-- dump date 20111121_015146 -- class Genbank::misc_feature -- table misc_feature_note -- id note 227882000001 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882000002 Recombination endonuclease VII; Region: Endonuclease_7; pfam02945 227882000003 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 227882000004 ATP binding site [chemical binding]; other site 227882000005 putative Mg++ binding site [ion binding]; other site 227882000006 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882000007 Helicase associated domain; Region: HA; pfam03457 227882000008 Helicase associated domain; Region: HA; pfam03457 227882000009 Helicase associated domain; Region: HA; pfam03457 227882000010 C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family include the bacteriophage lambda integrase, the...; Region: INT_REC_C; cd01182 227882000011 DNA binding site [nucleotide binding] 227882000012 Int/Topo IB signature motif; other site 227882000013 active site 227882000014 catalytic residues [active] 227882000015 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 227882000016 active site 227882000017 Int/Topo IB signature motif; other site 227882000018 Helicase associated domain; Region: HA; pfam03457 227882000019 Helicase associated domain; Region: HA; pfam03457 227882000020 Helicase associated domain; Region: HA; pfam03457 227882000021 NADH dehydrogenase subunit 2; Provisional; Region: ND2; MTH00199 227882000022 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 227882000023 RHS Repeat; Region: RHS_repeat; cl11982 227882000024 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 227882000025 RHS Repeat; Region: RHS_repeat; cl11982 227882000026 RHS Repeat; Region: RHS_repeat; cl11982 227882000027 RHS Repeat; Region: RHS_repeat; cl11982 227882000028 RHS Repeat; Region: RHS_repeat; cl11982 227882000029 RHS protein; Region: RHS; pfam03527 227882000030 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 227882000031 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 227882000032 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882000033 Helicase associated domain; Region: HA; pfam03457 227882000034 Helicase associated domain; Region: HA; pfam03457 227882000035 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882000036 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 227882000037 dimer interface [polypeptide binding]; other site 227882000038 phosphorylation site [posttranslational modification] 227882000039 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882000040 ATP binding site [chemical binding]; other site 227882000041 Mg2+ binding site [ion binding]; other site 227882000042 G-X-G motif; other site 227882000043 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882000044 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 227882000045 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 227882000046 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 227882000047 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882000048 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 227882000049 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 227882000050 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 227882000051 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 227882000052 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 227882000053 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 227882000054 Probable transposase; Region: OrfB_IS605; pfam01385 227882000055 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 227882000056 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 227882000057 nucleotide binding site/active site [active] 227882000058 HIT family signature motif; other site 227882000059 catalytic residue [active] 227882000060 Predicted membrane protein [Function unknown]; Region: COG1289 227882000061 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882000062 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882000063 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 227882000064 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 227882000065 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 227882000066 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 227882000067 Probable transposase; Region: OrfB_IS605; pfam01385 227882000068 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 227882000069 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 227882000070 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 227882000071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882000072 Probable transposase; Region: OrfB_IS605; pfam01385 227882000073 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 227882000074 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882000075 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 227882000076 putative hydrophobic ligand binding site [chemical binding]; other site 227882000077 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882000078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 227882000079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882000080 ATP binding site [chemical binding]; other site 227882000081 Mg2+ binding site [ion binding]; other site 227882000082 G-X-G motif; other site 227882000083 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 227882000084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882000085 active site 227882000086 phosphorylation site [posttranslational modification] 227882000087 intermolecular recognition site; other site 227882000088 dimerization interface [polypeptide binding]; other site 227882000089 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882000090 DNA binding site [nucleotide binding] 227882000091 Predicted membrane protein (DUF2079); Region: DUF2079; cl01374 227882000092 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 227882000093 homotrimer interaction site [polypeptide binding]; other site 227882000094 putative active site [active] 227882000095 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 227882000096 substrate binding pocket [chemical binding]; other site 227882000097 substrate-Mg2+ binding site; other site 227882000098 aspartate-rich region 1; other site 227882000099 aspartate-rich region 2; other site 227882000100 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 227882000101 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 227882000102 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 227882000103 DNA binding residues [nucleotide binding] 227882000104 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 227882000105 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 227882000106 tetracycline repressor protein TetR; Provisional; Region: PRK13756 227882000107 Erythromycin esterase; Region: Erythro_esteras; pfam05139 227882000108 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 227882000109 DNA binding residues [nucleotide binding] 227882000110 putative dimer interface [polypeptide binding]; other site 227882000111 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 227882000112 DNA binding residues [nucleotide binding] 227882000113 putative dimer interface [polypeptide binding]; other site 227882000114 Predicted transcriptional regulators [Transcription]; Region: COG1378 227882000115 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882000116 DNA binding residues [nucleotide binding] 227882000117 dimerization interface [polypeptide binding]; other site 227882000118 Short repeats of unknown function; Region: ALF; pfam03752 227882000119 Short repeats of unknown function; Region: ALF; pfam03752 227882000120 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882000121 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 227882000122 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan...; Region: Sortase_E; cd05829 227882000123 active site 227882000124 putative catalytic site [active] 227882000125 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 227882000126 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882000127 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882000128 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 227882000129 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 227882000130 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 227882000131 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 227882000132 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 227882000133 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882000134 active site 227882000135 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882000136 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882000137 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 227882000138 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 227882000139 substrate-cofactor binding pocket; other site 227882000140 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882000141 catalytic residue [active] 227882000142 Transposase, Mutator family; Region: Transposase_mut; pfam00872 227882000143 Transposase, Mutator family; Region: Transposase_mut; pfam00872 227882000144 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 227882000145 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 227882000146 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 227882000147 Cytochrome P450; Region: p450; cl12078 227882000148 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882000149 DNA binding residues [nucleotide binding] 227882000150 dimerization interface [polypeptide binding]; other site 227882000151 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 227882000152 PAS fold; Region: PAS_4; pfam08448 227882000153 GAF domain; Region: GAF; cl00853 227882000154 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882000155 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 227882000156 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 227882000157 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 227882000158 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 227882000159 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 227882000160 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882000161 Transposase; Region: DEDD_Tnp_IS110; pfam01548 227882000162 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 227882000163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882000164 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882000165 Peptidase family M48; Region: Peptidase_M48; cl12018 227882000166 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 227882000167 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 227882000168 active site 227882000169 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 227882000170 active site 227882000171 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 227882000172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882000173 active site 227882000174 phosphorylation site [posttranslational modification] 227882000175 intermolecular recognition site; other site 227882000176 dimerization interface [polypeptide binding]; other site 227882000177 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882000178 DNA binding site [nucleotide binding] 227882000179 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 227882000180 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 227882000181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882000182 ATP binding site [chemical binding]; other site 227882000183 Mg2+ binding site [ion binding]; other site 227882000184 G-X-G motif; other site 227882000185 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 227882000186 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 227882000187 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 227882000188 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 227882000189 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 227882000190 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 227882000191 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 227882000192 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 227882000193 Membrane transport protein; Region: Mem_trans; cl09117 227882000194 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882000195 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 227882000196 dimer interface [polypeptide binding]; other site 227882000197 phosphorylation site [posttranslational modification] 227882000198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882000199 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 227882000200 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 227882000201 Walker A/P-loop; other site 227882000202 ATP binding site [chemical binding]; other site 227882000203 Q-loop/lid; other site 227882000204 ABC transporter signature motif; other site 227882000205 Walker B; other site 227882000206 D-loop; other site 227882000207 H-loop/switch region; other site 227882000208 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 227882000209 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882000210 Walker A/P-loop; other site 227882000211 ATP binding site [chemical binding]; other site 227882000212 Q-loop/lid; other site 227882000213 ABC transporter signature motif; other site 227882000214 Walker B; other site 227882000215 D-loop; other site 227882000216 H-loop/switch region; other site 227882000217 LolC/E family; Region: lolCE; TIGR02212 227882000218 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 227882000219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882000220 active site 227882000221 phosphorylation site [posttranslational modification] 227882000222 intermolecular recognition site; other site 227882000223 dimerization interface [polypeptide binding]; other site 227882000224 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882000225 DNA binding site [nucleotide binding] 227882000226 NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231 227882000227 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 227882000228 putative NADP binding site [chemical binding]; other site 227882000229 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882000230 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882000231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882000232 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 227882000233 NAD(P) binding site [chemical binding]; other site 227882000234 active site 227882000235 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882000236 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882000237 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 227882000238 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 227882000239 ABC-2 type transporter; Region: ABC2_membrane; cl11417 227882000240 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 227882000241 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 227882000242 Major royal jelly protein; Region: MRJP; pfam03022 227882000243 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 227882000244 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 227882000245 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 227882000246 NADP binding site [chemical binding]; other site 227882000247 active site 227882000248 steroid binding site; other site 227882000249 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882000250 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882000251 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882000252 NAD(P) binding site [chemical binding]; other site 227882000253 active site 227882000254 short chain dehydrogenase; Validated; Region: PRK05855 227882000255 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882000256 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 227882000257 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 227882000258 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 227882000259 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-...; Region: PDR_like; cd06185 227882000260 FMN-binding pocket [chemical binding]; other site 227882000261 flavin binding motif; other site 227882000262 phosphate binding motif [ion binding]; other site 227882000263 beta-alpha-beta structure motif; other site 227882000264 NAD binding pocket [chemical binding]; other site 227882000265 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 227882000266 catalytic loop [active] 227882000267 iron binding site [ion binding]; other site 227882000268 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 227882000269 Phage integrase family; Region: Phage_integrase; pfam00589 227882000270 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 227882000271 Int/Topo IB signature motif; other site 227882000272 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 227882000273 Phage integrase family; Region: Phage_integrase; pfam00589 227882000274 DNA binding site [nucleotide binding] 227882000275 Int/Topo IB signature motif; other site 227882000276 active site 227882000277 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 227882000278 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 227882000279 AAA-like domain; Region: AAA_10; pfam12846 227882000280 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 227882000281 NlpC/P60 family; Region: NLPC_P60; cl11438 227882000282 SAF domain; Region: SAF; cl00555 227882000283 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 227882000284 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 227882000285 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882000286 Walker A motif; other site 227882000287 ATP binding site [chemical binding]; other site 227882000288 Walker B motif; other site 227882000289 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 227882000290 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 227882000291 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 227882000292 TadE-like protein; Region: TadE; pfam07811 227882000293 TadE-like protein; Region: TadE; pfam07811 227882000294 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 227882000295 Bacterial transcriptional activator domain; Region: BTAD; smart01043 227882000296 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 227882000297 transcriptional regulator ICP4; Provisional; Region: PHA03307 227882000298 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882000299 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 227882000300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882000301 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882000302 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 227882000303 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 227882000304 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 227882000305 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 227882000306 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 227882000307 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 227882000308 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 227882000309 protein-splicing catalytic site; other site 227882000310 thioester formation/cholesterol transfer; other site 227882000311 Protein of unknown function (DUF1557); Region: DUF1557; pfam07591 227882000312 Pyocin large subunit [General function prediction only]; Region: COG5529 227882000313 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 227882000314 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882000315 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882000316 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 227882000317 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 227882000318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882000319 Walker A motif; other site 227882000320 ATP binding site [chemical binding]; other site 227882000321 Walker B motif; other site 227882000322 Transposase; Region: DEDD_Tnp_IS110; pfam01548 227882000323 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 227882000324 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 227882000325 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882000326 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882000327 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 227882000328 Walker A motif; other site 227882000329 ATP binding site [chemical binding]; other site 227882000330 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 227882000331 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 227882000332 non-specific DNA binding site [nucleotide binding]; other site 227882000333 salt bridge; other site 227882000334 sequence-specific DNA binding site [nucleotide binding]; other site 227882000335 Domain of unknown function (DUF955); Region: DUF955; cl01076 227882000336 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cl00358 227882000337 Helicase associated domain; Region: HA; pfam03457 227882000338 Helicase associated domain; Region: HA; pfam03457 227882000339 Transposase, Mutator family; Region: Transposase_mut; pfam00872 227882000340 MULE transposase domain; Region: MULE; pfam10551 227882000341 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 227882000342 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 227882000343 putative active site [active] 227882000344 putative NTP binding site [chemical binding]; other site 227882000345 putative nucleic acid binding site [nucleotide binding]; other site 227882000346 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 227882000347 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 227882000348 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 227882000349 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 227882000350 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 227882000351 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 227882000352 DNA binding residues [nucleotide binding] 227882000353 dimer interface [polypeptide binding]; other site 227882000354 metal binding site [ion binding]; metal-binding site 227882000355 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 227882000356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882000357 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 227882000358 anti sigma factor interaction site; other site 227882000359 regulatory phosphorylation site [posttranslational modification]; other site 227882000360 GAF domain; Region: GAF; cl00853 227882000361 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 227882000362 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882000363 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 227882000364 LysE type translocator; Region: LysE; cl00565 227882000365 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882000366 catalytic residue [active] 227882000367 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882000368 Archaeal ATPase; Region: Arch_ATPase; pfam01637 227882000369 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 227882000370 binding surface 227882000371 TPR motif; other site 227882000372 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 227882000373 binding surface 227882000374 TPR motif; other site 227882000375 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 227882000376 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882000377 Q-loop/lid; other site 227882000378 ABC transporter signature motif; other site 227882000379 Walker B; other site 227882000380 D-loop; other site 227882000381 H-loop/switch region; other site 227882000382 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 227882000383 nudix motif; other site 227882000384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 227882000385 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 227882000386 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 227882000387 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 227882000388 Zn binding site [ion binding]; other site 227882000389 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 227882000390 Transposase [DNA replication, recombination, and repair]; Region: COG5433 227882000391 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882000392 Walker A/P-loop; other site 227882000393 ATP binding site [chemical binding]; other site 227882000394 Q-loop/lid; other site 227882000395 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 227882000396 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 227882000397 Ligand Binding Site [chemical binding]; other site 227882000398 Molecular Tunnel; other site 227882000399 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 227882000400 Transposase; Region: DDE_Tnp_ISL3; pfam01610 227882000401 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 227882000402 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 227882000403 Putative amidase domain; Region: Amidase_6; pfam12671 227882000404 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 227882000405 DNA-binding interface [nucleotide binding]; DNA binding site 227882000406 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 227882000407 nudix motif; other site 227882000408 Recombination endonuclease VII; Region: Endonuclease_7; pfam02945 227882000409 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 227882000410 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 227882000411 DNA binding site [nucleotide binding] 227882000412 active site 227882000413 Int/Topo IB signature motif; other site 227882000414 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 227882000415 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 227882000416 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 227882000417 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 227882000418 protein-splicing catalytic site; other site 227882000419 thioester formation/cholesterol transfer; other site 227882000420 Protein of unknown function (DUF1557); Region: DUF1557; pfam07591 227882000421 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 227882000422 Integrase core domain; Region: rve; cl01316 227882000423 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 227882000424 Integrase core domain; Region: rve; cl01316 227882000425 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882000426 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 227882000427 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 227882000428 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 227882000429 FAD binding pocket [chemical binding]; other site 227882000430 FAD binding motif [chemical binding]; other site 227882000431 phosphate binding motif [ion binding]; other site 227882000432 beta-alpha-beta structure motif; other site 227882000433 NAD binding pocket [chemical binding]; other site 227882000434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882000435 hypothetical protein; Provisional; Region: PRK06184 227882000436 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882000437 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882000438 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882000439 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 227882000440 Transposase, Mutator family; Region: Transposase_mut; pfam00872 227882000441 MULE transposase domain; Region: MULE; pfam10551 227882000442 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 227882000443 Transposase; Region: DEDD_Tnp_IS110; pfam01548 227882000444 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 227882000445 putative MFS family transporter protein; Provisional; Region: PRK03633 227882000446 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 227882000447 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 227882000448 Protein of unknown function (DUF419); Region: DUF419; cl15265 227882000449 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 227882000450 active site 227882000451 metal binding site [ion binding]; metal-binding site 227882000452 Rhodopirellula transposase; Region: DDE_Tnp_ISAZ013; pfam07592 227882000453 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 227882000454 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 227882000455 Integrase core domain; Region: rve; cl01316 227882000456 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 227882000457 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 227882000458 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 227882000459 putative transposase OrfB; Reviewed; Region: PHA02517 227882000460 Integrase core domain; Region: rve; cl01316 227882000461 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 227882000462 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 227882000463 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 227882000464 DNA binding residues [nucleotide binding] 227882000465 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 227882000466 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882000467 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882000468 Haemolysin-III related; Region: HlyIII; cl03831 227882000469 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 227882000470 DNA binding residues [nucleotide binding] 227882000471 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 227882000472 putative DNA binding site [nucleotide binding]; other site 227882000473 putative Zn2+ binding site [ion binding]; other site 227882000474 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 227882000475 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 227882000476 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 227882000477 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918 227882000478 active site 227882000479 L-lactate dehydrogenase-like enzymes; Region: LDH_like; cd00300 227882000480 NAD(P) binding site [chemical binding]; other site 227882000481 dimer interface [polypeptide binding]; other site 227882000482 tetramer (dimer of dimers) interface [polypeptide binding]; other site 227882000483 substrate binding site [chemical binding]; other site 227882000484 Competence protein CoiA-like family; Region: CoiA; cl11541 227882000485 Transposase, Mutator family; Region: Transposase_mut; pfam00872 227882000486 MULE transposase domain; Region: MULE; pfam10551 227882000487 hydroperoxidase II; Provisional; Region: katE; PRK11249 227882000488 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 227882000489 heme binding pocket [chemical binding]; other site 227882000490 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 227882000491 domain interactions; other site 227882000492 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 227882000493 GAF domain; Region: GAF; cl00853 227882000494 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882000495 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882000496 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 227882000497 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 227882000498 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 227882000499 NAD binding site [chemical binding]; other site 227882000500 substrate binding site [chemical binding]; other site 227882000501 active site 227882000502 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 227882000503 active site 227882000504 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 227882000505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882000506 NAD(P) binding site [chemical binding]; other site 227882000507 active site 227882000508 Spherulation-specific family 4; Region: Spherulin4; pfam12138 227882000509 Cytochrome P450; Region: p450; cl12078 227882000510 putative transposase OrfB; Reviewed; Region: PHA02517 227882000511 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882000512 Transposase; Region: DEDD_Tnp_IS110; pfam01548 227882000513 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 227882000514 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 227882000515 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 227882000516 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 227882000517 SNF2 Helicase protein; Region: DUF3670; pfam12419 227882000518 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 227882000519 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 227882000520 ATP binding site [chemical binding]; other site 227882000521 putative Mg++ binding site [ion binding]; other site 227882000522 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 227882000523 nucleotide binding region [chemical binding]; other site 227882000524 ATP-binding site [chemical binding]; other site 227882000525 Uncharacterized conserved protein [Function unknown]; Region: COG4279 227882000526 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 227882000527 Int/Topo IB signature motif; other site 227882000528 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 227882000529 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 227882000530 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 227882000531 active site 227882000532 Transcriptional regulator [Transcription]; Region: LysR; COG0583 227882000533 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882000534 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 227882000535 putative substrate binding pocket [chemical binding]; other site 227882000536 putative dimerization interface [polypeptide binding]; other site 227882000537 Transposase IS200 like; Region: Y1_Tnp; cl00848 227882000538 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 227882000539 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 227882000540 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882000541 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 227882000542 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 227882000543 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882000544 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 227882000545 Walker A motif; other site 227882000546 ATP binding site [chemical binding]; other site 227882000547 Walker B motif; other site 227882000548 arginine finger; other site 227882000549 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 227882000550 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 227882000551 Phage-related baseplate assembly protein; Region: Phage_base_V; cl11432 227882000552 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 227882000553 Baseplate J-like protein; Region: Baseplate_J; cl01294 227882000554 Baseplate J-like protein; Region: Baseplate_J; cl01294 227882000555 Baseplate J-like protein; Region: Baseplate_J; cl01294 227882000556 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 227882000557 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882000558 Walker A motif; other site 227882000559 ATP binding site [chemical binding]; other site 227882000560 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882000561 DNA binding residues [nucleotide binding] 227882000562 dimerization interface [polypeptide binding]; other site 227882000563 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 227882000564 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 227882000565 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 227882000566 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 227882000567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882000568 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 227882000569 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882000570 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 227882000571 nudix motif; other site 227882000572 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 227882000573 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 227882000574 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 227882000575 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 227882000576 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 227882000577 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882000578 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 227882000579 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 227882000580 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 227882000581 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 227882000582 Cytochrome P450; Region: p450; cl12078 227882000583 Cytochrome P450; Region: p450; cl12078 227882000584 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 227882000585 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 227882000586 NAD(P) binding site [chemical binding]; other site 227882000587 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882000588 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882000589 active site 227882000590 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882000591 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882000592 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 227882000593 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 227882000594 active site 227882000595 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882000596 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882000597 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882000598 active site 227882000599 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882000600 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882000601 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 227882000602 NADP binding site [chemical binding]; other site 227882000603 active site 227882000604 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882000605 Thioesterase; Region: PKS_TE; smart00824 227882000606 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882000607 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882000608 active site 227882000609 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882000610 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882000611 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 227882000612 NADP binding site [chemical binding]; other site 227882000613 active site 227882000614 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882000615 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882000616 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882000617 active site 227882000618 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882000619 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882000620 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 227882000621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882000622 active site 227882000623 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882000624 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882000625 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882000626 active site 227882000627 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882000628 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882000629 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 227882000630 NADP binding site [chemical binding]; other site 227882000631 active site 227882000632 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882000633 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882000634 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882000635 active site 227882000636 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882000637 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882000638 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 227882000639 NADP binding site [chemical binding]; other site 227882000640 active site 227882000641 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882000642 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 227882000643 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882000644 active site 227882000645 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882000646 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882000647 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882000648 putative NADP binding site [chemical binding]; other site 227882000649 active site 227882000650 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882000651 acyl-CoA synthetase; Validated; Region: PRK06060 227882000652 Erythronolide synthase docking; Region: Docking; pfam08990 227882000653 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 227882000654 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882000655 active site 227882000656 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882000657 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882000658 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882000659 putative NADP binding site [chemical binding]; other site 227882000660 active site 227882000661 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882000662 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 227882000663 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882000664 active site 227882000665 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882000666 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882000667 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882000668 putative NADP binding site [chemical binding]; other site 227882000669 active site 227882000670 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882000671 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 227882000672 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882000673 active site 227882000674 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882000675 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882000676 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882000677 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882000678 active site 227882000679 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882000680 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882000681 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 227882000682 NADP binding site [chemical binding]; other site 227882000683 active site 227882000684 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882000685 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 227882000686 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882000687 active site 227882000688 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882000689 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882000690 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882000691 putative NADP binding site [chemical binding]; other site 227882000692 active site 227882000693 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882000694 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 227882000695 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882000696 active site 227882000697 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882000698 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882000699 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882000700 putative NADP binding site [chemical binding]; other site 227882000701 active site 227882000702 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882000703 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882000704 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882000705 active site 227882000706 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882000707 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882000708 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882000709 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882000710 putative NADP binding site [chemical binding]; other site 227882000711 active site 227882000712 acyl-CoA synthetase; Validated; Region: PRK06060 227882000713 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882000714 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 227882000715 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 227882000716 Integrase core domain; Region: rve; cl01316 227882000717 putative transposase OrfB; Reviewed; Region: PHA02517 227882000718 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 227882000719 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882000720 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882000721 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 227882000722 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 227882000723 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 227882000724 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 227882000725 putative hydrophobic ligand binding site [chemical binding]; other site 227882000726 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 227882000727 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 227882000728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882000729 NAD(P) binding site [chemical binding]; other site 227882000730 active site 227882000731 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882000732 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882000733 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 227882000734 Carboxylesterase family; Region: COesterase; pfam00135 227882000735 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882000736 substrate binding pocket [chemical binding]; other site 227882000737 catalytic triad [active] 227882000738 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882000739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882000740 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 227882000741 putative active site [active] 227882000742 heme pocket [chemical binding]; other site 227882000743 PAS fold; Region: PAS_4; pfam08448 227882000744 GAF domain; Region: GAF; cl00853 227882000745 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882000746 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882000747 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882000748 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 227882000749 Protein of unknown function (DUF2855); Region: DUF2855; pfam11017 227882000750 NAD(P) binding site [chemical binding]; other site 227882000751 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 227882000752 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 227882000753 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 227882000754 alphaNTD homodimer interface [polypeptide binding]; other site 227882000755 alphaNTD - beta interaction site [polypeptide binding]; other site 227882000756 alphaNTD - beta' interaction site [polypeptide binding]; other site 227882000757 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 227882000758 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 227882000759 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 227882000760 RHS Repeat; Region: RHS_repeat; cl11982 227882000761 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 227882000762 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 227882000763 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 227882000764 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 227882000765 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882000766 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882000767 Stress responsive A/B Barrel Domain; Region: Dabb; cl06768 227882000768 atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229 227882000769 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 227882000770 putative NAD(P) binding site [chemical binding]; other site 227882000771 putative active site [active] 227882000772 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 227882000773 anti sigma factor interaction site; other site 227882000774 regulatory phosphorylation site [posttranslational modification]; other site 227882000775 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 227882000776 Uncharacterized conserved protein [Function unknown]; Region: COG4715 227882000777 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 227882000778 putative dimer interface [polypeptide binding]; other site 227882000779 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 227882000780 Cupin domain; Region: Cupin_2; cl09118 227882000781 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 227882000782 isoform II; Region: PAF-AH_p_II; pfam03403 227882000783 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 227882000784 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 227882000785 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 227882000786 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 227882000787 Leucine carboxyl methyltransferase; Region: LCM; cl01306 227882000788 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 227882000789 putative dimer interface [polypeptide binding]; other site 227882000790 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882000791 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 227882000792 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882000793 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882000794 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 227882000795 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882000796 enoyl-CoA hydratase; Provisional; Region: PRK06688 227882000797 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 227882000798 substrate binding site [chemical binding]; other site 227882000799 oxyanion hole (OAH) forming residues; other site 227882000800 trimer interface [polypeptide binding]; other site 227882000801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882000802 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 227882000803 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 227882000804 DNA binding site [nucleotide binding] 227882000805 active site 227882000806 Int/Topo IB signature motif; other site 227882000807 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 227882000808 Domain of unknown function (DUF1994); Region: DUF1994; pfam09352 227882000809 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 227882000810 rRNA binding site [nucleotide binding]; other site 227882000811 predicted 30S ribosome binding site; other site 227882000812 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 227882000813 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 227882000814 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882000815 putative substrate translocation pore; other site 227882000816 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 227882000817 aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227 227882000818 NADP binding site [chemical binding]; other site 227882000819 putative substrate binding site [chemical binding]; other site 227882000820 active site 227882000821 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882000822 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882000823 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 227882000824 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 227882000825 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 227882000826 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882000827 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 227882000828 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 227882000829 conserved cys residue [active] 227882000830 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882000831 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882000832 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 227882000833 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 227882000834 catalytic loop [active] 227882000835 iron binding site [ion binding]; other site 227882000836 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 227882000837 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 227882000838 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 227882000839 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 227882000840 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882000841 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882000842 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882000843 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 227882000844 CDP-diacylglycerol pyrophosphatase; Region: CDH; cl00934 227882000845 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 227882000846 putative RNA polymerase sigma E protein; Provisional; Region: PRK13919 227882000847 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882000848 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 227882000849 ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the...; Region: ABC_drug_resistance_like; cd03264 227882000850 Walker A/P-loop; other site 227882000851 ATP binding site [chemical binding]; other site 227882000852 Q-loop/lid; other site 227882000853 ABC transporter signature motif; other site 227882000854 Walker B; other site 227882000855 D-loop; other site 227882000856 H-loop/switch region; other site 227882000857 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882000858 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 227882000859 NAD-dependent deacetylase; Provisional; Region: PRK05333 227882000860 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/...; Region: SIRT4; cd01409 227882000861 NAD+ binding site [chemical binding]; other site 227882000862 substrate binding site [chemical binding]; other site 227882000863 Zn binding site [ion binding]; other site 227882000864 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 227882000865 DNA binding residues [nucleotide binding] 227882000866 putative dimer interface [polypeptide binding]; other site 227882000867 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882000868 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192 227882000869 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 227882000870 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 227882000871 homodimer interface [polypeptide binding]; other site 227882000872 NADP binding site [chemical binding]; other site 227882000873 substrate binding site [chemical binding]; other site 227882000874 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 227882000875 calcium binding site 2 [ion binding]; other site 227882000876 active site 227882000877 catalytic triad [active] 227882000878 calcium binding site 1 [ion binding]; other site 227882000879 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 227882000880 dimerization interface [polypeptide binding]; other site 227882000881 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 227882000882 active site 227882000883 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 227882000884 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 227882000885 putative NAD(P) binding site [chemical binding]; other site 227882000886 catalytic Zn binding site [ion binding]; other site 227882000887 structural Zn binding site [ion binding]; other site 227882000888 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 227882000889 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 227882000890 binding surface 227882000891 TPR motif; other site 227882000892 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 227882000893 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882000894 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 227882000895 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882000896 putative substrate translocation pore; other site 227882000897 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882000898 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882000899 DNA binding site [nucleotide binding] 227882000900 domain linker motif; other site 227882000901 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 227882000902 putative dimerization interface [polypeptide binding]; other site 227882000903 putative ligand binding site [chemical binding]; other site 227882000904 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 227882000905 Cellulose binding domain; Region: CBM_2; cl02709 227882000906 Cellulose binding domain; Region: CBM_2; cl02709 227882000907 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 227882000908 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 227882000909 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 227882000910 Interdomain contacts; other site 227882000911 Cytokine receptor motif; other site 227882000912 Cellulose binding domain; Region: CBM_3; cl03026 227882000913 High-affinity nickel-transport protein; Region: NicO; cl00964 227882000914 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 227882000915 putative FMN binding site [chemical binding]; other site 227882000916 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 227882000917 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 227882000918 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882000919 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 227882000920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882000921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882000922 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 227882000923 N-terminal domain of 2,4,5-trihydroxytoluene (THT) oxygenase; Region: THT_Oxygenase_N; cd07267 227882000924 The C-terminal domain of 2,4,5-Trihydroxytoluene (THT) oxygenase, which is an extradiol dioxygenease in the 2,4-dinitrotoluene (DNT) degradation pathway; Region: THT_oxygenase_C; cd07257 227882000925 putative active site [active] 227882000926 putative metal binding site [ion binding]; other site 227882000927 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882000928 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882000929 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 227882000930 phosphate binding site [ion binding]; other site 227882000931 GAF domain; Region: GAF; cl00853 227882000932 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882000933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882000934 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882000935 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 227882000936 Uncharacterised protein family (UPF0167); Region: UPF0167; cl01252 227882000937 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 227882000938 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 227882000939 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 227882000940 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 227882000941 putative NAD(P) binding site [chemical binding]; other site 227882000942 catalytic Zn binding site [ion binding]; other site 227882000943 structural Zn binding site [ion binding]; other site 227882000944 cytochrome P450 83B1; Provisional; Region: PLN03234 227882000945 Cytochrome P450; Region: p450; cl12078 227882000946 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 227882000947 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 227882000948 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 227882000949 FAD binding pocket [chemical binding]; other site 227882000950 FAD binding motif [chemical binding]; other site 227882000951 catalytic residues [active] 227882000952 NAD binding pocket [chemical binding]; other site 227882000953 phosphate binding motif [ion binding]; other site 227882000954 beta-alpha-beta structure motif; other site 227882000955 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882000956 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 227882000957 tetracycline repressor protein TetR; Provisional; Region: PRK13756 227882000958 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882000959 NIPSNAP; Region: NIPSNAP; pfam07978 227882000960 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 227882000961 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 227882000962 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 227882000963 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882000964 Cytochrome P450; Region: p450; cl12078 227882000965 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 227882000966 PAS fold; Region: PAS; pfam00989 227882000967 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 227882000968 putative active site [active] 227882000969 heme pocket [chemical binding]; other site 227882000970 PAS fold; Region: PAS_4; pfam08448 227882000971 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 227882000972 GAF domain; Region: GAF; cl00853 227882000973 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882000974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882000975 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 227882000976 putative active site [active] 227882000977 heme pocket [chemical binding]; other site 227882000978 GAF domain; Region: GAF; cl00853 227882000979 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882000980 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882000981 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 227882000982 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882000983 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 227882000984 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882000985 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 227882000986 nucleoside/Zn binding site; other site 227882000987 dimer interface [polypeptide binding]; other site 227882000988 catalytic motif [active] 227882000989 Gas vesicle protein K; Region: GvpK; pfam05121 227882000990 Gas vesicle protein; Region: Gas_vesicle; cl02954 227882000991 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 227882000992 Gas vesicle protein; Region: Gas_vesicle; cl02954 227882000993 Gas vesicle protein G; Region: GvpG; pfam05120 227882000994 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 227882000995 Gas vesicle protein; Region: Gas_vesicle; cl02954 227882000996 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 227882000997 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 227882000998 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 227882000999 Walker A/P-loop; other site 227882001000 ATP binding site [chemical binding]; other site 227882001001 Q-loop/lid; other site 227882001002 ABC transporter signature motif; other site 227882001003 Walker B; other site 227882001004 D-loop; other site 227882001005 H-loop/switch region; other site 227882001006 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 227882001007 dimer interface [polypeptide binding]; other site 227882001008 putative PBP binding regions; other site 227882001009 ABC-ATPase subunit interface; other site 227882001010 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 227882001011 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 227882001012 putative ligand binding residues [chemical binding]; other site 227882001013 Condensation domain; Region: Condensation; cl09290 227882001014 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 227882001015 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882001016 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001017 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 227882001018 thioester reductase domain; Region: Thioester-redct; TIGR01746 227882001019 putative NAD(P) binding site [chemical binding]; other site 227882001020 active site 227882001021 putative substrate binding site [chemical binding]; other site 227882001022 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001023 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 227882001024 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882001025 FcoT-like thioesterase domain; Region: FcoT; pfam10862 227882001026 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 227882001027 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 227882001028 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001029 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 227882001030 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 227882001031 dimer interface [polypeptide binding]; other site 227882001032 active site 227882001033 CoA binding pocket [chemical binding]; other site 227882001034 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882001035 putative substrate translocation pore; other site 227882001036 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl01426 227882001037 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 227882001038 Protein of unknown function (DUF461); Region: DUF461; cl01071 227882001039 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882001040 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882001041 Protein of unknown function (DUF461); Region: DUF461; cl01071 227882001042 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 227882001043 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 227882001044 metal-binding site [ion binding] 227882001045 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 227882001046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882001047 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882001048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882001049 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882001050 DNA binding residues [nucleotide binding] 227882001051 dimerization interface [polypeptide binding]; other site 227882001052 Transcriptional regulator [Transcription]; Region: LysR; COG0583 227882001053 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882001054 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 227882001055 dimerization interface [polypeptide binding]; other site 227882001056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882001057 S-adenosylmethionine binding site [chemical binding]; other site 227882001058 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 227882001059 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 227882001060 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 227882001061 putative sugar binding sites [chemical binding]; other site 227882001062 Q-X-W motif; other site 227882001063 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882001064 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882001065 DNA binding site [nucleotide binding] 227882001066 domain linker motif; other site 227882001067 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 227882001068 dimerization interface [polypeptide binding]; other site 227882001069 ligand binding site [chemical binding]; other site 227882001070 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 227882001071 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 227882001072 Transposase; Region: DEDD_Tnp_IS110; pfam01548 227882001073 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 227882001074 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 227882001075 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 227882001076 substrate binding site [chemical binding]; other site 227882001077 oxyanion hole (OAH) forming residues; other site 227882001078 trimer interface [polypeptide binding]; other site 227882001079 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 227882001080 conserved cys residue [active] 227882001081 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 227882001082 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882001083 substrate binding site [chemical binding]; other site 227882001084 activation loop (A-loop); other site 227882001085 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882001086 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 227882001087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882001088 ATP binding site [chemical binding]; other site 227882001089 G-X-G motif; other site 227882001090 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882001091 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 227882001092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882001093 active site 227882001094 phosphorylation site [posttranslational modification] 227882001095 intermolecular recognition site; other site 227882001096 dimerization interface [polypeptide binding]; other site 227882001097 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882001098 DNA binding site [nucleotide binding] 227882001099 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 227882001100 ATP-binding site [chemical binding]; other site 227882001101 Gluconate-6-phosphate binding site [chemical binding]; other site 227882001102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882001103 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 227882001104 Cupin domain; Region: Cupin_2; cl09118 227882001105 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882001106 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 227882001107 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 227882001108 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 227882001109 active site 227882001110 catalytic tetrad [active] 227882001111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882001112 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 227882001113 conserved cys residue [active] 227882001114 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 227882001115 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 227882001116 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 227882001117 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882001118 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882001119 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 227882001120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882001121 S-adenosylmethionine binding site [chemical binding]; other site 227882001122 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001123 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 227882001124 NAD(P) binding site [chemical binding]; other site 227882001125 active site 227882001126 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 227882001127 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001129 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 227882001130 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 227882001131 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882001132 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 227882001133 PemK-like protein; Region: PemK; cl00995 227882001134 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 227882001135 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 227882001136 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882001137 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 227882001138 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 227882001139 putative NAD(P) binding site [chemical binding]; other site 227882001140 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 227882001141 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882001142 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 227882001143 substrate binding site [chemical binding]; other site 227882001144 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 227882001145 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 227882001146 putative dimer interface [polypeptide binding]; other site 227882001147 ABC-2 type transporter; Region: ABC2_membrane; cl11417 227882001148 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882001149 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 227882001150 Walker A/P-loop; other site 227882001151 ATP binding site [chemical binding]; other site 227882001152 Q-loop/lid; other site 227882001153 ABC transporter signature motif; other site 227882001154 Walker B; other site 227882001155 D-loop; other site 227882001156 H-loop/switch region; other site 227882001157 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 227882001158 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882001159 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 227882001160 PAS fold; Region: PAS_4; pfam08448 227882001161 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882001162 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882001163 short chain dehydrogenase; Provisional; Region: PRK05872 227882001164 classical (c) SDRs; Region: SDR_c; cd05233 227882001165 NAD(P) binding site [chemical binding]; other site 227882001166 active site 227882001167 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 227882001168 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882001169 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882001170 DNA binding residues [nucleotide binding] 227882001171 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 227882001172 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 227882001173 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 227882001174 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 227882001175 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 227882001176 Coenzyme A binding pocket [chemical binding]; other site 227882001177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882001178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882001179 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 227882001180 2-enoyl thioester reductase (ETR) like proteins, child 2; Region: ETR_like_2; cd08292 227882001181 putative NAD(P) binding site [chemical binding]; other site 227882001182 putative dimer interface [polypeptide binding]; other site 227882001183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001184 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 227882001185 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 227882001186 NADP binding site [chemical binding]; other site 227882001187 dimer interface [polypeptide binding]; other site 227882001188 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 227882001189 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882001190 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 227882001191 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 227882001192 motif I; other site 227882001193 active site 227882001194 Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; cl10508 227882001195 Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; cl10508 227882001196 Low-density lipoprotein receptor repeat class B; Region: Ldl_recept_b; cl10508 227882001197 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07066 227882001198 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 227882001199 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 227882001200 enoyl-CoA hydratase; Provisional; Region: PRK08252 227882001201 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 227882001202 substrate binding site [chemical binding]; other site 227882001203 oxyanion hole (OAH) forming residues; other site 227882001204 trimer interface [polypeptide binding]; other site 227882001205 CoA-transferase family III; Region: CoA_transf_3; cl00778 227882001206 acyl-coenzyme A oxidase; Region: PLN02526 227882001207 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882001208 active site 227882001209 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 227882001210 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 227882001211 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882001212 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 227882001213 short chain dehydrogenase; Provisional; Region: PRK06197 227882001214 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 227882001215 putative NAD(P) binding site [chemical binding]; other site 227882001216 active site 227882001217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001218 NAD(P) binding site [chemical binding]; other site 227882001219 active site 227882001220 Transcriptional regulator [Transcription]; Region: LysR; COG0583 227882001221 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882001222 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 227882001223 putative dimerization interface [polypeptide binding]; other site 227882001224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001225 NAD(P) binding site [chemical binding]; other site 227882001226 active site 227882001227 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 227882001228 active site 227882001229 metal binding site [ion binding]; metal-binding site 227882001230 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 227882001231 active site 227882001232 metal binding site [ion binding]; metal-binding site 227882001233 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 227882001234 active site triad [active] 227882001235 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882001236 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 227882001237 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882001238 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 227882001239 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 227882001240 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882001241 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882001242 DNA binding residues [nucleotide binding] 227882001243 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 227882001244 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882001245 Peptidase inhibitor family I36; Region: Inhibitor_I36; pfam03995 227882001246 Integrase core domain; Region: rve; cl01316 227882001247 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 227882001248 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 227882001249 active site 227882001250 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 227882001251 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 227882001252 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 227882001253 putative dimer interface [polypeptide binding]; other site 227882001254 classical (c) SDRs; Region: SDR_c; cd05233 227882001255 NAD(P) binding site [chemical binding]; other site 227882001256 active site 227882001257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 227882001258 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 227882001259 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882001260 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 227882001261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882001262 S-adenosylmethionine binding site [chemical binding]; other site 227882001263 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 227882001264 PAS fold; Region: PAS; pfam00989 227882001265 PAS fold; Region: PAS_4; pfam08448 227882001266 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 227882001267 putative active site [active] 227882001268 heme pocket [chemical binding]; other site 227882001269 GAF domain; Region: GAF; cl00853 227882001270 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882001271 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882001272 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 227882001273 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 227882001274 active site 227882001275 metal binding site [ion binding]; metal-binding site 227882001276 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 227882001277 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 227882001278 NADP binding site [chemical binding]; other site 227882001279 active site 227882001280 steroid binding site; other site 227882001281 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 227882001282 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882001283 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 227882001284 dimerization interface [polypeptide binding]; other site 227882001285 substrate binding pocket [chemical binding]; other site 227882001286 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882001287 DNA-binding site [nucleotide binding]; DNA binding site 227882001288 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 227882001289 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882001290 hypothetical protein; Provisional; Region: PRK06834 227882001291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001292 tetracycline repressor protein TetR; Provisional; Region: PRK13756 227882001293 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882001294 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 227882001295 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 227882001296 active site 227882001297 catalytic triad [active] 227882001298 oxyanion hole [active] 227882001299 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 227882001300 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 227882001301 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 227882001302 active site 227882001303 metal binding site [ion binding]; metal-binding site 227882001304 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 227882001305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 227882001306 GAF domain; Region: GAF; cl00853 227882001307 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882001308 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882001309 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882001310 P-loop motif; other site 227882001311 ATP binding site [chemical binding]; other site 227882001312 Chloramphenicol (Cm) binding site [chemical binding]; other site 227882001313 catalytic residue [active] 227882001314 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 227882001315 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 227882001316 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 227882001317 tetrameric interface [polypeptide binding]; other site 227882001318 NAD binding site [chemical binding]; other site 227882001319 catalytic residues [active] 227882001320 substrate binding site [chemical binding]; other site 227882001321 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 227882001322 Sodium:solute symporter family; Region: SSF; cl00456 227882001323 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 227882001324 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 227882001325 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882001326 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 227882001327 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 227882001328 putative arabinose transporter; Provisional; Region: PRK03545 227882001329 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 227882001330 argininosuccinate synthase; Region: argG; TIGR00032 227882001331 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 227882001332 Ligand Binding Site [chemical binding]; other site 227882001333 Alginate lyase; Region: Alginate_lyase2; pfam08787 227882001334 phosphoglucomutase; Validated; Region: PRK07564 227882001335 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 227882001336 active site 227882001337 substrate binding site [chemical binding]; other site 227882001338 metal binding site [ion binding]; metal-binding site 227882001339 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 227882001340 PAS fold; Region: PAS_4; pfam08448 227882001341 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882001342 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882001343 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 227882001344 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 227882001345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001346 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 227882001347 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 227882001348 CsbD-like; Region: CsbD; cl01272 227882001349 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882001350 active site 227882001351 ATP binding site [chemical binding]; other site 227882001352 substrate binding site [chemical binding]; other site 227882001353 activation loop (A-loop); other site 227882001354 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 227882001355 Transposase IS200 like; Region: Y1_Tnp; cl00848 227882001356 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 227882001357 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 227882001358 Probable transposase; Region: OrfB_IS605; pfam01385 227882001359 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 227882001360 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such...; Region: APH_ChoK_like_1; cd05155 227882001361 putative active site [active] 227882001362 putative substrate binding site [chemical binding]; other site 227882001363 ATP binding site [chemical binding]; other site 227882001364 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 227882001365 DNA-binding site [nucleotide binding]; DNA binding site 227882001366 RNA-binding motif; other site 227882001367 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by...; Region: init_cond_enzymes; cd00827 227882001368 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 227882001369 dimer interface [polypeptide binding]; other site 227882001370 active site 227882001371 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 227882001372 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 227882001373 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 227882001374 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882001375 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882001376 DNA binding site [nucleotide binding] 227882001377 domain linker motif; other site 227882001378 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 227882001379 putative dimerization interface [polypeptide binding]; other site 227882001380 putative ligand binding site [chemical binding]; other site 227882001381 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 227882001382 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001383 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 227882001384 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 227882001385 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 227882001386 motif II; other site 227882001387 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 227882001388 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 227882001389 inhibitor-cofactor binding pocket; inhibition site 227882001390 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882001391 catalytic residue [active] 227882001392 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 227882001393 active site 227882001394 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 227882001395 MatE; Region: MatE; cl10513 227882001396 MatE; Region: MatE; cl10513 227882001397 Flavin Reductases; Region: FlaRed; cl00801 227882001398 Cytochrome P450; Region: p450; cl12078 227882001399 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 227882001400 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882001401 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882001402 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 227882001403 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 227882001404 phosphate binding site [ion binding]; other site 227882001405 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 227882001406 homodimer interface [polypeptide binding]; other site 227882001407 substrate-cofactor binding pocket; other site 227882001408 Aminotransferase class IV; Region: Aminotran_4; pfam01063 227882001409 catalytic residue [active] 227882001410 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 227882001411 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cd00741 227882001412 nucleophilic elbow; other site 227882001413 catalytic triad; other site 227882001414 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882001415 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 227882001416 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882001417 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882001418 active site 227882001419 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882001420 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882001421 peptide synthase; Provisional; Region: PRK12316 227882001422 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001423 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 227882001424 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882001425 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882001426 peptide synthase; Validated; Region: PRK05691 227882001427 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882001428 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001429 Condensation domain; Region: Condensation; cl09290 227882001430 peptide synthase; Provisional; Region: PRK12467 227882001431 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882001432 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001433 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 227882001434 B12 binding site [chemical binding]; other site 227882001435 Radical SAM; Region: Elp3; smart00729 227882001436 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 227882001437 DinB superfamily; Region: DinB_2; cl00986 227882001438 MbtH-like protein; Region: MbtH; cl01279 227882001439 Condensation domain; Region: Condensation; cl09290 227882001440 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 227882001441 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001442 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 227882001443 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882001444 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882001445 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 227882001446 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-...; Region: Ntn_PGA_like; cd03747 227882001447 active site 227882001448 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001449 Condensation domain; Region: Condensation; cl09290 227882001450 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 227882001451 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 227882001452 Condensation domain; Region: Condensation; cl09290 227882001453 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 227882001454 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 227882001455 Condensation domain; Region: Condensation; cl09290 227882001456 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 227882001457 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 227882001458 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882001459 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 227882001460 hypothetical protein; Provisional; Region: PRK07206 227882001461 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 227882001462 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001463 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001464 Condensation domain; Region: Condensation; cl09290 227882001465 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 227882001466 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 227882001467 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001468 Cytochrome P450; Region: p450; cl12078 227882001469 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 227882001470 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882001471 Walker A/P-loop; other site 227882001472 ATP binding site [chemical binding]; other site 227882001473 Q-loop/lid; other site 227882001474 ABC transporter signature motif; other site 227882001475 Walker B; other site 227882001476 D-loop; other site 227882001477 H-loop/switch region; other site 227882001478 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 227882001479 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882001480 Walker A/P-loop; other site 227882001481 ATP binding site [chemical binding]; other site 227882001482 Q-loop/lid; other site 227882001483 ABC transporter signature motif; other site 227882001484 Walker B; other site 227882001485 D-loop; other site 227882001486 H-loop/switch region; other site 227882001487 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001488 Condensation domain; Region: Condensation; cl09290 227882001489 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 227882001490 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 227882001491 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 227882001492 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 227882001493 active site 227882001494 catalytic tetrad [active] 227882001495 MbtH-like protein; Region: MbtH; cl01279 227882001496 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 227882001497 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 227882001498 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 227882001499 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882001500 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 227882001501 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882001502 P-loop motif; other site 227882001503 ATP binding site [chemical binding]; other site 227882001504 Chloramphenicol (Cm) binding site [chemical binding]; other site 227882001505 catalytic residue [active] 227882001506 Cupin domain; Region: Cupin_2; cl09118 227882001507 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 227882001508 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 227882001509 putative DNA binding site [nucleotide binding]; other site 227882001510 putative homodimer interface [polypeptide binding]; other site 227882001511 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882001512 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001513 FAD binding domain; Region: FAD_binding_3; pfam01494 227882001514 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001515 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882001516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882001517 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 227882001518 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 227882001519 NADP binding site [chemical binding]; other site 227882001520 Integrase core domain; Region: rve; cl01316 227882001521 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 227882001522 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 227882001523 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 227882001524 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 227882001525 domain; Region: Glyco_hydro_2; pfam00703 227882001526 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 227882001527 sugar binding site [chemical binding]; other site 227882001528 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 227882001529 sugar binding site [chemical binding]; other site 227882001530 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 227882001531 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 227882001532 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882001533 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 227882001534 Cadmium resistance transporter; Region: Cad; cl04177 227882001535 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 227882001536 DNA-binding site [nucleotide binding]; DNA binding site 227882001537 RNA-binding motif; other site 227882001538 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 227882001539 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 227882001540 putative metal binding site [ion binding]; other site 227882001541 Alpha amylase inhibitor; Region: A_amylase_inhib; cl03178 227882001542 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 227882001543 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882001544 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 227882001545 active site 227882001546 metal binding site [ion binding]; metal-binding site 227882001547 Predicted transcriptional regulator [Transcription]; Region: COG2378 227882001548 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882001549 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 227882001550 active site 227882001551 ATP binding site [chemical binding]; other site 227882001552 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 227882001553 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 227882001554 active site 227882001555 catalytic tetrad [active] 227882001556 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 227882001557 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882001558 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 227882001559 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001560 NAD(P) binding site [chemical binding]; other site 227882001561 active site 227882001562 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 227882001563 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882001564 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882001565 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 227882001566 short chain dehydrogenase; Provisional; Region: PRK12828 227882001567 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001568 NAD(P) binding site [chemical binding]; other site 227882001569 active site 227882001570 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 227882001571 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001572 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882001573 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 227882001574 Ligand Binding Site [chemical binding]; other site 227882001575 diaminopimelate decarboxylase; Region: lysA; TIGR01048 227882001576 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 227882001577 active site 227882001578 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 227882001579 substrate binding site [chemical binding]; other site 227882001580 catalytic residues [active] 227882001581 dimer interface [polypeptide binding]; other site 227882001582 K+-transporting ATPase, c chain; Region: KdpC; cl00944 227882001583 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 227882001584 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 227882001585 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882001586 K+-transporting ATPase, A chain [Inorganic ion transport and metabolism]; Region: KdpA; cl00903 227882001587 Potassium-transporting ATPase A subunit; Region: KdpA; pfam03814 227882001588 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 227882001589 anti sigma factor interaction site; other site 227882001590 regulatory phosphorylation site [posttranslational modification]; other site 227882001591 PAS fold; Region: PAS; pfam00989 227882001592 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 227882001593 putative active site [active] 227882001594 heme pocket [chemical binding]; other site 227882001595 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882001596 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882001597 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 227882001598 PAS fold; Region: PAS; pfam00989 227882001599 PAS fold; Region: PAS_4; pfam08448 227882001600 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882001601 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882001602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882001603 conjugal transfer coupling protein TraG; Provisional; Region: PRK13876 227882001604 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 227882001605 amidase catalytic site [active] 227882001606 Zn binding residues [ion binding]; other site 227882001607 substrate binding site [chemical binding]; other site 227882001608 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882001609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882001610 active site 227882001611 phosphorylation site [posttranslational modification] 227882001612 intermolecular recognition site; other site 227882001613 dimerization interface [polypeptide binding]; other site 227882001614 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882001615 DNA binding residues [nucleotide binding] 227882001616 dimerization interface [polypeptide binding]; other site 227882001617 Histidine kinase; Region: HisKA_3; pfam07730 227882001618 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882001619 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 227882001620 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 227882001621 Walker A/P-loop; other site 227882001622 ATP binding site [chemical binding]; other site 227882001623 Q-loop/lid; other site 227882001624 ABC transporter signature motif; other site 227882001625 Walker B; other site 227882001626 D-loop; other site 227882001627 H-loop/switch region; other site 227882001628 Predicted ATPase [General function prediction only]; Region: COG3899 227882001629 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882001630 dimerization interface [polypeptide binding]; other site 227882001631 DNA binding residues [nucleotide binding] 227882001632 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 227882001633 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001634 NAD(P) binding site [chemical binding]; other site 227882001635 active site 227882001636 tocopherol O-methyltransferase; Region: PLN02244 227882001637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882001638 S-adenosylmethionine binding site [chemical binding]; other site 227882001639 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882001640 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882001641 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001642 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882001643 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882001644 active site 227882001645 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882001646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001647 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001648 NAD(P) binding site [chemical binding]; other site 227882001649 active site 227882001650 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001651 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882001652 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882001653 active site 227882001654 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882001655 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882001656 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882001657 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882001658 putative NADP binding site [chemical binding]; other site 227882001659 active site 227882001660 acyl-CoA synthetase; Validated; Region: PRK06060 227882001661 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001662 Erythronolide synthase docking; Region: Docking; pfam08990 227882001663 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882001664 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882001665 active site 227882001666 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882001667 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882001668 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001669 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882001670 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882001671 active site 227882001672 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882001673 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882001674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001675 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 227882001676 NADP binding site [chemical binding]; other site 227882001677 active site 227882001678 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001679 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882001680 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882001681 active site 227882001682 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882001683 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882001684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001685 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 227882001686 NADP binding site [chemical binding]; other site 227882001687 active site 227882001688 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001689 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 227882001690 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882001691 active site 227882001692 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882001693 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882001694 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882001695 putative NADP binding site [chemical binding]; other site 227882001696 active site 227882001697 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001698 Cytochrome P450; Region: p450; cl12078 227882001699 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882001700 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882001701 active site 227882001702 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882001703 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882001704 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882001705 putative NADP binding site [chemical binding]; other site 227882001706 active site 227882001707 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001708 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882001709 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882001710 active site 227882001711 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882001712 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882001713 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882001714 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882001715 putative NADP binding site [chemical binding]; other site 227882001716 active site 227882001717 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001718 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882001719 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882001720 active site 227882001721 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882001722 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882001723 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882001724 putative NADP binding site [chemical binding]; other site 227882001725 active site 227882001726 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001727 Erythronolide synthase docking; Region: Docking; pfam08990 227882001728 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882001729 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882001730 active site 227882001731 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882001732 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882001733 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 227882001734 NADP binding site [chemical binding]; other site 227882001735 active site 227882001736 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001737 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 227882001738 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882001739 active site 227882001740 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882001741 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001742 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882001743 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882001744 active site 227882001745 ribonuclease E; Reviewed; Region: rne; PRK10811 227882001746 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882001747 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882001748 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882001749 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882001750 putative NADP binding site [chemical binding]; other site 227882001751 active site 227882001752 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882001753 Thioesterase; Region: PKS_TE; smart00824 227882001754 classical (c) SDRs; Region: SDR_c; cd05233 227882001755 NAD(P) binding site [chemical binding]; other site 227882001756 active site 227882001757 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 227882001758 glycosyltransferase, MGT family; Region: MGT; TIGR01426 227882001759 active site 227882001760 TDP-binding site; other site 227882001761 acceptor substrate-binding pocket; other site 227882001762 homodimer interface [polypeptide binding]; other site 227882001763 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 227882001764 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 227882001765 NAD binding site [chemical binding]; other site 227882001766 substrate binding site [chemical binding]; other site 227882001767 homodimer interface [polypeptide binding]; other site 227882001768 active site 227882001769 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 227882001770 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 227882001771 substrate binding site [chemical binding]; other site 227882001772 tetramer interface [polypeptide binding]; other site 227882001773 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 227882001774 extended (e) SDRs; Region: SDR_e; cd08946 227882001775 NAD(P) binding site [chemical binding]; other site 227882001776 active site 227882001777 substrate binding site [chemical binding]; other site 227882001778 Cupin domain; Region: Cupin_2; cl09118 227882001779 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 227882001780 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 227882001781 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 227882001782 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 227882001783 active site 227882001784 catalytic tetrad [active] 227882001785 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 227882001786 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882001787 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 227882001788 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 227882001789 active site 227882001790 FMN binding site [chemical binding]; other site 227882001791 substrate binding site [chemical binding]; other site 227882001792 3Fe-4S cluster binding site [ion binding]; other site 227882001793 pyruvate dehydrogenase; Provisional; Region: PRK09124 227882001794 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 227882001795 PYR/PP interface [polypeptide binding]; other site 227882001796 tetramer interface [polypeptide binding]; other site 227882001797 dimer interface [polypeptide binding]; other site 227882001798 TPP binding site [chemical binding]; other site 227882001799 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 227882001800 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014 227882001801 TPP-binding site [chemical binding]; other site 227882001802 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882001803 YCII-related domain; Region: YCII; cl00999 227882001804 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 227882001805 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882001806 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882001807 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 227882001808 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 227882001809 NAD binding site [chemical binding]; other site 227882001810 catalytic Zn binding site [ion binding]; other site 227882001811 structural Zn binding site [ion binding]; other site 227882001812 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882001813 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 227882001814 substrate binding pocket [chemical binding]; other site 227882001815 catalytic residues [active] 227882001816 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 227882001817 TM-ABC transporter signature motif; other site 227882001818 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 227882001819 TM-ABC transporter signature motif; other site 227882001820 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 227882001821 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 227882001822 Walker A/P-loop; other site 227882001823 ATP binding site [chemical binding]; other site 227882001824 Q-loop/lid; other site 227882001825 ABC transporter signature motif; other site 227882001826 Walker B; other site 227882001827 D-loop; other site 227882001828 H-loop/switch region; other site 227882001829 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 227882001830 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 227882001831 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 227882001832 putative ligand binding site [chemical binding]; other site 227882001833 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882001834 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882001835 DNA binding site [nucleotide binding] 227882001836 domain linker motif; other site 227882001837 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 227882001838 dimerization interface [polypeptide binding]; other site 227882001839 ligand binding site [chemical binding]; other site 227882001840 PA14 domain; Region: PA14; cl08459 227882001841 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 227882001842 domain; Region: Glyco_hydro_2; pfam00703 227882001843 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 227882001844 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 227882001845 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882001846 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882001847 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882001848 active site 227882001849 ATP binding site [chemical binding]; other site 227882001850 substrate binding site [chemical binding]; other site 227882001851 activation loop (A-loop); other site 227882001852 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 227882001853 ligand binding site [chemical binding]; other site 227882001854 flexible hinge region; other site 227882001855 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 227882001856 putative transposase OrfB; Reviewed; Region: PHA02517 227882001857 Integrase core domain; Region: rve; cl01316 227882001858 Predicted membrane protein [Function unknown]; Region: COG2364 227882001859 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882001860 DNA-binding site [nucleotide binding]; DNA binding site 227882001861 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 227882001862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882001863 homodimer interface [polypeptide binding]; other site 227882001864 catalytic residue [active] 227882001865 tocopherol O-methyltransferase; Region: PLN02244 227882001866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882001867 DNA mismatch repair protein MutS; Region: mutS1; TIGR01070 227882001868 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882001869 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 227882001870 Walker A motif; other site 227882001871 ATP binding site [chemical binding]; other site 227882001872 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 227882001873 metal ion-dependent adhesion site (MIDAS); other site 227882001874 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 227882001875 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such...; Region: APH_ChoK_like_1; cd05155 227882001876 putative active site [active] 227882001877 putative substrate binding site [chemical binding]; other site 227882001878 ATP binding site [chemical binding]; other site 227882001879 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 227882001880 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 227882001881 metal binding site [ion binding]; metal-binding site 227882001882 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 227882001883 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 227882001884 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882001885 DNA binding residues [nucleotide binding] 227882001886 Peptidase family M48; Region: Peptidase_M48; cl12018 227882001887 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 227882001888 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 227882001889 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 227882001890 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 227882001891 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 227882001892 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001894 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 227882001895 hydrophobic ligand binding site; other site 227882001896 short chain dehydrogenase; Provisional; Region: PRK05872 227882001897 classical (c) SDRs; Region: SDR_c; cd05233 227882001898 NAD(P) binding site [chemical binding]; other site 227882001899 active site 227882001900 FOG: CBS domain [General function prediction only]; Region: COG0517 227882001901 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_9; cd04622 227882001902 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_3; cd03813 227882001903 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 227882001904 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 227882001905 NAD binding site [chemical binding]; other site 227882001906 substrate binding site [chemical binding]; other site 227882001907 active site 227882001908 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001909 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 227882001910 active site 227882001911 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 227882001912 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001913 NAD(P) binding site [chemical binding]; other site 227882001914 active site 227882001915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001916 active site 227882001917 Spherulation-specific family 4; Region: Spherulin4; pfam12138 227882001918 Low affinity iron permease; Region: Iron_permease; cl12096 227882001919 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001920 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 227882001921 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882001922 S-adenosylmethionine binding site [chemical binding]; other site 227882001923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882001924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001925 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 227882001926 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 227882001927 substrate binding pocket [chemical binding]; other site 227882001928 chain length determination region; other site 227882001929 substrate-Mg2+ binding site; other site 227882001930 catalytic residues [active] 227882001931 aspartate-rich region 1; other site 227882001932 active site lid residues [active] 227882001933 aspartate-rich region 2; other site 227882001934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882001935 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 227882001936 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 227882001937 active site lid residues [active] 227882001938 substrate binding pocket [chemical binding]; other site 227882001939 catalytic residues [active] 227882001940 substrate-Mg2+ binding site; other site 227882001941 aspartate-rich region 1; other site 227882001942 aspartate-rich region 2; other site 227882001943 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cl00938 227882001944 iron-sulfur cluster [ion binding]; other site 227882001945 [2Fe-2S] cluster binding site [ion binding]; other site 227882001946 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 227882001947 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cl00126 227882001948 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 227882001949 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 227882001950 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 227882001951 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 227882001952 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882001953 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 227882001954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882001955 conserved gate region; other site 227882001956 dimer interface [polypeptide binding]; other site 227882001957 putative PBP binding loops; other site 227882001958 ABC-ATPase subunit interface; other site 227882001959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882001960 dimer interface [polypeptide binding]; other site 227882001961 conserved gate region; other site 227882001962 putative PBP binding loops; other site 227882001963 ABC-ATPase subunit interface; other site 227882001964 lac repressor; Reviewed; Region: lacI; PRK09526 227882001965 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882001966 DNA binding site [nucleotide binding] 227882001967 domain linker motif; other site 227882001968 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 227882001969 ligand binding site [chemical binding]; other site 227882001970 dimerization interface (open form) [polypeptide binding]; other site 227882001971 dimerization interface (closed form) [polypeptide binding]; other site 227882001972 Predicted membrane protein [Function unknown]; Region: COG1289 227882001973 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 227882001974 short chain dehydrogenase; Provisional; Region: PRK07062 227882001975 classical (c) SDRs; Region: SDR_c; cd05233 227882001976 NAD(P) binding site [chemical binding]; other site 227882001977 active site 227882001978 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 227882001979 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 227882001980 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 227882001981 active site 227882001982 Zn binding site [ion binding]; other site 227882001983 Putative Ig domain; Region: He_PIG; pfam05345 227882001984 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 227882001985 porphobilinogen deaminase; Region: hemC; TIGR00212 227882001986 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 227882001987 domain interfaces; other site 227882001988 active site 227882001989 Beta-lactamase; Region: Beta-lactamase; cl01009 227882001990 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882001991 dimerization interface [polypeptide binding]; other site 227882001992 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882001993 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 227882001994 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 227882001995 active site 227882001996 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 227882001997 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 227882001998 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 227882001999 active site 227882002000 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 227882002001 putative sugar binding sites [chemical binding]; other site 227882002002 Q-X-W motif; other site 227882002003 Predicted membrane protein (DUF2238); Region: DUF2238; cl01464 227882002004 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882002005 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882002006 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 227882002007 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 227882002008 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 227882002009 active site 227882002010 catalytic tetrad [active] 227882002011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882002012 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 227882002013 Leucine carboxyl methyltransferase; Region: LCM; cl01306 227882002014 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 227882002015 substrate binding pocket [chemical binding]; other site 227882002016 catalytic residues [active] 227882002017 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 227882002018 PAS fold; Region: PAS_3; pfam08447 227882002019 putative active site [active] 227882002020 heme pocket [chemical binding]; other site 227882002021 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 227882002022 PAS fold; Region: PAS_4; pfam08448 227882002023 GAF domain; Region: GAF; cl00853 227882002024 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882002025 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 227882002026 GAF domain; Region: GAF; cl00853 227882002027 ANTAR domain; Region: ANTAR; cl04297 227882002028 Transcriptional regulators [Transcription]; Region: MarR; COG1846 227882002029 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882002030 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882002031 Restriction endonuclease; Region: Mrr_cat; cl00747 227882002032 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 227882002033 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 227882002034 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882002035 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 227882002036 catalytic residue [active] 227882002037 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 227882002038 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 227882002039 putative active site [active] 227882002040 catalytic site [active] 227882002041 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 227882002042 putative active site [active] 227882002043 catalytic site [active] 227882002044 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 227882002045 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 227882002046 putative dimer interface [polypeptide binding]; other site 227882002047 N-terminal domain interface [polypeptide binding]; other site 227882002048 putative substrate binding pocket (H-site) [chemical binding]; other site 227882002049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882002050 short chain dehydrogenase; Provisional; Region: PRK12939 227882002051 NAD(P) binding site [chemical binding]; other site 227882002052 active site 227882002053 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882002054 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882002055 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 227882002056 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 227882002057 Uncharacterized conserved protein (DUF2235); Region: DUF2235; cl01480 227882002058 Predicted membrane protein [Function unknown]; Region: COG4270 227882002059 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 227882002060 catalytic triad [active] 227882002061 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and...; Region: XynE_like; cd01830 227882002062 active site 227882002063 catalytic triad [active] 227882002064 oxyanion hole [active] 227882002065 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 227882002066 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 227882002067 Ca binding site [ion binding]; other site 227882002068 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 227882002069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882002070 dimer interface [polypeptide binding]; other site 227882002071 conserved gate region; other site 227882002072 putative PBP binding loops; other site 227882002073 ABC-ATPase subunit interface; other site 227882002074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882002075 dimer interface [polypeptide binding]; other site 227882002076 conserved gate region; other site 227882002077 putative PBP binding loops; other site 227882002078 ABC-ATPase subunit interface; other site 227882002079 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882002080 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882002081 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882002082 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 227882002083 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 227882002084 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 227882002085 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882002086 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 227882002087 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882002088 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882002089 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882002090 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882002091 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882002092 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882002093 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 227882002094 GAF domain; Region: GAF; cl00853 227882002095 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 227882002096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882002097 ATP binding site [chemical binding]; other site 227882002098 Mg2+ binding site [ion binding]; other site 227882002099 G-X-G motif; other site 227882002100 Response regulator receiver domain; Region: Response_reg; pfam00072 227882002101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882002102 active site 227882002103 phosphorylation site [posttranslational modification] 227882002104 intermolecular recognition site; other site 227882002105 dimerization interface [polypeptide binding]; other site 227882002106 ANTAR domain; Region: ANTAR; cl04297 227882002107 putative diguanylate cyclase; Provisional; Region: PRK09776 227882002108 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882002109 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882002110 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 227882002111 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882002112 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 227882002113 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882002114 DNA binding residues [nucleotide binding] 227882002115 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 227882002116 anti sigma factor interaction site; other site 227882002117 regulatory phosphorylation site [posttranslational modification]; other site 227882002118 Transcriptional regulators [Transcription]; Region: MarR; COG1846 227882002119 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882002120 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882002121 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882002122 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 227882002123 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 227882002124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882002125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882002126 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882002127 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882002128 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882002129 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882002130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882002131 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 227882002132 anti sigma factor interaction site; other site 227882002133 regulatory phosphorylation site [posttranslational modification]; other site 227882002134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882002135 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 227882002136 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882002137 hypothetical protein; Provisional; Region: PHA02699 227882002138 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 227882002139 SxDxEG motif; other site 227882002140 active site 227882002141 metal binding site [ion binding]; metal-binding site 227882002142 homopentamer interface [polypeptide binding]; other site 227882002143 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 227882002144 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 227882002145 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 227882002146 active site 227882002147 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 227882002148 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 227882002149 Zn binding site [ion binding]; other site 227882002150 enterobactin exporter EntS; Provisional; Region: PRK10489 227882002151 LysE type translocator; Region: LysE; cl00565 227882002152 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 227882002153 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882002154 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882002155 dimerization interface [polypeptide binding]; other site 227882002156 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 227882002157 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 227882002158 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882002159 uncharacterized xylulose kinase-like proteins, subgroup 1; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 227882002160 N- and C-terminal domain interface [polypeptide binding]; other site 227882002161 D-xylulose kinase; Region: XylB; TIGR01312 227882002162 putative active site [active] 227882002163 catalytic site [active] 227882002164 metal binding site [ion binding]; metal-binding site 227882002165 putative xylulose binding site [chemical binding]; other site 227882002166 putative ATP binding site [chemical binding]; other site 227882002167 putative homodimer interface [polypeptide binding]; other site 227882002168 Protein of unknown function DUF124; Region: DUF124; cl00884 227882002169 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 227882002170 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 227882002171 active site 227882002172 Zn binding site [ion binding]; other site 227882002173 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 227882002174 substrate binding pocket [chemical binding]; other site 227882002175 chain length determination region; other site 227882002176 substrate-Mg2+ binding site; other site 227882002177 catalytic residues [active] 227882002178 aspartate-rich region 1; other site 227882002179 active site lid residues [active] 227882002180 aspartate-rich region 2; other site 227882002181 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 227882002182 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882002183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882002184 putative substrate translocation pore; other site 227882002185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882002186 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 227882002187 Tyrosinase co-factor MelC1; Region: MelC1; pfam06236 227882002188 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 227882002189 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 227882002190 RNA/DNA hybrid binding site [nucleotide binding]; other site 227882002191 active site 227882002192 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882002193 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 227882002194 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 227882002195 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 227882002196 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 227882002197 NAD(P) binding site [chemical binding]; other site 227882002198 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882002199 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882002200 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; cl06815 227882002201 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 227882002202 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 227882002203 dimer interface [polypeptide binding]; other site 227882002204 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 227882002205 oligomer interface [polypeptide binding]; other site 227882002206 active site residues [active] 227882002207 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 227882002208 oligomer interface [polypeptide binding]; other site 227882002209 active site residues [active] 227882002210 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882002211 FG-GAP repeat; Region: FG-GAP; cl15299 227882002212 FG-GAP repeat; Region: FG-GAP; cl15299 227882002213 FG-GAP repeat; Region: FG-GAP; cl15299 227882002214 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 227882002215 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882002216 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 227882002217 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882002218 DNA binding residues [nucleotide binding] 227882002219 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 227882002220 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 227882002221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882002222 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 227882002223 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882002224 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882002225 Catalytic domain of Protein Kinases; Region: PKc; cd00180 227882002226 active site 227882002227 ATP binding site [chemical binding]; other site 227882002228 substrate binding site [chemical binding]; other site 227882002229 activation loop (A-loop); other site 227882002230 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 227882002231 phosphopeptide binding site; other site 227882002232 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 227882002233 phosphopeptide binding site; other site 227882002234 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with...; Region: ABCG_EPDR; cd03213 227882002235 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 227882002236 Walker A/P-loop; other site 227882002237 ATP binding site [chemical binding]; other site 227882002238 Q-loop/lid; other site 227882002239 ABC transporter signature motif; other site 227882002240 Walker B; other site 227882002241 D-loop; other site 227882002242 H-loop/switch region; other site 227882002243 ABC-2 type transporter; Region: ABC2_membrane; cl11417 227882002244 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 227882002245 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 227882002246 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 227882002247 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 227882002248 active site 227882002249 catalytic tetrad [active] 227882002250 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882002251 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 227882002252 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 227882002253 putative dimerization interface [polypeptide binding]; other site 227882002254 DinB superfamily; Region: DinB_2; cl00986 227882002255 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 227882002256 active site 227882002257 purine riboside binding site [chemical binding]; other site 227882002258 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 227882002259 Peptidase family M48; Region: Peptidase_M48; cl12018 227882002260 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882002261 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 227882002262 active site 227882002263 Membrane transport protein; Region: Mem_trans; cl09117 227882002264 Cytochrome P450; Region: p450; cl12078 227882002265 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 227882002266 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 227882002267 active site 227882002268 catalytic tetrad [active] 227882002269 Catalytic domain of Arabidopsis thaliana PI-PLC X domain-containing protein At5g67130 and its uncharacterized homologs; Region: PI-PLCc_At5g67130_like; cd08588 227882002270 putative active site [active] 227882002271 catalytic site [active] 227882002272 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 227882002273 substrate-cofactor binding pocket; other site 227882002274 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882002275 catalytic residue [active] 227882002276 benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262 227882002277 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882002278 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 227882002279 Glutamine amidotransferase class-I; Region: GATase; pfam00117 227882002280 glutamine binding [chemical binding]; other site 227882002281 catalytic triad [active] 227882002282 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 227882002283 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 227882002284 chorismate binding enzyme; Region: Chorismate_bind; cl10555 227882002285 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 227882002286 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 227882002287 Protein of unknown function (DUF1036); Region: DUF1036; cl02296 227882002288 YceI-like domain; Region: YceI; cl01001 227882002289 Transcriptional regulators [Transcription]; Region: MarR; COG1846 227882002290 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882002291 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882002292 dimerization interface [polypeptide binding]; other site 227882002293 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 227882002294 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 227882002295 NAD(P) binding site [chemical binding]; other site 227882002296 catalytic residues [active] 227882002297 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882002298 Type I periplasmic-binding protein of the nitrile hydratase (NHase) system that selectively converts nitriles to corresponding amides; Region: PBP1_NHase; cd06358 227882002299 putative ligand binding site [chemical binding]; other site 227882002300 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 227882002301 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 227882002302 putative ligand binding site [chemical binding]; other site 227882002303 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 227882002304 TM-ABC transporter signature motif; other site 227882002305 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 227882002306 TM-ABC transporter signature motif; other site 227882002307 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 227882002308 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 227882002309 Walker A/P-loop; other site 227882002310 ATP binding site [chemical binding]; other site 227882002311 Q-loop/lid; other site 227882002312 ABC transporter signature motif; other site 227882002313 Walker B; other site 227882002314 D-loop; other site 227882002315 H-loop/switch region; other site 227882002316 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 227882002317 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 227882002318 Walker A/P-loop; other site 227882002319 ATP binding site [chemical binding]; other site 227882002320 Q-loop/lid; other site 227882002321 ABC transporter signature motif; other site 227882002322 Walker B; other site 227882002323 D-loop; other site 227882002324 H-loop/switch region; other site 227882002325 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 227882002326 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882002327 YCII-related domain; Region: YCII; cl00999 227882002328 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882002329 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 227882002330 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 227882002331 conserved cys residue [active] 227882002332 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882002333 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882002334 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 227882002335 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 227882002336 putative NAD(P) binding site [chemical binding]; other site 227882002337 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 227882002338 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 227882002339 putative NAD(P) binding site [chemical binding]; other site 227882002340 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 227882002341 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882002342 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 227882002343 Integrase core domain; Region: rve; cl01316 227882002344 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 227882002345 active site 227882002346 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 227882002347 dimer interface [polypeptide binding]; other site 227882002348 non-prolyl cis peptide bond; other site 227882002349 insertion regions; other site 227882002350 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 227882002351 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882002352 active site 227882002353 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 227882002354 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 227882002355 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 227882002356 active site 227882002357 dimer interface [polypeptide binding]; other site 227882002358 non-prolyl cis peptide bond; other site 227882002359 insertion regions; other site 227882002360 Transcriptional regulator [Transcription]; Region: LysR; COG0583 227882002361 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882002362 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 227882002363 dimerization interface [polypeptide binding]; other site 227882002364 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 227882002365 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 227882002366 putative NAD(P) binding site [chemical binding]; other site 227882002367 putative active site [active] 227882002368 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 227882002369 DNA photolyase; Region: DNA_photolyase; pfam00875 227882002370 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 227882002371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882002372 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 227882002373 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 227882002374 DNA binding residues [nucleotide binding] 227882002375 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 227882002376 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 227882002377 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882002378 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882002379 DNA binding residues [nucleotide binding] 227882002380 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 227882002381 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 227882002382 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 227882002383 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882002384 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882002385 SPW repeat; Region: SPW; pfam03779 227882002386 SPW repeat; Region: SPW; pfam03779 227882002387 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 227882002388 active site 227882002389 ATP binding site [chemical binding]; other site 227882002390 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882002391 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882002392 N-acetylmannosamine kinase; Provisional; Region: PRK05082 227882002393 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 227882002394 domain; Region: Glyco_hydro_2; pfam00703 227882002395 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 227882002396 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882002397 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 227882002398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 227882002399 Coenzyme A binding pocket [chemical binding]; other site 227882002400 Small secreted domain (DUF320); Region: DUF320; pfam03777 227882002401 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 227882002402 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882002403 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 227882002404 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 227882002405 active site 227882002406 FMN binding site [chemical binding]; other site 227882002407 substrate binding site [chemical binding]; other site 227882002408 3Fe-4S cluster binding site [ion binding]; other site 227882002409 peptide chain release factor eRF/aRF, subunit 1; Region: eRF; TIGR00108 227882002410 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 227882002411 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882002412 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 227882002413 putative diguanylate cyclase; Provisional; Region: PRK09776 227882002414 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 227882002415 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882002416 Phosphotransferase enzyme family; Region: APH; pfam01636 227882002417 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 227882002418 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 227882002419 amidase catalytic site [active] 227882002420 Zn binding residues [ion binding]; other site 227882002421 substrate binding site [chemical binding]; other site 227882002422 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882002423 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 227882002424 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 227882002425 active site 227882002426 lipid-transfer protein; Provisional; Region: PRK07937 227882002427 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 227882002428 active site 227882002429 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 227882002430 DUF35 OB-fold domain; Region: DUF35; pfam01796 227882002431 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 227882002432 DUF35 OB-fold domain; Region: DUF35; pfam01796 227882002433 enoyl-CoA hydratase; Provisional; Region: PRK07799 227882002434 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 227882002435 substrate binding site [chemical binding]; other site 227882002436 oxyanion hole (OAH) forming residues; other site 227882002437 trimer interface [polypeptide binding]; other site 227882002438 acyl-CoA synthetase; Validated; Region: PRK07798 227882002439 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882002440 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882002441 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 227882002442 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 227882002443 active site 227882002444 metal binding site [ion binding]; metal-binding site 227882002445 hexamer interface [polypeptide binding]; other site 227882002446 GAF domain; Region: GAF; cl00853 227882002447 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882002448 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882002449 active site 227882002450 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882002451 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 227882002452 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882002453 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 227882002454 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882002455 Nitrate and nitrite sensing; Region: NIT; pfam08376 227882002456 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 227882002457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882002458 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 227882002459 Protein of unknown function (DUF742); Region: DUF742; pfam05331 227882002460 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 227882002461 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 227882002462 G1 box; other site 227882002463 GTP/Mg2+ binding site [chemical binding]; other site 227882002464 G2 box; other site 227882002465 Switch I region; other site 227882002466 G3 box; other site 227882002467 Switch II region; other site 227882002468 G4 box; other site 227882002469 G5 box; other site 227882002470 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882002471 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882002472 acyl-CoA synthetase; Validated; Region: PRK08316 227882002473 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882002474 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 227882002475 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882002476 Nitronate monooxygenase; Region: NMO; pfam03060 227882002477 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 227882002478 FMN binding site [chemical binding]; other site 227882002479 substrate binding site [chemical binding]; other site 227882002480 putative catalytic residue [active] 227882002481 Beta-lactamase; Region: Beta-lactamase; cl01009 227882002482 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 227882002483 hypothetical protein; Provisional; Region: PRK06185 227882002484 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882002485 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882002486 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 227882002487 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882002488 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882002489 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882002490 active site 227882002491 ATP binding site [chemical binding]; other site 227882002492 substrate binding site [chemical binding]; other site 227882002493 activation loop (A-loop); other site 227882002494 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 227882002495 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 227882002496 binding surface 227882002497 TPR motif; other site 227882002498 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 227882002499 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 227882002500 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882002501 active site 227882002502 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 227882002503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882002504 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 227882002505 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 227882002506 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 227882002507 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 227882002508 catalytic Zn binding site [ion binding]; other site 227882002509 structural Zn binding site [ion binding]; other site 227882002510 NAD(P) binding site [chemical binding]; other site 227882002511 putative phosphoketolase; Provisional; Region: PRK05261 227882002512 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 227882002513 TPP-binding site; other site 227882002514 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 227882002515 XFP C-terminal domain; Region: XFP_C; pfam09363 227882002516 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 227882002517 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 227882002518 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 227882002519 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 227882002520 ligand binding site [chemical binding]; other site 227882002521 flexible hinge region; other site 227882002522 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 227882002523 Leucine carboxyl methyltransferase; Region: LCM; cl01306 227882002524 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882002525 NAD(P) binding site [chemical binding]; other site 227882002526 active site 227882002527 Histidine kinase; Region: HisKA_3; pfam07730 227882002528 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882002529 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882002530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882002531 active site 227882002532 phosphorylation site [posttranslational modification] 227882002533 intermolecular recognition site; other site 227882002534 dimerization interface [polypeptide binding]; other site 227882002535 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882002536 DNA binding residues [nucleotide binding] 227882002537 dimerization interface [polypeptide binding]; other site 227882002538 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 227882002539 Protein of unknown function (DUF418); Region: DUF418; cl12135 227882002540 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 227882002541 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 227882002542 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 227882002543 DAK2 domain; Region: Dak2; cl03685 227882002544 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cl00025 227882002545 Fungal chitosanase; Region: Chitosanase; pfam07335 227882002546 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 227882002547 Interdomain contacts; other site 227882002548 Cytokine receptor motif; other site 227882002549 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882002550 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 227882002551 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 227882002552 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 227882002553 active site 227882002554 FMN binding site [chemical binding]; other site 227882002555 2,4-decadienoyl-CoA binding site; other site 227882002556 catalytic residue [active] 227882002557 4Fe-4S cluster binding site [ion binding]; other site 227882002558 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 227882002559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882002560 Predicted membrane protein [Function unknown]; Region: COG1511 227882002561 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882002562 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882002563 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 227882002564 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 227882002565 putative NAD(P) binding site [chemical binding]; other site 227882002566 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 227882002567 Moco binding site; other site 227882002568 metal coordination site [ion binding]; other site 227882002569 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 227882002570 FAD binding pocket [chemical binding]; other site 227882002571 FAD binding motif [chemical binding]; other site 227882002572 phosphate binding motif [ion binding]; other site 227882002573 beta-alpha-beta structure motif; other site 227882002574 NAD binding pocket [chemical binding]; other site 227882002575 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 227882002576 Ligand Binding Site [chemical binding]; other site 227882002577 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 227882002578 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882002579 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 227882002580 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 227882002581 Beta-lactamase; Region: Beta-lactamase; cl01009 227882002582 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 227882002583 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882002584 DNA-binding site [nucleotide binding]; DNA binding site 227882002585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882002586 S-adenosylmethionine binding site [chemical binding]; other site 227882002587 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 227882002588 trehalose synthase; Region: treS_nterm; TIGR02456 227882002589 Cytochrome P450; Region: p450; cl12078 227882002590 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 227882002591 Flavin binding site [chemical binding]; other site 227882002592 transcription termination factor Rho; Provisional; Region: PRK12608 227882002593 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 227882002594 RNA binding site [nucleotide binding]; other site 227882002595 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882002596 Walker A motif; other site 227882002597 ATP binding site [chemical binding]; other site 227882002598 Walker B motif; other site 227882002599 Beta-lactamase; Region: Beta-lactamase; cl01009 227882002600 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 227882002601 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 227882002602 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 227882002603 Glutaminase; Region: Glutaminase; cl00907 227882002604 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 227882002605 Aspartase; Region: Aspartase; cd01357 227882002606 active sites [active] 227882002607 tetramer interface [polypeptide binding]; other site 227882002608 L-asparaginase II; Region: Asparaginase_II; cl01842 227882002609 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882002610 Amino acid permease; Region: AA_permease; pfam00324 227882002611 Transcriptional regulators [Transcription]; Region: FadR; COG2186 227882002612 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882002613 DNA-binding site [nucleotide binding]; DNA binding site 227882002614 FCD domain; Region: FCD; cl11656 227882002615 Bacitracin resistance protein BacA; Region: BacA; cl00858 227882002616 CrcB-like protein; Region: CRCB; cl09114 227882002617 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 227882002618 CrcB-like protein; Region: CRCB; cl09114 227882002619 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 227882002620 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 227882002621 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 227882002622 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 227882002623 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 227882002624 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882002625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 227882002626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882002627 dimer interface [polypeptide binding]; other site 227882002628 conserved gate region; other site 227882002629 putative PBP binding loops; other site 227882002630 ABC-ATPase subunit interface; other site 227882002631 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882002632 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882002633 DNA binding site [nucleotide binding] 227882002634 domain linker motif; other site 227882002635 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 227882002636 putative dimerization interface [polypeptide binding]; other site 227882002637 putative ligand binding site [chemical binding]; other site 227882002638 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 227882002639 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882002640 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 227882002641 FAD binding domain; Region: FAD_binding_4; pfam01565 227882002642 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882002643 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882002644 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 227882002645 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 227882002646 active site residue [active] 227882002647 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 227882002648 active site residue [active] 227882002649 NMT1/THI5 like; Region: NMT1; pfam09084 227882002650 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cl15306 227882002651 NMT1/THI5 like; Region: NMT1; pfam09084 227882002652 substrate binding pocket [chemical binding]; other site 227882002653 membrane-bound complex binding site; other site 227882002654 hinge residues; other site 227882002655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 227882002656 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 227882002657 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 227882002658 Walker A/P-loop; other site 227882002659 ATP binding site [chemical binding]; other site 227882002660 Q-loop/lid; other site 227882002661 ABC transporter signature motif; other site 227882002662 Walker B; other site 227882002663 D-loop; other site 227882002664 H-loop/switch region; other site 227882002665 Phosphotransferase enzyme family; Region: APH; pfam01636 227882002666 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882002667 substrate binding site [chemical binding]; other site 227882002668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882002669 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 227882002670 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 227882002671 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882002672 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 227882002673 AMP-binding enzyme; Region: AMP-binding; pfam00501 227882002674 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882002675 acyl-coenzyme A oxidase; Region: PLN02526 227882002676 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882002677 active site 227882002678 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 227882002679 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 227882002680 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 227882002681 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 227882002682 enoyl-CoA hydratase; Provisional; Region: PRK08252 227882002683 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 227882002684 substrate binding site [chemical binding]; other site 227882002685 oxyanion hole (OAH) forming residues; other site 227882002686 trimer interface [polypeptide binding]; other site 227882002687 CoA-transferase family III; Region: CoA_transf_3; cl00778 227882002688 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 227882002689 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882002690 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 227882002691 substrate binding pocket [chemical binding]; other site 227882002692 dimerization interface [polypeptide binding]; other site 227882002693 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 227882002694 sugar binding site [chemical binding]; other site 227882002695 glycosyl hydrolase 64 family; Region: GH64-like; cd09214 227882002696 substrate binding pocket [chemical binding]; other site 227882002697 catalytic residues [active] 227882002698 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 227882002699 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882002700 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 227882002701 active site 227882002702 catalytic triad [active] 227882002703 dimer interface [polypeptide binding]; other site 227882002704 Transcriptional regulators [Transcription]; Region: FadR; COG2186 227882002705 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882002706 DNA-binding site [nucleotide binding]; DNA binding site 227882002707 FCD domain; Region: FCD; cl11656 227882002708 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 227882002709 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 227882002710 putative NAD(P) binding site [chemical binding]; other site 227882002711 putative substrate binding site [chemical binding]; other site 227882002712 catalytic Zn binding site [ion binding]; other site 227882002713 structural Zn binding site [ion binding]; other site 227882002714 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 227882002715 NAD binding site [chemical binding]; other site 227882002716 substrate binding site [chemical binding]; other site 227882002717 putative active site [active] 227882002718 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882002719 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882002720 Predicted transcriptional regulator [Transcription]; Region: COG1959 227882002721 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882002722 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882002723 NAD(P) binding site [chemical binding]; other site 227882002724 active site 227882002725 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 227882002726 heme-binding site [chemical binding]; other site 227882002727 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 227882002728 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 227882002729 active site 227882002730 Zn binding site [ion binding]; other site 227882002731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882002732 NAD(P) binding site [chemical binding]; other site 227882002733 active site 227882002734 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 227882002735 Prostaglandin dehydrogenases; Region: PGDH; cd05288 227882002736 NAD(P) binding site [chemical binding]; other site 227882002737 substrate binding site [chemical binding]; other site 227882002738 dimer interface [polypeptide binding]; other site 227882002739 Protein of unknown function, DUF485; Region: DUF485; cl01231 227882002740 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 227882002741 Sodium:solute symporter family; Region: SSF; cl00456 227882002742 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 227882002743 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 227882002744 conserved cys residue [active] 227882002745 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882002746 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882002747 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 227882002748 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 227882002749 PYR/PP interface [polypeptide binding]; other site 227882002750 dimer interface [polypeptide binding]; other site 227882002751 TPP binding site [chemical binding]; other site 227882002752 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 227882002753 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cd00568 227882002754 TPP-binding site [chemical binding]; other site 227882002755 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 227882002756 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 227882002757 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 227882002758 active site 227882002759 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 227882002760 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 227882002761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882002762 homodimer interface [polypeptide binding]; other site 227882002763 catalytic residue [active] 227882002764 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 227882002765 DinB superfamily; Region: DinB_2; cl00986 227882002766 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 227882002767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882002768 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882002769 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882002770 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 227882002771 classical (c) SDRs; Region: SDR_c; cd05233 227882002772 NAD(P) binding site [chemical binding]; other site 227882002773 active site 227882002774 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 227882002775 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882002776 active site 227882002777 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882002778 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882002779 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882002780 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 227882002781 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 227882002782 dimer interface [polypeptide binding]; other site 227882002783 active site 227882002784 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 227882002785 putative heme binding pocket [chemical binding]; other site 227882002786 FAD binding domain; Region: FAD_binding_4; pfam01565 227882002787 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 227882002788 Transcriptional regulators [Transcription]; Region: FadR; COG2186 227882002789 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882002790 DNA-binding site [nucleotide binding]; DNA binding site 227882002791 FCD domain; Region: FCD; cl11656 227882002792 Isochorismatase family; Region: Isochorismatase; pfam00857 227882002793 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 227882002794 catalytic triad [active] 227882002795 conserved cis-peptide bond; other site 227882002796 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 227882002797 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 227882002798 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 227882002799 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 227882002800 PAS fold; Region: PAS_4; pfam08448 227882002801 GAF domain; Region: GAF; cl00853 227882002802 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882002803 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882002804 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 227882002805 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 227882002806 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 227882002807 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 227882002808 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 227882002809 NAD binding site [chemical binding]; other site 227882002810 substrate binding site [chemical binding]; other site 227882002811 catalytic Zn binding site [ion binding]; other site 227882002812 structural Zn binding site [ion binding]; other site 227882002813 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882002814 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 227882002815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882002816 dimer interface [polypeptide binding]; other site 227882002817 conserved gate region; other site 227882002818 putative PBP binding loops; other site 227882002819 ABC-ATPase subunit interface; other site 227882002820 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 227882002821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882002822 dimer interface [polypeptide binding]; other site 227882002823 conserved gate region; other site 227882002824 putative PBP binding loops; other site 227882002825 ABC-ATPase subunit interface; other site 227882002826 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 227882002827 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 227882002828 Walker A/P-loop; other site 227882002829 ATP binding site [chemical binding]; other site 227882002830 Q-loop/lid; other site 227882002831 ABC transporter signature motif; other site 227882002832 Walker B; other site 227882002833 D-loop; other site 227882002834 H-loop/switch region; other site 227882002835 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 227882002836 ABC Carbohydrate and Solute Transporters-like subgroup. This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols. ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259 227882002837 Walker A/P-loop; other site 227882002838 ATP binding site [chemical binding]; other site 227882002839 Q-loop/lid; other site 227882002840 ABC transporter signature motif; other site 227882002841 Walker B; other site 227882002842 D-loop; other site 227882002843 H-loop/switch region; other site 227882002844 TOBE domain; Region: TOBE_2; cl01440 227882002845 eukaryotic translation initiation factor 2 gamma subunit; Provisional; Region: PTZ00327 227882002846 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 227882002847 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 227882002848 active site 227882002849 catalytic tetrad [active] 227882002850 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 227882002851 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 227882002852 Transcriptional regulators [Transcription]; Region: FadR; COG2186 227882002853 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882002854 DNA-binding site [nucleotide binding]; DNA binding site 227882002855 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 227882002856 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 227882002857 sugar binding site [chemical binding]; other site 227882002858 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 227882002859 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 227882002860 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cd00057 227882002861 sugar binding site [chemical binding]; other site 227882002862 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 227882002863 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 4. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved...; Region: MR_like_4; cd03329 227882002864 putative active site pocket [active] 227882002865 metal binding site [ion binding]; metal-binding site 227882002866 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 227882002867 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882002868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882002869 dimer interface [polypeptide binding]; other site 227882002870 conserved gate region; other site 227882002871 putative PBP binding loops; other site 227882002872 ABC-ATPase subunit interface; other site 227882002873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882002874 dimer interface [polypeptide binding]; other site 227882002875 conserved gate region; other site 227882002876 putative PBP binding loops; other site 227882002877 ABC-ATPase subunit interface; other site 227882002878 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 227882002879 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 227882002880 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882002881 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 227882002882 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882002883 metabolite-proton symporter; Region: 2A0106; TIGR00883 227882002884 putative substrate translocation pore; other site 227882002885 GAF domain; Region: GAF; cl00853 227882002886 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 227882002887 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 227882002888 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882002889 NAD(P) binding site [chemical binding]; other site 227882002890 active site 227882002891 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 227882002892 nudix motif; other site 227882002893 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 227882002894 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 227882002895 putative active site [active] 227882002896 catalytic triad [active] 227882002897 putative dimer interface [polypeptide binding]; other site 227882002898 O-Antigen ligase; Region: Wzy_C; cl04850 227882002899 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 227882002900 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 227882002901 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 227882002902 active site 227882002903 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 227882002904 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 227882002905 putative metal binding site [ion binding]; other site 227882002906 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 227882002907 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 227882002908 putative metal binding site [ion binding]; other site 227882002909 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 227882002910 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 227882002911 MOSC domain; Region: MOSC; pfam03473 227882002912 Domain present in carbohydrate binding proteins and sugar hydrolses; Region: CASH; smart00722 227882002913 stage V sporulation protein K; Region: spore_V_K; TIGR02881 227882002914 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882002915 Walker A motif; other site 227882002916 ATP binding site [chemical binding]; other site 227882002917 Walker B motif; other site 227882002918 arginine finger; other site 227882002919 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 227882002920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882002921 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 227882002922 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 227882002923 putative hydrophobic ligand binding site [chemical binding]; other site 227882002924 protein interface [polypeptide binding]; other site 227882002925 gate; other site 227882002926 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 227882002927 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 227882002928 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 227882002929 catalytic residue [active] 227882002930 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882002931 Predicted membrane protein (DUF2078); Region: DUF2078; cl01373 227882002932 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882002933 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882002934 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: Php; COG1735 227882002935 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 227882002936 active site 227882002937 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 227882002938 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882002939 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 227882002940 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 227882002941 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882002942 S-adenosylmethionine binding site [chemical binding]; other site 227882002943 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 227882002944 intersubunit interface [polypeptide binding]; other site 227882002945 active site 227882002946 zinc binding site [ion binding]; other site 227882002947 Na+ binding site [ion binding]; other site 227882002948 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 227882002949 dimer interface [polypeptide binding]; other site 227882002950 active site 227882002951 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 227882002952 dimer interface [polypeptide binding]; other site 227882002953 active site 227882002954 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 227882002955 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882002956 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 227882002957 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 227882002958 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882002959 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 227882002960 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 227882002961 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 227882002962 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 227882002963 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 227882002964 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 227882002965 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 227882002966 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 227882002967 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; cl10042 227882002968 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 227882002969 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 227882002970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882002971 dimer interface [polypeptide binding]; other site 227882002972 ABC-ATPase subunit interface; other site 227882002973 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 227882002974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882002975 dimer interface [polypeptide binding]; other site 227882002976 conserved gate region; other site 227882002977 putative PBP binding loops; other site 227882002978 ABC-ATPase subunit interface; other site 227882002979 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 227882002980 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 227882002981 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 227882002982 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 227882002983 Predicted ATPase [General function prediction only]; Region: COG3899 227882002984 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 227882002985 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 227882002986 binding surface 227882002987 TPR motif; other site 227882002988 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882002989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882002990 Major Facilitator Superfamily; Region: MFS_1; pfam07690 227882002991 putative substrate translocation pore; other site 227882002992 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882002993 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882002994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882002995 active site 227882002996 phosphorylation site [posttranslational modification] 227882002997 intermolecular recognition site; other site 227882002998 dimerization interface [polypeptide binding]; other site 227882002999 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882003000 DNA binding residues [nucleotide binding] 227882003001 dimerization interface [polypeptide binding]; other site 227882003002 Histidine kinase; Region: HisKA_3; pfam07730 227882003003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882003004 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882003005 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273 227882003006 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 227882003007 putative NAD(P) binding site [chemical binding]; other site 227882003008 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882003009 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882003010 Domain of unknown function (DUF385); Region: DUF385; cl04387 227882003011 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 227882003012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882003013 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 227882003014 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 227882003015 active site 227882003016 metal binding site [ion binding]; metal-binding site 227882003017 dimer interface [polypeptide binding]; other site 227882003018 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 227882003019 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882003020 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 227882003021 nudix motif; other site 227882003022 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 227882003023 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 227882003024 NPCBM/NEW2 domain; Region: NPCBM; cl07060 227882003025 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882003026 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882003027 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882003028 DNA binding site [nucleotide binding] 227882003029 domain linker motif; other site 227882003030 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 227882003031 ligand binding site [chemical binding]; other site 227882003032 dimerization interface [polypeptide binding]; other site 227882003033 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 227882003034 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 227882003035 putative catalytic site [active] 227882003036 putative metal binding site [ion binding]; other site 227882003037 putative phosphate binding site [ion binding]; other site 227882003038 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 227882003039 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 227882003040 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 227882003041 Electron transfer flavoprotein, beta subunit [Energy production and conversion]; Region: FixA; COG2086 227882003042 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 227882003043 Ligand binding site [chemical binding]; other site 227882003044 Flavin Reductases; Region: FlaRed; cl00801 227882003045 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 227882003046 catalytic residues [active] 227882003047 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 227882003048 putative acyl-acceptor binding pocket; other site 227882003049 B3/4 domain; Region: B3_4; cl11458 227882003050 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 227882003051 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 227882003052 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 227882003053 tetramer interface [polypeptide binding]; other site 227882003054 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882003055 catalytic residue [active] 227882003056 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882003057 active site 227882003058 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 227882003059 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 227882003060 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 227882003061 active site 227882003062 catalytic site [active] 227882003063 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 227882003064 Coenzyme A binding pocket [chemical binding]; other site 227882003065 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 227882003066 active site 227882003067 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 227882003068 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 227882003069 Cupin domain; Region: Cupin_2; cl09118 227882003070 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882003071 Peptidase family M48; Region: Peptidase_M48; cl12018 227882003072 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 227882003073 active site 227882003074 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 227882003075 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 227882003076 motif II; other site 227882003077 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 227882003078 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882003079 Uncharacterized conserved protein [Function unknown]; Region: COG5276 227882003080 Domain of unknown function (DUF305); Region: DUF305; pfam03713 227882003081 Domain of unknown function (DUF305); Region: DUF305; pfam03713 227882003082 ferredoxin-NADP+ reductase; Region: PLN02852 227882003083 Permease family; Region: Xan_ur_permease; pfam00860 227882003084 Sulfate transporter family; Region: Sulfate_transp; cl00967 227882003085 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882003086 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 227882003087 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 227882003088 active site 227882003089 FMN binding site [chemical binding]; other site 227882003090 substrate binding site [chemical binding]; other site 227882003091 homotetramer interface [polypeptide binding]; other site 227882003092 catalytic residue [active] 227882003093 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 227882003094 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 227882003095 substrate binding site [chemical binding]; other site 227882003096 ATP binding site [chemical binding]; other site 227882003097 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 227882003098 malate dehydrogenase; Provisional; Region: PRK13529 227882003099 Malic enzyme, N-terminal domain; Region: malic; pfam00390 227882003100 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 227882003101 NAD(P) binding site [chemical binding]; other site 227882003102 Membrane transport protein; Region: Mem_trans; cl09117 227882003103 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 227882003104 Transcriptional regulator [Transcription]; Region: LysR; COG0583 227882003105 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882003106 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882003107 dimerization interface [polypeptide binding]; other site 227882003108 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 227882003109 classical (c) SDRs; Region: SDR_c; cd05233 227882003110 NAD(P) binding site [chemical binding]; other site 227882003111 active site 227882003112 D-cysteine desulfhydrase; Validated; Region: PRK03910 227882003113 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 227882003114 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 227882003115 catalytic residue [active] 227882003116 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 227882003117 CGNR zinc finger; Region: zf-CGNR; pfam11706 227882003118 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 227882003119 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882003120 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882003121 Muconolactone delta-isomerase; Region: MIase; cl01992 227882003122 Transcriptional regulator [Transcription]; Region: LysR; COG0583 227882003123 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882003124 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 227882003125 ligand binding site [chemical binding]; other site 227882003126 active site 227882003127 UGI interface [polypeptide binding]; other site 227882003128 catalytic site [active] 227882003129 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882003130 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 227882003131 Nitric oxide synthase (NOS) prokaryotic oxygenase domain. NOS produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(...; Region: NOS_oxygenase_prok; cd00794 227882003132 active site 227882003133 dimer interface [polypeptide binding]; other site 227882003134 ANTAR domain; Region: ANTAR; cl04297 227882003135 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 227882003136 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882003137 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 227882003138 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 227882003139 active site 227882003140 motif I; other site 227882003141 motif II; other site 227882003142 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 227882003143 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 227882003144 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 227882003145 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 227882003146 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 227882003147 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 227882003148 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 227882003149 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 227882003150 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 227882003151 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 227882003152 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882003153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882003154 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 227882003155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882003156 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 227882003157 Acyltransferase family; Region: Acyl_transf_3; pfam01757 227882003158 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 227882003159 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 227882003160 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 227882003161 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 227882003162 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882003163 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 227882003164 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882003165 NAD(P) binding site [chemical binding]; other site 227882003166 active site 227882003167 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882003168 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882003169 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882003170 active site 227882003171 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882003172 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882003173 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882003174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882003175 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 227882003176 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882003177 putative NADP binding site [chemical binding]; other site 227882003178 active site 227882003179 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882003180 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 227882003181 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882003182 active site 227882003183 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882003184 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882003185 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 227882003186 putative NADP binding site [chemical binding]; other site 227882003187 active site 227882003188 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882003189 Condensation domain; Region: Condensation; cl09290 227882003190 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 227882003191 FkbH-like domain; Region: FkbH; TIGR01686 227882003192 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882003193 peptide synthase; Validated; Region: PRK05691 227882003194 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882003195 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882003196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882003197 S-adenosylmethionine binding site [chemical binding]; other site 227882003198 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882003199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882003200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882003201 putative substrate translocation pore; other site 227882003202 monocarboxylate transporter 1; Region: 2A0113; TIGR00892 227882003203 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 227882003204 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 227882003205 conserved cys residue [active] 227882003206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882003207 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882003208 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 227882003209 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 227882003210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882003211 dimer interface [polypeptide binding]; other site 227882003212 conserved gate region; other site 227882003213 putative PBP binding loops; other site 227882003214 ABC-ATPase subunit interface; other site 227882003215 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 227882003216 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 227882003217 Walker A/P-loop; other site 227882003218 ATP binding site [chemical binding]; other site 227882003219 Q-loop/lid; other site 227882003220 ABC transporter signature motif; other site 227882003221 Walker B; other site 227882003222 D-loop; other site 227882003223 H-loop/switch region; other site 227882003224 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 227882003225 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 227882003226 substrate binding pocket [chemical binding]; other site 227882003227 membrane-bound complex binding site; other site 227882003228 hinge residues; other site 227882003229 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 227882003230 active site 227882003231 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 227882003232 dimer interface [polypeptide binding]; other site 227882003233 non-prolyl cis peptide bond; other site 227882003234 insertion regions; other site 227882003235 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 227882003236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882003237 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 227882003238 dimerization interface [polypeptide binding]; other site 227882003239 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 227882003240 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 227882003241 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 227882003242 Walker A/P-loop; other site 227882003243 ATP binding site [chemical binding]; other site 227882003244 Q-loop/lid; other site 227882003245 ABC transporter signature motif; other site 227882003246 Walker B; other site 227882003247 D-loop; other site 227882003248 H-loop/switch region; other site 227882003249 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882003250 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 227882003251 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A; Region: PNGaseA; pfam12222 227882003252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 227882003253 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 227882003254 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882003255 Q-loop/lid; other site 227882003256 ABC transporter signature motif; other site 227882003257 Walker B; other site 227882003258 D-loop; other site 227882003259 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 227882003260 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 227882003261 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882003262 Walker A/P-loop; other site 227882003263 ATP binding site [chemical binding]; other site 227882003264 Q-loop/lid; other site 227882003265 ABC transporter signature motif; other site 227882003266 Walker B; other site 227882003267 D-loop; other site 227882003268 H-loop/switch region; other site 227882003269 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 227882003270 ski2-like helicase; Provisional; Region: PRK02362 227882003271 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 227882003272 ATP binding site [chemical binding]; other site 227882003273 putative Mg++ binding site [ion binding]; other site 227882003274 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882003275 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 227882003276 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 227882003277 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 227882003278 active site 227882003279 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 227882003280 catalytic triad [active] 227882003281 dimer interface [polypeptide binding]; other site 227882003282 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 227882003283 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 227882003284 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 227882003285 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 227882003286 G1 box; other site 227882003287 GTP/Mg2+ binding site [chemical binding]; other site 227882003288 G2 box; other site 227882003289 Switch I region; other site 227882003290 G3 box; other site 227882003291 Switch II region; other site 227882003292 G5 box; other site 227882003293 Protein of unknown function (DUF742); Region: DUF742; pfam05331 227882003294 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 227882003295 Nitrate and nitrite sensing; Region: NIT; pfam08376 227882003296 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 227882003297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882003298 ATP binding site [chemical binding]; other site 227882003299 Mg2+ binding site [ion binding]; other site 227882003300 G-X-G motif; other site 227882003301 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 227882003302 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 227882003303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882003304 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882003305 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882003306 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 227882003307 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These...; Region: Delta6-FADS-like; cd03506 227882003308 Fatty acid desaturase; Region: FA_desaturase; pfam00487 227882003309 putative di-iron ligands [ion binding]; other site 227882003310 SNF2 Helicase protein; Region: DUF3670; pfam12419 227882003311 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 227882003312 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 227882003313 ATP binding site [chemical binding]; other site 227882003314 putative Mg++ binding site [ion binding]; other site 227882003315 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 227882003316 nucleotide binding region [chemical binding]; other site 227882003317 ATP-binding site [chemical binding]; other site 227882003318 Uncharacterized conserved protein [Function unknown]; Region: COG4279 227882003319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882003320 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 227882003321 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 227882003322 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 227882003323 active site 227882003324 catalytic tetrad [active] 227882003325 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 227882003326 Domain of unknown function (DUF309); Region: DUF309; cl00667 227882003327 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 227882003328 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 227882003329 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 227882003330 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 227882003331 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882003332 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882003333 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 227882003334 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 227882003335 dimer interface [polypeptide binding]; other site 227882003336 active site 227882003337 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 227882003338 Ferritin-like domain; Region: Ferritin; pfam00210 227882003339 dimerization interface [polypeptide binding]; other site 227882003340 DPS ferroxidase diiron center [ion binding]; other site 227882003341 ion pore; other site 227882003342 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 227882003343 minor groove reading motif; other site 227882003344 helix-hairpin-helix signature motif; other site 227882003345 active site 227882003346 Domain of unknown function DUF20; Region: UPF0118; cl00465 227882003347 Transcriptional regulators [Transcription]; Region: MarR; COG1846 227882003348 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882003349 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 227882003350 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 227882003351 Cytochrome P450; Region: p450; cl12078 227882003352 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 227882003353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882003354 active site 227882003355 phosphorylation site [posttranslational modification] 227882003356 intermolecular recognition site; other site 227882003357 dimerization interface [polypeptide binding]; other site 227882003358 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882003359 DNA binding site [nucleotide binding] 227882003360 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 227882003361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882003362 NAD(P) binding site [chemical binding]; other site 227882003363 active site 227882003364 benzoate transport; Region: 2A0115; TIGR00895 227882003365 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882003366 putative substrate translocation pore; other site 227882003367 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 227882003368 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 227882003369 tetramer interface [polypeptide binding]; other site 227882003370 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 227882003371 tetramer interface [polypeptide binding]; other site 227882003372 active site 227882003373 metal binding site [ion binding]; metal-binding site 227882003374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 227882003375 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 227882003376 hypothetical protein; Validated; Region: PRK06201 227882003377 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 227882003378 Transcriptional regulators [Transcription]; Region: GntR; COG1802 227882003379 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882003380 DNA-binding site [nucleotide binding]; DNA binding site 227882003381 FCD domain; Region: FCD; cl11656 227882003382 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882003383 choline dehydrogenase; Validated; Region: PRK02106 227882003384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882003385 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 227882003386 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 227882003387 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 227882003388 tetramerization interface [polypeptide binding]; other site 227882003389 NAD(P) binding site [chemical binding]; other site 227882003390 catalytic residues [active] 227882003391 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cl01629 227882003392 TPP-binding site [chemical binding]; other site 227882003393 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 227882003394 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 227882003395 PYR/PP interface [polypeptide binding]; other site 227882003396 dimer interface [polypeptide binding]; other site 227882003397 TPP binding site [chemical binding]; other site 227882003398 Protein of unknown function (DUF419); Region: DUF419; cl15265 227882003399 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 227882003400 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882003401 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 227882003402 putative dimerization interface [polypeptide binding]; other site 227882003403 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 227882003404 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 227882003405 substrate-cofactor binding pocket; other site 227882003406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882003407 catalytic residue [active] 227882003408 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 227882003409 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 227882003410 NAD(P) binding site [chemical binding]; other site 227882003411 GAF domain; Region: GAF; cl00853 227882003412 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 227882003413 Protein of unknown function (DUF742); Region: DUF742; pfam05331 227882003414 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 227882003415 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 227882003416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882003417 ATP binding site [chemical binding]; other site 227882003418 Mg2+ binding site [ion binding]; other site 227882003419 G-X-G motif; other site 227882003420 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 227882003421 Uncharacterized conserved protein [Function unknown]; Region: COG2128 227882003422 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 227882003423 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 227882003424 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 227882003425 NAD(P) binding site [chemical binding]; other site 227882003426 TetR family transcriptional regulator; Provisional; Region: PRK14996 227882003427 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 227882003428 active site 227882003429 catalytic triad [active] 227882003430 oxyanion hole [active] 227882003431 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 227882003432 Peptidase family M23; Region: Peptidase_M23; pfam01551 227882003433 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 227882003434 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 227882003435 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 227882003436 sequence-specific DNA binding site [nucleotide binding]; other site 227882003437 salt bridge; other site 227882003438 Cupin domain; Region: Cupin_2; cl09118 227882003439 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 227882003440 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 227882003441 inhibitor-cofactor binding pocket; inhibition site 227882003442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882003443 catalytic residue [active] 227882003444 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12571 227882003445 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 227882003446 TPP-binding site; other site 227882003447 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 227882003448 PYR/PP interface [polypeptide binding]; other site 227882003449 dimer interface [polypeptide binding]; other site 227882003450 TPP binding site [chemical binding]; other site 227882003451 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 227882003452 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 227882003453 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 227882003454 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 227882003455 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 227882003456 FeS/SAM binding site; other site 227882003457 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 227882003458 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 227882003459 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 227882003460 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 227882003461 Active site cavity [active] 227882003462 catalytic acid [active] 227882003463 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 227882003464 substrate binding pocket [chemical binding]; other site 227882003465 chain length determination region; other site 227882003466 substrate-Mg2+ binding site; other site 227882003467 catalytic residues [active] 227882003468 aspartate-rich region 1; other site 227882003469 active site lid residues [active] 227882003470 aspartate-rich region 2; other site 227882003471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882003472 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 227882003473 active site lid residues [active] 227882003474 substrate binding pocket [chemical binding]; other site 227882003475 catalytic residues [active] 227882003476 substrate-Mg2+ binding site; other site 227882003477 aspartate-rich region 1; other site 227882003478 aspartate-rich region 2; other site 227882003479 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 227882003480 active site lid residues [active] 227882003481 substrate binding pocket [chemical binding]; other site 227882003482 catalytic residues [active] 227882003483 substrate-Mg2+ binding site; other site 227882003484 aspartate-rich region 1; other site 227882003485 aspartate-rich region 2; other site 227882003486 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 227882003487 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 227882003488 Walker A/P-loop; other site 227882003489 ATP binding site [chemical binding]; other site 227882003490 Q-loop/lid; other site 227882003491 ABC transporter signature motif; other site 227882003492 Walker B; other site 227882003493 D-loop; other site 227882003494 H-loop/switch region; other site 227882003495 ABC-2 type transporter; Region: ABC2_membrane; cl11417 227882003496 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 227882003497 active site 227882003498 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 227882003499 Glycerol-1-phosphate dehydrogenase-like; Region: G1PDH-like; cd08174 227882003500 active site 227882003501 metal binding site [ion binding]; metal-binding site 227882003502 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 227882003503 active site 227882003504 metal binding site [ion binding]; metal-binding site 227882003505 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 227882003506 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882003507 NAD(P) binding site [chemical binding]; other site 227882003508 active site 227882003509 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 227882003510 nudix motif; other site 227882003511 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882003512 ATP binding site [chemical binding]; other site 227882003513 Mg2+ binding site [ion binding]; other site 227882003514 enoyl-CoA hydratase; Provisional; Region: PRK06127 227882003515 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 227882003516 substrate binding site [chemical binding]; other site 227882003517 oxyanion hole (OAH) forming residues; other site 227882003518 trimer interface [polypeptide binding]; other site 227882003519 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 227882003520 conserved cys residue [active] 227882003521 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 227882003522 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 227882003523 conserved cys residue [active] 227882003524 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882003525 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 227882003526 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 227882003527 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 227882003528 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 227882003529 RNA binding site [nucleotide binding]; other site 227882003530 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 227882003531 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882003532 Walker A/P-loop; other site 227882003533 ATP binding site [chemical binding]; other site 227882003534 Q-loop/lid; other site 227882003535 ABC transporter signature motif; other site 227882003536 Walker B; other site 227882003537 D-loop; other site 227882003538 H-loop/switch region; other site 227882003539 ABC transporter; Region: ABC_tran_2; pfam12848 227882003540 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 227882003541 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 227882003542 Peptidase M14-like domain of a functionally uncharacterized subgroup of the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains...; Region: Peptidase_M14-like_1_6; cd06243 227882003543 putative active site [active] 227882003544 Zn-binding site [ion binding]; other site 227882003545 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 227882003546 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 227882003547 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 227882003548 Zn binding site [ion binding]; other site 227882003549 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 227882003550 ADP-ribose binding site [chemical binding]; other site 227882003551 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882003552 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 227882003553 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 227882003554 DNA binding residues [nucleotide binding] 227882003555 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 227882003556 classical (c) SDRs; Region: SDR_c; cd05233 227882003557 NAD(P) binding site [chemical binding]; other site 227882003558 active site 227882003559 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 227882003560 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 227882003561 substrate binding site [chemical binding]; other site 227882003562 oxyanion hole (OAH) forming residues; other site 227882003563 trimer interface [polypeptide binding]; other site 227882003564 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 227882003565 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 227882003566 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 227882003567 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 227882003568 dimer interface [polypeptide binding]; other site 227882003569 active site 227882003570 CoA-transferase family III; Region: CoA_transf_3; cl00778 227882003571 Uncharacterized conserved protein [Function unknown]; Region: COG3268 227882003572 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882003573 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 227882003574 Active_site [active] 227882003575 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 227882003576 Ycf48-like protein; Provisional; Region: PRK13684 227882003577 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 227882003578 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 227882003579 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882003580 Walker A/P-loop; other site 227882003581 ATP binding site [chemical binding]; other site 227882003582 Q-loop/lid; other site 227882003583 ABC transporter signature motif; other site 227882003584 Walker B; other site 227882003585 D-loop; other site 227882003586 H-loop/switch region; other site 227882003587 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 227882003588 Amidinotransferase; Region: Amidinotransf; cl12043 227882003589 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 227882003590 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 227882003591 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 227882003592 homodimer interface [polypeptide binding]; other site 227882003593 putative substrate binding pocket [chemical binding]; other site 227882003594 diiron center [ion binding]; other site 227882003595 Transcription factor WhiB; Region: Whib; pfam02467 227882003596 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 227882003597 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 227882003598 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882003599 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882003600 DNA binding site [nucleotide binding] 227882003601 domain linker motif; other site 227882003602 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 227882003603 putative dimerization interface [polypeptide binding]; other site 227882003604 putative ligand binding site [chemical binding]; other site 227882003605 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 227882003606 nucleotide binding site [chemical binding]; other site 227882003607 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 227882003608 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 227882003609 active site 227882003610 DNA binding site [nucleotide binding] 227882003611 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 227882003612 DNA binding site [nucleotide binding] 227882003613 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 227882003614 Transcriptional regulators [Transcription]; Region: MarR; COG1846 227882003615 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882003616 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 227882003617 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 227882003618 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 227882003619 active site 227882003620 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 227882003621 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl01383 227882003622 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 227882003623 Active site [active] 227882003624 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 227882003625 heterodimer interface [polypeptide binding]; other site 227882003626 active site 227882003627 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 227882003628 prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597 227882003629 tetramer interface [polypeptide binding]; other site 227882003630 active site 227882003631 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 227882003632 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882003633 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882003634 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 227882003635 Predicted ATPase [General function prediction only]; Region: COG3899 227882003636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882003637 metabolite-proton symporter; Region: 2A0106; TIGR00883 227882003638 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 227882003639 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 227882003640 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882003641 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882003642 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 227882003643 active site 227882003644 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 227882003645 Scramblase; Region: Scramblase; cl02043 227882003646 Pseudomonas-type; Region: PC_PLC; TIGR03396 227882003647 Sulfatase; Region: Sulfatase; cl10460 227882003648 Domain of unknown function (DUF756); Region: DUF756; pfam05506 227882003649 Domain of unknown function (DUF756); Region: DUF756; pfam05506 227882003650 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 227882003651 dimerization interface [polypeptide binding]; other site 227882003652 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 227882003653 Moco binding site; other site 227882003654 metal coordination site [ion binding]; other site 227882003655 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 227882003656 DNA binding residues [nucleotide binding] 227882003657 TOBE domain; Region: TOBE_2; cl01440 227882003658 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882003659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882003660 dimer interface [polypeptide binding]; other site 227882003661 conserved gate region; other site 227882003662 putative PBP binding loops; other site 227882003663 ABC-ATPase subunit interface; other site 227882003664 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 227882003665 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882003666 Walker A/P-loop; other site 227882003667 ATP binding site [chemical binding]; other site 227882003668 Q-loop/lid; other site 227882003669 ABC transporter signature motif; other site 227882003670 Walker B; other site 227882003671 D-loop; other site 227882003672 H-loop/switch region; other site 227882003673 TOBE domain; Region: TOBE_2; cl01440 227882003674 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 227882003675 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 227882003676 MOSC domain; Region: MOSC; pfam03473 227882003677 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 227882003678 putative metal binding site [ion binding]; other site 227882003679 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 227882003680 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 227882003681 sugar binding site [chemical binding]; other site 227882003682 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 227882003683 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 227882003684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882003685 dimer interface [polypeptide binding]; other site 227882003686 conserved gate region; other site 227882003687 putative PBP binding loops; other site 227882003688 ABC-ATPase subunit interface; other site 227882003689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882003690 dimer interface [polypeptide binding]; other site 227882003691 conserved gate region; other site 227882003692 putative PBP binding loops; other site 227882003693 ABC-ATPase subunit interface; other site 227882003694 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882003695 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882003696 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882003697 DNA binding site [nucleotide binding] 227882003698 domain linker motif; other site 227882003699 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 227882003700 putative dimerization interface [polypeptide binding]; other site 227882003701 putative ligand binding site [chemical binding]; other site 227882003702 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882003703 DNA-binding site [nucleotide binding]; DNA binding site 227882003704 FCD domain; Region: FCD; cl11656 227882003705 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 227882003706 Proline racemase; Region: Pro_racemase; pfam05544 227882003707 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 227882003708 inhibitor site; inhibition site 227882003709 active site 227882003710 dimer interface [polypeptide binding]; other site 227882003711 catalytic residue [active] 227882003712 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 227882003713 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 227882003714 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 227882003715 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 227882003716 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 227882003717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882003718 dimer interface [polypeptide binding]; other site 227882003719 conserved gate region; other site 227882003720 putative PBP binding loops; other site 227882003721 ABC-ATPase subunit interface; other site 227882003722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882003723 dimer interface [polypeptide binding]; other site 227882003724 conserved gate region; other site 227882003725 putative PBP binding loops; other site 227882003726 ABC-ATPase subunit interface; other site 227882003727 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 227882003728 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882003729 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 227882003730 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882003731 Walker A/P-loop; other site 227882003732 ATP binding site [chemical binding]; other site 227882003733 Q-loop/lid; other site 227882003734 ABC transporter signature motif; other site 227882003735 Walker B; other site 227882003736 D-loop; other site 227882003737 H-loop/switch region; other site 227882003738 TOBE domain; Region: TOBE_2; cl01440 227882003739 Transcriptional regulators [Transcription]; Region: FadR; COG2186 227882003740 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882003741 DNA-binding site [nucleotide binding]; DNA binding site 227882003742 FCD domain; Region: FCD; cl11656 227882003743 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 227882003744 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882003745 hypothetical protein; Provisional; Region: PRK06185 227882003746 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882003747 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882003748 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882003749 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 227882003750 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 227882003751 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 227882003752 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 227882003753 active site 227882003754 metal binding site [ion binding]; metal-binding site 227882003755 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 227882003756 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 227882003757 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 227882003758 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 227882003759 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 227882003760 active site 227882003761 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 227882003762 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 227882003763 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 227882003764 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 227882003765 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 227882003766 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 227882003767 NAD binding site [chemical binding]; other site 227882003768 sugar binding site [chemical binding]; other site 227882003769 divalent metal binding site [ion binding]; other site 227882003770 tetramer (dimer of dimers) interface [polypeptide binding]; other site 227882003771 dimer interface [polypeptide binding]; other site 227882003772 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 227882003773 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882003774 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 227882003775 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 227882003776 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 227882003777 substrate binding site [chemical binding]; other site 227882003778 ATP binding site [chemical binding]; other site 227882003779 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 227882003780 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882003781 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 227882003782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882003783 dimer interface [polypeptide binding]; other site 227882003784 conserved gate region; other site 227882003785 putative PBP binding loops; other site 227882003786 ABC-ATPase subunit interface; other site 227882003787 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 227882003788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882003789 dimer interface [polypeptide binding]; other site 227882003790 conserved gate region; other site 227882003791 putative PBP binding loops; other site 227882003792 ABC-ATPase subunit interface; other site 227882003793 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 227882003794 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 227882003795 domain; Region: Glyco_hydro_2; pfam00703 227882003796 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl14895 227882003797 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 227882003798 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 227882003799 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 227882003800 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 227882003801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 227882003802 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 227882003803 active site 227882003804 catalytic residues [active] 227882003805 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 227882003806 Cupin domain; Region: Cupin_2; cl09118 227882003807 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 227882003808 transketolase; Reviewed; Region: PRK05899 227882003809 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 227882003810 TPP-binding site [chemical binding]; other site 227882003811 dimer interface [polypeptide binding]; other site 227882003812 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 227882003813 PYR/PP interface [polypeptide binding]; other site 227882003814 dimer interface [polypeptide binding]; other site 227882003815 TPP binding site [chemical binding]; other site 227882003816 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 227882003817 putative active site [active] 227882003818 transaldolase; Provisional; Region: PRK03903 227882003819 catalytic residue [active] 227882003820 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 227882003821 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 227882003822 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 227882003823 opcA protein; Region: OpcA; TIGR00534 227882003824 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 227882003825 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 227882003826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882003827 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 227882003828 active site 227882003829 dimer interface [polypeptide binding]; other site 227882003830 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 227882003831 dimer interface [polypeptide binding]; other site 227882003832 active site 227882003833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882003834 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 227882003835 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 227882003836 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 227882003837 catalytic core [active] 227882003838 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 227882003839 putative heme binding pocket [chemical binding]; other site 227882003840 Animal heme oxidases similar to plant pathogen-inducible oxygenases; Region: PIOX_like; cd09818 227882003841 putative heme binding site [chemical binding]; other site 227882003842 putative active site [active] 227882003843 putative substrate binding site [chemical binding]; other site 227882003844 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 227882003845 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 227882003846 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 227882003847 active site 227882003848 metal binding site [ion binding]; metal-binding site 227882003849 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 227882003850 active site 227882003851 Fe binding site [ion binding]; other site 227882003852 shikimate 5-dehydrogenase; Reviewed; Region: PRK12549 227882003853 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 227882003854 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 227882003855 shikimate binding site; other site 227882003856 NAD(P) binding site [chemical binding]; other site 227882003857 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 227882003858 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882003859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882003860 metabolite-proton symporter; Region: 2A0106; TIGR00883 227882003861 putative substrate translocation pore; other site 227882003862 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 227882003863 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882003864 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882003865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882003866 putative substrate translocation pore; other site 227882003867 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 227882003868 Beta-lactamase; Region: Beta-lactamase; cl01009 227882003869 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 227882003870 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 227882003871 DNA binding residues [nucleotide binding] 227882003872 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 227882003873 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 227882003874 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882003875 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 227882003876 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 227882003877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882003878 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 227882003879 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 227882003880 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 227882003881 dimerization interface [polypeptide binding]; other site 227882003882 active site 227882003883 Creatinine amidohydrolase; Region: Creatininase; cl00618 227882003884 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 227882003885 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882003886 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 227882003887 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 227882003888 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 227882003889 putative NAD(P) binding site [chemical binding]; other site 227882003890 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 227882003891 elongation factor G; Reviewed; Region: PRK13351 227882003892 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 227882003893 G1 box; other site 227882003894 putative GEF interaction site [polypeptide binding]; other site 227882003895 GTP/Mg2+ binding site [chemical binding]; other site 227882003896 Switch I region; other site 227882003897 G2 box; other site 227882003898 G3 box; other site 227882003899 Switch II region; other site 227882003900 G4 box; other site 227882003901 G5 box; other site 227882003902 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 227882003903 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 227882003904 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 227882003905 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 227882003906 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 227882003907 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 227882003908 active site 227882003909 catalytic residues [active] 227882003910 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 227882003911 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 227882003912 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 227882003913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882003914 dimer interface [polypeptide binding]; other site 227882003915 conserved gate region; other site 227882003916 putative PBP binding loops; other site 227882003917 ABC-ATPase subunit interface; other site 227882003918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882003919 dimer interface [polypeptide binding]; other site 227882003920 conserved gate region; other site 227882003921 putative PBP binding loops; other site 227882003922 ABC-ATPase subunit interface; other site 227882003923 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882003924 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882003925 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 227882003926 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882003927 NlpC/P60 family; Region: NLPC_P60; cl11438 227882003928 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 227882003929 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882003930 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 227882003931 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882003932 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 227882003933 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882003934 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 227882003935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882003936 Walker A motif; other site 227882003937 ATP binding site [chemical binding]; other site 227882003938 Walker B motif; other site 227882003939 Uncharacterized conserved protein [Function unknown]; Region: COG3410 227882003940 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882003941 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 227882003942 Walker A motif; other site 227882003943 ATP binding site [chemical binding]; other site 227882003944 Walker B motif; other site 227882003945 Uncharacterized conserved protein [Function unknown]; Region: COG3410 227882003946 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 227882003947 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 227882003948 NAD(P) binding site [chemical binding]; other site 227882003949 catalytic residues [active] 227882003950 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 227882003951 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882003952 CoA-ligase; Region: Ligase_CoA; pfam00549 227882003953 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 227882003954 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 227882003955 CoA-ligase; Region: Ligase_CoA; pfam00549 227882003956 hypothetical protein; Provisional; Region: PRK05858 227882003957 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 227882003958 PYR/PP interface [polypeptide binding]; other site 227882003959 dimer interface [polypeptide binding]; other site 227882003960 TPP binding site [chemical binding]; other site 227882003961 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 227882003962 TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL cleaves the acyloin linkage of benzoin producing 2 molecules...; Region: TPP_BZL_OCoD_HPCL; cd02004 227882003963 TPP-binding site; other site 227882003964 dimer interface [polypeptide binding]; other site 227882003965 CoA-transferase family III; Region: CoA_transf_3; cl00778 227882003966 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 227882003967 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 227882003968 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882003969 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 227882003970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882003971 putative substrate translocation pore; other site 227882003972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882003973 Major Facilitator Superfamily; Region: MFS_1; pfam07690 227882003974 putative substrate translocation pore; other site 227882003975 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 227882003976 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 227882003977 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 227882003978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882003979 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 227882003980 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 227882003981 putative ligand binding site [chemical binding]; other site 227882003982 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 227882003983 TM-ABC transporter signature motif; other site 227882003984 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 227882003985 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 227882003986 Walker A/P-loop; other site 227882003987 ATP binding site [chemical binding]; other site 227882003988 Q-loop/lid; other site 227882003989 ABC transporter signature motif; other site 227882003990 Walker B; other site 227882003991 D-loop; other site 227882003992 H-loop/switch region; other site 227882003993 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 227882003994 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 227882003995 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 227882003996 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882003997 Transcriptional regulators [Transcription]; Region: GntR; COG1802 227882003998 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882003999 DNA-binding site [nucleotide binding]; DNA binding site 227882004000 FCD domain; Region: FCD; cl11656 227882004001 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 227882004002 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 227882004003 dimer interface [polypeptide binding]; other site 227882004004 active site 227882004005 CoA binding pocket [chemical binding]; other site 227882004006 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 227882004007 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882004008 putative substrate translocation pore; other site 227882004009 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 227882004010 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882004011 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 227882004012 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 227882004013 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 227882004014 molybdopterin cofactor binding site; other site 227882004015 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of...; Region: MopB_CT_Fdh-Nap-like; cd00508 227882004016 molybdopterin cofactor binding site; other site 227882004017 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 227882004018 putative dimer interface [polypeptide binding]; other site 227882004019 [2Fe-2S] cluster binding site [ion binding]; other site 227882004020 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 227882004021 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 227882004022 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 227882004023 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 227882004024 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 227882004025 catalytic loop [active] 227882004026 iron binding site [ion binding]; other site 227882004027 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 227882004028 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 227882004029 Isochorismatase family; Region: Isochorismatase; pfam00857 227882004030 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 227882004031 catalytic triad [active] 227882004032 conserved cis-peptide bond; other site 227882004033 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882004034 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 227882004035 NAD(P) binding site [chemical binding]; other site 227882004036 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 227882004037 catalytic site [active] 227882004038 Asp-box motif; other site 227882004039 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 227882004040 Membrane transport protein; Region: Mem_trans; cl09117 227882004041 Transcriptional regulator [Transcription]; Region: LysR; COG0583 227882004042 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882004043 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882004044 dimerization interface [polypeptide binding]; other site 227882004045 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 227882004046 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 227882004047 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882004048 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 227882004049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882004050 putative substrate translocation pore; other site 227882004051 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 227882004052 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882004053 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882004054 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 227882004055 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 227882004056 active site 227882004057 catalytic tetrad [active] 227882004058 Fungal chitosanase; Region: Chitosanase; pfam07335 227882004059 short chain dehydrogenase; Provisional; Region: PRK08219 227882004060 classical (c) SDRs; Region: SDR_c; cd05233 227882004061 NAD(P) binding site [chemical binding]; other site 227882004062 active site 227882004063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882004064 Cellulose binding domain; Region: CBM_2; cl02709 227882004065 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 227882004066 Cellulose binding domain; Region: CBM_2; cl02709 227882004067 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl14895 227882004068 Cellulose binding domain; Region: CBM_2; cl02709 227882004069 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 227882004070 VPS10 domain; Region: VPS10; smart00602 227882004071 Cellulose binding domain; Region: CBM_2; cl02709 227882004072 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 227882004073 aromatic arch; other site 227882004074 DCoH dimer interaction site [polypeptide binding]; other site 227882004075 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 227882004076 DCoH tetramer interaction site [polypeptide binding]; other site 227882004077 substrate binding site [chemical binding]; other site 227882004078 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 227882004079 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 227882004080 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 227882004081 non-specific DNA binding site [nucleotide binding]; other site 227882004082 salt bridge; other site 227882004083 sequence-specific DNA binding site [nucleotide binding]; other site 227882004084 OsmC-like protein; Region: OsmC; cl00767 227882004085 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 227882004086 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: vWA_subgroup; cd01465 227882004087 metal ion-dependent adhesion site (MIDAS); other site 227882004088 Sulfatase; Region: Sulfatase; cl10460 227882004089 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 227882004090 catalytic residues [active] 227882004091 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 227882004092 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 227882004093 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 227882004094 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 227882004095 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882004096 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 227882004097 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882004098 DNA binding residues [nucleotide binding] 227882004099 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 227882004100 FOG: CBS domain [General function prediction only]; Region: COG0517 227882004101 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_9; cd04622 227882004102 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 227882004103 proposed catalytic triad [active] 227882004104 conserved cys residue [active] 227882004105 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882004106 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 227882004107 Walker A/P-loop; other site 227882004108 ATP binding site [chemical binding]; other site 227882004109 ABC transporter signature motif; other site 227882004110 Walker B; other site 227882004111 D-loop; other site 227882004112 H-loop/switch region; other site 227882004113 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 227882004114 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 227882004115 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 227882004116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882004117 S-adenosylmethionine binding site [chemical binding]; other site 227882004118 Gas vesicle protein K; Region: GvpK; pfam05121 227882004119 Gas vesicle protein; Region: Gas_vesicle; cl02954 227882004120 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 227882004121 Gas vesicle protein; Region: Gas_vesicle; cl02954 227882004122 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 227882004123 putative hydrophobic ligand binding site [chemical binding]; other site 227882004124 Gas vesicle protein G; Region: GvpG; pfam05120 227882004125 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 227882004126 Gas vesicle protein; Region: Gas_vesicle; cl02954 227882004127 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 227882004128 transketolase; Reviewed; Region: PRK05899 227882004129 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 227882004130 TPP-binding site [chemical binding]; other site 227882004131 dimer interface [polypeptide binding]; other site 227882004132 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 227882004133 PYR/PP interface [polypeptide binding]; other site 227882004134 dimer interface [polypeptide binding]; other site 227882004135 TPP binding site [chemical binding]; other site 227882004136 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 227882004137 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 227882004138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882004139 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 227882004140 Arginase family; Region: Arginase; cl00306 227882004141 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 227882004142 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882004143 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 227882004144 dimer interface [polypeptide binding]; other site 227882004145 catalytic triad [active] 227882004146 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 227882004147 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882004148 hypothetical protein; Provisional; Region: PRK07906 227882004149 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 227882004150 putative metal binding site [ion binding]; other site 227882004151 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 227882004152 SxDxEG motif; other site 227882004153 active site 227882004154 metal binding site [ion binding]; metal-binding site 227882004155 homopentamer interface [polypeptide binding]; other site 227882004156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882004157 S-adenosylmethionine binding site [chemical binding]; other site 227882004158 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 227882004159 GAF domain; Region: GAF; cl00853 227882004160 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882004161 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882004162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882004163 Major Facilitator Superfamily; Region: MFS_1; pfam07690 227882004164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882004165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882004166 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 227882004167 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 227882004168 hydrophobic ligand binding site; other site 227882004169 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 227882004170 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 227882004171 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882004172 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882004173 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 227882004174 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 227882004175 Coenzyme A binding pocket [chemical binding]; other site 227882004176 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 227882004177 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 227882004178 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 227882004179 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 227882004180 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 227882004181 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 227882004182 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 227882004183 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882004184 crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246 227882004185 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 227882004186 putative NAD(P) binding site [chemical binding]; other site 227882004187 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of methylmalonyl-; Region: MM_CoA_mutase; cl00817 227882004188 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen...; Region: MM_CoA_mut_B12_BD; cd02071 227882004189 B12 binding site [chemical binding]; other site 227882004190 cobalt ligand [ion binding]; other site 227882004191 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 227882004192 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 227882004193 putative active site [active] 227882004194 putative catalytic site [active] 227882004195 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 227882004196 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882004197 active site 227882004198 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 227882004199 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 227882004200 Glycerate kinase family; Region: Gly_kinase; cl00841 227882004201 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 227882004202 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 227882004203 nudix motif; other site 227882004204 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882004205 glucose-1-dehydrogenase; Provisional; Region: PRK08936 227882004206 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 227882004207 NAD binding site [chemical binding]; other site 227882004208 homodimer interface [polypeptide binding]; other site 227882004209 active site 227882004210 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 227882004211 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 227882004212 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 227882004213 Domain of unknown function (DUF389); Region: DUF389; cl00781 227882004214 Putative cyclase; Region: Cyclase; cl00814 227882004215 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 227882004216 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 227882004217 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 227882004218 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 227882004219 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 227882004220 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 227882004221 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 227882004222 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 227882004223 DNA binding site [nucleotide binding] 227882004224 active site 227882004225 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 227882004226 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 227882004227 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882004228 AlkA N-terminal domain; Region: AlkA_N; cl05528 227882004229 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 227882004230 minor groove reading motif; other site 227882004231 helix-hairpin-helix signature motif; other site 227882004232 active site 227882004233 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 227882004234 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 227882004235 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 227882004236 [2Fe-2S] cluster binding site [ion binding]; other site 227882004237 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 227882004238 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882004239 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 227882004240 active site 227882004241 putative lithium-binding site [ion binding]; other site 227882004242 substrate binding site [chemical binding]; other site 227882004243 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 227882004244 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 227882004245 formate dehydrogenase; Provisional; Region: PRK07574 227882004246 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882004247 CrcB-like protein; Region: CRCB; cl09114 227882004248 CrcB-like protein; Region: CRCB; cl09114 227882004249 AmiS/UreI family transporter; Region: AmiS_UreI; pfam02293 227882004250 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 227882004251 Sodium:solute symporter family; Region: SSF; cl00456 227882004252 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 227882004253 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 227882004254 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882004255 phenylhydantoinase; Validated; Region: PRK08323 227882004256 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like...; Region: D-HYD; cd01314 227882004257 tetramer interface [polypeptide binding]; other site 227882004258 active site 227882004259 N-carbamolyputrescine amidase; Region: PLN02747 227882004260 mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases); Region: ML_beta-AS_like; cd07568 227882004261 putative active site [active] 227882004262 catalytic triad [active] 227882004263 multimer interface [polypeptide binding]; other site 227882004264 dimer interface [polypeptide binding]; other site 227882004265 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 227882004266 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 227882004267 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 227882004268 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 227882004269 inhibitor-cofactor binding pocket; inhibition site 227882004270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882004271 catalytic residue [active] 227882004272 N-carbamolyputrescine amidase; Region: PLN02747 227882004273 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 227882004274 active site 227882004275 catalytic triad [active] 227882004276 dimer interface [polypeptide binding]; other site 227882004277 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882004278 methionine aminopeptidase; Reviewed; Region: PRK07281 227882004279 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 227882004280 active site 227882004281 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 227882004282 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 227882004283 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 227882004284 Chlorophyllase; Region: Chlorophyllase; cl15281 227882004285 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 227882004286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882004287 dimer interface [polypeptide binding]; other site 227882004288 conserved gate region; other site 227882004289 putative PBP binding loops; other site 227882004290 ABC-ATPase subunit interface; other site 227882004291 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 227882004292 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882004293 dimer interface [polypeptide binding]; other site 227882004294 conserved gate region; other site 227882004295 putative PBP binding loops; other site 227882004296 ABC-ATPase subunit interface; other site 227882004297 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 227882004298 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 227882004299 substrate binding pocket [chemical binding]; other site 227882004300 membrane-bound complex binding site; other site 227882004301 hinge residues; other site 227882004302 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 227882004303 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 227882004304 Walker A/P-loop; other site 227882004305 ATP binding site [chemical binding]; other site 227882004306 Q-loop/lid; other site 227882004307 ABC transporter signature motif; other site 227882004308 Walker B; other site 227882004309 D-loop; other site 227882004310 H-loop/switch region; other site 227882004311 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and...; Region: XynE_like; cd01830 227882004312 active site 227882004313 catalytic triad [active] 227882004314 oxyanion hole [active] 227882004315 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 227882004316 putative phosphate binding site [ion binding]; other site 227882004317 putative catalytic site [active] 227882004318 active site 227882004319 metal binding site A [ion binding]; metal-binding site 227882004320 DNA binding site [nucleotide binding] 227882004321 putative AP binding site [nucleotide binding]; other site 227882004322 putative metal binding site B [ion binding]; other site 227882004323 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 227882004324 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 227882004325 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882004326 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 227882004327 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 227882004328 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 227882004329 classical (c) SDR, subgroup 2; Region: SDR_c2; cd05370 227882004330 putative NAD(P) binding site [chemical binding]; other site 227882004331 active site 227882004332 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882004333 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 227882004334 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882004335 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 227882004336 active site 227882004337 Uncharacterized conserved protein [Function unknown]; Region: COG4279 227882004338 SNF2 Helicase protein; Region: DUF3670; pfam12419 227882004339 Probable chromatin-remodeling complex ATPase chain; Provisional; Region: PLN03142 227882004340 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 227882004341 ATP binding site [chemical binding]; other site 227882004342 putative Mg++ binding site [ion binding]; other site 227882004343 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 227882004344 nucleotide binding region [chemical binding]; other site 227882004345 ATP-binding site [chemical binding]; other site 227882004346 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 227882004347 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882004348 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 227882004349 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882004350 Walker A/P-loop; other site 227882004351 ATP binding site [chemical binding]; other site 227882004352 Q-loop/lid; other site 227882004353 ABC transporter signature motif; other site 227882004354 Walker B; other site 227882004355 D-loop; other site 227882004356 H-loop/switch region; other site 227882004357 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 227882004358 TM-ABC transporter signature motif; other site 227882004359 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 227882004360 putative ligand binding site [chemical binding]; other site 227882004361 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 227882004362 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882004363 DNA-binding site [nucleotide binding]; DNA binding site 227882004364 UTRA domain; Region: UTRA; cl01230 227882004365 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 227882004366 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882004367 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 227882004368 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 227882004369 CoenzymeA binding site [chemical binding]; other site 227882004370 subunit interaction site [polypeptide binding]; other site 227882004371 PHB binding site; other site 227882004372 Cytochrome P450; Region: p450; cl12078 227882004373 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882004374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882004375 active site 227882004376 phosphorylation site [posttranslational modification] 227882004377 intermolecular recognition site; other site 227882004378 dimerization interface [polypeptide binding]; other site 227882004379 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882004380 DNA binding residues [nucleotide binding] 227882004381 dimerization interface [polypeptide binding]; other site 227882004382 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 227882004383 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 227882004384 active site 227882004385 catalytic tetrad [active] 227882004386 Histidine kinase; Region: HisKA_3; pfam07730 227882004387 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882004388 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a...; Region: RNase_Sa; cd00607 227882004389 active site 227882004390 barstar interaction site; other site 227882004391 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 227882004392 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 227882004393 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 227882004394 allantoicase; Provisional; Region: PRK13257 227882004395 Allantoicase repeat; Region: Allantoicase; pfam03561 227882004396 Allantoicase repeat; Region: Allantoicase; pfam03561 227882004397 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 227882004398 allantoinase; Region: allantoinase; TIGR03178 227882004399 active site 227882004400 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882004401 Transcriptional regulator [Transcription]; Region: IclR; COG1414 227882004402 Bacterial transcriptional regulator; Region: IclR; pfam01614 227882004403 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 227882004404 metal binding site [ion binding]; metal-binding site 227882004405 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 227882004406 malate synthase A; Region: malate_syn_A; TIGR01344 227882004407 active site 227882004408 Rdx family; Region: Rdx; cl01407 227882004409 IucA / IucC family; Region: IucA_IucC; pfam04183 227882004410 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 227882004411 IucA / IucC family; Region: IucA_IucC; pfam04183 227882004412 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 227882004413 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: vWA_ywmD_type; cd01456 227882004414 metal ion-dependent adhesion site (MIDAS); other site 227882004415 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882004416 tyrosine aminotransferase, eukaryotic; Region: tyr_amTase_E; TIGR01264 227882004417 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 227882004418 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882004419 homodimer interface [polypeptide binding]; other site 227882004420 catalytic residue [active] 227882004421 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 227882004422 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 227882004423 catalytic core [active] 227882004424 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 227882004425 active site 227882004426 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882004427 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 227882004428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882004429 putative substrate translocation pore; other site 227882004430 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 227882004431 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 227882004432 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 227882004433 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin...; Region: chitosanase_glyco_hydro_46; cd00978 227882004434 chitosan binding site [chemical binding]; other site 227882004435 catalytic residues [active] 227882004436 Permease family; Region: Xan_ur_permease; pfam00860 227882004437 Sulfate transporter family; Region: Sulfate_transp; cl00967 227882004438 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 227882004439 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 227882004440 active site 227882004441 putative substrate binding pocket [chemical binding]; other site 227882004442 urate oxidase; Region: urate_oxi; TIGR03383 227882004443 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 227882004444 active site 227882004445 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU)...; Region: TLP_HIUase; cd05822 227882004446 active site 227882004447 homotetramer interface [polypeptide binding]; other site 227882004448 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 227882004449 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 227882004450 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 227882004451 2-hydroxy-3-oxopropionate reductase; Region: tartro_sem_red; TIGR01505 227882004452 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882004453 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 227882004454 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 227882004455 tetramer interface [polypeptide binding]; other site 227882004456 heme binding pocket [chemical binding]; other site 227882004457 NADPH binding site [chemical binding]; other site 227882004458 glyoxylate carboligase; Provisional; Region: PRK11269 227882004459 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 227882004460 PYR/PP interface [polypeptide binding]; other site 227882004461 dimer interface [polypeptide binding]; other site 227882004462 TPP binding site [chemical binding]; other site 227882004463 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 227882004464 TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the condensation of two molecules of glyoxylate to give...; Region: TPP_Gcl; cd02006 227882004465 TPP-binding site [chemical binding]; other site 227882004466 AMP-binding domain protein; Validated; Region: PRK08315 227882004467 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882004468 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 227882004469 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882004470 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882004471 DNA binding residues [nucleotide binding] 227882004472 dimerization interface [polypeptide binding]; other site 227882004473 Predicted ATPase [General function prediction only]; Region: COG3899 227882004474 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882004475 dimerization interface [polypeptide binding]; other site 227882004476 DNA binding residues [nucleotide binding] 227882004477 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cd00190 227882004478 cleavage site 227882004479 active site 227882004480 substrate binding sites [chemical binding]; other site 227882004481 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 227882004482 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 227882004483 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 227882004484 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 227882004485 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 227882004486 heterodimer interface [polypeptide binding]; other site 227882004487 substrate interaction site [chemical binding]; other site 227882004488 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 227882004489 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily...; Region: MM_CoA_mutase_alpha_like; cd03679 227882004490 active site 227882004491 substrate binding site [chemical binding]; other site 227882004492 coenzyme B12 binding site [chemical binding]; other site 227882004493 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen...; Region: MM_CoA_mut_B12_BD; cd02071 227882004494 B12 binding site [chemical binding]; other site 227882004495 cobalt ligand [ion binding]; other site 227882004496 membrane ATPase/protein kinase; Provisional; Region: PRK09435 227882004497 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 227882004498 Walker A; other site 227882004499 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 227882004500 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 227882004501 sequence-specific DNA binding site [nucleotide binding]; other site 227882004502 salt bridge; other site 227882004503 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 227882004504 Domain of unknown function (DUF955); Region: DUF955; cl01076 227882004505 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 227882004506 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 227882004507 tetramer interface [polypeptide binding]; other site 227882004508 active site 227882004509 Mg2+/Mn2+ binding site [ion binding]; other site 227882004510 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 227882004511 malate synthase A; Region: malate_syn_A; TIGR01344 227882004512 active site 227882004513 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 227882004514 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 227882004515 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 227882004516 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 227882004517 N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_N_terminal_like; cd03312 227882004518 THF binding site; other site 227882004519 C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in the production of methionine by...; Region: CIMS_C_terminal_like; cd03311 227882004520 substrate binding site [chemical binding]; other site 227882004521 THF binding site; other site 227882004522 zinc-binding site [ion binding]; other site 227882004523 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 227882004524 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 227882004525 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 227882004526 Beta-lactamase; Region: Beta-lactamase; cl01009 227882004527 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 227882004528 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 227882004529 DNA binding site [nucleotide binding] 227882004530 active site 227882004531 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 227882004532 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 227882004533 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 227882004534 putative NAD(P) binding site [chemical binding]; other site 227882004535 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882004536 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882004537 putative Zn2+ binding site [ion binding]; other site 227882004538 putative DNA binding site [nucleotide binding]; other site 227882004539 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 227882004540 anti sigma factor interaction site; other site 227882004541 regulatory phosphorylation site [posttranslational modification]; other site 227882004542 ANTAR domain; Region: ANTAR; cl04297 227882004543 Histidine kinase; Region: HisKA_3; pfam07730 227882004544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882004545 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 227882004546 Cytochrome P450; Region: p450; cl12078 227882004547 Uncharacterized conserved protein [Function unknown]; Region: COG5634 227882004548 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 227882004549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882004550 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 227882004551 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 227882004552 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 227882004553 Sulfate transporter family; Region: Sulfate_transp; cl00967 227882004554 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 227882004555 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 227882004556 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 227882004557 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 227882004558 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 227882004559 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 227882004560 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 227882004561 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 227882004562 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 227882004563 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 227882004564 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882004565 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 227882004566 DNA-binding site [nucleotide binding]; DNA binding site 227882004567 FCD domain; Region: FCD; cl11656 227882004568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882004569 pyruvate dehydrogenase; Provisional; Region: PRK06546 227882004570 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 227882004571 PYR/PP interface [polypeptide binding]; other site 227882004572 tetramer interface [polypeptide binding]; other site 227882004573 dimer interface [polypeptide binding]; other site 227882004574 TPP binding site [chemical binding]; other site 227882004575 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 227882004576 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX...; Region: TPP_POX; cd02014 227882004577 TPP-binding site [chemical binding]; other site 227882004578 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882004579 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and...; Region: XynE_like; cd01830 227882004580 active site 227882004581 catalytic triad [active] 227882004582 oxyanion hole [active] 227882004583 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 227882004584 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 227882004585 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 227882004586 AlkA N-terminal domain; Region: AlkA_N; cl05528 227882004587 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 227882004588 GTPase RsgA; Reviewed; Region: PRK01889 227882004589 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 227882004590 GTPase/OB domain interface [polypeptide binding]; other site 227882004591 GTPase/Zn-binding domain interface [polypeptide binding]; other site 227882004592 GTP/Mg2+ binding site [chemical binding]; other site 227882004593 G4 box; other site 227882004594 G5 box; other site 227882004595 G1 box; other site 227882004596 Switch I region; other site 227882004597 G2 box; other site 227882004598 G3 box; other site 227882004599 Switch II region; other site 227882004600 Cellulose binding domain; Region: CBM_2; cl02709 227882004601 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 227882004602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882004603 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 227882004604 FAD binding domain; Region: FAD_binding_4; pfam01565 227882004605 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 227882004606 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 227882004607 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882004608 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882004609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 227882004610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882004611 dimer interface [polypeptide binding]; other site 227882004612 conserved gate region; other site 227882004613 putative PBP binding loops; other site 227882004614 ABC-ATPase subunit interface; other site 227882004615 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 227882004616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882004617 dimer interface [polypeptide binding]; other site 227882004618 conserved gate region; other site 227882004619 putative PBP binding loops; other site 227882004620 ABC-ATPase subunit interface; other site 227882004621 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 227882004622 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 227882004623 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 227882004624 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 227882004625 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882004626 Walker A/P-loop; other site 227882004627 ATP binding site [chemical binding]; other site 227882004628 Q-loop/lid; other site 227882004629 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14246 227882004630 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 227882004631 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882004632 Walker A/P-loop; other site 227882004633 ATP binding site [chemical binding]; other site 227882004634 Q-loop/lid; other site 227882004635 ABC transporter signature motif; other site 227882004636 Walker B; other site 227882004637 D-loop; other site 227882004638 H-loop/switch region; other site 227882004639 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882004640 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 227882004641 nudix motif; other site 227882004642 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 227882004643 active site 227882004644 tetramer interface [polypeptide binding]; other site 227882004645 Mg2+/Mn2+ binding site [ion binding]; other site 227882004646 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882004647 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 227882004648 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 227882004649 active site 227882004650 catalytic triad [active] 227882004651 Rhamnogalacturonase B, N-terminal; Region: RhgB_N; pfam09284 227882004652 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 227882004653 active site 227882004654 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 227882004655 putative sugar binding sites [chemical binding]; other site 227882004656 Q-X-W motif; other site 227882004657 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 227882004658 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 227882004659 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 227882004660 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 227882004661 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882004662 substrate binding pocket [chemical binding]; other site 227882004663 catalytic triad [active] 227882004664 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882004665 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882004666 DNA binding site [nucleotide binding] 227882004667 domain linker motif; other site 227882004668 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 227882004669 putative dimerization interface [polypeptide binding]; other site 227882004670 putative ligand binding site [chemical binding]; other site 227882004671 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 227882004672 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 227882004673 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 227882004674 Mitomycin C resistance protein (MRD); Region: MRD; cd07235 227882004675 dimer interface [polypeptide binding]; other site 227882004676 ligand binding site [chemical binding]; other site 227882004677 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 227882004678 Cupin domain; Region: Cupin_2; cl09118 227882004679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882004680 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 227882004681 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882004682 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882004683 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 227882004684 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 227882004685 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882004686 active site 227882004687 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 227882004688 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882004689 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 227882004690 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 227882004691 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 227882004692 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 227882004693 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 227882004694 Active Sites [active] 227882004695 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 227882004696 ligand-binding site [chemical binding]; other site 227882004697 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 227882004698 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 227882004699 Active Sites [active] 227882004700 Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009 227882004701 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 227882004702 CysD dimerization site [polypeptide binding]; other site 227882004703 G1 box; other site 227882004704 putative GEF interaction site [polypeptide binding]; other site 227882004705 GTP/Mg2+ binding site [chemical binding]; other site 227882004706 Switch I region; other site 227882004707 G2 box; other site 227882004708 G3 box; other site 227882004709 Switch II region; other site 227882004710 G4 box; other site 227882004711 G5 box; other site 227882004712 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695 227882004713 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-...; Region: Translation_factor_III; cl02786 227882004714 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-...; Region: Translation_factor_III; cl02786 227882004715 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 227882004716 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 227882004717 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 227882004718 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 227882004719 Walker A/P-loop; other site 227882004720 ATP binding site [chemical binding]; other site 227882004721 Q-loop/lid; other site 227882004722 ABC transporter signature motif; other site 227882004723 Walker B; other site 227882004724 D-loop; other site 227882004725 H-loop/switch region; other site 227882004726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882004727 dimer interface [polypeptide binding]; other site 227882004728 conserved gate region; other site 227882004729 putative PBP binding loops; other site 227882004730 ABC-ATPase subunit interface; other site 227882004731 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 227882004732 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416 227882004733 putative active site [active] 227882004734 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_C; cd03414 227882004735 putative active site [active] 227882004736 TIGR03086 family protein; Region: TIGR03086 227882004737 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 227882004738 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 227882004739 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 227882004740 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 227882004741 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 227882004742 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882004743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 227882004744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882004745 dimer interface [polypeptide binding]; other site 227882004746 conserved gate region; other site 227882004747 putative PBP binding loops; other site 227882004748 ABC-ATPase subunit interface; other site 227882004749 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882004750 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 227882004751 active site 227882004752 catalytic site [active] 227882004753 substrate binding site [chemical binding]; other site 227882004754 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 227882004755 tyramine oxidase; Provisional; Region: tynA; PRK11504 227882004756 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 227882004757 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 227882004758 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 227882004759 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 227882004760 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 227882004761 Transcriptional regulator [Transcription]; Region: LysR; COG0583 227882004762 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882004763 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 227882004764 dimerization interface [polypeptide binding]; other site 227882004765 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 227882004766 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882004767 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882004768 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 227882004769 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 227882004770 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 227882004771 active site 227882004772 Zn-binding site [ion binding]; other site 227882004773 Zn-binding site [ion binding]; other site 227882004774 Subtilisin inhibitor-like; Region: SSI; cl11594 227882004775 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 227882004776 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 227882004777 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 227882004778 phosphopeptide binding site; other site 227882004779 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 227882004780 Maltooligosyl trehalose synthase (MTSase) N-terminus domain. MTSase and maltooligosyl trehalose trehalohydrolase (MTHase) work together to produce trehalose. MTSase is responsible for converting the alpha-1,4-glucosidic linkage to an alpha,alpha-1,1-...; Region: MTHase_N_term; cd02853 227882004781 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 227882004782 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 227882004783 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882004784 active site 227882004785 ATP binding site [chemical binding]; other site 227882004786 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 227882004787 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 227882004788 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 227882004789 active site 227882004790 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated...; Region: PDZ; cl00117 227882004791 protein binding site [polypeptide binding]; other site 227882004792 Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687 227882004793 substrate binding pocket [chemical binding]; other site 227882004794 substrate-Mg2+ binding site; other site 227882004795 aspartate-rich region 1; other site 227882004796 active site lid residues [active] 227882004797 aspartate-rich region 2; other site 227882004798 Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687 227882004799 substrate binding pocket [chemical binding]; other site 227882004800 substrate-Mg2+ binding site; other site 227882004801 aspartate-rich region 1; other site 227882004802 active site lid residues [active] 227882004803 aspartate-rich region 2; other site 227882004804 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882004805 Cytochrome P450; Region: p450; cl12078 227882004806 Protein of unknown function DUF89; Region: DUF89; pfam01937 227882004807 Chitin binding domain; Region: Chitin_bind_3; cl03871 227882004808 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 227882004809 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 227882004810 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 227882004811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882004812 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882004813 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882004814 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 227882004815 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 227882004816 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 227882004817 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 227882004818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882004819 ATP binding site [chemical binding]; other site 227882004820 Mg2+ binding site [ion binding]; other site 227882004821 G-X-G motif; other site 227882004822 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 227882004823 Protein of unknown function (DUF742); Region: DUF742; pfam05331 227882004824 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 227882004825 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 227882004826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882004827 ABC-ATPase subunit interface; other site 227882004828 putative PBP binding loops; other site 227882004829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 227882004830 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 227882004831 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 227882004832 Walker A/P-loop; other site 227882004833 ATP binding site [chemical binding]; other site 227882004834 Q-loop/lid; other site 227882004835 ABC transporter signature motif; other site 227882004836 Walker B; other site 227882004837 D-loop; other site 227882004838 H-loop/switch region; other site 227882004839 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 227882004840 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 227882004841 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 227882004842 putative sugar binding sites [chemical binding]; other site 227882004843 Q-X-W motif; other site 227882004844 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 227882004845 putative ligand binding site [chemical binding]; other site 227882004846 Nitrate and nitrite sensing; Region: NIT; pfam08376 227882004847 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 227882004848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882004849 ATP binding site [chemical binding]; other site 227882004850 Mg2+ binding site [ion binding]; other site 227882004851 G-X-G motif; other site 227882004852 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 227882004853 Protein of unknown function (DUF742); Region: DUF742; pfam05331 227882004854 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 227882004855 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 227882004856 G1 box; other site 227882004857 GTP/Mg2+ binding site [chemical binding]; other site 227882004858 G2 box; other site 227882004859 Switch I region; other site 227882004860 G3 box; other site 227882004861 Switch II region; other site 227882004862 G4 box; other site 227882004863 G5 box; other site 227882004864 ApbE family; Region: ApbE; cl00643 227882004865 FMN-binding domain; Region: FMN_bind; cl01081 227882004866 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 227882004867 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 227882004868 FAD binding pocket [chemical binding]; other site 227882004869 FAD binding motif [chemical binding]; other site 227882004870 phosphate binding motif [ion binding]; other site 227882004871 beta-alpha-beta structure motif; other site 227882004872 NAD binding pocket [chemical binding]; other site 227882004873 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 227882004874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882004875 active site 227882004876 phosphorylation site [posttranslational modification] 227882004877 intermolecular recognition site; other site 227882004878 dimerization interface [polypeptide binding]; other site 227882004879 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882004880 DNA binding site [nucleotide binding] 227882004881 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882004882 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 227882004883 dimer interface [polypeptide binding]; other site 227882004884 phosphorylation site [posttranslational modification] 227882004885 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882004886 ATP binding site [chemical binding]; other site 227882004887 Mg2+ binding site [ion binding]; other site 227882004888 G-X-G motif; other site 227882004889 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 227882004890 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 227882004891 Ligand Binding Site [chemical binding]; other site 227882004892 Molecular Tunnel; other site 227882004893 stage V sporulation protein K; Region: spore_V_K; TIGR02881 227882004894 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882004895 Walker A motif; other site 227882004896 ATP binding site [chemical binding]; other site 227882004897 Walker B motif; other site 227882004898 arginine finger; other site 227882004899 CHAT domain; Region: CHAT; cl02083 227882004900 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 227882004901 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882004902 motif I; other site 227882004903 active site 227882004904 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 227882004905 SelR domain; Region: SelR; cl00369 227882004906 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 227882004907 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 227882004908 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 227882004909 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 227882004910 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 227882004911 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 227882004912 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 227882004913 active site clefts [active] 227882004914 zinc binding site [ion binding]; other site 227882004915 dimer interface [polypeptide binding]; other site 227882004916 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 227882004917 Sulfate transporter family; Region: Sulfate_transp; cl00967 227882004918 Sulfate transporter family; Region: Sulfate_transp; cl00967 227882004919 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 227882004920 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 227882004921 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 227882004922 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 227882004923 dimer interface [polypeptide binding]; other site 227882004924 putative active site [active] 227882004925 Protein of unknown function (DUF692); Region: DUF692; cl01263 227882004926 hypothetical protein; Provisional; Region: PRK05409 227882004927 Chlorite dismutase; Region: Chlor_dismutase; cl01280 227882004928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882004929 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882004930 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 227882004931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882004932 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 227882004933 Rhomboid family; Region: Rhomboid; cl11446 227882004934 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This...; Region: URO-D; cd00717 227882004935 substrate binding site [chemical binding]; other site 227882004936 active site 227882004937 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 227882004938 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882004939 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882004940 active site 227882004941 phosphorylation site [posttranslational modification] 227882004942 intermolecular recognition site; other site 227882004943 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882004944 DNA binding residues [nucleotide binding] 227882004945 dimerization interface [polypeptide binding]; other site 227882004946 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 227882004947 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 227882004948 putative active site [active] 227882004949 catalytic site [active] 227882004950 putative substrate binding site [chemical binding]; other site 227882004951 HRDC domain; Region: HRDC; cl02578 227882004952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 227882004953 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 227882004954 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 227882004955 dimer interface [polypeptide binding]; other site 227882004956 active site 227882004957 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 227882004958 substrate binding site [chemical binding]; other site 227882004959 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 227882004960 oxyanion hole (OAH) forming residues; other site 227882004961 trimer interface [polypeptide binding]; other site 227882004962 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 227882004963 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 227882004964 putative glycosyl transferase; Provisional; Region: PRK10073 227882004965 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 227882004966 active site 227882004967 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 227882004968 active site 227882004969 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 227882004970 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 227882004971 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 227882004972 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 227882004973 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882004974 NAD(P) binding site [chemical binding]; other site 227882004975 active site 227882004976 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 227882004977 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 227882004978 putative active site [active] 227882004979 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 227882004980 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882004981 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12571 227882004982 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 227882004983 TPP-binding site; other site 227882004984 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 227882004985 PYR/PP interface [polypeptide binding]; other site 227882004986 dimer interface [polypeptide binding]; other site 227882004987 TPP binding site [chemical binding]; other site 227882004988 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 227882004989 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 227882004990 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 227882004991 TM-ABC transporter signature motif; other site 227882004992 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882004993 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 227882004994 Walker A/P-loop; other site 227882004995 ATP binding site [chemical binding]; other site 227882004996 Q-loop/lid; other site 227882004997 ABC transporter signature motif; other site 227882004998 Walker B; other site 227882004999 D-loop; other site 227882005000 H-loop/switch region; other site 227882005001 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 227882005002 putative ligand binding site [chemical binding]; other site 227882005003 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882005004 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 227882005005 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882005006 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 227882005007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882005008 dimer interface [polypeptide binding]; other site 227882005009 conserved gate region; other site 227882005010 putative PBP binding loops; other site 227882005011 ABC-ATPase subunit interface; other site 227882005012 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 227882005013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882005014 putative PBP binding loops; other site 227882005015 dimer interface [polypeptide binding]; other site 227882005016 ABC-ATPase subunit interface; other site 227882005017 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882005018 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 227882005019 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 227882005020 alpha-1,2-mannosidase, putative; Region: aman2_put; TIGR01180 227882005021 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 227882005022 alpha-1,2-mannosidase, putative; Region: aman2_put; TIGR01180 227882005023 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 227882005024 Chitin binding domain; Region: Chitin_bind_3; cl03871 227882005025 Cellulose binding domain; Region: CBM_2; cl02709 227882005026 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882005027 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 227882005028 dimer interface [polypeptide binding]; other site 227882005029 phosphorylation site [posttranslational modification] 227882005030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882005031 ATP binding site [chemical binding]; other site 227882005032 Mg2+ binding site [ion binding]; other site 227882005033 G-X-G motif; other site 227882005034 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 227882005035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882005036 active site 227882005037 phosphorylation site [posttranslational modification] 227882005038 intermolecular recognition site; other site 227882005039 dimerization interface [polypeptide binding]; other site 227882005040 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882005041 DNA binding site [nucleotide binding] 227882005042 aconitate hydratase; Validated; Region: PRK09277 227882005043 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 227882005044 substrate binding site [chemical binding]; other site 227882005045 ligand binding site [chemical binding]; other site 227882005046 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 227882005047 substrate binding site [chemical binding]; other site 227882005048 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 227882005049 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 227882005050 putative active site [active] 227882005051 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882005052 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882005053 active site 227882005054 ATP binding site [chemical binding]; other site 227882005055 substrate binding site [chemical binding]; other site 227882005056 activation loop (A-loop); other site 227882005057 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 227882005058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882005059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882005060 putative substrate translocation pore; other site 227882005061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882005062 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882005063 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 227882005064 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882005065 active site 227882005066 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882005067 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 227882005068 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 227882005069 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882005070 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882005071 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 227882005072 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 227882005073 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 227882005074 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 227882005075 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882005076 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 227882005077 putative substrate translocation pore; other site 227882005078 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by...; Region: init_cond_enzymes; cd00827 227882005079 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 227882005080 dimer interface [polypeptide binding]; other site 227882005081 active site 227882005082 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 227882005083 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 227882005084 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882005085 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 227882005086 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882005087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882005088 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882005089 NAD(P) binding site [chemical binding]; other site 227882005090 active site 227882005091 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882005092 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882005093 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 227882005094 active site 227882005095 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882005096 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882005097 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882005098 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882005099 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 227882005100 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 227882005101 NAD(P) binding site [chemical binding]; other site 227882005102 catalytic residues [active] 227882005103 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 227882005104 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882005105 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 227882005106 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 227882005107 inhibitor-cofactor binding pocket; inhibition site 227882005108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882005109 catalytic residue [active] 227882005110 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 227882005111 hydrophobic ligand binding site; other site 227882005112 Flavin Reductases; Region: FlaRed; cl00801 227882005113 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 227882005114 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 227882005115 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 227882005116 dimer interface [polypeptide binding]; other site 227882005117 active site 227882005118 CoA binding pocket [chemical binding]; other site 227882005119 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 227882005120 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 227882005121 dimer interface [polypeptide binding]; other site 227882005122 active site 227882005123 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882005124 seryl-tRNA synthetase; Provisional; Region: PRK05431 227882005125 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 227882005126 dimer interface [polypeptide binding]; other site 227882005127 active site 227882005128 motif 1; other site 227882005129 motif 2; other site 227882005130 motif 3; other site 227882005131 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 227882005132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882005133 NAD(P) binding site [chemical binding]; other site 227882005134 active site 227882005135 Ferredoxin [Energy production and conversion]; Region: COG1146 227882005136 4Fe-4S binding domain; Region: Fer4; cl02805 227882005137 benzoate transport; Region: 2A0115; TIGR00895 227882005138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882005139 putative substrate translocation pore; other site 227882005140 Fatty acid desaturase; Region: FA_desaturase; pfam00487 227882005141 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These...; Region: Delta6-FADS-like; cd03506 227882005142 putative di-iron ligands [ion binding]; other site 227882005143 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 227882005144 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882005145 DNA binding site [nucleotide binding] 227882005146 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 227882005147 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 227882005148 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 227882005149 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 227882005150 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 227882005151 homotrimer interaction site [polypeptide binding]; other site 227882005152 putative active site [active] 227882005153 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882005154 active site 227882005155 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 227882005156 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882005157 PaaX-like protein; Region: PaaX; pfam07848 227882005158 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 227882005159 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 227882005160 Stf0 sulphotransferase; Region: Sulphotransf; cl01835 227882005161 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 227882005162 putative ADP-binding pocket [chemical binding]; other site 227882005163 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 227882005164 ligand-binding site [chemical binding]; other site 227882005165 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 227882005166 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 227882005167 Active Sites [active] 227882005168 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 227882005169 CysN_ATPS subfamily. CysN, together with protein CysD, form the ATP sulfurylase (ATPS) complex in some bacteria and lower eukaryotes. ATPS catalyzes the production of ATP sulfurylase (APS) and pyrophosphate (PPi) from ATP and sulfate. CysD, which...; Region: CysN_ATPS; cd04166 227882005170 G1 box; other site 227882005171 putative GEF interaction site [polypeptide binding]; other site 227882005172 GTP/Mg2+ binding site [chemical binding]; other site 227882005173 Switch I region; other site 227882005174 G2 box; other site 227882005175 CysD dimerization site [polypeptide binding]; other site 227882005176 G3 box; other site 227882005177 Switch II region; other site 227882005178 G4 box; other site 227882005179 G5 box; other site 227882005180 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NodQ_II; cd03695 227882005181 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of...; Region: CysN_NoDQ_III; cd04095 227882005182 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 227882005183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882005184 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 227882005185 active site 227882005186 FMN binding site [chemical binding]; other site 227882005187 substrate binding site [chemical binding]; other site 227882005188 homotetramer interface [polypeptide binding]; other site 227882005189 catalytic residue [active] 227882005190 enoyl-CoA hydratase; Provisional; Region: PRK08258 227882005191 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 227882005192 substrate binding site [chemical binding]; other site 227882005193 oxyanion hole (OAH) forming residues; other site 227882005194 trimer interface [polypeptide binding]; other site 227882005195 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882005196 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 227882005197 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882005198 ornithine carbamoyltransferase; Validated; Region: PRK02102 227882005199 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 227882005200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882005201 Amidinotransferase; Region: Amidinotransf; cl12043 227882005202 Arginine deiminase [Amino acid transport and metabolism]; Region: ArcA; COG2235 227882005203 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 227882005204 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 227882005205 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 227882005206 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882005207 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 227882005208 active site 227882005209 metal binding site [ion binding]; metal-binding site 227882005210 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 227882005211 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 227882005212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882005213 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 227882005214 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882005215 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 227882005216 Protein of unknown function (DUF552); Region: DUF552; cl00775 227882005217 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754 227882005218 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 227882005219 [4Fe-4S] binding site [ion binding]; other site 227882005220 molybdopterin cofactor binding site; other site 227882005221 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 227882005222 molybdopterin cofactor binding site; other site 227882005223 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 227882005224 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 227882005225 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 227882005226 FAD binding pocket [chemical binding]; other site 227882005227 FAD binding motif [chemical binding]; other site 227882005228 catalytic residues [active] 227882005229 NAD binding pocket [chemical binding]; other site 227882005230 phosphate binding motif [ion binding]; other site 227882005231 beta-alpha-beta structure motif; other site 227882005232 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882005233 High-affinity nickel-transport protein; Region: NicO; cl00964 227882005234 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 227882005235 Restriction endonuclease NaeI; Region: NaeI; pfam09126 227882005236 MoxR-like ATPases [General function prediction only]; Region: COG0714 227882005237 UvrD/REP helicase; Region: UvrD-helicase; cl14126 227882005238 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 227882005239 DNA binding residues [nucleotide binding] 227882005240 TOBE domain; Region: TOBE_2; cl01440 227882005241 TOBE domain; Region: TOBE_2; cl01440 227882005242 TOBE domain; Region: TOBE_2; cl01440 227882005243 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 227882005244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882005245 NAD(P) binding site [chemical binding]; other site 227882005246 active site 227882005247 Gas vesicle protein K; Region: GvpK; pfam05121 227882005248 Gas vesicle protein; Region: Gas_vesicle; cl02954 227882005249 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 227882005250 Gas vesicle protein; Region: Gas_vesicle; cl02954 227882005251 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 227882005252 putative hydrophobic ligand binding site [chemical binding]; other site 227882005253 Gas vesicle protein G; Region: GvpG; pfam05120 227882005254 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 227882005255 Gas vesicle protein; Region: Gas_vesicle; cl02954 227882005256 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 227882005257 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 227882005258 classical (c) SDRs; Region: SDR_c; cd05233 227882005259 NAD(P) binding site [chemical binding]; other site 227882005260 active site 227882005261 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 227882005262 putative active site [active] 227882005263 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 227882005264 Coenzyme A binding pocket [chemical binding]; other site 227882005265 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882005266 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 227882005267 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882005268 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 227882005269 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882005270 putative PBP binding loops; other site 227882005271 ABC-ATPase subunit interface; other site 227882005272 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 227882005273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882005274 dimer interface [polypeptide binding]; other site 227882005275 conserved gate region; other site 227882005276 putative PBP binding loops; other site 227882005277 ABC-ATPase subunit interface; other site 227882005278 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 227882005279 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 227882005280 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 227882005281 Walker A/P-loop; other site 227882005282 ATP binding site [chemical binding]; other site 227882005283 Q-loop/lid; other site 227882005284 ABC transporter signature motif; other site 227882005285 Walker B; other site 227882005286 D-loop; other site 227882005287 H-loop/switch region; other site 227882005288 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 227882005289 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 227882005290 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882005291 Walker A/P-loop; other site 227882005292 ATP binding site [chemical binding]; other site 227882005293 Q-loop/lid; other site 227882005294 ABC transporter signature motif; other site 227882005295 Walker B; other site 227882005296 D-loop; other site 227882005297 H-loop/switch region; other site 227882005298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882005299 NAD(P) binding site [chemical binding]; other site 227882005300 active site 227882005301 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 227882005302 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 227882005303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882005304 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 227882005305 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882005306 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882005307 active site 227882005308 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882005309 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882005310 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882005311 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 227882005312 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882005313 active site 227882005314 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882005315 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882005316 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882005317 putative NADP binding site [chemical binding]; other site 227882005318 active site 227882005319 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882005320 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 227882005321 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882005322 active site 227882005323 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882005324 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882005325 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882005326 putative NADP binding site [chemical binding]; other site 227882005327 active site 227882005328 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882005329 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882005330 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 227882005331 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 227882005332 classical (c) SDRs; Region: SDR_c; cd05233 227882005333 NAD(P) binding site [chemical binding]; other site 227882005334 active site 227882005335 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882005336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882005337 active site 227882005338 phosphorylation site [posttranslational modification] 227882005339 intermolecular recognition site; other site 227882005340 dimerization interface [polypeptide binding]; other site 227882005341 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882005342 DNA binding residues [nucleotide binding] 227882005343 dimerization interface [polypeptide binding]; other site 227882005344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882005345 S-adenosylmethionine binding site [chemical binding]; other site 227882005346 phosphoethanolamine N-methyltransferase; Region: PLN02336 227882005347 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882005348 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by...; Region: init_cond_enzymes; cd00827 227882005349 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 227882005350 dimer interface [polypeptide binding]; other site 227882005351 active site 227882005352 Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier...; Region: CLF; cd00832 227882005353 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 227882005354 active site 227882005355 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 227882005356 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 227882005357 dimer interface [polypeptide binding]; other site 227882005358 active site 227882005359 Cytochrome P450; Region: p450; cl12078 227882005360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882005361 hypothetical protein; Provisional; Region: PRK06126 227882005362 ABC-2 type transporter; Region: ABC2_membrane; cl11417 227882005363 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882005364 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 227882005365 Walker A/P-loop; other site 227882005366 ATP binding site [chemical binding]; other site 227882005367 Q-loop/lid; other site 227882005368 ABC transporter signature motif; other site 227882005369 Walker B; other site 227882005370 D-loop; other site 227882005371 H-loop/switch region; other site 227882005372 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882005373 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 227882005374 O-methyltransferase; Region: Methyltransf_2; pfam00891 227882005375 N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861 227882005376 putative hydrophobic ligand binding site [chemical binding]; other site 227882005377 N-terminal and C-terminal aromatase/cyclase domains of Streptomyces rimosus OtcD1 and related domains; Region: OtcD1_ARO-CYC_like; cd08861 227882005378 putative hydrophobic ligand binding site [chemical binding]; other site 227882005379 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 227882005380 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 227882005381 Cytochrome P450; Region: p450; cl12078 227882005382 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 227882005383 Clp amino terminal domain; Region: Clp_N; pfam02861 227882005384 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 227882005385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882005386 NAD(P) binding site [chemical binding]; other site 227882005387 active site 227882005388 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 227882005389 TRAM domain; Region: TRAM; cl01282 227882005390 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 227882005391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882005392 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 227882005393 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882005394 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 227882005395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882005396 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 227882005397 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 227882005398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882005399 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 227882005400 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 227882005401 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 227882005402 ssDNA binding site; other site 227882005403 generic binding surface II; other site 227882005404 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 227882005405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882005406 active site 227882005407 phosphorylation site [posttranslational modification] 227882005408 intermolecular recognition site; other site 227882005409 dimerization interface [polypeptide binding]; other site 227882005410 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882005411 DNA binding site [nucleotide binding] 227882005412 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 227882005413 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 227882005414 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 227882005415 Ligand Binding Site [chemical binding]; other site 227882005416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 227882005417 dimer interface [polypeptide binding]; other site 227882005418 phosphorylation site [posttranslational modification] 227882005419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882005420 ATP binding site [chemical binding]; other site 227882005421 Mg2+ binding site [ion binding]; other site 227882005422 G-X-G motif; other site 227882005423 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 227882005424 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 227882005425 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 227882005426 trimer interface [polypeptide binding]; other site 227882005427 active site 227882005428 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 227882005429 CoenzymeA binding site [chemical binding]; other site 227882005430 subunit interaction site [polypeptide binding]; other site 227882005431 PHB binding site; other site 227882005432 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 227882005433 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 227882005434 dimerization interface [polypeptide binding]; other site 227882005435 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 227882005436 dimer interface [polypeptide binding]; other site 227882005437 phosphorylation site [posttranslational modification] 227882005438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882005439 ATP binding site [chemical binding]; other site 227882005440 Mg2+ binding site [ion binding]; other site 227882005441 G-X-G motif; other site 227882005442 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 227882005443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882005444 active site 227882005445 phosphorylation site [posttranslational modification] 227882005446 intermolecular recognition site; other site 227882005447 dimerization interface [polypeptide binding]; other site 227882005448 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882005449 DNA binding site [nucleotide binding] 227882005450 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 227882005451 active site 227882005452 dimerization interface [polypeptide binding]; other site 227882005453 ferrochelatase; Reviewed; Region: hemH; PRK00035 227882005454 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 227882005455 C-terminal domain interface [polypeptide binding]; other site 227882005456 active site 227882005457 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 227882005458 active site 227882005459 N-terminal domain interface [polypeptide binding]; other site 227882005460 Major Facilitator Superfamily; Region: MFS_1; pfam07690 227882005461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 227882005462 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 227882005463 FAD binding domain; Region: FAD_binding_4; pfam01565 227882005464 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 227882005465 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 227882005466 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 227882005467 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 227882005468 active site residue [active] 227882005469 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 227882005470 active site residue [active] 227882005471 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 227882005472 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 227882005473 Thymidine kinase; Region: TK; cl00631 227882005474 Sulfatase; Region: Sulfatase; cl10460 227882005475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882005476 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 227882005477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882005478 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 227882005479 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 227882005480 dimerization domain swap beta strand [polypeptide binding]; other site 227882005481 regulatory protein interface [polypeptide binding]; other site 227882005482 active site 227882005483 regulatory phosphorylation site [posttranslational modification]; other site 227882005484 Transcriptional regulators [Transcription]; Region: FadR; COG2186 227882005485 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882005486 DNA-binding site [nucleotide binding]; DNA binding site 227882005487 FCD domain; Region: FCD; cl11656 227882005488 Peptidase family M23; Region: Peptidase_M23; pfam01551 227882005489 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 227882005490 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 227882005491 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 227882005492 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 227882005493 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 227882005494 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 227882005495 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 227882005496 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 227882005497 CAP-like domain; other site 227882005498 Active site [active] 227882005499 primary dimer interface [polypeptide binding]; other site 227882005500 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 227882005501 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 227882005502 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 227882005503 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 227882005504 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 227882005505 dimer interface [polypeptide binding]; other site 227882005506 Citrate synthase; Region: Citrate_synt; pfam00285 227882005507 active site 227882005508 citrylCoA binding site [chemical binding]; other site 227882005509 oxalacetate/citrate binding site [chemical binding]; other site 227882005510 coenzyme A binding site [chemical binding]; other site 227882005511 catalytic triad [active] 227882005512 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 227882005513 Citrate synthase; Region: Citrate_synt; pfam00285 227882005514 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A (...; Region: CS_ACL-C_CCL; cl00416 227882005515 oxalacetate binding site [chemical binding]; other site 227882005516 citrylCoA binding site [chemical binding]; other site 227882005517 coenzyme A binding site [chemical binding]; other site 227882005518 catalytic triad [active] 227882005519 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 227882005520 putative dimer interface [polypeptide binding]; other site 227882005521 putative [2Fe-2S] cluster binding site [ion binding]; other site 227882005522 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 227882005523 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 227882005524 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882005525 ATP binding site [chemical binding]; other site 227882005526 Mg2+ binding site [ion binding]; other site 227882005527 G-X-G motif; other site 227882005528 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 227882005529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882005530 active site 227882005531 phosphorylation site [posttranslational modification] 227882005532 intermolecular recognition site; other site 227882005533 dimerization interface [polypeptide binding]; other site 227882005534 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882005535 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 227882005536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882005537 dimer interface [polypeptide binding]; other site 227882005538 conserved gate region; other site 227882005539 putative PBP binding loops; other site 227882005540 ABC-ATPase subunit interface; other site 227882005541 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 227882005542 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 227882005543 Walker A/P-loop; other site 227882005544 ATP binding site [chemical binding]; other site 227882005545 Q-loop/lid; other site 227882005546 ABC transporter signature motif; other site 227882005547 Walker B; other site 227882005548 D-loop; other site 227882005549 H-loop/switch region; other site 227882005550 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 227882005551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882005552 active site 227882005553 phosphorylation site [posttranslational modification] 227882005554 intermolecular recognition site; other site 227882005555 dimerization interface [polypeptide binding]; other site 227882005556 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882005557 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 227882005558 Sodium:solute symporter family; Region: SSF; cl00456 227882005559 Protein of unknown function, DUF485; Region: DUF485; cl01231 227882005560 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882005561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882005562 active site 227882005563 phosphorylation site [posttranslational modification] 227882005564 intermolecular recognition site; other site 227882005565 dimerization interface [polypeptide binding]; other site 227882005566 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882005567 DNA binding residues [nucleotide binding] 227882005568 dimerization interface [polypeptide binding]; other site 227882005569 Histidine kinase; Region: HisKA_3; pfam07730 227882005570 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882005571 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 227882005572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882005573 ATP binding site [chemical binding]; other site 227882005574 Mg2+ binding site [ion binding]; other site 227882005575 G-X-G motif; other site 227882005576 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 227882005577 anchoring element; other site 227882005578 dimer interface [polypeptide binding]; other site 227882005579 ATP binding site [chemical binding]; other site 227882005580 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 227882005581 active site 227882005582 metal binding site [ion binding]; metal-binding site 227882005583 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 227882005584 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cd00190 227882005585 cleavage site 227882005586 active site 227882005587 substrate binding sites [chemical binding]; other site 227882005588 RNA polymerase sigma factor; Provisional; Region: PRK05901 227882005589 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 227882005590 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 227882005591 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882005592 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 227882005593 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882005594 DNA binding residues [nucleotide binding] 227882005595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882005596 DNA-binding site [nucleotide binding]; DNA binding site 227882005597 FCD domain; Region: FCD; cl11656 227882005598 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 227882005599 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882005600 Walker A/P-loop; other site 227882005601 ATP binding site [chemical binding]; other site 227882005602 Q-loop/lid; other site 227882005603 ABC transporter signature motif; other site 227882005604 Walker B; other site 227882005605 D-loop; other site 227882005606 H-loop/switch region; other site 227882005607 bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379 227882005608 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 227882005609 nudix motif; other site 227882005610 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 227882005611 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 227882005612 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 227882005613 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 227882005614 ATP binding site [chemical binding]; other site 227882005615 putative Mg++ binding site [ion binding]; other site 227882005616 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 227882005617 nucleotide binding region [chemical binding]; other site 227882005618 ATP-binding site [chemical binding]; other site 227882005619 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 227882005620 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 227882005621 RNA/DNA hybrid binding site [nucleotide binding]; other site 227882005622 active site 227882005623 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882005624 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882005625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882005626 Major Facilitator Superfamily; Region: MFS_1; pfam07690 227882005627 putative substrate translocation pore; other site 227882005628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882005629 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 227882005630 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 227882005631 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 227882005632 catalytic core [active] 227882005633 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 227882005634 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 227882005635 putative metal binding site [ion binding]; other site 227882005636 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 227882005637 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 227882005638 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 227882005639 active site 227882005640 dimer interface [polypeptide binding]; other site 227882005641 effector binding site; other site 227882005642 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 227882005643 TSCPD domain; Region: TSCPD; cl14834 227882005644 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 227882005645 ATP cone domain; Region: ATP-cone; pfam03477 227882005646 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882005647 LexA repressor; Validated; Region: PRK00215 227882005648 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (...; Region: S24_LexA-like; cd06529 227882005649 Catalytic site [active] 227882005650 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 227882005651 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882005652 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882005653 Siderophore biosynthesis protein domain; Region: AlcB; cl11000 227882005654 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 227882005655 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 227882005656 IucA / IucC family; Region: IucA_IucC; pfam04183 227882005657 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 227882005658 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 227882005659 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 227882005660 inhibitor-cofactor binding pocket; inhibition site 227882005661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882005662 catalytic residue [active] 227882005663 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 227882005664 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 227882005665 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 227882005666 G1 box; other site 227882005667 GTP/Mg2+ binding site [chemical binding]; other site 227882005668 Switch I region; other site 227882005669 G2 box; other site 227882005670 G3 box; other site 227882005671 Switch II region; other site 227882005672 G4 box; other site 227882005673 G5 box; other site 227882005674 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 227882005675 Zn binding site [ion binding]; other site 227882005676 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 227882005677 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 227882005678 synthetase active site [active] 227882005679 NTP binding site [chemical binding]; other site 227882005680 metal binding site [ion binding]; metal-binding site 227882005681 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 227882005682 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 227882005683 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 227882005684 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 227882005685 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 227882005686 IPP transferase; Region: IPPT; cl00403 227882005687 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 227882005688 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 227882005689 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 227882005690 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 227882005691 FeS/SAM binding site; other site 227882005692 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 227882005693 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 227882005694 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 227882005695 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 227882005696 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 227882005697 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882005698 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882005699 ATP binding site [chemical binding]; other site 227882005700 Mg2+ binding site [ion binding]; other site 227882005701 G-X-G motif; other site 227882005702 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 227882005703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882005704 active site 227882005705 phosphorylation site [posttranslational modification] 227882005706 intermolecular recognition site; other site 227882005707 dimerization interface [polypeptide binding]; other site 227882005708 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882005709 DNA binding site [nucleotide binding] 227882005710 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 227882005711 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 227882005712 Walker A/P-loop; other site 227882005713 ATP binding site [chemical binding]; other site 227882005714 Q-loop/lid; other site 227882005715 ABC transporter signature motif; other site 227882005716 Walker B; other site 227882005717 D-loop; other site 227882005718 H-loop/switch region; other site 227882005719 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 227882005720 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 227882005721 substrate binding pocket [chemical binding]; other site 227882005722 membrane-bound complex binding site; other site 227882005723 hinge residues; other site 227882005724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882005725 dimer interface [polypeptide binding]; other site 227882005726 conserved gate region; other site 227882005727 ABC-ATPase subunit interface; other site 227882005728 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 227882005729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882005730 dimer interface [polypeptide binding]; other site 227882005731 conserved gate region; other site 227882005732 putative PBP binding loops; other site 227882005733 ABC-ATPase subunit interface; other site 227882005734 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 227882005735 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 227882005736 Cysteine dioxygenase type I; Region: CDO_I; cl02350 227882005737 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 227882005738 active site residue [active] 227882005739 RecX family; Region: RecX; cl00936 227882005740 recombinase A; Provisional; Region: recA; PRK09354 227882005741 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 227882005742 hexamer interface [polypeptide binding]; other site 227882005743 Walker A motif; other site 227882005744 ATP binding site [chemical binding]; other site 227882005745 Walker B motif; other site 227882005746 Domain of unknown function DUF20; Region: UPF0118; cl00465 227882005747 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 227882005748 AzlC protein; Region: AzlC; cl00570 227882005749 Cupin domain; Region: Cupin_2; cl09118 227882005750 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 227882005751 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 227882005752 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 227882005753 ATP binding site [chemical binding]; other site 227882005754 putative Mg++ binding site [ion binding]; other site 227882005755 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 227882005756 nucleotide binding region [chemical binding]; other site 227882005757 ATP-binding site [chemical binding]; other site 227882005758 DEAD/H associated; Region: DEAD_assoc; pfam08494 227882005759 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 227882005760 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 227882005761 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 227882005762 putative DNA binding site [nucleotide binding]; other site 227882005763 catalytic residue [active] 227882005764 putative H2TH interface [polypeptide binding]; other site 227882005765 putative catalytic residues [active] 227882005766 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 227882005767 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 227882005768 classical (c) SDRs; Region: SDR_c; cd05233 227882005769 NAD(P) binding site [chemical binding]; other site 227882005770 active site 227882005771 Ferritin-like domain; Region: Ferritin; pfam00210 227882005772 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 227882005773 dimerization interface [polypeptide binding]; other site 227882005774 DPS ferroxidase diiron center [ion binding]; other site 227882005775 ion pore; other site 227882005776 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882005777 Competence-damaged protein; Region: CinA; cl00666 227882005778 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 227882005779 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 227882005780 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 227882005781 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 227882005782 FeS/SAM binding site; other site 227882005783 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882005784 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 227882005785 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882005786 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 227882005787 Response regulator receiver domain; Region: Response_reg; pfam00072 227882005788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882005789 active site 227882005790 phosphorylation site [posttranslational modification] 227882005791 intermolecular recognition site; other site 227882005792 dimerization interface [polypeptide binding]; other site 227882005793 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882005794 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882005795 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882005796 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882005797 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882005798 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 227882005799 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882005800 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882005801 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882005802 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882005803 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882005804 GAF domain; Region: GAF; cl00853 227882005805 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 227882005806 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882005807 ATP binding site [chemical binding]; other site 227882005808 Mg2+ binding site [ion binding]; other site 227882005809 G-X-G motif; other site 227882005810 Response regulator receiver domain; Region: Response_reg; pfam00072 227882005811 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882005812 active site 227882005813 phosphorylation site [posttranslational modification] 227882005814 intermolecular recognition site; other site 227882005815 dimerization interface [polypeptide binding]; other site 227882005816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882005817 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 227882005818 putative active site [active] 227882005819 heme pocket [chemical binding]; other site 227882005820 GAF domain; Region: GAF; cl00853 227882005821 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882005822 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882005823 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882005824 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 227882005825 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882005826 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 227882005827 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 227882005828 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 227882005829 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 227882005830 dihydrodipicolinate synthase; Region: dapA; TIGR00674 227882005831 dimer interface [polypeptide binding]; other site 227882005832 active site 227882005833 catalytic residue [active] 227882005834 Thymidylate synthase complementing protein; Region: Thy1; cl03630 227882005835 dihydrodipicolinate reductase; Provisional; Region: PRK00048 227882005836 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882005837 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 227882005838 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 227882005839 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 227882005840 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 227882005841 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 227882005842 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 227882005843 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 227882005844 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 227882005845 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 227882005846 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 227882005847 putative nucleic acid binding region [nucleotide binding]; other site 227882005848 G-X-X-G motif; other site 227882005849 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 227882005850 RNA binding site [nucleotide binding]; other site 227882005851 domain interface; other site 227882005852 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 227882005853 16S/18S rRNA binding site [nucleotide binding]; other site 227882005854 S13e-L30e interaction site [polypeptide binding]; other site 227882005855 25S rRNA binding site [nucleotide binding]; other site 227882005856 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 227882005857 FOG: WD40-like repeat [Function unknown]; Region: COG1520 227882005858 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 227882005859 FOG: WD40-like repeat [Function unknown]; Region: COG1520 227882005860 secretion protein snm4; Region: sec_mycoba_snm4; TIGR02958 227882005861 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 227882005862 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882005863 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 227882005864 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882005865 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882005866 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882005867 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 227882005868 Proteins of 100 residues with WXG; Region: WXG100; cl02005 227882005869 Proteins of 100 residues with WXG; Region: WXG100; cl02005 227882005870 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 227882005871 active site 227882005872 catalytic residues [active] 227882005873 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 227882005874 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 227882005875 active site 227882005876 catalytic residues [active] 227882005877 Protein of unknown function (DUF690); Region: DUF690; cl04939 227882005878 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 227882005879 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 227882005880 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 227882005881 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 227882005882 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 227882005883 active site 227882005884 Riboflavin kinase; Region: Flavokinase; cl03312 227882005885 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 227882005886 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 227882005887 RNA binding site [nucleotide binding]; other site 227882005888 active site 227882005889 Ribosome-binding factor A; Region: RBFA; cl00542 227882005890 Protein of unknown function (DUF503); Region: DUF503; cl00669 227882005891 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 227882005892 translation initiation factor IF-2; Region: IF-2; TIGR00487 227882005893 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 227882005894 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 227882005895 G1 box; other site 227882005896 putative GEF interaction site [polypeptide binding]; other site 227882005897 GTP/Mg2+ binding site [chemical binding]; other site 227882005898 Switch I region; other site 227882005899 G2 box; other site 227882005900 G3 box; other site 227882005901 Switch II region; other site 227882005902 G4 box; other site 227882005903 G5 box; other site 227882005904 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 227882005905 Translation-initiation factor 2; Region: IF-2; pfam11987 227882005906 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 227882005907 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 227882005908 putative RNA binding cleft [nucleotide binding]; other site 227882005909 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 227882005910 NusA N-terminal domain; Region: NusA_N; pfam08529 227882005911 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 227882005912 RNA binding site [nucleotide binding]; other site 227882005913 homodimer interface [polypeptide binding]; other site 227882005914 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 227882005915 G-X-X-G motif; other site 227882005916 ribosome maturation protein RimP; Reviewed; Region: PRK00092 227882005917 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 227882005918 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl10490 227882005919 prolyl-tRNA synthetase; Provisional; Region: PRK09194 227882005920 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 227882005921 dimer interface [polypeptide binding]; other site 227882005922 motif 1; other site 227882005923 active site 227882005924 motif 2; other site 227882005925 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 227882005926 putative deacylase active site [active] 227882005927 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 227882005928 active site 227882005929 motif 3; other site 227882005930 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 227882005931 anticodon binding site; other site 227882005932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882005933 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882005934 Predicted acetyltransferase [General function prediction only]; Region: COG3393 227882005935 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882005936 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 227882005937 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 227882005938 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 227882005939 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 227882005940 active site 227882005941 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 227882005942 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 227882005943 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 227882005944 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 227882005945 Intermediate filament tail domain; Region: IF_tail; pfam00932 227882005946 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 227882005947 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882005948 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 227882005949 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 227882005950 nucleotide binding region [chemical binding]; other site 227882005951 ATP-binding site [chemical binding]; other site 227882005952 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882005953 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 227882005954 active site 227882005955 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 227882005956 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882005957 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882005958 DNA binding site [nucleotide binding] 227882005959 domain linker motif; other site 227882005960 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 227882005961 dimerization interface [polypeptide binding]; other site 227882005962 ligand binding site [chemical binding]; other site 227882005963 putative alpha-glucosidase; Provisional; Region: PRK10658 227882005964 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 227882005965 putative active site [active] 227882005966 putative catalytic site [active] 227882005967 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 227882005968 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 227882005969 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 227882005970 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 227882005971 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 227882005972 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 227882005973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882005974 dimer interface [polypeptide binding]; other site 227882005975 conserved gate region; other site 227882005976 putative PBP binding loops; other site 227882005977 ABC-ATPase subunit interface; other site 227882005978 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 227882005979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882005980 dimer interface [polypeptide binding]; other site 227882005981 conserved gate region; other site 227882005982 putative PBP binding loops; other site 227882005983 ABC-ATPase subunit interface; other site 227882005984 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 227882005985 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882005986 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 227882005987 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 227882005988 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 227882005989 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 227882005990 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 227882005991 ligand binding site [chemical binding]; other site 227882005992 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 227882005993 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 227882005994 NAD(P) binding site [chemical binding]; other site 227882005995 catalytic residues [active] 227882005996 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 227882005997 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 227882005998 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 227882005999 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 227882006000 inhibitor-cofactor binding pocket; inhibition site 227882006001 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882006002 catalytic residue [active] 227882006003 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 227882006004 active site 227882006005 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 227882006006 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 227882006007 Interdomain contacts; other site 227882006008 Cytokine receptor motif; other site 227882006009 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18 (...; Region: GH18_chitinase_D-like; cd02871 227882006010 Glyco_18 domain; Region: Glyco_18; smart00636 227882006011 putative active site [active] 227882006012 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 227882006013 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 227882006014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882006015 dimer interface [polypeptide binding]; other site 227882006016 conserved gate region; other site 227882006017 putative PBP binding loops; other site 227882006018 ABC-ATPase subunit interface; other site 227882006019 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 227882006020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882006021 putative PBP binding loops; other site 227882006022 dimer interface [polypeptide binding]; other site 227882006023 ABC-ATPase subunit interface; other site 227882006024 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 227882006025 PotA is an ABC-type transporter and the ATPase component of the spermidine/putrescine-preferential uptake system consisting of PotA, -B, -C, and -D. PotA has two domains with the N-terminal domain containing the ATPase activity and the residues...; Region: ABC_PotA_N; cd03300 227882006026 Walker A/P-loop; other site 227882006027 ATP binding site [chemical binding]; other site 227882006028 Q-loop/lid; other site 227882006029 ABC transporter signature motif; other site 227882006030 Walker B; other site 227882006031 D-loop; other site 227882006032 H-loop/switch region; other site 227882006033 TOBE domain; Region: TOBE_2; cl01440 227882006034 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 227882006035 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882006036 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 227882006037 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 227882006038 tetrameric interface [polypeptide binding]; other site 227882006039 NAD binding site [chemical binding]; other site 227882006040 catalytic residues [active] 227882006041 substrate binding site [chemical binding]; other site 227882006042 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 227882006043 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 227882006044 active site 227882006045 purine riboside binding site [chemical binding]; other site 227882006046 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 227882006047 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 227882006048 active site 227882006049 catalytic site [active] 227882006050 metal binding site [ion binding]; metal-binding site 227882006051 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 227882006052 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882006053 Clp protease ATP binding subunit; Region: clpC; CHL00095 227882006054 Clp amino terminal domain; Region: Clp_N; pfam02861 227882006055 Clp amino terminal domain; Region: Clp_N; pfam02861 227882006056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882006057 Walker A motif; other site 227882006058 ATP binding site [chemical binding]; other site 227882006059 Walker B motif; other site 227882006060 arginine finger; other site 227882006061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882006062 Walker A motif; other site 227882006063 ATP binding site [chemical binding]; other site 227882006064 Walker B motif; other site 227882006065 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 227882006066 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882006067 OsmC-like protein; Region: OsmC; cl00767 227882006068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882006069 putative substrate translocation pore; other site 227882006070 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 227882006071 FMN binding site [chemical binding]; other site 227882006072 substrate binding site [chemical binding]; other site 227882006073 putative catalytic residue [active] 227882006074 Sulfate transporter family; Region: Sulfate_transp; cl00967 227882006075 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 227882006076 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882006077 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 227882006078 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 227882006079 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 227882006080 tetrameric interface [polypeptide binding]; other site 227882006081 NAD binding site [chemical binding]; other site 227882006082 catalytic residues [active] 227882006083 substrate binding site [chemical binding]; other site 227882006084 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 227882006085 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882006086 hypothetical protein; Provisional; Region: PRK06541 227882006087 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 227882006088 inhibitor-cofactor binding pocket; inhibition site 227882006089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882006090 catalytic residue [active] 227882006091 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 227882006092 Walker A/P-loop; other site 227882006093 ATP binding site [chemical binding]; other site 227882006094 Q-loop/lid; other site 227882006095 ABC transporter signature motif; other site 227882006096 Walker B; other site 227882006097 D-loop; other site 227882006098 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 227882006099 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 227882006100 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 227882006101 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882006102 Walker A/P-loop; other site 227882006103 ATP binding site [chemical binding]; other site 227882006104 Q-loop/lid; other site 227882006105 ABC transporter signature motif; other site 227882006106 Walker B; other site 227882006107 D-loop; other site 227882006108 H-loop/switch region; other site 227882006109 TOBE domain; Region: TOBE_2; cl01440 227882006110 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 227882006111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882006112 dimer interface [polypeptide binding]; other site 227882006113 conserved gate region; other site 227882006114 putative PBP binding loops; other site 227882006115 ABC-ATPase subunit interface; other site 227882006116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882006117 dimer interface [polypeptide binding]; other site 227882006118 conserved gate region; other site 227882006119 putative PBP binding loops; other site 227882006120 ABC-ATPase subunit interface; other site 227882006121 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 227882006122 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882006123 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 227882006124 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 227882006125 FeS/SAM binding site; other site 227882006126 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 227882006127 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 227882006128 hinge region; other site 227882006129 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 227882006130 putative nucleotide binding site [chemical binding]; other site 227882006131 uridine monophosphate binding site [chemical binding]; other site 227882006132 homohexameric interface [polypeptide binding]; other site 227882006133 elongation factor Ts; Provisional; Region: tsf; PRK09377 227882006134 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 227882006135 Elongation factor TS; Region: EF_TS; pfam00889 227882006136 Elongation factor TS; Region: EF_TS; pfam00889 227882006137 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 227882006138 rRNA interaction site [nucleotide binding]; other site 227882006139 S8 interaction site; other site 227882006140 putative laminin-1 binding site; other site 227882006141 Peptidase family M23; Region: Peptidase_M23; pfam01551 227882006142 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882006143 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 227882006144 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882006145 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 227882006146 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882006147 DNA binding residues [nucleotide binding] 227882006148 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 227882006149 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 227882006150 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 227882006151 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 227882006152 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882006153 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 227882006154 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 227882006155 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 227882006156 nudix motif; other site 227882006157 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 227882006158 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 227882006159 Catalytic site [active] 227882006160 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 227882006161 Catalytic site [active] 227882006162 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 227882006163 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 227882006164 Catalytic site [active] 227882006165 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 227882006166 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 227882006167 Catalytic site [active] 227882006168 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 227882006169 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 227882006170 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 227882006171 RimM N-terminal domain; Region: RimM; pfam01782 227882006172 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 227882006173 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 227882006174 prolyl-tRNA synthetase; Provisional; Region: PRK08661 227882006175 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_arch_euk; cd00778 227882006176 dimer interface [polypeptide binding]; other site 227882006177 motif 1; other site 227882006178 active site 227882006179 motif 2; other site 227882006180 motif 3; other site 227882006181 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible...; Region: HGTP_anticodon; cl00266 227882006182 anticodon binding site; other site 227882006183 signal recognition particle protein; Provisional; Region: PRK10867 227882006184 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 227882006185 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 227882006186 P loop; other site 227882006187 GTP binding site [chemical binding]; other site 227882006188 Signal peptide binding domain; Region: SRP_SPB; pfam02978 227882006189 PII uridylyl-transferase; Provisional; Region: PRK03381 227882006190 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 227882006191 metal binding triad; other site 227882006192 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 227882006193 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 227882006194 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 227882006195 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 227882006196 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 227882006197 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 227882006198 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 227882006199 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 227882006200 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 227882006201 Purine-cytosine permease and related proteins [Nucleotide transport and metabolism]; Region: CodB; COG1457 227882006202 Sodium:solute symporter family; Region: SSF; cl00456 227882006203 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882006204 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 227882006205 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 227882006206 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882006207 putative substrate translocation pore; other site 227882006208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882006209 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 227882006210 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 227882006211 Walker A/P-loop; other site 227882006212 ATP binding site [chemical binding]; other site 227882006213 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 227882006214 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 227882006215 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 227882006216 ABC transporter signature motif; other site 227882006217 Walker B; other site 227882006218 D-loop; other site 227882006219 H-loop/switch region; other site 227882006220 Acylphosphatase; Region: Acylphosphatase; cl00551 227882006221 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 227882006222 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 227882006223 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882006224 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 227882006225 Beta-lactamase; Region: Beta-lactamase; cl01009 227882006226 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 227882006227 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 227882006228 DNA binding site [nucleotide binding] 227882006229 catalytic residue [active] 227882006230 H2TH interface [polypeptide binding]; other site 227882006231 putative catalytic residues [active] 227882006232 turnover-facilitating residue; other site 227882006233 intercalation triad [nucleotide binding]; other site 227882006234 8OG recognition residue [nucleotide binding]; other site 227882006235 putative reading head residues; other site 227882006236 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 227882006237 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 227882006238 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 227882006239 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 227882006240 dimerization interface [polypeptide binding]; other site 227882006241 active site 227882006242 metal binding site [ion binding]; metal-binding site 227882006243 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 227882006244 dsRNA binding site [nucleotide binding]; other site 227882006245 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 227882006246 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 227882006247 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 227882006248 active site 227882006249 (T/H)XGH motif; other site 227882006250 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882006251 S-adenosylmethionine binding site [chemical binding]; other site 227882006252 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 227882006253 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 227882006254 generic binding surface II; other site 227882006255 ssDNA binding site; other site 227882006256 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 227882006257 Hom_end-associated Hint; Region: Hom_end_hint; pfam05203 227882006258 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 227882006259 putative Mg++ binding site [ion binding]; other site 227882006260 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 227882006261 nucleotide binding region [chemical binding]; other site 227882006262 ATP-binding site [chemical binding]; other site 227882006263 HSP90 family protein; Provisional; Region: PRK14083 227882006264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882006265 ATP binding site [chemical binding]; other site 227882006266 Mg2+ binding site [ion binding]; other site 227882006267 G-X-G motif; other site 227882006268 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 227882006269 DAK2 domain; Region: Dak2; cl03685 227882006270 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 227882006271 thiamine monophosphate kinase; Provisional; Region: PRK05731 227882006272 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 227882006273 ATP binding site [chemical binding]; other site 227882006274 dimerization interface [polypeptide binding]; other site 227882006275 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882006276 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 227882006277 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 227882006278 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 227882006279 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 227882006280 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 227882006281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882006282 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 227882006283 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 227882006284 putative acyl-acceptor binding pocket; other site 227882006285 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 227882006286 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 227882006287 IHF dimer interface [polypeptide binding]; other site 227882006288 IHF - DNA interface [nucleotide binding]; other site 227882006289 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 227882006290 substrate binding site [chemical binding]; other site 227882006291 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 227882006292 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 227882006293 substrate binding site [chemical binding]; other site 227882006294 ligand binding site [chemical binding]; other site 227882006295 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882006296 Transcriptional regulator [Transcription]; Region: IclR; COG1414 227882006297 Bacterial transcriptional regulator; Region: IclR; pfam01614 227882006298 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg5; cd04780 227882006299 DNA binding residues [nucleotide binding] 227882006300 putative dimer interface [polypeptide binding]; other site 227882006301 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 227882006302 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 227882006303 motif II; other site 227882006304 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 227882006305 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 227882006306 active site 227882006307 HIGH motif; other site 227882006308 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 227882006309 active site 227882006310 KMSKS motif; other site 227882006311 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 227882006312 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 227882006313 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 227882006314 Nitrate and nitrite sensing; Region: NIT; pfam08376 227882006315 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882006316 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 227882006317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882006318 ATP binding site [chemical binding]; other site 227882006319 Mg2+ binding site [ion binding]; other site 227882006320 G-X-G motif; other site 227882006321 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 227882006322 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 227882006323 Protein of unknown function (DUF742); Region: DUF742; pfam05331 227882006324 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 227882006325 Switch I region; other site 227882006326 G3 box; other site 227882006327 Switch II region; other site 227882006328 GTP/Mg2+ binding site [chemical binding]; other site 227882006329 G4 box; other site 227882006330 G5 box; other site 227882006331 Nitrate and nitrite sensing; Region: NIT; pfam08376 227882006332 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882006333 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 227882006334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882006335 ATP binding site [chemical binding]; other site 227882006336 Mg2+ binding site [ion binding]; other site 227882006337 G-X-G motif; other site 227882006338 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 227882006339 Protein of unknown function (DUF742); Region: DUF742; pfam05331 227882006340 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 227882006341 Switch I region; other site 227882006342 G3 box; other site 227882006343 Switch II region; other site 227882006344 GTP/Mg2+ binding site [chemical binding]; other site 227882006345 G4 box; other site 227882006346 G5 box; other site 227882006347 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 227882006348 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 227882006349 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 227882006350 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues...; Region: GAG_Lyase; cd01083 227882006351 substrate binding site [chemical binding]; other site 227882006352 catalytic residues [active] 227882006353 Polysaccharide lyase family 8, C-terminal beta-sandwich domain; Region: Lyase_8_C; pfam02884 227882006354 YceI-like domain; Region: YceI; cl01001 227882006355 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292 227882006356 Calx-beta domain; Region: Calx-beta; cl02522 227882006357 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 227882006358 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 227882006359 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 227882006360 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 227882006361 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 227882006362 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 227882006363 putative sugar binding sites [chemical binding]; other site 227882006364 Q-X-W motif; other site 227882006365 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 227882006366 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 227882006367 active site 227882006368 catalytic residues [active] 227882006369 metal binding site [ion binding]; metal-binding site 227882006370 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 227882006371 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 227882006372 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882006373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882006374 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 227882006375 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 227882006376 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 227882006377 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882006378 agmatine deiminase; Region: agmatine_aguA; TIGR03380 227882006379 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 227882006380 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 227882006381 urease subunit alpha; Reviewed; Region: ureC; PRK13207 227882006382 subunit interactions [polypeptide binding]; other site 227882006383 active site 227882006384 flap region; other site 227882006385 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 227882006386 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cl00532 227882006387 alpha-gamma subunit interface [polypeptide binding]; other site 227882006388 beta-gamma subunit interface [polypeptide binding]; other site 227882006389 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407 227882006390 alpha-beta subunit interface [polypeptide binding]; other site 227882006391 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 227882006392 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 227882006393 homodimer interface [polypeptide binding]; other site 227882006394 substrate-cofactor binding pocket; other site 227882006395 catalytic residue [active] 227882006396 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 227882006397 isocitrate dehydrogenase; Validated; Region: PRK06451 227882006398 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 227882006399 active site 227882006400 metal binding site [ion binding]; metal-binding site 227882006401 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882006402 haloalkane dehalogenase; Provisional; Region: PRK03592 227882006403 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 227882006404 NAD(P) binding site [chemical binding]; other site 227882006405 catalytic residues [active] 227882006406 Proline dehydrogenase; Region: Pro_dh; cl03282 227882006407 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 227882006408 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882006409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882006410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882006411 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 227882006412 putative substrate translocation pore; other site 227882006413 Predicted ATPase [General function prediction only]; Region: COG3899 227882006414 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882006415 DNA binding residues [nucleotide binding] 227882006416 dimerization interface [polypeptide binding]; other site 227882006417 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 227882006418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882006419 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 227882006420 putative L-serine binding site [chemical binding]; other site 227882006421 ketol-acid reductoisomerase; Provisional; Region: PRK05479 227882006422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882006423 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 227882006424 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 227882006425 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 227882006426 putative valine binding site [chemical binding]; other site 227882006427 dimer interface [polypeptide binding]; other site 227882006428 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 227882006429 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 227882006430 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 227882006431 PYR/PP interface [polypeptide binding]; other site 227882006432 dimer interface [polypeptide binding]; other site 227882006433 TPP binding site [chemical binding]; other site 227882006434 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 227882006435 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 227882006436 TPP-binding site [chemical binding]; other site 227882006437 dimer interface [polypeptide binding]; other site 227882006438 PAS domain S-box; Region: sensory_box; TIGR00229 227882006439 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 227882006440 putative active site [active] 227882006441 heme pocket [chemical binding]; other site 227882006442 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 227882006443 metal binding site [ion binding]; metal-binding site 227882006444 active site 227882006445 I-site; other site 227882006446 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 227882006447 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882006448 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 227882006449 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 227882006450 active site 227882006451 catalytic tetrad [active] 227882006452 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 227882006453 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 227882006454 Predicted ATPase [General function prediction only]; Region: COG3899 227882006455 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882006456 DNA binding residues [nucleotide binding] 227882006457 dimerization interface [polypeptide binding]; other site 227882006458 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 227882006459 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882006460 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 227882006461 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 227882006462 GatB domain; Region: GatB_Yqey; cl11497 227882006463 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 227882006464 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 227882006465 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 227882006466 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 227882006467 metal binding site [ion binding]; metal-binding site 227882006468 active site 227882006469 I-site; other site 227882006470 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 227882006471 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 227882006472 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 227882006473 nucleotide binding pocket [chemical binding]; other site 227882006474 K-X-D-G motif; other site 227882006475 catalytic site [active] 227882006476 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 227882006477 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 227882006478 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 227882006479 Dimer interface [polypeptide binding]; other site 227882006480 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step...; Region: CIMS_like; cd03310 227882006481 short chain dehydrogenase; Provisional; Region: PRK08219 227882006482 classical (c) SDRs; Region: SDR_c; cd05233 227882006483 NAD(P) binding site [chemical binding]; other site 227882006484 active site 227882006485 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 227882006486 Domain of unknown function (DUF427); Region: DUF427; cl00998 227882006487 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 227882006488 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 227882006489 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 227882006490 amidase catalytic site [active] 227882006491 Zn binding residues [ion binding]; other site 227882006492 substrate binding site [chemical binding]; other site 227882006493 multicopper oxidase; Provisional; Region: PRK10965 227882006494 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 227882006495 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 227882006496 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882006497 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 227882006498 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 227882006499 catalytic residue [active] 227882006500 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 227882006501 Predicted transcriptional regulator [Transcription]; Region: COG2378 227882006502 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882006503 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 227882006504 TIGR03086 family protein; Region: TIGR03086 227882006505 Predicted membrane protein [Function unknown]; Region: COG2860 227882006506 UPF0126 domain; Region: UPF0126; pfam03458 227882006507 UPF0126 domain; Region: UPF0126; pfam03458 227882006508 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 227882006509 Zn binding site [ion binding]; other site 227882006510 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 227882006511 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 227882006512 Walker A/P-loop; other site 227882006513 ATP binding site [chemical binding]; other site 227882006514 Q-loop/lid; other site 227882006515 ABC transporter signature motif; other site 227882006516 Walker B; other site 227882006517 D-loop; other site 227882006518 H-loop/switch region; other site 227882006519 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 227882006520 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 227882006521 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 227882006522 Walker A/P-loop; other site 227882006523 ATP binding site [chemical binding]; other site 227882006524 Q-loop/lid; other site 227882006525 ABC transporter signature motif; other site 227882006526 Walker B; other site 227882006527 D-loop; other site 227882006528 H-loop/switch region; other site 227882006529 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 227882006530 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 227882006531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882006532 dimer interface [polypeptide binding]; other site 227882006533 conserved gate region; other site 227882006534 putative PBP binding loops; other site 227882006535 ABC-ATPase subunit interface; other site 227882006536 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 227882006537 peptide binding site [polypeptide binding]; other site 227882006538 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 227882006539 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 227882006540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882006541 dimer interface [polypeptide binding]; other site 227882006542 conserved gate region; other site 227882006543 putative PBP binding loops; other site 227882006544 ABC-ATPase subunit interface; other site 227882006545 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882006546 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 227882006547 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 227882006548 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 227882006549 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 227882006550 lipoyl attachment site [posttranslational modification]; other site 227882006551 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 227882006552 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 227882006553 dimer interface [polypeptide binding]; other site 227882006554 glycine-pyridoxal phosphate binding site [chemical binding]; other site 227882006555 active site 227882006556 folate binding site [chemical binding]; other site 227882006557 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 227882006558 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 227882006559 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 227882006560 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 227882006561 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 227882006562 active site 227882006563 MOSC domain; Region: MOSC; pfam03473 227882006564 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 227882006565 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cd00051 227882006566 Ca2+ binding site [ion binding]; other site 227882006567 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 227882006568 DNA binding residues [nucleotide binding] 227882006569 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882006570 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 227882006571 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 227882006572 Oxysterol-binding protein; Region: Oxysterol_BP; pfam01237 227882006573 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 227882006574 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 227882006575 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 227882006576 substrate binding site [chemical binding]; other site 227882006577 oxyanion hole (OAH) forming residues; other site 227882006578 trimer interface [polypeptide binding]; other site 227882006579 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 227882006580 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 227882006581 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 227882006582 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 227882006583 Glycogen_debranching_enzyme N-terminal domain. Glycogen debranching enzymes have both 4-alpha-glucanotransferase and amylo-1,6-glucosidase activities. As a transferase it transfers a segment of a 1,4-alpha-D-glucan to a new 4-position in an acceptor...; Region: Glycogen_debranching_enzyme_N_term; cd02856 227882006584 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 227882006585 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 227882006586 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 227882006587 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882006588 Walker A/P-loop; other site 227882006589 ATP binding site [chemical binding]; other site 227882006590 Q-loop/lid; other site 227882006591 ABC transporter signature motif; other site 227882006592 Walker B; other site 227882006593 D-loop; other site 227882006594 H-loop/switch region; other site 227882006595 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 227882006596 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 227882006597 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 227882006598 Walker A/P-loop; other site 227882006599 ATP binding site [chemical binding]; other site 227882006600 Q-loop/lid; other site 227882006601 ABC transporter signature motif; other site 227882006602 Walker B; other site 227882006603 D-loop; other site 227882006604 H-loop/switch region; other site 227882006605 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 227882006606 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 227882006607 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882006608 Walker A/P-loop; other site 227882006609 ATP binding site [chemical binding]; other site 227882006610 Q-loop/lid; other site 227882006611 ABC transporter signature motif; other site 227882006612 Walker B; other site 227882006613 D-loop; other site 227882006614 H-loop/switch region; other site 227882006615 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 227882006616 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882006617 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 227882006618 Walker A/P-loop; other site 227882006619 ATP binding site [chemical binding]; other site 227882006620 Q-loop/lid; other site 227882006621 ABC transporter signature motif; other site 227882006622 Walker B; other site 227882006623 D-loop; other site 227882006624 H-loop/switch region; other site 227882006625 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 227882006626 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 227882006627 active site 227882006628 Zn binding site [ion binding]; other site 227882006629 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 227882006630 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 227882006631 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 227882006632 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 227882006633 active site 227882006634 Zn binding site [ion binding]; other site 227882006635 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 227882006636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 227882006637 non-specific DNA binding site [nucleotide binding]; other site 227882006638 salt bridge; other site 227882006639 sequence-specific DNA binding site [nucleotide binding]; other site 227882006640 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882006641 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 227882006642 putative homodimer interface [polypeptide binding]; other site 227882006643 putative active site pocket [active] 227882006644 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 227882006645 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 227882006646 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 227882006647 calcium binding site 2 [ion binding]; other site 227882006648 active site 227882006649 catalytic triad [active] 227882006650 calcium binding site 1 [ion binding]; other site 227882006651 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 227882006652 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 227882006653 trehalose synthase; Region: treS_nterm; TIGR02456 227882006654 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 227882006655 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 227882006656 glycogen branching enzyme; Provisional; Region: PRK05402 227882006657 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 227882006658 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 227882006659 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 227882006660 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 227882006661 Cytochrome P450; Region: p450; cl12078 227882006662 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 227882006663 UvrD/REP helicase; Region: UvrD-helicase; cl14126 227882006664 UvrD/REP helicase; Region: UvrD-helicase; cl14126 227882006665 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 227882006666 catalytic residues [active] 227882006667 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 227882006668 DNA binding residues [nucleotide binding] 227882006669 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 227882006670 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882006671 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882006672 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 227882006673 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 227882006674 putative NAD(P) binding site [chemical binding]; other site 227882006675 active site 227882006676 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded...; Region: proteasome_protease_HslV; cd01906 227882006677 active site 227882006678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882006679 putative substrate translocation pore; other site 227882006680 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 227882006681 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882006682 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 227882006683 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 227882006684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882006685 ATP binding site [chemical binding]; other site 227882006686 Mg2+ binding site [ion binding]; other site 227882006687 G-X-G motif; other site 227882006688 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 227882006689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882006690 active site 227882006691 phosphorylation site [posttranslational modification] 227882006692 intermolecular recognition site; other site 227882006693 dimerization interface [polypeptide binding]; other site 227882006694 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882006695 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882006696 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 227882006697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882006698 dimer interface [polypeptide binding]; other site 227882006699 conserved gate region; other site 227882006700 putative PBP binding loops; other site 227882006701 ABC-ATPase subunit interface; other site 227882006702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882006703 dimer interface [polypeptide binding]; other site 227882006704 conserved gate region; other site 227882006705 putative PBP binding loops; other site 227882006706 ABC-ATPase subunit interface; other site 227882006707 6-phosphofructokinase; Provisional; Region: PRK03202 227882006708 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cd00363 227882006709 active site 227882006710 ADP/pyrophosphate binding site [chemical binding]; other site 227882006711 dimerization interface [polypeptide binding]; other site 227882006712 allosteric effector site; other site 227882006713 fructose-1,6-bisphosphate binding site; other site 227882006714 phosphate acetyltransferase; Reviewed; Region: PRK05632 227882006715 DRTGG domain; Region: DRTGG; cl12147 227882006716 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 227882006717 Acetokinase family; Region: Acetate_kinase; cl01029 227882006718 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 227882006719 pyruvate kinase; Provisional; Region: PRK06247 227882006720 domain interfaces; other site 227882006721 active site 227882006722 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 227882006723 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 227882006724 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882006725 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 227882006726 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of methylmalonyl-; Region: MM_CoA_mutase; cl00817 227882006727 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 227882006728 Transcriptional regulators [Transcription]; Region: MarR; COG1846 227882006729 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882006730 FAD binding domain; Region: FAD_binding_3; pfam01494 227882006731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882006732 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882006733 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 227882006734 SchA/CurD like domain; Region: SchA_CurD; pfam04486 227882006735 SchA/CurD like domain; Region: SchA_CurD; pfam04486 227882006736 Cupin domain; Region: Cupin_2; cl09118 227882006737 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 227882006738 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 227882006739 dimer interface [polypeptide binding]; other site 227882006740 active site 227882006741 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 227882006742 Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier...; Region: CLF; cd00832 227882006743 active site 227882006744 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882006745 N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860 227882006746 putative hydrophobic ligand binding site [chemical binding]; other site 227882006747 active site 227882006748 catalytic residues_2 [active] 227882006749 catalytic residues_1 [active] 227882006750 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 227882006751 O-methyltransferase; Region: Methyltransf_2; pfam00891 227882006752 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 227882006753 Domain of unknown function DUF77; Region: DUF77; cl00307 227882006754 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 227882006755 Protein of unknown function DUF124; Region: DUF124; cl00884 227882006756 Protein of unknown function DUF124; Region: DUF124; cl00884 227882006757 Protein of unknown function DUF124; Region: DUF124; cl00884 227882006758 Transcriptional regulators [Transcription]; Region: MarR; COG1846 227882006759 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882006760 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 227882006761 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 227882006762 Walker A; other site 227882006763 putative acyltransferase; Provisional; Region: PRK05790 227882006764 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 227882006765 dimer interface [polypeptide binding]; other site 227882006766 active site 227882006767 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 227882006768 dimer interface [polypeptide binding]; other site 227882006769 substrate binding site [chemical binding]; other site 227882006770 metal binding site [ion binding]; metal-binding site 227882006771 MAEBL; Provisional; Region: PTZ00121 227882006772 phosphodiesterase; Provisional; Region: PRK12704 227882006773 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 227882006774 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 227882006775 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 227882006776 Walker A/P-loop; other site 227882006777 ATP binding site [chemical binding]; other site 227882006778 Q-loop/lid; other site 227882006779 ABC transporter signature motif; other site 227882006780 Walker B; other site 227882006781 D-loop; other site 227882006782 H-loop/switch region; other site 227882006783 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 227882006784 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 227882006785 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 227882006786 Walker A/P-loop; other site 227882006787 ATP binding site [chemical binding]; other site 227882006788 Q-loop/lid; other site 227882006789 ABC transporter signature motif; other site 227882006790 Walker B; other site 227882006791 D-loop; other site 227882006792 H-loop/switch region; other site 227882006793 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882006794 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 227882006795 Protein of unknown function DUF91; Region: DUF91; cl00709 227882006796 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 227882006797 anti sigma factor interaction site; other site 227882006798 regulatory phosphorylation site [posttranslational modification]; other site 227882006799 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 227882006800 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 227882006801 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 227882006802 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 227882006803 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882006804 PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 227882006805 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882006806 Walker A/P-loop; other site 227882006807 ATP binding site [chemical binding]; other site 227882006808 Q-loop/lid; other site 227882006809 ABC transporter signature motif; other site 227882006810 Walker B; other site 227882006811 D-loop; other site 227882006812 H-loop/switch region; other site 227882006813 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 227882006814 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 227882006815 Histidine kinase; Region: HisKA_3; pfam07730 227882006816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882006817 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882006818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882006819 active site 227882006820 phosphorylation site [posttranslational modification] 227882006821 intermolecular recognition site; other site 227882006822 dimerization interface [polypeptide binding]; other site 227882006823 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882006824 DNA binding residues [nucleotide binding] 227882006825 dimerization interface [polypeptide binding]; other site 227882006826 Cellulose binding domain; Region: CBM_2; cl02709 227882006827 Glyco_18 domain; Region: Glyco_18; smart00636 227882006828 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is...; Region: GH18_chitinase; cd06548 227882006829 active site 227882006830 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 227882006831 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 227882006832 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 227882006833 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 227882006834 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 227882006835 alpha subunit interaction interface [polypeptide binding]; other site 227882006836 Walker A motif; other site 227882006837 ATP binding site [chemical binding]; other site 227882006838 Walker B motif; other site 227882006839 inhibitor binding site; inhibition site 227882006840 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 227882006841 ATP synthase; Region: ATP-synt; cl00365 227882006842 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 227882006843 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 227882006844 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 227882006845 beta subunit interaction interface [polypeptide binding]; other site 227882006846 Walker A motif; other site 227882006847 ATP binding site [chemical binding]; other site 227882006848 Walker B motif; other site 227882006849 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 227882006850 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 227882006851 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 227882006852 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 227882006853 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 227882006854 ATP synthase subunit C; Region: ATP-synt_C; cl00466 227882006855 ATP synthase A chain; Region: ATP-synt_A; cl00413 227882006856 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 227882006857 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 227882006858 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 227882006859 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 227882006860 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 227882006861 NAD(P) binding site [chemical binding]; other site 227882006862 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882006863 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882006864 active site 227882006865 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882006866 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882006867 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882006868 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882006869 putative NADP binding site [chemical binding]; other site 227882006870 active site 227882006871 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882006872 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 227882006873 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882006874 active site 227882006875 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882006876 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882006877 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882006878 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 227882006879 Enoylreductase; Region: PKS_ER; smart00829 227882006880 NAD(P) binding site [chemical binding]; other site 227882006881 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882006882 putative NADP binding site [chemical binding]; other site 227882006883 active site 227882006884 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882006885 Erythronolide synthase docking; Region: Docking; pfam08990 227882006886 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 227882006887 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882006888 active site 227882006889 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882006890 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882006891 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882006892 putative NADP binding site [chemical binding]; other site 227882006893 active site 227882006894 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882006895 Cytochrome P450; Region: p450; cl12078 227882006896 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882006897 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882006898 active site 227882006899 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882006900 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882006901 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 227882006902 NADP binding site [chemical binding]; other site 227882006903 active site 227882006904 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882006905 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 227882006906 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882006907 active site 227882006908 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882006909 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882006910 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882006911 putative NADP binding site [chemical binding]; other site 227882006912 active site 227882006913 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882006914 Thioesterase; Region: PKS_TE; smart00824 227882006915 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882006916 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882006917 active site 227882006918 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882006919 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882006920 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 227882006921 NADP binding site [chemical binding]; other site 227882006922 active site 227882006923 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882006924 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882006925 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882006926 active site 227882006927 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882006928 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882006929 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 227882006930 NADP binding site [chemical binding]; other site 227882006931 active site 227882006932 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882006933 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882006934 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882006935 active site 227882006936 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882006937 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882006938 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 227882006939 NADP binding site [chemical binding]; other site 227882006940 active site 227882006941 acyl-CoA synthetase; Validated; Region: PRK06060 227882006942 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882006943 Erythronolide synthase docking; Region: Docking; pfam08990 227882006944 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 227882006945 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882006946 active site 227882006947 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882006948 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882006949 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882006950 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 227882006951 Enoylreductase; Region: PKS_ER; smart00829 227882006952 NAD(P) binding site [chemical binding]; other site 227882006953 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882006954 putative NADP binding site [chemical binding]; other site 227882006955 active site 227882006956 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882006957 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 227882006958 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882006959 active site 227882006960 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882006961 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882006962 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882006963 putative NADP binding site [chemical binding]; other site 227882006964 active site 227882006965 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882006966 Erythronolide synthase docking; Region: Docking; pfam08990 227882006967 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882006968 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882006969 active site 227882006970 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882006971 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882006972 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 227882006973 NADP binding site [chemical binding]; other site 227882006974 active site 227882006975 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882006976 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882006977 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882006978 active site 227882006979 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882006980 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882006981 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 227882006982 NADP binding site [chemical binding]; other site 227882006983 active site 227882006984 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882006985 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882006986 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882006987 active site 227882006988 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882006989 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882006990 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882006991 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882006992 putative NADP binding site [chemical binding]; other site 227882006993 active site 227882006994 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882006995 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882006996 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882006997 active site 227882006998 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882006999 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882007000 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882007001 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882007002 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882007003 active site 227882007004 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882007005 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882007006 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 227882007007 NADP binding site [chemical binding]; other site 227882007008 active site 227882007009 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882007010 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882007011 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 227882007012 active site 227882007013 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882007014 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882007015 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 227882007016 NADP binding site [chemical binding]; other site 227882007017 active site 227882007018 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882007019 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 227882007020 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882007021 active site 227882007022 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882007023 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 227882007024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882007025 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 227882007026 Enoylreductase; Region: PKS_ER; smart00829 227882007027 NAD(P) binding site [chemical binding]; other site 227882007028 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 227882007029 putative NADP binding site [chemical binding]; other site 227882007030 active site 227882007031 acyl-CoA synthetase; Validated; Region: PRK06060 227882007032 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882007033 Cytochrome P450; Region: p450; cl12078 227882007034 Predicted ATPase [General function prediction only]; Region: COG3899 227882007035 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882007036 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882007037 DNA binding residues [nucleotide binding] 227882007038 dimerization interface [polypeptide binding]; other site 227882007039 Predicted ATPase [General function prediction only]; Region: COG3899 227882007040 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 227882007041 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882007042 DNA binding residues [nucleotide binding] 227882007043 dimerization interface [polypeptide binding]; other site 227882007044 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 227882007045 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882007046 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 227882007047 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 227882007048 active site 227882007049 metal binding site [ion binding]; metal-binding site 227882007050 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 227882007051 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of methylmalonyl-; Region: MM_CoA_mutase; cl00817 227882007052 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 227882007053 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 227882007054 Mg++ binding site [ion binding]; other site 227882007055 putative catalytic motif [active] 227882007056 substrate binding site [chemical binding]; other site 227882007057 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 227882007058 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 227882007059 dimer interface [polypeptide binding]; other site 227882007060 glycine-pyridoxal phosphate binding site [chemical binding]; other site 227882007061 active site 227882007062 folate binding site [chemical binding]; other site 227882007063 Low molecular weight phosphatase family; Region: LMWPc; cl00105 227882007064 Active site [active] 227882007065 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 227882007066 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 227882007067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882007068 S-adenosylmethionine binding site [chemical binding]; other site 227882007069 peptide chain release factor 1; Validated; Region: prfA; PRK00591 227882007070 RF-1 domain; Region: RF-1; cl02875 227882007071 RF-1 domain; Region: RF-1; cl02875 227882007072 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 227882007073 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 227882007074 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 227882007075 transcription termination factor Rho; Provisional; Region: PRK12608 227882007076 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 227882007077 RNA binding site [nucleotide binding]; other site 227882007078 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 227882007079 multimer interface [polypeptide binding]; other site 227882007080 Walker A motif; other site 227882007081 ATP binding site [chemical binding]; other site 227882007082 Walker B motif; other site 227882007083 homoserine kinase; Provisional; Region: PRK01212 227882007084 threonine synthase; Reviewed; Region: PRK06721 227882007085 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 227882007086 homodimer interface [polypeptide binding]; other site 227882007087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882007088 catalytic residue [active] 227882007089 homoserine dehydrogenase; Provisional; Region: PRK06349 227882007090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882007091 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 227882007092 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 227882007093 diaminopimelate decarboxylase; Region: lysA; TIGR01048 227882007094 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 227882007095 active site 227882007096 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 227882007097 substrate binding site [chemical binding]; other site 227882007098 catalytic residues [active] 227882007099 dimer interface [polypeptide binding]; other site 227882007100 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 227882007101 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 227882007102 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 227882007103 Response regulator receiver domain; Region: Response_reg; pfam00072 227882007104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882007105 active site 227882007106 phosphorylation site [posttranslational modification] 227882007107 intermolecular recognition site; other site 227882007108 dimerization interface [polypeptide binding]; other site 227882007109 FG-GAP repeat; Region: FG-GAP; cl15299 227882007110 FG-GAP repeat; Region: FG-GAP; cl15299 227882007111 FG-GAP repeat; Region: FG-GAP; cl15299 227882007112 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 227882007113 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882007114 Walker A/P-loop; other site 227882007115 ATP binding site [chemical binding]; other site 227882007116 Golgi-body localisation protein domain; Region: Apt1; pfam10351 227882007117 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179 227882007118 putative active site [active] 227882007119 catalytic site [active] 227882007120 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 227882007121 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 227882007122 ATP binding site [chemical binding]; other site 227882007123 putative Mg++ binding site [ion binding]; other site 227882007124 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 227882007125 nucleotide binding region [chemical binding]; other site 227882007126 ATP-binding site [chemical binding]; other site 227882007127 Domain of unknown function (DUF1832); Region: DUF1832; cl07463 227882007128 DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185 227882007129 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882007130 Walker A/P-loop; other site 227882007131 ATP binding site [chemical binding]; other site 227882007132 Q-loop/lid; other site 227882007133 ABC transporter signature motif; other site 227882007134 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882007135 ABC transporter signature motif; other site 227882007136 Walker B; other site 227882007137 D-loop; other site 227882007138 H-loop/switch region; other site 227882007139 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 227882007140 Active Sites [active] 227882007141 DGQHR domain; Region: DGQHR; cl14002 227882007142 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 227882007143 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882007144 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 227882007145 catalytic residue [active] 227882007146 DNA phosphorothioation-associated putative methyltransferase; Region: dnd_rel_methyl; TIGR04096 227882007147 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 227882007148 DNA binding site [nucleotide binding] 227882007149 Int/Topo IB signature motif; other site 227882007150 active site 227882007151 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 227882007152 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 227882007153 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 227882007154 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 227882007155 dimer interface [polypeptide binding]; other site 227882007156 active site 227882007157 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 227882007158 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 227882007159 putative DNA binding site [nucleotide binding]; other site 227882007160 putative homodimer interface [polypeptide binding]; other site 227882007161 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for non-...; Region: MtLigD_Pol_like; cd04863 227882007162 nucleotide binding site [chemical binding]; other site 227882007163 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr (; Region: PTPc; cl00053 227882007164 active site 227882007165 catalytic residues [active] 227882007166 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 227882007167 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882007168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 227882007169 dimer interface [polypeptide binding]; other site 227882007170 phosphorylation site [posttranslational modification] 227882007171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882007172 ATP binding site [chemical binding]; other site 227882007173 Mg2+ binding site [ion binding]; other site 227882007174 G-X-G motif; other site 227882007175 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 227882007176 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 227882007177 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 227882007178 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 227882007179 dinuclear metal binding motif [ion binding]; other site 227882007180 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 227882007181 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882007182 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882007183 adhesin; Provisional; Region: PRK09752 227882007184 NlpC/P60 family; Region: NLPC_P60; cl11438 227882007185 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 227882007186 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 227882007187 G1 box; other site 227882007188 GTP/Mg2+ binding site [chemical binding]; other site 227882007189 G2 box; other site 227882007190 Switch I region; other site 227882007191 G3 box; other site 227882007192 Switch II region; other site 227882007193 G4 box; other site 227882007194 G5 box; other site 227882007195 Protein of unknown function (DUF742); Region: DUF742; pfam05331 227882007196 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 227882007197 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882007198 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 227882007199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882007200 ATP binding site [chemical binding]; other site 227882007201 Mg2+ binding site [ion binding]; other site 227882007202 G-X-G motif; other site 227882007203 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882007204 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme (; Region: GH25_CH-type; cd06412 227882007205 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 227882007206 active site 227882007207 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 227882007208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882007209 ATP binding site [chemical binding]; other site 227882007210 Walker A motif; other site 227882007211 Walker B motif; other site 227882007212 arginine finger; other site 227882007213 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 227882007214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882007215 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 227882007216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882007217 active site 227882007218 phosphorylation site [posttranslational modification] 227882007219 intermolecular recognition site; other site 227882007220 dimerization interface [polypeptide binding]; other site 227882007221 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882007222 DNA binding site [nucleotide binding] 227882007223 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 227882007224 dimerization interface [polypeptide binding]; other site 227882007225 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 227882007226 dimer interface [polypeptide binding]; other site 227882007227 phosphorylation site [posttranslational modification] 227882007228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882007229 ATP binding site [chemical binding]; other site 227882007230 Mg2+ binding site [ion binding]; other site 227882007231 G-X-G motif; other site 227882007232 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 227882007233 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 227882007234 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 227882007235 TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl-CoA and carbon dioxide, a key reaction of...; Region: TPP_E1_OGDC_like; cd02016 227882007236 TPP-binding site [chemical binding]; other site 227882007237 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 227882007238 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 227882007239 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882007240 Uncharacterized conserved protein [Function unknown]; Region: COG3595 227882007241 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882007242 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882007243 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 227882007244 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 227882007245 NAD(P) binding site [chemical binding]; other site 227882007246 Malic enzyme, N-terminal domain; Region: malic; pfam00390 227882007247 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882007248 NAD(P) binding pocket [chemical binding]; other site 227882007249 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 227882007250 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 227882007251 substrate binding pocket [chemical binding]; other site 227882007252 membrane-bound complex binding site; other site 227882007253 hinge residues; other site 227882007254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882007255 dimer interface [polypeptide binding]; other site 227882007256 conserved gate region; other site 227882007257 putative PBP binding loops; other site 227882007258 ABC-ATPase subunit interface; other site 227882007259 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 227882007260 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 227882007261 Walker A/P-loop; other site 227882007262 ATP binding site [chemical binding]; other site 227882007263 Q-loop/lid; other site 227882007264 ABC transporter signature motif; other site 227882007265 Walker B; other site 227882007266 D-loop; other site 227882007267 H-loop/switch region; other site 227882007268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882007269 S-adenosylmethionine binding site [chemical binding]; other site 227882007270 CGNR zinc finger; Region: zf-CGNR; pfam11706 227882007271 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 227882007272 Catalytic site [active] 227882007273 Nickel-containing superoxide dismutase; Region: Sod_Ni; cl07609 227882007274 Transcriptional regulators [Transcription]; Region: MarR; COG1846 227882007275 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882007276 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 227882007277 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 227882007278 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 227882007279 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 227882007280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882007281 putative substrate translocation pore; other site 227882007282 hypothetical protein; Provisional; Region: PRK06194 227882007283 classical (c) SDRs; Region: SDR_c; cd05233 227882007284 NAD(P) binding site [chemical binding]; other site 227882007285 active site 227882007286 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 227882007287 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 227882007288 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 227882007289 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 227882007290 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 227882007291 substrate binding pocket [chemical binding]; other site 227882007292 chain length determination region; other site 227882007293 substrate-Mg2+ binding site; other site 227882007294 catalytic residues [active] 227882007295 aspartate-rich region 1; other site 227882007296 active site lid residues [active] 227882007297 aspartate-rich region 2; other site 227882007298 Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687 227882007299 substrate binding pocket [chemical binding]; other site 227882007300 substrate-Mg2+ binding site; other site 227882007301 aspartate-rich region 1; other site 227882007302 active site lid residues [active] 227882007303 aspartate-rich region 2; other site 227882007304 Cytochrome P450; Region: p450; cl12078 227882007305 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 227882007306 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882007307 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 227882007308 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 227882007309 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 227882007310 Protein of unknown function (DUF952); Region: DUF952; cl01393 227882007311 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882007312 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 227882007313 substrate binding pocket [chemical binding]; other site 227882007314 chain length determination region; other site 227882007315 substrate-Mg2+ binding site; other site 227882007316 catalytic residues [active] 227882007317 aspartate-rich region 1; other site 227882007318 active site lid residues [active] 227882007319 aspartate-rich region 2; other site 227882007320 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 227882007321 ligand binding site [chemical binding]; other site 227882007322 flexible hinge region; other site 227882007323 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 227882007324 amidase catalytic site [active] 227882007325 Zn binding residues [ion binding]; other site 227882007326 substrate binding site [chemical binding]; other site 227882007327 1-aminocyclopropane-1-carboxylate deaminase [Amino acid transport and metabolism]; Region: Acd; COG2515 227882007328 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cl00342 227882007329 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 227882007330 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957 227882007331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882007332 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 227882007333 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882007334 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 227882007335 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882007336 DNA binding residues [nucleotide binding] 227882007337 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 227882007338 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 227882007339 Transcription factor WhiB; Region: Whib; pfam02467 227882007340 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 227882007341 Histidine kinase; Region: HisKA_2; cl06527 227882007342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882007343 ATP binding site [chemical binding]; other site 227882007344 Mg2+ binding site [ion binding]; other site 227882007345 G-X-G motif; other site 227882007346 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 227882007347 active site 227882007348 trimer interface [polypeptide binding]; other site 227882007349 allosteric site; other site 227882007350 active site lid [active] 227882007351 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 227882007352 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 227882007353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882007354 dimer interface [polypeptide binding]; other site 227882007355 conserved gate region; other site 227882007356 putative PBP binding loops; other site 227882007357 ABC-ATPase subunit interface; other site 227882007358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882007359 dimer interface [polypeptide binding]; other site 227882007360 conserved gate region; other site 227882007361 putative PBP binding loops; other site 227882007362 ABC-ATPase subunit interface; other site 227882007363 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 227882007364 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882007365 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 227882007366 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882007367 DNA-binding site [nucleotide binding]; DNA binding site 227882007368 UTRA domain; Region: UTRA; cl01230 227882007369 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 227882007370 Sodium:solute symporter family; Region: SSF; cl00456 227882007371 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 227882007372 Class I ribonucleotide reductase; Region: RNR_I; cd01679 227882007373 active site 227882007374 dimer interface [polypeptide binding]; other site 227882007375 catalytic residues [active] 227882007376 effector binding site; other site 227882007377 R2 peptide binding site; other site 227882007378 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 227882007379 dimer interface [polypeptide binding]; other site 227882007380 putative radical transfer pathway; other site 227882007381 diiron center [ion binding]; other site 227882007382 tyrosyl radical; other site 227882007383 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12901 227882007384 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 227882007385 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 227882007386 conserved cys residue [active] 227882007387 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882007388 Cytochrome P450; Region: p450; cl12078 227882007389 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 227882007390 substrate binding pocket [chemical binding]; other site 227882007391 substrate-Mg2+ binding site; other site 227882007392 aspartate-rich region 1; other site 227882007393 aspartate-rich region 2; other site 227882007394 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 227882007395 active site 227882007396 catalytic residues [active] 227882007397 metal binding site [ion binding]; metal-binding site 227882007398 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 227882007399 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 227882007400 Zn2+ binding site [ion binding]; other site 227882007401 Mg2+ binding site [ion binding]; other site 227882007402 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl11829 227882007403 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 227882007404 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882007405 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882007406 DNA binding residues [nucleotide binding] 227882007407 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 227882007408 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 227882007409 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 227882007410 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 227882007411 hinge; other site 227882007412 active site 227882007413 Predicted GTPases [General function prediction only]; Region: COG1162 227882007414 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 227882007415 GTPase/OB domain interface [polypeptide binding]; other site 227882007416 GTPase/Zn-binding domain interface [polypeptide binding]; other site 227882007417 GTP/Mg2+ binding site [chemical binding]; other site 227882007418 G4 box; other site 227882007419 G5 box; other site 227882007420 G1 box; other site 227882007421 Switch I region; other site 227882007422 G2 box; other site 227882007423 G3 box; other site 227882007424 Switch II region; other site 227882007425 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 227882007426 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 227882007427 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 227882007428 Walker A/P-loop; other site 227882007429 ATP binding site [chemical binding]; other site 227882007430 Q-loop/lid; other site 227882007431 ABC transporter signature motif; other site 227882007432 Walker B; other site 227882007433 D-loop; other site 227882007434 H-loop/switch region; other site 227882007435 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 227882007436 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 227882007437 Walker A/P-loop; other site 227882007438 ATP binding site [chemical binding]; other site 227882007439 Q-loop/lid; other site 227882007440 ABC transporter signature motif; other site 227882007441 Walker B; other site 227882007442 D-loop; other site 227882007443 H-loop/switch region; other site 227882007444 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 227882007445 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 227882007446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882007447 dimer interface [polypeptide binding]; other site 227882007448 conserved gate region; other site 227882007449 putative PBP binding loops; other site 227882007450 ABC-ATPase subunit interface; other site 227882007451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882007452 dimer interface [polypeptide binding]; other site 227882007453 conserved gate region; other site 227882007454 putative PBP binding loops; other site 227882007455 ABC-ATPase subunit interface; other site 227882007456 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 227882007457 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 227882007458 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882007459 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882007460 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 227882007461 active site 227882007462 FOG: CBS domain [General function prediction only]; Region: COG0517 227882007463 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_11; cd04624 227882007464 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 227882007465 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 227882007466 tetramer interface [polypeptide binding]; other site 227882007467 heme binding pocket [chemical binding]; other site 227882007468 NADPH binding site [chemical binding]; other site 227882007469 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 227882007470 metal binding site 2 [ion binding]; metal-binding site 227882007471 putative DNA binding helix; other site 227882007472 metal binding site 1 [ion binding]; metal-binding site 227882007473 dimer interface [polypeptide binding]; other site 227882007474 structural Zn2+ binding site [ion binding]; other site 227882007475 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 227882007476 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 227882007477 Uncharacterised protein family (UPF0182); Region: UPF0182; pfam03699 227882007478 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 227882007479 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 227882007480 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 227882007481 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 227882007482 MoaE homodimer interface [polypeptide binding]; other site 227882007483 MoaD interaction [polypeptide binding]; other site 227882007484 active site residues [active] 227882007485 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 227882007486 putative NAD(P) binding site [chemical binding]; other site 227882007487 active site 227882007488 putative substrate binding site [chemical binding]; other site 227882007489 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 227882007490 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 227882007491 nudix motif; other site 227882007492 Protein of unknown function DUF124; Region: DUF124; cl00884 227882007493 Protein of unknown function DUF124; Region: DUF124; cl00884 227882007494 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 227882007495 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 227882007496 putative metal binding site [ion binding]; other site 227882007497 Protein of unknown function DUF124; Region: DUF124; cl00884 227882007498 Protein of unknown function DUF45; Region: DUF45; cl00636 227882007499 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 227882007500 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882007501 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882007502 active site 227882007503 ATP binding site [chemical binding]; other site 227882007504 Transcription factor WhiB; Region: Whib; pfam02467 227882007505 UvrD/REP helicase; Region: UvrD-helicase; cl14126 227882007506 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 227882007507 HRDC domain; Region: HRDC; cl02578 227882007508 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 227882007509 catalytic residues [active] 227882007510 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 227882007511 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 227882007512 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 227882007513 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 227882007514 putative NADH binding site [chemical binding]; other site 227882007515 putative active site [active] 227882007516 nudix motif; other site 227882007517 putative metal binding site [ion binding]; other site 227882007518 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 227882007519 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 227882007520 metal binding site [ion binding]; metal-binding site 227882007521 putative dimer interface [polypeptide binding]; other site 227882007522 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 227882007523 UvrD/REP helicase; Region: UvrD-helicase; cl14126 227882007524 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 227882007525 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 227882007526 UvrD/REP helicase; Region: UvrD-helicase; cl14126 227882007527 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 227882007528 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 227882007529 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 227882007530 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 227882007531 active site 227882007532 DNA binding site [nucleotide binding] 227882007533 Predicted integral membrane protein [Function unknown]; Region: COG0392 227882007534 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 227882007535 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 227882007536 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882007537 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 227882007538 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882007539 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 227882007540 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 227882007541 ATP binding site [chemical binding]; other site 227882007542 substrate interface [chemical binding]; other site 227882007543 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 227882007544 active site residue [active] 227882007545 Spherulation-specific family 4; Region: Spherulin4; pfam12138 227882007546 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 227882007547 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882007548 NAD(P) binding site [chemical binding]; other site 227882007549 active site 227882007550 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 227882007551 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 227882007552 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 227882007553 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 227882007554 Walker A/P-loop; other site 227882007555 ATP binding site [chemical binding]; other site 227882007556 Q-loop/lid; other site 227882007557 ABC transporter signature motif; other site 227882007558 Walker B; other site 227882007559 D-loop; other site 227882007560 H-loop/switch region; other site 227882007561 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 227882007562 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 227882007563 Walker A/P-loop; other site 227882007564 ATP binding site [chemical binding]; other site 227882007565 Q-loop/lid; other site 227882007566 ABC transporter signature motif; other site 227882007567 Walker B; other site 227882007568 D-loop; other site 227882007569 H-loop/switch region; other site 227882007570 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 227882007571 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 227882007572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882007573 dimer interface [polypeptide binding]; other site 227882007574 conserved gate region; other site 227882007575 putative PBP binding loops; other site 227882007576 ABC-ATPase subunit interface; other site 227882007577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882007578 dimer interface [polypeptide binding]; other site 227882007579 conserved gate region; other site 227882007580 putative PBP binding loops; other site 227882007581 ABC-ATPase subunit interface; other site 227882007582 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 227882007583 peptide binding site [polypeptide binding]; other site 227882007584 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 227882007585 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 227882007586 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882007587 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882007588 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882007589 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882007590 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882007591 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 227882007592 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 227882007593 dinuclear metal binding motif [ion binding]; other site 227882007594 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882007595 ATP binding site [chemical binding]; other site 227882007596 putative Mg++ binding site [ion binding]; other site 227882007597 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 227882007598 nucleotide binding region [chemical binding]; other site 227882007599 ATP-binding site [chemical binding]; other site 227882007600 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882007601 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 227882007602 putative metal binding site [ion binding]; other site 227882007603 MarC family integral membrane protein; Region: MarC; cl00919 227882007604 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 227882007605 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 227882007606 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 227882007607 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 227882007608 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 227882007609 MgtE intracellular N domain; Region: MgtE_N; cl15244 227882007610 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 227882007611 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 227882007612 Domain of unknown function DUF59; Region: DUF59; cl00941 227882007613 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 227882007614 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 227882007615 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 227882007616 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 227882007617 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 227882007618 protein binding site [polypeptide binding]; other site 227882007619 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl11829 227882007620 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 227882007621 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882007622 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882007623 DNA binding residues [nucleotide binding] 227882007624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882007625 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 227882007626 enoyl-CoA hydratase; Provisional; Region: PRK08140 227882007627 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 227882007628 substrate binding site [chemical binding]; other site 227882007629 oxyanion hole (OAH) forming residues; other site 227882007630 trimer interface [polypeptide binding]; other site 227882007631 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 227882007632 DivIVA domain; Region: DivI1A_domain; TIGR03544 227882007633 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 227882007634 dihydropteroate synthase; Region: DHPS; TIGR01496 227882007635 substrate binding pocket [chemical binding]; other site 227882007636 dimer interface [polypeptide binding]; other site 227882007637 inhibitor binding site; inhibition site 227882007638 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 227882007639 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 227882007640 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 227882007641 metal binding site [ion binding]; metal-binding site 227882007642 putative dimer interface [polypeptide binding]; other site 227882007643 aspartate aminotransferase; Provisional; Region: PRK07681 227882007644 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 227882007645 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882007646 homodimer interface [polypeptide binding]; other site 227882007647 catalytic residue [active] 227882007648 Ferredoxin [Energy production and conversion]; Region: COG1146 227882007649 4Fe-4S binding domain; Region: Fer4; cl02805 227882007650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882007651 hypothetical protein; Provisional; Region: PRK10941 227882007652 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882007653 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882007654 active site 227882007655 phosphorylation site [posttranslational modification] 227882007656 intermolecular recognition site; other site 227882007657 dimerization interface [polypeptide binding]; other site 227882007658 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882007659 DNA binding residues [nucleotide binding] 227882007660 dimerization interface [polypeptide binding]; other site 227882007661 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 227882007662 Histidine kinase; Region: HisKA_3; pfam07730 227882007663 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 227882007664 ABC-2 type transporter; Region: ABC2_membrane; cl11417 227882007665 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 227882007666 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 227882007667 Walker A/P-loop; other site 227882007668 ATP binding site [chemical binding]; other site 227882007669 Q-loop/lid; other site 227882007670 ABC transporter signature motif; other site 227882007671 Walker B; other site 227882007672 D-loop; other site 227882007673 H-loop/switch region; other site 227882007674 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 227882007675 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 227882007676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882007677 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882007678 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882007679 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 227882007680 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882007681 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 227882007682 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 227882007683 Walker A/P-loop; other site 227882007684 ATP binding site [chemical binding]; other site 227882007685 Q-loop/lid; other site 227882007686 ABC transporter signature motif; other site 227882007687 Walker B; other site 227882007688 D-loop; other site 227882007689 H-loop/switch region; other site 227882007690 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 227882007691 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 227882007692 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 227882007693 Walker A/P-loop; other site 227882007694 ATP binding site [chemical binding]; other site 227882007695 Q-loop/lid; other site 227882007696 ABC transporter signature motif; other site 227882007697 Walker B; other site 227882007698 D-loop; other site 227882007699 H-loop/switch region; other site 227882007700 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 227882007701 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 227882007702 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 227882007703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 227882007704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882007705 dimer interface [polypeptide binding]; other site 227882007706 conserved gate region; other site 227882007707 putative PBP binding loops; other site 227882007708 ABC-ATPase subunit interface; other site 227882007709 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 227882007710 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 227882007711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882007712 dimer interface [polypeptide binding]; other site 227882007713 conserved gate region; other site 227882007714 putative PBP binding loops; other site 227882007715 ABC-ATPase subunit interface; other site 227882007716 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 227882007717 peptide binding site [polypeptide binding]; other site 227882007718 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 227882007719 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 227882007720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882007721 dimer interface [polypeptide binding]; other site 227882007722 ABC-ATPase subunit interface; other site 227882007723 putative PBP binding loops; other site 227882007724 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 227882007725 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 227882007726 Walker A/P-loop; other site 227882007727 ATP binding site [chemical binding]; other site 227882007728 Q-loop/lid; other site 227882007729 ABC transporter signature motif; other site 227882007730 Walker B; other site 227882007731 D-loop; other site 227882007732 H-loop/switch region; other site 227882007733 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 227882007734 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 227882007735 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 227882007736 Walker A/P-loop; other site 227882007737 ATP binding site [chemical binding]; other site 227882007738 Q-loop/lid; other site 227882007739 ABC transporter signature motif; other site 227882007740 Walker B; other site 227882007741 D-loop; other site 227882007742 H-loop/switch region; other site 227882007743 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 227882007744 MbtH-like protein; Region: MbtH; cl01279 227882007745 AMP-binding domain protein; Validated; Region: PRK08315 227882007746 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 227882007747 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882007748 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882007749 H+ Antiporter protein; Region: 2A0121; TIGR00900 227882007750 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 227882007751 Condensation domain; Region: Condensation; cl09290 227882007752 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 227882007753 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882007754 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882007755 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 227882007756 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882007757 homodimer interface [polypeptide binding]; other site 227882007758 catalytic residue [active] 227882007759 diaminopimelate epimerase; Provisional; Region: PRK13577 227882007760 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 227882007761 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 227882007762 Uncharacterized protein conserved in bacteria (DUF2257); Region: DUF2257; cl01794 227882007763 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882007764 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 227882007765 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 227882007766 conserved cys residue [active] 227882007767 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882007768 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882007769 Cupin domain; Region: Cupin_2; cl09118 227882007770 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 227882007771 DinB superfamily; Region: DinB_2; cl00986 227882007772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882007773 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 227882007774 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 227882007775 Walker A/P-loop; other site 227882007776 ATP binding site [chemical binding]; other site 227882007777 Q-loop/lid; other site 227882007778 ABC transporter signature motif; other site 227882007779 Walker B; other site 227882007780 D-loop; other site 227882007781 H-loop/switch region; other site 227882007782 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 227882007783 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 227882007784 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 227882007785 Walker A/P-loop; other site 227882007786 ATP binding site [chemical binding]; other site 227882007787 Q-loop/lid; other site 227882007788 ABC transporter signature motif; other site 227882007789 Walker B; other site 227882007790 D-loop; other site 227882007791 H-loop/switch region; other site 227882007792 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 227882007793 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 227882007794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882007795 dimer interface [polypeptide binding]; other site 227882007796 conserved gate region; other site 227882007797 putative PBP binding loops; other site 227882007798 ABC-ATPase subunit interface; other site 227882007799 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 227882007800 peptide binding site [polypeptide binding]; other site 227882007801 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 227882007802 rod shape-determining protein Mbl; Provisional; Region: PRK13928 227882007803 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 227882007804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882007805 dimer interface [polypeptide binding]; other site 227882007806 conserved gate region; other site 227882007807 putative PBP binding loops; other site 227882007808 ABC-ATPase subunit interface; other site 227882007809 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 227882007810 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 227882007811 G1 box; other site 227882007812 putative GEF interaction site [polypeptide binding]; other site 227882007813 GTP/Mg2+ binding site [chemical binding]; other site 227882007814 Switch I region; other site 227882007815 G2 box; other site 227882007816 G3 box; other site 227882007817 Switch II region; other site 227882007818 G4 box; other site 227882007819 G5 box; other site 227882007820 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 227882007821 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 227882007822 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 227882007823 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 227882007824 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 227882007825 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 227882007826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882007827 domain; Region: Succ_DH_flav_C; pfam02910 227882007828 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 227882007829 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 227882007830 active site 227882007831 PAS domain S-box; Region: sensory_box; TIGR00229 227882007832 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 227882007833 putative active site [active] 227882007834 heme pocket [chemical binding]; other site 227882007835 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 227882007836 PAS fold; Region: PAS_4; pfam08448 227882007837 GAF domain; Region: GAF; cl00853 227882007838 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882007839 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882007840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882007841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882007842 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 227882007843 active site 227882007844 8-oxo-dGMP binding site [chemical binding]; other site 227882007845 nudix motif; other site 227882007846 metal binding site [ion binding]; metal-binding site 227882007847 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 227882007848 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882007849 DNA-binding site [nucleotide binding]; DNA binding site 227882007850 UTRA domain; Region: UTRA; cl01230 227882007851 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 227882007852 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 227882007853 homodimer interface [polypeptide binding]; other site 227882007854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882007855 catalytic residue [active] 227882007856 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 227882007857 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 227882007858 ATP binding site [chemical binding]; other site 227882007859 putative Mg++ binding site [ion binding]; other site 227882007860 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 227882007861 nucleotide binding region [chemical binding]; other site 227882007862 ATP-binding site [chemical binding]; other site 227882007863 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 227882007864 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 227882007865 Predicted amidohydrolase [General function prediction only]; Region: COG0388 227882007866 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 227882007867 active site 227882007868 catalytic triad [active] 227882007869 dimer interface [polypeptide binding]; other site 227882007870 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 227882007871 AzlC protein; Region: AzlC; cl00570 227882007872 peptide synthase; Provisional; Region: PRK12467 227882007873 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882007874 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 227882007875 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882007876 Condensation domain; Region: Condensation; cl09290 227882007877 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 227882007878 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 227882007879 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882007880 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 227882007881 peptide synthase; Provisional; Region: PRK12467 227882007882 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882007883 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882007884 Condensation domain; Region: Condensation; cl09290 227882007885 peptide synthase; Provisional; Region: PRK12467 227882007886 acyl-CoA synthetase; Validated; Region: PRK07868 227882007887 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882007888 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 227882007889 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882007890 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 227882007891 classical (c) SDRs; Region: SDR_c; cd05233 227882007892 NAD(P) binding site [chemical binding]; other site 227882007893 active site 227882007894 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 227882007895 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 227882007896 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882007897 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 227882007898 Phd_YefM; Region: PhdYeFM; cl09153 227882007899 GTP-binding protein YchF; Reviewed; Region: PRK09601 227882007900 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 227882007901 G1 box; other site 227882007902 GTP/Mg2+ binding site [chemical binding]; other site 227882007903 Switch I region; other site 227882007904 G2 box; other site 227882007905 Switch II region; other site 227882007906 G3 box; other site 227882007907 G4 box; other site 227882007908 G5 box; other site 227882007909 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 227882007910 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 227882007911 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882007912 LytB protein; Region: LYTB; cl00507 227882007913 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 227882007914 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 227882007915 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 227882007916 generic binding surface II; other site 227882007917 generic binding surface I; other site 227882007918 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 227882007919 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 227882007920 putative FMN binding site [chemical binding]; other site 227882007921 Fructose-1,6-bisphosphatase/sedoheptulose 1,7-bisphosphatase and related proteins [Carbohydrate transport and metabolism]; Region: GlpX; COG1494 227882007922 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 227882007923 putative active site [active] 227882007924 Transcription factor WhiB; Region: Whib; pfam02467 227882007925 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 227882007926 Predicted membrane protein (DUF2154); Region: DUF2154; cl12089 227882007927 fumarate hydratase; Provisional; Region: PRK15389 227882007928 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 227882007929 Fumarase C-terminus; Region: Fumerase_C; cl00795 227882007930 fumarate hydratase; Reviewed; Region: fumC; PRK00485 227882007931 Class II fumarases; Region: Fumarase_classII; cd01362 227882007932 active site 227882007933 tetramer interface [polypeptide binding]; other site 227882007934 Protein of unknown function (DUF402); Region: DUF402; cl00979 227882007935 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882007936 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882007937 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882007938 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 227882007939 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 227882007940 tetramer interface [polypeptide binding]; other site 227882007941 heme binding pocket [chemical binding]; other site 227882007942 NADPH binding site [chemical binding]; other site 227882007943 Transglycosylase; Region: Transgly; cl07896 227882007944 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 227882007945 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 227882007946 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 227882007947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 227882007948 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882007949 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 227882007950 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 227882007951 Walker A/P-loop; other site 227882007952 ATP binding site [chemical binding]; other site 227882007953 Q-loop/lid; other site 227882007954 ABC transporter signature motif; other site 227882007955 Walker B; other site 227882007956 D-loop; other site 227882007957 H-loop/switch region; other site 227882007958 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882007959 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 227882007960 dimerization interface [polypeptide binding]; other site 227882007961 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 227882007962 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 227882007963 dimer interface [polypeptide binding]; other site 227882007964 decamer (pentamer of dimers) interface [polypeptide binding]; other site 227882007965 catalytic triad [active] 227882007966 peroxidatic and resolving cysteines [active] 227882007967 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 227882007968 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 227882007969 Domain of unknown function DUF20; Region: UPF0118; cl00465 227882007970 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 227882007971 N-acetyl-D-glucosamine binding site [chemical binding]; other site 227882007972 catalytic residue [active] 227882007973 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 227882007974 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 227882007975 putative active site [active] 227882007976 PhoH-like protein; Region: PhoH; cl12134 227882007977 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 227882007978 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 227882007979 catalytic residue [active] 227882007980 putative FPP diphosphate binding site; other site 227882007981 putative FPP binding hydrophobic cleft; other site 227882007982 dimer interface [polypeptide binding]; other site 227882007983 putative IPP diphosphate binding site; other site 227882007984 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 227882007985 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 227882007986 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882007987 DinB superfamily; Region: DinB_2; cl00986 227882007988 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882007989 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 227882007990 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 227882007991 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 227882007992 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 227882007993 ligand binding site [chemical binding]; other site 227882007994 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882007995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882007996 active site 227882007997 phosphorylation site [posttranslational modification] 227882007998 intermolecular recognition site; other site 227882007999 dimerization interface [polypeptide binding]; other site 227882008000 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882008001 DNA binding residues [nucleotide binding] 227882008002 dimerization interface [polypeptide binding]; other site 227882008003 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 227882008004 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882008005 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 227882008006 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 227882008007 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 227882008008 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 227882008009 ATP binding site [chemical binding]; other site 227882008010 Walker A motif; other site 227882008011 hexamer interface [polypeptide binding]; other site 227882008012 Walker B motif; other site 227882008013 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882008014 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 227882008015 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly...; Region: CpaE_like; cd03111 227882008016 SAF domain; Region: SAF; cl00555 227882008017 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 227882008018 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18 (...; Region: GH18_chitinase_D-like; cd02871 227882008019 Glyco_18 domain; Region: Glyco_18; smart00636 227882008020 putative active site [active] 227882008021 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882008022 Peptidase M14-like domain of carboxypeptidase (CP) T (CPT), CPT belongs to the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding CPs which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a...; Region: M14_CPT; cd03859 227882008023 putative active site [active] 227882008024 Zn-binding site [ion binding]; other site 227882008025 Ycf46; Provisional; Region: ycf46; CHL00195 227882008026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882008027 Walker A motif; other site 227882008028 ATP binding site [chemical binding]; other site 227882008029 Walker B motif; other site 227882008030 arginine finger; other site 227882008031 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 227882008032 CHAT domain; Region: CHAT; cl02083 227882008033 RES domain; Region: RES; cl02411 227882008034 GntP family permease; Region: GntP_permease; cl15264 227882008035 gluconate transporter; Region: gntP; TIGR00791 227882008036 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 227882008037 homotrimer interaction site [polypeptide binding]; other site 227882008038 putative active site [active] 227882008039 Transcriptional regulator [Transcription]; Region: IclR; COG1414 227882008040 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882008041 Bacterial transcriptional regulator; Region: IclR; pfam01614 227882008042 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 227882008043 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 227882008044 substrate binding site [chemical binding]; other site 227882008045 ATP binding site [chemical binding]; other site 227882008046 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 227882008047 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 227882008048 dimer interface [polypeptide binding]; other site 227882008049 active site 227882008050 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 227882008051 substrate binding site [chemical binding]; other site 227882008052 catalytic residue [active] 227882008053 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 227882008054 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 227882008055 active site 227882008056 putative substrate binding pocket [chemical binding]; other site 227882008057 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 227882008058 tyrosine aminotransferase, eukaryotic; Region: tyr_amTase_E; TIGR01264 227882008059 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 227882008060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882008061 homodimer interface [polypeptide binding]; other site 227882008062 catalytic residue [active] 227882008063 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 227882008064 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 227882008065 active site 227882008066 substrate-binding site [chemical binding]; other site 227882008067 metal-binding site [ion binding] 227882008068 GTP binding site [chemical binding]; other site 227882008069 Haemolysin-III related; Region: HlyIII; cl03831 227882008070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882008071 Major Facilitator Superfamily; Region: MFS_1; pfam07690 227882008072 putative substrate translocation pore; other site 227882008073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882008074 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 227882008075 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882008076 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 227882008077 Protein of unknown function DUF82; Region: DUF82; pfam01927 227882008078 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 227882008079 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 227882008080 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 227882008081 Ligand binding site [chemical binding]; other site 227882008082 Putative Catalytic site [active] 227882008083 DXD motif; other site 227882008084 GtrA-like protein; Region: GtrA; cl00971 227882008085 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 227882008086 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 227882008087 active site 227882008088 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 227882008089 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein...; Region: SSP411; cd02955 227882008090 catalytic residues [active] 227882008091 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 227882008092 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 227882008093 domain; Region: GreA_GreB_N; pfam03449 227882008094 C-term; Region: GreA_GreB; pfam01272 227882008095 threonine dehydratase; Provisional; Region: PRK08198 227882008096 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 227882008097 tetramer interface [polypeptide binding]; other site 227882008098 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882008099 catalytic residue [active] 227882008100 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 227882008101 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882008102 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 227882008103 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882008104 DNA binding residues [nucleotide binding] 227882008105 cystathionine gamma-synthase; Provisional; Region: PRK07811 227882008106 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 227882008107 homodimer interface [polypeptide binding]; other site 227882008108 substrate-cofactor binding pocket; other site 227882008109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882008110 catalytic residue [active] 227882008111 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 227882008112 Restriction endonuclease; Region: Mrr_cat; cl00747 227882008113 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 227882008114 putative metal binding site [ion binding]; other site 227882008115 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 227882008116 proposed catalytic triad [active] 227882008117 active site nucleophile [active] 227882008118 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 227882008119 ABC-ATPase subunit interface; other site 227882008120 dimer interface [polypeptide binding]; other site 227882008121 putative PBP binding regions; other site 227882008122 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 227882008123 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 227882008124 putative NAD(P) binding site [chemical binding]; other site 227882008125 putative substrate binding site [chemical binding]; other site 227882008126 catalytic Zn binding site [ion binding]; other site 227882008127 structural Zn binding site [ion binding]; other site 227882008128 dimer interface [polypeptide binding]; other site 227882008129 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 227882008130 salt bridge; other site 227882008131 non-specific DNA binding site [nucleotide binding]; other site 227882008132 sequence-specific DNA binding site [nucleotide binding]; other site 227882008133 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 227882008134 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 227882008135 apolar tunnel; other site 227882008136 heme binding site [chemical binding]; other site 227882008137 dimerization interface [polypeptide binding]; other site 227882008138 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 227882008139 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882008140 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882008141 DNA binding residues [nucleotide binding] 227882008142 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 227882008143 active site 227882008144 catalytic triad [active] 227882008145 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 227882008146 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 227882008147 Walker A/P-loop; other site 227882008148 ATP binding site [chemical binding]; other site 227882008149 Q-loop/lid; other site 227882008150 ABC transporter signature motif; other site 227882008151 Walker B; other site 227882008152 D-loop; other site 227882008153 H-loop/switch region; other site 227882008154 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 227882008155 FtsX-like permease family; Region: FtsX; pfam02687 227882008156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 227882008157 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 227882008158 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 227882008159 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 227882008160 active sites [active] 227882008161 tetramer interface [polypeptide binding]; other site 227882008162 GAF domain; Region: GAF; cl00853 227882008163 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 227882008164 metal binding site [ion binding]; metal-binding site 227882008165 active site 227882008166 I-site; other site 227882008167 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 227882008168 enoyl-CoA hydratase; Provisional; Region: PRK07657 227882008169 substrate binding site [chemical binding]; other site 227882008170 oxyanion hole (OAH) forming residues; other site 227882008171 trimer interface [polypeptide binding]; other site 227882008172 cyclase homology domain; Region: CHD; cd07302 227882008173 nucleotidyl binding site; other site 227882008174 metal binding site [ion binding]; metal-binding site 227882008175 dimer interface [polypeptide binding]; other site 227882008176 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 227882008177 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 227882008178 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 227882008179 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 227882008180 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 227882008181 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 227882008182 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and...; Region: XynE_like; cd01830 227882008183 active site 227882008184 catalytic triad [active] 227882008185 oxyanion hole [active] 227882008186 Maf-like protein; Region: Maf; pfam02545 227882008187 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 227882008188 active site 227882008189 dimer interface [polypeptide binding]; other site 227882008190 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 227882008191 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 227882008192 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 227882008193 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 227882008194 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 227882008195 carboxyltransferase (CT) interaction site; other site 227882008196 biotinylation site [posttranslational modification]; other site 227882008197 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882008198 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 227882008199 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882008200 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 227882008201 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 227882008202 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882008203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882008204 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 227882008205 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 227882008206 putative active site pocket [active] 227882008207 dimerization interface [polypeptide binding]; other site 227882008208 putative catalytic residue [active] 227882008209 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 227882008210 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 227882008211 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1-...; Region: PGM2; cd05799 227882008212 active site 227882008213 substrate binding site [chemical binding]; other site 227882008214 metal binding site [ion binding]; metal-binding site 227882008215 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 227882008216 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 227882008217 intersubunit interface [polypeptide binding]; other site 227882008218 active site 227882008219 catalytic residue [active] 227882008220 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 227882008221 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 227882008222 NAD(P) binding site [chemical binding]; other site 227882008223 catalytic residues [active] 227882008224 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 227882008225 NAD(P) binding site [chemical binding]; other site 227882008226 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882008227 Active site [active] 227882008228 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 227882008229 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882008230 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882008231 DNA binding residues [nucleotide binding] 227882008232 Ycf27; Reviewed; Region: orf27; CHL00148 227882008233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882008234 active site 227882008235 phosphorylation site [posttranslational modification] 227882008236 intermolecular recognition site; other site 227882008237 dimerization interface [polypeptide binding]; other site 227882008238 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882008239 DNA binding site [nucleotide binding] 227882008240 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 227882008241 dimerization interface [polypeptide binding]; other site 227882008242 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 227882008243 dimer interface [polypeptide binding]; other site 227882008244 phosphorylation site [posttranslational modification] 227882008245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882008246 ATP binding site [chemical binding]; other site 227882008247 Mg2+ binding site [ion binding]; other site 227882008248 G-X-G motif; other site 227882008249 VanZ like family; Region: VanZ; cl01971 227882008250 PspC domain; Region: PspC; cl00864 227882008251 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 227882008252 active site 227882008253 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 227882008254 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 227882008255 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882008256 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 227882008257 putative dimerization interface [polypeptide binding]; other site 227882008258 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882008259 putative substrate translocation pore; other site 227882008260 DNA polymerase III subunit beta; Validated; Region: PRK07761 227882008261 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 227882008262 putative DNA binding surface [nucleotide binding]; other site 227882008263 dimer interface [polypeptide binding]; other site 227882008264 beta-clamp/clamp loader binding surface; other site 227882008265 beta-clamp/translesion DNA polymerase binding surface; other site 227882008266 RNA polymerase factor sigma-70; Validated; Region: PRK08241 227882008267 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882008268 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882008269 DNA binding residues [nucleotide binding] 227882008270 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 227882008271 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 227882008272 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 227882008273 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 227882008274 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 227882008275 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 227882008276 active site 227882008277 catalytic motif [active] 227882008278 Zn binding site [ion binding]; other site 227882008279 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 227882008280 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 227882008281 TM-ABC transporter signature motif; other site 227882008282 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 227882008283 TM-ABC transporter signature motif; other site 227882008284 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 227882008285 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 227882008286 Walker A/P-loop; other site 227882008287 ATP binding site [chemical binding]; other site 227882008288 Q-loop/lid; other site 227882008289 ABC transporter signature motif; other site 227882008290 Walker B; other site 227882008291 D-loop; other site 227882008292 H-loop/switch region; other site 227882008293 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 227882008294 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 227882008295 ligand binding site [chemical binding]; other site 227882008296 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 227882008297 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 227882008298 ligand binding site [chemical binding]; other site 227882008299 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 227882008300 amidohydrolase; Region: amidohydrolases; TIGR01891 227882008301 metal binding site [ion binding]; metal-binding site 227882008302 putative dimer interface [polypeptide binding]; other site 227882008303 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 227882008304 NeuB family; Region: NeuB; cl00496 227882008305 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 227882008306 ligand binding site [chemical binding]; other site 227882008307 tetramer interface [polypeptide binding]; other site 227882008308 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882008309 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 227882008310 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 227882008311 active site 227882008312 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 227882008313 tetracycline repressor protein TetR; Provisional; Region: PRK13756 227882008314 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882008315 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 227882008316 hypothetical protein; Provisional; Region: PRK06184 227882008317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882008318 LysE type translocator; Region: LysE; cl00565 227882008319 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 227882008320 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 227882008321 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 227882008322 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 227882008323 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 227882008324 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882008325 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882008326 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 227882008327 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882008328 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882008329 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 227882008330 substrate binding site [chemical binding]; other site 227882008331 FG-GAP repeat; Region: FG-GAP; cl15299 227882008332 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1...; Region: GH20_DspB_LnbB-like; cd06564 227882008333 active site 227882008334 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 227882008335 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 227882008336 putative Iron-sulfur protein interface [polypeptide binding]; other site 227882008337 putative proximal heme binding site [chemical binding]; other site 227882008338 putative SdhD-like interface [polypeptide binding]; other site 227882008339 putative distal heme binding site [chemical binding]; other site 227882008340 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 227882008341 putative Iron-sulfur protein interface [polypeptide binding]; other site 227882008342 putative proximal heme binding site [chemical binding]; other site 227882008343 putative SdhC-like subunit interface [polypeptide binding]; other site 227882008344 putative distal heme binding site [chemical binding]; other site 227882008345 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 227882008346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882008347 domain; Region: Succ_DH_flav_C; pfam02910 227882008348 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 227882008349 TM2 domain; Region: TM2; cl00984 227882008350 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 227882008351 TM2 domain; Region: TM2; cl00984 227882008352 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 227882008353 active site 227882008354 metal binding site [ion binding]; metal-binding site 227882008355 Protein of unknown function, DUF393; Region: DUF393; cl01136 227882008356 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882008357 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882008358 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 227882008359 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 227882008360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882008361 active site 227882008362 phosphorylation site [posttranslational modification] 227882008363 intermolecular recognition site; other site 227882008364 dimerization interface [polypeptide binding]; other site 227882008365 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882008366 DNA binding site [nucleotide binding] 227882008367 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882008368 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 227882008369 dimer interface [polypeptide binding]; other site 227882008370 phosphorylation site [posttranslational modification] 227882008371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882008372 ATP binding site [chemical binding]; other site 227882008373 Mg2+ binding site [ion binding]; other site 227882008374 G-X-G motif; other site 227882008375 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 227882008376 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 227882008377 putative active site [active] 227882008378 putative metal binding site [ion binding]; other site 227882008379 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 227882008380 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 227882008381 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 227882008382 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882008383 NAD(P) binding site [chemical binding]; other site 227882008384 active site 227882008385 2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514 227882008386 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 227882008387 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 227882008388 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 227882008389 active site 227882008390 HIGH motif; other site 227882008391 dimer interface [polypeptide binding]; other site 227882008392 KMSKS motif; other site 227882008393 serine hydroxymethyltransferase; Provisional; Region: PRK13580 227882008394 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 227882008395 dimer interface [polypeptide binding]; other site 227882008396 glycine-pyridoxal phosphate binding site [chemical binding]; other site 227882008397 active site 227882008398 folate binding site [chemical binding]; other site 227882008399 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 227882008400 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 227882008401 inhibitor-cofactor binding pocket; inhibition site 227882008402 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882008403 catalytic residue [active] 227882008404 Glutathionylspermidine synthase; Region: GSP_synth; cl00503 227882008405 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882008406 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 227882008407 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882008408 DNA-binding site [nucleotide binding]; DNA binding site 227882008409 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 227882008410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882008411 homodimer interface [polypeptide binding]; other site 227882008412 catalytic residue [active] 227882008413 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 227882008414 Uncharacterized conserved protein [Function unknown]; Region: COG2128 227882008415 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 227882008416 tetramer interface [polypeptide binding]; other site 227882008417 active site 227882008418 Mg2+/Mn2+ binding site [ion binding]; other site 227882008419 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 227882008420 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 227882008421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882008422 dimer interface [polypeptide binding]; other site 227882008423 conserved gate region; other site 227882008424 putative PBP binding loops; other site 227882008425 ABC-ATPase subunit interface; other site 227882008426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 227882008427 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 227882008428 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 227882008429 Walker A/P-loop; other site 227882008430 ATP binding site [chemical binding]; other site 227882008431 Q-loop/lid; other site 227882008432 ABC transporter signature motif; other site 227882008433 Walker B; other site 227882008434 D-loop; other site 227882008435 H-loop/switch region; other site 227882008436 choline dehydrogenase; Validated; Region: PRK02106 227882008437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882008438 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 227882008439 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 227882008440 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 227882008441 NAD(P) binding site [chemical binding]; other site 227882008442 catalytic residues [active] 227882008443 malate dehydrogenase; Provisional; Region: PRK05442 227882008444 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 227882008445 NAD(P) binding site [chemical binding]; other site 227882008446 dimer interface [polypeptide binding]; other site 227882008447 malate binding site [chemical binding]; other site 227882008448 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882008449 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 227882008450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 227882008451 non-specific DNA binding site [nucleotide binding]; other site 227882008452 salt bridge; other site 227882008453 sequence-specific DNA binding site [nucleotide binding]; other site 227882008454 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 227882008455 non-specific DNA binding site [nucleotide binding]; other site 227882008456 salt bridge; other site 227882008457 sequence-specific DNA binding site [nucleotide binding]; other site 227882008458 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 227882008459 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 227882008460 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 227882008461 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 227882008462 homodimer interface [polypeptide binding]; other site 227882008463 NADP binding site [chemical binding]; other site 227882008464 substrate binding site [chemical binding]; other site 227882008465 RDD family; Region: RDD; cl00746 227882008466 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 227882008467 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 227882008468 purine monophosphate binding site [chemical binding]; other site 227882008469 dimer interface [polypeptide binding]; other site 227882008470 putative catalytic residues [active] 227882008471 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 227882008472 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 227882008473 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 227882008474 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 227882008475 active site 227882008476 substrate binding site [chemical binding]; other site 227882008477 cosubstrate binding site; other site 227882008478 catalytic site [active] 227882008479 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 227882008480 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 227882008481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882008482 CoA-ligase; Region: Ligase_CoA; pfam00549 227882008483 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 227882008484 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 227882008485 CoA-ligase; Region: Ligase_CoA; pfam00549 227882008486 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 227882008487 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: VWA_YIEM_type; cd01462 227882008488 metal ion-dependent adhesion site (MIDAS); other site 227882008489 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 227882008490 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 227882008491 SWIM zinc finger; Region: SWIM; cl11618 227882008492 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen...; Region: MM_CoA_mut_B12_BD; cd02071 227882008493 B12 binding site [chemical binding]; other site 227882008494 cobalt ligand [ion binding]; other site 227882008495 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882008496 Peptidase family M23; Region: Peptidase_M23; pfam01551 227882008497 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 227882008498 UvrD/REP helicase; Region: UvrD-helicase; cl14126 227882008499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 227882008500 NlpC/P60 family; Region: NLPC_P60; cl11438 227882008501 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 227882008502 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 227882008503 gating phenylalanine in ion channel; other site 227882008504 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 227882008505 NlpC/P60 family; Region: NLPC_P60; cl11438 227882008506 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882008507 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882008508 active site 227882008509 phosphorylation site [posttranslational modification] 227882008510 intermolecular recognition site; other site 227882008511 dimerization interface [polypeptide binding]; other site 227882008512 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882008513 DNA binding residues [nucleotide binding] 227882008514 dimerization interface [polypeptide binding]; other site 227882008515 PspC domain; Region: PspC; cl00864 227882008516 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 227882008517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882008518 PspC domain; Region: PspC; cl00864 227882008519 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 227882008520 active site 227882008521 intersubunit interface [polypeptide binding]; other site 227882008522 Zn2+ binding site [ion binding]; other site 227882008523 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 227882008524 GMP synthase; Reviewed; Region: guaA; PRK00074 227882008525 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 227882008526 AMP/PPi binding site [chemical binding]; other site 227882008527 candidate oxyanion hole; other site 227882008528 catalytic triad [active] 227882008529 potential glutamine specificity residues [chemical binding]; other site 227882008530 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 227882008531 ATP Binding subdomain [chemical binding]; other site 227882008532 Ligand Binding sites [chemical binding]; other site 227882008533 Dimerization subdomain; other site 227882008534 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 227882008535 dimer interface [polypeptide binding]; other site 227882008536 phosphorylation site [posttranslational modification] 227882008537 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882008538 ATP binding site [chemical binding]; other site 227882008539 Mg2+ binding site [ion binding]; other site 227882008540 G-X-G motif; other site 227882008541 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 227882008542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882008543 active site 227882008544 phosphorylation site [posttranslational modification] 227882008545 intermolecular recognition site; other site 227882008546 dimerization interface [polypeptide binding]; other site 227882008547 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882008548 DNA binding site [nucleotide binding] 227882008549 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 227882008550 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 227882008551 phosphoglycerate mutase; Provisional; Region: PTZ00122 227882008552 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 227882008553 catalytic core [active] 227882008554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882008555 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 227882008556 anti sigma factor interaction site; other site 227882008557 regulatory phosphorylation site [posttranslational modification]; other site 227882008558 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 227882008559 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882008560 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 227882008561 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882008562 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cl00126 227882008563 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 227882008564 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria...; Region: Imidazolone-5PH; cd01296 227882008565 active site 227882008566 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 227882008567 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 227882008568 active site 227882008569 allantoate amidohydrolase; Reviewed; Region: PRK09290 227882008570 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 227882008571 active site 227882008572 metal binding site [ion binding]; metal-binding site 227882008573 dimer interface [polypeptide binding]; other site 227882008574 urocanate hydratase; Provisional; Region: PRK05414 227882008575 urocanate hydratase; Region: hutU; TIGR01228 227882008576 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Uncharacterized Proteins with similarity to Ornithine and Diaminopimelate Decarboxylases; Region: PLPDE_III_ODC_DapDC_like_1; cd06836 227882008577 active site 227882008578 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 227882008579 dimer interface [polypeptide binding]; other site 227882008580 catalytic residues [active] 227882008581 substrate binding site [chemical binding]; other site 227882008582 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 227882008583 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 227882008584 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 227882008585 putative active site [active] 227882008586 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 227882008587 active sites [active] 227882008588 tetramer interface [polypeptide binding]; other site 227882008589 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 227882008590 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 227882008591 Walker A/P-loop; other site 227882008592 ATP binding site [chemical binding]; other site 227882008593 Q-loop/lid; other site 227882008594 ABC transporter signature motif; other site 227882008595 Walker B; other site 227882008596 D-loop; other site 227882008597 H-loop/switch region; other site 227882008598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882008599 dimer interface [polypeptide binding]; other site 227882008600 conserved gate region; other site 227882008601 putative PBP binding loops; other site 227882008602 ABC-ATPase subunit interface; other site 227882008603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 227882008604 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 227882008605 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 227882008606 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 227882008607 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 227882008608 dimer interface [polypeptide binding]; other site 227882008609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882008610 catalytic residue [active] 227882008611 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as...; Region: CBS_pair_PALP_assoc2; cd04609 227882008612 FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it turn are loaded onto the acyl...; Region: FeeA_FeeB_like; cd01836 227882008613 active site 227882008614 catalytic triad [active] 227882008615 oxyanion hole [active] 227882008616 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 227882008617 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 227882008618 dimer interface [polypeptide binding]; other site 227882008619 active site 227882008620 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 227882008621 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 227882008622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882008623 Cytochrome P450; Region: p450; cl12078 227882008624 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 227882008625 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by...; Region: init_cond_enzymes; cd00827 227882008626 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 227882008627 dimer interface [polypeptide binding]; other site 227882008628 active site 227882008629 phosphoenolpyruvate synthase; Validated; Region: PRK06241 227882008630 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 227882008631 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 227882008632 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 227882008633 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 227882008634 A-factor biosynthesis hotdog domain; Region: AfsA; pfam03756 227882008635 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 227882008636 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 227882008637 NADP binding site [chemical binding]; other site 227882008638 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 227882008639 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 227882008640 Walker A/P-loop; other site 227882008641 ATP binding site [chemical binding]; other site 227882008642 Q-loop/lid; other site 227882008643 ABC transporter signature motif; other site 227882008644 Walker B; other site 227882008645 D-loop; other site 227882008646 H-loop/switch region; other site 227882008647 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 227882008648 FtsX-like permease family; Region: FtsX; pfam02687 227882008649 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 227882008650 FtsX-like permease family; Region: FtsX; pfam02687 227882008651 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 227882008652 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882008653 S-adenosylmethionine binding site [chemical binding]; other site 227882008654 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 227882008655 exopolyphosphatase; Region: exo_poly_only; TIGR03706 227882008656 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 227882008657 Protein of unknown function (DUF501); Region: DUF501; cl00652 227882008658 Septum formation initiator; Region: DivIC; cl11433 227882008659 enolase; Provisional; Region: eno; PRK00077 227882008660 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 227882008661 dimer interface [polypeptide binding]; other site 227882008662 metal binding site [ion binding]; metal-binding site 227882008663 substrate binding pocket [chemical binding]; other site 227882008664 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 227882008665 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 227882008666 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 227882008667 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 227882008668 Cytochrome P450; Region: p450; cl12078 227882008669 Protein of unknown function (DUF1089); Region: DUF1089; cl01425 227882008670 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 227882008671 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 227882008672 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins...; Region: GH25_BacA-like; cd06418 227882008673 active site 227882008674 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882008675 Catalytic domain of Protein Kinases; Region: PKc; cd00180 227882008676 active site 227882008677 ATP binding site [chemical binding]; other site 227882008678 substrate binding site [chemical binding]; other site 227882008679 activation loop (A-loop); other site 227882008680 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 227882008681 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 227882008682 Domain of unknown function (DUF1994); Region: DUF1994; pfam09352 227882008683 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882008684 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882008685 classical (c) SDRs; Region: SDR_c; cd05233 227882008686 NAD(P) binding site [chemical binding]; other site 227882008687 active site 227882008688 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 227882008689 DNA binding residues [nucleotide binding] 227882008690 putative dimer interface [polypeptide binding]; other site 227882008691 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 227882008692 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 227882008693 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 227882008694 ATP binding site [chemical binding]; other site 227882008695 putative Mg++ binding site [ion binding]; other site 227882008696 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 227882008697 nucleotide binding region [chemical binding]; other site 227882008698 ATP-binding site [chemical binding]; other site 227882008699 TRCF domain; Region: TRCF; cl04088 227882008700 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 227882008701 FtsX-like permease family; Region: FtsX; pfam02687 227882008702 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 227882008703 FtsX-like permease family; Region: FtsX; pfam02687 227882008704 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 227882008705 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 227882008706 Walker A/P-loop; other site 227882008707 ATP binding site [chemical binding]; other site 227882008708 Q-loop/lid; other site 227882008709 ABC transporter signature motif; other site 227882008710 Walker B; other site 227882008711 D-loop; other site 227882008712 H-loop/switch region; other site 227882008713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882008714 putative substrate translocation pore; other site 227882008715 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 227882008716 Sodium:solute symporter family; Region: SSF; cl00456 227882008717 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 227882008718 Histidine kinase; Region: HisKA_3; pfam07730 227882008719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882008720 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 227882008721 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 227882008722 Substrate binding site [chemical binding]; other site 227882008723 Mg++ binding site [ion binding]; other site 227882008724 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 227882008725 active site 227882008726 substrate binding site [chemical binding]; other site 227882008727 CoA binding site [chemical binding]; other site 227882008728 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 227882008729 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 227882008730 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 227882008731 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 227882008732 5S rRNA interface [nucleotide binding]; other site 227882008733 CTC domain interface [polypeptide binding]; other site 227882008734 L16 interface [polypeptide binding]; other site 227882008735 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 227882008736 putative active site [active] 227882008737 catalytic residue [active] 227882008738 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 227882008739 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 227882008740 Fatty acid desaturase; Region: FA_desaturase; pfam00487 227882008741 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 227882008742 Di-iron ligands [ion binding]; other site 227882008743 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882008744 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882008745 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 227882008746 dimer interface [polypeptide binding]; other site 227882008747 putative metal binding site [ion binding]; other site 227882008748 trans-aconitate 2-methyltransferase; Provisional; Region: PRK01683 227882008749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882008750 S-adenosylmethionine binding site [chemical binding]; other site 227882008751 MBOAT family; Region: MBOAT; cl00738 227882008752 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882008753 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882008754 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882008755 intermolecular recognition site; other site 227882008756 active site 227882008757 dimerization interface [polypeptide binding]; other site 227882008758 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882008759 DNA binding residues [nucleotide binding] 227882008760 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 227882008761 Coenzyme A binding pocket [chemical binding]; other site 227882008762 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 227882008763 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 227882008764 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 227882008765 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 227882008766 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 227882008767 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 227882008768 NAD binding site [chemical binding]; other site 227882008769 homodimer interface [polypeptide binding]; other site 227882008770 active site 227882008771 substrate binding site [chemical binding]; other site 227882008772 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 227882008773 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 227882008774 dimer interface [polypeptide binding]; other site 227882008775 active site 227882008776 Sodium:solute symporter family; Region: SSF; cl00456 227882008777 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 227882008778 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882008779 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882008780 DNA binding residues [nucleotide binding] 227882008781 dimerization interface [polypeptide binding]; other site 227882008782 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 227882008783 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 227882008784 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 227882008785 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 227882008786 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882008787 Walker A/P-loop; other site 227882008788 ATP binding site [chemical binding]; other site 227882008789 Q-loop/lid; other site 227882008790 ABC transporter signature motif; other site 227882008791 Walker B; other site 227882008792 D-loop; other site 227882008793 H-loop/switch region; other site 227882008794 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 227882008795 Acyltransferase family; Region: Acyl_transf_3; pfam01757 227882008796 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 227882008797 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882008798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 227882008799 Domain of unknown function (DUF348); Region: DUF348; pfam03990 227882008800 Domain of unknown function (DUF348); Region: DUF348; pfam03990 227882008801 Domain of unknown function (DUF348); Region: DUF348; pfam03990 227882008802 G5 domain; Region: G5; pfam07501 227882008803 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 227882008804 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 227882008805 active site 227882008806 Predicted methyltransferases [General function prediction only]; Region: COG0313 227882008807 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 227882008808 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 227882008809 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 227882008810 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 227882008811 nucleoside/Zn binding site; other site 227882008812 dimer interface [polypeptide binding]; other site 227882008813 catalytic motif [active] 227882008814 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 227882008815 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 227882008816 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 227882008817 putative heme binding pocket [chemical binding]; other site 227882008818 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 227882008819 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882008820 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 227882008821 catalytic residue [active] 227882008822 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 227882008823 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 227882008824 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 227882008825 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 227882008826 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 227882008827 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 227882008828 Cobalt transport protein; Region: CbiQ; cl00463 227882008829 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 227882008830 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 227882008831 Walker A/P-loop; other site 227882008832 ATP binding site [chemical binding]; other site 227882008833 Q-loop/lid; other site 227882008834 ABC transporter signature motif; other site 227882008835 Walker B; other site 227882008836 D-loop; other site 227882008837 H-loop/switch region; other site 227882008838 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882008839 OsmC-like protein; Region: OsmC; cl00767 227882008840 Beta-lactamase; Region: Beta-lactamase; cl01009 227882008841 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 227882008842 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 227882008843 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 227882008844 putative deacylase active site [active] 227882008845 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882008846 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 227882008847 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882008848 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882008849 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 227882008850 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 227882008851 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 227882008852 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 227882008853 protein binding site [polypeptide binding]; other site 227882008854 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 227882008855 Domain interface; other site 227882008856 Peptide binding site; other site 227882008857 Active site tetrad [active] 227882008858 short chain dehydrogenase; Provisional; Region: PRK05872 227882008859 classical (c) SDRs; Region: SDR_c; cd05233 227882008860 NAD(P) binding site [chemical binding]; other site 227882008861 active site 227882008862 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882008863 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882008864 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 227882008865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882008866 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 227882008867 DNA binding residues [nucleotide binding] 227882008868 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 227882008869 putative active site [active] 227882008870 putative DNA binding site [nucleotide binding]; other site 227882008871 putative phosphate binding site [ion binding]; other site 227882008872 putative catalytic site [active] 227882008873 metal binding site A [ion binding]; metal-binding site 227882008874 putative AP binding site [nucleotide binding]; other site 227882008875 putative metal binding site B [ion binding]; other site 227882008876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882008877 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 227882008878 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882008879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882008880 active site 227882008881 phosphorylation site [posttranslational modification] 227882008882 intermolecular recognition site; other site 227882008883 dimerization interface [polypeptide binding]; other site 227882008884 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882008885 dimerization interface [polypeptide binding]; other site 227882008886 DNA binding residues [nucleotide binding] 227882008887 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 227882008888 Histidine kinase; Region: HisKA_3; pfam07730 227882008889 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882008890 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 227882008891 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882008892 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 227882008893 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 227882008894 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 227882008895 Walker A/P-loop; other site 227882008896 ATP binding site [chemical binding]; other site 227882008897 Q-loop/lid; other site 227882008898 ABC transporter signature motif; other site 227882008899 Walker B; other site 227882008900 D-loop; other site 227882008901 H-loop/switch region; other site 227882008902 FtsX-like permease family; Region: FtsX; pfam02687 227882008903 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 227882008904 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 227882008905 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 227882008906 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 227882008907 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 227882008908 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 227882008909 H+ Antiporter protein; Region: 2A0121; TIGR00900 227882008910 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 227882008911 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882008912 Condensation domain; Region: Condensation; cl09290 227882008913 L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443 227882008914 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 227882008915 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882008916 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882008917 Condensation domain; Region: Condensation; cl09290 227882008918 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 227882008919 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 227882008920 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882008921 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882008922 Condensation domain; Region: Condensation; cl09290 227882008923 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 227882008924 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882008925 Beta-lactamase; Region: Beta-lactamase; cl01009 227882008926 peptide synthase; Provisional; Region: PRK12467 227882008927 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882008928 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882008929 Condensation domain; Region: Condensation; cl09290 227882008930 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882008931 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882008932 MbtH-like protein; Region: MbtH; cl01279 227882008933 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 227882008934 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882008935 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882008936 Condensation domain; Region: Condensation; cl09290 227882008937 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 227882008938 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 227882008939 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 227882008940 dimer interface [polypeptide binding]; other site 227882008941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882008942 catalytic residue [active] 227882008943 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882008944 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 227882008945 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 227882008946 active site 227882008947 peptide synthase; Validated; Region: PRK05691 227882008948 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882008949 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 227882008950 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 227882008951 active site 227882008952 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 227882008953 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1,2-; Region: DsbA_HCCA_Iso; cd03022 227882008954 putative catalytic residue [active] 227882008955 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 227882008956 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 227882008957 NAD(P) binding site [chemical binding]; other site 227882008958 homotetramer interface [polypeptide binding]; other site 227882008959 homodimer interface [polypeptide binding]; other site 227882008960 active site 227882008961 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 227882008962 active site 2 [active] 227882008963 active site 1 [active] 227882008964 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid...; Region: FabA_FabZ; cd00493 227882008965 active site 2 [active] 227882008966 dimer interface [polypeptide binding]; other site 227882008967 active site 1 [active] 227882008968 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882008969 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 227882008970 active site 227882008971 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 227882008972 classical (c) SDRs; Region: SDR_c; cd05233 227882008973 NAD(P) binding site [chemical binding]; other site 227882008974 active site 227882008975 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 227882008976 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 227882008977 active site 227882008978 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 227882008979 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 227882008980 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 227882008981 active site 227882008982 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 227882008983 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 227882008984 active site 227882008985 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 227882008986 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 227882008987 dimer interface [polypeptide binding]; other site 227882008988 active site 227882008989 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882008990 Predicted transcriptional regulators [Transcription]; Region: COG1378 227882008991 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882008992 DNA binding residues [nucleotide binding] 227882008993 dimerization interface [polypeptide binding]; other site 227882008994 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882008995 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 227882008996 MPT binding site; other site 227882008997 trimer interface [polypeptide binding]; other site 227882008998 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 227882008999 trimer interface [polypeptide binding]; other site 227882009000 dimer interface [polypeptide binding]; other site 227882009001 putative active site [active] 227882009002 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 227882009003 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 227882009004 dimer interface [polypeptide binding]; other site 227882009005 putative functional site; other site 227882009006 putative MPT binding site; other site 227882009007 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 227882009008 active site 227882009009 tetramer interface [polypeptide binding]; other site 227882009010 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 227882009011 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 227882009012 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 227882009013 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-...; Region: Ntn_PGA_like; cd03747 227882009014 active site 227882009015 potassium/proton antiporter; Reviewed; Region: PRK05326 227882009016 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 227882009017 Major Facilitator Superfamily; Region: MFS_1; pfam07690 227882009018 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 227882009019 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 227882009020 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 227882009021 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 227882009022 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 227882009023 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of highly-; Region: nylC_like; cd02252 227882009024 putative active site pocket [active] 227882009025 cleavage site 227882009026 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 227882009027 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 227882009028 active site 227882009029 phosphorylation site [posttranslational modification] 227882009030 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 227882009031 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 227882009032 P-loop; other site 227882009033 active site 227882009034 phosphorylation site [posttranslational modification] 227882009035 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 227882009036 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 227882009037 putative substrate binding site [chemical binding]; other site 227882009038 putative ATP binding site [chemical binding]; other site 227882009039 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 227882009040 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882009041 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 227882009042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882009043 Major Facilitator Superfamily; Region: MFS_1; pfam07690 227882009044 putative substrate translocation pore; other site 227882009045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882009046 Predicted transcriptional regulator [Transcription]; Region: COG2378 227882009047 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 227882009048 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882009049 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 227882009050 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 227882009051 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882009052 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 227882009053 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882009054 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 227882009055 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882009056 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 227882009057 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 227882009058 putative active site [active] 227882009059 metal binding site [ion binding]; metal-binding site 227882009060 Transcriptional regulators [Transcription]; Region: MarR; COG1846 227882009061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882009062 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 227882009063 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882009064 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882009065 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882009066 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 227882009067 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 227882009068 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882009069 Bacterial transcriptional regulator; Region: IclR; pfam01614 227882009070 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 227882009071 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882009072 Bacterial transcriptional regulator; Region: IclR; pfam01614 227882009073 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882009074 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882009075 Cytochrome P450; Region: p450; cl12078 227882009076 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882009077 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882009078 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882009079 active site 227882009080 Acyl-CoA oxidase; Region: ACOX; pfam01756 227882009081 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 227882009082 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 227882009083 catalytic Zn binding site [ion binding]; other site 227882009084 NAD(P) binding site [chemical binding]; other site 227882009085 structural Zn binding site [ion binding]; other site 227882009086 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 227882009087 Phage integrase family; Region: Phage_integrase; pfam00589 227882009088 Int/Topo IB signature motif; other site 227882009089 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 227882009090 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 227882009091 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 227882009092 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882009093 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 227882009094 Active Sites [active] 227882009095 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 227882009096 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882009097 DNA-binding site [nucleotide binding]; DNA binding site 227882009098 UTRA domain; Region: UTRA; cl01230 227882009099 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 227882009100 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 227882009101 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 227882009102 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882009103 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 227882009104 DNA binding site [nucleotide binding] 227882009105 Int/Topo IB signature motif; other site 227882009106 active site 227882009107 Mobile element transfer protein; Region: SpdB; pfam05122 227882009108 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 227882009109 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882009110 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 227882009111 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882009112 DNA-binding site [nucleotide binding]; DNA binding site 227882009113 UTRA domain; Region: UTRA; cl01230 227882009114 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 227882009115 nudix motif; other site 227882009116 IS2 transposase TnpB; Reviewed; Region: PRK09409 227882009117 Integrase core domain; Region: rve; cl01316 227882009118 DGQHR domain; Region: DGQHR; cl14002 227882009119 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cl00083 227882009120 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 227882009121 FG-GAP repeat; Region: FG-GAP; cl15299 227882009122 FG-GAP repeat; Region: FG-GAP; cl15299 227882009123 FG-GAP repeat; Region: FG-GAP; cl15299 227882009124 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 227882009125 FAD binding domain; Region: FAD_binding_4; pfam01565 227882009126 Berberine and berberine like; Region: BBE; pfam08031 227882009127 Low molecular weight phosphatase family; Region: LMWPc; cd00115 227882009128 Active site [active] 227882009129 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 227882009130 dimerization interface [polypeptide binding]; other site 227882009131 putative DNA binding site [nucleotide binding]; other site 227882009132 putative Zn2+ binding site [ion binding]; other site 227882009133 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 227882009134 putative metal binding site [ion binding]; other site 227882009135 Ion channel; Region: Ion_trans_2; cl11596 227882009136 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882009137 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882009138 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882009139 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 227882009140 LysE type translocator; Region: LysE; cl00565 227882009141 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 227882009142 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882009143 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882009144 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 227882009145 catalytic residue [active] 227882009146 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882009147 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 227882009148 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 227882009149 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 227882009150 Zn binding site [ion binding]; other site 227882009151 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 227882009152 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 227882009153 ligand binding site [chemical binding]; other site 227882009154 flexible hinge region; other site 227882009155 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 227882009156 putative DNA binding site [nucleotide binding]; other site 227882009157 dimerization interface [polypeptide binding]; other site 227882009158 putative Zn2+ binding site [ion binding]; other site 227882009159 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue...; Region: GSH_Peroxidase; cd00340 227882009160 catalytic residues [active] 227882009161 dimer interface [polypeptide binding]; other site 227882009162 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 227882009163 DNA binding residues [nucleotide binding] 227882009164 drug binding residues [chemical binding]; other site 227882009165 dimer interface [polypeptide binding]; other site 227882009166 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; cl01368 227882009167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882009168 putative substrate translocation pore; other site 227882009169 dihydrolipoamide succinyltransferase; Provisional; Region: PTZ00144 227882009170 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 227882009171 Beta-lactamase; Region: Beta-lactamase; cl01009 227882009172 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 227882009173 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 227882009174 sequence-specific DNA binding site [nucleotide binding]; other site 227882009175 salt bridge; other site 227882009176 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882009177 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 227882009178 classical (c) SDRs; Region: SDR_c; cd05233 227882009179 NAD(P) binding site [chemical binding]; other site 227882009180 active site 227882009181 Sodium:solute symporter family; Region: SSF; cl00456 227882009182 putative transporter; Provisional; Region: PRK10484 227882009183 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 227882009184 FG-GAP repeat; Region: FG-GAP; cl15299 227882009185 FG-GAP repeat; Region: FG-GAP; cl15299 227882009186 FG-GAP repeat; Region: FG-GAP; cl15299 227882009187 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 227882009188 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 227882009189 calcium mediated ligand binding site; other site 227882009190 intermolecular salt bridges; other site 227882009191 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 227882009192 FO synthase; Reviewed; Region: fbiC; PRK09234 227882009193 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 227882009194 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 227882009195 FeS/SAM binding site; other site 227882009196 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 227882009197 Domain of unknown function (DUF385); Region: DUF385; cl04387 227882009198 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 227882009199 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 227882009200 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 227882009201 NAD binding site [chemical binding]; other site 227882009202 catalytic residues [active] 227882009203 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 227882009204 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 227882009205 active site 227882009206 putative substrate binding pocket [chemical binding]; other site 227882009207 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 227882009208 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 227882009209 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882009210 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882009211 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 227882009212 NAD(P) binding site [chemical binding]; other site 227882009213 active site 227882009214 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882009215 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 227882009216 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 227882009217 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882009218 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 227882009219 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 227882009220 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882009221 lipid-transfer protein; Provisional; Region: PRK07855 227882009222 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 227882009223 active site 227882009224 DUF35 OB-fold domain; Region: DUF35; pfam01796 227882009225 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 227882009226 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 227882009227 substrate binding site [chemical binding]; other site 227882009228 oxyanion hole (OAH) forming residues; other site 227882009229 trimer interface [polypeptide binding]; other site 227882009230 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882009231 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882009232 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 227882009233 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882009234 Prostaglandin dehydrogenases; Region: PGDH; cd05288 227882009235 NAD(P) binding site [chemical binding]; other site 227882009236 dimer interface [polypeptide binding]; other site 227882009237 substrate binding site [chemical binding]; other site 227882009238 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882009239 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882009240 active site 227882009241 ATP binding site [chemical binding]; other site 227882009242 substrate binding site [chemical binding]; other site 227882009243 activation loop (A-loop); other site 227882009244 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 227882009245 Trp docking motif; other site 227882009246 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 227882009247 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 227882009248 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882009249 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882009250 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882009251 Active site [active] 227882009252 Domain of unknown function (DUF385); Region: DUF385; cl04387 227882009253 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 227882009254 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 227882009255 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882009256 active site 227882009257 thiolase; Provisional; Region: PRK06158 227882009258 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 227882009259 active site 227882009260 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 227882009261 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 227882009262 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 227882009263 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 227882009264 DUF35 OB-fold domain; Region: DUF35; pfam01796 227882009265 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 227882009266 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 227882009267 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 227882009268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882009269 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 227882009270 enoyl-CoA hydratase; Provisional; Region: PRK08140 227882009271 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 227882009272 substrate binding site [chemical binding]; other site 227882009273 oxyanion hole (OAH) forming residues; other site 227882009274 trimer interface [polypeptide binding]; other site 227882009275 Flavin Reductases; Region: FlaRed; cl00801 227882009276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882009277 Major Facilitator Superfamily; Region: MFS_1; pfam07690 227882009278 putative substrate translocation pore; other site 227882009279 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 227882009280 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 227882009281 conserved cys residue [active] 227882009282 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882009283 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882009284 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 227882009285 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 227882009286 NAD binding site [chemical binding]; other site 227882009287 catalytic Zn binding site [ion binding]; other site 227882009288 substrate binding site [chemical binding]; other site 227882009289 structural Zn binding site [ion binding]; other site 227882009290 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 227882009291 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882009292 active site 227882009293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882009294 NAD(P) binding site [chemical binding]; other site 227882009295 active site 227882009296 Putative cyclase; Region: Cyclase; cl00814 227882009297 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882009298 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 227882009299 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882009300 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 227882009301 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 227882009302 FAD binding site [chemical binding]; other site 227882009303 substrate binding site [chemical binding]; other site 227882009304 catalytic base [active] 227882009305 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 227882009306 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 227882009307 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882009308 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading...; Region: EFh; cd00051 227882009309 Ca2+ binding site [ion binding]; other site 227882009310 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 227882009311 anti sigma factor interaction site; other site 227882009312 regulatory phosphorylation site [posttranslational modification]; other site 227882009313 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 227882009314 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882009315 DinB superfamily; Region: DinB_2; cl00986 227882009316 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 227882009317 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 227882009318 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 227882009319 putative active site [active] 227882009320 putative substrate binding site [chemical binding]; other site 227882009321 putative cosubstrate binding site; other site 227882009322 catalytic site [active] 227882009323 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 227882009324 putative ligand binding site [chemical binding]; other site 227882009325 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 227882009326 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 227882009327 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 227882009328 Walker A/P-loop; other site 227882009329 ATP binding site [chemical binding]; other site 227882009330 Q-loop/lid; other site 227882009331 ABC transporter signature motif; other site 227882009332 Walker B; other site 227882009333 D-loop; other site 227882009334 H-loop/switch region; other site 227882009335 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882009336 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882009337 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882009338 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 227882009339 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 227882009340 FeoA domain; Region: FeoA; cl00838 227882009341 hypothetical protein; Provisional; Region: PRK02947 227882009342 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 227882009343 putative active site [active] 227882009344 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 227882009345 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 227882009346 putative active site [active] 227882009347 heme pocket [chemical binding]; other site 227882009348 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 227882009349 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 227882009350 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 227882009351 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 227882009352 dimer interface [polypeptide binding]; other site 227882009353 Citrate synthase; Region: Citrate_synt; pfam00285 227882009354 active site 227882009355 citrylCoA binding site [chemical binding]; other site 227882009356 oxalacetate/citrate binding site [chemical binding]; other site 227882009357 coenzyme A binding site [chemical binding]; other site 227882009358 catalytic triad [active] 227882009359 flavanone-3-hydroxylase; Provisional; Region: PLN03176 227882009360 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 227882009361 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 227882009362 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882009363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882009364 enoyl-CoA hydratase; Provisional; Region: PRK07827 227882009365 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 227882009366 substrate binding site [chemical binding]; other site 227882009367 oxyanion hole (OAH) forming residues; other site 227882009368 trimer interface [polypeptide binding]; other site 227882009369 4-coumarate--CoA ligase; Region: PLN02246 227882009370 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882009371 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 227882009372 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 227882009373 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 227882009374 active site 227882009375 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 227882009376 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 227882009377 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 227882009378 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 227882009379 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 227882009380 carboxyltransferase (CT) interaction site; other site 227882009381 biotinylation site [posttranslational modification]; other site 227882009382 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 227882009383 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 227882009384 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 227882009385 TIGR03084 family protein; Region: TIGR03084 227882009386 DinB superfamily; Region: DinB_2; cl00986 227882009387 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 227882009388 malate dehydrogenase; Provisional; Region: PRK13529 227882009389 Malic enzyme, N-terminal domain; Region: malic; pfam00390 227882009390 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 227882009391 NAD(P) binding site [chemical binding]; other site 227882009392 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 227882009393 EamA-like transporter family; Region: EamA; cl01037 227882009394 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 227882009395 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 227882009396 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882009397 Walker A/P-loop; other site 227882009398 ATP binding site [chemical binding]; other site 227882009399 Q-loop/lid; other site 227882009400 ABC transporter signature motif; other site 227882009401 Walker B; other site 227882009402 D-loop; other site 227882009403 H-loop/switch region; other site 227882009404 FemAB family; Region: FemAB; cl11444 227882009405 FemAB family; Region: FemAB; cl11444 227882009406 FAD binding domain; Region: FAD_binding_4; pfam01565 227882009407 FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913 227882009408 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 227882009409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882009410 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 227882009411 Protein of unknown function (DUF742); Region: DUF742; pfam05331 227882009412 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 227882009413 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 227882009414 G1 box; other site 227882009415 GTP/Mg2+ binding site [chemical binding]; other site 227882009416 G2 box; other site 227882009417 Switch I region; other site 227882009418 G3 box; other site 227882009419 Switch II region; other site 227882009420 G4 box; other site 227882009421 G5 box; other site 227882009422 Cytochrome P450; Region: p450; cl12078 227882009423 Cytochrome P450; Region: p450; cl12078 227882009424 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882009425 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 227882009426 catalytic residue [active] 227882009427 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 227882009428 active site 227882009429 oxyanion hole [active] 227882009430 catalytic triad [active] 227882009431 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882009432 S-adenosylmethionine binding site [chemical binding]; other site 227882009433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882009434 Major Facilitator Superfamily; Region: MFS_1; pfam07690 227882009435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882009436 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 227882009437 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882009438 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 227882009439 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 227882009440 active site 227882009441 catalytic tetrad [active] 227882009442 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 227882009443 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 227882009444 NAD(P) binding site [chemical binding]; other site 227882009445 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 227882009446 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 227882009447 H+ Antiporter protein; Region: 2A0121; TIGR00900 227882009448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882009449 putative substrate translocation pore; other site 227882009450 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882009451 Sulfate transporter family; Region: Sulfate_transp; cl00967 227882009452 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 227882009453 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 227882009454 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882009455 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882009456 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 227882009457 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 227882009458 H+ Antiporter protein; Region: 2A0121; TIGR00900 227882009459 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 227882009460 Putative periplasminc binding protein (DUF178); Region: DUF178; cl15271 227882009461 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 227882009462 DNA-binding site [nucleotide binding]; DNA binding site 227882009463 RNA-binding motif; other site 227882009464 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882009465 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 227882009466 Predicted transcriptional regulator [Transcription]; Region: COG2378 227882009467 DNA repair helicase rad25; Region: rad25; TIGR00603 227882009468 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 227882009469 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 227882009470 ATP binding site [chemical binding]; other site 227882009471 putative Mg++ binding site [ion binding]; other site 227882009472 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 227882009473 nucleotide binding region [chemical binding]; other site 227882009474 ATP-binding site [chemical binding]; other site 227882009475 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 227882009476 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 227882009477 UvrD/REP helicase; Region: UvrD-helicase; cl14126 227882009478 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 227882009479 CutC family; Region: CutC; cl01218 227882009480 DinB superfamily; Region: DinB_2; cl00986 227882009481 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 227882009482 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 227882009483 substrate binding pocket [chemical binding]; other site 227882009484 substrate-Mg2+ binding site; other site 227882009485 aspartate-rich region 1; other site 227882009486 aspartate-rich region 2; other site 227882009487 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 227882009488 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 227882009489 putative active site [active] 227882009490 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 227882009491 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 227882009492 putative active site [active] 227882009493 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 227882009494 active site turn [active] 227882009495 phosphorylation site [posttranslational modification] 227882009496 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 227882009497 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 227882009498 anti sigma factor interaction site; other site 227882009499 regulatory phosphorylation site [posttranslational modification]; other site 227882009500 PAS fold; Region: PAS; pfam00989 227882009501 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 227882009502 putative active site [active] 227882009503 heme pocket [chemical binding]; other site 227882009504 GAF domain; Region: GAF; cl00853 227882009505 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882009506 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882009507 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 227882009508 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 227882009509 putative active site [active] 227882009510 putative FMN binding site [chemical binding]; other site 227882009511 putative substrate binding site [chemical binding]; other site 227882009512 putative catalytic residue [active] 227882009513 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 227882009514 putative active site [active] 227882009515 catalytic site [active] 227882009516 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 227882009517 putative active site [active] 227882009518 catalytic site [active] 227882009519 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 227882009520 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 227882009521 ring oligomerisation interface [polypeptide binding]; other site 227882009522 ATP/Mg binding site [chemical binding]; other site 227882009523 stacking interactions; other site 227882009524 hinge regions; other site 227882009525 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 227882009526 DNA-binding site [nucleotide binding]; DNA binding site 227882009527 RNA-binding motif; other site 227882009528 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 227882009529 MoaE interaction surface [polypeptide binding]; other site 227882009530 MoeB interaction surface [polypeptide binding]; other site 227882009531 thiocarboxylated glycine; other site 227882009532 threonine synthase; Validated; Region: PRK07591 227882009533 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 227882009534 homodimer interface [polypeptide binding]; other site 227882009535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882009536 catalytic residue [active] 227882009537 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 227882009538 active site 227882009539 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is...; Region: GT1_TPS; cd03788 227882009540 Glycosyltransferase family 20; Region: Glyco_transf_20; pfam00982 227882009541 active site 227882009542 homotetramer interface [polypeptide binding]; other site 227882009543 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882009544 Trehalose-phosphatase; Region: Trehalose_PPase; pfam02358 227882009545 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 227882009546 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 227882009547 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882009548 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 227882009549 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882009550 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882009551 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 227882009552 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 227882009553 active site 227882009554 dimer interface [polypeptide binding]; other site 227882009555 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 227882009556 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 227882009557 putative substrate binding site [chemical binding]; other site 227882009558 putative ATP binding site [chemical binding]; other site 227882009559 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 227882009560 putative metal binding site [ion binding]; other site 227882009561 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 227882009562 GAF domain; Region: GAF; cl00853 227882009563 putative diguanylate cyclase; Provisional; Region: PRK09776 227882009564 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 227882009565 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 227882009566 metal binding site [ion binding]; metal-binding site 227882009567 active site 227882009568 I-site; other site 227882009569 Flavin Reductases; Region: FlaRed; cl00801 227882009570 RF-1 domain; Region: RF-1; cl02875 227882009571 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 227882009572 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 227882009573 putative metal binding site [ion binding]; other site 227882009574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882009575 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882009576 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 227882009577 nudix motif; other site 227882009578 Integrase core domain; Region: rve; cl01316 227882009579 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 227882009580 Zn binding site [ion binding]; other site 227882009581 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 227882009582 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 227882009583 putative NAD(P) binding site [chemical binding]; other site 227882009584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882009585 Major Facilitator Superfamily; Region: MFS_1; pfam07690 227882009586 putative substrate translocation pore; other site 227882009587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882009588 putative substrate translocation pore; other site 227882009589 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 227882009590 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 227882009591 Coenzyme A binding pocket [chemical binding]; other site 227882009592 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 227882009593 FAD dependent oxidoreductase; Region: DAO; pfam01266 227882009594 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl10490 227882009595 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 227882009596 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 227882009597 Walker A/P-loop; other site 227882009598 ATP binding site [chemical binding]; other site 227882009599 Q-loop/lid; other site 227882009600 ABC transporter signature motif; other site 227882009601 Walker B; other site 227882009602 D-loop; other site 227882009603 H-loop/switch region; other site 227882009604 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 227882009605 active site 227882009606 Substrate binding site [chemical binding]; other site 227882009607 Mg++ binding site [ion binding]; other site 227882009608 DoxX; Region: DoxX; cl00976 227882009609 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 227882009610 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 227882009611 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 227882009612 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 227882009613 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 227882009614 active site 227882009615 HIGH motif; other site 227882009616 nucleotide binding site [chemical binding]; other site 227882009617 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 227882009618 KMSKS motif; other site 227882009619 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 227882009620 tRNA binding surface [nucleotide binding]; other site 227882009621 anticodon binding site; other site 227882009622 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 227882009623 homotrimer interaction site [polypeptide binding]; other site 227882009624 zinc binding site [ion binding]; other site 227882009625 CDP-binding sites; other site 227882009626 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 227882009627 substrate binding site [chemical binding]; other site 227882009628 dimer interface [polypeptide binding]; other site 227882009629 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 227882009630 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 227882009631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882009632 active site 227882009633 phosphorylation site [posttranslational modification] 227882009634 intermolecular recognition site; other site 227882009635 dimerization interface [polypeptide binding]; other site 227882009636 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882009637 DNA binding site [nucleotide binding] 227882009638 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 227882009639 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 227882009640 dimer interface [polypeptide binding]; other site 227882009641 phosphorylation site [posttranslational modification] 227882009642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882009643 ATP binding site [chemical binding]; other site 227882009644 Mg2+ binding site [ion binding]; other site 227882009645 G-X-G motif; other site 227882009646 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 227882009647 PhoU domain; Region: PhoU; pfam01895 227882009648 PhoU domain; Region: PhoU; pfam01895 227882009649 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 227882009650 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 227882009651 active site 227882009652 catalytic tetrad [active] 227882009653 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 227882009654 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882009655 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 227882009656 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882009657 H+ Antiporter protein; Region: 2A0121; TIGR00900 227882009658 putative substrate translocation pore; other site 227882009659 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 227882009660 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 227882009661 catalytic core [active] 227882009662 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 227882009663 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 227882009664 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 227882009665 DNA binding site [nucleotide binding] 227882009666 Int/Topo IB signature motif; other site 227882009667 active site 227882009668 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 227882009669 Mobile element transfer protein; Region: SpdB; pfam05122 227882009670 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 227882009671 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882009672 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882009673 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 227882009674 DNA-binding site [nucleotide binding]; DNA binding site 227882009675 UTRA domain; Region: UTRA; cl01230 227882009676 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 227882009677 nudix motif; other site 227882009678 Catalytic domain of Protein Kinases; Region: PKc; cd00180 227882009679 active site 227882009680 ATP binding site [chemical binding]; other site 227882009681 substrate binding site [chemical binding]; other site 227882009682 activation loop (A-loop); other site 227882009683 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 227882009684 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 227882009685 Cupin domain; Region: Cupin_2; cl09118 227882009686 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 227882009687 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882009688 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 227882009689 Protein of unknown function (DUF2596); Region: DUF2596; pfam10770 227882009690 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 227882009691 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 227882009692 putative ADP-binding pocket [chemical binding]; other site 227882009693 NlpC/P60 family; Region: NLPC_P60; cl11438 227882009694 Response regulator receiver domain; Region: Response_reg; pfam00072 227882009695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882009696 active site 227882009697 phosphorylation site [posttranslational modification] 227882009698 intermolecular recognition site; other site 227882009699 dimerization interface [polypeptide binding]; other site 227882009700 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882009701 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 227882009702 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 227882009703 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 227882009704 non-specific DNA binding site [nucleotide binding]; other site 227882009705 salt bridge; other site 227882009706 sequence-specific DNA binding site [nucleotide binding]; other site 227882009707 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 227882009708 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 227882009709 FMN binding site [chemical binding]; other site 227882009710 active site 227882009711 substrate binding site [chemical binding]; other site 227882009712 catalytic residue [active] 227882009713 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 227882009714 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 227882009715 DNA binding residues [nucleotide binding] 227882009716 putative dimer interface [polypeptide binding]; other site 227882009717 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 227882009718 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 227882009719 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 227882009720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882009721 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 227882009722 putative NAD(P) binding site [chemical binding]; other site 227882009723 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882009724 active site 227882009725 ATP binding site [chemical binding]; other site 227882009726 substrate binding site [chemical binding]; other site 227882009727 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882009728 active site 227882009729 ATP binding site [chemical binding]; other site 227882009730 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 227882009731 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 227882009732 motif II; other site 227882009733 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 227882009734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882009735 DNA-binding site [nucleotide binding]; DNA binding site 227882009736 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882009737 DNA-binding site [nucleotide binding]; DNA binding site 227882009738 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882009739 L-asparaginase II; Region: Asparaginase_II; cl01842 227882009740 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 227882009741 putative active site [active] 227882009742 dimerization interface [polypeptide binding]; other site 227882009743 putative tRNAtyr binding site [nucleotide binding]; other site 227882009744 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 227882009745 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 227882009746 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 227882009747 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 227882009748 metal binding site 2 [ion binding]; metal-binding site 227882009749 putative DNA binding helix; other site 227882009750 metal binding site 1 [ion binding]; metal-binding site 227882009751 dimer interface [polypeptide binding]; other site 227882009752 structural Zn2+ binding site [ion binding]; other site 227882009753 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 227882009754 heme-binding site [chemical binding]; other site 227882009755 DsrE/DsrF-like family; Region: DrsE; cl00672 227882009756 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 227882009757 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 227882009758 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but...; Region: TST_Repeat_1; cd01448 227882009759 active site residue [active] 227882009760 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 227882009761 active site residue [active] 227882009762 Ubiquitin-like proteins; Region: UBQ; cl00155 227882009763 charged pocket; other site 227882009764 hydrophobic patch; other site 227882009765 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882009766 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882009767 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 227882009768 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882009769 DNA binding site [nucleotide binding] 227882009770 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882009771 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882009772 DNA binding site [nucleotide binding] 227882009773 domain linker motif; other site 227882009774 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 227882009775 dimerization interface [polypeptide binding]; other site 227882009776 ligand binding site [chemical binding]; other site 227882009777 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cd00190 227882009778 cleavage site 227882009779 active site 227882009780 substrate binding sites [chemical binding]; other site 227882009781 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 227882009782 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 227882009783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882009784 active site 227882009785 phosphorylation site [posttranslational modification] 227882009786 intermolecular recognition site; other site 227882009787 dimerization interface [polypeptide binding]; other site 227882009788 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882009789 DNA binding site [nucleotide binding] 227882009790 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882009791 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 227882009792 dimer interface [polypeptide binding]; other site 227882009793 phosphorylation site [posttranslational modification] 227882009794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882009795 ATP binding site [chemical binding]; other site 227882009796 Mg2+ binding site [ion binding]; other site 227882009797 G-X-G motif; other site 227882009798 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882009799 integral membrane protein MviN; Region: mviN; TIGR01695 227882009800 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 227882009801 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 227882009802 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882009803 Walker A/P-loop; other site 227882009804 ATP binding site [chemical binding]; other site 227882009805 Q-loop/lid; other site 227882009806 ABC transporter signature motif; other site 227882009807 Walker B; other site 227882009808 D-loop; other site 227882009809 H-loop/switch region; other site 227882009810 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 227882009811 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 227882009812 putative active site [active] 227882009813 putative metal binding site [ion binding]; other site 227882009814 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 227882009815 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 227882009816 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 227882009817 Coenzyme A binding pocket [chemical binding]; other site 227882009818 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 227882009819 ABC-type multidrug transport system, ATPase component. The biological function of this family is not well characterized, but display ABC domains similar to members of ABCA subfamily. ABC transporters are a large family of proteins involved in the...; Region: ABC_drug_resistance_like; cd03264 227882009820 Walker A/P-loop; other site 227882009821 ATP binding site [chemical binding]; other site 227882009822 Q-loop/lid; other site 227882009823 ABC transporter signature motif; other site 227882009824 Walker B; other site 227882009825 D-loop; other site 227882009826 H-loop/switch region; other site 227882009827 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 227882009828 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882009829 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882009830 Predicted transcriptional regulators [Transcription]; Region: COG1725 227882009831 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882009832 DNA-binding site [nucleotide binding]; DNA binding site 227882009833 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 227882009834 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 227882009835 Walker A/P-loop; other site 227882009836 ATP binding site [chemical binding]; other site 227882009837 Q-loop/lid; other site 227882009838 ABC transporter signature motif; other site 227882009839 Walker B; other site 227882009840 D-loop; other site 227882009841 H-loop/switch region; other site 227882009842 polyphosphate kinase; Provisional; Region: PRK05443 227882009843 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 227882009844 putative domain interface [polypeptide binding]; other site 227882009845 putative active site [active] 227882009846 catalytic site [active] 227882009847 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 227882009848 putative domain interface [polypeptide binding]; other site 227882009849 putative active site [active] 227882009850 catalytic site [active] 227882009851 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 227882009852 active site 227882009853 Ap6A binding site [chemical binding]; other site 227882009854 nudix motif; other site 227882009855 metal binding site [ion binding]; metal-binding site 227882009856 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882009857 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 227882009858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882009859 dimer interface [polypeptide binding]; other site 227882009860 conserved gate region; other site 227882009861 putative PBP binding loops; other site 227882009862 ABC-ATPase subunit interface; other site 227882009863 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 227882009864 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882009865 dimer interface [polypeptide binding]; other site 227882009866 conserved gate region; other site 227882009867 putative PBP binding loops; other site 227882009868 ABC-ATPase subunit interface; other site 227882009869 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 227882009870 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 227882009871 Walker A/P-loop; other site 227882009872 ATP binding site [chemical binding]; other site 227882009873 Q-loop/lid; other site 227882009874 ABC transporter signature motif; other site 227882009875 Walker B; other site 227882009876 D-loop; other site 227882009877 H-loop/switch region; other site 227882009878 Phosphate transporter family; Region: PHO4; cl00396 227882009879 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 227882009880 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 227882009881 putative homotetramer interface [polypeptide binding]; other site 227882009882 putative homodimer interface [polypeptide binding]; other site 227882009883 putative allosteric switch controlling residues; other site 227882009884 putative metal binding site [ion binding]; other site 227882009885 putative homodimer-homodimer interface [polypeptide binding]; other site 227882009886 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 227882009887 FAD binding domain; Region: FAD_binding_4; pfam01565 227882009888 Berberine and berberine like; Region: BBE; pfam08031 227882009889 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 227882009890 active site 227882009891 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 227882009892 N-acetyl-D-glucosamine binding site [chemical binding]; other site 227882009893 catalytic residue [active] 227882009894 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 227882009895 NlpC/P60 family; Region: NLPC_P60; cl11438 227882009896 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882009897 Catalytic domain of Protein Kinases; Region: PKc; cd00180 227882009898 active site 227882009899 ATP binding site [chemical binding]; other site 227882009900 substrate binding site [chemical binding]; other site 227882009901 activation loop (A-loop); other site 227882009902 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882009903 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 227882009904 non-specific DNA binding site [nucleotide binding]; other site 227882009905 salt bridge; other site 227882009906 sequence-specific DNA binding site [nucleotide binding]; other site 227882009907 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882009908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 227882009909 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 227882009910 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 227882009911 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 227882009912 AAA-like domain; Region: AAA_10; pfam12846 227882009913 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 227882009914 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882009915 Transcriptional regulators [Transcription]; Region: MarR; COG1846 227882009916 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882009917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882009918 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882009919 PAS fold; Region: PAS_4; pfam08448 227882009920 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882009921 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 227882009922 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882009923 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 227882009924 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882009925 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 227882009926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882009927 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 227882009928 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 227882009929 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 227882009930 active site 227882009931 catalytic tetrad [active] 227882009932 Peptidase family M23; Region: Peptidase_M23; pfam01551 227882009933 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 227882009934 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 227882009935 catalytic motif [active] 227882009936 Zn binding site [ion binding]; other site 227882009937 Transcriptional regulators [Transcription]; Region: MarR; COG1846 227882009938 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882009939 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 227882009940 dimerization interface [polypeptide binding]; other site 227882009941 active site 227882009942 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882009943 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 227882009944 DEAD-like helicases superfamily; Region: DEXDc; smart00487 227882009945 ATP binding site [chemical binding]; other site 227882009946 Mg++ binding site [ion binding]; other site 227882009947 motif III; other site 227882009948 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 227882009949 nucleotide binding region [chemical binding]; other site 227882009950 ATP-binding site [chemical binding]; other site 227882009951 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 227882009952 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 227882009953 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 227882009954 active site 227882009955 metal binding site [ion binding]; metal-binding site 227882009956 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 227882009957 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 227882009958 ATP binding site [chemical binding]; other site 227882009959 putative Mg++ binding site [ion binding]; other site 227882009960 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 227882009961 nucleotide binding region [chemical binding]; other site 227882009962 ATP-binding site [chemical binding]; other site 227882009963 Helicase associated domain (HA2); Region: HA2; cl04503 227882009964 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 227882009965 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 227882009966 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 227882009967 DNA binding residues [nucleotide binding] 227882009968 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 227882009969 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 227882009970 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 227882009971 NAD binding site [chemical binding]; other site 227882009972 Phe binding site; other site 227882009973 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 227882009974 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 227882009975 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 227882009976 dimerization interface [polypeptide binding]; other site 227882009977 putative ATP binding site [chemical binding]; other site 227882009978 amidophosphoribosyltransferase; Provisional; Region: PRK07847 227882009979 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 227882009980 active site 227882009981 tetramer interface [polypeptide binding]; other site 227882009982 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 227882009983 META domain; Region: META; cl01245 227882009984 META domain; Region: META; cl01245 227882009985 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 227882009986 DinB superfamily; Region: DinB_2; cl00986 227882009987 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 227882009988 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 227882009989 dimerization interface [polypeptide binding]; other site 227882009990 ATP binding site [chemical binding]; other site 227882009991 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 227882009992 dimerization interface [polypeptide binding]; other site 227882009993 ATP binding site [chemical binding]; other site 227882009994 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 227882009995 putative active site [active] 227882009996 catalytic triad [active] 227882009997 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 227882009998 Lsr2; Region: Lsr2; pfam11774 227882009999 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 227882010000 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 227882010001 Walker A/P-loop; other site 227882010002 ATP binding site [chemical binding]; other site 227882010003 Q-loop/lid; other site 227882010004 ABC transporter signature motif; other site 227882010005 Walker B; other site 227882010006 D-loop; other site 227882010007 H-loop/switch region; other site 227882010008 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 227882010009 Histidine kinase; Region: HisKA_3; pfam07730 227882010010 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882010011 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882010012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882010013 active site 227882010014 phosphorylation site [posttranslational modification] 227882010015 intermolecular recognition site; other site 227882010016 dimerization interface [polypeptide binding]; other site 227882010017 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882010018 DNA binding residues [nucleotide binding] 227882010019 dimerization interface [polypeptide binding]; other site 227882010020 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 227882010021 ATP binding site [chemical binding]; other site 227882010022 active site 227882010023 substrate binding site [chemical binding]; other site 227882010024 Peptidase family M48; Region: Peptidase_M48; cl12018 227882010025 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 227882010026 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 227882010027 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 227882010028 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 227882010029 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 227882010030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882010031 Walker A motif; other site 227882010032 ATP binding site [chemical binding]; other site 227882010033 Walker B motif; other site 227882010034 arginine finger; other site 227882010035 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 227882010036 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 227882010037 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 227882010038 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 227882010039 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882010040 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882010041 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 227882010042 Zn binding site [ion binding]; other site 227882010043 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 227882010044 amidase catalytic site [active] 227882010045 Zn binding residues [ion binding]; other site 227882010046 substrate binding site [chemical binding]; other site 227882010047 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 227882010048 DNA-binding site [nucleotide binding]; DNA binding site 227882010049 RNA-binding motif; other site 227882010050 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 227882010051 DEAD-like helicases superfamily; Region: DEXDc; smart00487 227882010052 ATP binding site [chemical binding]; other site 227882010053 Mg++ binding site [ion binding]; other site 227882010054 motif III; other site 227882010055 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 227882010056 nucleotide binding region [chemical binding]; other site 227882010057 ATP-binding site [chemical binding]; other site 227882010058 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 227882010059 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882010060 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 227882010061 dimer interface [polypeptide binding]; other site 227882010062 phosphorylation site [posttranslational modification] 227882010063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882010064 ATP binding site [chemical binding]; other site 227882010065 Mg2+ binding site [ion binding]; other site 227882010066 G-X-G motif; other site 227882010067 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 227882010068 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882010069 active site 227882010070 phosphorylation site [posttranslational modification] 227882010071 intermolecular recognition site; other site 227882010072 dimerization interface [polypeptide binding]; other site 227882010073 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882010074 DNA binding site [nucleotide binding] 227882010075 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 227882010076 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 227882010077 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 227882010078 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 227882010079 Copper resistance protein CopC; Region: CopC; cl01012 227882010080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882010081 NAD(P) binding site [chemical binding]; other site 227882010082 classical (c) SDRs; Region: SDR_c; cd05233 227882010083 active site 227882010084 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 227882010085 Siderophore biosynthesis protein domain; Region: AlcB; cl11000 227882010086 Penicillin amidase; Region: Penicil_amidase; pfam01804 227882010087 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and 7-...; Region: Ntn_PGA_like; cd03747 227882010088 active site 227882010089 uncharacterized HhH-GPD family protein; Region: TIGR03252 227882010090 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 227882010091 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277 227882010092 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 227882010093 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 227882010094 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 227882010095 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 227882010096 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 227882010097 nucleoside/Zn binding site; other site 227882010098 dimer interface [polypeptide binding]; other site 227882010099 catalytic motif [active] 227882010100 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 227882010101 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 227882010102 Phage integrase family; Region: Phage_integrase; pfam00589 227882010103 DNA binding site [nucleotide binding] 227882010104 Int/Topo IB signature motif; other site 227882010105 active site 227882010106 Stress responsive A/B Barrel Domain; Region: Dabb; cl06768 227882010107 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 227882010108 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882010109 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 227882010110 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882010111 DNA binding residues [nucleotide binding] 227882010112 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 227882010113 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882010114 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 227882010115 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882010116 DNA binding residues [nucleotide binding] 227882010117 Transcriptional regulators [Transcription]; Region: MarR; COG1846 227882010118 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882010119 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882010120 Major Facilitator Superfamily; Region: MFS_1; pfam07690 227882010121 putative substrate translocation pore; other site 227882010122 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 227882010123 Collagen-binding protein B domain, mediates bacterial adherence to collagen; the primary sequence has a non-repetitive, collagen-binding A region, followed by the repetitive B region; the B region has one to four 23 kDa repeat units (B1-B4). The B...; Region: CollagenBindB; cl14619 227882010124 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 227882010125 YceI-like domain; Region: YceI; cl01001 227882010126 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 227882010127 tetracycline repressor protein TetR; Provisional; Region: PRK13756 227882010128 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882010129 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 227882010130 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 227882010131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882010132 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 227882010133 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 227882010134 Ligand binding site [chemical binding]; other site 227882010135 Ligand binding site [chemical binding]; other site 227882010136 Ligand binding site [chemical binding]; other site 227882010137 Putative Catalytic site [active] 227882010138 DXD motif; other site 227882010139 GtrA-like protein; Region: GtrA; cl00971 227882010140 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882010141 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 227882010142 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 227882010143 dimer interface [polypeptide binding]; other site 227882010144 phosphorylation site [posttranslational modification] 227882010145 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882010146 Mg2+ binding site [ion binding]; other site 227882010147 G-X-G motif; other site 227882010148 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 227882010149 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882010150 active site 227882010151 phosphorylation site [posttranslational modification] 227882010152 intermolecular recognition site; other site 227882010153 dimerization interface [polypeptide binding]; other site 227882010154 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882010155 DNA binding site [nucleotide binding] 227882010156 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cd01292 227882010157 active site 227882010158 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 227882010159 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 227882010160 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 227882010161 sensory histidine kinase AtoS; Provisional; Region: PRK11360 227882010162 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 227882010163 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 227882010164 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 227882010165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882010166 active site 227882010167 phosphorylation site [posttranslational modification] 227882010168 intermolecular recognition site; other site 227882010169 dimerization interface [polypeptide binding]; other site 227882010170 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882010171 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 227882010172 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 227882010173 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882010174 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882010175 DNA binding residues [nucleotide binding] 227882010176 lipid-transfer protein; Provisional; Region: PRK07855 227882010177 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 227882010178 active site 227882010179 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 227882010180 putative active site [active] 227882010181 putative catalytic site [active] 227882010182 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882010183 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 227882010184 DUF35 OB-fold domain; Region: DUF35; pfam01796 227882010185 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 227882010186 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882010187 active site 227882010188 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 227882010189 nucleotide binding site [chemical binding]; other site 227882010190 polymerase nucleotide-binding site; other site 227882010191 primase nucleotide-binding site [nucleotide binding]; other site 227882010192 DNA-binding residues [nucleotide binding]; DNA binding site 227882010193 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 227882010194 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 227882010195 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 227882010196 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 227882010197 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882010198 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 227882010199 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 227882010200 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 227882010201 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 227882010202 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 227882010203 putative active site [active] 227882010204 catalytic site [active] 227882010205 putative metal binding site [ion binding]; other site 227882010206 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882010207 preprotein translocase subunit SecA; Reviewed; Region: PRK13107 227882010208 SEC-C motif; Region: SEC-C; cl12132 227882010209 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 227882010210 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882010211 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 227882010212 proline aminopeptidase P II; Provisional; Region: PRK10879 227882010213 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action...; Region: Prolidase; cd01087 227882010214 active site 227882010215 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 227882010216 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882010217 DNA-binding site [nucleotide binding]; DNA binding site 227882010218 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 227882010219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882010220 homodimer interface [polypeptide binding]; other site 227882010221 catalytic residue [active] 227882010222 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 227882010223 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 227882010224 putative active site [active] 227882010225 Phosphotransferase enzyme family; Region: APH; pfam01636 227882010226 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 227882010227 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 227882010228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882010229 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 227882010230 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 227882010231 Cu(I) binding site [ion binding]; other site 227882010232 Protein of unknown function (DUF461); Region: DUF461; cl01071 227882010233 Copper resistance protein CopC; Region: CopC; cl01012 227882010234 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 227882010235 prephenate dehydratase; Provisional; Region: PRK11898 227882010236 Prephenate dehydratase; Region: PDT; pfam00800 227882010237 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 227882010238 putative L-Phe binding site [chemical binding]; other site 227882010239 seryl-tRNA synthetase; Provisional; Region: PRK05431 227882010240 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 227882010241 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 227882010242 dimer interface [polypeptide binding]; other site 227882010243 active site 227882010244 motif 1; other site 227882010245 motif 2; other site 227882010246 motif 3; other site 227882010247 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 227882010248 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 227882010249 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882010250 Walker A/P-loop; other site 227882010251 ATP binding site [chemical binding]; other site 227882010252 Q-loop/lid; other site 227882010253 ABC transporter signature motif; other site 227882010254 Walker B; other site 227882010255 D-loop; other site 227882010256 H-loop/switch region; other site 227882010257 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 227882010258 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 227882010259 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 227882010260 Walker A/P-loop; other site 227882010261 ATP binding site [chemical binding]; other site 227882010262 Q-loop/lid; other site 227882010263 ABC transporter signature motif; other site 227882010264 Walker B; other site 227882010265 D-loop; other site 227882010266 H-loop/switch region; other site 227882010267 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cd01066 227882010268 active site 227882010269 short chain dehydrogenase; Validated; Region: PRK05855 227882010270 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882010271 classical (c) SDRs; Region: SDR_c; cd05233 227882010272 NAD(P) binding site [chemical binding]; other site 227882010273 active site 227882010274 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 227882010275 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 227882010276 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 227882010277 DNA binding residues [nucleotide binding] 227882010278 putative dimer interface [polypeptide binding]; other site 227882010279 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 227882010280 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882010281 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 227882010282 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 227882010283 active site 227882010284 motif I; other site 227882010285 motif II; other site 227882010286 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882010287 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882010288 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 227882010289 GAF domain; Region: GAF; cl00853 227882010290 GAF domain; Region: GAF; cl00853 227882010291 Histidine kinase; Region: HisKA_3; pfam07730 227882010292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882010293 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 227882010294 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 227882010295 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882010296 Walker A/P-loop; other site 227882010297 ATP binding site [chemical binding]; other site 227882010298 Q-loop/lid; other site 227882010299 ABC transporter signature motif; other site 227882010300 Walker B; other site 227882010301 D-loop; other site 227882010302 H-loop/switch region; other site 227882010303 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 227882010304 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882010305 Walker A/P-loop; other site 227882010306 ATP binding site [chemical binding]; other site 227882010307 Q-loop/lid; other site 227882010308 ABC transporter signature motif; other site 227882010309 Walker B; other site 227882010310 D-loop; other site 227882010311 H-loop/switch region; other site 227882010312 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 227882010313 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 227882010314 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 227882010315 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 227882010316 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 227882010317 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 227882010318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882010319 homodimer interface [polypeptide binding]; other site 227882010320 catalytic residue [active] 227882010321 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882010322 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882010323 DNA binding site [nucleotide binding] 227882010324 domain linker motif; other site 227882010325 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 227882010326 ligand binding site [chemical binding]; other site 227882010327 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 227882010328 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 227882010329 active site 227882010330 metal binding site [ion binding]; metal-binding site 227882010331 ThiC family; Region: ThiC; cl08031 227882010332 YibE/F-like protein; Region: YibE_F; cl02259 227882010333 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 227882010334 Transcriptional regulator [Transcription]; Region: IclR; COG1414 227882010335 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882010336 Bacterial transcriptional regulator; Region: IclR; pfam01614 227882010337 Cupin domain; Region: Cupin_2; cl09118 227882010338 Membrane protein of unknown function; Region: DUF360; cl00850 227882010339 Low molecular weight phosphatase family; Region: LMWPc; cd00115 227882010340 Active site [active] 227882010341 cystathionine gamma-lyase; Validated; Region: PRK07582 227882010342 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 227882010343 homodimer interface [polypeptide binding]; other site 227882010344 substrate-cofactor binding pocket; other site 227882010345 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882010346 catalytic residue [active] 227882010347 Transcriptional regulator [Transcription]; Region: LysR; COG0583 227882010348 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882010349 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882010350 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 227882010351 nudix motif; other site 227882010352 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 227882010353 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 227882010354 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 227882010355 heme-binding site [chemical binding]; other site 227882010356 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 227882010357 FAD binding pocket [chemical binding]; other site 227882010358 FAD binding motif [chemical binding]; other site 227882010359 phosphate binding motif [ion binding]; other site 227882010360 beta-alpha-beta structure motif; other site 227882010361 NAD binding pocket [chemical binding]; other site 227882010362 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 227882010363 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882010364 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 227882010365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882010366 Domain of unknown function (DUF336); Region: DUF336; cl01249 227882010367 Major Facilitator Superfamily; Region: MFS_1; pfam07690 227882010368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882010369 putative substrate translocation pore; other site 227882010370 Transcriptional regulators [Transcription]; Region: MarR; COG1846 227882010371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882010372 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 227882010373 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 227882010374 Coenzyme A binding pocket [chemical binding]; other site 227882010375 Beta-lactamase; Region: Beta-lactamase; cl01009 227882010376 replicative DNA helicase; Region: DnaB; TIGR00665 227882010377 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 227882010378 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 227882010379 Walker A motif; other site 227882010380 ATP binding site [chemical binding]; other site 227882010381 Walker B motif; other site 227882010382 DNA binding loops [nucleotide binding] 227882010383 putative efflux protein, MATE family; Region: matE; TIGR00797 227882010384 MatE; Region: MatE; cl10513 227882010385 MatE; Region: MatE; cl10513 227882010386 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 227882010387 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 227882010388 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 227882010389 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 227882010390 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 227882010391 dimer interface [polypeptide binding]; other site 227882010392 ssDNA binding site [nucleotide binding]; other site 227882010393 tetramer (dimer of dimers) interface [polypeptide binding]; other site 227882010394 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 227882010395 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 227882010396 FemAB family; Region: FemAB; cl11444 227882010397 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 227882010398 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 227882010399 catalytic residue [active] 227882010400 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 227882010401 Transglycosylase; Region: Transgly; cl07896 227882010402 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 227882010403 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 227882010404 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882010405 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 227882010406 Myo-inositol-1-phosphate synthase; Region: Inos-1-P_synth; cl00554 227882010407 H+ Antiporter protein; Region: 2A0121; TIGR00900 227882010408 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 227882010409 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 227882010410 active site 227882010411 NTP binding site [chemical binding]; other site 227882010412 metal binding triad [ion binding]; metal-binding site 227882010413 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 227882010414 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 227882010415 Zn2+ binding site [ion binding]; other site 227882010416 Mg2+ binding site [ion binding]; other site 227882010417 integral membrane protein MviN; Region: mviN; TIGR01695 227882010418 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882010419 active site 227882010420 ATP binding site [chemical binding]; other site 227882010421 substrate binding site [chemical binding]; other site 227882010422 activation loop (A-loop); other site 227882010423 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 227882010424 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882010425 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882010426 DNA binding residues [nucleotide binding] 227882010427 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl11829 227882010428 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 227882010429 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882010430 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882010431 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 227882010432 catalytic residues [active] 227882010433 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882010434 ParB-like partition proteins; Region: parB_part; TIGR00180 227882010435 ParB-like nuclease domain; Region: ParBc; cl02129 227882010436 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 227882010437 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 227882010438 P-loop; other site 227882010439 Magnesium ion binding site [ion binding]; other site 227882010440 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 227882010441 Magnesium ion binding site [ion binding]; other site 227882010442 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 227882010443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882010444 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 227882010445 G-X-X-G motif; other site 227882010446 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 227882010447 RxxxH motif; other site 227882010448 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 227882010449 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 227882010450 Domain of unknown function DUF37; Region: DUF37; cl00506 227882010451 Ribonuclease P; Region: Ribonuclease_P; cl00457 227882010452 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 227882010453 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 227882010454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882010455 Walker A motif; other site 227882010456 ATP binding site [chemical binding]; other site 227882010457 Walker B motif; other site 227882010458 arginine finger; other site 227882010459 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 227882010460 DnaA box-binding interface [nucleotide binding]; other site 227882010461 DNA polymerase III subunit beta; Validated; Region: PRK07761 227882010462 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 227882010463 putative DNA binding surface [nucleotide binding]; other site 227882010464 dimer interface [polypeptide binding]; other site 227882010465 beta-clamp/clamp loader binding surface; other site 227882010466 beta-clamp/translesion DNA polymerase binding surface; other site 227882010467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882010468 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 227882010469 recombination protein F; Reviewed; Region: recF; PRK00064 227882010470 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 227882010471 Walker A/P-loop; other site 227882010472 ATP binding site [chemical binding]; other site 227882010473 Q-loop/lid; other site 227882010474 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882010475 ABC transporter signature motif; other site 227882010476 Walker B; other site 227882010477 D-loop; other site 227882010478 H-loop/switch region; other site 227882010479 Protein of unknown function (DUF721); Region: DUF721; cl02324 227882010480 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 227882010481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882010482 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 227882010483 anchoring element; other site 227882010484 dimer interface [polypeptide binding]; other site 227882010485 ATP binding site [chemical binding]; other site 227882010486 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 227882010487 active site 227882010488 putative metal-binding site [ion binding]; other site 227882010489 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 227882010490 DNA gyrase subunit A; Validated; Region: PRK05560 227882010491 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 227882010492 CAP-like domain; other site 227882010493 Active site [active] 227882010494 primary dimer interface [polypeptide binding]; other site 227882010495 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 227882010496 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 227882010497 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 227882010498 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 227882010499 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 227882010500 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 227882010501 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 227882010502 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882010503 Catalytic domain of Protein Kinases; Region: PKc; cd00180 227882010504 active site 227882010505 ATP binding site [chemical binding]; other site 227882010506 substrate binding site [chemical binding]; other site 227882010507 activation loop (A-loop); other site 227882010508 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882010509 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 227882010510 active site 227882010511 Rhomboid family; Region: Rhomboid; cl11446 227882010512 Uncharacterised protein family (UPF0233); Region: UPF0233; cl11506 227882010513 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 227882010514 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase_D_5; cd05830 227882010515 active site 227882010516 catalytic site [active] 227882010517 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 227882010518 Glutamine amidotransferase class-I; Region: GATase; pfam00117 227882010519 glutamine binding [chemical binding]; other site 227882010520 catalytic triad [active] 227882010521 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase_D_5; cd05830 227882010522 active site 227882010523 catalytic site [active] 227882010524 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase_D_5; cd05830 227882010525 active site 227882010526 catalytic site [active] 227882010527 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882010528 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882010529 active site 227882010530 ATP binding site [chemical binding]; other site 227882010531 substrate binding site [chemical binding]; other site 227882010532 activation loop (A-loop); other site 227882010533 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 227882010534 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 227882010535 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 227882010536 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 227882010537 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 227882010538 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 227882010539 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 227882010540 Protein phosphatase 2C; Region: PP2C; pfam00481 227882010541 Active site [active] 227882010542 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 227882010543 phosphopeptide binding site; other site 227882010544 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 227882010545 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 227882010546 phosphopeptide binding site; other site 227882010547 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 227882010548 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882010549 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 227882010550 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 227882010551 HSP70 interaction site [polypeptide binding]; other site 227882010552 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 227882010553 active site residue [active] 227882010554 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882010555 active site 227882010556 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 227882010557 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-...; Region: PA_degradation_oxidoreductase_like; cd06214 227882010558 FAD binding pocket [chemical binding]; other site 227882010559 FAD binding motif [chemical binding]; other site 227882010560 phosphate binding motif [ion binding]; other site 227882010561 beta-alpha-beta structure motif; other site 227882010562 NAD(p) ribose binding residues [chemical binding]; other site 227882010563 NAD binding pocket [chemical binding]; other site 227882010564 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 227882010565 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 227882010566 catalytic loop [active] 227882010567 iron binding site [ion binding]; other site 227882010568 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 227882010569 Domain of unknown function DUF59; Region: DUF59; cl00941 227882010570 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 227882010571 Phenylacetic acid degradation B; Region: PaaB; cl01371 227882010572 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 227882010573 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 227882010574 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 227882010575 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 227882010576 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 227882010577 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 227882010578 Phenylacetic acid degradation proteins PaaZ (Escherichia coli) and PaaN (Pseudomonas putida)-like; Region: ALDH_PAD-PaaZ; cd07127 227882010579 NADP binding site [chemical binding]; other site 227882010580 catalytic residues [active] 227882010581 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 227882010582 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 227882010583 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 227882010584 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 227882010585 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882010586 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882010587 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882010588 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882010589 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 227882010590 tetramer interface [polypeptide binding]; other site 227882010591 TPP-binding site [chemical binding]; other site 227882010592 heterodimer interface [polypeptide binding]; other site 227882010593 phosphorylation loop region [posttranslational modification] 227882010594 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 227882010595 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 227882010596 alpha subunit interface [polypeptide binding]; other site 227882010597 TPP binding site [chemical binding]; other site 227882010598 heterodimer interface [polypeptide binding]; other site 227882010599 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 227882010600 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 227882010601 E3 interaction surface; other site 227882010602 lipoyl attachment site [posttranslational modification]; other site 227882010603 e3 binding domain; Region: E3_binding; pfam02817 227882010604 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 227882010605 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 227882010606 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 227882010607 GTP binding site [chemical binding]; other site 227882010608 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 227882010609 dimer interface [polypeptide binding]; other site 227882010610 putative functional site; other site 227882010611 putative MPT binding site; other site 227882010612 Ion channel; Region: Ion_trans_2; cl11596 227882010613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882010614 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 227882010615 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 227882010616 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 227882010617 NAD(P) binding site [chemical binding]; other site 227882010618 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 227882010619 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882010620 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882010621 active site 227882010622 ATP binding site [chemical binding]; other site 227882010623 substrate binding site [chemical binding]; other site 227882010624 activation loop (A-loop); other site 227882010625 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 227882010626 Protein kinase domain; Region: Pkinase; pfam00069 227882010627 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882010628 active site 227882010629 ATP binding site [chemical binding]; other site 227882010630 substrate binding site [chemical binding]; other site 227882010631 activation loop (A-loop); other site 227882010632 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882010633 active site 227882010634 substrate binding site [chemical binding]; other site 227882010635 ATP binding site [chemical binding]; other site 227882010636 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 227882010637 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882010638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882010639 active site 227882010640 phosphorylation site [posttranslational modification] 227882010641 intermolecular recognition site; other site 227882010642 dimerization interface [polypeptide binding]; other site 227882010643 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882010644 DNA binding residues [nucleotide binding] 227882010645 dimerization interface [polypeptide binding]; other site 227882010646 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 227882010647 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 227882010648 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 227882010649 TPP-binding site [chemical binding]; other site 227882010650 tetramer interface [polypeptide binding]; other site 227882010651 heterodimer interface [polypeptide binding]; other site 227882010652 phosphorylation loop region [posttranslational modification] 227882010653 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 227882010654 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 227882010655 alpha subunit interface [polypeptide binding]; other site 227882010656 TPP binding site [chemical binding]; other site 227882010657 heterodimer interface [polypeptide binding]; other site 227882010658 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 227882010659 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 227882010660 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 227882010661 E3 interaction surface; other site 227882010662 lipoyl attachment site [posttranslational modification]; other site 227882010663 e3 binding domain; Region: E3_binding; pfam02817 227882010664 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 227882010665 Beta-lactamase; Region: Beta-lactamase; cl01009 227882010666 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 227882010667 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882010668 FCD domain; Region: FCD; cl11656 227882010669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882010670 Major Facilitator Superfamily; Region: MFS_1; pfam07690 227882010671 putative substrate translocation pore; other site 227882010672 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 227882010673 DinB superfamily; Region: DinB_2; cl00986 227882010674 SCP-2 sterol transfer family; Region: SCP2; cl01225 227882010675 Predicted amidohydrolase [General function prediction only]; Region: COG0388 227882010676 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 227882010677 putative active site [active] 227882010678 catalytic triad [active] 227882010679 putative dimer interface [polypeptide binding]; other site 227882010680 Scramblase; Region: Scramblase; cl02043 227882010681 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 227882010682 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 227882010683 catalytic residues [active] 227882010684 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 227882010685 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 227882010686 active site 227882010687 metal binding site [ion binding]; metal-binding site 227882010688 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 227882010689 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 227882010690 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 227882010691 FAD binding site [chemical binding]; other site 227882010692 substrate binding site [chemical binding]; other site 227882010693 catalytic residues [active] 227882010694 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 227882010695 Pirin-related protein [General function prediction only]; Region: COG1741 227882010696 Cupin domain; Region: Cupin_2; cl09118 227882010697 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 227882010698 37-bp 227882010699 Domain of unknown function DUF20; Region: UPF0118; cl00465 227882010700 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 227882010701 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882010702 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882010703 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882010704 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 227882010705 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 227882010706 dimer interface [polypeptide binding]; other site 227882010707 anticodon binding site; other site 227882010708 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 227882010709 homodimer interface [polypeptide binding]; other site 227882010710 motif 1; other site 227882010711 active site 227882010712 motif 2; other site 227882010713 GAD domain; Region: GAD; pfam02938 227882010714 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 227882010715 active site 227882010716 motif 3; other site 227882010717 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 227882010718 putative active site [active] 227882010719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882010720 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882010721 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 227882010722 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882010723 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 227882010724 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 227882010725 active site 227882010726 HIGH motif; other site 227882010727 KMSKS motif; other site 227882010728 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 227882010729 tRNA binding surface [nucleotide binding]; other site 227882010730 anticodon binding site; other site 227882010731 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 227882010732 metal ion-dependent adhesion site (MIDAS); other site 227882010733 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 227882010734 Transcriptional regulator [Transcription]; Region: LysR; COG0583 227882010735 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882010736 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 227882010737 dimerization interface [polypeptide binding]; other site 227882010738 substrate binding pocket [chemical binding]; other site 227882010739 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 227882010740 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 227882010741 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 227882010742 putative catalytic site [active] 227882010743 putative metal binding site [ion binding]; other site 227882010744 putative phosphate binding site [ion binding]; other site 227882010745 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882010746 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 227882010747 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882010748 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882010749 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 227882010750 catalytic residue [active] 227882010751 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882010752 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 227882010753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882010754 active site 227882010755 phosphorylation site [posttranslational modification] 227882010756 intermolecular recognition site; other site 227882010757 dimerization interface [polypeptide binding]; other site 227882010758 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882010759 DNA binding site [nucleotide binding] 227882010760 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 227882010761 dimer interface [polypeptide binding]; other site 227882010762 phosphorylation site [posttranslational modification] 227882010763 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882010764 ATP binding site [chemical binding]; other site 227882010765 Mg2+ binding site [ion binding]; other site 227882010766 G-X-G motif; other site 227882010767 Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897 227882010768 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882010769 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 227882010770 Transglycosylase; Region: Transgly; cl07896 227882010771 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 227882010772 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 227882010773 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882010774 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 227882010775 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 227882010776 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882010777 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882010778 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 227882010779 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 227882010780 RES domain; Region: RES; cl02411 227882010781 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 227882010782 structural tetrad; other site 227882010783 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 227882010784 structural tetrad; other site 227882010785 Predicted outer membrane protein [Function unknown]; Region: COG3652 227882010786 Predicted permease; Region: DUF318; cl00487 227882010787 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 227882010788 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 227882010789 Integrase core domain; Region: rve; cl01316 227882010790 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 227882010791 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 227882010792 active site 227882010793 motif I; other site 227882010794 motif II; other site 227882010795 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882010796 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882010797 DEAD-like helicases superfamily; Region: DEXDc; smart00487 227882010798 ATP binding site [chemical binding]; other site 227882010799 putative Mg++ binding site [ion binding]; other site 227882010800 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 227882010801 nucleotide binding region [chemical binding]; other site 227882010802 ATP-binding site [chemical binding]; other site 227882010803 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 227882010804 DNA-binding site [nucleotide binding]; DNA binding site 227882010805 RNA-binding motif; other site 227882010806 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 227882010807 DNA binding residues [nucleotide binding] 227882010808 Beta-lactamase; Region: Beta-lactamase; cl01009 227882010809 Histidine kinase; Region: HisKA_3; pfam07730 227882010810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882010811 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882010812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882010813 active site 227882010814 phosphorylation site [posttranslational modification] 227882010815 intermolecular recognition site; other site 227882010816 dimerization interface [polypeptide binding]; other site 227882010817 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882010818 DNA binding residues [nucleotide binding] 227882010819 dimerization interface [polypeptide binding]; other site 227882010820 Beta-lactamase; Region: Beta-lactamase; cl01009 227882010821 Protein of unknown function (DUF1152); Region: DUF1152; pfam06626 227882010822 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4034 227882010823 Lysyl oxidase; Region: Lysyl_oxidase; pfam01186 227882010824 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 227882010825 N-acetyl-D-glucosamine binding site [chemical binding]; other site 227882010826 catalytic residue [active] 227882010827 NlpC/P60 family; Region: NLPC_P60; cl11438 227882010828 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 227882010829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882010830 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 227882010831 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882010832 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 227882010833 DXD motif; other site 227882010834 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 227882010835 trimer interface [polypeptide binding]; other site 227882010836 active site 227882010837 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 227882010838 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 227882010839 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 227882010840 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 227882010841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882010842 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 227882010843 catalytic residues [active] 227882010844 catalytic nucleophile [active] 227882010845 Recombinase; Region: Recombinase; pfam07508 227882010846 Yip1 domain; Region: Yip1; cl12048 227882010847 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882010848 FG-GAP repeat; Region: FG-GAP; cl15299 227882010849 FG-GAP repeat; Region: FG-GAP; cl15299 227882010850 FG-GAP repeat; Region: FG-GAP; cl15299 227882010851 FG-GAP repeat; Region: FG-GAP; cl15299 227882010852 FG-GAP repeat; Region: FG-GAP; cl15299 227882010853 FG-GAP repeat; Region: FG-GAP; cl15299 227882010854 FG-GAP repeat; Region: FG-GAP; cl15299 227882010855 FG-GAP repeat; Region: FG-GAP; cl15299 227882010856 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 227882010857 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 227882010858 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 227882010859 Cysteine-rich domain; Region: CCG; pfam02754 227882010860 Cysteine-rich domain; Region: CCG; pfam02754 227882010861 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 227882010862 Mg++ binding site [ion binding]; other site 227882010863 putative catalytic motif [active] 227882010864 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 227882010865 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 227882010866 dimer interface [polypeptide binding]; other site 227882010867 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 227882010868 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 227882010869 HSP70 interaction site [polypeptide binding]; other site 227882010870 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 227882010871 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 227882010872 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 227882010873 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 227882010874 DNA binding residues [nucleotide binding] 227882010875 putative dimer interface [polypeptide binding]; other site 227882010876 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 227882010877 putative ligand binding site [chemical binding]; other site 227882010878 AAA-like domain; Region: AAA_10; pfam12846 227882010879 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 227882010880 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 227882010881 N-acetyl-D-glucosamine binding site [chemical binding]; other site 227882010882 catalytic residue [active] 227882010883 Peptidase family M23; Region: Peptidase_M23; pfam01551 227882010884 NlpC/P60 family; Region: NLPC_P60; cl11438 227882010885 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882010886 Walker A motif; other site 227882010887 ATP binding site [chemical binding]; other site 227882010888 Walker B motif; other site 227882010889 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882010890 DNA binding residues [nucleotide binding] 227882010891 dimerization interface [polypeptide binding]; other site 227882010892 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 227882010893 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882010894 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 227882010895 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 227882010896 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882010897 Walker A motif; other site 227882010898 ATP binding site [chemical binding]; other site 227882010899 Walker B motif; other site 227882010900 arginine finger; other site 227882010901 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882010902 Walker A motif; other site 227882010903 ATP binding site [chemical binding]; other site 227882010904 Walker B motif; other site 227882010905 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 227882010906 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; cl02342 227882010907 hypothetical protein; Provisional; Region: PRK08912 227882010908 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 227882010909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882010910 homodimer interface [polypeptide binding]; other site 227882010911 catalytic residue [active] 227882010912 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 227882010913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882010914 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 227882010915 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 227882010916 putative hydrophobic ligand binding site [chemical binding]; other site 227882010917 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 227882010918 active site 227882010919 catalytic residues [active] 227882010920 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 227882010921 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 227882010922 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 227882010923 active site 227882010924 intersubunit interface [polypeptide binding]; other site 227882010925 zinc binding site [ion binding]; other site 227882010926 Na+ binding site [ion binding]; other site 227882010927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882010928 putative substrate translocation pore; other site 227882010929 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 227882010930 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 227882010931 kynureninase; Region: kynureninase; TIGR01814 227882010932 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882010933 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 227882010934 catalytic residue [active] 227882010935 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 227882010936 phosphopeptide binding site; other site 227882010937 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882010938 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882010939 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882010940 Alpha/beta hydrolase of unknown function (DUF1023); Region: DUF1023; pfam06259 227882010941 Acyltransferase family; Region: Acyl_transf_3; pfam01757 227882010942 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 227882010943 Histidine kinase; Region: HisKA_3; pfam07730 227882010944 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882010945 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882010946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882010947 active site 227882010948 phosphorylation site [posttranslational modification] 227882010949 intermolecular recognition site; other site 227882010950 dimerization interface [polypeptide binding]; other site 227882010951 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882010952 DNA binding residues [nucleotide binding] 227882010953 dimerization interface [polypeptide binding]; other site 227882010954 Histidine kinase; Region: HisKA_3; pfam07730 227882010955 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882010956 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882010957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882010958 active site 227882010959 phosphorylation site [posttranslational modification] 227882010960 intermolecular recognition site; other site 227882010961 dimerization interface [polypeptide binding]; other site 227882010962 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882010963 dimerization interface [polypeptide binding]; other site 227882010964 DNA binding residues [nucleotide binding] 227882010965 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882010966 Cytochrome P450; Region: p450; cl12078 227882010967 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 227882010968 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 227882010969 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 227882010970 Walker A/P-loop; other site 227882010971 ATP binding site [chemical binding]; other site 227882010972 Q-loop/lid; other site 227882010973 ABC transporter signature motif; other site 227882010974 Walker B; other site 227882010975 D-loop; other site 227882010976 H-loop/switch region; other site 227882010977 Amino acid permease; Region: AA_permease; pfam00324 227882010978 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882010979 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 227882010980 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; cl09205 227882010981 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 227882010982 adenylosuccinate synthetase; Provisional; Region: PRK01117 227882010983 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 227882010984 GDP-binding site [chemical binding]; other site 227882010985 ACT binding site; other site 227882010986 IMP binding site; other site 227882010987 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 227882010988 Ligand binding site [chemical binding]; other site 227882010989 Ligand binding site [chemical binding]; other site 227882010990 Ligand binding site [chemical binding]; other site 227882010991 Putative Catalytic site [active] 227882010992 DXD motif; other site 227882010993 Transcriptional regulators [Transcription]; Region: GntR; COG1802 227882010994 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882010995 DNA-binding site [nucleotide binding]; DNA binding site 227882010996 FCD domain; Region: FCD; cl11656 227882010997 hypothetical protein; Provisional; Region: PRK06062 227882010998 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 227882010999 inhibitor-cofactor binding pocket; inhibition site 227882011000 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882011001 catalytic residue [active] 227882011002 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 227882011003 conserved cys residue [active] 227882011004 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882011005 Catalytic domain of Protein Kinases; Region: PKc; cd00180 227882011006 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882011007 active site 227882011008 ATP binding site [chemical binding]; other site 227882011009 substrate binding site [chemical binding]; other site 227882011010 activation loop (A-loop); other site 227882011011 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 227882011012 recombination protein RecR; Reviewed; Region: recR; PRK00076 227882011013 RecR protein; Region: RecR; pfam02132 227882011014 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 227882011015 putative active site [active] 227882011016 putative metal-binding site [ion binding]; other site 227882011017 tetramer interface [polypeptide binding]; other site 227882011018 aspartate kinase; Reviewed; Region: PRK06635 227882011019 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 227882011020 putative nucleotide binding site [chemical binding]; other site 227882011021 putative catalytic residues [active] 227882011022 putative Mg ion binding site [ion binding]; other site 227882011023 putative aspartate binding site [chemical binding]; other site 227882011024 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 227882011025 putative allosteric regulatory site; other site 227882011026 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 227882011027 putative allosteric regulatory residue; other site 227882011028 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 227882011029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882011030 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 227882011031 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 227882011032 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882011033 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 227882011034 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 227882011035 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 227882011036 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 227882011037 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 227882011038 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882011039 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882011040 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882011041 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 227882011042 Predicted permease; Region: DUF318; cl00487 227882011043 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 227882011044 Moco binding site; other site 227882011045 metal coordination site [ion binding]; other site 227882011046 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 227882011047 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 227882011048 Ligand binding site [chemical binding]; other site 227882011049 Putative Catalytic site [active] 227882011050 DXD motif; other site 227882011051 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 227882011052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882011053 NAD(P) binding site [chemical binding]; other site 227882011054 active site 227882011055 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 227882011056 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 227882011057 active site 227882011058 catalytic residues [active] 227882011059 Alpha/beta hydrolase of unknown function (DUF1023); Region: DUF1023; pfam06259 227882011060 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 227882011061 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 227882011062 putative active site [active] 227882011063 putative metal binding site [ion binding]; other site 227882011064 GatB domain; Region: GatB_Yqey; cl11497 227882011065 Transglycosylase; Region: Transgly; cl07896 227882011066 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 227882011067 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 227882011068 Transcription factor WhiB; Region: Whib; pfam02467 227882011069 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 227882011070 DTAP/Switch II; other site 227882011071 Switch I; other site 227882011072 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 227882011073 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 227882011074 DTAP/Switch II; other site 227882011075 Switch I; other site 227882011076 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 227882011077 homotrimer interaction site [polypeptide binding]; other site 227882011078 putative active site [active] 227882011079 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 227882011080 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 227882011081 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 227882011082 ligand binding site [chemical binding]; other site 227882011083 flexible hinge region; other site 227882011084 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882011085 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 227882011086 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 227882011087 minor groove reading motif; other site 227882011088 helix-hairpin-helix signature motif; other site 227882011089 substrate binding pocket [chemical binding]; other site 227882011090 active site 227882011091 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 227882011092 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 227882011093 putative active site [active] 227882011094 putative CoA binding site [chemical binding]; other site 227882011095 nudix motif; other site 227882011096 metal binding site [ion binding]; metal-binding site 227882011097 Colicin V production protein; Region: Colicin_V; cl00567 227882011098 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 227882011099 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882011100 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 227882011101 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 227882011102 acetyl-CoA synthetase; Provisional; Region: PRK00174 227882011103 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 227882011104 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882011105 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882011106 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 227882011107 Sulfate transporter family; Region: Sulfate_transp; cl00967 227882011108 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 227882011109 Sulfate transporter family; Region: Sulfate_transp; cl00967 227882011110 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 227882011111 active site clefts [active] 227882011112 zinc binding site [ion binding]; other site 227882011113 dimer interface [polypeptide binding]; other site 227882011114 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 227882011115 Fic family protein [Function unknown]; Region: COG3177 227882011116 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 227882011117 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882011118 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 227882011119 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 227882011120 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882011121 Walker A motif; other site 227882011122 ATP binding site [chemical binding]; other site 227882011123 Walker B motif; other site 227882011124 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 227882011125 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 227882011126 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882011127 ATP binding site [chemical binding]; other site 227882011128 putative Mg++ binding site [ion binding]; other site 227882011129 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882011130 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 227882011131 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 227882011132 anti sigma factor interaction site; other site 227882011133 regulatory phosphorylation site [posttranslational modification]; other site 227882011134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882011135 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 227882011136 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 227882011137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882011138 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882011139 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882011140 active site 227882011141 ATP binding site [chemical binding]; other site 227882011142 substrate binding site [chemical binding]; other site 227882011143 activation loop (A-loop); other site 227882011144 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 227882011145 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 227882011146 active site 227882011147 interdomain interaction site; other site 227882011148 putative metal-binding site [ion binding]; other site 227882011149 nucleotide binding site [chemical binding]; other site 227882011150 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cl11986 227882011151 domain I; other site 227882011152 phosphate binding site [ion binding]; other site 227882011153 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 227882011154 domain II; other site 227882011155 domain III; other site 227882011156 nucleotide binding site [chemical binding]; other site 227882011157 DNA binding groove [nucleotide binding] 227882011158 catalytic site [active] 227882011159 domain IV; other site 227882011160 thymidylate kinase; Validated; Region: tmk; PRK00698 227882011161 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 227882011162 TMP-binding site; other site 227882011163 ATP-binding site [chemical binding]; other site 227882011164 DNA polymerase III subunit delta'; Validated; Region: PRK07940 227882011165 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882011166 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 227882011167 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882011168 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 227882011169 Int/Topo IB signature motif; other site 227882011170 DNA binding site [nucleotide binding] 227882011171 active site 227882011172 GAF domain; Region: GAF; cl00853 227882011173 ANTAR domain; Region: ANTAR; cl04297 227882011174 ANTAR domain; Region: ANTAR; cl04297 227882011175 ANTAR domain; Region: ANTAR; cl04297 227882011176 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 227882011177 active site 227882011178 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882011179 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 227882011180 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 227882011181 TPR motif; other site 227882011182 binding surface 227882011183 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 227882011184 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 227882011185 active site 227882011186 DNA binding site [nucleotide binding] 227882011187 catalytic site [active] 227882011188 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 227882011189 Clp amino terminal domain; Region: Clp_N; pfam02861 227882011190 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 227882011191 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 227882011192 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 227882011193 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 227882011194 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 227882011195 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 227882011196 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 227882011197 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 227882011198 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 227882011199 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882011200 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882011201 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882011202 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 227882011203 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 227882011204 NAD(P) binding site [chemical binding]; other site 227882011205 catalytic residues [active] 227882011206 DinB superfamily; Region: DinB_2; cl00986 227882011207 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882011208 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882011209 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 227882011210 Walker A/P-loop; other site 227882011211 ATP binding site [chemical binding]; other site 227882011212 Q-loop/lid; other site 227882011213 ABC transporter signature motif; other site 227882011214 Walker B; other site 227882011215 D-loop; other site 227882011216 H-loop/switch region; other site 227882011217 ABC-2 type transporter; Region: ABC2_membrane; cl11417 227882011218 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 227882011219 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 227882011220 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882011221 catalytic residue [active] 227882011222 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 227882011223 Cl- selectivity filter; other site 227882011224 Cl- binding residues [ion binding]; other site 227882011225 pore gating glutamate residue; other site 227882011226 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 227882011227 DNA binding residues [nucleotide binding] 227882011228 Cd(II)/Pb(II)-responsive transcriptional regulator; Region: CadR-PbrR; TIGR02047 227882011229 dimer interface [polypeptide binding]; other site 227882011230 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 227882011231 Domain of unknown function (DUF74); Region: DUF74; cl00426 227882011232 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 227882011233 Uncharacterized conserved protein [Function unknown]; Region: COG2966 227882011234 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 227882011235 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 227882011236 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 227882011237 dimer interface [polypeptide binding]; other site 227882011238 substrate binding site [chemical binding]; other site 227882011239 metal binding sites [ion binding]; metal-binding site 227882011240 PBP4 family; Region: PBP4; TIGR00666 227882011241 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 227882011242 Uncharacterised conserved protein (DUF2342); Region: DUF2342; cl02183 227882011243 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 227882011244 Ligand Binding Site [chemical binding]; other site 227882011245 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 227882011246 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 227882011247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882011248 Walker A motif; other site 227882011249 ATP binding site [chemical binding]; other site 227882011250 Walker B motif; other site 227882011251 arginine finger; other site 227882011252 Peptidase family M41; Region: Peptidase_M41; pfam01434 227882011253 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 227882011254 homodecamer interface [polypeptide binding]; other site 227882011255 GTP cyclohydrolase I; Provisional; Region: PLN03044 227882011256 active site 227882011257 putative catalytic site residues [active] 227882011258 zinc binding site [ion binding]; other site 227882011259 GTP-CH-I/GFRP interaction surface; other site 227882011260 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 227882011261 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 227882011262 catalytic center binding site [active] 227882011263 ATP binding site [chemical binding]; other site 227882011264 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines...; Region: DHNA_DHNTPE; cd00534 227882011265 homooctamer interface [polypeptide binding]; other site 227882011266 active site 227882011267 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 227882011268 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 227882011269 dihydropteroate synthase; Region: DHPS; TIGR01496 227882011270 substrate binding pocket [chemical binding]; other site 227882011271 dimer interface [polypeptide binding]; other site 227882011272 inhibitor binding site; inhibition site 227882011273 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 227882011274 Predicted esterase [General function prediction only]; Region: COG0627 227882011275 Predicted membrane protein [Function unknown]; Region: COG3428 227882011276 Bacterial membrane flanked domain; Region: DUF304; cl01348 227882011277 Bacterial membrane flanked domain; Region: DUF304; cl01348 227882011278 Bacterial membrane flanked domain; Region: DUF304; cl01348 227882011279 Bacterial membrane flanked domain; Region: DUF304; cl01348 227882011280 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 227882011281 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636 227882011282 Histidine kinase; Region: HisKA_3; pfam07730 227882011283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882011284 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882011285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882011286 active site 227882011287 phosphorylation site [posttranslational modification] 227882011288 intermolecular recognition site; other site 227882011289 dimerization interface [polypeptide binding]; other site 227882011290 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882011291 DNA binding residues [nucleotide binding] 227882011292 dimerization interface [polypeptide binding]; other site 227882011293 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 227882011294 dimerization interface [polypeptide binding]; other site 227882011295 putative DNA binding site [nucleotide binding]; other site 227882011296 putative Zn2+ binding site [ion binding]; other site 227882011297 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882011298 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 227882011299 catalytic residue [active] 227882011300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882011301 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 227882011302 Pantoate-beta-alanine ligase; Region: PanC; cd00560 227882011303 active site 227882011304 ATP-binding site [chemical binding]; other site 227882011305 pantoate-binding site; other site 227882011306 HXXH motif; other site 227882011307 L-aspartate oxidase; Provisional; Region: PRK07804 227882011308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882011309 domain; Region: Succ_DH_flav_C; pfam02910 227882011310 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 227882011311 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 227882011312 dimerization interface [polypeptide binding]; other site 227882011313 active site 227882011314 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 227882011315 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882011316 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 227882011317 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 227882011318 Coenzyme A binding pocket [chemical binding]; other site 227882011319 Lsr2; Region: Lsr2; pfam11774 227882011320 Clp protease ATP binding subunit; Region: clpC; CHL00095 227882011321 Clp amino terminal domain; Region: Clp_N; pfam02861 227882011322 Clp amino terminal domain; Region: Clp_N; pfam02861 227882011323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882011324 Walker A motif; other site 227882011325 ATP binding site [chemical binding]; other site 227882011326 Walker B motif; other site 227882011327 arginine finger; other site 227882011328 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882011329 Walker A motif; other site 227882011330 ATP binding site [chemical binding]; other site 227882011331 Walker B motif; other site 227882011332 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 227882011333 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 227882011334 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882011335 Peptidase family M23; Region: Peptidase_M23; pfam01551 227882011336 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882011337 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882011338 Major Facilitator Superfamily; Region: MFS_1; pfam07690 227882011339 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882011340 putative substrate translocation pore; other site 227882011341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882011342 putative substrate translocation pore; other site 227882011343 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882011344 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 227882011345 dimer interface [polypeptide binding]; other site 227882011346 phosphorylation site [posttranslational modification] 227882011347 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882011348 ATP binding site [chemical binding]; other site 227882011349 Mg2+ binding site [ion binding]; other site 227882011350 G-X-G motif; other site 227882011351 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 227882011352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882011353 active site 227882011354 phosphorylation site [posttranslational modification] 227882011355 intermolecular recognition site; other site 227882011356 dimerization interface [polypeptide binding]; other site 227882011357 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882011358 DNA binding site [nucleotide binding] 227882011359 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 227882011360 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882011361 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882011362 DNA binding residues [nucleotide binding] 227882011363 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 227882011364 endonuclease III; Region: ENDO3c; smart00478 227882011365 minor groove reading motif; other site 227882011366 helix-hairpin-helix signature motif; other site 227882011367 substrate binding pocket [chemical binding]; other site 227882011368 active site 227882011369 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 227882011370 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 227882011371 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 227882011372 DNA repair protein RadA; Provisional; Region: PRK11823 227882011373 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882011374 Walker A motif; other site 227882011375 ATP binding site [chemical binding]; other site 227882011376 Walker B motif; other site 227882011377 exopolyphosphatase; Region: exo_poly_only; TIGR03706 227882011378 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 227882011379 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 227882011380 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 227882011381 Metal-binding active site; metal-binding site 227882011382 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882011383 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882011384 Dehydratase family; Region: ILVD_EDD; cl00340 227882011385 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 227882011386 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882011387 Catalytic domain of Protein Kinases; Region: PKc; cd00180 227882011388 active site 227882011389 ATP binding site [chemical binding]; other site 227882011390 substrate binding site [chemical binding]; other site 227882011391 activation loop (A-loop); other site 227882011392 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 227882011393 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 227882011394 Dehydrogenases with pyrrolo-quinoline quinone (PQQ) as cofactor, like ethanol, methanol, and membrane bound glucose dehydrogenases. The alignment model contains an 8-bladed beta-propeller; Region: PQQ_DH; cl11493 227882011395 Bacterial SH3 domain; Region: SH3_3; cl02551 227882011396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882011397 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 227882011398 Sulfate transporter family; Region: Sulfate_transp; cl00967 227882011399 PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 227882011400 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 227882011401 Walker A/P-loop; other site 227882011402 ATP binding site [chemical binding]; other site 227882011403 Q-loop/lid; other site 227882011404 ABC transporter signature motif; other site 227882011405 Walker B; other site 227882011406 D-loop; other site 227882011407 H-loop/switch region; other site 227882011408 ABC-2 type transporter; Region: ABC2_membrane; cl11417 227882011409 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 227882011410 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882011411 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 227882011412 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 227882011413 active site 227882011414 HIGH motif; other site 227882011415 dimer interface [polypeptide binding]; other site 227882011416 KMSKS motif; other site 227882011417 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 227882011418 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 227882011419 active site 227882011420 motif I; other site 227882011421 motif II; other site 227882011422 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 227882011423 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 227882011424 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 227882011425 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 227882011426 putative NAD(P) binding site [chemical binding]; other site 227882011427 active site 227882011428 putative substrate binding site [chemical binding]; other site 227882011429 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 227882011430 putative acyl-acceptor binding pocket; other site 227882011431 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 227882011432 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882011433 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882011434 DNA binding residues [nucleotide binding] 227882011435 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 227882011436 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882011437 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 227882011438 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 227882011439 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 227882011440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882011441 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 227882011442 tRNA; other site 227882011443 putative tRNA binding site [nucleotide binding]; other site 227882011444 putative NADP binding site [chemical binding]; other site 227882011445 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 227882011446 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 227882011447 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 227882011448 domain interfaces; other site 227882011449 active site 227882011450 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 227882011451 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 227882011452 active site 227882011453 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 227882011454 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 227882011455 dimer interface [polypeptide binding]; other site 227882011456 active site 227882011457 Schiff base residues; other site 227882011458 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882011459 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 227882011460 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882011461 active site 227882011462 ATP binding site [chemical binding]; other site 227882011463 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 227882011464 arginine-tRNA ligase; Region: PLN02286 227882011465 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 227882011466 active site 227882011467 HIGH motif; other site 227882011468 KMSK motif region; other site 227882011469 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 227882011470 tRNA binding surface [nucleotide binding]; other site 227882011471 anticodon binding site; other site 227882011472 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 227882011473 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 227882011474 active site 227882011475 nucleotide binding site [chemical binding]; other site 227882011476 HIGH motif; other site 227882011477 KMSKS motif; other site 227882011478 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 227882011479 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 227882011480 hypothetical protein; Reviewed; Region: PRK09588 227882011481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882011482 NAD(P) binding site [chemical binding]; other site 227882011483 active site 227882011484 Uncharacterised BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 227882011485 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882011486 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882011487 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 227882011488 putative NAD(P) binding site [chemical binding]; other site 227882011489 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 227882011490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882011491 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 227882011492 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882011493 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 227882011494 CE1758 family; Region: LLM_CE1758_fam; TIGR04036 227882011495 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882011496 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882011497 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 227882011498 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 227882011499 putative ADP-binding pocket [chemical binding]; other site 227882011500 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 227882011501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882011502 active site 227882011503 phosphorylation site [posttranslational modification] 227882011504 intermolecular recognition site; other site 227882011505 dimerization interface [polypeptide binding]; other site 227882011506 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882011507 DNA binding site [nucleotide binding] 227882011508 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 227882011509 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882011510 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 227882011511 dimer interface [polypeptide binding]; other site 227882011512 phosphorylation site [posttranslational modification] 227882011513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882011514 ATP binding site [chemical binding]; other site 227882011515 G-X-G motif; other site 227882011516 Predicted transcriptional regulator [Transcription]; Region: COG2378 227882011517 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 227882011518 potential catalytic triad [active] 227882011519 conserved cys residue [active] 227882011520 Transcriptional regulator [Transcription]; Region: LysR; COG0583 227882011521 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882011522 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 227882011523 dimerization interface [polypeptide binding]; other site 227882011524 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 227882011525 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 227882011526 DNA-binding site [nucleotide binding]; DNA binding site 227882011527 RNA-binding motif; other site 227882011528 Domain of unknown function (DUF305); Region: DUF305; pfam03713 227882011529 Domain of unknown function (DUF305); Region: DUF305; pfam03713 227882011530 haloalkane dehalogenase; Provisional; Region: PRK03592 227882011531 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882011532 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 227882011533 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882011534 NAD(P) binding site [chemical binding]; other site 227882011535 active site 227882011536 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882011537 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882011538 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 227882011539 anti sigma factor interaction site; other site 227882011540 regulatory phosphorylation site [posttranslational modification]; other site 227882011541 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 227882011542 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 227882011543 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882011544 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 227882011545 putative dimerization interface [polypeptide binding]; other site 227882011546 EamA-like transporter family; Region: EamA; cl01037 227882011547 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 227882011548 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 227882011549 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 227882011550 NAD binding site [chemical binding]; other site 227882011551 substrate binding site [chemical binding]; other site 227882011552 putative active site [active] 227882011553 104 kDa microneme/rhoptry antigen; Provisional; Region: PTZ00449 227882011554 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 227882011555 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 227882011556 inhibitor-cofactor binding pocket; inhibition site 227882011557 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882011558 catalytic residue [active] 227882011559 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 227882011560 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 227882011561 catalytic core [active] 227882011562 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 227882011563 catalytic residues [active] 227882011564 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 227882011565 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 227882011566 ResB-like family; Region: ResB; pfam05140 227882011567 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 227882011568 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 227882011569 hydrophobic ligand binding site; other site 227882011570 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344 227882011571 Receptor family ligand binding region; Region: ANF_receptor; pfam01094 227882011572 putative ligand binding site [chemical binding]; other site 227882011573 flavanone-3-hydroxylase; Provisional; Region: PLN03176 227882011574 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 227882011575 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 227882011576 nucleoside/Zn binding site; other site 227882011577 dimer interface [polypeptide binding]; other site 227882011578 catalytic motif [active] 227882011579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882011580 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 227882011581 UbiA prenyltransferase family; Region: UbiA; cl00337 227882011582 aromatic acid decarboxylase; Validated; Region: PRK05920 227882011583 Flavoprotein; Region: Flavoprotein; cl08021 227882011584 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 227882011585 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882011586 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 227882011587 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 227882011588 FeS/SAM binding site; other site 227882011589 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 227882011590 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 227882011591 Coenzyme A binding pocket [chemical binding]; other site 227882011592 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882011593 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882011594 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 227882011595 active site 2 [active] 227882011596 active site 1 [active] 227882011597 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 227882011598 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882011599 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 227882011600 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 227882011601 DNA-binding site [nucleotide binding]; DNA binding site 227882011602 RNA-binding motif; other site 227882011603 Putative periplasminc binding protein (DUF178); Region: DUF178; cl15271 227882011604 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 227882011605 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882011606 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882011607 active site 227882011608 ATP binding site [chemical binding]; other site 227882011609 substrate binding site [chemical binding]; other site 227882011610 activation loop (A-loop); other site 227882011611 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 227882011612 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 227882011613 FeS/SAM binding site; other site 227882011614 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 227882011615 active site 227882011616 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 227882011617 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 227882011618 DXD motif; other site 227882011619 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 227882011620 Acyltransferase family; Region: Acyl_transf_3; pfam01757 227882011621 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 227882011622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882011623 S-adenosylmethionine binding site [chemical binding]; other site 227882011624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882011625 Double zinc ribbon; Region: DZR; pfam12773 227882011626 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 227882011627 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 227882011628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882011629 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 227882011630 geranylgeranyl diphosphate reductase; Provisional; Region: PLN00093 227882011631 NlpC/P60 family; Region: NLPC_P60; cl11438 227882011632 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 227882011633 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 227882011634 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 227882011635 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 227882011636 NADH-quinone oxidoreductase, E subunit; Region: nuoE_fam; TIGR01958 227882011637 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064 227882011638 putative dimer interface [polypeptide binding]; other site 227882011639 [2Fe-2S] cluster binding site [ion binding]; other site 227882011640 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 227882011641 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 227882011642 SLBB domain; Region: SLBB; pfam10531 227882011643 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 227882011644 NADH dehydrogenase subunit G; Validated; Region: PRK07860 227882011645 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 227882011646 catalytic loop [active] 227882011647 iron binding site [ion binding]; other site 227882011648 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 227882011649 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 227882011650 molybdopterin cofactor binding site; other site 227882011651 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 227882011652 NADH dehydrogenase; Region: NADHdh; cl00469 227882011653 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 227882011654 4Fe-4S binding domain; Region: Fer4; cl02805 227882011655 4Fe-4S binding domain; Region: Fer4; cl02805 227882011656 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 227882011657 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 227882011658 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 227882011659 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 227882011660 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 227882011661 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 227882011662 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 227882011663 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 227882011664 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 227882011665 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 227882011666 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 227882011667 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 227882011668 ATP binding site [chemical binding]; other site 227882011669 putative Mg++ binding site [ion binding]; other site 227882011670 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 227882011671 nucleotide binding region [chemical binding]; other site 227882011672 ATP-binding site [chemical binding]; other site 227882011673 RQC domain; Region: RQC; cl09632 227882011674 HRDC domain; Region: HRDC; cl02578 227882011675 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 227882011676 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882011677 domain; Region: Succ_DH_flav_C; pfam02910 227882011678 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 227882011679 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 227882011680 Walker A/P-loop; other site 227882011681 ATP binding site [chemical binding]; other site 227882011682 Q-loop/lid; other site 227882011683 ABC transporter signature motif; other site 227882011684 Walker B; other site 227882011685 D-loop; other site 227882011686 H-loop/switch region; other site 227882011687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882011688 dimer interface [polypeptide binding]; other site 227882011689 conserved gate region; other site 227882011690 putative PBP binding loops; other site 227882011691 ABC-ATPase subunit interface; other site 227882011692 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 227882011693 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 227882011694 archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700 227882011695 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882011696 DNA-binding site [nucleotide binding]; DNA binding site 227882011697 UTRA domain; Region: UTRA; cl01230 227882011698 fumarylacetoacetase; Region: PLN02856 227882011699 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 227882011700 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 227882011701 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 227882011702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882011703 putative bacillithiol system thiol disulfide oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 227882011704 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 227882011705 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 227882011706 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 227882011707 Predicted acyl esterases [General function prediction only]; Region: COG2936 227882011708 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882011709 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 227882011710 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 227882011711 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 227882011712 substrate binding pocket [chemical binding]; other site 227882011713 chain length determination region; other site 227882011714 substrate-Mg2+ binding site; other site 227882011715 catalytic residues [active] 227882011716 aspartate-rich region 1; other site 227882011717 active site lid residues [active] 227882011718 aspartate-rich region 2; other site 227882011719 CHRD domain; Region: CHRD; cl06473 227882011720 Protein of unknown function (DUF3455); Region: DUF3455; pfam11937 227882011721 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 227882011722 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 227882011723 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882011724 Walker A/P-loop; other site 227882011725 ATP binding site [chemical binding]; other site 227882011726 Q-loop/lid; other site 227882011727 ABC transporter signature motif; other site 227882011728 Walker B; other site 227882011729 D-loop; other site 227882011730 H-loop/switch region; other site 227882011731 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 227882011732 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 227882011733 active site 227882011734 metal binding site [ion binding]; metal-binding site 227882011735 Predicted permeases [General function prediction only]; Region: RarD; COG2962 227882011736 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 227882011737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882011738 NAD(P) binding site [chemical binding]; other site 227882011739 active site 227882011740 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882011741 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 227882011742 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 227882011743 TPP-binding site [chemical binding]; other site 227882011744 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 227882011745 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 227882011746 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 227882011747 dimer interface [polypeptide binding]; other site 227882011748 PYR/PP interface [polypeptide binding]; other site 227882011749 TPP binding site [chemical binding]; other site 227882011750 substrate binding site [chemical binding]; other site 227882011751 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882011752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882011753 active site 227882011754 phosphorylation site [posttranslational modification] 227882011755 intermolecular recognition site; other site 227882011756 dimerization interface [polypeptide binding]; other site 227882011757 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882011758 DNA binding residues [nucleotide binding] 227882011759 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 227882011760 Histidine kinase; Region: HisKA_3; pfam07730 227882011761 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 227882011762 Histidine kinase; Region: HisKA_3; pfam07730 227882011763 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 227882011764 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 227882011765 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 227882011766 NADH dehydrogenase; Region: NADHdh; cl00469 227882011767 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 227882011768 4Fe-4S binding domain; Region: Fer4; cl02805 227882011769 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 227882011770 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 227882011771 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 227882011772 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 227882011773 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 227882011774 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 227882011775 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 227882011776 Peptidase family M48; Region: Peptidase_M48; cl12018 227882011777 hypothetical protein; Provisional; Region: PRK11770 227882011778 Domain of unknown function (DUF307); Region: DUF307; pfam03733 227882011779 Domain of unknown function (DUF307); Region: DUF307; pfam03733 227882011780 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 227882011781 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882011782 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 227882011783 Protein of unknown function (DUF520); Region: DUF520; cl00723 227882011784 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 227882011785 amidohydrolase; Region: amidohydrolases; TIGR01891 227882011786 metal binding site [ion binding]; metal-binding site 227882011787 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 227882011788 NAD(P) binding site [chemical binding]; other site 227882011789 putative active site [active] 227882011790 cytosine deaminase; Provisional; Region: PRK05985 227882011791 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and...; Region: Bact_CD; cd01293 227882011792 active site 227882011793 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 227882011794 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 227882011795 active site 227882011796 catalytic site [active] 227882011797 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 227882011798 active site 227882011799 catalytic site [active] 227882011800 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882011801 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 227882011802 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882011803 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 227882011804 FAD binding domain; Region: FAD_binding_4; pfam01565 227882011805 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 227882011806 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 227882011807 active site 227882011808 hypothetical protein; Validated; Region: PRK07682 227882011809 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 227882011810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882011811 homodimer interface [polypeptide binding]; other site 227882011812 catalytic residue [active] 227882011813 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 227882011814 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 227882011815 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 227882011816 putative homodimer interface [polypeptide binding]; other site 227882011817 KOW motif; Region: KOW; cl00354 227882011818 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 227882011819 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 227882011820 23S rRNA interface [nucleotide binding]; other site 227882011821 L7/L12 interface [polypeptide binding]; other site 227882011822 putative thiostrepton binding site; other site 227882011823 L25 interface [polypeptide binding]; other site 227882011824 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 227882011825 mRNA/rRNA interface [nucleotide binding]; other site 227882011826 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 227882011827 23S rRNA interface [nucleotide binding]; other site 227882011828 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 227882011829 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 227882011830 core dimer interface [polypeptide binding]; other site 227882011831 L10 interface [polypeptide binding]; other site 227882011832 L11 interface [polypeptide binding]; other site 227882011833 putative EF-Tu interaction site [polypeptide binding]; other site 227882011834 putative EF-G interaction site [polypeptide binding]; other site 227882011835 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 227882011836 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 227882011837 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 227882011838 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 227882011839 RPB1 interaction site [polypeptide binding]; other site 227882011840 RPB10 interaction site [polypeptide binding]; other site 227882011841 RPB11 interaction site [polypeptide binding]; other site 227882011842 RPB3 interaction site [polypeptide binding]; other site 227882011843 RPB12 interaction site [polypeptide binding]; other site 227882011844 RNA polymerase beta' subunit; Region: rpoC1; CHL00018 227882011845 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 227882011846 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 227882011847 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 227882011848 RNA polymerase beta'' subunit; Reviewed; Region: rpoC2; CHL00117 227882011849 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 227882011850 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 227882011851 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 227882011852 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 227882011853 G-loop; other site 227882011854 DNA binding site [nucleotide binding] 227882011855 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 227882011856 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 227882011857 S17 interaction site [polypeptide binding]; other site 227882011858 S8 interaction site; other site 227882011859 16S rRNA interaction site [nucleotide binding]; other site 227882011860 streptomycin interaction site [chemical binding]; other site 227882011861 23S rRNA interaction site [nucleotide binding]; other site 227882011862 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 227882011863 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 227882011864 elongation factor G; Reviewed; Region: PRK00007 227882011865 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 227882011866 G1 box; other site 227882011867 putative GEF interaction site [polypeptide binding]; other site 227882011868 GTP/Mg2+ binding site [chemical binding]; other site 227882011869 Switch I region; other site 227882011870 G2 box; other site 227882011871 G3 box; other site 227882011872 Switch II region; other site 227882011873 G4 box; other site 227882011874 G5 box; other site 227882011875 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 227882011876 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 227882011877 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 227882011878 elongation factor Tu; Reviewed; Region: PRK00049 227882011879 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 227882011880 G1 box; other site 227882011881 GEF interaction site [polypeptide binding]; other site 227882011882 GTP/Mg2+ binding site [chemical binding]; other site 227882011883 Switch I region; other site 227882011884 G2 box; other site 227882011885 G3 box; other site 227882011886 Switch II region; other site 227882011887 G4 box; other site 227882011888 G5 box; other site 227882011889 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding...; Region: Translation_Factor_II_like; cl02787 227882011890 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 227882011891 Antibiotic Binding Site [chemical binding]; other site 227882011892 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 227882011893 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882011894 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882011895 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 227882011896 putative dimerization interface [polypeptide binding]; other site 227882011897 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 227882011898 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 227882011899 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 227882011900 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 227882011901 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 227882011902 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 227882011903 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 227882011904 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 227882011905 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 227882011906 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 227882011907 putative translocon binding site; other site 227882011908 protein-rRNA interface [nucleotide binding]; other site 227882011909 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 227882011910 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 227882011911 G-X-X-G motif; other site 227882011912 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 227882011913 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 227882011914 23S rRNA interface [nucleotide binding]; other site 227882011915 5S rRNA interface [nucleotide binding]; other site 227882011916 putative antibiotic binding site [chemical binding]; other site 227882011917 L25 interface [polypeptide binding]; other site 227882011918 L27 interface [polypeptide binding]; other site 227882011919 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 227882011920 23S rRNA interface [nucleotide binding]; other site 227882011921 putative translocon interaction site; other site 227882011922 signal recognition particle (SRP54) interaction site; other site 227882011923 L23 interface [polypeptide binding]; other site 227882011924 trigger factor interaction site; other site 227882011925 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 227882011926 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 227882011927 KOW motif; Region: KOW; cl00354 227882011928 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 227882011929 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 227882011930 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 227882011931 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 227882011932 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 227882011933 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 227882011934 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 227882011935 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 227882011936 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 227882011937 5S rRNA interface [nucleotide binding]; other site 227882011938 L27 interface [polypeptide binding]; other site 227882011939 L5 interface [polypeptide binding]; other site 227882011940 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 227882011941 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 227882011942 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 227882011943 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 227882011944 23S rRNA binding site [nucleotide binding]; other site 227882011945 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 227882011946 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 227882011947 SecY translocase; Region: SecY; pfam00344 227882011948 adenylate kinase; Reviewed; Region: adk; PRK00279 227882011949 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 227882011950 AMP-binding site [chemical binding]; other site 227882011951 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 227882011952 methionine aminopeptidase; Reviewed; Region: PRK07281 227882011953 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 227882011954 active site 227882011955 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 227882011956 rRNA binding site [nucleotide binding]; other site 227882011957 predicted 30S ribosome binding site; other site 227882011958 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 227882011959 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 227882011960 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 227882011961 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 227882011962 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 227882011963 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 227882011964 alphaNTD homodimer interface [polypeptide binding]; other site 227882011965 alphaNTD - beta interaction site [polypeptide binding]; other site 227882011966 alphaNTD - beta' interaction site [polypeptide binding]; other site 227882011967 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 227882011968 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 227882011969 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 227882011970 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 227882011971 dimerization interface 3.5A [polypeptide binding]; other site 227882011972 active site 227882011973 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 227882011974 23S rRNA interface [nucleotide binding]; other site 227882011975 L3 interface [polypeptide binding]; other site 227882011976 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 227882011977 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 227882011978 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 227882011979 active site 227882011980 substrate binding site [chemical binding]; other site 227882011981 metal binding site [ion binding]; metal-binding site 227882011982 Domain of unknown function (DUF389); Region: DUF389; cl00781 227882011983 pantothenate kinase; Provisional; Region: PRK05439 227882011984 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 227882011985 ATP-binding site [chemical binding]; other site 227882011986 CoA-binding site [chemical binding]; other site 227882011987 Mg2+-binding site [ion binding]; other site 227882011988 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 227882011989 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 227882011990 glutaminase active site [active] 227882011991 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 227882011992 dimer interface [polypeptide binding]; other site 227882011993 active site 227882011994 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 227882011995 dimer interface [polypeptide binding]; other site 227882011996 active site 227882011997 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 227882011998 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 227882011999 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 227882012000 putative substrate binding site [chemical binding]; other site 227882012001 putative ATP binding site [chemical binding]; other site 227882012002 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 227882012003 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 227882012004 alanine racemase; Reviewed; Region: alr; PRK00053 227882012005 active site 227882012006 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 227882012007 dimer interface [polypeptide binding]; other site 227882012008 substrate binding site [chemical binding]; other site 227882012009 catalytic residues [active] 227882012010 Chlorophyllase; Region: Chlorophyllase; cl15281 227882012011 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882012012 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882012013 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 227882012014 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 227882012015 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 227882012016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882012017 putative glycoprotease GCP; Region: bact_gcp; TIGR03723 227882012018 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 227882012019 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882012020 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882012021 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882012022 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882012023 DNA binding site [nucleotide binding] 227882012024 domain linker motif; other site 227882012025 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 227882012026 putative dimerization interface [polypeptide binding]; other site 227882012027 putative ligand binding site [chemical binding]; other site 227882012028 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882012029 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 227882012030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882012031 dimer interface [polypeptide binding]; other site 227882012032 conserved gate region; other site 227882012033 putative PBP binding loops; other site 227882012034 ABC-ATPase subunit interface; other site 227882012035 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 227882012036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882012037 dimer interface [polypeptide binding]; other site 227882012038 conserved gate region; other site 227882012039 putative PBP binding loops; other site 227882012040 ABC-ATPase subunit interface; other site 227882012041 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 227882012042 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 227882012043 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 227882012044 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 227882012045 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882012046 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882012047 DNA binding site [nucleotide binding] 227882012048 domain linker motif; other site 227882012049 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 227882012050 putative dimerization interface [polypeptide binding]; other site 227882012051 putative ligand binding site [chemical binding]; other site 227882012052 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 227882012053 Cellulose binding domain; Region: CBM_2; cl02709 227882012054 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 227882012055 YCII-related domain; Region: YCII; cl00999 227882012056 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 227882012057 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882012058 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882012059 S-adenosylmethionine binding site [chemical binding]; other site 227882012060 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 227882012061 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 227882012062 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 227882012063 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 227882012064 oligomerisation interface [polypeptide binding]; other site 227882012065 mobile loop; other site 227882012066 roof hairpin; other site 227882012067 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 227882012068 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 227882012069 ring oligomerisation interface [polypeptide binding]; other site 227882012070 ATP/Mg binding site [chemical binding]; other site 227882012071 stacking interactions; other site 227882012072 hinge regions; other site 227882012073 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 227882012074 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 227882012075 classical (c) SDRs; Region: SDR_c; cd05233 227882012076 NAD(P) binding site [chemical binding]; other site 227882012077 active site 227882012078 MOSC domain; Region: MOSC; pfam03473 227882012079 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882012080 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 227882012081 putative dimerization interface [polypeptide binding]; other site 227882012082 Transcription factor WhiB; Region: Whib; pfam02467 227882012083 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882012084 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882012085 active site 227882012086 phosphorylation site [posttranslational modification] 227882012087 intermolecular recognition site; other site 227882012088 dimerization interface [polypeptide binding]; other site 227882012089 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882012090 DNA binding residues [nucleotide binding] 227882012091 dimerization interface [polypeptide binding]; other site 227882012092 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 227882012093 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882012094 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882012095 DNA binding residues [nucleotide binding] 227882012096 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 227882012097 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 227882012098 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 227882012099 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 227882012100 active site 227882012101 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 227882012102 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 227882012103 active site 227882012104 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 227882012105 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 227882012106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882012107 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 227882012108 Beta-lactamase; Region: Beta-lactamase; cl01009 227882012109 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882012110 Catalytic domain of Protein Kinases; Region: PKc; cd00180 227882012111 active site 227882012112 ATP binding site [chemical binding]; other site 227882012113 substrate binding site [chemical binding]; other site 227882012114 activation loop (A-loop); other site 227882012115 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882012116 ATP binding site [chemical binding]; other site 227882012117 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882012118 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882012119 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882012120 active site 227882012121 ATP binding site [chemical binding]; other site 227882012122 substrate binding site [chemical binding]; other site 227882012123 activation loop (A-loop); other site 227882012124 Catalytic domain of Protein Kinases; Region: PKc; cd00180 227882012125 active site 227882012126 ATP binding site [chemical binding]; other site 227882012127 substrate binding site [chemical binding]; other site 227882012128 activation loop (A-loop); other site 227882012129 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882012130 Catalytic domain of Protein Kinases; Region: PKc; cd00180 227882012131 active site 227882012132 ATP binding site [chemical binding]; other site 227882012133 substrate binding site [chemical binding]; other site 227882012134 activation loop (A-loop); other site 227882012135 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882012136 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882012137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882012138 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 227882012139 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 227882012140 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 227882012141 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 227882012142 NAD(P) binding site [chemical binding]; other site 227882012143 catalytic residues [active] 227882012144 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 227882012145 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 227882012146 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 227882012147 Chorismate mutase type II; Region: CM_2; cl00693 227882012148 GtrA-like protein; Region: GtrA; cl00971 227882012149 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 227882012150 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 227882012151 AIR carboxylase; Region: AIRC; cl00310 227882012152 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics...; Region: rDP_like; cd01301 227882012153 active site 227882012154 dimer interface [polypeptide binding]; other site 227882012155 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 227882012156 active site 227882012157 metal binding site [ion binding]; metal-binding site 227882012158 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 227882012159 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 227882012160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882012161 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 227882012162 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 227882012163 FAD binding site [chemical binding]; other site 227882012164 homotetramer interface [polypeptide binding]; other site 227882012165 substrate binding pocket [chemical binding]; other site 227882012166 catalytic base [active] 227882012167 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 227882012168 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882012169 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 227882012170 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain...; Region: BFIT_BACH; cd03442 227882012171 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 227882012172 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 227882012173 Ligand binding site [chemical binding]; other site 227882012174 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 227882012175 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 227882012176 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 227882012177 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882012178 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 227882012179 amidase catalytic site [active] 227882012180 Zn binding residues [ion binding]; other site 227882012181 substrate binding site [chemical binding]; other site 227882012182 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 227882012183 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 227882012184 active site 227882012185 Substrate binding site [chemical binding]; other site 227882012186 Mg++ binding site [ion binding]; other site 227882012187 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 227882012188 putative trimer interface [polypeptide binding]; other site 227882012189 putative CoA binding site [chemical binding]; other site 227882012190 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 227882012191 minor groove reading motif; other site 227882012192 helix-hairpin-helix signature motif; other site 227882012193 active site 227882012194 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 227882012195 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 227882012196 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes...; Region: NADPH_oxidoreductase_1; cd02150 227882012197 putative FMN binding site [chemical binding]; other site 227882012198 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 227882012199 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 227882012200 phosphate binding site [ion binding]; other site 227882012201 dimer interface [polypeptide binding]; other site 227882012202 substrate binding site [chemical binding]; other site 227882012203 Cysteine dioxygenase type I; Region: CDO_I; cl02350 227882012204 Transcription factor WhiB; Region: Whib; pfam02467 227882012205 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 227882012206 active site 227882012207 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 227882012208 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 227882012209 L-lactate permease; Region: Lactate_perm; cl00701 227882012210 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 227882012211 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 227882012212 active site 227882012213 substrate binding site [chemical binding]; other site 227882012214 metal binding site [ion binding]; metal-binding site 227882012215 Trm112p-like protein; Region: Trm112p; cl01066 227882012216 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 227882012217 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 227882012218 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 227882012219 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 227882012220 Cation efflux family; Region: Cation_efflux; cl00316 227882012221 Adenosylhomocysteinase; Provisional; Region: PTZ00075 227882012222 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado...; Region: AdoHcyase; cd00401 227882012223 oligomerization interface [polypeptide binding]; other site 227882012224 active site 227882012225 NAD+ binding site [chemical binding]; other site 227882012226 RDD family; Region: RDD; cl00746 227882012227 Integral membrane protein DUF95; Region: DUF95; cl00572 227882012228 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 227882012229 Domain of unknown function DUF11; Region: DUF11; cl15273 227882012230 Protein of unknown function DUF58; Region: DUF58; pfam01882 227882012231 MoxR-like ATPases [General function prediction only]; Region: COG0714 227882012232 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882012233 Walker A motif; other site 227882012234 ATP binding site [chemical binding]; other site 227882012235 Walker B motif; other site 227882012236 arginine finger; other site 227882012237 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 227882012238 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 227882012239 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 227882012240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882012241 active site 227882012242 phosphorylation site [posttranslational modification] 227882012243 intermolecular recognition site; other site 227882012244 dimerization interface [polypeptide binding]; other site 227882012245 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882012246 DNA binding site [nucleotide binding] 227882012247 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 227882012248 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882012249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 227882012250 dimer interface [polypeptide binding]; other site 227882012251 phosphorylation site [posttranslational modification] 227882012252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882012253 lipoprotein LpqB; Provisional; Region: PRK13613 227882012254 Sporulation and spore germination; Region: Germane; cl11253 227882012255 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 227882012256 30S subunit binding site; other site 227882012257 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882012258 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882012259 active site 227882012260 phosphorylation site [posttranslational modification] 227882012261 intermolecular recognition site; other site 227882012262 dimerization interface [polypeptide binding]; other site 227882012263 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882012264 DNA binding residues [nucleotide binding] 227882012265 dimerization interface [polypeptide binding]; other site 227882012266 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 227882012267 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 227882012268 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882012269 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 227882012270 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882012271 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 227882012272 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 227882012273 nucleotide binding region [chemical binding]; other site 227882012274 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882012275 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 227882012276 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 227882012277 GtrA-like protein; Region: GtrA; cl00971 227882012278 putative glycosyl transferase; Provisional; Region: PRK10073 227882012279 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 227882012280 active site 227882012281 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 227882012282 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 227882012283 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 227882012284 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides...; Region: ABC_KpsT_Wzt; cd03220 227882012285 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 227882012286 Walker A/P-loop; other site 227882012287 ATP binding site [chemical binding]; other site 227882012288 Q-loop/lid; other site 227882012289 ABC transporter signature motif; other site 227882012290 Walker B; other site 227882012291 D-loop; other site 227882012292 H-loop/switch region; other site 227882012293 ABC-2 type transporter; Region: ABC2_membrane; cl11417 227882012294 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882012295 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 227882012296 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882012297 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882012298 short chain dehydrogenase; Provisional; Region: PRK06197 227882012299 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 227882012300 putative NAD(P) binding site [chemical binding]; other site 227882012301 active site 227882012302 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 227882012303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882012304 NAD(P) binding site [chemical binding]; other site 227882012305 active site 227882012306 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 227882012307 active site 227882012308 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 227882012309 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882012310 OsmC-like protein; Region: OsmC; cl00767 227882012311 putative glycosyl transferase; Provisional; Region: PRK10073 227882012312 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 227882012313 active site 227882012314 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 227882012315 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 227882012316 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 227882012317 active site 227882012318 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 227882012319 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 227882012320 putative glycosyl transferase; Provisional; Region: PRK10073 227882012321 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 227882012322 active site 227882012323 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 227882012324 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 227882012325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882012326 dimer interface [polypeptide binding]; other site 227882012327 conserved gate region; other site 227882012328 putative PBP binding loops; other site 227882012329 ABC-ATPase subunit interface; other site 227882012330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 227882012331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882012332 ABC-ATPase subunit interface; other site 227882012333 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 227882012334 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882012335 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 227882012336 phosphopeptide binding site; other site 227882012337 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 227882012338 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 227882012339 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882012340 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882012341 active site 227882012342 ATP binding site [chemical binding]; other site 227882012343 substrate binding site [chemical binding]; other site 227882012344 activation loop (A-loop); other site 227882012345 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882012346 Catalytic domain of Protein Kinases; Region: PKc; cd00180 227882012347 active site 227882012348 ATP binding site [chemical binding]; other site 227882012349 substrate binding site [chemical binding]; other site 227882012350 activation loop (A-loop); other site 227882012351 peptide chain release factor 2; Validated; Region: prfB; PRK00578 227882012352 RF-1 domain; Region: RF-1; cl02875 227882012353 RF-1 domain; Region: RF-1; cl02875 227882012354 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 227882012355 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882012356 Walker A/P-loop; other site 227882012357 ATP binding site [chemical binding]; other site 227882012358 Q-loop/lid; other site 227882012359 ABC transporter signature motif; other site 227882012360 Walker B; other site 227882012361 D-loop; other site 227882012362 H-loop/switch region; other site 227882012363 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 227882012364 FtsX-like permease family; Region: FtsX; pfam02687 227882012365 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 227882012366 protein binding site [polypeptide binding]; other site 227882012367 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 227882012368 Catalytic dyad [active] 227882012369 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 227882012370 SmpB-tmRNA interface; other site 227882012371 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 227882012372 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such...; Region: APH_ChoK_like_1; cd05155 227882012373 putative active site [active] 227882012374 putative substrate binding site [chemical binding]; other site 227882012375 ATP binding site [chemical binding]; other site 227882012376 Cytochrome P450; Region: p450; cl12078 227882012377 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882012378 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882012379 dimerization interface [polypeptide binding]; other site 227882012380 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 227882012381 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 227882012382 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 227882012383 DXD motif; other site 227882012384 Acyltransferase family; Region: Acyl_transf_3; pfam01757 227882012385 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 227882012386 putative hydrophobic ligand binding site [chemical binding]; other site 227882012387 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 227882012388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882012389 putative substrate translocation pore; other site 227882012390 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 227882012391 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 227882012392 active site 227882012393 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882012394 DNA binding site [nucleotide binding] 227882012395 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 227882012396 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 227882012397 CGNR zinc finger; Region: zf-CGNR; pfam11706 227882012398 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 227882012399 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882012400 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882012401 DNA binding residues [nucleotide binding] 227882012402 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 227882012403 UvrD/REP helicase; Region: UvrD-helicase; cl14126 227882012404 UvrD/REP helicase; Region: UvrD-helicase; cl14126 227882012405 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 227882012406 Malic enzyme, N-terminal domain; Region: malic; pfam00390 227882012407 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 227882012408 putative NAD(P) binding site [chemical binding]; other site 227882012409 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 227882012410 IHF dimer interface [polypeptide binding]; other site 227882012411 IHF - DNA interface [nucleotide binding]; other site 227882012412 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 227882012413 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 227882012414 hinge; other site 227882012415 active site 227882012416 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 227882012417 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 227882012418 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 227882012419 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882012420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 227882012421 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 227882012422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882012423 dimer interface [polypeptide binding]; other site 227882012424 conserved gate region; other site 227882012425 putative PBP binding loops; other site 227882012426 ABC-ATPase subunit interface; other site 227882012427 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i); Region: GH20_chitobiase-like; cd06563 227882012428 active site 227882012429 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 227882012430 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 227882012431 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 227882012432 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 227882012433 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 227882012434 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 227882012435 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 227882012436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882012437 putative substrate translocation pore; other site 227882012438 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 227882012439 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 227882012440 ATP binding site [chemical binding]; other site 227882012441 putative Mg++ binding site [ion binding]; other site 227882012442 Transcriptional regulator [Transcription]; Region: IclR; COG1414 227882012443 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882012444 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 227882012445 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 227882012446 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 227882012447 dimerization interface [polypeptide binding]; other site 227882012448 putative DNA binding site [nucleotide binding]; other site 227882012449 putative Zn2+ binding site [ion binding]; other site 227882012450 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 227882012451 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 227882012452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882012453 dimer interface [polypeptide binding]; other site 227882012454 conserved gate region; other site 227882012455 ABC-ATPase subunit interface; other site 227882012456 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 227882012457 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 227882012458 Walker A/P-loop; other site 227882012459 ATP binding site [chemical binding]; other site 227882012460 Q-loop/lid; other site 227882012461 ABC transporter signature motif; other site 227882012462 Walker B; other site 227882012463 D-loop; other site 227882012464 H-loop/switch region; other site 227882012465 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 227882012466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 227882012467 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 227882012468 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882012469 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 227882012470 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 227882012471 dimer interface [polypeptide binding]; other site 227882012472 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 227882012473 active site 227882012474 Fe binding site [ion binding]; other site 227882012475 FAD binding domain; Region: FAD_binding_4; pfam01565 227882012476 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 227882012477 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 227882012478 RDD family; Region: RDD; cl00746 227882012479 RDD family; Region: RDD; cl00746 227882012480 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 227882012481 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 227882012482 Isochorismatase family; Region: Isochorismatase; pfam00857 227882012483 catalytic triad [active] 227882012484 metal binding site [ion binding]; metal-binding site 227882012485 conserved cis-peptide bond; other site 227882012486 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 227882012487 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 227882012488 active site 227882012489 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 227882012490 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 227882012491 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882012492 Amino acid permease; Region: AA_permease; pfam00324 227882012493 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 227882012494 MPN+ (JAMM) motif; other site 227882012495 Zinc-binding site [ion binding]; other site 227882012496 Ubiquitin-like proteins; Region: UBQ; cl00155 227882012497 charged pocket; other site 227882012498 hydrophobic patch; other site 227882012499 cysteine synthases; Region: cysKM; TIGR01136 227882012500 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 227882012501 dimer interface [polypeptide binding]; other site 227882012502 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882012503 catalytic residue [active] 227882012504 PemK-like protein; Region: PemK; cl00995 227882012505 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 227882012506 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 227882012507 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 227882012508 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 227882012509 active site turn [active] 227882012510 phosphorylation site [posttranslational modification] 227882012511 ribonuclease PH; Reviewed; Region: rph; PRK00173 227882012512 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 227882012513 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 227882012514 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 227882012515 active site 227882012516 dimerization interface [polypeptide binding]; other site 227882012517 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 227882012518 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882012519 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882012520 proline/glycine betaine transporter; Provisional; Region: PRK10642 227882012521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882012522 putative substrate translocation pore; other site 227882012523 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 227882012524 catalytic triad [active] 227882012525 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 227882012526 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 227882012527 oligomerisation interface [polypeptide binding]; other site 227882012528 mobile loop; other site 227882012529 roof hairpin; other site 227882012530 Transglycosylase; Region: Transgly; cl07896 227882012531 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 227882012532 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 227882012533 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 227882012534 Protein of unknown function (DUF990); Region: DUF990; cl01496 227882012535 Protein of unknown function (DUF990); Region: DUF990; cl01496 227882012536 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882012537 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 227882012538 Walker A/P-loop; other site 227882012539 ATP binding site [chemical binding]; other site 227882012540 Q-loop/lid; other site 227882012541 ABC transporter signature motif; other site 227882012542 Walker B; other site 227882012543 D-loop; other site 227882012544 H-loop/switch region; other site 227882012545 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 227882012546 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and...; Region: XynE_like; cd01830 227882012547 active site 227882012548 catalytic triad [active] 227882012549 oxyanion hole [active] 227882012550 Protein of unknown function (DUF445); Region: DUF445; pfam04286 227882012551 benzoate transport; Region: 2A0115; TIGR00895 227882012552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882012553 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882012554 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 227882012555 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 227882012556 conserved cys residue [active] 227882012557 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882012558 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882012559 Peptidase inhibitor family I36; Region: Inhibitor_I36; pfam03995 227882012560 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 227882012561 non-specific DNA binding site [nucleotide binding]; other site 227882012562 salt bridge; other site 227882012563 sequence-specific DNA binding site [nucleotide binding]; other site 227882012564 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 227882012565 non-specific DNA binding site [nucleotide binding]; other site 227882012566 salt bridge; other site 227882012567 sequence-specific DNA binding site [nucleotide binding]; other site 227882012568 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 227882012569 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882012570 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882012571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882012572 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b1; cd09203 227882012573 putative homodimer interface [polypeptide binding]; other site 227882012574 putative active site [active] 227882012575 catalytic site [active] 227882012576 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 227882012577 ATP binding site [chemical binding]; other site 227882012578 putative Mg++ binding site [ion binding]; other site 227882012579 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 227882012580 nucleotide binding region [chemical binding]; other site 227882012581 ATP-binding site [chemical binding]; other site 227882012582 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 227882012583 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 227882012584 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase_D_5; cd05830 227882012585 active site 227882012586 catalytic site [active] 227882012587 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 227882012588 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 227882012589 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 227882012590 Domain of unknown function (DUF336); Region: DUF336; cl01249 227882012591 putative oxidoreductase; Provisional; Region: PRK11579 227882012592 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882012593 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 227882012594 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882012595 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882012596 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 227882012597 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 227882012598 active site 227882012599 motif I; other site 227882012600 motif II; other site 227882012601 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 227882012602 active site 227882012603 motif I; other site 227882012604 motif II; other site 227882012605 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan...; Region: Sortase_E; cd05829 227882012606 active site 227882012607 putative catalytic site [active] 227882012608 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 227882012609 Kelch motif; Region: Kelch_1; cl02701 227882012610 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 227882012611 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 227882012612 DXD motif; other site 227882012613 cellulose synthase A; Region: PLN02195 227882012614 Transcriptional regulators [Transcription]; Region: FadR; COG2186 227882012615 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882012616 DNA-binding site [nucleotide binding]; DNA binding site 227882012617 FCD domain; Region: FCD; cl11656 227882012618 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 227882012619 Chitin binding domain; Region: Chitin_bind_3; cl03871 227882012620 acyl-CoA synthetase; Validated; Region: PRK07867 227882012621 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882012622 Transcriptional regulator [Transcription]; Region: IclR; COG1414 227882012623 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882012624 Bacterial transcriptional regulator; Region: IclR; pfam01614 227882012625 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 227882012626 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 227882012627 Walker A/P-loop; other site 227882012628 ATP binding site [chemical binding]; other site 227882012629 Q-loop/lid; other site 227882012630 ABC transporter signature motif; other site 227882012631 Walker B; other site 227882012632 D-loop; other site 227882012633 H-loop/switch region; other site 227882012634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882012635 dimer interface [polypeptide binding]; other site 227882012636 conserved gate region; other site 227882012637 putative PBP binding loops; other site 227882012638 ABC-ATPase subunit interface; other site 227882012639 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 227882012640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882012641 dimer interface [polypeptide binding]; other site 227882012642 conserved gate region; other site 227882012643 putative PBP binding loops; other site 227882012644 ABC-ATPase subunit interface; other site 227882012645 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 227882012646 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 227882012647 substrate binding pocket [chemical binding]; other site 227882012648 membrane-bound complex binding site; other site 227882012649 hinge residues; other site 227882012650 Protein of unknown function (DUF3830); Region: DUF3830; pfam12903 227882012651 putative amidase; Provisional; Region: PRK06169 227882012652 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 227882012653 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 227882012654 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882012655 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 227882012656 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 227882012657 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 227882012658 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882012659 PAS fold; Region: PAS_4; pfam08448 227882012660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 227882012661 putative active site [active] 227882012662 heme pocket [chemical binding]; other site 227882012663 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 227882012664 metal binding site [ion binding]; metal-binding site 227882012665 active site 227882012666 I-site; other site 227882012667 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 227882012668 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 227882012669 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882012670 ATP binding site [chemical binding]; other site 227882012671 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 227882012672 putative Mg++ binding site [ion binding]; other site 227882012673 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 227882012674 active site 227882012675 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 227882012676 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 227882012677 catalytic core [active] 227882012678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882012679 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 227882012680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882012681 active site 227882012682 phosphorylation site [posttranslational modification] 227882012683 intermolecular recognition site; other site 227882012684 dimerization interface [polypeptide binding]; other site 227882012685 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882012686 DNA binding site [nucleotide binding] 227882012687 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882012688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 227882012689 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882012690 ATP binding site [chemical binding]; other site 227882012691 Mg2+ binding site [ion binding]; other site 227882012692 G-X-G motif; other site 227882012693 Cellulose binding domain; Region: CBM_2; cl02709 227882012694 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 227882012695 active site 227882012696 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 227882012697 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 227882012698 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 227882012699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882012700 dimer interface [polypeptide binding]; other site 227882012701 conserved gate region; other site 227882012702 putative PBP binding loops; other site 227882012703 ABC-ATPase subunit interface; other site 227882012704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882012705 dimer interface [polypeptide binding]; other site 227882012706 conserved gate region; other site 227882012707 putative PBP binding loops; other site 227882012708 ABC-ATPase subunit interface; other site 227882012709 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882012710 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882012711 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882012712 DNA binding site [nucleotide binding] 227882012713 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 227882012714 putative ligand binding site [chemical binding]; other site 227882012715 putative dimerization interface [polypeptide binding]; other site 227882012716 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 227882012717 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 227882012718 putative active site [active] 227882012719 putative substrate binding site [chemical binding]; other site 227882012720 catalytic site [active] 227882012721 dimer interface [polypeptide binding]; other site 227882012722 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 227882012723 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 227882012724 conserved cys residue [active] 227882012725 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 227882012726 Ligand Binding Site [chemical binding]; other site 227882012727 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 227882012728 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 227882012729 glutaminase active site [active] 227882012730 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 227882012731 dimer interface [polypeptide binding]; other site 227882012732 active site 227882012733 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 227882012734 dimer interface [polypeptide binding]; other site 227882012735 active site 227882012736 PhoD-like phosphatase; Region: PhoD; pfam09423 227882012737 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 227882012738 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 227882012739 active site 227882012740 metal binding site [ion binding]; metal-binding site 227882012741 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within...; Region: GH20_SpHex_like; cd06568 227882012742 active site 227882012743 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 227882012744 IucA / IucC family; Region: IucA_IucC; pfam04183 227882012745 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 227882012746 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 227882012747 Siderophore biosynthesis protein domain; Region: AlcB; cl11000 227882012748 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 227882012749 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 227882012750 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 227882012751 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882012752 catalytic residue [active] 227882012753 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 227882012754 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 227882012755 FAD binding pocket [chemical binding]; other site 227882012756 FAD binding motif [chemical binding]; other site 227882012757 phosphate binding motif [ion binding]; other site 227882012758 NAD binding pocket [chemical binding]; other site 227882012759 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 227882012760 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 227882012761 intersubunit interface [polypeptide binding]; other site 227882012762 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 227882012763 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882012764 active site 227882012765 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 227882012766 active site 227882012767 catalytic residues [active] 227882012768 metal binding site [ion binding]; metal-binding site 227882012769 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 227882012770 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 227882012771 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 227882012772 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 227882012773 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 227882012774 carboxyltransferase (CT) interaction site; other site 227882012775 biotinylation site [posttranslational modification]; other site 227882012776 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 227882012777 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 227882012778 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 227882012779 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882012780 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882012781 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 227882012782 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882012783 active site 227882012784 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 227882012785 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 227882012786 active site 227882012787 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 227882012788 catalytic triad [active] 227882012789 dimer interface [polypeptide binding]; other site 227882012790 Protein of unknown function (DUF1185); Region: DUF1185; pfam06684 227882012791 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 227882012792 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 227882012793 Sodium:solute symporter family; Region: SSF; cl00456 227882012794 Arginase family; Region: Arginase; cl00306 227882012795 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 227882012796 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 227882012797 PYR/PP interface [polypeptide binding]; other site 227882012798 dimer interface [polypeptide binding]; other site 227882012799 TPP binding site [chemical binding]; other site 227882012800 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 227882012801 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin...; Region: TPP_enzymes; cd00568 227882012802 TPP-binding site [chemical binding]; other site 227882012803 Endonuclease I; Region: Endonuclease_1; cl01003 227882012804 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 227882012805 Predicted membrane protein [Function unknown]; Region: COG1511 227882012806 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 227882012807 protein-splicing catalytic site; other site 227882012808 thioester formation/cholesterol transfer; other site 227882012809 Protein of unknown function (DUF1557); Region: DUF1557; pfam07591 227882012810 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882012811 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 227882012812 non-specific DNA binding site [nucleotide binding]; other site 227882012813 salt bridge; other site 227882012814 sequence-specific DNA binding site [nucleotide binding]; other site 227882012815 Beta-lactamase; Region: Beta-lactamase; cl01009 227882012816 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 227882012817 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 227882012818 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882012819 Walker A/P-loop; other site 227882012820 ATP binding site [chemical binding]; other site 227882012821 Q-loop/lid; other site 227882012822 ABC transporter signature motif; other site 227882012823 Walker B; other site 227882012824 D-loop; other site 227882012825 H-loop/switch region; other site 227882012826 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 227882012827 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 227882012828 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882012829 Walker A/P-loop; other site 227882012830 ATP binding site [chemical binding]; other site 227882012831 Q-loop/lid; other site 227882012832 ABC transporter signature motif; other site 227882012833 Walker B; other site 227882012834 D-loop; other site 227882012835 H-loop/switch region; other site 227882012836 Serine carboxypeptidase S28; Region: Peptidase_S28; cl15279 227882012837 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 227882012838 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 227882012839 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 227882012840 Transcriptional regulator [Transcription]; Region: LysR; COG0583 227882012841 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882012842 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 227882012843 putative dimerization interface [polypeptide binding]; other site 227882012844 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 227882012845 EamA-like transporter family; Region: EamA; cl01037 227882012846 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 227882012847 TIR domain; Region: TIR; cl02060 227882012848 GUN4-like; Region: GUN4; pfam05419 227882012849 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882012850 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 227882012851 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 227882012852 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882012853 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 227882012854 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 227882012855 Coenzyme A binding pocket [chemical binding]; other site 227882012856 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882012857 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882012858 DNA binding site [nucleotide binding] 227882012859 domain linker motif; other site 227882012860 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 227882012861 dimerization interface [polypeptide binding]; other site 227882012862 ligand binding site [chemical binding]; other site 227882012863 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 227882012864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882012865 Protein of unknown function (DUF993); Region: DUF993; pfam06187 227882012866 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 227882012867 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 227882012868 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 227882012869 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174 227882012870 substrate binding site [chemical binding]; other site 227882012871 dimer interface [polypeptide binding]; other site 227882012872 ATP binding site [chemical binding]; other site 227882012873 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 227882012874 TM-ABC transporter signature motif; other site 227882012875 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 227882012876 ligand binding site [chemical binding]; other site 227882012877 dimerization interface [polypeptide binding]; other site 227882012878 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 227882012879 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 227882012880 Walker A/P-loop; other site 227882012881 ATP binding site [chemical binding]; other site 227882012882 Q-loop/lid; other site 227882012883 ABC transporter signature motif; other site 227882012884 Walker B; other site 227882012885 D-loop; other site 227882012886 H-loop/switch region; other site 227882012887 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 227882012888 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882012889 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882012890 DNA binding site [nucleotide binding] 227882012891 domain linker motif; other site 227882012892 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 227882012893 dimerization interface [polypeptide binding]; other site 227882012894 ligand binding site [chemical binding]; other site 227882012895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 227882012896 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 227882012897 RecD/TraA family; Region: recD_rel; TIGR01448 227882012898 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 227882012899 dimer interface [polypeptide binding]; other site 227882012900 Citrate synthase; Region: Citrate_synt; pfam00285 227882012901 active site 227882012902 citrylCoA binding site [chemical binding]; other site 227882012903 NADH binding [chemical binding]; other site 227882012904 cationic pore residues; other site 227882012905 oxalacetate/citrate binding site [chemical binding]; other site 227882012906 coenzyme A binding site [chemical binding]; other site 227882012907 catalytic triad [active] 227882012908 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 227882012909 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 227882012910 metal-binding site [ion binding] 227882012911 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 227882012912 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882012913 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 227882012914 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882012915 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882012916 MMPL family; Region: MMPL; pfam03176 227882012917 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 227882012918 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 227882012919 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 227882012920 putative NAD(P) binding site [chemical binding]; other site 227882012921 catalytic Zn binding site [ion binding]; other site 227882012922 structural Zn binding site [ion binding]; other site 227882012923 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 227882012924 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 227882012925 mannonate dehydratase; Region: uxuA; TIGR00695 227882012926 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 227882012927 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 227882012928 substrate binding site [chemical binding]; other site 227882012929 ATP binding site [chemical binding]; other site 227882012930 KduI/IolB family; Region: KduI; cl01508 227882012931 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 227882012932 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 227882012933 PYR/PP interface [polypeptide binding]; other site 227882012934 dimer interface [polypeptide binding]; other site 227882012935 TPP binding site [chemical binding]; other site 227882012936 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 227882012937 TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 227882012938 TPP-binding site; other site 227882012939 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 227882012940 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 227882012941 tetrameric interface [polypeptide binding]; other site 227882012942 NAD binding site [chemical binding]; other site 227882012943 catalytic residues [active] 227882012944 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882012945 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 227882012946 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882012947 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 227882012948 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882012949 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 227882012950 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 227882012951 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 227882012952 Walker A/P-loop; other site 227882012953 ATP binding site [chemical binding]; other site 227882012954 Q-loop/lid; other site 227882012955 ABC transporter signature motif; other site 227882012956 Walker B; other site 227882012957 D-loop; other site 227882012958 H-loop/switch region; other site 227882012959 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 227882012960 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 227882012961 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 227882012962 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 227882012963 integral membrane protein MviN; Region: mviN; TIGR01695 227882012964 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 227882012965 O-Antigen ligase; Region: Wzy_C; cl04850 227882012966 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 227882012967 Bacterial sugar transferase; Region: Bac_transf; cl00939 227882012968 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 227882012969 Tyrosinase co-factor MelC1; Region: MelC1; pfam06236 227882012970 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 227882012971 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 227882012972 G1 box; other site 227882012973 GTP/Mg2+ binding site [chemical binding]; other site 227882012974 Switch I region; other site 227882012975 G2 box; other site 227882012976 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 227882012977 G1 box; other site 227882012978 GTP/Mg2+ binding site [chemical binding]; other site 227882012979 Switch I region; other site 227882012980 G2 box; other site 227882012981 Switch II region; other site 227882012982 G3 box; other site 227882012983 G4 box; other site 227882012984 G5 box; other site 227882012985 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 227882012986 dimer interface [polypeptide binding]; other site 227882012987 ssDNA binding site [nucleotide binding]; other site 227882012988 tetramer (dimer of dimers) interface [polypeptide binding]; other site 227882012989 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14960 227882012990 TQXA domain; Region: TQXA_dom; TIGR03934 227882012991 Domain of unknown function (DUF756); Region: DUF756; pfam05506 227882012992 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 227882012993 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882012994 Walker A/P-loop; other site 227882012995 ATP binding site [chemical binding]; other site 227882012996 Q-loop/lid; other site 227882012997 ABC transporter signature motif; other site 227882012998 Walker B; other site 227882012999 D-loop; other site 227882013000 H-loop/switch region; other site 227882013001 ABC transporter; Region: ABC_tran_2; pfam12848 227882013002 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 227882013003 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 227882013004 active site 227882013005 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is...; Region: Trunc_globin; cd00454 227882013006 apolar tunnel; other site 227882013007 heme binding site [chemical binding]; other site 227882013008 dimerization interface [polypeptide binding]; other site 227882013009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882013010 S-adenosylmethionine binding site [chemical binding]; other site 227882013011 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 227882013012 phosphopeptide binding site; other site 227882013013 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 227882013014 metal ion-dependent adhesion site (MIDAS); other site 227882013015 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 227882013016 Active site [active] 227882013017 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882013018 Catalytic domain of Protein Kinases; Region: PKc; cd00180 227882013019 active site 227882013020 ATP binding site [chemical binding]; other site 227882013021 substrate binding site [chemical binding]; other site 227882013022 activation loop (A-loop); other site 227882013023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 227882013024 binding surface 227882013025 TPR motif; other site 227882013026 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 227882013027 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 227882013028 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 227882013029 substrate binding pocket [chemical binding]; other site 227882013030 membrane-bound complex binding site; other site 227882013031 hinge residues; other site 227882013032 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882013033 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 227882013034 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 227882013035 NAD binding site [chemical binding]; other site 227882013036 sugar binding site [chemical binding]; other site 227882013037 divalent metal binding site [ion binding]; other site 227882013038 tetramer (dimer of dimers) interface [polypeptide binding]; other site 227882013039 dimer interface [polypeptide binding]; other site 227882013040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882013041 dimer interface [polypeptide binding]; other site 227882013042 conserved gate region; other site 227882013043 putative PBP binding loops; other site 227882013044 ABC-ATPase subunit interface; other site 227882013045 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 227882013046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 227882013047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882013048 putative PBP binding loops; other site 227882013049 dimer interface [polypeptide binding]; other site 227882013050 ABC-ATPase subunit interface; other site 227882013051 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 227882013052 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882013053 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882013054 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882013055 mechanosensitive channel MscS; Provisional; Region: PRK10334 227882013056 Mechanosensitive ion channel; Region: MS_channel; pfam00924 227882013057 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 227882013058 active site 227882013059 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 227882013060 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 227882013061 Walker A/P-loop; other site 227882013062 ATP binding site [chemical binding]; other site 227882013063 Q-loop/lid; other site 227882013064 ABC transporter signature motif; other site 227882013065 Walker B; other site 227882013066 D-loop; other site 227882013067 H-loop/switch region; other site 227882013068 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882013069 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 227882013070 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882013071 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 227882013072 EamA-like transporter family; Region: EamA; cl01037 227882013073 EamA-like transporter family; Region: EamA; cl01037 227882013074 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 227882013075 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 227882013076 Zn binding site [ion binding]; other site 227882013077 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 227882013078 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 227882013079 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 227882013080 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882013081 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 227882013082 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 227882013083 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882013084 DNA binding residues [nucleotide binding] 227882013085 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 227882013086 active site 227882013087 catalytic residues [active] 227882013088 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 227882013089 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 227882013090 CGNR zinc finger; Region: zf-CGNR; pfam11706 227882013091 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 227882013092 putative dimer interface [polypeptide binding]; other site 227882013093 ligand binding site [chemical binding]; other site 227882013094 Zn binding site [ion binding]; other site 227882013095 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 227882013096 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X...; Region: Nudix_Hydrolase_25; cd04684 227882013097 nudix motif; other site 227882013098 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 227882013099 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882013100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882013101 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 227882013102 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 227882013103 Zn binding site [ion binding]; other site 227882013104 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 227882013105 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 227882013106 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 227882013107 catalytic residues [active] 227882013108 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 227882013109 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 227882013110 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 227882013111 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882013112 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 227882013113 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 227882013114 active site 227882013115 iron coordination sites [ion binding]; other site 227882013116 substrate binding pocket [chemical binding]; other site 227882013117 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 227882013118 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 227882013119 active site 227882013120 non-prolyl cis peptide bond; other site 227882013121 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 227882013122 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 227882013123 Walker A/P-loop; other site 227882013124 ATP binding site [chemical binding]; other site 227882013125 Q-loop/lid; other site 227882013126 ABC transporter signature motif; other site 227882013127 Walker B; other site 227882013128 D-loop; other site 227882013129 H-loop/switch region; other site 227882013130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882013131 dimer interface [polypeptide binding]; other site 227882013132 conserved gate region; other site 227882013133 putative PBP binding loops; other site 227882013134 ABC-ATPase subunit interface; other site 227882013135 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 227882013136 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 227882013137 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 227882013138 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882013139 BioY family; Region: BioY; cl00560 227882013140 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 227882013141 FAD binding domain; Region: FAD_binding_4; pfam01565 227882013142 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882013143 Catalytic domain of Protein Kinases; Region: PKc; cd00180 227882013144 active site 227882013145 ATP binding site [chemical binding]; other site 227882013146 substrate binding site [chemical binding]; other site 227882013147 activation loop (A-loop); other site 227882013148 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882013149 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 227882013150 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 227882013151 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 227882013152 putative DNA binding site [nucleotide binding]; other site 227882013153 catalytic residue [active] 227882013154 putative H2TH interface [polypeptide binding]; other site 227882013155 putative catalytic residues [active] 227882013156 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 227882013157 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 227882013158 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882013159 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 227882013160 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882013161 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 227882013162 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 227882013163 Walker A/P-loop; other site 227882013164 ATP binding site [chemical binding]; other site 227882013165 Q-loop/lid; other site 227882013166 ABC transporter signature motif; other site 227882013167 Walker B; other site 227882013168 D-loop; other site 227882013169 H-loop/switch region; other site 227882013170 FtsX-like permease family; Region: FtsX; pfam02687 227882013171 FtsX-like permease family; Region: FtsX; pfam02687 227882013172 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators...; Region: VIP2; cl00173 227882013173 active site 227882013174 conformational flexibility of ligand binding pocket; other site 227882013175 ADP-ribosylating toxin turn-turn motif; other site 227882013176 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 227882013177 secretion protein snm4; Region: sec_mycoba_snm4; TIGR02958 227882013178 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 227882013179 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 227882013180 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 227882013181 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882013182 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 227882013183 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882013184 Predicted O-acyltransferase [General function prediction only]; Region: COG3274; cl00792 227882013185 trigger factor; Provisional; Region: tig; PRK01490 227882013186 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 227882013187 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 227882013188 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 227882013189 oligomer interface [polypeptide binding]; other site 227882013190 active site residues [active] 227882013191 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 227882013192 oligomer interface [polypeptide binding]; other site 227882013193 active site residues [active] 227882013194 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 227882013195 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 227882013196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882013197 Walker A motif; other site 227882013198 ATP binding site [chemical binding]; other site 227882013199 Walker B motif; other site 227882013200 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 227882013201 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 227882013202 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 227882013203 active site 227882013204 HIGH motif; other site 227882013205 nucleotide binding site [chemical binding]; other site 227882013206 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 227882013207 active site 227882013208 KMSKS motif; other site 227882013209 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 227882013210 tRNA binding surface [nucleotide binding]; other site 227882013211 anticodon binding site; other site 227882013212 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 227882013213 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 227882013214 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 227882013215 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 227882013216 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 227882013217 active site 227882013218 multimer interface [polypeptide binding]; other site 227882013219 rod shape-determining protein MreB; Provisional; Region: PRK13927 227882013220 Cell division protein FtsA; Region: FtsA; cl11496 227882013221 rod shape-determining protein MreC; Region: MreC; pfam04085 227882013222 rod shape-determining protein MreD; Region: MreD; cl01087 227882013223 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 227882013224 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 227882013225 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 227882013226 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 227882013227 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 227882013228 putative active site; other site 227882013229 putative metal binding residues [ion binding]; other site 227882013230 signature motif; other site 227882013231 putative triphosphate binding site [ion binding]; other site 227882013232 CHAD domain; Region: CHAD; cl10506 227882013233 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 227882013234 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 227882013235 FeS/SAM binding site; other site 227882013236 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 227882013237 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 227882013238 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 227882013239 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 227882013240 homodimer interface [polypeptide binding]; other site 227882013241 oligonucleotide binding site [chemical binding]; other site 227882013242 Putative catalytic domain, repeat 1, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_1; cd09172 227882013243 putative active site [active] 227882013244 catalytic site [active] 227882013245 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 227882013246 putative active site [active] 227882013247 catalytic site [active] 227882013248 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 227882013249 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 227882013250 GTPase CgtA; Reviewed; Region: obgE; PRK12296 227882013251 GTP1/OBG; Region: GTP1_OBG; pfam01018 227882013252 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 227882013253 G1 box; other site 227882013254 GTP/Mg2+ binding site [chemical binding]; other site 227882013255 Switch I region; other site 227882013256 G2 box; other site 227882013257 G3 box; other site 227882013258 Switch II region; other site 227882013259 G4 box; other site 227882013260 G5 box; other site 227882013261 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 227882013262 gamma-glutamyl kinase; Provisional; Region: PRK05429 227882013263 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 227882013264 nucleotide binding site [chemical binding]; other site 227882013265 substrate binding site [chemical binding]; other site 227882013266 PUA domain; Region: PUA; cl00607 227882013267 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 227882013268 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 227882013269 putative catalytic cysteine [active] 227882013270 Peptidase family M48; Region: Peptidase_M48; cl12018 227882013271 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 227882013272 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 227882013273 active site 227882013274 (T/H)XGH motif; other site 227882013275 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 227882013276 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 227882013277 Domain of unknown function DUF143; Region: DUF143; cl00519 227882013278 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 227882013279 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 227882013280 catalytic core [active] 227882013281 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882013282 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 227882013283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882013284 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 227882013285 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 227882013286 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 227882013287 SLBB domain; Region: SLBB; pfam10531 227882013288 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 227882013289 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 227882013290 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 227882013291 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 227882013292 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 227882013293 active site 227882013294 HIGH motif; other site 227882013295 nucleotide binding site [chemical binding]; other site 227882013296 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 227882013297 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 227882013298 active site 227882013299 KMSKS motif; other site 227882013300 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 227882013301 tRNA binding surface [nucleotide binding]; other site 227882013302 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 227882013303 SLBB domain; Region: SLBB; pfam10531 227882013304 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 227882013305 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 227882013306 Competence protein; Region: Competence; cl00471 227882013307 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 227882013308 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 227882013309 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882013310 DNA-binding site [nucleotide binding]; DNA binding site 227882013311 UTRA domain; Region: UTRA; cl01230 227882013312 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 227882013313 amidase catalytic site [active] 227882013314 Zn binding residues [ion binding]; other site 227882013315 substrate binding site [chemical binding]; other site 227882013316 Phage tail protein; Region: Sipho_tail; cl11462 227882013317 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 227882013318 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 227882013319 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 227882013320 Phage terminase large subunit; Region: Terminase_3; cl12054 227882013321 Terminase-like family; Region: Terminase_6; pfam03237 227882013322 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 227882013323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882013324 cofactor binding site; other site 227882013325 DNA binding site [nucleotide binding] 227882013326 substrate interaction site [chemical binding]; other site 227882013327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882013328 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882013329 BRO family, N-terminal domain; Region: Bro-N; cl10591 227882013330 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 227882013331 catalytic residues [active] 227882013332 catalytic nucleophile [active] 227882013333 Recombinase; Region: Recombinase; pfam07508 227882013334 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882013335 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882013336 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 227882013337 catalytic residues [active] 227882013338 catalytic nucleophile [active] 227882013339 Recombinase; Region: Recombinase; pfam07508 227882013340 N-acetyltransferase; Region: Acetyltransf_2; cl00949 227882013341 hypothetical protein; Reviewed; Region: PRK07914 227882013342 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 227882013343 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 227882013344 GTP-binding protein LepA; Provisional; Region: PRK05433 227882013345 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 227882013346 G1 box; other site 227882013347 putative GEF interaction site [polypeptide binding]; other site 227882013348 GTP/Mg2+ binding site [chemical binding]; other site 227882013349 Switch I region; other site 227882013350 G2 box; other site 227882013351 G3 box; other site 227882013352 Switch II region; other site 227882013353 G4 box; other site 227882013354 G5 box; other site 227882013355 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 227882013356 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 227882013357 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 227882013358 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 227882013359 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882013360 Response regulator receiver domain; Region: Response_reg; pfam00072 227882013361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882013362 active site 227882013363 phosphorylation site [posttranslational modification] 227882013364 intermolecular recognition site; other site 227882013365 dimerization interface [polypeptide binding]; other site 227882013366 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882013367 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 227882013368 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882013369 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882013370 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882013371 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882013372 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882013373 GAF domain; Region: GAF; cl00853 227882013374 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cl00080 227882013375 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882013376 ATP binding site [chemical binding]; other site 227882013377 Mg2+ binding site [ion binding]; other site 227882013378 G-X-G motif; other site 227882013379 Response regulator receiver domain; Region: Response_reg; pfam00072 227882013380 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882013381 active site 227882013382 phosphorylation site [posttranslational modification] 227882013383 intermolecular recognition site; other site 227882013384 dimerization interface [polypeptide binding]; other site 227882013385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882013386 GAF domain; Region: GAF; cl00853 227882013387 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882013388 coproporphyrinogen III oxidase; Validated; Region: PRK05628 227882013389 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 227882013390 FeS/SAM binding site; other site 227882013391 HemN C-terminal region; Region: HemN_C; pfam06969 227882013392 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 227882013393 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 227882013394 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 227882013395 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882013396 HrcA protein C terminal domain; Region: HrcA; pfam01628 227882013397 chaperone protein DnaJ; Provisional; Region: PRK14278 227882013398 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 227882013399 HSP70 interaction site [polypeptide binding]; other site 227882013400 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 227882013401 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 227882013402 Nitronate monooxygenase; Region: NMO; pfam03060 227882013403 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 227882013404 FMN binding site [chemical binding]; other site 227882013405 substrate binding site [chemical binding]; other site 227882013406 putative catalytic residue [active] 227882013407 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 227882013408 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 227882013409 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 227882013410 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 227882013411 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 227882013412 protein binding site [polypeptide binding]; other site 227882013413 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 227882013414 Domain interface; other site 227882013415 Peptide binding site; other site 227882013416 Active site tetrad [active] 227882013417 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 227882013418 nucleotide binding site/active site [active] 227882013419 HIT family signature motif; other site 227882013420 catalytic residue [active] 227882013421 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 227882013422 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 227882013423 active site 227882013424 purine riboside binding site [chemical binding]; other site 227882013425 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882013426 Transcriptional regulator [Transcription]; Region: IclR; COG1414 227882013427 Bacterial transcriptional regulator; Region: IclR; pfam01614 227882013428 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 227882013429 dihydrodipicolinate synthase; Region: dapA; TIGR00674 227882013430 catalytic residue [active] 227882013431 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of...; Region: D-glucarate_dehydratase; cd03323 227882013432 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 227882013433 active site 227882013434 tetramer interface [polypeptide binding]; other site 227882013435 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 227882013436 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 227882013437 substrate binding site [chemical binding]; other site 227882013438 ATP binding site [chemical binding]; other site 227882013439 PhoH-like protein; Region: PhoH; cl12134 227882013440 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 227882013441 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 227882013442 Domain of unknown function DUF21; Region: DUF21; pfam01595 227882013443 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 227882013444 Transporter associated domain; Region: CorC_HlyC; cl08393 227882013445 Protein of unknown function (DUF419); Region: DUF419; cl15265 227882013446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882013447 Major Facilitator Superfamily; Region: MFS_1; pfam07690 227882013448 putative substrate translocation pore; other site 227882013449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882013450 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882013451 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 227882013452 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 227882013453 GTPase Era; Reviewed; Region: era; PRK00089 227882013454 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 227882013455 G1 box; other site 227882013456 GTP/Mg2+ binding site [chemical binding]; other site 227882013457 Switch I region; other site 227882013458 G2 box; other site 227882013459 Switch II region; other site 227882013460 G3 box; other site 227882013461 G4 box; other site 227882013462 G5 box; other site 227882013463 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 227882013464 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 227882013465 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 227882013466 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 227882013467 active site 227882013468 Zn binding site [ion binding]; other site 227882013469 2-isopropylmalate synthase; Validated; Region: PRK03739 227882013470 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 227882013471 active site 227882013472 catalytic residues [active] 227882013473 metal binding site [ion binding]; metal-binding site 227882013474 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 227882013475 tellurium resistance terB-like protein; Region: terB_like; cl11965 227882013476 metal binding site [ion binding]; metal-binding site 227882013477 MMPL family; Region: MMPL; pfam03176 227882013478 Transport protein; Region: actII; TIGR00833 227882013479 Histidine kinase; Region: HisKA_3; pfam07730 227882013480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882013481 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882013482 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882013483 active site 227882013484 phosphorylation site [posttranslational modification] 227882013485 intermolecular recognition site; other site 227882013486 dimerization interface [polypeptide binding]; other site 227882013487 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882013488 DNA binding residues [nucleotide binding] 227882013489 dimerization interface [polypeptide binding]; other site 227882013490 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 227882013491 catalytic site [active] 227882013492 Asp-box motif; other site 227882013493 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 227882013494 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 227882013495 active site 227882013496 inhibitor site; inhibition site 227882013497 dimer interface [polypeptide binding]; other site 227882013498 catalytic residue [active] 227882013499 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 227882013500 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 227882013501 Walker A/P-loop; other site 227882013502 ATP binding site [chemical binding]; other site 227882013503 Q-loop/lid; other site 227882013504 ABC transporter signature motif; other site 227882013505 Walker B; other site 227882013506 D-loop; other site 227882013507 H-loop/switch region; other site 227882013508 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 227882013509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882013510 dimer interface [polypeptide binding]; other site 227882013511 ABC-ATPase subunit interface; other site 227882013512 putative PBP binding loops; other site 227882013513 cystic fibrosis transmembrane conductor regulator (CFTR); Region: CFTR_protein; TIGR01271 227882013514 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 227882013515 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 227882013516 Walker A/P-loop; other site 227882013517 ATP binding site [chemical binding]; other site 227882013518 Q-loop/lid; other site 227882013519 ABC transporter signature motif; other site 227882013520 Walker B; other site 227882013521 D-loop; other site 227882013522 H-loop/switch region; other site 227882013523 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 227882013524 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 227882013525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 227882013526 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 227882013527 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 227882013528 Transcriptional regulators [Transcription]; Region: FadR; COG2186 227882013529 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882013530 DNA-binding site [nucleotide binding]; DNA binding site 227882013531 FCD domain; Region: FCD; cl11656 227882013532 multidrug efflux protein NorA; Provisional; Region: PRK00187 227882013533 MatE; Region: MatE; cl10513 227882013534 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 227882013535 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 227882013536 dimer interface [polypeptide binding]; other site 227882013537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882013538 catalytic residue [active] 227882013539 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 227882013540 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 227882013541 active site 227882013542 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 227882013543 dimer interface [polypeptide binding]; other site 227882013544 catalytic residues [active] 227882013545 substrate binding site [chemical binding]; other site 227882013546 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 227882013547 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882013548 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 227882013549 substrate binding pocket [chemical binding]; other site 227882013550 active site 227882013551 iron coordination sites [ion binding]; other site 227882013552 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 227882013553 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 227882013554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882013555 dimer interface [polypeptide binding]; other site 227882013556 conserved gate region; other site 227882013557 putative PBP binding loops; other site 227882013558 ABC-ATPase subunit interface; other site 227882013559 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 227882013560 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 227882013561 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 227882013562 Walker A/P-loop; other site 227882013563 ATP binding site [chemical binding]; other site 227882013564 Q-loop/lid; other site 227882013565 ABC transporter signature motif; other site 227882013566 Walker B; other site 227882013567 D-loop; other site 227882013568 H-loop/switch region; other site 227882013569 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 227882013570 Walker A/P-loop; other site 227882013571 ATP binding site [chemical binding]; other site 227882013572 Q-loop/lid; other site 227882013573 ABC transporter signature motif; other site 227882013574 Walker B; other site 227882013575 D-loop; other site 227882013576 H-loop/switch region; other site 227882013577 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 227882013578 Histidine kinase; Region: HisKA_3; pfam07730 227882013579 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882013580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882013581 active site 227882013582 phosphorylation site [posttranslational modification] 227882013583 intermolecular recognition site; other site 227882013584 dimerization interface [polypeptide binding]; other site 227882013585 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882013586 DNA binding residues [nucleotide binding] 227882013587 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882013588 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882013589 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 227882013590 Recombination protein O N terminal; Region: RecO_N; pfam11967 227882013591 Recombination protein O C terminal; Region: RecO_C; pfam02565 227882013592 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 227882013593 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 227882013594 catalytic residue [active] 227882013595 putative FPP diphosphate binding site; other site 227882013596 putative FPP binding hydrophobic cleft; other site 227882013597 dimer interface [polypeptide binding]; other site 227882013598 putative IPP diphosphate binding site; other site 227882013599 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 227882013600 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 227882013601 active site 227882013602 Zn binding site [ion binding]; other site 227882013603 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 227882013604 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 227882013605 metal binding site 2 [ion binding]; metal-binding site 227882013606 putative DNA binding helix; other site 227882013607 metal binding site 1 [ion binding]; metal-binding site 227882013608 dimer interface [polypeptide binding]; other site 227882013609 structural Zn2+ binding site [ion binding]; other site 227882013610 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 227882013611 ABC-ATPase subunit interface; other site 227882013612 dimer interface [polypeptide binding]; other site 227882013613 putative PBP binding regions; other site 227882013614 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 227882013615 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 227882013616 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 227882013617 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 227882013618 metal binding site [ion binding]; metal-binding site 227882013619 glycyl-tRNA synthetase; Provisional; Region: PRK04173 227882013620 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 227882013621 motif 1; other site 227882013622 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the...; Region: GlyRS-like_core; cd00774 227882013623 active site 227882013624 motif 2; other site 227882013625 motif 3; other site 227882013626 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 227882013627 anticodon binding site; other site 227882013628 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18 (...; Region: GH18_chitinase_D-like; cd02871 227882013629 putative active site [active] 227882013630 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 227882013631 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 227882013632 active site 227882013633 catalytic tetrad [active] 227882013634 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882013635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882013636 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 227882013637 Leucine carboxyl methyltransferase; Region: LCM; cl01306 227882013638 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 227882013639 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882013640 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882013641 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 227882013642 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 227882013643 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 227882013644 Major Facilitator Superfamily; Region: MFS_1; pfam07690 227882013645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882013646 putative substrate translocation pore; other site 227882013647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882013648 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 227882013649 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 227882013650 FMN binding site [chemical binding]; other site 227882013651 active site 227882013652 catalytic residues [active] 227882013653 substrate binding site [chemical binding]; other site 227882013654 Sulfatase; Region: Sulfatase; cl10460 227882013655 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 227882013656 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 227882013657 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 227882013658 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882013659 pyruvate phosphate dikinase; Provisional; Region: PRK09279 227882013660 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 227882013661 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 227882013662 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 227882013663 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 227882013664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882013665 ATP binding site [chemical binding]; other site 227882013666 Mg2+ binding site [ion binding]; other site 227882013667 G-X-G motif; other site 227882013668 Response regulator receiver domain; Region: Response_reg; pfam00072 227882013669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882013670 active site 227882013671 phosphorylation site [posttranslational modification] 227882013672 intermolecular recognition site; other site 227882013673 dimerization interface [polypeptide binding]; other site 227882013674 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882013675 DNA binding site [nucleotide binding] 227882013676 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 227882013677 active site clefts [active] 227882013678 zinc binding site [ion binding]; other site 227882013679 dimer interface [polypeptide binding]; other site 227882013680 Sulfate transporter family; Region: Sulfate_transp; cl00967 227882013681 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 227882013682 short chain dehydrogenase; Provisional; Region: PRK06197 227882013683 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 227882013684 putative NAD(P) binding site [chemical binding]; other site 227882013685 active site 227882013686 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain...; Region: Rieske_NirD; cd03529 227882013687 nitrite reductase subunit NirD; Provisional; Region: PRK14989 227882013688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882013689 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 227882013690 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 227882013691 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 227882013692 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan...; Region: Sortase_E; cd05829 227882013693 active site 227882013694 putative catalytic site [active] 227882013695 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 227882013696 YceI-like domain; Region: YceI; cl01001 227882013697 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882013698 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882013699 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 227882013700 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 227882013701 active site 227882013702 Zn binding site [ion binding]; other site 227882013703 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 227882013704 putative active site pocket [active] 227882013705 dimerization interface [polypeptide binding]; other site 227882013706 putative catalytic residue [active] 227882013707 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 227882013708 putative active site [active] 227882013709 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 227882013710 putative active site [active] 227882013711 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416 227882013712 putative active site [active] 227882013713 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 227882013714 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 227882013715 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882013716 DNA primase, catalytic core; Region: dnaG; TIGR01391 227882013717 CHC2 zinc finger; Region: zf-CHC2; cl02597 227882013718 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 227882013719 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 227882013720 active site 227882013721 metal binding site [ion binding]; metal-binding site 227882013722 interdomain interaction site; other site 227882013723 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 227882013724 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 227882013725 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 227882013726 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 227882013727 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 227882013728 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882013729 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 227882013730 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882013731 DNA binding residues [nucleotide binding] 227882013732 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 227882013733 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 227882013734 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 227882013735 Walker A/P-loop; other site 227882013736 ATP binding site [chemical binding]; other site 227882013737 Q-loop/lid; other site 227882013738 ABC transporter signature motif; other site 227882013739 Walker B; other site 227882013740 D-loop; other site 227882013741 H-loop/switch region; other site 227882013742 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 227882013743 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 227882013744 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882013745 Walker A/P-loop; other site 227882013746 ATP binding site [chemical binding]; other site 227882013747 Q-loop/lid; other site 227882013748 ABC transporter signature motif; other site 227882013749 Walker B; other site 227882013750 D-loop; other site 227882013751 H-loop/switch region; other site 227882013752 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 227882013753 N- and C-terminal domain interface [polypeptide binding]; other site 227882013754 MgATP binding site [chemical binding]; other site 227882013755 active site 227882013756 catalytic site [active] 227882013757 metal binding site [ion binding]; metal-binding site 227882013758 carbohydrate binding site [chemical binding]; other site 227882013759 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 227882013760 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 227882013761 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882013762 Walker A/P-loop; other site 227882013763 ATP binding site [chemical binding]; other site 227882013764 Q-loop/lid; other site 227882013765 ABC transporter signature motif; other site 227882013766 Walker B; other site 227882013767 D-loop; other site 227882013768 H-loop/switch region; other site 227882013769 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 227882013770 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 227882013771 Ligand Binding Site [chemical binding]; other site 227882013772 Molecular Tunnel; other site 227882013773 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 227882013774 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 227882013775 putative active site [active] 227882013776 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 227882013777 ATP-dependent helicase HepA; Validated; Region: PRK04914 227882013778 Predicted GTPases [General function prediction only]; Region: COG1161 227882013779 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 227882013780 G1 box; other site 227882013781 GTP/Mg2+ binding site [chemical binding]; other site 227882013782 Switch I region; other site 227882013783 G2 box; other site 227882013784 Switch II region; other site 227882013785 G3 box; other site 227882013786 G4 box; other site 227882013787 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 227882013788 G1 box; other site 227882013789 GTP/Mg2+ binding site [chemical binding]; other site 227882013790 Switch I region; other site 227882013791 G2 box; other site 227882013792 Switch II region; other site 227882013793 G3 box; other site 227882013794 G4 box; other site 227882013795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882013796 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 227882013797 ligand binding site [chemical binding]; other site 227882013798 flexible hinge region; other site 227882013799 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882013800 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882013801 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882013802 DNA binding site [nucleotide binding] 227882013803 domain linker motif; other site 227882013804 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 227882013805 dimerization interface [polypeptide binding]; other site 227882013806 ligand binding site [chemical binding]; other site 227882013807 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 227882013808 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882013809 Walker A/P-loop; other site 227882013810 ATP binding site [chemical binding]; other site 227882013811 Q-loop/lid; other site 227882013812 ABC transporter signature motif; other site 227882013813 Walker B; other site 227882013814 D-loop; other site 227882013815 H-loop/switch region; other site 227882013816 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 227882013817 TM-ABC transporter signature motif; other site 227882013818 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 227882013819 ligand binding site [chemical binding]; other site 227882013820 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 227882013821 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 227882013822 putative substrate binding site [chemical binding]; other site 227882013823 putative ATP binding site [chemical binding]; other site 227882013824 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 227882013825 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 227882013826 active site 227882013827 catalytic triad [active] 227882013828 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 227882013829 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882013830 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 227882013831 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 227882013832 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882013833 TIR domain; Region: TIR; cl02060 227882013834 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 227882013835 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 227882013836 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 227882013837 FeS/SAM binding site; other site 227882013838 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 227882013839 GAF domain; Region: GAF; cl00853 227882013840 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 227882013841 Histidine kinase; Region: HisKA_3; pfam07730 227882013842 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 227882013843 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 227882013844 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 227882013845 active site 227882013846 catalytic residues [active] 227882013847 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 227882013848 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 227882013849 acyl-CoA synthetase; Validated; Region: PRK07787 227882013850 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882013851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882013852 Cupin domain; Region: Cupin_2; cl09118 227882013853 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 227882013854 DNA binding residues [nucleotide binding] 227882013855 drug binding residues [chemical binding]; other site 227882013856 dimer interface [polypeptide binding]; other site 227882013857 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 227882013858 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 227882013859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882013860 Trm112p-like protein; Region: Trm112p; cl01066 227882013861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882013862 S-adenosylmethionine binding site [chemical binding]; other site 227882013863 Uncharacterized protein containing a NRPS condensation (elongation) domain [General function prediction only]; Region: COG4908 227882013864 Condensation domain; Region: Condensation; cl09290 227882013865 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 227882013866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882013867 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 227882013868 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 227882013869 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 227882013870 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882013871 Transcriptional regulator [Transcription]; Region: IclR; COG1414 227882013872 Bacterial transcriptional regulator; Region: IclR; pfam01614 227882013873 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 227882013874 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 227882013875 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 227882013876 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 227882013877 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 227882013878 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 227882013879 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 227882013880 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 227882013881 Histidine kinase; Region: HisKA_3; pfam07730 227882013882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882013883 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882013884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882013885 active site 227882013886 phosphorylation site [posttranslational modification] 227882013887 intermolecular recognition site; other site 227882013888 dimerization interface [polypeptide binding]; other site 227882013889 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882013890 DNA binding residues [nucleotide binding] 227882013891 dimerization interface [polypeptide binding]; other site 227882013892 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882013893 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882013894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882013895 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 227882013896 Beta-galactosidase, domain 2; Region: BetaGal_dom2; cl11086 227882013897 Rrf2 family protein; Region: rrf2_super; TIGR00738 227882013898 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882013899 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 227882013900 putative active site [active] 227882013901 hypothetical protein; Provisional; Region: PRK06753 227882013902 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882013903 salicylate hydroxylase; Provisional; Region: PRK08163 227882013904 tetracycline repressor protein TetR; Provisional; Region: PRK13756 227882013905 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882013906 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 227882013907 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 227882013908 putative active site [active] 227882013909 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882013910 Walker A/P-loop; other site 227882013911 ATP binding site [chemical binding]; other site 227882013912 Q-loop/lid; other site 227882013913 ABC transporter signature motif; other site 227882013914 Beta-lactamase; Region: Beta-lactamase; cl01009 227882013915 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 227882013916 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 227882013917 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 227882013918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882013919 homodimer interface [polypeptide binding]; other site 227882013920 catalytic residue [active] 227882013921 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 227882013922 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 227882013923 active site 227882013924 catalytic residues [active] 227882013925 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 227882013926 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 227882013927 TM-ABC transporter signature motif; other site 227882013928 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 227882013929 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 227882013930 Walker A/P-loop; other site 227882013931 ATP binding site [chemical binding]; other site 227882013932 Q-loop/lid; other site 227882013933 ABC transporter signature motif; other site 227882013934 Walker B; other site 227882013935 D-loop; other site 227882013936 H-loop/switch region; other site 227882013937 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 227882013938 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 227882013939 putative ligand binding site [chemical binding]; other site 227882013940 Peptidase family U32; Region: Peptidase_U32; cl03113 227882013941 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 227882013942 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 227882013943 NAD(P) binding site [chemical binding]; other site 227882013944 galactonate dehydratase; Provisional; Region: PRK14017 227882013945 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues...; Region: MR_like; cd03316 227882013946 active site pocket [active] 227882013947 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882013948 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 227882013949 Prostaglandin dehydrogenases; Region: PGDH; cd05288 227882013950 NAD(P) binding site [chemical binding]; other site 227882013951 substrate binding site [chemical binding]; other site 227882013952 dimer interface [polypeptide binding]; other site 227882013953 Beta-lactamase; Region: Beta-lactamase; cl01009 227882013954 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 227882013955 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 227882013956 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 227882013957 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 227882013958 active site 227882013959 catalytic residues [active] 227882013960 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 227882013961 active site 227882013962 catalytic triad [active] 227882013963 oxyanion hole [active] 227882013964 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 227882013965 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 227882013966 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 227882013967 dimer interface [polypeptide binding]; other site 227882013968 active site 227882013969 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882013970 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 227882013971 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 227882013972 dimer interface [polypeptide binding]; other site 227882013973 active site 227882013974 CoA binding pocket [chemical binding]; other site 227882013975 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882013976 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882013977 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 227882013978 Pirin-related protein [General function prediction only]; Region: COG1741 227882013979 Cupin domain; Region: Cupin_2; cl09118 227882013980 Beta-lactamase; Region: Beta-lactamase; cl01009 227882013981 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 227882013982 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 227882013983 DNA binding residues [nucleotide binding] 227882013984 putative dimer interface [polypeptide binding]; other site 227882013985 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 227882013986 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 227882013987 active site 227882013988 catalytic tetrad [active] 227882013989 Alpha/beta hydrolase of unknown function (DUF1023); Region: DUF1023; pfam06259 227882013990 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 227882013991 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882013992 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 227882013993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882013994 putative substrate translocation pore; other site 227882013995 Ion channel; Region: Ion_trans_2; cl11596 227882013996 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 227882013997 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 227882013998 dimer interface [polypeptide binding]; other site 227882013999 TPP-binding site [chemical binding]; other site 227882014000 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 227882014001 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 227882014002 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 227882014003 dimer interface [polypeptide binding]; other site 227882014004 catalytic triad [active] 227882014005 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 227882014006 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 227882014007 putative metal binding site [ion binding]; other site 227882014008 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 227882014009 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 227882014010 putative metal binding site [ion binding]; other site 227882014011 Integral membrane protein TerC family; Region: TerC; cl10468 227882014012 Tellurium resistance protein; Region: Tellurium_res; pfam10138 227882014013 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 227882014014 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 227882014015 putative metal binding site [ion binding]; other site 227882014016 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 227882014017 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 227882014018 putative metal binding site [ion binding]; other site 227882014019 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 227882014020 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 227882014021 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 227882014022 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 227882014023 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 227882014024 DNA binding site [nucleotide binding] 227882014025 active site 227882014026 Int/Topo IB signature motif; other site 227882014027 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 227882014028 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882014029 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 227882014030 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 227882014031 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 227882014032 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 227882014033 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 227882014034 DoxX; Region: DoxX; cl00976 227882014035 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 227882014036 putative active site [active] 227882014037 putative metal binding site [ion binding]; other site 227882014038 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 227882014039 Domain of unknown function (DUF1994); Region: DUF1994; pfam09352 227882014040 Predicted membrane protein [Function unknown]; Region: COG2119 227882014041 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 227882014042 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 227882014043 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 227882014044 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 227882014045 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 227882014046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882014047 putative substrate translocation pore; other site 227882014048 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 227882014049 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 227882014050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882014051 S-adenosylmethionine binding site [chemical binding]; other site 227882014052 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 227882014053 metabolite-proton symporter; Region: 2A0106; TIGR00883 227882014054 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882014055 putative substrate translocation pore; other site 227882014056 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 227882014057 Cytochrome P450; Region: p450; cl12078 227882014058 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 227882014059 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 227882014060 dimer interface [polypeptide binding]; other site 227882014061 active site 227882014062 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 227882014063 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 227882014064 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 227882014065 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 227882014066 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 227882014067 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 227882014068 Walker A/P-loop; other site 227882014069 ATP binding site [chemical binding]; other site 227882014070 Q-loop/lid; other site 227882014071 ABC transporter signature motif; other site 227882014072 Walker B; other site 227882014073 D-loop; other site 227882014074 H-loop/switch region; other site 227882014075 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882014076 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 227882014077 Walker A/P-loop; other site 227882014078 ATP binding site [chemical binding]; other site 227882014079 Q-loop/lid; other site 227882014080 ABC transporter signature motif; other site 227882014081 Walker B; other site 227882014082 D-loop; other site 227882014083 H-loop/switch region; other site 227882014084 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 227882014085 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 227882014086 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 227882014087 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 227882014088 NAD binding site [chemical binding]; other site 227882014089 catalytic residues [active] 227882014090 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 227882014091 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 227882014092 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882014093 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882014094 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 227882014095 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 227882014096 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882014097 S-adenosylmethionine binding site [chemical binding]; other site 227882014098 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 227882014099 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 227882014100 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 227882014101 active site 227882014102 metal binding site [ion binding]; metal-binding site 227882014103 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 227882014104 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 227882014105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882014106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882014107 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 227882014108 lipid-transfer protein; Provisional; Region: PRK08256 227882014109 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 227882014110 active site 227882014111 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 227882014112 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882014113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882014114 active site 227882014115 phosphorylation site [posttranslational modification] 227882014116 intermolecular recognition site; other site 227882014117 dimerization interface [polypeptide binding]; other site 227882014118 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882014119 DNA binding residues [nucleotide binding] 227882014120 dimerization interface [polypeptide binding]; other site 227882014121 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 227882014122 Histidine kinase; Region: HisKA_3; pfam07730 227882014123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882014124 enoyl-CoA hydratase; Region: PLN02864 227882014125 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 227882014126 dimer interaction site [polypeptide binding]; other site 227882014127 substrate-binding tunnel; other site 227882014128 active site 227882014129 catalytic site [active] 227882014130 substrate binding site [chemical binding]; other site 227882014131 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 227882014132 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 227882014133 NAD binding site [chemical binding]; other site 227882014134 catalytic Zn binding site [ion binding]; other site 227882014135 substrate binding site [chemical binding]; other site 227882014136 structural Zn binding site [ion binding]; other site 227882014137 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 227882014138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882014139 NAD(P) binding site [chemical binding]; other site 227882014140 active site 227882014141 Uncharacterized conserved protein [Function unknown]; Region: COG0327 227882014142 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 227882014143 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 227882014144 Putative zinc ribbon domain; Region: DUF164; pfam02591 227882014145 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 227882014146 RNA/DNA hybrid binding site [nucleotide binding]; other site 227882014147 active site 227882014148 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 227882014149 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 227882014150 catalytic core [active] 227882014151 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 227882014152 active site 227882014153 intersubunit interface [polypeptide binding]; other site 227882014154 catalytic residue [active] 227882014155 Protein of unknown function (DUF328); Region: DUF328; cl01143 227882014156 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 227882014157 RNB domain; Region: RNB; pfam00773 227882014158 Cupin domain; Region: Cupin_2; cl09118 227882014159 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 227882014160 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882014161 EamA-like transporter family; Region: EamA; cl01037 227882014162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882014163 glutathione synthetase; Provisional; Region: PRK05246 227882014164 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 227882014165 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 227882014166 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 227882014167 Leucine carboxyl methyltransferase; Region: LCM; cl01306 227882014168 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 227882014169 mce related protein; Region: MCE; pfam02470 227882014170 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 227882014171 mce related protein; Region: MCE; pfam02470 227882014172 mce related protein; Region: MCE; pfam02470 227882014173 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 227882014174 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 227882014175 mce related protein; Region: MCE; pfam02470 227882014176 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 227882014177 mce related protein; Region: MCE; pfam02470 227882014178 mce related protein; Region: MCE; pfam02470 227882014179 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 227882014180 Domain of unknown function DUF140; Region: DUF140; cl00510 227882014181 Domain of unknown function DUF140; Region: DUF140; cl00510 227882014182 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 227882014183 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 227882014184 Walker A/P-loop; other site 227882014185 ATP binding site [chemical binding]; other site 227882014186 Q-loop/lid; other site 227882014187 ABC transporter signature motif; other site 227882014188 Walker B; other site 227882014189 D-loop; other site 227882014190 H-loop/switch region; other site 227882014191 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 227882014192 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882014193 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 227882014194 N-acetyl-D-glucosamine binding site [chemical binding]; other site 227882014195 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 227882014196 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 227882014197 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 227882014198 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 227882014199 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 227882014200 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 227882014201 Walker A/P-loop; other site 227882014202 ATP binding site [chemical binding]; other site 227882014203 Q-loop/lid; other site 227882014204 ABC transporter signature motif; other site 227882014205 Walker B; other site 227882014206 D-loop; other site 227882014207 H-loop/switch region; other site 227882014208 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 227882014209 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 227882014210 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 227882014211 classical (c) SDRs; Region: SDR_c; cd05233 227882014212 NAD(P) binding site [chemical binding]; other site 227882014213 active site 227882014214 PhoD-like phosphatase; Region: PhoD; pfam09423 227882014215 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 227882014216 putative active site [active] 227882014217 putative metal binding site [ion binding]; other site 227882014218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882014219 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 227882014220 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 227882014221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882014222 putative substrate translocation pore; other site 227882014223 Beta-lactamase; Region: Beta-lactamase; cl01009 227882014224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882014225 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882014226 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882014227 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 227882014228 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 227882014229 putative active site [active] 227882014230 catalytic site [active] 227882014231 putative metal binding site [ion binding]; other site 227882014232 oligomer interface [polypeptide binding]; other site 227882014233 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 227882014234 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 227882014235 Iron permease FTR1 family; Region: FTR1; cl00475 227882014236 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 227882014237 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 227882014238 Imelysin; Region: Peptidase_M75; cl09159 227882014239 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 227882014240 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 227882014241 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 227882014242 heme binding pocket [chemical binding]; other site 227882014243 heme ligand [chemical binding]; other site 227882014244 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 227882014245 methionine aminopeptidase; Reviewed; Region: PRK07281 227882014246 active site 227882014247 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 227882014248 catalytic site [active] 227882014249 Asp-box motif; other site 227882014250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882014251 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 227882014252 active site 227882014253 putative substrate binding region [chemical binding]; other site 227882014254 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 227882014255 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882014256 ABC-2 type transporter; Region: ABC2_membrane; cl11417 227882014257 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882014258 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 227882014259 Walker A/P-loop; other site 227882014260 ATP binding site [chemical binding]; other site 227882014261 Q-loop/lid; other site 227882014262 ABC transporter signature motif; other site 227882014263 Walker B; other site 227882014264 D-loop; other site 227882014265 H-loop/switch region; other site 227882014266 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 227882014267 active site 227882014268 oligomerization interface [polypeptide binding]; other site 227882014269 metal binding site [ion binding]; metal-binding site 227882014270 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 227882014271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882014272 putative substrate translocation pore; other site 227882014273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882014274 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882014275 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882014276 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 227882014277 putative catalytic site [active] 227882014278 putative metal binding site [ion binding]; other site 227882014279 putative phosphate binding site [ion binding]; other site 227882014280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882014281 putative substrate translocation pore; other site 227882014282 NAD synthetase; Provisional; Region: PRK13981 227882014283 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 227882014284 multimer interface [polypeptide binding]; other site 227882014285 active site 227882014286 catalytic triad [active] 227882014287 protein interface 1 [polypeptide binding]; other site 227882014288 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 227882014289 homodimer interface [polypeptide binding]; other site 227882014290 NAD binding pocket [chemical binding]; other site 227882014291 ATP binding pocket [chemical binding]; other site 227882014292 Mg binding site [ion binding]; other site 227882014293 active-site loop [active] 227882014294 Pro-kumamolisin, activation domain; Region: Pro-kuma_activ; cl07889 227882014295 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 227882014296 active site 227882014297 catalytic triad [active] 227882014298 calcium binding site [ion binding]; other site 227882014299 Domain of unknown function (DUF305); Region: DUF305; pfam03713 227882014300 Domain of unknown function (DUF305); Region: DUF305; pfam03713 227882014301 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 227882014302 Predicted transcriptional regulator [Transcription]; Region: COG1959 227882014303 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882014304 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 227882014305 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 227882014306 heme-binding site [chemical binding]; other site 227882014307 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 227882014308 FAD binding pocket [chemical binding]; other site 227882014309 FAD binding motif [chemical binding]; other site 227882014310 phosphate binding motif [ion binding]; other site 227882014311 beta-alpha-beta structure motif; other site 227882014312 NAD binding pocket [chemical binding]; other site 227882014313 Heme binding pocket [chemical binding]; other site 227882014314 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 227882014315 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 227882014316 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 227882014317 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 227882014318 active site 227882014319 Int/Topo IB signature motif; other site 227882014320 probable molybdenum cofactor biosynthesis protein A, archaeal; Region: moaA_archaeal; TIGR02668 227882014321 threonine dehydratase; Region: PLN02550 227882014322 Probable transposase; Region: OrfB_IS605; pfam01385 227882014323 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 227882014324 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882014325 ABC-2 type transporter; Region: ABC2_membrane; cl11417 227882014326 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882014327 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 227882014328 Walker A/P-loop; other site 227882014329 ATP binding site [chemical binding]; other site 227882014330 Q-loop/lid; other site 227882014331 ABC transporter signature motif; other site 227882014332 Walker B; other site 227882014333 D-loop; other site 227882014334 H-loop/switch region; other site 227882014335 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 227882014336 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 227882014337 active site 227882014338 metal binding site [ion binding]; metal-binding site 227882014339 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 227882014340 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 227882014341 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882014342 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 227882014343 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882014344 Sulfatase; Region: Sulfatase; cl10460 227882014345 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 227882014346 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 227882014347 metal binding triad; other site 227882014348 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 227882014349 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 227882014350 metal binding triad; other site 227882014351 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 227882014352 EamA-like transporter family; Region: EamA; cl01037 227882014353 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882014354 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 227882014355 putative dimerization interface [polypeptide binding]; other site 227882014356 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 227882014357 active site 227882014358 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882014359 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882014360 DNA binding site [nucleotide binding] 227882014361 domain linker motif; other site 227882014362 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 227882014363 putative dimerization interface [polypeptide binding]; other site 227882014364 putative ligand binding site [chemical binding]; other site 227882014365 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 227882014366 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882014367 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 227882014368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882014369 dimer interface [polypeptide binding]; other site 227882014370 conserved gate region; other site 227882014371 putative PBP binding loops; other site 227882014372 ABC-ATPase subunit interface; other site 227882014373 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 227882014374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882014375 dimer interface [polypeptide binding]; other site 227882014376 conserved gate region; other site 227882014377 putative PBP binding loops; other site 227882014378 ABC-ATPase subunit interface; other site 227882014379 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 227882014380 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 227882014381 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 227882014382 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 227882014383 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 227882014384 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 227882014385 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 227882014386 Bacterial pullanase-associated domain; Region: PUD; pfam03714 227882014387 Bacterial pullanase-associated domain; Region: PUD; pfam03714 227882014388 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 227882014389 Pullulanase domain N-terminus. Pullulanase (AKA dextrinase; alpha-dextrin endo-1,6-alpha glucosidase) is an enzyme with action similar to that of isoamylase; it cleaves 1,6-alpha-glucosidic linkages in pullulan, amylopectin, and glycogen, and in alpha-...; Region: Pullulanase_N_term; cd02860 227882014390 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 227882014391 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 227882014392 Response regulator receiver domain; Region: Response_reg; pfam00072 227882014393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882014394 active site 227882014395 phosphorylation site [posttranslational modification] 227882014396 intermolecular recognition site; other site 227882014397 dimerization interface [polypeptide binding]; other site 227882014398 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882014399 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 227882014400 putative substrate binding pocket [chemical binding]; other site 227882014401 trimer interface [polypeptide binding]; other site 227882014402 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882014403 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882014404 Tetratrico peptide repeat; Region: TPR_5; pfam12688 227882014405 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 227882014406 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 227882014407 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 227882014408 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 227882014409 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882014410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882014411 active site 227882014412 phosphorylation site [posttranslational modification] 227882014413 intermolecular recognition site; other site 227882014414 dimerization interface [polypeptide binding]; other site 227882014415 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882014416 DNA binding residues [nucleotide binding] 227882014417 dimerization interface [polypeptide binding]; other site 227882014418 Histidine kinase; Region: HisKA_3; pfam07730 227882014419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882014420 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 227882014421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882014422 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 227882014423 NAD(P) binding site [chemical binding]; other site 227882014424 active site 227882014425 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882014426 DNA binding site [nucleotide binding] 227882014427 glutamine synthetase; Region: PLN02284 227882014428 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 227882014429 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 227882014430 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 227882014431 catalytic residues [active] 227882014432 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882014433 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882014434 Phosphotransferase enzyme family; Region: APH; pfam01636 227882014435 active site 227882014436 substrate binding site [chemical binding]; other site 227882014437 ATP binding site [chemical binding]; other site 227882014438 Peptidase family M48; Region: Peptidase_M48; cl12018 227882014439 glutamine synthetase, type I; Region: GlnA; TIGR00653 227882014440 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 227882014441 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 227882014442 RDD family; Region: RDD; cl00746 227882014443 lipoyl synthase; Provisional; Region: PRK05481 227882014444 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 227882014445 FeS/SAM binding site; other site 227882014446 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 227882014447 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 227882014448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882014449 TIGR01777 family protein; Region: yfcH 227882014450 NAD(P) binding site [chemical binding]; other site 227882014451 active site 227882014452 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882014453 putative acetyltransferase YhhY; Provisional; Region: PRK10140 227882014454 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 227882014455 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 227882014456 amidase catalytic site [active] 227882014457 Zn binding residues [ion binding]; other site 227882014458 substrate binding site [chemical binding]; other site 227882014459 Predicted transcriptional regulator [Transcription]; Region: COG2378 227882014460 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882014461 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 227882014462 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 227882014463 dimer interface [polypeptide binding]; other site 227882014464 TPP-binding site [chemical binding]; other site 227882014465 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 227882014466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882014467 DNA-binding site [nucleotide binding]; DNA binding site 227882014468 FCD domain; Region: FCD; cl11656 227882014469 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 227882014470 E3 interaction surface; other site 227882014471 lipoyl attachment site [posttranslational modification]; other site 227882014472 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 227882014473 E3 interaction surface; other site 227882014474 lipoyl attachment site [posttranslational modification]; other site 227882014475 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 227882014476 e3 binding domain; Region: E3_binding; pfam02817 227882014477 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 227882014478 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 227882014479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882014480 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 227882014481 multifunctional aminopeptidase A; Provisional; Region: PRK00913 227882014482 Cytosol aminopeptidase family, N-terminal domain; Region: Peptidase_M17_N; pfam02789 227882014483 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 227882014484 interface (dimer of trimers) [polypeptide binding]; other site 227882014485 Substrate-binding/catalytic site; other site 227882014486 Zn-binding sites [ion binding]; other site 227882014487 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 227882014488 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 227882014489 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 227882014490 putative dimer interface [polypeptide binding]; other site 227882014491 active site pocket [active] 227882014492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882014493 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 227882014494 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544 227882014495 homotrimer interface [polypeptide binding]; other site 227882014496 Walker A motif; other site 227882014497 GTP binding site [chemical binding]; other site 227882014498 Walker B motif; other site 227882014499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882014500 S-adenosylmethionine binding site [chemical binding]; other site 227882014501 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 227882014502 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 227882014503 Histidine kinase; Region: HisKA_3; pfam07730 227882014504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882014505 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882014506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882014507 active site 227882014508 phosphorylation site [posttranslational modification] 227882014509 intermolecular recognition site; other site 227882014510 dimerization interface [polypeptide binding]; other site 227882014511 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882014512 DNA binding residues [nucleotide binding] 227882014513 dimerization interface [polypeptide binding]; other site 227882014514 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 227882014515 Quinolinate synthetase A protein; Region: NadA; cl00420 227882014516 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 227882014517 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 227882014518 substrate binding site [chemical binding]; other site 227882014519 ATP binding site [chemical binding]; other site 227882014520 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 227882014521 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882014522 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 227882014523 catalytic residue [active] 227882014524 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 227882014525 CPxP motif; other site 227882014526 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 227882014527 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 227882014528 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 227882014529 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 227882014530 D-pathway; other site 227882014531 Putative ubiquinol binding site [chemical binding]; other site 227882014532 Low-spin heme (heme b) binding site [chemical binding]; other site 227882014533 Putative water exit pathway; other site 227882014534 Binuclear center (heme o3/CuB) [ion binding]; other site 227882014535 K-pathway; other site 227882014536 Putative proton exit pathway; other site 227882014537 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 227882014538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 227882014539 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 227882014540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882014541 active site 227882014542 phosphorylation site [posttranslational modification] 227882014543 intermolecular recognition site; other site 227882014544 dimerization interface [polypeptide binding]; other site 227882014545 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 227882014546 Subunit I/III interface [polypeptide binding]; other site 227882014547 Cytochrome c; Region: Cytochrom_C; cl11414 227882014548 Cytochrome c; Region: Cytochrom_C; cl11414 227882014549 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 227882014550 iron-sulfur cluster [ion binding]; other site 227882014551 [2Fe-2S] cluster binding site [ion binding]; other site 227882014552 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 227882014553 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 227882014554 Qi binding site; other site 227882014555 intrachain domain interface; other site 227882014556 interchain domain interface [polypeptide binding]; other site 227882014557 heme bH binding site [chemical binding]; other site 227882014558 heme bL binding site [chemical binding]; other site 227882014559 Qo binding site; other site 227882014560 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 227882014561 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 227882014562 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 227882014563 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 227882014564 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882014565 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 227882014566 catalytic residue [active] 227882014567 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882014568 Rhomboid family; Region: Rhomboid; cl11446 227882014569 Myosin tail; Region: Myosin_tail_1; pfam01576 227882014570 YacP-like NYN domain; Region: NYN_YacP; cl01491 227882014571 chromosome segregation protein; Provisional; Region: PRK03918 227882014572 NlpC/P60 family; Region: NLPC_P60; cl11438 227882014573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 227882014574 NlpC/P60 family; Region: NLPC_P60; cl11438 227882014575 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 227882014576 MatE; Region: MatE; cl10513 227882014577 MatE; Region: MatE; cl10513 227882014578 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 227882014579 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 227882014580 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 227882014581 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 227882014582 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 227882014583 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882014584 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882014585 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 227882014586 active site 227882014587 metal binding site [ion binding]; metal-binding site 227882014588 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 227882014589 putative hydrophobic ligand binding site [chemical binding]; other site 227882014590 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 227882014591 dimerization interface [polypeptide binding]; other site 227882014592 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 227882014593 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882014594 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 227882014595 putative catalytic site [active] 227882014596 putative metal binding site [ion binding]; other site 227882014597 putative phosphate binding site [ion binding]; other site 227882014598 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 227882014599 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882014600 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882014601 DNA binding residues [nucleotide binding] 227882014602 Esterase/lipase [General function prediction only]; Region: COG1647 227882014603 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882014604 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 227882014605 putative acyl-acceptor binding pocket; other site 227882014606 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 227882014607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882014608 ATP binding site [chemical binding]; other site 227882014609 Mg2+ binding site [ion binding]; other site 227882014610 G-X-G motif; other site 227882014611 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882014612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882014613 active site 227882014614 phosphorylation site [posttranslational modification] 227882014615 intermolecular recognition site; other site 227882014616 dimerization interface [polypeptide binding]; other site 227882014617 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882014618 DNA binding residues [nucleotide binding] 227882014619 dimerization interface [polypeptide binding]; other site 227882014620 6-phosphofructokinase; Provisional; Region: PRK03202 227882014621 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cd00363 227882014622 active site 227882014623 ADP/pyrophosphate binding site [chemical binding]; other site 227882014624 dimerization interface [polypeptide binding]; other site 227882014625 allosteric effector site; other site 227882014626 fructose-1,6-bisphosphate binding site; other site 227882014627 chorismate binding enzyme; Region: Chorismate_bind; cl10555 227882014628 Glutamine amidotransferase class-I; Region: GATase; pfam00117 227882014629 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 227882014630 glutamine binding [chemical binding]; other site 227882014631 catalytic triad [active] 227882014632 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins...; Region: GH25_BacA-like; cd06418 227882014633 active site 227882014634 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 227882014635 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 227882014636 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 227882014637 Ferritin-like domain; Region: Ferritin; pfam00210 227882014638 heme binding site [chemical binding]; other site 227882014639 ferroxidase pore; other site 227882014640 ferroxidase diiron center [ion binding]; other site 227882014641 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 227882014642 Moco binding site; other site 227882014643 metal coordination site [ion binding]; other site 227882014644 AP endonuclease family 2; Region: AP2Ec; smart00518 227882014645 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cd00019 227882014646 AP (apurinic/apyrimidinic) site pocket; other site 227882014647 DNA interaction; other site 227882014648 Metal-binding active site; metal-binding site 227882014649 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882014650 Catalytic domain of Protein Kinases; Region: PKc; cd00180 227882014651 active site 227882014652 ATP binding site [chemical binding]; other site 227882014653 substrate binding site [chemical binding]; other site 227882014654 activation loop (A-loop); other site 227882014655 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 227882014656 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 227882014657 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 227882014658 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 227882014659 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 227882014660 ThiS interaction site; other site 227882014661 putative active site [active] 227882014662 tetramer interface [polypeptide binding]; other site 227882014663 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 227882014664 thiS-thiF/thiG interaction site; other site 227882014665 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 227882014666 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 227882014667 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 227882014668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882014669 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 227882014670 thiamine phosphate binding site [chemical binding]; other site 227882014671 active site 227882014672 pyrophosphate binding site [ion binding]; other site 227882014673 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 227882014674 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 227882014675 FAD binding site [chemical binding]; other site 227882014676 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 227882014677 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882014678 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882014679 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882014680 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 227882014681 ABC-2 type transporter; Region: ABC2_membrane; cl11417 227882014682 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882014683 Walker A/P-loop; other site 227882014684 ATP binding site [chemical binding]; other site 227882014685 Q-loop/lid; other site 227882014686 ABC transporter signature motif; other site 227882014687 Walker B; other site 227882014688 D-loop; other site 227882014689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882014690 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 227882014691 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 227882014692 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 227882014693 Protein of unknown function DUF58; Region: DUF58; pfam01882 227882014694 MoxR-like ATPases [General function prediction only]; Region: COG0714 227882014695 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882014696 Walker A motif; other site 227882014697 ATP binding site [chemical binding]; other site 227882014698 Walker B motif; other site 227882014699 arginine finger; other site 227882014700 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 227882014701 active site clefts [active] 227882014702 zinc binding site [ion binding]; other site 227882014703 dimer interface [polypeptide binding]; other site 227882014704 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 227882014705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882014706 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 227882014707 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 227882014708 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 227882014709 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 227882014710 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 227882014711 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 227882014712 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 227882014713 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 227882014714 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 227882014715 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 227882014716 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 227882014717 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 227882014718 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 227882014719 Mg++ binding site [ion binding]; other site 227882014720 putative catalytic motif [active] 227882014721 putative substrate binding site [chemical binding]; other site 227882014722 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 227882014723 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 227882014724 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 227882014725 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 227882014726 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 227882014727 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 227882014728 active site 227882014729 homodimer interface [polypeptide binding]; other site 227882014730 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 227882014731 Cell division protein FtsQ; Region: FtsQ; pfam03799 227882014732 cell division protein FtsZ; Validated; Region: PRK09330 227882014733 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 227882014734 nucleotide binding site [chemical binding]; other site 227882014735 SulA interaction site; other site 227882014736 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 227882014737 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 227882014738 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 227882014739 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 227882014740 catalytic residue [active] 227882014741 Protein of unknown function (DUF552); Region: DUF552; cl00775 227882014742 YGGT family; Region: YGGT; cl00508 227882014743 DivIVA domain; Region: DivI1A_domain; TIGR03544 227882014744 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 227882014745 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 227882014746 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 227882014747 HIGH motif; other site 227882014748 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 227882014749 active site 227882014750 KMSKS motif; other site 227882014751 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 227882014752 tRNA binding surface [nucleotide binding]; other site 227882014753 anticodon binding site; other site 227882014754 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 227882014755 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 227882014756 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 227882014757 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 227882014758 RNA binding surface [nucleotide binding]; other site 227882014759 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 227882014760 active site 227882014761 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 227882014762 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 227882014763 classical (c) SDRs; Region: SDR_c; cd05233 227882014764 NAD(P) binding site [chemical binding]; other site 227882014765 active site 227882014766 Mechanosensitive ion channel; Region: MS_channel; pfam00924 227882014767 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 227882014768 PhoD-like phosphatase; Region: PhoD; pfam09423 227882014769 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 227882014770 putative active site [active] 227882014771 putative metal binding site [ion binding]; other site 227882014772 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 227882014773 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 227882014774 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 227882014775 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 227882014776 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 227882014777 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 227882014778 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 227882014779 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 227882014780 generic binding surface II; other site 227882014781 generic binding surface I; other site 227882014782 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 227882014783 putative metal binding site [ion binding]; other site 227882014784 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882014785 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 227882014786 Walker A/P-loop; other site 227882014787 ATP binding site [chemical binding]; other site 227882014788 Q-loop/lid; other site 227882014789 ABC transporter signature motif; other site 227882014790 Walker B; other site 227882014791 D-loop; other site 227882014792 H-loop/switch region; other site 227882014793 ABC-2 type transporter; Region: ABC2_membrane; cl11417 227882014794 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS); Region: YbaK_deacylase; cd00002 227882014795 putative deacylase active site [active] 227882014796 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 227882014797 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 227882014798 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 227882014799 NAD binding site [chemical binding]; other site 227882014800 dimerization interface [polypeptide binding]; other site 227882014801 product binding site; other site 227882014802 substrate binding site [chemical binding]; other site 227882014803 zinc binding site [ion binding]; other site 227882014804 catalytic residues [active] 227882014805 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 227882014806 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 227882014807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882014808 homodimer interface [polypeptide binding]; other site 227882014809 catalytic residue [active] 227882014810 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 227882014811 putative active site pocket [active] 227882014812 4-fold oligomerization interface [polypeptide binding]; other site 227882014813 metal binding residues [ion binding]; metal-binding site 227882014814 3-fold/trimer interface [polypeptide binding]; other site 227882014815 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 227882014816 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 227882014817 putative active site [active] 227882014818 oxyanion strand; other site 227882014819 catalytic triad [active] 227882014820 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 227882014821 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 227882014822 catalytic residues [active] 227882014823 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 227882014824 homotrimer interaction site [polypeptide binding]; other site 227882014825 putative active site [active] 227882014826 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 227882014827 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 227882014828 substrate binding site [chemical binding]; other site 227882014829 glutamase interaction surface [polypeptide binding]; other site 227882014830 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 227882014831 dimerization interface [polypeptide binding]; other site 227882014832 putative DNA binding site [nucleotide binding]; other site 227882014833 putative Zn2+ binding site [ion binding]; other site 227882014834 H+ Antiporter protein; Region: 2A0121; TIGR00900 227882014835 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882014836 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 227882014837 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 227882014838 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 227882014839 Walker A/P-loop; other site 227882014840 ATP binding site [chemical binding]; other site 227882014841 Q-loop/lid; other site 227882014842 ABC transporter signature motif; other site 227882014843 Walker B; other site 227882014844 D-loop; other site 227882014845 H-loop/switch region; other site 227882014846 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 227882014847 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 227882014848 Walker A/P-loop; other site 227882014849 ATP binding site [chemical binding]; other site 227882014850 Q-loop/lid; other site 227882014851 ABC transporter signature motif; other site 227882014852 Walker B; other site 227882014853 D-loop; other site 227882014854 H-loop/switch region; other site 227882014855 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 227882014856 TM-ABC transporter signature motif; other site 227882014857 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 227882014858 TM-ABC transporter signature motif; other site 227882014859 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 227882014860 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 227882014861 TIGR03085 family protein; Region: TIGR03085 227882014862 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 227882014863 anthranilate synthase component I; Provisional; Region: PRK13571 227882014864 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 227882014865 chorismate binding enzyme; Region: Chorismate_bind; cl10555 227882014866 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; cl09759 227882014867 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 227882014868 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 227882014869 active site 227882014870 ribulose/triose binding site [chemical binding]; other site 227882014871 phosphate binding site [ion binding]; other site 227882014872 substrate (anthranilate) binding pocket [chemical binding]; other site 227882014873 product (indole) binding pocket [chemical binding]; other site 227882014874 tryptophan synthase, beta chain; Region: PLN02618 227882014875 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 227882014876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882014877 catalytic residue [active] 227882014878 tryptophan synthase; Region: PLN02591 227882014879 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 227882014880 substrate binding site [chemical binding]; other site 227882014881 active site 227882014882 catalytic residues [active] 227882014883 heterodimer interface [polypeptide binding]; other site 227882014884 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 227882014885 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 227882014886 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 227882014887 CoA-transferase family III; Region: CoA_transf_3; cl00778 227882014888 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 227882014889 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 227882014890 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 227882014891 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 227882014892 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 227882014893 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The N-...; Region: GltS; cd00713 227882014894 active site 227882014895 dimer interface [polypeptide binding]; other site 227882014896 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 227882014897 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 227882014898 active site 227882014899 FMN binding site [chemical binding]; other site 227882014900 substrate binding site [chemical binding]; other site 227882014901 3Fe-4S cluster binding site [ion binding]; other site 227882014902 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 227882014903 domain interface; other site 227882014904 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 227882014905 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882014906 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin...; Region: chitosanase_glyco_hydro_46; cd00978 227882014907 chitosan binding site [chemical binding]; other site 227882014908 catalytic residues [active] 227882014909 Rhomboid family; Region: Rhomboid; cl11446 227882014910 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 227882014911 metal ion-dependent adhesion site (MIDAS); other site 227882014912 HutD; Region: HutD; cl01532 227882014913 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 227882014914 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882014915 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 227882014916 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882014917 active site 227882014918 short chain dehydrogenase; Provisional; Region: PRK07831 227882014919 classical (c) SDRs; Region: SDR_c; cd05233 227882014920 NAD(P) binding site [chemical binding]; other site 227882014921 active site 227882014922 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 227882014923 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882014924 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 227882014925 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 227882014926 dimer interface [polypeptide binding]; other site 227882014927 active site 227882014928 Nitronate monooxygenase; Region: NMO; pfam03060 227882014929 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 227882014930 FMN binding site [chemical binding]; other site 227882014931 substrate binding site [chemical binding]; other site 227882014932 putative catalytic residue [active] 227882014933 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 227882014934 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 227882014935 enoyl-CoA hydratase; Provisional; Region: PRK07938 227882014936 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 227882014937 substrate binding site [chemical binding]; other site 227882014938 oxyanion hole (OAH) forming residues; other site 227882014939 trimer interface [polypeptide binding]; other site 227882014940 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882014941 NAD(P) binding site [chemical binding]; other site 227882014942 active site 227882014943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882014944 NAD(P) binding site [chemical binding]; other site 227882014945 active site 227882014946 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 227882014947 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 227882014948 putative lyase; Provisional; Region: PRK09687 227882014949 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cd00190 227882014950 cleavage site 227882014951 active site 227882014952 substrate binding sites [chemical binding]; other site 227882014953 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882014954 Chorismate mutase type II; Region: CM_2; cl00693 227882014955 Response regulator receiver domain; Region: Response_reg; pfam00072 227882014956 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882014957 active site 227882014958 phosphorylation site [posttranslational modification] 227882014959 intermolecular recognition site; other site 227882014960 dimerization interface [polypeptide binding]; other site 227882014961 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 227882014962 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 227882014963 Zn binding site [ion binding]; other site 227882014964 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 227882014965 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882014966 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 227882014967 catalytic residue [active] 227882014968 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 227882014969 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 227882014970 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 227882014971 active site 227882014972 metal binding site [ion binding]; metal-binding site 227882014973 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 227882014974 Protein of unknown function (DUF541); Region: SIMPL; cl01077 227882014975 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 227882014976 pyruvate kinase; Provisional; Region: PRK06247 227882014977 domain interfaces; other site 227882014978 active site 227882014979 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 227882014980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882014981 active site 227882014982 phosphorylation site [posttranslational modification] 227882014983 intermolecular recognition site; other site 227882014984 dimerization interface [polypeptide binding]; other site 227882014985 ANTAR domain; Region: ANTAR; cl04297 227882014986 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 227882014987 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 227882014988 Walker A/P-loop; other site 227882014989 ATP binding site [chemical binding]; other site 227882014990 Q-loop/lid; other site 227882014991 ABC transporter signature motif; other site 227882014992 Walker B; other site 227882014993 D-loop; other site 227882014994 H-loop/switch region; other site 227882014995 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 227882014996 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 227882014997 Walker A/P-loop; other site 227882014998 ATP binding site [chemical binding]; other site 227882014999 Q-loop/lid; other site 227882015000 ABC transporter signature motif; other site 227882015001 Walker B; other site 227882015002 D-loop; other site 227882015003 H-loop/switch region; other site 227882015004 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 227882015005 TM-ABC transporter signature motif; other site 227882015006 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 227882015007 TM-ABC transporter signature motif; other site 227882015008 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 227882015009 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 227882015010 dimerization interface [polypeptide binding]; other site 227882015011 ligand binding site [chemical binding]; other site 227882015012 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 227882015013 CoenzymeA binding site [chemical binding]; other site 227882015014 subunit interaction site [polypeptide binding]; other site 227882015015 PHB binding site; other site 227882015016 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 227882015017 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 227882015018 putative molybdopterin cofactor binding site [chemical binding]; other site 227882015019 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT)...; Region: MopB_CT_ydeP; cd02787 227882015020 putative molybdopterin cofactor binding site; other site 227882015021 DNA polymerase I; Provisional; Region: PRK05755 227882015022 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 227882015023 active site 227882015024 metal binding site 1 [ion binding]; metal-binding site 227882015025 putative 5' ssDNA interaction site; other site 227882015026 metal binding site 3; metal-binding site 227882015027 metal binding site 2 [ion binding]; metal-binding site 227882015028 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 227882015029 putative DNA binding site [nucleotide binding]; other site 227882015030 putative metal binding site [ion binding]; other site 227882015031 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 227882015032 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 227882015033 active site 227882015034 DNA binding site [nucleotide binding] 227882015035 catalytic site [active] 227882015036 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 227882015037 N-acetyl-D-glucosamine binding site [chemical binding]; other site 227882015038 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 227882015039 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 227882015040 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882015041 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 227882015042 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 227882015043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882015044 S-adenosylmethionine binding site [chemical binding]; other site 227882015045 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 227882015046 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 227882015047 RNA binding site [nucleotide binding]; other site 227882015048 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 227882015049 RNA binding site [nucleotide binding]; other site 227882015050 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 227882015051 RNA binding site [nucleotide binding]; other site 227882015052 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 227882015053 RNA binding site [nucleotide binding]; other site 227882015054 PAC2 family; Region: PAC2; cl00847 227882015055 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 227882015056 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 227882015057 CoA-binding site [chemical binding]; other site 227882015058 ATP-binding [chemical binding]; other site 227882015059 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 227882015060 binding surface 227882015061 TPR motif; other site 227882015062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882015063 S-adenosylmethionine binding site [chemical binding]; other site 227882015064 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 227882015065 RNA binding surface [nucleotide binding]; other site 227882015066 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 227882015067 Fe-S cluster binding site [ion binding]; other site 227882015068 DNA binding site [nucleotide binding] 227882015069 active site 227882015070 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 227882015071 homotrimer interaction site [polypeptide binding]; other site 227882015072 putative active site [active] 227882015073 Putative amidase domain; Region: Amidase_6; pfam12671 227882015074 Cytochrome P450; Region: p450; cl12078 227882015075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882015076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882015077 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882015078 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 227882015079 Leucine carboxyl methyltransferase; Region: LCM; cl01306 227882015080 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 227882015081 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882015082 DNA-binding site [nucleotide binding]; DNA binding site 227882015083 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 227882015084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882015085 homodimer interface [polypeptide binding]; other site 227882015086 catalytic residue [active] 227882015087 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 227882015088 Uncharacterized conserved protein [Function unknown]; Region: COG2128 227882015089 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 227882015090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882015091 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 227882015092 Uncharacterized conserved protein (DUF2293); Region: DUF2293; cl02373 227882015093 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882015094 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 227882015095 FOG: CBS domain [General function prediction only]; Region: COG0517 227882015096 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_9; cd04622 227882015097 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 227882015098 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 227882015099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882015100 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 227882015101 substrate binding site [chemical binding]; other site 227882015102 ATP binding site [chemical binding]; other site 227882015103 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 227882015104 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 227882015105 dimer interface [polypeptide binding]; other site 227882015106 metal binding site [ion binding]; metal-binding site 227882015107 Cupin domain; Region: Cupin_2; cl09118 227882015108 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 227882015109 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 227882015110 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 227882015111 DNA binding site [nucleotide binding] 227882015112 active site 227882015113 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 227882015114 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 227882015115 active site 227882015116 catalytic site [active] 227882015117 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 227882015118 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 227882015119 excinuclease ABC subunit B; Provisional; Region: PRK05298 227882015120 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882015121 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 227882015122 nucleotide binding region [chemical binding]; other site 227882015123 ATP-binding site [chemical binding]; other site 227882015124 Ultra-violet resistance protein B; Region: UvrB; pfam12344 227882015125 UvrB/uvrC motif; Region: UVR; pfam02151 227882015126 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 227882015127 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 227882015128 putative metal binding site [ion binding]; other site 227882015129 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 227882015130 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 227882015131 Integral membrane protein TerC family; Region: TerC; cl10468 227882015132 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 227882015133 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 227882015134 metabolite-proton symporter; Region: 2A0106; TIGR00883 227882015135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882015136 putative substrate translocation pore; other site 227882015137 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 227882015138 putative dimer interface [polypeptide binding]; other site 227882015139 catalytic triad [active] 227882015140 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 227882015141 trimer interface [polypeptide binding]; other site 227882015142 active site 227882015143 dimer interface [polypeptide binding]; other site 227882015144 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 227882015145 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882015146 Walker A/P-loop; other site 227882015147 ATP binding site [chemical binding]; other site 227882015148 Q-loop/lid; other site 227882015149 ABC transporter signature motif; other site 227882015150 Walker B; other site 227882015151 D-loop; other site 227882015152 H-loop/switch region; other site 227882015153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882015154 dimer interface [polypeptide binding]; other site 227882015155 conserved gate region; other site 227882015156 putative PBP binding loops; other site 227882015157 ABC-ATPase subunit interface; other site 227882015158 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 227882015159 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 227882015160 substrate binding pocket [chemical binding]; other site 227882015161 membrane-bound complex binding site; other site 227882015162 hinge residues; other site 227882015163 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 227882015164 mycothiol-dependent maleylpyruvate isomerase; Reviewed; Region: PRK09583 227882015165 DinB superfamily; Region: DinB_2; cl00986 227882015166 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 227882015167 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 227882015168 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 227882015169 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 227882015170 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 227882015171 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 227882015172 putative substrate binding site [chemical binding]; other site 227882015173 putative ATP binding site [chemical binding]; other site 227882015174 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882015175 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882015176 DNA binding site [nucleotide binding] 227882015177 domain linker motif; other site 227882015178 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 227882015179 ligand binding site [chemical binding]; other site 227882015180 dimerization interface [polypeptide binding]; other site 227882015181 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 227882015182 iron-sulfur cluster [ion binding]; other site 227882015183 [2Fe-2S] cluster binding site [ion binding]; other site 227882015184 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 227882015185 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 227882015186 GIY-YIG motif/motif A; other site 227882015187 active site 227882015188 catalytic site [active] 227882015189 putative DNA binding site [nucleotide binding]; other site 227882015190 metal binding site [ion binding]; metal-binding site 227882015191 UvrB/uvrC motif; Region: UVR; pfam02151 227882015192 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 227882015193 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 227882015194 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882015195 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 227882015196 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 227882015197 putative substrate binding pocket [chemical binding]; other site 227882015198 dimer interface [polypeptide binding]; other site 227882015199 phosphate binding site [ion binding]; other site 227882015200 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 227882015201 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 227882015202 Peptidase M14-like domain of carboxypeptidase (CP) T (CPT), CPT belongs to the M14 family of metallocarboxypeptidases (MCPs). The M14 family are zinc-binding CPs which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a...; Region: M14_CPT; cd03859 227882015203 putative active site [active] 227882015204 Zn-binding site [ion binding]; other site 227882015205 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 227882015206 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 227882015207 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 227882015208 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 227882015209 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 227882015210 substrate binding site [chemical binding]; other site 227882015211 hinge regions; other site 227882015212 ADP binding site [chemical binding]; other site 227882015213 catalytic site [active] 227882015214 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 227882015215 substrate binding site [chemical binding]; other site 227882015216 dimer interface [polypeptide binding]; other site 227882015217 catalytic triad [active] 227882015218 H+ Antiporter protein; Region: 2A0121; TIGR00900 227882015219 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882015220 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 227882015221 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 227882015222 active site 227882015223 dimer interface [polypeptide binding]; other site 227882015224 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 227882015225 dimer interface [polypeptide binding]; other site 227882015226 active site 227882015227 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 227882015228 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 227882015229 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 227882015230 Walker A/P-loop; other site 227882015231 ATP binding site [chemical binding]; other site 227882015232 Q-loop/lid; other site 227882015233 ABC transporter signature motif; other site 227882015234 Walker B; other site 227882015235 D-loop; other site 227882015236 H-loop/switch region; other site 227882015237 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882015238 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 227882015239 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882015240 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 227882015241 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 227882015242 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882015243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 227882015244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882015245 putative PBP binding loops; other site 227882015246 ABC-ATPase subunit interface; other site 227882015247 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 227882015248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882015249 dimer interface [polypeptide binding]; other site 227882015250 conserved gate region; other site 227882015251 putative PBP binding loops; other site 227882015252 ABC-ATPase subunit interface; other site 227882015253 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 227882015254 putative active site [active] 227882015255 opcA protein; Region: OpcA; TIGR00534 227882015256 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 227882015257 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 227882015258 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 227882015259 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 227882015260 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 227882015261 putative active site [active] 227882015262 transaldolase; Provisional; Region: PRK03903 227882015263 catalytic residue [active] 227882015264 transketolase; Reviewed; Region: PRK05899 227882015265 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 227882015266 TPP-binding site [chemical binding]; other site 227882015267 dimer interface [polypeptide binding]; other site 227882015268 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 227882015269 PYR/PP interface [polypeptide binding]; other site 227882015270 dimer interface [polypeptide binding]; other site 227882015271 TPP binding site [chemical binding]; other site 227882015272 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 227882015273 UbiA prenyltransferase family; Region: UbiA; cl00337 227882015274 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 227882015275 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 227882015276 ABC-2 type transporter; Region: ABC2_membrane; cl11417 227882015277 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 227882015278 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 227882015279 Walker A/P-loop; other site 227882015280 ATP binding site [chemical binding]; other site 227882015281 Q-loop/lid; other site 227882015282 ABC transporter signature motif; other site 227882015283 Walker B; other site 227882015284 D-loop; other site 227882015285 H-loop/switch region; other site 227882015286 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; cl01051 227882015287 Predicted transcriptional regulator [Transcription]; Region: COG2345 227882015288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882015289 FeS assembly protein SufB; Region: sufB; TIGR01980 227882015290 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 227882015291 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 227882015292 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 227882015293 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise...; Region: Rieske_RO_ferredoxin; cd03528 227882015294 [2Fe-2S] cluster binding site [ion binding]; other site 227882015295 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 227882015296 FeS assembly ATPase SufC; Region: sufC; TIGR01978 227882015297 Walker A/P-loop; other site 227882015298 ATP binding site [chemical binding]; other site 227882015299 Q-loop/lid; other site 227882015300 ABC transporter signature motif; other site 227882015301 Walker B; other site 227882015302 D-loop; other site 227882015303 H-loop/switch region; other site 227882015304 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 227882015305 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 227882015306 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 227882015307 catalytic residue [active] 227882015308 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 227882015309 trimerization site [polypeptide binding]; other site 227882015310 active site 227882015311 Domain of unknown function DUF59; Region: DUF59; cl00941 227882015312 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 227882015313 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 227882015314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 227882015315 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 227882015316 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882015317 DNA binding residues [nucleotide binding] 227882015318 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 227882015319 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 227882015320 putative trimer interface [polypeptide binding]; other site 227882015321 putative CoA binding site [chemical binding]; other site 227882015322 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 227882015323 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882015324 DNA binding residues [nucleotide binding] 227882015325 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 227882015326 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 227882015327 dimer interface [polypeptide binding]; other site 227882015328 active site 227882015329 catalytic residue [active] 227882015330 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 227882015331 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 227882015332 generic binding surface I; other site 227882015333 generic binding surface II; other site 227882015334 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 227882015335 putative catalytic site [active] 227882015336 putative metal binding site [ion binding]; other site 227882015337 putative phosphate binding site [ion binding]; other site 227882015338 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 227882015339 TROVE domain; Region: TROVE; pfam05731 227882015340 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 227882015341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882015342 putative substrate translocation pore; other site 227882015343 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 227882015344 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882015345 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 227882015346 putative metal binding site [ion binding]; other site 227882015347 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 227882015348 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 227882015349 putative metal binding site [ion binding]; other site 227882015350 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 227882015351 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 227882015352 putative NAD(P) binding site [chemical binding]; other site 227882015353 catalytic Zn binding site [ion binding]; other site 227882015354 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 227882015355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882015356 dimer interface [polypeptide binding]; other site 227882015357 conserved gate region; other site 227882015358 putative PBP binding loops; other site 227882015359 ABC-ATPase subunit interface; other site 227882015360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882015361 dimer interface [polypeptide binding]; other site 227882015362 ABC-ATPase subunit interface; other site 227882015363 putative PBP binding loops; other site 227882015364 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 227882015365 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882015366 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 227882015367 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882015368 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 227882015369 extended (e) SDRs; Region: SDR_e; cd08946 227882015370 NAD(P) binding site [chemical binding]; other site 227882015371 active site 227882015372 substrate binding site [chemical binding]; other site 227882015373 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 227882015374 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 227882015375 catalytic residue [active] 227882015376 H+ Antiporter protein; Region: 2A0121; TIGR00900 227882015377 TIGR03086 family protein; Region: TIGR03086 227882015378 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 227882015379 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882015380 DNA-binding site [nucleotide binding]; DNA binding site 227882015381 FCD domain; Region: FCD; cl11656 227882015382 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 227882015383 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 227882015384 inhibitor site; inhibition site 227882015385 active site 227882015386 dimer interface [polypeptide binding]; other site 227882015387 catalytic residue [active] 227882015388 dihydroxy-acid dehydratase; Provisional; Region: PRK13017 227882015389 Dehydratase family; Region: ILVD_EDD; cl00340 227882015390 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 227882015391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882015392 putative PBP binding loops; other site 227882015393 dimer interface [polypeptide binding]; other site 227882015394 ABC-ATPase subunit interface; other site 227882015395 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 227882015396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882015397 dimer interface [polypeptide binding]; other site 227882015398 conserved gate region; other site 227882015399 putative PBP binding loops; other site 227882015400 ABC-ATPase subunit interface; other site 227882015401 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 227882015402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882015403 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 227882015404 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 227882015405 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 227882015406 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882015407 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 227882015408 active site 227882015409 catalytic triad [active] 227882015410 Pectate lyase; Region: Pec_lyase_C; cl01593 227882015411 Pectinesterase; Region: Pectinesterase; cl01911 227882015412 Pectinesterase; Region: Pectinesterase; cl01911 227882015413 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882015414 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 227882015415 active site 227882015416 Putative glycoside hydrolase; Region: Glyco_hydro_44; pfam12891 227882015417 Glycosyl hydrolases family 43; Region: Glyco_hydro_43; pfam04616 227882015418 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 227882015419 putative substrate binding site [chemical binding]; other site 227882015420 active site 227882015421 Pectate lyase; Region: Pectate_lyase; pfam03211 227882015422 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 227882015423 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882015424 DNA binding residues [nucleotide binding] 227882015425 Sulfate transporter family; Region: Sulfate_transp; cl00967 227882015426 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 227882015427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882015428 Transcriptional regulator [Transcription]; Region: IclR; COG1414 227882015429 Bacterial transcriptional regulator; Region: IclR; pfam01614 227882015430 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 227882015431 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 227882015432 dimer interface [polypeptide binding]; other site 227882015433 NADP binding site [chemical binding]; other site 227882015434 catalytic residues [active] 227882015435 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 227882015436 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882015437 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 227882015438 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 227882015439 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 227882015440 conserved cys residue [active] 227882015441 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 227882015442 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 227882015443 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 227882015444 catalytic residues [active] 227882015445 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 227882015446 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882015447 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 227882015448 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 227882015449 Cupin domain; Region: Cupin_2; cl09118 227882015450 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 227882015451 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 227882015452 inhibitor-cofactor binding pocket; inhibition site 227882015453 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882015454 catalytic residue [active] 227882015455 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 227882015456 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 227882015457 Coenzyme A binding pocket [chemical binding]; other site 227882015458 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882015459 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 227882015460 catalytic residue [active] 227882015461 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 227882015462 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 227882015463 substrate binding pocket [chemical binding]; other site 227882015464 membrane-bound complex binding site; other site 227882015465 hinge residues; other site 227882015466 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 227882015467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882015468 dimer interface [polypeptide binding]; other site 227882015469 conserved gate region; other site 227882015470 putative PBP binding loops; other site 227882015471 ABC-ATPase subunit interface; other site 227882015472 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 227882015473 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 227882015474 Walker A/P-loop; other site 227882015475 ATP binding site [chemical binding]; other site 227882015476 Q-loop/lid; other site 227882015477 ABC transporter signature motif; other site 227882015478 Walker B; other site 227882015479 D-loop; other site 227882015480 H-loop/switch region; other site 227882015481 dihydropyrimidinase; Provisional; Region: PRK13404 227882015482 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 227882015483 active site 227882015484 hypothetical protein; Provisional; Region: PRK07908 227882015485 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 227882015486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882015487 homodimer interface [polypeptide binding]; other site 227882015488 catalytic residue [active] 227882015489 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 227882015490 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_N; cd03416 227882015491 putative active site [active] 227882015492 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a...; Region: CbiX_SirB_C; cd03414 227882015493 putative active site [active] 227882015494 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 227882015495 Precorrin-8X methylmutase; Region: CbiC; pfam02570 227882015496 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 227882015497 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 227882015498 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 227882015499 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 227882015500 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 227882015501 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 227882015502 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882015503 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 227882015504 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 227882015505 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 227882015506 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 227882015507 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 227882015508 catalytic triad [active] 227882015509 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 227882015510 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561 227882015511 homodimer interface [polypeptide binding]; other site 227882015512 Walker A motif; other site 227882015513 ATP binding site [chemical binding]; other site 227882015514 hydroxycobalamin binding site [chemical binding]; other site 227882015515 Walker B motif; other site 227882015516 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 227882015517 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882015518 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase...; Region: vWA_Magnesium_chelatase; cd01451 227882015519 metal ion-dependent adhesion site (MIDAS); other site 227882015520 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 227882015521 cobyric acid synthase; Provisional; Region: PRK00784 227882015522 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 227882015523 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 227882015524 catalytic triad [active] 227882015525 CobD/Cbib protein; Region: CobD_Cbib; cl00561 227882015526 Phosphate transporter family; Region: PHO4; cl00396 227882015527 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme (; Region: GH25_CH-type; cd06412 227882015528 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 227882015529 active site 227882015530 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 227882015531 intersubunit interface [polypeptide binding]; other site 227882015532 active site 227882015533 Zn2+ binding site [ion binding]; other site 227882015534 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 227882015535 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 227882015536 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 227882015537 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882015538 Walker A/P-loop; other site 227882015539 ATP binding site [chemical binding]; other site 227882015540 Q-loop/lid; other site 227882015541 ABC transporter signature motif; other site 227882015542 Walker B; other site 227882015543 D-loop; other site 227882015544 H-loop/switch region; other site 227882015545 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 227882015546 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 227882015547 substrate binding site [chemical binding]; other site 227882015548 oxyanion hole (OAH) forming residues; other site 227882015549 trimer interface [polypeptide binding]; other site 227882015550 Protein of unknown function (DUF322); Region: DUF322; cl00574 227882015551 Protein of unknown function (DUF322); Region: DUF322; cl00574 227882015552 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 227882015553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882015554 NAD(P) binding site [chemical binding]; other site 227882015555 active site 227882015556 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 227882015557 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 227882015558 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 227882015559 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 227882015560 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 227882015561 active site 227882015562 substrate binding site [chemical binding]; other site 227882015563 catalytic site [active] 227882015564 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882015565 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882015566 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 227882015567 hypothetical protein; Provisional; Region: PRK06194 227882015568 classical (c) SDRs; Region: SDR_c; cd05233 227882015569 NAD(P) binding site [chemical binding]; other site 227882015570 active site 227882015571 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 227882015572 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 227882015573 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 227882015574 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 227882015575 YhhN-like protein; Region: YhhN; cl01505 227882015576 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 227882015577 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 227882015578 catalytic Zn binding site [ion binding]; other site 227882015579 NAD(P) binding site [chemical binding]; other site 227882015580 structural Zn binding site [ion binding]; other site 227882015581 CoA-transferase family III; Region: CoA_transf_3; cl00778 227882015582 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 227882015583 putative active site [active] 227882015584 catalytic triad [active] 227882015585 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 227882015586 active site 227882015587 catalytic residues [active] 227882015588 Protein of unknown function, DUF485; Region: DUF485; cl01231 227882015589 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 227882015590 Sodium:solute symporter family; Region: SSF; cl00456 227882015591 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 227882015592 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 227882015593 FeS/SAM binding site; other site 227882015594 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 227882015595 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 227882015596 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 227882015597 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 227882015598 active site 227882015599 HIGH motif; other site 227882015600 dimer interface [polypeptide binding]; other site 227882015601 KMSKS motif; other site 227882015602 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 227882015603 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 227882015604 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 227882015605 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 227882015606 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 227882015607 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 227882015608 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 227882015609 NAD(P) binding site [chemical binding]; other site 227882015610 homotetramer interface [polypeptide binding]; other site 227882015611 homodimer interface [polypeptide binding]; other site 227882015612 active site 227882015613 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 227882015614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882015615 NAD(P) binding site [chemical binding]; other site 227882015616 active site 227882015617 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882015618 DNA-binding site [nucleotide binding]; DNA binding site 227882015619 FCD domain; Region: FCD; cl11656 227882015620 cyanate transporter; Region: CynX; TIGR00896 227882015621 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 227882015622 catalytic core [active] 227882015623 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 227882015624 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 227882015625 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 227882015626 motif II; other site 227882015627 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 227882015628 phosphopeptide binding site; other site 227882015629 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 227882015630 phosphopeptide binding site; other site 227882015631 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with...; Region: ABCG_EPDR; cd03213 227882015632 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 227882015633 Walker A/P-loop; other site 227882015634 ATP binding site [chemical binding]; other site 227882015635 Q-loop/lid; other site 227882015636 ABC transporter signature motif; other site 227882015637 Walker B; other site 227882015638 D-loop; other site 227882015639 H-loop/switch region; other site 227882015640 ABC-2 type transporter; Region: ABC2_membrane; cl11417 227882015641 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 227882015642 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 227882015643 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 227882015644 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 227882015645 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882015646 NAD(P) binding site [chemical binding]; other site 227882015647 active site 227882015648 GAF domain; Region: GAF; cl00853 227882015649 Histidine kinase; Region: HisKA_3; pfam07730 227882015650 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882015651 ATP binding site [chemical binding]; other site 227882015652 Mg2+ binding site [ion binding]; other site 227882015653 G-X-G motif; other site 227882015654 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882015655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882015656 active site 227882015657 phosphorylation site [posttranslational modification] 227882015658 intermolecular recognition site; other site 227882015659 dimerization interface [polypeptide binding]; other site 227882015660 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882015661 DNA binding residues [nucleotide binding] 227882015662 dimerization interface [polypeptide binding]; other site 227882015663 Small secreted domain (DUF320); Region: DUF320; pfam03777 227882015664 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 227882015665 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 227882015666 Walker A/P-loop; other site 227882015667 ATP binding site [chemical binding]; other site 227882015668 Q-loop/lid; other site 227882015669 ABC transporter signature motif; other site 227882015670 Walker B; other site 227882015671 D-loop; other site 227882015672 H-loop/switch region; other site 227882015673 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 227882015674 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 227882015675 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 227882015676 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 227882015677 active site 227882015678 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 227882015679 substrate binding site [chemical binding]; other site 227882015680 SpoOM protein; Region: Spo0M; pfam07070 227882015681 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 227882015682 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 227882015683 active site 227882015684 DNA binding site [nucleotide binding] 227882015685 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 227882015686 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 227882015687 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 227882015688 active site 227882015689 motif I; other site 227882015690 motif II; other site 227882015691 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 227882015692 ABC-ATPase subunit interface; other site 227882015693 dimer interface [polypeptide binding]; other site 227882015694 putative PBP binding regions; other site 227882015695 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 227882015696 ABC-ATPase subunit interface; other site 227882015697 dimer interface [polypeptide binding]; other site 227882015698 putative PBP binding regions; other site 227882015699 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 227882015700 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 227882015701 Walker A/P-loop; other site 227882015702 ATP binding site [chemical binding]; other site 227882015703 Q-loop/lid; other site 227882015704 ABC transporter signature motif; other site 227882015705 Walker B; other site 227882015706 D-loop; other site 227882015707 H-loop/switch region; other site 227882015708 SCP-2 sterol transfer family; Region: SCP2; cl01225 227882015709 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 227882015710 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 227882015711 RNA binding surface [nucleotide binding]; other site 227882015712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882015713 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 227882015714 ATP-NAD kinase; Region: NAD_kinase; pfam01513 227882015715 FtsX-like permease family; Region: FtsX; pfam02687 227882015716 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 227882015717 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 227882015718 Walker A/P-loop; other site 227882015719 ATP binding site [chemical binding]; other site 227882015720 Q-loop/lid; other site 227882015721 ABC transporter signature motif; other site 227882015722 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 227882015723 ABC transporter signature motif; other site 227882015724 Walker B; other site 227882015725 D-loop; other site 227882015726 H-loop/switch region; other site 227882015727 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 227882015728 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 227882015729 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 227882015730 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 227882015731 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 227882015732 CTP synthetase; Validated; Region: pyrG; PRK05380 227882015733 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 227882015734 Catalytic site [active] 227882015735 Active site [active] 227882015736 UTP binding site [chemical binding]; other site 227882015737 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 227882015738 active site 227882015739 putative oxyanion hole; other site 227882015740 catalytic triad [active] 227882015741 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 227882015742 dimer interface [polypeptide binding]; other site 227882015743 ADP-ribose binding site [chemical binding]; other site 227882015744 active site 227882015745 nudix motif; other site 227882015746 metal binding site [ion binding]; metal-binding site 227882015747 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 227882015748 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 227882015749 TPR motif; other site 227882015750 binding surface 227882015751 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 227882015752 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 227882015753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882015754 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 227882015755 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 227882015756 P-loop; other site 227882015757 Magnesium ion binding site [ion binding]; other site 227882015758 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 227882015759 Magnesium ion binding site [ion binding]; other site 227882015760 ScpA/B protein; Region: ScpA_ScpB; cl00598 227882015761 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 227882015762 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 227882015763 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 227882015764 RNA binding surface [nucleotide binding]; other site 227882015765 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 227882015766 active site 227882015767 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 227882015768 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 227882015769 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 227882015770 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 227882015771 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 227882015772 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 227882015773 iron-sulfur cluster [ion binding]; other site 227882015774 [2Fe-2S] cluster binding site [ion binding]; other site 227882015775 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In...; Region: AroH; cd02185 227882015776 homotrimer interaction site [polypeptide binding]; other site 227882015777 active site 227882015778 prephenate dehydrogenase; Validated; Region: PRK06545 227882015779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882015780 cytidylate kinase; Provisional; Region: cmk; PRK00023 227882015781 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 227882015782 CMP-binding site; other site 227882015783 The sites determining sugar specificity; other site 227882015784 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 227882015785 putative acyl-acceptor binding pocket; other site 227882015786 GTP-binding protein Der; Reviewed; Region: PRK03003 227882015787 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 227882015788 G1 box; other site 227882015789 GTP/Mg2+ binding site [chemical binding]; other site 227882015790 Switch I region; other site 227882015791 G2 box; other site 227882015792 Switch II region; other site 227882015793 G3 box; other site 227882015794 G4 box; other site 227882015795 G5 box; other site 227882015796 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 227882015797 G1 box; other site 227882015798 GTP/Mg2+ binding site [chemical binding]; other site 227882015799 Switch I region; other site 227882015800 G2 box; other site 227882015801 G3 box; other site 227882015802 Switch II region; other site 227882015803 G4 box; other site 227882015804 G5 box; other site 227882015805 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 227882015806 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 227882015807 putative peptidoglycan binding site; other site 227882015808 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 227882015809 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 227882015810 putative peptidoglycan binding site; other site 227882015811 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882015812 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 227882015813 Walker A/P-loop; other site 227882015814 ATP binding site [chemical binding]; other site 227882015815 Q-loop/lid; other site 227882015816 ABC transporter signature motif; other site 227882015817 Walker B; other site 227882015818 D-loop; other site 227882015819 H-loop/switch region; other site 227882015820 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 227882015821 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 227882015822 Walker A/P-loop; other site 227882015823 ATP binding site [chemical binding]; other site 227882015824 Q-loop/lid; other site 227882015825 ABC transporter signature motif; other site 227882015826 Walker B; other site 227882015827 D-loop; other site 227882015828 H-loop/switch region; other site 227882015829 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 227882015830 TM-ABC transporter signature motif; other site 227882015831 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 227882015832 putative ligand binding site [chemical binding]; other site 227882015833 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 227882015834 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 227882015835 putative ADP-binding pocket [chemical binding]; other site 227882015836 Predicted transcriptional regulator [Transcription]; Region: COG2378 227882015837 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 227882015838 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 227882015839 D-pathway; other site 227882015840 Putative ubiquinol binding site [chemical binding]; other site 227882015841 Low-spin heme (heme b) binding site [chemical binding]; other site 227882015842 Putative water exit pathway; other site 227882015843 Binuclear center (heme o3/CuB) [ion binding]; other site 227882015844 K-pathway; other site 227882015845 Putative proton exit pathway; other site 227882015846 Peptidase inhibitor I78 family; Region: Inhibitor_I78; pfam11720 227882015847 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 227882015848 active site 227882015849 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882015850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882015851 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882015852 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 227882015853 active site 227882015854 Protein of unknown function (DUF552); Region: DUF552; cl00775 227882015855 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 227882015856 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 227882015857 substrate binding pocket [chemical binding]; other site 227882015858 membrane-bound complex binding site; other site 227882015859 hinge residues; other site 227882015860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882015861 dimer interface [polypeptide binding]; other site 227882015862 conserved gate region; other site 227882015863 putative PBP binding loops; other site 227882015864 ABC-ATPase subunit interface; other site 227882015865 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 227882015866 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 227882015867 Walker A/P-loop; other site 227882015868 ATP binding site [chemical binding]; other site 227882015869 Q-loop/lid; other site 227882015870 ABC transporter signature motif; other site 227882015871 Walker B; other site 227882015872 D-loop; other site 227882015873 H-loop/switch region; other site 227882015874 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882015875 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 227882015876 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 227882015877 active site 227882015878 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 227882015879 non-prolyl cis peptide bond; other site 227882015880 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882015881 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 227882015882 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 227882015883 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 227882015884 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 227882015885 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 227882015886 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 227882015887 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 227882015888 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 227882015889 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 227882015890 generic binding surface II; other site 227882015891 generic binding surface I; other site 227882015892 Y-family of DNA polymerases; Region: PolY; cl12025 227882015893 DNA binding site [nucleotide binding] 227882015894 Cupin domain; Region: Cupin_2; cl09118 227882015895 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882015896 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 227882015897 Chitin binding domain; Region: Chitin_bind_3; cl03871 227882015898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 227882015899 Coenzyme A binding pocket [chemical binding]; other site 227882015900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882015901 S-adenosylmethionine binding site [chemical binding]; other site 227882015902 Protein of unknown function (DUF402); Region: DUF402; cl00979 227882015903 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 227882015904 Coenzyme A binding pocket [chemical binding]; other site 227882015905 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882015906 DNA-binding site [nucleotide binding]; DNA binding site 227882015907 Protein of unknown function DUF72; Region: DUF72; cl00777 227882015908 replication factor C subunit; Provisional; Region: PLN03025 227882015909 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 227882015910 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882015911 Walker A motif; other site 227882015912 ATP binding site [chemical binding]; other site 227882015913 Walker B motif; other site 227882015914 arginine finger; other site 227882015915 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; cl10042 227882015916 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 227882015917 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 227882015918 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 227882015919 active site 227882015920 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 227882015921 Ligand binding site [chemical binding]; other site 227882015922 Putative Catalytic site [active] 227882015923 DXD motif; other site 227882015924 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 227882015925 Protein of unknown function (DUF1616); Region: DUF1616; cl01959 227882015926 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 227882015927 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 227882015928 calcium binding site 2 [ion binding]; other site 227882015929 active site 227882015930 catalytic triad [active] 227882015931 calcium binding site 1 [ion binding]; other site 227882015932 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 227882015933 active site 227882015934 catalytic triad [active] 227882015935 oxyanion hole [active] 227882015936 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882015937 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882015938 active site 227882015939 ATP binding site [chemical binding]; other site 227882015940 substrate binding site [chemical binding]; other site 227882015941 activation loop (A-loop); other site 227882015942 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 227882015943 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 227882015944 TPR motif; other site 227882015945 binding surface 227882015946 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 227882015947 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 227882015948 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882015949 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882015950 DNA binding residues [nucleotide binding] 227882015951 Anti-sigma-K factor rskA; Region: RskA; cl02208 227882015952 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 227882015953 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882015954 DNA-binding site [nucleotide binding]; DNA binding site 227882015955 UTRA domain; Region: UTRA; cl01230 227882015956 homogentisate 1,2-dioxygenase; Region: HgmA; cl10473 227882015957 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882015958 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882015959 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 227882015960 putative [Fe4-S4] binding site [ion binding]; other site 227882015961 putative molybdopterin cofactor binding site [chemical binding]; other site 227882015962 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 227882015963 putative molybdopterin cofactor binding site; other site 227882015964 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 227882015965 Citrate transporter; Region: CitMHS; pfam03600 227882015966 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882015967 putative substrate translocation pore; other site 227882015968 Major Facilitator Superfamily; Region: MFS_1; pfam07690 227882015969 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan...; Region: Sortase_E; cd05829 227882015970 active site 227882015971 putative catalytic site [active] 227882015972 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 227882015973 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 227882015974 NAD binding site [chemical binding]; other site 227882015975 catalytic residues [active] 227882015976 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 227882015977 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 227882015978 NAD binding site [chemical binding]; other site 227882015979 catalytic Zn binding site [ion binding]; other site 227882015980 substrate binding site [chemical binding]; other site 227882015981 structural Zn binding site [ion binding]; other site 227882015982 EamA-like transporter family; Region: EamA; cl01037 227882015983 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 227882015984 putative DNA binding site [nucleotide binding]; other site 227882015985 dimerization interface [polypeptide binding]; other site 227882015986 putative Zn2+ binding site [ion binding]; other site 227882015987 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882015988 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 227882015989 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 227882015990 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882015991 active site 227882015992 yiaA/B two helix domain; Region: YiaAB; cl01759 227882015993 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882015994 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882015995 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 227882015996 putative active site [active] 227882015997 putative catalytic site [active] 227882015998 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 227882015999 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 227882016000 DNA binding residues [nucleotide binding] 227882016001 RNA ligase, DRB0094 family; Region: RNA_lig_DRB0094; TIGR02306 227882016002 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human tyrosyl-; Region: tRNA_bindingDomain; cl00320 227882016003 putative tRNA-binding site [nucleotide binding]; other site 227882016004 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 227882016005 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 227882016006 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a four-...; Region: Ntn_hydrolase; cl00467 227882016007 active site 227882016008 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 227882016009 classical (c) SDRs; Region: SDR_c; cd05233 227882016010 NAD(P) binding site [chemical binding]; other site 227882016011 active site 227882016012 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 227882016013 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882016014 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882016015 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 227882016016 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 227882016017 FAD binding site [chemical binding]; other site 227882016018 substrate binding site [chemical binding]; other site 227882016019 catalytic base [active] 227882016020 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: ACAD10_11_like; cd05154 227882016021 Phosphotransferase enzyme family; Region: APH; pfam01636 227882016022 putative active site [active] 227882016023 putative substrate binding site [chemical binding]; other site 227882016024 ATP binding site [chemical binding]; other site 227882016025 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 227882016026 Domain of unknown function DUF; Region: DUF202; cl09954 227882016027 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 227882016028 nudix motif; other site 227882016029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882016030 hypothetical protein; Validated; Region: PRK07121 227882016031 Amino acid permease; Region: AA_permease; pfam00324 227882016032 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882016033 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 227882016034 Moco binding site; other site 227882016035 metal coordination site [ion binding]; other site 227882016036 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 227882016037 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 227882016038 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 227882016039 putative NAD(P) binding site [chemical binding]; other site 227882016040 catalytic Zn binding site [ion binding]; other site 227882016041 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 227882016042 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 227882016043 NADP binding site [chemical binding]; other site 227882016044 homodimer interface [polypeptide binding]; other site 227882016045 active site 227882016046 GntP family permease; Region: GntP_permease; cl15264 227882016047 gluconate transporter; Region: gntP; TIGR00791 227882016048 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 227882016049 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 227882016050 Transcriptional regulators [Transcription]; Region: FadR; COG2186 227882016051 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882016052 DNA-binding site [nucleotide binding]; DNA binding site 227882016053 FCD domain; Region: FCD; cl11656 227882016054 SEC-C motif; Region: SEC-C; cl12132 227882016055 hypothetical protein; Provisional; Region: PRK04233 227882016056 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 227882016057 Zn binding site [ion binding]; other site 227882016058 peptide synthase; Provisional; Region: PRK12467 227882016059 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882016060 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 227882016061 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 227882016062 putative CoA binding site [chemical binding]; other site 227882016063 putative trimer interface [polypeptide binding]; other site 227882016064 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 227882016065 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 227882016066 putative trimer interface [polypeptide binding]; other site 227882016067 putative CoA binding site [chemical binding]; other site 227882016068 hypothetical protein; Provisional; Region: PRK07906 227882016069 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 227882016070 putative metal binding site [ion binding]; other site 227882016071 Small secreted domain (DUF320); Region: DUF320; pfam03777 227882016072 Small secreted domain (DUF320); Region: DUF320; pfam03777 227882016073 RecD/TraA family; Region: recD_rel; TIGR01448 227882016074 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 227882016075 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 227882016076 active site 227882016077 catalytic tetrad [active] 227882016078 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 227882016079 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 227882016080 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 227882016081 dinuclear metal binding motif [ion binding]; other site 227882016082 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 227882016083 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 227882016084 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 227882016085 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 227882016086 catalytic core [active] 227882016087 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 227882016088 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (...; Region: PI3Kc_like; cl00119 227882016089 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 227882016090 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 227882016091 active site 227882016092 HIGH motif; other site 227882016093 nucleotide binding site [chemical binding]; other site 227882016094 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 227882016095 active site 227882016096 KMSKS motif; other site 227882016097 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 227882016098 tRNA binding surface [nucleotide binding]; other site 227882016099 anticodon binding site; other site 227882016100 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 227882016101 putative active site [active] 227882016102 putative catalytic triad [active] 227882016103 PAC2 family; Region: PAC2; cl00847 227882016104 Transcriptional regulators [Transcription]; Region: FadR; COG2186 227882016105 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882016106 DNA-binding site [nucleotide binding]; DNA binding site 227882016107 FCD domain; Region: FCD; cl11656 227882016108 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 227882016109 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 227882016110 active site 227882016111 putative substrate binding pocket [chemical binding]; other site 227882016112 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 227882016113 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 227882016114 TM-ABC transporter signature motif; other site 227882016115 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 227882016116 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 227882016117 TM-ABC transporter signature motif; other site 227882016118 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 227882016119 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 227882016120 Walker A/P-loop; other site 227882016121 ATP binding site [chemical binding]; other site 227882016122 Q-loop/lid; other site 227882016123 ABC transporter signature motif; other site 227882016124 Walker B; other site 227882016125 D-loop; other site 227882016126 H-loop/switch region; other site 227882016127 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 227882016128 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 227882016129 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 227882016130 ligand binding site [chemical binding]; other site 227882016131 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 227882016132 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 227882016133 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 227882016134 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882016135 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 227882016136 Cupin domain; Region: Cupin_2; cl09118 227882016137 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882016138 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 227882016139 glycerol kinase; Region: glycerol_kin; TIGR01311 227882016140 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 227882016141 N- and C-terminal domain interface [polypeptide binding]; other site 227882016142 putative active site [active] 227882016143 putative MgATP binding site [chemical binding]; other site 227882016144 catalytic site [active] 227882016145 metal binding site [ion binding]; metal-binding site 227882016146 putative homotetramer interface [polypeptide binding]; other site 227882016147 putative glycerol binding site [chemical binding]; other site 227882016148 homodimer interface [polypeptide binding]; other site 227882016149 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333 227882016150 amphipathic channel; other site 227882016151 Asn-Pro-Ala signature motifs; other site 227882016152 Transcriptional regulator [Transcription]; Region: IclR; COG1414 227882016153 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882016154 Bacterial transcriptional regulator; Region: IclR; pfam01614 227882016155 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 227882016156 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 227882016157 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 227882016158 substrate binding pocket [chemical binding]; other site 227882016159 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 227882016160 B12 binding site [chemical binding]; other site 227882016161 cobalt ligand [ion binding]; other site 227882016162 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 227882016163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882016164 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 227882016165 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 227882016166 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 227882016167 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 227882016168 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 227882016169 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882016170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882016171 active site 227882016172 phosphorylation site [posttranslational modification] 227882016173 intermolecular recognition site; other site 227882016174 dimerization interface [polypeptide binding]; other site 227882016175 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882016176 DNA binding residues [nucleotide binding] 227882016177 dimerization interface [polypeptide binding]; other site 227882016178 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 227882016179 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 227882016180 active site 227882016181 putative substrate binding region [chemical binding]; other site 227882016182 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 227882016183 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 227882016184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882016185 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 227882016186 proteasome ATPase; Region: pup_AAA; TIGR03689 227882016187 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882016188 Walker A motif; other site 227882016189 ATP binding site [chemical binding]; other site 227882016190 Walker B motif; other site 227882016191 arginine finger; other site 227882016192 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 227882016193 Pup-ligase protein; Region: Pup_ligase; pfam03136 227882016194 Pup-like protein; Region: Pup; cl05289 227882016195 Recombination endonuclease VII; Region: Endonuclease_7; pfam02945 227882016196 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded...; Region: proteasome_protease_HslV; cd01906 227882016197 active site 227882016198 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 227882016199 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded...; Region: proteasome_protease_HslV; cd01906 227882016200 active site 227882016201 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 227882016202 ligand binding site [chemical binding]; other site 227882016203 dimerization interface [polypeptide binding]; other site 227882016204 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 227882016205 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 227882016206 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 227882016207 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 227882016208 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 227882016209 Predicted transcriptional regulator [Transcription]; Region: COG2378 227882016210 Predicted transcriptional regulator [Transcription]; Region: COG2378 227882016211 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 227882016212 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 227882016213 diacylglycerol kinase; Reviewed; Region: PRK11914 227882016214 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 227882016215 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 227882016216 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 227882016217 ATP binding site [chemical binding]; other site 227882016218 putative Mg++ binding site [ion binding]; other site 227882016219 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 227882016220 nucleotide binding region [chemical binding]; other site 227882016221 ATP-binding site [chemical binding]; other site 227882016222 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 227882016223 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 227882016224 active site 227882016225 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 227882016226 dimer interface [polypeptide binding]; other site 227882016227 non-prolyl cis peptide bond; other site 227882016228 insertion regions; other site 227882016229 allophanate hydrolase; Provisional; Region: PRK08186 227882016230 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 227882016231 urea carboxylase; Region: urea_carbox; TIGR02712 227882016232 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 227882016233 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 227882016234 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 227882016235 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 227882016236 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 227882016237 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 227882016238 carboxyltransferase (CT) interaction site; other site 227882016239 biotinylation site [posttranslational modification]; other site 227882016240 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 227882016241 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 227882016242 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882016243 ATP binding site [chemical binding]; other site 227882016244 Mg2+ binding site [ion binding]; other site 227882016245 G-X-G motif; other site 227882016246 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 227882016247 Protein of unknown function (DUF742); Region: DUF742; pfam05331 227882016248 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 227882016249 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 227882016250 G2 box; other site 227882016251 Switch I region; other site 227882016252 G3 box; other site 227882016253 Switch II region; other site 227882016254 G4 box; other site 227882016255 G5 box; other site 227882016256 Cytochrome P450; Region: p450; cl12078 227882016257 PSRA_1: Pseudouridine synthase, a subgroup of the RluA family. This group is comprised of bacterial proteins assigned to the RluA family of pseudouridine synthases. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PSRA_1; cd02558 227882016258 probable active site [active] 227882016259 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 227882016260 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882016261 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882016262 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882016263 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882016264 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 227882016265 Walker A/P-loop; other site 227882016266 ATP binding site [chemical binding]; other site 227882016267 Q-loop/lid; other site 227882016268 ABC transporter signature motif; other site 227882016269 Walker B; other site 227882016270 D-loop; other site 227882016271 H-loop/switch region; other site 227882016272 ABC-2 type transporter; Region: ABC2_membrane; cl11417 227882016273 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 227882016274 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 227882016275 FAD binding pocket [chemical binding]; other site 227882016276 FAD binding motif [chemical binding]; other site 227882016277 phosphate binding motif [ion binding]; other site 227882016278 NAD binding pocket [chemical binding]; other site 227882016279 5'-3' exonuclease; Region: 53EXOc; smart00475 227882016280 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 227882016281 active site 227882016282 metal binding site 1 [ion binding]; metal-binding site 227882016283 putative 5' ssDNA interaction site; other site 227882016284 metal binding site 3; metal-binding site 227882016285 metal binding site 2 [ion binding]; metal-binding site 227882016286 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 227882016287 putative DNA binding site [nucleotide binding]; other site 227882016288 putative metal binding site [ion binding]; other site 227882016289 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 227882016290 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 227882016291 Walker A/P-loop; other site 227882016292 ATP binding site [chemical binding]; other site 227882016293 Q-loop/lid; other site 227882016294 ABC transporter signature motif; other site 227882016295 Walker B; other site 227882016296 D-loop; other site 227882016297 H-loop/switch region; other site 227882016298 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 227882016299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882016300 dimer interface [polypeptide binding]; other site 227882016301 conserved gate region; other site 227882016302 putative PBP binding loops; other site 227882016303 ABC-ATPase subunit interface; other site 227882016304 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 227882016305 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 227882016306 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 227882016307 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 227882016308 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882016309 Cupin domain; Region: Cupin_2; cl09118 227882016310 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882016311 S-adenosylmethionine binding site [chemical binding]; other site 227882016312 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 227882016313 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 227882016314 intersubunit interface [polypeptide binding]; other site 227882016315 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_2; cd09320 227882016316 C4-dicarboxylate transporter/malic acid transport protein; Region: C4dic_mal_tran; pfam03595 227882016317 gating phenylalanine in ion channel; other site 227882016318 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882016319 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 227882016320 putative dimerization interface [polypeptide binding]; other site 227882016321 Peptidase C26; Region: Peptidase_C26; pfam07722 227882016322 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 227882016323 catalytic triad [active] 227882016324 Transcriptional regulators [Transcription]; Region: FadR; COG2186 227882016325 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882016326 DNA-binding site [nucleotide binding]; DNA binding site 227882016327 FCD domain; Region: FCD; cl11656 227882016328 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 227882016329 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 227882016330 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 227882016331 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 227882016332 NAD(P) binding site [chemical binding]; other site 227882016333 catalytic residues [active] 227882016334 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 227882016335 classical (c) SDRs; Region: SDR_c; cd05233 227882016336 NAD(P) binding site [chemical binding]; other site 227882016337 active site 227882016338 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882016339 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 227882016340 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 227882016341 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 227882016342 dimer interface [polypeptide binding]; other site 227882016343 active site 227882016344 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 227882016345 substrate binding site [chemical binding]; other site 227882016346 catalytic residue [active] 227882016347 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 227882016348 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 227882016349 active site 227882016350 catalytic residues [active] 227882016351 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 227882016352 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 227882016353 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 227882016354 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 227882016355 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 227882016356 23S rRNA binding site [nucleotide binding]; other site 227882016357 L21 binding site [polypeptide binding]; other site 227882016358 L13 binding site [polypeptide binding]; other site 227882016359 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 227882016360 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 227882016361 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 227882016362 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 227882016363 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 227882016364 dimer interface [polypeptide binding]; other site 227882016365 phosphorylation site [posttranslational modification] 227882016366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882016367 ATP binding site [chemical binding]; other site 227882016368 Mg2+ binding site [ion binding]; other site 227882016369 G-X-G motif; other site 227882016370 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 227882016371 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 227882016372 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 227882016373 dimer interface [polypeptide binding]; other site 227882016374 motif 1; other site 227882016375 active site 227882016376 motif 2; other site 227882016377 motif 3; other site 227882016378 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 227882016379 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 227882016380 putative tRNA-binding site [nucleotide binding]; other site 227882016381 B3/4 domain; Region: B3_4; cl11458 227882016382 tRNA synthetase B5 domain; Region: B5; cl08394 227882016383 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 227882016384 dimer interface [polypeptide binding]; other site 227882016385 motif 1; other site 227882016386 motif 3; other site 227882016387 motif 2; other site 227882016388 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 227882016389 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882016390 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882016391 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 227882016392 dimer interface [polypeptide binding]; other site 227882016393 active site 227882016394 ADP-ribose binding site [chemical binding]; other site 227882016395 nudix motif; other site 227882016396 metal binding site [ion binding]; metal-binding site 227882016397 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 227882016398 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 227882016399 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 227882016400 Uncharacterised BCR, COG1649; Region: DUF187; pfam02638 227882016401 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 227882016402 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882016403 DNA-binding site [nucleotide binding]; DNA binding site 227882016404 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 227882016405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882016406 homodimer interface [polypeptide binding]; other site 227882016407 catalytic residue [active] 227882016408 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882016409 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 227882016410 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 227882016411 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 227882016412 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 227882016413 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 227882016414 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 227882016415 DNA binding residues [nucleotide binding] 227882016416 putative dimer interface [polypeptide binding]; other site 227882016417 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 227882016418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882016419 NAD(P) binding site [chemical binding]; other site 227882016420 active site 227882016421 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 227882016422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882016423 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 227882016424 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 227882016425 heterotetramer interface [polypeptide binding]; other site 227882016426 active site pocket [active] 227882016427 cleavage site 227882016428 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250 227882016429 feedback inhibition sensing region; other site 227882016430 homohexameric interface [polypeptide binding]; other site 227882016431 carbamate kinase; Reviewed; Region: PRK12686 227882016432 nucleotide binding site [chemical binding]; other site 227882016433 N-acetyl-L-glutamate binding site [chemical binding]; other site 227882016434 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 227882016435 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 227882016436 inhibitor-cofactor binding pocket; inhibition site 227882016437 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882016438 catalytic residue [active] 227882016439 arginine repressor; Provisional; Region: PRK03341 227882016440 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 227882016441 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 227882016442 ApbE family; Region: ApbE; cl00643 227882016443 FMN-binding domain; Region: FMN_bind; cl01081 227882016444 FMN-binding domain; Region: FMN_bind; cl01081 227882016445 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 227882016446 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 227882016447 FAD binding pocket [chemical binding]; other site 227882016448 FAD binding motif [chemical binding]; other site 227882016449 phosphate binding motif [ion binding]; other site 227882016450 beta-alpha-beta structure motif; other site 227882016451 NAD binding pocket [chemical binding]; other site 227882016452 FMN-binding domain; Region: FMN_bind; cl01081 227882016453 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 227882016454 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 227882016455 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 227882016456 FAD binding pocket [chemical binding]; other site 227882016457 FAD binding motif [chemical binding]; other site 227882016458 phosphate binding motif [ion binding]; other site 227882016459 beta-alpha-beta structure motif; other site 227882016460 NAD binding pocket [chemical binding]; other site 227882016461 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 227882016462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882016463 active site 227882016464 phosphorylation site [posttranslational modification] 227882016465 intermolecular recognition site; other site 227882016466 dimerization interface [polypeptide binding]; other site 227882016467 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 227882016468 DNA binding site [nucleotide binding] 227882016469 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882016470 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 227882016471 dimer interface [polypeptide binding]; other site 227882016472 phosphorylation site [posttranslational modification] 227882016473 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882016474 ATP binding site [chemical binding]; other site 227882016475 Mg2+ binding site [ion binding]; other site 227882016476 G-X-G motif; other site 227882016477 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 227882016478 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 227882016479 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 227882016480 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 227882016481 ANP binding site [chemical binding]; other site 227882016482 Substrate Binding Site II [chemical binding]; other site 227882016483 Substrate Binding Site I [chemical binding]; other site 227882016484 argininosuccinate lyase; Provisional; Region: PRK00855 227882016485 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 227882016486 active sites [active] 227882016487 tetramer interface [polypeptide binding]; other site 227882016488 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 227882016489 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 227882016490 active site 227882016491 catalytic tetrad [active] 227882016492 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882016493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882016494 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 227882016495 putative acyl-acceptor binding pocket; other site 227882016496 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 227882016497 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 227882016498 putative active site [active] 227882016499 catalytic site [active] 227882016500 putative metal binding site [ion binding]; other site 227882016501 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882016502 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 227882016503 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 227882016504 Walker A/P-loop; other site 227882016505 ATP binding site [chemical binding]; other site 227882016506 Q-loop/lid; other site 227882016507 ABC transporter signature motif; other site 227882016508 Walker B; other site 227882016509 D-loop; other site 227882016510 H-loop/switch region; other site 227882016511 NIL domain; Region: NIL; cl09633 227882016512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882016513 dimer interface [polypeptide binding]; other site 227882016514 conserved gate region; other site 227882016515 putative PBP binding loops; other site 227882016516 ABC-ATPase subunit interface; other site 227882016517 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 227882016518 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 227882016519 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 227882016520 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882016521 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 227882016522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882016523 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(; Region: BluB; cd02145 227882016524 putative FMN binding site [chemical binding]; other site 227882016525 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 227882016526 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 227882016527 putative dimer interface [polypeptide binding]; other site 227882016528 active site pocket [active] 227882016529 putative cataytic base [active] 227882016530 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 227882016531 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 227882016532 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 227882016533 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 227882016534 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 227882016535 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 227882016536 active site 227882016537 8-oxo-dGMP binding site [chemical binding]; other site 227882016538 nudix motif; other site 227882016539 metal binding site [ion binding]; metal-binding site 227882016540 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882016541 Catalytic domain of Protein Kinases; Region: PKc; cd00180 227882016542 active site 227882016543 ATP binding site [chemical binding]; other site 227882016544 substrate binding site [chemical binding]; other site 227882016545 activation loop (A-loop); other site 227882016546 Phosphotransferase enzyme family; Region: APH; pfam01636 227882016547 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882016548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3809 227882016549 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 227882016550 chorismate binding enzyme; Region: Chorismate_bind; cl10555 227882016551 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 227882016552 Aminotransferase class IV; Region: Aminotran_4; pfam01063 227882016553 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882016554 catalytic residue [active] 227882016555 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882016556 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 227882016557 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 227882016558 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 227882016559 CGNR zinc finger; Region: zf-CGNR; pfam11706 227882016560 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 227882016561 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 227882016562 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 227882016563 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882016564 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 227882016565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882016566 ABC-ATPase subunit interface; other site 227882016567 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882016568 dimer interface [polypeptide binding]; other site 227882016569 conserved gate region; other site 227882016570 putative PBP binding loops; other site 227882016571 ABC-ATPase subunit interface; other site 227882016572 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 227882016573 putative hydrophobic ligand binding site [chemical binding]; other site 227882016574 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 227882016575 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 227882016576 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 227882016577 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 227882016578 active site 227882016579 dimer interface [polypeptide binding]; other site 227882016580 motif 1; other site 227882016581 motif 2; other site 227882016582 motif 3; other site 227882016583 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 227882016584 anticodon binding site; other site 227882016585 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 227882016586 nucleotide binding site/active site [active] 227882016587 HIT family signature motif; other site 227882016588 catalytic residue [active] 227882016589 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G_bact; cd04170 227882016590 elongation factor G; Reviewed; Region: PRK12740 227882016591 G1 box; other site 227882016592 putative GEF interaction site [polypeptide binding]; other site 227882016593 GTP/Mg2+ binding site [chemical binding]; other site 227882016594 Switch I region; other site 227882016595 G2 box; other site 227882016596 G3 box; other site 227882016597 Switch II region; other site 227882016598 G4 box; other site 227882016599 G5 box; other site 227882016600 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 227882016601 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 227882016602 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 227882016603 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 227882016604 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882016605 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 227882016606 putative acyl-acceptor binding pocket; other site 227882016607 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 227882016608 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 227882016609 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 227882016610 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 227882016611 active site 227882016612 multimer interface [polypeptide binding]; other site 227882016613 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 227882016614 predicted active site [active] 227882016615 catalytic triad [active] 227882016616 Domain of unknown function DUF28; Region: DUF28; cl00361 227882016617 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 227882016618 active site 227882016619 putative DNA-binding cleft [nucleotide binding]; other site 227882016620 dimer interface [polypeptide binding]; other site 227882016621 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 227882016622 RuvA N terminal domain; Region: RuvA_N; pfam01330 227882016623 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 227882016624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882016625 Walker A motif; other site 227882016626 ATP binding site [chemical binding]; other site 227882016627 Walker B motif; other site 227882016628 arginine finger; other site 227882016629 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 227882016630 Preprotein translocase subunit; Region: YajC; cl00806 227882016631 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 227882016632 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 227882016633 Protein export membrane protein; Region: SecD_SecF; cl14618 227882016634 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 227882016635 Protein export membrane protein; Region: SecD_SecF; cl14618 227882016636 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 227882016637 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 227882016638 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 227882016639 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 227882016640 synthetase active site [active] 227882016641 NTP binding site [chemical binding]; other site 227882016642 metal binding site [ion binding]; metal-binding site 227882016643 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 227882016644 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 227882016645 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 227882016646 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 227882016647 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 227882016648 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 227882016649 active site 227882016650 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 227882016651 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 227882016652 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 227882016653 dimer interface [polypeptide binding]; other site 227882016654 motif 1; other site 227882016655 active site 227882016656 motif 2; other site 227882016657 motif 3; other site 227882016658 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 227882016659 anticodon binding site; other site 227882016660 Vitamin K epoxide reductase family; Region: VKOR; cl01729 227882016661 recombination factor protein RarA; Reviewed; Region: PRK13342 227882016662 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882016663 Walker A motif; other site 227882016664 ATP binding site [chemical binding]; other site 227882016665 Walker B motif; other site 227882016666 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 227882016667 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 227882016668 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 227882016669 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 227882016670 RNA binding surface [nucleotide binding]; other site 227882016671 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 227882016672 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 227882016673 motif 1; other site 227882016674 active site 227882016675 motif 2; other site 227882016676 motif 3; other site 227882016677 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 227882016678 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 227882016679 YceG-like family; Region: YceG; pfam02618 227882016680 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 227882016681 dimerization interface [polypeptide binding]; other site 227882016682 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 227882016683 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 227882016684 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 227882016685 shikimate binding site; other site 227882016686 NAD(P) binding site [chemical binding]; other site 227882016687 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 227882016688 Tetramer interface [polypeptide binding]; other site 227882016689 Active site [active] 227882016690 FMN-binding site [chemical binding]; other site 227882016691 shikimate kinase; Reviewed; Region: aroK; PRK00131 227882016692 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 227882016693 ADP binding site [chemical binding]; other site 227882016694 magnesium binding site [ion binding]; other site 227882016695 putative shikimate binding site; other site 227882016696 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 227882016697 active site 227882016698 dimer interface [polypeptide binding]; other site 227882016699 metal binding site [ion binding]; metal-binding site 227882016700 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882016701 Active site [active] 227882016702 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 227882016703 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 227882016704 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 227882016705 active site 227882016706 elongation factor P; Validated; Region: PRK00529 227882016707 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 227882016708 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 227882016709 RNA binding site [nucleotide binding]; other site 227882016710 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 227882016711 RNA binding site [nucleotide binding]; other site 227882016712 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 227882016713 putative RNA binding site [nucleotide binding]; other site 227882016714 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882016715 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 227882016716 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 227882016717 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 227882016718 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882016719 dihydroorotase; Validated; Region: pyrC; PRK09357 227882016720 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 227882016721 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 227882016722 active site 227882016723 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 227882016724 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 227882016725 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 227882016726 catalytic site [active] 227882016727 subunit interface [polypeptide binding]; other site 227882016728 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 227882016729 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 227882016730 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 227882016731 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 227882016732 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 227882016733 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 227882016734 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 227882016735 IMP binding site; other site 227882016736 dimer interface [polypeptide binding]; other site 227882016737 interdomain contacts; other site 227882016738 partial ornithine binding site; other site 227882016739 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_2_like; cd04738 227882016740 quinone interaction residues [chemical binding]; other site 227882016741 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 227882016742 active site 227882016743 catalytic residues [active] 227882016744 FMN binding site [chemical binding]; other site 227882016745 substrate binding site [chemical binding]; other site 227882016746 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 227882016747 active site 227882016748 dimer interface [polypeptide binding]; other site 227882016749 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 227882016750 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 227882016751 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 227882016752 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 227882016753 catalytic site [active] 227882016754 G-X2-G-X-G-K; other site 227882016755 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 227882016756 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 227882016757 Flavoprotein; Region: Flavoprotein; cl08021 227882016758 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 227882016759 S-adenosylmethionine synthetase; Validated; Region: PRK05250 227882016760 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 227882016761 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 227882016762 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 227882016763 primosome assembly protein PriA; Provisional; Region: PRK14873 227882016764 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 227882016765 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 227882016766 putative active site [active] 227882016767 substrate binding site [chemical binding]; other site 227882016768 putative cosubstrate binding site; other site 227882016769 catalytic site [active] 227882016770 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 227882016771 substrate binding site [chemical binding]; other site 227882016772 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 227882016773 putative RNA binding site [nucleotide binding]; other site 227882016774 16S rRNA methyltransferase B; Provisional; Region: PRK14902 227882016775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882016776 Transport protein; Region: actII; TIGR00833 227882016777 Transport protein; Region: actII; TIGR00833 227882016778 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 227882016779 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 227882016780 substrate binding site [chemical binding]; other site 227882016781 hexamer interface [polypeptide binding]; other site 227882016782 metal binding site [ion binding]; metal-binding site 227882016783 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 227882016784 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 227882016785 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a...; Region: RNase_Sa; cd00607 227882016786 active site 227882016787 barstar interaction site; other site 227882016788 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 227882016789 putative RNAase interaction site [polypeptide binding]; other site 227882016790 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 227882016791 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 227882016792 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 227882016793 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 227882016794 active site 227882016795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 227882016796 Coenzyme A binding pocket [chemical binding]; other site 227882016797 histone acetyltransferase, ELP3 family; Region: ELP3; TIGR01211 227882016798 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 227882016799 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882016800 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 227882016801 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882016802 UTRA domain; Region: UTRA; cl01230 227882016803 Nitrate and nitrite sensing; Region: NIT; pfam08376 227882016804 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882016805 ATP binding site [chemical binding]; other site 227882016806 Mg2+ binding site [ion binding]; other site 227882016807 G-X-G motif; other site 227882016808 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 227882016809 Protein of unknown function (DUF742); Region: DUF742; pfam05331 227882016810 Predicted amidohydrolase [General function prediction only]; Region: COG0388 227882016811 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 227882016812 putative active site [active] 227882016813 catalytic triad [active] 227882016814 putative dimer interface [polypeptide binding]; other site 227882016815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882016816 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 227882016817 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 227882016818 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882016819 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 227882016820 Sulfate transporter family; Region: Sulfate_transp; cl00967 227882016821 Permease family; Region: Xan_ur_permease; pfam00860 227882016822 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 227882016823 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 227882016824 active site 227882016825 NADH dehydrogenase subunit G; Validated; Region: PRK07860 227882016826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882016827 putative substrate translocation pore; other site 227882016828 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 227882016829 dimerization interface [polypeptide binding]; other site 227882016830 putative DNA binding site [nucleotide binding]; other site 227882016831 putative Zn2+ binding site [ion binding]; other site 227882016832 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 227882016833 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882016834 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 227882016835 Lumazine binding domain; Region: Lum_binding; pfam00677 227882016836 Lumazine binding domain; Region: Lum_binding; pfam00677 227882016837 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 227882016838 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 227882016839 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 227882016840 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 227882016841 dimerization interface [polypeptide binding]; other site 227882016842 active site 227882016843 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 227882016844 homopentamer interface [polypeptide binding]; other site 227882016845 active site 227882016846 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 227882016847 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 227882016848 ATP phosphoribosyltransferase; Region: HisG; cl15266 227882016849 HisG, C-terminal domain; Region: HisG_C; cl06867 227882016850 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 227882016851 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 227882016852 Domain of unknown function DUF21; Region: DUF21; pfam01595 227882016853 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 227882016854 Transporter associated domain; Region: CorC_HlyC; cl08393 227882016855 Domain of unknown function DUF21; Region: DUF21; pfam01595 227882016856 FOG: CBS domain [General function prediction only]; Region: COG0517 227882016857 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 227882016858 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 227882016859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882016860 Walker A motif; other site 227882016861 ATP binding site [chemical binding]; other site 227882016862 Walker B motif; other site 227882016863 arginine finger; other site 227882016864 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882016865 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882016866 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 227882016867 putative active site [active] 227882016868 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882016869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882016870 Glyco_18 domain; Region: Glyco_18; smart00636 227882016871 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is...; Region: GH18_chitinase; cd06548 227882016872 active site 227882016873 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 227882016874 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882016875 active site 227882016876 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 227882016877 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882016878 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 227882016879 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 227882016880 active site 227882016881 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 227882016882 Ligand binding site [chemical binding]; other site 227882016883 Putative Catalytic site [active] 227882016884 DXD motif; other site 227882016885 FxsA cytoplasmic membrane protein; Region: FxsA; cl01148 227882016886 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 227882016887 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 227882016888 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 227882016889 putative active site [active] 227882016890 catalytic site [active] 227882016891 putative metal binding site [ion binding]; other site 227882016892 Predicted membrane protein [Function unknown]; Region: COG2364 227882016893 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 227882016894 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 227882016895 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882016896 DNA-binding site [nucleotide binding]; DNA binding site 227882016897 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 227882016898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882016899 homodimer interface [polypeptide binding]; other site 227882016900 catalytic residue [active] 227882016901 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882016902 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 227882016903 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 227882016904 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814 227882016905 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 227882016906 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814 227882016907 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 227882016908 active site 227882016909 catalytic triad [active] 227882016910 oxyanion hole [active] 227882016911 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 227882016912 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 227882016913 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 227882016914 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 227882016915 LamB/YcsF family; Region: LamB_YcsF; cl00664 227882016916 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 227882016917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882016918 benzoate transport; Region: 2A0115; TIGR00895 227882016919 putative substrate translocation pore; other site 227882016920 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 227882016921 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882016922 DNA-binding site [nucleotide binding]; DNA binding site 227882016923 FCD domain; Region: FCD; cl11656 227882016924 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 227882016925 choline dehydrogenase; Validated; Region: PRK02106 227882016926 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 227882016927 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882016928 Amino acid permease; Region: AA_permease; pfam00324 227882016929 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 227882016930 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 227882016931 NAD(P) binding site [chemical binding]; other site 227882016932 catalytic residues [active] 227882016933 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 227882016934 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 227882016935 [2Fe-2S] cluster binding site [ion binding]; other site 227882016936 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 227882016937 putative alpha subunit interface [polypeptide binding]; other site 227882016938 putative active site [active] 227882016939 putative substrate binding site [chemical binding]; other site 227882016940 Fe binding site [ion binding]; other site 227882016941 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 227882016942 sarcosine oxidase, monomeric form; Region: soxA_mon; TIGR01377 227882016943 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 227882016944 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 227882016945 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 227882016946 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 227882016947 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 227882016948 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 227882016949 mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 227882016950 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 227882016951 NAD binding site [chemical binding]; other site 227882016952 catalytic Zn binding site [ion binding]; other site 227882016953 substrate binding site [chemical binding]; other site 227882016954 structural Zn binding site [ion binding]; other site 227882016955 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882016956 Transcriptional regulator [Transcription]; Region: IclR; COG1414 227882016957 Bacterial transcriptional regulator; Region: IclR; pfam01614 227882016958 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise...; Region: Rieske_RO_ferredoxin; cd03528 227882016959 [2Fe-2S] cluster binding site [ion binding]; other site 227882016960 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 227882016961 Nitrate and nitrite sensing; Region: NIT; pfam08376 227882016962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882016963 ATP binding site [chemical binding]; other site 227882016964 Mg2+ binding site [ion binding]; other site 227882016965 G-X-G motif; other site 227882016966 transcription termination factor Rho; Provisional; Region: PRK12678 227882016967 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 227882016968 Protein of unknown function (DUF742); Region: DUF742; pfam05331 227882016969 5-oxoprolinase; Region: PLN02666 227882016970 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 227882016971 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 227882016972 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 227882016973 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 227882016974 glycerol kinase; Provisional; Region: glpK; PRK00047 227882016975 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 227882016976 N- and C-terminal domain interface [polypeptide binding]; other site 227882016977 putative active site [active] 227882016978 putative MgATP binding site [chemical binding]; other site 227882016979 catalytic site [active] 227882016980 metal binding site [ion binding]; metal-binding site 227882016981 putative homotetramer interface [polypeptide binding]; other site 227882016982 putative glycerol binding site [chemical binding]; other site 227882016983 homodimer interface [polypeptide binding]; other site 227882016984 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cl00200 227882016985 amphipathic channel; other site 227882016986 Asn-Pro-Ala signature motifs; other site 227882016987 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 227882016988 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 227882016989 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 227882016990 metal binding site [ion binding]; metal-binding site 227882016991 active site 227882016992 I-site; other site 227882016993 lipid-transfer protein; Provisional; Region: PRK06059 227882016994 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal 3-ketacyl-; Region: SCP-x_thiolase; cd00829 227882016995 active site 227882016996 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 227882016997 DUF35 OB-fold domain; Region: DUF35; pfam01796 227882016998 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_16; cd04674 227882016999 nudix motif; other site 227882017000 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 227882017001 trimer interface [polypeptide binding]; other site 227882017002 active site 227882017003 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 227882017004 catalytic site [active] 227882017005 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 227882017006 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 227882017007 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 227882017008 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 227882017009 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882017010 DNA-binding site [nucleotide binding]; DNA binding site 227882017011 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 227882017012 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882017013 homodimer interface [polypeptide binding]; other site 227882017014 catalytic residue [active] 227882017015 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 227882017016 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 227882017017 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 227882017018 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 227882017019 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 227882017020 HPr interaction site; other site 227882017021 glycerol kinase (GK) interaction site [polypeptide binding]; other site 227882017022 active site 227882017023 phosphorylation site [posttranslational modification] 227882017024 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 227882017025 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 227882017026 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 227882017027 active site 227882017028 Substrate binding site [chemical binding]; other site 227882017029 Mg++ binding site [ion binding]; other site 227882017030 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 227882017031 putative trimer interface [polypeptide binding]; other site 227882017032 putative CoA binding site [chemical binding]; other site 227882017033 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 227882017034 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 227882017035 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 227882017036 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 227882017037 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 227882017038 Double zinc ribbon; Region: DZR; pfam12773 227882017039 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 227882017040 phosphopeptide binding site; other site 227882017041 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 227882017042 DNA binding residues [nucleotide binding] 227882017043 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 227882017044 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 227882017045 DNA binding residues [nucleotide binding] 227882017046 putative dimer interface [polypeptide binding]; other site 227882017047 DNA polymerase IV; Provisional; Region: PRK03348 227882017048 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 227882017049 active site 227882017050 DNA binding site [nucleotide binding] 227882017051 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 227882017052 glycine dehydrogenase; Provisional; Region: PRK05367 227882017053 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 227882017054 tetramer interface [polypeptide binding]; other site 227882017055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882017056 catalytic residue [active] 227882017057 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882017058 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 227882017059 catalytic residue [active] 227882017060 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 227882017061 VWA ywmD type:Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-...; Region: vWA_ywmD_type; cd01456 227882017062 metal ion-dependent adhesion site (MIDAS); other site 227882017063 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 227882017064 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 227882017065 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 227882017066 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882017067 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 227882017068 hydrophobic ligand binding site; other site 227882017069 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 227882017070 EamA-like transporter family; Region: EamA; cl01037 227882017071 EamA-like transporter family; Region: EamA; cl01037 227882017072 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 227882017073 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 227882017074 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882017075 DNA-binding site [nucleotide binding]; DNA binding site 227882017076 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 227882017077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882017078 homodimer interface [polypeptide binding]; other site 227882017079 catalytic residue [active] 227882017080 EamA-like transporter family; Region: EamA; cl01037 227882017081 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 227882017082 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882017083 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 227882017084 putative dimerization interface [polypeptide binding]; other site 227882017085 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 227882017086 Isochorismatase family; Region: Isochorismatase; pfam00857 227882017087 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 227882017088 catalytic triad [active] 227882017089 conserved cis-peptide bond; other site 227882017090 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 227882017091 iron-sulfur cluster [ion binding]; other site 227882017092 [2Fe-2S] cluster binding site [ion binding]; other site 227882017093 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 227882017094 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 227882017095 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882017096 NAD(P) binding site [chemical binding]; other site 227882017097 active site 227882017098 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 227882017099 classical (c) SDRs; Region: SDR_c; cd05233 227882017100 NAD(P) binding site [chemical binding]; other site 227882017101 active site 227882017102 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 227882017103 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 227882017104 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 227882017105 ligand binding site [chemical binding]; other site 227882017106 active site 227882017107 UGI interface [polypeptide binding]; other site 227882017108 catalytic site [active] 227882017109 DinB superfamily; Region: DinB_2; cl00986 227882017110 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 227882017111 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882017112 Apolipoprotein N-acyltransferase [Cell envelope biogenesis, outer membrane]; Region: Lnt; COG0815 227882017113 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 227882017114 putative active site [active] 227882017115 catalytic triad [active] 227882017116 putative dimer interface [polypeptide binding]; other site 227882017117 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 227882017118 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882017119 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 227882017120 Bacitracin resistance protein BacA; Region: BacA; cl00858 227882017121 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882017122 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 227882017123 Cupin domain; Region: Cupin_2; cl09118 227882017124 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882017125 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 227882017126 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 227882017127 dimer interface [polypeptide binding]; other site 227882017128 active site 227882017129 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 227882017130 elongation factor Tu; Reviewed; Region: PRK12736 227882017131 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 227882017132 G1 box; other site 227882017133 GEF interaction site [polypeptide binding]; other site 227882017134 GTP/Mg2+ binding site [chemical binding]; other site 227882017135 Switch I region; other site 227882017136 G2 box; other site 227882017137 G3 box; other site 227882017138 Switch II region; other site 227882017139 G4 box; other site 227882017140 G5 box; other site 227882017141 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 227882017142 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 227882017143 Antibiotic Binding Site [chemical binding]; other site 227882017144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 227882017145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882017146 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 227882017147 CoenzymeA binding site [chemical binding]; other site 227882017148 subunit interaction site [polypeptide binding]; other site 227882017149 PHB binding site; other site 227882017150 NlpC/P60 family; Region: NLPC_P60; cl11438 227882017151 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 227882017152 Sodium:solute symporter family; Region: SSF; cl00456 227882017153 Protein of unknown function, DUF485; Region: DUF485; cl01231 227882017154 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 227882017155 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 227882017156 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 227882017157 trimer interface [polypeptide binding]; other site 227882017158 putative metal binding site [ion binding]; other site 227882017159 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 227882017160 putative trimer interface [polypeptide binding]; other site 227882017161 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the 6-...; Region: LbH_MAT_like; cd04647 227882017162 trimer interface [polypeptide binding]; other site 227882017163 active site 227882017164 substrate binding site [chemical binding]; other site 227882017165 putative CoA binding site [chemical binding]; other site 227882017166 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 227882017167 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 227882017168 non-specific DNA binding site [nucleotide binding]; other site 227882017169 salt bridge; other site 227882017170 sequence-specific DNA binding site [nucleotide binding]; other site 227882017171 Cupin domain; Region: Cupin_2; cl09118 227882017172 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-...; Region: PA2301; cd04939 227882017173 putative deacylase active site [active] 227882017174 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 227882017175 Cation efflux family; Region: Cation_efflux; cl00316 227882017176 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882017177 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 227882017178 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 227882017179 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 227882017180 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882017181 DinB superfamily; Region: DinB_2; cl00986 227882017182 Cation efflux family; Region: Cation_efflux; cl00316 227882017183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882017184 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 227882017185 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 227882017186 catalytic core [active] 227882017187 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 227882017188 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 227882017189 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 227882017190 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 227882017191 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (...; Region: DEADc; cd00268 227882017192 ATP binding site [chemical binding]; other site 227882017193 Mg++ binding site [ion binding]; other site 227882017194 motif III; other site 227882017195 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 227882017196 nucleotide binding region [chemical binding]; other site 227882017197 ATP-binding site [chemical binding]; other site 227882017198 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 227882017199 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 227882017200 active site 227882017201 metal binding site [ion binding]; metal-binding site 227882017202 DNA binding site [nucleotide binding] 227882017203 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 227882017204 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882017205 Walker A/P-loop; other site 227882017206 ATP binding site [chemical binding]; other site 227882017207 Q-loop/lid; other site 227882017208 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882017209 ABC transporter signature motif; other site 227882017210 Walker B; other site 227882017211 D-loop; other site 227882017212 H-loop/switch region; other site 227882017213 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 227882017214 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882017215 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 227882017216 active site residue [active] 227882017217 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 227882017218 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 227882017219 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882017220 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 227882017221 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882017222 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 227882017223 catalytic residue [active] 227882017224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882017225 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 227882017226 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 227882017227 putative active site [active] 227882017228 putative metal binding site [ion binding]; other site 227882017229 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 227882017230 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 227882017231 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882017232 DNA-binding site [nucleotide binding]; DNA binding site 227882017233 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 227882017234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882017235 homodimer interface [polypeptide binding]; other site 227882017236 catalytic residue [active] 227882017237 EamA-like transporter family; Region: EamA; cl01037 227882017238 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882017239 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 227882017240 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882017241 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882017242 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 227882017243 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882017244 DNA-binding site [nucleotide binding]; DNA binding site 227882017245 UTRA domain; Region: UTRA; cl01230 227882017246 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 227882017247 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882017248 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882017249 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882017250 active site 227882017251 phosphorylation site [posttranslational modification] 227882017252 intermolecular recognition site; other site 227882017253 dimerization interface [polypeptide binding]; other site 227882017254 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882017255 DNA binding residues [nucleotide binding] 227882017256 dimerization interface [polypeptide binding]; other site 227882017257 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 227882017258 Histidine kinase; Region: HisKA_3; pfam07730 227882017259 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 227882017260 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882017261 Walker A/P-loop; other site 227882017262 ATP binding site [chemical binding]; other site 227882017263 Q-loop/lid; other site 227882017264 ABC transporter signature motif; other site 227882017265 Walker B; other site 227882017266 D-loop; other site 227882017267 H-loop/switch region; other site 227882017268 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 227882017269 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 227882017270 active site 227882017271 SUMO-1 interface [polypeptide binding]; other site 227882017272 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 227882017273 adenylosuccinate lyase; Region: purB; TIGR00928 227882017274 tetramer interface [polypeptide binding]; other site 227882017275 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 227882017276 active site 227882017277 catalytic triad [active] 227882017278 oxyanion hole [active] 227882017279 Domain of unknown function DUF21; Region: DUF21; pfam01595 227882017280 FOG: CBS domain [General function prediction only]; Region: COG0517 227882017281 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 227882017282 Domain of unknown function DUF21; Region: DUF21; pfam01595 227882017283 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 227882017284 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 227882017285 Transporter associated domain; Region: CorC_HlyC; cl08393 227882017286 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 227882017287 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 227882017288 Coenzyme A binding pocket [chemical binding]; other site 227882017289 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 227882017290 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882017291 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 227882017292 FtsX-like permease family; Region: FtsX; pfam02687 227882017293 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 227882017294 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 227882017295 Walker A/P-loop; other site 227882017296 ATP binding site [chemical binding]; other site 227882017297 Q-loop/lid; other site 227882017298 ABC transporter signature motif; other site 227882017299 Walker B; other site 227882017300 D-loop; other site 227882017301 H-loop/switch region; other site 227882017302 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882017303 S-adenosylmethionine binding site [chemical binding]; other site 227882017304 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; cl14892 227882017305 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882017306 DNA binding residues [nucleotide binding] 227882017307 dimerization interface [polypeptide binding]; other site 227882017308 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 227882017309 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 227882017310 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 227882017311 inhibitor-cofactor binding pocket; inhibition site 227882017312 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882017313 catalytic residue [active] 227882017314 biotin synthase; Validated; Region: PRK06256 227882017315 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 227882017316 FeS/SAM binding site; other site 227882017317 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 227882017318 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 227882017319 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882017320 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 227882017321 catalytic residue [active] 227882017322 Domain of unknown function (DUF397); Region: DUF397; pfam04149 227882017323 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 227882017324 non-specific DNA binding site [nucleotide binding]; other site 227882017325 salt bridge; other site 227882017326 sequence-specific DNA binding site [nucleotide binding]; other site 227882017327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882017328 NlpC/P60 family; Region: NLPC_P60; cl11438 227882017329 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 227882017330 oligomer interface [polypeptide binding]; other site 227882017331 active site residues [active] 227882017332 Phd_YefM; Region: PhdYeFM; cl09153 227882017333 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 227882017334 alpha-gamma subunit interface [polypeptide binding]; other site 227882017335 beta-gamma subunit interface [polypeptide binding]; other site 227882017336 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407 227882017337 gamma-beta subunit interface [polypeptide binding]; other site 227882017338 alpha-beta subunit interface [polypeptide binding]; other site 227882017339 urease subunit alpha; Reviewed; Region: ureC; PRK13206 227882017340 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 227882017341 subunit interactions [polypeptide binding]; other site 227882017342 active site 227882017343 flap region; other site 227882017344 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 227882017345 UreF; Region: UreF; pfam01730 227882017346 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 227882017347 UreD urease accessory protein; Region: UreD; cl00530 227882017348 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 227882017349 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882017350 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 227882017351 putative acyl-acceptor binding pocket; other site 227882017352 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 227882017353 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 227882017354 inhibitor-cofactor binding pocket; inhibition site 227882017355 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882017356 catalytic residue [active] 227882017357 Amidinotransferase; Region: Amidinotransf; cl12043 227882017358 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 227882017359 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882017360 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 227882017361 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882017362 active site 227882017363 phosphorylation site [posttranslational modification] 227882017364 intermolecular recognition site; other site 227882017365 dimerization interface [polypeptide binding]; other site 227882017366 LytTr DNA-binding domain; Region: LytTR; cl04498 227882017367 Sodium:solute symporter family; Region: SSF; cl00456 227882017368 Sodium:solute symporter family; Region: SSF; cl00456 227882017369 Sodium:solute symporter family; Region: SSF; cl00456 227882017370 Histidine kinase; Region: His_kinase; pfam06580 227882017371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 227882017372 ATP binding site [chemical binding]; other site 227882017373 Mg2+ binding site [ion binding]; other site 227882017374 G-X-G motif; other site 227882017375 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882017376 Catalytic domain of Protein Kinases; Region: PKc; cd00180 227882017377 active site 227882017378 ATP binding site [chemical binding]; other site 227882017379 substrate binding site [chemical binding]; other site 227882017380 activation loop (A-loop); other site 227882017381 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 227882017382 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 227882017383 6-phosphofructokinase; Provisional; Region: PRK03202 227882017384 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 227882017385 active site 227882017386 ADP/pyrophosphate binding site [chemical binding]; other site 227882017387 dimerization interface [polypeptide binding]; other site 227882017388 allosteric effector site; other site 227882017389 fructose-1,6-bisphosphate binding site; other site 227882017390 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 227882017391 catalytic triad [active] 227882017392 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 227882017393 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 227882017394 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 227882017395 active site 227882017396 catalytic residues [active] 227882017397 metal binding site [ion binding]; metal-binding site 227882017398 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882017399 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882017400 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 227882017401 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882017402 active site 227882017403 Cupin domain; Region: Cupin_2; cl09118 227882017404 Cytochrome P450; Region: p450; cl12078 227882017405 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 227882017406 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical...; Region: CHS_like; cd00831 227882017407 malonyl-CoA binding site [chemical binding]; other site 227882017408 dimer interface [polypeptide binding]; other site 227882017409 active site 227882017410 product binding site; other site 227882017411 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 227882017412 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 227882017413 NAD(P) binding site [chemical binding]; other site 227882017414 catalytic residues [active] 227882017415 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 227882017416 nudix motif; other site 227882017417 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 227882017418 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 227882017419 active site 227882017420 DNA binding site [nucleotide binding] 227882017421 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 227882017422 DNA binding site [nucleotide binding] 227882017423 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 227882017424 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 227882017425 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 227882017426 non-specific DNA binding site [nucleotide binding]; other site 227882017427 salt bridge; other site 227882017428 sequence-specific DNA binding site [nucleotide binding]; other site 227882017429 Cupin domain; Region: Cupin_2; cl09118 227882017430 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 227882017431 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 227882017432 NAD(P) binding site [chemical binding]; other site 227882017433 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 227882017434 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 227882017435 FAD binding site [chemical binding]; other site 227882017436 substrate binding site [chemical binding]; other site 227882017437 catalytic base [active] 227882017438 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 227882017439 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 227882017440 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 227882017441 active site 227882017442 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 227882017443 putative active site [active] 227882017444 catalytic site [active] 227882017445 Predicted periplasmic protein (DUF2233); Region: DUF2233; cl10481 227882017446 Protein of unknown function (DUF779); Region: DUF779; cl01432 227882017447 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 227882017448 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882017449 DNA-binding site [nucleotide binding]; DNA binding site 227882017450 UTRA domain; Region: UTRA; cl01230 227882017451 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 227882017452 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 227882017453 PYR/PP interface [polypeptide binding]; other site 227882017454 dimer interface [polypeptide binding]; other site 227882017455 TPP binding site [chemical binding]; other site 227882017456 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 227882017457 TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 227882017458 TPP-binding site; other site 227882017459 KduI/IolB family; Region: KduI; cl01508 227882017460 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 227882017461 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 227882017462 substrate binding site [chemical binding]; other site 227882017463 ATP binding site [chemical binding]; other site 227882017464 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 227882017465 putative ligand binding site [chemical binding]; other site 227882017466 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 227882017467 TM-ABC transporter signature motif; other site 227882017468 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 227882017469 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 227882017470 Walker A/P-loop; other site 227882017471 ATP binding site [chemical binding]; other site 227882017472 Q-loop/lid; other site 227882017473 ABC transporter signature motif; other site 227882017474 Walker B; other site 227882017475 D-loop; other site 227882017476 H-loop/switch region; other site 227882017477 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 227882017478 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 227882017479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882017480 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 227882017481 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882017482 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882017483 DNA binding site [nucleotide binding] 227882017484 domain linker motif; other site 227882017485 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 227882017486 dimerization interface [polypeptide binding]; other site 227882017487 ligand binding site [chemical binding]; other site 227882017488 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 227882017489 anti sigma factor interaction site; other site 227882017490 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882017491 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 227882017492 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 227882017493 tetramerization interface [polypeptide binding]; other site 227882017494 NAD(P) binding site [chemical binding]; other site 227882017495 catalytic residues [active] 227882017496 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 227882017497 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 227882017498 inhibitor-cofactor binding pocket; inhibition site 227882017499 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882017500 catalytic residue [active] 227882017501 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 227882017502 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 227882017503 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 227882017504 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 227882017505 dimer interface [polypeptide binding]; other site 227882017506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 227882017507 catalytic residue [active] 227882017508 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 227882017509 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882017510 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG...; Region: CAS_like; cl00184 227882017511 peptide synthase; Validated; Region: PRK05691 227882017512 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882017513 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 227882017514 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 227882017515 putative trimer interface [polypeptide binding]; other site 227882017516 putative CoA binding site [chemical binding]; other site 227882017517 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 227882017518 amidase catalytic site [active] 227882017519 Zn binding residues [ion binding]; other site 227882017520 substrate binding site [chemical binding]; other site 227882017521 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882017522 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882017523 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 227882017524 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 227882017525 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl14614 227882017526 NAD(P) binding site [chemical binding]; other site 227882017527 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 227882017528 putative active site [active] 227882017529 heme pocket [chemical binding]; other site 227882017530 PAS fold; Region: PAS_4; pfam08448 227882017531 GAF domain; Region: GAF; cl00853 227882017532 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882017533 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882017534 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 227882017535 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 227882017536 NAD(P) binding site [chemical binding]; other site 227882017537 catalytic residues [active] 227882017538 GAF domain; Region: GAF; cl00853 227882017539 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882017540 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 227882017541 amidase catalytic site [active] 227882017542 Zn binding residues [ion binding]; other site 227882017543 substrate binding site [chemical binding]; other site 227882017544 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882017545 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 227882017546 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882017547 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 227882017548 N- and C-terminal domain interface [polypeptide binding]; other site 227882017549 D-xylulose kinase; Region: XylB; TIGR01312 227882017550 active site 227882017551 MgATP binding site [chemical binding]; other site 227882017552 catalytic site [active] 227882017553 metal binding site [ion binding]; metal-binding site 227882017554 carbohydrate binding site [chemical binding]; other site 227882017555 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 227882017556 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 227882017557 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 227882017558 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882017559 active site 227882017560 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882017561 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 227882017562 putative NADP binding site [chemical binding]; other site 227882017563 active site 227882017564 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882017565 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 227882017566 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 227882017567 homodimer interface [polypeptide binding]; other site 227882017568 active site 227882017569 TDP-binding site; other site 227882017570 acceptor substrate-binding pocket; other site 227882017571 Cytochrome P450; Region: p450; cl12078 227882017572 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882017573 putative substrate translocation pore; other site 227882017574 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 227882017575 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 227882017576 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882017577 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 227882017578 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 227882017579 classical (c) SDRs; Region: SDR_c; cd05233 227882017580 NAD(P) binding site [chemical binding]; other site 227882017581 active site 227882017582 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 227882017583 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882017584 DNA binding site [nucleotide binding] 227882017585 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 227882017586 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 227882017587 putative ligand binding site [chemical binding]; other site 227882017588 exopolyphosphatase; Region: exo_poly_only; TIGR03706 227882017589 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 227882017590 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 227882017591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882017592 S-adenosylmethionine binding site [chemical binding]; other site 227882017593 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 227882017594 oxidoreductase; Provisional; Region: PRK06128 227882017595 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 227882017596 NAD binding site [chemical binding]; other site 227882017597 metal binding site [ion binding]; metal-binding site 227882017598 active site 227882017599 short chain dehydrogenase; Validated; Region: PRK05855 227882017600 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882017601 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882017602 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cl00200 227882017603 amphipathic channel; other site 227882017604 Asn-Pro-Ala signature motifs; other site 227882017605 glycerol kinase; Provisional; Region: glpK; PRK00047 227882017606 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 227882017607 N- and C-terminal domain interface [polypeptide binding]; other site 227882017608 putative active site [active] 227882017609 putative MgATP binding site [chemical binding]; other site 227882017610 catalytic site [active] 227882017611 metal binding site [ion binding]; metal-binding site 227882017612 putative homotetramer interface [polypeptide binding]; other site 227882017613 putative glycerol binding site [chemical binding]; other site 227882017614 homodimer interface [polypeptide binding]; other site 227882017615 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 227882017616 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 227882017617 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 227882017618 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 227882017619 catalytic residue [active] 227882017620 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 227882017621 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 227882017622 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 227882017623 dimer interface [polypeptide binding]; other site 227882017624 substrate binding site [chemical binding]; other site 227882017625 ATP binding site [chemical binding]; other site 227882017626 Sodium:solute symporter family; Region: SSF; cl00456 227882017627 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 227882017628 Jacalin-like lectin domains of putative endonucleases/exonucleases/phosphatases and related proteins; Region: Jacalin_EEP; cd09615 227882017629 putative sugar binding site [chemical binding]; other site 227882017630 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 227882017631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882017632 dimer interface [polypeptide binding]; other site 227882017633 conserved gate region; other site 227882017634 putative PBP binding loops; other site 227882017635 ABC-ATPase subunit interface; other site 227882017636 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 227882017637 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 227882017638 Walker A/P-loop; other site 227882017639 ATP binding site [chemical binding]; other site 227882017640 Q-loop/lid; other site 227882017641 ABC transporter signature motif; other site 227882017642 Walker B; other site 227882017643 D-loop; other site 227882017644 H-loop/switch region; other site 227882017645 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 227882017646 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 227882017647 substrate binding pocket [chemical binding]; other site 227882017648 membrane-bound complex binding site; other site 227882017649 hinge residues; other site 227882017650 Predicted acetyltransferase [General function prediction only]; Region: COG3393 227882017651 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 227882017652 Coenzyme A binding pocket [chemical binding]; other site 227882017653 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882017654 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 227882017655 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 227882017656 active site 227882017657 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 227882017658 non-prolyl cis peptide bond; other site 227882017659 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882017660 isocitrate dehydrogenase, NADP-dependent, monomeric type; Region: monomer_idh; TIGR00178 227882017661 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 227882017662 Mechanosensitive ion channel; Region: MS_channel; pfam00924 227882017663 enoyl-CoA hydratase; Provisional; Region: PRK08259 227882017664 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 227882017665 substrate binding site [chemical binding]; other site 227882017666 oxyanion hole (OAH) forming residues; other site 227882017667 trimer interface [polypeptide binding]; other site 227882017668 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 227882017669 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882017670 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 227882017671 Walker A/P-loop; other site 227882017672 ATP binding site [chemical binding]; other site 227882017673 Q-loop/lid; other site 227882017674 ABC transporter signature motif; other site 227882017675 Walker B; other site 227882017676 D-loop; other site 227882017677 H-loop/switch region; other site 227882017678 Transglycosylase; Region: Transgly; cl07896 227882017679 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 227882017680 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 227882017681 Putative amidase domain; Region: Amidase_6; pfam12671 227882017682 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 227882017683 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 227882017684 TIGR02680 family protein; Region: TIGR02680 227882017685 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 227882017686 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 227882017687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882017688 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 227882017689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882017690 NAD(P) binding site [chemical binding]; other site 227882017691 active site 227882017692 hypothetical membrane protein, TIGR01666; Region: YCCS 227882017693 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 227882017694 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 227882017695 NAD binding site [chemical binding]; other site 227882017696 catalytic Zn binding site [ion binding]; other site 227882017697 structural Zn binding site [ion binding]; other site 227882017698 pilin outer membrane usher protein SafC; Provisional; Region: PRK15223; cl14650 227882017699 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 227882017700 proposed catalytic triad [active] 227882017701 conserved cys residue [active] 227882017702 Domain of unknown function (DUF1931); Region: DUF1931; pfam09123 227882017703 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 227882017704 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 227882017705 active site 227882017706 catalytic tetrad [active] 227882017707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882017708 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882017709 aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339 227882017710 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 227882017711 putative dimerization interface [polypeptide binding]; other site 227882017712 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 227882017713 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 227882017714 StbA protein; Region: StbA; pfam06406 227882017715 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 227882017716 dimer interface [polypeptide binding]; other site 227882017717 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 227882017718 chaperone protein DnaJ; Provisional; Region: PRK14299 227882017719 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 227882017720 HSP70 interaction site [polypeptide binding]; other site 227882017721 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 227882017722 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 227882017723 DNA binding residues [nucleotide binding] 227882017724 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 227882017725 Clp amino terminal domain; Region: Clp_N; pfam02861 227882017726 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882017727 Walker A motif; other site 227882017728 ATP binding site [chemical binding]; other site 227882017729 Walker B motif; other site 227882017730 arginine finger; other site 227882017731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882017732 Walker A motif; other site 227882017733 ATP binding site [chemical binding]; other site 227882017734 Walker B motif; other site 227882017735 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 227882017736 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 227882017737 thioredoxin 2; Provisional; Region: PRK10996 227882017738 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 227882017739 catalytic residues [active] 227882017740 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 227882017741 ligand binding site [chemical binding]; other site 227882017742 flexible hinge region; other site 227882017743 putative oxidoreductase; Provisional; Region: PRK13984 227882017744 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 227882017745 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882017746 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882017747 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 227882017748 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 227882017749 tetramerization interface [polypeptide binding]; other site 227882017750 active site 227882017751 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882017752 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882017753 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 227882017754 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 227882017755 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases...; Region: lysozyme_like; cl00222 227882017756 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 227882017757 Peptidase family M23; Region: Peptidase_M23; pfam01551 227882017758 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 227882017759 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 227882017760 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 227882017761 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 227882017762 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 227882017763 ligand binding site [chemical binding]; other site 227882017764 oligomer interface [polypeptide binding]; other site 227882017765 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 227882017766 dimer interface [polypeptide binding]; other site 227882017767 N-terminal domain interface [polypeptide binding]; other site 227882017768 sulfate 1 binding site; other site 227882017769 alpha-1,2-mannosidase, putative; Region: aman2_put; TIGR01180 227882017770 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 227882017771 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 227882017772 Condensation domain; Region: Condensation; cl09290 227882017773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882017774 NAD(P) binding site [chemical binding]; other site 227882017775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882017776 active site 227882017777 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 227882017778 classical (c) SDRs; Region: SDR_c; cd05233 227882017779 NAD(P) binding site [chemical binding]; other site 227882017780 active site 227882017781 Family of unknown function (DUF706); Region: DUF706; pfam05153 227882017782 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 227882017783 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 227882017784 Coenzyme A binding pocket [chemical binding]; other site 227882017785 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 227882017786 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882017787 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 227882017788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882017789 dimer interface [polypeptide binding]; other site 227882017790 conserved gate region; other site 227882017791 putative PBP binding loops; other site 227882017792 ABC-ATPase subunit interface; other site 227882017793 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 227882017794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882017795 dimer interface [polypeptide binding]; other site 227882017796 conserved gate region; other site 227882017797 ABC-ATPase subunit interface; other site 227882017798 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 227882017799 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 227882017800 catalytic site [active] 227882017801 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882017802 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882017803 DNA binding site [nucleotide binding] 227882017804 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 227882017805 putative dimerization interface [polypeptide binding]; other site 227882017806 putative ligand binding site [chemical binding]; other site 227882017807 polygalacturonase ADPG; Region: PLN02218 227882017808 amidase; Provisional; Region: PRK12470 227882017809 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 227882017810 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 227882017811 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882017812 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882017813 DNA binding site [nucleotide binding] 227882017814 domain linker motif; other site 227882017815 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 227882017816 dimerization interface [polypeptide binding]; other site 227882017817 ligand binding site [chemical binding]; other site 227882017818 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 227882017819 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882017820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 227882017821 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 227882017822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 227882017823 dimer interface [polypeptide binding]; other site 227882017824 conserved gate region; other site 227882017825 putative PBP binding loops; other site 227882017826 ABC-ATPase subunit interface; other site 227882017827 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 227882017828 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 227882017829 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with the...; Region: GH85_ENGase; cd06547 227882017830 putative active site [active] 227882017831 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 227882017832 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 227882017833 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 227882017834 Transcriptional regulators [Transcription]; Region: FadR; COG2186 227882017835 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882017836 DNA-binding site [nucleotide binding]; DNA binding site 227882017837 FCD domain; Region: FCD; cl11656 227882017838 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 227882017839 ligand binding site [chemical binding]; other site 227882017840 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 227882017841 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 227882017842 Walker A/P-loop; other site 227882017843 ATP binding site [chemical binding]; other site 227882017844 Q-loop/lid; other site 227882017845 ABC transporter signature motif; other site 227882017846 Walker B; other site 227882017847 D-loop; other site 227882017848 H-loop/switch region; other site 227882017849 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 227882017850 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 227882017851 TM-ABC transporter signature motif; other site 227882017852 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 227882017853 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 227882017854 metal binding site [ion binding]; metal-binding site 227882017855 substrate binding pocket [chemical binding]; other site 227882017856 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 227882017857 classical (c) SDRs; Region: SDR_c; cd05233 227882017858 NAD(P) binding site [chemical binding]; other site 227882017859 active site 227882017860 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 227882017861 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 227882017862 active site 227882017863 catalytic tetrad [active] 227882017864 Domain of unknown function (DUF718); Region: DUF718; cl01281 227882017865 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 227882017866 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 227882017867 Protein of unknown function (DUF1222); Region: DUF1222; pfam06762 227882017868 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 227882017869 putative active site [active] 227882017870 heme pocket [chemical binding]; other site 227882017871 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 227882017872 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 227882017873 GAF domain; Region: GAF; cl00853 227882017874 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882017875 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882017876 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882017877 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 227882017878 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 227882017879 putative DNA binding site [nucleotide binding]; other site 227882017880 catalytic residue [active] 227882017881 putative H2TH interface [polypeptide binding]; other site 227882017882 putative catalytic residues [active] 227882017883 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 227882017884 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 227882017885 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 227882017886 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882017887 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882017888 DNA binding residues [nucleotide binding] 227882017889 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 227882017890 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 227882017891 putative active site [active] 227882017892 putative metal binding site [ion binding]; other site 227882017893 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 227882017894 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 227882017895 Ligand Binding Site [chemical binding]; other site 227882017896 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 227882017897 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 227882017898 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 227882017899 dimer interface [polypeptide binding]; other site 227882017900 putative anticodon binding site; other site 227882017901 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 227882017902 motif 1; other site 227882017903 dimer interface [polypeptide binding]; other site 227882017904 active site 227882017905 motif 2; other site 227882017906 motif 3; other site 227882017907 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 227882017908 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan...; Region: Sortase_E; cd05829 227882017909 active site 227882017910 putative catalytic site [active] 227882017911 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 227882017912 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 227882017913 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 227882017914 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 227882017915 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 227882017916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882017917 S-adenosylmethionine binding site [chemical binding]; other site 227882017918 PAS domain S-box; Region: sensory_box; TIGR00229 227882017919 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 227882017920 putative active site [active] 227882017921 heme pocket [chemical binding]; other site 227882017922 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 227882017923 metal binding site [ion binding]; metal-binding site 227882017924 active site 227882017925 I-site; other site 227882017926 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 227882017927 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 227882017928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882017929 NAD(P) binding site [chemical binding]; other site 227882017930 active site 227882017931 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882017932 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 227882017933 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 227882017934 dimerization interface [polypeptide binding]; other site 227882017935 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 227882017936 putative Iron-sulfur protein interface [polypeptide binding]; other site 227882017937 proximal heme binding site [chemical binding]; other site 227882017938 distal heme binding site [chemical binding]; other site 227882017939 putative dimer interface [polypeptide binding]; other site 227882017940 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 227882017941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882017942 domain; Region: Succ_DH_flav_C; pfam02910 227882017943 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 227882017944 4Fe-4S binding domain; Region: Fer4; cl02805 227882017945 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882017946 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 227882017947 putative acyl-acceptor binding pocket; other site 227882017948 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 227882017949 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 227882017950 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and...; Region: XynE_like; cd01830 227882017951 active site 227882017952 catalytic triad [active] 227882017953 oxyanion hole [active] 227882017954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 227882017955 S-adenosylmethionine binding site [chemical binding]; other site 227882017956 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 227882017957 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882017958 argininosuccinate lyase; Provisional; Region: PRK02186 227882017959 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 227882017960 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 227882017961 IucA / IucC family; Region: IucA_IucC; pfam04183 227882017962 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 227882017963 IucA / IucC family; Region: IucA_IucC; pfam04183 227882017964 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 227882017965 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 227882017966 dimer interface [polypeptide binding]; other site 227882017967 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 227882017968 active site 227882017969 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 227882017970 catalytic residues [active] 227882017971 substrate binding site [chemical binding]; other site 227882017972 PAS fold; Region: PAS_4; pfam08448 227882017973 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882017974 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 227882017975 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg5; cd04780 227882017976 DNA binding residues [nucleotide binding] 227882017977 putative dimer interface [polypeptide binding]; other site 227882017978 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 227882017979 Protein of unknown function (DUF1458); Region: DUF1458; cl01328 227882017980 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 227882017981 PAS fold; Region: PAS_4; pfam08448 227882017982 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 227882017983 putative active site [active] 227882017984 heme pocket [chemical binding]; other site 227882017985 GAF domain; Region: GAF; cl00853 227882017986 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882017987 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882017988 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 227882017989 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882017990 DNA binding residues [nucleotide binding] 227882017991 dimerization interface [polypeptide binding]; other site 227882017992 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 227882017993 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882017994 Uncharacterized conserved protein [Function unknown]; Region: HdeD; cl01277 227882017995 probable methyltransferase; Region: TIGR03438 227882017996 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 227882017997 TIGR03442 family protein; Region: TIGR03442 227882017998 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 227882017999 putative active site [active] 227882018000 putative dimer interface [polypeptide binding]; other site 227882018001 TIGR03440 family protein; Region: unchr_TIGR03440 227882018002 DinB superfamily; Region: DinB_2; cl00986 227882018003 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl00556 227882018004 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 227882018005 TIGR02452 family protein; Region: TIGR02452 227882018006 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 227882018007 PemK-like protein; Region: PemK; cl00995 227882018008 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins...; Region: Band_7_flotillin; cd03399 227882018009 amidase; Provisional; Region: PRK06061 227882018010 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 227882018011 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882018012 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882018013 DNA binding site [nucleotide binding] 227882018014 domain linker motif; other site 227882018015 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 227882018016 ligand binding site [chemical binding]; other site 227882018017 dimerization interface [polypeptide binding]; other site 227882018018 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 227882018019 catalytic residues [active] 227882018020 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 227882018021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882018022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882018023 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 227882018024 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 227882018025 active site 227882018026 catalytic residues [active] 227882018027 metal binding site [ion binding]; metal-binding site 227882018028 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 227882018029 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 227882018030 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882018031 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 227882018032 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882018033 Pirin-related protein [General function prediction only]; Region: COG1741 227882018034 Cupin domain; Region: Cupin_2; cl09118 227882018035 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 227882018036 Common central domain of tyrosinase; Region: Tyrosinase; pfam00264 227882018037 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 227882018038 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882018039 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 227882018040 Walker A/P-loop; other site 227882018041 ATP binding site [chemical binding]; other site 227882018042 Q-loop/lid; other site 227882018043 ABC transporter signature motif; other site 227882018044 Walker B; other site 227882018045 D-loop; other site 227882018046 H-loop/switch region; other site 227882018047 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 227882018048 glycosyltransferase, MGT family; Region: MGT; TIGR01426 227882018049 active site 227882018050 TDP-binding site; other site 227882018051 acceptor substrate-binding pocket; other site 227882018052 homodimer interface [polypeptide binding]; other site 227882018053 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882018054 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882018055 Phosphopantetheine attachment site; Region: PP-binding; cl09936 227882018056 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882018057 active site 227882018058 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882018059 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 227882018060 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 227882018061 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 227882018062 putative enoyl-(acyl-carrier-protein) reductase II; Region: enACPred_II; TIGR03151 227882018063 2-Nitropropane dioxygenase (NPD)-like domain, associated with polyketide synthases (PKS). NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and...; Region: NPD_PKS; cd04743 227882018064 FMN binding site [chemical binding]; other site 227882018065 substrate binding site [chemical binding]; other site 227882018066 putative catalytic residue [active] 227882018067 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 227882018068 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 227882018069 active site 227882018070 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 227882018071 Acyl transferase domain; Region: Acyl_transf_1; cl08282 227882018072 polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813 227882018073 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 227882018074 putative NADP binding site [chemical binding]; other site 227882018075 active site 227882018076 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 227882018077 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882018078 substrate binding pocket [chemical binding]; other site 227882018079 catalytic triad [active] 227882018080 HypX protein, N-terminal hydrolase domain; Region: FMT_core_HypX_N; cd08650 227882018081 putative active site [active] 227882018082 putative substrate binding site [chemical binding]; other site 227882018083 putative cosubstrate binding site; other site 227882018084 catalytic site [active] 227882018085 C-terminal subdomain of the Formyltransferase-like domain found in HypX-like proteins; Region: FMT_C_HypX; cd08701 227882018086 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 227882018087 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cd06558 227882018088 substrate binding site [chemical binding]; other site 227882018089 oxyanion hole (OAH) forming residues; other site 227882018090 trimer interface [polypeptide binding]; other site 227882018091 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 227882018092 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 227882018093 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 227882018094 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 227882018095 nickel binding site [ion binding]; other site 227882018096 Hydrogenase expression/synthesis hypA family; Region: HypA; cl00418 227882018097 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 227882018098 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 227882018099 Acylphosphatase; Region: Acylphosphatase; cl00551 227882018100 HypF finger; Region: zf-HYPF; pfam07503 227882018101 HypF finger; Region: zf-HYPF; pfam07503 227882018102 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 227882018103 HupF/HypC family; Region: HupF_HypC; cl00394 227882018104 Hydrogenase formation hypA family; Region: HypD; cl12072 227882018105 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 227882018106 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 227882018107 dimerization interface [polypeptide binding]; other site 227882018108 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 227882018109 ATP binding site [chemical binding]; other site 227882018110 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 227882018111 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 227882018112 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 227882018113 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 227882018114 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 227882018115 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 227882018116 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 227882018117 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 227882018118 putative metal binding site [ion binding]; other site 227882018119 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 227882018120 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 227882018121 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 227882018122 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 227882018123 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 227882018124 Histidine kinase; Region: HisKA_3; pfam07730 227882018125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882018126 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882018127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 227882018128 active site 227882018129 phosphorylation site [posttranslational modification] 227882018130 intermolecular recognition site; other site 227882018131 dimerization interface [polypeptide binding]; other site 227882018132 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882018133 dimerization interface [polypeptide binding]; other site 227882018134 DNA binding residues [nucleotide binding] 227882018135 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 227882018136 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 227882018137 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 227882018138 trehalose synthase; Region: treS_nterm; TIGR02456 227882018139 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 227882018140 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 227882018141 Phosphotransferase enzyme family; Region: APH; pfam01636 227882018142 glycogen branching enzyme; Provisional; Region: PRK05402 227882018143 E or 'early' set of sugar utilizing enzymes which may be related to the immunoglobulin and/or fibronectin type III superfamilies. These domains are associated with different types of catalytic domains at either the N-terminal or C-terminal end; Region: E_set; cl09101 227882018144 glycogen branching enzyme; Provisional; Region: PRK05402 227882018145 Glycogen branching enzyme N-terminus domain. Glycogen branching enzyme (AKA 1,4 alpha glucan branching enzyme) catalyzes the formation of alpha-1,6 branch points in either glycogen or starch by cleavage of the alpha-1,4 glucosidic linkage yielding a...; Region: Glycogen_branching_enzyme_N_term; cd02855 227882018146 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 227882018147 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 227882018148 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 227882018149 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882018150 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 227882018151 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 227882018152 DNA binding residues [nucleotide binding] 227882018153 ANTAR domain; Region: ANTAR; cl04297 227882018154 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 227882018155 hydrophobic ligand binding site; other site 227882018156 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 227882018157 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 227882018158 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 227882018159 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 227882018160 Walker A/P-loop; other site 227882018161 ATP binding site [chemical binding]; other site 227882018162 Q-loop/lid; other site 227882018163 ABC transporter signature motif; other site 227882018164 Walker B; other site 227882018165 D-loop; other site 227882018166 H-loop/switch region; other site 227882018167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 227882018168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 227882018169 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 227882018170 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 227882018171 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 227882018172 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family...; Region: ABC_OpuCA_Osmoprotection; cd03295 227882018173 Walker A/P-loop; other site 227882018174 ATP binding site [chemical binding]; other site 227882018175 Q-loop/lid; other site 227882018176 ABC transporter signature motif; other site 227882018177 Walker B; other site 227882018178 D-loop; other site 227882018179 H-loop/switch region; other site 227882018180 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 227882018181 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 227882018182 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 227882018183 Uncharacterised ACR, YkgG family COG1556; Region: DUF162; cl00674 227882018184 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 227882018185 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 227882018186 Cysteine-rich domain; Region: CCG; pfam02754 227882018187 Cysteine-rich domain; Region: CCG; pfam02754 227882018188 L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 227882018189 N- and C-terminal domain interface [polypeptide binding]; other site 227882018190 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 227882018191 active site 227882018192 catalytic site [active] 227882018193 metal binding site [ion binding]; metal-binding site 227882018194 ATP binding site [chemical binding]; other site 227882018195 carbohydrate binding site [chemical binding]; other site 227882018196 short chain dehydrogenase; Validated; Region: PRK08324 227882018197 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 227882018198 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 227882018199 putative NAD(P) binding site [chemical binding]; other site 227882018200 active site 227882018201 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 227882018202 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 227882018203 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 227882018204 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 227882018205 Walker A/P-loop; other site 227882018206 ATP binding site [chemical binding]; other site 227882018207 Q-loop/lid; other site 227882018208 ABC transporter signature motif; other site 227882018209 Walker B; other site 227882018210 D-loop; other site 227882018211 H-loop/switch region; other site 227882018212 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 227882018213 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 227882018214 TM-ABC transporter signature motif; other site 227882018215 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 227882018216 TM-ABC transporter signature motif; other site 227882018217 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 227882018218 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 227882018219 ligand binding site [chemical binding]; other site 227882018220 Domain of unknown function (DUF718); Region: DUF718; cl01281 227882018221 Transcriptional regulators [Transcription]; Region: PurR; COG1609 227882018222 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 227882018223 DNA binding site [nucleotide binding] 227882018224 domain linker motif; other site 227882018225 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 227882018226 ligand binding site [chemical binding]; other site 227882018227 dimerization interface [polypeptide binding]; other site 227882018228 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 227882018229 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 227882018230 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 227882018231 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882018232 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 227882018233 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 227882018234 Cytochrome P450; Region: p450; cl12078 227882018235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882018236 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 227882018237 Predicted membrane protein [Function unknown]; Region: COG4129 227882018238 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 227882018239 Erythromycin esterase; Region: Erythro_esteras; pfam05139 227882018240 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 227882018241 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 227882018242 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882018243 oxidoreductase; Provisional; Region: PRK06196 227882018244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882018245 NAD(P) binding site [chemical binding]; other site 227882018246 active site 227882018247 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 227882018248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 227882018249 hypothetical protein; Provisional; Region: PRK07945 227882018250 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 227882018251 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 227882018252 active site 227882018253 catalytic residues [active] 227882018254 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 227882018255 putative sugar binding sites [chemical binding]; other site 227882018256 Q-X-W motif; other site 227882018257 VanZ like family; Region: VanZ; cl01971 227882018258 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 227882018259 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 227882018260 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 227882018261 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 227882018262 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 227882018263 G2 box; other site 227882018264 Switch I region; other site 227882018265 G3 box; other site 227882018266 Switch II region; other site 227882018267 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 227882018268 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 227882018269 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 227882018270 anti sigma factor interaction site; other site 227882018271 regulatory phosphorylation site [posttranslational modification]; other site 227882018272 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 227882018273 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 227882018274 putative NAD(P) binding site [chemical binding]; other site 227882018275 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 227882018276 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 227882018277 conserved cys residue [active] 227882018278 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 227882018279 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882018280 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 227882018281 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 227882018282 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 227882018283 active site 227882018284 metal binding site [ion binding]; metal-binding site 227882018285 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 227882018286 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 227882018287 putative dimer interface [polypeptide binding]; other site 227882018288 N-terminal domain interface [polypeptide binding]; other site 227882018289 putative substrate binding pocket (H-site) [chemical binding]; other site 227882018290 Cation efflux family; Region: Cation_efflux; cl00316 227882018291 Domain of unknown function (DUF385); Region: DUF385; cl04387 227882018292 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 227882018293 active site 227882018294 catalytic triad [active] 227882018295 Cytochrome P450; Region: p450; cl12078 227882018296 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 227882018297 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 227882018298 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 227882018299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882018300 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 227882018301 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 227882018302 Flavoprotein; Region: Flavoprotein; cl08021 227882018303 TM1410 hypothetical-related protein; Region: DUF297; cl00997 227882018304 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 227882018305 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 227882018306 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 227882018307 putative sugar binding sites [chemical binding]; other site 227882018308 Q-X-W motif; other site 227882018309 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 227882018310 transmembrane helices; other site 227882018311 PAS domain S-box; Region: sensory_box; TIGR00229 227882018312 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 227882018313 PAS fold; Region: PAS_4; pfam08448 227882018314 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 227882018315 GAF domain; Region: GAF; cl00853 227882018316 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882018317 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882018318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882018319 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 227882018320 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 227882018321 domain; Region: Glyco_hydro_2; pfam00703 227882018322 Bacterial Ig-like domain (group 1); Region: Big_1; cl10510 227882018323 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 227882018324 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cd00161 227882018325 putative sugar binding sites [chemical binding]; other site 227882018326 Q-X-W motif; other site 227882018327 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 227882018328 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 227882018329 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 227882018330 putative active site [active] 227882018331 putative substrate binding site [chemical binding]; other site 227882018332 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 227882018333 putative FMN binding site [chemical binding]; other site 227882018334 putative catalytic residues [active] 227882018335 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 227882018336 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 227882018337 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 227882018338 Subtilisin inhibitor-like; Region: SSI; cl11594 227882018339 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 227882018340 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 227882018341 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882018342 Major Facilitator Superfamily; Region: MFS_1; pfam07690 227882018343 putative substrate translocation pore; other site 227882018344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 227882018345 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 227882018346 putative hydrophobic ligand binding site [chemical binding]; other site 227882018347 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 227882018348 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 227882018349 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882018350 Walker A/P-loop; other site 227882018351 ATP binding site [chemical binding]; other site 227882018352 Q-loop/lid; other site 227882018353 ABC transporter signature motif; other site 227882018354 Walker B; other site 227882018355 D-loop; other site 227882018356 H-loop/switch region; other site 227882018357 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 227882018358 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39D; cd02420 227882018359 putative active site [active] 227882018360 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 227882018361 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882018362 Walker A/P-loop; other site 227882018363 ATP binding site [chemical binding]; other site 227882018364 Q-loop/lid; other site 227882018365 ABC transporter signature motif; other site 227882018366 Walker B; other site 227882018367 D-loop; other site 227882018368 H-loop/switch region; other site 227882018369 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 227882018370 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 227882018371 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 227882018372 PHB binding site; other site 227882018373 CoenzymeA binding site [chemical binding]; other site 227882018374 subunit interaction site [polypeptide binding]; other site 227882018375 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 227882018376 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 227882018377 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 227882018378 GAF domain; Region: GAF; cl00853 227882018379 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 227882018380 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882018381 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 227882018382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cl09944 227882018383 active site 227882018384 phosphorylation site [posttranslational modification] 227882018385 intermolecular recognition site; other site 227882018386 dimerization interface [polypeptide binding]; other site 227882018387 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 227882018388 DNA binding residues [nucleotide binding] 227882018389 dimerization interface [polypeptide binding]; other site 227882018390 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 227882018391 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228 227882018392 Walker A/P-loop; other site 227882018393 ATP binding site [chemical binding]; other site 227882018394 Q-loop/lid; other site 227882018395 ABC transporter signature motif; other site 227882018396 Walker B; other site 227882018397 D-loop; other site 227882018398 H-loop/switch region; other site 227882018399 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 227882018400 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882018401 Walker A/P-loop; other site 227882018402 ATP binding site [chemical binding]; other site 227882018403 Q-loop/lid; other site 227882018404 ABC transporter signature motif; other site 227882018405 Walker B; other site 227882018406 D-loop; other site 227882018407 H-loop/switch region; other site 227882018408 Protein kinase domain; Region: Pkinase; pfam00069 227882018409 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882018410 active site 227882018411 ATP binding site [chemical binding]; other site 227882018412 substrate binding site [chemical binding]; other site 227882018413 activation loop (A-loop); other site 227882018414 Lanthionine synthetase C-like domain associated with serine threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown; Region: LanC_SerThrkinase; cd04791 227882018415 active site 227882018416 zinc binding site [ion binding]; other site 227882018417 PAS fold; Region: PAS_3; pfam08447 227882018418 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 227882018419 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 227882018420 active site 227882018421 metal binding site [ion binding]; metal-binding site 227882018422 homotetramer interface [polypeptide binding]; other site 227882018423 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 227882018424 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 227882018425 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 227882018426 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 227882018427 Tet(M)-like subfamily. Tet(M), Tet(O), Tet(W), and OtrA are tetracycline resistance genes found in Gram-positive and Gram-negative bacteria. Tetracyclines inhibit protein synthesis by preventing aminoacyl-tRNA from binding to the ribosomal acceptor...; Region: TetM_like; cd04168 227882018428 G1 box; other site 227882018429 putative GEF interaction site [polypeptide binding]; other site 227882018430 GTP/Mg2+ binding site [chemical binding]; other site 227882018431 Switch I region; other site 227882018432 G2 box; other site 227882018433 G3 box; other site 227882018434 Switch II region; other site 227882018435 G4 box; other site 227882018436 G5 box; other site 227882018437 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 227882018438 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines...; Region: Tet_like_IV; cd01684 227882018439 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a GTP-...; Region: Tet_C; cd03711 227882018440 Uncharacterized conserved protein [Function unknown]; Region: COG3391 227882018441 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 227882018442 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 227882018443 Transposase; Region: DEDD_Tnp_IS110; pfam01548 227882018444 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 227882018445 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 227882018446 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 227882018447 metal binding site [ion binding]; metal-binding site 227882018448 active site 227882018449 I-site; other site 227882018450 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 227882018451 AAA-like domain; Region: AAA_10; pfam12846 227882018452 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 227882018453 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 227882018454 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 227882018455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 227882018456 non-specific DNA binding site [nucleotide binding]; other site 227882018457 salt bridge; other site 227882018458 sequence-specific DNA binding site [nucleotide binding]; other site 227882018459 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882018460 Predicted kinase [General function prediction only]; Region: COG0645 227882018461 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882018462 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 227882018463 Domain of unknown function (DUF1932); Region: DUF1932; pfam09130 227882018464 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 227882018465 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 227882018466 motif II; other site 227882018467 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 227882018468 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 227882018469 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 227882018470 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 227882018471 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 227882018472 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 227882018473 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 227882018474 helicase Cas3; Provisional; Region: PRK09694 227882018475 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 227882018476 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882018477 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 227882018478 Transposase; Region: DDE_Tnp_ISL3; pfam01610 227882018479 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 227882018480 transposase; Provisional; Region: PRK06526 227882018481 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 227882018482 Walker A motif; other site 227882018483 ATP binding site [chemical binding]; other site 227882018484 Walker B motif; other site 227882018485 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 227882018486 Integrase core domain; Region: rve; cl01316 227882018487 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 227882018488 Transposase; Region: DDE_Tnp_ISL3; pfam01610 227882018489 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 227882018490 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 227882018491 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 227882018492 SMI1 / KNR4 family; Region: SMI1_KNR4; cl01747 227882018493 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 227882018494 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 227882018495 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 227882018496 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 227882018497 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly...; Region: RICIN; cl00126 227882018498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 227882018499 non-specific DNA binding site [nucleotide binding]; other site 227882018500 salt bridge; other site 227882018501 sequence-specific DNA binding site [nucleotide binding]; other site 227882018502 Integrase core domain; Region: rve; cl01316 227882018503 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 227882018504 Predicted helicase [General function prediction only]; Region: COG4889 227882018505 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 227882018506 ATP binding site [chemical binding]; other site 227882018507 putative Mg++ binding site [ion binding]; other site 227882018508 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882018509 Helicase associated domain; Region: HA; pfam03457 227882018510 Helicase associated domain; Region: HA; pfam03457 227882018511 Helicase associated domain; Region: HA; pfam03457 227882018512 response regulator FixJ; Provisional; Region: fixJ; PRK09390 227882018513 Recombination endonuclease VII; Region: Endonuclease_7; pfam02945 227882018514 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 227882018515 active site 227882018516 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 227882018517 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 227882018518 ATP binding site [chemical binding]; other site 227882018519 putative Mg++ binding site [ion binding]; other site 227882018520 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 227882018521 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 227882018522 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 227882018523 non-specific DNA binding site [nucleotide binding]; other site 227882018524 salt bridge; other site 227882018525 sequence-specific DNA binding site [nucleotide binding]; other site 227882018526 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882018527 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882018528 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 227882018529 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 227882018530 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 227882018531 active site 227882018532 ATP binding site [chemical binding]; other site 227882018533 substrate binding site [chemical binding]; other site 227882018534 activation loop (A-loop); other site 227882018535 chaperone protein DnaJ; Provisional; Region: PRK14295 227882018536 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 227882018537 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 227882018538 Protein of unknown function (DUF721); Region: DUF721; cl02324 227882018539 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 227882018540 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882018541 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 227882018542 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 227882018543 DNA-binding site [nucleotide binding]; DNA binding site 227882018544 UTRA domain; Region: UTRA; cl01230 227882018545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 227882018546 Transcription factor WhiB; Region: Whib; pfam02467 227882018547 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 227882018548 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 227882018549 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 227882018550 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882018551 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation...; Region: ASCH; cl01020 227882018552 Lsr2; Region: Lsr2; pfam11774 227882018553 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 227882018554 Coenzyme A binding pocket [chemical binding]; other site 227882018555 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 227882018556 Transposase; Region: DEDD_Tnp_IS110; pfam01548 227882018557 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 227882018558 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882018559 ParB-like nuclease domain; Region: ParBc; cl02129 227882018560 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 227882018561 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 227882018562 P loop; other site 227882018563 Nucleotide binding site [chemical binding]; other site 227882018564 DTAP/Switch II; other site 227882018565 Switch I; other site 227882018566 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 227882018567 Magnesium ion binding site [ion binding]; other site 227882018568 TrwC relaxase; Region: TrwC; cl08490 227882018569 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 227882018570 RNA polymerase factor sigma-54; Provisional; Region: PRK12469 227882018571 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 227882018572 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 227882018573 DNA binding residues [nucleotide binding] 227882018574 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 227882018575 active site 227882018576 DNA binding site [nucleotide binding] 227882018577 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 227882018578 DNA binding site [nucleotide binding] 227882018579 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 227882018580 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 227882018581 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 227882018582 ATP binding site [chemical binding]; other site 227882018583 putative Mg++ binding site [ion binding]; other site 227882018584 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 227882018585 Helicase associated domain; Region: HA; pfam03457 227882018586 Helicase associated domain; Region: HA; pfam03457 227882018587 Helicase associated domain; Region: HA; pfam03457 227882018588 Helicase associated domain; Region: HA; pfam03457