29832038 1216037 complement(6671598..6671918) 1 NC_003155.4 probably phage genome; hypothetical protein 6671918 1216037 SAV_5495 Streptomyces avermitilis MA-4680 hypothetical protein NP_826672.1 6671598 R 227882 CDS NP_826673.1 29832039 1216038 complement(6672034..6672387) 1 NC_003155.4 probably phage genome; hypothetical protein 6672387 1216038 SAV_5496 Streptomyces avermitilis MA-4680 hypothetical protein NP_826673.1 6672034 R 227882 CDS NP_826674.1 29832040 1216039 6672529..6673287 1 NC_003155.4 probably phage genome; GntR family transcriptional regulator 6673287 1216039 SAV_5497 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_826674.1 6672529 D 227882 CDS NP_826675.1 29832041 1216040 complement(6673473..6674246) 1 NC_003155.4 probably phage genome, similar to phage structural protein; N-acetylmuramoyl-L-alanine amidase precursor 6674246 1216040 SAV_5498 Streptomyces avermitilis MA-4680 N-acetylmuramoyl-L-alanine amidase precursor NP_826675.1 6673473 R 227882 CDS NP_826676.1 29832042 1216041 complement(6674323..6674634) 1 NC_003155.4 probably phage genome; hypothetical protein 6674634 1216041 SAV_5499 Streptomyces avermitilis MA-4680 hypothetical protein NP_826676.1 6674323 R 227882 CDS NP_826677.1 29832043 1216042 complement(6674649..6674873) 1 NC_003155.4 probably phage genome; hypothetical protein 6674873 1216042 SAV_5500 Streptomyces avermitilis MA-4680 hypothetical protein NP_826677.1 6674649 R 227882 CDS NP_826678.1 29832044 1216043 complement(6674875..6675222) 1 NC_003155.4 probably phage genome; hypothetical protein 6675222 1216043 SAV_5501 Streptomyces avermitilis MA-4680 hypothetical protein NP_826678.1 6674875 R 227882 CDS NP_826679.1 29832045 1216044 complement(6675313..6676260) 1 NC_003155.4 probably phage genome; hypothetical protein 6676260 1216044 SAV_5502 Streptomyces avermitilis MA-4680 hypothetical protein NP_826679.1 6675313 R 227882 CDS NP_826680.1 29832046 1216045 complement(6676364..6676564) 1 NC_003155.4 probably phage genome; hypothetical protein 6676564 1216045 SAV_5503 Streptomyces avermitilis MA-4680 hypothetical protein NP_826680.1 6676364 R 227882 CDS NP_826681.1 29832047 1216046 complement(6676585..6678273) 1 NC_003155.4 probably phage genome; hypothetical protein 6678273 1216046 SAV_5504 Streptomyces avermitilis MA-4680 hypothetical protein NP_826681.1 6676585 R 227882 CDS NP_826682.1 29832048 1216047 complement(6678303..6679331) 1 NC_003155.4 probably phage genome, similar to phage structure protein; hypothetical protein 6679331 1216047 SAV_5505 Streptomyces avermitilis MA-4680 hypothetical protein NP_826682.1 6678303 R 227882 CDS NP_826683.1 29832049 1216048 complement(6679345..6680535) 1 NC_003155.4 probably phage genome; hypothetical protein 6680535 1216048 SAV_5506 Streptomyces avermitilis MA-4680 hypothetical protein NP_826683.1 6679345 R 227882 CDS NP_826684.1 29832050 1216049 complement(6680539..6681474) 1 NC_003155.4 probably phage genome; hypothetical protein 6681474 1216049 SAV_5507 Streptomyces avermitilis MA-4680 hypothetical protein NP_826684.1 6680539 R 227882 CDS NP_826685.1 29832051 1216050 complement(6681496..6684924) 1 NC_003155.4 probably phage genome, similar to phage tail protein; phage minor tail protein 6684924 1216050 SAV_5508 Streptomyces avermitilis MA-4680 phage minor tail protein NP_826685.1 6681496 R 227882 CDS NP_826686.1 29832052 1216051 complement(6684968..6685366) 1 NC_003155.4 probably phage genome; hypothetical protein 6685366 1216051 SAV_5509 Streptomyces avermitilis MA-4680 hypothetical protein NP_826686.1 6684968 R 227882 CDS NP_826687.1 29832053 1216052 complement(6685465..6685797) 1 NC_003155.4 probably phage genome; hypothetical protein 6685797 1216052 SAV_5510 Streptomyces avermitilis MA-4680 hypothetical protein NP_826687.1 6685465 R 227882 CDS NP_826688.1 29832054 1216053 complement(6685951..6686568) 1 NC_003155.4 probably phage genome, similar to phage structure protein; phage major tail protein 6686568 1216053 SAV_5511 Streptomyces avermitilis MA-4680 phage major tail protein NP_826688.1 6685951 R 227882 CDS NP_826689.1 29832055 1216054 complement(6686629..6687072) 1 NC_003155.4 probably phage genome; hypothetical protein 6687072 1216054 SAV_5512 Streptomyces avermitilis MA-4680 hypothetical protein NP_826689.1 6686629 R 227882 CDS NP_826690.1 29832056 1216055 complement(6687091..6687330) 1 NC_003155.4 probably phage genome; hypothetical protein 6687330 1216055 SAV_5513 Streptomyces avermitilis MA-4680 hypothetical protein NP_826690.1 6687091 R 227882 CDS NP_826691.1 29832057 1216056 complement(6687334..6687618) 1 NC_003155.4 probably phage genome; hypothetical protein 6687618 1216056 SAV_5514 Streptomyces avermitilis MA-4680 hypothetical protein NP_826691.1 6687334 R 227882 CDS NP_826692.1 29832058 1216057 complement(6687618..6687959) 1 NC_003155.4 probably phage genome; hypothetical protein 6687959 1216057 SAV_5515 Streptomyces avermitilis MA-4680 hypothetical protein NP_826692.1 6687618 R 227882 CDS NP_826693.1 29832059 1216058 complement(6687963..6688358) 1 NC_003155.4 probably phage genome; hypothetical protein 6688358 1216058 SAV_5516 Streptomyces avermitilis MA-4680 hypothetical protein NP_826693.1 6687963 R 227882 CDS NP_826694.1 29832060 1216059 complement(6688378..6688713) 1 NC_003155.4 probably phage genome; hypothetical protein 6688713 1216059 SAV_5517 Streptomyces avermitilis MA-4680 hypothetical protein NP_826694.1 6688378 R 227882 CDS NP_826695.1 29832061 1216060 complement(6688744..6690066) 1 NC_003155.4 probably phage genome; hypothetical protein 6690066 1216060 SAV_5518 Streptomyces avermitilis MA-4680 hypothetical protein NP_826695.1 6688744 R 227882 CDS NP_826696.1 29832062 1216061 complement(6690082..6690711) 1 NC_003155.4 probably phage genome, PF06810: Phage minor structural protein GP20; phage minor structural protein 6690711 1216061 SAV_5519 Streptomyces avermitilis MA-4680 phage minor structural protein NP_826696.1 6690082 R 227882 CDS NP_826697.1 29832063 1216062 complement(6690753..6692330) 1 NC_003155.4 probably phage genome, PF05126: Phage minor capsid protein; phage minor capsid protein 6692330 1216062 SAV_5520 Streptomyces avermitilis MA-4680 phage minor capsid protein NP_826697.1 6690753 R 227882 CDS NP_826698.1 29832064 1216063 complement(6692327..6693625) 1 NC_003155.4 probably phage genome, PF03237: Protein of unknown function DUF264; phage-related terminase large subunit 6693625 1216063 SAV_5521 Streptomyces avermitilis MA-4680 phage-related terminase large subunit NP_826698.1 6692327 R 227882 CDS NP_826699.1 29832065 1216064 complement(6693629..6694117) 1 NC_003155.4 probably phage genome, PF00196: Bacterial regulatory proteins, luxR family; hypothetical protein 6694117 1216064 SAV_5522 Streptomyces avermitilis MA-4680 hypothetical protein NP_826699.1 6693629 R 227882 CDS NP_826700.1 29832066 1216065 complement(6694605..6694850) 1 NC_003155.4 probably phage genome; hypothetical protein 6694850 1216065 SAV_5523 Streptomyces avermitilis MA-4680 hypothetical protein NP_826700.1 6694605 R 227882 CDS NP_826701.1 29832067 1216066 6695024..6695500 1 NC_003155.4 probably phage genome; hypothetical protein 6695500 1216066 SAV_5524 Streptomyces avermitilis MA-4680 hypothetical protein NP_826701.1 6695024 D 227882 CDS NP_826702.1 29832068 1216067 complement(6695516..6695725) 1 NC_003155.4 probably phage genome, PF00376: MerR family regulatory protein; MerR family transcriptional regulator 6695725 1216067 SAV_5525 Streptomyces avermitilis MA-4680 MerR family transcriptional regulator NP_826702.1 6695516 R 227882 CDS NP_826703.1 29832069 1216068 complement(6695861..6696484) 1 NC_003155.4 probably phage genome, PF03536: Salmonella virulence-associated 28kDa protein; hypothetical protein 6696484 1216068 SAV_5526 Streptomyces avermitilis MA-4680 hypothetical protein NP_826703.1 6695861 R 227882 CDS NP_826704.1 29832070 1216069 complement(6696583..6697143) 1 NC_003155.4 probably phage genome; hypothetical protein 6697143 1216069 SAV_5527 Streptomyces avermitilis MA-4680 hypothetical protein NP_826704.1 6696583 R 227882 CDS NP_826705.1 29832071 1216070 complement(6697257..6697772) 1 NC_003155.4 probably phage genome; hypothetical protein 6697772 1216070 SAV_5528 Streptomyces avermitilis MA-4680 hypothetical protein NP_826705.1 6697257 R 227882 CDS NP_826706.1 29832072 1216071 complement(6697861..6698022) 1 NC_003155.4 probably phage genome; hypothetical protein 6698022 1216071 SAV_5529 Streptomyces avermitilis MA-4680 hypothetical protein NP_826706.1 6697861 R 227882 CDS NP_826707.1 29832073 1216072 complement(6698032..6698700) 1 NC_003155.4 probably phage genome; hypothetical protein 6698700 1216072 SAV_5530 Streptomyces avermitilis MA-4680 hypothetical protein NP_826707.1 6698032 R 227882 CDS NP_826708.1 29832074 1216073 complement(6698718..6699254) 1 NC_003155.4 probably phage genome, PF05992: SbmA/BacA-like family; hypothetical protein 6699254 1216073 SAV_5531 Streptomyces avermitilis MA-4680 hypothetical protein NP_826708.1 6698718 R 227882 CDS NP_826709.1 29832075 1216074 complement(6699251..6699643) 1 NC_003155.4 probably phage genome; hypothetical protein 6699643 1216074 SAV_5532 Streptomyces avermitilis MA-4680 hypothetical protein NP_826709.1 6699251 R 227882 CDS NP_826710.1 29832076 1216075 complement(6699713..6700657) 1 NC_003155.4 probably phage genome; hypothetical protein 6700657 1216075 SAV_5533 Streptomyces avermitilis MA-4680 hypothetical protein NP_826710.1 6699713 R 227882 CDS NP_826711.1 29832077 1216076 complement(6700777..6701424) 1 NC_003155.4 probably phage genome; hypothetical protein 6701424 1216076 SAV_5534 Streptomyces avermitilis MA-4680 hypothetical protein NP_826711.1 6700777 R 227882 CDS NP_826712.1 29832078 1216077 complement(6702042..6702266) 1 NC_003155.4 probably phage genome; hypothetical protein 6702266 1216077 SAV_5535 Streptomyces avermitilis MA-4680 hypothetical protein NP_826712.1 6702042 R 227882 CDS NP_826713.1 29832079 1216078 complement(6702263..6703810) 1 NC_003155.4 probably phage genome, PF00145: C-5 cytosine-specific DNA methylase; type II restriction-modification system DNA cytosine-specific methylase 6703810 savM2 1216078 savM2 Streptomyces avermitilis MA-4680 type II restriction-modification system DNA cytosine-specific methylase NP_826713.1 6702263 R 227882 CDS NP_826714.1 29832080 1216079 complement(6703791..6704228) 1 NC_003155.4 probably phage genome; hypothetical protein 6704228 1216079 SAV_5537 Streptomyces avermitilis MA-4680 hypothetical protein NP_826714.1 6703791 R 227882 CDS NP_826715.1 29832081 1216080 complement(6704225..6704467) 1 NC_003155.4 probably phage genome; hypothetical protein 6704467 1216080 SAV_5538 Streptomyces avermitilis MA-4680 hypothetical protein NP_826715.1 6704225 R 227882 CDS NP_826716.1 29832082 1216081 complement(6704464..6704691) 1 NC_003155.4 probably phage genome; hypothetical protein 6704691 1216081 SAV_5539 Streptomyces avermitilis MA-4680 hypothetical protein NP_826716.1 6704464 R 227882 CDS NP_826717.1 29832083 1216082 complement(6704688..6705548) 1 NC_003155.4 probably phage genome, PF02498: BRO family, N-terminal domain; hypothetical protein 6705548 1216082 SAV_5540 Streptomyces avermitilis MA-4680 hypothetical protein NP_826717.1 6704688 R 227882 CDS NP_826718.1 29832084 1216083 6705772..6707229 1 NC_003155.4 probably phage genome; hypothetical protein 6707229 1216083 SAV_5541 Streptomyces avermitilis MA-4680 hypothetical protein NP_826718.1 6705772 D 227882 CDS NP_826719.1 29832085 1216084 6707666..6708007 1 NC_003155.4 probably phage genome; hypothetical protein 6708007 1216084 SAV_5542 Streptomyces avermitilis MA-4680 hypothetical protein NP_826719.1 6707666 D 227882 CDS NP_826720.1 29832086 1216085 6708308..6708553 1 NC_003155.4 probably phage genome; hypothetical protein 6708553 1216085 SAV_5543 Streptomyces avermitilis MA-4680 hypothetical protein NP_826720.1 6708308 D 227882 CDS NP_826721.1 29832087 1216086 6708562..6708810 1 NC_003155.4 probably phage genome; hypothetical protein 6708810 1216086 SAV_5544 Streptomyces avermitilis MA-4680 hypothetical protein NP_826721.1 6708562 D 227882 CDS NP_826722.1 29832088 1216087 6708789..6708980 1 NC_003155.4 probably phage genome; hypothetical protein 6708980 1216087 SAV_5545 Streptomyces avermitilis MA-4680 hypothetical protein NP_826722.1 6708789 D 227882 CDS NP_826723.1 29832089 1216088 6709042..6709416 1 NC_003155.4 probably phage genome; hypothetical protein 6709416 1216088 SAV_5546 Streptomyces avermitilis MA-4680 hypothetical protein NP_826723.1 6709042 D 227882 CDS NP_826724.1 29832090 1216089 6709505..6710344 1 NC_003155.4 probably phage genome; hypothetical protein 6710344 1216089 SAV_5547 Streptomyces avermitilis MA-4680 hypothetical protein NP_826724.1 6709505 D 227882 CDS NP_826725.1 29832091 1216090 complement(6710346..6711848) 1 NC_003155.4 probably phage genome, PF07508: Recombinase; integrase/recombinase 6711848 int13 1216090 int13 Streptomyces avermitilis MA-4680 integrase/recombinase NP_826725.1 6710346 R 227882 CDS NP_826726.1 29832092 1216091 6712190..6712546 1 NC_003155.4 probably phage genome; hypothetical protein 6712546 1216091 SAV_5549 Streptomyces avermitilis MA-4680 hypothetical protein NP_826726.1 6712190 D 227882 CDS NP_826727.1 29832093 1216092 complement(6712793..6713059) 1 NC_003155.4 probably phage genome, PF04149: Domain of unknown function (DUF397); hypothetical protein 6713059 1216092 SAV_5550 Streptomyces avermitilis MA-4680 hypothetical protein NP_826727.1 6712793 R 227882 CDS NP_826728.1 29832094 1216093 6713593..6714810 1 NC_003155.4 probably phage genome, PF06036: Streptomyces protein of unknown function (DUF921); hypothetical protein 6714810 1216093 SAV_5551 Streptomyces avermitilis MA-4680 hypothetical protein NP_826728.1 6713593 D 227882 CDS NP_826729.1 29832095 1211297 complement(6715156..6715797) 1 NC_003155.4 probably phage genome; transfer protein spdA 6715797 spdA3 1211297 spdA3 Streptomyces avermitilis MA-4680 transfer protein spdA NP_826729.1 6715156 R 227882 CDS NP_826730.1 29832096 1216094 complement(6717295..6717978) 1 NC_003155.4 probably phage genome; hypothetical protein 6717978 1216094 SAV_5553 Streptomyces avermitilis MA-4680 hypothetical protein NP_826730.1 6717295 R 227882 CDS NP_826731.1 29832097 1216095 complement(6719527..6719781) 1 NC_003155.4 probably phage genome; hypothetical protein 6719781 1216095 SAV_5554 Streptomyces avermitilis MA-4680 hypothetical protein NP_826731.1 6719527 R 227882 CDS NP_826732.1 29832098 1216096 complement(6719828..6721444) 1 NC_003155.4 probably phage genome, PF07508: Recombinase; integrase/recombinase 6721444 int14 1216096 int14 Streptomyces avermitilis MA-4680 integrase/recombinase NP_826732.1 6719828 R 227882 CDS NP_826733.1 29832099 1211298 6721702..6722541 1 NC_003155.4 PF00797: N-acetyltransferase; N-hydroxyarylamine O-acetyltransferase 6722541 nhoA 1211298 nhoA Streptomyces avermitilis MA-4680 N-hydroxyarylamine O-acetyltransferase NP_826733.1 6721702 D 227882 CDS NP_826734.1 29832100 1216097 6722688..6722933 1 NC_003155.4 hypothetical protein 6722933 1216097 SAV_5557 Streptomyces avermitilis MA-4680 hypothetical protein NP_826734.1 6722688 D 227882 CDS NP_826735.1 29832101 1216098 6723063..6724073 1 NC_003155.4 DNA-binding protein 6724073 1216098 SAV_5558 Streptomyces avermitilis MA-4680 DNA-binding protein NP_826735.1 6723063 D 227882 CDS NP_826736.1 29832102 1216099 6724127..6724297 1 NC_003155.4 hypothetical protein 6724297 1216099 SAV_5559 Streptomyces avermitilis MA-4680 hypothetical protein NP_826736.1 6724127 D 227882 CDS NP_826737.1 29832103 1211299 complement(6724561..6724827) 1 NC_003155.4 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 6724827 rpsT 1211299 rpsT Streptomyces avermitilis MA-4680 30S ribosomal protein S20 NP_826737.1 6724561 R 227882 CDS NP_826738.1 29832104 1211300 6725081..6726949 1 NC_003155.4 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 6726949 lepA 1211300 lepA Streptomyces avermitilis MA-4680 GTP-binding protein LepA NP_826738.1 6725081 D 227882 CDS NP_826739.1 29832105 1211301 6727208..6729118 1 NC_003155.4 PF00501: AMP-binding enzyme; acyl-CoA synthetase, long-chain fatty acid:CoA ligase 6729118 fadD12 1211301 fadD12 Streptomyces avermitilis MA-4680 acyl-CoA synthetase, long-chain fatty acid:CoA ligase NP_826739.1 6727208 D 227882 CDS NP_826740.1 29832106 1216100 complement(6729297..6729881) 1 NC_003155.4 two-component system response regulator 6729881 1216100 SAV_5563 Streptomyces avermitilis MA-4680 two-component system response regulator NP_826740.1 6729297 R 227882 CDS NP_826741.1 29832107 1216101 complement(6729894..6734045) 1 NC_003155.4 two-component system sensor kinase 6734045 1216101 SAV_5564 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_826741.1 6729894 R 227882 CDS NP_826742.1 29832108 1216102 6734148..6736367 1 NC_003155.4 PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; magnesium or manganese-dependent protein phosphatase 6736367 prpK 1216102 prpK Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_826742.1 6734148 D 227882 CDS NP_826743.1 29832109 1211302 6736403..6737635 1 NC_003155.4 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 6737635 hemN 1211302 hemN Streptomyces avermitilis MA-4680 coproporphyrinogen III oxidase NP_826743.1 6736403 D 227882 CDS NP_826744.1 29832110 1216103 complement(6737672..6738484) 1 NC_003155.4 hypothetical protein 6738484 1216103 SAV_5567 Streptomyces avermitilis MA-4680 hypothetical protein NP_826744.1 6737672 R 227882 CDS NP_826745.1 29832111 1211303 complement(6738590..6739318) 1 NC_003155.4 PF00753: Metallo-beta-lactamase superfamily; metallo-beta-lactamase 6739318 blaB3 1211303 blaB3 Streptomyces avermitilis MA-4680 metallo-beta-lactamase NP_826745.1 6738590 R 227882 CDS NP_826746.1 29832112 1211304 6739510..6740526 1 NC_003155.4 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 6740526 hrcA 1211304 hrcA Streptomyces avermitilis MA-4680 heat-inducible transcription repressor NP_826746.1 6739510 D 227882 CDS NP_826747.1 29832113 1211305 6740527..6741663 1 NC_003155.4 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 6741663 dnaJ3 1211305 dnaJ3 Streptomyces avermitilis MA-4680 chaperone protein DnaJ NP_826747.1 6740527 D 227882 CDS NP_826748.1 29832114 1216104 6741854..6742927 1 NC_003155.4 PF03060: 2-nitropropane dioxygenase; dioxygenase 6742927 1216104 SAV_5571 Streptomyces avermitilis MA-4680 dioxygenase NP_826748.1 6741854 D 227882 CDS NP_826749.1 29832115 1211306 6742924..6743673 1 NC_003155.4 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 6743673 sdrD 1211306 sdrD Streptomyces avermitilis MA-4680 16S ribosomal RNA methyltransferase RsmE NP_826749.1 6742924 D 227882 CDS NP_826750.1 29832116 1216105 6743895..6744527 1 NC_003155.4 lipoprotein 6744527 1216105 SAV_5573 Streptomyces avermitilis MA-4680 lipoprotein NP_826750.1 6743895 D 227882 CDS NP_826751.1 29832117 1216106 6744599..6747820 1 NC_003155.4 PF03572: Peptidase family S41; protease 6747820 1216106 SAV_5574 Streptomyces avermitilis MA-4680 protease NP_826751.1 6744599 D 227882 CDS NP_826752.1 29832118 1216107 6747919..6748272 1 NC_003155.4 PF01230: HIT domain; protein kinase C inhibitor 6748272 1216107 SAV_5575 Streptomyces avermitilis MA-4680 protein kinase C inhibitor NP_826752.1 6747919 D 227882 CDS NP_826753.1 29832119 1216108 6748279..6749184 1 NC_003155.4 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 6749184 1216108 SAV_5576 Streptomyces avermitilis MA-4680 ribonuclease Z NP_826753.1 6748279 D 227882 CDS NP_826754.1 29832120 1211307 6749205..6750206 1 NC_003155.4 catalyzes the formation of inosine from adenosine; adenosine deaminase 6750206 add5 1211307 add5 Streptomyces avermitilis MA-4680 adenosine deaminase NP_826754.1 6749205 D 227882 CDS NP_826755.1 29832121 1216109 complement(6750219..6751508) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 6751508 1216109 SAV_5578 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_826755.1 6750219 R 227882 CDS NP_826756.1 29832122 1216110 complement(6751740..6752531) 1 NC_003155.4 IclR family transcriptional regulator 6752531 1216110 SAV_5579 Streptomyces avermitilis MA-4680 IclR family transcriptional regulator NP_826756.1 6751740 R 227882 CDS NP_826757.1 29832123 1211308 6752657..6753652 1 NC_003155.4 catalyzes the formation of 2,5-dioxopentanoate from 5-dehydro-4-deoxy-D-glucarate; 5-dehydro-4-deoxyglucarate dehydratase 6753652 dapA3 1211308 dapA3 Streptomyces avermitilis MA-4680 5-dehydro-4-deoxyglucarate dehydratase NP_826757.1 6752657 D 227882 CDS NP_826758.1 29832124 1211309 6753649..6755235 1 NC_003155.4 glucarate dehydratase 6755235 gudD 1211309 gudD Streptomyces avermitilis MA-4680 glucarate dehydratase NP_826758.1 6753649 D 227882 CDS NP_826759.1 29832125 1216111 6755232..6756341 1 NC_003155.4 carbohydrate kinase 6756341 1216111 SAV_5582 Streptomyces avermitilis MA-4680 carbohydrate kinase NP_826759.1 6755232 D 227882 CDS NP_826760.1 29832126 1211310 6756537..6757604 1 NC_003155.4 phosphate starvation-induced protein 6757604 phoH 1211310 phoH Streptomyces avermitilis MA-4680 phosphate starvation-induced protein NP_826760.1 6756537 D 227882 CDS NP_826761.1 29832127 1216112 6757634..6758131 1 NC_003155.4 PF02130: Uncharacterized protein family UPF0054; putative metalloprotease 6758131 1216112 SAV_5584 Streptomyces avermitilis MA-4680 putative metalloprotease NP_826761.1 6757634 D 227882 CDS NP_826762.1 29832128 1216113 6758128..6759435 1 NC_003155.4 PF00571: CBS domain; transport protein 6759435 1216113 SAV_5585 Streptomyces avermitilis MA-4680 transport protein NP_826762.1 6758128 D 227882 CDS NP_826763.1 29832129 1216114 6759432..6759791 1 NC_003155.4 PF04237: Protein of unknown function (DUF419); MmcQ-like protein 6759791 1216114 SAV_5586 Streptomyces avermitilis MA-4680 MmcQ-like protein NP_826763.1 6759432 D 227882 CDS NP_826764.1 29832130 1216115 complement(6759753..6761222) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 6761222 1216115 SAV_5587 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_826764.1 6759753 R 227882 CDS NP_826765.1 29832131 1216116 6761429..6762298 1 NC_003155.4 DNA-binding protein 6762298 1216116 SAV_5588 Streptomyces avermitilis MA-4680 DNA-binding protein NP_826765.1 6761429 D 227882 CDS NP_826766.1 29832132 1216117 6762340..6762693 1 NC_003155.4 hypothetical protein 6762693 1216117 SAV_5589 Streptomyces avermitilis MA-4680 hypothetical protein NP_826766.1 6762340 D 227882 CDS NP_826767.1 29832133 1216118 6763077..6763556 1 NC_003155.4 hypothetical protein 6763556 1216118 SAV_5590 Streptomyces avermitilis MA-4680 hypothetical protein NP_826767.1 6763077 D 227882 CDS NP_826768.1 29832134 1216119 6763798..6765120 1 NC_003155.4 hypothetical protein 6765120 1216119 SAV_5591 Streptomyces avermitilis MA-4680 hypothetical protein NP_826768.1 6763798 D 227882 CDS NP_826769.1 29832135 1216120 6765261..6766292 1 NC_003155.4 hypothetical protein 6766292 1216120 SAV_5592 Streptomyces avermitilis MA-4680 hypothetical protein NP_826769.1 6765261 D 227882 CDS NP_826770.1 29832136 1211311 complement(6766171..6766509) 1 NC_003155.4 regulatory protein for glutamine synthetase; glnB-homolog; nitrogen regulatory protein P-II 6766509 glnB2 1211311 glnB2 Streptomyces avermitilis MA-4680 nitrogen regulatory protein P-II NP_826770.1 6766171 R 227882 CDS NP_826771.1 29832137 1211312 complement(6766506..6767816) 1 NC_003155.4 ammonium transporter 6767816 amtB2 1211312 amtB2 Streptomyces avermitilis MA-4680 ammonium transporter NP_826771.1 6766506 R 227882 CDS NP_826772.1 29832138 1211313 6767983..6768975 1 NC_003155.4 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 6768975 era 1211313 era Streptomyces avermitilis MA-4680 GTP-binding protein Era NP_826772.1 6767983 D 227882 CDS NP_826773.1 29832139 1216121 complement(6769041..6769886) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 6769886 1216121 SAV_5596 Streptomyces avermitilis MA-4680 acetyltransferase NP_826773.1 6769041 R 227882 CDS NP_826774.1 29832140 1216122 complement(6769929..6771194) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; hypothetical protein 6771194 1216122 SAV_5597 Streptomyces avermitilis MA-4680 hypothetical protein NP_826774.1 6769929 R 227882 CDS NP_826775.1 29832141 1211314 complement(6771191..6772516) 1 NC_003155.4 beta-glucosidase 6772516 bglC3 1211314 bglC3 Streptomyces avermitilis MA-4680 beta-glucosidase NP_826775.1 6771191 R 227882 CDS NP_826776.1 29832142 1216123 complement(6772563..6772829) 1 NC_003155.4 hypothetical protein 6772829 1216123 SAV_5599 Streptomyces avermitilis MA-4680 hypothetical protein NP_826776.1 6772563 R 227882 CDS NP_826777.1 29832143 1216124 complement(6772883..6773953) 1 NC_003155.4 PF02868: Thermolysin metallopeptidase, alpha-helical domain; metalloprotease 6773953 1216124 SAV_5600 Streptomyces avermitilis MA-4680 metalloprotease NP_826777.1 6772883 R 227882 CDS NP_826778.2 161511221 1211315 6774355..6776049 1 NC_003155.4 2-isopropylmalate synthase 6776049 leuA2 1211315 leuA2 Streptomyces avermitilis MA-4680 2-isopropylmalate synthase NP_826778.2 6774355 D 227882 CDS NP_826779.1 29832145 1216125 6776234..6776959 1 NC_003155.4 hypothetical protein 6776959 1216125 SAV_5602 Streptomyces avermitilis MA-4680 hypothetical protein NP_826779.1 6776234 D 227882 CDS NP_826780.1 29832146 1216126 6777171..6779249 1 NC_003155.4 PF03176: MMPL family; hypothetical protein 6779249 1216126 SAV_5603 Streptomyces avermitilis MA-4680 hypothetical protein NP_826780.1 6777171 D 227882 CDS NP_826781.1 29832147 1216127 6779296..6780648 1 NC_003155.4 two-component system sensor kinase 6780648 1216127 SAV_5604 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_826781.1 6779296 D 227882 CDS NP_826782.1 29832148 1216128 6780660..6781343 1 NC_003155.4 two-component system response regulator 6781343 1216128 SAV_5605 Streptomyces avermitilis MA-4680 two-component system response regulator NP_826782.1 6780660 D 227882 CDS NP_826783.1 29832149 1216129 6781453..6782664 1 NC_003155.4 neuramidase 6782664 1216129 SAV_5606 Streptomyces avermitilis MA-4680 neuramidase NP_826783.1 6781453 D 227882 CDS NP_826784.1 29832150 1211316 complement(6782695..6783630) 1 NC_003155.4 dihydrodipicolinate synthase 6783630 dapA4 1211316 dapA4 Streptomyces avermitilis MA-4680 dihydrodipicolinate synthase NP_826784.1 6782695 R 227882 CDS NP_826785.1 29832151 1216130 complement(6783627..6784694) 1 NC_003155.4 ABC transporter ATP-binding protein 6784694 1216130 SAV_5608 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_826785.1 6783627 R 227882 CDS NP_826786.1 29832152 1216131 complement(6784691..6786649) 1 NC_003155.4 ABC transporter permease 6786649 1216131 SAV_5609 Streptomyces avermitilis MA-4680 ABC transporter permease NP_826786.1 6784691 R 227882 CDS NP_826787.1 29832153 1216132 complement(6786646..6787608) 1 NC_003155.4 ABC transporter permease 6787608 1216132 SAV_5610 Streptomyces avermitilis MA-4680 ABC transporter permease NP_826787.1 6786646 R 227882 CDS NP_826788.1 29832154 1216133 complement(6787628..6789259) 1 NC_003155.4 ABC transporter substrate-binding protein 6789259 1216133 SAV_5611 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_826788.1 6787628 R 227882 CDS NP_826789.1 29832155 1216134 6789482..6790195 1 NC_003155.4 GntR family transcriptional regulator 6790195 1216134 SAV_5612 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_826789.1 6789482 D 227882 CDS NP_826790.1 29832156 1216135 6790221..6790655 1 NC_003155.4 hypothetical protein 6790655 1216135 SAV_5613 Streptomyces avermitilis MA-4680 hypothetical protein NP_826790.1 6790221 D 227882 CDS NP_826791.1 29832157 1216136 complement(6790707..6792146) 1 NC_003155.4 efflux protein 6792146 1216136 SAV_5614 Streptomyces avermitilis MA-4680 efflux protein NP_826791.1 6790707 R 227882 CDS NP_826792.1 29832158 1216137 complement(6792152..6793180) 1 NC_003155.4 cysteine synthase (O-acetylserine sulfhydylase) 6793180 1216137 SAV_5615 Streptomyces avermitilis MA-4680 cysteine synthase (O-acetylserine sulfhydylase) NP_826792.1 6792152 R 227882 CDS NP_826793.1 29832159 1216138 complement(6793223..6794596) 1 NC_003155.4 amino acid decarboxylase 6794596 1216138 SAV_5616 Streptomyces avermitilis MA-4680 amino acid decarboxylase NP_826793.1 6793223 R 227882 CDS NP_826794.1 29832160 1211317 complement(6794587..6795618) 1 NC_003155.4 ornithine cyclodeaminase 6795618 arcB3 1211317 arcB3 Streptomyces avermitilis MA-4680 ornithine cyclodeaminase NP_826794.1 6794587 R 227882 CDS NP_826795.1 29832161 1216139 complement(6795641..6796633) 1 NC_003155.4 oxygenase 6796633 1216139 SAV_5618 Streptomyces avermitilis MA-4680 oxygenase NP_826795.1 6795641 R 227882 CDS NP_826796.1 29832162 1216140 6797004..6798554 1 NC_003155.4 ABC transporter substrate-binding protein 6798554 1216140 SAV_5619 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_826796.1 6797004 D 227882 CDS NP_826797.1 29832163 1216141 6798668..6799558 1 NC_003155.4 ABC transporter permease 6799558 1216141 SAV_5620 Streptomyces avermitilis MA-4680 ABC transporter permease NP_826797.1 6798668 D 227882 CDS NP_826798.1 29832164 1216142 6799555..6800403 1 NC_003155.4 ABC transporter permease 6800403 1216142 SAV_5621 Streptomyces avermitilis MA-4680 ABC transporter permease NP_826798.1 6799555 D 227882 CDS NP_826799.1 29832165 1216143 6800400..6801986 1 NC_003155.4 ABC transporter ATP-binding protein 6801986 1216143 SAV_5622 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_826799.1 6800400 D 227882 CDS NP_826800.1 29832166 1216144 6802201..6803397 1 NC_003155.4 two-component system sensor kinase 6803397 1216144 SAV_5623 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_826800.1 6802201 D 227882 CDS NP_826801.1 29832167 1216145 6803394..6804113 1 NC_003155.4 two-component system response regulator 6804113 1216145 SAV_5624 Streptomyces avermitilis MA-4680 two-component system response regulator NP_826801.1 6803394 D 227882 CDS NP_826802.1 29832168 1216146 complement(6804091..6804363) 1 NC_003155.4 PF04149: Domain of unknown function (DUF397); hypothetical protein 6804363 1216146 SAV_5625 Streptomyces avermitilis MA-4680 hypothetical protein NP_826802.1 6804091 R 227882 CDS NP_826803.1 29832169 1216147 complement(6804345..6805178) 1 NC_003155.4 DNA-binding protein 6805178 1216147 SAV_5626 Streptomyces avermitilis MA-4680 DNA-binding protein NP_826803.1 6804345 R 227882 CDS NP_826804.1 29832170 1216148 6805580..6805807 1 NC_003155.4 hypothetical protein 6805807 1216148 SAV_5627 Streptomyces avermitilis MA-4680 hypothetical protein NP_826804.1 6805580 D 227882 CDS NP_826805.2 161511220 1216149 6805880..6806626 1 NC_003155.4 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 6806626 recO 1216149 recO Streptomyces avermitilis MA-4680 DNA repair protein RecO NP_826805.2 6805880 D 227882 CDS NP_826806.1 29832172 1211318 6806695..6807552 1 NC_003155.4 UDP diphosphate synthase 6807552 uppS2 1211318 uppS2 Streptomyces avermitilis MA-4680 UDP diphosphate synthase NP_826806.1 6806695 D 227882 CDS NP_826807.1 29832173 1216150 complement(6807623..6810019) 1 NC_003155.4 PF02868: Thermolysin metallopeptidase, alpha-helical domain; neutral zinc metalloprotease 6810019 1216150 SAV_5630 Streptomyces avermitilis MA-4680 neutral zinc metalloprotease NP_826807.1 6807623 R 227882 CDS NP_826808.1 29832174 1216151 complement(6810583..6810999) 1 NC_003155.4 metal uptake regulation protein 6810999 1216151 SAV_5631 Streptomyces avermitilis MA-4680 metal uptake regulation protein NP_826808.1 6810583 R 227882 CDS NP_826809.1 29832175 1216152 complement(6811058..6811954) 1 NC_003155.4 metal transport system ABC transporter permease 6811954 1216152 SAV_5632 Streptomyces avermitilis MA-4680 metal transport system ABC transporter permease NP_826809.1 6811058 R 227882 CDS NP_826810.1 29832176 1211319 complement(6811954..6812766) 1 NC_003155.4 manganese/zinc transport system ABC transporter ATP-binding protein 6812766 mntB 1211319 mntB Streptomyces avermitilis MA-4680 manganese/zinc transport system ABC transporter ATP-binding protein NP_826810.1 6811954 R 227882 CDS NP_826811.1 29832177 1216153 complement(6812784..6813746) 1 NC_003155.4 metal transport system ABC transporter substrate-binding protein 6813746 1216153 SAV_5634 Streptomyces avermitilis MA-4680 metal transport system ABC transporter substrate-binding protein NP_826811.1 6812784 R 227882 CDS NP_826812.1 29832178 1211320 6813890..6815272 1 NC_003155.4 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase 6815272 glyS 1211320 glyS Streptomyces avermitilis MA-4680 glycyl-tRNA synthetase NP_826812.1 6813890 D 227882 CDS NP_826813.1 29832179 1216154 complement(6815383..6816435) 1 NC_003155.4 endochitinase 6816435 1216154 SAV_5636 Streptomyces avermitilis MA-4680 endochitinase NP_826813.1 6815383 R 227882 CDS NP_826814.1 29832180 1216155 6816672..6817688 1 NC_003155.4 PF00248: Aldo/keto reductase family; oxidoreductase 6817688 1216155 SAV_5637 Streptomyces avermitilis MA-4680 oxidoreductase NP_826814.1 6816672 D 227882 CDS NP_826815.1 29832181 1216156 6817715..6818302 1 NC_003155.4 TetR family transcriptional regulator 6818302 1216156 SAV_5638 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_826815.1 6817715 D 227882 CDS NP_826816.1 29832182 1216157 complement(6818362..6819186) 1 NC_003155.4 PF04672: Protein of unknown function (DUF574); hypothetical protein 6819186 1216157 SAV_5639 Streptomyces avermitilis MA-4680 hypothetical protein NP_826816.1 6818362 R 227882 CDS NP_826817.1 29832183 1216158 6819748..6820596 1 NC_003155.4 hypothetical protein 6820596 1216158 SAV_5640 Streptomyces avermitilis MA-4680 hypothetical protein NP_826817.1 6819748 D 227882 CDS NP_826818.1 29832184 1216159 6820847..6822631 1 NC_003155.4 hypothetical protein 6822631 1216159 SAV_5641 Streptomyces avermitilis MA-4680 hypothetical protein NP_826818.1 6820847 D 227882 CDS NP_826819.1 29832185 1216160 complement(6822797..6823252) 1 NC_003155.4 hypothetical protein 6823252 1216160 SAV_5642 Streptomyces avermitilis MA-4680 hypothetical protein NP_826819.1 6822797 R 227882 CDS NP_826820.1 29832186 1216161 complement(6823346..6823669) 1 NC_003155.4 hypothetical protein 6823669 1216161 SAV_5643 Streptomyces avermitilis MA-4680 hypothetical protein NP_826820.1 6823346 R 227882 CDS NP_826821.1 29832187 1216162 complement(6823727..6824236) 1 NC_003155.4 MarR family transcriptional regulator 6824236 1216162 SAV_5644 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_826821.1 6823727 R 227882 CDS NP_826822.1 29832188 1216163 6824343..6825134 1 NC_003155.4 FMNH2-utilizing oxygenase 6825134 1216163 SAV_5645 Streptomyces avermitilis MA-4680 FMNH2-utilizing oxygenase NP_826822.1 6824343 D 227882 CDS NP_826823.1 29832189 1216164 complement(6825131..6826558) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 6826558 1216164 SAV_5646 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_826823.1 6825131 R 227882 CDS NP_826824.1 29832190 1216165 6826717..6827619 1 NC_003155.4 DNA-binding protein 6827619 1216165 SAV_5647 Streptomyces avermitilis MA-4680 DNA-binding protein NP_826824.1 6826717 D 227882 CDS NP_826825.1 29832191 1216166 complement(6827627..6829072) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; efflux membrane protein 6829072 1216166 SAV_5648 Streptomyces avermitilis MA-4680 efflux membrane protein NP_826825.1 6827627 R 227882 CDS NP_826826.1 29832192 1216167 6829246..6830451 1 NC_003155.4 dihydrouridine synthase 6830451 dus 1216167 dus Streptomyces avermitilis MA-4680 dihydrouridine synthase NP_826826.1 6829246 D 227882 CDS NP_826827.1 29832193 1216168 complement(6830452..6832137) 1 NC_003155.4 PF00884: Sulfatase; hypothetical protein 6832137 1216168 SAV_5650 Streptomyces avermitilis MA-4680 hypothetical protein NP_826827.1 6830452 R 227882 CDS NP_826828.1 29832194 1216169 complement(6832512..6834455) 1 NC_003155.4 hypothetical protein 6834455 1216169 SAV_5651 Streptomyces avermitilis MA-4680 hypothetical protein NP_826828.1 6832512 R 227882 CDS NP_826829.1 29832195 1216170 complement(6834510..6836048) 1 NC_003155.4 PF06202: Amylo-alpha-1,6-glucosidase; hypothetical protein 6836048 1216170 SAV_5652 Streptomyces avermitilis MA-4680 hypothetical protein NP_826829.1 6834510 R 227882 CDS NP_826830.1 29832196 1216171 6836162..6837388 1 NC_003155.4 transcriptional regulator 6837388 1216171 SAV_5653 Streptomyces avermitilis MA-4680 transcriptional regulator NP_826830.1 6836162 D 227882 CDS NP_826831.1 29832197 1211321 6837828..6840578 1 NC_003155.4 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate phosphate dikinase 6840578 ppdK 1211321 ppdK Streptomyces avermitilis MA-4680 pyruvate phosphate dikinase NP_826831.1 6837828 D 227882 CDS NP_826832.1 29832198 1216172 complement(6840721..6842214) 1 NC_003155.4 two-component system sensor kinase 6842214 1216172 SAV_5655 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_826832.1 6840721 R 227882 CDS NP_826833.1 29832199 1216173 complement(6842211..6843059) 1 NC_003155.4 two-component system response regulator 6843059 1216173 SAV_5656 Streptomyces avermitilis MA-4680 two-component system response regulator NP_826833.1 6842211 R 227882 CDS NP_826834.1 29832200 1216174 6843298..6843903 1 NC_003155.4 carbonic anhydrase 6843903 cynT2 1216174 cynT2 Streptomyces avermitilis MA-4680 carbonic anhydrase NP_826834.1 6843298 D 227882 CDS NP_826835.1 29832201 1216175 6843900..6846017 1 NC_003155.4 PF00916: Sulfate transporter family; transmembrane sulfate transport protein 6846017 1216175 SAV_5658 Streptomyces avermitilis MA-4680 transmembrane sulfate transport protein NP_826835.1 6843900 D 227882 CDS NP_826836.1 29832202 1216176 6846056..6846982 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 6846982 1216176 SAV_5659 Streptomyces avermitilis MA-4680 dehydrogenase NP_826836.1 6846056 D 227882 CDS NP_826837.1 29832203 1211322 complement(6847070..6847420) 1 NC_003155.4 nitrite reductase (NAD(P)H) small subunit 6847420 nirD 1211322 nirD Streptomyces avermitilis MA-4680 nitrite reductase (NAD(P)H) small subunit NP_826837.1 6847070 R 227882 CDS NP_826838.1 29832204 1211323 complement(6847417..6850023) 1 NC_003155.4 nitrite reductase (NAD(P)H) large subunit 6850023 nirB 1211323 nirB Streptomyces avermitilis MA-4680 nitrite reductase (NAD(P)H) large subunit NP_826838.1 6847417 R 227882 CDS NP_826839.1 29832205 1216177 6850413..6851195 1 NC_003155.4 PF01925: Domain of unknown function DUF81; hypothetical protein 6851195 1216177 SAV_5662 Streptomyces avermitilis MA-4680 hypothetical protein NP_826839.1 6850413 D 227882 CDS NP_826840.1 29832206 1216178 complement(6851297..6851917) 1 NC_003155.4 PF04203: sortase family; protein 6851917 1216178 SAV_5663 Streptomyces avermitilis MA-4680 protein NP_826840.1 6851297 R 227882 CDS NP_826841.1 29832207 1216179 complement(6852035..6852544) 1 NC_003155.4 hypothetical protein 6852544 1216179 SAV_5664 Streptomyces avermitilis MA-4680 hypothetical protein NP_826841.1 6852035 R 227882 CDS NP_826842.1 29832208 1216180 6852929..6853573 1 NC_003155.4 reductase 6853573 1216180 SAV_5665 Streptomyces avermitilis MA-4680 reductase NP_826842.1 6852929 D 227882 CDS NP_826843.1 29832209 1216181 complement(6853604..6854281) 1 NC_003155.4 PF04264: YceI like family; hypothetical protein 6854281 1216181 SAV_5666 Streptomyces avermitilis MA-4680 hypothetical protein NP_826843.1 6853604 R 227882 CDS NP_826844.1 29832210 1216182 complement(6854626..6855048) 1 NC_003155.4 MarR family transcriptional regulator 6855048 1216182 SAV_5667 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_826844.1 6854626 R 227882 CDS NP_826845.1 29832211 1216183 6855110..6855859 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 6855859 1216183 SAV_5668 Streptomyces avermitilis MA-4680 hydrolase NP_826845.1 6855110 D 227882 CDS NP_826846.1 29832212 1211324 complement(6855957..6857552) 1 NC_003155.4 PF02868: Thermolysin metallopeptidase, alpha-helical domain; neutral zinc metalloprotease 6857552 1211324 SAV_5669 Streptomyces avermitilis MA-4680 neutral zinc metalloprotease NP_826846.1 6855957 R 227882 CDS NP_826847.1 29832213 1216184 6857841..6858284 1 NC_003155.4 PF03674: Uncharacterised protein family (UPF0131); hypothetical protein 6858284 1216184 SAV_5670 Streptomyces avermitilis MA-4680 hypothetical protein NP_826847.1 6857841 D 227882 CDS NP_826848.1 29832214 1216185 6858335..6859426 1 NC_003155.4 PF00775: Dioxygenase; protocatechuate dioxygenase 6859426 1216185 SAV_5671 Streptomyces avermitilis MA-4680 protocatechuate dioxygenase NP_826848.1 6858335 D 227882 CDS NP_826849.1 29832215 1216186 complement(6859503..6860195) 1 NC_003155.4 probable vancomycin sensitivity, PF02698: DUF218 domain; integral membrane protein 6860195 1216186 SAV_5672 Streptomyces avermitilis MA-4680 integral membrane protein NP_826849.1 6859503 R 227882 CDS NP_826850.1 29832216 1216187 6860373..6861293 1 NC_003155.4 PF01903: CbiX; hypothetical protein 6861293 1216187 SAV_5673 Streptomyces avermitilis MA-4680 hypothetical protein NP_826850.1 6860373 D 227882 CDS NP_826851.1 29832217 1211325 6861343..6862695 1 NC_003155.4 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase-like protein 6862695 dgt 1211325 dgt Streptomyces avermitilis MA-4680 deoxyguanosinetriphosphate triphosphohydrolase-like protein NP_826851.1 6861343 D 227882 CDS NP_826852.1 29832218 1211326 6862850..6864115 1 NC_003155.4 ferredoxin reductase 6864115 fprD 1211326 fprD Streptomyces avermitilis MA-4680 ferredoxin reductase NP_826852.1 6862850 D 227882 CDS NP_826853.1 29832219 1211327 6864460..6866358 1 NC_003155.4 synthesizes RNA primers at the replication forks; DNA primase 6866358 dnaG 1211327 dnaG Streptomyces avermitilis MA-4680 DNA primase NP_826853.1 6864460 D 227882 CDS NP_826854.1 29832220 1216188 complement(6866371..6867369) 1 NC_003155.4 hypothetical protein 6867369 1216188 SAV_5677 Streptomyces avermitilis MA-4680 hypothetical protein NP_826854.1 6866371 R 227882 CDS NP_826855.1 29832221 1216189 complement(6867366..6868019) 1 NC_003155.4 hypothetical protein 6868019 1216189 SAV_5678 Streptomyces avermitilis MA-4680 hypothetical protein NP_826855.1 6867366 R 227882 CDS NP_826856.1 29832222 1211328 6868347..6869516 1 NC_003155.4 sigma-70 family; RNA polymerase sigma factor 6869516 sig47 1211328 sig47 Streptomyces avermitilis MA-4680 RNA polymerase sigma factor NP_826856.1 6868347 D 227882 CDS NP_826857.1 29832223 1216190 complement(6869556..6871484) 1 NC_003155.4 ABC transporter ATP-binding protein 6871484 1216190 SAV_5680 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_826857.1 6869556 R 227882 CDS NP_826858.1 29832224 1216191 complement(6871484..6873217) 1 NC_003155.4 ABC transporter ATP-binding protein 6873217 1216191 SAV_5681 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_826858.1 6871484 R 227882 CDS NP_826859.1 29832225 1216192 complement(6873380..6873712) 1 NC_003155.4 hypothetical protein 6873712 1216192 SAV_5682 Streptomyces avermitilis MA-4680 hypothetical protein NP_826859.1 6873380 R 227882 CDS NP_826860.1 29832226 1216193 complement(6873734..6874831) 1 NC_003155.4 xylulose kinase 6874831 xylB3 1216193 xylB3 Streptomyces avermitilis MA-4680 xylulose kinase NP_826860.1 6873734 R 227882 CDS NP_826861.1 29832227 1216194 complement(6875107..6875421) 1 NC_003155.4 hypothetical protein 6875421 1216194 SAV_5684 Streptomyces avermitilis MA-4680 hypothetical protein NP_826861.1 6875107 R 227882 CDS NP_826862.1 29832228 1216195 complement(6876741..6877157) 1 NC_003155.4 transposase 6877157 1216195 SAV_5685 Streptomyces avermitilis MA-4680 transposase NP_826862.1 6876741 R 227882 CDS NP_826863.1 29832229 1216196 complement(6877533..6879374) 1 NC_003155.4 ABC transporter ATP-binding protein 6879374 1216196 SAV_5686 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_826863.1 6877533 R 227882 CDS NP_826864.1 29832230 1216197 complement(6879386..6879820) 1 NC_003155.4 hypothetical protein 6879820 1216197 SAV_5687 Streptomyces avermitilis MA-4680 hypothetical protein NP_826864.1 6879386 R 227882 CDS NP_826865.1 29832231 1216198 complement(6879817..6880104) 1 NC_003155.4 hypothetical protein 6880104 1216198 SAV_5688 Streptomyces avermitilis MA-4680 hypothetical protein NP_826865.1 6879817 R 227882 CDS NP_826866.1 29832232 1216199 complement(6880101..6881873) 1 NC_003155.4 asparagine synthetase 6881873 asnH2 1216199 asnH2 Streptomyces avermitilis MA-4680 asparagine synthetase NP_826866.1 6880101 R 227882 CDS NP_826867.1 29832233 1216200 complement(6882750..6883307) 1 NC_003155.4 hypothetical protein 6883307 1216200 SAV_5690 Streptomyces avermitilis MA-4680 hypothetical protein NP_826867.1 6882750 R 227882 CDS NP_826868.1 29832234 1216201 complement(6883337..6883585) 1 NC_003155.4 hypothetical protein 6883585 1216201 SAV_5691 Streptomyces avermitilis MA-4680 hypothetical protein NP_826868.1 6883337 R 227882 CDS NP_826869.1 29832235 1216202 complement(6883615..6883887) 1 NC_003155.4 hypothetical protein 6883887 1216202 SAV_5692 Streptomyces avermitilis MA-4680 hypothetical protein NP_826869.1 6883615 R 227882 CDS NP_826870.1 29832236 1216203 6884073..6884306 1 NC_003155.4 hypothetical protein 6884306 1216203 SAV_5693 Streptomyces avermitilis MA-4680 hypothetical protein NP_826870.1 6884073 D 227882 CDS NP_826871.1 29832237 1216204 6884303..6884710 1 NC_003155.4 PF01850: PIN domain; hypothetical protein 6884710 1216204 SAV_5694 Streptomyces avermitilis MA-4680 hypothetical protein NP_826871.1 6884303 D 227882 CDS NP_826872.1 29832238 1216205 6885756..6887651 1 NC_003155.4 PF00350: Dynamin family; hypothetical protein 6887651 1216205 SAV_5695 Streptomyces avermitilis MA-4680 hypothetical protein NP_826872.1 6885756 D 227882 CDS NP_826873.1 29832239 1216206 6887655..6889511 1 NC_003155.4 PF00350: Dynamin family; hypothetical protein 6889511 1216206 SAV_5696 Streptomyces avermitilis MA-4680 hypothetical protein NP_826873.1 6887655 D 227882 CDS NP_826874.1 29832240 1216207 6889508..6891487 1 NC_003155.4 hypothetical protein 6891487 1216207 SAV_5697 Streptomyces avermitilis MA-4680 hypothetical protein NP_826874.1 6889508 D 227882 CDS NP_826875.1 29832241 1216208 6891487..6892749 1 NC_003155.4 hypothetical protein 6892749 1216208 SAV_5698 Streptomyces avermitilis MA-4680 hypothetical protein NP_826875.1 6891487 D 227882 CDS NP_826876.1 29832242 1216209 6892750..6893244 1 NC_003155.4 hypothetical protein 6893244 1216209 SAV_5699 Streptomyces avermitilis MA-4680 hypothetical protein NP_826876.1 6892750 D 227882 CDS NP_826877.1 29832243 1216210 complement(6893160..6893864) 1 NC_003155.4 transcriptional regulator 6893864 1216210 SAV_5700 Streptomyces avermitilis MA-4680 transcriptional regulator NP_826877.1 6893160 R 227882 CDS NP_826878.1 29832244 1216211 complement(6894374..6895405) 1 NC_003155.4 LacI family transcriptional regulator 6895405 1216211 SAV_5701 Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_826878.1 6894374 R 227882 CDS NP_826879.1 29832245 1216212 complement(6895482..6896318) 1 NC_003155.4 ABC transporter ATP-binding protein 6896318 1216212 SAV_5702 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_826879.1 6895482 R 227882 CDS NP_826880.1 29832246 1216213 complement(6896315..6897310) 1 NC_003155.4 sugar ABC transporter permease 6897310 1216213 SAV_5703 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_826880.1 6896315 R 227882 CDS NP_826881.1 29832247 1216214 complement(6897466..6898488) 1 NC_003155.4 sugar ABC transporter substrate-binding protein 6898488 1216214 SAV_5704 Streptomyces avermitilis MA-4680 sugar ABC transporter substrate-binding protein NP_826881.1 6897466 R 227882 CDS NP_826882.1 29832248 1211332 6898796..6899758 1 NC_003155.4 fructokinase 6899758 scrK1 1211332 scrK1 Streptomyces avermitilis MA-4680 fructokinase NP_826882.1 6898796 D 227882 CDS NP_826883.1 29832249 1216215 6899853..6900146 1 NC_003155.4 PF03992: Antibiotic biosynthesis monooxygenase; hypothetical protein 6900146 1216215 SAV_5706 Streptomyces avermitilis MA-4680 hypothetical protein NP_826883.1 6899853 D 227882 CDS NP_826884.1 29832250 1216216 6900279..6900848 1 NC_003155.4 hypothetical protein 6900848 1216216 SAV_5707 Streptomyces avermitilis MA-4680 hypothetical protein NP_826884.1 6900279 D 227882 CDS NP_826885.1 29832251 1216217 complement(6901001..6901249) 1 NC_003155.4 hypothetical protein 6901249 1216217 SAV_5708 Streptomyces avermitilis MA-4680 hypothetical protein NP_826885.1 6901001 R 227882 CDS NP_826886.1 29832252 1216218 complement(6901246..6902580) 1 NC_003155.4 PF00082: Subtilase family; protease 6902580 1216218 SAV_5709 Streptomyces avermitilis MA-4680 protease NP_826886.1 6901246 R 227882 CDS NP_826887.1 29832253 1216219 complement(6902814..6903446) 1 NC_003155.4 PF00156: Phosphoribosyl transferase domain; hypothetical protein 6903446 1216219 SAV_5710 Streptomyces avermitilis MA-4680 hypothetical protein NP_826887.1 6902814 R 227882 CDS NP_826888.1 29832254 1216220 6903717..6904673 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 6904673 1216220 SAV_5711 Streptomyces avermitilis MA-4680 hydrolase NP_826888.1 6903717 D 227882 CDS NP_826889.1 29832255 1216221 complement(6904678..6908622) 1 NC_003155.4 ATP/GTP-binding protein 6908622 1216221 SAV_5712 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_826889.1 6904678 R 227882 CDS NP_826890.1 29832256 1216222 complement(6908619..6909953) 1 NC_003155.4 hypothetical protein 6909953 1216222 SAV_5713 Streptomyces avermitilis MA-4680 hypothetical protein NP_826890.1 6908619 R 227882 CDS NP_826891.1 29832257 1211333 complement(6910054..6910827) 1 NC_003155.4 aminoglycoside N3-acetyltransferase 6910827 aac2 1211333 aac2 Streptomyces avermitilis MA-4680 aminoglycoside N3-acetyltransferase NP_826891.1 6910054 R 227882 CDS NP_826892.1 29832258 1216223 complement(6910820..6912991) 1 NC_003155.4 PF04055: Radical SAM superfamily; hypothetical protein 6912991 1216223 SAV_5715 Streptomyces avermitilis MA-4680 hypothetical protein NP_826892.1 6910820 R 227882 CDS NP_826893.1 29832259 1216224 complement(6913090..6913272) 1 NC_003155.4 hypothetical protein 6913272 1216224 SAV_5716 Streptomyces avermitilis MA-4680 hypothetical protein NP_826893.1 6913090 R 227882 CDS NP_826894.1 29832260 1216225 6913513..6914433 1 NC_003155.4 hypothetical protein 6914433 1216225 SAV_5717 Streptomyces avermitilis MA-4680 hypothetical protein NP_826894.1 6913513 D 227882 CDS NP_826895.1 29832261 1216226 complement(6914454..6914930) 1 NC_003155.4 hypothetical protein 6914930 1216226 SAV_5718 Streptomyces avermitilis MA-4680 hypothetical protein NP_826895.1 6914454 R 227882 CDS NP_826896.1 29832262 1216227 complement(6915084..6916625) 1 NC_003155.4 two-component system sensor kinase 6916625 1216227 SAV_5719 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_826896.1 6915084 R 227882 CDS NP_826897.1 29832263 1211334 complement(6916653..6917690) 1 NC_003155.4 PF06723: MreB/Mbl protein; rod shape-determining protein MreB 6917690 mreB2 1211334 mreB2 Streptomyces avermitilis MA-4680 rod shape-determining protein MreB NP_826897.1 6916653 R 227882 CDS NP_826898.1 29832264 1216228 6918257..6921883 1 NC_003155.4 PF00082: Subtilase family; protease 6921883 1216228 SAV_5721 Streptomyces avermitilis MA-4680 protease NP_826898.1 6918257 D 227882 CDS NP_826899.1 29832265 1211335 complement(6921858..6923255) 1 NC_003155.4 acetyl CoA carboxylase beta subunit 6923255 accD3 1211335 accD3 Streptomyces avermitilis MA-4680 acetyl CoA carboxylase beta subunit NP_826899.1 6921858 R 227882 CDS NP_826900.1 29832266 1211336 complement(6923259..6924728) 1 NC_003155.4 activates fatty acids by binding to coenzyme A; acyl-CoA synthetase 6924728 fadD13 1211336 fadD13 Streptomyces avermitilis MA-4680 acyl-CoA synthetase NP_826900.1 6923259 R 227882 CDS NP_826901.1 29832267 1216229 complement(6924844..6925422) 1 NC_003155.4 TetR family transcriptional regulator 6925422 1216229 SAV_5724 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_826901.1 6924844 R 227882 CDS NP_826902.1 29832268 1216230 6925604..6925975 1 NC_003155.4 hypothetical protein 6925975 1216230 SAV_5725 Streptomyces avermitilis MA-4680 hypothetical protein NP_826902.1 6925604 D 227882 CDS NP_826903.1 29832269 1216231 6926010..6926501 1 NC_003155.4 PF00190: Cupin; hypothetical protein 6926501 1216231 SAV_5726 Streptomyces avermitilis MA-4680 hypothetical protein NP_826903.1 6926010 D 227882 CDS NP_826904.1 29832270 1216232 complement(6926536..6927681) 1 NC_003155.4 PF00376: MerR family regulatory protein, PF00481: Protein phosphatase 2C; magnesium or manganese-dependent protein phosphatase 6927681 prpH 1216232 prpH Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_826904.1 6926536 R 227882 CDS NP_826905.1 29832271 1216233 6927832..6928704 1 NC_003155.4 hypothetical protein 6928704 1216233 SAV_5728 Streptomyces avermitilis MA-4680 hypothetical protein NP_826905.1 6927832 D 227882 CDS NP_826906.1 29832272 1216234 complement(6928685..6929347) 1 NC_003155.4 hypothetical protein 6929347 1216234 SAV_5729 Streptomyces avermitilis MA-4680 hypothetical protein NP_826906.1 6928685 R 227882 CDS NP_826907.1 29832273 1216235 complement(6929295..6930134) 1 NC_003155.4 hypothetical protein 6930134 1216235 SAV_5730 Streptomyces avermitilis MA-4680 hypothetical protein NP_826907.1 6929295 R 227882 CDS NP_826908.1 29832274 1216236 complement(6930131..6930352) 1 NC_003155.4 PF03966: Protein of unknown function (DUF343); hypothetical protein 6930352 1216236 SAV_5731 Streptomyces avermitilis MA-4680 hypothetical protein NP_826908.1 6930131 R 227882 CDS NP_826909.1 29832275 1216237 complement(6930349..6931269) 1 NC_003155.4 hypothetical protein 6931269 1216237 SAV_5732 Streptomyces avermitilis MA-4680 hypothetical protein NP_826909.1 6930349 R 227882 CDS NP_826910.1 29832276 1216238 complement(6931273..6932007) 1 NC_003155.4 PF05401: Nodulation protein S (NodS); hypothetical protein 6932007 1216238 SAV_5733 Streptomyces avermitilis MA-4680 hypothetical protein NP_826910.1 6931273 R 227882 CDS NP_826911.1 29832277 1216239 complement(6932004..6933329) 1 NC_003155.4 PF00668: Condensation domain; hypothetical protein 6933329 1216239 SAV_5734 Streptomyces avermitilis MA-4680 hypothetical protein NP_826911.1 6932004 R 227882 CDS NP_826912.1 29832278 1216240 complement(6933326..6937870) 1 NC_003155.4 PF00754: F5/8 type C domain; hypothetical protein 6937870 1216240 SAV_5735 Streptomyces avermitilis MA-4680 hypothetical protein NP_826912.1 6933326 R 227882 CDS NP_826913.1 29832279 1216241 complement(6937867..6938592) 1 NC_003155.4 hypothetical protein 6938592 1216241 SAV_5736 Streptomyces avermitilis MA-4680 hypothetical protein NP_826913.1 6937867 R 227882 CDS NP_826914.1 29832280 1216242 complement(6938589..6939824) 1 NC_003155.4 PF00534: Glycosyl transferases group 1; glycosyl transferase 6939824 1216242 SAV_5737 Streptomyces avermitilis MA-4680 glycosyl transferase NP_826914.1 6938589 R 227882 CDS NP_826915.1 29832281 1216243 complement(6940049..6941026) 1 NC_003155.4 hypothetical protein 6941026 1216243 SAV_5738 Streptomyces avermitilis MA-4680 hypothetical protein NP_826915.1 6940049 R 227882 CDS NP_826916.1 29832282 1216244 6941273..6941461 1 NC_003155.4 hypothetical protein 6941461 1216244 SAV_5739 Streptomyces avermitilis MA-4680 hypothetical protein NP_826916.1 6941273 D 227882 CDS NP_826917.1 29832283 1216245 6941505..6942746 1 NC_003155.4 regulatory protein 6942746 1216245 SAV_5740 Streptomyces avermitilis MA-4680 regulatory protein NP_826917.1 6941505 D 227882 CDS NP_826918.1 29832284 1216246 6942974..6943747 1 NC_003155.4 IclR family transcriptional regulator 6943747 1216246 SAV_5741 Streptomyces avermitilis MA-4680 IclR family transcriptional regulator NP_826918.1 6942974 D 227882 CDS NP_826919.1 29832285 1216247 6943744..6944604 1 NC_003155.4 calcium-binding protein 6944604 1216247 SAV_5742 Streptomyces avermitilis MA-4680 calcium-binding protein NP_826919.1 6943744 D 227882 CDS NP_826920.1 29832286 1211337 6944863..6946374 1 NC_003155.4 alpha-L-arabinofuranosidase 6946374 abfA 1211337 abfA Streptomyces avermitilis MA-4680 alpha-L-arabinofuranosidase NP_826920.1 6944863 D 227882 CDS NP_826921.1 29832287 1216248 complement(6946518..6948203) 1 NC_003155.4 PF01833: IPT/TIG domain; hypothetical protein 6948203 1216248 SAV_5744 Streptomyces avermitilis MA-4680 hypothetical protein NP_826921.1 6946518 R 227882 CDS NP_826922.1 29832288 1216249 complement(6948381..6948731) 1 NC_003155.4 hypothetical protein 6948731 1216249 SAV_5745 Streptomyces avermitilis MA-4680 hypothetical protein NP_826922.1 6948381 R 227882 CDS NP_826923.1 29832289 1216250 6948850..6950259 1 NC_003155.4 two-component system sensor kinase 6950259 1216250 SAV_5746 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_826923.1 6948850 D 227882 CDS NP_826924.1 29832290 1216251 6950247..6950894 1 NC_003155.4 two-component system response regulator 6950894 1216251 SAV_5747 Streptomyces avermitilis MA-4680 two-component system response regulator NP_826924.1 6950247 D 227882 CDS NP_826925.1 29832291 1216252 6950891..6951697 1 NC_003155.4 lipoprotein 6951697 1216252 SAV_5748 Streptomyces avermitilis MA-4680 lipoprotein NP_826925.1 6950891 D 227882 CDS NP_826926.1 29832292 1216253 complement(6951786..6952241) 1 NC_003155.4 hypothetical protein 6952241 1216253 SAV_5749 Streptomyces avermitilis MA-4680 hypothetical protein NP_826926.1 6951786 R 227882 CDS NP_826927.1 29832293 1216254 complement(6952272..6952784) 1 NC_003155.4 hypothetical protein 6952784 1216254 SAV_5750 Streptomyces avermitilis MA-4680 hypothetical protein NP_826927.1 6952272 R 227882 CDS NP_826928.1 29832294 1216255 6953421..6955928 1 NC_003155.4 hypothetical protein 6955928 1216255 SAV_5751 Streptomyces avermitilis MA-4680 hypothetical protein NP_826928.1 6953421 D 227882 CDS NP_826929.1 29832295 1216256 6956080..6956331 1 NC_003155.4 hypothetical protein 6956331 1216256 SAV_5752 Streptomyces avermitilis MA-4680 hypothetical protein NP_826929.1 6956080 D 227882 CDS NP_826930.1 29832296 1216257 complement(6956717..6956959) 1 NC_003155.4 PF04149: Domain of unknown function (DUF397); hypothetical protein 6956959 1216257 SAV_5753 Streptomyces avermitilis MA-4680 hypothetical protein NP_826930.1 6956717 R 227882 CDS NP_826931.1 29832297 1216258 complement(6956956..6957798) 1 NC_003155.4 DNA-binding protein 6957798 1216258 SAV_5754 Streptomyces avermitilis MA-4680 DNA-binding protein NP_826931.1 6956956 R 227882 CDS NP_826932.1 29832298 1216259 6957927..6958385 1 NC_003155.4 regulatory protein 6958385 1216259 SAV_5755 Streptomyces avermitilis MA-4680 regulatory protein NP_826932.1 6957927 D 227882 CDS NP_826933.1 29832299 1211338 complement(6958393..6961323) 1 NC_003155.4 beta-galactosidase 6961323 bga7 1211338 bga7 Streptomyces avermitilis MA-4680 beta-galactosidase NP_826933.1 6958393 R 227882 CDS NP_826934.1 29832300 1216260 6961466..6961924 1 NC_003155.4 transcriptional regulator 6961924 1216260 SAV_5757 Streptomyces avermitilis MA-4680 transcriptional regulator NP_826934.1 6961466 D 227882 CDS NP_826935.1 29832301 1216261 complement(6962101..6962970) 1 NC_003155.4 PF00775: Dioxygenase; protocatechuate dioxygenase 6962970 1216261 SAV_5758 Streptomyces avermitilis MA-4680 protocatechuate dioxygenase NP_826935.1 6962101 R 227882 CDS NP_826936.1 29832302 1216262 complement(6963098..6964288) 1 NC_003155.4 PF01360: Monooxygenase; monooxygenase 6964288 1216262 SAV_5759 Streptomyces avermitilis MA-4680 monooxygenase NP_826936.1 6963098 R 227882 CDS NP_826937.1 29832303 1216263 complement(6964312..6965106) 1 NC_003155.4 TetR family transcriptional regulator 6965106 1216263 SAV_5760 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_826937.1 6964312 R 227882 CDS NP_826938.1 29832304 1216264 complement(6965288..6966052) 1 NC_003155.4 PF00775: Dioxygenase; protocatechuate dioxygenase 6966052 1216264 SAV_5761 Streptomyces avermitilis MA-4680 protocatechuate dioxygenase NP_826938.1 6965288 R 227882 CDS NP_826939.1 29832305 1216265 6966932..6967120 1 NC_003155.4 hypothetical protein 6967120 1216265 SAV_5762 Streptomyces avermitilis MA-4680 hypothetical protein NP_826939.1 6966932 D 227882 CDS NP_826940.1 29832306 1216266 6967178..6967900 1 NC_003155.4 ABC transporter ATP-binding protein 6967900 1216266 SAV_5763 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_826940.1 6967178 D 227882 CDS NP_826941.1 29832307 1216267 6968103..6968936 1 NC_003155.4 PF00144: Beta-lactamase; beta-lactamase 6968936 blaA4 1216267 blaA4 Streptomyces avermitilis MA-4680 beta-lactamase NP_826941.1 6968103 D 227882 CDS NP_826942.1 29832308 1216268 complement(6969006..6970655) 1 NC_003155.4 aminotransferase 6970655 1216268 SAV_5765 Streptomyces avermitilis MA-4680 aminotransferase NP_826942.1 6969006 R 227882 CDS NP_826943.1 29832309 1211339 complement(6970843..6971994) 1 NC_003155.4 aldose 1-epimerase 6971994 galM1 1211339 galM1 Streptomyces avermitilis MA-4680 aldose 1-epimerase NP_826943.1 6970843 R 227882 CDS NP_826944.1 29832310 1216269 complement(6972051..6973295) 1 NC_003155.4 sugar ABC transporter transport permease 6973295 1216269 SAV_5767 Streptomyces avermitilis MA-4680 sugar ABC transporter transport permease NP_826944.1 6972051 R 227882 CDS NP_826945.1 29832311 1216270 complement(6973301..6974842) 1 NC_003155.4 sugar ABC transporter ATP-binding protein 6974842 1216270 SAV_5768 Streptomyces avermitilis MA-4680 sugar ABC transporter ATP-binding protein NP_826945.1 6973301 R 227882 CDS NP_826946.1 29832312 1216271 complement(6974886..6975998) 1 NC_003155.4 sugar sugar ABC transporter substrate-binding protein 6975998 1216271 SAV_5769 Streptomyces avermitilis MA-4680 sugar sugar ABC transporter substrate-binding protein NP_826946.1 6974886 R 227882 CDS NP_826947.1 29832313 1216272 complement(6976141..6977109) 1 NC_003155.4 hypothetical protein 6977109 1216272 SAV_5770 Streptomyces avermitilis MA-4680 hypothetical protein NP_826947.1 6976141 R 227882 CDS NP_826948.1 29832314 1216273 complement(6977202..6978206) 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; alcohol dehydrogenase 6978206 adhA7 1216273 adhA7 Streptomyces avermitilis MA-4680 alcohol dehydrogenase NP_826948.1 6977202 R 227882 CDS NP_826949.1 29832315 1216274 complement(6978203..6979360) 1 NC_003155.4 dehydratase 6979360 1216274 SAV_5772 Streptomyces avermitilis MA-4680 dehydratase NP_826949.1 6978203 R 227882 CDS NP_826950.1 29832316 1216275 6979650..6980393 1 NC_003155.4 hypothetical protein 6980393 1216275 SAV_5773 Streptomyces avermitilis MA-4680 hypothetical protein NP_826950.1 6979650 D 227882 CDS NP_826951.1 29832317 1216276 complement(6980613..6981416) 1 NC_003155.4 hypothetical protein 6981416 1216276 SAV_5774 Streptomyces avermitilis MA-4680 hypothetical protein NP_826951.1 6980613 R 227882 CDS NP_826952.1 29832318 1216277 complement(6981481..6981912) 1 NC_003155.4 MarR family transcriptional regulator 6981912 1216277 SAV_5775 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_826952.1 6981481 R 227882 CDS NP_826953.1 29832319 1216278 6982063..6983085 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 6983085 1216278 SAV_5776 Streptomyces avermitilis MA-4680 dehydrogenase NP_826953.1 6982063 D 227882 CDS NP_826954.1 29832320 1216279 complement(6983345..6983533) 1 NC_003155.4 esterase 6983533 1216279 SAV_5777 Streptomyces avermitilis MA-4680 esterase NP_826954.1 6983345 R 227882 CDS NP_826955.1 29832321 1216280 complement(6983557..6983796) 1 NC_003155.4 esterase 6983796 1216280 SAV_5778 Streptomyces avermitilis MA-4680 esterase NP_826955.1 6983557 R 227882 CDS NP_826956.1 29832322 1216281 6984012..6984974 1 NC_003155.4 hypothetical protein 6984974 1216281 SAV_5779 Streptomyces avermitilis MA-4680 hypothetical protein NP_826956.1 6984012 D 227882 CDS NP_826957.1 29832323 1216282 6985071..6985787 1 NC_003155.4 PF04401: Protein of unknown function (DUF540); integral membrane protein 6985787 1216282 SAV_5780 Streptomyces avermitilis MA-4680 integral membrane protein NP_826957.1 6985071 D 227882 CDS NP_826958.1 29832324 1216283 complement(6985862..6987193) 1 NC_003155.4 PF01470: Pyroglutamyl peptidase; hypothetical protein 6987193 1216283 SAV_5781 Streptomyces avermitilis MA-4680 hypothetical protein NP_826958.1 6985862 R 227882 CDS NP_826959.1 29832325 1211340 complement(6987491..6988471) 1 NC_003155.4 aldose 1-epimerase 6988471 galM2 1211340 galM2 Streptomyces avermitilis MA-4680 aldose 1-epimerase NP_826959.1 6987491 R 227882 CDS NP_826960.1 29832326 1216284 complement(6988499..6989401) 1 NC_003155.4 PF00657: GDSL-like Lipase/Acylhydrolase; lipoprotein 6989401 1216284 SAV_5783 Streptomyces avermitilis MA-4680 lipoprotein NP_826960.1 6988499 R 227882 CDS NP_826961.1 29832327 1216285 6989596..6990090 1 NC_003155.4 hypothetical protein 6990090 1216285 SAV_5784 Streptomyces avermitilis MA-4680 hypothetical protein NP_826961.1 6989596 D 227882 CDS NP_826962.1 29832328 1211341 complement(6990166..6991437) 1 NC_003155.4 PF00109: Beta-ketoacyl synthase, N-terminal domain; 3-oxoacyl-ACP synthase II 6991437 fabB1 1211341 fabB1 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP synthase II NP_826962.1 6990166 R 227882 CDS NP_826963.1 29832329 1211342 complement(6991520..6991768) 1 NC_003155.4 carries the fatty acid chain in fatty acid biosynthesis; ACP 6991768 acpP 1211342 acpP Streptomyces avermitilis MA-4680 ACP NP_826963.1 6991520 R 227882 CDS NP_826964.1 29832330 1211343 complement(6991839..6992906) 1 NC_003155.4 FabH; beta-ketoacyl-ACP synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-ACP synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; in Pseudomonas this protein is involved in quinolone signal biosynthesis; 3-oxoacyl-ACP synthase III 6992906 fabH1 1211343 fabH1 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP synthase III NP_826964.1 6991839 R 227882 CDS NP_826965.1 29832331 1211344 complement(6992909..6993859) 1 NC_003155.4 PF00698: Acyl transferase domain; ACP S-malonyltransferase 6993859 fabD 1211344 fabD Streptomyces avermitilis MA-4680 ACP S-malonyltransferase NP_826965.1 6992909 R 227882 CDS NP_826966.1 29832332 1216286 complement(6993949..6995154) 1 NC_003155.4 hypothetical protein 6995154 1216286 SAV_5789 Streptomyces avermitilis MA-4680 hypothetical protein NP_826966.1 6993949 R 227882 CDS NP_826967.1 29832333 1216287 6995237..6995890 1 NC_003155.4 PF02678: Pirin; hypothetical protein 6995890 1216287 SAV_5790 Streptomyces avermitilis MA-4680 hypothetical protein NP_826967.1 6995237 D 227882 CDS NP_826968.1 29832334 1216288 complement(6995924..6996754) 1 NC_003155.4 PF00144: Beta-lactamase; beta-lactamase 6996754 blaA5 1216288 blaA5 Streptomyces avermitilis MA-4680 beta-lactamase NP_826968.1 6995924 R 227882 CDS NP_826969.1 29832335 1216289 6996911..6997393 1 NC_003155.4 MerR family transcriptional regulator 6997393 1216289 SAV_5792 Streptomyces avermitilis MA-4680 MerR family transcriptional regulator NP_826969.1 6996911 D 227882 CDS NP_826970.1 29832336 1216290 6997390..6998406 1 NC_003155.4 PF00248: Aldo/keto reductase family; oxidoreductase 6998406 1216290 SAV_5793 Streptomyces avermitilis MA-4680 oxidoreductase NP_826970.1 6997390 D 227882 CDS NP_826971.1 29832337 1216291 complement(6998454..6999317) 1 NC_003155.4 hypothetical protein 6999317 1216291 SAV_5794 Streptomyces avermitilis MA-4680 hypothetical protein NP_826971.1 6998454 R 227882 CDS NP_826972.1 29832338 1216292 complement(6999393..7000601) 1 NC_003155.4 PF06259: Domain of unknown function (DUF1023); protein 7000601 1216292 SAV_5795 Streptomyces avermitilis MA-4680 protein NP_826972.1 6999393 R 227882 CDS NP_826973.1 29832339 1216293 complement(7000776..7001456) 1 NC_003155.4 TetR family transcriptional regulator 7001456 1216293 SAV_5796 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_826973.1 7000776 R 227882 CDS NP_826974.1 29832340 1211345 7001572..7003194 1 NC_003155.4 PF07690: Major Facilitator Superfamily; tetracenomycin C resistance and export protein 7003194 tcmA 1211345 tcmA Streptomyces avermitilis MA-4680 tetracenomycin C resistance and export protein NP_826974.1 7001572 D 227882 CDS NP_826975.1 29832341 1216294 7003435..7003746 1 NC_003155.4 small hydrophobic protein 7003746 1216294 SAV_5798 Streptomyces avermitilis MA-4680 small hydrophobic protein NP_826975.1 7003435 D 227882 CDS NP_826976.1 29832342 1216295 complement(7003857..7004684) 1 NC_003155.4 PF00520: Ion transport protein; ion transport integral membrane protein 7004684 1216295 SAV_5799 Streptomyces avermitilis MA-4680 ion transport integral membrane protein NP_826976.1 7003857 R 227882 CDS NP_826977.1 29832343 1211346 complement(7004704..7007451) 1 NC_003155.4 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 7007451 aceE 1211346 aceE Streptomyces avermitilis MA-4680 pyruvate dehydrogenase subunit E1 NP_826977.1 7004704 R 227882 CDS NP_826978.1 29832344 1216296 7007846..7008325 1 NC_003155.4 hypothetical protein 7008325 1216296 SAV_5801 Streptomyces avermitilis MA-4680 hypothetical protein NP_826978.1 7007846 D 227882 CDS NP_826979.1 29832345 1211347 7008510..7008968 1 NC_003155.4 thiol-specific antioxidant protein 7008968 ahpE 1211347 ahpE Streptomyces avermitilis MA-4680 thiol-specific antioxidant protein NP_826979.1 7008510 D 227882 CDS NP_826980.1 29832346 1216297 7009081..7009656 1 NC_003155.4 PF02342: Bacterial stress protein; tellurium resistance protein 7009656 terD3 1216297 terD3 Streptomyces avermitilis MA-4680 tellurium resistance protein NP_826980.1 7009081 D 227882 CDS NP_826981.1 29832347 1216298 7009785..7010360 1 NC_003155.4 PF02342: Bacterial stress protein; tellurium resistance protein 7010360 terD4 1216298 terD4 Streptomyces avermitilis MA-4680 tellurium resistance protein NP_826981.1 7009785 D 227882 CDS NP_826982.1 29832348 1216299 7010466..7011611 1 NC_003155.4 PF04332: Protein of unknown function (DUF475); hypothetical protein 7011611 1216299 SAV_5805 Streptomyces avermitilis MA-4680 hypothetical protein NP_826982.1 7010466 D 227882 CDS NP_826983.1 29832349 1216300 7011775..7012509 1 NC_003155.4 PF02342: Bacterial stress protein; hypothetical protein 7012509 1216300 SAV_5806 Streptomyces avermitilis MA-4680 hypothetical protein NP_826983.1 7011775 D 227882 CDS NP_826984.1 29832350 1216301 complement(7012537..7013463) 1 NC_003155.4 PF02342: Bacterial stress protein; hypothetical protein 7013463 1216301 SAV_5807 Streptomyces avermitilis MA-4680 hypothetical protein NP_826984.1 7012537 R 227882 CDS NP_826985.1 29832351 1216302 7013655..7014818 1 NC_003155.4 ATP/GTP-binding protein 7014818 1216302 SAV_5808 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_826985.1 7013655 D 227882 CDS NP_826986.1 29832352 1216303 7014926..7017394 1 NC_003155.4 hypothetical protein 7017394 1216303 SAV_5809 Streptomyces avermitilis MA-4680 hypothetical protein NP_826986.1 7014926 D 227882 CDS NP_826987.1 29832353 1216304 7017394..7018212 1 NC_003155.4 hypothetical protein 7018212 1216304 SAV_5810 Streptomyces avermitilis MA-4680 hypothetical protein NP_826987.1 7017394 D 227882 CDS NP_826988.1 29832354 1216305 complement(7018297..7018524) 1 NC_003155.4 hypothetical protein 7018524 1216305 SAV_5811 Streptomyces avermitilis MA-4680 hypothetical protein NP_826988.1 7018297 R 227882 CDS NP_826989.1 29832355 1216306 complement(7018528..7019208) 1 NC_003155.4 hypothetical protein 7019208 1216306 SAV_5812 Streptomyces avermitilis MA-4680 hypothetical protein NP_826989.1 7018528 R 227882 CDS NP_826990.1 29832356 1216307 complement(7019337..7020761) 1 NC_003155.4 PF01442: Apolipoprotein A1/A4/E family; hypothetical protein 7020761 1216307 SAV_5813 Streptomyces avermitilis MA-4680 hypothetical protein NP_826990.1 7019337 R 227882 CDS NP_826991.1 29832357 1216308 complement(7020916..7021716) 1 NC_003155.4 lipoprotein 7021716 1216308 SAV_5814 Streptomyces avermitilis MA-4680 lipoprotein NP_826991.1 7020916 R 227882 CDS NP_826992.1 29832358 1216309 complement(7022151..7022579) 1 NC_003155.4 PF00589: Phage integrase family; integrase 7022579 int15 1216309 int15 Streptomyces avermitilis MA-4680 integrase NP_826992.1 7022151 R 227882 CDS NP_826993.1 29832359 1216310 7023358..7024203 1 NC_003155.4 hypothetical protein 7024203 1216310 SAV_5816 Streptomyces avermitilis MA-4680 hypothetical protein NP_826993.1 7023358 D 227882 CDS NP_826994.1 29832360 1216311 7024312..7025148 1 NC_003155.4 hypothetical protein 7025148 1216311 SAV_5817 Streptomyces avermitilis MA-4680 hypothetical protein NP_826994.1 7024312 D 227882 CDS NP_826995.1 29832361 1216312 complement(7025513..7025833) 1 NC_003155.4 hypothetical protein 7025833 1216312 SAV_5818 Streptomyces avermitilis MA-4680 hypothetical protein NP_826995.1 7025513 R 227882 CDS NP_826996.1 29832362 1216313 complement(7025939..7026895) 1 NC_003155.4 PF02558: Ketopantoate reductase PanE/ApbA; oxidoreductase 7026895 1216313 SAV_5819 Streptomyces avermitilis MA-4680 oxidoreductase NP_826996.1 7025939 R 227882 CDS NP_826997.1 29832363 1216314 complement(7027009..7027419) 1 NC_003155.4 hypothetical protein 7027419 1216314 SAV_5820 Streptomyces avermitilis MA-4680 hypothetical protein NP_826997.1 7027009 R 227882 CDS NP_826998.1 29832364 1216315 complement(7027524..7027787) 1 NC_003155.4 hypothetical protein 7027787 1216315 SAV_5821 Streptomyces avermitilis MA-4680 hypothetical protein NP_826998.1 7027524 R 227882 CDS NP_826999.1 29832365 1216316 7027841..7028095 1 NC_003155.4 hypothetical protein 7028095 1216316 SAV_5822 Streptomyces avermitilis MA-4680 hypothetical protein NP_826999.1 7027841 D 227882 CDS NP_827000.1 29832366 1216317 complement(7028067..7028678) 1 NC_003155.4 PF00597: DedA family; hypothetical protein 7028678 1216317 SAV_5823 Streptomyces avermitilis MA-4680 hypothetical protein NP_827000.1 7028067 R 227882 CDS NP_827001.1 29832367 1216318 complement(7028956..7029411) 1 NC_003155.4 PF07681: DoxX; hypothetical protein 7029411 1216318 SAV_5824 Streptomyces avermitilis MA-4680 hypothetical protein NP_827001.1 7028956 R 227882 CDS NP_827002.1 29832368 1216319 complement(7029500..7031464) 1 NC_003155.4 hypothetical protein 7031464 1216319 SAV_5825 Streptomyces avermitilis MA-4680 hypothetical protein NP_827002.1 7029500 R 227882 CDS NP_827003.1 29832369 1216320 complement(7031672..7033306) 1 NC_003155.4 hypothetical protein 7033306 1216320 SAV_5826 Streptomyces avermitilis MA-4680 hypothetical protein NP_827003.1 7031672 R 227882 CDS NP_827004.1 29832370 1216321 complement(7033386..7034030) 1 NC_003155.4 protein 7034030 1216321 SAV_5827 Streptomyces avermitilis MA-4680 protein NP_827004.1 7033386 R 227882 CDS NP_827005.1 29832371 1216322 7034613..7035194 1 NC_003155.4 PF01169: Uncharacterized protein family UPF0016; hypothetical protein 7035194 1216322 SAV_5828 Streptomyces avermitilis MA-4680 hypothetical protein NP_827005.1 7034613 D 227882 CDS NP_827006.1 29832372 1216323 7035454..7036116 1 NC_003155.4 PF00702: haloacid dehalogenase-like hydrolase; hydrolase 7036116 1216323 SAV_5829 Streptomyces avermitilis MA-4680 hydrolase NP_827006.1 7035454 D 227882 CDS NP_827007.1 29832373 1216324 complement(7036327..7037331) 1 NC_003155.4 PF01471: Putative peptidoglycan binding domain; peptidoglycan-binding membrane protein 7037331 1216324 SAV_5830 Streptomyces avermitilis MA-4680 peptidoglycan-binding membrane protein NP_827007.1 7036327 R 227882 CDS NP_827008.1 29832374 1216325 7037506..7039593 1 NC_003155.4 PF07690: Major Facilitator Superfamily; multidrug-efflux transporter 7039593 1216325 SAV_5831 Streptomyces avermitilis MA-4680 multidrug-efflux transporter NP_827008.1 7037506 D 227882 CDS NP_827009.1 29832375 1216326 complement(7039590..7040132) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 7040132 1216326 SAV_5832 Streptomyces avermitilis MA-4680 acetyltransferase NP_827009.1 7039590 R 227882 CDS NP_827010.1 29832376 1216327 7040278..7041012 1 NC_003155.4 protein 7041012 1216327 SAV_5833 Streptomyces avermitilis MA-4680 protein NP_827010.1 7040278 D 227882 CDS NP_827011.1 29832377 1216328 7041018..7041797 1 NC_003155.4 hypothetical protein 7041797 1216328 SAV_5834 Streptomyces avermitilis MA-4680 hypothetical protein NP_827011.1 7041018 D 227882 CDS NP_827012.1 29832378 1216329 complement(7041912..7042325) 1 NC_003155.4 hypothetical protein 7042325 1216329 SAV_5835 Streptomyces avermitilis MA-4680 hypothetical protein NP_827012.1 7041912 R 227882 CDS NP_827013.1 29832379 1216330 7042375..7042836 1 NC_003155.4 hypothetical protein 7042836 1216330 SAV_5836 Streptomyces avermitilis MA-4680 hypothetical protein NP_827013.1 7042375 D 227882 CDS NP_827014.1 29832380 1216331 complement(7042860..7043534) 1 NC_003155.4 O-methyltransferase 7043534 1216331 SAV_5837 Streptomyces avermitilis MA-4680 O-methyltransferase NP_827014.1 7042860 R 227882 CDS NP_827015.1 29832381 1216332 complement(7043634..7044782) 1 NC_003155.4 hypothetical protein 7044782 1216332 SAV_5838 Streptomyces avermitilis MA-4680 hypothetical protein NP_827015.1 7043634 R 227882 CDS NP_827016.1 29832382 1216333 complement(7044873..7046345) 1 NC_003155.4 PF00083: Sugar (and other) transporter; integral membrane transport protein 7046345 1216333 SAV_5839 Streptomyces avermitilis MA-4680 integral membrane transport protein NP_827016.1 7044873 R 227882 CDS NP_827017.1 29832383 1216334 7046733..7047638 1 NC_003155.4 integral membrane protein 7047638 1216334 SAV_5840 Streptomyces avermitilis MA-4680 integral membrane protein NP_827017.1 7046733 D 227882 CDS NP_827018.1 29832384 1211349 complement(7047868..7049112) 1 NC_003155.4 CYP125A2, fadA7 is located at upstream; cytochrome P450 hydroxylase 7049112 cyp22 1211349 cyp22 Streptomyces avermitilis MA-4680 cytochrome P450 hydroxylase NP_827018.1 7047868 R 227882 CDS NP_827019.1 29832385 1211350 7049394..7050563 1 NC_003155.4 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 7050563 fadA7 1211350 fadA7 Streptomyces avermitilis MA-4680 acetyl-CoA acetyltransferase NP_827019.1 7049394 D 227882 CDS NP_827020.1 29832386 1216335 complement(7050588..7051283) 1 NC_003155.4 PF06912: Protein of unknown function (DUF1275); hypothetical protein 7051283 1216335 SAV_5843 Streptomyces avermitilis MA-4680 hypothetical protein NP_827020.1 7050588 R 227882 CDS NP_827021.1 29832387 1216336 7051388..7052638 1 NC_003155.4 PF03583: Secretory lipase; hypothetical protein 7052638 1216336 SAV_5844 Streptomyces avermitilis MA-4680 hypothetical protein NP_827021.1 7051388 D 227882 CDS NP_827022.1 29832388 1216337 complement(7052717..7053178) 1 NC_003155.4 PF06737: Transglycosylase-like domain; hypothetical protein 7053178 1216337 SAV_5845 Streptomyces avermitilis MA-4680 hypothetical protein NP_827022.1 7052717 R 227882 CDS NP_827023.1 29832389 1216338 complement(7053469..7054434) 1 NC_003155.4 integral membrane protein 7054434 1216338 SAV_5846 Streptomyces avermitilis MA-4680 integral membrane protein NP_827023.1 7053469 R 227882 CDS NP_827024.1 29832390 1216339 complement(7054431..7056116) 1 NC_003155.4 ABC transporter ATP-binding protein 7056116 1216339 SAV_5847 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_827024.1 7054431 R 227882 CDS NP_827025.1 29832391 1216340 complement(7056113..7057258) 1 NC_003155.4 PF02361: Cobalt transport protein; integral membrane protein 7057258 1216340 SAV_5848 Streptomyces avermitilis MA-4680 integral membrane protein NP_827025.1 7056113 R 227882 CDS NP_827026.1 29832392 1216341 complement(7057265..7057939) 1 NC_003155.4 hypothetical protein 7057939 1216341 SAV_5849 Streptomyces avermitilis MA-4680 hypothetical protein NP_827026.1 7057265 R 227882 CDS NP_827027.1 29832393 1216342 complement(7057936..7059213) 1 NC_003155.4 PF00432: Prenyltransferase and squalene oxidase repeat; hypothetical protein 7059213 1216342 SAV_5850 Streptomyces avermitilis MA-4680 hypothetical protein NP_827027.1 7057936 R 227882 CDS NP_827028.1 29832394 1216343 complement(7059531..7060649) 1 NC_003155.4 PF00753: Metallo-beta-lactamase superfamily; hypothetical protein 7060649 1216343 SAV_5851 Streptomyces avermitilis MA-4680 hypothetical protein NP_827028.1 7059531 R 227882 CDS NP_827029.1 29832395 1216344 7060741..7062249 1 NC_003155.4 PF00171: Aldehyde dehydrogenase family; aldehyde dehydrogenase 7062249 1216344 SAV_5852 Streptomyces avermitilis MA-4680 aldehyde dehydrogenase NP_827029.1 7060741 D 227882 CDS NP_827030.1 29832396 1211351 7062249..7062482 1 NC_003155.4 ferredoxin 7062482 fdxF 1211351 fdxF Streptomyces avermitilis MA-4680 ferredoxin NP_827030.1 7062249 D 227882 CDS NP_827031.1 29832397 1216345 complement(7062720..7063376) 1 NC_003155.4 TetR family transcriptional regulator 7063376 1216345 SAV_5854 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_827031.1 7062720 R 227882 CDS NP_827032.1 29832398 1216346 7063585..7065060 1 NC_003155.4 PF00534: Glycosyl transferases group 1; glycosyl transferase 7065060 1216346 SAV_5855 Streptomyces avermitilis MA-4680 glycosyl transferase NP_827032.1 7063585 D 227882 CDS NP_827033.1 29832399 1216347 7065054..7065800 1 NC_003155.4 methyltransferase 7065800 1216347 SAV_5856 Streptomyces avermitilis MA-4680 methyltransferase NP_827033.1 7065054 D 227882 CDS NP_827034.1 29832400 1216348 7065797..7066867 1 NC_003155.4 hypothetical protein 7066867 1216348 SAV_5857 Streptomyces avermitilis MA-4680 hypothetical protein NP_827034.1 7065797 D 227882 CDS NP_827035.1 29832401 1216349 complement(7066928..7067221) 1 NC_003155.4 hypothetical protein 7067221 1216349 SAV_5858 Streptomyces avermitilis MA-4680 hypothetical protein NP_827035.1 7066928 R 227882 CDS NP_827036.1 29832402 1216350 7067360..7067920 1 NC_003155.4 hypothetical protein 7067920 1216350 SAV_5859 Streptomyces avermitilis MA-4680 hypothetical protein NP_827036.1 7067360 D 227882 CDS NP_827037.1 29832403 1216351 7068139..7068789 1 NC_003155.4 hypothetical protein 7068789 1216351 SAV_5860 Streptomyces avermitilis MA-4680 hypothetical protein NP_827037.1 7068139 D 227882 CDS NP_827038.1 29832404 1216352 7068812..7069810 1 NC_003155.4 PF01520: N-acetylmuramoyl-L-alanine amidase; hypothetical protein 7069810 1216352 SAV_5861 Streptomyces avermitilis MA-4680 hypothetical protein NP_827038.1 7068812 D 227882 CDS NP_827039.1 29832405 1216353 complement(7069951..7070586) 1 NC_003155.4 hypothetical protein 7070586 1216353 SAV_5862 Streptomyces avermitilis MA-4680 hypothetical protein NP_827039.1 7069951 R 227882 CDS NP_827040.1 29832406 1216354 7070987..7071784 1 NC_003155.4 integral membrane protein 7071784 1216354 SAV_5863 Streptomyces avermitilis MA-4680 integral membrane protein NP_827040.1 7070987 D 227882 CDS NP_827041.1 29832407 1216355 7071899..7072909 1 NC_003155.4 PF00296: Luciferase-like monooxygenase; FMN-dependent monooxygenase 7072909 1216355 SAV_5864 Streptomyces avermitilis MA-4680 FMN-dependent monooxygenase NP_827041.1 7071899 D 227882 CDS NP_827042.1 29832408 1216356 complement(7073034..7074785) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; membrane transport protein 7074785 1216356 SAV_5865 Streptomyces avermitilis MA-4680 membrane transport protein NP_827042.1 7073034 R 227882 CDS NP_827043.1 29832409 1211352 7074961..7076199 1 NC_003155.4 lipid-transfer protein 7076199 ltp1 1211352 ltp1 Streptomyces avermitilis MA-4680 lipid-transfer protein NP_827043.1 7074961 D 227882 CDS NP_827044.1 29832410 1216357 7076342..7077796 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane transport protein 7077796 1216357 SAV_5867 Streptomyces avermitilis MA-4680 transmembrane transport protein NP_827044.1 7076342 D 227882 CDS NP_827045.1 29832411 1216358 complement(7077847..7078479) 1 NC_003155.4 two-component system response regulator 7078479 1216358 SAV_5868 Streptomyces avermitilis MA-4680 two-component system response regulator NP_827045.1 7077847 R 227882 CDS NP_827046.1 29832412 1216359 complement(7078512..7079885) 1 NC_003155.4 two-component system sensor kinase 7079885 1216359 SAV_5869 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_827046.1 7078512 R 227882 CDS NP_827047.1 29832413 1216360 7080294..7081151 1 NC_003155.4 UfaA2 protein 7081151 1216360 SAV_5870 Streptomyces avermitilis MA-4680 UfaA2 protein NP_827047.1 7080294 D 227882 CDS NP_827048.1 29832414 1216361 7081196..7082272 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 7082272 1216361 SAV_5871 Streptomyces avermitilis MA-4680 dehydrogenase NP_827048.1 7081196 D 227882 CDS NP_827049.1 29832415 1211353 7082308..7083282 1 NC_003155.4 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 7083282 fabG 1211353 fabG Streptomyces avermitilis MA-4680 3-ketoacyl-ACP reductase NP_827049.1 7082308 D 227882 CDS NP_827050.1 29832416 1216362 complement(7083426..7083590) 1 NC_003155.4 hypothetical protein 7083590 1216362 SAV_5873 Streptomyces avermitilis MA-4680 hypothetical protein NP_827050.1 7083426 R 227882 CDS NP_827051.1 29832417 1216363 complement(7083639..7084970) 1 NC_003155.4 hypothetical protein 7084970 1216363 SAV_5874 Streptomyces avermitilis MA-4680 hypothetical protein NP_827051.1 7083639 R 227882 CDS NP_827052.1 29832418 1216364 7085244..7086107 1 NC_003155.4 PF01784: NIF3 (NGG1p interacting factor 3); NGG1-interacting factor 3 7086107 1216364 SAV_5875 Streptomyces avermitilis MA-4680 NGG1-interacting factor 3 NP_827052.1 7085244 D 227882 CDS NP_827053.1 29832419 1216365 7086257..7086847 1 NC_003155.4 PF02591: Uncharacterized ACR, COG1579; hypothetical protein 7086847 1216365 SAV_5876 Streptomyces avermitilis MA-4680 hypothetical protein NP_827053.1 7086257 D 227882 CDS NP_827054.1 29832420 1216366 7086857..7088173 1 NC_003155.4 bifunctional RNase H/acid phosphatase 7088173 1216366 SAV_5877 Streptomyces avermitilis MA-4680 bifunctional RNase H/acid phosphatase NP_827054.1 7086857 D 227882 CDS NP_827055.1 29832421 1211354 complement(7088283..7088942) 1 NC_003155.4 2-keto-3-deoxygluconate 6-phosphate aldolase and 2-keto-4-hydroxyglutarate aldolase 7088942 kdgA 1211354 kdgA Streptomyces avermitilis MA-4680 2-keto-3-deoxygluconate 6-phosphate aldolase and 2-keto-4-hydroxyglutarate aldolase NP_827055.1 7088283 R 227882 CDS NP_827056.1 29832422 1216367 complement(7089039..7089839) 1 NC_003155.4 PF03883: Protein of unknown function (DUF328); hypothetical protein 7089839 1216367 SAV_5879 Streptomyces avermitilis MA-4680 hypothetical protein NP_827056.1 7089039 R 227882 CDS NP_827057.1 29832423 1216368 7090363..7091718 1 NC_003155.4 PF00773: RNB-like protein; ribonuclease R 7091718 rnr 1216368 rnr Streptomyces avermitilis MA-4680 ribonuclease R NP_827057.1 7090363 D 227882 CDS NP_827058.1 29832424 1216369 7091804..7092652 1 NC_003155.4 AraC family transcription regulator 7092652 1216369 SAV_5881 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_827058.1 7091804 D 227882 CDS NP_827059.1 29832425 1216370 7092672..7093748 1 NC_003155.4 PF00892: Integral membrane protein DUF6; integral membrane protein 7093748 1216370 SAV_5882 Streptomyces avermitilis MA-4680 integral membrane protein NP_827059.1 7092672 D 227882 CDS NP_827060.1 29832426 1216371 complement(7094601..7095764) 1 NC_003155.4 O-methyltransferase 7095764 1216371 SAV_5883 Streptomyces avermitilis MA-4680 O-methyltransferase NP_827060.1 7094601 R 227882 CDS NP_827061.1 29832427 1216372 complement(7095761..7096726) 1 NC_003155.4 hypothetical protein 7096726 1216372 SAV_5884 Streptomyces avermitilis MA-4680 hypothetical protein NP_827061.1 7095761 R 227882 CDS NP_827062.1 29832428 1216373 complement(7096726..7096986) 1 NC_003155.4 hypothetical protein 7096986 1216373 SAV_5885 Streptomyces avermitilis MA-4680 hypothetical protein NP_827062.1 7096726 R 227882 CDS NP_827063.1 29832429 1216374 complement(7097219..7097425) 1 NC_003155.4 hypothetical protein 7097425 1216374 SAV_5886 Streptomyces avermitilis MA-4680 hypothetical protein NP_827063.1 7097219 R 227882 CDS NP_827064.1 29832430 1216375 7097918..7099063 1 NC_003155.4 PF06036: Streptomyces protein of unknown function (DUF921); hypothetical protein 7099063 1216375 SAV_5887 Streptomyces avermitilis MA-4680 hypothetical protein NP_827064.1 7097918 D 227882 CDS NP_827065.1 29832431 1216376 7099080..7099433 1 NC_003155.4 hypothetical protein 7099433 1216376 SAV_5888 Streptomyces avermitilis MA-4680 hypothetical protein NP_827065.1 7099080 D 227882 CDS NP_827066.1 29832432 1216377 complement(7099811..7100128) 1 NC_003155.4 hypothetical protein 7100128 1216377 SAV_5889 Streptomyces avermitilis MA-4680 hypothetical protein NP_827066.1 7099811 R 227882 CDS NP_827067.1 29832433 1216378 7100211..7101026 1 NC_003155.4 PF04672: Protein of unknown function (DUF574); hypothetical protein 7101026 1216378 SAV_5890 Streptomyces avermitilis MA-4680 hypothetical protein NP_827067.1 7100211 D 227882 CDS NP_827068.1 29832434 1216379 7101223..7101762 1 NC_003155.4 PF05079: Protein of unknown function (DUF680); hypothetical protein 7101762 1216379 SAV_5891 Streptomyces avermitilis MA-4680 hypothetical protein NP_827068.1 7101223 D 227882 CDS NP_827069.1 29832435 1216380 complement(7101854..7102672) 1 NC_003155.4 hypothetical protein 7102672 1216380 SAV_5892 Streptomyces avermitilis MA-4680 hypothetical protein NP_827069.1 7101854 R 227882 CDS NP_827070.1 29832436 1216381 complement(7102713..7103246) 1 NC_003155.4 hypothetical protein 7103246 1216381 SAV_5893 Streptomyces avermitilis MA-4680 hypothetical protein NP_827070.1 7102713 R 227882 CDS NP_827071.1 29832437 1216382 complement(7103213..7104490) 1 NC_003155.4 mceF, PF02470: mce related protein; mce-related protein 7104490 1216382 SAV_5894 Streptomyces avermitilis MA-4680 mce-related protein NP_827071.1 7103213 R 227882 CDS NP_827072.1 29832438 1216383 complement(7104487..7105764) 1 NC_003155.4 mceE, PF02470: mce related protein; mce-related protein 7105764 1216383 SAV_5895 Streptomyces avermitilis MA-4680 mce-related protein NP_827072.1 7104487 R 227882 CDS NP_827073.1 29832439 1216384 complement(7105761..7106885) 1 NC_003155.4 mceD, PF02470: mce related protein; mce-related protein 7106885 1216384 SAV_5896 Streptomyces avermitilis MA-4680 mce-related protein NP_827073.1 7105761 R 227882 CDS NP_827074.1 29832440 1216385 complement(7106882..7108060) 1 NC_003155.4 mceC, PF02470: mce related protein; mce-related protein 7108060 1216385 SAV_5897 Streptomyces avermitilis MA-4680 mce-related protein NP_827074.1 7106882 R 227882 CDS NP_827075.1 29832441 1216386 complement(7108057..7109148) 1 NC_003155.4 mceB, PF02470: mce related protein; mce-related protein 7109148 1216386 SAV_5898 Streptomyces avermitilis MA-4680 mce-related protein NP_827075.1 7108057 R 227882 CDS NP_827076.1 29832442 1216387 complement(7109145..7110392) 1 NC_003155.4 mceA, PF02470: mce related protein; mce-related protein 7110392 1216387 SAV_5899 Streptomyces avermitilis MA-4680 mce-related protein NP_827076.1 7109145 R 227882 CDS NP_827077.1 29832443 1216388 complement(7110389..7111192) 1 NC_003155.4 ABC transporter permease 7111192 1216388 SAV_5900 Streptomyces avermitilis MA-4680 ABC transporter permease NP_827077.1 7110389 R 227882 CDS NP_827078.1 29832444 1216389 complement(7111196..7111966) 1 NC_003155.4 ABC transporter permease 7111966 1216389 SAV_5901 Streptomyces avermitilis MA-4680 ABC transporter permease NP_827078.1 7111196 R 227882 CDS NP_827079.1 29832445 1216390 complement(7111963..7112943) 1 NC_003155.4 ABC transporter ATP-binding protein 7112943 1216390 SAV_5902 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_827079.1 7111963 R 227882 CDS NP_827080.1 29832446 1211355 complement(7113078..7114112) 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 7114112 sig48 1211355 sig48 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_827080.1 7113078 R 227882 CDS NP_827081.1 29832447 1216391 complement(7114167..7115219) 1 NC_003155.4 PF01464: Transglycosylase SLT domain; protein 7115219 1216391 SAV_5904 Streptomyces avermitilis MA-4680 protein NP_827081.1 7114167 R 227882 CDS NP_827082.1 29832448 1216392 complement(7115405..7117315) 1 NC_003155.4 hypothetical protein 7117315 1216392 SAV_5905 Streptomyces avermitilis MA-4680 hypothetical protein NP_827082.1 7115405 R 227882 CDS NP_827083.1 29832449 1216393 complement(7117325..7117882) 1 NC_003155.4 hypothetical protein 7117882 1216393 SAV_5906 Streptomyces avermitilis MA-4680 hypothetical protein NP_827083.1 7117325 R 227882 CDS NP_827084.1 29832450 1216394 complement(7118092..7119543) 1 NC_003155.4 hypothetical protein 7119543 1216394 SAV_5907 Streptomyces avermitilis MA-4680 hypothetical protein NP_827084.1 7118092 R 227882 CDS NP_827085.1 29832451 1216395 complement(7119676..7120029) 1 NC_003155.4 PF03819: MazG nucleotide pyrophosphohydrolase domain; hypothetical protein 7120029 1216395 SAV_5908 Streptomyces avermitilis MA-4680 hypothetical protein NP_827085.1 7119676 R 227882 CDS NP_827086.1 29832452 1216396 complement(7120052..7120597) 1 NC_003155.4 PF07681: DoxX; hypothetical protein 7120597 1216396 SAV_5909 Streptomyces avermitilis MA-4680 hypothetical protein NP_827086.1 7120052 R 227882 CDS NP_827087.1 29832453 1216397 7120763..7121089 1 NC_003155.4 hypothetical protein 7121089 1216397 SAV_5910 Streptomyces avermitilis MA-4680 hypothetical protein NP_827087.1 7120763 D 227882 CDS NP_827088.1 29832454 1216398 complement(7121220..7121960) 1 NC_003155.4 ABC transporter ATP-binding protein 7121960 1216398 SAV_5911 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_827088.1 7121220 R 227882 CDS NP_827089.1 29832455 1216399 complement(7122065..7123522) 1 NC_003155.4 PF02687: Predicted permease; integral membrane protein 7123522 1216399 SAV_5912 Streptomyces avermitilis MA-4680 integral membrane protein NP_827089.1 7122065 R 227882 CDS NP_827090.1 29832456 1211356 7123858..7125198 1 NC_003155.4 PF00768: D-alanyl-D-alanine carboxypeptidase; D-alanyl-D-alanine carboxypeptidase 7125198 dacF 1211356 dacF Streptomyces avermitilis MA-4680 D-alanyl-D-alanine carboxypeptidase NP_827090.1 7123858 D 227882 CDS NP_827091.1 29832457 1216400 complement(7125477..7126298) 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 7126298 1216400 SAV_5914 Streptomyces avermitilis MA-4680 dehydrogenase NP_827091.1 7125477 R 227882 CDS NP_827092.1 29832458 1211357 7126402..7128048 1 NC_003155.4 alkaline phosphatase 7128048 phoA 1211357 phoA Streptomyces avermitilis MA-4680 alkaline phosphatase NP_827092.1 7126402 D 227882 CDS NP_827093.1 29832459 1216401 complement(7128195..7129202) 1 NC_003155.4 PF01408: Oxidoreductase family, NAD-binding Rossmann fold; oxidoreductase 7129202 1216401 SAV_5916 Streptomyces avermitilis MA-4680 oxidoreductase NP_827093.1 7128195 R 227882 CDS NP_827094.1 29832460 1216402 7129278..7130717 1 NC_003155.4 PF07690: Major Facilitator Superfamily; bicyclomycin resistance protein 7130717 1216402 SAV_5917 Streptomyces avermitilis MA-4680 bicyclomycin resistance protein NP_827094.1 7129278 D 227882 CDS NP_827095.1 29832461 1216403 7130795..7131844 1 NC_003155.4 PF00144: Beta-lactamase; beta-lactamase 7131844 blaA6 1216403 blaA6 Streptomyces avermitilis MA-4680 beta-lactamase NP_827095.1 7130795 D 227882 CDS NP_827096.1 29832462 1216404 7131857..7132855 1 NC_003155.4 hypothetical protein 7132855 1216404 SAV_5919 Streptomyces avermitilis MA-4680 hypothetical protein NP_827096.1 7131857 D 227882 CDS NP_827097.1 29832463 1216405 7132960..7133619 1 NC_003155.4 TetR family transcriptional regulator 7133619 1216405 SAV_5920 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_827097.1 7132960 D 227882 CDS NP_827098.1 29832464 1216406 complement(7133588..7134478) 1 NC_003155.4 glycerophosphoryl diester phosphodiesterase 7134478 glpQ7 1216406 glpQ7 Streptomyces avermitilis MA-4680 glycerophosphoryl diester phosphodiesterase NP_827098.1 7133588 R 227882 CDS NP_827099.1 29832465 1216407 7134665..7135393 1 NC_003155.4 hypothetical protein 7135393 1216407 SAV_5922 Streptomyces avermitilis MA-4680 hypothetical protein NP_827099.1 7134665 D 227882 CDS NP_827100.1 29832466 1216408 complement(7135421..7136491) 1 NC_003155.4 hypothetical protein 7136491 1216408 SAV_5923 Streptomyces avermitilis MA-4680 hypothetical protein NP_827100.1 7135421 R 227882 CDS NP_827101.1 29832467 1216409 complement(7136524..7137390) 1 NC_003155.4 PF03239: Iron permease FTR1 family; hypothetical protein 7137390 1216409 SAV_5924 Streptomyces avermitilis MA-4680 hypothetical protein NP_827101.1 7136524 R 227882 CDS NP_827102.1 29832468 1216410 complement(7137394..7138692) 1 NC_003155.4 This family of dye-decolourising peroxidases lack a typical heme-binding region; iron-dependent peroxidase 7138692 1216410 SAV_5925 Streptomyces avermitilis MA-4680 iron-dependent peroxidase NP_827102.1 7137394 R 227882 CDS NP_827103.1 29832469 1216411 complement(7138689..7139837) 1 NC_003155.4 PF04302: Protein of unknown function (DUF451); lipoprotein 7139837 1216411 SAV_5926 Streptomyces avermitilis MA-4680 lipoprotein NP_827103.1 7138689 R 227882 CDS NP_827104.1 29832470 1216412 complement(7139994..7140248) 1 NC_003155.4 hypothetical protein 7140248 1216412 SAV_5927 Streptomyces avermitilis MA-4680 hypothetical protein NP_827104.1 7139994 R 227882 CDS NP_827105.1 29832471 1216413 7140301..7141176 1 NC_003155.4 hypothetical protein 7141176 1216413 SAV_5928 Streptomyces avermitilis MA-4680 hypothetical protein NP_827105.1 7140301 D 227882 CDS NP_827106.1 29832472 1216414 7141169..7141813 1 NC_003155.4 PF02567: phenazine biosynthesis-like protein; hypothetical protein 7141813 1216414 SAV_5929 Streptomyces avermitilis MA-4680 hypothetical protein NP_827106.1 7141169 D 227882 CDS NP_827107.1 29832473 1216415 complement(7141893..7142540) 1 NC_003155.4 heme oxygenase 7142540 hmuO 1216415 hmuO Streptomyces avermitilis MA-4680 heme oxygenase NP_827107.1 7141893 R 227882 CDS NP_827108.1 29832474 1216416 complement(7142715..7143572) 1 NC_003155.4 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 7143572 map4 1216416 map4 Streptomyces avermitilis MA-4680 methionine aminopeptidase NP_827108.1 7142715 R 227882 CDS NP_827109.1 29832475 1216417 7143631..7143867 1 NC_003155.4 hypothetical protein 7143867 1216417 SAV_5932 Streptomyces avermitilis MA-4680 hypothetical protein NP_827109.1 7143631 D 227882 CDS NP_827110.1 29832476 1216418 complement(7144040..7144648) 1 NC_003155.4 hypothetical protein 7144648 1216418 SAV_5933 Streptomyces avermitilis MA-4680 hypothetical protein NP_827110.1 7144040 R 227882 CDS NP_827111.1 29832477 1216419 7144755..7145828 1 NC_003155.4 neuramidase 7145828 1216419 SAV_5934 Streptomyces avermitilis MA-4680 neuramidase NP_827111.1 7144755 D 227882 CDS NP_827112.1 29832478 1216420 7145867..7146571 1 NC_003155.4 PF03807: NADP oxidoreductase coenzyme F420-dependent; NADPH-dependent F420 reductase 7146571 1216420 SAV_5935 Streptomyces avermitilis MA-4680 NADPH-dependent F420 reductase NP_827112.1 7145867 D 227882 CDS NP_827113.1 29832479 1216421 7146634..7146816 1 NC_003155.4 hypothetical protein 7146816 1216421 SAV_5936 Streptomyces avermitilis MA-4680 hypothetical protein NP_827113.1 7146634 D 227882 CDS NP_827114.1 29832480 1216422 complement(7146806..7147606) 1 NC_003155.4 PF02163: Peptidase family M50; hypothetical protein 7147606 1216422 SAV_5937 Streptomyces avermitilis MA-4680 hypothetical protein NP_827114.1 7146806 R 227882 CDS NP_827115.1 29832481 1216423 7147711..7148265 1 NC_003155.4 hypothetical protein 7148265 1216423 SAV_5938 Streptomyces avermitilis MA-4680 hypothetical protein NP_827115.1 7147711 D 227882 CDS NP_827116.1 29832482 1216424 7148262..7151792 1 NC_003155.4 hypothetical protein 7151792 1216424 SAV_5939 Streptomyces avermitilis MA-4680 hypothetical protein NP_827116.1 7148262 D 227882 CDS NP_827117.1 29832483 1216425 complement(7151814..7152632) 1 NC_003155.4 ABC transporter permease 7152632 1216425 SAV_5940 Streptomyces avermitilis MA-4680 ABC transporter permease NP_827117.1 7151814 R 227882 CDS NP_827118.1 29832484 1216426 complement(7152629..7153669) 1 NC_003155.4 ABC transporter ATP-binding protein 7153669 1216426 SAV_5941 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_827118.1 7152629 R 227882 CDS NP_827119.1 29832485 1216427 7153958..7154353 1 NC_003155.4 hypothetical protein 7154353 1216427 SAV_5942 Streptomyces avermitilis MA-4680 hypothetical protein NP_827119.1 7153958 D 227882 CDS NP_827120.1 29832486 1211358 complement(7154378..7155241) 1 NC_003155.4 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 7155241 panB 1211358 panB Streptomyces avermitilis MA-4680 3-methyl-2-oxobutanoate hydroxymethyltransferase NP_827120.1 7154378 R 227882 CDS NP_827121.1 29832487 1216428 7155444..7157036 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 7157036 1216428 SAV_5944 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_827121.1 7155444 D 227882 CDS NP_827122.1 29832488 1216429 7157137..7157757 1 NC_003155.4 TetR family transcriptional regulator 7157757 1216429 SAV_5945 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_827122.1 7157137 D 227882 CDS NP_827123.1 29832489 1216430 7158034..7159071 1 NC_003155.4 PF03372: Endonuclease/Exonuclease/phosphatase family; hypothetical protein 7159071 1216430 SAV_5946 Streptomyces avermitilis MA-4680 hypothetical protein NP_827123.1 7158034 D 227882 CDS NP_827124.1 29832490 1216431 7159217..7160443 1 NC_003155.4 similar to cmlR, PF07690: Major Facilitator Superfamily; transmembrane efflux protein 7160443 1216431 SAV_5947 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_827124.1 7159217 D 227882 CDS NP_827125.1 29832491 1211359 complement(7160537..7162291) 1 NC_003155.4 NH(3)-dependent NAD(+) synthetase 7162291 nadE 1211359 nadE Streptomyces avermitilis MA-4680 NH(3)-dependent NAD(+) synthetase NP_827125.1 7160537 R 227882 CDS NP_827126.1 29832492 1216432 complement(7162675..7164576) 1 NC_003155.4 PF00082: Subtilase family; serine protease 7164576 1216432 SAV_5949 Streptomyces avermitilis MA-4680 serine protease NP_827126.1 7162675 R 227882 CDS NP_827127.1 29832493 1216433 complement(7164894..7165520) 1 NC_003155.4 PF03713: Domain of unknown function (DUF305); protein 7165520 1216433 SAV_5950 Streptomyces avermitilis MA-4680 protein NP_827127.1 7164894 R 227882 CDS NP_827128.1 29832494 1216434 complement(7165517..7166185) 1 NC_003155.4 hypothetical protein 7166185 1216434 SAV_5951 Streptomyces avermitilis MA-4680 hypothetical protein NP_827128.1 7165517 R 227882 CDS NP_827129.1 29832495 1216435 7166321..7166821 1 NC_003155.4 PF02082: Transcriptional regulator; hypothetical protein 7166821 1216435 SAV_5952 Streptomyces avermitilis MA-4680 hypothetical protein NP_827129.1 7166321 D 227882 CDS NP_827130.1 29832496 1216436 complement(7166776..7167978) 1 NC_003155.4 flavohemoprotein 7167978 fhbB 1216436 fhbB Streptomyces avermitilis MA-4680 flavohemoprotein NP_827130.1 7166776 R 227882 CDS NP_827131.1 29832497 1211360 7168307..7169668 1 NC_003155.4 glutamine synthetase 7169668 glnA1 1211360 glnA1 Streptomyces avermitilis MA-4680 glutamine synthetase NP_827131.1 7168307 D 227882 CDS NP_827132.1 29832498 1216437 complement(7169746..7170057) 1 NC_003155.4 hypothetical protein 7170057 1216437 SAV_5955 Streptomyces avermitilis MA-4680 hypothetical protein NP_827132.1 7169746 R 227882 CDS NP_827133.1 29832499 1216438 7170364..7170603 1 NC_003155.4 hypothetical protein 7170603 1216438 SAV_5956 Streptomyces avermitilis MA-4680 hypothetical protein NP_827133.1 7170364 D 227882 CDS NP_827134.1 29832500 1216439 7170603..7171262 1 NC_003155.4 hypothetical protein 7171262 1216439 SAV_5957 Streptomyces avermitilis MA-4680 hypothetical protein NP_827134.1 7170603 D 227882 CDS NP_827135.1 29832501 1216440 7171640..7173271 1 NC_003155.4 hypothetical protein 7173271 1216440 SAV_5958 Streptomyces avermitilis MA-4680 hypothetical protein NP_827135.1 7171640 D 227882 CDS NP_827136.1 29832502 1216441 7173320..7176457 1 NC_003155.4 LuxR family transcriptional regulator 7176457 1216441 SAV_5959 Streptomyces avermitilis MA-4680 LuxR family transcriptional regulator NP_827136.1 7173320 D 227882 CDS NP_827137.1 29832503 1216442 complement(7176435..7177229) 1 NC_003155.4 ABC transporter permease 7177229 1216442 SAV_5960 Streptomyces avermitilis MA-4680 ABC transporter permease NP_827137.1 7176435 R 227882 CDS NP_827138.1 29832504 1216443 complement(7177226..7178224) 1 NC_003155.4 ABC transporter ATP-binding protein 7178224 1216443 SAV_5961 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_827138.1 7177226 R 227882 CDS NP_827139.1 29832505 1216444 complement(7178491..7179432) 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein 7179432 1216444 SAV_5962 Streptomyces avermitilis MA-4680 hypothetical protein NP_827139.1 7178491 R 227882 CDS NP_827140.1 29832506 1216445 complement(7179438..7180094) 1 NC_003155.4 hypothetical protein 7180094 1216445 SAV_5963 Streptomyces avermitilis MA-4680 hypothetical protein NP_827140.1 7179438 R 227882 CDS NP_827141.1 29832507 1216446 complement(7180384..7180920) 1 NC_003155.4 hypothetical protein 7180920 1216446 SAV_5964 Streptomyces avermitilis MA-4680 hypothetical protein NP_827141.1 7180384 R 227882 CDS NP_827142.1 29832508 1216447 complement(7182115..7182849) 1 NC_003155.4 PF01738: Dienelactone hydrolase family; hydrolase 7182849 1216447 SAV_5965 Streptomyces avermitilis MA-4680 hydrolase NP_827142.1 7182115 R 227882 CDS NP_827143.1 29832509 1216448 complement(7183132..7183341) 1 NC_003155.4 PF04149: Domain of unknown function (DUF397); hypothetical protein 7183341 1216448 SAV_5966 Streptomyces avermitilis MA-4680 hypothetical protein NP_827143.1 7183132 R 227882 CDS NP_827144.1 29832510 1216449 complement(7183338..7183568) 1 NC_003155.4 hypothetical protein 7183568 1216449 SAV_5968 Streptomyces avermitilis MA-4680 hypothetical protein NP_827144.1 7183338 R 227882 CDS NP_827145.1 29832511 1216450 7183542..7183754 1 NC_003155.4 hypothetical protein 7183754 1216450 SAV_5967 Streptomyces avermitilis MA-4680 hypothetical protein NP_827145.1 7183542 D 227882 CDS NP_827146.1 29832512 1216451 complement(7183804..7184826) 1 NC_003155.4 hypothetical protein 7184826 1216451 SAV_5969 Streptomyces avermitilis MA-4680 hypothetical protein NP_827146.1 7183804 R 227882 CDS NP_827147.1 29832513 1216452 complement(7184823..7186142) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 7186142 1216452 SAV_5970 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_827147.1 7184823 R 227882 CDS NP_827148.1 29832514 1216453 complement(7186144..7187037) 1 NC_003155.4 acid phosphatase 7187037 1216453 SAV_5971 Streptomyces avermitilis MA-4680 acid phosphatase NP_827148.1 7186144 R 227882 CDS NP_827149.1 29832515 1211361 7187469..7190471 1 NC_003155.4 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 7190471 glnE 1211361 glnE Streptomyces avermitilis MA-4680 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase NP_827149.1 7187469 D 227882 CDS NP_827150.1 29832516 1216454 complement(7190459..7191448) 1 NC_003155.4 PF00892: Integral membrane protein DUF6; hypothetical protein 7191448 1216454 SAV_5973 Streptomyces avermitilis MA-4680 hypothetical protein NP_827150.1 7190459 R 227882 CDS NP_827151.1 29832517 1216455 7191520..7192413 1 NC_003155.4 LysR family transcriptional regulator 7192413 1216455 SAV_5974 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_827151.1 7191520 D 227882 CDS NP_827152.1 29832518 1216456 complement(7192845..7193720) 1 NC_003155.4 hypothetical protein 7193720 1216456 SAV_5975 Streptomyces avermitilis MA-4680 hypothetical protein NP_827152.1 7192845 R 227882 CDS NP_827153.1 29832519 1211362 complement(7193824..7194858) 1 NC_003155.4 LacI-family transcriptional regulator; repressor of malE transcription 7194858 malR1 1211362 malR1 Streptomyces avermitilis MA-4680 repressor of malE transcription NP_827153.1 7193824 R 227882 CDS NP_827154.1 29832520 1211363 7195314..7196585 1 NC_003155.4 ABC transporter substrate-binding protein; maltose-binding protein 7196585 malE 1211363 malE Streptomyces avermitilis MA-4680 maltose-binding protein NP_827154.1 7195314 D 227882 CDS NP_827155.1 29832521 1211364 7196707..7197711 1 NC_003155.4 ABC transporter permease; maltose permease 7197711 malF 1211364 malF Streptomyces avermitilis MA-4680 maltose permease NP_827155.1 7196707 D 227882 CDS NP_827156.1 29832522 1211365 7197731..7198639 1 NC_003155.4 ABC transporter permease; maltose permease 7198639 malG 1211365 malG Streptomyces avermitilis MA-4680 maltose permease NP_827156.1 7197731 D 227882 CDS NP_827157.1 29832523 1211366 7198686..7200536 1 NC_003155.4 alpha-glucosidase 7200536 aglA2 1211366 aglA2 Streptomyces avermitilis MA-4680 alpha-glucosidase NP_827157.1 7198686 D 227882 CDS NP_827158.1 29832524 1211367 7200765..7202147 1 NC_003155.4 alpha-amylase 7202147 amyA4 1211367 amyA4 Streptomyces avermitilis MA-4680 alpha-amylase NP_827158.1 7200765 D 227882 CDS NP_827159.1 29832525 1211368 7202286..7207706 1 NC_003155.4 pullulanase 7207706 amyX 1211368 amyX Streptomyces avermitilis MA-4680 pullulanase NP_827159.1 7202286 D 227882 CDS NP_827160.1 29832526 1216457 7207777..7209381 1 NC_003155.4 PF00072: Response regulator receiver domain; magnesium or manganese-dependent protein phosphatase 7209381 prpG2 1216457 prpG2 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_827160.1 7207777 D 227882 CDS NP_827161.1 29832527 1216458 7209413..7209769 1 NC_003155.4 isomerase 7209769 1216458 SAV_5984 Streptomyces avermitilis MA-4680 isomerase NP_827161.1 7209413 D 227882 CDS NP_827162.1 29832528 1216459 complement(7209773..7210474) 1 NC_003155.4 TetR family transcriptional regulator 7210474 1216459 SAV_5985 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_827162.1 7209773 R 227882 CDS NP_827163.1 29832529 1216460 complement(7210553..7212469) 1 NC_003155.4 hypothetical protein 7212469 1216460 SAV_5986 Streptomyces avermitilis MA-4680 hypothetical protein NP_827163.1 7210553 R 227882 CDS NP_827164.1 29832530 1216461 complement(7212627..7213139) 1 NC_003155.4 hypothetical protein 7213139 1216461 SAV_5987 Streptomyces avermitilis MA-4680 hypothetical protein NP_827164.1 7212627 R 227882 CDS NP_827165.1 29832531 1216462 complement(7213196..7216312) 1 NC_003155.4 alpha-N-acetylglucosaminidase 7216312 1216462 SAV_5988 Streptomyces avermitilis MA-4680 alpha-N-acetylglucosaminidase NP_827165.1 7213196 R 227882 CDS NP_827166.1 29832532 1216463 7216425..7216892 1 NC_003155.4 lipoprotein 7216892 1216463 SAV_5989 Streptomyces avermitilis MA-4680 lipoprotein NP_827166.1 7216425 D 227882 CDS NP_827167.1 29832533 1216464 complement(7216982..7218526) 1 NC_003155.4 protein 7218526 1216464 SAV_5990 Streptomyces avermitilis MA-4680 protein NP_827167.1 7216982 R 227882 CDS NP_827168.1 29832534 1216465 complement(7218778..7219431) 1 NC_003155.4 two-component system response regulator 7219431 1216465 SAV_5991 Streptomyces avermitilis MA-4680 two-component system response regulator NP_827168.1 7218778 R 227882 CDS NP_827169.1 29832535 1216466 complement(7219416..7220696) 1 NC_003155.4 two-component system sensor kinase 7220696 1216466 SAV_5992 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_827169.1 7219416 R 227882 CDS NP_827170.1 29832536 1216467 complement(7220796..7221815) 1 NC_003155.4 reductase 7221815 1216467 SAV_5993 Streptomyces avermitilis MA-4680 reductase NP_827170.1 7220796 R 227882 CDS NP_827171.1 29832537 1216468 complement(7221888..7222472) 1 NC_003155.4 regulatory protein 7222472 1216468 SAV_5994 Streptomyces avermitilis MA-4680 regulatory protein NP_827171.1 7221888 R 227882 CDS NP_827172.1 29832538 1216469 complement(7222592..7222801) 1 NC_003155.4 hypothetical protein 7222801 1216469 SAV_5995 Streptomyces avermitilis MA-4680 hypothetical protein NP_827172.1 7222592 R 227882 CDS NP_827173.1 29832539 1216470 complement(7222803..7223723) 1 NC_003155.4 hypothetical protein 7223723 1216470 SAV_5996 Streptomyces avermitilis MA-4680 hypothetical protein NP_827173.1 7222803 R 227882 CDS NP_827174.1 29832540 1211369 complement(7223809..7224837) 1 NC_003155.4 glutamine synthetase 7224837 glnA2 1211369 glnA2 Streptomyces avermitilis MA-4680 glutamine synthetase NP_827174.1 7223809 R 227882 CDS NP_827175.1 29832541 1216471 complement(7225433..7226128) 1 NC_003155.4 protein 7226128 1216471 SAV_5998 Streptomyces avermitilis MA-4680 protein NP_827175.1 7225433 R 227882 CDS NP_827176.1 29832542 1211370 complement(7226254..7226613) 1 NC_003155.4 arsenate reductase 7226613 arsC 1211370 arsC Streptomyces avermitilis MA-4680 arsenate reductase NP_827176.1 7226254 R 227882 CDS NP_827177.1 29832543 1216472 7226778..7227086 1 NC_003155.4 hypothetical protein 7227086 1216472 SAV_6000 Streptomyces avermitilis MA-4680 hypothetical protein NP_827177.1 7226778 D 227882 CDS NP_827178.1 29832544 1216473 complement(7227342..7229018) 1 NC_003155.4 PF01636: Phosphotransferase enzyme family; hypothetical protein 7229018 1216473 SAV_6001 Streptomyces avermitilis MA-4680 hypothetical protein NP_827178.1 7227342 R 227882 CDS NP_827179.1 29832545 1216474 complement(7229562..7230203) 1 NC_003155.4 hypothetical protein 7230203 1216474 SAV_6002 Streptomyces avermitilis MA-4680 hypothetical protein NP_827179.1 7229562 R 227882 CDS NP_827180.1 29832546 1211371 complement(7230210..7231142) 1 NC_003155.4 putative metalloprotease; heat shock protein HtpX 7231142 htpX2 1211371 htpX2 Streptomyces avermitilis MA-4680 heat shock protein HtpX NP_827180.1 7230210 R 227882 CDS NP_827181.1 29832547 1216475 7231516..7231839 1 NC_003155.4 hypothetical protein 7231839 1216475 SAV_6004 Streptomyces avermitilis MA-4680 hypothetical protein NP_827181.1 7231516 D 227882 CDS NP_827182.1 29832548 1211372 complement(7231951..7233360) 1 NC_003155.4 glutamine synthetase 7233360 glnA3 1211372 glnA3 Streptomyces avermitilis MA-4680 glutamine synthetase NP_827182.1 7231951 R 227882 CDS NP_827183.1 29832549 1216476 7233548..7234039 1 NC_003155.4 PF06271: RDD family; hypothetical protein 7234039 1216476 SAV_6006 Streptomyces avermitilis MA-4680 hypothetical protein NP_827183.1 7233548 D 227882 CDS NP_827184.1 29832550 1216477 complement(7234237..7234938) 1 NC_003155.4 integral membrane protein 7234938 1216477 SAV_6007 Streptomyces avermitilis MA-4680 integral membrane protein NP_827184.1 7234237 R 227882 CDS NP_827185.1 29832551 1216478 complement(7234998..7235195) 1 NC_003155.4 hypothetical protein 7235195 1216478 SAV_6008 Streptomyces avermitilis MA-4680 hypothetical protein NP_827185.1 7234998 R 227882 CDS NP_827186.1 29832552 1211373 complement(7235472..7236458) 1 NC_003155.4 catalyzes the radical-mediated insertion of two sulfur atoms into an ACP ACP bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 7236458 lipA 1211373 lipA Streptomyces avermitilis MA-4680 lipoyl synthase NP_827186.1 7235472 R 227882 CDS NP_827187.1 29832553 1211374 complement(7236567..7237364) 1 NC_003155.4 lipoyl-[acyl-carrier protein]-protein-N-lipoyltransferse; lipoate-protein ligase B; transfers lipoate to apolipoproteins; involved in lipoate metabolism; lipoyltransferase 7237364 lipB 1211374 lipB Streptomyces avermitilis MA-4680 lipoyltransferase NP_827187.1 7236567 R 227882 CDS NP_827188.1 29832554 1216479 7237623..7239062 1 NC_003155.4 regulatory protein 7239062 1216479 SAV_6011 Streptomyces avermitilis MA-4680 regulatory protein NP_827188.1 7237623 D 227882 CDS NP_827189.1 29832555 1216480 complement(7239200..7240597) 1 NC_003155.4 PF01593: Flavin containing amine oxidoreductase; oxidoreductase 7240597 1216480 SAV_6012 Streptomyces avermitilis MA-4680 oxidoreductase NP_827189.1 7239200 R 227882 CDS NP_827190.1 29832556 1216481 complement(7240979..7241899) 1 NC_003155.4 NAD-dependent epimerase/dehydratase family protein 7241899 1216481 SAV_6013 Streptomyces avermitilis MA-4680 NAD-dependent epimerase/dehydratase family protein NP_827190.1 7240979 R 227882 CDS NP_827191.1 29832557 1216482 7241962..7242480 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 7242480 1216482 SAV_6014 Streptomyces avermitilis MA-4680 acetyltransferase NP_827191.1 7241962 D 227882 CDS NP_827192.1 29832558 1216483 complement(7242475..7243659) 1 NC_003155.4 PF00089: Trypsin; serine protease 7243659 1216483 SAV_6015 Streptomyces avermitilis MA-4680 serine protease NP_827192.1 7242475 R 227882 CDS NP_827193.1 29832559 1216484 7243750..7244703 1 NC_003155.4 PF01510: N-acetylmuramoyl-L-alanine amidase; hypothetical protein 7244703 1216484 SAV_6016 Streptomyces avermitilis MA-4680 hypothetical protein NP_827193.1 7243750 D 227882 CDS NP_827194.1 29832560 1216485 7244790..7245017 1 NC_003155.4 hypothetical protein 7245017 1216485 SAV_6017 Streptomyces avermitilis MA-4680 hypothetical protein NP_827194.1 7244790 D 227882 CDS NP_827195.1 29832561 1216486 complement(7245052..7245573) 1 NC_003155.4 hypothetical protein 7245573 1216486 SAV_6018 Streptomyces avermitilis MA-4680 hypothetical protein NP_827195.1 7245052 R 227882 CDS NP_827196.1 29832562 1216487 complement(7245678..7246649) 1 NC_003155.4 DeoR family transcriptional regulator 7246649 1216487 SAV_6019 Streptomyces avermitilis MA-4680 DeoR family transcriptional regulator NP_827196.1 7245678 R 227882 CDS NP_827197.1 29832563 1211375 complement(7246738..7249440) 1 NC_003155.4 paralogs to the E1 component of pyruvate dehydrogenase subunit E1; 2-oxoacid dehydrogenase subunit E1 7249440 aceE2 1211375 aceE2 Streptomyces avermitilis MA-4680 2-oxoacid dehydrogenase subunit E1 NP_827197.1 7246738 R 227882 CDS NP_827198.1 29832564 1216488 complement(7249791..7250414) 1 NC_003155.4 GntR family transcriptional regulator 7250414 1216488 SAV_6021 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_827198.1 7249791 R 227882 CDS NP_827199.1 29832565 1211376 complement(7250648..7252471) 1 NC_003155.4 dihydrolipoamide S-succinyltransferase 7252471 sucB 1211376 sucB Streptomyces avermitilis MA-4680 dihydrolipoamide S-succinyltransferase NP_827199.1 7250648 R 227882 CDS NP_827200.2 57833863 1211377 complement(7252581..7253969) 1 NC_003155.4 E3 component of pyruvate complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 7253969 lpdA1 1211377 lpdA1 Streptomyces avermitilis MA-4680 dihydrolipoamide dehydrogenase NP_827200.2 7252581 R 227882 CDS NP_827201.1 29832567 1216489 complement(7254268..7255809) 1 NC_003155.4 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 7255809 1216489 SAV_6025 Streptomyces avermitilis MA-4680 leucyl aminopeptidase NP_827201.1 7254268 R 227882 CDS NP_827202.1 29832568 1211378 complement(7256211..7256993) 1 NC_003155.4 cobalamin biosynthesis; cobalamin (5'-phosphate) synthase 7256993 cobS 1211378 cobS Streptomyces avermitilis MA-4680 cobalamin (5'-phosphate) synthase NP_827202.1 7256211 R 227882 CDS NP_827203.1 29832569 1216490 7257067..7257831 1 NC_003155.4 PF00499: NADH-ubiquinone/plastoquinone oxidoreductase chain 6; integral membrane protein 7257831 1216490 SAV_6027 Streptomyces avermitilis MA-4680 integral membrane protein NP_827203.1 7257067 D 227882 CDS NP_827204.1 29832570 1216491 complement(7257812..7258483) 1 NC_003155.4 integral membrane protein 7258483 1216491 SAV_6028 Streptomyces avermitilis MA-4680 integral membrane protein NP_827204.1 7257812 R 227882 CDS NP_827205.1 29832571 1216492 complement(7258540..7260474) 1 NC_003155.4 PF04329: Family of unknown function (DUF470); integral membrane protein 7260474 1216492 SAV_6029 Streptomyces avermitilis MA-4680 integral membrane protein NP_827205.1 7258540 R 227882 CDS NP_827206.1 29832572 1211379 complement(7260693..7261820) 1 NC_003155.4 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 7261820 cobT 1211379 cobT Streptomyces avermitilis MA-4680 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase NP_827206.1 7260693 R 227882 CDS NP_827207.1 29832573 1216493 7261933..7263144 1 NC_003155.4 hypothetical protein 7263144 1216493 SAV_6031 Streptomyces avermitilis MA-4680 hypothetical protein NP_827207.1 7261933 D 227882 CDS NP_827208.1 29832574 1216494 complement(7263206..7264525) 1 NC_003155.4 cobalamin biosynthesis; adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase 7264525 cobU 1216494 cobU Streptomyces avermitilis MA-4680 adenosylcobinamide kinase/adenosylcobinamide phosphate guanylyltransferase NP_827208.1 7263206 R 227882 CDS NP_827209.1 29832575 1216495 7264667..7264891 1 NC_003155.4 hypothetical protein 7264891 1216495 SAV_6033 Streptomyces avermitilis MA-4680 hypothetical protein NP_827209.1 7264667 D 227882 CDS NP_827210.1 29832576 1216496 complement(7264991..7265704) 1 NC_003155.4 methyltransferase 7265704 1216496 SAV_6034 Streptomyces avermitilis MA-4680 methyltransferase NP_827210.1 7264991 R 227882 CDS NP_827211.1 29832577 1216497 complement(7265788..7266414) 1 NC_003155.4 integral membrane protein 7266414 1216497 SAV_6035 Streptomyces avermitilis MA-4680 integral membrane protein NP_827211.1 7265788 R 227882 CDS NP_827212.1 29832578 1216498 7266712..7267482 1 NC_003155.4 phage shock protein A 7267482 1216498 SAV_6036 Streptomyces avermitilis MA-4680 phage shock protein A NP_827212.1 7266712 D 227882 CDS NP_827213.1 29832579 1216499 7267507..7267785 1 NC_003155.4 hypothetical protein 7267785 1216499 SAV_6037 Streptomyces avermitilis MA-4680 hypothetical protein NP_827213.1 7267507 D 227882 CDS NP_827214.1 29832580 1216500 7268025..7269245 1 NC_003155.4 two-component system sensor kinase 7269245 1216500 SAV_6038 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_827214.1 7268025 D 227882 CDS NP_827215.1 29832581 1216501 7269242..7269925 1 NC_003155.4 two-component system response regulator 7269925 1216501 SAV_6039 Streptomyces avermitilis MA-4680 two-component system response regulator NP_827215.1 7269242 D 227882 CDS NP_827216.1 29832582 1216502 7270082..7273243 1 NC_003155.4 involving efflux of acriflavin-related compounds, PF00873: AcrB/AcrD/AcrF family; cation/multidrug efflux protein 7273243 1216502 SAV_6040 Streptomyces avermitilis MA-4680 cation/multidrug efflux protein NP_827216.1 7270082 D 227882 CDS NP_827217.1 29832583 1211380 complement(7273374..7274618) 1 NC_003155.4 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 7274618 nadA 1211380 nadA Streptomyces avermitilis MA-4680 quinolinate synthetase NP_827217.1 7273374 R 227882 CDS NP_827218.1 29832584 1216503 7274893..7275249 1 NC_003155.4 PF01521: HesB-like domain; hypothetical protein 7275249 1216503 SAV_6042 Streptomyces avermitilis MA-4680 hypothetical protein NP_827218.1 7274893 D 227882 CDS NP_827219.1 29832585 1216504 complement(7275456..7276913) 1 NC_003155.4 PF04886: PT repeat; hypothetical protein 7276913 1216504 SAV_6043 Streptomyces avermitilis MA-4680 hypothetical protein NP_827219.1 7275456 R 227882 CDS NP_827220.1 29832586 1216505 complement(7277491..7277700) 1 NC_003155.4 hypothetical protein 7277700 1216505 SAV_6044 Streptomyces avermitilis MA-4680 hypothetical protein NP_827220.1 7277491 R 227882 CDS NP_827221.1 29832587 1216506 7277792..7278808 1 NC_003155.4 carbohydrate kinase 7278808 1216506 SAV_6045 Streptomyces avermitilis MA-4680 carbohydrate kinase NP_827221.1 7277792 D 227882 CDS NP_827222.1 29832588 1216507 complement(7278844..7280226) 1 NC_003155.4 aminotransferase 7280226 1216507 SAV_6046 Streptomyces avermitilis MA-4680 aminotransferase NP_827222.1 7278844 R 227882 CDS NP_827223.1 29832589 1211381 7280555..7281514 1 NC_003155.4 cytochrome c oxidase subunit II 7281514 ctaC 1211381 ctaC Streptomyces avermitilis MA-4680 cytochrome c oxidase subunit II NP_827223.1 7280555 D 227882 CDS NP_827224.1 29832590 1211382 7281511..7283250 1 NC_003155.4 cytochrome c oxidase subunit I 7283250 ctaD1 1211382 ctaD1 Streptomyces avermitilis MA-4680 cytochrome c oxidase subunit I NP_827224.1 7281511 D 227882 CDS NP_827225.1 29832591 1216508 7283247..7283645 1 NC_003155.4 integral membrane protein 7283645 1216508 SAV_6049 Streptomyces avermitilis MA-4680 integral membrane protein NP_827225.1 7283247 D 227882 CDS NP_827226.1 29832592 1216509 7283820..7285085 1 NC_003155.4 PF03734: ErfK/YbiS/YcfS/YnhG; lipoprotein 7285085 lppS 1216509 lppS Streptomyces avermitilis MA-4680 lipoprotein NP_827226.1 7283820 D 227882 CDS NP_827227.1 29832593 1216510 complement(7285142..7285540) 1 NC_003155.4 two-component system response regulator 7285540 1216510 SAV_6051 Streptomyces avermitilis MA-4680 two-component system response regulator NP_827227.1 7285142 R 227882 CDS NP_827228.1 29832594 1211383 7285719..7286339 1 NC_003155.4 cytochrome c oxidase subunit III 7286339 ctaE 1211383 ctaE Streptomyces avermitilis MA-4680 cytochrome c oxidase subunit III NP_827228.1 7285719 D 227882 CDS NP_827229.1 29832595 1211384 7286403..7287212 1 NC_003155.4 cytochrome c heme-binding subunit 7287212 qcrC 1211384 qcrC Streptomyces avermitilis MA-4680 cytochrome c heme-binding subunit NP_827229.1 7286403 D 227882 CDS NP_827230.1 29832596 1211385 7287209..7288282 1 NC_003155.4 ubiquinol-cytochrome c reductase iron-sulphur 'Rieske' subunit 7288282 qcrA 1211385 qcrA Streptomyces avermitilis MA-4680 ubiquinol-cytochrome c reductase iron-sulphur 'Rieske' subunit NP_827230.1 7287209 D 227882 CDS NP_827231.1 29832597 1211386 7288279..7289925 1 NC_003155.4 cytochrome b subunit 7289925 qcrB1 1211386 qcrB1 Streptomyces avermitilis MA-4680 cytochrome b subunit NP_827231.1 7288279 D 227882 CDS NP_827232.1 29832598 1211387 7290084..7291148 1 NC_003155.4 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 7291148 trpD 1211387 trpD Streptomyces avermitilis MA-4680 anthranilate phosphoribosyltransferase NP_827232.1 7290084 D 227882 CDS NP_827233.1 29832599 1216511 7291526..7292899 1 NC_003155.4 aminotransferase 7292899 1216511 SAV_6057 Streptomyces avermitilis MA-4680 aminotransferase NP_827233.1 7291526 D 227882 CDS NP_827234.1 29832600 1216512 complement(7292926..7293207) 1 NC_003155.4 transcriptional regulator 7293207 1216512 SAV_6058 Streptomyces avermitilis MA-4680 transcriptional regulator NP_827234.1 7292926 R 227882 CDS NP_827235.1 29832601 1216513 complement(7293204..7293947) 1 NC_003155.4 PF01694: Rhomboid family; integral membrane protein 7293947 1216513 SAV_6059 Streptomyces avermitilis MA-4680 integral membrane protein NP_827235.1 7293204 R 227882 CDS NP_827236.1 29832602 1216514 7294035..7294313 1 NC_003155.4 hypothetical protein 7294313 1216514 SAV_6060 Streptomyces avermitilis MA-4680 hypothetical protein NP_827236.1 7294035 D 227882 CDS NP_827237.1 29832603 1216515 7294349..7295698 1 NC_003155.4 PF05991: Protein of unknown function (DUF901); hypothetical protein 7295698 1216515 SAV_6061 Streptomyces avermitilis MA-4680 hypothetical protein NP_827237.1 7294349 D 227882 CDS NP_827238.1 29832604 1216516 7296036..7297076 1 NC_003155.4 NLP/P60-family protein 7297076 1216516 SAV_6062 Streptomyces avermitilis MA-4680 NLP/P60-family protein NP_827238.1 7296036 D 227882 CDS NP_827239.1 29832605 1216517 7297300..7298313 1 NC_003155.4 NPL/P60-family protein 7298313 1216517 SAV_6063 Streptomyces avermitilis MA-4680 NPL/P60-family protein NP_827239.1 7297300 D 227882 CDS NP_827240.1 29832606 1216518 7298336..7299556 1 NC_003155.4 hypothetical protein 7299556 1216518 SAV_6064 Streptomyces avermitilis MA-4680 hypothetical protein NP_827240.1 7298336 D 227882 CDS NP_827241.1 29832607 1216519 7299741..7301087 1 NC_003155.4 transporter 7301087 1216519 SAV_6065 Streptomyces avermitilis MA-4680 transporter NP_827241.1 7299741 D 227882 CDS NP_827242.1 29832608 1216520 complement(7301048..7302280) 1 NC_003155.4 hypothetical protein 7302280 1216520 SAV_6066 Streptomyces avermitilis MA-4680 hypothetical protein NP_827242.1 7301048 R 227882 CDS NP_827243.1 29832609 1216521 7302443..7303585 1 NC_003155.4 PF00534: Glycosyl transferases group 1; glycosyl transferase 7303585 1216521 SAV_6067 Streptomyces avermitilis MA-4680 glycosyl transferase NP_827243.1 7302443 D 227882 CDS NP_827244.1 29832610 1216522 7303865..7305499 1 NC_003155.4 PF05199: GMC oxidoreductase; cholesterol oxidase 7305499 1216522 SAV_6068 Streptomyces avermitilis MA-4680 cholesterol oxidase NP_827244.1 7303865 D 227882 CDS NP_827245.1 29832611 1211388 complement(7305519..7307315) 1 NC_003155.4 PF00501: AMP-binding enzyme; acyl-CoA synthetase, long-chain fatty acid:CoA ligase 7307315 fadD14 1211388 fadD14 Streptomyces avermitilis MA-4680 acyl-CoA synthetase, long-chain fatty acid:CoA ligase NP_827245.1 7305519 R 227882 CDS NP_827246.1 29832612 1216523 7307611..7308408 1 NC_003155.4 PF00149: Calcineurin-like phosphoesterase; hypothetical protein 7308408 1216523 SAV_6070 Streptomyces avermitilis MA-4680 hypothetical protein NP_827246.1 7307611 D 227882 CDS NP_827247.1 29832613 1216524 7308543..7308986 1 NC_003155.4 hypothetical protein 7308986 1216524 SAV_6071 Streptomyces avermitilis MA-4680 hypothetical protein NP_827247.1 7308543 D 227882 CDS NP_827248.1 29832614 1216525 7309096..7310265 1 NC_003155.4 PF02374: Anion-transporting ATPase; ion transporting ATPase 7310265 1216525 SAV_6072 Streptomyces avermitilis MA-4680 ion transporting ATPase NP_827248.1 7309096 D 227882 CDS NP_827249.1 29832615 1216526 7310369..7310884 1 NC_003155.4 hypothetical protein 7310884 1216526 SAV_6073 Streptomyces avermitilis MA-4680 hypothetical protein NP_827249.1 7310369 D 227882 CDS NP_827250.1 29832616 1211389 7310940..7311893 1 NC_003155.4 glucokinase 7311893 glkA1 1211389 glkA1 Streptomyces avermitilis MA-4680 glucokinase NP_827250.1 7310940 D 227882 CDS NP_827251.1 29832617 1216527 7311988..7312761 1 NC_003155.4 PF03372: Endonuclease/Exonuclease/phosphatase family; hypothetical protein 7312761 1216527 SAV_6075 Streptomyces avermitilis MA-4680 hypothetical protein NP_827251.1 7311988 D 227882 CDS NP_827252.1 29832618 1216528 complement(7312758..7313819) 1 NC_003155.4 hypothetical protein 7313819 1216528 SAV_6076 Streptomyces avermitilis MA-4680 hypothetical protein NP_827252.1 7312758 R 227882 CDS NP_827253.1 29832619 1211390 complement(7313773..7314393) 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 7314393 sig49 1211390 sig49 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_827253.1 7313773 R 227882 CDS NP_827254.1 29832620 1216529 complement(7314664..7315308) 1 NC_003155.4 hypothetical protein 7315308 1216529 SAV_6078 Streptomyces avermitilis MA-4680 hypothetical protein NP_827254.1 7314664 R 227882 CDS NP_827255.1 29832621 1216530 complement(7315301..7316218) 1 NC_003155.4 esterase/lipase 7316218 1216530 SAV_6079 Streptomyces avermitilis MA-4680 esterase/lipase NP_827255.1 7315301 R 227882 CDS NP_827256.1 29832622 1211391 7316297..7317079 1 NC_003155.4 1-acylglycerol-3-phosphate O-acyltransferase 7317079 plsC3 1211391 plsC3 Streptomyces avermitilis MA-4680 1-acylglycerol-3-phosphate O-acyltransferase NP_827256.1 7316297 D 227882 CDS NP_827257.1 29832623 1216531 7317110..7318342 1 NC_003155.4 two-component system sensor kinase 7318342 1216531 SAV_6081 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_827257.1 7317110 D 227882 CDS NP_827258.1 29832624 1216532 7318369..7319016 1 NC_003155.4 two-component system response regulator 7319016 1216532 SAV_6082 Streptomyces avermitilis MA-4680 two-component system response regulator NP_827258.1 7318369 D 227882 CDS NP_827259.1 29832625 1211392 7319161..7320189 1 NC_003155.4 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 7320189 pfkA2 1211392 pfkA2 Streptomyces avermitilis MA-4680 6-phosphofructokinase NP_827259.1 7319161 D 227882 CDS NP_827260.1 29832626 1211393 complement(7320283..7322268) 1 NC_003155.4 anthranilate/para-aminobenzoate synthase component I 7322268 phzE 1211393 phzE Streptomyces avermitilis MA-4680 anthranilate/para-aminobenzoate synthase component I NP_827260.1 7320283 R 227882 CDS NP_827261.1 29832627 1216533 7322604..7323869 1 NC_003155.4 hypothetical protein 7323869 1216533 SAV_6085 Streptomyces avermitilis MA-4680 hypothetical protein NP_827261.1 7322604 D 227882 CDS NP_827262.1 29832628 1211394 7323905..7325257 1 NC_003155.4 EC:2.5.1.54, DAHP synthase; 2-dehydro-3-deoxyphosphoheptonate aldolase 7325257 aroG 1211394 aroG Streptomyces avermitilis MA-4680 2-dehydro-3-deoxyphosphoheptonate aldolase NP_827262.1 7323905 D 227882 CDS NP_827263.1 29832629 1216534 7325434..7325697 1 NC_003155.4 PF04324: BFD-like [2Fe-2S] binding domain; hypothetical protein 7325697 1216534 SAV_6087 Streptomyces avermitilis MA-4680 hypothetical protein NP_827263.1 7325434 D 227882 CDS NP_827264.1 29832630 1211395 complement(7325739..7326218) 1 NC_003155.4 bacterioferritin 7326218 bfrA 1211395 bfrA Streptomyces avermitilis MA-4680 bacterioferritin NP_827264.1 7325739 R 227882 CDS NP_827265.1 29832631 1216535 7326374..7327006 1 NC_003155.4 PF00174: Oxidoreductase molybdopterin binding domain; hypothetical protein 7327006 1216535 SAV_6089 Streptomyces avermitilis MA-4680 hypothetical protein NP_827265.1 7326374 D 227882 CDS NP_827266.1 29832632 1216536 complement(7327035..7327631) 1 NC_003155.4 hypothetical protein 7327631 1216536 SAV_6090 Streptomyces avermitilis MA-4680 hypothetical protein NP_827266.1 7327035 R 227882 CDS NP_827267.1 29832633 1211396 complement(7327680..7328612) 1 NC_003155.4 endonuclease IV 7328612 nfo 1211396 nfo Streptomyces avermitilis MA-4680 endonuclease IV NP_827267.1 7327680 R 227882 CDS NP_827268.1 29832634 1211397 complement(7328671..7330617) 1 NC_003155.4 serine/threonine protein kinase 7330617 pkn28 1211397 pkn28 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_827268.1 7328671 R 227882 CDS NP_827269.1 29832635 1211398 complement(7330683..7331477) 1 NC_003155.4 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 7331477 thiG 1211398 thiG Streptomyces avermitilis MA-4680 thiazole synthase NP_827269.1 7330683 R 227882 CDS NP_827270.1 29832636 1216537 complement(7331481..7331681) 1 NC_003155.4 PF02597: ThiS family; thiamine biosynthesis sulfur transfer protein 7331681 thiS 1216537 thiS Streptomyces avermitilis MA-4680 thiamine biosynthesis sulfur transfer protein NP_827270.1 7331481 R 227882 CDS NP_827271.1 29832637 1211399 complement(7331678..7332844) 1 NC_003155.4 glycine oxidase 7332844 goxB 1211399 goxB Streptomyces avermitilis MA-4680 glycine oxidase NP_827271.1 7331678 R 227882 CDS NP_827272.1 29832638 1216538 7332974..7333357 1 NC_003155.4 hypothetical protein 7333357 1216538 SAV_6096 Streptomyces avermitilis MA-4680 hypothetical protein NP_827272.1 7332974 D 227882 CDS NP_827273.1 29832639 1211400 7333390..7334619 1 NC_003155.4 ferredoxin reductase 7334619 fprE 1211400 fprE Streptomyces avermitilis MA-4680 ferredoxin reductase NP_827273.1 7333390 D 227882 CDS NP_827274.1 29832640 1216539 7334766..7335131 1 NC_003155.4 transcriptional regulatory protein 7335131 1216539 SAV_6098 Streptomyces avermitilis MA-4680 transcriptional regulatory protein NP_827274.1 7334766 D 227882 CDS NP_827275.1 29832641 1211401 7335277..7335954 1 NC_003155.4 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 7335954 thiE 1211401 thiE Streptomyces avermitilis MA-4680 thiamine-phosphate pyrophosphorylase NP_827275.1 7335277 D 227882 CDS NP_827276.1 29832642 1211402 7336079..7337002 1 NC_003155.4 5,10-methylenetetrahydrofolate reductase 7337002 metF 1211402 metF Streptomyces avermitilis MA-4680 5,10-methylenetetrahydrofolate reductase NP_827276.1 7336079 D 227882 CDS NP_827277.1 29832643 1216540 7337059..7337976 1 NC_003155.4 hypothetical protein 7337976 1216540 SAV_6101 Streptomyces avermitilis MA-4680 hypothetical protein NP_827277.1 7337059 D 227882 CDS NP_827278.1 29832644 1211403 complement(7338078..7339571) 1 NC_003155.4 phytoene dehydrogenase 7339571 crtI2 1211403 crtI2 Streptomyces avermitilis MA-4680 phytoene dehydrogenase NP_827278.1 7338078 R 227882 CDS NP_827279.1 29832645 1216541 complement(7339617..7340270) 1 NC_003155.4 hypothetical protein 7340270 1216541 SAV_6103 Streptomyces avermitilis MA-4680 hypothetical protein NP_827279.1 7339617 R 227882 CDS NP_827280.1 29832646 1216542 complement(7340634..7341317) 1 NC_003155.4 TetR family transcriptional regulator 7341317 1216542 SAV_6104 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_827280.1 7340634 R 227882 CDS NP_827281.1 29832647 1216543 complement(7341314..7343398) 1 NC_003155.4 PF01061: ABC-2 type transporter; hypothetical protein 7343398 1216543 SAV_6105 Streptomyces avermitilis MA-4680 hypothetical protein NP_827281.1 7341314 R 227882 CDS NP_827282.1 29832648 1216544 complement(7343370..7344392) 1 NC_003155.4 ABC transporter ATP-binding protein 7344392 1216544 SAV_6106 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_827282.1 7343370 R 227882 CDS NP_827283.1 29832649 1216545 7344573..7345121 1 NC_003155.4 hypothetical protein 7345121 1216545 SAV_6107 Streptomyces avermitilis MA-4680 hypothetical protein NP_827283.1 7344573 D 227882 CDS NP_827284.1 29832650 1216546 7345418..7346188 1 NC_003155.4 methyltransferase 7346188 1216546 SAV_6108 Streptomyces avermitilis MA-4680 methyltransferase NP_827284.1 7345418 D 227882 CDS NP_827285.1 29832651 1216547 7346464..7346856 1 NC_003155.4 hypothetical protein 7346856 1216547 SAV_6109 Streptomyces avermitilis MA-4680 hypothetical protein NP_827285.1 7346464 D 227882 CDS NP_827286.1 29832652 1216548 complement(7347246..7349633) 1 NC_003155.4 PF01841: Transglutaminase-like superfamily; hypothetical protein 7349633 1216548 SAV_6110 Streptomyces avermitilis MA-4680 hypothetical protein NP_827286.1 7347246 R 227882 CDS NP_827287.1 29832653 1216549 complement(7349630..7350991) 1 NC_003155.4 PF01882: Protein of unknown function DUF58; hypothetical protein 7350991 1216549 SAV_6111 Streptomyces avermitilis MA-4680 hypothetical protein NP_827287.1 7349630 R 227882 CDS NP_827288.1 29832654 1216550 complement(7350988..7352019) 1 NC_003155.4 regulatory protein 7352019 1216550 SAV_6112 Streptomyces avermitilis MA-4680 regulatory protein NP_827288.1 7350988 R 227882 CDS NP_827289.1 29832655 1216551 complement(7352267..7352815) 1 NC_003155.4 plant-type carbonic anhydrase 7352815 1216551 SAV_6113 Streptomyces avermitilis MA-4680 plant-type carbonic anhydrase NP_827289.1 7352267 R 227882 CDS NP_827290.1 29832656 1216552 7353263..7354219 1 NC_003155.4 S-adenosyl-methyltransferase MraW 7354219 mraW 1216552 mraW Streptomyces avermitilis MA-4680 S-adenosyl-methyltransferase MraW NP_827290.1 7353263 D 227882 CDS NP_827291.1 29832657 1216553 7354230..7354757 1 NC_003155.4 PF04977: Septum formation initiator; hypothetical protein 7354757 1216553 SAV_6115 Streptomyces avermitilis MA-4680 hypothetical protein NP_827291.1 7354230 D 227882 CDS NP_827292.1 29832658 1211404 7354754..7356715 1 NC_003155.4 PF00905: Penicillin binding protein transpeptidase domain; cell division protein FtsI/penicillin-binding protein 7356715 ftsI 1211404 ftsI Streptomyces avermitilis MA-4680 cell division protein FtsI/penicillin-binding protein NP_827292.1 7354754 D 227882 CDS NP_827293.1 29832659 1211405 7356881..7358401 1 NC_003155.4 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 7358401 murE 1211405 murE Streptomyces avermitilis MA-4680 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase NP_827293.1 7356881 D 227882 CDS NP_827294.1 29832660 1211406 7358406..7359821 1 NC_003155.4 UDP-N-acetylmuramoylalanyl-D-glutamyl- 2,6-diaminopimelate-D-alanyl-D-alanine ligase 7359821 murF 1211406 murF Streptomyces avermitilis MA-4680 UDP-N-acetylmuramoylalanyl-D-glutamyl- 2,6-diaminopimelate-D-alanyl-D-alanine ligase NP_827294.1 7358406 D 227882 CDS NP_827295.1 29832661 1211407 7359818..7360891 1 NC_003155.4 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 7360891 mraY 1211407 mraY Streptomyces avermitilis MA-4680 phospho-N-acetylmuramoyl-pentapeptide- transferase NP_827295.1 7359818 D 227882 CDS NP_827296.1 29832662 1211408 7360888..7362291 1 NC_003155.4 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 7362291 murD 1211408 murD Streptomyces avermitilis MA-4680 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase NP_827296.1 7360888 D 227882 CDS NP_827297.1 29832663 1211409 7362356..7363705 1 NC_003155.4 PF01098: Cell cycle protein; cell division membrane protein FtsW 7363705 ftsW1 1211409 ftsW1 Streptomyces avermitilis MA-4680 cell division membrane protein FtsW NP_827297.1 7362356 D 227882 CDS NP_827298.1 29832664 1211410 7363712..7364803 1 NC_003155.4 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; UDPdiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 7364803 murG 1211410 murG Streptomyces avermitilis MA-4680 UDPdiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase NP_827298.1 7363712 D 227882 CDS NP_827299.1 29832665 1211411 7365019..7365810 1 NC_003155.4 cell division septal protein FtsQ 7365810 ftsQ 1211411 ftsQ Streptomyces avermitilis MA-4680 cell division septal protein FtsQ NP_827299.1 7365019 D 227882 CDS NP_827300.1 29832666 1211412 7366087..7367277 1 NC_003155.4 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 7367277 ftsZ 1211412 ftsZ Streptomyces avermitilis MA-4680 cell division protein FtsZ NP_827300.1 7366087 D 227882 CDS NP_827301.1 29832667 1216554 7367274..7368002 1 NC_003155.4 PF02578: Uncharacterised ACR, YfiH family COG1496; hypothetical protein 7368002 1216554 SAV_6125 Streptomyces avermitilis MA-4680 hypothetical protein NP_827301.1 7367274 D 227882 CDS NP_827302.1 29832668 1216555 7368009..7368728 1 NC_003155.4 PF01168: Alanine racemase, N-terminal domain; hypothetical protein 7368728 1216555 SAV_6126 Streptomyces avermitilis MA-4680 hypothetical protein NP_827302.1 7368009 D 227882 CDS NP_827303.1 29832669 1216556 7368859..7369500 1 NC_003155.4 PF04472: Protein of unknown function (DUF552); hypothetical protein 7369500 1216556 SAV_6127 Streptomyces avermitilis MA-4680 hypothetical protein NP_827303.1 7368859 D 227882 CDS NP_827304.1 29832670 1216557 7369552..7369836 1 NC_003155.4 PF02325: YGGT family; hypothetical protein 7369836 1216557 SAV_6128 Streptomyces avermitilis MA-4680 hypothetical protein NP_827304.1 7369552 D 227882 CDS NP_827305.1 29832671 1216558 7369883..7371109 1 NC_003155.4 PF05103: DivIVA protein; hypothetical protein 7371109 1216558 SAV_6129 Streptomyces avermitilis MA-4680 hypothetical protein NP_827305.1 7369883 D 227882 CDS NP_827306.1 29832672 1211413 complement(7371348..7374491) 1 NC_003155.4 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin); isoleucyl-tRNA synthetase 7374491 ileS 1211413 ileS Streptomyces avermitilis MA-4680 isoleucyl-tRNA synthetase NP_827306.1 7371348 R 227882 CDS NP_827307.1 29832673 1216559 7375244..7376314 1 NC_003155.4 DNA-binding protein 7376314 1216559 SAV_6131 Streptomyces avermitilis MA-4680 DNA-binding protein NP_827307.1 7375244 D 227882 CDS NP_827308.1 29832674 1216560 7376393..7376995 1 NC_003155.4 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 7376995 lspA 1216560 lspA Streptomyces avermitilis MA-4680 lipoprotein signal peptidase NP_827308.1 7376393 D 227882 CDS NP_827309.1 29832675 1216561 7377080..7378024 1 NC_003155.4 ribosomal large subunit pseudouridine synthase 7378024 1216561 SAV_6133 Streptomyces avermitilis MA-4680 ribosomal large subunit pseudouridine synthase NP_827309.1 7377080 D 227882 CDS NP_827310.1 29832676 1216562 complement(7378015..7378506) 1 NC_003155.4 hypothetical protein 7378506 1216562 SAV_6134 Streptomyces avermitilis MA-4680 hypothetical protein NP_827310.1 7378015 R 227882 CDS NP_827311.1 29832677 1216563 7378547..7380142 1 NC_003155.4 PF00999: Sodium/hydrogen exchanger family; sodium/proton antiporter 7380142 1216563 SAV_6135 Streptomyces avermitilis MA-4680 sodium/proton antiporter NP_827311.1 7378547 D 227882 CDS NP_827312.1 29832678 1211414 7380357..7381097 1 NC_003155.4 PF00106: short chain dehydrogenase; 3-oxoacyl-ACP reductase 7381097 fabG6 1211414 fabG6 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP reductase NP_827312.1 7380357 D 227882 CDS NP_827313.1 29832679 1216564 complement(7381221..7382324) 1 NC_003155.4 PF00924: Mechanosensitive ion channel; hypothetical protein 7382324 1216564 SAV_6137 Streptomyces avermitilis MA-4680 hypothetical protein NP_827313.1 7381221 R 227882 CDS NP_827314.1 29832680 1216565 7382444..7383013 1 NC_003155.4 PF01738: Dienelactone hydrolase family; hypothetical protein 7383013 1216565 SAV_6138 Streptomyces avermitilis MA-4680 hypothetical protein NP_827314.1 7382444 D 227882 CDS NP_827315.1 29832681 1216566 complement(7383111..7384772) 1 NC_003155.4 alkaline phosphatase 7384772 phoD1 1216566 phoD1 Streptomyces avermitilis MA-4680 alkaline phosphatase NP_827315.1 7383111 R 227882 CDS NP_827316.1 29832682 1216567 complement(7384871..7385710) 1 NC_003155.4 PF01323: DSBA-like thioredoxin domain; hypothetical protein 7385710 1216567 SAV_6140 Streptomyces avermitilis MA-4680 hypothetical protein NP_827316.1 7384871 R 227882 CDS NP_827317.1 29832683 1216568 complement(7385777..7386463) 1 NC_003155.4 hypothetical protein 7386463 1216568 SAV_6141 Streptomyces avermitilis MA-4680 hypothetical protein NP_827317.1 7385777 R 227882 CDS NP_827318.1 29832684 1216569 complement(7386532..7387857) 1 NC_003155.4 hypothetical protein 7387857 1216569 SAV_6142 Streptomyces avermitilis MA-4680 hypothetical protein NP_827318.1 7386532 R 227882 CDS NP_827319.1 29832685 1211415 7388156..7391695 1 NC_003155.4 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 7391695 dnaE 1211415 dnaE Streptomyces avermitilis MA-4680 DNA polymerase III subunit alpha NP_827319.1 7388156 D 227882 CDS NP_827320.1 29832686 1216570 complement(7391829..7392008) 1 NC_003155.4 hypothetical protein 7392008 1216570 SAV_6144 Streptomyces avermitilis MA-4680 hypothetical protein NP_827320.1 7391829 R 227882 CDS NP_827321.1 29832687 1216571 7392224..7393450 1 NC_003155.4 PF01936: Protein of unknown function DUF88; hypothetical protein 7393450 1216571 SAV_6145 Streptomyces avermitilis MA-4680 hypothetical protein NP_827321.1 7392224 D 227882 CDS NP_827322.1 29832688 1216572 7393410..7394549 1 NC_003155.4 ABC transporter ATP-binding protein 7394549 1216572 SAV_6146 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_827322.1 7393410 D 227882 CDS NP_827323.1 29832689 1216573 7394581..7395435 1 NC_003155.4 ABC transporter integral membrane transport protein 7395435 1216573 SAV_6147 Streptomyces avermitilis MA-4680 ABC transporter integral membrane transport protein NP_827323.1 7394581 D 227882 CDS NP_827324.1 29832690 1216574 7395470..7396135 1 NC_003155.4 hypothetical protein 7396135 1216574 SAV_6148 Streptomyces avermitilis MA-4680 hypothetical protein NP_827324.1 7395470 D 227882 CDS NP_827325.1 29832691 1216575 complement(7396385..7396885) 1 NC_003155.4 transcriptional regulator 7396885 1216575 SAV_6149 Streptomyces avermitilis MA-4680 transcriptional regulator NP_827325.1 7396385 R 227882 CDS NP_827326.1 29832692 1216576 complement(7396909..7397649) 1 NC_003155.4 PF02190: ATP-dependent protease La (LON) domain; hypothetical protein 7397649 1216576 SAV_6150 Streptomyces avermitilis MA-4680 hypothetical protein NP_827326.1 7396909 R 227882 CDS NP_827327.1 29832693 1216577 complement(7397661..7398749) 1 NC_003155.4 hypothetical protein 7398749 1216577 SAV_6151 Streptomyces avermitilis MA-4680 hypothetical protein NP_827327.1 7397661 R 227882 CDS NP_827328.1 29832694 1216578 complement(7398901..7400481) 1 NC_003155.4 hypothetical protein 7400481 1216578 SAV_6152 Streptomyces avermitilis MA-4680 hypothetical protein NP_827328.1 7398901 R 227882 CDS NP_827329.1 29832695 1211416 7400715..7402040 1 NC_003155.4 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 7402040 hisD 1211416 hisD Streptomyces avermitilis MA-4680 histidinol dehydrogenase NP_827329.1 7400715 D 227882 CDS NP_827330.1 29832696 1211417 7402037..7403146 1 NC_003155.4 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 7403146 hisC1 1211417 hisC1 Streptomyces avermitilis MA-4680 histidinol-phosphate aminotransferase NP_827330.1 7402037 D 227882 CDS NP_827331.1 29832697 1211418 7403143..7403736 1 NC_003155.4 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; imidazoleglycerol-phosphate dehydratase 7403736 hisB 1211418 hisB Streptomyces avermitilis MA-4680 imidazoleglycerol-phosphate dehydratase NP_827331.1 7403143 D 227882 CDS NP_827332.1 29832698 1216579 7403733..7403897 1 NC_003155.4 hypothetical protein 7403897 1216579 SAV_6156 Streptomyces avermitilis MA-4680 hypothetical protein NP_827332.1 7403733 D 227882 CDS NP_827333.1 29832699 1211419 7403888..7404535 1 NC_003155.4 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 7404535 hisH 1211419 hisH Streptomyces avermitilis MA-4680 imidazole glycerol phosphate synthase subunit HisH NP_827333.1 7403888 D 227882 CDS NP_827334.1 29832700 1211420 7404535..7405263 1 NC_003155.4 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis; phosphoribosyl isomerase A 7405263 hisA 1211420 hisA Streptomyces avermitilis MA-4680 phosphoribosyl isomerase A NP_827334.1 7404535 D 227882 CDS NP_827335.1 29832701 1216580 7405326..7405658 1 NC_003155.4 PF01042: Endoribonuclease L-PSP; hypothetical protein 7405658 1216580 SAV_6159 Streptomyces avermitilis MA-4680 hypothetical protein NP_827335.1 7405326 D 227882 CDS NP_827336.1 29832702 1211421 7405655..7406410 1 NC_003155.4 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 7406410 hisF 1211421 hisF Streptomyces avermitilis MA-4680 imidazole glycerol phosphate synthase subunit HisF NP_827336.1 7405655 D 227882 CDS NP_827337.1 29832703 1216581 7406528..7407115 1 NC_003155.4 transcription regulator ArsR 7407115 1216581 SAV_6161 Streptomyces avermitilis MA-4680 transcription regulator ArsR NP_827337.1 7406528 D 227882 CDS NP_827338.1 29832704 1216582 7407247..7408479 1 NC_003155.4 PF07690: Major Facilitator Superfamily; integral membrane efflux protein 7408479 1216582 SAV_6162 Streptomyces avermitilis MA-4680 integral membrane efflux protein NP_827338.1 7407247 D 227882 CDS NP_827339.1 29832705 1216583 7409008..7410264 1 NC_003155.4 regulatory protein 7410264 1216583 SAV_6163 Streptomyces avermitilis MA-4680 regulatory protein NP_827339.1 7409008 D 227882 CDS NP_827340.1 29832706 1216584 7410741..7411832 1 NC_003155.4 branched-chain amino acid ABC transporter ATP-binding protein 7411832 1216584 SAV_6164 Streptomyces avermitilis MA-4680 branched-chain amino acid ABC transporter ATP-binding protein NP_827340.1 7410741 D 227882 CDS NP_827341.1 29832707 1216585 7411829..7412623 1 NC_003155.4 branched-chain amino acid ABC transporter ATP-binding protein 7412623 1216585 SAV_6165 Streptomyces avermitilis MA-4680 branched-chain amino acid ABC transporter ATP-binding protein NP_827341.1 7411829 D 227882 CDS NP_827342.1 29832708 1216586 7412620..7413510 1 NC_003155.4 branched-chain amino acid ABC transporter permease 7413510 1216586 SAV_6166 Streptomyces avermitilis MA-4680 branched-chain amino acid ABC transporter permease NP_827342.1 7412620 D 227882 CDS NP_827343.1 29832709 1216587 7413503..7414684 1 NC_003155.4 branched-chain amino acid ABC transporter permease 7414684 1216587 SAV_6167 Streptomyces avermitilis MA-4680 branched-chain amino acid ABC transporter permease NP_827343.1 7413503 D 227882 CDS NP_827344.1 29832710 1216588 7414681..7415943 1 NC_003155.4 PF01094: Receptor family ligand binding region; lipoprotein 7415943 1216588 SAV_6168 Streptomyces avermitilis MA-4680 lipoprotein NP_827344.1 7414681 D 227882 CDS NP_827345.1 29832711 1216589 complement(7416615..7417250) 1 NC_003155.4 PF07398: Protein of unknown function (DUF1503); hypothetical protein 7417250 1216589 SAV_6169 Streptomyces avermitilis MA-4680 hypothetical protein NP_827345.1 7416615 R 227882 CDS NP_827346.1 29832712 1211422 7417371..7417772 1 NC_003155.4 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers; phosphoribosyl-AMP cyclohydrolase 7417772 hisI 1211422 hisI Streptomyces avermitilis MA-4680 phosphoribosyl-AMP cyclohydrolase NP_827346.1 7417371 D 227882 CDS NP_827347.1 29832713 1211423 7417784..7419265 1 NC_003155.4 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 7419265 trpE 1211423 trpE Streptomyces avermitilis MA-4680 anthranilate synthase component I NP_827347.1 7417784 D 227882 CDS NP_827348.1 29832714 1216590 7419325..7419969 1 NC_003155.4 hypothetical protein 7419969 1216590 SAV_6172 Streptomyces avermitilis MA-4680 hypothetical protein NP_827348.1 7419325 D 227882 CDS NP_827349.1 29832715 1216591 7420103..7420342 1 NC_003155.4 hypothetical protein 7420342 1216591 SAV_6173 Streptomyces avermitilis MA-4680 hypothetical protein NP_827349.1 7420103 D 227882 CDS NP_827350.1 29832716 1216592 7420443..7420931 1 NC_003155.4 hypothetical protein 7420931 1216592 SAV_6174 Streptomyces avermitilis MA-4680 hypothetical protein NP_827350.1 7420443 D 227882 CDS NP_827351.1 29832717 1211424 7421097..7421906 1 NC_003155.4 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol-phosphate synthase 7421906 trpC 1211424 trpC Streptomyces avermitilis MA-4680 indole-3-glycerol-phosphate synthase NP_827351.1 7421097 D 227882 CDS NP_827352.1 29832718 1216593 7421914..7422222 1 NC_003155.4 hypothetical protein 7422222 1216593 SAV_6176 Streptomyces avermitilis MA-4680 hypothetical protein NP_827352.1 7421914 D 227882 CDS NP_827353.1 29832719 1211425 7422537..7423823 1 NC_003155.4 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 7423823 trpB 1211425 trpB Streptomyces avermitilis MA-4680 tryptophan synthase subunit beta NP_827353.1 7422537 D 227882 CDS NP_827354.1 29832720 1211426 7423820..7424653 1 NC_003155.4 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 7424653 trpA 1211426 trpA Streptomyces avermitilis MA-4680 tryptophan synthase subunit alpha NP_827354.1 7423820 D 227882 CDS NP_827355.1 29832721 1216594 7424712..7425542 1 NC_003155.4 PF01323: DSBA-like thioredoxin domain; integral membrane protein 7425542 1216594 SAV_6179 Streptomyces avermitilis MA-4680 integral membrane protein NP_827355.1 7424712 D 227882 CDS NP_827356.1 29832722 1211427 7425659..7426681 1 NC_003155.4 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 7426681 lgt 1211427 lgt Streptomyces avermitilis MA-4680 prolipoprotein diacylglyceryl transferase NP_827356.1 7425659 D 227882 CDS NP_827357.1 29832723 1211428 complement(7426734..7427591) 1 NC_003155.4 citrate lyase beta chain 7427591 citE1 1211428 citE1 Streptomyces avermitilis MA-4680 citrate lyase beta chain NP_827357.1 7426734 R 227882 CDS NP_827358.1 29832724 1216595 complement(7427588..7428796) 1 NC_003155.4 acyl-CoA transferase/carnitine dehydratase 7428796 1216595 SAV_6182 Streptomyces avermitilis MA-4680 acyl-CoA transferase/carnitine dehydratase NP_827358.1 7427588 R 227882 CDS NP_827359.1 29832725 1216596 complement(7428930..7430303) 1 NC_003155.4 PF03747: ADP-ribosylglycohydrolase; hypothetical protein 7430303 1216596 SAV_6183 Streptomyces avermitilis MA-4680 hypothetical protein NP_827359.1 7428930 R 227882 CDS NP_827360.1 29832726 1216597 complement(7430300..7431496) 1 NC_003155.4 PF03747: ADP-ribosylglycohydrolase; hypothetical protein 7431496 1216597 SAV_6184 Streptomyces avermitilis MA-4680 hypothetical protein NP_827360.1 7430300 R 227882 CDS NP_827361.1 29832727 1216598 complement(7431504..7432013) 1 NC_003155.4 frameshift; hypothetical protein 7432013 1216598 SAV_6185 Streptomyces avermitilis MA-4680 hypothetical protein NP_827361.1 7431504 R 227882 CDS NP_827362.1 29832728 1216599 complement(7431829..7432746) 1 NC_003155.4 frameshift; hypothetical protein 7432746 1216599 SAV_6186 Streptomyces avermitilis MA-4680 hypothetical protein NP_827362.1 7431829 R 227882 CDS NP_827363.1 29832729 1216600 complement(7432743..7434029) 1 NC_003155.4 PF03747: ADP-ribosylglycohydrolase; hypothetical protein 7434029 1216600 SAV_6187 Streptomyces avermitilis MA-4680 hypothetical protein NP_827363.1 7432743 R 227882 CDS NP_827364.1 29832730 1216601 7434278..7435009 1 NC_003155.4 PF01988: Integral membrane protein DUF125; hypothetical protein 7435009 1216601 SAV_6188 Streptomyces avermitilis MA-4680 hypothetical protein NP_827364.1 7434278 D 227882 CDS NP_827365.1 29832731 1211429 7435466..7440016 1 NC_003155.4 glutamate synthase(NADPH) large subunit 7440016 gltB 1211429 gltB Streptomyces avermitilis MA-4680 glutamate synthase(NADPH) large subunit NP_827365.1 7435466 D 227882 CDS NP_827366.1 29832732 1211430 7440009..7441469 1 NC_003155.4 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 7441469 gltD 1211430 gltD Streptomyces avermitilis MA-4680 glutamate synthase subunit beta NP_827366.1 7440009 D 227882 CDS NP_827367.1 29832733 1216602 complement(7441635..7442489) 1 NC_003155.4 PF01374: Glycosyl hydrolase family 46; chitosanase 7442489 csn2 1216602 csn2 Streptomyces avermitilis MA-4680 chitosanase NP_827367.1 7441635 R 227882 CDS NP_827368.1 29832734 1216603 complement(7442528..7443493) 1 NC_003155.4 PF01694: Rhomboid family; hypothetical protein 7443493 1216603 SAV_6192 Streptomyces avermitilis MA-4680 hypothetical protein NP_827368.1 7442528 R 227882 CDS NP_827369.1 29832735 1216604 7443640..7444359 1 NC_003155.4 toxic cation resistance protein 7444359 1216604 SAV_6193 Streptomyces avermitilis MA-4680 toxic cation resistance protein NP_827369.1 7443640 D 227882 CDS NP_827370.1 29832736 1216605 7444320..7444934 1 NC_003155.4 PF05962: Bacterial protein of unknown function (DUF886); hypothetical protein 7444934 1216605 SAV_6194 Streptomyces avermitilis MA-4680 hypothetical protein NP_827370.1 7444320 D 227882 CDS NP_827371.1 29832737 1211431 complement(7444912..7445871) 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 7445871 fadE26 1211431 fadE26 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_827371.1 7444912 R 227882 CDS NP_827372.1 29832738 1211432 complement(7445871..7447010) 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 7447010 fadE20 1211432 fadE20 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_827372.1 7445871 R 227882 CDS NP_827373.1 29832739 1216606 7447071..7447862 1 NC_003155.4 PF00106: short chain dehydrogenase; short chain dehydrogenase 7447862 1216606 SAV_6197 Streptomyces avermitilis MA-4680 short chain dehydrogenase NP_827373.1 7447071 D 227882 CDS NP_827374.1 29832740 1216607 7447916..7448530 1 NC_003155.4 TetR family transcriptional regulator 7448530 1216607 SAV_6198 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_827374.1 7447916 D 227882 CDS NP_827375.1 29832741 1211433 7448557..7449714 1 NC_003155.4 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; acetyl-CoA acetyltransferase 7449714 fadA3 1211433 fadA3 Streptomyces avermitilis MA-4680 acetyl-CoA acetyltransferase NP_827375.1 7448557 D 227882 CDS NP_827376.1 29832742 1211434 complement(7449753..7450811) 1 NC_003155.4 NADH-dependent, FAD-containing enoyl-ACP reductase, PF03060: 2-nitropropane dioxygenase; enoyl-ACP reductase II 7450811 fabK 1211434 fabK Streptomyces avermitilis MA-4680 enoyl-ACP reductase II NP_827376.1 7449753 R 227882 CDS NP_827377.1 29832743 1216608 complement(7450811..7451551) 1 NC_003155.4 coenzyme A transferase, subunit B 7451551 cotB 1216608 cotB Streptomyces avermitilis MA-4680 coenzyme A transferase, subunit B NP_827377.1 7450811 R 227882 CDS NP_827378.1 29832744 1216609 complement(7451548..7452396) 1 NC_003155.4 coenzyme A transferase, subunit A 7452396 cotA 1216609 cotA Streptomyces avermitilis MA-4680 coenzyme A transferase, subunit A NP_827378.1 7451548 R 227882 CDS NP_827379.1 29832745 1211435 complement(7452393..7453151) 1 NC_003155.4 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 7453151 echA13 1211435 echA13 Streptomyces avermitilis MA-4680 enoyl-CoA hydratase NP_827379.1 7452393 R 227882 CDS NP_827380.1 29832746 1216610 7453206..7454036 1 NC_003155.4 PF00106: short chain dehydrogenase; short chain dehydrogenase 7454036 1216610 SAV_6204 Streptomyces avermitilis MA-4680 short chain dehydrogenase NP_827380.1 7453206 D 227882 CDS NP_827381.1 29832747 1216611 7453994..7454941 1 NC_003155.4 PF00106: short chain dehydrogenase; short chain dehydrogenase 7454941 1216611 SAV_6205 Streptomyces avermitilis MA-4680 short chain dehydrogenase NP_827381.1 7453994 D 227882 CDS NP_827382.1 29832748 1216612 complement(7455394..7456320) 1 NC_003155.4 PF00023: Ankyrin repeat; hypothetical protein 7456320 1216612 SAV_6206 Streptomyces avermitilis MA-4680 hypothetical protein NP_827382.1 7455394 R 227882 CDS NP_827383.1 29832749 1216613 complement(7456432..7457328) 1 NC_003155.4 hypothetical protein 7457328 1216613 SAV_6207 Streptomyces avermitilis MA-4680 hypothetical protein NP_827383.1 7456432 R 227882 CDS NP_827384.1 29832750 1216614 7457485..7458360 1 NC_003155.4 trypsinogen precursor 7458360 1216614 SAV_6208 Streptomyces avermitilis MA-4680 trypsinogen precursor NP_827384.1 7457485 D 227882 CDS NP_827385.1 29832751 1216615 7458572..7459027 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 7459027 1216615 SAV_6209 Streptomyces avermitilis MA-4680 acetyltransferase NP_827385.1 7458572 D 227882 CDS NP_827386.1 29832752 1216616 7459188..7459577 1 NC_003155.4 catalyzes the interconversion of chorismate to prephenate; chorismate mutase 7459577 aroH2 1216616 aroH2 Streptomyces avermitilis MA-4680 chorismate mutase NP_827386.1 7459188 D 227882 CDS NP_827387.1 29832753 1216617 7459706..7460263 1 NC_003155.4 two-component system response regulator 7460263 1216617 SAV_6211 Streptomyces avermitilis MA-4680 two-component system response regulator NP_827387.1 7459706 D 227882 CDS NP_827388.1 29832754 1216618 7460355..7462895 1 NC_003155.4 PF01433: Peptidase family M1; aminopeptidase 7462895 1216618 SAV_6212 Streptomyces avermitilis MA-4680 aminopeptidase NP_827388.1 7460355 D 227882 CDS NP_827389.1 29832755 1216619 7463143..7464585 1 NC_003155.4 amino acid decarboxylase 7464585 1216619 SAV_6213 Streptomyces avermitilis MA-4680 amino acid decarboxylase NP_827389.1 7463143 D 227882 CDS NP_827390.1 29832756 1216620 7464582..7466000 1 NC_003155.4 PF00070: Pyridine nucleotide-disulphide oxidoreductase; monooxygenase 7466000 1216620 SAV_6214 Streptomyces avermitilis MA-4680 monooxygenase NP_827390.1 7464582 D 227882 CDS NP_827391.1 29832757 1216621 complement(7466097..7467917) 1 NC_003155.4 2',3'-cyclic-nucleotide 2'-phosphodiesterase 7467917 cpdB 1216621 cpdB Streptomyces avermitilis MA-4680 2',3'-cyclic-nucleotide 2'-phosphodiesterase NP_827391.1 7466097 R 227882 CDS NP_827392.1 29832758 1216622 7468007..7468768 1 NC_003155.4 PF04402: Protein of unknown function (DUF541); hypothetical protein 7468768 1216622 SAV_6216 Streptomyces avermitilis MA-4680 hypothetical protein NP_827392.1 7468007 D 227882 CDS NP_827393.1 29832759 1211436 7468937..7470373 1 NC_003155.4 pyruvate kinase 7470373 pykA2 1211436 pykA2 Streptomyces avermitilis MA-4680 pyruvate kinase NP_827393.1 7468937 D 227882 CDS NP_827394.1 29832760 1216623 complement(7470385..7471197) 1 NC_003155.4 hypothetical protein 7471197 1216623 SAV_6218 Streptomyces avermitilis MA-4680 hypothetical protein NP_827394.1 7470385 R 227882 CDS NP_827395.1 29832761 1216624 7471444..7472100 1 NC_003155.4 two-component system response regulator 7472100 1216624 SAV_6219 Streptomyces avermitilis MA-4680 two-component system response regulator NP_827395.1 7471444 D 227882 CDS NP_827396.1 29832762 1216625 complement(7472204..7472920) 1 NC_003155.4 branched-chain amino acid ABC transporter ATP-binding protein 7472920 1216625 SAV_6220 Streptomyces avermitilis MA-4680 branched-chain amino acid ABC transporter ATP-binding protein NP_827396.1 7472204 R 227882 CDS NP_827397.1 29832763 1216626 complement(7472917..7473861) 1 NC_003155.4 branched-chain amino acid ABC transporter ATP-binding protein 7473861 1216626 SAV_6221 Streptomyces avermitilis MA-4680 branched-chain amino acid ABC transporter ATP-binding protein NP_827397.1 7472917 R 227882 CDS NP_827398.1 29832764 1216627 complement(7473858..7475633) 1 NC_003155.4 branched-chain amino acid ABC transporter permease 7475633 1216627 SAV_6222 Streptomyces avermitilis MA-4680 branched-chain amino acid ABC transporter permease NP_827398.1 7473858 R 227882 CDS NP_827399.1 29832765 1216628 complement(7475639..7476571) 1 NC_003155.4 branched-chain amino acid ABC transporter permease 7476571 1216628 SAV_6223 Streptomyces avermitilis MA-4680 branched-chain amino acid ABC transporter permease NP_827399.1 7475639 R 227882 CDS NP_827400.1 29832766 1216629 complement(7476683..7477912) 1 NC_003155.4 ABC transporter periplasmic component; periplasmic branched-chain amino acid-binding protein 7477912 1216629 SAV_6224 Streptomyces avermitilis MA-4680 periplasmic branched-chain amino acid-binding protein NP_827400.1 7476683 R 227882 CDS NP_827401.1 29832767 1216630 complement(7478832..7479293) 1 NC_003155.4 PF03061: Thioesterase superfamily; hypothetical protein 7479293 1216630 SAV_6225 Streptomyces avermitilis MA-4680 hypothetical protein NP_827401.1 7478832 R 227882 CDS NP_827402.1 29832768 1211438 complement(7479360..7481642) 1 NC_003155.4 formate dehydrogenase 7481642 fdhF 1211438 fdhF Streptomyces avermitilis MA-4680 formate dehydrogenase NP_827402.1 7479360 R 227882 CDS NP_827403.1 29832769 1211439 7481798..7484521 1 NC_003155.4 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 7484521 polA1 1211439 polA1 Streptomyces avermitilis MA-4680 DNA polymerase I NP_827403.1 7481798 D 227882 CDS NP_827404.1 29832770 1216631 complement(7484789..7486030) 1 NC_003155.4 PF04307: Predicted membrane-bound metal-dependent hydrolase (DUF457); hypothetical protein 7486030 1216631 SAV_6228 Streptomyces avermitilis MA-4680 hypothetical protein NP_827404.1 7484789 R 227882 CDS NP_827405.1 29832771 1216632 7486082..7487791 1 NC_003155.4 PF01464: Transglycosylase SLT domain; protein 7487791 1216632 SAV_6229 Streptomyces avermitilis MA-4680 protein NP_827405.1 7486082 D 227882 CDS NP_827406.1 29832772 1216633 7488093..7489085 1 NC_003155.4 hypothetical protein 7489085 1216633 SAV_6230 Streptomyces avermitilis MA-4680 hypothetical protein NP_827406.1 7488093 D 227882 CDS NP_827407.1 29832773 1216634 complement(7489075..7491708) 1 NC_003155.4 PF04408: Helicase associated domain (HA2); ATP-dependent RNA helicase 7491708 1216634 SAV_6231 Streptomyces avermitilis MA-4680 ATP-dependent RNA helicase NP_827407.1 7489075 R 227882 CDS NP_827408.1 29832774 1216635 complement(7491713..7492582) 1 NC_003155.4 SAM-dependent methyltransferase 7492582 1216635 SAV_6232 Streptomyces avermitilis MA-4680 SAM-dependent methyltransferase NP_827408.1 7491713 R 227882 CDS NP_827409.1 29832775 1211440 7492899..7494404 1 NC_003155.4 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 7494404 rpsA 1211440 rpsA Streptomyces avermitilis MA-4680 30S ribosomal protein S1 NP_827409.1 7492899 D 227882 CDS NP_827410.1 29832776 1216636 7494729..7495667 1 NC_003155.4 PF05601: Protein of unknown function (DUF774); hypothetical protein 7495667 1216636 SAV_6234 Streptomyces avermitilis MA-4680 hypothetical protein NP_827410.1 7494729 D 227882 CDS NP_827411.1 29832777 1211441 7495699..7496340 1 NC_003155.4 dephospho-CoA kinase 7496340 coaE 1211441 coaE Streptomyces avermitilis MA-4680 dephospho-CoA kinase NP_827411.1 7495699 D 227882 CDS NP_827412.1 29832778 1216637 7496391..7496771 1 NC_003155.4 PF00515: TPR Domain; hypothetical protein 7496771 1216637 SAV_6236 Streptomyces avermitilis MA-4680 hypothetical protein NP_827412.1 7496391 D 227882 CDS NP_827413.1 29832779 1216638 complement(7496817..7497092) 1 NC_003155.4 hypothetical protein 7497092 1216638 SAV_6237 Streptomyces avermitilis MA-4680 hypothetical protein NP_827413.1 7496817 R 227882 CDS NP_827414.1 29832780 1216639 7497119..7498156 1 NC_003155.4 hypothetical protein 7498156 1216639 SAV_6238 Streptomyces avermitilis MA-4680 hypothetical protein NP_827414.1 7497119 D 227882 CDS NP_827415.1 29832781 1216640 7498232..7498915 1 NC_003155.4 hypothetical protein 7498915 1216640 SAV_6239 Streptomyces avermitilis MA-4680 hypothetical protein NP_827415.1 7498232 D 227882 CDS NP_827416.1 29832782 1216641 7498976..7499518 1 NC_003155.4 PF07681: DoxX; hypothetical protein 7499518 1216641 SAV_6240 Streptomyces avermitilis MA-4680 hypothetical protein NP_827416.1 7498976 D 227882 CDS NP_827417.1 29832783 1216642 complement(7499778..7500416) 1 NC_003155.4 PF01479: S4 domain; hypothetical protein 7500416 1216642 SAV_6241 Streptomyces avermitilis MA-4680 hypothetical protein NP_827417.1 7499778 R 227882 CDS NP_827418.1 29832784 1216643 7500537..7501331 1 NC_003155.4 PF03167: Uracil DNA glycosylase superfamily; hypothetical protein 7501331 1216643 SAV_6242 Streptomyces avermitilis MA-4680 hypothetical protein NP_827418.1 7500537 D 227882 CDS NP_827419.1 29832785 1216644 complement(7501328..7501735) 1 NC_003155.4 hypothetical protein 7501735 1216644 SAV_6243 Streptomyces avermitilis MA-4680 hypothetical protein NP_827419.1 7501328 R 227882 CDS NP_827420.1 29832786 1216645 complement(7501884..7502471) 1 NC_003155.4 PF01042: Endoribonuclease L-PSP; hypothetical protein 7502471 1216645 SAV_6244 Streptomyces avermitilis MA-4680 hypothetical protein NP_827420.1 7501884 R 227882 CDS NP_827421.1 29832787 1216646 7502573..7502950 1 NC_003155.4 hypothetical protein 7502950 1216646 SAV_6245 Streptomyces avermitilis MA-4680 hypothetical protein NP_827421.1 7502573 D 227882 CDS NP_827422.1 29832788 1216647 7503439..7504629 1 NC_003155.4 hypothetical protein 7504629 1216647 SAV_6246 Streptomyces avermitilis MA-4680 hypothetical protein NP_827422.1 7503439 D 227882 CDS NP_827423.1 29832789 1216648 7504662..7505135 1 NC_003155.4 hypothetical protein 7505135 1216648 SAV_6247 Streptomyces avermitilis MA-4680 hypothetical protein NP_827423.1 7504662 D 227882 CDS NP_827424.1 29832790 1216649 7506001..7507863 1 NC_003155.4 PF05976: Bacterial membrane protein of unknown function (DUF893); integral membrane protein 7507863 1216649 SAV_6248 Streptomyces avermitilis MA-4680 integral membrane protein NP_827424.1 7506001 D 227882 CDS NP_827425.1 29832791 1211442 7508111..7509277 1 NC_003155.4 CYP107X1; cytochrome P450 7509277 cyp23 1211442 cyp23 Streptomyces avermitilis MA-4680 cytochrome P450 NP_827425.1 7508111 D 227882 CDS NP_827426.1 29832792 1216650 7509535..7509708 1 NC_003155.4 hypothetical protein 7509708 1216650 SAV_6250 Streptomyces avermitilis MA-4680 hypothetical protein NP_827426.1 7509535 D 227882 CDS NP_827427.1 29832793 1216651 complement(7509771..7510226) 1 NC_003155.4 hypothetical protein 7510226 1216651 SAV_6251 Streptomyces avermitilis MA-4680 hypothetical protein NP_827427.1 7509771 R 227882 CDS NP_827428.1 29832794 1216652 complement(7510217..7510921) 1 NC_003155.4 regulatory protein 7510921 1216652 SAV_6252 Streptomyces avermitilis MA-4680 regulatory protein NP_827428.1 7510217 R 227882 CDS NP_827429.1 29832795 1216653 7511100..7511960 1 NC_003155.4 DNA-binding protein 7511960 1216653 SAV_6253 Streptomyces avermitilis MA-4680 DNA-binding protein NP_827429.1 7511100 D 227882 CDS NP_827430.1 29832796 1211443 7511961..7512254 1 NC_003155.4 regulatory protein; AbaA-like protein 7512254 abaA2 1211443 abaA2 Streptomyces avermitilis MA-4680 AbaA-like protein NP_827430.1 7511961 D 227882 CDS NP_827431.1 29832797 1216654 7512494..7513309 1 NC_003155.4 PF04672: Protein of unknown function (DUF574); hypothetical protein 7513309 1216654 SAV_6255 Streptomyces avermitilis MA-4680 hypothetical protein NP_827431.1 7512494 D 227882 CDS NP_827432.1 29832798 1216655 complement(7513568..7514980) 1 NC_003155.4 GntR family transcriptional regulator 7514980 1216655 SAV_6256 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_827432.1 7513568 R 227882 CDS NP_827433.1 29832799 1216656 7515022..7515537 1 NC_003155.4 PF02627: Carboxymuconolactone decarboxylase family; hypothetical protein 7515537 1216656 SAV_6257 Streptomyces avermitilis MA-4680 hypothetical protein NP_827433.1 7515022 D 227882 CDS NP_827434.1 29832800 1211444 complement(7515610..7517100) 1 NC_003155.4 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain; putative oxidoreductase 7517100 gltD2 1211444 gltD2 Streptomyces avermitilis MA-4680 putative oxidoreductase NP_827434.1 7515610 R 227882 CDS NP_827435.1 29832801 1216657 complement(7517288..7517767) 1 NC_003155.4 integral membrane protein 7517767 1216657 SAV_6259 Streptomyces avermitilis MA-4680 integral membrane protein NP_827435.1 7517288 R 227882 CDS NP_827436.1 29832802 1216658 complement(7518066..7518884) 1 NC_003155.4 PF00643: B-box zinc finger; hypothetical protein 7518884 1216658 SAV_6260 Streptomyces avermitilis MA-4680 hypothetical protein NP_827436.1 7518066 R 227882 CDS NP_827437.1 29832803 1216659 7518944..7519588 1 NC_003155.4 hypothetical protein 7519588 1216659 SAV_6261 Streptomyces avermitilis MA-4680 hypothetical protein NP_827437.1 7518944 D 227882 CDS NP_827438.1 29832804 1216660 7519576..7520064 1 NC_003155.4 PF01243: Pyridoxamine 5'-phosphate oxidase; hypothetical protein 7520064 1216660 SAV_6262 Streptomyces avermitilis MA-4680 hypothetical protein NP_827438.1 7519576 D 227882 CDS NP_827439.1 29832805 1216661 7520157..7520630 1 NC_003155.4 PF00571: CBS domain; hypothetical protein 7520630 1216661 SAV_6263 Streptomyces avermitilis MA-4680 hypothetical protein NP_827439.1 7520157 D 227882 CDS NP_827440.1 29832806 1216662 complement(7520675..7521739) 1 NC_003155.4 metal-transport protein 7521739 corA1 1216662 corA1 Streptomyces avermitilis MA-4680 metal-transport protein NP_827440.1 7520675 R 227882 CDS NP_827441.1 29832807 1216663 7522014..7522808 1 NC_003155.4 methyltransferase 7522808 1216663 SAV_6265 Streptomyces avermitilis MA-4680 methyltransferase NP_827441.1 7522014 D 227882 CDS NP_827442.1 29832808 1216664 complement(7522851..7523795) 1 NC_003155.4 sugar kinase 7523795 1216664 SAV_6266 Streptomyces avermitilis MA-4680 sugar kinase NP_827442.1 7522851 R 227882 CDS NP_827443.1 29832809 1216665 complement(7523792..7524697) 1 NC_003155.4 uncharacterized enzyme involved in pigment biosynthesis, PF04227: Indigoidine synthase A like protein; pigment biosynthetic protein 7524697 indA 1216665 indA Streptomyces avermitilis MA-4680 pigment biosynthetic protein NP_827443.1 7523792 R 227882 CDS NP_827444.1 29832810 1216666 7524759..7525223 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; dioxygenase 7525223 1216666 SAV_6268 Streptomyces avermitilis MA-4680 dioxygenase NP_827444.1 7524759 D 227882 CDS NP_827445.1 29832811 1216667 7525326..7525688 1 NC_003155.4 PF05899: Protein of unknown function (DUF861); hypothetical protein 7525688 1216667 SAV_6269 Streptomyces avermitilis MA-4680 hypothetical protein NP_827445.1 7525326 D 227882 CDS NP_827446.1 29832812 1211445 complement(7525710..7526264) 1 NC_003155.4 methylated-DNA--protein-cysteine S-methyltransferase 7526264 ogt3 1211445 ogt3 Streptomyces avermitilis MA-4680 methylated-DNA--protein-cysteine S-methyltransferase NP_827446.1 7525710 R 227882 CDS NP_827447.1 29832813 1216668 complement(7526371..7527243) 1 NC_003155.4 glycerophosphoryl diester phosphodiesterase 7527243 glpQ6 1216668 glpQ6 Streptomyces avermitilis MA-4680 glycerophosphoryl diester phosphodiesterase NP_827447.1 7526371 R 227882 CDS NP_827448.1 29832814 1216669 7527524..7528390 1 NC_003155.4 PF03707: Bacterial signalling protein N terminal repeat; integral membrane protein 7528390 1216669 SAV_6272 Streptomyces avermitilis MA-4680 integral membrane protein NP_827448.1 7527524 D 227882 CDS NP_827449.1 29832815 1211446 7528431..7530572 1 NC_003155.4 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 7530572 uvrB 1211446 uvrB Streptomyces avermitilis MA-4680 excinuclease ABC subunit B NP_827449.1 7528431 D 227882 CDS NP_827450.1 29832816 1216670 7530828..7531406 1 NC_003155.4 PF02342: Bacterial stress protein; export associated protein 7531406 1216670 SAV_6274 Streptomyces avermitilis MA-4680 export associated protein NP_827450.1 7530828 D 227882 CDS NP_827451.1 29832817 1216671 7531487..7533574 1 NC_003155.4 PF02342: Bacterial stress protein; export associated protein 7533574 1216671 SAV_6275 Streptomyces avermitilis MA-4680 export associated protein NP_827451.1 7531487 D 227882 CDS NP_827452.1 29832818 1216672 7533900..7534889 1 NC_003155.4 PF03741: Integral membrane protein TerC family; integral membrane export protein 7534889 1216672 SAV_6276 Streptomyces avermitilis MA-4680 integral membrane export protein NP_827452.1 7533900 D 227882 CDS NP_827453.1 29832819 1216673 7535097..7536197 1 NC_003155.4 PF01699: Sodium/calcium exchanger protein; ionic transporter integral membrane protein 7536197 chaA 1216673 chaA Streptomyces avermitilis MA-4680 ionic transporter integral membrane protein NP_827453.1 7535097 D 227882 CDS NP_827454.1 29832820 1216674 complement(7536257..7537561) 1 NC_003155.4 PF00083: Sugar (and other) transporter; transmembrane efflux protein 7537561 1216674 SAV_6278 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_827454.1 7536257 R 227882 CDS NP_827455.1 29832821 1216675 complement(7537643..7538758) 1 NC_003155.4 PF02016: LD-carboxypeptidase; hypothetical protein 7538758 1216675 SAV_6279 Streptomyces avermitilis MA-4680 hypothetical protein NP_827455.1 7537643 R 227882 CDS NP_827456.1 29832822 1211447 7538791..7539270 1 NC_003155.4 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis; 3-dehydroquinate dehydratase 7539270 aroD 1211447 aroD Streptomyces avermitilis MA-4680 3-dehydroquinate dehydratase NP_827456.1 7538791 D 227882 CDS NP_827457.1 29832823 1216676 complement(7539316..7540092) 1 NC_003155.4 glutamine ABC transporter ATP-binding protein 7540092 1216676 SAV_6281 Streptomyces avermitilis MA-4680 glutamine ABC transporter ATP-binding protein NP_827457.1 7539316 R 227882 CDS NP_827458.1 29832824 1216677 complement(7540089..7541042) 1 NC_003155.4 glutamine ABC transporter permease 7541042 1216677 SAV_6282 Streptomyces avermitilis MA-4680 glutamine ABC transporter permease NP_827458.1 7540089 R 227882 CDS NP_827459.1 29832825 1216678 complement(7541003..7541941) 1 NC_003155.4 amino acid ABC transporter, periplasmic amino acid-binding protein 7541941 1216678 SAV_6283 Streptomyces avermitilis MA-4680 amino acid ABC transporter, periplasmic amino acid-binding protein NP_827459.1 7541003 R 227882 CDS NP_827460.1 29832826 1216679 complement(7542238..7542894) 1 NC_003155.4 PF00753: Metallo-beta-lactamase superfamily; Zn-dependent hydrolase 7542894 1216679 SAV_6284 Streptomyces avermitilis MA-4680 Zn-dependent hydrolase NP_827460.1 7542238 R 227882 CDS NP_827461.1 29832827 1216680 complement(7542905..7543690) 1 NC_003155.4 in Corynebacterium glutamicum this enzyme catalyzes the conversion of maleylpyruvate into fumarylpyruvate in a glutathione-independent gentisate pathway; dependent on mycothiol; mycothiol-dependent maleylpyruvate isomerase 7543690 1216680 SAV_6285 Streptomyces avermitilis MA-4680 mycothiol-dependent maleylpyruvate isomerase NP_827461.1 7542905 R 227882 CDS NP_827462.1 29832828 1211448 7543816..7546845 1 NC_003155.4 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 7546845 uvrA 1211448 uvrA Streptomyces avermitilis MA-4680 excinuclease ABC subunit A NP_827462.1 7543816 D 227882 CDS NP_827463.1 29832829 1211449 complement(7547242..7548153) 1 NC_003155.4 fructokinase 7548153 scrK2 1211449 scrK2 Streptomyces avermitilis MA-4680 fructokinase NP_827463.1 7547242 R 227882 CDS NP_827464.1 29832830 1216681 complement(7548150..7549199) 1 NC_003155.4 LacI family transcriptional regulator 7549199 1216681 SAV_6288 Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_827464.1 7548150 R 227882 CDS NP_827465.1 29832831 1216682 7549417..7549842 1 NC_003155.4 iron sulphur protein 7549842 1216682 SAV_6289 Streptomyces avermitilis MA-4680 iron sulphur protein NP_827465.1 7549417 D 227882 CDS NP_827466.1 29832832 1216683 complement(7549900..7550847) 1 NC_003155.4 hypothetical protein 7550847 1216683 SAV_6290 Streptomyces avermitilis MA-4680 hypothetical protein NP_827466.1 7549900 R 227882 CDS NP_827467.1 29832833 1211450 7551262..7553307 1 NC_003155.4 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 7553307 uvrC 1211450 uvrC Streptomyces avermitilis MA-4680 excinuclease ABC subunit C NP_827467.1 7551262 D 227882 CDS NP_827468.1 29832834 1216684 7553304..7554317 1 NC_003155.4 PF03668: P-loop ATPase protein family; hypothetical protein 7554317 1216684 SAV_6292 Streptomyces avermitilis MA-4680 hypothetical protein NP_827468.1 7553304 D 227882 CDS NP_827469.1 29832835 1216685 7554314..7555381 1 NC_003155.4 PF01933: Uncharacterised protein family UPF0052; hypothetical protein 7555381 1216685 SAV_6293 Streptomyces avermitilis MA-4680 hypothetical protein NP_827469.1 7554314 D 227882 CDS NP_827470.1 29832836 1216686 7555372..7556361 1 NC_003155.4 sporulation regulatory protein 7556361 whiA 1216686 whiA Streptomyces avermitilis MA-4680 sporulation regulatory protein NP_827470.1 7555372 D 227882 CDS NP_827471.1 29832837 1216687 7556529..7559483 1 NC_003155.4 PF00246: Zinc carboxypeptidase; carboxypeptidase 7559483 1216687 SAV_6295 Streptomyces avermitilis MA-4680 carboxypeptidase NP_827471.1 7556529 D 227882 CDS NP_827472.1 29832838 1211451 7559711..7560718 1 NC_003155.4 glyceraldehyde-3-phosphate dehydrogenase 7560718 gap2 1211451 gap2 Streptomyces avermitilis MA-4680 glyceraldehyde-3-phosphate dehydrogenase NP_827472.1 7559711 D 227882 CDS NP_827473.1 29832839 1211452 7560846..7562057 1 NC_003155.4 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 7562057 pgk 1211452 pgk Streptomyces avermitilis MA-4680 phosphoglycerate kinase NP_827473.1 7560846 D 227882 CDS NP_827474.1 29832840 1211453 7562063..7562839 1 NC_003155.4 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 7562839 tpiA 1211453 tpiA Streptomyces avermitilis MA-4680 triosephosphate isomerase NP_827474.1 7562063 D 227882 CDS NP_827475.1 29832841 1211454 7562869..7563207 1 NC_003155.4 PF03840: Preprotein translocase SecG subunit; preprotein translocase subunit SecG 7563207 secG 1211454 secG Streptomyces avermitilis MA-4680 preprotein translocase subunit SecG NP_827475.1 7562869 D 227882 CDS NP_827476.1 29832842 1216688 7563427..7563762 1 NC_003155.4 electron transport protein 7563762 1216688 SAV_6300 Streptomyces avermitilis MA-4680 electron transport protein NP_827476.1 7563427 D 227882 CDS NP_827477.1 29832843 1216689 7563791..7565161 1 NC_003155.4 PF07690: Major Facilitator Superfamily; antibiotic transport protein 7565161 1216689 SAV_6301 Streptomyces avermitilis MA-4680 antibiotic transport protein NP_827477.1 7563791 D 227882 CDS NP_827478.1 29832844 1211455 7565234..7566886 1 NC_003155.4 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 7566886 pgi 1211455 pgi Streptomyces avermitilis MA-4680 glucose-6-phosphate isomerase NP_827478.1 7565234 D 227882 CDS NP_827479.1 29832845 1216690 complement(7567065..7569371) 1 NC_003155.4 peptide ABC transporter permease 7569371 1216690 SAV_6303 Streptomyces avermitilis MA-4680 peptide ABC transporter permease NP_827479.1 7567065 R 227882 CDS NP_827480.1 29832846 1216691 complement(7569642..7570388) 1 NC_003155.4 ABC transporter ATP-binding protein 7570388 1216691 SAV_6304 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_827480.1 7569642 R 227882 CDS NP_827481.1 29832847 1216692 complement(7570385..7570900) 1 NC_003155.4 PadR-family transcriptional regulator 7570900 1216692 SAV_6305 Streptomyces avermitilis MA-4680 PadR-family transcriptional regulator NP_827481.1 7570385 R 227882 CDS NP_827482.1 29832848 1216693 7571001..7572329 1 NC_003155.4 ABC transporter substrate-binding protein 7572329 1216693 SAV_6306 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_827482.1 7571001 D 227882 CDS NP_827483.1 29832849 1211456 7572458..7574164 1 NC_003155.4 trehalose-6-phosphate hydrolase 7574164 treA 1211456 treA Streptomyces avermitilis MA-4680 trehalose-6-phosphate hydrolase NP_827483.1 7572458 D 227882 CDS NP_827484.1 29832850 1216694 7574227..7575549 1 NC_003155.4 ABC transporter substrate-binding protein 7575549 1216694 SAV_6308 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_827484.1 7574227 D 227882 CDS NP_827485.1 29832851 1216695 7575555..7576913 1 NC_003155.4 ABC transporter permease 7576913 1216695 SAV_6309 Streptomyces avermitilis MA-4680 ABC transporter permease NP_827485.1 7575555 D 227882 CDS NP_827486.1 29832852 1216696 7576910..7577749 1 NC_003155.4 ABC transporter permease 7577749 1216696 SAV_6310 Streptomyces avermitilis MA-4680 ABC transporter permease NP_827486.1 7576910 D 227882 CDS NP_827487.1 29832853 1211457 complement(7577825..7578607) 1 NC_003155.4 catalyzes the formation of 6-phospho-D-gluconate from 6-phospho-D-glucono-1,5-lactone; 6-phosphogluconolactonase 7578607 pgl 1211457 pgl Streptomyces avermitilis MA-4680 6-phosphogluconolactonase NP_827487.1 7577825 R 227882 CDS NP_827488.1 29832854 1216697 complement(7578604..7579725) 1 NC_003155.4 oxppcycle protein 7579725 opcA2 1216697 opcA2 Streptomyces avermitilis MA-4680 oxppcycle protein NP_827488.1 7578604 R 227882 CDS NP_827489.1 29832855 1211458 complement(7579722..7581245) 1 NC_003155.4 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 7581245 zwf2 1211458 zwf2 Streptomyces avermitilis MA-4680 glucose-6-phosphate 1-dehydrogenase NP_827489.1 7579722 R 227882 CDS NP_827490.1 29832856 1211459 complement(7581250..7582368) 1 NC_003155.4 catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate; transaldolase 7582368 tal2 1211459 tal2 Streptomyces avermitilis MA-4680 transaldolase NP_827490.1 7581250 R 227882 CDS NP_827491.1 29832857 1211460 complement(7582403..7584490) 1 NC_003155.4 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 7584490 tkt2 1211460 tkt2 Streptomyces avermitilis MA-4680 transketolase NP_827491.1 7582403 R 227882 CDS NP_827492.1 29832858 1211461 7584999..7585856 1 NC_003155.4 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 7585856 ctaB 1211461 ctaB Streptomyces avermitilis MA-4680 protoheme IX farnesyltransferase NP_827492.1 7584999 D 227882 CDS NP_827493.1 29832859 1216698 7585955..7586311 1 NC_003155.4 hypothetical protein 7586311 1216698 SAV_6317 Streptomyces avermitilis MA-4680 hypothetical protein NP_827493.1 7585955 D 227882 CDS NP_827494.1 29832860 1216699 7586484..7587590 1 NC_003155.4 PF04909: Amidohydrolase; hypothetical protein 7587590 1216699 SAV_6318 Streptomyces avermitilis MA-4680 hypothetical protein NP_827494.1 7586484 D 227882 CDS NP_827495.1 29832861 1216700 7587626..7588396 1 NC_003155.4 PF01909: Nucleotidyltransferase domain; hypothetical protein 7588396 1216700 SAV_6319 Streptomyces avermitilis MA-4680 hypothetical protein NP_827495.1 7587626 D 227882 CDS NP_827496.1 29832862 1216701 complement(7588383..7589438) 1 NC_003155.4 PF02628: Cytochrome oxidase assembly protein; cytochrome c oxidase subunit XV assembly protein 7589438 ctaA 1216701 ctaA Streptomyces avermitilis MA-4680 cytochrome c oxidase subunit XV assembly protein NP_827496.1 7588383 R 227882 CDS NP_827497.1 29832863 1216702 complement(7589458..7590228) 1 NC_003155.4 ABC transporter permease 7590228 1216702 SAV_6321 Streptomyces avermitilis MA-4680 ABC transporter permease NP_827497.1 7589458 R 227882 CDS NP_827498.1 29832864 1216703 complement(7590225..7591157) 1 NC_003155.4 ABC transporter ATP-binding protein 7591157 1216703 SAV_6322 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_827498.1 7590225 R 227882 CDS NP_827499.1 29832865 1216704 complement(7591308..7591499) 1 NC_003155.4 hypothetical protein 7591499 1216704 SAV_6323 Streptomyces avermitilis MA-4680 hypothetical protein NP_827499.1 7591308 R 227882 CDS NP_827500.1 29832866 1216705 7591661..7592410 1 NC_003155.4 DNA-binding protein 7592410 1216705 SAV_6324 Streptomyces avermitilis MA-4680 DNA-binding protein NP_827500.1 7591661 D 227882 CDS NP_827501.1 29832867 1216706 7592407..7593831 1 NC_003155.4 iron-regulated ABC-type transporter 7593831 sufB 1216706 sufB Streptomyces avermitilis MA-4680 iron-regulated ABC-type transporter NP_827501.1 7592407 D 227882 CDS NP_827502.1 29832868 1216707 7593919..7595100 1 NC_003155.4 iron-regulated ABC-type transporter 7595100 1216707 SAV_6326 Streptomyces avermitilis MA-4680 iron-regulated ABC-type transporter NP_827502.1 7593919 D 227882 CDS NP_827503.1 29832869 1216708 7595100..7595420 1 NC_003155.4 PF00355: Rieske [2Fe-2S] domain; ferredoxin subunit of phenylpropionate dioxygenase 7595420 hcaC1 1216708 hcaC1 Streptomyces avermitilis MA-4680 ferredoxin subunit of phenylpropionate dioxygenase NP_827503.1 7595100 D 227882 CDS NP_827504.1 29832870 1216709 7595428..7596210 1 NC_003155.4 ABC transporter ATP-binding protein 7596210 1216709 SAV_6328 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_827504.1 7595428 D 227882 CDS NP_827505.1 29832871 1211462 7596207..7597463 1 NC_003155.4 aminotransferase 7597463 1211462 SAV_6329 Streptomyces avermitilis MA-4680 aminotransferase NP_827505.1 7596207 D 227882 CDS NP_827506.1 29832872 1216710 7597480..7597947 1 NC_003155.4 hypothetical protein 7597947 1216710 SAV_6330 Streptomyces avermitilis MA-4680 hypothetical protein NP_827506.1 7597480 D 227882 CDS NP_827507.1 29832873 1216711 7597944..7598276 1 NC_003155.4 PF01883: Domain of unknown function DUF59; hypothetical protein 7598276 1216711 SAV_6331 Streptomyces avermitilis MA-4680 hypothetical protein NP_827507.1 7597944 D 227882 CDS NP_827508.1 29832874 1216712 complement(7598377..7599327) 1 NC_003155.4 alpha-L-arabinofuranosidase 7599327 1216712 SAV_6332 Streptomyces avermitilis MA-4680 alpha-L-arabinofuranosidase NP_827508.1 7598377 R 227882 CDS NP_827509.1 29832875 1216713 complement(7599643..7599810) 1 NC_003155.4 hypothetical protein 7599810 1216713 SAV_6333 Streptomyces avermitilis MA-4680 hypothetical protein NP_827509.1 7599643 R 227882 CDS NP_827510.2 57833864 1216714 complement(7600087..7601163) 1 NC_003155.4 integral membrane protein 7601163 1216714 SAV_6335 Streptomyces avermitilis MA-4680 integral membrane protein NP_827510.2 7600087 R 227882 CDS NP_827511.2 57833865 1216715 7601369..7601689 1 NC_003155.4 SMR-type multi-drug efflux transporter 7601689 emrE 1216715 emrE Streptomyces avermitilis MA-4680 SMR-type multi-drug efflux transporter NP_827511.2 7601369 D 227882 CDS NP_827512.1 29832878 1216716 7601712..7602248 1 NC_003155.4 TetR family transcriptional regulator 7602248 1216716 SAV_6336 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_827512.1 7601712 D 227882 CDS NP_827513.1 29832879 1211463 7602496..7603089 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 7603089 sig50 1211463 sig50 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_827513.1 7602496 D 227882 CDS NP_827514.1 29832880 1216717 7603092..7604084 1 NC_003155.4 hypothetical protein 7604084 1216717 SAV_6338 Streptomyces avermitilis MA-4680 hypothetical protein NP_827514.1 7603092 D 227882 CDS NP_827515.1 29832881 1211464 7604205..7605194 1 NC_003155.4 2,3,4,5-tetrahydropyridine-2- carboxylate N-succinyltransferase 7605194 dapD 1211464 dapD Streptomyces avermitilis MA-4680 2,3,4,5-tetrahydropyridine-2- carboxylate N-succinyltransferase NP_827515.1 7604205 D 227882 CDS NP_827516.1 29832882 1216718 complement(7606506..7607087) 1 NC_003155.4 protein 7607087 1216718 SAV_6341 Streptomyces avermitilis MA-4680 protein NP_827516.1 7606506 R 227882 CDS NP_827517.1 29832883 1211465 7607082..7607702 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 7607702 sig51 1211465 sig51 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_827517.1 7607082 D 227882 CDS NP_827518.1 29832884 1216719 7607699..7608919 1 NC_003155.4 hypothetical protein 7608919 1216719 SAV_6342 Streptomyces avermitilis MA-4680 hypothetical protein NP_827518.1 7607699 D 227882 CDS NP_827519.1 29832885 1211466 complement(7608906..7609853) 1 NC_003155.4 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 7609853 dapA5 1211466 dapA5 Streptomyces avermitilis MA-4680 dihydrodipicolinate synthase NP_827519.1 7608906 R 227882 CDS NP_827520.1 29832886 1216720 7609979..7610839 1 NC_003155.4 hypothetical protein 7610839 1216720 SAV_6344 Streptomyces avermitilis MA-4680 hypothetical protein NP_827520.1 7609979 D 227882 CDS NP_827521.1 29832887 1216721 7610905..7611315 1 NC_003155.4 PF07332: Protein of unknown function (DUF1469); integral membrane protein 7611315 1216721 SAV_6345 Streptomyces avermitilis MA-4680 integral membrane protein NP_827521.1 7610905 D 227882 CDS NP_827522.1 29832888 1216722 7611312..7612058 1 NC_003155.4 hypothetical protein 7612058 1216722 SAV_6346 Streptomyces avermitilis MA-4680 hypothetical protein NP_827522.1 7611312 D 227882 CDS NP_827523.1 29832889 1216723 complement(7612276..7614102) 1 NC_003155.4 PF03372: Endonuclease/Exonuclease/phosphatase family; large protein 7614102 1216723 SAV_6347 Streptomyces avermitilis MA-4680 large protein NP_827523.1 7612276 R 227882 CDS NP_827524.1 29832890 1216724 7614461..7615906 1 NC_003155.4 hypothetical protein 7615906 1216724 SAV_6348 Streptomyces avermitilis MA-4680 hypothetical protein NP_827524.1 7614461 D 227882 CDS NP_827525.1 29832891 1216725 7616478..7617947 1 NC_003155.4 PF05787: Bacterial protein of unknown function (DUF839); protein 7617947 1216725 SAV_6349 Streptomyces avermitilis MA-4680 protein NP_827525.1 7616478 D 227882 CDS NP_827526.1 29832892 1216726 7618443..7620026 1 NC_003155.4 PF05731: TROVE domain; ribonucleoprotein-related protein 7620026 1216726 SAV_6350 Streptomyces avermitilis MA-4680 ribonucleoprotein-related protein NP_827526.1 7618443 D 227882 CDS NP_827527.1 29832893 1216727 complement(7620108..7621562) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 7621562 1216727 SAV_6351 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_827527.1 7620108 R 227882 CDS NP_827528.1 29832894 1216728 7621700..7622305 1 NC_003155.4 TetR family transcriptional regulator 7622305 1216728 SAV_6352 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_827528.1 7621700 D 227882 CDS NP_827529.1 29832895 1216729 complement(7622368..7623576) 1 NC_003155.4 PF02342: Bacterial stress protein; transport associated protein 7623576 1216729 SAV_6353 Streptomyces avermitilis MA-4680 transport associated protein NP_827529.1 7622368 R 227882 CDS NP_827530.1 29832896 1216730 complement(7623726..7624715) 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; zinc-binding dehydrogenase 7624715 1216730 SAV_6354 Streptomyces avermitilis MA-4680 zinc-binding dehydrogenase NP_827530.1 7623726 R 227882 CDS NP_827531.1 29832897 1216731 complement(7624712..7625581) 1 NC_003155.4 maltose/mannitol transport protein; sugar ABC transporter permease 7625581 1216731 SAV_6355 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_827531.1 7624712 R 227882 CDS NP_827532.1 29832898 1216732 complement(7625578..7626516) 1 NC_003155.4 maltose/mannitol transport protein; sugar ABC transporter permease 7626516 1216732 SAV_6356 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_827532.1 7625578 R 227882 CDS NP_827533.1 29832899 1216733 complement(7626513..7627883) 1 NC_003155.4 maltose/mannitol transport protein; sugar ABC transporter substrate-binding protein 7627883 1216733 SAV_6357 Streptomyces avermitilis MA-4680 sugar ABC transporter substrate-binding protein NP_827533.1 7626513 R 227882 CDS NP_827534.1 29832900 1216734 complement(7627994..7628782) 1 NC_003155.4 DeoR family transcriptional regulator 7628782 1216734 SAV_6358 Streptomyces avermitilis MA-4680 DeoR family transcriptional regulator NP_827534.1 7627994 R 227882 CDS NP_827535.1 29832901 1216735 complement(7629040..7629849) 1 NC_003155.4 PF01370: NAD dependent epimerase/dehydratase family; hypothetical protein 7629849 1216735 SAV_6359 Streptomyces avermitilis MA-4680 hypothetical protein NP_827535.1 7629040 R 227882 CDS NP_827536.1 29832902 1211467 7630125..7631066 1 NC_003155.4 catalyzes the formation of 2,5-dioxopentanoate from 5-dehydro-4-deoxy-D-glucarate; 5-dehydro-4-deoxyglucarate dehydratase 7631066 dapA6 1211467 dapA6 Streptomyces avermitilis MA-4680 5-dehydro-4-deoxyglucarate dehydratase NP_827536.1 7630125 D 227882 CDS NP_827537.1 29832903 1216736 7631063..7632295 1 NC_003155.4 alanine-rich protein 7632295 1216736 SAV_6361 Streptomyces avermitilis MA-4680 alanine-rich protein NP_827537.1 7631063 D 227882 CDS NP_827538.1 29832904 1216737 complement(7632199..7633401) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; integral membrane efflux protein 7633401 1216737 SAV_6362 Streptomyces avermitilis MA-4680 integral membrane efflux protein NP_827538.1 7632199 R 227882 CDS NP_827539.1 29832905 1216738 7633567..7634157 1 NC_003155.4 hypothetical protein 7634157 1216738 SAV_6363 Streptomyces avermitilis MA-4680 hypothetical protein NP_827539.1 7633567 D 227882 CDS NP_827540.1 29832906 1216739 7634272..7635024 1 NC_003155.4 PF00753: Metallo-beta-lactamase superfamily; hypothetical protein 7635024 1216739 SAV_6364 Streptomyces avermitilis MA-4680 hypothetical protein NP_827540.1 7634272 D 227882 CDS NP_827541.1 29832907 1216740 7635144..7635800 1 NC_003155.4 GntR family transcriptional regulator 7635800 1216740 SAV_6365 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_827541.1 7635144 D 227882 CDS NP_827542.1 29832908 1211468 7635797..7636705 1 NC_003155.4 dihydrodipicolinate synthase 7636705 dapA7 1211468 dapA7 Streptomyces avermitilis MA-4680 dihydrodipicolinate synthase NP_827542.1 7635797 D 227882 CDS NP_827543.1 29832909 1211469 7636693..7638432 1 NC_003155.4 catalyzes the formation of 3-methyl-2-oxobutanoate from 2,3,-dihydroxy-3-methylbutanoate; dihydroxy-acid dehydratase 7638432 ilvD2 1211469 ilvD2 Streptomyces avermitilis MA-4680 dihydroxy-acid dehydratase NP_827543.1 7636693 D 227882 CDS NP_827544.1 29832910 1216741 7638581..7639525 1 NC_003155.4 ABC transporter permease 7639525 1216741 SAV_6368 Streptomyces avermitilis MA-4680 ABC transporter permease NP_827544.1 7638581 D 227882 CDS NP_827545.1 29832911 1216742 7639522..7640424 1 NC_003155.4 ABC transporter permease 7640424 1216742 SAV_6369 Streptomyces avermitilis MA-4680 ABC transporter permease NP_827545.1 7639522 D 227882 CDS NP_827546.1 29832912 1216743 7640520..7641704 1 NC_003155.4 PF01408: Oxidoreductase family, NAD-binding Rossmann fold; oxidoreductase 7641704 1216743 SAV_6370 Streptomyces avermitilis MA-4680 oxidoreductase NP_827546.1 7640520 D 227882 CDS NP_827547.1 29832913 1216744 7641701..7642567 1 NC_003155.4 hypothetical protein 7642567 1216744 SAV_6371 Streptomyces avermitilis MA-4680 hypothetical protein NP_827547.1 7641701 D 227882 CDS NP_827548.1 29832914 1216745 7642564..7643874 1 NC_003155.4 xylanase 7643874 1216745 SAV_6372 Streptomyces avermitilis MA-4680 xylanase NP_827548.1 7642564 D 227882 CDS NP_827549.1 29832915 1216746 7643983..7645320 1 NC_003155.4 PF00497: Bacterial extracellular solute-binding proteins, family 3; sugar-binding protein 7645320 1216746 SAV_6373 Streptomyces avermitilis MA-4680 sugar-binding protein NP_827549.1 7643983 D 227882 CDS NP_827550.1 29832916 1216747 7645485..7646285 1 NC_003155.4 PF00657: GDSL-like Lipase/Acylhydrolase; rhamnogalacturonan acetylesterase 7646285 1216747 SAV_6374 Streptomyces avermitilis MA-4680 rhamnogalacturonan acetylesterase NP_827550.1 7645485 D 227882 CDS NP_827551.1 29832917 1216748 7646360..7647691 1 NC_003155.4 pectate lyase 7647691 1216748 SAV_6375 Streptomyces avermitilis MA-4680 pectate lyase NP_827551.1 7646360 D 227882 CDS NP_827552.1 29832918 1216749 7647694..7648833 1 NC_003155.4 pectinesterase 7648833 1216749 SAV_6376 Streptomyces avermitilis MA-4680 pectinesterase NP_827552.1 7647694 D 227882 CDS NP_827553.1 29832919 1216750 7648805..7649860 1 NC_003155.4 pectinesterase 7649860 1216750 SAV_6377 Streptomyces avermitilis MA-4680 pectinesterase NP_827553.1 7648805 D 227882 CDS NP_827554.1 29832920 1216751 7649923..7651035 1 NC_003155.4 pectate lyase 7651035 1216751 SAV_6378 Streptomyces avermitilis MA-4680 pectate lyase NP_827554.1 7649923 D 227882 CDS NP_827555.1 29832921 1216752 complement(7651127..7651498) 1 NC_003155.4 hypothetical protein 7651498 1216752 SAV_6379 Streptomyces avermitilis MA-4680 hypothetical protein NP_827555.1 7651127 R 227882 CDS NP_827556.1 29832922 1216753 7651723..7652517 1 NC_003155.4 acid phosphatase 7652517 1216753 SAV_6380 Streptomyces avermitilis MA-4680 acid phosphatase NP_827556.1 7651723 D 227882 CDS NP_827557.1 29832923 1211470 complement(7652721..7654928) 1 NC_003155.4 endo-1,4-beta-xylanase 7654928 xynD 1211470 xynD Streptomyces avermitilis MA-4680 endo-1,4-beta-xylanase NP_827557.1 7652721 R 227882 CDS NP_827558.1 29832924 1216754 7655170..7656327 1 NC_003155.4 pectate lyase 7656327 1216754 SAV_6382 Streptomyces avermitilis MA-4680 pectate lyase NP_827558.1 7655170 D 227882 CDS NP_827559.1 29832925 1216755 complement(7656496..7657326) 1 NC_003155.4 pectate lyase 7657326 1216755 SAV_6383 Streptomyces avermitilis MA-4680 pectate lyase NP_827559.1 7656496 R 227882 CDS NP_827560.1 29832926 1216756 complement(7657426..7658292) 1 NC_003155.4 hypothetical protein 7658292 1216756 SAV_6384 Streptomyces avermitilis MA-4680 hypothetical protein NP_827560.1 7657426 R 227882 CDS NP_827561.1 29832927 1211471 complement(7658289..7658855) 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 7658855 sig52 1211471 sig52 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_827561.1 7658289 R 227882 CDS NP_827562.1 29832928 1211472 7659113..7660564 1 NC_003155.4 hypoxanthine/guanine permease 7660564 pbuG 1211472 pbuG Streptomyces avermitilis MA-4680 hypoxanthine/guanine permease NP_827562.1 7659113 D 227882 CDS NP_827563.1 29832929 1211473 complement(7660632..7662083) 1 NC_003155.4 PF00905: Penicillin binding protein transpeptidase domain; penicillin-binding protein 7662083 pbp11 1211473 pbp11 Streptomyces avermitilis MA-4680 penicillin-binding protein NP_827563.1 7660632 R 227882 CDS NP_827564.1 29832930 1216757 complement(7662205..7662978) 1 NC_003155.4 IclR family transcriptional regulator 7662978 1216757 SAV_6388 Streptomyces avermitilis MA-4680 IclR family transcriptional regulator NP_827564.1 7662205 R 227882 CDS NP_827565.1 29832931 1216758 7663109..7664638 1 NC_003155.4 aldehyde dehydrogenase 7664638 1216758 SAV_6389 Streptomyces avermitilis MA-4680 aldehyde dehydrogenase NP_827565.1 7663109 D 227882 CDS NP_827566.1 29832932 1216759 7664785..7665393 1 NC_003155.4 PF07081: Protein of unknown function (DUF1349); hypothetical protein 7665393 1216759 SAV_6390 Streptomyces avermitilis MA-4680 hypothetical protein NP_827566.1 7664785 D 227882 CDS NP_827567.1 29832933 1216760 complement(7665376..7666779) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; drug/proton antiporter 7666779 1216760 SAV_6391 Streptomyces avermitilis MA-4680 drug/proton antiporter NP_827567.1 7665376 R 227882 CDS NP_827568.1 29832934 1216761 7666842..7667849 1 NC_003155.4 AraC family transcription regulator 7667849 1216761 SAV_6392 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_827568.1 7666842 D 227882 CDS NP_827569.1 29832935 1216762 7667912..7668628 1 NC_003155.4 PF01323: DSBA-like thioredoxin domain; protein dithiol-disulfide isomerase 7668628 frnE 1216762 frnE Streptomyces avermitilis MA-4680 protein dithiol-disulfide isomerase NP_827569.1 7667912 D 227882 CDS NP_827570.1 29832936 1216763 7668699..7669805 1 NC_003155.4 PF00266: Aminotransferase class-V; hypothetical protein 7669805 1216763 SAV_6394 Streptomyces avermitilis MA-4680 hypothetical protein NP_827570.1 7668699 D 227882 CDS NP_827571.1 29832937 1216764 complement(7670236..7671078) 1 NC_003155.4 ectoine cluster, PF05721: Phytanoyl-CoA dioxygenase (PhyH); ectoine hydroxylase 7671078 ectD 1216764 ectD Streptomyces avermitilis MA-4680 ectoine hydroxylase NP_827571.1 7670236 R 227882 CDS NP_827572.1 29832938 1216765 complement(7671129..7671533) 1 NC_003155.4 N-acetyldiaminobutyrate dehydratase; catalyzes the formation of the osmoprotectant ecotoine from gamma-N-acetyl-alpha,gamma-diaminobutyric acid; L-ectoine synthase 7671533 ectC 1216765 ectC Streptomyces avermitilis MA-4680 L-ectoine synthase NP_827572.1 7671129 R 227882 CDS NP_827573.1 29832939 1216766 complement(7671591..7672862) 1 NC_003155.4 catalyzes the reversible formation of diaminobutyrate and 2-oxoglutarate from glutamate and L-aspartic beta-semialdehyde; diaminobutyrate--2-oxoglutarate aminotransferase 7672862 ectB 1216766 ectB Streptomyces avermitilis MA-4680 diaminobutyrate--2-oxoglutarate aminotransferase NP_827573.1 7671591 R 227882 CDS NP_827574.1 29832940 1216767 complement(7672892..7673431) 1 NC_003155.4 ectoine cluster, PF00583: Acetyltransferase (GNAT) family; L-2,4-diaminobutyrate acetyltransferase 7673431 ectA 1216767 ectA Streptomyces avermitilis MA-4680 L-2,4-diaminobutyrate acetyltransferase NP_827574.1 7672892 R 227882 CDS NP_827575.1 29832941 1211474 complement(7673797..7674927) 1 NC_003155.4 aminotransferase class-V; aspartate aminotransferase 7674927 aspC2 1211474 aspC2 Streptomyces avermitilis MA-4680 aspartate aminotransferase NP_827575.1 7673797 R 227882 CDS NP_827576.1 29832942 1216768 7675117..7675965 1 NC_003155.4 ABC transporter substrate-binding protein 7675965 1216768 SAV_6400 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_827576.1 7675117 D 227882 CDS NP_827577.1 29832943 1216769 7675962..7676795 1 NC_003155.4 ABC transporter permease 7676795 1216769 SAV_6401 Streptomyces avermitilis MA-4680 ABC transporter permease NP_827577.1 7675962 D 227882 CDS NP_827578.1 29832944 1216770 7676792..7677595 1 NC_003155.4 ABC transporter ATP-binding protein 7677595 1216770 SAV_6402 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_827578.1 7676792 D 227882 CDS NP_827579.1 29832945 1216771 7677606..7678697 1 NC_003155.4 PF01979: Amidohydrolase family; hypothetical protein 7678697 1216771 SAV_6403 Streptomyces avermitilis MA-4680 hypothetical protein NP_827579.1 7677606 D 227882 CDS NP_827580.1 29832946 1216772 complement(7678794..7679774) 1 NC_003155.4 cobalamin biosynthesis; hypothetical protein 7679774 cobC 1216772 cobC Streptomyces avermitilis MA-4680 hypothetical protein NP_827580.1 7678794 R 227882 CDS NP_827581.1 29832947 1211475 complement(7679854..7680792) 1 NC_003155.4 cobalamin biosynthesis (other possible function is involved in expression of nickel-containing superoxide dismutase); metal binding protein 7680792 cbiX 1211475 cbiX Streptomyces avermitilis MA-4680 metal binding protein NP_827581.1 7679854 R 227882 CDS NP_827582.1 29832948 1211476 complement(7680789..7681403) 1 NC_003155.4 cobalamin biosynthesis; precorrin-8X methylmutase 7681403 cobH 1211476 cobH Streptomyces avermitilis MA-4680 precorrin-8X methylmutase NP_827582.1 7680789 R 227882 CDS NP_827583.1 29832949 1211477 complement(7681400..7683001) 1 NC_003155.4 CbiG/H-fusion; cobalamin biosynthesis; precorrin methylase 7683001 cobJ 1211477 cobJ Streptomyces avermitilis MA-4680 precorrin methylase NP_827583.1 7681400 R 227882 CDS NP_827584.1 29832950 1211478 complement(7683079..7684329) 1 NC_003155.4 cobalamin biosynthesis; precorrin-6Y C5,15-methyltransferase 7684329 cobL1 1211478 cobL1 Streptomyces avermitilis MA-4680 precorrin-6Y C5,15-methyltransferase NP_827584.1 7683079 R 227882 CDS NP_827585.1 29832951 1211479 complement(7684326..7685150) 1 NC_003155.4 cobalamin biosynthesis; precorrin-4 C11-methyltransferase 7685150 cobM 1211479 cobM Streptomyces avermitilis MA-4680 precorrin-4 C11-methyltransferase NP_827585.1 7684326 R 227882 CDS NP_827586.1 29832952 1216773 7685255..7685983 1 NC_003155.4 permease 7685983 1216773 SAV_6410 Streptomyces avermitilis MA-4680 permease NP_827586.1 7685255 D 227882 CDS NP_827587.1 29832953 1211480 complement(7686007..7686756) 1 NC_003155.4 cobalamin biosynthesis; precorrin-2 C20-methyltransferase 7686756 cobI 1211480 cobI Streptomyces avermitilis MA-4680 precorrin-2 C20-methyltransferase NP_827587.1 7686007 R 227882 CDS NP_827588.1 29832954 1211481 complement(7686753..7688117) 1 NC_003155.4 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid; cobyrinic acid a,c-diamide synthase 7688117 cobB 1211481 cobB Streptomyces avermitilis MA-4680 cobyrinic acid a,c-diamide synthase NP_827588.1 7686753 R 227882 CDS NP_827589.1 29832955 1211482 complement(7688111..7688710) 1 NC_003155.4 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 7688710 cobA 1211482 cobA Streptomyces avermitilis MA-4680 cob(I)yrinic acid a,c-diamide adenosyltransferase NP_827589.1 7688111 R 227882 CDS NP_827590.1 29832956 1216774 complement(7688710..7690779) 1 NC_003155.4 cobalamin biosynthesis porphyrin-related; magnesium-chelatase subunit 7690779 chlI 1216774 chlI Streptomyces avermitilis MA-4680 magnesium-chelatase subunit NP_827590.1 7688710 R 227882 CDS NP_827591.1 29832957 1211483 complement(7690776..7694429) 1 NC_003155.4 with CobST catalyzes the formation of cobyrinic acid a,c-diamide from hydrogenobyrinic acid a,c-diamide in an ATP-dependent manner; involved in porphyrin and chlorophyll metabolism; vitamin B12 metabolism; cobaltochelatase subunit CobN 7694429 cobN 1211483 cobN Streptomyces avermitilis MA-4680 cobaltochelatase subunit CobN NP_827591.1 7690776 R 227882 CDS NP_827592.1 29832958 1211484 complement(7694426..7695934) 1 NC_003155.4 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation; cobyric acid synthase 7695934 cobQ1 1211484 cobQ1 Streptomyces avermitilis MA-4680 cobyric acid synthase NP_827592.1 7694426 R 227882 CDS NP_827593.1 29832959 1211485 complement(7695931..7696872) 1 NC_003155.4 CobD; CbiD in Salmonella; converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group; cobalamin biosynthesis protein 7696872 cobD 1211485 cobD Streptomyces avermitilis MA-4680 cobalamin biosynthesis protein NP_827593.1 7695931 R 227882 CDS NP_827594.1 29832960 1216775 complement(7697331..7697546) 1 NC_003155.4 protein 7697546 1216775 SAV_6418 Streptomyces avermitilis MA-4680 protein NP_827594.1 7697331 R 227882 CDS NP_827595.1 29832961 1216776 complement(7697559..7698812) 1 NC_003155.4 low-affinity inorganic phosphate transporter 7698812 pitH2 1216776 pitH2 Streptomyces avermitilis MA-4680 low-affinity inorganic phosphate transporter NP_827595.1 7697559 R 227882 CDS NP_827596.1 29832962 1216777 complement(7699003..7699746) 1 NC_003155.4 PF01183: Glycosyl hydrolases family 25; lysozyme precursor 7699746 1216777 SAV_6420 Streptomyces avermitilis MA-4680 lysozyme precursor NP_827596.1 7699003 R 227882 CDS NP_827597.1 29832963 1216778 7699943..7700668 1 NC_003155.4 fuculose-1-phosphate aldolase 7700668 fucA2 1216778 fucA2 Streptomyces avermitilis MA-4680 fuculose-1-phosphate aldolase NP_827597.1 7699943 D 227882 CDS NP_827598.1 29832964 1216779 7700865..7701992 1 NC_003155.4 PF00326: Prolyl oligopeptidase family; protein 7701992 1216779 SAV_6422 Streptomyces avermitilis MA-4680 protein NP_827598.1 7700865 D 227882 CDS NP_827599.1 29832965 1216780 7702240..7703607 1 NC_003155.4 hypothetical protein 7703607 1216780 SAV_6423 Streptomyces avermitilis MA-4680 hypothetical protein NP_827599.1 7702240 D 227882 CDS NP_827600.1 29832966 1216781 complement(7703659..7704081) 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein 7704081 1216781 SAV_6424 Streptomyces avermitilis MA-4680 hypothetical protein NP_827600.1 7703659 R 227882 CDS NP_827601.1 29832967 1216782 7704121..7705302 1 NC_003155.4 hypothetical protein 7705302 1216782 SAV_6425 Streptomyces avermitilis MA-4680 hypothetical protein NP_827601.1 7704121 D 227882 CDS NP_827602.1 29832968 1216783 7705394..7706992 1 NC_003155.4 ABC transporter ATP-binding protein 7706992 1216783 SAV_6426 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_827602.1 7705394 D 227882 CDS NP_827603.1 29832969 1216784 7707369..7707590 1 NC_003155.4 transcriptional regulator 7707590 1216784 SAV_6427 Streptomyces avermitilis MA-4680 transcriptional regulator NP_827603.1 7707369 D 227882 CDS NP_827604.1 29832970 1211486 7707734..7708567 1 NC_003155.4 enoyl-CoA hydratase/isomerase 7708567 echA14 1211486 echA14 Streptomyces avermitilis MA-4680 enoyl-CoA hydratase/isomerase NP_827604.1 7707734 D 227882 CDS NP_827605.1 29832971 1216785 complement(7708564..7709304) 1 NC_003155.4 hypothetical protein 7709304 1216785 SAV_6429 Streptomyces avermitilis MA-4680 hypothetical protein NP_827605.1 7708564 R 227882 CDS NP_827606.1 29832972 1216786 7709390..7709872 1 NC_003155.4 PF03780: Protein of unknown function (DUF322); stress-like protein 7709872 1216786 SAV_6430 Streptomyces avermitilis MA-4680 stress-like protein NP_827606.1 7709390 D 227882 CDS NP_827607.1 29832973 1216787 7709906..7710091 1 NC_003155.4 hypothetical protein 7710091 1216787 SAV_6431 Streptomyces avermitilis MA-4680 hypothetical protein NP_827607.1 7709906 D 227882 CDS NP_827608.1 29832974 1216788 7710095..7710496 1 NC_003155.4 PF03780: Protein of unknown function (DUF322); hypothetical protein 7710496 1216788 SAV_6432 Streptomyces avermitilis MA-4680 hypothetical protein NP_827608.1 7710095 D 227882 CDS NP_827609.1 29832975 1216789 7710493..7711179 1 NC_003155.4 hypothetical protein 7711179 1216789 SAV_6433 Streptomyces avermitilis MA-4680 hypothetical protein NP_827609.1 7710493 D 227882 CDS NP_827610.1 29832976 1216790 7711176..7711763 1 NC_003155.4 hypothetical protein 7711763 1216790 SAV_6434 Streptomyces avermitilis MA-4680 hypothetical protein NP_827610.1 7711176 D 227882 CDS NP_827611.1 29832977 1216791 complement(7711830..7712585) 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 7712585 1216791 SAV_6435 Streptomyces avermitilis MA-4680 dehydrogenase NP_827611.1 7711830 R 227882 CDS NP_827612.1 29832978 1216792 complement(7712591..7714402) 1 NC_003155.4 PF00723: Glycosyl hydrolases family 15; glycosyl hydrolase 7714402 1216792 SAV_6436 Streptomyces avermitilis MA-4680 glycosyl hydrolase NP_827612.1 7712591 R 227882 CDS NP_827613.1 29832979 1216793 complement(7714575..7715372) 1 NC_003155.4 hypothetical protein 7715372 1216793 SAV_6437 Streptomyces avermitilis MA-4680 hypothetical protein NP_827613.1 7714575 R 227882 CDS NP_827614.1 29832980 1216794 complement(7715441..7715674) 1 NC_003155.4 hypothetical protein 7715674 1216794 SAV_6438 Streptomyces avermitilis MA-4680 hypothetical protein NP_827614.1 7715441 R 227882 CDS NP_827615.1 29832981 1211487 complement(7715780..7716757) 1 NC_003155.4 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 7716757 dnaQ1 1211487 dnaQ1 Streptomyces avermitilis MA-4680 DNA polymerase III subunit epsilon NP_827615.1 7715780 R 227882 CDS NP_827616.1 29832982 1216795 complement(7716812..7717504) 1 NC_003155.4 TetR family transcriptional regulator 7717504 1216795 SAV_6440 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_827616.1 7716812 R 227882 CDS NP_827617.1 29832983 1216796 7717562..7718359 1 NC_003155.4 PF06314: Acetoacetate decarboxylase (ADC); hypothetical protein 7718359 1216796 SAV_6441 Streptomyces avermitilis MA-4680 hypothetical protein NP_827617.1 7717562 D 227882 CDS NP_827618.1 29832984 1216797 7718359..7719243 1 NC_003155.4 probable dehydrogenase; hypothetical protein 7719243 1216797 SAV_6442 Streptomyces avermitilis MA-4680 hypothetical protein NP_827618.1 7718359 D 227882 CDS NP_827619.1 29832985 1216798 7719251..7720567 1 NC_003155.4 PF04909: Amidohydrolase; amidohydrolase 7720567 1216798 SAV_6443 Streptomyces avermitilis MA-4680 amidohydrolase NP_827619.1 7719251 D 227882 CDS NP_827620.1 29832986 1216799 7720564..7721793 1 NC_003155.4 PF04909: Amidohydrolase; amidohydrolase 7721793 1216799 SAV_6444 Streptomyces avermitilis MA-4680 amidohydrolase NP_827620.1 7720564 D 227882 CDS NP_827621.1 29832987 1216800 7721818..7722528 1 NC_003155.4 PF01988: Integral membrane protein DUF125; hypothetical protein 7722528 1216800 SAV_6445 Streptomyces avermitilis MA-4680 hypothetical protein NP_827621.1 7721818 D 227882 CDS NP_827622.1 29832988 1216801 7722672..7723541 1 NC_003155.4 PF01598: Sterol desaturase; sterol desaturase-related protein 7723541 1216801 SAV_6446 Streptomyces avermitilis MA-4680 sterol desaturase-related protein NP_827622.1 7722672 D 227882 CDS NP_827623.1 29832989 1216802 7723538..7724215 1 NC_003155.4 hypothetical protein 7724215 1216802 SAV_6447 Streptomyces avermitilis MA-4680 hypothetical protein NP_827623.1 7723538 D 227882 CDS NP_827624.1 29832990 1216803 7724255..7725298 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; alcohol dehydrogenase 7725298 adhA8 1216803 adhA8 Streptomyces avermitilis MA-4680 alcohol dehydrogenase NP_827624.1 7724255 D 227882 CDS NP_827625.1 29832991 1216804 complement(7725302..7726354) 1 NC_003155.4 PF05425: Copper resistance protein D; hypothetical protein 7726354 1216804 SAV_6449 Streptomyces avermitilis MA-4680 hypothetical protein NP_827625.1 7725302 R 227882 CDS NP_827626.1 29832992 1216805 complement(7726498..7728009) 1 NC_003155.4 PF02515: CoA-transferase family III; hypothetical protein 7728009 1216805 SAV_6450 Streptomyces avermitilis MA-4680 hypothetical protein NP_827626.1 7726498 R 227882 CDS NP_827627.1 29832993 1216806 complement(7728112..7729635) 1 NC_003155.4 PF00082: Subtilase family; subtilisin-like protease 7729635 1216806 SAV_6451 Streptomyces avermitilis MA-4680 subtilisin-like protease NP_827627.1 7728112 R 227882 CDS NP_827628.1 29832994 1216807 complement(7729762..7731297) 1 NC_003155.4 PF00082: Subtilase family; subtilisin-like protease 7731297 1216807 SAV_6452 Streptomyces avermitilis MA-4680 subtilisin-like protease NP_827628.1 7729762 R 227882 CDS NP_827629.1 29832995 1216808 7731675..7732031 1 NC_003155.4 PF04341: Protein of unknown function, DUF485; hypothetical protein 7732031 1216808 SAV_6453 Streptomyces avermitilis MA-4680 hypothetical protein NP_827629.1 7731675 D 227882 CDS NP_827630.1 29832996 1216809 7732028..7733677 1 NC_003155.4 PF00474: Sodium:solute symporter family; sodium:solute symporter 7733677 1216809 SAV_6454 Streptomyces avermitilis MA-4680 sodium:solute symporter NP_827630.1 7732028 D 227882 CDS NP_827631.1 29832997 1211488 7733782..7734813 1 NC_003155.4 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 7734813 moaA 1211488 moaA Streptomyces avermitilis MA-4680 molybdenum cofactor biosynthesis protein A NP_827631.1 7733782 D 227882 CDS NP_827632.1 29832998 1216810 complement(7734841..7735083) 1 NC_003155.4 hypothetical protein 7735083 1216810 SAV_6456 Streptomyces avermitilis MA-4680 hypothetical protein NP_827632.1 7734841 R 227882 CDS NP_827633.1 29832999 1216811 complement(7735368..7735847) 1 NC_003155.4 hypothetical protein 7735847 1216811 SAV_6457 Streptomyces avermitilis MA-4680 hypothetical protein NP_827633.1 7735368 R 227882 CDS NP_827634.1 29833000 1216812 7736010..7736285 1 NC_003155.4 transglycosylase associated protein 7736285 1216812 SAV_6458 Streptomyces avermitilis MA-4680 transglycosylase associated protein NP_827634.1 7736010 D 227882 CDS NP_827635.1 29833001 1211489 complement(7736361..7737629) 1 NC_003155.4 tyrosyl-tRNA synthetase 7737629 tyrS 1211489 tyrS Streptomyces avermitilis MA-4680 tyrosyl-tRNA synthetase NP_827635.1 7736361 R 227882 CDS NP_827636.1 29833002 1216813 complement(7737674..7739068) 1 NC_003155.4 PF01523: Putative modulator of DNA gyrase; hypothetical protein 7739068 1216813 SAV_6460 Streptomyces avermitilis MA-4680 hypothetical protein NP_827636.1 7737674 R 227882 CDS NP_827637.1 29833003 1216814 complement(7739065..7740588) 1 NC_003155.4 PF01523: Putative modulator of DNA gyrase; modulator of DNA gyrase 7740588 tldD 1216814 tldD Streptomyces avermitilis MA-4680 modulator of DNA gyrase NP_827637.1 7739065 R 227882 CDS NP_827638.1 29833004 1211490 7740859..7741578 1 NC_003155.4 PF00106: short chain dehydrogenase; 3-oxoacyl-ACP reductase 7741578 fabG7 1211490 fabG7 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP reductase NP_827638.1 7740859 D 227882 CDS NP_827639.1 29833005 1211491 7741584..7742351 1 NC_003155.4 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-ACP reductase 7742351 fabI1 1211491 fabI1 Streptomyces avermitilis MA-4680 enoyl-ACP reductase NP_827639.1 7741584 D 227882 CDS NP_827640.1 29833006 1216815 7742356..7742883 1 NC_003155.4 hypothetical protein 7742883 1216815 SAV_6464 Streptomyces avermitilis MA-4680 hypothetical protein NP_827640.1 7742356 D 227882 CDS NP_827641.1 29833007 1216816 complement(7742893..7743588) 1 NC_003155.4 GntR family transcriptional regulator 7743588 1216816 SAV_6465 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_827641.1 7742893 R 227882 CDS NP_827642.1 29833008 1216817 7743701..7745041 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane transport protein 7745041 1216817 SAV_6466 Streptomyces avermitilis MA-4680 transmembrane transport protein NP_827642.1 7743701 D 227882 CDS NP_827643.1 29833009 1216818 7745073..7745273 1 NC_003155.4 hypothetical protein 7745273 1216818 SAV_6467 Streptomyces avermitilis MA-4680 hypothetical protein NP_827643.1 7745073 D 227882 CDS NP_827644.1 29833010 1216819 7745539..7745751 1 NC_003155.4 hypothetical protein 7745751 1216819 SAV_6468 Streptomyces avermitilis MA-4680 hypothetical protein NP_827644.1 7745539 D 227882 CDS NP_827645.1 29833011 1216820 7745840..7746358 1 NC_003155.4 PF00300: Phosphoglycerate mutase family; hypothetical protein 7746358 1216820 SAV_6469 Streptomyces avermitilis MA-4680 hypothetical protein NP_827645.1 7745840 D 227882 CDS NP_827646.1 29833012 1211492 complement(7746453..7747667) 1 NC_003155.4 3-phosphoserine phosphatase 7747667 serB2 1211492 serB2 Streptomyces avermitilis MA-4680 3-phosphoserine phosphatase NP_827646.1 7746453 R 227882 CDS NP_827647.1 29833013 1216821 complement(7748068..7750083) 1 NC_003155.4 hypothetical protein 7750083 1216821 SAV_6471 Streptomyces avermitilis MA-4680 hypothetical protein NP_827647.1 7748068 R 227882 CDS NP_827648.1 29833014 1216822 7750323..7752854 1 NC_003155.4 ABC transporter ATP-binding protein 7752854 1216822 SAV_6472 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_827648.1 7750323 D 227882 CDS NP_827649.1 29833015 1216823 complement(7752952..7753695) 1 NC_003155.4 PF01464: Transglycosylase SLT domain; hypothetical protein 7753695 1216823 SAV_6473 Streptomyces avermitilis MA-4680 hypothetical protein NP_827649.1 7752952 R 227882 CDS NP_827650.1 29833016 1211493 complement(7753933..7755165) 1 NC_003155.4 S-adenosylmethionine:tRNA ribosyltransferase-isomerase 7755165 queA 1211493 queA Streptomyces avermitilis MA-4680 S-adenosylmethionine:tRNA ribosyltransferase-isomerase NP_827650.1 7753933 R 227882 CDS NP_827651.1 29833017 1216824 complement(7755174..7755878) 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 7755878 1216824 SAV_6475 Streptomyces avermitilis MA-4680 dehydrogenase NP_827651.1 7755174 R 227882 CDS NP_827652.1 29833018 1216825 7756067..7757212 1 NC_003155.4 two-component system sensor kinase 7757212 1216825 SAV_6476 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_827652.1 7756067 D 227882 CDS NP_827653.1 29833019 1216826 7757205..7757846 1 NC_003155.4 two-component system response regulator 7757846 1216826 SAV_6477 Streptomyces avermitilis MA-4680 two-component system response regulator NP_827653.1 7757205 D 227882 CDS NP_827654.1 29833020 1216827 7758074..7758319 1 NC_003155.4 PF03777: Small domain (DUF320); protein 7758319 1216827 SAV_6478 Streptomyces avermitilis MA-4680 protein NP_827654.1 7758074 D 227882 CDS NP_827655.1 29833021 1216828 complement(7758576..7759364) 1 NC_003155.4 hypothetical protein 7759364 1216828 SAV_6479 Streptomyces avermitilis MA-4680 hypothetical protein NP_827655.1 7758576 R 227882 CDS NP_827656.1 29833022 1216829 7759495..7760286 1 NC_003155.4 ABC transporter ATP-binding protein 7760286 1216829 SAV_6480 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_827656.1 7759495 D 227882 CDS NP_827657.1 29833023 1216830 7760380..7760811 1 NC_003155.4 hypothetical protein 7760811 1216830 SAV_6481 Streptomyces avermitilis MA-4680 hypothetical protein NP_827657.1 7760380 D 227882 CDS NP_827658.1 29833024 1216831 7760942..7761892 1 NC_003155.4 PF01145: SPFH domain / Band 7 family; protein 7761892 1216831 SAV_6482 Streptomyces avermitilis MA-4680 protein NP_827658.1 7760942 D 227882 CDS NP_827659.1 29833025 1216832 complement(7761999..7762505) 1 NC_003155.4 PF01844: HNH endonuclease; endonuclease 7762505 1216832 SAV_6483 Streptomyces avermitilis MA-4680 endonuclease NP_827659.1 7761999 R 227882 CDS NP_827660.1 29833026 1216833 complement(7762650..7763189) 1 NC_003155.4 phospholipid-binding protein 7763189 1216833 SAV_6484 Streptomyces avermitilis MA-4680 phospholipid-binding protein NP_827660.1 7762650 R 227882 CDS NP_827661.1 29833027 1216834 complement(7763250..7764035) 1 NC_003155.4 PF07070: SpoOM protein; sporulation-control protein 7764035 1216834 SAV_6485 Streptomyces avermitilis MA-4680 sporulation-control protein NP_827661.1 7763250 R 227882 CDS NP_827662.1 29833028 1216835 7764232..7764873 1 NC_003155.4 responsible for recognizing base lesions in the genome and initiating base excision DNA repair; 3-methyladenine DNA glycosylase 7764873 1216835 SAV_6486 Streptomyces avermitilis MA-4680 3-methyladenine DNA glycosylase NP_827662.1 7764232 D 227882 CDS NP_827663.1 29833029 1216836 7770872..7772263 1 NC_003155.4 hypothetical protein 7772263 1216836 SAV_6487 Streptomyces avermitilis MA-4680 hypothetical protein NP_827663.1 7770872 D 227882 CDS NP_827664.1 29833030 1216837 7772308..7773084 1 NC_003155.4 hypothetical protein 7773084 1216837 SAV_6488 Streptomyces avermitilis MA-4680 hypothetical protein NP_827664.1 7772308 D 227882 CDS NP_827665.1 29833031 1216838 complement(7773149..7774441) 1 NC_003155.4 PF06245: Protein of unknown function (DUF1015); hypothetical protein 7774441 1216838 SAV_6489 Streptomyces avermitilis MA-4680 hypothetical protein NP_827665.1 7773149 R 227882 CDS NP_827666.1 29833032 1216839 7774522..7775550 1 NC_003155.4 PF00702: haloacid dehalogenase-like hydrolase; hydrolase 7775550 1216839 SAV_6490 Streptomyces avermitilis MA-4680 hydrolase NP_827666.1 7774522 D 227882 CDS NP_827667.1 29833033 1216840 7775720..7776763 1 NC_003155.4 iron-siderophore uptake system transmembrane component; ferrichrome ABC transporter permease 7776763 fepD 1216840 fepD Streptomyces avermitilis MA-4680 ferrichrome ABC transporter permease NP_827667.1 7775720 D 227882 CDS NP_827668.1 29833034 1211497 7776760..7777818 1 NC_003155.4 iron-siderophore uptake system transmembrane component; ferrichrome ABC transporter permease 7777818 fepG 1211497 fepG Streptomyces avermitilis MA-4680 ferrichrome ABC transporter permease NP_827668.1 7776760 D 227882 CDS NP_827669.1 29833035 1216841 7777815..7778702 1 NC_003155.4 iron-siderophore uptake system transmembrane component; iron-siderophore uptake system ATP-binding protein 7778702 fepC 1216841 fepC Streptomyces avermitilis MA-4680 iron-siderophore uptake system ATP-binding protein NP_827669.1 7777815 D 227882 CDS NP_827670.1 29833036 1216842 complement(7778912..7779259) 1 NC_003155.4 hypothetical protein 7779259 1216842 SAV_6494 Streptomyces avermitilis MA-4680 hypothetical protein NP_827670.1 7778912 R 227882 CDS NP_827671.1 29833037 1216843 7779302..7779607 1 NC_003155.4 hypothetical protein 7779607 1216843 SAV_6495 Streptomyces avermitilis MA-4680 hypothetical protein NP_827671.1 7779302 D 227882 CDS NP_827672.1 29833038 1216844 7779615..7780430 1 NC_003155.4 PF01479: S4 domain, PF01728: FtsJ-like methyltransferase; rRNA methylase 7780430 1216844 SAV_6496 Streptomyces avermitilis MA-4680 rRNA methylase NP_827672.1 7779615 D 227882 CDS NP_827673.1 29833039 1216845 7780427..7781332 1 NC_003155.4 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 7781332 ppnK 1216845 ppnK Streptomyces avermitilis MA-4680 inorganic polyphosphate/ATP-NAD kinase NP_827673.1 7780427 D 227882 CDS NP_827674.1 29833040 1216846 complement(7781421..7782944) 1 NC_003155.4 PF02687: Predicted permease; hypothetical protein 7782944 1216846 SAV_6498 Streptomyces avermitilis MA-4680 hypothetical protein NP_827674.1 7781421 R 227882 CDS NP_827675.1 29833041 1211498 7782993..7784729 1 NC_003155.4 PF02483: SMC family, C-terminal domain; DNA recombination and repair protein 7784729 recN 1211498 recN Streptomyces avermitilis MA-4680 DNA recombination and repair protein NP_827675.1 7782993 D 227882 CDS NP_827676.1 29833042 1216847 7784805..7785704 1 NC_003155.4 hypothetical protein 7785704 1216847 SAV_6500 Streptomyces avermitilis MA-4680 hypothetical protein NP_827676.1 7784805 D 227882 CDS NP_827677.1 29833043 1216848 7785976..7787148 1 NC_003155.4 PF00534: Glycosyl transferases group 1; glycosyl transferase 7787148 1216848 SAV_6501 Streptomyces avermitilis MA-4680 glycosyl transferase NP_827677.1 7785976 D 227882 CDS NP_827678.1 29833044 1216849 complement(7787170..7788819) 1 NC_003155.4 regulatory protein 7788819 1216849 SAV_6502 Streptomyces avermitilis MA-4680 regulatory protein NP_827678.1 7787170 R 227882 CDS NP_827679.1 29833045 1216850 complement(7788896..7790722) 1 NC_003155.4 PF00723: Glycosyl hydrolases family 15; glycosyl hydrolase 7790722 1216850 SAV_6503 Streptomyces avermitilis MA-4680 glycosyl hydrolase NP_827679.1 7788896 R 227882 CDS NP_827680.1 29833046 1211499 7791198..7792847 1 NC_003155.4 CTP synthase; CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 7792847 pyrG 1211499 pyrG Streptomyces avermitilis MA-4680 CTP synthetase NP_827680.1 7791198 D 227882 CDS NP_827681.1 29833047 1211500 7792863..7793558 1 NC_003155.4 ADP-ribose pyrophosphatase 7793558 nudF 1211500 nudF Streptomyces avermitilis MA-4680 ADP-ribose pyrophosphatase NP_827681.1 7792863 D 227882 CDS NP_827682.1 29833048 1216851 7793719..7795800 1 NC_003155.4 regulatory protein 7795800 1216851 SAV_6506 Streptomyces avermitilis MA-4680 regulatory protein NP_827682.1 7793719 D 227882 CDS NP_827683.1 29833049 1211501 7795945..7797060 1 NC_003155.4 L-alanine dehydrogenase 7797060 ald 1211501 ald Streptomyces avermitilis MA-4680 L-alanine dehydrogenase NP_827683.1 7795945 D 227882 CDS NP_827684.1 29833050 1216852 7797591..7798631 1 NC_003155.4 PF01656: CobQ/CobB/MinD/ParA nucleotide binding domain; partitioning or sporulation protein 7798631 parA2 1216852 parA2 Streptomyces avermitilis MA-4680 partitioning or sporulation protein NP_827684.1 7797591 D 227882 CDS NP_827685.1 29833051 1216853 7798616..7799200 1 NC_003155.4 hypothetical protein 7799200 1216853 SAV_6509 Streptomyces avermitilis MA-4680 hypothetical protein NP_827685.1 7798616 D 227882 CDS NP_827686.1 29833052 1216854 7799763..7800554 1 NC_003155.4 PF02616: Uncharacterised ACR, COG1354; hypothetical protein 7800554 1216854 SAV_6510 Streptomyces avermitilis MA-4680 hypothetical protein NP_827686.1 7799763 D 227882 CDS NP_827687.1 29833053 1216855 7800551..7801201 1 NC_003155.4 transcriptional regulator 7801201 1216855 SAV_6511 Streptomyces avermitilis MA-4680 transcriptional regulator NP_827687.1 7800551 D 227882 CDS NP_827688.1 29833054 1216856 7801201..7802271 1 NC_003155.4 pseudouridine synthase 7802271 rluB 1216856 rluB Streptomyces avermitilis MA-4680 pseudouridine synthase NP_827688.1 7801201 D 227882 CDS NP_827689.1 29833055 1216857 7802441..7803202 1 NC_003155.4 PF00293: NUDIX domain; DNA hydrolase 7803202 1216857 SAV_6513 Streptomyces avermitilis MA-4680 DNA hydrolase NP_827689.1 7802441 D 227882 CDS NP_827690.1 29833056 1211502 7803202..7804224 1 NC_003155.4 ADP-ribosylglycohydrolase 7804224 draG2 1211502 draG2 Streptomyces avermitilis MA-4680 ADP-ribosylglycohydrolase NP_827690.1 7803202 D 227882 CDS NP_827691.1 29833057 1216858 7804228..7804977 1 NC_003155.4 hypothetical protein 7804977 1216858 SAV_6515 Streptomyces avermitilis MA-4680 hypothetical protein NP_827691.1 7804228 D 227882 CDS NP_827692.1 29833058 1216859 complement(7804903..7805664) 1 NC_003155.4 hypothetical protein 7805664 1216859 SAV_6516 Streptomyces avermitilis MA-4680 hypothetical protein NP_827692.1 7804903 R 227882 CDS NP_827693.1 29833059 1216860 complement(7805686..7806150) 1 NC_003155.4 iron sulphur protein 7806150 1216860 SAV_6517 Streptomyces avermitilis MA-4680 iron sulphur protein NP_827693.1 7805686 R 227882 CDS NP_827694.1 29833060 1216861 complement(7806147..7806731) 1 NC_003155.4 hypothetical protein 7806731 1216861 SAV_6518 Streptomyces avermitilis MA-4680 hypothetical protein NP_827694.1 7806147 R 227882 CDS NP_827695.1 29833061 1216862 complement(7806770..7807465) 1 NC_003155.4 hypothetical protein 7807465 1216862 SAV_6519 Streptomyces avermitilis MA-4680 hypothetical protein NP_827695.1 7806770 R 227882 CDS NP_827696.1 29833062 1211503 7807676..7808038 1 NC_003155.4 EC:5.4.99.5; chorismate mutase 7808038 aroH1 1211503 aroH1 Streptomyces avermitilis MA-4680 chorismate mutase NP_827696.1 7807676 D 227882 CDS NP_827697.1 29833063 1211504 7808035..7809129 1 NC_003155.4 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase 7809129 tyrA 1211504 tyrA Streptomyces avermitilis MA-4680 prephenate dehydrogenase NP_827697.1 7808035 D 227882 CDS NP_827698.1 29833064 1211505 7809255..7809950 1 NC_003155.4 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 7809950 cmk 1211505 cmk Streptomyces avermitilis MA-4680 cytidylate kinase NP_827698.1 7809255 D 227882 CDS NP_827699.1 29833065 1216863 7809908..7810624 1 NC_003155.4 1-acylglycerol-3-phosphate O-acyltransferase 7810624 plsC7 1216863 plsC7 Streptomyces avermitilis MA-4680 1-acylglycerol-3-phosphate O-acyltransferase NP_827699.1 7809908 D 227882 CDS NP_827700.1 29833066 1216864 7810703..7812178 1 NC_003155.4 synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 7812178 engA 1216864 engA Streptomyces avermitilis MA-4680 GTP-binding protein EngA NP_827700.1 7810703 D 227882 CDS NP_827701.1 29833067 1216865 complement(7812249..7812638) 1 NC_003155.4 hypothetical protein 7812638 1216865 SAV_6525 Streptomyces avermitilis MA-4680 hypothetical protein NP_827701.1 7812249 R 227882 CDS NP_827702.1 29833068 1216866 complement(7812809..7813636) 1 NC_003155.4 hypothetical protein 7813636 1216866 SAV_6526 Streptomyces avermitilis MA-4680 hypothetical protein NP_827702.1 7812809 R 227882 CDS NP_827703.1 29833069 1216867 7814121..7814795 1 NC_003155.4 PF06737: Transglycosylase-like domain; peptidoglycan-binding protein 7814795 1216867 SAV_6527 Streptomyces avermitilis MA-4680 peptidoglycan-binding protein NP_827703.1 7814121 D 227882 CDS NP_827704.1 29833070 1216868 7814934..7815524 1 NC_003155.4 PF06737: Transglycosylase-like domain; peptidoglycan-binding protein 7815524 1216868 SAV_6528 Streptomyces avermitilis MA-4680 peptidoglycan-binding protein NP_827704.1 7814934 D 227882 CDS NP_827705.1 29833071 1216869 complement(7815603..7816253) 1 NC_003155.4 ABC transporter ATP-binding protein 7816253 1216869 SAV_6529 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_827705.1 7815603 R 227882 CDS NP_827706.1 29833072 1216870 complement(7816250..7817059) 1 NC_003155.4 ABC transporter ATP-binding protein 7817059 1216870 SAV_6530 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_827706.1 7816250 R 227882 CDS YP_187529.1 57833866 3238946 complement(7817291..7819186) 1 NC_003155.4 ABC transporter permease 7819186 3238946 SAV_7582 Streptomyces avermitilis MA-4680 ABC transporter permease YP_187529.1 7817291 R 227882 CDS NP_827707.1 29833073 1216871 complement(7819186..7819668) 1 NC_003155.4 hypothetical protein 7819668 1216871 SAV_6531 Streptomyces avermitilis MA-4680 hypothetical protein NP_827707.1 7819186 R 227882 CDS NP_827708.1 29833074 1216872 7819821..7820390 1 NC_003155.4 hypothetical protein 7820390 1216872 SAV_6532 Streptomyces avermitilis MA-4680 hypothetical protein NP_827708.1 7819821 D 227882 CDS NP_827709.1 29833075 1216873 7820359..7821648 1 NC_003155.4 hypothetical protein 7821648 1216873 SAV_6533 Streptomyces avermitilis MA-4680 hypothetical protein NP_827709.1 7820359 D 227882 CDS NP_827710.1 29833076 1216874 7821802..7823064 1 NC_003155.4 PF00534: Glycosyl transferases group 1; transferase 7823064 1216874 SAV_6534 Streptomyces avermitilis MA-4680 transferase NP_827710.1 7821802 D 227882 CDS NP_827711.1 29833077 1216875 7823061..7823897 1 NC_003155.4 hypothetical protein 7823897 1216875 SAV_6535 Streptomyces avermitilis MA-4680 hypothetical protein NP_827711.1 7823061 D 227882 CDS NP_827712.1 29833078 1216876 7823967..7825001 1 NC_003155.4 DeoR family transcriptional regulator 7825001 1216876 SAV_6536 Streptomyces avermitilis MA-4680 DeoR family transcriptional regulator NP_827712.1 7823967 D 227882 CDS NP_827713.1 29833079 1216877 complement(7824883..7826574) 1 NC_003155.4 EC 1.9.3.1; cytochrome c oxidase subunit I 7826574 ctaD2 1216877 ctaD2 Streptomyces avermitilis MA-4680 cytochrome c oxidase subunit I NP_827713.1 7824883 R 227882 CDS NP_827714.1 29833080 1216878 7827008..7827223 1 NC_003155.4 hypothetical protein 7827223 1216878 SAV_6538 Streptomyces avermitilis MA-4680 hypothetical protein NP_827714.1 7827008 D 227882 CDS NP_827715.1 29833081 1216879 complement(7827346..7828362) 1 NC_003155.4 PF01569: PAP2 superfamily; integral membrane protein 7828362 1216879 SAV_6539 Streptomyces avermitilis MA-4680 integral membrane protein NP_827715.1 7827346 R 227882 CDS NP_827716.1 29833082 1216880 complement(7828601..7829767) 1 NC_003155.4 PF04188: Protein of unknown function (DUF409); integral membrane protein 7829767 1216880 SAV_6540 Streptomyces avermitilis MA-4680 integral membrane protein NP_827716.1 7828601 R 227882 CDS NP_827717.1 29833083 1216881 7830029..7831636 1 NC_003155.4 PF07690: Major Facilitator Superfamily; multidrug efflux protein 7831636 1216881 SAV_6541 Streptomyces avermitilis MA-4680 multidrug efflux protein NP_827717.1 7830029 D 227882 CDS NP_827718.1 29833084 1211506 7831763..7832938 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 7832938 fadE12 1211506 fadE12 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_827718.1 7831763 D 227882 CDS NP_827719.1 29833085 1216882 complement(7832972..7833409) 1 NC_003155.4 PF04472: Protein of unknown function (DUF552); hypothetical protein 7833409 1216882 SAV_6543 Streptomyces avermitilis MA-4680 hypothetical protein NP_827719.1 7832972 R 227882 CDS NP_827720.1 29833086 1216883 7833762..7834910 1 NC_003155.4 regulatory protein 7834910 1216883 SAV_6544 Streptomyces avermitilis MA-4680 regulatory protein NP_827720.1 7833762 D 227882 CDS NP_827721.1 29833087 1216884 complement(7834999..7835955) 1 NC_003155.4 ABC transporter substrate-binding protein 7835955 1216884 SAV_6545 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_827721.1 7834999 R 227882 CDS NP_827722.1 29833088 1216885 7836397..7837242 1 NC_003155.4 ABC transporter permease 7837242 1216885 SAV_6546 Streptomyces avermitilis MA-4680 ABC transporter permease NP_827722.1 7836397 D 227882 CDS NP_827723.1 29833089 1216886 7837239..7838999 1 NC_003155.4 hypothetical protein 7838999 1216886 SAV_6547 Streptomyces avermitilis MA-4680 hypothetical protein NP_827723.1 7837239 D 227882 CDS NP_827724.1 29833090 1216887 7838996..7839784 1 NC_003155.4 ABC transporter ATP-binding protein 7839784 1216887 SAV_6548 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_827724.1 7838996 D 227882 CDS NP_827725.1 29833091 1216888 7839800..7840918 1 NC_003155.4 FMNH2-utilizing oxygenase 7840918 1216888 SAV_6549 Streptomyces avermitilis MA-4680 FMNH2-utilizing oxygenase NP_827725.1 7839800 D 227882 CDS NP_827726.1 29833092 1216889 7840915..7842300 1 NC_003155.4 FMNH2-utilizing oxygenase 7842300 1216889 SAV_6550 Streptomyces avermitilis MA-4680 FMNH2-utilizing oxygenase NP_827726.1 7840915 D 227882 CDS NP_827727.1 29833093 1216890 7842553..7842825 1 NC_003155.4 hypothetical protein 7842825 1216890 SAV_6551 Streptomyces avermitilis MA-4680 hypothetical protein NP_827727.1 7842553 D 227882 CDS NP_827728.1 29833094 1211507 7842932..7844029 1 NC_003155.4 PF02983: Alpha-lytic protease prodomain; serine protease precursor 7844029 sprA 1211507 sprA Streptomyces avermitilis MA-4680 serine protease precursor NP_827728.1 7842932 D 227882 CDS NP_827729.1 29833095 1211508 7844448..7845614 1 NC_003155.4 PF02983: Alpha-lytic protease prodomain; serine protease precursor 7845614 sprB 1211508 sprB Streptomyces avermitilis MA-4680 serine protease precursor NP_827729.1 7844448 D 227882 CDS NP_827730.1 29833096 1216891 7846297..7846827 1 NC_003155.4 hypothetical protein 7846827 1216891 SAV_6554 Streptomyces avermitilis MA-4680 hypothetical protein NP_827730.1 7846297 D 227882 CDS NP_827731.1 29833097 1211509 7847040..7850525 1 NC_003155.4 DNA polymerase III alpha subunit 7850525 dnaE2 1211509 dnaE2 Streptomyces avermitilis MA-4680 DNA polymerase III alpha subunit NP_827731.1 7847040 D 227882 CDS NP_827732.1 29833098 1216892 7850522..7851496 1 NC_003155.4 PF00817: impB/mucB/samB family; hypothetical protein 7851496 1216892 SAV_6556 Streptomyces avermitilis MA-4680 hypothetical protein NP_827732.1 7850522 D 227882 CDS NP_827733.1 29833099 1216893 complement(7851525..7851911) 1 NC_003155.4 PF00190: Cupin; hypothetical protein 7851911 1216893 SAV_6557 Streptomyces avermitilis MA-4680 hypothetical protein NP_827733.1 7851525 R 227882 CDS NP_827734.1 29833100 1216894 7851982..7852428 1 NC_003155.4 MarR family transcriptional regulator 7852428 1216894 SAV_6558 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_827734.1 7851982 D 227882 CDS NP_827735.1 29833101 1216895 7852591..7853451 1 NC_003155.4 lipase 7853451 lpsA2 1216895 lpsA2 Streptomyces avermitilis MA-4680 lipase NP_827735.1 7852591 D 227882 CDS NP_827736.1 29833102 1216896 complement(7853539..7854570) 1 NC_003155.4 cellulose-binding protein 7854570 1216896 SAV_6560 Streptomyces avermitilis MA-4680 cellulose-binding protein NP_827736.1 7853539 R 227882 CDS NP_827737.1 29833103 1216897 7854729..7855199 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 7855199 1216897 SAV_6561 Streptomyces avermitilis MA-4680 acetyltransferase NP_827737.1 7854729 D 227882 CDS NP_827738.1 29833104 1216898 complement(7855241..7855414) 1 NC_003155.4 hypothetical protein 7855414 1216898 SAV_6562 Streptomyces avermitilis MA-4680 hypothetical protein NP_827738.1 7855241 R 227882 CDS NP_827739.1 29833105 1216899 7855489..7856136 1 NC_003155.4 PF01209: ubiE/COQ5 methyltransferase family; hypothetical protein 7856136 1216899 SAV_6563 Streptomyces avermitilis MA-4680 hypothetical protein NP_827739.1 7855489 D 227882 CDS NP_827740.1 29833106 1216900 complement(7856147..7856665) 1 NC_003155.4 PF04167: Protein of unknown function (DUF402); hypothetical protein 7856665 1216900 SAV_6564 Streptomyces avermitilis MA-4680 hypothetical protein NP_827740.1 7856147 R 227882 CDS NP_827741.1 29833107 1216901 complement(7856628..7857656) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 7857656 1216901 SAV_6566 Streptomyces avermitilis MA-4680 acetyltransferase NP_827741.1 7856628 R 227882 CDS NP_827742.1 29833108 1216902 7857642..7858028 1 NC_003155.4 GntR family transcriptional regulator 7858028 1216902 SAV_6565 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_827742.1 7857642 D 227882 CDS NP_827743.1 29833109 1216903 complement(7858065..7858829) 1 NC_003155.4 PF01904: Protein of unknown function DUF72; hypothetical protein 7858829 1216903 SAV_6567 Streptomyces avermitilis MA-4680 hypothetical protein NP_827743.1 7858065 R 227882 CDS NP_827744.1 29833110 1216904 complement(7858866..7859960) 1 NC_003155.4 PF00004: ATPase family associated with various cellular activities (AAA); ATPase 7859960 1216904 SAV_6568 Streptomyces avermitilis MA-4680 ATPase NP_827744.1 7858866 R 227882 CDS NP_827745.1 29833111 1211510 7860303..7861568 1 NC_003155.4 xylan 1,4-beta-xylosidase 7861568 xynB3 1211510 xynB3 Streptomyces avermitilis MA-4680 xylan 1,4-beta-xylosidase NP_827745.1 7860303 D 227882 CDS NP_827746.1 29833112 1216905 complement(7861637..7865329) 1 NC_003155.4 PF01554: MatE; hypothetical protein 7865329 1216905 SAV_6570 Streptomyces avermitilis MA-4680 hypothetical protein NP_827746.1 7861637 R 227882 CDS NP_827747.1 29833113 1216906 complement(7865463..7866263) 1 NC_003155.4 PF01522: Polysaccharide deacetylase; polysaccharide deacetylase 7866263 1216906 SAV_6571 Streptomyces avermitilis MA-4680 polysaccharide deacetylase NP_827747.1 7865463 R 227882 CDS NP_827748.1 29833114 1211511 complement(7866260..7867231) 1 NC_003155.4 succinoglycan biosynthesis protein 7867231 exoM 1211511 exoM Streptomyces avermitilis MA-4680 succinoglycan biosynthesis protein NP_827748.1 7866260 R 227882 CDS NP_827749.1 29833115 1216907 complement(7867252..7868070) 1 NC_003155.4 glycosyltransferase 7868070 1216907 SAV_6573 Streptomyces avermitilis MA-4680 glycosyltransferase NP_827749.1 7867252 R 227882 CDS NP_827750.1 29833116 1216908 complement(7868446..7869540) 1 NC_003155.4 hypothetical protein 7869540 1216908 SAV_6574 Streptomyces avermitilis MA-4680 hypothetical protein NP_827750.1 7868446 R 227882 CDS NP_827751.1 29833117 1216909 complement(7869545..7870036) 1 NC_003155.4 hypothetical protein 7870036 1216909 SAV_6575 Streptomyces avermitilis MA-4680 hypothetical protein NP_827751.1 7869545 R 227882 CDS NP_827752.1 29833118 1216910 complement(7870143..7871234) 1 NC_003155.4 PF00082: Subtilase family; alkaline serine protease 7871234 aprA 1216910 aprA Streptomyces avermitilis MA-4680 alkaline serine protease NP_827752.1 7870143 R 227882 CDS NP_827753.1 29833119 1216911 7871666..7872475 1 NC_003155.4 PF00657: GDSL-like Lipase/Acylhydrolase; hydrolase 7872475 1216911 SAV_6577 Streptomyces avermitilis MA-4680 hydrolase NP_827753.1 7871666 D 227882 CDS NP_827754.1 29833120 1211512 complement(7872510..7874162) 1 NC_003155.4 serine/threonine protein kinase 7874162 pkn29 1211512 pkn29 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_827754.1 7872510 R 227882 CDS NP_827755.1 29833121 1216912 complement(7874190..7875914) 1 NC_003155.4 PF03824: High-affinity nickel-transport protein; hypothetical protein 7875914 1216912 SAV_6579 Streptomyces avermitilis MA-4680 hypothetical protein NP_827755.1 7874190 R 227882 CDS NP_827756.1 29833122 1216913 complement(7875911..7877923) 1 NC_003155.4 PF00515: TPR Domain; hypothetical protein 7877923 1216913 SAV_6580 Streptomyces avermitilis MA-4680 hypothetical protein NP_827756.1 7875911 R 227882 CDS NP_827757.1 29833123 1216914 complement(7877971..7879491) 1 NC_003155.4 hypothetical protein 7879491 1216914 SAV_6581 Streptomyces avermitilis MA-4680 hypothetical protein NP_827757.1 7877971 R 227882 CDS NP_827758.1 29833124 1211513 7879724..7880272 1 NC_003155.4 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. bovis this protein has been shown to be involved in expression of antigenic proteins; RNA polymerase sigma factor SigK 7880272 sig53 1211513 sig53 Streptomyces avermitilis MA-4680 RNA polymerase sigma factor SigK NP_827758.1 7879724 D 227882 CDS NP_827759.1 29833125 1216915 7880269..7881084 1 NC_003155.4 hypothetical protein 7881084 1216915 SAV_6583 Streptomyces avermitilis MA-4680 hypothetical protein NP_827759.1 7880269 D 227882 CDS NP_827760.1 29833126 1216916 7881200..7881469 1 NC_003155.4 hypothetical protein 7881469 1216916 SAV_6584 Streptomyces avermitilis MA-4680 hypothetical protein NP_827760.1 7881200 D 227882 CDS NP_827761.1 29833127 1216917 complement(7881657..7882844) 1 NC_003155.4 hypothetical protein 7882844 1216917 SAV_6585 Streptomyces avermitilis MA-4680 hypothetical protein NP_827761.1 7881657 R 227882 CDS NP_827762.1 29833128 1216918 complement(7882893..7883642) 1 NC_003155.4 PF07702: UbiC transcription regulator-associated; GntR family transcriptional regulator 7883642 1216918 SAV_6586 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_827762.1 7882893 R 227882 CDS NP_827763.1 29833129 1211514 complement(7883693..7885009) 1 NC_003155.4 An oxygenase that acts to open the ring of homogentisate formingmaleylacetoacetate as part of the catabolism of L-tyrosine and L-phenylalanine; homogentisate 1,2-dioxygenase 7885009 hmgA 1211514 hmgA Streptomyces avermitilis MA-4680 homogentisate 1,2-dioxygenase NP_827763.1 7883693 R 227882 CDS NP_827764.1 29833130 1216919 7885176..7885841 1 NC_003155.4 protein 7885841 1216919 SAV_6588 Streptomyces avermitilis MA-4680 protein NP_827764.1 7885176 D 227882 CDS NP_827765.1 29833131 1216920 7885838..7886458 1 NC_003155.4 TetR family transcriptional regulator 7886458 1216920 SAV_6589 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_827765.1 7885838 D 227882 CDS NP_827766.1 29833132 1216921 7886648..7888879 1 NC_003155.4 PF00384: Molybdopterin oxidoreductase; dehydrogenase 7888879 1216921 SAV_6590 Streptomyces avermitilis MA-4680 dehydrogenase NP_827766.1 7886648 D 227882 CDS NP_827767.1 29833133 1211515 7889002..7890408 1 NC_003155.4 PF03600: Citrate transporter; divalent metal ions/citrate complex secondary transporter 7890408 citH 1211515 citH Streptomyces avermitilis MA-4680 divalent metal ions/citrate complex secondary transporter NP_827767.1 7889002 D 227882 CDS NP_827768.1 29833134 1216922 7890498..7891658 1 NC_003155.4 PF07690: Major Facilitator Superfamily; integral membrane transport protein 7891658 1216922 SAV_6592 Streptomyces avermitilis MA-4680 integral membrane transport protein NP_827768.1 7890498 D 227882 CDS NP_827769.1 29833135 1216923 7891762..7892523 1 NC_003155.4 hypothetical protein 7892523 1216923 SAV_6593 Streptomyces avermitilis MA-4680 hypothetical protein NP_827769.1 7891762 D 227882 CDS NP_827770.1 29833136 1216924 7892510..7893241 1 NC_003155.4 PF04203: Sortase family; hypothetical protein 7893241 1216924 SAV_6594 Streptomyces avermitilis MA-4680 hypothetical protein NP_827770.1 7892510 D 227882 CDS NP_827771.1 29833137 1216925 7893453..7894841 1 NC_003155.4 PF00171: Aldehyde dehydrogenase family; aldehyde dehydrogenase 7894841 1216925 SAV_6595 Streptomyces avermitilis MA-4680 aldehyde dehydrogenase NP_827771.1 7893453 D 227882 CDS NP_827772.1 29833138 1216926 7894856..7895935 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; alcohol dehydrogenase 7895935 adhA9 1216926 adhA9 Streptomyces avermitilis MA-4680 alcohol dehydrogenase NP_827772.1 7894856 D 227882 CDS NP_827773.1 29833139 1216927 complement(7895942..7896952) 1 NC_003155.4 PF00892: Integral membrane protein DUF6; hypothetical protein 7896952 1216927 SAV_6597 Streptomyces avermitilis MA-4680 hypothetical protein NP_827773.1 7895942 R 227882 CDS NP_827774.1 29833140 1216928 complement(7897104..7897859) 1 NC_003155.4 transcription regulator ArsR 7897859 1216928 SAV_6598 Streptomyces avermitilis MA-4680 transcription regulator ArsR NP_827774.1 7897104 R 227882 CDS NP_827775.1 29833141 1216929 complement(7897953..7898594) 1 NC_003155.4 TetR family transcriptional regulator 7898594 1216929 SAV_6599 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_827775.1 7897953 R 227882 CDS NP_827776.1 29833142 1211516 7898672..7899823 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 7899823 fadE3 1211516 fadE3 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_827776.1 7898672 D 227882 CDS NP_827777.1 29833143 1216930 7899898..7900188 1 NC_003155.4 hypothetical protein 7900188 1216930 SAV_6601 Streptomyces avermitilis MA-4680 hypothetical protein NP_827777.1 7899898 D 227882 CDS NP_827778.1 29833144 1216931 7900310..7900939 1 NC_003155.4 TetR family transcriptional regulator 7900939 1216931 SAV_6602 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_827778.1 7900310 D 227882 CDS NP_827779.1 29833145 1216932 complement(7900986..7901447) 1 NC_003155.4 PF01575: MaoC like domain; hypothetical protein 7901447 1216932 SAV_6603 Streptomyces avermitilis MA-4680 hypothetical protein NP_827779.1 7900986 R 227882 CDS NP_827780.1 29833146 1216933 7901555..7902064 1 NC_003155.4 MerR family transcriptional regulator 7902064 1216933 SAV_6604 Streptomyces avermitilis MA-4680 MerR family transcriptional regulator NP_827780.1 7901555 D 227882 CDS NP_827781.1 29833147 1216934 complement(7902105..7903172) 1 NC_003155.4 PF01588: Putative tRNA binding domain; hypothetical protein 7903172 1216934 SAV_6605 Streptomyces avermitilis MA-4680 hypothetical protein NP_827781.1 7902105 R 227882 CDS NP_827782.1 29833148 1216935 7903707..7904228 1 NC_003155.4 hypothetical protein 7904228 1216935 SAV_6606 Streptomyces avermitilis MA-4680 hypothetical protein NP_827782.1 7903707 D 227882 CDS NP_827783.1 29833149 1216936 complement(7904314..7904916) 1 NC_003155.4 hypothetical protein 7904916 1216936 SAV_6607 Streptomyces avermitilis MA-4680 hypothetical protein NP_827783.1 7904314 R 227882 CDS NP_827784.1 29833150 1216937 7905201..7907990 1 NC_003155.4 PF01804: Penicillin amidase; penicillin acylase 7907990 pacB3 1216937 pacB3 Streptomyces avermitilis MA-4680 penicillin acylase NP_827784.1 7905201 D 227882 CDS NP_827785.1 29833151 1216938 complement(7908027..7909388) 1 NC_003155.4 PF05990: Protein of unknown function (DUF900); hypothetical protein 7909388 1216938 SAV_6609 Streptomyces avermitilis MA-4680 hypothetical protein NP_827785.1 7908027 R 227882 CDS NP_827786.1 29833152 1216939 complement(7909514..7910833) 1 NC_003155.4 PF07075: Protein of unknown function (DUF1343); hypothetical protein 7910833 1216939 SAV_6610 Streptomyces avermitilis MA-4680 hypothetical protein NP_827786.1 7909514 R 227882 CDS NP_827787.1 29833153 1216940 7910967..7911731 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 7911731 1216940 SAV_6611 Streptomyces avermitilis MA-4680 dehydrogenase NP_827787.1 7910967 D 227882 CDS NP_827788.1 29833154 1211517 7911728..7913395 1 NC_003155.4 PF00501: AMP-binding enzyme; acyl-CoA synthetase, long chain-fatty acid:CoA ligase 7913395 fadD15 1211517 fadD15 Streptomyces avermitilis MA-4680 acyl-CoA synthetase, long chain-fatty acid:CoA ligase NP_827788.1 7911728 D 227882 CDS NP_827789.1 29833155 1216941 7913414..7914016 1 NC_003155.4 TetR family transcriptional regulator 7914016 1216941 SAV_6613 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_827789.1 7913414 D 227882 CDS NP_827790.1 29833156 1211518 complement(7914103..7915326) 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 7915326 fadE17 1211518 fadE17 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_827790.1 7914103 R 227882 CDS NP_827791.1 29833157 1216942 complement(7915333..7916355) 1 NC_003155.4 phosphotransferase 7916355 1216942 SAV_6615 Streptomyces avermitilis MA-4680 phosphotransferase NP_827791.1 7915333 R 227882 CDS NP_827792.1 29833158 1216943 complement(7916537..7917448) 1 NC_003155.4 similar to actIV cyclase; polyketide cyclase 7917448 1216943 SAV_6616 Streptomyces avermitilis MA-4680 polyketide cyclase NP_827792.1 7916537 R 227882 CDS NP_827793.1 29833159 1216944 complement(7917633..7917956) 1 NC_003155.4 hypothetical protein 7917956 1216944 SAV_6617 Streptomyces avermitilis MA-4680 hypothetical protein NP_827793.1 7917633 R 227882 CDS NP_827794.1 29833160 1216945 complement(7917953..7918345) 1 NC_003155.4 PF02656: Domain of unknown function DUF; hypothetical protein 7918345 1216945 SAV_6618 Streptomyces avermitilis MA-4680 hypothetical protein NP_827794.1 7917953 R 227882 CDS NP_827795.1 29833161 1216946 complement(7918444..7919046) 1 NC_003155.4 PF00293: NUDIX domain; NTP pyrophosphohydrolase 7919046 1216946 SAV_6619 Streptomyces avermitilis MA-4680 NTP pyrophosphohydrolase NP_827795.1 7918444 R 227882 CDS NP_827796.1 29833162 1216947 complement(7919083..7920006) 1 NC_003155.4 PF05653: Protein of unknown function (DUF803); integral membrane protein 7920006 1216947 SAV_6620 Streptomyces avermitilis MA-4680 integral membrane protein NP_827796.1 7919083 R 227882 CDS NP_827797.1 29833163 1216948 7920188..7921843 1 NC_003155.4 proposed role in polysaccahride synthesis; putative FAD-binding dehydrogenase 7921843 1216948 SAV_6621 Streptomyces avermitilis MA-4680 putative FAD-binding dehydrogenase NP_827797.1 7920188 D 227882 CDS NP_827798.1 29833164 1216949 7922313..7923263 1 NC_003155.4 hypothetical protein 7923263 1216949 SAV_6622 Streptomyces avermitilis MA-4680 hypothetical protein NP_827798.1 7922313 D 227882 CDS NP_827799.1 29833165 1216950 7923378..7924940 1 NC_003155.4 PF00324: Amino acid permease; amino acid permease 7924940 1216950 SAV_6623 Streptomyces avermitilis MA-4680 amino acid permease NP_827799.1 7923378 D 227882 CDS NP_827800.1 29833166 1216951 7925239..7925850 1 NC_003155.4 PF00174: Oxidoreductase molybdopterin binding domain; hypothetical protein 7925850 1216951 SAV_6624 Streptomyces avermitilis MA-4680 hypothetical protein NP_827800.1 7925239 D 227882 CDS NP_827801.1 29833167 1216952 7925834..7926490 1 NC_003155.4 hypothetical protein 7926490 1216952 SAV_6625 Streptomyces avermitilis MA-4680 hypothetical protein NP_827801.1 7925834 D 227882 CDS NP_827802.1 29833168 1216953 complement(7926763..7927788) 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; L-idonate 5-dehydrogenase 7927788 idnD 1216953 idnD Streptomyces avermitilis MA-4680 L-idonate 5-dehydrogenase NP_827802.1 7926763 R 227882 CDS NP_827803.1 29833169 1211519 complement(7927801..7928559) 1 NC_003155.4 5-keto-D-gluconate 5-reductase 7928559 kduD 1211519 kduD Streptomyces avermitilis MA-4680 5-keto-D-gluconate 5-reductase NP_827803.1 7927801 R 227882 CDS NP_827804.1 29833170 1211520 complement(7928570..7929967) 1 NC_003155.4 gluconate permease 7929967 gntP 1211520 gntP Streptomyces avermitilis MA-4680 gluconate permease NP_827804.1 7928570 R 227882 CDS NP_827805.1 29833171 1211521 complement(7930069..7930605) 1 NC_003155.4 gluconokinase 7930605 gntK2 1211521 gntK2 Streptomyces avermitilis MA-4680 gluconokinase NP_827805.1 7930069 R 227882 CDS NP_827806.1 29833172 1216954 7930737..7931438 1 NC_003155.4 nrps5 gene cluster; GntR family transcriptional regulator 7931438 1216954 SAV_6630 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_827806.1 7930737 D 227882 CDS NP_827807.1 29833173 1216955 complement(7931450..7931872) 1 NC_003155.4 nrps5 gene cluster, PF02810: SEC-C motif; hypothetical protein 7931872 1216955 SAV_6631 Streptomyces avermitilis MA-4680 hypothetical protein NP_827807.1 7931450 R 227882 CDS NP_827808.1 29833174 1216956 complement(7931869..7933320) 1 NC_003155.4 nrps5 gene cluster, PF01433: Peptidase family M1; metallopeptidase 7933320 1216956 SAV_6632 Streptomyces avermitilis MA-4680 metallopeptidase NP_827808.1 7931869 R 227882 CDS NP_827809.1 29833175 1216957 complement(7933326..7937201) 1 NC_003155.4 nrps5 gene cluster; non-ribosomal peptide synthetase 7937201 nrps5 1216957 nrps5 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_827809.1 7933326 R 227882 CDS NP_827810.1 29833176 1216958 7937738..7939063 1 NC_003155.4 PF01546: Peptidase family M20/M25/M40; hypothetical protein 7939063 1216958 SAV_6634 Streptomyces avermitilis MA-4680 hypothetical protein NP_827810.1 7937738 D 227882 CDS NP_827811.1 29833177 1216959 7939230..7939463 1 NC_003155.4 PF03777: Small domain (DUF320); protein 7939463 1216959 SAV_6635 Streptomyces avermitilis MA-4680 protein NP_827811.1 7939230 D 227882 CDS NP_827812.1 29833178 1216960 7939559..7940470 1 NC_003155.4 PF03777: Small domain (DUF320); protein 7940470 1216960 SAV_6636 Streptomyces avermitilis MA-4680 protein NP_827812.1 7939559 D 227882 CDS NP_827813.1 29833179 1216961 complement(7940576..7940764) 1 NC_003155.4 hypothetical protein 7940764 1216961 SAV_6637 Streptomyces avermitilis MA-4680 hypothetical protein NP_827813.1 7940576 R 227882 CDS NP_827814.1 29833180 1216962 7940812..7941522 1 NC_003155.4 hypothetical protein 7941522 1216962 SAV_6638 Streptomyces avermitilis MA-4680 hypothetical protein NP_827814.1 7940812 D 227882 CDS NP_827815.1 29833181 1216963 complement(7941655..7943859) 1 NC_003155.4 hypothetical protein 7943859 1216963 SAV_6639 Streptomyces avermitilis MA-4680 hypothetical protein NP_827815.1 7941655 R 227882 CDS NP_827816.1 29833182 1216964 complement(7943952..7944935) 1 NC_003155.4 PF00248: Aldo/keto reductase family; oxidoreductase 7944935 1216964 SAV_6640 Streptomyces avermitilis MA-4680 oxidoreductase NP_827816.1 7943952 R 227882 CDS NP_827817.1 29833183 1216965 7945089..7946144 1 NC_003155.4 PF00296: Luciferase-like monooxygenase; FMN-dependent monooxygenase 7946144 1216965 SAV_6641 Streptomyces avermitilis MA-4680 FMN-dependent monooxygenase NP_827817.1 7945089 D 227882 CDS NP_827818.1 29833184 1216966 7946370..7947158 1 NC_003155.4 hypothetical protein 7947158 1216966 SAV_6642 Streptomyces avermitilis MA-4680 hypothetical protein NP_827818.1 7946370 D 227882 CDS NP_827819.1 29833185 1216967 complement(7947346..7948377) 1 NC_003155.4 PF01544: CorA-like Mg2+ transporter protein; metal-transport protein 7948377 corA3 1216967 corA3 Streptomyces avermitilis MA-4680 metal-transport protein NP_827819.1 7947346 R 227882 CDS NP_827820.1 29833186 1216968 7948404..7949126 1 NC_003155.4 PF00300: Phosphoglycerate mutase family; mutase 7949126 1216968 SAV_6644 Streptomyces avermitilis MA-4680 mutase NP_827820.1 7948404 D 227882 CDS NP_827821.1 29833187 1216969 7949237..7949827 1 NC_003155.4 hypothetical protein 7949827 1216969 SAV_6645 Streptomyces avermitilis MA-4680 hypothetical protein NP_827821.1 7949237 D 227882 CDS NP_827822.1 29833188 1216970 7949824..7950609 1 NC_003155.4 hypothetical protein 7950609 1216970 SAV_6646 Streptomyces avermitilis MA-4680 hypothetical protein NP_827822.1 7949824 D 227882 CDS NP_827823.1 29833189 1211523 7950762..7951991 1 NC_003155.4 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 7951991 cysS 1211523 cysS Streptomyces avermitilis MA-4680 cysteinyl-tRNA synthetase NP_827823.1 7950762 D 227882 CDS NP_827824.1 29833190 1216971 complement(7952094..7952777) 1 NC_003155.4 hypothetical protein 7952777 1216971 SAV_6648 Streptomyces avermitilis MA-4680 hypothetical protein NP_827824.1 7952094 R 227882 CDS NP_827825.1 29833191 1216972 complement(7952817..7954775) 1 NC_003155.4 PF00082: Subtilase family; serine protease 7954775 1216972 SAV_6649 Streptomyces avermitilis MA-4680 serine protease NP_827825.1 7952817 R 227882 CDS NP_827826.1 29833192 1216973 complement(7955001..7956005) 1 NC_003155.4 PF05601: Protein of unknown function (DUF774); hypothetical protein 7956005 1216973 SAV_6650 Streptomyces avermitilis MA-4680 hypothetical protein NP_827826.1 7955001 R 227882 CDS NP_827827.1 29833193 1216974 complement(7956343..7957041) 1 NC_003155.4 GntR family transcriptional regulator 7957041 1216974 SAV_6651 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_827827.1 7956343 R 227882 CDS NP_827828.1 29833194 1216975 complement(7957101..7958399) 1 NC_003155.4 PF01979: Amidohydrolase family; N-ethylammeline chlorohydrolase 7958399 1216975 SAV_6652 Streptomyces avermitilis MA-4680 N-ethylammeline chlorohydrolase NP_827828.1 7957101 R 227882 CDS NP_827829.1 29833195 1216976 complement(7958396..7959184) 1 NC_003155.4 uridine phosphorylase 7959184 udp 1216976 udp Streptomyces avermitilis MA-4680 uridine phosphorylase NP_827829.1 7958396 R 227882 CDS NP_827830.1 29833196 1216977 complement(7959181..7960047) 1 NC_003155.4 sugar ABC transporter permease 7960047 1216977 SAV_6654 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_827830.1 7959181 R 227882 CDS NP_827831.1 29833197 1216978 complement(7960047..7961108) 1 NC_003155.4 ABC transporter permease 7961108 1216978 SAV_6655 Streptomyces avermitilis MA-4680 ABC transporter permease NP_827831.1 7960047 R 227882 CDS NP_827832.1 29833198 1216979 complement(7961110..7962639) 1 NC_003155.4 sugar ABC transporter ATP-binding protein 7962639 1216979 SAV_6656 Streptomyces avermitilis MA-4680 sugar ABC transporter ATP-binding protein NP_827832.1 7961110 R 227882 CDS NP_827833.1 29833199 1216980 complement(7962620..7963669) 1 NC_003155.4 PF02608: Basic membrane protein; lipoprotein 7963669 1216980 SAV_6657 Streptomyces avermitilis MA-4680 lipoprotein NP_827833.1 7962620 R 227882 CDS NP_827834.1 29833200 1211524 7963968..7965008 1 NC_003155.4 initiation factor eIF-2B alpha subunit 7965008 eif2 1211524 eif2 Streptomyces avermitilis MA-4680 initiation factor eIF-2B alpha subunit NP_827834.1 7963968 D 227882 CDS NP_827835.1 29833201 1211525 complement(7965093..7965701) 1 NC_003155.4 fuculose-1-phosphate aldolase 7965701 fucA3 1211525 fucA3 Streptomyces avermitilis MA-4680 fuculose-1-phosphate aldolase NP_827835.1 7965093 R 227882 CDS NP_827836.1 29833202 1211526 complement(7965698..7966417) 1 NC_003155.4 PF00702: haloacid dehalogenase-like hydrolase; enolase-phosphatase E-1 7966417 masA 1211526 masA Streptomyces avermitilis MA-4680 enolase-phosphatase E-1 NP_827836.1 7965698 R 227882 CDS NP_827837.1 29833203 1216981 complement(7966414..7967007) 1 NC_003155.4 oxidase 7967007 1216981 SAV_6661 Streptomyces avermitilis MA-4680 oxidase NP_827837.1 7966414 R 227882 CDS NP_827838.1 29833204 1211527 7967526..7968644 1 NC_003155.4 5-methylthioribose kinase 7968644 mtnK 1211527 mtnK Streptomyces avermitilis MA-4680 5-methylthioribose kinase NP_827838.1 7967526 D 227882 CDS NP_827839.1 29833205 1211528 complement(7968734..7970350) 1 NC_003155.4 glycerol-3-phosphate dehydrogenase 7970350 gpd 1211528 gpd Streptomyces avermitilis MA-4680 glycerol-3-phosphate dehydrogenase NP_827839.1 7968734 R 227882 CDS NP_827840.1 29833206 1211529 complement(7970359..7971897) 1 NC_003155.4 glycerol kinase 7971897 glpK1 1211529 glpK1 Streptomyces avermitilis MA-4680 glycerol kinase NP_827840.1 7970359 R 227882 CDS NP_827841.1 29833207 1211530 complement(7972005..7972799) 1 NC_003155.4 glycerol uptake facilitator protein 7972799 glpF1 1211530 glpF1 Streptomyces avermitilis MA-4680 glycerol uptake facilitator protein NP_827841.1 7972005 R 227882 CDS NP_827842.1 29833208 1211531 complement(7973151..7973915) 1 NC_003155.4 glycerol operon regulatory protein 7973915 gylR 1211531 gylR Streptomyces avermitilis MA-4680 glycerol operon regulatory protein NP_827842.1 7973151 R 227882 CDS NP_827843.1 29833209 1211532 7974140..7977712 1 NC_003155.4 5-methyltetrahydrofolate:homocysteine S-methyltransferase 7977712 metH 1211532 metH Streptomyces avermitilis MA-4680 5-methyltetrahydrofolate:homocysteine S-methyltransferase NP_827843.1 7974140 D 227882 CDS NP_827844.1 29833210 1216982 7977877..7978629 1 NC_003155.4 PF00702: haloacid dehalogenase-like hydrolase; hydrolase 7978629 1216982 SAV_6668 Streptomyces avermitilis MA-4680 hydrolase NP_827844.1 7977877 D 227882 CDS NP_827845.1 29833211 1216983 7979050..7980654 1 NC_003155.4 PF00496: Bacterial extracellular solute-binding proteins, family 5 Middle; lipoprotein oligopeptide binding protein 7980654 1216983 SAV_6669 Streptomyces avermitilis MA-4680 lipoprotein oligopeptide binding protein NP_827845.1 7979050 D 227882 CDS NP_827846.1 29833212 1216984 7980740..7982323 1 NC_003155.4 PF00496: Bacterial extracellular solute-binding proteins, family 5 Middle; solute binding transport lipoprotein 7982323 1216984 SAV_6670 Streptomyces avermitilis MA-4680 solute binding transport lipoprotein NP_827846.1 7980740 D 227882 CDS NP_827847.1 29833213 1216985 complement(7982413..7983084) 1 NC_003155.4 two-component system response regulator 7983084 1216985 SAV_6671 Streptomyces avermitilis MA-4680 two-component system response regulator NP_827847.1 7982413 R 227882 CDS NP_827848.1 29833214 1216986 complement(7983101..7983961) 1 NC_003155.4 hypothetical protein 7983961 1216986 SAV_6672 Streptomyces avermitilis MA-4680 hypothetical protein NP_827848.1 7983101 R 227882 CDS NP_827849.1 29833215 1216987 7984950..7986080 1 NC_003155.4 PF02163: Peptidase family M50; peptidase 7986080 1216987 SAV_6673 Streptomyces avermitilis MA-4680 peptidase NP_827849.1 7984950 D 227882 CDS NP_827850.1 29833216 1216988 7986121..7987023 1 NC_003155.4 hypothetical protein 7987023 1216988 SAV_6674 Streptomyces avermitilis MA-4680 hypothetical protein NP_827850.1 7986121 D 227882 CDS NP_827851.1 29833217 1216989 7987213..7987788 1 NC_003155.4 hypothetical protein 7987788 1216989 SAV_6675 Streptomyces avermitilis MA-4680 hypothetical protein NP_827851.1 7987213 D 227882 CDS NP_827852.1 29833218 1211533 complement(7987868..7988173) 1 NC_003155.4 ferredoxin 7988173 fdxG 1211533 fdxG Streptomyces avermitilis MA-4680 ferredoxin NP_827852.1 7987868 R 227882 CDS NP_827853.1 29833219 1216990 7988428..7990194 1 NC_003155.4 PF00004: ATPase family associated with various cellular activities (AAA); ATPase AAA 7990194 1216990 SAV_6677 Streptomyces avermitilis MA-4680 ATPase AAA NP_827853.1 7988428 D 227882 CDS NP_827854.1 29833220 1216991 7990430..7991941 1 NC_003155.4 PF03136: Putative proteasome component; proteasome component 7991941 1216991 SAV_6678 Streptomyces avermitilis MA-4680 proteasome component NP_827854.1 7990430 D 227882 CDS NP_827855.1 29833221 1216992 7992097..7992315 1 NC_003155.4 PF05639: Protein of unknown function (DUF797); hypothetical protein 7992315 1216992 SAV_6679 Streptomyces avermitilis MA-4680 hypothetical protein NP_827855.1 7992097 D 227882 CDS NP_827856.1 29833222 1216993 7992334..7992942 1 NC_003155.4 endonuclease VII 7992942 1216993 SAV_6680 Streptomyces avermitilis MA-4680 endonuclease VII NP_827856.1 7992334 D 227882 CDS NP_827857.1 29833223 1211534 7992894..7993739 1 NC_003155.4 PF00227: Proteasome A-type and B-type; 20S proteasome beta-subunit 7993739 prcB1 1211534 prcB1 Streptomyces avermitilis MA-4680 20S proteasome beta-subunit NP_827857.1 7992894 D 227882 CDS NP_827858.1 29833224 1211535 7993807..7994568 1 NC_003155.4 PF00227: Proteasome A-type and B-type; 20S proteasome alpha-subunit 7994568 prcA 1211535 prcA Streptomyces avermitilis MA-4680 20S proteasome alpha-subunit NP_827858.1 7993807 D 227882 CDS NP_827859.1 29833225 1216994 complement(7994625..7995641) 1 NC_003155.4 LacI family transcriptional regulator 7995641 1216994 SAV_6683 Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_827859.1 7994625 R 227882 CDS NP_827860.1 29833226 1216995 7995763..7997022 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane transport protein 7997022 1216995 SAV_6684 Streptomyces avermitilis MA-4680 transmembrane transport protein NP_827860.1 7995763 D 227882 CDS NP_827861.1 29833227 1216996 7997032..7998393 1 NC_003155.4 PF03136: Putative proteasome component; proteasome component 7998393 1216996 SAV_6685 Streptomyces avermitilis MA-4680 proteasome component NP_827861.1 7997032 D 227882 CDS NP_827862.1 29833228 1211536 7998523..7999527 1 NC_003155.4 FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 7999527 fkbB 1211536 fkbB Streptomyces avermitilis MA-4680 FK-506 binding protein, peptidyl-prolyl cis-trans isomerase NP_827862.1 7998523 D 227882 CDS NP_827863.1 29833229 1211537 7999599..7999973 1 NC_003155.4 FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 7999973 fkbP 1211537 fkbP Streptomyces avermitilis MA-4680 FK-506 binding protein, peptidyl-prolyl cis-trans isomerase NP_827863.1 7999599 D 227882 CDS NP_827864.1 29833230 1216997 8000193..8001170 1 NC_003155.4 hypothetical protein 8001170 1216997 SAV_6688 Streptomyces avermitilis MA-4680 hypothetical protein NP_827864.1 8000193 D 227882 CDS NP_827865.1 29833231 1216998 8001187..8002227 1 NC_003155.4 hypothetical protein 8002227 1216998 SAV_6689 Streptomyces avermitilis MA-4680 hypothetical protein NP_827865.1 8001187 D 227882 CDS NP_827866.1 29833232 1216999 8002224..8002604 1 NC_003155.4 hypothetical protein 8002604 1216999 SAV_6690 Streptomyces avermitilis MA-4680 hypothetical protein NP_827866.1 8002224 D 227882 CDS NP_827867.1 29833233 1217000 8002615..8002809 1 NC_003155.4 hypothetical protein 8002809 1217000 SAV_6691 Streptomyces avermitilis MA-4680 hypothetical protein NP_827867.1 8002615 D 227882 CDS NP_827868.1 29833234 1217001 8003144..8003428 1 NC_003155.4 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein A 8003428 tatA 1217001 tatA Streptomyces avermitilis MA-4680 twin arginine translocase protein A NP_827868.1 8003144 D 227882 CDS NP_827869.1 29833235 1217002 8003476..8004423 1 NC_003155.4 PF00902: Sec-independent protein translocase protein (TatC); integral membrane protein 8004423 tatC 1217002 tatC Streptomyces avermitilis MA-4680 integral membrane protein NP_827869.1 8003476 D 227882 CDS NP_827870.1 29833236 1217003 8004455..8005345 1 NC_003155.4 PF00781: Diacylglycerol kinase catalytic domain (presumed); hypothetical protein 8005345 1217003 SAV_6694 Streptomyces avermitilis MA-4680 hypothetical protein NP_827870.1 8004455 D 227882 CDS NP_827871.1 29833237 1211538 8005431..8008244 1 NC_003155.4 PF00270: DEAD/DEAH box helicase; ATP-dependent RNA helicase 8008244 helY 1211538 helY Streptomyces avermitilis MA-4680 ATP-dependent RNA helicase NP_827871.1 8005431 D 227882 CDS NP_827872.1 29833238 1217004 complement(8008333..8009433) 1 NC_003155.4 PF00296: Luciferase-like monooxygenase; monooxygenase 8009433 1217004 SAV_6696 Streptomyces avermitilis MA-4680 monooxygenase NP_827872.1 8008333 R 227882 CDS NP_827873.1 29833239 1217005 complement(8009625..8011277) 1 NC_003155.4 catalyzes the hydrolysis of allophanate; allophanate hydrolase 8011277 1217005 SAV_6697 Streptomyces avermitilis MA-4680 allophanate hydrolase NP_827873.1 8009625 R 227882 CDS NP_827874.1 29833240 1211539 complement(8011294..8014809) 1 NC_003155.4 urea amidolyase 8014809 uahA 1211539 uahA Streptomyces avermitilis MA-4680 urea amidolyase NP_827874.1 8011294 R 227882 CDS NP_827875.1 29833241 1217006 complement(8014806..8015441) 1 NC_003155.4 hypothetical protein 8015441 1217006 SAV_6699 Streptomyces avermitilis MA-4680 hypothetical protein NP_827875.1 8014806 R 227882 CDS NP_827876.1 29833242 1217007 complement(8015438..8016262) 1 NC_003155.4 hypothetical protein 8016262 1217007 SAV_6700 Streptomyces avermitilis MA-4680 hypothetical protein NP_827876.1 8015438 R 227882 CDS NP_827877.1 29833243 1217008 8016448..8017071 1 NC_003155.4 TetR family transcriptional regulator 8017071 1217008 SAV_6701 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_827877.1 8016448 D 227882 CDS NP_827878.1 29833244 1211540 8017395..8018978 1 NC_003155.4 multi-component regulatory system-10; sensor-like histidine kinase 8018978 cvnA10 1211540 cvnA10 Streptomyces avermitilis MA-4680 sensor-like histidine kinase NP_827878.1 8017395 D 227882 CDS NP_827879.1 29833245 1211541 8018975..8019382 1 NC_003155.4 multi-component regulatory system-10, PF03259: Roadblock/LC7 domain; hypothetical protein 8019382 cvnB10 1211541 cvnB10 Streptomyces avermitilis MA-4680 hypothetical protein NP_827879.1 8018975 D 227882 CDS NP_827880.1 29833246 1211542 8019379..8019804 1 NC_003155.4 multi-component regulatory system-10, PF05331: Protein of unknown function (DUF742); hypothetical protein 8019804 cvnC10 1211542 cvnC10 Streptomyces avermitilis MA-4680 hypothetical protein NP_827880.1 8019379 D 227882 CDS NP_827881.1 29833247 1211543 8019785..8020405 1 NC_003155.4 multi-component regulatory system-10; ATP/GTP-binding protein 8020405 cvnD10 1211543 cvnD10 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_827881.1 8019785 D 227882 CDS NP_827882.1 29833248 1211544 8020473..8021933 1 NC_003155.4 CYP157C2, adjacent to multi-component regulatory system-10; cytochrome P450 8021933 cyp24 1211544 cyp24 Streptomyces avermitilis MA-4680 cytochrome P450 NP_827882.1 8020473 D 227882 CDS NP_827883.1 29833249 1217009 complement(8022004..8022969) 1 NC_003155.4 ribosomal pseudouridine synthase 8022969 1217009 SAV_6707 Streptomyces avermitilis MA-4680 ribosomal pseudouridine synthase NP_827883.1 8022004 R 227882 CDS NP_827884.1 29833250 1217010 8023104..8023706 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 8023706 1217010 SAV_6708 Streptomyces avermitilis MA-4680 acetyltransferase NP_827884.1 8023104 D 227882 CDS NP_827885.1 29833251 1217011 complement(8023722..8025302) 1 NC_003155.4 amino acid permease 8025302 1217011 SAV_6709 Streptomyces avermitilis MA-4680 amino acid permease NP_827885.1 8023722 R 227882 CDS NP_827886.1 29833252 1217012 8025589..8026236 1 NC_003155.4 ankyrin-like protein 8026236 1217012 SAV_6710 Streptomyces avermitilis MA-4680 ankyrin-like protein NP_827886.1 8025589 D 227882 CDS NP_827887.1 29833253 1217013 8026486..8027517 1 NC_003155.4 ABC transporter ATP-binding protein 8027517 1217013 SAV_6711 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_827887.1 8026486 D 227882 CDS NP_827888.1 29833254 1217014 8027514..8028290 1 NC_003155.4 multidrug ABC transporter permease 8028290 1217014 SAV_6712 Streptomyces avermitilis MA-4680 multidrug ABC transporter permease NP_827888.1 8027514 D 227882 CDS NP_827889.1 29833255 1217015 complement(8028311..8029159) 1 NC_003155.4 PF04954: Siderophore-interacting protein; siderophore-interacting protein 8029159 1217015 SAV_6713 Streptomyces avermitilis MA-4680 siderophore-interacting protein NP_827889.1 8028311 R 227882 CDS NP_827890.1 29833256 1217016 complement(8029222..8030151) 1 NC_003155.4 5'-3' exonuclease 8030151 1217016 SAV_6714 Streptomyces avermitilis MA-4680 5'-3' exonuclease NP_827890.1 8029222 R 227882 CDS NP_827891.1 29833257 1211545 8030365..8031444 1 NC_003155.4 glycine/betaine ABC transporter ATP-binding protein 8031444 opuAA 1211545 opuAA Streptomyces avermitilis MA-4680 glycine/betaine ABC transporter ATP-binding protein NP_827891.1 8030365 D 227882 CDS NP_827892.1 29833258 1211546 8031437..8034052 1 NC_003155.4 glycine/betaine ABC transporter permease 8034052 opuABC 1211546 opuABC Streptomyces avermitilis MA-4680 glycine/betaine ABC transporter permease NP_827892.1 8031437 D 227882 CDS NP_827893.1 29833259 1217017 8034155..8034835 1 NC_003155.4 hypothetical protein 8034835 1217017 SAV_6717 Streptomyces avermitilis MA-4680 hypothetical protein NP_827893.1 8034155 D 227882 CDS NP_827894.1 29833260 1217018 8035015..8035590 1 NC_003155.4 regulatory protein 8035590 1217018 SAV_6718 Streptomyces avermitilis MA-4680 regulatory protein NP_827894.1 8035015 D 227882 CDS NP_827895.1 29833261 1217019 8035685..8036482 1 NC_003155.4 methyltransferase 8036482 1217019 SAV_6719 Streptomyces avermitilis MA-4680 methyltransferase NP_827895.1 8035685 D 227882 CDS NP_827896.1 29833262 1217020 8036490..8037245 1 NC_003155.4 PF01497: Periplasmic binding protein; hypothetical protein 8037245 1217020 SAV_6720 Streptomyces avermitilis MA-4680 hypothetical protein NP_827896.1 8036490 D 227882 CDS NP_827897.1 29833263 1217021 complement(8037211..8038371) 1 NC_003155.4 PF03595: C4-dicarboxylate transporter/malic acid transport protein; integral membrane protein 8038371 1217021 SAV_6721 Streptomyces avermitilis MA-4680 integral membrane protein NP_827897.1 8037211 R 227882 CDS NP_827898.1 29833264 1217022 8038442..8039362 1 NC_003155.4 LysR family transcriptional regulator 8039362 1217022 SAV_6722 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_827898.1 8038442 D 227882 CDS NP_827899.1 29833265 1217023 complement(8039394..8040179) 1 NC_003155.4 PF00117: Glutamine amidotransferase class-I; hypothetical protein 8040179 1217023 SAV_6723 Streptomyces avermitilis MA-4680 hypothetical protein NP_827899.1 8039394 R 227882 CDS NP_827900.1 29833266 1217024 complement(8040205..8040981) 1 NC_003155.4 GntR family transcriptional regulator 8040981 1217024 SAV_6724 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_827900.1 8040205 R 227882 CDS NP_827901.1 29833267 1211547 8041036..8042400 1 NC_003155.4 glutamine synthetase 8042400 glnA4 1211547 glnA4 Streptomyces avermitilis MA-4680 glutamine synthetase NP_827901.1 8041036 D 227882 CDS NP_827902.1 29833268 1217025 8042397..8043788 1 NC_003155.4 phenylacetaldehyde dehydrogenase 8043788 feaB 1217025 feaB Streptomyces avermitilis MA-4680 phenylacetaldehyde dehydrogenase NP_827902.1 8042397 D 227882 CDS NP_827903.1 29833269 1217026 8043785..8044576 1 NC_003155.4 PF00106: short chain dehydrogenase; short chain dehydrogenase 8044576 1217026 SAV_6727 Streptomyces avermitilis MA-4680 short chain dehydrogenase NP_827903.1 8043785 D 227882 CDS NP_827904.1 29833270 1217027 8044652..8045866 1 NC_003155.4 lipoprotein 8045866 1217027 SAV_6728 Streptomyces avermitilis MA-4680 lipoprotein NP_827904.1 8044652 D 227882 CDS NP_827905.1 29833271 1217028 8045901..8046833 1 NC_003155.4 hypothetical protein 8046833 1217028 SAV_6729 Streptomyces avermitilis MA-4680 hypothetical protein NP_827905.1 8045901 D 227882 CDS NP_827906.1 29833272 1217029 complement(8046949..8048151) 1 NC_003155.4 PF01168: Alanine racemase, N-terminal domain; hypothetical protein 8048151 1217029 SAV_6730 Streptomyces avermitilis MA-4680 hypothetical protein NP_827906.1 8046949 R 227882 CDS NP_827907.1 29833273 1217030 complement(8048174..8049283) 1 NC_003155.4 hypothetical protein 8049283 1217030 SAV_6731 Streptomyces avermitilis MA-4680 hypothetical protein NP_827907.1 8048174 R 227882 CDS NP_827908.1 29833274 1217031 8049489..8050241 1 NC_003155.4 hypothetical protein 8050241 1217031 SAV_6732 Streptomyces avermitilis MA-4680 hypothetical protein NP_827908.1 8049489 D 227882 CDS NP_827909.1 29833275 1217032 8050238..8051458 1 NC_003155.4 PF00082: Subtilase family; serine protease 8051458 1217032 SAV_6733 Streptomyces avermitilis MA-4680 serine protease NP_827909.1 8050238 D 227882 CDS NP_827910.1 29833276 1217033 complement(8051504..8052454) 1 NC_003155.4 protein 8052454 1217033 SAV_6734 Streptomyces avermitilis MA-4680 protein NP_827910.1 8051504 R 227882 CDS NP_827911.1 29833277 1217034 8052605..8053336 1 NC_003155.4 hypothetical protein 8053336 1217034 SAV_6735 Streptomyces avermitilis MA-4680 hypothetical protein NP_827911.1 8052605 D 227882 CDS NP_827912.1 29833278 1217035 complement(8053489..8053845) 1 NC_003155.4 hypothetical protein 8053845 1217035 SAV_6736 Streptomyces avermitilis MA-4680 hypothetical protein NP_827912.1 8053489 R 227882 CDS NP_827913.1 29833279 1211548 8054233..8054958 1 NC_003155.4 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 8054958 infC 1211548 infC Streptomyces avermitilis MA-4680 translation initiation factor IF-3 NP_827913.1 8054233 D 227882 CDS NP_827914.1 29833280 1211549 8055065..8055259 1 NC_003155.4 50S ribosomal protein L35 8055259 rpmI 1211549 rpmI Streptomyces avermitilis MA-4680 50S ribosomal protein L35 NP_827914.1 8055065 D 227882 CDS NP_827915.1 29833281 1211550 8055355..8055738 1 NC_003155.4 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 8055738 rplT 1211550 rplT Streptomyces avermitilis MA-4680 50S ribosomal protein L20 NP_827915.1 8055355 D 227882 CDS NP_827916.1 29833282 1217036 8055796..8056722 1 NC_003155.4 PF00588: SpoU rRNA Methylase family; rRNA methyltransferase 8056722 tsnR2 1217036 tsnR2 Streptomyces avermitilis MA-4680 rRNA methyltransferase NP_827916.1 8055796 D 227882 CDS NP_827917.1 29833283 1217037 8056816..8057979 1 NC_003155.4 two-component system sensor kinase 8057979 1217037 SAV_6741 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_827917.1 8056816 D 227882 CDS NP_827918.1 29833284 1211551 8058206..8059288 1 NC_003155.4 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 8059288 pheS 1211551 pheS Streptomyces avermitilis MA-4680 phenylalanyl-tRNA synthetase subunit alpha NP_827918.1 8058206 D 227882 CDS NP_827919.1 29833285 1211552 8059288..8061789 1 NC_003155.4 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 8061789 pheT 1211552 pheT Streptomyces avermitilis MA-4680 phenylalanyl-tRNA synthetase subunit beta NP_827919.1 8059288 D 227882 CDS NP_827920.1 29833286 1217038 8062098..8063252 1 NC_003155.4 PF02673: Bacitracin resistance protein BacA; magnesium or manganese-dependent protein phosphatase 8063252 prpB12 1217038 prpB12 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_827920.1 8062098 D 227882 CDS NP_827921.1 29833287 1217039 8063589..8064929 1 NC_003155.4 PF06036: Streptomyces protein of unknown function (DUF921); transcriptional regulator 8064929 1217039 SAV_6745 Streptomyces avermitilis MA-4680 transcriptional regulator NP_827921.1 8063589 D 227882 CDS NP_827922.1 29833288 1217040 8065084..8065629 1 NC_003155.4 PF00293: NUDIX domain; hypothetical protein 8065629 1217040 SAV_6746 Streptomyces avermitilis MA-4680 hypothetical protein NP_827922.1 8065084 D 227882 CDS NP_827923.1 29833289 1217041 complement(8065650..8065961) 1 NC_003155.4 hypothetical protein 8065961 1217041 SAV_6747 Streptomyces avermitilis MA-4680 hypothetical protein NP_827923.1 8065650 R 227882 CDS NP_827924.1 29833290 1211553 complement(8066129..8067010) 1 NC_003155.4 converts (S)-3-hydroxybutanoyl-CoA to 3-acetoacetyl-CoA; 3-hydroxybutyryl-CoA dehydrogenase 8067010 fadC5 1211553 fadC5 Streptomyces avermitilis MA-4680 3-hydroxybutyryl-CoA dehydrogenase NP_827924.1 8066129 R 227882 CDS NP_827925.1 29833291 1217042 8067170..8068423 1 NC_003155.4 PF02638: Uncharacterized BCR, COG1649; protein 8068423 1217042 SAV_6749 Streptomyces avermitilis MA-4680 protein NP_827925.1 8067170 D 227882 CDS NP_827926.1 29833292 1217043 complement(8068425..8068625) 1 NC_003155.4 hypothetical protein 8068625 1217043 SAV_6750 Streptomyces avermitilis MA-4680 hypothetical protein NP_827926.1 8068425 R 227882 CDS NP_827927.1 29833293 1217044 complement(8068730..8069749) 1 NC_003155.4 PF00892: Integral membrane protein DUF6; integral membrane protein 8069749 1217044 SAV_6751 Streptomyces avermitilis MA-4680 integral membrane protein NP_827927.1 8068730 R 227882 CDS NP_827928.1 29833294 1217045 8069871..8071181 1 NC_003155.4 transcriptional regulator 8071181 1217045 SAV_6752 Streptomyces avermitilis MA-4680 transcriptional regulator NP_827928.1 8069871 D 227882 CDS NP_827929.1 29833295 1217046 8071286..8071726 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 8071726 1217046 SAV_6753 Streptomyces avermitilis MA-4680 acetyltransferase NP_827929.1 8071286 D 227882 CDS NP_827930.1 29833296 1217047 8071818..8072402 1 NC_003155.4 PF00300: Phosphoglycerate mutase family; hypothetical protein 8072402 1217047 SAV_6754 Streptomyces avermitilis MA-4680 hypothetical protein NP_827930.1 8071818 D 227882 CDS NP_827931.1 29833297 1217048 complement(8072399..8072869) 1 NC_003155.4 hypothetical protein 8072869 1217048 SAV_6755 Streptomyces avermitilis MA-4680 hypothetical protein NP_827931.1 8072399 R 227882 CDS NP_827932.1 29833298 1217049 8073187..8075319 1 NC_003155.4 arabinosidase 8075319 1217049 SAV_6756 Streptomyces avermitilis MA-4680 arabinosidase NP_827932.1 8073187 D 227882 CDS NP_827933.1 29833299 1217050 complement(8075306..8075743) 1 NC_003155.4 carboxymuconolactone decarboxylase 8075743 1217050 SAV_6757 Streptomyces avermitilis MA-4680 carboxymuconolactone decarboxylase NP_827933.1 8075306 R 227882 CDS NP_827934.1 29833300 1217051 complement(8075740..8076159) 1 NC_003155.4 MerR family transcriptional regulator 8076159 1217051 SAV_6758 Streptomyces avermitilis MA-4680 MerR family transcriptional regulator NP_827934.1 8075740 R 227882 CDS NP_827935.1 29833301 1217052 complement(8076350..8076988) 1 NC_003155.4 hypothetical protein 8076988 1217052 SAV_6759 Streptomyces avermitilis MA-4680 hypothetical protein NP_827935.1 8076350 R 227882 CDS NP_827936.1 29833302 1217053 complement(8077051..8078250) 1 NC_003155.4 hypothetical protein 8078250 1217053 SAV_6760 Streptomyces avermitilis MA-4680 hypothetical protein NP_827936.1 8077051 R 227882 CDS NP_827937.1 29833303 1217054 complement(8078247..8078690) 1 NC_003155.4 hypothetical protein 8078690 1217054 SAV_6761 Streptomyces avermitilis MA-4680 hypothetical protein NP_827937.1 8078247 R 227882 CDS NP_827938.1 29833304 1217055 complement(8078754..8079557) 1 NC_003155.4 hydroxylase 8079557 1217055 SAV_6762 Streptomyces avermitilis MA-4680 hydroxylase NP_827938.1 8078754 R 227882 CDS NP_827939.1 29833305 1211554 8079875..8080903 1 NC_003155.4 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 8080903 argC 1211554 argC Streptomyces avermitilis MA-4680 N-acetyl-gamma-glutamyl-phosphate reductase NP_827939.1 8079875 D 227882 CDS NP_827940.1 29833306 1211555 8080900..8082051 1 NC_003155.4 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate; bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein 8082051 argJ 1211555 argJ Streptomyces avermitilis MA-4680 bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein NP_827940.1 8080900 D 227882 CDS NP_827941.1 29833307 1211556 8082048..8082962 1 NC_003155.4 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 8082962 argB 1211556 argB Streptomyces avermitilis MA-4680 acetylglutamate kinase NP_827941.1 8082048 D 227882 CDS NP_827942.1 29833308 1211557 8082959..8084170 1 NC_003155.4 catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine; acetylornithine aminotransferase 8084170 argD 1211557 argD Streptomyces avermitilis MA-4680 acetylornithine aminotransferase NP_827942.1 8082959 D 227882 CDS NP_827943.1 29833309 1211558 8084178..8084714 1 NC_003155.4 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor 8084714 argR 1211558 argR Streptomyces avermitilis MA-4680 arginine repressor NP_827943.1 8084178 D 227882 CDS NP_827944.1 29833310 1211559 complement(8084841..8085578) 1 NC_003155.4 thiamine biosynthesis lipoprotein precursor 8085578 apbE2 1211559 apbE2 Streptomyces avermitilis MA-4680 thiamine biosynthesis lipoprotein precursor NP_827944.1 8084841 R 227882 CDS NP_827945.1 29833311 1217056 complement(8085634..8086422) 1 NC_003155.4 PF04205: FMN-binding domain; hypothetical protein 8086422 1217056 SAV_6769 Streptomyces avermitilis MA-4680 hypothetical protein NP_827945.1 8085634 R 227882 CDS NP_827946.1 29833312 1217057 complement(8086442..8087821) 1 NC_003155.4 PF00175: Oxidoreductase NAD-binding domain; oxidoreductase 8087821 1217057 SAV_6770 Streptomyces avermitilis MA-4680 oxidoreductase NP_827946.1 8086442 R 227882 CDS NP_827947.1 29833313 1217058 complement(8087905..8088402) 1 NC_003155.4 PF04205: FMN-binding domain; hypothetical protein 8088402 1217058 SAV_6771 Streptomyces avermitilis MA-4680 hypothetical protein NP_827947.1 8087905 R 227882 CDS NP_827948.1 29833314 1217059 complement(8088410..8089771) 1 NC_003155.4 PF00175: Oxidoreductase NAD-binding domain; oxidoreductase 8089771 1217059 SAV_6772 Streptomyces avermitilis MA-4680 oxidoreductase NP_827948.1 8088410 R 227882 CDS NP_827949.1 29833315 1217060 8089920..8090708 1 NC_003155.4 two-component system response regulator 8090708 1217060 SAV_6773 Streptomyces avermitilis MA-4680 two-component system response regulator NP_827949.1 8089920 D 227882 CDS NP_827950.1 29833316 1217061 8090705..8092219 1 NC_003155.4 two-component system sensor kinase 8092219 1217061 SAV_6774 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_827950.1 8090705 D 227882 CDS NP_827951.1 29833317 1217062 complement(8092272..8092973) 1 NC_003155.4 protein 8092973 1217062 SAV_6775 Streptomyces avermitilis MA-4680 protein NP_827951.1 8092272 R 227882 CDS NP_827952.1 29833318 1217063 complement(8092977..8093564) 1 NC_003155.4 PF01243: Pyridoxamine 5'-phosphate oxidase; hypothetical protein 8093564 1217063 SAV_6776 Streptomyces avermitilis MA-4680 hypothetical protein NP_827952.1 8092977 R 227882 CDS NP_827953.1 29833319 1217064 complement(8093803..8094708) 1 NC_003155.4 hypothetical protein 8094708 1217064 SAV_6777 Streptomyces avermitilis MA-4680 hypothetical protein NP_827953.1 8093803 R 227882 CDS NP_827954.1 29833320 1211560 8094879..8096093 1 NC_003155.4 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 8096093 argG2 1211560 argG2 Streptomyces avermitilis MA-4680 argininosuccinate synthase NP_827954.1 8094879 D 227882 CDS NP_827955.1 29833321 1211561 8096194..8097627 1 NC_003155.4 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 8097627 argH 1211561 argH Streptomyces avermitilis MA-4680 argininosuccinate lyase NP_827955.1 8096194 D 227882 CDS NP_827956.1 29833322 1217065 8097662..8098675 1 NC_003155.4 PF00248: Aldo/keto reductase family; oxidoreductase 8098675 1217065 SAV_6780 Streptomyces avermitilis MA-4680 oxidoreductase NP_827956.1 8097662 D 227882 CDS NP_827957.1 29833323 1217066 8098734..8099312 1 NC_003155.4 TetR family transcriptional regulator 8099312 1217066 SAV_6781 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_827957.1 8098734 D 227882 CDS NP_827958.1 29833324 1217067 8099309..8100826 1 NC_003155.4 PF07690: Major Facilitator Superfamily; multidrug resistance efflux protein 8100826 1217067 SAV_6782 Streptomyces avermitilis MA-4680 multidrug resistance efflux protein NP_827958.1 8099309 D 227882 CDS NP_827959.1 29833325 1211562 complement(8100895..8101566) 1 NC_003155.4 1-acylglycerol-3-phosphate O-acyltransferase 8101566 plsC4 1211562 plsC4 Streptomyces avermitilis MA-4680 1-acylglycerol-3-phosphate O-acyltransferase NP_827959.1 8100895 R 227882 CDS NP_827960.1 29833326 1211563 8101953..8103134 1 NC_003155.4 glycerophosphoryl diester phosphodiesterase 8103134 glpQ3 1211563 glpQ3 Streptomyces avermitilis MA-4680 glycerophosphoryl diester phosphodiesterase NP_827960.1 8101953 D 227882 CDS NP_827961.1 29833327 1211564 8103254..8103760 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 8103760 sig54 1211564 sig54 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_827961.1 8103254 D 227882 CDS NP_827962.1 29833328 1217068 8103785..8104303 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 8104303 1217068 SAV_6786 Streptomyces avermitilis MA-4680 acetyltransferase NP_827962.1 8103785 D 227882 CDS NP_827963.1 29833329 1217069 complement(8104529..8104981) 1 NC_003155.4 integral membrane protein 8104981 1217069 SAV_6787 Streptomyces avermitilis MA-4680 integral membrane protein NP_827963.1 8104529 R 227882 CDS NP_827964.1 29833330 1217070 complement(8104962..8105321) 1 NC_003155.4 integral membrane protein 8105321 1217070 SAV_6788 Streptomyces avermitilis MA-4680 integral membrane protein NP_827964.1 8104962 R 227882 CDS NP_827965.1 29833331 1217071 8105882..8106982 1 NC_003155.4 ABC transporter ATP-binding protein 8106982 1217071 SAV_6789 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_827965.1 8105882 D 227882 CDS NP_827966.1 29833332 1217072 8106979..8107758 1 NC_003155.4 ABC transporter permease 8107758 1217072 SAV_6790 Streptomyces avermitilis MA-4680 ABC transporter permease NP_827966.1 8106979 D 227882 CDS NP_827967.1 29833333 1217073 8107830..8108657 1 NC_003155.4 ABC transporter substrate-binding protein 8108657 1217073 SAV_6791 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_827967.1 8107830 D 227882 CDS NP_827968.1 29833334 1217074 8108671..8109510 1 NC_003155.4 ABC transporter substrate-binding protein 8109510 1217074 SAV_6792 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_827968.1 8108671 D 227882 CDS NP_827969.1 29833335 1217075 8109643..8110281 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 8110281 1217075 SAV_6793 Streptomyces avermitilis MA-4680 acetyltransferase NP_827969.1 8109643 D 227882 CDS NP_827970.1 29833336 1217076 8110412..8111623 1 NC_003155.4 cobalamin biosynthesis; precorrin-6Y C5,15-methyltransferase 8111623 cobL2 1217076 cobL2 Streptomyces avermitilis MA-4680 precorrin-6Y C5,15-methyltransferase NP_827970.1 8110412 D 227882 CDS NP_827971.1 29833337 1211565 8111969..8115829 1 NC_003155.4 cobalamin biosynthesis; nicotinate-nucleotide- dimethylbenzimidazole phosphoribosyltransferase 8115829 cobT2 1211565 cobT2 Streptomyces avermitilis MA-4680 nicotinate-nucleotide- dimethylbenzimidazole phosphoribosyltransferase NP_827971.1 8111969 D 227882 CDS NP_827972.1 29833338 1211566 8115977..8117209 1 NC_003155.4 uroporphyrin-III methyltransferase 8117209 cysG 1211566 cysG Streptomyces avermitilis MA-4680 uroporphyrin-III methyltransferase NP_827972.1 8115977 D 227882 CDS NP_827973.1 29833339 1217077 8117274..8118092 1 NC_003155.4 rRNA methylase 8118092 1217077 SAV_6797 Streptomyces avermitilis MA-4680 rRNA methylase NP_827973.1 8117274 D 227882 CDS NP_827974.1 29833340 1217078 8118108..8118503 1 NC_003155.4 mutT-like protein 8118503 1217078 SAV_6798 Streptomyces avermitilis MA-4680 mutT-like protein NP_827974.1 8118108 D 227882 CDS NP_827975.1 29833341 1211567 complement(8118587..8119888) 1 NC_003155.4 serine/threonine protein kinase 8119888 pkn30 1211567 pkn30 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_827975.1 8118587 R 227882 CDS NP_827976.1 29833342 1217079 8120530..8120739 1 NC_003155.4 hypothetical protein 8120739 1217079 SAV_6800 Streptomyces avermitilis MA-4680 hypothetical protein NP_827976.1 8120530 D 227882 CDS NP_827977.1 29833343 1217080 8120921..8121856 1 NC_003155.4 PF01636: Phosphotransferase enzyme family; hypothetical protein 8121856 1217080 SAV_6801 Streptomyces avermitilis MA-4680 hypothetical protein NP_827977.1 8120921 D 227882 CDS NP_827978.1 29833344 1217081 8121958..8122224 1 NC_003155.4 hypothetical protein 8122224 1217081 SAV_6802 Streptomyces avermitilis MA-4680 hypothetical protein NP_827978.1 8121958 D 227882 CDS NP_827979.1 29833345 1211573 8122893..8124014 1 NC_003155.4 PF00425: chorismate binding enzyme; anthranilate synthase 8124014 pabB 1211573 pabB Streptomyces avermitilis MA-4680 anthranilate synthase NP_827979.1 8122893 D 227882 CDS NP_827980.1 29833346 1217082 8124011..8124832 1 NC_003155.4 PF01063: Aminotransferase class IV; D-alanine aminotransferase 8124832 1217082 SAV_6804 Streptomyces avermitilis MA-4680 D-alanine aminotransferase NP_827980.1 8124011 D 227882 CDS NP_827981.1 29833347 1217083 8124859..8125713 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 8125713 1217083 SAV_6805 Streptomyces avermitilis MA-4680 acetyltransferase NP_827981.1 8124859 D 227882 CDS NP_827982.1 29833348 1217084 complement(8125820..8126350) 1 NC_003155.4 PF01323: DSBA-like thioredoxin domain; hypothetical protein 8126350 1217084 SAV_6806 Streptomyces avermitilis MA-4680 hypothetical protein NP_827982.1 8125820 R 227882 CDS NP_827983.1 29833349 1217085 8126556..8126999 1 NC_003155.4 hypothetical protein 8126999 1217085 SAV_6807 Streptomyces avermitilis MA-4680 hypothetical protein NP_827983.1 8126556 D 227882 CDS NP_827984.1 29833350 1217086 8127180..8127332 1 NC_003155.4 hypothetical protein 8127332 1217086 SAV_6808 Streptomyces avermitilis MA-4680 hypothetical protein NP_827984.1 8127180 D 227882 CDS NP_827985.1 29833351 1217087 complement(8127548..8128108) 1 NC_003155.4 PF07336: Protein of unknown function (DUF1470); hypothetical protein 8128108 1217087 SAV_6809 Streptomyces avermitilis MA-4680 hypothetical protein NP_827985.1 8127548 R 227882 CDS NP_827986.1 29833352 1217088 complement(8128420..8128899) 1 NC_003155.4 PF04686: Streptomyces sporulation and cell division protein, SsgA; cell division protein, regulatory protein 8128899 ssgA2 1217088 ssgA2 Streptomyces avermitilis MA-4680 cell division protein, regulatory protein NP_827986.1 8128420 R 227882 CDS NP_827987.1 29833353 1217089 8129024..8129458 1 NC_003155.4 hypothetical protein 8129458 1217089 SAV_6811 Streptomyces avermitilis MA-4680 hypothetical protein NP_827987.1 8129024 D 227882 CDS NP_827988.1 29833354 1217090 8130180..8131466 1 NC_003155.4 ABC transporter substrate-binding protein 8131466 1217090 SAV_6812 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_827988.1 8130180 D 227882 CDS NP_827989.1 29833355 1217091 8131463..8132434 1 NC_003155.4 ABC transporter permease 8132434 1217091 SAV_6813 Streptomyces avermitilis MA-4680 ABC transporter permease NP_827989.1 8131463 D 227882 CDS NP_827990.1 29833356 1217092 8132404..8133312 1 NC_003155.4 ABC transporter permease 8133312 1217092 SAV_6814 Streptomyces avermitilis MA-4680 ABC transporter permease NP_827990.1 8132404 D 227882 CDS NP_827991.1 29833357 1217093 8133314..8133961 1 NC_003155.4 hypothetical protein 8133961 1217093 SAV_6815 Streptomyces avermitilis MA-4680 hypothetical protein NP_827991.1 8133314 D 227882 CDS NP_827992.1 29833358 1217094 8134457..8136928 1 NC_003155.4 hypothetical protein 8136928 1217094 SAV_6816 Streptomyces avermitilis MA-4680 hypothetical protein NP_827992.1 8134457 D 227882 CDS NP_827993.1 29833359 1217095 complement(8136947..8139337) 1 NC_003155.4 PF01970: Integral membrane protein DUF112; integral membrane protein 8139337 1217095 SAV_6817 Streptomyces avermitilis MA-4680 integral membrane protein NP_827993.1 8136947 R 227882 CDS NP_827994.1 29833360 1217096 8139440..8139898 1 NC_003155.4 PF03364: Streptomyces cyclase/dehydrase; hypothetical protein 8139898 1217096 SAV_6818 Streptomyces avermitilis MA-4680 hypothetical protein NP_827994.1 8139440 D 227882 CDS NP_827995.1 29833361 1211576 complement(8140086..8140811) 1 NC_003155.4 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 8140811 dnaQ2 1211576 dnaQ2 Streptomyces avermitilis MA-4680 DNA polymerase III subunit epsilon NP_827995.1 8140086 R 227882 CDS NP_827996.1 29833362 1217097 8140980..8141546 1 NC_003155.4 hypothetical protein 8141546 1217097 SAV_6820 Streptomyces avermitilis MA-4680 hypothetical protein NP_827996.1 8140980 D 227882 CDS NP_827997.1 29833363 1217098 8141543..8142763 1 NC_003155.4 hypothetical protein 8142763 1217098 SAV_6821 Streptomyces avermitilis MA-4680 hypothetical protein NP_827997.1 8141543 D 227882 CDS NP_827998.1 29833364 1211577 8142864..8144840 1 NC_003155.4 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 8144840 thrS 1211577 thrS Streptomyces avermitilis MA-4680 threonyl-tRNA synthetase NP_827998.1 8142864 D 227882 CDS NP_827999.1 29833365 1217099 8145199..8145762 1 NC_003155.4 HIT family protein 8145762 1217099 SAV_6823 Streptomyces avermitilis MA-4680 HIT family protein NP_827999.1 8145199 D 227882 CDS NP_828000.1 29833366 1217100 complement(8145882..8147543) 1 NC_003155.4 hypothetical protein 8147543 1217100 SAV_6824 Streptomyces avermitilis MA-4680 hypothetical protein NP_828000.1 8145882 R 227882 CDS NP_828001.1 29833367 1211578 complement(8147772..8149970) 1 NC_003155.4 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 8149970 fusA2 1211578 fusA2 Streptomyces avermitilis MA-4680 elongation factor G NP_828001.1 8147772 R 227882 CDS NP_828002.1 29833368 1217101 8150189..8150923 1 NC_003155.4 PF01066: CDP-alcohol phosphatidyltransferase; phosphatidylglycerophosphate synthase 8150923 pgsA2 1217101 pgsA2 Streptomyces avermitilis MA-4680 phosphatidylglycerophosphate synthase NP_828002.1 8150189 D 227882 CDS NP_828003.1 29833369 1211579 8150920..8151846 1 NC_003155.4 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 8151846 plsC5 1211579 plsC5 Streptomyces avermitilis MA-4680 lipid A biosynthesis lauroyl acyltransferase NP_828003.1 8150920 D 227882 CDS NP_828004.1 29833370 1217102 8151843..8153003 1 NC_003155.4 glycosyltransferase 8153003 1217102 SAV_6828 Streptomyces avermitilis MA-4680 glycosyltransferase NP_828004.1 8151843 D 227882 CDS NP_828005.1 29833371 1217103 8153398..8153952 1 NC_003155.4 protein 8153952 1217103 SAV_6829 Streptomyces avermitilis MA-4680 protein NP_828005.1 8153398 D 227882 CDS NP_828006.1 29833372 1211580 8154087..8155001 1 NC_003155.4 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 8155001 pdx1 1211580 pdx1 Streptomyces avermitilis MA-4680 pyridoxal biosynthesis lyase PdxS NP_828006.1 8154087 D 227882 CDS NP_828007.1 29833373 1217104 8155015..8155620 1 NC_003155.4 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 8155620 1217104 SAV_6831 Streptomyces avermitilis MA-4680 glutamine amidotransferase subunit PdxT NP_828007.1 8155015 D 227882 CDS NP_828008.1 29833374 1217105 8155698..8156450 1 NC_003155.4 PF01709: Domain of unknown function DUF28; hypothetical protein 8156450 1217105 SAV_6832 Streptomyces avermitilis MA-4680 hypothetical protein NP_828008.1 8155698 D 227882 CDS NP_828009.1 29833375 1211581 8156649..8157179 1 NC_003155.4 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 8157179 ruvC 1211581 ruvC Streptomyces avermitilis MA-4680 Holliday junction resolvase NP_828009.1 8156649 D 227882 CDS NP_828010.1 29833376 1211582 8157176..8157787 1 NC_003155.4 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 8157787 ruvA 1211582 ruvA Streptomyces avermitilis MA-4680 Holliday junction DNA helicase RuvA NP_828010.1 8157176 D 227882 CDS NP_828011.1 29833377 1211583 8157959..8159029 1 NC_003155.4 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 8159029 ruvB 1211583 ruvB Streptomyces avermitilis MA-4680 Holliday junction DNA helicase RuvB NP_828011.1 8157959 D 227882 CDS NP_828012.1 29833378 1217106 8159193..8159696 1 NC_003155.4 PF02699: Preprotein translocase subunit; protein 8159696 1217106 SAV_6836 Streptomyces avermitilis MA-4680 protein NP_828012.1 8159193 D 227882 CDS NP_828013.1 29833379 1211584 8159839..8161593 1 NC_003155.4 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 8161593 secD 1211584 secD Streptomyces avermitilis MA-4680 preprotein translocase subunit SecD NP_828013.1 8159839 D 227882 CDS NP_828014.1 29833380 1211585 8161595..8162701 1 NC_003155.4 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 8162701 secF 1211585 secF Streptomyces avermitilis MA-4680 preprotein translocase subunit SecF NP_828014.1 8161595 D 227882 CDS NP_828015.1 29833381 1211586 8162698..8163246 1 NC_003155.4 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 8163246 apt 1211586 apt Streptomyces avermitilis MA-4680 adenine phosphoribosyltransferase NP_828015.1 8162698 D 227882 CDS NP_828016.1 29833382 1211587 8164005..8166542 1 NC_003155.4 PF04607: Region found in RelA / SpoT proteins; ppGpp synthetase 8166542 relA2 1211587 relA2 Streptomyces avermitilis MA-4680 ppGpp synthetase NP_828016.1 8164005 D 227882 CDS NP_828017.1 29833383 1217107 complement(8166677..8167906) 1 NC_003155.4 PF03993: Domain of Unknown Function (DUF349); hypothetical protein 8167906 1217107 SAV_6841 Streptomyces avermitilis MA-4680 hypothetical protein NP_828017.1 8166677 R 227882 CDS NP_828018.1 29833384 1211588 complement(8168042..8168875) 1 NC_003155.4 peptidyl-prolyl cis-trans isomerase 8168875 ppiB 1211588 ppiB Streptomyces avermitilis MA-4680 peptidyl-prolyl cis-trans isomerase NP_828018.1 8168042 R 227882 CDS NP_828019.1 29833385 1217108 8169042..8169749 1 NC_003155.4 PF00753: Metallo-beta-lactamase superfamily; hydrolase 8169749 1217108 SAV_6843 Streptomyces avermitilis MA-4680 hydrolase NP_828019.1 8169042 D 227882 CDS NP_828020.1 29833386 1211589 8169763..8171025 1 NC_003155.4 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 8171025 hisS 1211589 hisS Streptomyces avermitilis MA-4680 histidyl-tRNA synthetase NP_828020.1 8169763 D 227882 CDS NP_828021.1 29833387 1217109 8171593..8172231 1 NC_003155.4 integral membrane protein 8172231 1217109 SAV_6845 Streptomyces avermitilis MA-4680 integral membrane protein NP_828021.1 8171593 D 227882 CDS NP_828022.1 29833388 1217110 8172295..8173656 1 NC_003155.4 recombination factor protein RarA 8173656 1217110 SAV_6846 Streptomyces avermitilis MA-4680 recombination factor protein RarA NP_828022.1 8172295 D 227882 CDS NP_828023.1 29833389 1211590 8173971..8174585 1 NC_003155.4 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 8174585 rpsD 1211590 rpsD Streptomyces avermitilis MA-4680 30S ribosomal protein S4 NP_828023.1 8173971 D 227882 CDS NP_828024.1 29833390 1217111 8174761..8175216 1 NC_003155.4 PF05962: Bacterial protein of unknown function (DUF886); protein 8175216 1217111 SAV_6848 Streptomyces avermitilis MA-4680 protein NP_828024.1 8174761 D 227882 CDS NP_828025.1 29833391 1217112 8175224..8175574 1 NC_003155.4 protein 8175574 1217112 SAV_6849 Streptomyces avermitilis MA-4680 protein NP_828025.1 8175224 D 227882 CDS NP_828026.1 29833392 1211591 8175574..8178246 1 NC_003155.4 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 8178246 alaS 1211591 alaS Streptomyces avermitilis MA-4680 alanyl-tRNA synthetase NP_828026.1 8175574 D 227882 CDS NP_828027.1 29833393 1217113 8178256..8178726 1 NC_003155.4 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 8178726 1217113 SAV_6851 Streptomyces avermitilis MA-4680 Holliday junction resolvase-like protein NP_828027.1 8178256 D 227882 CDS NP_828028.1 29833394 1217114 8178852..8180669 1 NC_003155.4 PF02618: Aminodeoxychorismate lyase, a pyridoxal 5'-phosphate-dependent enzyme that converts 4-aminodeoxychorismate to pyruvate and p-aminobenzoate; aminodeoxychorismate lyase 8180669 1217114 SAV_6852 Streptomyces avermitilis MA-4680 aminodeoxychorismate lyase NP_828028.1 8178852 D 227882 CDS NP_828029.1 29833395 1211592 8180666..8181502 1 NC_003155.4 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 8181502 aroE 1211592 aroE Streptomyces avermitilis MA-4680 shikimate 5-dehydrogenase NP_828029.1 8180666 D 227882 CDS NP_828030.1 29833396 1211593 8181892..8183076 1 NC_003155.4 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 8183076 aroC 1211593 aroC Streptomyces avermitilis MA-4680 chorismate synthase NP_828030.1 8181892 D 227882 CDS NP_828031.1 29833397 1211594 8183073..8183588 1 NC_003155.4 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 8183588 aroK 1211594 aroK Streptomyces avermitilis MA-4680 shikimate kinase NP_828031.1 8183073 D 227882 CDS NP_828032.1 29833398 1211595 8183585..8184676 1 NC_003155.4 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 8184676 aroB 1211595 aroB Streptomyces avermitilis MA-4680 3-dehydroquinate synthase NP_828032.1 8183585 D 227882 CDS NP_828033.1 29833399 1217115 8184843..8185733 1 NC_003155.4 hypothetical protein 8185733 1217115 SAV_6857 Streptomyces avermitilis MA-4680 hypothetical protein NP_828033.1 8184843 D 227882 CDS NP_828034.1 29833400 1217116 8185869..8186975 1 NC_003155.4 PF00557: metallopeptidase family M24; peptidase 8186975 1217116 SAV_6858 Streptomyces avermitilis MA-4680 peptidase NP_828034.1 8185869 D 227882 CDS NP_828035.1 29833401 1211596 8187035..8187601 1 NC_003155.4 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 8187601 efp 1211596 efp Streptomyces avermitilis MA-4680 elongation factor P NP_828035.1 8187035 D 227882 CDS NP_828036.1 29833402 1211597 8187604..8188038 1 NC_003155.4 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 8188038 nusB 1211597 nusB Streptomyces avermitilis MA-4680 transcription antitermination protein NusB NP_828036.1 8187604 D 227882 CDS NP_828037.1 29833403 1217117 complement(8188808..8189332) 1 NC_003155.4 DNA-binding protein 8189332 1217117 SAV_6861 Streptomyces avermitilis MA-4680 DNA-binding protein NP_828037.1 8188808 R 227882 CDS NP_828038.1 29833404 1211598 8189574..8190152 1 NC_003155.4 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase 8190152 pyrR 1211598 pyrR Streptomyces avermitilis MA-4680 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase NP_828038.1 8189574 D 227882 CDS NP_828039.1 29833405 1211599 8190239..8191216 1 NC_003155.4 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit 8191216 pyrB 1211599 pyrB Streptomyces avermitilis MA-4680 aspartate carbamoyltransferase catalytic subunit NP_828039.1 8190239 D 227882 CDS NP_828040.1 29833406 1211600 8191222..8192508 1 NC_003155.4 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 8192508 pyrC 1211600 pyrC Streptomyces avermitilis MA-4680 dihydroorotase NP_828040.1 8191222 D 227882 CDS NP_828041.1 29833407 1217118 8192505..8193125 1 NC_003155.4 integral membrane protein 8193125 1217118 SAV_6865 Streptomyces avermitilis MA-4680 integral membrane protein NP_828041.1 8192505 D 227882 CDS NP_828042.1 29833408 1211601 8193122..8194264 1 NC_003155.4 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 8194264 carA 1211601 carA Streptomyces avermitilis MA-4680 carbamoyl phosphate synthase small subunit NP_828042.1 8193122 D 227882 CDS NP_828043.1 29833409 1211602 8194257..8197565 1 NC_003155.4 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 8197565 carB 1211602 carB Streptomyces avermitilis MA-4680 carbamoyl phosphate synthase large subunit NP_828043.1 8194257 D 227882 CDS NP_828044.1 29833410 1211603 8197641..8198747 1 NC_003155.4 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 8198747 pyrD 1211603 pyrD Streptomyces avermitilis MA-4680 dihydroorotate dehydrogenase 2 NP_828044.1 8197641 D 227882 CDS NP_828045.1 29833411 1211604 8198744..8199586 1 NC_003155.4 type 2 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 8199586 pyrF 1211604 pyrF Streptomyces avermitilis MA-4680 orotidine 5'-phosphate decarboxylase NP_828045.1 8198744 D 227882 CDS NP_828046.1 29833412 1217119 8199842..8200165 1 NC_003155.4 hypothetical protein 8200165 1217119 SAV_6870 Streptomyces avermitilis MA-4680 hypothetical protein NP_828046.1 8199842 D 227882 CDS NP_828047.1 29833413 1211605 8200203..8200796 1 NC_003155.4 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 8200796 gmk 1211605 gmk Streptomyces avermitilis MA-4680 guanylate kinase NP_828047.1 8200203 D 227882 CDS NP_828048.1 29833414 1211606 8200837..8201109 1 NC_003155.4 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 8201109 rpoZ 1211606 rpoZ Streptomyces avermitilis MA-4680 DNA-directed RNA polymerase subunit omega NP_828048.1 8200837 D 227882 CDS NP_828049.1 29833415 1211607 8201233..8202450 1 NC_003155.4 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 8202450 dfp 1211607 dfp Streptomyces avermitilis MA-4680 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase NP_828049.1 8201233 D 227882 CDS NP_828050.1 29833416 1211608 8202691..8203899 1 NC_003155.4 methionine adenosyltransferase; catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 8203899 metK 1211608 metK Streptomyces avermitilis MA-4680 S-adenosylmethionine synthetase NP_828050.1 8202691 D 227882 CDS NP_828051.1 29833417 1211609 8204328..8206490 1 NC_003155.4 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 8206490 priA 1211609 priA Streptomyces avermitilis MA-4680 primosome assembly protein PriA NP_828051.1 8204328 D 227882 CDS NP_828052.1 29833418 1217120 complement(8206683..8207225) 1 NC_003155.4 hypothetical protein 8207225 1217120 SAV_6876 Streptomyces avermitilis MA-4680 hypothetical protein NP_828052.1 8206683 R 227882 CDS NP_828053.1 29833419 1211610 8207585..8208517 1 NC_003155.4 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 8208517 fmt 1211610 fmt Streptomyces avermitilis MA-4680 methionyl-tRNA formyltransferase NP_828053.1 8207585 D 227882 CDS NP_828054.1 29833420 1217121 8209360..8210790 1 NC_003155.4 PF01189: NOL1/NOP2/sun family; RNA-binding Sun protein 8210790 1217121 SAV_6878 Streptomyces avermitilis MA-4680 RNA-binding Sun protein NP_828054.1 8209360 D 227882 CDS NP_828055.1 29833421 1217122 complement(8210771..8212927) 1 NC_003155.4 similar to actII-3, PF03176: MMPL family; hypothetical protein 8212927 1217122 SAV_6879 Streptomyces avermitilis MA-4680 hypothetical protein NP_828055.1 8210771 R 227882 CDS NP_828056.1 29833422 1211611 8213111..8213797 1 NC_003155.4 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 8213797 rpe 1211611 rpe Streptomyces avermitilis MA-4680 ribulose-phosphate 3-epimerase NP_828056.1 8213111 D 227882 CDS NP_828057.1 29833423 1217123 8213876..8214919 1 NC_003155.4 transcriptional regulator 8214919 1217123 SAV_6881 Streptomyces avermitilis MA-4680 transcriptional regulator NP_828057.1 8213876 D 227882 CDS NP_828058.1 29833424 1217124 8214961..8215368 1 NC_003155.4 PF00545: ribonuclease; guanyl-specific ribonuclease Sa3 precursor (RNase Sa3) 8215368 1217124 SAV_6882 Streptomyces avermitilis MA-4680 guanyl-specific ribonuclease Sa3 precursor (RNase Sa3) NP_828058.1 8214961 D 227882 CDS NP_828059.1 29833425 1217125 8215365..8215742 1 NC_003155.4 hypothetical protein 8215742 1217125 SAV_6883 Streptomyces avermitilis MA-4680 hypothetical protein NP_828059.1 8215365 D 227882 CDS NP_828060.1 29833426 1211612 8215841..8217292 1 NC_003155.4 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5-monophosphate dehydrogenase 8217292 guaB3 1211612 guaB3 Streptomyces avermitilis MA-4680 inosine 5-monophosphate dehydrogenase NP_828060.1 8215841 D 227882 CDS NP_828061.1 29833427 1217126 8217379..8217879 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 8217879 1217126 SAV_6885 Streptomyces avermitilis MA-4680 acetyltransferase NP_828061.1 8217379 D 227882 CDS NP_828062.1 29833428 1217127 8218131..8219609 1 NC_003155.4 amino acid permease 8219609 1217127 SAV_6886 Streptomyces avermitilis MA-4680 amino acid permease NP_828062.1 8218131 D 227882 CDS NP_828063.1 29833429 1217128 8219620..8220072 1 NC_003155.4 transcription regulator AsnC 8220072 1217128 SAV_6887 Streptomyces avermitilis MA-4680 transcription regulator AsnC NP_828063.1 8219620 D 227882 CDS NP_828064.1 29833430 1217129 complement(8220069..8220266) 1 NC_003155.4 hypothetical protein 8220266 1217129 SAV_6888 Streptomyces avermitilis MA-4680 hypothetical protein NP_828064.1 8220069 R 227882 CDS NP_828065.1 29833431 1217130 8220462..8222939 1 NC_003155.4 sensor-like histidine kinase 8222939 1217130 SAV_6889 Streptomyces avermitilis MA-4680 sensor-like histidine kinase NP_828065.1 8220462 D 227882 CDS NP_828066.1 29833432 1217131 8222929..8223468 1 NC_003155.4 PF03259: Roadblock/LC7 domain; hypothetical protein 8223468 1217131 SAV_6890 Streptomyces avermitilis MA-4680 hypothetical protein NP_828066.1 8222929 D 227882 CDS NP_828067.1 29833433 1217132 8223476..8223853 1 NC_003155.4 PF05331: Protein of unknown function (DUF742); hypothetical protein 8223853 1217132 SAV_6891 Streptomyces avermitilis MA-4680 hypothetical protein NP_828067.1 8223476 D 227882 CDS NP_828068.1 29833434 1217133 8224288..8225076 1 NC_003155.4 PF00795: Carbon-nitrogen hydrolase; hydrolase 8225076 1217133 SAV_6892 Streptomyces avermitilis MA-4680 hydrolase NP_828068.1 8224288 D 227882 CDS NP_828069.1 29833435 1217134 8225124..8226821 1 NC_003155.4 amino oxidase 8226821 1217134 SAV_6893 Streptomyces avermitilis MA-4680 amino oxidase NP_828069.1 8225124 D 227882 CDS NP_828070.1 29833436 1217135 complement(8226837..8227766) 1 NC_003155.4 PF00296: Luciferase-like monooxygenase; hypothetical protein 8227766 1217135 SAV_6894 Streptomyces avermitilis MA-4680 hypothetical protein NP_828070.1 8226837 R 227882 CDS NP_828071.1 29833437 1217136 complement(8227870..8228544) 1 NC_003155.4 hypothetical protein 8228544 1217136 SAV_6895 Streptomyces avermitilis MA-4680 hypothetical protein NP_828071.1 8227870 R 227882 CDS NP_828072.1 29833438 1211613 8228717..8229829 1 NC_003155.4 endo-1,4-beta-glucanase 8229829 celA5 1211613 celA5 Streptomyces avermitilis MA-4680 endo-1,4-beta-glucanase NP_828072.1 8228717 D 227882 CDS NP_828073.1 29833439 1211614 complement(8229811..8231250) 1 NC_003155.4 uracyl permease 8231250 pyrP 1211614 pyrP Streptomyces avermitilis MA-4680 uracyl permease NP_828073.1 8229811 R 227882 CDS NP_828074.1 29833440 1217137 8231372..8232637 1 NC_003155.4 hypothetical protein 8232637 1217137 SAV_6898 Streptomyces avermitilis MA-4680 hypothetical protein NP_828074.1 8231372 D 227882 CDS NP_828075.1 29833441 1217138 8232735..8233205 1 NC_003155.4 PF03061: Thioesterase superfamily; hypothetical protein 8233205 1217138 SAV_6899 Streptomyces avermitilis MA-4680 hypothetical protein NP_828075.1 8232735 D 227882 CDS NP_828076.1 29833442 1217139 complement(8233165..8234376) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; integral membrane transport protein 8234376 1217139 SAV_6900 Streptomyces avermitilis MA-4680 integral membrane transport protein NP_828076.1 8233165 R 227882 CDS NP_828077.1 29833443 1217140 8234502..8235689 1 NC_003155.4 transcriptional regulator 8235689 1217140 SAV_6901 Streptomyces avermitilis MA-4680 transcriptional regulator NP_828077.1 8234502 D 227882 CDS NP_828078.1 29833444 1211615 8236486..8237094 1 NC_003155.4 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 8237094 ribC 1211615 ribC Streptomyces avermitilis MA-4680 riboflavin synthase subunit alpha NP_828078.1 8236486 D 227882 CDS NP_828079.1 29833445 1217141 8237091..8237735 1 NC_003155.4 PF04973: Nicotinamide mononucleotide transporter; integral membrane protein 8237735 1217141 SAV_6903 Streptomyces avermitilis MA-4680 integral membrane protein NP_828079.1 8237091 D 227882 CDS NP_828080.1 29833446 1211616 8237732..8239021 1 NC_003155.4 bifunctional enzyme DHBP synthase/GTP cyclohydrolase II; functions in riboflavin synthesis; converts GTP to 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine; converts ribulose 5-phopshate to 3,4-dihydroxy-2-butanone 4-phosphate; bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein 8239021 ribA1 1211616 ribA1 Streptomyces avermitilis MA-4680 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein NP_828080.1 8237732 D 227882 CDS NP_828081.1 29833447 1211617 8239041..8239526 1 NC_003155.4 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 8239526 ribH 1211617 ribH Streptomyces avermitilis MA-4680 6,7-dimethyl-8-ribityllumazine synthase NP_828081.1 8239041 D 227882 CDS NP_828082.1 29833448 1211618 8239561..8239833 1 NC_003155.4 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis; phosphoribosyl-ATP pyrophosphatase 8239833 hisE 1211618 hisE Streptomyces avermitilis MA-4680 phosphoribosyl-ATP pyrophosphatase NP_828082.1 8239561 D 227882 CDS NP_828083.1 29833449 1211619 8239883..8240740 1 NC_003155.4 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 8240740 hisG 1211619 hisG Streptomyces avermitilis MA-4680 ATP phosphoribosyltransferase NP_828083.1 8239883 D 227882 CDS NP_828084.1 29833450 1217142 8240755..8241219 1 NC_003155.4 hypothetical protein 8241219 1217142 SAV_6908 Streptomyces avermitilis MA-4680 hypothetical protein NP_828084.1 8240755 D 227882 CDS NP_828085.1 29833451 1217143 8241446..8242867 1 NC_003155.4 PF01595: Domain of unknown function DUF21, PF03471: Transporter associated domain, PF00571: CBS domain; integral membrane protein 8242867 1217143 SAV_6909 Streptomyces avermitilis MA-4680 integral membrane protein NP_828085.1 8241446 D 227882 CDS NP_828086.1 29833452 1217144 8242864..8243958 1 NC_003155.4 PF01595: Domain of unknown function DUF21; integral membrane protein 8243958 1217144 SAV_6910 Streptomyces avermitilis MA-4680 integral membrane protein NP_828086.1 8242864 D 227882 CDS NP_828087.1 29833453 1217145 complement(8244005..8245867) 1 NC_003155.4 PF00004: ATPase family associated with various cellular activities (AAA); ATPase 8245867 1217145 SAV_6911 Streptomyces avermitilis MA-4680 ATPase NP_828087.1 8244005 R 227882 CDS NP_828088.1 29833454 1217146 complement(8246299..8246952) 1 NC_003155.4 PF00485: Phosphoribulokinase / Uridine kinase family; hypothetical protein 8246952 1217146 SAV_6912 Streptomyces avermitilis MA-4680 hypothetical protein NP_828088.1 8246299 R 227882 CDS NP_828089.1 29833455 1217147 8247166..8248164 1 NC_003155.4 hypothetical protein 8248164 1217147 SAV_6913 Streptomyces avermitilis MA-4680 hypothetical protein NP_828089.1 8247166 D 227882 CDS NP_828090.1 29833456 1217148 8248213..8249763 1 NC_003155.4 amino acid permease 8249763 1217148 SAV_6914 Streptomyces avermitilis MA-4680 amino acid permease NP_828090.1 8248213 D 227882 CDS NP_828091.1 29833457 1217149 8249962..8251314 1 NC_003155.4 hypothetical protein 8251314 1217149 SAV_6915 Streptomyces avermitilis MA-4680 hypothetical protein NP_828091.1 8249962 D 227882 CDS NP_828092.1 29833458 1217150 8251453..8251593 1 NC_003155.4 hypothetical protein 8251593 1217150 SAV_6916 Streptomyces avermitilis MA-4680 hypothetical protein NP_828092.1 8251453 D 227882 CDS NP_828093.1 29833459 1217151 8251721..8252380 1 NC_003155.4 TetR family transcriptional regulator 8252380 1217151 SAV_6917 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_828093.1 8251721 D 227882 CDS NP_828094.1 29833460 1211620 complement(8252433..8253716) 1 NC_003155.4 chitinase 8253716 chiD 1211620 chiD Streptomyces avermitilis MA-4680 chitinase NP_828094.1 8252433 R 227882 CDS NP_828095.1 29833461 1211621 8254072..8255244 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 8255244 fadE2 1211621 fadE2 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_828095.1 8254072 D 227882 CDS NP_828096.1 29833462 1217152 complement(8256320..8256748) 1 NC_003155.4 hypothetical protein 8256748 1217152 SAV_6920 Streptomyces avermitilis MA-4680 hypothetical protein NP_828096.1 8256320 R 227882 CDS NP_828097.1 29833463 1217153 8256960..8257457 1 NC_003155.4 transcription regulator AsnC 8257457 1217153 SAV_6921 Streptomyces avermitilis MA-4680 transcription regulator AsnC NP_828097.1 8256960 D 227882 CDS NP_828098.1 29833464 1217154 8257505..8259127 1 NC_003155.4 hypothetical protein 8259127 1217154 SAV_6922 Streptomyces avermitilis MA-4680 hypothetical protein NP_828098.1 8257505 D 227882 CDS NP_828099.1 29833465 1217155 8259737..8260534 1 NC_003155.4 PF00535: Glycosyl transferase; glycosyl transferase 8260534 1217155 SAV_6923 Streptomyces avermitilis MA-4680 glycosyl transferase NP_828099.1 8259737 D 227882 CDS NP_828100.1 29833466 1217156 8260622..8261194 1 NC_003155.4 PF04186: FxsA cytoplasmic membrane protein; hypothetical protein 8261194 1217156 SAV_6924 Streptomyces avermitilis MA-4680 hypothetical protein NP_828100.1 8260622 D 227882 CDS NP_828101.1 29833467 1217157 complement(8261372..8261746) 1 NC_003155.4 hypothetical protein 8261746 1217157 SAV_6925 Streptomyces avermitilis MA-4680 hypothetical protein NP_828101.1 8261372 R 227882 CDS NP_828102.1 29833468 1217158 complement(8262014..8263360) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 8263360 1217158 SAV_6926 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_828102.1 8262014 R 227882 CDS NP_828103.1 29833469 1211622 complement(8263401..8264168) 1 NC_003155.4 glycerophosphoryl diester phosphodiesterase 8264168 glpQ4 1211622 glpQ4 Streptomyces avermitilis MA-4680 glycerophosphoryl diester phosphodiesterase NP_828103.1 8263401 R 227882 CDS NP_828104.1 29833470 1217159 complement(8264165..8264932) 1 NC_003155.4 PF02588: Uncharacterized BCR, YitT family COG1284; hypothetical protein 8264932 1217159 SAV_6929 Streptomyces avermitilis MA-4680 hypothetical protein NP_828104.1 8264165 R 227882 CDS NP_828105.1 29833471 1217160 8264931..8266430 1 NC_003155.4 similar to PdxR involved in regulation of pyridoxal phosphate; GntR family transcriptional regulator 8266430 1217160 SAV_6928 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_828105.1 8264931 D 227882 CDS NP_828106.1 29833472 1217161 complement(8266448..8268115) 1 NC_003155.4 PF01580: FtsK/SpoIIIE family; hypothetical protein 8268115 1217161 SAV_6930 Streptomyces avermitilis MA-4680 hypothetical protein NP_828106.1 8266448 R 227882 CDS NP_828107.1 29833473 1217162 complement(8268153..8268347) 1 NC_003155.4 hypothetical protein 8268347 1217162 SAV_6931 Streptomyces avermitilis MA-4680 hypothetical protein NP_828107.1 8268153 R 227882 CDS NP_828108.1 29833474 1217163 8268640..8269044 1 NC_003155.4 PF00023: Ankyrin repeat; ankyrin-like protein 8269044 1217163 SAV_6932 Streptomyces avermitilis MA-4680 ankyrin-like protein NP_828108.1 8268640 D 227882 CDS NP_828109.1 29833475 1217164 8269346..8270764 1 NC_003155.4 hypothetical protein 8270764 1217164 SAV_6933 Streptomyces avermitilis MA-4680 hypothetical protein NP_828109.1 8269346 D 227882 CDS NP_828110.1 29833476 1217165 8270944..8272107 1 NC_003155.4 PF00534: Glycosyl transferases group 1; glycosyl transferase 8272107 1217165 SAV_6934 Streptomyces avermitilis MA-4680 glycosyl transferase NP_828110.1 8270944 D 227882 CDS NP_828111.1 29833477 1217166 8272104..8273312 1 NC_003155.4 PF00534: Glycosyl transferases group 1; glycosyl transferase 8273312 1217166 SAV_6935 Streptomyces avermitilis MA-4680 glycosyl transferase NP_828111.1 8272104 D 227882 CDS NP_828112.1 29833478 1217167 8273309..8274163 1 NC_003155.4 PF00657: GDSL-like Lipase/Acylhydrolase; hypothetical protein 8274163 1217167 SAV_6936 Streptomyces avermitilis MA-4680 hypothetical protein NP_828112.1 8273309 D 227882 CDS NP_828113.1 29833479 1211623 complement(8274168..8275037) 1 NC_003155.4 antagonist of KipI 8275037 kipA 1211623 kipA Streptomyces avermitilis MA-4680 antagonist of KipI NP_828113.1 8274168 R 227882 CDS NP_828114.1 29833480 1211624 complement(8275034..8275651) 1 NC_003155.4 inhibitor of KinA 8275651 kipI 1211624 kipI Streptomyces avermitilis MA-4680 inhibitor of KinA NP_828114.1 8275034 R 227882 CDS NP_828115.1 29833481 1217168 complement(8275648..8276400) 1 NC_003155.4 LamB/YcsF family protein 8276400 1217168 SAV_6939 Streptomyces avermitilis MA-4680 LamB/YcsF family protein NP_828115.1 8275648 R 227882 CDS NP_828116.1 29833482 1217169 complement(8276413..8277237) 1 NC_003155.4 PF07286: Protein of unknown function (DUF1445); hypothetical protein 8277237 1217169 SAV_6940 Streptomyces avermitilis MA-4680 hypothetical protein NP_828116.1 8276413 R 227882 CDS NP_828117.1 29833483 1217170 complement(8277234..8278553) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 8278553 1217170 SAV_6941 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_828117.1 8277234 R 227882 CDS NP_828118.1 29833484 1217171 8278809..8279510 1 NC_003155.4 GntR family transcriptional regulator 8279510 1217171 SAV_6942 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_828118.1 8278809 D 227882 CDS NP_828119.1 29833485 1217172 8279643..8281160 1 NC_003155.4 hypothetical protein 8281160 1217172 SAV_6943 Streptomyces avermitilis MA-4680 hypothetical protein NP_828119.1 8279643 D 227882 CDS NP_828120.1 29833486 1217173 8281255..8282133 1 NC_003155.4 hypothetical protein 8282133 1217173 SAV_6944 Streptomyces avermitilis MA-4680 hypothetical protein NP_828120.1 8281255 D 227882 CDS NP_828121.1 29833487 1217174 8282203..8286903 1 NC_003155.4 PF01576: Myosin tail; hypothetical protein 8286903 1217174 SAV_6945 Streptomyces avermitilis MA-4680 hypothetical protein NP_828121.1 8282203 D 227882 CDS NP_828122.1 29833488 1217175 complement(8286990..8288540) 1 NC_003155.4 PF00732: GMC oxidoreductase; choline oxidase 8288540 1217175 SAV_6946 Streptomyces avermitilis MA-4680 choline oxidase NP_828122.1 8286990 R 227882 CDS NP_828123.1 29833489 1217176 complement(8288644..8290212) 1 NC_003155.4 amino acid permease 8290212 1217176 SAV_6947 Streptomyces avermitilis MA-4680 amino acid permease NP_828123.1 8288644 R 227882 CDS NP_828124.1 29833490 1211625 complement(8290309..8291832) 1 NC_003155.4 glycine betaine aldehyde dehydrogenase 8291832 gbsA3 1211625 gbsA3 Streptomyces avermitilis MA-4680 glycine betaine aldehyde dehydrogenase NP_828124.1 8290309 R 227882 CDS NP_828125.1 29833491 1217177 complement(8291796..8292944) 1 NC_003155.4 PF00355: Rieske [2Fe-2S] domain; ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenase 8292944 1217177 SAV_6949 Streptomyces avermitilis MA-4680 ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenase NP_828125.1 8291796 R 227882 CDS NP_828126.1 29833492 1211626 complement(8292956..8294110) 1 NC_003155.4 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase 8294110 solA 1211626 solA Streptomyces avermitilis MA-4680 N-methyltryptophan oxidase NP_828126.1 8292956 R 227882 CDS NP_828127.1 29833493 1217178 complement(8294120..8296576) 1 NC_003155.4 PF01571: Glycine cleavage T-protein (aminomethyl transferase); sarcosine dehydrogenase 8296576 1217178 SAV_6951 Streptomyces avermitilis MA-4680 sarcosine dehydrogenase NP_828127.1 8294120 R 227882 CDS NP_828128.1 29833494 1211627 complement(8296623..8297249) 1 NC_003155.4 PF00753: Metallo-beta-lactamase superfamily; metallo-beta-lactamase 8297249 blaB4 1211627 blaB4 Streptomyces avermitilis MA-4680 metallo-beta-lactamase NP_828128.1 8296623 R 227882 CDS NP_828129.1 29833495 1217179 complement(8297246..8298337) 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; alcohol dehydrogenase 8298337 adhA10 1217179 adhA10 Streptomyces avermitilis MA-4680 alcohol dehydrogenase NP_828129.1 8297246 R 227882 CDS NP_828130.1 29833496 1217180 complement(8298618..8299448) 1 NC_003155.4 IclR family transcriptional regulator 8299448 1217180 SAV_6954 Streptomyces avermitilis MA-4680 IclR family transcriptional regulator NP_828130.1 8298618 R 227882 CDS NP_828131.1 29833497 1217181 8299712..8300032 1 NC_003155.4 3-phenylpropionate dioxygenase ferredoxin subunit 8300032 hcaC2 1217181 hcaC2 Streptomyces avermitilis MA-4680 3-phenylpropionate dioxygenase ferredoxin subunit NP_828131.1 8299712 D 227882 CDS NP_828132.1 29833498 1211628 8300184..8301425 1 NC_003155.4 ferredoxin reductase 8301425 fprF 1211628 fprF Streptomyces avermitilis MA-4680 ferredoxin reductase NP_828132.1 8300184 D 227882 CDS NP_828133.1 29833499 1217182 complement(8301571..8302188) 1 NC_003155.4 hypothetical protein 8302188 1217182 SAV_6957 Streptomyces avermitilis MA-4680 hypothetical protein NP_828133.1 8301571 R 227882 CDS NP_828134.1 29833500 1211629 8302609..8305449 1 NC_003155.4 multi-component regulatory system-11; sensor-like histidine kinase 8305449 cvnA11 1211629 cvnA11 Streptomyces avermitilis MA-4680 sensor-like histidine kinase NP_828134.1 8302609 D 227882 CDS NP_828135.1 29833501 1211630 8305446..8305886 1 NC_003155.4 multi-component regulatory system-11, PF03259: Roadblock/LC7 domain; hypothetical protein 8305886 cvnB11 1211630 cvnB11 Streptomyces avermitilis MA-4680 hypothetical protein NP_828135.1 8305446 D 227882 CDS NP_828136.1 29833502 1211631 8305896..8306291 1 NC_003155.4 multi-component regulatory system-11, PF05331: Protein of unknown function (DUF742); hypothetical protein 8306291 cvnC11 1211631 cvnC11 Streptomyces avermitilis MA-4680 hypothetical protein NP_828136.1 8305896 D 227882 CDS NP_828137.1 29833503 1217183 8306316..8309930 1 NC_003155.4 PF02538: Hydantoinase B/oxoprolinase; hydantoinase/oxoprolinase 8309930 1217183 SAV_6961 Streptomyces avermitilis MA-4680 hydantoinase/oxoprolinase NP_828137.1 8306316 D 227882 CDS NP_828138.1 29833504 1211632 8309911..8310516 1 NC_003155.4 multi-component regulatory system-11; ATP/GTP-binding protein 8310516 cvnD11 1211632 cvnD11 Streptomyces avermitilis MA-4680 ATP/GTP-binding protein NP_828138.1 8309911 D 227882 CDS NP_828139.1 29833505 1211633 complement(8310646..8312169) 1 NC_003155.4 glycerol kinase 8312169 glpK2 1211633 glpK2 Streptomyces avermitilis MA-4680 glycerol kinase NP_828139.1 8310646 R 227882 CDS NP_828140.1 29833506 1217184 complement(8312188..8312937) 1 NC_003155.4 glycerol uptake facilitator protein 8312937 glpF2 1217184 glpF2 Streptomyces avermitilis MA-4680 glycerol uptake facilitator protein NP_828140.1 8312188 R 227882 CDS NP_828141.1 29833507 1217185 complement(8313344..8314969) 1 NC_003155.4 PF00563: EAL domain; hypothetical protein 8314969 1217185 SAV_6965 Streptomyces avermitilis MA-4680 hypothetical protein NP_828141.1 8313344 R 227882 CDS NP_828142.1 29833508 1217186 complement(8315096..8316286) 1 NC_003155.4 PF00108: Thiolase, N-terminal domain; lipid-transfer protein 8316286 1217186 SAV_6966 Streptomyces avermitilis MA-4680 lipid-transfer protein NP_828142.1 8315096 R 227882 CDS NP_828143.1 29833509 1217187 complement(8316283..8316729) 1 NC_003155.4 PF01796: Domain of unknown function DUF35; hypothetical protein 8316729 1217187 SAV_6967 Streptomyces avermitilis MA-4680 hypothetical protein NP_828143.1 8316283 R 227882 CDS NP_828144.1 29833510 1217188 8316959..8317495 1 NC_003155.4 Nudix/MutT family protein 8317495 1217188 SAV_6968 Streptomyces avermitilis MA-4680 Nudix/MutT family protein NP_828144.1 8316959 D 227882 CDS NP_828145.1 29833511 1217189 complement(8317535..8319901) 1 NC_003155.4 PF01055: Glycosyl hydrolases family 31; glycosyl hydrolase 8319901 1217189 SAV_6969 Streptomyces avermitilis MA-4680 glycosyl hydrolase NP_828145.1 8317535 R 227882 CDS NP_828146.1 29833512 1211634 8320115..8322082 1 NC_003155.4 AcsA; in Sinorhizobium meliloti this enzyme is required for acetoacetate activation; similar to acetyl-CoA synthase; acetoacetyl-CoA synthetase 8322082 acsA2 1211634 acsA2 Streptomyces avermitilis MA-4680 acetoacetyl-CoA synthetase NP_828146.1 8320115 D 227882 CDS NP_828147.1 29833513 1217190 complement(8322083..8323402) 1 NC_003155.4 GntR family transcriptional regulator 8323402 1217190 SAV_6971 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_828147.1 8322083 R 227882 CDS NP_828148.1 29833514 1217191 8323448..8324722 1 NC_003155.4 PF07690: Major Facilitator Superfamily; membrane transport protein 8324722 1217191 SAV_6972 Streptomyces avermitilis MA-4680 membrane transport protein NP_828148.1 8323448 D 227882 CDS NP_828149.1 29833515 1217192 8324745..8325638 1 NC_003155.4 hypothetical protein 8325638 1217192 SAV_6973 Streptomyces avermitilis MA-4680 hypothetical protein NP_828149.1 8324745 D 227882 CDS NP_828150.1 29833516 1211635 complement(8325726..8327396) 1 NC_003155.4 PF02896: PEP-utilising enzyme, TIM barrel domain; phosphoenolpyruvate-protein phosphotransferase 8327396 ptsP 1211635 ptsP Streptomyces avermitilis MA-4680 phosphoenolpyruvate-protein phosphotransferase NP_828150.1 8325726 R 227882 CDS NP_828151.1 29833517 1211636 complement(8327473..8327922) 1 NC_003155.4 PF00358: phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1; phosphoenolpyruvate-dependent sugar phosphotransferase 8327922 ptsA 1211636 ptsA Streptomyces avermitilis MA-4680 phosphoenolpyruvate-dependent sugar phosphotransferase NP_828151.1 8327473 R 227882 CDS NP_828152.1 29833518 1211640 8333915..8334523 1 NC_003155.4 CDP-diacylglycerol--glycerol-3- phosphate 3-phosphatidyl-transferase 8334523 pgsA3 1211640 pgsA3 Streptomyces avermitilis MA-4680 CDP-diacylglycerol--glycerol-3- phosphate 3-phosphatidyl-transferase NP_828152.1 8333915 D 227882 CDS NP_828153.1 29833519 1211641 8334639..8337134 1 NC_003155.4 mannose-1-phosphate guanyltransferase 8337134 mpg3 1211641 mpg3 Streptomyces avermitilis MA-4680 mannose-1-phosphate guanyltransferase NP_828153.1 8334639 D 227882 CDS NP_828154.1 29833520 1217193 8337225..8338130 1 NC_003155.4 PF05949: Bacterial protein of unknown function (DUF881); hypothetical protein 8338130 1217193 SAV_6978 Streptomyces avermitilis MA-4680 hypothetical protein NP_828154.1 8337225 D 227882 CDS NP_828155.1 29833521 1217194 8338127..8338459 1 NC_003155.4 PF06947: Protein of unknown function (DUF1290); hypothetical protein 8338459 1217194 SAV_6979 Streptomyces avermitilis MA-4680 hypothetical protein NP_828155.1 8338127 D 227882 CDS NP_828156.1 29833522 1217195 8338456..8339331 1 NC_003155.4 PF05949: Bacterial protein of unknown function (DUF881); hypothetical protein 8339331 1217195 SAV_6980 Streptomyces avermitilis MA-4680 hypothetical protein NP_828156.1 8338456 D 227882 CDS NP_828157.1 29833523 1217196 8339393..8340367 1 NC_003155.4 PF00498: FHA domain; hypothetical protein 8340367 1217196 SAV_6981 Streptomyces avermitilis MA-4680 hypothetical protein NP_828157.1 8339393 D 227882 CDS NP_828158.1 29833524 1217197 8340386..8341141 1 NC_003155.4 PF00376: MerR family regulatory protein; hypothetical protein 8341141 1217197 SAV_6982 Streptomyces avermitilis MA-4680 hypothetical protein NP_828158.1 8340386 D 227882 CDS NP_828159.1 29833525 1217198 8341228..8341701 1 NC_003155.4 PF02577: Uncharacterised ACR, COG1259; hypothetical protein 8341701 1217198 SAV_6983 Streptomyces avermitilis MA-4680 hypothetical protein NP_828159.1 8341228 D 227882 CDS NP_828160.1 29833526 1217199 8341986..8342621 1 NC_003155.4 hypothetical protein 8342621 1217199 SAV_6984 Streptomyces avermitilis MA-4680 hypothetical protein NP_828160.1 8341986 D 227882 CDS NP_828161.1 29833527 1211642 8342842..8344551 1 NC_003155.4 Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits; DNA polymerase IV 8344551 dinB 1211642 dinB Streptomyces avermitilis MA-4680 DNA polymerase IV NP_828161.1 8342842 D 227882 CDS NP_828162.1 29833528 1217200 complement(8344473..8344895) 1 NC_003155.4 PF05239: PRC-barrel domain; hypothetical protein 8344895 1217200 SAV_6986 Streptomyces avermitilis MA-4680 hypothetical protein NP_828162.1 8344473 R 227882 CDS NP_828163.1 29833529 1211643 8345154..8348117 1 NC_003155.4 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 8348117 gcvB 1211643 gcvB Streptomyces avermitilis MA-4680 glycine dehydrogenase NP_828163.1 8345154 D 227882 CDS NP_828164.1 29833530 1217201 complement(8348288..8348494) 1 NC_003155.4 hypothetical protein 8348494 1217201 SAV_6988 Streptomyces avermitilis MA-4680 hypothetical protein NP_828164.1 8348288 R 227882 CDS NP_828165.1 29833531 1217202 complement(8348882..8349466) 1 NC_003155.4 hypothetical protein 8349466 1217202 SAV_6989 Streptomyces avermitilis MA-4680 hypothetical protein NP_828165.1 8348882 R 227882 CDS NP_828166.1 29833532 1217203 8349837..8351522 1 NC_003155.4 PF04107: Glutamate-cysteine ligase family 2(GCS2); hypothetical protein 8351522 1217203 SAV_6990 Streptomyces avermitilis MA-4680 hypothetical protein NP_828166.1 8349837 D 227882 CDS NP_828167.1 29833533 1217204 complement(8351630..8353501) 1 NC_003155.4 PF00092: von Willebrand factor type A domain; hypothetical protein 8353501 1217204 SAV_6991 Streptomyces avermitilis MA-4680 hypothetical protein NP_828167.1 8351630 R 227882 CDS NP_828168.1 29833534 1217205 8353578..8354378 1 NC_003155.4 PF02517: CAAX amino terminal protease family; hypothetical protein 8354378 1217205 SAV_6992 Streptomyces avermitilis MA-4680 hypothetical protein NP_828168.1 8353578 D 227882 CDS NP_828169.1 29833535 1217206 complement(8354368..8355186) 1 NC_003155.4 PF02567: Phenazine biosynthesis-like protein; phenazine biosynthesis protein 8355186 phzC 1217206 phzC Streptomyces avermitilis MA-4680 phenazine biosynthesis protein NP_828169.1 8354368 R 227882 CDS NP_828170.1 29833536 1217207 8355594..8356247 1 NC_003155.4 PadR-like family transcriptional regulator 8356247 1217207 SAV_6994 Streptomyces avermitilis MA-4680 PadR-like family transcriptional regulator NP_828170.1 8355594 D 227882 CDS NP_828171.1 29833537 1217208 complement(8356323..8356829) 1 NC_003155.4 PF03364: Streptomyces cyclase/dehydrase; hypothetical protein 8356829 1217208 SAV_6995 Streptomyces avermitilis MA-4680 hypothetical protein NP_828171.1 8356323 R 227882 CDS NP_828172.1 29833538 1217209 8356906..8357658 1 NC_003155.4 PF02861: Clp amino terminal domain; hypothetical protein 8357658 1217209 SAV_6996 Streptomyces avermitilis MA-4680 hypothetical protein NP_828172.1 8356906 D 227882 CDS NP_828173.1 29833539 1217210 8357775..8358782 1 NC_003155.4 PF00892: Integral membrane protein DUF6; hypothetical protein 8358782 1217210 SAV_6997 Streptomyces avermitilis MA-4680 hypothetical protein NP_828173.1 8357775 D 227882 CDS NP_828174.1 29833540 1217211 8359004..8359996 1 NC_003155.4 PF00892: Integral membrane protein DUF6; hypothetical protein 8359996 1217211 SAV_6998 Streptomyces avermitilis MA-4680 hypothetical protein NP_828174.1 8359004 D 227882 CDS NP_828175.1 29833541 1217212 complement(8360388..8361089) 1 NC_003155.4 hypothetical protein 8361089 1217212 SAV_6999 Streptomyces avermitilis MA-4680 hypothetical protein NP_828175.1 8360388 R 227882 CDS NP_828176.1 29833542 1217213 8361113..8362444 1 NC_003155.4 GntR family transcriptional regulator 8362444 1217213 SAV_7000 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_828176.1 8361113 D 227882 CDS NP_828177.1 29833543 1217214 complement(8362446..8363381) 1 NC_003155.4 PF00892: Integral membrane protein DUF6; hypothetical protein 8363381 1217214 SAV_7001 Streptomyces avermitilis MA-4680 hypothetical protein NP_828177.1 8362446 R 227882 CDS NP_828178.1 29833544 1217215 8363460..8364359 1 NC_003155.4 LysR family transcriptional regulator 8364359 1217215 SAV_7002 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_828178.1 8363460 D 227882 CDS NP_828179.1 29833545 1217216 complement(8364506..8364973) 1 NC_003155.4 PF01243: Pyridoxamine 5'-phosphate oxidase; hypothetical protein 8364973 1217216 SAV_7003 Streptomyces avermitilis MA-4680 hypothetical protein NP_828179.1 8364506 R 227882 CDS NP_828180.1 29833546 1217217 8365030..8365752 1 NC_003155.4 PF00857: Isochorismatase family; hypothetical protein 8365752 1217217 SAV_7004 Streptomyces avermitilis MA-4680 hypothetical protein NP_828180.1 8365030 D 227882 CDS NP_828181.1 29833547 1217218 complement(8365833..8366324) 1 NC_003155.4 iron sulphur protein 8366324 1217218 SAV_7005 Streptomyces avermitilis MA-4680 iron sulphur protein NP_828181.1 8365833 R 227882 CDS NP_828182.1 29833548 1217219 8366488..8367243 1 NC_003155.4 hypothetical protein 8367243 1217219 SAV_7006 Streptomyces avermitilis MA-4680 hypothetical protein NP_828182.1 8366488 D 227882 CDS NP_828183.1 29833549 1217220 8367240..8367623 1 NC_003155.4 hypothetical protein 8367623 1217220 SAV_7007 Streptomyces avermitilis MA-4680 hypothetical protein NP_828183.1 8367240 D 227882 CDS NP_828184.1 29833550 1211644 8367774..8368535 1 NC_003155.4 PF00106: short chain dehydrogenase; 3-oxoacyl-ACP reductase 8368535 fabG8 1211644 fabG8 Streptomyces avermitilis MA-4680 3-oxoacyl-ACP reductase NP_828184.1 8367774 D 227882 CDS NP_828185.1 29833551 1217221 8368553..8369314 1 NC_003155.4 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 8369314 fabG 1217221 fabG Streptomyces avermitilis MA-4680 3-ketoacyl-ACP reductase NP_828185.1 8368553 D 227882 CDS NP_828186.1 29833552 1217222 8369462..8371084 1 NC_003155.4 PF00496: Bacterial extracellular solute-binding proteins, family 5 Middle; lipoprotein oligopeptide binding protein 8371084 1217222 SAV_7010 Streptomyces avermitilis MA-4680 lipoprotein oligopeptide binding protein NP_828186.1 8369462 D 227882 CDS NP_828187.1 29833553 1211645 8371165..8371848 1 NC_003155.4 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 8371848 ung2 1211645 ung2 Streptomyces avermitilis MA-4680 uracil-DNA glycosylase NP_828187.1 8371165 D 227882 CDS NP_828188.1 29833554 1217223 8371980..8372630 1 NC_003155.4 hypothetical protein 8372630 1217223 SAV_7012 Streptomyces avermitilis MA-4680 hypothetical protein NP_828188.1 8371980 D 227882 CDS NP_828189.1 29833555 1217224 complement(8373001..8373465) 1 NC_003155.4 lipoprotein 8373465 1217224 SAV_7013 Streptomyces avermitilis MA-4680 lipoprotein NP_828189.1 8373001 R 227882 CDS NP_828190.1 29833556 1217225 complement(8373588..8374100) 1 NC_003155.4 PF04978: Protein of unknown function (DUF664); hypothetical protein 8374100 1217225 SAV_7014 Streptomyces avermitilis MA-4680 hypothetical protein NP_828190.1 8373588 R 227882 CDS NP_828191.1 29833557 1217226 8374210..8375115 1 NC_003155.4 PF01408: Oxidoreductase family, NAD-binding Rossmann fold; oxidoreductase 8375115 1217226 SAV_7015 Streptomyces avermitilis MA-4680 oxidoreductase NP_828191.1 8374210 D 227882 CDS NP_828192.1 29833558 1217227 complement(8375039..8376613) 1 NC_003155.4 PF00795: Carbon-nitrogen hydrolase; apolipoprotein N-acyltransferase 8376613 1217227 SAV_7016 Streptomyces avermitilis MA-4680 apolipoprotein N-acyltransferase NP_828192.1 8375039 R 227882 CDS NP_828193.1 29833559 1217228 complement(8376702..8377169) 1 NC_003155.4 hypothetical protein 8377169 1217228 SAV_7017 Streptomyces avermitilis MA-4680 hypothetical protein NP_828193.1 8376702 R 227882 CDS NP_828194.1 29833560 1217229 8377344..8378360 1 NC_003155.4 PF00296: Luciferase-like monooxygenase; monooxygenase 8378360 1217229 SAV_7018 Streptomyces avermitilis MA-4680 monooxygenase NP_828194.1 8377344 D 227882 CDS NP_828195.1 29833561 1217230 complement(8378431..8379291) 1 NC_003155.4 PF03631: Ribonuclease BN-like family; hypothetical protein 8379291 1217230 SAV_7019 Streptomyces avermitilis MA-4680 hypothetical protein NP_828195.1 8378431 R 227882 CDS NP_828196.1 29833562 1217231 complement(8379743..8380042) 1 NC_003155.4 hypothetical protein 8380042 1217231 SAV_7020 Streptomyces avermitilis MA-4680 hypothetical protein NP_828196.1 8379743 R 227882 CDS NP_828197.1 29833563 1217232 complement(8380573..8381448) 1 NC_003155.4 phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters UDP disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase 8381448 uppP 1217232 uppP Streptomyces avermitilis MA-4680 UDP pyrophosphate phosphatase NP_828197.1 8380573 R 227882 CDS NP_828198.1 29833564 1217233 8381768..8383210 1 NC_003155.4 PF01408: Oxidoreductase family, NAD-binding Rossmann fold; oxidoreductase 8383210 1217233 SAV_7022 Streptomyces avermitilis MA-4680 oxidoreductase NP_828198.1 8381768 D 227882 CDS NP_828199.1 29833565 1217234 8383207..8384142 1 NC_003155.4 hypothetical protein 8384142 1217234 SAV_7023 Streptomyces avermitilis MA-4680 hypothetical protein NP_828199.1 8383207 D 227882 CDS NP_828200.1 29833566 1217235 8384136..8384900 1 NC_003155.4 hypothetical protein 8384900 1217235 SAV_7024 Streptomyces avermitilis MA-4680 hypothetical protein NP_828200.1 8384136 D 227882 CDS NP_828201.1 29833567 1217236 complement(8384977..8385447) 1 NC_003155.4 transcriptional regulator 8385447 1217236 SAV_7025 Streptomyces avermitilis MA-4680 transcriptional regulator NP_828201.1 8384977 R 227882 CDS NP_828202.1 29833568 1211646 8385638..8386807 1 NC_003155.4 PF00108: Thiolase, N-terminal domain; 3-ketoacyl-CoA thiolase 8386807 fadA6 1211646 fadA6 Streptomyces avermitilis MA-4680 3-ketoacyl-CoA thiolase NP_828202.1 8385638 D 227882 CDS NP_828203.1 29833569 1217237 complement(8386812..8387621) 1 NC_003155.4 PF00597: DedA family; hypothetical protein 8387621 1217237 SAV_7027 Streptomyces avermitilis MA-4680 hypothetical protein NP_828203.1 8386812 R 227882 CDS NP_828204.1 29833570 1211647 8388106..8389278 1 NC_003155.4 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 8389278 tuf2 1211647 tuf2 Streptomyces avermitilis MA-4680 elongation factor Tu NP_828204.1 8388106 D 227882 CDS NP_828205.1 29833571 1217238 8389436..8390281 1 NC_003155.4 hypothetical protein 8390281 1217238 SAV_7029 Streptomyces avermitilis MA-4680 hypothetical protein NP_828205.1 8389436 D 227882 CDS NP_828206.1 29833572 1217239 complement(8390243..8391586) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 8391586 1217239 SAV_7030 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_828206.1 8390243 R 227882 CDS NP_828207.1 29833573 1217240 complement(8391768..8392808) 1 NC_003155.4 hypothetical protein 8392808 1217240 SAV_7031 Streptomyces avermitilis MA-4680 hypothetical protein NP_828207.1 8391768 R 227882 CDS NP_828208.1 29833574 1217241 complement(8392875..8393843) 1 NC_003155.4 hypothetical protein 8393843 1217241 SAV_7032 Streptomyces avermitilis MA-4680 hypothetical protein NP_828208.1 8392875 R 227882 CDS NP_828209.1 29833575 1217242 8393930..8394367 1 NC_003155.4 hypothetical protein 8394367 1217242 SAV_7033 Streptomyces avermitilis MA-4680 hypothetical protein NP_828209.1 8393930 D 227882 CDS NP_828210.1 29833576 1217243 complement(8394449..8394994) 1 NC_003155.4 PF05257: CHAP domain; hypothetical protein 8394994 1217243 SAV_7034 Streptomyces avermitilis MA-4680 hypothetical protein NP_828210.1 8394449 R 227882 CDS NP_828211.1 29833577 1217244 complement(8395028..8396659) 1 NC_003155.4 PF00474: Sodium:solute symporter family; sodium:solute symporter 8396659 1217244 SAV_7035 Streptomyces avermitilis MA-4680 sodium:solute symporter NP_828211.1 8395028 R 227882 CDS NP_828212.1 29833578 1217245 complement(8396656..8397066) 1 NC_003155.4 PF04341: Protein of unknown function, DUF485; hypothetical protein 8397066 1217245 SAV_7036 Streptomyces avermitilis MA-4680 hypothetical protein NP_828212.1 8396656 R 227882 CDS NP_828213.1 29833579 1217246 8397699..8398349 1 NC_003155.4 PF00597: DedA family; integral membrane protein 8398349 1217246 SAV_7037 Streptomyces avermitilis MA-4680 integral membrane protein NP_828213.1 8397699 D 227882 CDS NP_828214.1 29833580 1217247 complement(8398353..8398889) 1 NC_003155.4 PF00132: Bacterial transferase hexapeptide (three repeats); siderophore binding protein 8398889 1217247 SAV_7038 Streptomyces avermitilis MA-4680 siderophore binding protein NP_828214.1 8398353 R 227882 CDS NP_828215.1 29833581 1217248 8399056..8399820 1 NC_003155.4 PF00132: Bacterial transferase hexapeptide (three repeats); sugar acetyltransferase 8399820 1217248 SAV_7039 Streptomyces avermitilis MA-4680 sugar acetyltransferase NP_828215.1 8399056 D 227882 CDS NP_828216.1 29833582 1217249 complement(8399834..8400700) 1 NC_003155.4 PF00892: Integral membrane protein DUF6; hypothetical protein 8400700 1217249 SAV_7040 Streptomyces avermitilis MA-4680 hypothetical protein NP_828216.1 8399834 R 227882 CDS NP_828217.1 29833583 1217250 8400761..8401366 1 NC_003155.4 transcriptional regulatory protein 8401366 1217250 SAV_7041 Streptomyces avermitilis MA-4680 transcriptional regulatory protein NP_828217.1 8400761 D 227882 CDS NP_828218.1 29833584 1217251 8401410..8401964 1 NC_003155.4 PF04073: YbaK / prolyl-tRNA synthetases associated domain; hypothetical protein 8401964 1217251 SAV_7042 Streptomyces avermitilis MA-4680 hypothetical protein NP_828218.1 8401410 D 227882 CDS NP_828219.1 29833585 1217252 complement(8402020..8403195) 1 NC_003155.4 PF01545: Cation efflux family; cation efflux system protein 8403195 1217252 SAV_7043 Streptomyces avermitilis MA-4680 cation efflux system protein NP_828219.1 8402020 R 227882 CDS NP_828220.1 29833586 1217253 8403273..8403650 1 NC_003155.4 transcription regulator ArsR 8403650 1217253 SAV_7044 Streptomyces avermitilis MA-4680 transcription regulator ArsR NP_828220.1 8403273 D 227882 CDS NP_828221.1 29833587 1217254 complement(8403809..8404369) 1 NC_003155.4 reductase 8404369 1217254 SAV_7045 Streptomyces avermitilis MA-4680 reductase NP_828221.1 8403809 R 227882 CDS NP_828222.1 29833588 1217255 8404483..8405154 1 NC_003155.4 TetR family transcriptional regulator 8405154 1217255 SAV_7046 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_828222.1 8404483 D 227882 CDS NP_828223.1 29833589 1217256 8405182..8405733 1 NC_003155.4 PF04978: Protein of unknown function (DUF664); hypothetical protein 8405733 1217256 SAV_7047 Streptomyces avermitilis MA-4680 hypothetical protein NP_828223.1 8405182 D 227882 CDS NP_828224.1 29833590 1217257 8405794..8406909 1 NC_003155.4 PF01545: Cation efflux family; cation efflux system protein 8406909 1217257 SAV_7048 Streptomyces avermitilis MA-4680 cation efflux system protein NP_828224.1 8405794 D 227882 CDS NP_828225.1 29833591 1217258 complement(8407094..8407501) 1 NC_003155.4 PF02629: CoA binding domain; hypothetical protein 8407501 1217258 SAV_7049 Streptomyces avermitilis MA-4680 hypothetical protein NP_828225.1 8407094 R 227882 CDS NP_828226.1 29833592 1217259 8407591..8408403 1 NC_003155.4 hypothetical protein 8408403 1217259 SAV_7050 Streptomyces avermitilis MA-4680 hypothetical protein NP_828226.1 8407591 D 227882 CDS NP_828227.1 29833593 1217260 8408400..8408948 1 NC_003155.4 PF00300: Phosphoglycerate mutase family; hypothetical protein 8408948 1217260 SAV_7051 Streptomyces avermitilis MA-4680 hypothetical protein NP_828227.1 8408400 D 227882 CDS NP_828228.1 29833594 1217261 complement(8408996..8410972) 1 NC_003155.4 PF00324: Amino acid permease; amino acid transporter 8410972 1217261 SAV_7052 Streptomyces avermitilis MA-4680 amino acid transporter NP_828228.1 8408996 R 227882 CDS NP_828229.1 29833595 1217262 8411271..8411897 1 NC_003155.4 PF01205: Uncharacterized protein family UPF0029; hypothetical protein 8411897 1217262 SAV_7053 Streptomyces avermitilis MA-4680 hypothetical protein NP_828229.1 8411271 D 227882 CDS NP_828230.1 29833596 1217263 8412224..8413720 1 NC_003155.4 PF00270: DEAD/DEAH box helicase; ATP-dependent RNA helicase 8413720 1217263 SAV_7054 Streptomyces avermitilis MA-4680 ATP-dependent RNA helicase NP_828230.1 8412224 D 227882 CDS NP_828231.1 29833597 1211648 8413967..8415130 1 NC_003155.4 PF00149: Calcineurin-like phosphoesterase; exonuclease 8415130 sbcD 1211648 sbcD Streptomyces avermitilis MA-4680 exonuclease NP_828231.1 8413967 D 227882 CDS NP_828232.1 29833598 1211649 8415198..8418197 1 NC_003155.4 PF02463: RecF/RecN/SMC N terminal domain; exonuclease 8418197 sbcC 1211649 sbcC Streptomyces avermitilis MA-4680 exonuclease NP_828232.1 8415198 D 227882 CDS NP_828233.1 29833599 1217264 complement(8418216..8418662) 1 NC_003155.4 transcription regulator AsnC 8418662 1217264 SAV_7057 Streptomyces avermitilis MA-4680 transcription regulator AsnC NP_828233.1 8418216 R 227882 CDS NP_828234.1 29833600 1217265 8418709..8419395 1 NC_003155.4 PF00581: Rhodanese-like domain; hypothetical protein 8419395 1217265 SAV_7058 Streptomyces avermitilis MA-4680 hypothetical protein NP_828234.1 8418709 D 227882 CDS NP_828235.1 29833601 1217266 8419484..8419708 1 NC_003155.4 hypothetical protein 8419708 1217266 SAV_7059 Streptomyces avermitilis MA-4680 hypothetical protein NP_828235.1 8419484 D 227882 CDS NP_828236.1 29833602 1217267 complement(8419839..8421530) 1 NC_003155.4 PF05960: Bacterial protein of unknown function (DUF885); hypothetical protein 8421530 1217267 SAV_7060 Streptomyces avermitilis MA-4680 hypothetical protein NP_828236.1 8419839 R 227882 CDS NP_828237.1 29833603 1217268 complement(8421593..8422057) 1 NC_003155.4 transcription regulator AsnC 8422057 1217268 SAV_7061 Streptomyces avermitilis MA-4680 transcription regulator AsnC NP_828237.1 8421593 R 227882 CDS NP_828238.1 29833604 1211650 8422223..8423464 1 NC_003155.4 methionine gamma lyase 8423464 mgl 1211650 mgl Streptomyces avermitilis MA-4680 methionine gamma lyase NP_828238.1 8422223 D 227882 CDS NP_828239.1 29833605 1217269 complement(8423663..8425096) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; hypothetical protein 8425096 1217269 SAV_7063 Streptomyces avermitilis MA-4680 hypothetical protein NP_828239.1 8423663 R 227882 CDS NP_828240.1 29833606 1217270 complement(8425448..8427115) 1 NC_003155.4 alkaline phosphatase 8427115 phoD2 1217270 phoD2 Streptomyces avermitilis MA-4680 alkaline phosphatase NP_828240.1 8425448 R 227882 CDS NP_828241.1 29833607 1217271 complement(8427289..8428776) 1 NC_003155.4 GntR family transcriptional regulator 8428776 1217271 SAV_7065 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_828241.1 8427289 R 227882 CDS NP_828242.1 29833608 1217272 8428851..8430017 1 NC_003155.4 PF00892: Integral membrane protein DUF6; integral membrane protein 8430017 1217272 SAV_7066 Streptomyces avermitilis MA-4680 integral membrane protein NP_828242.1 8428851 D 227882 CDS NP_828243.1 29833609 1217273 complement(8429733..8430656) 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 8430656 1217273 SAV_7067 Streptomyces avermitilis MA-4680 hydrolase NP_828243.1 8429733 R 227882 CDS NP_828244.1 29833610 1211651 8430823..8431707 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 8431707 sig55 1211651 sig55 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_828244.1 8430823 D 227882 CDS NP_828245.1 29833611 1217274 8431958..8432719 1 NC_003155.4 GntR family transcriptional regulator 8432719 1217274 SAV_7069 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_828245.1 8431958 D 227882 CDS NP_828246.1 29833612 1217275 complement(8432946..8434103) 1 NC_003155.4 transcriptional regulator 8434103 1217275 SAV_7070 Streptomyces avermitilis MA-4680 transcriptional regulator NP_828246.1 8432946 R 227882 CDS NP_828247.1 29833613 1217276 complement(8434203..8434865) 1 NC_003155.4 two-component system response regulator 8434865 1217276 SAV_7071 Streptomyces avermitilis MA-4680 two-component system response regulator NP_828247.1 8434203 R 227882 CDS NP_828248.1 29833614 1217277 complement(8434880..8436058) 1 NC_003155.4 two-component system sensor kinase 8436058 1217277 SAV_7072 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_828248.1 8434880 R 227882 CDS NP_828249.1 29833615 1217278 8436167..8437093 1 NC_003155.4 ABC transporter ATP-binding protein 8437093 1217278 SAV_7073 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_828249.1 8436167 D 227882 CDS NP_828250.1 29833616 1217279 8437097..8437819 1 NC_003155.4 ABC transporter permease 8437819 1217279 SAV_7074 Streptomyces avermitilis MA-4680 ABC transporter permease NP_828250.1 8437097 D 227882 CDS NP_828251.1 29833617 1217280 8437877..8438317 1 NC_003155.4 hypothetical protein 8438317 1217280 SAV_7075 Streptomyces avermitilis MA-4680 hypothetical protein NP_828251.1 8437877 D 227882 CDS NP_828252.1 29833618 1211652 complement(8438343..8438783) 1 NC_003155.4 G/U mismatch-specific DNA glycosylase 8438783 mug 1211652 mug Streptomyces avermitilis MA-4680 G/U mismatch-specific DNA glycosylase NP_828252.1 8438343 R 227882 CDS NP_828253.1 29833619 1211653 complement(8438888..8440327) 1 NC_003155.4 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 8440327 purB 1211653 purB Streptomyces avermitilis MA-4680 adenylosuccinate lyase NP_828253.1 8438888 R 227882 CDS NP_828254.1 29833620 1217281 complement(8440387..8440737) 1 NC_003155.4 hypothetical protein 8440737 1217281 SAV_7078 Streptomyces avermitilis MA-4680 hypothetical protein NP_828254.1 8440387 R 227882 CDS NP_828255.1 29833621 1217282 complement(8440759..8441541) 1 NC_003155.4 PF00657: GDSL-like Lipase/Acylhydrolase; hypothetical protein 8441541 1217282 SAV_7079 Streptomyces avermitilis MA-4680 hypothetical protein NP_828255.1 8440759 R 227882 CDS NP_828256.1 29833622 1217283 complement(8441839..8442852) 1 NC_003155.4 PF01595: Domain of unknown function DUF21; integral membrane protein 8442852 1217283 SAV_7080 Streptomyces avermitilis MA-4680 integral membrane protein NP_828256.1 8441839 R 227882 CDS NP_828257.1 29833623 1217284 complement(8442849..8444195) 1 NC_003155.4 PF01595: Domain of unknown function DUF21; integral membrane protein 8444195 1217284 SAV_7081 Streptomyces avermitilis MA-4680 integral membrane protein NP_828257.1 8442849 R 227882 CDS NP_828258.1 29833624 1217285 complement(8444344..8444769) 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 8444769 1217285 SAV_7082 Streptomyces avermitilis MA-4680 acetyltransferase NP_828258.1 8444344 R 227882 CDS NP_828259.1 29833625 1217286 complement(8444891..8445781) 1 NC_003155.4 Rif11-like protein 8445781 1217286 SAV_7083 Streptomyces avermitilis MA-4680 Rif11-like protein NP_828259.1 8444891 R 227882 CDS NP_828260.1 29833626 1217287 complement(8445829..8448396) 1 NC_003155.4 ABC transporter permease 8448396 1217287 SAV_7084 Streptomyces avermitilis MA-4680 ABC transporter permease NP_828260.1 8445829 R 227882 CDS NP_828261.1 29833627 1217288 complement(8448408..8449292) 1 NC_003155.4 ABC transporter ATP-binding protein 8449292 1217288 SAV_7085 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_828261.1 8448408 R 227882 CDS NP_828262.1 29833628 1217289 8449521..8449760 1 NC_003155.4 hypothetical protein 8449760 1217289 SAV_7086 Streptomyces avermitilis MA-4680 hypothetical protein NP_828262.1 8449521 D 227882 CDS NP_828263.1 29833629 1217290 8449765..8450139 1 NC_003155.4 hypothetical protein 8450139 1217290 SAV_7087 Streptomyces avermitilis MA-4680 hypothetical protein NP_828263.1 8449765 D 227882 CDS NP_828264.1 29833630 1217291 complement(8450156..8450842) 1 NC_003155.4 PF01209: ubiE/COQ5 methyltransferase family; hypothetical protein 8450842 1217291 SAV_7088 Streptomyces avermitilis MA-4680 hypothetical protein NP_828264.1 8450156 R 227882 CDS NP_828265.1 29833631 1217292 complement(8450955..8451641) 1 NC_003155.4 lipase 8451641 lpsA1 1217292 lpsA1 Streptomyces avermitilis MA-4680 lipase NP_828265.1 8450955 R 227882 CDS NP_828266.1 29833632 1211654 8451756..8453981 1 NC_003155.4 lpsA1 transcriptional activator 8453981 lpsR 1211654 lpsR Streptomyces avermitilis MA-4680 lpsA1 transcriptional activator NP_828266.1 8451756 D 227882 CDS NP_828267.1 29833633 1211655 complement(8453985..8454701) 1 NC_003155.4 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 8454701 bioD 1211655 bioD Streptomyces avermitilis MA-4680 dithiobiotin synthetase NP_828267.1 8453985 R 227882 CDS NP_828268.1 29833634 1211656 complement(8454703..8456016) 1 NC_003155.4 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine--8-amino-7-oxononanoate transaminase 8456016 bioA 1211656 bioA Streptomyces avermitilis MA-4680 adenosylmethionine--8-amino-7-oxononanoate transaminase NP_828268.1 8454703 R 227882 CDS NP_828269.1 29833635 1211657 complement(8455985..8457151) 1 NC_003155.4 catalyzes the formation of biotin from dethiobiotin and sulfur 2 S-adenosyl-L-methionine; biotin synthase 8457151 bioB 1211657 bioB Streptomyces avermitilis MA-4680 biotin synthase NP_828269.1 8455985 R 227882 CDS NP_828270.1 29833636 1211658 8457312..8458469 1 NC_003155.4 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 8458469 bioF 1211658 bioF Streptomyces avermitilis MA-4680 8-amino-7-oxononanoate synthase NP_828270.1 8457312 D 227882 CDS NP_828271.1 29833637 1217293 complement(8458491..8458670) 1 NC_003155.4 PF04149: Domain of unknown function (DUF397); hypothetical protein 8458670 1217293 SAV_7095 Streptomyces avermitilis MA-4680 hypothetical protein NP_828271.1 8458491 R 227882 CDS NP_828272.1 29833638 1217294 complement(8458736..8459587) 1 NC_003155.4 DNA-binding protein 8459587 1217294 SAV_7096 Streptomyces avermitilis MA-4680 DNA-binding protein NP_828272.1 8458736 R 227882 CDS NP_828273.1 29833639 1217295 8459835..8460293 1 NC_003155.4 regulatory protein 8460293 1217295 SAV_7097 Streptomyces avermitilis MA-4680 regulatory protein NP_828273.1 8459835 D 227882 CDS NP_828274.1 29833640 1217296 complement(8460552..8461106) 1 NC_003155.4 hypothetical protein 8461106 1217296 SAV_7098 Streptomyces avermitilis MA-4680 hypothetical protein NP_828274.1 8460552 R 227882 CDS NP_828275.1 29833641 1217297 complement(8461155..8461628) 1 NC_003155.4 Seems to have no N-terminal signal sequence; NLP/P60-family protein 8461628 1217297 SAV_7099 Streptomyces avermitilis MA-4680 NLP/P60-family protein NP_828275.1 8461155 R 227882 CDS NP_828276.1 29833642 1217298 complement(8462164..8462472) 1 NC_003155.4 hypothetical protein 8462472 1217298 SAV_7100 Streptomyces avermitilis MA-4680 hypothetical protein NP_828276.1 8462164 R 227882 CDS NP_828277.1 29833643 1211659 complement(8462480..8463115) 1 NC_003155.4 PF00574: Clp protease; ATP-dependent Clp protease proteolytic subunit 2 8463115 clpP3 1211659 clpP3 Streptomyces avermitilis MA-4680 ATP-dependent Clp protease proteolytic subunit 2 NP_828277.1 8462480 R 227882 CDS NP_828278.1 29833644 1217299 8463350..8463625 1 NC_003155.4 PF02604: Phd_YefM; hypothetical protein 8463625 1217299 SAV_7102 Streptomyces avermitilis MA-4680 hypothetical protein NP_828278.1 8463350 D 227882 CDS NP_828279.1 29833645 1217300 8464059..8464340 1 NC_003155.4 hypothetical protein 8464340 1217300 SAV_7103 Streptomyces avermitilis MA-4680 hypothetical protein NP_828279.1 8464059 D 227882 CDS NP_828280.1 29833646 1211660 8464532..8464834 1 NC_003155.4 UreA, with UreB and UreC catalyzes the hydrolysis of urea into ammonia and carbon dioxide; nickel metalloenzyme; accessory proteins UreD, UreE, UreF, and UreG are necessary for assembly of the metallocenter; urease subunit gamma 8464834 ureA 1211660 ureA Streptomyces avermitilis MA-4680 urease subunit gamma NP_828280.1 8464532 D 227882 CDS NP_828281.1 29833647 1211661 8464852..8465163 1 NC_003155.4 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori and Yersinia enterocolitica the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 UreC (alpha) and 3 UreAB (gamma/beta); in Brucella suis the urease encoded by this operon (one of two urease-encoding operons found in its genome) is involved with urease activity, optimum growth, resistance to low-pH killing in-vitro and persistence in-vivo, while the other operon does not seem to be active; urease subunit beta 8465163 ureB 1211661 ureB Streptomyces avermitilis MA-4680 urease subunit beta NP_828281.1 8464852 D 227882 CDS NP_828282.1 29833648 1211662 8465156..8466877 1 NC_003155.4 ureases catalyze the hydrolysis of urea into ammonia and carbon dioxide; in Helicobacter pylori the ammonia released plays a key role in bacterial survival by neutralizing acids when colonizing the gastric mucosa; the holoenzyme is composed of 3 ureC (alpha) and 3 ureAB (gamma/beta) subunits; urease subunit alpha 8466877 ureC 1211662 ureC Streptomyces avermitilis MA-4680 urease subunit alpha NP_828282.1 8465156 D 227882 CDS NP_828283.1 29833649 1211663 8466877..8467551 1 NC_003155.4 PF01730: UreF; urease accessroy protein 8467551 ureF 1211663 ureF Streptomyces avermitilis MA-4680 urease accessroy protein NP_828283.1 8466877 D 227882 CDS NP_828284.1 29833650 1211664 8467570..8468253 1 NC_003155.4 PF02492: CobW/HypB/UreG, nucleotide-binding domain; urease accessory protein 8468253 ureG 1211664 ureG Streptomyces avermitilis MA-4680 urease accessory protein NP_828284.1 8467570 D 227882 CDS NP_828285.1 29833651 1211665 8468250..8469008 1 NC_003155.4 PF01774: UreD urease accessory protein; urease accessory protein 8469008 ureD 1211665 ureD Streptomyces avermitilis MA-4680 urease accessory protein NP_828285.1 8468250 D 227882 CDS NP_828286.1 29833652 1217301 8469147..8470742 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; tripeptidylaminopeptidase 8470742 1217301 SAV_7110 Streptomyces avermitilis MA-4680 tripeptidylaminopeptidase NP_828286.1 8469147 D 227882 CDS NP_828287.1 29833653 1211666 complement(8470813..8471538) 1 NC_003155.4 1-acylglycerol-3-phosphate O-acyltransferase 8471538 plsC6 1211666 plsC6 Streptomyces avermitilis MA-4680 1-acylglycerol-3-phosphate O-acyltransferase NP_828287.1 8470813 R 227882 CDS NP_828288.1 29833654 1211667 complement(8471639..8472865) 1 NC_003155.4 ornithine aminotransferase 8472865 rocD2 1211667 rocD2 Streptomyces avermitilis MA-4680 ornithine aminotransferase NP_828288.1 8471639 R 227882 CDS NP_828289.1 29833655 1217302 complement(8472862..8473731) 1 NC_003155.4 PF02274: Amidinotransferase; hypothetical protein 8473731 1217302 SAV_7113 Streptomyces avermitilis MA-4680 hypothetical protein NP_828289.1 8472862 R 227882 CDS NP_828290.1 29833656 1217303 complement(8473808..8474311) 1 NC_003155.4 transcription regulator AsnC 8474311 1217303 SAV_7114 Streptomyces avermitilis MA-4680 transcription regulator AsnC NP_828290.1 8473808 R 227882 CDS NP_828291.1 29833657 1217304 8474389..8475144 1 NC_003155.4 regulatory protein 8475144 1217304 SAV_7115 Streptomyces avermitilis MA-4680 regulatory protein NP_828291.1 8474389 D 227882 CDS NP_828292.1 29833658 1217305 8475158..8475517 1 NC_003155.4 hypothetical protein 8475517 1217305 SAV_7116 Streptomyces avermitilis MA-4680 hypothetical protein NP_828292.1 8475158 D 227882 CDS NP_828293.1 29833659 1217306 8475522..8477249 1 NC_003155.4 PF00474: Sodium:solute symporter family; transmembrane transport protein 8477249 1217306 SAV_7117 Streptomyces avermitilis MA-4680 transmembrane transport protein NP_828293.1 8475522 D 227882 CDS NP_828294.1 29833660 1211668 8477246..8478451 1 NC_003155.4 two-component system sensor kinase 8478451 lytS 1211668 lytS Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_828294.1 8477246 D 227882 CDS NP_828295.1 29833661 1217307 complement(8478645..8479382) 1 NC_003155.4 hypothetical protein 8479382 1217307 SAV_7119 Streptomyces avermitilis MA-4680 hypothetical protein NP_828295.1 8478645 R 227882 CDS NP_828296.1 29833662 1211669 complement(8478832..8480910) 1 NC_003155.4 serine/threonine protein kinase 8480910 pkn31 1211669 pkn31 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_828296.1 8478832 R 227882 CDS NP_828297.1 29833663 1217308 complement(8480924..8482384) 1 NC_003155.4 PF04554: Extensin-like region; hypothetical protein 8482384 1217308 SAV_7121 Streptomyces avermitilis MA-4680 hypothetical protein NP_828297.1 8480924 R 227882 CDS NP_828298.1 29833664 1217309 complement(8482495..8483448) 1 NC_003155.4 hypothetical protein 8483448 1217309 SAV_7122 Streptomyces avermitilis MA-4680 hypothetical protein NP_828298.1 8482495 R 227882 CDS NP_828299.1 29833665 1211670 complement(8483551..8484576) 1 NC_003155.4 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 8484576 pfkA3 1211670 pfkA3 Streptomyces avermitilis MA-4680 6-phosphofructokinase NP_828299.1 8483551 R 227882 CDS NP_828300.1 29833666 1217310 complement(8484766..8485494) 1 NC_003155.4 PF07685: CobB/CobQ-like glutamine amidotransferase domain; glutamine amidotransferase 8485494 cobQ2 1217310 cobQ2 Streptomyces avermitilis MA-4680 glutamine amidotransferase NP_828300.1 8484766 R 227882 CDS NP_828301.1 29833667 1217311 complement(8485517..8486755) 1 NC_003155.4 PF01225: Mur ligase family, catalytic domain; ligase 8486755 1217311 SAV_7125 Streptomyces avermitilis MA-4680 ligase NP_828301.1 8485517 R 227882 CDS NP_828302.1 29833668 1211671 8486898..8487458 1 NC_003155.4 polypeptide deformylase 8487458 def2 1211671 def2 Streptomyces avermitilis MA-4680 polypeptide deformylase NP_828302.1 8486898 D 227882 CDS NP_828303.1 29833669 1217312 complement(8487586..8488284) 1 NC_003155.4 TetR family transcriptional regulator 8488284 1217312 SAV_7127 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_828303.1 8487586 R 227882 CDS NP_828304.1 29833670 1211672 8488405..8489634 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 8489634 fadE6 1211672 fadE6 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_828304.1 8488405 D 227882 CDS NP_828305.1 29833671 1217313 complement(8489671..8490198) 1 NC_003155.4 PF00190: Cupin; hypothetical protein 8490198 1217313 SAV_7129 Streptomyces avermitilis MA-4680 hypothetical protein NP_828305.1 8489671 R 227882 CDS NP_828306.1 29833672 1211673 complement(8490207..8491421) 1 NC_003155.4 CYP158A3, adjacent to rpp; cytochrome P450 8491421 cyp25 1211673 cyp25 Streptomyces avermitilis MA-4680 cytochrome P450 NP_828306.1 8490207 R 227882 CDS NP_828307.1 29833673 1211674 complement(8491426..8492484) 1 NC_003155.4 PhlD homolog, PF02797: Chalcone and stilbene synthases, C-terminal domain; type III polyketide synthase 8492484 rppA 1211674 rppA Streptomyces avermitilis MA-4680 type III polyketide synthase NP_828307.1 8491426 R 227882 CDS NP_828308.1 29833674 1217314 8492643..8493359 1 NC_003155.4 hypothetical protein 8493359 1217314 SAV_7132 Streptomyces avermitilis MA-4680 hypothetical protein NP_828308.1 8492643 D 227882 CDS NP_828309.1 29833675 1217315 complement(8493375..8493614) 1 NC_003155.4 hypothetical protein 8493614 1217315 SAV_7133 Streptomyces avermitilis MA-4680 hypothetical protein NP_828309.1 8493375 R 227882 CDS NP_828310.1 29833676 1217316 complement(8493640..8495034) 1 NC_003155.4 NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; succinic semialdehyde dehydrogenase 8495034 gabD1 1217316 gabD1 Streptomyces avermitilis MA-4680 succinic semialdehyde dehydrogenase NP_828310.1 8493640 R 227882 CDS NP_828311.1 29833677 1217317 complement(8495108..8495572) 1 NC_003155.4 MutT-like protein 8495572 1217317 SAV_7135 Streptomyces avermitilis MA-4680 MutT-like protein NP_828311.1 8495108 R 227882 CDS NP_828312.1 29833678 1211675 complement(8495569..8497107) 1 NC_003155.4 catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; ATP-dependent DNA ligase 8497107 ligB 1211675 ligB Streptomyces avermitilis MA-4680 ATP-dependent DNA ligase NP_828312.1 8495569 R 227882 CDS NP_828313.1 29833679 1217318 complement(8497137..8498126) 1 NC_003155.4 reductase 8498126 1217318 SAV_7137 Streptomyces avermitilis MA-4680 reductase NP_828313.1 8497137 R 227882 CDS NP_828314.1 29833680 1217319 8498183..8498803 1 NC_003155.4 regulatory protein 8498803 1217319 SAV_7138 Streptomyces avermitilis MA-4680 regulatory protein NP_828314.1 8498183 D 227882 CDS NP_828315.1 29833681 1217320 8498823..8499866 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 8499866 1217320 SAV_7139 Streptomyces avermitilis MA-4680 dehydrogenase NP_828315.1 8498823 D 227882 CDS NP_828316.1 29833682 1211676 8499863..8501044 1 NC_003155.4 PF02770: Acyl-CoA dehydrogenase, middle domain; acyl-CoA dehydrogenase 8501044 fadE16 1211676 fadE16 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_828316.1 8499863 D 227882 CDS NP_828317.1 29833683 1211677 8501023..8502153 1 NC_003155.4 PF00441: Acyl-CoA dehydrogenase, C-terminal domain; acyl-CoA dehydrogenase 8502153 fadE21 1211677 fadE21 Streptomyces avermitilis MA-4680 acyl-CoA dehydrogenase NP_828317.1 8501023 D 227882 CDS NP_828318.1 29833684 1217321 8502328..8503188 1 NC_003155.4 protein 8503188 1217321 SAV_7142 Streptomyces avermitilis MA-4680 protein NP_828318.1 8502328 D 227882 CDS NP_828319.1 29833685 1217322 8503291..8503485 1 NC_003155.4 hypothetical protein 8503485 1217322 SAV_7143 Streptomyces avermitilis MA-4680 hypothetical protein NP_828319.1 8503291 D 227882 CDS NP_828320.1 29833686 1217323 complement(8503525..8504754) 1 NC_003155.4 protein 8504754 1217323 SAV_7144 Streptomyces avermitilis MA-4680 protein NP_828320.1 8503525 R 227882 CDS NP_828321.1 29833687 1217324 complement(8504830..8505198) 1 NC_003155.4 PF05610: Protein of unknown function (DUF779); hypothetical protein 8505198 1217324 SAV_7145 Streptomyces avermitilis MA-4680 hypothetical protein NP_828321.1 8504830 R 227882 CDS NP_828322.1 29833688 1217325 complement(8505258..8506025) 1 NC_003155.4 PF07702: UbiC transcription regulator-associated; GntR family transcriptional regulator 8506025 1217325 SAV_7146 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_828322.1 8505258 R 227882 CDS NP_828323.1 29833689 1211678 complement(8506099..8507988) 1 NC_003155.4 inositol metabolism, PF00205: Thiamine pyrophosphate enzyme, central domain; IolD protein 8507988 iolD2 1211678 iolD2 Streptomyces avermitilis MA-4680 IolD protein NP_828323.1 8506099 R 227882 CDS NP_828324.1 29833690 1217326 complement(8507996..8508901) 1 NC_003155.4 inositol metabolism, PF06845: Myo-inositol catabolism protein IolB; IolB protein 8508901 iolB2 1217326 iolB2 Streptomyces avermitilis MA-4680 IolB protein NP_828324.1 8507996 R 227882 CDS NP_828325.1 29833691 1217327 complement(8508931..8509809) 1 NC_003155.4 PF07157: DNA circulation protein N-terminus; hypothetical protein 8509809 1217327 SAV_7149 Streptomyces avermitilis MA-4680 hypothetical protein NP_828325.1 8508931 R 227882 CDS NP_828326.1 29833692 1217328 complement(8509835..8510791) 1 NC_003155.4 inositol metabolism, PF00294: pfkB family carbohydrate kinase; IolC protein 8510791 iolC2 1217328 iolC2 Streptomyces avermitilis MA-4680 IolC protein NP_828326.1 8509835 R 227882 CDS NP_828327.1 29833693 1217329 8511099..8512118 1 NC_003155.4 sugar ABC transporter substrate-binding protein 8512118 1217329 SAV_7151 Streptomyces avermitilis MA-4680 sugar ABC transporter substrate-binding protein NP_828327.1 8511099 D 227882 CDS NP_828328.1 29833694 1217330 8512124..8513197 1 NC_003155.4 sugar ABC transporter permease 8513197 1217330 SAV_7152 Streptomyces avermitilis MA-4680 sugar ABC transporter permease NP_828328.1 8512124 D 227882 CDS NP_828329.1 29833695 1217331 8513207..8514118 1 NC_003155.4 sugar ABC transporter ATP-binding protein 8514118 1217331 SAV_7153 Streptomyces avermitilis MA-4680 sugar ABC transporter ATP-binding protein NP_828329.1 8513207 D 227882 CDS NP_828330.1 29833696 1217332 8514120..8515022 1 NC_003155.4 inositol metaqbolism, PF06960: Myo-inositol catabolism protein N-terminus; IolE protein 8515022 iolE2 1217332 iolE2 Streptomyces avermitilis MA-4680 IolE protein NP_828330.1 8514120 D 227882 CDS NP_828331.1 29833697 1217333 complement(8515251..8516435) 1 NC_003155.4 PF01408: Oxidoreductase family, NAD-binding Rossmann fold; oxidoreductase 8516435 1217333 SAV_7155 Streptomyces avermitilis MA-4680 oxidoreductase NP_828331.1 8515251 R 227882 CDS NP_828332.1 29833698 1217334 8516580..8517596 1 NC_003155.4 PF00532: Periplasmic binding proteins and sugar binding domain of the LacI family; LacI family transcriptional regulator 8517596 1217334 SAV_7156 Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_828332.1 8516580 D 227882 CDS NP_828333.1 29833699 1217335 8517907..8518266 1 NC_003155.4 PF01740: STAS domain; hypothetical protein 8518266 1217335 SAV_7157 Streptomyces avermitilis MA-4680 hypothetical protein NP_828333.1 8517907 D 227882 CDS NP_828334.1 29833700 1217336 8518263..8519195 1 NC_003155.4 PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; regulator of sigma factor 8519195 prsR 1217336 prsR Streptomyces avermitilis MA-4680 regulator of sigma factor NP_828334.1 8518263 D 227882 CDS NP_828335.1 29833701 1211679 complement(8519323..8520771) 1 NC_003155.4 succinate-semialdehyde dehydrogenase, NADP-dependent 8520771 gabD3 1211679 gabD3 Streptomyces avermitilis MA-4680 succinate-semialdehyde dehydrogenase, NADP-dependent NP_828335.1 8519323 R 227882 CDS NP_828336.1 29833702 1217337 complement(8521230..8522489) 1 NC_003155.4 aminotransferase 8522489 1217337 SAV_7160 Streptomyces avermitilis MA-4680 aminotransferase NP_828336.1 8521230 R 227882 CDS NP_828337.1 29833703 1217338 8522760..8524415 1 NC_003155.4 nrps4 gene cluster; regulatory protein 8524415 1217338 SAV_7161 Streptomyces avermitilis MA-4680 regulatory protein NP_828337.1 8522760 D 227882 CDS NP_828338.1 29833704 1211680 complement(8524485..8525567) 1 NC_003155.4 nrps4 gene cluster; cysteine synthase 8525567 cysK3 1211680 cysK3 Streptomyces avermitilis MA-4680 cysteine synthase NP_828338.1 8524485 R 227882 CDS NP_828339.1 29833705 1211681 complement(8525756..8526826) 1 NC_003155.4 nrps4 gene cluster; ornithine cyclodeaminase 8526826 arcB4 1211681 arcB4 Streptomyces avermitilis MA-4680 ornithine cyclodeaminase NP_828339.1 8525756 R 227882 CDS NP_828340.1 29833706 1217339 complement(8526823..8527794) 1 NC_003155.4 nrps4 gene cluster; SyrP-like protein 8527794 1217339 SAV_7164 Streptomyces avermitilis MA-4680 SyrP-like protein NP_828340.1 8526823 R 227882 CDS NP_828341.1 29833707 1217340 complement(8527980..8530697) 1 NC_003155.4 nrps4 gene cluster; non-ribosomal peptide synthetase 8530697 nrps4 1217340 nrps4 Streptomyces avermitilis MA-4680 non-ribosomal peptide synthetase NP_828341.1 8527980 R 227882 CDS NP_828342.1 29833708 1217341 8531505..8533463 1 NC_003155.4 amidase 8533463 1217341 SAV_7166 Streptomyces avermitilis MA-4680 amidase NP_828342.1 8531505 D 227882 CDS NP_828343.1 29833709 1217342 complement(8534240..8534830) 1 NC_003155.4 TetR family transcriptional regulator 8534830 1217342 SAV_7167 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_828343.1 8534240 R 227882 CDS NP_828344.1 29833710 1217343 8534873..8535412 1 NC_003155.4 PF01361: Tautomerase enzyme; hypothetical protein 8535412 1217343 SAV_7168 Streptomyces avermitilis MA-4680 hypothetical protein NP_828344.1 8534873 D 227882 CDS NP_828345.1 29833711 1217344 8535405..8536415 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 8536415 1217344 SAV_7169 Streptomyces avermitilis MA-4680 dehydrogenase NP_828345.1 8535405 D 227882 CDS NP_828346.1 29833712 1217345 8536960..8537487 1 NC_003155.4 hypothetical protein 8537487 1217345 SAV_7170 Streptomyces avermitilis MA-4680 hypothetical protein NP_828346.1 8536960 D 227882 CDS NP_828347.1 29833713 1217346 complement(8537697..8538272) 1 NC_003155.4 hypothetical protein 8538272 1217346 SAV_7171 Streptomyces avermitilis MA-4680 hypothetical protein NP_828347.1 8537697 R 227882 CDS NP_828348.1 29833714 1217347 complement(8538378..8540762) 1 NC_003155.4 PF01590: GAF domain; magnesium or manganese-dependent protein phosphatase 8540762 prpJ7 1217347 prpJ7 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_828348.1 8538378 R 227882 CDS NP_828349.1 29833715 1217348 8541622..8541942 1 NC_003155.4 hypothetical protein 8541942 1217348 SAV_7173 Streptomyces avermitilis MA-4680 hypothetical protein NP_828349.1 8541622 D 227882 CDS NP_828350.1 29833716 1217349 8542083..8542616 1 NC_003155.4 hypothetical protein 8542616 1217349 SAV_7174 Streptomyces avermitilis MA-4680 hypothetical protein NP_828350.1 8542083 D 227882 CDS NP_828351.1 29833717 1217350 complement(8542664..8542870) 1 NC_003155.4 hypothetical protein 8542870 1217350 SAV_7175 Streptomyces avermitilis MA-4680 hypothetical protein NP_828351.1 8542664 R 227882 CDS NP_828352.1 29833718 1217351 complement(8543264..8543524) 1 NC_003155.4 hypothetical protein 8543524 1217351 SAV_7176 Streptomyces avermitilis MA-4680 hypothetical protein NP_828352.1 8543264 R 227882 CDS NP_828353.1 29833719 1211682 complement(8543834..8545357) 1 NC_003155.4 PF00171: Aldehyde dehydrogenase family; aldehyde dehydrogenase 8545357 thcA 1211682 thcA Streptomyces avermitilis MA-4680 aldehyde dehydrogenase NP_828353.1 8543834 R 227882 CDS NP_828354.1 29833720 1217352 complement(8545481..8546770) 1 NC_003155.4 transcriptional regulator 8546770 1217352 SAV_7178 Streptomyces avermitilis MA-4680 transcriptional regulator NP_828354.1 8545481 R 227882 CDS NP_828355.1 29833721 1217353 complement(8546880..8547479) 1 NC_003155.4 PF01510: N-acetylmuramoyl-L-alanine amidase; N-acetylmuramoyl-L-alanine amidase 8547479 amiA2 1217353 amiA2 Streptomyces avermitilis MA-4680 N-acetylmuramoyl-L-alanine amidase NP_828355.1 8546880 R 227882 CDS NP_828356.1 29833722 1211683 complement(8548061..8549299) 1 NC_003155.4 xylose repressor 8549299 xylR 1211683 xylR Streptomyces avermitilis MA-4680 xylose repressor NP_828356.1 8548061 R 227882 CDS NP_828357.2 57833867 1211684 complement(8549337..8550782) 1 NC_003155.4 PF00370: FGGY family of carbohydrate kinases, N-terminal domain; xylulose kinase 8550782 xylB1 1211684 xylB1 Streptomyces avermitilis MA-4680 xylulose kinase NP_828357.2 8549337 R 227882 CDS NP_828358.1 29833724 1211685 8550993..8552159 1 NC_003155.4 catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase 8552159 xylA 1211685 xylA Streptomyces avermitilis MA-4680 xylose isomerase NP_828358.1 8550993 D 227882 CDS NP_828359.1 29833725 1217354 8552704..8553312 1 NC_003155.4 PF04886: PT repeat; hypothetical protein 8553312 1217354 SAV_7183 Streptomyces avermitilis MA-4680 hypothetical protein NP_828359.1 8552704 D 227882 CDS NP_828360.1 29833726 1217355 complement(8553602..8558155) 1 NC_003155.4 pks4 gene cluster; modular polyketide synthase 8558155 pks4 1217355 pks4 Streptomyces avermitilis MA-4680 modular polyketide synthase NP_828360.1 8553602 R 227882 CDS NP_828361.1 29833727 1217356 complement(8559018..8560301) 1 NC_003155.4 pks4 gene cluster, PF03033: Glycosyltransferase family 28 N-terminal domain; UDP-glucose:sterol glucosyltransferase 8560301 1217356 SAV_7185 Streptomyces avermitilis MA-4680 UDP-glucose:sterol glucosyltransferase NP_828361.1 8559018 R 227882 CDS NP_828362.1 29833728 1211686 complement(8560411..8561604) 1 NC_003155.4 CYP105R1, pks4 gene cluster; cytochrome P450 hydroxylase 8561604 cyp26 1211686 cyp26 Streptomyces avermitilis MA-4680 cytochrome P450 hydroxylase NP_828362.1 8560411 R 227882 CDS NP_828363.1 29833729 1217357 8561754..8563319 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 8563319 1217357 SAV_7187 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_828363.1 8561754 D 227882 CDS NP_828364.1 29833730 1217358 complement(8563465..8564472) 1 NC_003155.4 PF01408: Oxidoreductase family, NAD-binding Rossmann fold; oxidoreductase 8564472 1217358 SAV_7188 Streptomyces avermitilis MA-4680 oxidoreductase NP_828364.1 8563465 R 227882 CDS NP_828365.1 29833731 1217359 complement(8564504..8565325) 1 NC_003155.4 PF00106: short chain dehydrogenase; short chain dehydrogenase 8565325 1217359 SAV_7189 Streptomyces avermitilis MA-4680 short chain dehydrogenase NP_828365.1 8564504 R 227882 CDS NP_828366.1 29833732 1217360 complement(8565339..8566514) 1 NC_003155.4 PF05721: Phytanoyl-CoA dioxygenase (PhyH); hypothetical protein 8566514 1217360 SAV_7190 Streptomyces avermitilis MA-4680 hypothetical protein NP_828366.1 8565339 R 227882 CDS NP_828367.1 29833733 1217361 8566612..8567661 1 NC_003155.4 DNA-binding protein 8567661 1217361 SAV_7191 Streptomyces avermitilis MA-4680 DNA-binding protein NP_828367.1 8566612 D 227882 CDS NP_828368.1 29833734 1217362 8567815..8568180 1 NC_003155.4 hypothetical protein 8568180 1217362 SAV_7192 Streptomyces avermitilis MA-4680 hypothetical protein NP_828368.1 8567815 D 227882 CDS NP_828369.1 29833735 1217363 complement(8568544..8569554) 1 NC_003155.4 PF02541: Ppx/GppA phosphatase family; exopolyphosphatase 8569554 ppx3 1217363 ppx3 Streptomyces avermitilis MA-4680 exopolyphosphatase NP_828369.1 8568544 R 227882 CDS NP_828370.1 29833736 1217364 8569752..8570417 1 NC_003155.4 methyltransferase 8570417 1217364 SAV_7194 Streptomyces avermitilis MA-4680 methyltransferase NP_828370.1 8569752 D 227882 CDS NP_828371.1 29833737 1217365 8570401..8570610 1 NC_003155.4 hypothetical protein 8570610 1217365 SAV_7195 Streptomyces avermitilis MA-4680 hypothetical protein NP_828371.1 8570401 D 227882 CDS NP_828372.1 29833738 1217366 8570607..8571629 1 NC_003155.4 hypothetical protein 8571629 1217366 SAV_7196 Streptomyces avermitilis MA-4680 hypothetical protein NP_828372.1 8570607 D 227882 CDS NP_828373.1 29833739 1211687 8571613..8572494 1 NC_003155.4 ribitol dehydrogenase 8572494 rdh 1211687 rdh Streptomyces avermitilis MA-4680 ribitol dehydrogenase NP_828373.1 8571613 D 227882 CDS NP_828374.1 29833740 1217367 complement(8572537..8573436) 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 8573436 1217367 SAV_7198 Streptomyces avermitilis MA-4680 hydrolase NP_828374.1 8572537 R 227882 CDS NP_828375.1 29833741 1217368 8573497..8573883 1 NC_003155.4 PF01638: Transcriptional regulator; transcriptional regulator 8573883 1217368 SAV_7199 Streptomyces avermitilis MA-4680 transcriptional regulator NP_828375.1 8573497 D 227882 CDS NP_828376.1 29833742 1217369 8574316..8575161 1 NC_003155.4 PF00230: Major intrinsic protein; transport integral membrane protein 8575161 1217369 SAV_7200 Streptomyces avermitilis MA-4680 transport integral membrane protein NP_828376.1 8574316 D 227882 CDS NP_828377.1 29833743 1211688 8575186..8576703 1 NC_003155.4 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 8576703 glpK 1211688 glpK Streptomyces avermitilis MA-4680 glycerol kinase NP_828377.1 8575186 D 227882 CDS NP_828378.1 29833744 1217370 complement(8577139..8577666) 1 NC_003155.4 hypothetical protein 8577666 1217370 SAV_7202 Streptomyces avermitilis MA-4680 hypothetical protein NP_828378.1 8577139 R 227882 CDS NP_828379.1 29833745 1217371 8577945..8579495 1 NC_003155.4 PF00266: Aminotransferase class-V; hypothetical protein 8579495 1217371 SAV_7203 Streptomyces avermitilis MA-4680 hypothetical protein NP_828379.1 8577945 D 227882 CDS NP_828380.1 29833746 1217372 8579581..8581101 1 NC_003155.4 hypothetical protein 8581101 1217372 SAV_7204 Streptomyces avermitilis MA-4680 hypothetical protein NP_828380.1 8579581 D 227882 CDS NP_828381.1 29833747 1211690 complement(8581221..8582018) 1 NC_003155.4 phosphomethylpyrimidine kinase 8582018 thiD 1211690 thiD Streptomyces avermitilis MA-4680 phosphomethylpyrimidine kinase NP_828381.1 8581221 R 227882 CDS NP_828382.1 29833748 1217373 complement(8582015..8583430) 1 NC_003155.4 cytosine permease 8583430 1217373 SAV_7206 Streptomyces avermitilis MA-4680 cytosine permease NP_828382.1 8582015 R 227882 CDS NP_828383.1 29833749 1217374 complement(8583610..8584947) 1 NC_003155.4 PF03372: Endonuclease/Exonuclease/phosphatase family; hypothetical protein 8584947 1217374 SAV_7207 Streptomyces avermitilis MA-4680 hypothetical protein NP_828383.1 8583610 R 227882 CDS NP_828384.1 29833750 1217375 8585756..8586712 1 NC_003155.4 ABC transporter permease 8586712 1217375 SAV_7208 Streptomyces avermitilis MA-4680 ABC transporter permease NP_828384.1 8585756 D 227882 CDS NP_828385.1 29833751 1217376 8586709..8587494 1 NC_003155.4 ABC transporter ATP-binding protein 8587494 1217376 SAV_7209 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_828385.1 8586709 D 227882 CDS NP_828386.1 29833752 1217377 8587567..8588592 1 NC_003155.4 ABC transporter substrate-binding protein 8588592 1217377 SAV_7210 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_828386.1 8587567 D 227882 CDS NP_828387.1 29833753 1217378 8588620..8589378 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 8589378 1217378 SAV_7211 Streptomyces avermitilis MA-4680 acetyltransferase NP_828387.1 8588620 D 227882 CDS NP_828388.1 29833754 1217379 8589594..8590856 1 NC_003155.4 FMNH2-utilizing oxygenase 8590856 1217379 SAV_7212 Streptomyces avermitilis MA-4680 FMNH2-utilizing oxygenase NP_828388.1 8589594 D 227882 CDS NP_828389.1 29833755 1217380 8590876..8592252 1 NC_003155.4 FMNH2-utilizing oxygenase 8592252 1217380 SAV_7213 Streptomyces avermitilis MA-4680 FMNH2-utilizing oxygenase NP_828389.1 8590876 D 227882 CDS NP_828390.1 29833756 1211691 complement(8592489..8594708) 1 NC_003155.4 isocitrate dehydrogenase 8594708 icdA 1211691 icdA Streptomyces avermitilis MA-4680 isocitrate dehydrogenase NP_828390.1 8592489 R 227882 CDS NP_828391.1 29833757 1217381 complement(8595290..8596465) 1 NC_003155.4 PF00924: Mechanosensitive ion channel; integral membrane protein 8596465 1217381 SAV_7215 Streptomyces avermitilis MA-4680 integral membrane protein NP_828391.1 8595290 R 227882 CDS NP_828392.1 29833758 1211692 complement(8596791..8597558) 1 NC_003155.4 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 8597558 echA15 1211692 echA15 Streptomyces avermitilis MA-4680 enoyl-CoA hydratase NP_828392.1 8596791 R 227882 CDS NP_828393.1 29833759 1217382 complement(8597655..8598521) 1 NC_003155.4 PF03706: Uncharacterised protein family (UPF0104); hypothetical protein 8598521 1217382 SAV_7217 Streptomyces avermitilis MA-4680 hypothetical protein NP_828393.1 8597655 R 227882 CDS NP_828394.1 29833760 1217383 8598813..8600720 1 NC_003155.4 ABC transporter ATP-binding protein 8600720 1217383 SAV_7218 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_828394.1 8598813 D 227882 CDS NP_828395.1 29833761 1211693 8601038..8603263 1 NC_003155.4 PF00912: Transglycosylase; penicillin-binding protein 8603263 pbp12 1211693 pbp12 Streptomyces avermitilis MA-4680 penicillin-binding protein NP_828395.1 8601038 D 227882 CDS NP_828396.1 29833762 1217384 8603412..8604638 1 NC_003155.4 hypothetical protein 8604638 1217384 SAV_7220 Streptomyces avermitilis MA-4680 hypothetical protein NP_828396.1 8603412 D 227882 CDS NP_828397.1 29833763 1217385 8604802..8605935 1 NC_003155.4 hypothetical protein 8605935 1217385 SAV_7221 Streptomyces avermitilis MA-4680 hypothetical protein NP_828397.1 8604802 D 227882 CDS NP_828398.1 29833764 1217386 8606063..8607682 1 NC_003155.4 hypothetical protein 8607682 1217386 SAV_7222 Streptomyces avermitilis MA-4680 hypothetical protein NP_828398.1 8606063 D 227882 CDS NP_828399.1 29833765 1217387 8607682..8609019 1 NC_003155.4 hypothetical protein 8609019 1217387 SAV_7223 Streptomyces avermitilis MA-4680 hypothetical protein NP_828399.1 8607682 D 227882 CDS NP_828400.1 29833766 1217388 8609016..8613215 1 NC_003155.4 PF01576: Myosin tail; hypothetical protein 8613215 1217388 SAV_7224 Streptomyces avermitilis MA-4680 hypothetical protein NP_828400.1 8609016 D 227882 CDS NP_828401.1 29833767 1217389 8613212..8614549 1 NC_003155.4 hypothetical protein 8614549 1217389 SAV_7225 Streptomyces avermitilis MA-4680 hypothetical protein NP_828401.1 8613212 D 227882 CDS NP_828402.1 29833768 1217390 complement(8614617..8615825) 1 NC_003155.4 PF00106: short chain dehydrogenase; short chain dehydrogenase 8615825 1217390 SAV_7226 Streptomyces avermitilis MA-4680 short chain dehydrogenase NP_828402.1 8614617 R 227882 CDS NP_828403.1 29833769 1217391 8616415..8616951 1 NC_003155.4 hypothetical protein 8616951 1217391 SAV_7227 Streptomyces avermitilis MA-4680 hypothetical protein NP_828403.1 8616415 D 227882 CDS NP_828404.1 29833770 1217392 complement(8616956..8619310) 1 NC_003155.4 PF05976: Bacterial membrane protein of unknown function (DUF893); hypothetical protein 8619310 1217392 SAV_7228 Streptomyces avermitilis MA-4680 hypothetical protein NP_828404.1 8616956 R 227882 CDS NP_828405.1 29833771 1217393 complement(8619439..8620614) 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; glutathione-independent formaldehyde dehydrogenase 8620614 1217393 SAV_7229 Streptomyces avermitilis MA-4680 glutathione-independent formaldehyde dehydrogenase NP_828405.1 8619439 R 227882 CDS NP_828406.1 29833772 1217394 complement(8620952..8622373) 1 NC_003155.4 hypothetical protein 8622373 1217394 SAV_7230 Streptomyces avermitilis MA-4680 hypothetical protein NP_828406.1 8620952 R 227882 CDS NP_828407.1 29833773 1217395 complement(8622783..8623439) 1 NC_003155.4 PF01965: DJ-1/PfpI family; intracellular protease/amidase 8623439 pfpI2 1217395 pfpI2 Streptomyces avermitilis MA-4680 intracellular protease/amidase NP_828407.1 8622783 R 227882 CDS NP_828408.1 29833774 1217396 complement(8623814..8624419) 1 NC_003155.4 hypothetical protein 8624419 1217396 SAV_7232 Streptomyces avermitilis MA-4680 hypothetical protein NP_828408.1 8623814 R 227882 CDS NP_828409.1 29833775 1217397 complement(8624703..8625548) 1 NC_003155.4 PF00248: Aldo/keto reductase family; oxidoreductase 8625548 1217397 SAV_7233 Streptomyces avermitilis MA-4680 oxidoreductase NP_828409.1 8624703 R 227882 CDS NP_828410.1 29833776 1217398 complement(8625651..8626844) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; multidrug efflux protein 8626844 1217398 SAV_7234 Streptomyces avermitilis MA-4680 multidrug efflux protein NP_828410.1 8625651 R 227882 CDS NP_828411.1 29833777 1217399 8627105..8627995 1 NC_003155.4 LysR family transcriptional regulator 8627995 1217399 SAV_7235 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_828411.1 8627105 D 227882 CDS NP_828412.1 29833778 1217400 complement(8628137..8629918) 1 NC_003155.4 PF05651: Putative sugar diacid recognition; hypothetical protein 8629918 1217400 SAV_7236 Streptomyces avermitilis MA-4680 hypothetical protein NP_828412.1 8628137 R 227882 CDS NP_828413.1 29833779 1211694 8630200..8632101 1 NC_003155.4 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 8632101 dnaK 1211694 dnaK Streptomyces avermitilis MA-4680 molecular chaperone DnaK NP_828413.1 8630200 D 227882 CDS NP_828414.1 29833780 1211695 8632110..8632721 1 NC_003155.4 GrpE homologue 8632721 grpE2 1211695 grpE2 Streptomyces avermitilis MA-4680 GrpE homologue NP_828414.1 8632110 D 227882 CDS NP_828415.1 29833781 1211696 8632728..8633681 1 NC_003155.4 heat shock protein DnaJ 8633681 dnaJ2 1211696 dnaJ2 Streptomyces avermitilis MA-4680 heat shock protein DnaJ NP_828415.1 8632728 D 227882 CDS NP_828416.1 29833782 1217401 8633678..8634085 1 NC_003155.4 PF00376: MerR family regulatory protein; hypothetical protein 8634085 1217401 SAV_7240 Streptomyces avermitilis MA-4680 hypothetical protein NP_828416.1 8633678 D 227882 CDS NP_828417.1 29833783 1211697 8634076..8636715 1 NC_003155.4 PF07724: ATPase family associated with various cellular activities (AAA); ATP-dependent Clp protease 8636715 clpB2 1211697 clpB2 Streptomyces avermitilis MA-4680 ATP-dependent Clp protease NP_828417.1 8634076 D 227882 CDS NP_828418.1 29833784 1211698 8636703..8637158 1 NC_003155.4 thioredoxin 8637158 trxA2 1211698 trxA2 Streptomyces avermitilis MA-4680 thioredoxin NP_828418.1 8636703 D 227882 CDS NP_828419.1 29833785 1211699 8637391..8639241 1 NC_003155.4 thioredoxin reductase 8639241 trxB2 1211699 trxB2 Streptomyces avermitilis MA-4680 thioredoxin reductase NP_828419.1 8637391 D 227882 CDS NP_828420.1 29833786 1217402 8639255..8639617 1 NC_003155.4 PF00011: Hsp20/alpha crystallin family; hypothetical protein 8639617 1217402 SAV_7244 Streptomyces avermitilis MA-4680 hypothetical protein NP_828420.1 8639255 D 227882 CDS NP_828421.1 29833787 1211700 8640232..8640651 1 NC_003155.4 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 8640651 panD 1211700 panD Streptomyces avermitilis MA-4680 aspartate alpha-decarboxylase NP_828421.1 8640232 D 227882 CDS NP_828422.1 29833788 1217403 8640688..8641032 1 NC_003155.4 hypothetical protein 8641032 1217403 SAV_7246 Streptomyces avermitilis MA-4680 hypothetical protein NP_828422.1 8640688 D 227882 CDS NP_828423.1 29833789 1217404 8641002..8641742 1 NC_003155.4 hypothetical protein 8641742 1217404 SAV_7247 Streptomyces avermitilis MA-4680 hypothetical protein NP_828423.1 8641002 D 227882 CDS NP_828424.1 29833790 1217405 8641813..8642034 1 NC_003155.4 hypothetical protein 8642034 1217405 SAV_7248 Streptomyces avermitilis MA-4680 hypothetical protein NP_828424.1 8641813 D 227882 CDS NP_828425.1 29833791 1211701 complement(8642147..8643586) 1 NC_003155.4 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 8643586 gnd3 1211701 gnd3 Streptomyces avermitilis MA-4680 6-phosphogluconate dehydrogenase NP_828425.1 8642147 R 227882 CDS NP_828426.1 29833792 1217406 8643887..8645080 1 NC_003155.4 PF01551: Peptidase family M23; peptidase 8645080 1217406 SAV_7250 Streptomyces avermitilis MA-4680 peptidase NP_828426.1 8643887 D 227882 CDS NP_828427.1 29833793 1217407 complement(8645070..8646197) 1 NC_003155.4 PF05653: Protein of unknown function (DUF803); hypothetical protein 8646197 1217407 SAV_7251 Streptomyces avermitilis MA-4680 hypothetical protein NP_828427.1 8645070 R 227882 CDS NP_828428.1 29833794 1217408 8646408..8647133 1 NC_003155.4 PF06276: Ferric iron reductase protein FhuF; hypothetical protein 8647133 1217408 SAV_7252 Streptomyces avermitilis MA-4680 hypothetical protein NP_828428.1 8646408 D 227882 CDS NP_828429.1 29833795 1211702 8647207..8648358 1 NC_003155.4 PF00534: Glycosyl transferases group 1; glycosyl transferase 8648358 glgA2 1211702 glgA2 Streptomyces avermitilis MA-4680 glycosyl transferase NP_828429.1 8647207 D 227882 CDS NP_828430.1 29833796 1211703 8648395..8649615 1 NC_003155.4 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 8649615 glgC 1211703 glgC Streptomyces avermitilis MA-4680 glucose-1-phosphate adenylyltransferase NP_828430.1 8648395 D 227882 CDS NP_828431.1 29833797 1217409 8649736..8652069 1 NC_003155.4 protein 8652069 1217409 SAV_7255 Streptomyces avermitilis MA-4680 protein NP_828431.1 8649736 D 227882 CDS NP_828432.1 29833798 1217410 8652210..8653553 1 NC_003155.4 PF03007: Uncharacterised protein family (UPF0089); hypothetical protein 8653553 1217410 SAV_7256 Streptomyces avermitilis MA-4680 hypothetical protein NP_828432.1 8652210 D 227882 CDS NP_828433.1 29833799 1217411 8653701..8655185 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 8655185 1217411 SAV_7257 Streptomyces avermitilis MA-4680 dehydrogenase NP_828433.1 8653701 D 227882 CDS NP_828434.1 29833800 1217412 8655203..8655514 1 NC_003155.4 hypothetical protein 8655514 1217412 SAV_7258 Streptomyces avermitilis MA-4680 hypothetical protein NP_828434.1 8655203 D 227882 CDS NP_828435.1 29833801 1211704 complement(8655567..8656373) 1 NC_003155.4 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 8656373 fabG 1211704 fabG Streptomyces avermitilis MA-4680 3-ketoacyl-ACP reductase NP_828435.1 8655567 R 227882 CDS NP_828436.1 29833802 1217413 complement(8656399..8656947) 1 NC_003155.4 hypothetical protein 8656947 1217413 SAV_7260 Streptomyces avermitilis MA-4680 hypothetical protein NP_828436.1 8656399 R 227882 CDS NP_828437.1 29833803 1217414 8657747..8658229 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; acetyltransferase 8658229 1217414 SAV_7261 Streptomyces avermitilis MA-4680 acetyltransferase NP_828437.1 8657747 D 227882 CDS NP_828438.1 29833804 1217415 complement(8658263..8660257) 1 NC_003155.4 hypothetical protein 8660257 1217415 SAV_7262 Streptomyces avermitilis MA-4680 hypothetical protein NP_828438.1 8658263 R 227882 CDS NP_828439.1 29833805 1217416 8660501..8661892 1 NC_003155.4 ABC transporter substrate-binding protein 8661892 1217416 SAV_7263 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_828439.1 8660501 D 227882 CDS NP_828440.1 29833806 1211705 8661889..8662830 1 NC_003155.4 L-arabinose ABC transporter permease 8662830 araP 1211705 araP Streptomyces avermitilis MA-4680 L-arabinose ABC transporter permease NP_828440.1 8661889 D 227882 CDS NP_828441.1 29833807 1211706 8662827..8663702 1 NC_003155.4 L-arabinose ABC transporter permease 8663702 araQ 1211706 araQ Streptomyces avermitilis MA-4680 L-arabinose ABC transporter permease NP_828441.1 8662827 D 227882 CDS NP_828442.1 29833808 1217417 8663699..8665531 1 NC_003155.4 PF02065: Melibiase; hypothetical protein 8665531 1217417 SAV_7266 Streptomyces avermitilis MA-4680 hypothetical protein NP_828442.1 8663699 D 227882 CDS NP_828443.1 29833809 1211707 8665528..8666526 1 NC_003155.4 LacI-family transcriptional regulator; MalR repressor protein 8666526 malR2 1211707 malR2 Streptomyces avermitilis MA-4680 MalR repressor protein NP_828443.1 8665528 D 227882 CDS NP_828444.1 29833810 1217418 8666657..8668534 1 NC_003155.4 hypothetical protein 8668534 1217418 SAV_7268 Streptomyces avermitilis MA-4680 hypothetical protein NP_828444.1 8666657 D 227882 CDS NP_828445.1 29833811 1217419 complement(8668562..8669926) 1 NC_003155.4 amidase 8669926 amiE1 1217419 amiE1 Streptomyces avermitilis MA-4680 amidase NP_828445.1 8668562 R 227882 CDS NP_828446.1 29833812 1217420 complement(8670159..8671202) 1 NC_003155.4 LacI family transcriptional regulator 8671202 1217420 SAV_7270 Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_828446.1 8670159 R 227882 CDS NP_828447.1 29833813 1217421 8671422..8672714 1 NC_003155.4 ABC transporter substrate-binding protein 8672714 1217421 SAV_7271 Streptomyces avermitilis MA-4680 ABC transporter substrate-binding protein NP_828447.1 8671422 D 227882 CDS NP_828448.1 29833814 1217422 8672721..8673614 1 NC_003155.4 ABC transporter permease 8673614 1217422 SAV_7272 Streptomyces avermitilis MA-4680 ABC transporter permease NP_828448.1 8672721 D 227882 CDS NP_828449.1 29833815 1217423 8673611..8674516 1 NC_003155.4 ABC transporter permease 8674516 1217423 SAV_7273 Streptomyces avermitilis MA-4680 ABC transporter permease NP_828449.1 8673611 D 227882 CDS NP_828450.1 29833816 1217424 8674569..8675801 1 NC_003155.4 hypothetical protein 8675801 1217424 SAV_7274 Streptomyces avermitilis MA-4680 hypothetical protein NP_828450.1 8674569 D 227882 CDS NP_828451.1 29833817 1217425 8675831..8676259 1 NC_003155.4 hypothetical protein 8676259 1217425 SAV_7275 Streptomyces avermitilis MA-4680 hypothetical protein NP_828451.1 8675831 D 227882 CDS NP_828452.1 29833818 1211708 8676290..8677834 1 NC_003155.4 endo-beta-N-acetylglucosaminidase 8677834 endoH 1211708 endoH Streptomyces avermitilis MA-4680 endo-beta-N-acetylglucosaminidase NP_828452.1 8676290 D 227882 CDS NP_828453.1 29833819 1211709 8677864..8680878 1 NC_003155.4 alpha-mannosidase 8680878 ama2 1211709 ama2 Streptomyces avermitilis MA-4680 alpha-mannosidase NP_828453.1 8677864 D 227882 CDS NP_828454.1 29833820 1217426 complement(8680918..8681619) 1 NC_003155.4 GntR family transcriptional regulator 8681619 1217426 SAV_7278 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_828454.1 8680918 R 227882 CDS NP_828455.1 29833821 1217427 8681784..8682830 1 NC_003155.4 sugar ABC transporter substrate-binding protein 8682830 1217427 SAV_7279 Streptomyces avermitilis MA-4680 sugar ABC transporter substrate-binding protein NP_828455.1 8681784 D 227882 CDS NP_828456.1 29833822 1217428 8682827..8684392 1 NC_003155.4 sugar ABC transporter ATP-binding protein 8684392 1217428 SAV_7280 Streptomyces avermitilis MA-4680 sugar ABC transporter ATP-binding protein NP_828456.1 8682827 D 227882 CDS NP_828457.1 29833823 1217429 8684451..8685410 1 NC_003155.4 PF02653: Branched-chain amino acid transport system / permease component; sugar ABC transporter integral membrane subunit 8685410 1217429 SAV_7281 Streptomyces avermitilis MA-4680 sugar ABC transporter integral membrane subunit NP_828457.1 8684451 D 227882 CDS NP_828458.1 29833824 1211710 8685461..8686801 1 NC_003155.4 mandelate racemase 8686801 menC 1211710 menC Streptomyces avermitilis MA-4680 mandelate racemase NP_828458.1 8685461 D 227882 CDS NP_828459.1 29833825 1217430 8686798..8687553 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 8687553 1217430 SAV_7283 Streptomyces avermitilis MA-4680 dehydrogenase NP_828459.1 8686798 D 227882 CDS NP_828460.1 29833826 1217431 8687550..8688536 1 NC_003155.4 PF00248: Aldo/keto reductase family; oxidoreductase 8688536 1217431 SAV_7284 Streptomyces avermitilis MA-4680 oxidoreductase NP_828460.1 8687550 D 227882 CDS NP_828461.1 29833827 1217432 8688533..8688847 1 NC_003155.4 PF05336: Protein of unknown function (DUF718); hypothetical protein 8688847 1217432 SAV_7285 Streptomyces avermitilis MA-4680 hypothetical protein NP_828461.1 8688533 D 227882 CDS NP_828462.1 29833828 1217433 8688832..8689683 1 NC_003155.4 PF04909: Amidohydrolase; hypothetical protein 8689683 1217433 SAV_7286 Streptomyces avermitilis MA-4680 hypothetical protein NP_828462.1 8688832 D 227882 CDS NP_828463.1 29833829 1217434 complement(8689766..8691193) 1 NC_003155.4 PF06762: Protein of unknown function (DUF1222); integral membrane protein 8691193 1217434 SAV_7287 Streptomyces avermitilis MA-4680 integral membrane protein NP_828463.1 8689766 R 227882 CDS NP_828464.1 29833830 1217435 8691505..8693577 1 NC_003155.4 PF00785: PAC motif; magnesium or manganese-dependent protein phosphatase 8693577 prpM4 1217435 prpM4 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_828464.1 8691505 D 227882 CDS NP_828465.1 29833831 1211711 8693625..8694485 1 NC_003155.4 formamidopyrimidine-DNA glycosylase 8694485 mutM2 1211711 mutM2 Streptomyces avermitilis MA-4680 formamidopyrimidine-DNA glycosylase NP_828465.1 8693625 D 227882 CDS NP_828466.1 29833832 1217436 complement(8694529..8695179) 1 NC_003155.4 hypothetical protein 8695179 1217436 SAV_7290 Streptomyces avermitilis MA-4680 hypothetical protein NP_828466.1 8694529 R 227882 CDS NP_828467.1 29833833 1217437 complement(8695328..8695843) 1 NC_003155.4 hypothetical protein 8695843 1217437 SAV_7291 Streptomyces avermitilis MA-4680 hypothetical protein NP_828467.1 8695328 R 227882 CDS NP_828468.1 29833834 1211712 complement(8695996..8696544) 1 NC_003155.4 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. tuberculosis this protein regulates polyketide synthases and or membrane proteins; RNA polymerase sigma factor SigL 8696544 sig56 1211712 sig56 Streptomyces avermitilis MA-4680 RNA polymerase sigma factor SigL NP_828468.1 8695996 R 227882 CDS NP_828469.1 29833835 1217438 8696830..8697978 1 NC_003155.4 lipoprotein 8697978 1217438 SAV_7293 Streptomyces avermitilis MA-4680 lipoprotein NP_828469.1 8696830 D 227882 CDS NP_828470.1 29833836 1217439 complement(8697965..8699383) 1 NC_003155.4 PF00324: Amino acid permease; amino acid transporter protein 8699383 1217439 SAV_7294 Streptomyces avermitilis MA-4680 amino acid transporter protein NP_828470.1 8697965 R 227882 CDS NP_828471.1 29833837 1217440 complement(8699546..8700007) 1 NC_003155.4 PF00582: Universal stress protein family; hypothetical protein 8700007 1217440 SAV_7295 Streptomyces avermitilis MA-4680 hypothetical protein NP_828471.1 8699546 R 227882 CDS NP_828472.1 29833838 1211713 8700179..8703460 1 NC_003155.4 catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 8703460 lysS 1211713 lysS Streptomyces avermitilis MA-4680 lysyl-tRNA synthetase NP_828472.1 8700179 D 227882 CDS NP_828473.1 29833839 1217441 8703619..8704467 1 NC_003155.4 oligosaccharide deacetylase 8704467 1217441 SAV_7297 Streptomyces avermitilis MA-4680 oligosaccharide deacetylase NP_828473.1 8703619 D 227882 CDS NP_828474.1 29833840 1217442 complement(8704497..8705207) 1 NC_003155.4 PF04203: Sortase family; hypothetical protein 8705207 1217442 SAV_7298 Streptomyces avermitilis MA-4680 hypothetical protein NP_828474.1 8704497 R 227882 CDS NP_828475.1 29833841 1217443 8705496..8706716 1 NC_003155.4 hypothetical protein 8706716 1217443 SAV_7299 Streptomyces avermitilis MA-4680 hypothetical protein NP_828475.1 8705496 D 227882 CDS NP_828476.1 29833842 1217444 complement(8706878..8707642) 1 NC_003155.4 hypothetical protein 8707642 1217444 SAV_7300 Streptomyces avermitilis MA-4680 hypothetical protein NP_828476.1 8706878 R 227882 CDS NP_828477.1 29833843 1217445 complement(8707659..8708279) 1 NC_003155.4 proline-rich protein 8708279 1217445 SAV_7301 Streptomyces avermitilis MA-4680 proline-rich protein NP_828477.1 8707659 R 227882 CDS NP_828478.1 29833844 1217446 8708539..8709492 1 NC_003155.4 PF03640: repeat of unknown function; lipoprotein 8709492 1217446 SAV_7302 Streptomyces avermitilis MA-4680 lipoprotein NP_828478.1 8708539 D 227882 CDS NP_828479.1 29833845 1217447 8709840..8710652 1 NC_003155.4 PF04672: Protein of unknown function (DUF574); hypothetical protein 8710652 1217447 SAV_7303 Streptomyces avermitilis MA-4680 hypothetical protein NP_828479.1 8709840 D 227882 CDS NP_828480.1 29833846 1217448 8710649..8712802 1 NC_003155.4 PF00563: EAL domain, PF00990: GGDEF domain, PF00785: PAC motif; hypothetical protein 8712802 1217448 SAV_7304 Streptomyces avermitilis MA-4680 hypothetical protein NP_828480.1 8710649 D 227882 CDS NP_828481.1 29833847 1217449 8713321..8714100 1 NC_003155.4 PF00106: short chain dehydrogenase; dehydrogenase 8714100 1217449 SAV_7305 Streptomyces avermitilis MA-4680 dehydrogenase NP_828481.1 8713321 D 227882 CDS NP_828482.1 29833848 1217450 complement(8714200..8715093) 1 NC_003155.4 LysR family transcriptional regulator 8715093 1217450 SAV_7306 Streptomyces avermitilis MA-4680 LysR family transcriptional regulator NP_828482.1 8714200 R 227882 CDS NP_828483.1 29833849 1211714 8715169..8715876 1 NC_003155.4 cytochrome b subunit 8715876 qcrB2 1211714 qcrB2 Streptomyces avermitilis MA-4680 cytochrome b subunit NP_828483.1 8715169 D 227882 CDS NP_828484.1 29833850 1211715 8715880..8717829 1 NC_003155.4 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 8717829 sdhA 1211715 sdhA Streptomyces avermitilis MA-4680 succinate dehydrogenase flavoprotein subunit NP_828484.1 8715880 D 227882 CDS NP_828485.1 29833851 1211716 8717826..8718575 1 NC_003155.4 catalyzes the reversible formation of fumarate and ubiquinol from succinate and ubiquinone; succinate dehydrogenase/fumarate reductase iron-sulfur subunit 8718575 sdhB3 1211716 sdhB3 Streptomyces avermitilis MA-4680 succinate dehydrogenase/fumarate reductase iron-sulfur subunit NP_828485.1 8717826 D 227882 CDS NP_828486.1 29833852 1217451 8718965..8719735 1 NC_003155.4 hypothetical protein 8719735 1217451 SAV_7310 Streptomyces avermitilis MA-4680 hypothetical protein NP_828486.1 8718965 D 227882 CDS NP_828487.1 29833853 1211717 8719984..8720883 1 NC_003155.4 1-acylglycerol-3-phosphate O-acyltransferase 8720883 plsC7 1211717 plsC7 Streptomyces avermitilis MA-4680 1-acylglycerol-3-phosphate O-acyltransferase NP_828487.1 8719984 D 227882 CDS NP_828488.1 29833854 1217452 complement(8721019..8723946) 1 NC_003155.4 hypothetical protein 8723946 1217452 SAV_7312 Streptomyces avermitilis MA-4680 hypothetical protein NP_828488.1 8721019 R 227882 CDS NP_828489.1 29833855 1217453 8724575..8725219 1 NC_003155.4 hypothetical protein 8725219 1217453 SAV_7313 Streptomyces avermitilis MA-4680 hypothetical protein NP_828489.1 8724575 D 227882 CDS NP_828490.1 29833856 1217454 8725402..8726760 1 NC_003155.4 PF00657: GDSL-like Lipase/Acylhydrolase; hypothetical protein 8726760 1217454 SAV_7314 Streptomyces avermitilis MA-4680 hypothetical protein NP_828490.1 8725402 D 227882 CDS NP_828491.1 29833857 1217455 complement(8726798..8727028) 1 NC_003155.4 hypothetical protein 8727028 1217455 SAV_7315 Streptomyces avermitilis MA-4680 hypothetical protein NP_828491.1 8726798 R 227882 CDS NP_828492.1 29833858 1217456 complement(8727109..8727753) 1 NC_003155.4 methyltransferase 8727753 1217456 SAV_7316 Streptomyces avermitilis MA-4680 methyltransferase NP_828492.1 8727109 R 227882 CDS NP_828493.1 29833859 1217457 8727769..8728572 1 NC_003155.4 hypothetical protein 8728572 1217457 SAV_7317 Streptomyces avermitilis MA-4680 hypothetical protein NP_828493.1 8727769 D 227882 CDS NP_828494.1 29833860 1217458 complement(8728594..8729601) 1 NC_003155.4 oxygenase 8729601 1217458 SAV_7318 Streptomyces avermitilis MA-4680 oxygenase NP_828494.1 8728594 R 227882 CDS NP_828495.1 29833861 1217459 complement(8729675..8730427) 1 NC_003155.4 iron-sulfur protein 8730427 1217459 SAV_7319 Streptomyces avermitilis MA-4680 iron-sulfur protein NP_828495.1 8729675 R 227882 CDS NP_828496.1 29833862 1217460 8730975..8732147 1 NC_003155.4 probably siderophore biosynthesis protein; hypothetical protein 8732147 1217460 SAV_7320 Streptomyces avermitilis MA-4680 hypothetical protein NP_828496.1 8730975 D 227882 CDS NP_828497.1 29833863 1217461 8732144..8733907 1 NC_003155.4 probably siderophore biosynthesis protein, PF04183: IucA / IucC family; hypothetical protein 8733907 1217461 SAV_7321 Streptomyces avermitilis MA-4680 hypothetical protein NP_828497.1 8732144 D 227882 CDS NP_828498.1 29833864 1217462 8734011..8735816 1 NC_003155.4 PF04183: IucA / IucC family; iron transport protein 8735816 1217462 SAV_7322 Streptomyces avermitilis MA-4680 iron transport protein NP_828498.1 8734011 D 227882 CDS NP_828499.1 29833865 1217463 8735813..8737039 1 NC_003155.4 probably siderophore biosynthesis protein; diaminopimelate decarboxylase 8737039 1217463 SAV_7323 Streptomyces avermitilis MA-4680 diaminopimelate decarboxylase NP_828499.1 8735813 D 227882 CDS NP_828500.1 29833866 1217464 8737081..8739531 1 NC_003155.4 PF02518: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; magnesium or manganese-dependent protein phosphatase 8739531 prpL3 1217464 prpL3 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_828500.1 8737081 D 227882 CDS NP_828501.1 29833867 1217465 complement(8739584..8740081) 1 NC_003155.4 PF03992: Antibiotic biosynthesis monooxygenase; hypothetical protein 8740081 1217465 SAV_7325 Streptomyces avermitilis MA-4680 hypothetical protein NP_828501.1 8739584 R 227882 CDS NP_828502.1 29833868 1217466 8740090..8740746 1 NC_003155.4 transcriptional regulator 8740746 1217466 SAV_7326 Streptomyces avermitilis MA-4680 transcriptional regulator NP_828502.1 8740090 D 227882 CDS NP_828503.1 29833869 1217467 8740960..8741457 1 NC_003155.4 hypothetical protein 8741457 1217467 SAV_7327 Streptomyces avermitilis MA-4680 hypothetical protein NP_828503.1 8740960 D 227882 CDS NP_828504.1 29833870 1217468 complement(8741489..8741746) 1 NC_003155.4 PF07311: Protein of unknown function (DUF1458); hypothetical protein 8741746 1217468 SAV_7328 Streptomyces avermitilis MA-4680 hypothetical protein NP_828504.1 8741489 R 227882 CDS NP_828505.1 29833871 1217469 8741916..8743166 1 NC_003155.4 sugar transporter sugar binding protein 8743166 1217469 SAV_7329 Streptomyces avermitilis MA-4680 sugar transporter sugar binding protein NP_828505.1 8741916 D 227882 CDS NP_828506.1 29833872 1217470 complement(8743193..8745301) 1 NC_003155.4 PF01590: GAF domain; magnesium or manganese-dependent protein phosphatase 8745301 prpM5 1217470 prpM5 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_828506.1 8743193 R 227882 CDS NP_828507.1 29833873 1217471 8745511..8748213 1 NC_003155.4 LuxR family transcriptional regulator 8748213 1217471 SAV_7331 Streptomyces avermitilis MA-4680 LuxR family transcriptional regulator NP_828507.1 8745511 D 227882 CDS NP_828508.1 29833874 1217472 8748224..8750050 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane transport protein 8750050 1217472 SAV_7332 Streptomyces avermitilis MA-4680 transmembrane transport protein NP_828508.1 8748224 D 227882 CDS NP_828509.1 29833875 1217473 8750152..8750583 1 NC_003155.4 integral membrane protein 8750583 1217473 SAV_7333 Streptomyces avermitilis MA-4680 integral membrane protein NP_828509.1 8750152 D 227882 CDS NP_828510.1 29833876 1217474 8750726..8750923 1 NC_003155.4 hypothetical protein 8750923 1217474 SAV_7334 Streptomyces avermitilis MA-4680 hypothetical protein NP_828510.1 8750726 D 227882 CDS NP_828511.1 29833877 1217475 8751157..8751822 1 NC_003155.4 PF03729: Short repeat of unknown function (DUF308); integral membrane protein 8751822 1217475 SAV_7335 Streptomyces avermitilis MA-4680 integral membrane protein NP_828511.1 8751157 D 227882 CDS NP_828512.1 29833878 1217476 8751955..8752452 1 NC_003155.4 integral membrane protein 8752452 1217476 SAV_7336 Streptomyces avermitilis MA-4680 integral membrane protein NP_828512.1 8751955 D 227882 CDS NP_828513.1 29833879 1217477 8752486..8752932 1 NC_003155.4 integral membrane protein 8752932 1217477 SAV_7337 Streptomyces avermitilis MA-4680 integral membrane protein NP_828513.1 8752486 D 227882 CDS NP_828514.1 29833880 1217478 complement(8753067..8754068) 1 NC_003155.4 hypothetical protein 8754068 1217478 SAV_7338 Streptomyces avermitilis MA-4680 hypothetical protein NP_828514.1 8753067 R 227882 CDS NP_828515.1 29833881 1217479 complement(8754065..8754892) 1 NC_003155.4 PF02553: Cobalt transport protein component CbiN; hypothetical protein 8754892 1217479 SAV_7339 Streptomyces avermitilis MA-4680 hypothetical protein NP_828515.1 8754065 R 227882 CDS NP_828516.1 29833882 1217480 complement(8754892..8756214) 1 NC_003155.4 PF03781: Domain of unknown function (DUF323); hypothetical protein 8756214 1217480 SAV_7340 Streptomyces avermitilis MA-4680 hypothetical protein NP_828516.1 8754892 R 227882 CDS NP_828517.1 29833883 1217481 complement(8756211..8757485) 1 NC_003155.4 glutamate-cysteine ligase 8757485 gshA 1217481 gshA Streptomyces avermitilis MA-4680 glutamate-cysteine ligase NP_828517.1 8756211 R 227882 CDS NP_828518.1 29833884 1217482 8757636..8758619 1 NC_003155.4 hypothetical protein 8758619 1217482 SAV_7342 Streptomyces avermitilis MA-4680 hypothetical protein NP_828518.1 8757636 D 227882 CDS NP_828519.1 29833885 1217483 complement(8758604..8759059) 1 NC_003155.4 hypothetical protein 8759059 1217483 SAV_7343 Streptomyces avermitilis MA-4680 hypothetical protein NP_828519.1 8758604 R 227882 CDS NP_828520.1 29833886 1217484 complement(8759149..8760630) 1 NC_003155.4 PF01145: SPFH domain / Band 7 family; hypothetical protein 8760630 1217484 SAV_7344 Streptomyces avermitilis MA-4680 hypothetical protein NP_828520.1 8759149 R 227882 CDS NP_828521.1 29833887 1217485 complement(8760992..8762506) 1 NC_003155.4 catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; amidase 8762506 amiE2 1217485 amiE2 Streptomyces avermitilis MA-4680 amidase NP_828521.1 8760992 R 227882 CDS NP_828522.1 29833888 1217486 8762699..8763733 1 NC_003155.4 LacI family transcriptional regulator 8763733 1217486 SAV_7346 Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_828522.1 8762699 D 227882 CDS NP_828523.1 29833889 1211718 complement(8763919..8764308) 1 NC_003155.4 PF00085: Thioredoxin; thioredoxin 8764308 trxA3 1211718 trxA3 Streptomyces avermitilis MA-4680 thioredoxin NP_828523.1 8763919 R 227882 CDS NP_828524.1 29833890 1217487 8764437..8765870 1 NC_003155.4 similar to dihydrolipoamide dehydrogenase, PF00070: Pyridine nucleotide-disulphide oxidoreductase; oxidoreductase 8765870 lpdB2 1217487 lpdB2 Streptomyces avermitilis MA-4680 oxidoreductase NP_828524.1 8764437 D 227882 CDS NP_828525.1 29833891 1211719 complement(8766187..8766861) 1 NC_003155.4 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 8766861 def 1211719 def Streptomyces avermitilis MA-4680 peptide deformylase NP_828525.1 8766187 R 227882 CDS NP_828526.1 29833892 1217488 8767057..8768469 1 NC_003155.4 PF03929: Uncharacterized iron-regulated membrane protein (DUF337); integral membrane protein 8768469 1217488 SAV_7350 Streptomyces avermitilis MA-4680 integral membrane protein NP_828526.1 8767057 D 227882 CDS NP_828527.1 29833893 1217489 8768501..8768914 1 NC_003155.4 hypothetical protein 8768914 1217489 SAV_7351 Streptomyces avermitilis MA-4680 hypothetical protein NP_828527.1 8768501 D 227882 CDS NP_828528.1 29833894 1217490 complement(8769198..8769545) 1 NC_003155.4 hypothetical protein 8769545 1217490 SAV_7352 Streptomyces avermitilis MA-4680 hypothetical protein NP_828528.1 8769198 R 227882 CDS NP_828529.1 29833895 1217491 complement(8769623..8770087) 1 NC_003155.4 hypothetical protein 8770087 1217491 SAV_7353 Streptomyces avermitilis MA-4680 hypothetical protein NP_828529.1 8769623 R 227882 CDS NP_828530.1 29833896 1217492 complement(8770084..8770611) 1 NC_003155.4 similar to dihydrolipoamide dehydrogenase, PF00070: Pyridine nucleotide-disulphide oxidoreductase; MarR family transcriptional regulator 8770611 1217492 SAV_7354 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_828530.1 8770084 R 227882 CDS NP_828531.1 29833897 1217493 8770756..8771721 1 NC_003155.4 PF02678: Pirin; pirin-like protein 8771721 1217493 SAV_7355 Streptomyces avermitilis MA-4680 pirin-like protein NP_828531.1 8770756 D 227882 CDS NP_828532.1 29833898 1217494 complement(8772756..8773655) 1 NC_003155.4 truncated; monophenol monooxygenase 8773655 1217494 SAV_7356 Streptomyces avermitilis MA-4680 monophenol monooxygenase NP_828532.1 8772756 R 227882 CDS NP_828533.1 29833899 1217495 complement(8774009..8775772) 1 NC_003155.4 ABC transporter ATP-binding protein 8775772 1217495 SAV_7357 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_828533.1 8774009 R 227882 CDS NP_828534.1 29833900 1217496 complement(8775769..8776962) 1 NC_003155.4 PF04101: Glycosyltransferase family 28 C-terminal domain; glycosyl transferase 8776962 1217496 SAV_7358 Streptomyces avermitilis MA-4680 glycosyl transferase NP_828534.1 8775769 R 227882 CDS NP_828535.1 29833901 1217497 complement(8776963..8777766) 1 NC_003155.4 pks1 gene cluster, PF00561: alpha/beta hydrolase fold; hydrolase 8777766 1217497 SAV_7359 Streptomyces avermitilis MA-4680 hydrolase NP_828535.1 8776963 R 227882 CDS NP_828536.1 29833902 1217498 complement(8777769..8778044) 1 NC_003155.4 pks1 gene cluster; ACP 8778044 pks1-1 1217498 pks1-1 Streptomyces avermitilis MA-4680 ACP NP_828536.1 8777769 R 227882 CDS NP_828537.1 29833903 1217499 complement(8778095..8782666) 1 NC_003155.4 pks1 gene cluster; modular polyketide synthase 8782666 pks1-2 1217499 pks1-2 Streptomyces avermitilis MA-4680 modular polyketide synthase NP_828537.1 8778095 R 227882 CDS NP_828538.1 29833904 1217500 complement(8782669..8789766) 1 NC_003155.4 pks1 gene cluster; modular polyketide synthase 8789766 pks1-3 1217500 pks1-3 Streptomyces avermitilis MA-4680 modular polyketide synthase NP_828538.1 8782669 R 227882 CDS NP_828539.1 29833905 1211720 complement(8790510..8791988) 1 NC_003155.4 para-nitrobenzyl esterase 8791988 pnbA 1211720 pnbA Streptomyces avermitilis MA-4680 para-nitrobenzyl esterase NP_828539.1 8790510 R 227882 CDS NP_828540.1 29833906 1217501 complement(8792326..8792940) 1 NC_003155.4 hypothetical protein 8792940 1217501 SAV_7364 Streptomyces avermitilis MA-4680 hypothetical protein NP_828540.1 8792326 R 227882 CDS NP_828541.1 29833907 1217502 8793210..8795051 1 NC_003155.4 similar to HoxX protein; [NiFe] hydrogenase maturation 8795051 hypX 1217502 hypX Streptomyces avermitilis MA-4680 [NiFe] hydrogenase maturation NP_828541.1 8793210 D 227882 CDS NP_828542.1 29833908 1211721 8795100..8796188 1 NC_003155.4 PF01058: NADH ubiquinone oxidoreductase, 20 Kd subunit; cytochrome C3-like [NiFe] hydrogenase small subunit 8796188 hydA 1211721 hydA Streptomyces avermitilis MA-4680 cytochrome C3-like [NiFe] hydrogenase small subunit NP_828542.1 8795100 D 227882 CDS NP_828543.1 29833909 1211722 8796269..8798053 1 NC_003155.4 PF00374: Nickel-dependent hydrogenase; cytochrome C3-like [NiFe] hydrogenase large subunit 8798053 hydB 1211722 hydB Streptomyces avermitilis MA-4680 cytochrome C3-like [NiFe] hydrogenase large subunit NP_828543.1 8796269 D 227882 CDS NP_828544.1 29833910 1217503 8798050..8798640 1 NC_003155.4 similar to Ralstonia eutropha gi:38637731; hypothetical protein 8798640 1217503 SAV_7368 Streptomyces avermitilis MA-4680 hypothetical protein NP_828544.1 8798050 D 227882 CDS NP_828545.1 29833911 1217504 8798637..8799305 1 NC_003155.4 similar to Ralstonia eutropha gi:38637732; hypothetical protein 8799305 1217504 SAV_7369 Streptomyces avermitilis MA-4680 hypothetical protein NP_828545.1 8798637 D 227882 CDS NP_828546.1 29833912 1217505 8799302..8799994 1 NC_003155.4 similar to Ralstonia eutropha gi:38637733; hypothetical protein 8799994 1217505 SAV_7370 Streptomyces avermitilis MA-4680 hypothetical protein NP_828546.1 8799302 D 227882 CDS NP_828547.1 29833913 1217506 8799991..8801427 1 NC_003155.4 similar to Ralstonia eutropha gi:38637734; hypothetical protein 8801427 1217506 SAV_7371 Streptomyces avermitilis MA-4680 hypothetical protein NP_828547.1 8799991 D 227882 CDS NP_828548.1 29833914 1217507 8801424..8801975 1 NC_003155.4 similar to Ralstonia eutropha gi:38637735, PF01750: Hydrogenase maturation protease; [NiFe] hydrogenase-specific C-terminal protease 8801975 hupD 1217507 hupD Streptomyces avermitilis MA-4680 [NiFe] hydrogenase-specific C-terminal protease NP_828548.1 8801424 D 227882 CDS NP_828549.1 29833915 1211723 8802301..8802696 1 NC_003155.4 PF01155: Hydrogenase expression/synthesis hypA family; [NiFe] hydrogenase expression/formation protein 8802696 hypA 1211723 hypA Streptomyces avermitilis MA-4680 [NiFe] hydrogenase expression/formation protein NP_828549.1 8802301 D 227882 CDS NP_828550.1 29833916 1211724 8802700..8803527 1 NC_003155.4 PF02492: CobW/HypB/UreG, nucleotide-binding domain; [NiFe] hydrogenase expression/formation protein 8803527 hypB 1211724 hypB Streptomyces avermitilis MA-4680 [NiFe] hydrogenase expression/formation protein NP_828550.1 8802700 D 227882 CDS NP_828551.1 29833917 1211725 8803563..8805929 1 NC_003155.4 PF01300: yrdC domain; [NiFe] hydrogenase maturation protein 8805929 hypF 1211725 hypF Streptomyces avermitilis MA-4680 [NiFe] hydrogenase maturation protein NP_828551.1 8803563 D 227882 CDS NP_828552.1 29833918 1211726 8805990..8806310 1 NC_003155.4 PF01455: HupF/HypC family; [NiFe] hydrogenase expression/formation protein 8806310 hypC 1211726 hypC Streptomyces avermitilis MA-4680 [NiFe] hydrogenase expression/formation protein NP_828552.1 8805990 D 227882 CDS NP_828553.1 29833919 1211727 8806307..8807431 1 NC_003155.4 PF01924: Hydrogenase formation hypA family; [NiFe] hydrogenase expression/formation protein 8807431 hypD 1211727 hypD Streptomyces avermitilis MA-4680 [NiFe] hydrogenase expression/formation protein NP_828553.1 8806307 D 227882 CDS NP_828554.1 29833920 1211728 8807424..8808500 1 NC_003155.4 PF02769: AIR synthase related protein, C-terminal domain; [NiFe] hydrogenase expression/formation protein 8808500 hypE 1211728 hypE Streptomyces avermitilis MA-4680 [NiFe] hydrogenase expression/formation protein NP_828554.1 8807424 D 227882 CDS NP_828555.1 29833921 1217508 complement(8808563..8808949) 1 NC_003155.4 hypothetical protein 8808949 1217508 SAV_7379 Streptomyces avermitilis MA-4680 hypothetical protein NP_828555.1 8808563 R 227882 CDS NP_828556.1 29833922 1217509 complement(8809365..8809685) 1 NC_003155.4 hypothetical protein 8809685 1217509 SAV_7380 Streptomyces avermitilis MA-4680 hypothetical protein NP_828556.1 8809365 R 227882 CDS NP_828557.1 29833923 1217510 8809992..8810519 1 NC_003155.4 hypothetical protein 8810519 1217510 SAV_7381 Streptomyces avermitilis MA-4680 hypothetical protein NP_828557.1 8809992 D 227882 CDS NP_828558.1 29833924 1217511 8810525..8811163 1 NC_003155.4 PF01799: [2Fe-2S] binding domain; oxidoreductase iron-sulphur binding subunit 8811163 1217511 SAV_7382 Streptomyces avermitilis MA-4680 oxidoreductase iron-sulphur binding subunit NP_828558.1 8810525 D 227882 CDS NP_828559.1 29833925 1217512 8811160..8812152 1 NC_003155.4 PF00941: FAD binding domain in molybdopterin dehydrogenase; oxidoreductase molybdopterin binding subunit 8812152 1217512 SAV_7383 Streptomyces avermitilis MA-4680 oxidoreductase molybdopterin binding subunit NP_828559.1 8811160 D 227882 CDS NP_828560.1 29833926 1217513 8812222..8814342 1 NC_003155.4 PF02738: Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding domain; oxidoreductase 8814342 1217513 SAV_7384 Streptomyces avermitilis MA-4680 oxidoreductase NP_828560.1 8812222 D 227882 CDS NP_828561.1 29833927 1217514 8814519..8814695 1 NC_003155.4 hypothetical protein 8814695 1217514 SAV_7385 Streptomyces avermitilis MA-4680 hypothetical protein NP_828561.1 8814519 D 227882 CDS NP_828562.1 29833928 1217515 complement(8814779..8815009) 1 NC_003155.4 hypothetical protein 8815009 1217515 SAV_7386 Streptomyces avermitilis MA-4680 hypothetical protein NP_828562.1 8814779 R 227882 CDS NP_828563.1 29833929 1217516 8815160..8815735 1 NC_003155.4 PF02342: Bacterial stress protein; tellurium resistance protein 8815735 terD5 1217516 terD5 Streptomyces avermitilis MA-4680 tellurium resistance protein NP_828563.1 8815160 D 227882 CDS NP_828564.1 29833930 1217517 8815808..8816485 1 NC_003155.4 hypothetical protein 8816485 1217517 SAV_7388 Streptomyces avermitilis MA-4680 hypothetical protein NP_828564.1 8815808 D 227882 CDS NP_828565.1 29833931 1217518 complement(8816539..8817780) 1 NC_003155.4 PF00999: Sodium/hydrogen exchanger family; sodium/proton antiporter 8817780 1217518 SAV_7389 Streptomyces avermitilis MA-4680 sodium/proton antiporter NP_828565.1 8816539 R 227882 CDS NP_828566.1 29833932 1217519 complement(8817785..8818210) 1 NC_003155.4 PF02080: TrkA-C domain; hypothetical protein 8818210 1217519 SAV_7390 Streptomyces avermitilis MA-4680 hypothetical protein NP_828566.1 8817785 R 227882 CDS NP_828567.1 29833933 1217520 8818383..8819549 1 NC_003155.4 two-component system sensor kinase 8819549 1217520 SAV_7391 Streptomyces avermitilis MA-4680 two-component system sensor kinase NP_828567.1 8818383 D 227882 CDS NP_828568.1 29833934 1217521 8819549..8820220 1 NC_003155.4 two-component system response regulator 8820220 1217521 SAV_7392 Streptomyces avermitilis MA-4680 two-component system response regulator NP_828568.1 8819549 D 227882 CDS NP_828569.1 29833935 1217522 complement(8820563..8821054) 1 NC_003155.4 regulatory protein 8821054 1217522 SAV_7393 Streptomyces avermitilis MA-4680 regulatory protein NP_828569.1 8820563 R 227882 CDS NP_828570.1 29833936 1217523 8821348..8821674 1 NC_003155.4 hypothetical protein 8821674 1217523 SAV_7394 Streptomyces avermitilis MA-4680 hypothetical protein NP_828570.1 8821348 D 227882 CDS NP_828571.1 29833937 1211729 8821773..8823770 1 NC_003155.4 alpha-amylase 8823770 amyA5 1211729 amyA5 Streptomyces avermitilis MA-4680 alpha-amylase NP_828571.1 8821773 D 227882 CDS NP_828572.1 29833938 1211730 8823767..8825518 1 NC_003155.4 alpha-amylase family; trehalose synthase 8825518 treS2 1211730 treS2 Streptomyces avermitilis MA-4680 trehalose synthase NP_828572.1 8823767 D 227882 CDS NP_828573.1 29833939 1217524 8825547..8826941 1 NC_003155.4 pep2 protein 8826941 1217524 SAV_7397 Streptomyces avermitilis MA-4680 pep2 protein NP_828573.1 8825547 D 227882 CDS NP_828574.1 29833940 1217525 8826938..8827363 1 NC_003155.4 frameshift; glycogen branching enzyme 8827363 1217525 SAV_7398 Streptomyces avermitilis MA-4680 glycogen branching enzyme NP_828574.1 8826938 D 227882 CDS NP_828575.1 29833941 1217526 8827360..8829138 1 NC_003155.4 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme 8829138 1217526 SAV_7399 Streptomyces avermitilis MA-4680 glycogen branching enzyme NP_828575.1 8827360 D 227882 CDS NP_828576.1 29833942 1211731 8829444..8830238 1 NC_003155.4 RNA polymerase alternative sigma factor; RNA polymerase sigma factor 8830238 sig57 1211731 sig57 Streptomyces avermitilis MA-4680 RNA polymerase sigma factor NP_828576.1 8829444 D 227882 CDS NP_828577.1 29833943 1217527 complement(8830427..8830816) 1 NC_003155.4 PF03861: ANTAR domain; hypothetical protein 8830816 1217527 SAV_7401 Streptomyces avermitilis MA-4680 hypothetical protein NP_828577.1 8830427 R 227882 CDS NP_828578.1 29833944 1217528 8830948..8831559 1 NC_003155.4 PF03364: Streptomyces cyclase/dehydrase; cyclase/dehydrase 8831559 1217528 SAV_7402 Streptomyces avermitilis MA-4680 cyclase/dehydrase NP_828578.1 8830948 D 227882 CDS NP_828579.1 29833945 1217529 8831556..8832605 1 NC_003155.4 PF00296: Luciferase-like monooxygenase; FMN-dependent monooxygenase 8832605 1217529 SAV_7403 Streptomyces avermitilis MA-4680 FMN-dependent monooxygenase NP_828579.1 8831556 D 227882 CDS NP_828580.1 29833946 1217530 complement(8832701..8834011) 1 NC_003155.4 PF02687: Predicted permease; transmembrane transport protein 8834011 1217530 SAV_7404 Streptomyces avermitilis MA-4680 transmembrane transport protein NP_828580.1 8832701 R 227882 CDS NP_828581.1 29833947 1217531 complement(8834015..8834800) 1 NC_003155.4 ABC transporter ATP-binding protein 8834800 1217531 SAV_7405 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_828581.1 8834015 R 227882 CDS NP_828582.1 29833948 1217532 8834887..8835639 1 NC_003155.4 ABC transporter permease 8835639 1217532 SAV_7406 Streptomyces avermitilis MA-4680 ABC transporter permease NP_828582.1 8834887 D 227882 CDS NP_828583.1 29833949 1217533 8835636..8836307 1 NC_003155.4 ABC transporter permease 8836307 1217533 SAV_7407 Streptomyces avermitilis MA-4680 ABC transporter permease NP_828583.1 8835636 D 227882 CDS NP_828584.1 29833950 1217534 8836304..8837239 1 NC_003155.4 amino acid ABC transporter amino acid-binding protein 8837239 1217534 SAV_7408 Streptomyces avermitilis MA-4680 amino acid ABC transporter amino acid-binding protein NP_828584.1 8836304 D 227882 CDS NP_828585.1 29833951 1217535 complement(8837282..8838436) 1 NC_003155.4 ABC transporter ATP-binding protein 8838436 1217535 SAV_7409 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_828585.1 8837282 R 227882 CDS NP_828586.1 29833952 1217536 complement(8838469..8839164) 1 NC_003155.4 PF02589: Uncharacterized ACR, YkgG family COG1556; hypothetical protein 8839164 1217536 SAV_7410 Streptomyces avermitilis MA-4680 hypothetical protein NP_828586.1 8838469 R 227882 CDS NP_828587.1 29833953 1217537 complement(8839128..8840603) 1 NC_003155.4 iron-sulfur protein 8840603 1217537 SAV_7411 Streptomyces avermitilis MA-4680 iron-sulfur protein NP_828587.1 8839128 R 227882 CDS NP_828588.1 29833954 1217538 complement(8840600..8841355) 1 NC_003155.4 fumarate reductase-related protein 8841355 1217538 SAV_7412 Streptomyces avermitilis MA-4680 fumarate reductase-related protein NP_828588.1 8840600 R 227882 CDS NP_828589.1 29833955 1217539 complement(8841426..8842871) 1 NC_003155.4 rhamnulokinase 8842871 rhaB 1217539 rhaB Streptomyces avermitilis MA-4680 rhamnulokinase NP_828589.1 8841426 R 227882 CDS NP_828590.1 29833956 1211732 complement(8842868..8844907) 1 NC_003155.4 short chain dehydrogenase 8844907 srlD 1211732 srlD Streptomyces avermitilis MA-4680 short chain dehydrogenase NP_828590.1 8842868 R 227882 CDS NP_828591.1 29833957 1217540 complement(8845064..8846224) 1 NC_003155.4 sugar isomerase 8846224 1217540 SAV_7415 Streptomyces avermitilis MA-4680 sugar isomerase NP_828591.1 8845064 R 227882 CDS NP_828592.1 29833958 1217541 8846486..8848003 1 NC_003155.4 ABC transporter ATP-binding protein 8848003 1217541 SAV_7416 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_828592.1 8846486 D 227882 CDS NP_828593.1 29833959 1217542 8848059..8849099 1 NC_003155.4 ABC transporter permease 8849099 1217542 SAV_7417 Streptomyces avermitilis MA-4680 ABC transporter permease NP_828593.1 8848059 D 227882 CDS NP_828594.1 29833960 1217543 8849092..8850090 1 NC_003155.4 ABC transporter permease 8850090 1217543 SAV_7418 Streptomyces avermitilis MA-4680 ABC transporter permease NP_828594.1 8849092 D 227882 CDS NP_828595.1 29833961 1217544 8850119..8851201 1 NC_003155.4 solute-binding lipoprotein 8851201 1217544 SAV_7419 Streptomyces avermitilis MA-4680 solute-binding lipoprotein NP_828595.1 8850119 D 227882 CDS NP_828596.1 29833962 1217545 8851228..8851539 1 NC_003155.4 PF05336: Protein of unknown function (DUF718); hypothetical protein 8851539 1217545 SAV_7420 Streptomyces avermitilis MA-4680 hypothetical protein NP_828596.1 8851228 D 227882 CDS NP_828597.1 29833963 1217546 8851550..8852962 1 NC_003155.4 hypothetical protein 8852962 1217546 SAV_7421 Streptomyces avermitilis MA-4680 hypothetical protein NP_828597.1 8851550 D 227882 CDS NP_828598.1 29833964 1217547 8853042..8854067 1 NC_003155.4 LacI family transcriptional regulator 8854067 1217547 SAV_7422 Streptomyces avermitilis MA-4680 LacI family transcriptional regulator NP_828598.1 8853042 D 227882 CDS NP_828599.1 29833965 1217548 8854146..8855498 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; prolyl aminopeptidase 8855498 1217548 SAV_7423 Streptomyces avermitilis MA-4680 prolyl aminopeptidase NP_828599.1 8854146 D 227882 CDS NP_828600.1 29833966 1211733 8855573..8856541 1 NC_003155.4 ECF subfamily RNA polymerase sigma factor 8856541 sig58 1211733 sig58 Streptomyces avermitilis MA-4680 ECF subfamily RNA polymerase sigma factor NP_828600.1 8855573 D 227882 CDS NP_828601.1 29833967 1217549 8856821..8857651 1 NC_003155.4 PF00805: Pentapeptide repeats (8 copies); hypothetical protein 8857651 1217549 SAV_7425 Streptomyces avermitilis MA-4680 hypothetical protein NP_828601.1 8856821 D 227882 CDS NP_828602.1 29833968 1211734 complement(8857613..8859127) 1 NC_003155.4 CYP102B2; cytochrome P450 8859127 cyp27 1211734 cyp27 Streptomyces avermitilis MA-4680 cytochrome P450 NP_828602.1 8857613 R 227882 CDS NP_828603.1 29833969 1217550 8859236..8859844 1 NC_003155.4 TetR family transcriptional regulator 8859844 1217550 SAV_7427 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_828603.1 8859236 D 227882 CDS NP_828604.1 29833970 1217551 8859930..8860658 1 NC_003155.4 hypothetical protein 8860658 1217551 SAV_7428 Streptomyces avermitilis MA-4680 hypothetical protein NP_828604.1 8859930 D 227882 CDS NP_828605.1 29833971 1217552 complement(8860626..8861852) 1 NC_003155.4 hypothetical protein 8861852 1217552 SAV_7429 Streptomyces avermitilis MA-4680 hypothetical protein NP_828605.1 8860626 R 227882 CDS NP_828606.1 29833972 1217553 complement(8861978..8863036) 1 NC_003155.4 integral membrane protein 8863036 1217553 SAV_7430 Streptomyces avermitilis MA-4680 integral membrane protein NP_828606.1 8861978 R 227882 CDS NP_828607.1 29833973 1217554 complement(8863085..8864338) 1 NC_003155.4 PF06081: Bacterial protein of unknown function (DUF939); integral membrane protein 8864338 1217554 SAV_7431 Streptomyces avermitilis MA-4680 integral membrane protein NP_828607.1 8863085 R 227882 CDS NP_828608.1 29833974 1217555 complement(8864603..8865010) 1 NC_003155.4 hypothetical protein 8865010 1217555 SAV_7432 Streptomyces avermitilis MA-4680 hypothetical protein NP_828608.1 8864603 R 227882 CDS NP_828609.1 29833975 1217556 8865143..8866588 1 NC_003155.4 PF05139: Erythromycin esterase; hypothetical protein 8866588 1217556 SAV_7433 Streptomyces avermitilis MA-4680 hypothetical protein NP_828609.1 8865143 D 227882 CDS NP_828610.1 29833976 1217557 complement(8866617..8867105) 1 NC_003155.4 hypothetical protein 8867105 1217557 SAV_7434 Streptomyces avermitilis MA-4680 hypothetical protein NP_828610.1 8866617 R 227882 CDS NP_828611.1 29833977 1217558 complement(8867219..8867482) 1 NC_003155.4 hypothetical protein 8867482 1217558 SAV_7435 Streptomyces avermitilis MA-4680 hypothetical protein NP_828611.1 8867219 R 227882 CDS NP_828612.1 29833978 1217559 8867539..8868828 1 NC_003155.4 transcriptional regulator 8868828 1217559 SAV_7436 Streptomyces avermitilis MA-4680 transcriptional regulator NP_828612.1 8867539 D 227882 CDS NP_828613.1 29833979 1217560 8868940..8869275 1 NC_003155.4 hypothetical protein 8869275 1217560 SAV_7437 Streptomyces avermitilis MA-4680 hypothetical protein NP_828613.1 8868940 D 227882 CDS NP_828614.1 29833980 1217561 complement(8869571..8870539) 1 NC_003155.4 PF00106: short chain dehydrogenase; oxidoreductase 8870539 1217561 SAV_7438 Streptomyces avermitilis MA-4680 oxidoreductase NP_828614.1 8869571 R 227882 CDS NP_828615.1 29833981 1217562 complement(8870855..8871520) 1 NC_003155.4 PF00702: haloacid dehalogenase-like hydrolase; hydrolase 8871520 1217562 SAV_7439 Streptomyces avermitilis MA-4680 hydrolase NP_828615.1 8870855 R 227882 CDS NP_828616.1 29833982 1217563 complement(8871561..8872604) 1 NC_003155.4 PF02231: PHP domain N-terminal region; hypothetical protein 8872604 1217563 SAV_7440 Streptomyces avermitilis MA-4680 hypothetical protein NP_828616.1 8871561 R 227882 CDS NP_828617.1 29833983 1217564 8872829..8873065 1 NC_003155.4 hypothetical protein 8873065 1217564 SAV_7441 Streptomyces avermitilis MA-4680 hypothetical protein NP_828617.1 8872829 D 227882 CDS NP_828618.1 29833984 1217565 complement(8873224..8874486) 1 NC_003155.4 endo-1,3-beta-glucanase 8874486 lamA2 1217565 lamA2 Streptomyces avermitilis MA-4680 endo-1,3-beta-glucanase NP_828618.1 8873224 R 227882 CDS NP_828619.1 29833985 1217566 complement(8874615..8875205) 1 NC_003155.4 PF04892: VanZ like family; integral membrane protein 8875205 1217566 SAV_7443 Streptomyces avermitilis MA-4680 integral membrane protein NP_828619.1 8874615 R 227882 CDS NP_828620.1 29833986 1217567 8875490..8876074 1 NC_003155.4 PF04066: Multiple resistance and pH regulation protein F (MrpF / PhaF); hypothetical protein 8876074 1217567 SAV_7444 Streptomyces avermitilis MA-4680 hypothetical protein NP_828620.1 8875490 D 227882 CDS NP_828621.1 29833987 1217568 8876067..8876342 1 NC_003155.4 hypothetical protein 8876342 1217568 SAV_7445 Streptomyces avermitilis MA-4680 hypothetical protein NP_828621.1 8876067 D 227882 CDS NP_828622.1 29833988 1217569 8876339..8877079 1 NC_003155.4 PF04039: Domain related to MnhB subunit of Na+/H+ antiporter; hypothetical protein 8877079 1217569 SAV_7446 Streptomyces avermitilis MA-4680 hypothetical protein NP_828622.1 8876339 D 227882 CDS NP_828623.1 29833989 1217570 8877195..8877545 1 NC_003155.4 PF00420: NADH-ubiquinone/plastoquinone oxidore; dehydrogenase 8877545 1217570 SAV_7447 Streptomyces avermitilis MA-4680 dehydrogenase NP_828623.1 8877195 D 227882 CDS NP_828624.1 29833990 1217571 8877545..8879302 1 NC_003155.4 PF00361: NADH-Ubiquinone/plastoquinone (complex I), various chains; NADH-dehydrogenase 8879302 mrpD 1217571 mrpD Streptomyces avermitilis MA-4680 NADH-dehydrogenase NP_828624.1 8877545 D 227882 CDS NP_828625.1 29833991 1217572 complement(8879321..8880004) 1 NC_003155.4 protein 8880004 1217572 SAV_7449 Streptomyces avermitilis MA-4680 protein NP_828625.1 8879321 R 227882 CDS NP_828626.1 29833992 1217573 complement(8880199..8880600) 1 NC_003155.4 PF00009: Elongation factor Tu GTP binding domain; hypothetical protein 8880600 1217573 SAV_7450 Streptomyces avermitilis MA-4680 hypothetical protein NP_828626.1 8880199 R 227882 CDS NP_828627.1 29833993 1211735 8880691..8881644 1 NC_003155.4 ribose-phosphate pyrophosphokinase 8881644 prsA2 1211735 prsA2 Streptomyces avermitilis MA-4680 ribose-phosphate pyrophosphokinase NP_828627.1 8880691 D 227882 CDS NP_828628.1 29833994 1217574 complement(8881791..8882198) 1 NC_003155.4 PF01740: STAS domain; anti-sigma factor antagonist 8882198 1217574 SAV_7452 Streptomyces avermitilis MA-4680 anti-sigma factor antagonist NP_828628.1 8881791 R 227882 CDS NP_828629.1 29833995 1217575 complement(8882837..8883784) 1 NC_003155.4 PF00107: Zinc-binding dehydrogenase; dehydrogenase 8883784 1217575 SAV_7453 Streptomyces avermitilis MA-4680 dehydrogenase NP_828629.1 8882837 R 227882 CDS NP_828630.1 29833996 1217576 8883856..8884803 1 NC_003155.4 AraC family transcription regulator 8884803 1217576 SAV_7454 Streptomyces avermitilis MA-4680 AraC family transcription regulator NP_828630.1 8883856 D 227882 CDS NP_828631.1 29833997 1217577 complement(8884951..8885655) 1 NC_003155.4 esterase 8885655 1217577 SAV_7455 Streptomyces avermitilis MA-4680 esterase NP_828631.1 8884951 R 227882 CDS NP_828632.1 29833998 1217578 8885753..8886658 1 NC_003155.4 hypothetical protein 8886658 1217578 SAV_7456 Streptomyces avermitilis MA-4680 hypothetical protein NP_828632.1 8885753 D 227882 CDS NP_828633.1 29833999 1217579 complement(8886674..8887237) 1 NC_003155.4 TetR family transcriptional regulator 8887237 1217579 SAV_7457 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_828633.1 8886674 R 227882 CDS NP_828634.1 29834000 1217580 complement(8887243..8887605) 1 NC_003155.4 PF06993: Protein of unknown function (DUF1304); hypothetical protein 8887605 1217580 SAV_7458 Streptomyces avermitilis MA-4680 hypothetical protein NP_828634.1 8887243 R 227882 CDS NP_828635.1 29834001 1217581 8887817..8889352 1 NC_003155.4 membrane-associated oxidoreductase 8889352 1217581 SAV_7459 Streptomyces avermitilis MA-4680 membrane-associated oxidoreductase NP_828635.1 8887817 D 227882 CDS NP_828636.1 29834002 1217582 8889484..8889948 1 NC_003155.4 PF01243: Pyridoxamine 5'-phosphate oxidase; hypothetical protein 8889948 1217582 SAV_7460 Streptomyces avermitilis MA-4680 hypothetical protein NP_828636.1 8889484 D 227882 CDS NP_828637.1 29834003 1217583 8890031..8890423 1 NC_003155.4 PF00903: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; hypothetical protein 8890423 1217583 SAV_7461 Streptomyces avermitilis MA-4680 hypothetical protein NP_828637.1 8890031 D 227882 CDS NP_828638.1 29834004 1217584 complement(8890451..8890759) 1 NC_003155.4 hypothetical protein 8890759 1217584 SAV_7462 Streptomyces avermitilis MA-4680 hypothetical protein NP_828638.1 8890451 R 227882 CDS NP_828639.1 29834005 1217585 complement(8890796..8891812) 1 NC_003155.4 PF00043: Glutathione S-transferase, C-terminal domain; glutathione S-transferase 8891812 1217585 SAV_7463 Streptomyces avermitilis MA-4680 glutathione S-transferase NP_828639.1 8890796 R 227882 CDS NP_828640.1 29834006 1217586 8891921..8892991 1 NC_003155.4 PF01545: Cation efflux family; transport protein 8892991 1217586 SAV_7464 Streptomyces avermitilis MA-4680 transport protein NP_828640.1 8891921 D 227882 CDS NP_828641.1 29834007 1217587 complement(8893156..8893599) 1 NC_003155.4 PF04075: Domain of unknown function (DUF385); hypothetical protein 8893599 1217587 SAV_7465 Streptomyces avermitilis MA-4680 hypothetical protein NP_828641.1 8893156 R 227882 CDS NP_828642.1 29834008 1217588 complement(8893764..8894396) 1 NC_003155.4 PF01810: LysE type translocator; hypothetical protein 8894396 1217588 SAV_7466 Streptomyces avermitilis MA-4680 hypothetical protein NP_828642.1 8893764 R 227882 CDS NP_828643.1 29834009 1217589 complement(8894606..8895115) 1 NC_003155.4 PF00657: GDSL-like Lipase/Acylhydrolase; hypothetical protein 8895115 1217589 SAV_7467 Streptomyces avermitilis MA-4680 hypothetical protein NP_828643.1 8894606 R 227882 CDS NP_828644.1 29834010 1217590 8895148..8895834 1 NC_003155.4 hypothetical protein 8895834 1217590 SAV_7468 Streptomyces avermitilis MA-4680 hypothetical protein NP_828644.1 8895148 D 227882 CDS NP_828645.1 29834011 1211736 8895853..8897103 1 NC_003155.4 CYP105D7, fdxH is located at downstream; cytochrome P450 hydroxylase 8897103 cyp28 1211736 cyp28 Streptomyces avermitilis MA-4680 cytochrome P450 hydroxylase NP_828645.1 8895853 D 227882 CDS NP_828646.1 29834012 1211737 8897117..8897401 1 NC_003155.4 ferredoxin 8897401 fdxH 1211737 fdxH Streptomyces avermitilis MA-4680 ferredoxin NP_828646.1 8897117 D 227882 CDS NP_828647.1 29834013 1217591 complement(8897749..8898303) 1 NC_003155.4 TetR family transcriptional regulator 8898303 1217591 SAV_7471 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_828647.1 8897749 R 227882 CDS NP_828648.1 29834014 1217592 8898430..8898891 1 NC_003155.4 PF07080: Protein of unknown function (DUF1348); hypothetical protein 8898891 1217592 SAV_7472 Streptomyces avermitilis MA-4680 hypothetical protein NP_828648.1 8898430 D 227882 CDS NP_828649.1 29834015 1217593 8898901..8899431 1 NC_003155.4 possible flavoprotein involved in panthothenate metabolism; hypothetical protein 8899431 1217593 SAV_7473 Streptomyces avermitilis MA-4680 hypothetical protein NP_828649.1 8898901 D 227882 CDS NP_828650.1 29834016 1217594 complement(8899700..8900506) 1 NC_003155.4 hypothetical protein 8900506 1217594 SAV_7474 Streptomyces avermitilis MA-4680 hypothetical protein NP_828650.1 8899700 R 227882 CDS NP_828651.1 29834017 1217595 8900898..8901785 1 NC_003155.4 PF00561: alpha/beta hydrolase fold; hydrolase 8901785 1217595 SAV_7475 Streptomyces avermitilis MA-4680 hydrolase NP_828651.1 8900898 D 227882 CDS NP_828652.1 29834018 1217596 8902269..8905136 1 NC_003155.4 PF00652: QXW lectin repeat; hydrolase 8905136 1217596 SAV_7476 Streptomyces avermitilis MA-4680 hydrolase NP_828652.1 8902269 D 227882 CDS NP_828653.1 29834019 1217597 complement(8905145..8906488) 1 NC_003155.4 PF02040: Arsenical pump membrane protein; membrane efflux protein 8906488 arsB 1217597 arsB Streptomyces avermitilis MA-4680 membrane efflux protein NP_828653.1 8905145 R 227882 CDS NP_828654.1 29834020 1217598 complement(8906510..8908948) 1 NC_003155.4 PF01590: GAF domain; magnesium or manganese-dependent protein phosphatase 8908948 prpL4 1217598 prpL4 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_828654.1 8906510 R 227882 CDS NP_828655.1 29834021 1211738 8909193..8912285 1 NC_003155.4 beta-galactosidase precursor 8912285 bga8 1211738 bga8 Streptomyces avermitilis MA-4680 beta-galactosidase precursor NP_828655.1 8909193 D 227882 CDS NP_828656.1 29834022 1217599 8913182..8915059 1 NC_003155.4 PF00652: QXW lectin repeat; hydrolase 8915059 1217599 SAV_7480 Streptomyces avermitilis MA-4680 hydrolase NP_828656.1 8913182 D 227882 CDS NP_828657.1 29834023 1217600 complement(8915149..8916126) 1 NC_003155.4 PF02826: D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; phosphoglycerate dehydrogenase 8916126 1217600 SAV_7481 Streptomyces avermitilis MA-4680 phosphoglycerate dehydrogenase NP_828657.1 8915149 R 227882 CDS NP_828658.1 29834024 1211739 complement(8916123..8917292) 1 NC_003155.4 PF01070: FMN-dependent dehydrogenase; L-lactate 2-monooxygenase 8917292 lldA 1211739 lldA Streptomyces avermitilis MA-4680 L-lactate 2-monooxygenase NP_828658.1 8916123 R 227882 CDS NP_828659.1 29834025 1217601 complement(8917603..8918064) 1 NC_003155.4 PF01243: Pyridoxamine 5'-phosphate oxidase; hypothetical protein 8918064 1217601 SAV_7483 Streptomyces avermitilis MA-4680 hypothetical protein NP_828659.1 8917603 R 227882 CDS NP_828660.1 29834026 1217602 complement(8918174..8919001) 1 NC_003155.4 N5,N10- methylenetetrahydromethanopterin reductase-related protein 8919001 1217602 SAV_7484 Streptomyces avermitilis MA-4680 N5,N10- methylenetetrahydromethanopterin reductase-related protein NP_828660.1 8918174 R 227882 CDS NP_828661.1 29834027 1217603 complement(8919152..8919628) 1 NC_003155.4 hypothetical protein 8919628 1217603 SAV_7485 Streptomyces avermitilis MA-4680 hypothetical protein NP_828661.1 8919152 R 227882 CDS NP_828662.1 29834028 1211740 8920060..8920494 1 NC_003155.4 subtilase-type; inhibits bacterial serine proteases; protease inhibitor protein 8920494 sti2 1211740 sti2 Streptomyces avermitilis MA-4680 protease inhibitor protein NP_828662.1 8920060 D 227882 CDS NP_828663.1 29834029 1217604 complement(8920630..8920860) 1 NC_003155.4 hypothetical protein 8920860 1217604 SAV_7487 Streptomyces avermitilis MA-4680 hypothetical protein NP_828663.1 8920630 R 227882 CDS NP_828664.1 29834030 1217605 8921026..8921610 1 NC_003155.4 PF00583: Acetyltransferase (GNAT) family; hypothetical protein 8921610 1217605 SAV_7488 Streptomyces avermitilis MA-4680 hypothetical protein NP_828664.1 8921026 D 227882 CDS NP_828665.1 29834031 1217606 8921717..8923294 1 NC_003155.4 PF01569: PAP2 superfamily; hypothetical protein 8923294 1217606 SAV_7489 Streptomyces avermitilis MA-4680 hypothetical protein NP_828665.1 8921717 D 227882 CDS NP_828666.1 29834032 1217607 complement(8923302..8924804) 1 NC_003155.4 PF07690: Major Facilitator Superfamily; transmembrane efflux protein 8924804 1217607 SAV_7490 Streptomyces avermitilis MA-4680 transmembrane efflux protein NP_828666.1 8923302 R 227882 CDS NP_828667.1 29834033 1217608 8924911..8925477 1 NC_003155.4 PF05146: Aha1 domain; hypothetical protein 8925477 1217608 SAV_7491 Streptomyces avermitilis MA-4680 hypothetical protein NP_828667.1 8924911 D 227882 CDS NP_828668.1 29834034 1217609 complement(8925482..8928298) 1 NC_003155.4 ABC transporter ATP-binding protein 8928298 1217609 SAV_7492 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_828668.1 8925482 R 227882 CDS NP_828669.1 29834035 1217610 complement(8928300..8930549) 1 NC_003155.4 ABC transporter ATP-binding protein 8930549 1217610 SAV_7493 Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_828669.1 8928300 R 227882 CDS NP_828670.1 29834036 1217611 complement(8930534..8931340) 1 NC_003155.4 PF00364: Biotin-requiring enzyme; hypothetical protein 8931340 1217611 SAV_7494 Streptomyces avermitilis MA-4680 hypothetical protein NP_828670.1 8930534 R 227882 CDS NP_828671.1 29834037 1217612 complement(8931460..8931675) 1 NC_003155.4 hypothetical protein 8931675 1217612 SAV_7495 Streptomyces avermitilis MA-4680 hypothetical protein NP_828671.1 8931460 R 227882 CDS NP_828672.1 29834038 1217613 complement(8932137..8932577) 1 NC_003155.4 PF03061: Thioesterase superfamily; hypothetical protein 8932577 1217613 SAV_7496 Streptomyces avermitilis MA-4680 hypothetical protein NP_828672.1 8932137 R 227882 CDS NP_828673.1 29834039 1217614 8932746..8934104 1 NC_003155.4 PF02983: Alpha-lytic protease prodomain; protease precursor 8934104 1217614 SAV_7497 Streptomyces avermitilis MA-4680 protease precursor NP_828673.1 8932746 D 227882 CDS NP_828674.1 29834040 1217615 complement(8934191..8936329) 1 NC_003155.4 PF01590: GAF domain; magnesium or manganese-dependent protein phosphatase 8936329 prpJ8 1217615 prpJ8 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_828674.1 8934191 R 227882 CDS NP_828675.1 29834041 1211741 8936797..8937468 1 NC_003155.4 AmfR homolog protein; two-component system response regulator 8937468 amfR 1211741 amfR Streptomyces avermitilis MA-4680 two-component system response regulator NP_828675.1 8936797 D 227882 CDS NP_828676.1 29834042 1211742 complement(8937310..8939205) 1 NC_003155.4 AmfA/RamB homolog protein; ABC transporter ATP-binding protein 8939205 amfA 1211742 amfA Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_828676.1 8937310 R 227882 CDS NP_828677.1 29834043 1211743 complement(8939202..8940989) 1 NC_003155.4 AmfB/RamA homolog protein; ABC transporter ATP-binding protein 8940989 amfB 1211743 amfB Streptomyces avermitilis MA-4680 ABC transporter ATP-binding protein NP_828677.1 8939202 R 227882 CDS NP_828678.1 29834044 1211744 complement(8941080..8941196) 1 NC_003155.4 AmfS/RamS homolog protein; AmfS protein 8941196 amfS 1211744 amfS Streptomyces avermitilis MA-4680 AmfS protein NP_828678.1 8941080 R 227882 CDS NP_828679.1 29834045 1211745 complement(8941260..8943908) 1 NC_003155.4 AmfT homolog protein; membrane translocator 8943908 amfT 1211745 amfT Streptomyces avermitilis MA-4680 membrane translocator NP_828679.1 8941260 R 227882 CDS NP_828680.1 29834046 1217616 8944160..8946703 1 NC_003155.4 PF01590: GAF domain; magnesium or manganese-dependent protein phosphatase 8946703 prpC7 1217616 prpC7 Streptomyces avermitilis MA-4680 magnesium or manganese-dependent protein phosphatase NP_828680.1 8944160 D 227882 CDS NP_828681.1 29834047 1217617 8946807..8947310 1 NC_003155.4 PF00149: Calcineurin-like phosphoesterase; hypothetical protein 8947310 1217617 SAV_7505 Streptomyces avermitilis MA-4680 hypothetical protein NP_828681.1 8946807 D 227882 CDS NP_828682.1 29834048 1211746 complement(8947356..8948462) 1 NC_003155.4 xanthine dehydrogenase 8948462 pucA 1211746 pucA Streptomyces avermitilis MA-4680 xanthine dehydrogenase NP_828682.1 8947356 R 227882 CDS NP_828683.1 29834049 1211747 8948716..8950707 1 NC_003155.4 PF00009: Elongation factor Tu GTP binding domain; tetracycline resistance protein 8950707 tetM 1211747 tetM Streptomyces avermitilis MA-4680 tetracycline resistance protein NP_828683.1 8948716 D 227882 CDS NP_828684.1 29834050 1217618 8950741..8952684 1 NC_003155.4 PF00150: Cellulase (glycosyl hydrolase family 5); endoglycosylceramidase 8952684 1217618 SAV_7508 Streptomyces avermitilis MA-4680 endoglycosylceramidase NP_828684.1 8950741 D 227882 CDS NP_828685.1 29834051 1211748 complement(8952722..8953972) 1 NC_003155.4 serine/threonine protein kinase 8953972 pkn32 1211748 pkn32 Streptomyces avermitilis MA-4680 serine/threonine protein kinase NP_828685.1 8952722 R 227882 CDS NP_828686.1 29834052 1217619 8954182..8954841 1 NC_003155.4 TetR family transcriptional regulator 8954841 1217619 SAV_7510 Streptomyces avermitilis MA-4680 TetR family transcriptional regulator NP_828686.1 8954182 D 227882 CDS NP_828687.1 29834053 1217620 complement(8954887..8955165) 1 NC_003155.4 IS630 family; IS630 family transposase 8955165 1217620 SAV_7511 Streptomyces avermitilis MA-4680 IS630 family transposase NP_828687.1 8954887 R 227882 CDS NP_828688.1 29834054 1217621 complement(8955207..8956307) 1 NC_003155.4 IS110 family; IS110 family transposase 8956307 1217621 SAV_7512 Streptomyces avermitilis MA-4680 IS110 family transposase NP_828688.1 8955207 R 227882 CDS NP_828689.1 29834055 1217622 complement(8956405..8957319) 1 NC_003155.4 IS630 family, inserted IS900-like sequence. Inverted repeat sequence (11 bp). Target sequence (CTAG).; IS630 family transposase 8957319 1217622 SAV_7513 Streptomyces avermitilis MA-4680 IS630 family transposase NP_828689.1 8956405 R 227882 CDS NP_828690.1 29834056 1217623 complement(8957401..8958111) 1 NC_003155.4 WhiB-family transcriptional regulator 8958111 1217623 SAV_7514 Streptomyces avermitilis MA-4680 WhiB-family transcriptional regulator NP_828690.1 8957401 R 227882 CDS NP_828691.1 29834057 1217624 complement(8958230..8959000) 1 NC_003155.4 PF00990: GGDEF domain; hypothetical protein 8959000 1217624 SAV_7515 Streptomyces avermitilis MA-4680 hypothetical protein NP_828691.1 8958230 R 227882 CDS NP_828692.1 29834058 1211749 complement(8959331..8959792) 1 NC_003155.4 mobile element transfer protein SpdB 8959792 spdB3 1211749 spdB3 Streptomyces avermitilis MA-4680 mobile element transfer protein SpdB NP_828692.1 8959331 R 227882 CDS NP_828693.1 29834059 1217625 8960063..8960584 1 NC_003155.4 hypothetical protein 8960584 1217625 SAV_7517 Streptomyces avermitilis MA-4680 hypothetical protein NP_828693.1 8960063 D 227882 CDS NP_828694.1 29834060 1217626 complement(8960857..8961402) 1 NC_003155.4 hypothetical protein 8961402 1217626 SAV_7518 Streptomyces avermitilis MA-4680 hypothetical protein NP_828694.1 8960857 R 227882 CDS NP_828695.1 29834061 1217627 complement(8961788..8961976) 1 NC_003155.4 hypothetical protein 8961976 1217627 SAV_7519 Streptomyces avermitilis MA-4680 hypothetical protein NP_828695.1 8961788 R 227882 CDS NP_828696.1 29834062 1211750 complement(8962072..8964507) 1 NC_003155.4 ATP/GTP-binding; major plasmid transfer protein 8964507 traA2 1211750 traA2 Streptomyces avermitilis MA-4680 major plasmid transfer protein NP_828696.1 8962072 R 227882 CDS NP_828697.1 29834063 1211751 complement(8964610..8965014) 1 NC_003155.4 plasmid transfer protein 8965014 traB2 1211751 traB2 Streptomyces avermitilis MA-4680 plasmid transfer protein NP_828697.1 8964610 R 227882 CDS NP_828698.1 29834064 1217628 complement(8965030..8967180) 1 NC_003155.4 hypothetical protein 8967180 1217628 SAV_7522 Streptomyces avermitilis MA-4680 hypothetical protein NP_828698.1 8965030 R 227882 CDS NP_828699.1 29834065 1217629 complement(8967251..8967472) 1 NC_003155.4 hypothetical protein 8967472 1217629 SAV_7523 Streptomyces avermitilis MA-4680 hypothetical protein NP_828699.1 8967251 R 227882 CDS NP_828700.1 29834066 1217630 complement(8967472..8967978) 1 NC_003155.4 PF00823: PPE family; hypothetical protein 8967978 1217630 SAV_7524 Streptomyces avermitilis MA-4680 hypothetical protein NP_828700.1 8967472 R 227882 CDS NP_828701.1 29834067 1217631 complement(8968125..8969798) 1 NC_003155.4 PF06519: TolA protein; hypothetical protein 8969798 1217631 SAV_7525 Streptomyces avermitilis MA-4680 hypothetical protein NP_828701.1 8968125 R 227882 CDS NP_828702.1 29834068 1217632 complement(8969957..8970757) 1 NC_003155.4 hypothetical protein 8970757 1217632 SAV_7526 Streptomyces avermitilis MA-4680 hypothetical protein NP_828702.1 8969957 R 227882 CDS NP_828703.1 29834069 1217633 complement(8970898..8971074) 1 NC_003155.4 hypothetical protein 8971074 1217633 SAV_7527 Streptomyces avermitilis MA-4680 hypothetical protein NP_828703.1 8970898 R 227882 CDS NP_828704.1 29834070 1217634 complement(8971212..8971946) 1 NC_003155.4 hypothetical protein 8971946 1217634 SAV_7528 Streptomyces avermitilis MA-4680 hypothetical protein NP_828704.1 8971212 R 227882 CDS NP_828705.1 29834071 1217635 complement(8971904..8972464) 1 NC_003155.4 hypothetical protein 8972464 1217635 SAV_7529 Streptomyces avermitilis MA-4680 hypothetical protein NP_828705.1 8971904 R 227882 CDS NP_828706.1 29834072 1217636 8972843..8973172 1 NC_003155.4 PF03992: Antibiotic biosynthesis monooxygenase; hypothetical protein 8973172 1217636 SAV_7530 Streptomyces avermitilis MA-4680 hypothetical protein NP_828706.1 8972843 D 227882 CDS NP_828707.1 29834073 1217637 8973169..8974422 1 NC_003155.4 transcriptional regulator 8974422 1217637 SAV_7531 Streptomyces avermitilis MA-4680 transcriptional regulator NP_828707.1 8973169 D 227882 CDS NP_828708.1 29834074 1217638 8974593..8975660 1 NC_003155.4 P-loop ATPase 8975660 1217638 SAV_7532 Streptomyces avermitilis MA-4680 P-loop ATPase NP_828708.1 8974593 D 227882 CDS NP_828709.1 29834075 1217639 8975657..8976229 1 NC_003155.4 guanylate kinase 8976229 1217639 SAV_7533 Streptomyces avermitilis MA-4680 guanylate kinase NP_828709.1 8975657 D 227882 CDS NP_828710.1 29834076 1217640 complement(8976231..8977073) 1 NC_003155.4 PF02153: Prephenate dehydrogenase; hypothetical protein 8977073 1217640 SAV_7534 Streptomyces avermitilis MA-4680 hypothetical protein NP_828710.1 8976231 R 227882 CDS NP_828711.1 29834077 1217641 complement(8977078..8977725) 1 NC_003155.4 PF00702: haloacid dehalogenase-like hydrolase; hydrolase 8977725 1217641 SAV_7535 Streptomyces avermitilis MA-4680 hydrolase NP_828711.1 8977078 R 227882 CDS NP_828712.1 29834078 1217642 8978205..8981042 1 NC_003155.4 hypothetical protein 8981042 1217642 SAV_7536 Streptomyces avermitilis MA-4680 hypothetical protein NP_828712.1 8978205 D 227882 CDS NP_828713.1 29834079 1217643 complement(8984010..8985005) 1 NC_003155.4 hypothetical protein 8985005 1217643 SAV_7537 Streptomyces avermitilis MA-4680 hypothetical protein NP_828713.1 8984010 R 227882 CDS NP_828714.1 29834080 1217644 complement(8985002..8985670) 1 NC_003155.4 hypothetical protein 8985670 1217644 SAV_7538 Streptomyces avermitilis MA-4680 hypothetical protein NP_828714.1 8985002 R 227882 CDS NP_828715.1 29834081 1217645 complement(8985667..8986503) 1 NC_003155.4 hypothetical protein 8986503 1217645 SAV_7539 Streptomyces avermitilis MA-4680 hypothetical protein NP_828715.1 8985667 R 227882 CDS NP_828716.1 29834082 1217646 complement(8986500..8987678) 1 NC_003155.4 hypothetical protein 8987678 1217646 SAV_7540 Streptomyces avermitilis MA-4680 hypothetical protein NP_828716.1 8986500 R 227882 CDS NP_828717.1 29834083 1217647 complement(8987744..8988430) 1 NC_003155.4 hypothetical protein 8988430 1217647 SAV_7541 Streptomyces avermitilis MA-4680 hypothetical protein NP_828717.1 8987744 R 227882 CDS NP_828718.1 29834084 1217648 complement(8988473..8990044) 1 NC_003155.4 hypothetical protein 8990044 1217648 SAV_7542 Streptomyces avermitilis MA-4680 hypothetical protein NP_828718.1 8988473 R 227882 CDS NP_828719.1 29834085 1217649 complement(8990281..8993226) 1 NC_003155.4 helicase 8993226 1217649 SAV_7543 Streptomyces avermitilis MA-4680 helicase NP_828719.1 8990281 R 227882 CDS NP_828720.1 29834086 1217650 complement(8994124..8994972) 1 NC_003155.4 hypothetical protein 8994972 1217650 SAV_7544 Streptomyces avermitilis MA-4680 hypothetical protein NP_828720.1 8994124 R 227882 CDS NP_828721.1 29834087 1217651 8997081..8998715 1 NC_003155.4 IS6 family transposase 8998715 1217651 SAV_7545 Streptomyces avermitilis MA-4680 IS6 family transposase NP_828721.1 8997081 D 227882 CDS NP_828722.1 29834088 1217652 complement(8998805..8999614) 1 NC_003155.4 IS21 family, truncated; transposase 8999614 1217652 SAV_7546 Streptomyces avermitilis MA-4680 transposase NP_828722.1 8998805 R 227882 CDS NP_828723.1 29834089 1217653 complement(8999611..9000852) 1 NC_003155.4 IS21 family, truncated; IS21 family transposase 9000852 1217653 SAV_7547 Streptomyces avermitilis MA-4680 IS21 family transposase NP_828723.1 8999611 R 227882 CDS NP_828724.1 29834090 1217654 complement(9000969..9002603) 1 NC_003155.4 IS6 family transposase 9002603 1217654 SAV_7548 Streptomyces avermitilis MA-4680 IS6 family transposase NP_828724.1 9000969 R 227882 CDS NP_828725.1 29834091 1217655 complement(9002895..9003203) 1 NC_003155.4 hypothetical protein 9003203 1217655 SAV_7549 Streptomyces avermitilis MA-4680 hypothetical protein NP_828725.1 9002895 R 227882 CDS NP_828726.1 29834092 1217656 complement(9003252..9003410) 1 NC_003155.4 hypothetical protein 9003410 1217656 SAV_7551 Streptomyces avermitilis MA-4680 hypothetical protein NP_828726.1 9003252 R 227882 CDS NP_828727.1 29834093 1217657 9003392..9003574 1 NC_003155.4 hypothetical protein 9003574 1217657 SAV_7550 Streptomyces avermitilis MA-4680 hypothetical protein NP_828727.1 9003392 D 227882 CDS NP_828728.1 29834094 1217658 9003581..9004177 1 NC_003155.4 hypothetical protein 9004177 1217658 SAV_7552 Streptomyces avermitilis MA-4680 hypothetical protein NP_828728.1 9003581 D 227882 CDS NP_828729.1 29834095 1217659 9004239..9004721 1 NC_003155.4 IS1647-like transposase 9004721 1217659 SAV_7553 Streptomyces avermitilis MA-4680 IS1647-like transposase NP_828729.1 9004239 D 227882 CDS NP_828730.1 29834096 1217660 9004613..9005056 1 NC_003155.4 IS1647-like transposase 9005056 1217660 SAV_7554 Streptomyces avermitilis MA-4680 IS1647-like transposase NP_828730.1 9004613 D 227882 CDS NP_828731.1 29834097 1217661 9005159..9005944 1 NC_003155.4 hypothetical protein 9005944 1217661 SAV_7555 Streptomyces avermitilis MA-4680 hypothetical protein NP_828731.1 9005159 D 227882 CDS NP_828732.1 29834098 1217662 complement(9006357..9006758) 1 NC_003155.4 IS1648-like transposase 9006758 1217662 SAV_7556 Streptomyces avermitilis MA-4680 IS1648-like transposase NP_828732.1 9006357 R 227882 CDS NP_828733.1 29834099 1217663 9006906..9007151 1 NC_003155.4 hypothetical protein 9007151 1217663 SAV_7557 Streptomyces avermitilis MA-4680 hypothetical protein NP_828733.1 9006906 D 227882 CDS NP_828734.1 29834100 1217664 9007287..9008051 1 NC_003155.4 IS493-like transposase 9008051 1217664 SAV_7558 Streptomyces avermitilis MA-4680 IS493-like transposase NP_828734.1 9007287 D 227882 CDS NP_828735.1 29834101 1217665 9008121..9008366 1 NC_003155.4 hypothetical protein 9008366 1217665 SAV_7559 Streptomyces avermitilis MA-4680 hypothetical protein NP_828735.1 9008121 D 227882 CDS NP_828736.1 29834102 1217666 9008480..9008818 1 NC_003155.4 hypothetical protein 9008818 1217666 SAV_7560 Streptomyces avermitilis MA-4680 hypothetical protein NP_828736.1 9008480 D 227882 CDS NP_828737.1 29834103 1217667 complement(9009323..9012304) 1 NC_003155.4 PF05729: NACHT domain; hypothetical protein 9012304 1217667 SAV_7561 Streptomyces avermitilis MA-4680 hypothetical protein NP_828737.1 9009323 R 227882 CDS NP_828738.1 29834104 1217668 complement(9012343..9012708) 1 NC_003155.4 hypothetical protein 9012708 1217668 SAV_7562 Streptomyces avermitilis MA-4680 hypothetical protein NP_828738.1 9012343 R 227882 CDS NP_828739.1 29834105 1217669 complement(9012969..9013628) 1 NC_003155.4 PF00652: QXW lectin repeat; hypothetical protein 9013628 1217669 SAV_7563 Streptomyces avermitilis MA-4680 hypothetical protein NP_828739.1 9012969 R 227882 CDS NP_828740.1 29834106 1217670 9013686..9014216 1 NC_003155.4 hypothetical protein 9014216 1217670 SAV_7564 Streptomyces avermitilis MA-4680 hypothetical protein NP_828740.1 9013686 D 227882 CDS NP_828741.1 29834107 1217671 complement(9014686..9014829) 1 NC_003155.4 hypothetical protein 9014829 1217671 SAV_7565 Streptomyces avermitilis MA-4680 hypothetical protein NP_828741.1 9014686 R 227882 CDS NP_828742.1 29834108 1217672 complement(9015100..9015510) 1 NC_003155.4 hypothetical protein 9015510 1217672 SAV_7566 Streptomyces avermitilis MA-4680 hypothetical protein NP_828742.1 9015100 R 227882 CDS NP_828743.2 162960850 1211752 9015719..9017959 1 NC_003155.4 putative telomere-associated protein 9017959 tapA1 1211752 tapA1 Streptomyces avermitilis MA-4680 putative telomere-associated protein NP_828743.2 9015719 D 227882 CDS NP_828744.1 29834110 1211753 9017972..9018529 1 NC_003155.4 terminal protein TpgA1 9018529 tpgA1 1211753 tpgA1 Streptomyces avermitilis MA-4680 terminal protein TpgA1 NP_828744.1 9017972 D 227882 CDS NP_828745.1 29834111 1217673 complement(9019854..9020411) 1 NC_003155.4 IS630 family transposase 9020411 1217673 SAV_7569 Streptomyces avermitilis MA-4680 IS630 family transposase NP_828745.1 9019854 R 227882 CDS NP_828746.1 29834112 1217674 complement(9020408..9020947) 1 NC_003155.4 IS630 family transposase 9020947 1217674 SAV_7570 Streptomyces avermitilis MA-4680 IS630 family transposase NP_828746.1 9020408 R 227882 CDS NP_828747.1 29834113 1217675 complement(9021192..9023699) 1 NC_003155.4 helicase 9023699 1217675 SAV_7571 Streptomyces avermitilis MA-4680 helicase NP_828747.1 9021192 R 227882 CDS NP_828748.1 29834114 1217676 9023991..9024185 1 NC_003155.4 hypothetical protein 9024185 1217676 SAV_7572 Streptomyces avermitilis MA-4680 hypothetical protein NP_828748.1 9023991 D 227882 CDS NP_828749.1 29834115 1217677 9024130..9024540 1 NC_003155.4 hypothetical protein 9024540 1217677 SAV_7573 Streptomyces avermitilis MA-4680 hypothetical protein NP_828749.1 9024130 D 227882 CDS NP_828750.1 29826444 2746965 1197..1904 1 NC_004719.1 SAP1_1; hypothetical protein 1904 2746965 SAP1p01 Streptomyces avermitilis MA-4680 hypothetical protein NP_828750.1 1197 D 227882 CDS NP_828751.1 29826445 2746894 1901..2377 1 NC_004719.1 SAP1_2; hypothetical protein 2377 2746894 SAP1p02 Streptomyces avermitilis MA-4680 hypothetical protein NP_828751.1 1901 D 227882 CDS NP_828752.1 29826446 2746901 2490..2975 1 NC_004719.1 SAP1_3; hypothetical protein 2975 2746901 SAP1p03 Streptomyces avermitilis MA-4680 hypothetical protein NP_828752.1 2490 D 227882 CDS NP_828753.1 29826447 2746947 complement(4104..4619) 1 NC_004719.1 SAP1_4; hypothetical protein 4619 2746947 SAP1p04 Streptomyces avermitilis MA-4680 hypothetical protein NP_828753.1 4104 R 227882 CDS NP_828754.1 29826448 2746942 complement(4639..4911) 1 NC_004719.1 SAP1_5; hypothetical protein 4911 2746942 SAP1p05 Streptomyces avermitilis MA-4680 hypothetical protein NP_828754.1 4639 R 227882 CDS NP_828755.1 29826449 2746926 complement(4911..5144) 1 NC_004719.1 SAP1_6; hypothetical protein 5144 2746926 SAP1p06 Streptomyces avermitilis MA-4680 hypothetical protein NP_828755.1 4911 R 227882 CDS NP_828756.1 29826450 2746943 complement(6495..7088) 1 NC_004719.1 SAP1_7; hypothetical protein 7088 2746943 SAP1p07 Streptomyces avermitilis MA-4680 hypothetical protein NP_828756.1 6495 R 227882 CDS NP_828757.1 29826451 2746934 7111..7851 1 NC_004719.1 SAP1_8; putative transposase B-like protein 7851 2746934 SAP1p08 Streptomyces avermitilis MA-4680 putative transposase B-like protein NP_828757.1 7111 D 227882 CDS NP_828758.1 29826452 2746944 complement(8729..9040) 1 NC_004719.1 SAP1_9; hypothetical protein 9040 2746944 SAP1p09 Streptomyces avermitilis MA-4680 hypothetical protein NP_828758.1 8729 R 227882 CDS NP_828759.1 29826453 2746885 9260..9592 1 NC_004719.1 SAP1_10; hypothetical protein 9592 2746885 SAP1p10 Streptomyces avermitilis MA-4680 hypothetical protein NP_828759.1 9260 D 227882 CDS NP_828760.1 29826454 2746925 complement(9623..10216) 1 NC_004719.1 SAP1_11; hypothetical protein 10216 2746925 SAP1p11 Streptomyces avermitilis MA-4680 hypothetical protein NP_828760.1 9623 R 227882 CDS NP_828761.1 29826455 2746920 10346..10654 1 NC_004719.1 SAP1_12; hypothetical protein 10654 2746920 SAP1p12 Streptomyces avermitilis MA-4680 hypothetical protein NP_828761.1 10346 D 227882 CDS NP_828762.1 29826456 2746891 10741..11103 1 NC_004719.1 SAP1_13; hypothetical protein 11103 2746891 SAP1p13 Streptomyces avermitilis MA-4680 hypothetical protein NP_828762.1 10741 D 227882 CDS NP_828763.1 29826457 2746896 11106..11633 1 NC_004719.1 SAP1_14; hypothetical protein 11633 2746896 SAP1p14 Streptomyces avermitilis MA-4680 hypothetical protein NP_828763.1 11106 D 227882 CDS NP_828764.1 29826458 2746895 complement(11657..12223) 1 NC_004719.1 SAP1_15; hypothetical protein 12223 2746895 SAP1p15 Streptomyces avermitilis MA-4680 hypothetical protein NP_828764.1 11657 R 227882 CDS NP_828765.1 29826459 2746918 12286..13566 1 NC_004719.1 SAP1_16; putative endonuclease VII 13566 2746918 SAP1p16 Streptomyces avermitilis MA-4680 putative endonuclease VII NP_828765.1 12286 D 227882 CDS NP_828766.1 29826460 2746893 complement(13703..15061) 1 NC_004719.1 SAP1_17; hypothetical protein 15061 2746893 SAP1p17 Streptomyces avermitilis MA-4680 hypothetical protein NP_828766.1 13703 R 227882 CDS NP_828767.1 29826461 2746897 complement(15071..17104) 1 NC_004719.1 SAP1_18; putative NHN endonuclease 17104 2746897 SAP1p18 Streptomyces avermitilis MA-4680 putative NHN endonuclease NP_828767.1 15071 R 227882 CDS NP_828768.1 29826462 2746908 complement(17560..18426) 1 NC_004719.1 SAP1_19; putative acetyltransferase 18426 2746908 SAP1p19 Streptomyces avermitilis MA-4680 putative acetyltransferase NP_828768.1 17560 R 227882 CDS NP_828769.1 29826463 2746919 18796..19674 1 NC_004719.1 SAP1_20; hypothetical protein 19674 2746919 SAP1p20 Streptomyces avermitilis MA-4680 hypothetical protein NP_828769.1 18796 D 227882 CDS NP_828770.1 29826464 1210013 complement(19768..20325) 1 NC_004719.1 SAP1_21; putative terminal protein TpgA2 20325 tpgA2 1210013 tpgA2 Streptomyces avermitilis MA-4680 putative terminal protein TpgA2 NP_828770.1 19768 R 227882 CDS NP_828771.1 29826465 2746890 complement(20338..22656) 1 NC_004719.1 SAP1_22; putative transcriptional regulatory protein 22656 2746890 SAP1p22 Streptomyces avermitilis MA-4680 putative transcriptional regulatory protein NP_828771.1 20338 R 227882 CDS NP_828772.1 29826466 2746887 22760..24598 1 NC_004719.1 SAP1_23; putative DNA-binding protein 24598 2746887 SAP1p23 Streptomyces avermitilis MA-4680 putative DNA-binding protein NP_828772.1 22760 D 227882 CDS NP_828773.1 29826467 2746922 complement(24562..24840) 1 NC_004719.1 SAP1_24; hypothetical protein 24840 2746922 SAP1p24 Streptomyces avermitilis MA-4680 hypothetical protein NP_828773.1 24562 R 227882 CDS NP_828774.1 29826468 2746962 complement(24871..25902) 1 NC_004719.1 SAP1_25; hypothetical protein 25902 2746962 SAP1p25 Streptomyces avermitilis MA-4680 hypothetical protein NP_828774.1 24871 R 227882 CDS NP_828775.1 29826469 2746954 25942..28617 1 NC_004719.1 SAP1_26; putative DNA-binding protein 28617 2746954 SAP1p26 Streptomyces avermitilis MA-4680 putative DNA-binding protein NP_828775.1 25942 D 227882 CDS NP_828776.1 29826470 2746914 complement(28671..29051) 1 NC_004719.1 SAP1_27; hypothetical protein 29051 2746914 SAP1p27 Streptomyces avermitilis MA-4680 hypothetical protein NP_828776.1 28671 R 227882 CDS NP_828777.1 29826471 2746958 complement(29048..29407) 1 NC_004719.1 SAP1_28; hypothetical protein 29407 2746958 SAP1p28 Streptomyces avermitilis MA-4680 hypothetical protein NP_828777.1 29048 R 227882 CDS NP_828778.1 29826472 2746969 complement(29812..31962) 1 NC_004719.1 SAP1_29; hypothetical protein 31962 2746969 SAP1p29 Streptomyces avermitilis MA-4680 hypothetical protein NP_828778.1 29812 R 227882 CDS NP_828779.1 29826473 2746899 32033..32203 1 NC_004719.1 SAP1_30; hypothetical protein 32203 2746899 SAP1p30 Streptomyces avermitilis MA-4680 hypothetical protein NP_828779.1 32033 D 227882 CDS NP_828780.1 29826474 2746930 complement(32340..33533) 1 NC_004719.1 SAP1_31; putative serine/threonine protein kinase 33533 2746930 SAP1p31 Streptomyces avermitilis MA-4680 putative serine/threonine protein kinase NP_828780.1 32340 R 227882 CDS NP_828781.1 29826475 2746932 complement(33610..33942) 1 NC_004719.1 SAP1_32; putative Tra3 protein 33942 2746932 SAP1p32 Streptomyces avermitilis MA-4680 putative Tra3 protein NP_828781.1 33610 R 227882 CDS NP_828782.1 29826476 2746931 34010..37012 1 NC_004719.1 SAP1_33; hypothetical protein 37012 2746931 SAP1p33 Streptomyces avermitilis MA-4680 hypothetical protein NP_828782.1 34010 D 227882 CDS NP_828783.1 29826477 2746929 complement(37072..37557) 1 NC_004719.1 SAP1_34; putative Tra3-like protein 37557 2746929 SAP1p34 Streptomyces avermitilis MA-4680 putative Tra3-like protein NP_828783.1 37072 R 227882 CDS NP_828784.1 29826478 2746915 complement(37554..39374) 1 NC_004719.1 SAP1_35; hypothetical protein 39374 2746915 SAP1p35 Streptomyces avermitilis MA-4680 hypothetical protein NP_828784.1 37554 R 227882 CDS NP_828785.1 29826479 2746916 complement(40645..41325) 1 NC_004719.1 SAP1_36; putative riboflavin-specific deaminase/reductase 41325 2746916 SAP1p36 Streptomyces avermitilis MA-4680 putative riboflavin-specific deaminase/reductase NP_828785.1 40645 R 227882 CDS NP_828786.1 29826480 2746951 complement(41330..42763) 1 NC_004719.1 SAP1_37; putative DNA-binding protein 42763 2746951 SAP1p37 Streptomyces avermitilis MA-4680 putative DNA-binding protein NP_828786.1 41330 R 227882 CDS NP_828787.1 29826481 2746941 complement(42887..43690) 1 NC_004719.1 SAP1_38; GntR family transcriptional regulator 43690 2746941 SAP1p38 Streptomyces avermitilis MA-4680 GntR family transcriptional regulator NP_828787.1 42887 R 227882 CDS NP_828788.1 29826482 2746923 43843..44643 1 NC_004719.1 SAP1_39; hypothetical protein 44643 2746923 SAP1p39 Streptomyces avermitilis MA-4680 hypothetical protein NP_828788.1 43843 D 227882 CDS NP_828789.1 29826483 2746924 44778..45344 1 NC_004719.1 SAP1_40; putative regulatory protein 45344 2746924 SAP1p40 Streptomyces avermitilis MA-4680 putative regulatory protein NP_828789.1 44778 D 227882 CDS NP_828790.1 29826484 2746961 45428..45745 1 NC_004719.1 SAP1_41; putative regulatory protein 45745 2746961 SAP1p41 Streptomyces avermitilis MA-4680 putative regulatory protein NP_828790.1 45428 D 227882 CDS NP_828791.1 29826485 2746949 45889..46146 1 NC_004719.1 SAP1_42; hypothetical protein 46146 2746949 SAP1p42 Streptomyces avermitilis MA-4680 hypothetical protein NP_828791.1 45889 D 227882 CDS NP_828792.1 29826486 2746880 46230..46616 1 NC_004719.1 SAP1_43; hypothetical protein 46616 2746880 SAP1p43 Streptomyces avermitilis MA-4680 hypothetical protein NP_828792.1 46230 D 227882 CDS NP_828793.1 29826487 2746945 46672..48876 1 NC_004719.1 SAP1_44; putative large alanine-rich protein 48876 2746945 SAP1p44 Streptomyces avermitilis MA-4680 putative large alanine-rich protein NP_828793.1 46672 D 227882 CDS NP_828794.1 29826488 2746946 48992..49468 1 NC_004719.1 SAP1_45; hypothetical protein 49468 2746946 SAP1p45 Streptomyces avermitilis MA-4680 hypothetical protein NP_828794.1 48992 D 227882 CDS NP_828795.1 29826489 2746928 49465..49773 1 NC_004719.1 SAP1_46; hypothetical protein 49773 2746928 SAP1p46 Streptomyces avermitilis MA-4680 hypothetical protein NP_828795.1 49465 D 227882 CDS NP_828796.1 29826490 2746903 49901..52117 1 NC_004719.1 SAP1_47; putative ATP/GTP-binding Gly/Ala-rich protein 52117 2746903 SAP1p47 Streptomyces avermitilis MA-4680 putative ATP/GTP-binding Gly/Ala-rich protein NP_828796.1 49901 D 227882 CDS NP_828797.1 29826491 1210015 52137..52553 1 NC_004719.1 SAP1_48; putative TraB protein 52553 traB 1210015 traB Streptomyces avermitilis MA-4680 putative TraB protein NP_828797.1 52137 D 227882 CDS NP_828798.1 29826492 1210014 52635..54779 1 NC_004719.1 SAP1_49; putative TraA protein 54779 traA 1210014 traA Streptomyces avermitilis MA-4680 putative TraA protein NP_828798.1 52635 D 227882 CDS NP_828799.1 29826493 2746917 54860..55048 1 NC_004719.1 SAP1_50; hypothetical protein 55048 2746917 SAP1p50 Streptomyces avermitilis MA-4680 hypothetical protein NP_828799.1 54860 D 227882 CDS NP_828800.1 29826494 2746905 complement(55049..55303) 1 NC_004719.1 SAP1_51; hypothetical protein 55303 2746905 SAP1p51 Streptomyces avermitilis MA-4680 hypothetical protein NP_828800.1 55049 R 227882 CDS NP_828801.1 29826495 2746906 55435..55929 1 NC_004719.1 SAP1_52; hypothetical protein 55929 2746906 SAP1p52 Streptomyces avermitilis MA-4680 hypothetical protein NP_828801.1 55435 D 227882 CDS NP_828802.1 29826496 2746892 55992..56792 1 NC_004719.1 SAP1_53; hypothetical protein 56792 2746892 SAP1p53 Streptomyces avermitilis MA-4680 hypothetical protein NP_828802.1 55992 D 227882 CDS NP_828803.1 29826497 2746889 56873..57118 1 NC_004719.1 SAP1_54; hypothetical protein 57118 2746889 SAP1p54 Streptomyces avermitilis MA-4680 hypothetical protein NP_828803.1 56873 D 227882 CDS NP_828804.1 29826498 2746900 57364..57831 1 NC_004719.1 SAP1_55; hypothetical protein 57831 2746900 SAP1p55 Streptomyces avermitilis MA-4680 hypothetical protein NP_828804.1 57364 D 227882 CDS NP_828805.1 29826499 2746956 57828..58457 1 NC_004719.1 SAP1_56; hypothetical protein 58457 2746956 SAP1p56 Streptomyces avermitilis MA-4680 hypothetical protein NP_828805.1 57828 D 227882 CDS NP_828806.1 29826500 2746952 58454..58804 1 NC_004719.1 SAP1_57; hypothetical protein 58804 2746952 SAP1p57 Streptomyces avermitilis MA-4680 hypothetical protein NP_828806.1 58454 D 227882 CDS NP_828807.1 29826501 2746967 58801..59757 1 NC_004719.1 SAP1_58; putative ATP/GTP-binding protein 59757 2746967 SAP1p58 Streptomyces avermitilis MA-4680 putative ATP/GTP-binding protein NP_828807.1 58801 D 227882 CDS NP_828808.1 29826502 2746953 60014..60370 1 NC_004719.1 SAP1_59; hypothetical protein 60370 2746953 SAP1p59 Streptomyces avermitilis MA-4680 hypothetical protein NP_828808.1 60014 D 227882 CDS NP_828809.1 29826503 2746910 60537..60980 1 NC_004719.1 SAP1_60; hypothetical protein 60980 2746910 SAP1p60 Streptomyces avermitilis MA-4680 hypothetical protein NP_828809.1 60537 D 227882 CDS NP_828810.1 29826504 2746909 60977..61258 1 NC_004719.1 SAP1_61; hypothetical protein 61258 2746909 SAP1p61 Streptomyces avermitilis MA-4680 hypothetical protein NP_828810.1 60977 D 227882 CDS NP_828811.1 29826505 2746955 61281..61454 1 NC_004719.1 SAP1_62; hypothetical protein 61454 2746955 SAP1p62 Streptomyces avermitilis MA-4680 hypothetical protein NP_828811.1 61281 D 227882 CDS NP_828812.1 29826506 2746921 61468..62430 1 NC_004719.1 SAP1_63; hypothetical protein 62430 2746921 SAP1p63 Streptomyces avermitilis MA-4680 hypothetical protein NP_828812.1 61468 D 227882 CDS NP_828813.1 29826507 2746907 complement(62451..62912) 1 NC_004719.1 SAP1_64; putative acetyltransferase 62912 2746907 SAP1p64 Streptomyces avermitilis MA-4680 putative acetyltransferase NP_828813.1 62451 R 227882 CDS NP_828814.1 29826508 2746959 complement(63009..64202) 1 NC_004719.1 SAP1_65; IS116/IS110/IS902 family transposase 64202 2746959 SAP1p65 Streptomyces avermitilis MA-4680 IS116/IS110/IS902 family transposase NP_828814.1 63009 R 227882 CDS NP_828815.1 29826509 2746904 64439..65188 1 NC_004719.1 SAP1_66; hypothetical protein 65188 2746904 SAP1p66 Streptomyces avermitilis MA-4680 hypothetical protein NP_828815.1 64439 D 227882 CDS NP_828816.1 29826510 2746966 65221..65397 1 NC_004719.1 SAP1_67; hypothetical protein 65397 2746966 SAP1p67 Streptomyces avermitilis MA-4680 hypothetical protein NP_828816.1 65221 D 227882 CDS NP_828817.1 29826511 2746950 65485..65925 1 NC_004719.1 SAP1_68; hypothetical protein 65925 2746950 SAP1p68 Streptomyces avermitilis MA-4680 hypothetical protein NP_828817.1 65485 D 227882 CDS NP_828818.1 29826512 2746960 65922..66545 1 NC_004719.1 SAP1_69; hypothetical protein 66545 2746960 SAP1p69 Streptomyces avermitilis MA-4680 hypothetical protein NP_828818.1 65922 D 227882 CDS NP_828819.1 29826513 1210012 complement(66759..67790) 1 NC_004719.1 ParB nuclease; SAP1_70; putative plasmid partitioning protein 67790 parB 1210012 parB Streptomyces avermitilis MA-4680 putative plasmid partitioning protein NP_828819.1 66759 R 227882 CDS NP_828820.1 29826514 1210011 complement(67787..69070) 1 NC_004719.1 ParA ATPase; SAP1_71; putative plasmid partitioning protein 69070 parA 1210011 parA Streptomyces avermitilis MA-4680 putative plasmid partitioning protein NP_828820.1 67787 R 227882 CDS NP_828821.1 29826515 2746968 69221..70444 1 NC_004719.1 SAP1_72; hypothetical protein 70444 2746968 SAP1p72 Streptomyces avermitilis MA-4680 hypothetical protein NP_828821.1 69221 D 227882 CDS NP_828822.1 29826516 2746912 complement(70500..71348) 1 NC_004719.1 SAP1_73; hypothetical protein 71348 2746912 SAP1p73 Streptomyces avermitilis MA-4680 hypothetical protein NP_828822.1 70500 R 227882 CDS NP_828823.1 29826517 2746913 71473..72894 1 NC_004719.1 SAP1_74; hypothetical protein 72894 2746913 SAP1p74 Streptomyces avermitilis MA-4680 hypothetical protein NP_828823.1 71473 D 227882 CDS NP_828824.1 29826518 2746902 73370..75196 1 NC_004719.1 SAP1_75; putative TraA-like protein 75196 2746902 SAP1p75 Streptomyces avermitilis MA-4680 putative TraA-like protein NP_828824.1 73370 D 227882 CDS NP_828825.1 29826519 2746898 75193..75540 1 NC_004719.1 SAP1_76; hypothetical protein 75540 2746898 SAP1p76 Streptomyces avermitilis MA-4680 hypothetical protein NP_828825.1 75193 D 227882 CDS NP_828826.1 29826520 2746911 complement(75821..76372) 1 NC_004719.1 SAP1_77; MarR family transcriptional regulator 76372 2746911 SAP1p77 Streptomyces avermitilis MA-4680 MarR family transcriptional regulator NP_828826.1 75821 R 227882 CDS NP_828827.1 29826521 2746940 complement(76391..76693) 1 NC_004719.1 SAP1_78; hypothetical protein 76693 2746940 SAP1p78 Streptomyces avermitilis MA-4680 hypothetical protein NP_828827.1 76391 R 227882 CDS NP_828828.1 29826522 2746888 complement(77122..77331) 1 NC_004719.1 SAP1_79; hypothetical protein 77331 2746888 SAP1p79 Streptomyces avermitilis MA-4680 hypothetical protein NP_828828.1 77122 R 227882 CDS NP_828829.1 29826523 2746939 complement(77375..77812) 1 NC_004719.1 SAP1_80; hypothetical protein 77812 2746939 SAP1p80 Streptomyces avermitilis MA-4680 hypothetical protein NP_828829.1 77375 R 227882 CDS NP_828830.1 29826524 2746957 77865..78545 1 NC_004719.1 SAP1_81; hypothetical protein 78545 2746957 SAP1p81 Streptomyces avermitilis MA-4680 hypothetical protein NP_828830.1 77865 D 227882 CDS NP_828831.1 29826525 2746963 78662..79711 1 NC_004719.1 SAP1_82; hypothetical protein 79711 2746963 SAP1p82 Streptomyces avermitilis MA-4680 hypothetical protein NP_828831.1 78662 D 227882 CDS NP_828832.1 29826526 2746883 79927..80568 1 NC_004719.1 SAP1_83; hypothetical protein 80568 2746883 SAP1p83 Streptomyces avermitilis MA-4680 hypothetical protein NP_828832.1 79927 D 227882 CDS NP_828833.1 29826527 2746884 complement(80518..81579) 1 NC_004719.1 SAP1_84; hypothetical protein 81579 2746884 SAP1p84 Streptomyces avermitilis MA-4680 hypothetical protein NP_828833.1 80518 R 227882 CDS NP_828834.1 29826528 2746936 81600..81701 1 NC_004719.1 SAP1_85; hypothetical protein 81701 2746936 SAP1p85 Streptomyces avermitilis MA-4680 hypothetical protein NP_828834.1 81600 D 227882 CDS NP_828835.1 29826529 2746881 81711..81926 1 NC_004719.1 SAP1_86; hypothetical protein 81926 2746881 SAP1p86 Streptomyces avermitilis MA-4680 hypothetical protein NP_828835.1 81711 D 227882 CDS NP_828836.1 29826530 2746948 81923..82828 1 NC_004719.1 SAP1_87; putative RNA polymerase sigma factor 82828 2746948 SAP1p87 Streptomyces avermitilis MA-4680 putative RNA polymerase sigma factor NP_828836.1 81923 D 227882 CDS NP_828837.1 29826531 2746935 82825..83700 1 NC_004719.1 SAP1_88; hypothetical protein 83700 2746935 SAP1p88 Streptomyces avermitilis MA-4680 hypothetical protein NP_828837.1 82825 D 227882 CDS NP_828838.1 29826532 2746882 complement(83768..84670) 1 NC_004719.1 SAP1_89; hypothetical protein 84670 2746882 SAP1p89 Streptomyces avermitilis MA-4680 hypothetical protein NP_828838.1 83768 R 227882 CDS NP_828839.1 29826533 1210010 complement(85072..86049) 1 NC_004719.1 SAP1_90; putative ATP-dependint DNA ligase 86049 lig 1210010 lig Streptomyces avermitilis MA-4680 putative ATP-dependint DNA ligase NP_828839.1 85072 R 227882 CDS NP_828840.1 29826534 2746927 complement(86243..86371) 1 NC_004719.1 SAP1_91; hypothetical protein 86371 2746927 SAP1p91 Streptomyces avermitilis MA-4680 hypothetical protein NP_828840.1 86243 R 227882 CDS NP_828841.1 29826535 2746964 86514..87095 1 NC_004719.1 SAP1_92; hypothetical protein 87095 2746964 SAP1p92 Streptomyces avermitilis MA-4680 hypothetical protein NP_828841.1 86514 D 227882 CDS NP_828842.1 29826536 2746938 87433..89484 1 NC_004719.1 SAP1_93; putative DNA mismatch repair protein 89484 2746938 SAP1p93 Streptomyces avermitilis MA-4680 putative DNA mismatch repair protein NP_828842.1 87433 D 227882 CDS NP_828843.1 29826537 2746933 89669..90514 1 NC_004719.1 SAP1_94; putative dioxygenase 90514 2746933 SAP1p94 Streptomyces avermitilis MA-4680 putative dioxygenase NP_828843.1 89669 D 227882 CDS NP_828844.1 29826538 2746886 complement(90591..93248) 1 NC_004719.1 SAP1_95; putative helicase 93248 2746886 SAP1p95 Streptomyces avermitilis MA-4680 putative helicase NP_828844.1 90591 R 227882 CDS NP_828845.1 29826539 2746937 complement(93292..93669) 1 NC_004719.1 SAP1_96; hypothetical protein 93669 2746937 SAP1p96 Streptomyces avermitilis MA-4680 hypothetical protein NP_828845.1 93292 R 227882 CDS